Sample records for argus halon suppression

  1. Memorandum, Managed Phase Out of Halon Fixed Fire Suppression Systems- May 5, 1993

    Broader source: Energy.gov [DOE]

    The purpose of this memorandum is to provide additional interim departmental criteria on the management of the reduction and potential elimination of Halon fire extinguishing systems within the Department of Energy (DOE). This memorandum supplements the joint Office of Safety and Quality Assurance/Office of Projects and Facilities Management memorandum of September 27, 1990, in which guidance was provided on the installation of new Halon 1301 fixed fire suppression systems and halon 1211 portable fire extinguishers.

  2. Memorandum, Managed Phase Out of Halon Fixed Fire Suppression...

    Broader source: Energy.gov (indexed) [DOE]

    the management of the reduction and potential elimination of Halon fire extinguishing systems within the Department of Energy (DOE). This memorandum supplements the joint Office...

  3. Health effects of Halon 1301 exposure

    SciTech Connect (OSTI)

    Holness, D.L.; House, R.A. (Department of Occupational and Environmental Health, St Michael's Hospital, University of Toronto (Canada))

    1992-07-01T23:59:59.000Z

    An accidental discharge of a Halon 1301 system is reported. Thirty-one workers were assessed, 22 who were present at the time of the discharge, and 9 who worked the next shift. The incident was complicated by a small Freon-22 leak several hours later. Throat, eye, and nasal irritation and lightheadedness were reported by the majority of workers. Workers present during the halon discharge reported significantly more lightheadedness, headache, voice change, cough, and a fast heartbeat than did those who worked the later shift. These differences were significant even after correcting for confounding factors such as age, sex, and sense of anxiety at the time of the incident. The possible causes for the irritant symptoms include breakdown products of Halon 1301 and Freon-22 or contaminants from the halon discharge system. Although these irritant effects may not be an effect of Halon 1301 alone, they may occur in these discharge situations, and workers should be advised of this possibility. The possible cardiac and central nervous system effects also should be considered. The importance of a clear-cut protocol to deal with such incidents as well as worker education are discussed.

  4. Requirements And Instructions For Shipping Halon To The Defense Logistics Agency (DLA) Halon Repository

    Broader source: Energy.gov [DOE]

    Disposition of excess Halon 1301 is now done in accordance with Executive Order 13148 — “Greening the Government Through Leadership in Environmental Management ”, Section 505 (c). An SF-122 form (or equivalent documentation) should be approved by the DLA prior to shipment.

  5. argus gamma camera: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Experiments show that Argus-1 detects transient Sorin, Daniel J. 40 ARGUS: Rete + DBMS Efficient Persistent Profile Matching on Large-Volume Data Streams Materials Science...

  6. argus detector messung: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Experiments show that Argus-1 detects transient Sorin, Daniel J. 22 ARGUS: Rete + DBMS Efficient Persistent Profile Matching on Large-Volume Data Streams Materials Science...

  7. Benefits of ARG-US "Smart Drum"

    E-Print Network [OSTI]

    Kemner, Ken

    Program Manager Savannah River National Laboratory paul.blanton@srnl.doe.gov 803.725.3738 ARG-US RFIDBenefits of ARG-US "Smart Drum" Technology Argonne National Laboratory is a U.S. Department Nuclear Engineer, Section Manager Argonne National Laboratory yyliu@anl.gov 630.252.5127 Paul Blanton

  8. Feasibility and design of blast mitigation systems for naval applications using water mist fire suppression systems

    E-Print Network [OSTI]

    Kitchenka, Julie A

    2004-01-01T23:59:59.000Z

    The recent trend of using fine water mist systems to replace the legacy HALON- 1301 fire suppression systems warrants further study into other applications of the water mist systems. Preliminary research and investigation ...

  9. Argus Power Technology | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to:Ezfeedflag JumpID-fTriWildcatAntrim County,DelhiArdmore, Pennsylvania:Argent EnergyArgus Power

  10. argus event: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    data dynamics, and presents new challenges that are not addressed by traditional DBMS technologies Carbonell, Jaime 24 In GPS World, April 2000, pp. 20-30. Eyes of Argus...

  11. argus reactor: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    data dynamics, and presents new challenges that are not addressed by traditional DBMS technologies Carbonell, Jaime 22 In GPS World, April 2000, pp. 20-30. Eyes of Argus...

  12. Argus Energy WV, LLC wins 2007 Wetlands West Virginia Award

    SciTech Connect (OSTI)

    NONE

    2007-07-15T23:59:59.000Z

    Argus Energy's Kiah Creek Operation has received the 2007 Wetlands West Virginia Award presented by the West Virginian Coal Association. The operation was originally a 1267 acre underground mine in the Coalburg seam. Underground mining commenced in 2000 until the end of 2003 with more than two million tons of coal being produced. The creation of the wetlands was achieved during the operations. 8 photos.

  13. The Caribbean spiny lobster, Panuli-rus argus, is distributed from Brazil

    E-Print Network [OSTI]

    870 The Caribbean spiny lobster, Panuli- rus argus, is distributed from Brazil throughout major commercial fisheries in Florida, the Caribbean and Brazil. Commercially, P. argus is especially seen within a spe- cies. Because previous studies did not include populations from Brazil, Sarver et al

  14. The Argus Eye: A New Tool for Robotics Patrick Baker, Abhijit S. Ogale and Cornelia Fermuller

    E-Print Network [OSTI]

    Fermüller, Cornelia

    The Argus Eye: A New Tool for Robotics Patrick Baker, Abhijit S. Ogale and Cornelia Ferm Introduction: Eyes, Control and 3D Motion What an amazing display it is to watch a bird of prey circling throughout the animal kingdom. Michael Land provides a land- scape of eye evolution in [2]. Considering

  15. A New Argus Direct Conversion Receiver and Digital Array Receiver/Processor

    E-Print Network [OSTI]

    Ellingson, Steven W.

    A New Argus Direct Conversion Receiver and Digital Array Receiver/Processor Grant Hampson and Steve . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 References 20 Appendix A: Direct Conversion FPGA Source Code 21 Appendix B: Digital Receiver system. The new architecture consists of four main components: a Direct Conversion Receiver (DCR

  16. Food consumption and digestion time estimation of spotted scat, Scatophagus argus, using X-radiography technique

    SciTech Connect (OSTI)

    Hashim, Marina; Abidin, Diana Atiqah Zainal [School of Environmental and Natural Resource Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor (Malaysia); Das, Simon K. [Marine Ecosystem Research Centre, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi (Malaysia); Ghaffar, Mazlan Abd. [School of Environmental and Natural Resource Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia and Marine Ecosystem Research Centre, Faculty of Science and Technology, Universiti Kebangsaan M (Malaysia)

    2014-09-03T23:59:59.000Z

    The present study was conducted to investigate the food consumption pattern and gastric emptying time using x-radiography technique in scats fish, Scatophagus argus feeding to satiation in laboratory conditions. Prior to feeding experiment, fish of various sizes were examined their stomach volume, using freshly prepared stomachs ligatured at the tips of the burret, where the maximum amount of distilled water collected in the stomach were measured (ml). Stomach volume is correlated with maximum food intake (S{sub max}) and it can estimate the maximum stomach distension by allometric model i.e volume=0.0000089W{sup 2.93}. Gastric emptying time was estimated using a qualitative X-radiography technique, where the fish of various sizes were fed to satiation at different time since feeding. All the experimental fish was feed into satiation using radio-opaque barium sulphate (BaSO{sub 4}) paste injected in the wet shrimp in proportion to the body weight. The BaSO{sub 4} was found suitable to track the movement of feed/prey in the stomach over time and gastric emptying time of scats fish can be estimated. The results of qualitative X-Radiography observation of gastric motility, showed the fish (200 gm) that fed to maximum satiation meal (circa 11 gm) completely emptied their stomach within 30 - 36 hrs. The results of the present study will provide the first baseline information on the stomach volume, gastric emptying of scats fish in captivity.

  17. Report on a 2009 mini-demonstration of the ARG-US Radio Frequency Identification (RFID) system in transportation.

    SciTech Connect (OSTI)

    Tsai, H.; Chen, K.; Jusko, M.; Craig, B.; Liu, Y.; Decision and Information Sciences

    2009-11-23T23:59:59.000Z

    The Packaging Certification Program (PCP) of the U.S. Department of Energy (DOE) Environmental Management (EM), Office of Packaging and Transportation (EM-14), has developed a radio frequency identification (RFID) tracking and monitoring system for the management of nuclear materials during storage and transportation. The system, developed by the PCP team at Argonne National Laboratory, consists of hardware (Mk-series sensor tags, fixed and handheld readers, form factor for multiple drum types, seal integrity sensors, and enhanced battery management), software (application programming interface, ARG-US software for local and remote/web applications, secure server and database management), and cellular/satellite communication interfaces for vehicle tracking and item monitoring during transport. The ability of the above system to provide accurate, real-time tracking and monitoring of the status of multiple, certified containers of nuclear materials has been successfully demonstrated in a week-long, 1,700-mile DEMO performed in April 2008. While the feedback from the approximately fifty (50) stakeholders who participated in and/or observed the DEMO progression were very positive and encouraging, two major areas of further improvements - system integration and web application enhancement - were identified in the post-DEMO evaluation. The principal purpose of the MiniDemo described in this report was to verify these two specific improvements. The MiniDemo was conducted on August 28, 2009. In terms of system integration, a hybrid communication interface - combining the RFID item-monitoring features and a commercial vehicle tracking system by Qualcomm - was developed and implemented. In the MiniDemo, the new integrated system worked well in reporting tag status and vehicle location accurately and promptly. There was no incompatibility of components. The robust commercial communication gear, as expected, helped improve system reliability. The MiniDemo confirmed that system integration is technically feasible and reliable with the existing RFID and Qualcomm satellite equipment. In terms of web application, improvements in mapping, tracking, data presentation, and post-incident spatial query reporting were implemented in ARG-US, the application software that manages the dataflow among the RFID tags, readers, and servers. These features were tested in the MiniDemo and found to be satisfactory. The resulting web application is both informative and user-friendly. A joint developmental project is being planned between the PCP and the DOE TRANSCOM that uses the Qualcomm gear in vehicles for tracking and communication of radioactive material shipments across the country. Adding an RFID interface to TRANSCOM is a significant enhancement to the DOE infrastructure for tracking and monitoring shipments of radioactive materials.

  18. Explosion suppression system

    DOE Patents [OSTI]

    Sapko, Michael J. (Finleyville, PA); Cortese, Robert A. (Pittsburgh, PA)

    1992-01-01T23:59:59.000Z

    An explosion suppression system and triggering apparatus therefor are provided for quenching gas and dust explosions. An electrically actuated suppression mechanism which dispenses an extinguishing agent into the path ahead of the propagating flame is actuated by a triggering device which is light powered. This triggering device is located upstream of the propagating flame and converts light from the flame to an electrical actuation signal. A pressure arming device electrically connects the triggering device to the suppression device only when the explosion is sensed by a further characteristic thereof beside the flame such as the pioneer pressure wave. The light powered triggering device includes a solar panel which is disposed in the path of the explosion and oriented between horizontally downward and vertical. Testing mechanisms are also preferably provided to test the operation of the solar panel and detonator as well as the pressure arming mechanism.

  19. Optical Shelving: Suppressed Fluorescence

    E-Print Network [OSTI]

    Mould, R A

    2007-01-01T23:59:59.000Z

    The shelving phenomenon of quantum optics, originally observed by Dehmelt, is analyzed in terms of the nRules that are given in another paper. The heuristic value of these rules is apparent because they reveal the mechanism that enforces the suppression of fluorescence during the dark period associated with shelving.

  20. Optical Shelving: Suppressed Fluorescence

    E-Print Network [OSTI]

    Richard A Mould

    2011-04-11T23:59:59.000Z

    The shelving phenomenon of quantum optics, originally observed by Dehmelt, is analyzed in terms of the qRules that are given in another paper. The heuristic value of these rules is apparent because they not only describe the dark period during shelving, but they reveal the mechanism that enforces the suppression of fluorescence during that time.

  1. Pressure suppression containment system

    DOE Patents [OSTI]

    Gluntz, D.M.; Townsend, H.E.

    1994-03-15T23:59:59.000Z

    A pressure suppression containment system includes a containment vessel surrounding a reactor pressure vessel and defining a drywell therein containing a non-condensable gas. An enclosed wetwell pool is disposed inside the containment vessel, and a gravity driven cooling system (GDCS) pool is disposed above the wetwell pool in the containment vessel. The wetwell pool includes a plenum for receiving the non-condensable gas carried with steam from the drywell following a loss-of-coolant-accident (LOCA). The wetwell plenum is vented to a plenum above the GDCS pool following the LOCA for suppressing pressure rise within the containment vessel. A method of operation includes channeling steam released into the drywell following the LOCA into the wetwell pool for cooling along with the non-condensable gas carried therewith. The GDCS pool is then drained by gravity, and the wetwell plenum is vented into the GDCS plenum for channeling the non-condensable gas thereto. 6 figures.

  2. Pressure suppression containment system

    DOE Patents [OSTI]

    Gluntz, Douglas M. (San Jose, CA); Townsend, Harold E. (San Jose, CA)

    1994-03-15T23:59:59.000Z

    A pressure suppression containment system includes a containment vessel surrounding a reactor pressure vessel and defining a drywell therein containing a non-condensable gas. An enclosed wetwell pool is disposed inside the containment vessel, and a gravity driven cooling system (GDCS) pool is disposed above the wetwell pool in the containment vessel. The wetwell pool includes a plenum for receiving the non-condensable gas carried with steam from the drywell following a loss-of coolant-accident (LOCA). The wetwell plenum is vented to a plenum above the GDCS pool following the LOCA for suppressing pressure rise within the containment vessel. A method of operation includes channeling steam released into the drywell following the LOCA into the wetwell pool for cooling along with the non-condensable gas carried therewith. The GDCS pool is then drained by gravity, and the wetwell plenum is vented into the GDCS plenum for channeling the non-condensable gas thereto.

  3. Pressure suppression system

    DOE Patents [OSTI]

    Gluntz, D.M.

    1994-10-04T23:59:59.000Z

    A pressure suppression system includes a containment vessel surrounding a reactor pressure vessel and defining a drywell therein containing a non-condensable gas. An enclosed wetwell pool is disposed inside the containment vessel, and an enclosed gravity driven cooling system (GDCS) pool is disposed above the wetwell pool in the containment vessel. The GDCS pool includes a plenum for receiving through an inlet the non-condensable gas carried with steam from the drywell following a loss-of-coolant accident (LOCA). A condenser is disposed in the GDCS plenum for condensing the steam channeled therein and to trap the non-condensable gas therein. A method of operation includes draining the GDCS pool following the LOCA and channeling steam released into the drywell following the LOCA into the GDCS plenum for cooling along with the non-condensable gas carried therewith for trapping the gas therein. 3 figs.

  4. Pressure suppression system

    DOE Patents [OSTI]

    Gluntz, Douglas M. (San Jose, CA)

    1994-01-01T23:59:59.000Z

    A pressure suppression system includes a containment vessel surrounding a reactor pressure vessel and defining a drywell therein containing a non-condensable gas. An enclosed wetwell pool is disposed inside the containment vessel, and an enclosed gravity driven cooling system (GDCS) pool is disposed above the wetwell pool in the containment vessel. The GDCS pool includes a plenum for receiving through an inlet the non-condensable gas carried with steam from the drywell following a loss-of-coolant accident (LOCA). A condenser is disposed in the GDCS plenum for condensing the steam channeled therein and to trap the non-condensable gas therein. A method of operation includes draining the GDCS pool following the LOCA and channeling steam released into the drywell following the LOCA into the GDCS plenum for cooling along with the non-condensable gas carried therewith for trapping the gas therein.

  5. A formula for charmonium suppression

    SciTech Connect (OSTI)

    Pena, C., E-mail: pena@ift.uni.wroc.pl; Blaschke, D., E-mail: blaschke@ift.uni.wroc.pl [University of Wroclaw, Institute for Theoretical Physics (Poland)

    2012-07-15T23:59:59.000Z

    In this work a formula for charmonium suppression obtained by Matsui in 1989 is analytically generalized for the case of complex cc-barpotential described by a 3-dimensional and isotropic time-dependent harmonic oscillator (THO). It is suggested that under certain scheme the formula can be applied to describe J/{psi} suppression in heavy-ion collisions at CERN-SPS, RHIC, and LHC with the advantage of analytical tractability.

  6. Noise suppressing capillary separation system

    DOE Patents [OSTI]

    Yeung, E.S.; Xue, Y.

    1996-07-30T23:59:59.000Z

    A noise-suppressing capillary separation system for detecting the real-time presence or concentration of an analyte in a sample is provided. The system contains a capillary separation means through which the analyte is moved, a coherent light source that generates a beam which is split into a reference beam and a sample beam that irradiate the capillary, and a detector for detecting the reference beam and the sample beam light that transmits through the capillary. The laser beam is of a wavelength effective to be absorbed by a chromophore in the capillary. The system includes a noise suppressing system to improve performance and accuracy without signal averaging or multiple scans. 13 figs.

  7. Background Suppression Effects on Signal Estimation

    SciTech Connect (OSTI)

    Burr, Tom [Los Alamos National Laboratory

    2008-01-01T23:59:59.000Z

    Gamma detectors at border crossings are intended to detect illicit nuclear material. One performance challenge involves the fact that vehicles suppress the natural background, thus potentially reducing detection probability for threat items. Methods to adjust for background suppression have been considered in related but different settings. Here, methods to adjust for background suppression are tested in the context of signal estimation. Adjustment methods include several clustering options. We find that for the small-to-moderate suppression magnitudes exhibited in the analyzed data, suppression adjustment is only moderatel helpful in locating the signal peak, and in estimating its width or magnitude.

  8. Issues in Numerical Simulation of Fire Suppression

    SciTech Connect (OSTI)

    Tieszen, S.R.; Lopez, A.R.

    1999-04-12T23:59:59.000Z

    This paper outlines general physical and computational issues associated with performing numerical simulation of fire suppression. Fire suppression encompasses a broad range of chemistry and physics over a large range of time and length scales. The authors discuss the dominant physical/chemical processes important to fire suppression that must be captured by a fire suppression model to be of engineering usefulness. First-principles solutions are not possible due to computational limitations, even with the new generation of tera-flop computers. A basic strategy combining computational fluid dynamics (CFD) simulation techniques with sub-grid model approximations for processes that have length scales unresolvable by gridding is presented.

  9. Suppression of Stable Flies on Cattle

    E-Print Network [OSTI]

    Tomberlin, Jeffery K.

    2004-07-01T23:59:59.000Z

    Large populations of stable flies can substantially reduce the income of beef and dairy producers. This publication explains how to suppress stable flies effectively and economically....

  10. Quantifying precipitation suppression due to air Pollution

    E-Print Network [OSTI]

    Li, Zhanqing

    Quantifying precipitation suppression due to air Pollution First author: Amir Givati The Hebrew January 2004 #12;ABSTRACT: Urban and industrial air pollution has been shown qualitatively to suppress of the ratio of hill/coast precipitation during the 20th century in polluted areas in line with the increasing

  11. Propofol and sevoflurane induce distinct burst suppression patterns in rats

    E-Print Network [OSTI]

    Westover, M. Brandon

    Burst suppression is an EEG pattern characterized by alternating periods of high-amplitude activity (bursts) and relatively low amplitude activity (suppressions). Burst suppression can arise from several different pathological ...

  12. aircraft halon bottles: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Vassilis Kouroublakis, Engineering Websites Summary: on the environment during their life cycle. The shape of the bottle is formed by separating it into a number of parts,...

  13. THEORETICAL ISSUES IN J/PSI SUPPRESSION.

    SciTech Connect (OSTI)

    KHARZEEV,D.

    2006-11-14T23:59:59.000Z

    Two decades ago Matsui and Satz suggested that Debye screening in the quark-gluon plasma would result in J/{psi} suppression in heavy ion collisions. Much has happened in the subsequent years, and the picture of quark-gluon plasma at present is rapidly evolving - what does it imply for the J/{psi} suppression? What are the recent RHIC and SPS results trying to tell us? What else has to be done? This talk is an attempt to address these questions.

  14. Water Mist Suppression in Conjunction with Displacement

    E-Print Network [OSTI]

    Hickman, Mark

    Water Mist Suppression in Conjunction with Displacement Ventilation By Benjamin Piers Hume-2758 #12;#12;Displacement Water Mist System Masters of Fire Engineering Thesis 2003 i A man of genius makes Water Mist System Masters of Fire Engineering Thesis 2003 ii #12;Displacement Water Mist System Masters

  15. Benchmark enclosure fire suppression experiments - phase 1 test report.

    SciTech Connect (OSTI)

    Figueroa, Victor G.; Nichols, Robert Thomas; Blanchat, Thomas K.

    2007-06-01T23:59:59.000Z

    A series of fire benchmark water suppression tests were performed that may provide guidance for dispersal systems for the protection of high value assets. The test results provide boundary and temporal data necessary for water spray suppression model development and validation. A review of fire suppression in presented for both gaseous suppression and water mist fire suppression. The experimental setup and procedure for gathering water suppression performance data are shown. Characteristics of the nozzles used in the testing are presented. Results of the experiments are discussed.

  16. CHAPTER: In-Situ Characterization of Stimulating Microelectrode Arrays: Study of an Idealized Structure Based on Argus II Retinal implantsBOOK TITLE: Implantable Neural Prostheses 2: Techniques and Engineering Approaches, D.M. Zhou and E. Greenbaum, Eds., Springer, NY 2009

    SciTech Connect (OSTI)

    Greenbaum, Elias [ORNL; Sanders, Charlene A [ORNL; Kandagor, Vincent [ORNL

    2010-01-01T23:59:59.000Z

    The development of a retinal prosthesis for artificial sight includes a study of the factors affecting the structural and functional stability of chronically implanted microelectrode arrays. Although neuron depolarization and propagation of electrical signals have been studied for nearly a century, the use of multielectrode stimulation as a proposed therapy to treat blindness is a frontier area of modern ophthalmology research. Mapping and characterizing the topographic information contained in the electric field potentials and understanding how this information is transmitted and interpreted in the visual cortex is still very much a work in progress. In order to characterize the electrical field patterns generated by the device, an in vitro prototype that mimics several of the physical and chemical parameters of the in vivo visual implant device was fabricated. We carried out multiple electrical measurements in a model 'eye,' beginning with a single electrode, followed by a 9-electrode array structure, both idealized components based on the Argus II retinal implants. Correlating the information contained in the topographic features of the electric fields with psychophysical testing in patients may help reduce the time required for patients to convert the electrical patterns into graphic signals.

  17. Metasurfaces for suppressing reflection over broadband

    E-Print Network [OSTI]

    Patra, Anuradha; Nagarajan, Arvind; Achanta, Venu Gopal

    2015-01-01T23:59:59.000Z

    Surfaces patterned with arrays of quasi-periodic air holes having conical depth profile have been studied for their effectiveness in suppressing air-substrate reflection in the wavelength range of 450-1350 nm (limited by our measurement). The role of quasi-periodic air-hole pattern, depth of holes and launch angle on the observed antireflection behavior are investigated. The average optical transmittance of the patterned quartz substrate at near normal incidence is more than 97% and reflectance is less than 2%. Patterned quartz surfaces with 450 nm thin graded rarefaction region maintain the antireflective property up to 30{\\deg} (limited by our measurements) angle of incidence.

  18. The development and evaluation of water-mist fire extinguishing systems

    SciTech Connect (OSTI)

    Beason, D.G.; Staggs, K.J.

    1994-08-01T23:59:59.000Z

    Fire protection for underfloor space is primarily provided by Halon 1301 which has proven to be very effective. However, due to the link between halons and the possible depletion of the stratospheric ozone layer, plans have been implemented to eventually phase out Halon 1301 and 1211. In September 1987 the Montreal Protocol concerning chlorofluorocarbons (CFC) and halons was signed by the United States, the European Economic Community, and 23 other nations. The Montreal Protocol calls for freezing halon production at 1986 levels. Because the majority of underfloor fire protection at Lawrence Livermore National Laboratory (LLNL), as well as other Department of Energy (DOE) sites, is either Halon 1301 or sprinklers, some other means of suppression will have to be developed and verified. The potential loss to facilities housing computer or control rooms damaged by underfloor fires can be extreme. These losses would not only include hardware and software replacement costs, but also lost computing and control capability. Here at LLNL technical research in a facility could be severely affected. Recent studies conducted by the Fire Research Discipline of the Special Projects Division have shown that severe fires fueled by cable insulation can develop within as little as a 6-in-high underfloor space (even with mechanical ventilation shut off). Studies also show that conventional sprinklers may not be effective in preventing this destruction. Therefore, we are investigating the water-mist fire extinguishing system as an alternative to Halon 1301 and sprinklers.

  19. Suppression of Magnetic State Decoherence Using Ultrafast Optical Pulses

    E-Print Network [OSTI]

    C. Search; P. R. Berman

    2000-03-01T23:59:59.000Z

    It is shown that the magnetic state decoherence produced by collisions in a thermal vapor can be suppressed by the application of a train of ultrafast optical pulses.

  20. acids suppresses diethylnitrosamine-induced: Topics by E-print...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topic Index 1 Suppression of rice methane emission by sulfate deposition in simulated acid rain Geosciences Websites Summary: from rice agriculture. Emissions from rice plants...

  1. acid suppression therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2006-01-01 2 Suppression of rice methane emission by sulfate deposition in simulated acid rain Geosciences Websites Summary: from rice agriculture. Emissions from rice plants...

  2. acid suppression trial: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    1997-01-01 2 Suppression of rice methane emission by sulfate deposition in simulated acid rain Geosciences Websites Summary: from rice agriculture. Emissions from rice plants...

  3. acid suppression predict: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Davis, Matt 2 Suppression of rice methane emission by sulfate deposition in simulated acid rain Geosciences Websites Summary: from rice agriculture. Emissions from rice plants...

  4. Fire Foe: A Glovebox Fire Suppression System | Department of...

    Broader source: Energy.gov (indexed) [DOE]

    Envirogel Extinguishing Agent NRTL Qualification Fire Test Proof-of-Concept Testing Seismic Reliability Fire Foe: A Glovebox Fire Suppression System More Documents &...

  5. Suppressive effects of ketamine on macrophage functions

    SciTech Connect (OSTI)

    Chang Yi [Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan (China); Department of Anesthesiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China); Chen, T.-L. [Department of Anesthesiology, Wan-Fang Hospital, College of Medicine, Taipei Medical University, Taipei, Taiwan (China); Sheu, J.-R. [Department of Anesthesiology, Wan-Fang Hospital, College of Medicine, Taipei Medical University, Taipei, Taiwan (China); Chen, R.-M. [Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan (China) and Department of Anesthesiology, Wan-Fang Hospital, College of Medicine, Taipei Medical University, Taipei, Taiwan (China)]. E-mail: rmchen@tmu.edu.tw

    2005-04-01T23:59:59.000Z

    Ketamine is an intravenous anesthetic agent. Clinically, induction of anesthesia with ketamine can cause immunosuppression. Macrophages play important roles in host defense. In this study, we attempted to evaluate the effects of ketamine on macrophage functions and its possible mechanism using mouse macrophage-like Raw 264.7 cells as the experimental model. Exposure of macrophages to 10 and 100 {mu}M ketamine, which correspond to 0.1 and 1 times the clinically relevant concentration, for 1, 6, and 24 h had no effect on cell viability or lactate dehydrogenase release. When the administered concentration reached 1000 {mu}M, ketamine caused a release of lactate dehydrogenase and cell death. Ketamine, at 10 and 100 {mu}M, did not affect the chemotactic activity of macrophages. Administration of 1000 {mu}M ketamine in macrophages resulted in a decrease in cell migration. Treatment of macrophages with ketamine reduced phagocytic activities. The oxidative ability of macrophages was suppressed by ketamine. Treatment with lipopolysaccharide induced TNF-{alpha}, IL-1{beta}, and IL-6 mRNA in macrophages. Administration of ketamine alone did not influence TNF-{alpha}, IL-1{beta}, or IL-6 mRNA production. Meanwhile, cotreatment with ketamine and lipopolysaccharide significantly inhibited lipopolysaccharide-induced TNF-{alpha}, IL-1{beta}, and IL-6 mRNA levels. Exposure to ketamine led to a decrease in the mitochondrial membrane potential. However, the activity of mitochondrial complex I NADH dehydrogenase was not affected by ketamine. This study shows that a clinically relevant concentration of ketamine (100 {mu}M) can suppress macrophage function of phagocytosis, its oxidative ability, and inflammatory cytokine production possibly via reduction of the mitochondrial membrane potential instead of direct cellular toxicity.

  6. Speculative Execution Exception Recovery Write-back Suppression

    E-Print Network [OSTI]

    Mahlke, Scott A.

    Speculative Execution Exception Recovery using Write-back Suppression Roger A. Bringmann Scott A or extra register pressure. This paper introduces a new architecture scheme referred to as write-back that with a modest amount of hardware, write- back suppression supports accurate reporting and handling of exceptions

  7. antigens suppresses murine: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in adulthood of autoreactive T cells specific to that antigen. The renal-specific ... Marshall, Naomi Jane 2009-01-01 17 Thymosin Beta 4 has tumor suppressive effects and its...

  8. Scanning probe microscopy with inherent disturbance suppression using micromechanical systems

    E-Print Network [OSTI]

    Sparks, Andrew William, 1977-

    2005-01-01T23:59:59.000Z

    All scanning probe microscopes (SPMs) are affected by disturbances, or mechanical noise, in their environments which can limit their imaging resolution. This thesis introduces a general approach for suppressing out-of-plane ...

  9. Nuclear Suppression of Dileptons at Large xF

    E-Print Network [OSTI]

    J. Cepila; J. Nemchik

    2009-10-09T23:59:59.000Z

    We study a significant nuclear suppression of the relative production rates (p(d)+A)/(p+d(p)) for the Drell-Yan process at large Feynman xF. Since this is the region of minimal values for the light-front momentum fraction variable x2 in the target nucleus, it is tempting to interpret this as a manifestation of coherence or of a Color Glass Condensate. We demonstrate, however, that this suppression mechanism is governed by the energy conservation restrictions in multiple parton rescatterings in nuclear matter. To eliminate nuclear shadowing effects coming from the coherence, we calculate nuclear suppression in the light-cone dipole approach at large dilepton masses and at energy accessible at FNAL. Our calculations are in a good agreement with data from the E772 experiment. Using the same mechanism we predict also nuclear suppression at forward rapidities in the RHIC energy range.

  10. Global microRNA depletion suppresses tumor angiogenesis

    E-Print Network [OSTI]

    Chen, Sidi

    MicroRNAs delicately regulate the balance of angiogenesis. Here we show that depletion of all microRNAs suppresses tumor angiogenesis. We generated microRNA-deficient tumors by knocking out Dicer1. These tumors are highly ...

  11. Suppression of Dilepton Production in Hot Hadronic Matter

    E-Print Network [OSTI]

    Song, C.; Lee, S. H.; Ko, Che Ming.

    1995-01-01T23:59:59.000Z

    -meson resonance is suppressed as a result of the modification of the pion electromagnetic form factor at finite temperature. The relevance of this phenomenon to the partial restoration of chiral symmetry in hot hadronic matter is discussed....

  12. Multi-band OFDM UWB receiver with narrowband interference suppression 

    E-Print Network [OSTI]

    Kelleci, Burak

    2009-05-15T23:59:59.000Z

    A multi band orthogonal frequency division multiplexing (MB-OFDM) compatible ultra wideband (UWB) receiver with narrowband interference (NBI) suppression capability is presented. The average transmit power of UWB system ...

  13. Suppression of pool fires with HRC-125 in a simulated engine nacelle.

    SciTech Connect (OSTI)

    Keyser, David R. (INS, Inc., Lexington Park, MD); Hewson, John C.

    2007-06-01T23:59:59.000Z

    CFD simulations are conducted to predict the distribution of fire suppressant in an engine nacelle and to predict the suppression of pool fires by the application of this suppressant. In the baseline configuration, which is based on an installed system, suppressant is injected through four nozzles at a rate fast enough to suppress all simulated pool fires. Variations that reduce the mass of the suppression system (reducing the impact of the suppression system on meeting mission needs) are considered, including a reduction in the rate of suppressant injection, a reduction in the mass of suppressant and a reduction in the number of nozzles. In general, these variations should work to reduce the effectiveness of the suppression system, but the CFD results point out certain changes that have negligible impact, at least for the range of phenomena considered here. The results are compared with measurements where available. Comparisons with suppressant measurements are reasonable. A series of twenty-three fire suppression tests were conducted to check the predictions. The pre-test predictions were generally successful in identifying the range of successful suppression tests. In two separate cases, each where one nozzle of the suppression system was capped, the simulation results did indicate a failure to suppress for a condition where the tests indicated successful suppression. When the test-suppressant discharge rate was reduced by roughly 25%, the tests were in agreement with the predictions. That is, the simulations predict a failure to suppress slightly before observed in these cases.

  14. Climate Dependency of Tree Growth Suppressed by Acid Deposition

    E-Print Network [OSTI]

    Lapenas, Andrei G.

    uptake). These soil changes coincided with decreased diameter growth and a suppression of climateClimate Dependency of Tree Growth Suppressed by Acid Deposition Effects on Soils in Northwest Russia G R E G O R Y B . L A W R E N C E , * , A N D R E I G . L A P E N I S , D A N B E R G G R E N

  15. Selection of hydrate suppression methods for gas streams

    SciTech Connect (OSTI)

    Behrens, S.D.; Covington, K.K.; Collie, J.T. III

    1999-07-01T23:59:59.000Z

    This paper will discuss and compare the methods used to suppress hydrate formation in natural gas streams. Included in the comparison will be regenerated systems using ethylene glycol and non-regenerated systems using methanol. A comparison will be made between the quantities of methanol and ethylene glycol required to achieve a given a suppression. A discussion of BTEX emissions resulting from the ethylene glycol regenerator along with the effect or process variables on these emissions is also given.

  16. Reactor Neutrino Flux Uncertainty Suppression on Multiple Detector Experiments

    E-Print Network [OSTI]

    Andi Cucoanes; Pau Novella; Anatael Cabrera; Muriel Fallot; Anthony Onillon; Michel Obolensky; Frederic Yermia

    2015-01-02T23:59:59.000Z

    This publication provides a coherent treatment for the reactor neutrino flux uncertainties suppression, specially focussed on the latest $\\theta_{13}$ measurement. The treatment starts with single detector in single reactor site, most relevant for all reactor experiments beyond $\\theta_{13}$. We demonstrate there is no trivial error cancellation, thus the flux systematic error can remain dominant even after the adoption of multi-detector configurations. However, three mechanisms for flux error suppression have been identified and calculated in the context of Double Chooz, Daya Bay and RENO sites. Our analysis computes the error {\\it suppression fraction} using simplified scenarios to maximise relative comparison among experiments. We have validated the only mechanism exploited so far by experiments to improve the precision of the published $\\theta_{13}$. The other two newly identified mechanisms could lead to total error flux cancellation under specific conditions and are expected to have major implications on the global $\\theta_{13}$ knowledge today. First, Double Chooz, in its final configuration, is the only experiment benefiting from a negligible reactor flux error due to a $\\sim$90\\% geometrical suppression. Second, Daya Bay and RENO could benefit from their partial geometrical cancellation, yielding a potential $\\sim$50\\% error suppression, thus significantly improving the global $\\theta_{13}$ precision today. And third, we illustrate the rationale behind further error suppression upon the exploitation of the inter-reactor error correlations, so far neglected. So, our publication is a key step forward in the context of high precision neutrino reactor experiments providing insight on the suppression of their intrinsic flux error uncertainty, thus affecting past and current experimental results, as well as the design of future experiments.

  17. Arsenite suppression of BMP signaling in human keratinocytes

    SciTech Connect (OSTI)

    Phillips, Marjorie A.; Qin, Qin [Department of Environmental Toxicology, University of California, Davis, CA 95616-8588 (United States); Hu, Qin; Zhao, Bin [State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085 (China); Rice, Robert H., E-mail: rhrice@ucdavis.edu [Department of Environmental Toxicology, University of California, Davis, CA 95616-8588 (United States)

    2013-06-15T23:59:59.000Z

    Arsenic, a human skin carcinogen, suppresses differentiation of cultured keratinocytes. Exploring the mechanism of this suppression revealed that BMP-6 greatly increased levels of mRNA for keratins 1 and 10, two of the earliest differentiation markers expressed, a process prevented by co-treatment with arsenite. BMP also stimulated, and arsenite suppressed, mRNA for FOXN1, an important transcription factor driving early keratinocyte differentiation. Keratin mRNAs increased slowly after BMP-6 addition, suggesting they are indirect transcriptional targets. Inhibition of Notch1 activation blocked BMP induction of keratins 1 and 10, while FOXN1 induction was largely unaffected. Supporting a requirement for Notch1 signaling in keratin induction, BMP increased levels of activated Notch1, which was blocked by arsenite. BMP also greatly decreased active ERK, while co-treatment with arsenite maintained active ERK. Inhibition of ERK signaling mimicked BMP by inducing keratin and FOXN1 mRNAs and by increasing active Notch1, effects blocked by arsenite. Of 6 dual-specificity phosphatases (DUSPs) targeting ERK, two were induced by BMP unless prevented by simultaneous exposure to arsenite and EGF. Knockdown of DUSP2 or DUSP14 using shRNAs greatly reduced FOXN1 and keratins 1 and 10 mRNA levels and their induction by BMP. Knockdown also decreased activated Notch1, keratin 1 and keratin 10 protein levels, both in the presence and absence of BMP. Thus, one of the earliest effects of BMP is induction of DUSPs, which increases FOXN1 transcription factor and activates Notch1, both required for keratin gene expression. Arsenite prevents this cascade by maintaining ERK signaling, at least in part by suppressing DUSP expression. - Highlights: • BMP induces FOXN1 transcription. • BMP induces DUSP2 and DUSP14, suppressing ERK activation. • Arsenite suppresses levels of phosphorylated Smad1/5 and FOXN1 and DUSP mRNA. • These actions rationalize arsenite suppression of keratinocyte differentiation.

  18. A simplified model of decontamination by BWR steam suppression pools

    SciTech Connect (OSTI)

    Powers, D.A.

    1997-05-01T23:59:59.000Z

    Phenomena that can decontaminate aerosol-laden gases sparging through steam suppression pools of boiling water reactors during reactor accidents are described. Uncertainties in aerosol properties, aerosol behavior within gas bubbles, and bubble behavior in plumes affect predictions of decontamination by steam suppression pools. Uncertainties in the boundary and initial conditions that are dictated by the progression of severe reactor accidents and that will affect predictions of decontamination by steam suppression pools are discussed. Ten parameters that characterize boundary and initial condition uncertainties, nine parameters that characterize aerosol property and behavior uncertainties, and eleven parameters that characterize uncertainties in the behavior of bubbles in steam suppression pools are identified. Ranges for the values of these parameters and subjective probability distributions for parametric values within the ranges are defined. These uncertain parameters are used in Monte Carlo uncertainty analyses to develop uncertainty distributions for the decontamination that can be achieved by steam suppression pools and the size distribution of aerosols that do emerge from such pools. A simplified model of decontamination by steam suppression pools is developed by correlating features of the uncertainty distributions for total decontamination factor, DF(total), mean size of emerging aerosol particles, d{sub p}, and the standard deviation of the emerging aerosol size distribution, {sigma}, with pool depth, H. Correlations of the median values of the uncertainty distributions are suggested as the best estimate of decontamination by suppression pools. Correlations of the 10 percentile and 90 percentile values of the uncertainty distributions characterize the uncertainty in the best estimates. 295 refs., 121 figs., 113 tabs.

  19. Suppression of radio frequency knock out in stacked beams by phase shifting the betatron oscillations

    E-Print Network [OSTI]

    Terwilliger, K M

    1957-01-01T23:59:59.000Z

    Suppression of radio frequency knock out in stacked beams by phase shifting the betatron oscillations

  20. Fire suppression efficiency screening using a counterflow cylindrical burner

    SciTech Connect (OSTI)

    Yang, J.C.; Donnelly, M.K.; Prive, N.; Grosshandler, W.L.

    1999-07-01T23:59:59.000Z

    The design and validation of a counterflow cylindrical burner for fire suppression efficiency screening are described. The stability limits of the burner were mapped using various fuel (propane) and oxidizer (air) flows. The stability envelopes compared favorably with those reported in the literature. The apparatus was characterized using inert gases (argon, helium, and nitrogen), and the relative fire suppression efficiency ranking of these three gases was found to be commensurate with that from cup-burner tests. For liquid suppression experiments, a piezoelectric droplet generator was used to form droplets (<100 {micro}m). Water was used as a representative liquid suppressant to study the feasibility of using such a burner for screening liquid agents. Extinction was facilitated with the addition of water droplets, and the effect of water became more pronounced when its application rate was increased. Suppression experiments using water with and without nitrogen dilution in the oxidizer stream were also performed. Flame extinction due to the combined effect of water and nitrogen dilution was demonstrated.

  1. $J/?$ suppression in the threshold model and QGP formation time

    E-Print Network [OSTI]

    A. K. Chaudhuri

    2007-09-03T23:59:59.000Z

    In the QGP motivated threshold model, in addition to the normal nuclear absorption, $J/\\psi$'s are subjected to an additional "anomalous" suppression. We have analysed the recently published PHENIX data on the participant number dependence of the nuclear modification factor for $J/\\psi$'s in Au+Au collisions and extracted the anomalous suppression required to explain the data. At mid rapidity $J/\\psi$'s are anomalously suppressed only above a threshold density $n_c$=3.73 fm$^{-2}$. The forward rapidity data on the otherhand require that $J/\\psi$'s are continuously "anomalously" suppressed. The analysis strongly indicate that in mid rapidity $J/\\psi$'s are suppressed in a deconfined medium. Using the PHENIX data on the participant number dependence of the Bjorken energy density, we have also estimated the QGP formation time. For critical temperature $T_c$=192 MeV, estimated QGP formation time ranges between 0.06-0.08 fm/c.

  2. Reactor Neutrino Flux Uncertainty Suppression on Multiple Detector Experiments

    E-Print Network [OSTI]

    Cucoanes, Andi; Cabrera, Anatael; Fallot, Muriel; Onillon, Anthony; Obolensky, Michel; Yermia, Frederic

    2015-01-01T23:59:59.000Z

    This publication provides a coherent treatment for the reactor neutrino flux uncertainties suppression, specially focussed on the latest $\\theta_{13}$ measurement. The treatment starts with single detector in single reactor site, most relevant for all reactor experiments beyond $\\theta_{13}$. We demonstrate there is no trivial error cancellation, thus the flux systematic error can remain dominant even after the adoption of multi-detector configurations. However, three mechanisms for flux error suppression have been identified and calculated in the context of Double Chooz, Daya Bay and RENO sites. Our analysis computes the error {\\it suppression fraction} using simplified scenarios to maximise relative comparison among experiments. We have validated the only mechanism exploited so far by experiments to improve the precision of the published $\\theta_{13}$. The other two newly identified mechanisms could lead to total error flux cancellation under specific conditions and are expected to have major implications o...

  3. Alcohol-induced suppression of the humoral immune response

    SciTech Connect (OSTI)

    Stolen, J.S.; Draxler, S.; Nagle, J.J.

    1985-01-01T23:59:59.000Z

    The authors report here that summer flounder (Paralichthys dentatus) pretreated by injection of a small amount of the common alcohol, ethanol, or ethanol containing PCB, showed complete suppression of the immune response to a formalin-killed sewage sludge isolate of the human enteric bacteria, E. coli. The unresponsiveness persisted for up to 42 days after injection of bacteria. Demonstrable agglutinating antibody to E. coli was seen in unpretreated fish after seven days. A second injection of bacteria 42 days after the first in pretreated fish, now resulted in immune responsiveness although the magnitude of the response resembled a primary response, indicating that memory to the first injection was also suppressed. Slightly lower responses were seen in the groups of fish injected with ethanol containing the PCB Aroclor 1254 when compared with those given ethanol alone, but the major suppression was alcohol-induced.

  4. An alternative model of jet suppression at RHIC energies

    E-Print Network [OSTI]

    Lietava, R; Pisútová, N; Tomasik, Boris; Lietava, Roman; Pisut, Jan; Pisutova, Neva; Tomasik, Boris

    2003-01-01T23:59:59.000Z

    We propose a simple Glauber-type mechanism for suppression of jet production up to transverse momenta of about 10 GeV/c at RHIC. For processes in this kinematic region, the formation time is smaller than the interval between two successive hard partonic collisions and the subsequent collision influences the jet production. Number of jets then roughly scales with the number of participants. Proportionality to the number of binary collisions is recovered for very high transverse momenta. The model predicts suppression of jet production in d+Au collisions at RHIC.

  5. Viscoelastic Suppression of Gravity-Driven Counterflow Instability

    E-Print Network [OSTI]

    Beiersdorfer, P; Layne, D; Magee, E W

    2010-01-01T23:59:59.000Z

    Attempts to achieve ``top kill'' of actively flowing oil wells by insertion of dense drilling ``muds'', i.e., slurries of dense minerals, from above will fail if the Kelvin-Helmholtz instability in the gravity-driven counterflow produces turbulence that breaks up the denser fluid into small droplets. Here we estimate the droplet size to be sub-mm for fast flows and suggest the addition of a shear-thickening polymer to suppress turbulence. Laboratory experiments show a progression from droplet formation to complete turbulence suppression at the relevant high velocities, illustrating rich new physics accessible by using a shear-thickening liquid in gravity driven counter-streaming flows.

  6. An alternative model of jet suppression at RHIC energies

    E-Print Network [OSTI]

    Roman Lietava; Jan Pisut; Neva Pisutova; Boris Tomasik

    2003-02-10T23:59:59.000Z

    We propose a simple Glauber-type mechanism for suppression of jet production up to transverse momenta of about 10 GeV/c at RHIC. For processes in this kinematic region, the formation time is smaller than the interval between two successive hard partonic collisions and the subsequent collision influences the jet production. Number of jets then roughly scales with the number of participants. Proportionality to the number of binary collisions is recovered for very high transverse momenta. The model predicts suppression of jet production in d+Au collisions at RHIC.

  7. Suppressing Proton Decay in Theories with Localised Fermions

    E-Print Network [OSTI]

    Bobby S. Acharya; Roberto Valandro

    2006-08-01T23:59:59.000Z

    We calculate the contribution to the proton decay amplitude from Kaluza-Klein lepto-quarks in theories with extra dimensions, localised fermions and gauge fields which propagate in the bulk. Such models naturally occur within the context of M-theory. In SU(5) models we show that carefully including all such modes gives a distinctive pattern of decays through various channels including a strong suppression of decays into neutrinos or right handed positrons. By contrast there is no such suppression for SO(10).

  8. Occupant Classification System for Automotive Airbag Suppression Michael E. Farmer

    E-Print Network [OSTI]

    Occupant Classification System for Automotive Airbag Suppression Michael E. Farmer§ and Anil K@cse.msu.edu Abstract The introduction of airbags into automobiles has significantly improved the safety of the occupants. Unfortunately, airbags can also cause fatal injuries if the occupant is a child smaller (in

  9. SUPPRESSION OF DIELECTRONIC RECOMBINATION DUE TO FINITE DENSITY EFFECTS

    SciTech Connect (OSTI)

    Nikolic, D.; Gorczyca, T. W.; Korista, K. T. [Western Michigan University, Kalamazoo, MI (United States); Ferland, G. J. [University of Kentucky, Lexington, KY (United States); Badnell, N. R. [University of Strathclyde, Glasgow (United Kingdom)

    2013-05-01T23:59:59.000Z

    We have developed a general model for determining density-dependent effective dielectronic recombination (DR) rate coefficients in order to explore finite-density effects on the ionization balance of plasmas. Our model consists of multiplying by a suppression factor those highly-accurate total zero-density DR rate coefficients which have been produced from state-of-the-art theoretical calculations and which have been benchmarked by experiment. The suppression factor is based upon earlier detailed collision-radiative calculations which were made for a wide range of ions at various densities and temperatures, but used a simplified treatment of DR. A general suppression formula is then developed as a function of isoelectronic sequence, charge, density, and temperature. These density-dependent effective DR rate coefficients are then used in the plasma simulation code Cloudy to compute ionization balance curves for both collisionally ionized and photoionized plasmas at very low (n{sub e} = 1 cm{sup -3}) and finite (n{sub e} = 10{sup 10} cm{sup -3}) densities. We find that the denser case is significantly more ionized due to suppression of DR, warranting further studies of density effects on DR by detailed collisional-radiative calculations which utilize state-of-the-art partial DR rate coefficients. This is expected to impact the predictions of the ionization balance in denser cosmic gases such as those found in nova and supernova shells, accretion disks, and the broad emission line regions in active galactic nuclei.

  10. FINAL REPORT FOR PSerc PROJECT Avoiding and Suppressing

    E-Print Network [OSTI]

    Dobson, Ian

    FINAL REPORT FOR PSerc PROJECT Avoiding and Suppressing Oscillations December 1999 POWER SYSTEMS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 1.4 Summary guide to this report . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 1.4 Arbitrary topology networks with high order machine models . . . . . . . . . 43 5.5 The eigenvalue solution

  11. Suppressed serum prolactin in sinoaortic-denervated rats

    SciTech Connect (OSTI)

    Alexander, N.; Melmed, S.; Morris, M.

    1987-02-01T23:59:59.000Z

    The authors investigated the effect of arterial baroreceptor deafferentation on serum and pituitary prolactin (PRL) and on catecholamines in median eminence (ME) and anterior and posterior pituitaries. Male Wistar rats were sinoaortic denervated (SAD) or sham operated (SO). Three days after surgery serum prolactin, measured by radioimmunoassay, was suppressed in SAD rats, and dopamine (DA) and norepinephrine (NE) concentrations, measured by radioenzymatic or high-performance liquid chromatography electron capture methods, were significantly reduced in ME of SAD rats. Simultaneously, anterior pituitary of SAD rats had significant increases in both catecholamines, whereas posterior pituitary showed no changes. Four hours after surgery serum PRL was also reduced in SAD rats, but no changes in ME catecholamines were found. Mean arterial pressure (MAP) and heart rate were measured before and after injection of bromocriptine in SAD and SO rats 3 days after surgery. Bromocriptine markedly suppressed serum PRL in both groups and reduced MAP from 144 +/- 10 to 84 +/- 5 and from 116 +/- 2 to 99 +/- 3 in SAD and SO rats, respectively; heart rate was reduced in SAD rats. They conclude that the SAD rat is a model of hypertension with suppressed serum PRL and that interruption of arterial baroreceptor nerves suppresses PRL secretion probably by modulating tuberoinfundibular turnover of catecholamines.

  12. Range Sidelobe Suppression in a Desired Doppler Interval

    E-Print Network [OSTI]

    Pezeshki, Ali

    is sensitive to Doppler effect. Off the zero- Doppler axis the ambiguity function of Golay pairs of phase codedRange Sidelobe Suppression in a Desired Doppler Interval Yuejie Chi,1 Ali Pezeshki,2 Robert--We present a novel method of constructing a Doppler resilient pulse train of Golay complementary waveforms

  13. Seismic shape parameters estimation and ground-roll suppression using

    E-Print Network [OSTI]

    Spagnolini, Umberto

    Seismic shape parameters estimation and ground-roll suppression using vector-sensor beamforming the problem of estimating the shape parameters of seismic wavefields in linear arrays. The purpose of the subsurface layers from the seismic wavefields registered by surface sensors. However, only the waves

  14. Low Dose Suppression of Neoplastic Transformation in Vitro

    SciTech Connect (OSTI)

    John Leslie Redpath

    2012-05-01T23:59:59.000Z

    This grant was to study the low dose suppression of neoplastic transformation in vitro and the shape of the dose-response curve at low doses and dose-rates of ionizing radiation. Previous findings had indicated a suppression of transformation at dose <10cGy of low-LET radiation when delivered at high dose-rate. The present study indicates that such suppression extends out to doses in excess of 100cGy when the dose (from I-125 photons) is delivered at dose-rates as low as 0.2 mGy/min and out to in excess of {approx}25cGy the highest dose studied at the very low dose-rate of 0.5 mGy/day. We also examined dose-rate effects for high energy protons (which are a low-LET radiation) and suppression was evident below {approx}10cGy for high dose-rate delivery and at least out to 50cGy for low dose-rate (20cGy/h) delivery. Finally, we also examined the effect of low doses of 1 GeV/n iron ions (a high-LET radiation) delivered at high dose-rate on transformation at low doses and found a suppression below {approx}10cGy that could be attributable to an adaptive response in bystander cells induced by the associated low-LET delta rays. These results have implications for cancer risk assessment at low doses.

  15. The optimal suppression of a low-cost technology by a durable-good monopoly

    E-Print Network [OSTI]

    Karp, Larry; Perloff, Jeffrey M

    1994-01-01T23:59:59.000Z

    SUPPRESSION OF A LOW-COST TECHNOLOGY BY A DURABLE-GOODsuppression of a low-cost technology by a durable-goodSuppression of a Low-Cost Technology by a Durable-Good

  16. Kalman filtering to suppress spurious signals in Adaptive Optics control

    SciTech Connect (OSTI)

    Poyneer, L; Veran, J P

    2010-03-29T23:59:59.000Z

    In many scenarios, an Adaptive Optics (AO) control system operates in the presence of temporally non-white noise. We use a Kalman filter with a state space formulation that allows suppression of this colored noise, hence improving residual error over the case where the noise is assumed to be white. We demonstrate the effectiveness of this new filter in the case of the estimated Gemini Planet Imager tip-tilt environment, where there are both common-path and non-common path vibrations. We discuss how this same framework can also be used to suppress spatial aliasing during predictive wavefront control assuming frozen flow in a low-order AO system without a spatially filtered wavefront sensor, and present experimental measurements from Altair that clearly reveal these aliased components.

  17. Optical analog of Rabi oscillation suppression due to atomic motion

    E-Print Network [OSTI]

    J. G. Muga; B. Navarro

    2005-05-13T23:59:59.000Z

    The Rabi oscillations of a two-level atom illuminated by a laser on resonance with the atomic transition may be suppressed by the atomic motion through averaging or filtering mechanisms. The optical analogs of these velocity effects are described. The two atomic levels correspond in the optical analogy to orthogonal polarizations of light and the Rabi oscillations to polarization oscillations in a medium which is optically active, naturally or due to a magnetic field. In the later case, the two orthogonal polarizations could be selected by choosing the orientation of the magnetic field, and one of them be filtered out. It is argued that the time-dependent optical polarization oscillations or their suppression are observable with current technology.

  18. Suppression MHD instabilities by IBW heating in HT-7 Tokamak

    E-Print Network [OSTI]

    C. M. Qin; Y. P. Zhao; X. J. Zhang; P. Xu; Y. Yang; the HT-7 team

    2010-01-21T23:59:59.000Z

    In HT-7 tokamak, the m= 2/1 tearing mode can be effectively suppressed by the ion bernstein wave (IBW) when the location of power deposition is near the q=2 rational surface. Off-axis electron heating and greatly increase of electron density was observed, in the meantime, the particle confinement appears to be improved with the increased of the central line averaged electron density and the drop of Da emission. Induced large ne gradients and pressures were spatially correlated with the IBW deposition profile by theoretical calculation >. It is suggested that off-axis IBW heating modifies the electron pressure profile, and so the current density profile could be redistributed resulting in the suppression of the magnetohydrodynamics (MHD) instability. It provides an integrated way for making combined effects on both the stabilization of tearing modes and controlling of pressure profile.

  19. Analysis of Shot Noise Suppression for Electron Beams

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Ratner, Daniel; Huang, Zhirong; Stupakov, Gennady

    2015-02-02T23:59:59.000Z

    Shot noise can affect the performance of free-electron lasers (FELs) by driving instabilities (e.g., the microbunching instability) or by competing with seeded density modulations. Recent papers have proposed suppressing shot noise to enhance FEL performance. In this paper we use a onedimensional (1D) model to calculate the noise amplification from an energy modulation (e.g., electron interactions from space charge or undulator radiation) followed by a dispersive section. We show that, for a broad class of interactions, selecting the correct dispersive strength suppresses shot noise across a wide range of frequencies. The final noise level depends on the beam’s energy spread and the properties of the interaction potential. We confirm and illustrate our analytical results with 1D simulations.

  20. Nuclear absorption and $J/?$ suppression in Pb+Pb collisions

    E-Print Network [OSTI]

    A. K. Chaudhuri

    2002-03-18T23:59:59.000Z

    We have analyzed the NA58 data on $J/\\psi$ suppression in Pb+Pb collisions. $J/\\psi$ production is assumed to be a two step process, (i) formation of $c\\bar{c}$ pair, which is accurately calculable in QCD and (ii) formation of $J/\\psi$ meson from the $c\\bar{c}$ pair, which can be conveniently parameterized. In a pA/AA collision, a $c\\bar{c}$ pair gain relative square momentum as it passes through the nuclear medium and some of the $c\\bar{c}$ pairs can gain enough momentum to cross the threshold to become an open charm meson, leading to suppression in pA/AA collisions. A new prescription is proposed for the gain in momentum square, consistent with Krammer process. The model without any free parameter could explain the $E_T$ dependence of $J/\\psi$ over Drell-Yan ratio.

  1. Depression and the Ironic Effects of Thought Suppression: Therapeutic Strategies for ImprovingMental Control

    E-Print Network [OSTI]

    Beevers, Christopher

    are espc- cially likely to engage in thought suppression in an at- tempt to achieve mental control over

  2. Suppression of Rayleigh Taylor instability in strongly coupled plasmas

    SciTech Connect (OSTI)

    Das, Amita; Kaw, Predhiman [Institute for Plasma Research, Bhat, Gandhinagar 382428 (India)

    2014-06-15T23:59:59.000Z

    The Rayleigh Taylor instability in a strongly coupled plasma medium has been investigated using the equations of generalized hydrodynamics. It is demonstrated that the visco-elasticity of the strongly coupled medium due to strong inter particle correlations leads to a suppression of the Rayleigh Taylor instability unless certain threshold conditions are met. The relevance of these results to experiments on laser compression of matter to high densities including those related to inertial confinement fusion using lasers has also been shown.

  3. Suppression of large-scale perturbations by stiff solid

    E-Print Network [OSTI]

    Vladimír Balek; Matej Škovran

    2015-01-28T23:59:59.000Z

    Evolution of large-scale scalar perturbations in the presence of stiff solid (solid with pressure to energy density ratio > 1/3) is studied. If the solid dominated the dynamics of the universe long enough, the perturbations could end up suppressed by as much as several orders of magnitude. To avoid too steep large-angle power spectrum of CMB, radiation must have prevailed over the solid long enough before recombination.

  4. Suppression of large-scale perturbations by stiff solid

    E-Print Network [OSTI]

    Balek, Vladimír

    2015-01-01T23:59:59.000Z

    Evolution of large-scale scalar perturbations in the presence of stiff solid (solid with pressure to energy density ratio > 1/3) is studied. If the solid dominated the dynamics of the universe long enough, the perturbations could end up suppressed by as much as several orders of magnitude. To avoid too steep large-angle power spectrum of CMB, radiation must have prevailed over the solid long enough before recombination.

  5. RHIC and LHC jet suppression in non-central collisions

    E-Print Network [OSTI]

    Magdalena Djordjevic; Marko Djordjevic; Bojana Blagojevic

    2014-06-25T23:59:59.000Z

    Understanding properties of QCD matter created in ultra-relativistic heavy-ion collisions is a major goal of RHIC and LHC experiments. An excellent tool to study these properties is jet suppression of light and heavy flavor observables. Utilizing this tool requires accurate suppression predictions for different experiments, probes and experimental conditions, and their unbiased comparison with experimental data. With this goal, we here extend our dynamical energy loss formalism towards generating predictions for non-central collisions; the formalism takes into account both radiative and collisional energy loss, dynamical (as opposed to static) scattering centers, finite magnetic mass, running coupling and uses no free parameters in comparison with experimental data. Specifically, we here generate predictions for all available centrality ranges, for both LHC and RHIC experiments, and for four different probes (charged hadrons, neutral pions, D mesons and non-prompt $J/\\psi$). We obtain a very good agreement with all available non-central data, and also generate predictions for suppression measurements that will soon become available. Finally, we discuss implications of the obtained good agreement with experimental data with different medium models that are currently considered.

  6. $J/?$ suppression in Pb+Pb collisions, a conventional description

    E-Print Network [OSTI]

    A. K. Chaudhuri

    2001-09-17T23:59:59.000Z

    We have analyzed the latest NA50 data on $J/\\psi$ suppression in Pb + Pb collisions. $J/\\psi$ production is assumed to be a two step process, (i) formation of $c\\bar{c}$ pair, which is accurately calculable in QCD and (ii) formation of $J/\\psi$ meson from the $c\\bar{c}$ pair, which can be conveniently parameterized. In a pA/AA collision, the as the $c\\bar{c}$ pair pass through the nuclear medium, it gain relative square momentum at the rate of $\\epsilon^2$ per unit path length. As a result, some of the $c\\bar{c}$ pairs can gain enough momentum to cross the threshold to become an open charm meson, leading to suppression in pA/AA collisions. The parameters of the model were fixed from experimental data on the total $J/\\psi$ cross section as a function of effective nuclear length. The model without any free parameter, give excellent description of NA50 data on $E_T$ dependence of $J/\\psi$ to Drell-Yan ratio. The model was applied to predict the $E_T$ dependence of $J/\\psi$ at RHIC energy. Much larger suppression of $J/\\psi$, in agreement with other model calculations are predicted.

  7. Rotary rail car dumper coal-dust-suppressant experiment

    SciTech Connect (OSTI)

    Meyer, J.H.; Hereford, L.G.; Lenkevich, M.J.

    1984-10-01T23:59:59.000Z

    A rotary rail car dumper dust-suppressant experiment was performed at the PEPCO Morgantown Power Plant coal handling facility, Newburg, Maryland during the late summer and early fall of 1983. From previous observations of rotary coal car dumping, it was observed that large amounts of dust, especially for washed coal, were generated from the exposed top layer of coal in the open rail car. An overhead spray system using water and surfactant was used to examine the effectiveness of surface wetting just before dumping. High volume sampling at both the entrance and exit doorways of the dumper shed was used to determine the coal dust reduction. A total of 23 tests was performed, of which 16 tests were considered valid. All data were normalized for background, number of tons dumped and sampling time. The use of an overhead spray system can substantially suppress fugitive coal dust generated by rotary rail car dumping of coal. A water and surfactant mixture provided coal-dust-suppressant efficiencies ranging from 47% to 79% with an average of 61% for a combination of washed, mixed, and unwashed coal.

  8. Edinburgh Research Explorer ERK2 Suppresses Self-Renewal Capacity of Embryonic Stem

    E-Print Network [OSTI]

    Koehn, Philipp

    Edinburgh Research Explorer ERK2 Suppresses Self-Renewal Capacity of Embryonic Stem Cells, T 2013, 'ERK2 Suppresses Self-Renewal Capacity of Embryonic Stem Cells, but Is Not Required for Multi date: 26. Jun. 2014 #12;ERK2 Suppresses Self-Renewal Capacity of Embryonic Stem Cells

  9. Efficiency-Droop Suppression by Using Large-Bandgap AlGaInN Thin Barrier

    E-Print Network [OSTI]

    Gilchrist, James F.

    Efficiency-Droop Suppression by Using Large-Bandgap AlGaInN Thin Barrier Layers in InGaN Quantum DOI: 10.1109/JPHOT.2013.2255028 1943-0655/$31.00 Ó2013 IEEE #12;Efficiency-Droop Suppression by Using with the consideration of carrier transport effect for efficiency droop suppression. The lattice-matched Al

  10. Strangeness Suppression of qq? Creation Observed in Exclusive Reactions

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Mestayer, Mac [JLAB; Park, Kijun; Adhikari, Krishna; Aghasyan, Mher; Anefalos Pereira, Sergio; Ball, Jacques; Battaglieri, Marco; Batourine, V; Bedlinskiy, Ivan; Biselli, Angela; Boyarinov, Sergey; Briscoe, William; Brooks, William; Burkert, Volker; Carman, Daniel; Celentano, Andrea; Chandavar, Shloka; Charles, Gabriel; Colaneri, Luca; Cole, Philip; Contalbrigo, Marco; Cortes, Olga; Crede, Volker; D'Angelo, Annalisa; Dashyan, Natalya; De Vita, Raffaella; Deur, Alexandre; Djalali, Chaden; Doughty, David; Dupre, Raphael; El Alaoui, Ahmed; El Fassi, Lamiaa; Elouadrhiri, Latifa; Eugenio, Paul; Fedotov, Gleb; Fleming, Jamie; Forest, Tony; Garillon, Brice; Garcon, Michel; Ghandilyan, Yeranuhi; Gilfoyle, Gerard; Giovanetti, Kevin; Girod-Gard, Francois-Xavier; Goetz, John; Golovach, Evgeny; Gothe, Ralf; Griffioen, Keith; Guegan, Baptiste; Guidal, Michel; Hakobyan, Hayk; Hanretty, Charles; Hattawy, Mohammad; Holtrop, Maurik; Hughes, Simon; Hyde, Charles; Ilieva, Yordanka; Ireland, David; Jiang, Hao; Jo, Hyon-Suk; Joo, Kyungseon; Keller, Dustin; Khandaker, Mahbubul; Kim, Andrey; Kim, Wooyoung; Koirala, Suman; Kubarovsky, Valery; Kuleshov, Sergey; Lenisa, Paolo; Levine, William; Livingston, Ken; Lu, Haiyun; MacGregor, Ian; Mayer, Michael; McKinnon, Bryan; Meyer, Curtis; Mirazita, Marco; Mokeev, Viktor; Montgomery, Rachel; Moody, Cristina; Moutarde, Herve; Movsisyan, Aram; Munoz Camacho, Carlos; Nadel-Turonski, Pawel; Niccolai, Silvia; Niculescu, Gabriel; Niculescu, Maria; Osipenko, Mikhail; Ostrovidov, Alexander; Pappalardo, Luciano; Paremuzyan, Rafayel; Peng, Peng; Phelps, William; Pisano, Silvia; Pogorelko, Oleg; Pozdniakov, Serguei; Price, John; Protopopescu, Dan; Puckett, Andrew; Raue, Brian; Rimal, Dipak; Ripani, Marco; Rizzo, Alessandro; Rosner, Guenther; Roy, Priyashree; Sabatie, Franck; Saini, Mukesh; Schott, Diane; Schumacher, Reinhard; Simonyan, Ani; Sokhan, Daria; Strauch, Steffen; Sytnik, Valeriy; Tang, Wei; Tian, Ye; Ungaro, Maurizio; Vernarsky, Brian; Vlasov, Alexander; Voskanyan, Hakob; Voutier, Eric; Walford, Natalie; Watts, Daniel; Wei, Xiangdong; Weinstein, Lawrence; Wood, Michael; Zachariou, Nicholas; Zhang, Jixie; Zhao, Zhiwen; Zonta, Irene

    2014-10-01T23:59:59.000Z

    We measured the ratios of electroproduction cross sections from a proton target for three exclusive meson-baryon final states: ?K+, p?0, and n?+, with the CLAS detector at Jefferson Lab. Using a simple model of quark hadronization, we extract qq¯ creation probabilities for the first time in exclusive two-body production, in which only a single qq¯ pair is created. We observe a sizable suppression of strange quark-antiquark pairs compared to nonstrange pairs, similar to that seen in high-energy production.

  11. Semiclassical suppression of weak anisotropies of a generic Universe

    E-Print Network [OSTI]

    Marco Valerio Battisti; Riccardo Belvedere; Giovanni Montani

    2009-06-11T23:59:59.000Z

    A semiclassical mechanism which suppresses the weak anisotropies of an inhomogeneous cosmological model is developed. In particular, a wave function of this Universe having a meaningful probabilistic interpretation is obtained that is in agreement with the Copenhagen School. It describes the evolution of the anisotropies with respect to the isotropic scale factor which is regarded as a semiclassical variable playing an observer-like role. Near the cosmological singularity the solution spreads over all values of the anisotropies while, when the Universe expands sufficiently, the closed Friedmann-Robertson-Walker model appears to be the favorite state.

  12. Suppression of Quantum Scattering in Strongly Confined Systems

    SciTech Connect (OSTI)

    Kim, J. I. [Departamento de Pesquisas, Altanova, R. Silva Teles 712, CEP 03026-000, Bras, Sa(tilde sign)o Paulo, SP, Brasil (Brazil); Melezhik, V. S. [Bogoliubov Laboratory of Theoretical Physics, Joint Institute for Nuclear Research, Dubna, Moscow Region 141980 (Russian Federation); Schmelcher, P. [Physikalisches Institut, Universitaet Heidelberg, Philosophenweg 12, 69120 Heidelberg (Germany); Theoretische Chemie, Institut fuer Physikalische Chemie, Universitaet Heidelberg, Im Neuenheimer Feld 229, 69120 Heidelberg (Germany)

    2006-11-10T23:59:59.000Z

    We demonstrate that scattering of particles strongly interacting in three dimensions (3D) can be suppressed at low energies in a quasi-one-dimensional (1D) confinement. The underlying mechanism is the interference of the s- and p-wave scattering contributions with large s- and p-wave 3D scattering lengths being a necessary prerequisite. This low-dimensional quantum scattering effect might be useful in 'interacting' quasi-1D ultracold atomic gases, guided atom interferometry, and impurity scattering in strongly confined quantum wire-based electronic devices.

  13. Suppression and enhancement of transcriptional noise by DNA looping

    E-Print Network [OSTI]

    Jose M. G. Vilar; Leonor Saiz

    2014-06-11T23:59:59.000Z

    DNA looping has been observed to enhance and suppress transcriptional noise but it is uncertain which of these two opposite effects is to be expected for given conditions. Here, we derive analytical expressions for the main quantifiers of transcriptional noise in terms of the molecular parameters and elucidate the role of DNA looping. Our results rationalize paradoxical experimental observations and provide the first quantitative explanation of landmark individual-cell measurements at the single molecule level on the classical lac operon genetic system [Choi et al., Science 322, 442-446 (2008)].

  14. Suppression of energetic particle driven instabilities with HHFW heating

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Fredrickson, E. D.; Taylor, G.; Bertelli, N.; Darrow, D. S.; Gorelenkov, N.; Kramer, G.; Liu, D.; Crocker, N. A.; Kubota, S.; White, R.

    2015-01-01T23:59:59.000Z

    In plasmas in the National Spherical Torus Experiment (NSTX) [Ono et al., Nucl. Fusion 40 (2000) 557] heated with neutral beams, the beam ions typically excite Energetic Particle Modes (EPMs or fishbones), and Toroidal, Global or Compressional Alfvén Eigenmodes (TAE, GAE, CAE). These modes can redistribute the energetic beam ions, altering the beam driven current profile and the plasma heating profile, or they may affect electron thermal transport or cause losses of the beam ions. In this paper we present experimental results where these instabilities, driven by the super-thermal beam ions, are suppressed with the application of High Harmonic Fastmore »Wave heating.« less

  15. Suppression of soft nuclear bremsstrahlung in proton-nucleus collisions

    E-Print Network [OSTI]

    M. J. van Goethem; L. Aphecetche; J. C. S. Bacelar; H. Delagrange; J. Diaz; D. d'Enterria; M. Hoefman; R. Holzmann; H. Huisman; N. Kalantar--Nayestanaki; A. Kugler; H. Loehner; G. Martinez; J. G. Messchendorp; R. W. Ostendorf; S. Schadmand; R. H. Siemssen; R. S. Simon; Y. Schutz; R. Turrisi; M. Volkerts; H. W. Wilschut

    2001-11-30T23:59:59.000Z

    Photon energy spectra up to the kinematic limit have been measured in 190 MeV proton reactions with light and heavy nuclei to investigate the influence of the multiple-scattering process on the photon production. Relative to the predictions of models based on a quasi-free production mechanism a strong suppression of bremsstrahlung is observed in the low-energy region of the photon spectrum. We attribute this effect to the interference of photon amplitudes due to multiple scattering of nucleons in the nuclear medium.

  16. Suppression of energetic particle driven instabilities with HHFW heating

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Fredrickson, E. D. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Taylor, G. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Bertelli, N. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Darrow, D. S. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Gorelenkov, N. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Kramer, G. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Liu, D. [University of California, Irvine, CA (United States); Crocker, N. A. [University of California, Los Angeles (United States); Kubota, S. [University of California, Los Angeles (United States); White, R. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States)

    2015-01-01T23:59:59.000Z

    In plasmas in the National Spherical Torus Experiment (NSTX) [Ono et al., Nucl. Fusion 40 (2000) 557] heated with neutral beams, the beam ions typically excite Energetic Particle Modes (EPMs or fishbones), and Toroidal, Global or Compressional Alfvén Eigenmodes (TAE, GAE, CAE). These modes can redistribute the energetic beam ions, altering the beam driven current profile and the plasma heating profile, or they may affect electron thermal transport or cause losses of the beam ions. In this paper we present experimental results where these instabilities, driven by the super-thermal beam ions, are suppressed with the application of High Harmonic Fast Wave heating.

  17. Hydrodynamical model for $J/?$ suppression and elliptic flow

    E-Print Network [OSTI]

    A. K. Chaudhuri

    2009-10-06T23:59:59.000Z

    In a hydrodynamic model, we have studied $J/\\psi$ suppression and elliptic flow in Au+Au collisions at RHIC energy $\\sqrt{s}$=200 GeV. At the initial time, $J/\\psi$'s are randomly distributed in the fluid. As the fluid evolve in time, the free streaming $J/\\psi$'s are dissolved if the local fluid temperature exceeds a melting temperature $T_{J/\\psi}$. Sequential melting of charmonium states ($\\chi_c$, $\\psi\\prime$ and $J/\\psi$), with melting temperatures $T_{\\chi_c}=T_{\\psi\\prime} \\approx 1.2T_c$, $T_{J/\\psi} \\approx2T_c$ and feed-down fraction $F\\approx 0.3$, is consistent with the PHENIX data on $J/\\psi$ suppression and near zero elliptic flow for $J/\\psi$'s. It is also shown that the model will require substantial regeneration of charmoniums, if the charmonium states dissolve at temperature close to the critical temperature, $T_{\\chi_c}=T_{\\psi\\prime} \\leq T_c$, $T_{J/\\psi}\\approx1.2T_c$. The regenerated charmoniums will have positive elliptic flow.

  18. Nuclear absorption and anomalous $J/?$ suppression in Pb+Pb collisions

    E-Print Network [OSTI]

    A. K. Chaudhuri

    2003-07-31T23:59:59.000Z

    We discuss $J/\\psi$ suppression in a QCD based nuclear absorption model. Centrality dependence of $J/\\psi$ suppression in S+U and in Pb+Pb collisions are explained in the model. However, the model fails to explain the centrality dependence of $\\psi\\prime$ suppression. $\\psi\\prime$ suppression in S+U or in Pb+Pb collisions require additional suppression. Additional suppression of $\\psi\\prime$, due to hadronic comovers or due to QGP formation could not be distinguished in Pb+Pb collisions. We then show that the centrality dependence of the ratio, $\\psi\\prime$ over $J/\\psi$, could possibly distinguish two scenario (e.g. QGP or hadronic comover) at RHIC energy.

  19. acid suppresses uv-b-induced: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topic Index 1 Suppression of rice methane emission by sulfate deposition in simulated acid rain Geosciences Websites Summary: from rice agriculture. Emissions from rice plants...

  20. Study on higher harmonic suppression using edge filter and polished Si wafer

    SciTech Connect (OSTI)

    Gupta, R. K., E-mail: rkg@rrcat.gov.in; Singh, Amol, E-mail: rkg@rrcat.gov.in; Modi, Mohammed H., E-mail: rkg@rrcat.gov.in; Lodha, G. S., E-mail: rkg@rrcat.gov.in [X-ray Optics Section, ISU Division, Raja Ramanna Centre for Advanced Technology, Indore-452013 (India)

    2014-04-24T23:59:59.000Z

    Higher harmonics contamination is a severe problem in synchrotron beamlines where grating monochromators are used. In these beamlines, absorption edge filters and critical angle mirrors are used to suppress the harmonic contaminations. In the present study, carried out using Indus-1 reflectivity beamline, a harmonic suppression characteristic of Al edge filter and polished silicon wafer are determined. It is found that the Al filter suppresses higher harmonics in 2–7% range whereas the polished silicon wafer can suppress the higher harmonics below 1%. The results of comparative study are discussed.

  1. Method and apparatus for suppressing waves in a borehole

    DOE Patents [OSTI]

    West, Phillip B.

    2005-10-04T23:59:59.000Z

    Methods and apparatus for suppression of wave energy within a fluid-filled borehole using a low pressure acoustic barrier. In one embodiment, a flexible diaphragm type device is configured as an open bottomed tubular structure for disposition in a borehole to be filled with a gas to create a barrier to wave energy, including tube waves. In another embodiment, an expandable umbrella type device is used to define a chamber in which a gas is disposed. In yet another embodiment, a reverse acting bladder type device is suspended in the borehole. Due to its reverse acting properties, the bladder expands when internal pressure is reduced, and the reverse acting bladder device extends across the borehole to provide a low pressure wave energy barrier.

  2. Pressure suppression containment system for boiling water reactor

    DOE Patents [OSTI]

    Gluntz, D.M.; Nesbitt, L.B.

    1997-01-21T23:59:59.000Z

    A system is disclosed for suppressing the pressure inside the containment of a BWR following a postulated accident. A piping subsystem is provided which features a main process pipe that communicates the wetwell airspace to a connection point downstream of the guard charcoal bed in an offgas system and upstream of the main bank of delay charcoal beds which give extensive holdup to offgases. The main process pipe is fitted with both inboard and outboard containment isolation valves. Also incorporated in the main process pipe is a low-differential-pressure rupture disk which prevents any gas outflow in this piping whatsoever until or unless rupture occurs by virtue of pressure inside this main process pipe on the wetwell airspace side of the disk exceeding the design opening (rupture) pressure differential. The charcoal holds up the radioactive species in the noncondensable gas from the wetwell plenum by adsorption, allowing time for radioactive decay before the gas is vented to the environs. 3 figs.

  3. Pressure suppression containment system for boiling water reactor

    DOE Patents [OSTI]

    Gluntz, Douglas M. (San Jose, CA); Nesbitt, Loyd B. (San Jose, CA)

    1997-01-01T23:59:59.000Z

    A system for suppressing the pressure inside the containment of a BWR following a postulated accident. A piping subsystem is provided which features a main process pipe that communicates the wetwell airspace to a connection point downstream of the guard charcoal bed in an offgas system and upstream of the main bank of delay charcoal beds which give extensive holdup to offgases. The main process pipe is fitted with both inboard and outboard containment isolation valves. Also incorporated in the main process pipe is a low-differential-pressure rupture disk which prevents any gas outflow in this piping whatsoever until or unless rupture occurs by virtue of pressure inside this main process pipe on the wetwell airspace side of the disk exceeding the design opening (rupture) pressure differential. The charcoal holds up the radioactive species in the noncondensable gas from the wetwell plenum by adsorption, allowing time for radioactive decay before the gas is vented to the environs.

  4. FRACTAL SHAPED MICROSTRIP COUPLED LINE BAND PASS FILTERS FOR SUPPRESSION OF 2ND

    E-Print Network [OSTI]

    Tentzeris, Manos

    1 FRACTAL SHAPED MICROSTRIP COUPLED LINE BAND PASS FILTERS FOR SUPPRESSION OF 2ND HARMONIC Il Kwon Koch fractal curves are proposed for the first time. These filters are fabricated on Liquid Crystal, the 2nd harmonic of fractal filters can be significantly suppressed through the use of fractal shapes

  5. Suppressing Multi-Channel Ultra-Low-Field MRI Measurement Noise Using Data Consistency and Image

    E-Print Network [OSTI]

    Suppressing Multi-Channel Ultra-Low-Field MRI Measurement Noise Using Data Consistency and Image of Mathematics, National Taiwan University, Taipei, Taiwan, 4 Elekta Oy, Helsinki, Finland Abstract Ultra-low. (2013) Suppressing Multi-Channel Ultra-Low-Field MRI Measurement Noise Using Data Consistency and Image

  6. Precipitation suppression by anthropogenic air pollution: major loss of water resources where we need them most

    E-Print Network [OSTI]

    Daniel, Rosenfeld

    Precipitation suppression by anthropogenic air pollution: major loss of water resources where we inferences of air pollution suppressing precipitation lead us to investigate historical climate records precipitation, decreases with time in the polluted regions and remains unchanged where no pollution sources were

  7. Assessment of compost for suppression of Fusarium Patch (Microdochium nivale) and Typhula Blight

    E-Print Network [OSTI]

    Boland, Greg J.

    Assessment of compost for suppression of Fusarium Patch (Microdochium nivale) and Typhula Blight 2001; accepted 21 May 2002 Abstract Two composts were evaluated for suppression of Fusarium Patch of compost applied at either 48.7 or 97:4kg=100m2 reduced snow mold severity to levels not significantly

  8. Suppressive Drug Interactions between Antifungals Marjon G.J. de Vos1 and Tobias Bollenbach1,*

    E-Print Network [OSTI]

    Bulyk, Martha L.

    Suppressive Drug Interactions between Antifungals Marjon G.J. de Vos1 and Tobias Bollenbach1,* 1IST a systematic study of drug interactions be- tween antifungal compounds. Suppressive drug interactions occur. When two drugs are combined, they may interact synergistically or antago- nistically; for synergistic

  9. Kalispel Non-Native Fish Suppression Project 2007 Annual Report.

    SciTech Connect (OSTI)

    Wingert, Michele; Andersen, Todd [Kalispel Natural Resource Department

    2008-11-18T23:59:59.000Z

    Non-native salmonids are impacting native salmonid populations throughout the Pend Oreille Subbasin. Competition, hybridization, and predation by non-native fish have been identified as primary factors in the decline of some native bull trout (Salvelinus confluentus) and westslope cutthroat trout (Oncorhynchus clarki lewisi) populations. In 2007, the Kalispel Natural Resource Department (KNRD) initiated the Kalispel Nonnative Fish Suppression Project. The goal of this project is to implement actions to suppress or eradicate non-native fish in areas where native populations are declining or have been extirpated. These projects have previously been identified as critical to recovering native bull trout and westslope cutthroat trout (WCT). Lower Graham Creek was invaded by non-native rainbow (Oncorhynchus mykiss) and brook trout (Salvelinus fontinalis) after a small dam failed in 1991. By 2003, no genetically pure WCT remained in the lower 700 m of Graham Creek. Further invasion upstream is currently precluded by a relatively short section of steep, cascade-pool stepped channel section that will likely be breached in the near future. In 2008, a fish management structure (barrier) was constructed at the mouth of Graham Creek to preclude further invasion of non-native fish into Graham Creek. The construction of the barrier was preceded by intensive electrofishing in the lower 700 m to remove and relocate all captured fish. Westslope cutthroat trout have recently been extirpated in Cee Cee Ah Creek due to displacement by brook trout. We propose treating Cee Cee Ah Creek with a piscicide to eradicate brook trout. Once eradication is complete, cutthroat trout will be translocated from nearby watersheds. In 2004, the Washington Department of Fish and Wildlife (WDFW) proposed an antimycin treatment within the subbasin; the project encountered significant public opposition and was eventually abandoned. However, over the course of planning this 2004 project, little public involvement or education was conducted prior to the planned implementation. Therefore, in 2007 we implemented an extensive process to provide public education, address public concerns and provide opportunity for public involvement in implementing piscicides and other native fish recovery actions in the subbasin.

  10. Quadrature mixture LO suppression via DSW DAC noise dither

    DOE Patents [OSTI]

    Dubbert, Dale F. (Cedar Crest, NM); Dudley, Peter A. (Albuquerque, NM)

    2007-08-21T23:59:59.000Z

    A Quadrature Error Corrected Digital Waveform Synthesizer (QECDWS) employs frequency dependent phase error corrections to, in effect, pre-distort the phase characteristic of the chirp to compensate for the frequency dependent phase nonlinearity of the RF and microwave subsystem. In addition, the QECDWS can employ frequency dependent correction vectors to the quadrature amplitude and phase of the synthesized output. The quadrature corrections cancel the radars' quadrature upconverter (mixer) errors to null the unwanted spectral image. A result is the direct generation of an RF waveform, which has a theoretical chirp bandwidth equal to the QECDWS clock frequency (1 to 1.2 GHz) with the high Spurious Free Dynamic Range (SFDR) necessary for high dynamic range radar systems such as SAR. To correct for the problematic upconverter local oscillator (LO) leakage, precision DC offsets can be applied over the chirped pulse using a pseudo-random noise dither. The present dither technique can effectively produce a quadrature DC bias which has the precision required to adequately suppress the LO leakage. A calibration technique can be employed to calculate both the quadrature correction vectors and the LO-nulling DC offsets using the radar built-in test capability.

  11. Transverse energy dependence of J/Psi suppression in Au+Au collisions at RHIC energy

    E-Print Network [OSTI]

    A. K. Chaudhuri

    2001-12-18T23:59:59.000Z

    Prediction for transverse energy dependence of $J/\\psi$ to Drell-Yan ratio in Au+Au collisions at RHIC energy was obtained in a model which assume 100% absorption of $J/\\psi$ above a threshold density. The threshold density was obtained by fitting the NA50 data on $J/\\psi$ suppression in Pb+Pb collisions at SPS energy. At RHIC energy, hard processes may be important. Prediction of $J/\\psi$ suppression with and without hard processes were obtained. With hard processes included, $J/\\psi$'s are strongly suppressed.

  12. Compost: A study of the development process and end-product potential for suppression of turfgrass disease

    E-Print Network [OSTI]

    Boland, Greg J.

    Review Compost: A study of the development process and end-product potential for suppression, biological control, compost, disease, fungi, microbiology, pathogen, suppression, turf, turfgrass Summary The relationships among the chemical, physical and biological aspects of compost and their role in suppression

  13. The role of E2F4 in the growth suppressive properties of the retinoblastoma protein

    E-Print Network [OSTI]

    Lee, Eunice Y. (Eunice Yoon)

    2005-01-01T23:59:59.000Z

    The growth suppressive functions of the retinoblastoma protein (pRB), the first identified tumor suppressor, are considerably mediated through the repression of the E2F transcription factors. Functional inactivation of ...

  14. Feedback schemes for radiation damping suppression in NMR: a control-theoretical perspective

    E-Print Network [OSTI]

    Altafini, C.

    In NMR spectroscopy, the collective measurement is weakly invasive and its back-action is called radiation damping. The aim of this paper is to provide a control-theoretical analysis of the problem of suppressing this ...

  15. Feedback and its Feedback Effect on Feedback: Photoionization Suppression and its Impact on Galactic Outflows

    E-Print Network [OSTI]

    Matthew M. Pieri; Hugo Martel

    2007-05-02T23:59:59.000Z

    We show that radiative feedback due to reionization has a pronounced effect on the extent of mechanical feedback due to galactic outflows. The photoionization of the Intergalactic Medium (IGM) suppresses low-mass galaxy formation by photoheating the gas and limiting atomic line cooling. The number of low-mass galaxies is central for the enrichment of the IGM as these objects have the capacity to enrich a significant fraction (by volume) of the Universe. We use a modified version of our galactic outflow model, combined with a simple criterion for suppression, to investigate the potential impact upon the IGM. We find that this suppression strongly reduces the enrichment of the IGM and is sensitive to the reionization history. We also investigate the contribution of halos of different masses with varying degrees of suppression.

  16. Beam dynamics and wakefield suppression in interleaved damped and detuned structures for CLIC

    E-Print Network [OSTI]

    D'Elia, A; Khan, V F; Jones, R M; Latina, A; Nesmiyan, I; Riddone, G

    2013-01-01T23:59:59.000Z

    Acceleration of multiple bunches of charged particles in the main linacs of the Compact Linear Collider (CLIC) with high accelerating fields provides two major challenges: firstly, to ensure the surface electromagnetic fields do not cause electrical breakdown and subsequent surface damage, and secondly, to ensure the beam-excited wakefields are sufficiently suppressed to avoid appreciable emittance dilution. In the baseline design for CLIC, heavy wakefield suppression is used (Q ~ 10) [1] and this ensures the beam quality is well-preserved [2]. Here we discuss an alternative means to suppress the wakefield which relies on strong detuning of the cell dipole frequencies, together with moderate damping, effected by manifolds which are slot-coupled to each accelerating cell. This damped and detuned wakefield suppression scheme is based on the methodology developed for the Japanese Linear Collider/Next Linear Collider (JLC/NLC) [3]. Here we track the multi-bunch beam down the complete collider, u...

  17. Vibration suppression of laminated composite plates using embedded smart material layers

    E-Print Network [OSTI]

    Krishnan, Sivasubramaniam

    2000-01-01T23:59:59.000Z

    In this study, a complete theoretical formulation of laminated composite plates with integrated smart material layers that serve as sensors and/or actuators is presented for the vibration suppression of laminated composite plates. The third...

  18. Microbial studies of compost: bacterial identification, and their potential for turfgrass pathogen suppression

    E-Print Network [OSTI]

    Boland, Greg J.

    Microbial studies of compost: bacterial identification, and their potential for turfgrass pathogen; accepted 17 April 2002 Keywords: Bacteria, compost, biocontrol disease suppression, grey snow mould Composting is the degradation of organic materials through the activities of diverse microorganisms

  19. Wideband phased array antennas and compact, harmonic-suppressed microstrip filters 

    E-Print Network [OSTI]

    Tu, Wen-Hua

    2009-05-15T23:59:59.000Z

    . Since the electromagnetic spectrum is limited and has to be shared, interference is getting serious as more and more wireless applications emerge. Filters are key components to prevent harmonic interference. The harmonic signals can be suppressed...

  20. Wideband phased array antennas and compact, harmonic-suppressed microstrip filters

    E-Print Network [OSTI]

    Tu, Wen-Hua

    2009-05-15T23:59:59.000Z

    . Since the electromagnetic spectrum is limited and has to be shared, interference is getting serious as more and more wireless applications emerge. Filters are key components to prevent harmonic interference. The harmonic signals can be suppressed...

  1. Gain media edge treatment to suppress amplified spontaneous emission in a high power laser

    DOE Patents [OSTI]

    Hackel, Lloyd A. (Livermore, CA); Soules, Thomas F. (Livermore, CA); Fochs, Scott N. (Livermore, CA); Rotter, Mark D. (San Ramon, CA); Letts, Stephan A. (San Ramon, CA)

    2011-02-22T23:59:59.000Z

    A novel method and apparatus for suppressing ASE and/or parasitic oscillation modes in a laser is introduced. By roughening one or more peripheral edges of a solid-state crystal or ceramic laser gain media and by bonding such edges to a predetermined electromagnetic absorbing material arranged adjacent to the entire outer surface of the peripheral edges of the roughened laser gain media, ASE, parasitic oscillation modes and/or residual pump energy can be effectively suppressed.

  2. Gain media edge treatment to suppress amplified spontaneous emission in a high power laser

    DOE Patents [OSTI]

    Hackel, Lloyd A. (Livermore, CA); Soules, Thomas F. (Livermore, CA); Fochs, Scott N. (Livermore, CA); Rotter, Mark D. (San Ramon, CA); Letts, Stephan A. (San Ramon, CA)

    2008-12-09T23:59:59.000Z

    A novel method and apparatus for suppressing ASE and parasitic oscillation modes in a high average power laser is introduced. By roughening one or more peripheral edges of a solid-state crystal or ceramic laser gain media and by bonding such edges using a substantially high index bonding elastomer or epoxy to a predetermined electromagnetic absorbing arranged adjacent to the entire outer surface of the peripheral edges of the roughened laser gain media, ASE and parasitic oscillation modes can be effectively suppressed.

  3. $J/?$ suppression in the threshold model at RHIC and LHC energy

    E-Print Network [OSTI]

    A. K. Chaudhuri

    2007-11-14T23:59:59.000Z

    In the QGP based threshold model \\cite{Blaizot:2000ev,Blaizot:1996nq}, in addition to the normal nuclear absorption, $J/\\psi$'s are subjected to an 'anomalous' suppression such that above a threshold density $n_{J/\\psi}$, all the $J/\\psi$'s are melted. In the threshold model we have analysed the recent PHENIX data on the centrality dependence of $J/\\psi$ suppression in Au+Au collisions at RHIC. Feedback from decay of the state $\\chi$ is accounted for. $J/\\psi$'s are anomalously suppressed above a threshold density, $n_{J/\\psi}=3.57\\pm 0.17$ $fm^{-2}$. Threshold density for anomalous suppression of the state $\\chi$ is uncertain to a large extent, $n_\\chi=0.32 \\pm 0.32$ $fm^{-2}$. The fraction $F$ of the state $\\chi$ can not be determined unambiguously, depending on the nuclear absorption, it can vary from 20% to 40%. We have also predicted for the suppression in Pb+Pb collisions at LHC energy. In central Pb+Pb collisions, $J/\\psi$'s are suppressed by a factor of 3-4. Suppression pattern is rather similar to that in Au+Au collisions, if not slighty less in central collisions. Using the PHENIX data on the participant number dependence of the Bjorken energy density, we have also estimated the QGP formation time. For critical temperature $T_c$=192 MeV, estimated QGP formation time ranges between 0.07-0.09 fm/c.

  4. GNOSIS: THE FIRST INSTRUMENT TO USE FIBER BRAGG GRATINGS FOR OH SUPPRESSION

    SciTech Connect (OSTI)

    Trinh, Christopher Q.; Ellis, Simon C.; Bland-Hawthorn, Joss; Bryant, Julia; O'Byrne, John [Sydney Institute for Astronomy, School of Physics, The University of Sydney, NSW 2006 (Australia); Lawrence, Jon S.; Horton, Anthony J.; Shortridge, Keith; Case, Scott; Colless, Matthew; Gers, Luke; Lee, Steve; Miziarski, Stan [Australian Astronomical Observatory, 105 Delhi Road, North Ryde, P.O. Box 915, NSW 1670 (Australia); Leon-Saval, Sergio G. [Institute of Photonics and Optical Science, School of Physics, University of Sydney, NSW 2006 (Australia); Couch, Warrick; Glazebrook, Karl [Centre for Astrophysics and Supercomputing, Swinburne University of Technology, P.O. Box 218, Hawthorn, VIC 3122 (Australia); Freeman, Kenneth [Research School of Astronomy and Astrophysics, Australian National University, Weston Creek, ACT 2611 (Australia); Loehmannsroeben, Hans-Gerd [innoFSPEC-Institut fuer Chemie/Physikalische Chemie, Universitaet Potsdam, Karl-Liebknecht-Strasse 24-25, D-14476 Potsdam-Golm (Germany); Haynes, Roger; Roth, Martin M., E-mail: c.trinh@physics.usyd.edu.au [innoFSPEC-Leibniz-Institut fuer Astrophysik Potsdam, An der Sternwarte 16, D-14482 Potsdam (Germany); and others

    2013-02-01T23:59:59.000Z

    The near-infrared is an important part of the spectrum in astronomy, especially in cosmology because the light from objects in the early universe is redshifted to these wavelengths. However, deep near-infrared observations are extremely difficult to make from ground-based telescopes due to the bright background from the atmosphere. Nearly all of this background comes from the bright and narrow emission lines of atmospheric hydroxyl (OH) molecules. The atmospheric background cannot be easily removed from data because the brightness fluctuates unpredictably on short timescales. The sensitivity of ground-based optical astronomy far exceeds that of near-infrared astronomy because of this long-standing problem. GNOSIS is a prototype astrophotonic instrument that utilizes 'OH suppression fibers' consisting of fiber Bragg gratings and photonic lanterns to suppress the 103 brightest atmospheric emission doublets between 1.47 and 1.7 {mu}m. GNOSIS was commissioned at the 3.9 m Anglo-Australian Telescope with the IRIS2 spectrograph to demonstrate the potential of OH suppression fibers, but may be potentially used with any telescope and spectrograph combination. Unlike previous atmospheric suppression techniques GNOSIS suppresses the lines before dispersion and in a manner that depends purely on wavelength. We present the instrument design and report the results of laboratory and on-sky tests from commissioning. While these tests demonstrated high throughput ( Almost-Equal-To 60%) and excellent suppression of the skylines by the OH suppression fibers, surprisingly GNOSIS produced no significant reduction in the interline background and the sensitivity of GNOSIS+IRIS2 is about the same as IRIS2. It is unclear whether the lack of reduction in the interline background is due to physical sources or systematic errors as the observations are detector noise dominated. OH suppression fibers could potentially impact ground-based astronomy at the level of adaptive optics or greater. However, until a clear reduction in the interline background and the corresponding increasing in sensitivity is demonstrated optimized OH suppression fibers paired with a fiber-fed spectrograph will at least provide a real benefit at low resolving powers.

  5. Effect of Island Overlap on ELM Suppression by Resonant Magnetic Perturbations in DIII-D

    SciTech Connect (OSTI)

    Fenstermacher, M E; Evans, T E; Osborne, T H; Schaffer, M J; Aldan, M P; deGrassie, J S; Gohil, P; Joseph, I; Moyer, R A; Snyder, P B; Groebner, R J; Jakubowski, M; Leonard, A W; Schmitz, O

    2007-11-08T23:59:59.000Z

    Recent DIII-D [J.L. Luxon, et al., Nucl. Fusion 43, 1813 (2003)] experiments show a correlation between the extent of overlap of magnetic islands induced in the edge plasma by perturbation coils and complete suppression of Type-I edge localized modes (ELMs) in plasmas with ITER-like electron pedestal collisionality {nu}*{sub e} {approx} 0.1, flux surface shape and low edge safety factor (q{sub 95} {approx} 3.6). With fixed n = 3 resonant magnetic perturbation (RMP) strength, ELM suppression is obtained only in a finite window in the edge safety factor (q{sub 95}) consistent with maximizing the resonant component of the applied helical field. ELM suppression is obtained over an increasing range of q{sub 95} by either increasing the n = 3 RMP strength, or by adding n = 1 perturbations to 'fill in' gaps between islands across the edge plasma. The suppression of Type-I ELMs correlates with a minimum width of the edge region having magnetic islands with Chirikov parameter >1.0, based on vacuum calculations of RMP mode components excluding the plasma response or rotational shielding. The fraction of vacuum magnetic field lines that are lost from the plasma, with connection length to the divertor targets comparable to an electron-ion collisional mean free path, increases throughout the island overlap region in the ELM suppressed case compared with the ELMing case.

  6. Baseline Suppression of Vehicle Portal Monitor Gamma Count Profiles: A Characterization Study

    SciTech Connect (OSTI)

    Lopresti, Charles A.; Weier, Dennis R.; Kouzes, Richard T.; Schweppe, John E.

    2006-06-15T23:59:59.000Z

    Radiation portal monitor (RPM) systems based upon polyvinyl toluene scintillator (PVT) gamma ray detectors have been deployed to detect illicit trafficking in radioactive materials at border crossings. This report sets forth a characterization of the baseline suppression effect in gross-count gamma ray profiles due to shadow shielding by vehicles entering radiation portal monitors. Shadow shielding is of interest because it reduces the alarm sensitivity of portal monitors. This observational study investigated three types of PVT based commercial RPM systems currently deployed at selected ports of entry in terms of spatial effects relative to detector panel orientation - driver versus passenger side, top versus bottom, and narrow lanes versus wide lanes - as observed for a large number of vehicles. Each portal site appears to have a distinctive baseline suppression signature, based on percent maximum suppression relative to measured background. Results suggest that alarm algorithms based on gross-counts may be further refined through attention to individual site characteristics. In addition, longer vehicle transit times were often correlated with stronger baseline suppression, suggesting that baseline suppression studies should take into account duration (length) of transit. (PIET-43741-TM-333-NIM)

  7. Feedback suppression of rotating external kink instabilities in the presence of noise

    SciTech Connect (OSTI)

    Hanson, Jeremy M.; De Bono, Bryan; James, Royce W.; Levesque, Jeffrey P.; Mauel, Michael E.; Maurer, David A.; Navratil, Gerald A.; Pedersen, Thomas Sunn; Shiraki, Daisuke [Applied Physics and Applied Mathematics, Columbia University, 200 S. W. Mudd Building - MC 4701, 500 W. 120th Street, New York, New York 10027 (United States)

    2008-08-15T23:59:59.000Z

    The authors report on the first experimental demonstration of active feedback suppression of rotating external kink modes near the ideal wall limit in a tokamak using Kalman filtering to discriminate the n=1 kink mode from background noise. The Kalman filter contains an internal model that captures the dynamics of a rotating, growing n=1 mode. Suppression of the external kink mode is demonstrated over a broad range of phase angles between the sensed mode and applied control field, and performance is robust at noise levels that render proportional gain feedback ineffective. Suppression of the kink mode is accomplished without excitation of higher frequencies as was observed in previous experiments using lead-lag loop compensation [A. J. Klein et al., Phys Plasmas 12, 040703 (2005)].

  8. Parametric Instability in Long Optical Cavities and Suppression by Dynamic Transverse Mode Frequency Modulation

    E-Print Network [OSTI]

    Zhao, Chunnong; Fang, Qi; Blair, Carl; Qin, Jiayi; Blair, David; Degallaix, Jerome; Yamamoto, Hiroaki

    2015-01-01T23:59:59.000Z

    Three mode parametric instability has been predicted in Advanced gravitational wave detectors. Here we present the first observation of this phenomenon in a large scale suspended optical cavity designed to be comparable to those of advanced gravitational wave detectors. Our results show that previous modelling assumptions that transverse optical modes are stable in frequency except for frequency drifts on a thermal deformation time scale is unlikely to be valid for suspended mass optical cavities. We demonstrate that mirror figure errors cause a dependence of transverse mode offset frequency on spot position. Combined with low frequency residual motion of suspended mirrors, this leads to transverse mode frequency modulation which suppresses the effective parametric gain. We show that this gain suppression mechanism can be enhanced by laser spot dithering or fast thermal modulation. Using Advanced LIGO test mass data and thermal modelling we show that gain suppression factors of 10-20 could be achieved for ind...

  9. Can $J/?$ suppression and $p_T$ broadening signal the deconfinement transition at RHIC?

    E-Print Network [OSTI]

    A. K. Chaudhuri

    2005-06-24T23:59:59.000Z

    We have analyzed the latest NA50 data on $J/\\psi$ suppression in Pb+Pb collisions at CERN SPS. It is shown that a QCD based nuclear absorption model, where $J/\\psi$'s are absorbed in nuclear medium could explain the latest NA50 data on the centrality dependence of the $J/\\psi$ over Drell-Yan ratio. The model also explains the NA50 data on $J/\\psi$ over minimum bias ratio and the $p_T$ broadening of $J/\\psi$'s. A QGP based threshold model where all the $J/\\psi$'s are suppressed above a threshold density, also explains the data sets with smeared threshold density. Even at RHIC energy, centrality dependence of $J/\\psi$ suppression or $p_T$ broadening could not distinguish between the two models.

  10. $J/?$ suppression in Pb+Pb collisions and $p_T$ broadening

    E-Print Network [OSTI]

    A. K. Chaudhuri

    2003-04-10T23:59:59.000Z

    We have analysed the NA50 data, on the centrality dependence of $p_T$ broadening of $J/\\psi$'s, in Pb+Pb collisions, at the CERN-SPS. The data were analysed in a QCD based model, where $J/\\psi$'s are suppressed in 'nuclear' medium. Without any free parameter, the model could explain the NA50 $p_T$ broadening data. The data were also analysed in a QGP based threshold model, where $J/\\psi$ suppression is 100% above a critical density. The QGP based model could not explain the NA50 $p_T$ broadening data. We have also predicted the centrality dependence of $J/\\psi$ suppression and $p_T$ broadening at RHIC energy. Both the models, the QGP based threshold model and the QCD based nuclear absorption model, predict $p_T$ broadening very close to each other.

  11. Measurement of Lambda(C) Branching Fractions of Cabibbo-Suppressed Decay Modes in the BABAR Experiment

    SciTech Connect (OSTI)

    Saleem, Muhammad; /SUNY, Albany

    2006-01-05T23:59:59.000Z

    This dissertation reports on a study of the relative branching fraction measurement of the charmed baryon {Lambda}{sub c} decaying to the Cabibbo-suppressed modes.

  12. Suppression of static electrification of insulating oil for large power transformers

    SciTech Connect (OSTI)

    Yasuda, M.; Goto, K.; Ishii, T.; Masunaga, M.; Mori, E.; Okubo, H.

    1982-11-01T23:59:59.000Z

    Streaming electrification of large power transformers is discussed here from the standpoint of characteristics of insulating oils used in them. First, the relation between the thermal degradation and charging tendency of insulating oils is defined to show that suppressing the degradation of oils to be caused by long term operation of the transformers can minimize the rise in charging tendency, leading to suppressed streaming electrification within the transformer. Second, experimental results show that alkylbenzene mixture oil and benzotriazol additive oil are excellent in charging characteristics when used as insulating oils of large power transformers.

  13. Suppression of Longitudinal Coupled-Bunch Instabilities at the KEK-PF

    SciTech Connect (OSTI)

    Obina, T.; Tobiyama, M.; Honda, T.; Tadano, M.; Flanagan, J.W.; Mitsuhashi, T.; /KEK, Tsukuba; Cheng, W.X.; Fox, J.D.; /SLAC; Teytelman, D.; /Dimtel, Redwood City

    2012-04-09T23:59:59.000Z

    A bunch-by-bunch feedback system has been developed to suppress longitudinal coupled-bunch instabilities at the KEK-PF. A longitudinal kicker based on a DAFNE-type overdamped cavity has been designed and installed in the ring, and a general purpose signal processor, called iGp, has been developed by the collaboration of the KEK, SLAC, and INFN-LNF. The entire feedback loop has been closed by the end of June 2007, and the feedback system has successfully suppressed the longitudinal dipole-mode instabilities up to 430 mA.

  14. Harmonics suppression effect of the quasi-periodic undulator in SASE free-electron-laser

    E-Print Network [OSTI]

    Ai-Lin Wu; Qi-Ka Jia; He-Ting Li

    2013-05-03T23:59:59.000Z

    In this paper, the harmonics suppression effect of QPUs in SASE FEL is investigated. The numerical results show that the harmonics power is reduced by using QPUs, but the fundamental radiation power also has a pronounced decrease as the saturation length gets very long. The cases of employing QPUs as parts of undulators are studied. The calculations show that if the fraction of QPUs and their offgap are appropriate in an undulator system, the harmonics radiation could be suppressed remarkably, meanwhile the fundamental saturation length does not increase too much.

  15. Longitudinal pulse shaping for the suppression of coherent synchrotron radiation-induced emittance growth

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Mitchell, Chad; Qiang, Ji; Emma, Paul

    2013-06-01T23:59:59.000Z

    The damaging effect of coherent synchrotron radiation (CSR) on the emittance and energy spread of high-energy beams in accelerator light sources can significantly constrain the machine design and performance. We propose a mitigation approach in which the dynamical effect of the longitudinal component of CSR is suppressed by appropriately preparing the initial longitudinal current profile of the beam. In a chicane, a linear theory for the mechanism of CSR-induced emittance growth is used to demonstrate how this procedure can produce a beam whose core experiences suppressed transverse emittance growth. The dynamics of such a beam is illustrated for the Berlin-Zeuthen CSR benchmark chicane.

  16. Suppression of Eddy Diffusivity across Jets in the Southern Ocean RAFFAELE FERRARI AND MAXIM NIKURASHIN

    E-Print Network [OSTI]

    Ferrari, Raffaele

    of the Antarctic Circumpolar Current, despite enhanced values of eddy kinetic energy. The expression in the core of the Antarctic Circumpolar Current or on its flanks. A simple expression is derived statistics. This novel expression predicts suppression of the cross-jet eddy diffusivity in the core

  17. Metal-Exchanged Clay and Zeolite Additives as Smoke Suppressants and Fire Retardants for

    E-Print Network [OSTI]

    Pike, Robert D.

    Metal-Exchanged Clay and Zeolite Additives as Smoke Suppressants and Fire Retardants for Poly studies showed that various metal- exchanged clays and zeolites containing only 3­4% of Cu(II), Cu(I), Zn blends of the clays, and the effectiveness of the additives was usually improved considerably by heat

  18. Dynamical epidemic suppression using stochastic prediction and control Ira B. Schwartz

    E-Print Network [OSTI]

    Billings, Lora

    of stochastic dynamical sys- tems [13].) Other methods pulse the population without sam- pling for predictionDynamical epidemic suppression using stochastic prediction and control Ira B. Schwartz Plasma of stochastic processes with underlying deterministic structure. DOI: 10.1103/PhysRevE.70.046220 PACS number

  19. Noise suppression and enhanced focusability in plasma Raman amplifier with multi-frequency pump

    E-Print Network [OSTI]

    Noise suppression and enhanced focusability in plasma Raman amplifier with multi-frequency pump A. Fisch Princeton Plasma Physics Laboratory, Princeton, New Jersey 08543 and Department of Astrophysical Laser pulse compression­amplification through Raman backscattering in plasmas can be facilitated

  20. Prolonged suppression of ecosystem carbon dioxide uptake after an anomalously warm year

    E-Print Network [OSTI]

    Cai, Long

    LETTERS Prolonged suppression of ecosystem carbon dioxide uptake after an anomalously warm year , Yiqi Luo5 & David S. Schimel6 Terrestrial ecosystems control carbon dioxide fluxes to and from and heterotrophic respira- tion, that determines whether an ecosystem is sequestering carbon or releasing

  1. Bisphosphonates suppress periosteal osteoblast activity independently of resorption in rat femur and tibia

    E-Print Network [OSTI]

    Boyer, Edmond

    Recent studies demonstrate that bisphosphonates suppress bone resorption by leading to apoptosis of the osteoclast and inhibiting the differentiation to mature osteoclasts. The influence of bisphosphonates on bone and stimulate osteoblast proliferation and differentiation in vitro, leading to increased bone formation

  2. Electronpolar optical phonon scattering suppression and mobility enhancement in wurtzite heterostructures

    E-Print Network [OSTI]

    Electron­polar optical phonon scattering suppression and mobility enhancement in wurtzite@ee.ucr.edu Abstract. We have shown theoretically that the electron mobility in wurtzite AlN/GaN/AlN heterostructures that the electron mobility can be enhanced in heterostructures made of wurtzite AlGaN/GaN/AlGaN semiconductors via

  3. Method for Suppression of Stacking Faults in Wurtzite III-V Nanowires

    E-Print Network [OSTI]

    Heiblum, Mordehai "Moty"

    Method for Suppression of Stacking Faults in Wurtzite III-V Nanowires Hadas Shtrikman,*, Ronit, 2008; Revised Manuscript Received January 13, 2009 ABSTRACT The growth of wurtzite GaAs and In wurtzite structure and are observed to thicken (via lateral growth) once the axial growth exceeds a certain

  4. Suppressed gross erosion of high-temperature lithium films under high-flux deuterium bombardment

    E-Print Network [OSTI]

    Princeton Plasma Physics Laboratory

    P1-030 Suppressed gross erosion of high-temperature lithium films under high-flux deuterium) and thick (~500 m) lithium films under high-flux deuterium and neon plasma bombardment were studied. For Ne plasmas, Li erosion rates inferred from measurements of Li-I radiation are consistent

  5. Time series study of urban rainfall suppression during clean-up periods

    E-Print Network [OSTI]

    Geng, Jun

    2008-10-10T23:59:59.000Z

    . Effects of Pollutant Aerosols on Precipitation……………….... 3 3. Our Focus………………………………………………………. 6 II STUDY OF SUPPRESSION OF PRECIPITATION IN AIR POLLUTIONS BY ANALYZING DATA FROM...)......................................................................................... 21 6 Trends of ratio of annual precipitation amount of Culver City (CC) and Pasadena (PA)...................................................................................... 23 7 The relationship between precipitation and TSP...

  6. Time series study of urban rainfall suppression during clean-up periods

    E-Print Network [OSTI]

    Geng, Jun

    2009-05-15T23:59:59.000Z

    . Effects of Pollutant Aerosols on Precipitation??????.... 3 3. Our Focus?????????????????????. 6 II STUDY OF SUPPRESSION OF PRECIPITATION IN AIR POLLUTIONS BY ANALYZING DATA FROM...)......................................................................................... 21 6 Trends of ratio of annual precipitation amount of Culver City (CC) and Pasadena (PA)...................................................................................... 23 7 The relationship between precipitation and TSP...

  7. Sensor-less Vibration Suppression and Scan Compensation for Piezoelectric Tube Nanopositioners

    E-Print Network [OSTI]

    Fleming, Andrew J.

    ) (b) Fig. 2. (a) Charge driven tube scanner. (b) Voltage equivalent circuit. introduces two simple nonSensor-less Vibration Suppression and Scan Compensation for Piezoelectric Tube Nanopositioners-fabrication. Much research has proceeded with the aim of reducing hysteresis and vibration, the foremost problems

  8. Progress in year 2010 1. Suppression of Density Fluctuations in a Quantum Degenerate Fermi

    E-Print Network [OSTI]

    Progress in year 2010 1. Suppression of Density Fluctuations in a Quantum Degenerate Fermi Gas with temperatures obtained by fitting the shape of the expanded cloud. 2. Spin gradient demagnetization cooling of ultracold atoms. We have demonstrated a new cooling method in which a time-varying magnetic field gradient

  9. Paclitaxel coating of the luminal surface of hemodialysis grafts with effective suppression of

    E-Print Network [OSTI]

    Park, Jong-Sang

    Paclitaxel coating of the luminal surface of hemodialysis grafts with effective suppression, we developed a method to coat the drug only on the luminal surface of the graft, with little loading only on the luminal surface of the graft without changing the physical properties. To determine its

  10. Fine-Scale Zonal Flow Suppression of Electron Temperature Gradient Turbulence

    E-Print Network [OSTI]

    Lin, Zhihong

    as an explanation for the long time build up of the zonal flow in ETG turbulence and it is shown that the generationFine-Scale Zonal Flow Suppression of Electron Temperature Gradient Turbulence S.E. Parker , J continue to grow algebraically (proportional to time). These fine-scale zonal flows have a radial wave

  11. Is it possible to observe a suppressing of $?$-decay caused by an atomic substance - plasma transition ?

    E-Print Network [OSTI]

    B. V. Vasiliev

    2006-04-24T23:59:59.000Z

    It is supposed that $\\beta$-decay can be slightly suppressed at an atomic substance - plasma transition under a plasma electron gas action. The estimation shows that this effect can give a relative difference of the decay amount on a level of $10^{-4}$.

  12. Br J Nutr . Author manuscript Calcium carbonate suppresses haem toxicity markers without calcium

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Br J Nutr . Author manuscript Page /1 9 Calcium carbonate suppresses haem toxicity markers without-term studies in rats identified calcium carbonate as the most effective calcium salt to bind haem in vitro demonstrated that a diet containing 100 mol/g calcium carbonate did not promote aberrant crypt foci

  13. Suppressed Superconductivity on the Surface of Superconducting RF Quality Niobium for

    E-Print Network [OSTI]

    Suppressed Superconductivity on the Surface of Superconducting RF Quality Niobium for Particle 32310, USA Abstract. Significant performance degradation of superconducting RF (radio frequency) niobium superconductivity at chemically treated RF-quality niobium. We found that pinning of vortices along GBs is weaker

  14. Suppression of 2 phase-slip due to hidden zero modes in one dimensional topological superconductors

    E-Print Network [OSTI]

    Yanikoglu, Berrin

    Suppression of 2 phase-slip due to hidden zero modes in one dimensional topological superconductors-dimensional topological superconducting wires. These wires have been proposed as building blocks for topologically in decoherence. Phase slips in topological superconductors are peculiar for the reason that they occur

  15. Importance of different energy loss effects in jet suppression at RHIC and LHC

    E-Print Network [OSTI]

    Bojana Blagojevic; Magdalena Djordjevic

    2015-05-04T23:59:59.000Z

    Jet suppression is considered to be an excellent probe of QCD matter created in ultra-relativistic heavy ion collisions. Our theoretical predictions of jet suppression, which are based on our recently developed dynamical energy loss formalism, show a robust agreement with various experimental data, which spans across different probes, experiments (RHIC and LHC) and experimental conditions (i.e. all available centrality regions). This formalism includes several key ingredients, such as inclusion of dynamical scattering centers, finite size QCD medium, collisional energy loss, finite magnetic mass and running coupling. While these effects have to be included based on theoretical grounds, it is currently unclear what is their individual importance in accurately interpreting the experimental data, in particular because other approaches to suppression predictions commonly neglect some - or all - of these effects. To address this question, we here study the relative importance of these effects in obtaining accurate suppression predictions for D mesons (clear energy loss probe) at top RHIC and LHC energies. We obtain that several different ingredients are responsible for the accurate predictions, i.e. the robust agreement with the data is a cumulative effect of all the ingredients, though inclusion of the dynamical scattering centers has the largest relative importance.

  16. Optimal noise suppression in Fresnel incoherent correlation holography (FINCH) configured for

    E-Print Network [OSTI]

    Rosen, Joseph

    Optimal noise suppression in Fresnel incoherent correlation holography (FINCH) configured 131543); published 14 October 2010 An optimal setup in the sense of imaging resolution for the Fresnel of America OCIS codes: 090.1995, 030.6140, 110.4280. 1. Introduction Fresnel incoherent correlation

  17. Time series study of urban rainfall suppression during clean-up periods 

    E-Print Network [OSTI]

    Geng, Jun

    2009-05-15T23:59:59.000Z

    . Effects of Pollutant Aerosols on Precipitation??????.... 3 3. Our Focus?????????????????????. 6 II STUDY OF SUPPRESSION OF PRECIPITATION IN AIR POLLUTIONS BY ANALYZING DATA FROM...)......................................................................................... 21 6 Trends of ratio of annual precipitation amount of Culver City (CC) and Pasadena (PA)...................................................................................... 23 7 The relationship between precipitation and TSP...

  18. Time series study of urban rainfall suppression during clean-up periods 

    E-Print Network [OSTI]

    Geng, Jun

    2008-10-10T23:59:59.000Z

    . Effects of Pollutant Aerosols on Precipitation……………….... 3 3. Our Focus………………………………………………………. 6 II STUDY OF SUPPRESSION OF PRECIPITATION IN AIR POLLUTIONS BY ANALYZING DATA FROM...)......................................................................................... 21 6 Trends of ratio of annual precipitation amount of Culver City (CC) and Pasadena (PA)...................................................................................... 23 7 The relationship between precipitation and TSP...

  19. LOCALLY WEIGHTED TOTAL VARIATION DENOISING FOR RINGING ARTIFACT SUPPRESSION IN PET RECONSTRUCTION USING PSF

    E-Print Network [OSTI]

    with PSF modeling is now implemented and widely used in clinical PET/CT systems. Some work has been doneLOCALLY WEIGHTED TOTAL VARIATION DENOISING FOR RINGING ARTIFACT SUPPRESSION IN PET RECONSTRUCTION tomography (PET) images, but also introduces ringing artifacts and over enhancement that is contrast

  20. Vibration Suppression and Optimal Repetitive Disturbance Rejection Control in Semi-Nyquist Frequency Region using

    E-Print Network [OSTI]

    Fujimoto, Hiroshi

    suppression and disturbance rejec- tion even in the semi-Nyquist frequency region. First, the continuous and to reject disturbance in high frequency re- gion because the Nyquist frequency is relatively low-sample performance to reject disturbance in the semi-Nyquist frequency region [6]. On the other hand, authors

  1. Nuclear absorption and anomalous J/psi suppression in Pb+Pb collisions

    E-Print Network [OSTI]

    A. K. Chaudhuri

    2002-07-29T23:59:59.000Z

    We have studied the J/psi suppression in 158 GeV/c Pb+Pb collisions at CERN SPS. J/psi production is assumed to be a two step process, (i) formation of c bar{c} pair, which is accurately calculable in QCD and (ii) formation of J/psi meson from the c bar{c} pair, which can be conveniently parameterized. In a pA/AA collision, as the c bar{c} pair pass through the nuclear medium, it gains relative square momentum. As a result, some of the c bar{c} pairs can gain enough momentum to cross the threshold to become open charm meson, leading to suppression in pA/AA collisions. The model without any free parameter could describe the of NA50 data on centrality dependence of the ratio's; J/psi over Drell-Yan, J/psi over minimum bias and also the Drell-Yan over minimum bias. The model was used to predict J/psi suppression at RHIC energy. At RHIC energy, hard processes may be important. With hard processes included, J/psi's are strongly suppressed, in agreement with other model calculations. We also show that centrality dependence of J/psi over minimum bias ratio can be used to determine the fraction of hard processes in the collision.

  2. Buckling suppression of SiGe islands on compliant substrates Haizhou Yina)

    E-Print Network [OSTI]

    Duffy, Thomas S.

    Buckling suppression of SiGe islands on compliant substrates Haizhou Yina) Center for Photonics structure made of SiGe and a cap layer were studied by both modeling and experiment. Both epitaxial silicon and accelerate the lateral relaxation, so that larger, flat, relaxed SiGe islands can be achieved. Using a 31 nm

  3. Freckle suppression in directional solidification of binary and multicomponent alloys using magnetic fields

    E-Print Network [OSTI]

    Zabaras, Nicholas J.

    a Lorentz force that opposes the thermosolutal buoyancy force and can be used to control or suppress melt coupling the electromagnetic and fluid flow phenomena. The induced electric potential depends on the fluid heating effect is neglected in the energy equation because of the high electrical conductivity of most

  4. Fractal dimension based sand ripple suppression for mine hunting with sidescan sonar

    E-Print Network [OSTI]

    Nelson, James

    mine hunting. Manual inspection of such data can be a time consuming task that requires significant1 Fractal dimension based sand ripple suppression for mine hunting with sidescan sonar J. D. B. Nelson and N. G. Kingsbury Abstract--Sand ripples present a difficult challenge to current mine hunting

  5. Enhancement of cloud cover and suppression of nocturnal drizzle in stratocumulus polluted by haze

    E-Print Network [OSTI]

    to amplify the negative radiative forcing by increasing cloud cover and cloud water [Albrecht, 1989]. [3] We in ship tracks [Ackerman et al., 2000]. Evidence for secondary effects is ambiguous. Cloud cover is seenEnhancement of cloud cover and suppression of nocturnal drizzle in stratocumulus polluted by haze A

  6. $?(2S)$, $?(3S)$ Suppression in p-Pb, Pb-Pb Collisions and Mixed Hybrid Theory

    E-Print Network [OSTI]

    Leonard S. Kisslinger

    2015-03-03T23:59:59.000Z

    We use our mixed hybrid model for the $\\Psi(2S)$ state to estimate $\\Psi(2S)$ to $J/\\Psi(1S)$ suppression in p-Pb collisions, and the $\\Upsilon(3S)$ state to estimate $\\Upsilon(3S)$ to $\\Upsilon(1S)$ suppression in Pb-Pb collisions, and compare to recent experimental measurements.

  7. Fusion Technologies for Tritium-Suppressed D-D Fusion White Paper prepared for FESAC Materials Science Subcommittee

    E-Print Network [OSTI]

    1 Fusion Technologies for Tritium-Suppressed D-D Fusion White Paper prepared for FESAC Materials, Columbia University 2 Plasma Science and Fusion Center, MIT December 19, 2011 Summary The proposal for tritium-suppressed D-D fusion and the understanding of the turbulent pinch in magnetically confined plasma

  8. Dynamical suppression of sea level rise along the Pacific coast of North America: Indications for imminent acceleration

    E-Print Network [OSTI]

    Bromirski, Peter D.

    Dynamical suppression of sea level rise along the Pacific coast of North America: Indications changes in global mean sea level (MSL) rise have important practical implications for shoreline and beach occurred after the mid1970s regime shift, can account for the suppression of regional sea level rise along

  9. An assessment of alternatives and technologies for replacing ozone- depleting substances at DOE facilities

    SciTech Connect (OSTI)

    Purcell, C.W.; Miller, K.B.; Friedman, J.R.; Rapoport, R.D.; Conover, D.R.; Hendrickson, P.L. [Pacific Northwest Lab., Richland, WA (United States); Koss, T.C. [USDOE Assistant Secretary for Environment, Safety, and Health, Washington, DC (United States). Office of Environmental Guidance

    1992-10-01T23:59:59.000Z

    Title VI of the Clean Air Act, as amended, mandates a production phase-out for ozone-depleting substances (ODSs). These requirements will have a significant impact on US Department of Energy (DOE) facilities. Currently, DOE uses ODSs in three major activities: fire suppression (halon), refrigeration and cooling (chlorofluorocarbons [CFCs]), and cleaning that requires solvents (CFCs, methyl chloroform, and carbon tetrachloride). This report provides basic information on methods and strategies to phase out use of ODSs at DOE facilities.

  10. ELM Suppression in Low Edge Collisionality H-Mode Discharges Using n=3 Magnetic Perturbations

    SciTech Connect (OSTI)

    Burrell, K H; Evans, T E; Doyle, E J; Fenstermacher, M E; Groebner, R J; Leonard, A W; Moyer, R A; Osborne, T H; Schaffer, M J; Snyder, P B; Thomas, P R; West, W P; Boedo, J A; Garofalo, A M; Gohil, P; Jackson, G L; La Haye, R J; Lasnier, C J; Reimerdes, H; Rhodes, T L; Scoville, J T; Solomon, W M; Thomas, D M; Wang, G; Watkins, J G; Zeng, L

    2005-07-11T23:59:59.000Z

    Using resonant magnetic perturbations with toroidal mode number n = 3, we have produced H-mode discharges without edge localized modes (ELMs) which run with constant density and radiated power for periods up to about 2550 ms (17 energy confinement times). These ELM suppression results are achieved at pedestal collisionalities close to those desired for next step burning plasma experiments such as ITER and provide a means of eliminating the rapid erosion of divertor components in such machines which could be caused by giant ELMs. The ELM suppression is due to an enhancement in the edge particle transport which reduces the edge pressure gradient and pedestal current density below the threshold for peeling-ballooning modes. These n = 3 magnetic perturbations provide a means of active control of edge plasma transport.

  11. Suppression of Tritium Retention in Remote Areas of ITER by Nonperturbative Reactive Gas Injection

    SciTech Connect (OSTI)

    Tabares, F. L.; Ferreira, J. A.; Ramos, A. [As Euratom-Ciemat, Av Complutense 22, 28040 Madrid (Spain); Rooij, G. van; Westerhout, J.; Al, R.; Rapp, J. [FOM Instituut voor Plasmafysica Rijnhuizen, EURATOM Association, TEC, PO Box 1207, 3430 BE Nieuwegein (Netherlands); Drenik, A.; Mozetic, M. [As Euratom-MHEST, Institut Jozef Stefan, Jamova cesta 39, 1000 Ljubljana (Slovenia)

    2010-10-22T23:59:59.000Z

    A technique based on reactive gas injection in the afterglow region of the divertor plasma is proposed for the suppression of tritium-carbon codeposits in remote areas of ITER when operated with carbon-based divertor targets. Experiments in a divertor simulator plasma device indicate that a 4 nm/min deposition can be suppressed by addition of 1 Pa{center_dot}m{sup 3} s{sup -1} ammonia flow at 10 cm from the plasma. These results bolster the concept of nonperturbative scavenger injection for tritium inventory control in carbon-based fusion plasma devices, thus paving the way for ITER operation in the active phase under a carbon-dominated, plasma facing component background.

  12. Transport enhancement and suppression in turbulent magnetic reconnection: A self-consistent turbulence model

    SciTech Connect (OSTI)

    Yokoi, N. [Institute of Industrial Science, University of Tokyo, Tokyo (Japan)] [Institute of Industrial Science, University of Tokyo, Tokyo (Japan); Higashimori, K.; Hoshino, M. [Department of Earth and Planetary Science, University of Tokyo, Tokyo (Japan)] [Department of Earth and Planetary Science, University of Tokyo, Tokyo (Japan)

    2013-12-15T23:59:59.000Z

    Through the enhancement of transport, turbulence is expected to contribute to the fast reconnection. However, the effects of turbulence are not so straightforward. In addition to the enhancement of transport, turbulence under some environment shows effects that suppress the transport. In the presence of turbulent cross helicity, such dynamic balance between the transport enhancement and suppression occurs. As this result of dynamic balance, the region of effective enhanced magnetic diffusivity is confined to a narrow region, leading to the fast reconnection. In order to confirm this idea, a self-consistent turbulence model for the magnetic reconnection is proposed. With the aid of numerical simulations where turbulence effects are incorporated in a consistent manner through the turbulence model, the dynamic balance in the turbulence magnetic reconnection is confirmed.

  13. NO.sub.x catalyst and method of suppressing sulfate formation in an exhaust purification system

    DOE Patents [OSTI]

    Balmer-Millar, Mari Lou (Chillicothe, IL); Park, Paul W. (Peoria, IL); Panov, Alexander G. (Peoria, IL)

    2007-06-26T23:59:59.000Z

    The activity and durability of a zeolite lean-burn NOx catalyst can be increased by loading metal cations on the outer surface of the zeolite. However, the metal loadings can also oxidize sulfur dioxide to cause sulfate formation in the exhaust. The present invention is a method of suppressing sulfate formation in an exhaust purification system including a NO.sub.x catalyst. The NO.sub.x catalyst includes a zeolite loaded with at least one metal. The metal is selected from among an alkali metal, an alkaline earth metal, a lanthanide metal, a noble metal, and a transition metal. In order to suppress sulfate formation, at least a portion of the loaded metal is complexed with at least one of sulfate, phosphate, and carbonate.

  14. SURFACE FILMS TO SUPPRESS FIELD EMISSION IN HIGH-POWER MICROWAVE COMPONENTS

    SciTech Connect (OSTI)

    Hirshfield, Jay l

    2014-02-07T23:59:59.000Z

    Results are reported on attempts to reduce the RF breakdown probability on copper accelerator structures by applying thin surface films that could suppress field emission of electrons. Techniques for application and testing of copper samples with films of metals with work functions higher than copper are described, principally for application of platinum films, since platinum has the second highest work function of any metal. Techniques for application of insulating films are also described, since these can suppress field emission and damage on account of dielectric shielding of fields at the copper surface, and on account of the greater hardness of insulating films, as compared with copper. In particular, application of zirconium oxide films on high-field portions of a 11.424 GHz SLAC cavity structure for breakdown tests are described.

  15. Alternative approach for fire suppression of class A, B and C fires in gloveboxes

    SciTech Connect (OSTI)

    Rosenberger, Mark S [Los Alamos National Laboratory; Tsiagkouris, James A [Los Alamos National Laboratory

    2011-02-10T23:59:59.000Z

    Department of Energy (DOE) Orders and National Fire Protection Association (NFPA) Codes and Standards require fire suppression in gloveboxes. Several potential solutions have been and are currently being considered at Los Alamos National Laboratory (LANL). The objective is to provide reliable, minimally invasive, and seismically robust fire suppression capable of extinguishing Class A, B, and C fires; achieve compliance with DOE and NFPA requirements; and provide value-added improvements to fire safety in gloveboxes. This report provides a brief summary of current approaches and also documents the successful fire tests conducted to prove that one approach, specifically Fire Foe{trademark} tubes, is capable of achieving the requirement to provide reliable fire protection in gloveboxes in a cost-effective manner.

  16. Suppression of turbulence and subcritical fluctuations in differentially rotating gyrokinetic plasmas

    E-Print Network [OSTI]

    Schekochihin, A A; Cowley, S C

    2011-01-01T23:59:59.000Z

    Differential rotation is known to suppress linear instabilities in fusion plasmas. However, even in the absence of growing eigenmodes, subcritical fluctuations that grow transiently can lead to sustained turbulence. Here transient growth of electrostatic fluctuations driven by the parallel velocity gradient (PVG) and the ion temperature gradient (ITG) in the presence of a perpendicular ExB velocity shear is considered. The maximally simplified case of zero magnetic shear is treated in the framework of a local shearing box. There are no linearly growing eigenmodes, so all excitations are transient. The maximal amplification factor of initial perturbations and the corresponding wavenumbers are calculated as functions of q/\\epsilon (=safety factor/aspect ratio), temperature gradient and velocity shear. Analytical results are corroborated and supplemented by linear gyrokinetic numerical tests. For sufficiently low values of q/\\epsilon (<7 in our model), regimes with fully suppressed ion-scale turbulence are po...

  17. System and method that suppresses intensity fluctuations for free space high-speed optical communication

    DOE Patents [OSTI]

    Berman, Gennady P. (Los Alamos, NM); Bishop, Alan R. (Los Alamos, NM); Nguyen, Dinh C. (Los Alamos, NM); Chernobrod, Boris M. (Santa Fe, NM); Gorshkov, Vacheslav N. (Kiev, UA)

    2009-10-13T23:59:59.000Z

    A high-speed (Gbps), free space optical communication system is based on spectral encoding of radiation from a wide band light source, such as a laser. By using partially coherent laser beams in combination with a relatively slow photosensor, scintillations can be suppressed by orders of magnitude for distances of more than 10 km. To suppress the intensity fluctuations due to atmospheric turbulence, a source with partial transverse coherence in combination with slow response time photodetector is used. Information is encoded in the spectral domain of a wideband optical source by modulation of spectral amplitudes. A non-coherent light source with wide spectrum (an LED, for example) may be used for high-speed communication over short (less than about a mile) distances.

  18. Jet suppression of pions and single electrons at Au+Au collisions at RHIC

    E-Print Network [OSTI]

    Magdalena Djordjevic

    2011-05-30T23:59:59.000Z

    Jet suppression is considered to be a powerful tool to study the properties of a QCD medium created in ultra-relativistic heavy ion collisions. However, theoretical predictions obtained by using jet energy loss in static QCD medium show disagreement with experimental data, which is known as the heavy flavor puzzle at RHIC. We calculate the suppression patterns of pions and single electrons for Au+Au collisions at RHIC by including the energy loss in a finite size dynamical QCD medium, with finite magnetic mass effects taken into account. In contrast to the static case, we here report a good agreement with the experimental results, where this agreement is robust with respect to magnetic mass values. Therefore, the inclusion of dynamical QCD medium effects provides a reasonable explanation of the heavy flavor puzzle at RHIC.

  19. Bulk viscosity-driven suppression of shear viscosity effects on the flow harmonics at RHIC

    E-Print Network [OSTI]

    J. Noronha-Hostler; J. Noronha; F. Grassi

    2014-06-19T23:59:59.000Z

    The interplay between shear and bulk viscosities on the flow harmonics, $v_n$'s, at RHIC is investigated using the newly developed relativistic 2+1 hydrodynamical code v-USPhydro that includes bulk and shear viscosity effects both in the hydrodynamic evolution and also at freeze-out. While shear viscosity is known to attenuate the flow harmonics, we find that the inclusion of bulk viscosity decreases the shear viscosity-induced suppression of the flow harmonics bringing them closer to their values in ideal hydrodynamical calculations. Depending on the value of the bulk viscosity to entropy density ratio, $\\zeta/s$, in the quark-gluon plasma, the bulk viscosity-driven suppression of shear viscosity effects on the flow harmonics may require a re-evaluation of the previous estimates of the shear viscosity to entropy density ratio, $\\eta/s$, of the quark-gluon plasma previously extracted by comparing hydrodynamic calculations to heavy ion data.

  20. Reversible electron beam heating for suppression of microbunching instabilities at free-electron lasers

    E-Print Network [OSTI]

    Behrens, Christopher; Xiang, Dao

    2011-01-01T23:59:59.000Z

    The presence of microbunching instabilities due to the compression of high-brightness electron beams at existing and future X-ray free-electron lasers (FELs) results in restrictions on the attainable lasing performance and renders beam imaging with optical transition radiation impossible. The instability can be suppressed by introducing additional energy spread, i.e., "heating" the electron beam, as demonstrated by the successful operation of the laser heater system at the Linac Coherent Light Source. The increased energy spread is typically tolerable for self-amplified spontaneous emission FELs but limits the effectiveness of advanced FEL schemes such as seeding. In this paper, we present a reversible electron beam heating system based on two transverse deflecting radio-frequency structures (TDSs) in front and behind a magnetic bunch compressor chicane. The additional energy spread will be introduced in the first TDS, which suppresses the microbunching instability, and then will be eliminated in the second T...

  1. Suppression of space broadening of exciton polariton beams by Bloch oscillation effects

    E-Print Network [OSTI]

    Duan, Xudong; Zhang, Yongyou

    2015-01-01T23:59:59.000Z

    We theoretically study the transport of exciton polaritons under different applied photon potentials. The relation between the photon potentials and the thickness of the cavity layer is calculated by the finite element simulation. The theoretical analysis and numerical calculation indicate that the cavity photon potential is proportional to the thickness of the cavity layer with the coefficient being about $1.8$ meV/nm. Further, the periodic and linear photon potentials are considered to control the transport of the exciton polaritons in weak- and strong-field pump situations. In both situations the periodic potential cannot by itself effectively suppress the scatterings of the disorder potentials of the cavity photons and excitons and the nonlinear exciton-exciton interaction. When the linear potential is added to the cavity photons, the polariton transport exhibits the Bloch oscillation behavior. Importantly, the polariton Bloch oscillation can strongly suppress the space broadening due to the disorder pote...

  2. Argus: An L-Band Array for Detection of Astronomical Transients Steven W. Ellingson

    E-Print Network [OSTI]

    Ellingson, Steven W.

    component of gamma ray bursts (e.g., [2], [3]) and the intermittent "giant pulses" generated by some pulsars

  3. Optical system for Argus 355-nm 90-mm aperture target-illumination experiments

    SciTech Connect (OSTI)

    Johnson, B.C.; Boyd, R.; Hermes, G.; Hildum, J.S.; Linford, G.; Martin, W.E.

    1982-02-01T23:59:59.000Z

    The requirements of laser alignment, crystal tuning, target alignment, and laser beam diagnosis are provided by this optical system. Initial setup and preshot alignment techniques are discussed. Layout and operation are contrasted with the 532 nm target experiments.

  4. ARG-US RADIO FREQUENCY IDENTIFICATION (RFID) Technology (IN-08-046) -

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del(ANL-IN-03-032)8Li (59AJ76) (See theDoctoral20ALSNewstt^APPLIANCE STANDARDS

  5. Advances in the Understanding of ELM Suppression by Resonant Magnetic Perturbations (RMPs) in DIII-D and Implications for ITER

    SciTech Connect (OSTI)

    Nazikian, R. [PPPL

    2014-09-01T23:59:59.000Z

    Experiments on DIII-D have expanding the operating window for RMP ELM suppression to higher q95 with dominant electron heating and fully non-inductive current drive relevant to advanced modes of ITER operation. Robust ELM suppression has also been obtained with a reduced coil set, mitigating the risk of coil failure in maintaining ELM suppression in ITER. These results significantly expand the operating space and reduce risk for obtaining RMP ELM suppression in ITER. Efforts have also been made to search for 3D cause of ELM suppression. No internal non-axisymmetric structure is detected at the top of the pedestal, indicating that the dominant effect of the RMP is to produce an n=0 transport modification of the profiles. Linear two fluid MHD simulations using M3D-C1 indicate resonant field penetration and significant magnetic stochasticity at the top of the pedestal, consistent with the absence of detectable 3D structure in that region. A profile database was developed to compare the scaling of the pedestal and global confinement with the applied 3D field strength in ELM suppressed and ELM mitigated plasmas. The EPED pedestal model accurately predicts the measured pedestal pressure at the threshold of ELM suppression, increasing confidence in theoretical projections to ITER pedestal conditions. Both the H-factor (H(sub)98y2) and thermal energy confinement time do not degrade substantially with applied RMP fields near the threshold of ELM suppression, enhancing confidence in the compatibility of ITER high performance operation with RMP ELM suppression.

  6. Instability suppression of clusters of vector-necklace-ring solitons in nonlocal media

    SciTech Connect (OSTI)

    Shen Ming [Department of Physics, Shanghai University, 99 Shangda Road, Shanghai 200444 (China); Institute of Photonics Technologies, National Tsing-Hua University, Hsinchu 300, Taiwan (China); Department of Physics, National Chung-Hsing University, Taichung 402, Taiwan (China); Kong Qian [Department of Physics, Shanghai University, 99 Shangda Road, Shanghai 200444 (China); Laser Physics Center, Research School of Physics and Engineering, Australian National University, Canberra ACT 0200 (Australia); Jeng, Chien-Chung [Department of Physics, National Chung-Hsing University, Taichung 402, Taiwan (China); Ge Lijuan [Department of Physics, Shanghai University, 99 Shangda Road, Shanghai 200444 (China); Lee, Ray-Kuang [Institute of Photonics Technologies, National Tsing-Hua University, Hsinchu 300, Taiwan (China); Krolikowski, Wieslaw [Laser Physics Center, Research School of Physics and Engineering, Australian National University, Canberra ACT 0200 (Australia)

    2011-02-15T23:59:59.000Z

    We study the instability suppression of vector-necklace-ring soliton clusters carrying zero, integer, and fractional angular momentums in nonlocal nonlinear media with an arbitrary degree of nonlocality. We show that the combination of nonlocality and mutual trapping of soliton constituent components can completely stabilize the vector-necklace-ring soliton clusters which are otherwise only quasistable in local media. Our results may be useful to studies of the novel soliton states in Bose-Einstein with dipolar long-range interactions.

  7. Variation of jet quenching from RHIC to LHC and thermal suppression of QCD coupling constant

    E-Print Network [OSTI]

    B. G. Zakharov

    2011-05-10T23:59:59.000Z

    We perform a joint jet tomographic analysis of the data on the nuclear modification factor $R_{AA}$ from PHENIX at RHIC and ALICE at LHC. The computations are performed accounting for radiative and collisional parton energy loss with running coupling constant. Our results show that the observed slow variation of $R_{AA}$ from RHIC to LHC indicates that the QCD coupling constant is suppressed in the quark-gluon plasma produced at LHC.

  8. The evolution of sex ratio distorter suppression impacts across a 25cM genomic region

    E-Print Network [OSTI]

    Hornett, E. A.; Moran, B.; Reynolds, L. A.; Charlat, S.; Tazzyman, S.; Wedell, N.; Jiggins, C. D.; Hurst, G. D. D.

    2014-01-01T23:59:59.000Z

    transcriptome sequencing (see Methods and 121 Materials, NCBI SRA accession: SRP045735). These markers were then tested for co-segregation 122 with suppression in order to identify the linkage groups associated with male host survival. Female 123 butterflies... assembler to create the first set of Expressed Sequence Tags (EST) for H. bolina. The 488 trimmed reads have been deposited as one male, and one female, partial transcriptome datasets in 489 the NCBI SRA database, accession SRP045735. 490 491...

  9. Threshold model and the latest NA50 data on $J/?$ suppression in Pb+Pb collisions

    E-Print Network [OSTI]

    A. K. Chaudhuri

    2003-05-26T23:59:59.000Z

    Using the QGP motivated threshold model, where all the $J/\\psi$'s are suppressed above a threshold density, we have analyzed the latest version of the NA50 data on the centrality dependence of the $J/\\psi$ over Drell-Yan ratio. The data are not well explain in the model, unless the threshold density is largely smeared. Large smeared threshold density effectively excludes creation of any deconfined medium in the collision.

  10. Experimental investigation of sedimentation of LOCA - generated fibrous debris and sludge in BWR suppression pools

    SciTech Connect (OSTI)

    Souto, F.J.; Rao, D.V.

    1995-12-01T23:59:59.000Z

    Several tests were conducted in a 1:2.4 scale model of a Mark I suppression pool to investigate the behavior of fibrous insulation and sludge debris under LOCA conditions. NUKON{trademark} shreds, manually cut and tore up in a leaf shredder, and iron oxide particles were used to simulate fibrous and sludge debris, respectively. The suppression pool model included four downcomers fitted with pistons to simulate the steam-water oscillations during chugging expected during a LOCA. The study was conducted to provide debris settling velocity data for the models used in the BLOCKAGE computer code, developed to estimate the ECCS pump head loss due to clogging of the strainers with LOCA generated debris. The tests showed that the debris, both fibrous and particulate, remains fully mixed during chugging; they also showed that, during chugging, the fibrous debris underwent fragmentation into smaller sizes, including individual fibers. Measured concentrations showed that fibrous debris settled slower than the sludge, and that the settling behavior of each material is independent of the presence of the other material. Finally, these tests showed that the assumption of considering uniform debris concentration during strainer calculations is reasonable. The tests did not consider the effects of the operation of the ECCS on the transport of debris in the suppression pool.

  11. Forebay Computational Fluid Dynamics Modeling for The Dalles Dam to Support Vortex Suppress Device Studies

    SciTech Connect (OSTI)

    Rakowski, Cynthia L.; Richmond, Marshall C.; Serkowski, John A.

    2006-12-01T23:59:59.000Z

    A computational fluid dynamics (CFD) model was used in an investigation into the suppression of a surface vortex that forms and the south-most spilling bay at The Dalles Project. The CFD work complemented work at the prototype and the reduced-scale physical models. The CFD model was based on a model developed for other work in the forebay but had additional resolution added near the spillway. Vortex suppression devices (VSDs) were to placed between pier noses and/or in the bulkhead slot of the spillway bays. The simulations in this study showed that placing VSD structures or a combination of structures to suppress the vortex would still result in near-surface flows to be entrained in a vortex near the downstream spillwall. These results were supported by physical model and prototype studies. However, there was a consensus of the fish biologists at the physical model that the fish would most likely move north and if the fish went under the VSD it would immediately exit the forebay through the tainter gate and not get trapped between VSDs or the VSDs and the tainter gate if the VSDs were deep enough.

  12. Geant4 Model Validation of Compton Suppressed System for Process monitoring of Spent Fuel

    SciTech Connect (OSTI)

    Bender, Sarah; Unlu, Kenan; Orton, Christopher R.; Schwantes, Jon M.

    2013-05-01T23:59:59.000Z

    Nuclear material accountancy is of continuous concern for the regulatory, safeguards, and verification communities. In particular, spent nuclear fuel reprocessing facilities pose one of the most difficult accountancy challenges: monitoring highly radioactive, fluid sample streams in near real-time. The Multi-Isotope Process monitor will allow for near-real-time indication of process alterations using passive gamma-ray detection coupled with multivariate analysis techniques to guard against potential material diversion or to enhance domestic process monitoring. The Compton continuum from the dominant 661.7 keV 137Cs fission product peak obscures lower energy lines which could be used for spectral and multivariate analysis. Compton suppression may be able to mitigate the challenges posed by the high continuum caused by scattering. A Monte Carlo simulation using the Geant4 toolkit is being developed to predict the expected suppressed spectrum from spent fuel samples to estimate the reduction in the Compton continuum. Despite the lack of timing information between decay events in the particle management of Geant4, encouraging results were recorded utilizing only the information within individual decays without accounting for accidental coincidences. The model has been validated with single and cascade decay emitters in two steps: as an unsuppressed system and with suppression activated. Results of the Geant4 model validation will be presented.

  13. The Relationships Between ELM Suppression, Pedestal Profiles, and Lithium Wall Coatings in NSTX

    SciTech Connect (OSTI)

    D.P. Boyle, R. Maingi, P.B. Snyder, J. Manickam, T.H. Osborne, R.E. Bell, B.P. LeBlanc, and the NSTX Team

    2012-08-17T23:59:59.000Z

    Recently in the National Spherical Torus Experiment (NSTX), increasing lithium wall coatings suppressed edge localized modes (ELMs), gradually but not quite monotonically. This work details profile and stability analysis as ELMs disappeared throughout the lithium scan. While the quantity of lithium deposited between discharges did not uniquely determine the presence of ELMs, profile analysis demonstrated that lithium was correlated to wider density and pressure pedestals with peak gradients farther from the separatrix. Moreover, the ELMy and ELM-free discharges were cleanly separated by their density and pedestal widths and peak gradient locations. Ultimately, ELMs were only suppressed when lithium caused the density pedestal to widen and shift inward. These changes in the density gradient were directly reflected in the pressure gradient and calculated bootstrap current. This supports the theory that ELMs in NSTX are caused by peeling and/or ballooning modes, as kink/peeling modes are stabilized when the edge current and pressure gradient shift away from the separatrix. Edge stability analysis using ELITE corroborated this picture, as reconstructed equilibria from ELM-free discharges were generally farther from their kink/peeling stability boundaries than ELMy discharges. We conclude that density profile control provided by lithium is the key first step to ELM suppression in NSTX

  14. Knockdown of p53 suppresses Nanog expression in embryonic stem cells

    SciTech Connect (OSTI)

    Abdelalim, Essam Mohamed, E-mail: emohamed@qf.org.qa [Qatar Biomedical Research Institute, Qatar Foundation, Doha 5825 (Qatar); Molecular Neuroscience Research Center, Shiga University of Medical Science, Setatsukinowa-cho, Otsu, Shiga 520-2192 (Japan); Department of Cytology and Histology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia (Egypt); Tooyama, Ikuo [Molecular Neuroscience Research Center, Shiga University of Medical Science, Setatsukinowa-cho, Otsu, Shiga 520-2192 (Japan)] [Molecular Neuroscience Research Center, Shiga University of Medical Science, Setatsukinowa-cho, Otsu, Shiga 520-2192 (Japan)

    2014-01-10T23:59:59.000Z

    Highlights: •We investigate the role of p53 in ESCs in the absence of DNA damage. •p53 knockdown suppresses ESC proliferation. •p53 knockdown downregulates Nanog expression. •p53 is essential for mouse ESC self-renewal. -- Abstract: Mouse embryonic stem cells (ESCs) express high levels of cytoplasmic p53. Exposure of mouse ESCs to DNA damage leads to activation of p53, inducing Nanog suppression. In contrast to earlier studies, we recently reported that chemical inhibition of p53 suppresses ESC proliferation. Here, we confirm that p53 signaling is involved in the maintenance of mouse ESC self-renewal. RNA interference-mediated knockdown of p53 induced downregulation of p21 and defects in ESC proliferation. Furthermore, p53 knockdown resulted in a significant downregulation in Nanog expression at 24 and 48 h post-transfection. p53 knockdown also caused a reduction in Oct4 expression at 48 h post-transfection. Conversely, exposure of ESCs to DNA damage caused a higher reduction of Nanog expression in control siRNA-treated cells than in p53 siRNA-treated cells. These data show that in the absence of DNA damage, p53 is required for the maintenance of mouse ESC self-renewal by regulating Nanog expression.

  15. MEASUREMENTS OF ABSORPTION, EMISSIVITY REDUCTION, AND LOCAL SUPPRESSION OF SOLAR ACOUSTIC WAVES IN SUNSPOTS

    SciTech Connect (OSTI)

    Chou, D.-Y.; Liang, Z.-C.; Yang, M.-H.; Zhao Hui [Physics Department, National Tsing Hua University, Hsinchu, Taiwan (China); Sun, M.-T. [Department of Mechanical Engineering, Chang-Gung University, Kwei-San, Taiwan (China)], E-mail: chou@phys.nthu.edu.tw

    2009-05-01T23:59:59.000Z

    The power of solar acoustic waves in magnetic regions is lower relative to the quiet Sun. Absorption, emissivity reduction, and local suppression of acoustic waves contribute to the observed power reduction in magnetic regions. We propose a model for the energy budget of acoustic waves propagating through a sunspot in terms of the coefficients of absorption, emissivity reduction, and local suppression of the sunspot. Using the property that the waves emitted along the wave path between two points have no correlation with the signal at the starting point, we can separate the effects of these three mechanisms. Applying this method to helioseismic data filtered with direction and phase-velocity filters, we measure the fraction of the contribution of each mechanism to the power deficit in the umbra of the leading sunspot of NOAA 9057. The contribution from absorption is 23.3 {+-} 1.3%, emissivity reduction 8.2 {+-} 1.4%, and local suppression 68.5 {+-} 1.5%, for a wave packet corresponding to a phase velocity of 6.98 x 10{sup -5} rad s{sup -1}.

  16. MOLECULAR MECHANISM OF SUPPRESSION OF NEOPLASTIC TRANSFORMATION BY LOW DOSES OF LOW LET RADIATION

    SciTech Connect (OSTI)

    J.LESIE REDPATH, PH.D.

    2011-03-29T23:59:59.000Z

    We are currently funded (9/01-8/04) by the DOE Low Dose Radiation Research Program to examine mechanisms underlying the suppression of neoplastic transformation in vitro by low doses of low LET radiation. For the new studies proposed under Notice 04-21, we intend to follow up on our observation that upregulation of DNA repair may be an important factor and that its importance is dose-dependent. The experimental system will be the human hybrid cell neoplastic transformation assay that we are currently using. We propose to test the following hypothesis: Down-regulation of DNA dsb repair will abrogate the low dose suppression of neoplastic transformation. Using the technique of RNA silencing, it is proposed to test the effect of down-regulation of the two major DNA dsb repair pathways, homologous recombination (HR) and non-homologous end-joining (NHEJ), on the dose response relationship for neoplastic transformation. Based on prior studies, we predict that this will result in abrogation of the suppressive effect at doses in the range 1 to 10 cGy, but not at lower doses. The proposed experiments will also help address the question as to which of the two DNA repair pathways may be the most important in causing suppression of transformation. HR is a pathway that is predominant in S and G2 phase cells and is known to be less error-prone than the NHEJ pathway that is predominant in G1 phase. We hypothesize that down-regulation of HR will result in the most effective abrogation of suppression. An important component of this study will be the determination of the how abrogation of DNA dsb repair impacts the spontaneous transformation frequency, presumably a consequence of endogeneous DNA damage. Experiments will be carried out using partially synchronized populations of cells enriched for G1 and S/G2 respectively. In addition to the endpoint of neoplastic transformation the impact of down-regulation of HR and NHEJ on the formation and disappearance of the DNA dsb marker, gamma-H2AX, will be studied.

  17. CD8+ T cell antiviral activity: mechanism of induction and the suppression of emerging feline immunodeficiency virus strains 

    E-Print Network [OSTI]

    Phadke, Anagha

    2007-09-17T23:59:59.000Z

    In the present studies, the essential role of inducer cells for the induction of soluble anti-viral activity against feline immunodeficiency virus (FIV) was investigated. Induction of suppression of FIV replication was ...

  18. RapTOR: Automated sequencing library preparation and suppression for rapid pathogen characterization ( 7th Annual SFAF Meeting, 2012)

    ScienceCinema (OSTI)

    Lane, Todd [SNL

    2013-02-11T23:59:59.000Z

    Todd Lane on "RapTOR: Automated sequencing library preparation and suppression for rapid pathogen characterization" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  19. Suppression of the asymmetric modes for experimentally achieving gigawatt-level radiation from a Ku-band Cerenkov type oscillator

    SciTech Connect (OSTI)

    Zhang, Hua; Shu, Ting, E-mail: mrtingshu@qq.com; Ju, Jinchuan; Wu, Dapeng; Bai, Zhen [College of Optoelectric Science and Engineering, National University of Defense Technology, Changsha 410073 (China)

    2014-08-15T23:59:59.000Z

    We present the analysis and suppression of asymmetric modes in a Ku-band Cerenkov-type oscillator numerically and experimentally. The asymmetric modes generated in the initial experiments were identified to be HE{sub 11}, HE{sub 21}, and HE{sub 31} modes, respectively, by analyzing of the dispersion relationships, the simulation results and the experiment phenomenon. The factors, such as the cathode emission uniformity, the diode voltage, guiding magnetic field, and the concentricity play key roles in the excitation and suppression of these asymmetric modes. In the improved experiments, the asymmetric modes were suppressed effectively. In the improved experiments the asymmetric modes are suppressed effectively, and the designed TM{sub 01} mode microwave is generated at a frequency of 13.76 GHz with a power of 1.1 GW, which is in good agreement with numerically predications.

  20. RapTOR: Automated sequencing library preparation and suppression for rapid pathogen characterization ( 7th Annual SFAF Meeting, 2012)

    SciTech Connect (OSTI)

    Lane, Todd [SNL] [SNL

    2012-06-01T23:59:59.000Z

    Todd Lane on "RapTOR: Automated sequencing library preparation and suppression for rapid pathogen characterization" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  1. 1Lesions in the mRNA cap-binding gene ABA HYPERSENSITIVE 1 suppress FRIGIDA-mediated delayed

    E-Print Network [OSTI]

    Raines, Ronald T.

    1Lesions in the mRNA cap-binding gene ABA HYPERSENSITIVE 1 suppress FRIGIDA-mediated delayed morphology were identified in T-DNA and fast-neutron mutant populations. Molecular analysis showed

  2. A forced response analysis and application of impact dampers to rotordynamic vibration suppression in a cryogenic environment

    E-Print Network [OSTI]

    Moore, James Jeffrey

    1993-01-01T23:59:59.000Z

    A FORCED RESPONSE ANALYSIS AND APPLICATION OF IMPACT DAMPERS TO ROTORDYNAMIC VIBRATION SUPPRESSION IN A CRYOGENIC ENVIRONMENT A Thesis by JAMES JEFFREY MOORE Submitted to the Office of Graduate Studies of Texas ARM University in partial... fulfillment of the requirements for the degree of MASTER OF SCIENCE May 1993 Major Subject: Mechanical Engineering A FORCED RESPONSE ANALYSIS AND APPLICATION OF IMPACT DAMPERS TO ROTORDYNAMIC VIBRATION SUPPRESSION IN A CRYOGENIC ENVIRONMENT A Thesis...

  3. Effectiveness of two spraying systems for bollworm suppression, canopy penetration, and drift reduction in the Rolling Plains of Texas

    E-Print Network [OSTI]

    Robinson, John Robert Calvert

    1986-01-01T23:59:59.000Z

    EFFECTIVENESS OF TWO SPRAYING SYSTEMS FOR BOLLWORM SUPPRESSION, CANOPY PENETRATION, AND DRIFT REDUCTION IN THE ROLLING PLAINS OF TEXAS A Thesis by JOHN ROBERT CALVERT ROBINSON Submitted to the Graduate College of Texas A8B University... in partial fulfilment of the requirements for the degree of MASTER OF SCIENCE May 1986 Major Subject: Entomology EFFECTIVENESS OF TWO SPRAYING SYSTEMS FOR BOLLWORM SUPPRESSION, CANOPY PENETRATION, AND DRIFT REDUCTION IN THE ROLLING PLAINS OF TEXAS A...

  4. $J/?$ suppression and $p_T$ spectra in RHIC and LHC energy collisions

    E-Print Network [OSTI]

    A. K. Chaudhuri

    2008-11-24T23:59:59.000Z

    In a hydrodynamic model, we have studied $J/\\psi$ production in Au+Au/Cu+Cu collisions at RHIC energy $\\sqrt{s}$=200 GeV. At the initial time, $J/\\psi$'s are randomly distributed in the fluid. As the fluid evolve in time, the free streaming $J/\\psi$'s are dissolved if the local fluid temperature exceeds a threshold temperature $T_{J/\\psi}$. Sequential melting of charmonium states ($\\chi_c$, $\\psi\\prime$ and $J/\\psi$), with melting temperatures $T_{\\chi_c}=T_{\\psi\\prime} \\approx 1.2T_c$, $T_{J/\\psi} \\approx2T_c$ and feed-down fraction $F\\approx 0.3$, explains the PHENIX data on the centrality dependence of $J/\\psi$ suppression in Au+Au collisions. $J/\\psi$ $p_T$ spectra and the nuclear modification factor in Au+Au collisions are also well explained in the model. The model however over predict centrality dependence of $J/\\psi$ suppression in Cu+Cu collisions by 20-30%. The $J/\\psi$ $p_T$ spectra are under predicted by 20-30%. The model predict that in central Pb+Pb collisions at LHC energy, $\\sqrt{s}$=5500 GeV, $J/\\psi$'s are suppressed by a factor of $\\sim$ 10. The model predicted $J/\\psi$ $p_T$ distribution in Pb+Pb collisions at LHC is similar to that in Au+Au collisions at RHIC.

  5. Method and system for modulation of gain suppression in high average power laser systems

    DOE Patents [OSTI]

    Bayramian, Andrew James (Manteca, CA)

    2012-07-31T23:59:59.000Z

    A high average power laser system with modulated gain suppression includes an input aperture associated with a first laser beam extraction path and an output aperture associated with the first laser beam extraction path. The system also includes a pinhole creation laser having an optical output directed along a pinhole creation path and an absorbing material positioned along both the first laser beam extraction path and the pinhole creation path. The system further includes a mechanism operable to translate the absorbing material in a direction crossing the first laser beam extraction laser path and a controller operable to modulate the second laser beam.

  6. Search for the highly suppressed decays B- -> K+ pi- pi- and B- -> K- K- pi+

    E-Print Network [OSTI]

    The BABAR Collaboration; B. Aubert

    2008-11-14T23:59:59.000Z

    We report a search for the decays B- -> K+ pi- pi- and B- -> K- K- pi+, which are highly suppressed in the Standard Model. Using a sample of (467 +/- 5) x 10^6 BBbar pairs collected with the BaBar detector, we do not see any evidence of these decays and determine 90% confidence level upper limits of BF(B- -> K+ pi- pi-) K- K- pi+) < 1.6 x 10^-7 on the corresponding branching fractions, including systematic uncertainties.

  7. Experimental results of water film formation on various fuel forms from a fire suppression system

    SciTech Connect (OSTI)

    Ross, R.H.; Davis, J.R.

    1994-12-31T23:59:59.000Z

    The purpose of the study was to determine the thickness and coverage of water film formations on various materials during fire sprinkler deluge. The primary criticality safety concern with automatic fire suppression systems is the increased amount of water that a film adds to the interstitial volume of an array per unit time. An exhaustive literature search revealed that no applicable research data exist that govern water film formations from fire protection systems. Therefore, a controlled, infield, mockup was created to predict the thickness and coverage of water film on fissile material forms. This paper discusses the background, experimental procedure, and the characterization of these water films.

  8. Suppression of tin precipitation in SiSn alloy layers by implanted carbon

    SciTech Connect (OSTI)

    Gaiduk, P. I., E-mail: gaiduk@phys.au.dk [Department of Physics and Astronomy/iNANO, Aarhus University, Gustav Wieds Vej 14, DK-8000 Aarhus C (Denmark); Belarusian State University, prosp. Nezavisimosti 4, 220030 Minsk (Belarus); Lundsgaard Hansen, J., E-mail: johnlh@phys.au.dk; Nylandsted Larsen, A., E-mail: anl@phys.au.dk [Department of Physics and Astronomy/iNANO, Aarhus University, Gustav Wieds Vej 14, DK-8000 Aarhus C (Denmark); Bregolin, F. L., E-mail: f.lipp-bregolin@hzdr.de; Skorupa, W., E-mail: W.Skorupa@hzdr.de [Department of Semiconductor Materials, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstraße 400, 01328 Dresden (Germany)

    2014-06-09T23:59:59.000Z

    By combining transmission electron microscopy and Rutherford backscattering spectrometry, we have identified carbon related suppression of dislocations and tin precipitation in supersaturated molecular-beam epitaxial grown SiSn alloy layers. Secondary ion mass spectrometry has exposed the accumulation of carbon in the SiSn layers after high temperature carbon implantation and high temperature thermal treatment. Strain-enhanced separation of point defects and formation of dopant-defect complexes are suggested to be responsible for the effects. The possibility for carbon assisted segregation-free high temperature growth of heteroepitaxial SiSn/Si and GeSn/Si structures is argued.

  9. Suppression of dominant topographic overprints in gravity data by adaptive filtering: southern Wyoming Province

    E-Print Network [OSTI]

    Black, Ross A.

    1992-09-10T23:59:59.000Z

    . Surv. Prof. Pap. 793, 39 pp., 1973. Black, R. A., S. B. Smithson, and R. L. Kirlin, Adaptive filtering of gravity and topography data, western U.S. (abstract), Eos Trans./AGU, 68, 280, 1987. Clarke, G. K. C., Linear filters to suppress terrain... and uranium potential of Precambrian conglomerates in SE Wyoming: rep. DJBX-139-81, 551 pp., Bendix Field Engineering Corp., 1981. Klein, T. L., The geology and geochemistry of the sulphide deposits of the Seminoe District, Carbon Co. Wyoming, Ph...

  10. Generation and Suppression of Decoherence in Artificial Environment for Qubit System

    E-Print Network [OSTI]

    Yasushi Kondo; Mikio Nakahara; Shogo Tanimura; Sachiko Kitajima; Chikako Uchiyama; Fumiaki Shibata

    2007-02-10T23:59:59.000Z

    It is known that a quantum system with finite degrees of freedom can simulate a composite of a system and an environment if the state of the hypothetical environment is randomized by external manipulation. We show theoretically that any phase decoherence phenomena of a single qubit can be simulated with a two-qubit system and demonstrate experimentally two examples: one is phase decoherence of a single qubit in a transmission line, and the other is that in a quantum memory. We perform NMR experiments employing a two-spin molecule and clearly measure decoherence for both cases. We also prove experimentally that the bang-bang control efficiently suppresses decoherence.

  11. Strangeness Suppression in q-qbar Creation Observed in Exclusive Reactions

    E-Print Network [OSTI]

    K. Park; M. D. Mestayer; the CLAS collaboration

    2014-12-09T23:59:59.000Z

    We measured the ratios of electroproduction cross-sections from a proton target for three exclusive meson-baryon final states: $\\Lambda K^+$, $p\\pi^0$, and $n\\pi^+$, with the CLAS detector at Jefferson Lab. Using a simple model of quark hadronization we extract q-qbar creation probabilities for the first time in exclusive two-body production, in which only a single q-qbar pair is created. We observe a sizable suppression of strange quark-antiquark pairs compared to non-strange pairs, similar to that seen in high-energy production.

  12. Measurement of wakefield suppression in a detuned x-band accelerator structure

    SciTech Connect (OSTI)

    Adolphsen, C.; Bane, K.; Higo, T.; Kubo, K.; Miller, R.; Ruth, R.; Thompson, K.; Wang, J.

    1994-08-01T23:59:59.000Z

    Research is underway at SLAC to develop accelerator structures for a next generation linear collider. A full-scale prototype X-band structure has been built in which the dipole mode frequencies were detuned to suppress the long-range transverse wakefield by about two orders of magnitude. To verify that the detuning works as expected, a facility to measure the long-range wakefield, called the Accelerator Structure SETup, or ASSET, was constructed in the SLAC Linear Collider (SLC). This paper presents the results from the measurement of the prototype X-band structure with this facility.

  13. $J/\\psi$ suppression at FAIR energy collisions and QCD phase diagram

    E-Print Network [OSTI]

    Chaudhuri, A K

    2012-01-01T23:59:59.000Z

    Survival probability for $J/\\psi$'s in FAIR energy collisions is studied in a QGP motivated threshold model. In the threshold model $J/\\psi$'s are assumed to dissociate beyond a threshold temperature $T_{J/\\psi}$. Model parameters are obtained by analysing experimental data in $\\snn$=17.4 and 200 GeV collisions. In low energy collisions, model is sensitive to the QCD phase diagram. The model predicts that $J/\\psi$'s are least suppressed in $\\sqrt{s}_{NN}\\approx$ 40 GeV collisions.

  14. Suppression of Tin Whiskers in Lead-Free Solder - Energy Innovation Portal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over Our InstagramStructure ofIndustrialSupporting Data-ProducingSupportingSuppression of

  15. Soot suppression by ferrocene in laminar ethylene/air nonpremixed flames

    SciTech Connect (OSTI)

    Zhang, J.; Megaridis, C.M. [Univ. of Illinois, Chicago, IL (United States). Dept. of Mechanical Engineering] [Univ. of Illinois, Chicago, IL (United States). Dept. of Mechanical Engineering

    1996-06-01T23:59:59.000Z

    An experimental investigation is presented on the origin of the soot suppressing role of ferrocene additive in laminar, coannular, ethylene/air nonpremixed flames. The conditions examined involve laminar flames operating above and below their smoke point. In-flame diagnostics are employed to discern the interaction between the soot matrix and additive combustion products. The data presented in a previous study, as produced by thermophoretic sampling, transmission electron microscopy and high-resolution microanalysis techniques, are supplemented by soot volume fraction, temperature, and soot primary size measurements to unravel the mechanisms through which ferrocene combustion products influence soot formation processes. Furthermore, Z-contrast scanning/transmission electron microscopy is used to examine the over-fire aerosol and, in turn, provide insight on the fine-scale dispersion of iron fragments within the carbonaceous soot matrix. It is shown that ferrocene seeding of the fuel stream accelerates the particular inception mechanisms, but does not influence soot loadings when soot growth is dominant. Ferrocene is also found to enhance soot oxidation rates near the flame terminus. It is concluded that the fine-scale incorporation of iron compounds within the soot matrix is a primary factor for the soot suppressing role of ferrocene in nonpremixed flames.

  16. Deconfinement as an entropic self-destruction: a solution for the quarkonium suppression puzzle?

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Kharzeev, Dmitri E. [Stony Brook Univ, Department of Physics and Astronomy, NY (United States); Brookhaven National Laboratory, Department of Physics, Upton, NY (United States)

    2014-10-01T23:59:59.000Z

    The entropic approach to dissociation of bound states immersed in strongly coupled systems is developed. In such systems, the excitations of the bound state are often delocalized and characterized by a large entropy, so that the bound state is strongly entangled with the rest of the statistical system. If this entropy S increases with the separation r between the constituents of the bound state, S=S(r), then the resulting entropic force F=T ?S/?r (T is temperature) can drive the dissociation process. As a specific example, we consider the case of heavy quarkonium in strongly coupled quark-gluon plasma, where lattice QCD indicates a large amount of entropy associated with the heavy quark pair at temperatures 0.9Tc?T?1.5Tc (Tc is the deconfinement temperature); this entropy S(r) grows with the interquark distance r. We argue that the entropic mechanism results in an anomalously strong quarkonium suppression in the temperature range near Tc. This entropic self-destruction may thus explain why the experimentally measured quarkonium nuclear modification factor at RHIC (lower energy density) is smaller than at LHC (higher energy density), possibly resolving the “quarkonium suppression puzzle”—all of the previously known mechanisms of quarkonium dissociation operate more effectively at higher energy densities, and this contradicts the data. Moreover, we find that near Tc the entropic force leads to delocalization of the bound hadron states; we argue that this delocalization may be the mechanism underlying deconfinement.

  17. A sheet on deformable sphere: "wrinklogami" patterns suppress curvature-induced delamination

    E-Print Network [OSTI]

    Evan Hohlfeld; Benny Davidovitch

    2014-11-20T23:59:59.000Z

    The adhesion of a stiff film onto a curved substrate often generates elastic stresses in the film that eventually give rise to its delamination. Here we predict that delamination of very thin films can be dramatically suppressed through tiny, smooth deformations of the substrate, dubbed here "wrinklogami", that barely affect the macroscale topography. This "pro-lamination" effect reflects a surprising capability of smooth wrinkles to suppress compression in elastic films even when spherical or other doubly-curved topography is imposed, in a similar fashion to origami folds that enable construction of curved structures from an unstretchable paper. We show that the emergence of a wrinklogami pattern signals a nontrivial isometry of the sheet to its planar, undeformed state, in the doubly asymptotic limit of small thickness and weak tensile load exerted by the adhesive substrate. We explain how such an "asymptotic isometry" concept broadens the standard usage of isometries for describing the response of elastic sheets to geomertric constraints and mechanical loads.

  18. Suppressing the impact of a high tensor-to-scalar ratio on the temperature anisotropies

    E-Print Network [OSTI]

    Carlo R. Contaldi; Marco Peloso; Lorenzo Sorbo

    2014-07-05T23:59:59.000Z

    The BICEP2 collaboration has reported a strong B mode signal in the CMB polarization, which is well fit by a tensor-to-scalar ratio of r ~ 0.2. This is greater than the upper limit r data. The most advocated explanation involves a variation of n_s with scales (denoted as running) that has a magnitude significantly greater than the generic slow roll predictions. We instead study the possibility that the large scale temperature anisotropies are not enhanced because of a suppression of the scalar power at large scales. Such a situation can be achieved for instance by a sudden change of the speed of the inflaton (by about 14 %), and we show that it fits the temperature anisotropies and polarization data considerably better than a constant running (its chi^2 improves by ~ 7.5 over that of the constant running, at the cost of one more parameter). We also consider the possibility that the large scale temperature fluctuations are suppressed by an anti-correlation between tensor and scalar modes. Unfortunately, while such effect does affect the temperature fluctuations at large scales, it does not affect the temperature power spectrum and cannot, therefore, help in reconciling a large value of r with the limits from temperature fluctuations.

  19. Experiments in DIII-D toward achieving rapid shutdown with runaway electron suppression

    SciTech Connect (OSTI)

    Hollmann, E. M.; James, A. N.; Yu, J. H.; Izzo, V. A. [University of California, San Diego, La Jolla, California 92093-0417 (United States); Commaux, N.; Jernigan, T. C.; Baylor, L. R. [Oak Ridge National Laboratory, P.O. Box 2008, Oak Ridge, Tennessee 37831 (United States); Eidietis, N. W.; Parks, P. B.; Wesley, J. C.; Brooks, N. H.; Jackson, G. L.; Zeeland, M. A. van; Wu, W. [General Atomics, P.O. Box 85608, San Diego, California 92186-5608 (United States); Evans, T. E.; Humphreys, D. A.; Strait, E. J.; Austin, M. E. [Fusion Research Center, University of Texas at Austin, Austin, Texas 78712 (United States)

    2010-05-15T23:59:59.000Z

    Experiments have been performed in the DIII-D tokamak [J. L. Luxon, Nucl. Fusion 42, 614 (2002)] toward understanding runaway electron formation and amplification during rapid discharge shutdown, as well as toward achieving complete collisional suppression of these runaway electrons via massive delivery of impurities. Runaway acceleration and amplification appear to be well explained using the zero-dimensional (0D) current quench toroidal electric field. 0D or even one-dimensional modeling using a Dreicer seed term, however, appears to be too small to explain the initial runaway seed formation. Up to 15% of the line-average electron density required for complete runaway suppression has been achieved in the middle of the current quench using optimized massive gas injection with multiple small gas valves firing simultaneously. The novel rapid shutdown techniques of massive shattered pellet injection and shell pellet injection have been demonstrated for the first time. Experiments using external magnetic perturbations to deconfine runaways have shown promising preliminary results.

  20. Experiments in DIII-D toward achieving rapid shutdown with runaway electron suppression

    SciTech Connect (OSTI)

    Hollmann, E. M. [University of California, San Diego; Commaux, Nicolas JC [ORNL; Eidietis, N. W. [General Atomics, San Diego; Evans, T. E. [University of Texas, Austin; Humphreys, D. A. [University of Texas, Austin; James, A. N. [University of California, San Diego; Jernigan, T. C. [Oak Ridge National Laboratory (ORNL); Parks, P. B. [General Atomics; Strait, E. J. [University of Texas, Austin; Wesley, J. C. [General Atomics; Yu, J.H. [University of California, San Diego; Austin, M. E. [University of Texas, Austin; Baylor, Larry R [ORNL; Brooks, N. H. [General Atomics, San Diego; Izzo, V. A. [University of California, San Diego & La Jolla; Jackson, G. L. [General Atomics; Van Zeeland, M. A. [General Atomics, San Diego; Wu, W. [General Atomics, San Diego

    2010-01-01T23:59:59.000Z

    Experiments have been performed in the DIII-D tokamak [J. L. Luxon, Nucl. Fusion 42, 614 (2002)] toward understanding runaway electron formation and amplification during rapid discharge shutdown, as well as toward achieving complete collisional suppression of these runaway electrons via massive delivery of impurities. Runaway acceleration and amplification appear to be well explained using the zero-dimensional (0D) current quench toroidal electric field. 0D or even one-dimensional modeling using a Dreicer seed term, however, appears to be too small to explain the initial runaway seed formation. Up to 15% of the line-average electron density required for complete runaway suppression has been achieved in the middle of the current quench using optimized massive gas injection with multiple small gas valves firing simultaneously. The novel rapid shutdown techniques of massive shattered pellet injection and shell pellet injection have been demonstrated for the first time. Experiments using external magnetic perturbations to deconfine runaways have shown promising preliminary results. (C) 2010 American Institute of Physics. [doi:10.1063/1.3309426

  1. Deconfinement as an entropic self-destruction: a solution for the quarkonium suppression puzzle?

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Kharzeev, Dmitri E.

    2014-10-01T23:59:59.000Z

    The entropic approach to dissociation of bound states immersed in strongly coupled systems is developed. In such systems, the excitations of the bound state are often delocalized and characterized by a large entropy, so that the bound state is strongly entangled with the rest of the statistical system. If this entropy S increases with the separation r between the constituents of the bound state, S=S(r), then the resulting entropic force F=T ?S/?r (T is temperature) can drive the dissociation process. As a specific example, we consider the case of heavy quarkonium in strongly coupled quark-gluon plasma, where lattice QCD indicatesmore »a large amount of entropy associated with the heavy quark pair at temperatures 0.9Tc?T?1.5Tc (Tc is the deconfinement temperature); this entropy S(r) grows with the interquark distance r. We argue that the entropic mechanism results in an anomalously strong quarkonium suppression in the temperature range near Tc. This entropic self-destruction may thus explain why the experimentally measured quarkonium nuclear modification factor at RHIC (lower energy density) is smaller than at LHC (higher energy density), possibly resolving the “quarkonium suppression puzzle”—all of the previously known mechanisms of quarkonium dissociation operate more effectively at higher energy densities, and this contradicts the data. Moreover, we find that near Tc the entropic force leads to delocalization of the bound hadron states; we argue that this delocalization may be the mechanism underlying deconfinement.« less

  2. COMPLETE SUPPRESSION OF THE M=2/N-1 NEOCLASSICAL TEARING MODE USING ELECTRON CYCLOTRON CURRENT DRIVE ON DIII-D

    SciTech Connect (OSTI)

    PETTY,CC; LAHAYE,LA; LUCE,TC; HUMPHREYS,DA; HYATT,AW; PRATER,R; STRAIT,EJ; WADE,MR

    2003-03-01T23:59:59.000Z

    A271 COMPLETE SUPPRESSION OF THE M=2/N-1 NEOCLASSICAL TEARING MODE USING ELECTRON CYCLOTRON CURRENT DRIVE ON DIII-D. The first suppression of the important and deleterious m=2/n=1 neoclassical tearing mode (NTM) is reported using electron cyclotron current drive (ECCD) to replace the ''missing'' bootstrap current in the island O-point. Experiments on the DIII-D tokamak verify the maximum shrinkage of the m=2/n=1 island occurs when the ECCD location coincides with the q = 2 surface. The DIII-D plasma control system is put into search and suppress mode to make small changes in the toroidal field to find and lock onto the optimum position, based on real time measurements of dB{sub {theta}}/dt, for complete m=2/n=1 NTM suppression by ECCD. The requirements on the ECCD for complete island suppression are well modeled by the modified Rutherford equation for the DIII-D plasma conditions.

  3. Calculation of Fire Severity Factors and Fire Non-Suppression Probabilities For A DOE Facility Fire PRA

    SciTech Connect (OSTI)

    Tom Elicson; Bentley Harwood; Jim Bouchard; Heather Lucek

    2011-03-01T23:59:59.000Z

    Over a 12 month period, a fire PRA was developed for a DOE facility using the NUREG/CR-6850 EPRI/NRC fire PRA methodology. The fire PRA modeling included calculation of fire severity factors (SFs) and fire non-suppression probabilities (PNS) for each safe shutdown (SSD) component considered in the fire PRA model. The SFs were developed by performing detailed fire modeling through a combination of CFAST fire zone model calculations and Latin Hypercube Sampling (LHS). Component damage times and automatic fire suppression system actuation times calculated in the CFAST LHS analyses were then input to a time-dependent model of fire non-suppression probability. The fire non-suppression probability model is based on the modeling approach outlined in NUREG/CR-6850 and is supplemented with plant specific data. This paper presents the methodology used in the DOE facility fire PRA for modeling fire-induced SSD component failures and includes discussions of modeling techniques for: • Development of time-dependent fire heat release rate profiles (required as input to CFAST), • Calculation of fire severity factors based on CFAST detailed fire modeling, and • Calculation of fire non-suppression probabilities.

  4. Fission-suppressed fusion breeder on the thorium cycle and nonproliferation

    SciTech Connect (OSTI)

    Moir, R. W. [Vallecitos Molten Salt Research, 607 E. Vallecitos Rd., Livermore, CA 94550 925-447-8804 (United States)

    2012-06-19T23:59:59.000Z

    Fusion reactors could be designed to breed fissile material while suppressing fissioning thereby enhancing safety. The produced fuel could be used to startup and makeup fuel for fission reactors. Each fusion reaction can produce typically 0.6 fissile atoms and release about 1.6 times the 14 MeV neutron's energy in the blanket in the fission-suppressed design. This production rate is 2660 kg/1000 MW of fusion power for a year. The revenues would be doubled from such a plant by selling fuel at a price of 60/g and electricity at $0.05/kWh for Q=P{sub fusion}/P{sub input}=4. Fusion reactors could be designed to destroy fission wastes by transmutation and fissioning but this is not a natural use of fusion whereas it is a designed use of fission reactors. Fusion could supply makeup fuel to fission reactors that were dedicated to fissioning wastes with some of their neutrons. The design for safety and heat removal and other items is already accomplished with fission reactors. Whereas fusion reactors have geometry that compromises safety with a complex and thin wall separating the fusion zone from the blanket zone where wastes could be destroyed. Nonproliferation can be enhanced by mixing {sup 233}U with {sup 238}U. Also nonproliferation is enhanced in typical fission-suppressed designs by generating up to 0.05 {sup 232}U atoms for each {sup 233}U atom produced from thorium, about twice the IAEA standards of 'reduced protection' or 'self protection.' With 2.4%{sup 232}U, high explosive material is predicted to degrade owing to ionizing radiation after a little over 1/2 year and the heat rate is 77 W just after separation and climbs to over 600 W ten years later. The fissile material can be used to fuel most any fission reactor but is especially appropriate for molten salt reactors (MSR) also called liquid fluoride thorium reactors (LFTR) because of the molten fuel does not need hands on fabrication and handling.

  5. Suppression of the asymmetric competition mode in the relativistic Ku-band coaxial transit-time oscillator

    SciTech Connect (OSTI)

    Ling, Junpu; He, Juntao; Zhang, Jiande; Jiang, Tao; Wang, Lei [College of Optoelectronic Science and Engineering, National University of Defense Technology, Changsha 410073 (China)

    2014-10-15T23:59:59.000Z

    A relativistic Ku-band coaxial transit-time oscillator has been proposed in our previous work. In the experiments, we find that the asymmetric competition mode in the device limits the microwave power with the increase of the input electric power. For solving such a problem, the methods for analysis and suppression of the asymmetric competition mode in the device are investigated theoretically and experimentally. It is shown that the structure and the material of the collector, the concentricity, and the electron emission uniformity play an important part in the suppression of the asymmetric competition mode in the relativistic Ku-band transit-time oscillator. In the subsequent experiments, the asymmetric mode was suppressed effectively. At a low guiding magnetic field of 0.7?T, a microwave pulse with power of 1?GW, frequency of 14.3?GHz close to the simulation one, and efficiency of 20% was generated.

  6. Suppression of Y production in d + Au + and Au + Au collisions at ?sNN =200 GeV

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    none,

    2014-07-01T23:59:59.000Z

    We report measurements of Upsilon meson production in p + p, d +Au, and Au+Aucollisions using the STAR detector at RHIC. We compare the Upsilon yield to the measured cross section in p + p collisions in order to quantify any modifications of the yield in cold nuclear matter using d +Au data and in hot nuclear matter using Au+Au data separated into three centrality classes. Our p +p measurement is based on three times the statistics of our previous result. We obtain a nuclear modification factor for Upsilon (1S + 2S + 3S) in the rapidity range |y| more »1 in d + Au collisions of RdAu = 0.79 ± 0.24(stat.) ± 0.03(syst.) ± 0.10(p + p syst.). A comparison with models including shadowing and initial state part on energy loss indicates the presence of additional cold-nuclear matter suppression. Similarly, in the top 10% most-central Au + Au collisions, we measure a nuclear modification factor of R AA = 0.49 ±0.1(stat.) ±0.02(syst.) ±0.06(p + p syst.), which is a larger suppression factor than that seen in cold nuclear matter. Our results are consistent with complete suppression of excited-state Upsilon mesons in Au + Au collisions. The additional suppression in Au + Au is consistent with the level expected in model calculations that include the presence of a hot, deconfined Quark–Gluon Plasma. However, understanding the suppression seen in d + Au is still needed before any definitive statements about the nature of the suppression in Au + Au can be made.« less

  7. Sequential melting of charmonium states in an expanding Quark Gluon Plasma and $J/?$ suppression at RHIC and LHC energy collisions

    E-Print Network [OSTI]

    A. K. Chaudhuri

    2008-07-04T23:59:59.000Z

    We have developed a hydrodynamic model to study sequential melting of charmonium states in an expanding QGP medium. According to the initial fluid temperature profile, $J/\\psi$'s are randomly distributed in the transverse plane. As the fluid evolve in time, the free streaming $J/\\psi$'s are suppressed if the local fluid temperature exceed a critical temperature. PHENIX data on the centrality dependence of $J/\\psi$ suppression in Au+Au collisions at mid-rapidity are explained by sequential melting of the charmonium states, $\\chi_c$, $\\psi\\prime$ and $J/\\psi$, in the expanding medium. The critical temperatures $T_{J/\\psi} \\approx2.09T_c$ and $T_\\chi=T_{\\chi_c}=T_{\\psi\\prime} \\approx 1.1T_c$ agree with lattice motivated calculations. The feed-down fraction $F$ depend on whether the cold nuclear matter effect is included or not. It changes from $F=0.3$ with cold nuclear matter effect included to $F=0.5$ when the effect is neglected. Model fails to reproduce the PHENIX data on the centrality dependence of $J/\\psi$ suppression in Cu+Cu collisions at mid-rapidity, indicating that the mechanism of $J/\\psi$ suppression is different in Au+Au and in Cu+Cu collisions. We also use the model to predict for the centrality dependence of $J/\\psi$ suppression in Pb+Pb collisions at LHC energy, $\\sqrt{s}$=5500 GeV. In LHC energy, $J/\\psi$'s are more suppressed in mid central collisions than in Au+Au collisions at RHIC energy.

  8. Suppression of upsilon Production in d + Au and Au + Au collisions at root s=200 GeV

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Adamczyk, L.; STAR Collaboration

    2014-07-01T23:59:59.000Z

    We report measurements of Upsilon meson production in p + p, d +Au, and Au+Aucollisions using the STAR detector at RHIC. We compare the Upsilon yield to the measured cross section in p + p collisions in order to quantify any modifications of the yield in cold nuclear matter using d +Au data and in hot nuclear matter using Au+Au data separated into three centrality classes. Our p +p measurement is based on three times the statistics of our previous result. We obtain a nuclear modification factor for Upsilon (1S + 2S + 3S) in the rapidity range |y| dAu = 0.79 ± 0.24(stat.) ± 0.03(syst.) ± 0.10(p + p syst.). A comparison with models including shadowing and initial state part on energy loss indicates the presence of additional cold-nuclear matter suppression. Similarly, in the top 10% most-central Au + Au collisions, we measure a nuclear modification factor of R AA = 0.49 ±0.1(stat.) ±0.02(syst.) ±0.06(p + p syst.), which is a larger suppression factor than that seen in cold nuclear matter. Our results are consistent with complete suppression of excited-state Upsilon mesons in Au + Au collisions. The additional suppression in Au + Au is consistent with the level expected in model calculations that include the presence of a hot, deconfined Quark–Gluon Plasma. However, understanding the suppression seen in d + Au is still needed before any definitive statements about the nature of the suppression in Au + Au can be made.

  9. Suppression of upsilon Production in d + Au and Au + Au collisions at root s=200 GeV

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Adamczyk, L.; STAR Collaboration

    2014-07-01T23:59:59.000Z

    We report measurements of Upsilon meson production in p + p, d +Au, and Au+Aucollisions using the STAR detector at RHIC. We compare the Upsilon yield to the measured cross section in p + p collisions in order to quantify any modifications of the yield in cold nuclear matter using d +Au data and in hot nuclear matter using Au+Au data separated into three centrality classes. Our p +p measurement is based on three times the statistics of our previous result. We obtain a nuclear modification factor for Upsilon (1S + 2S + 3S) in the rapidity range |y| more »1 in d + Au collisions of RdAu = 0.79 ± 0.24(stat.) ± 0.03(syst.) ± 0.10(p + p syst.). A comparison with models including shadowing and initial state part on energy loss indicates the presence of additional cold-nuclear matter suppression. Similarly, in the top 10% most-central Au + Au collisions, we measure a nuclear modification factor of R AA = 0.49 ±0.1(stat.) ±0.02(syst.) ±0.06(p + p syst.), which is a larger suppression factor than that seen in cold nuclear matter. Our results are consistent with complete suppression of excited-state Upsilon mesons in Au + Au collisions. The additional suppression in Au + Au is consistent with the level expected in model calculations that include the presence of a hot, deconfined Quark–Gluon Plasma. However, understanding the suppression seen in d + Au is still needed before any definitive statements about the nature of the suppression in Au + Au can be made.« less

  10. Observation of modulation speed enhancement, frequency modulation suppression, and phase noise reduction by detuned loading in a coupled-cavity semiconductor laser

    SciTech Connect (OSTI)

    Vahala, K.; Paslaski, J.; Yariv, A.

    1985-06-01T23:59:59.000Z

    Simultaneous direct modulation response enhancement, phase noise (linewidth) reduction, and frequency modulation suppression are produced in a coupled-cavity semiconductor laser by the detuned loading mechanism.

  11. Suppressing the non-Gaussian statistics of Renewable Power from Wind and Solar

    E-Print Network [OSTI]

    Anvari, M; Tabar, M Reza Rahimi; Wächter, M; Milan, P; Heinemann, D; Peinke, Joachim; Lorenz, E

    2015-01-01T23:59:59.000Z

    The power from wind and solar exhibits a nonlinear flickering variability, which typically occurs at time scales of a few seconds. We show that high-frequency monitoring of such renewable powers enables us to detect a transition, controlled by the field size, where the output power qualitatively changes its behaviour from a flickering type to a diffusive stochastic behaviour. We find that the intermittency and strong non-Gaussian behavior in cumulative power of the total field, even for a country-wide installation still survives for both renewable sources. To overcome the short time intermittency, we introduce a time-delayed feedback method for power output of wind farm and solar field that can change further the underlying stochastic process and suppress their strong non- gaussian fluctuations.

  12. Wide angle Compton scattering on the proton: study of power suppressed corrections

    E-Print Network [OSTI]

    Kivel, N

    2015-01-01T23:59:59.000Z

    We study the wide angle Compton scattering process on a proton within the soft collinear factorization (SCET) framework. The main purpose of this work is to estimate the effect due to certain power suppressed corrections. We consider all possible kinematical power corrections and also include the subleading amplitudes describing the scattering with nucleon helicity flip. Under certain assumptions we present a leading-order factorization formula for these amplitudes which includes the hard- and soft-spectator contributions. We apply the formalism and perform a phenomenological analysis of the cross section and asymmetries in the wide angle Compton scattering on a proton. We assume that in the relevant kinematical region where $-t,-u>2.5$~GeV$^{2}$ the dominant contribution is provided by the soft-spectator mechanism. The hard coefficient functions of the corresponding SCET operators are taken in the leading-order approximation. The analysis of existing cross section data shows that the contribution of the heli...

  13. Suppressing traffic-driven epidemic spreading by edge-removal strategies

    E-Print Network [OSTI]

    Yang, Han-Xin; Wang, Bing-Hong

    2015-01-01T23:59:59.000Z

    The interplay between traffic dynamics and epidemic spreading on complex networks has received increasing attention in recent years. However, the control of traffic-driven epidemic spreading remains to be a challenging problem. In this Brief Report, we propose a method to suppress traffic-driven epidemic outbreak by properly removing some edges in a network. We find that the epidemic threshold can be enhanced by the targeted cutting of links among large-degree nodes or edges with the largest algorithmic betweeness. In contrast, the epidemic threshold will be reduced by the random edge removal. These findings are robust with respect to traffic-flow conditions, network structures and routing strategies. Moreover, we find that the shutdown of targeted edges can effectively release traffic load passing through large-degree nodes, rendering a relatively low probability of infection to these nodes.

  14. Radar signal pre-processing to suppress surface bounce and multipath

    DOE Patents [OSTI]

    Paglieroni, David W; Mast, Jeffrey E; Beer, N. Reginald

    2013-12-31T23:59:59.000Z

    A method and system for detecting the presence of subsurface objects within a medium is provided. In some embodiments, the imaging and detection system operates in a multistatic mode to collect radar return signals generated by an array of transceiver antenna pairs that is positioned across the surface and that travels down the surface. The imaging and detection system pre-processes that return signal to suppress certain undesirable effects. The imaging and detection system then generates synthetic aperture radar images from real aperture radar images generated from the pre-processed return signal. The imaging and detection system then post-processes the synthetic aperture radar images to improve detection of subsurface objects. The imaging and detection system identifies peaks in the energy levels of the post-processed image frame, which indicates the presence of a subsurface object.

  15. Operation of a high purity germanium crystal in liquid argon as a Compton suppressed radiation spectrometer

    E-Print Network [OSTI]

    John L. Orrell; Craig E. Aalseth; John F. Amsbaugh; Peter J. Doe; Todd W. Hossbach

    2006-10-11T23:59:59.000Z

    A high purity germanium crystal was operated in liquid argon as a Compton suppressed radiation spectrometer. Spectroscopic quality resolution of less than 1% of the full-width half maximum of full energy deposition peaks was demonstrated. The construction of the small apparatus used to obtain these results is reported. The design concept is to use the liquid argon bath to both cool the germanium crystal to operating temperatures and act as a scintillating veto. The scintillation light from the liquid argon can veto cosmic-rays, external primordial radiation, and gamma radiation that does not fully deposit within the germanium crystal. This technique was investigated for its potential impact on ultra-low background gamma-ray spectroscopy. This work is based on a concept initially developed for future germanium-based neutrinoless double-beta decay experiments.

  16. Suppression of the centrifugal barrier effects in the off-energy-shell neutron+$^{17}$O interaction

    E-Print Network [OSTI]

    M. Gulino; C. Spitaleri; X. D. Tang; G. L. Guardo; L. Lamia; S. Cherubini; B. Bucher; V. Burjan; M. Couder; P. Davies; R. deBoer; X. Fang; V. Z. Goldberg; Z. Hons; V. Kroha; L. Lamm; M. La Cognata; C. Li; C. Ma; J. Mrazek; A. M. Mukhamedzhanov; M. Notani; S. OBrien; R. G. Pizzone; G. G. Rapisarda; D. Roberson; M. L. Sergi; W. Tan; I. . J. Thompson; M. Wiescher

    2012-12-11T23:59:59.000Z

    The reaction $^{17}$O($n,\\alpha$)$^{14}$C was studied at energies from $E_{cm}=0$ to $E_{cm}=350$ keV using the quasi-free deuteron break-up in the three body reaction $^{17}$O$+d \\rightarrow \\alpha+ ^{14}$C$+p$, extending the Trojan Horse indirect method (THM) to neutron-induced reactions. It is found that the $^{18}$O excited state at $E^*=8.125 \\pm 0.002$ MeV observed in THM experiments is absent in the direct measurement because of its high centrifugal barrier. The angular distributions of the populated resonances have been measured for the first time. The results unambiguously indicate the ability of the THM to overcome the centrifugal barrier suppression effect and to pick out the contribution of the bare nuclear interaction.

  17. Enhancement and suppression of opto-acoustic parametric interactions using optical feedback

    SciTech Connect (OSTI)

    Zhang Zhongyang; Zhao Chunnong; Ju, L.; Blair, D. G. [School of Physics, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009 (Australia)

    2010-01-15T23:59:59.000Z

    A three mode opto-acoustic parametric amplifier (OAPA) is created when two orthogonal optical modes in a high finesse optical cavity are coupled via an acoustic mode of the cavity mirror. Such interactions are predicted to occur in advanced long baseline gravitational wave detectors. They can have high positive gain, which leads to strong parametric instability. Here we show that an optical feedback scheme can enhance or suppress the parametric gain of an OAPA, allowing exploration of three-mode parametric interactions, especially in cavity systems that have insufficient optical power to achieve spontaneous instability. We derive analytical equations and show that optical feedback is capable of controlling predicted instabilities in advanced gravitational wave detectors within a time scale of 13approx10 s.

  18. Investigation of the suppression effect of polyethylene glycol on copper electroplating by electrochemical impedance spectroscopy

    SciTech Connect (OSTI)

    Hung, C.-C.; Lee, W.-H.; Wang, Y.-L.; Chan, D.-Y.; Hwang, G.-J. [Department of Electrical Engineering, National Cheng Kung University, Tainan 701, Taiwan (China); Department of Electrical Engineering, National Chiayi University, Chiayi, Taiwan (China); College of Science and Engineering, National University of Tainan, Tainan 700, Taiwan (China)

    2008-09-15T23:59:59.000Z

    Polyethylene glycol (PEG) is an additive that is commonly used as a suppressor in the semiconductor copper (Cu)-electroplating process. In this study, electrochemical impedance spectroscopy (EIS) was used to analyze the electrochemical behavior of PEG in the Cu-electroplating process. Polarization analysis, cyclic-voltammetry stripping, and cell voltage versus plating time were examined to clarify the suppression behavior of PEG. The equivalent circuit simulated from the EIS data shows that PEG inhibited the Cu-electroplating rate by increasing the charge-transfer resistance as well as the resistance of the adsorption layer. The presence of a large inductance demonstrated the strong adsorption of cuprous-PEG-chloride complexes on the Cu surface during the Cu-electroplating process. Increasing the PEG concentration appears to increase the resistances of charge transfer, the adsorption layer, and the inductance of the electroplating system.

  19. Apparatus for suppressing formation of vortices in the coolant fluid of a nuclear reactor and associated method

    DOE Patents [OSTI]

    Ekeroth, Douglas E. (Delmont, PA); Garner, Daniel C. (Murrysville, PA); Hopkins, Ronald J. (Pensacola, FL); Land, John T. (Pensacola, FL)

    1993-01-01T23:59:59.000Z

    An apparatus and method are provided for suppressing the formation of vortices in circulating coolant fluid of a nuclear reactor. A vortex-suppressing plate having a plurality of openings therein is suspended within the lower plenum of a reactor vessel below and generally parallel to the main core support of the reactor. The plate is positioned so as to intersect vortices which may form in the circulating reactor coolant fluid. The intersection of the plate with such vortices disrupts the rotational flow pattern of the vortices, thereby disrupting the formation thereof.

  20. Apparatus for suppressing formation of vortices in the coolant fluid of a nuclear reactor and associated method

    DOE Patents [OSTI]

    Ekeroth, D.E.; Garner, D.C.; Hopkins, R.J.; Land, J.T.

    1993-11-30T23:59:59.000Z

    An apparatus and method are provided for suppressing the formation of vortices in circulating coolant fluid of a nuclear reactor. A vortex-suppressing plate having a plurality of openings therein is suspended within the lower plenum of a reactor vessel below and generally parallel to the main core support of the reactor. The plate is positioned so as to intersect vortices which may form in the circulating reactor coolant fluid. The intersection of the plate with such vortices disrupts the rotational flow pattern of the vortices, thereby disrupting the formation thereof. 3 figures.

  1. Eckol suppresses maintenance of stemness and malignancies in glioma stem-like cells

    SciTech Connect (OSTI)

    Hyun, Kyung-Hwan; Yoon, Chang-Hwan; Kim, Rae-Kwon; Lim, Eun-Jung [Department of Chemistry, Research Institute for Natural Sciences, Hanyang University, Seoul 133-791 (Korea, Republic of); An, Sungkwan [Functional Genoproteome Research Centre, Konkuk University, Seoul 143-701 (Korea, Republic of); Park, Myung-Jin [Division of Radiation Cancer Biology, Korea Institute of Radiological and Medical Sciences, Seoul 139-706 (Korea, Republic of); Hyun, Jin-Won [College of Medicine and Applied Radiological Science Research Institute, Jeju National University, Jeju-si 690-756 (Korea, Republic of); Suh, Yongjoon [Department of Chemistry, Research Institute for Natural Sciences, Hanyang University, Seoul 133-791 (Korea, Republic of); Kim, Min-Jung, E-mail: kimmj74@hanyang.ac.kr [Department of Chemistry, Research Institute for Natural Sciences, Hanyang University, Seoul 133-791 (Korea, Republic of); Lee, Su-Jae, E-mail: sj0420@hanyang.ac.kr [Department of Chemistry, Research Institute for Natural Sciences, Hanyang University, Seoul 133-791 (Korea, Republic of)

    2011-07-01T23:59:59.000Z

    A subpopulation of cancer cells with stem cell properties is responsible for tumor maintenance and progression, and may contribute to resistance to anticancer treatments. Thus, compounds that target cancer stem-like cells could be usefully applied to destroy cancer. In this study, we investigated the effect of Eckol, a phlorotannin compound, on stemness and malignancies in glioma stem-like cells. To determine whether Eckol targets glioma stem-like cells, we examined whether Eckol treatment could change the expression levels of glioma stem-like cell markers and self-renewal-related proteins as well as the sphere forming ability, and the sensitivity to anticancer treatments. Alterations in the malignant properties of sphere-derived cells by Eckol were also investigated by soft-agar colony forming assay, by xenograft assay in nude mice, and by cell invasion assay. Treatment of sphere-forming glioma cells with Eckol effectively decreased the sphere formation as well as the CD133{sup +} cell population. Eckol treatment suppressed expression of the glioma stem-like cell markers and the self-renewal-related proteins without cell death. Moreover, treatment of glioma stem-like cells with Eckol significantly attenuated anchorage-independent growth on soft agar and tumor formation in xenograft mice. Importantly, Eckol treatment effectively reduced the resistance of glioma stem-like cells to ionizing radiation and temozolomide. Treatment of glioma stem-like cells with Eckol markedly blocked both phosphoinositide 3-kinase-Akt and Ras-Raf-1-Erk signaling pathways. These results indicate that the natural phlorotannin Eckol suppresses stemness and malignancies in glioma stem-like cells, and thereby makes glioma stem-like cells more sensitive to anticancer treatments, providing novel therapeutic strategies targeting specifically cancer stem-like cells.

  2. Simulation of Thermal Stratification in BWR Suppression Pools with One Dimensional Modeling Method

    SciTech Connect (OSTI)

    Haihua Zhao; Ling Zou; Hongbin Zhang

    2014-01-01T23:59:59.000Z

    The suppression pool in a boiling water reactor (BWR) plant not only is the major heat sink within the containment system, but also provides the major emergency cooling water for the reactor core. In several accident scenarios, such as a loss-of-coolant accident and extended station blackout, thermal stratification tends to form in the pool after the initial rapid venting stage. Accurately predicting the pool stratification phenomenon is important because it affects the peak containment pressure; the pool temperature distribution also affects the NPSHa (available net positive suction head) and therefore the performance of the Emergency Core Cooling System and Reactor Core Isolation Cooling System pumps that draw cooling water back to the core. Current safety analysis codes use zero dimensional (0-D) lumped parameter models to calculate the energy and mass balance in the pool; therefore, they have large uncertainties in the prediction of scenarios in which stratification and mixing are important. While three-dimensional (3-D) computational fluid dynamics (CFD) methods can be used to analyze realistic 3-D configurations, these methods normally require very fine grid resolution to resolve thin substructures such as jets and wall boundaries, resulting in a long simulation time. For mixing in stably stratified large enclosures, the BMIX++ code (Berkeley mechanistic MIXing code in C++) has been developed to implement a highly efficient analysis method for stratification where the ambient fluid volume is represented by one-dimensional (1-D) transient partial differential equations and substructures (such as free or wall jets) are modeled with 1-D integral models. This allows very large reductions in computational effort compared to multi-dimensional CFD modeling. One heat-up experiment performed at the Finland POOLEX facility, which was designed to study phenomena relevant to Nordic design BWR suppression pool including thermal stratification and mixing, is used for validation. Comparisons between the BMIX++, GOTHIC, and CFD calculations against the POOLEX experimental data are discussed in detail.

  3. Deconfinement as an entropic self-destruction: a solution for the quarkonium suppression puzzle?

    SciTech Connect (OSTI)

    Kharzeev, Dmitri E. [Stony Brook Univ, Department of Physics and Astronomy, NY (United States); Brookhaven National Laboratory, Department of Physics, Upton, NY (United States)

    2014-10-01T23:59:59.000Z

    The entropic approach to dissociation of bound states immersed in strongly coupled systems is developed. In such systems, the excitations of the bound state are often delocalized and characterized by a large entropy, so that the bound state is strongly entangled with the rest of the statistical system. If this entropy S increases with the separation r between the constituents of the bound state, S=S(r), then the resulting entropic force F=T ?S/?r (T is temperature) can drive the dissociation process. As a specific example, we consider the case of heavy quarkonium in strongly coupled quark-gluon plasma, where lattice QCD indicates a large amount of entropy associated with the heavy quark pair at temperatures 0.9Tc?T?1.5Tc (Tc is the deconfinement temperature); this entropy S(r) grows with the interquark distance r. We argue that the entropic mechanism results in an anomalously strong quarkonium suppression in the temperature range near Tc. This entropic self-destruction may thus explain why the experimentally measured quarkonium nuclear modification factor at RHIC (lower energy density) is smaller than at LHC (higher energy density), possibly resolving the “quarkonium suppression puzzle”—all of the previously known mechanisms of quarkonium dissociation operate more effectively at higher energy densities, and this contradicts the data. Moreover, we find that near Tc the entropic force leads to delocalization of the bound hadron states; we argue that this delocalization may be the mechanism underlying deconfinement.

  4. Noise suppression in reconstruction of low-Z target megavoltage cone-beam CT images

    SciTech Connect (OSTI)

    Wang Jing; Robar, James; Guan Huaiqun [Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas 75235 (United States); Departments of Radiation Oncology and Physics and Atmospheric Science, Dalhousie University, Halifax, Nova Scotia, B3H1V7 (Canada); Department of Radiation Oncology, Saint Vincent Hospital, Worcester, Massachusetts 01608 (United States)

    2012-08-15T23:59:59.000Z

    Purpose: To improve the image contrast-to-noise (CNR) ratio for low-Z target megavoltage cone-beam CT (MV CBCT) using a statistical projection noise suppression algorithm based on the penalized weighted least-squares (PWLS) criterion. Methods: Projection images of a contrast phantom, a CatPhan{sup Registered-Sign} 600 phantom and a head phantom were acquired by a Varian 2100EX LINAC with a low-Z (Al) target and low energy x-ray beam (2.5 MeV) at a low-dose level and at a high-dose level. The projections were then processed by minimizing the PWLS objective function. The weighted least square (WLS) term models the noise of measured projection and the penalty term enforces the smoothing constraints of the projection image. The variance of projection data was chosen as the weight for the PWLS objective function and it determined the contribution of each measurement. An anisotropic quadratic form penalty that incorporates the gradient information of projection image was used to preserve edges during noise reduction. Low-Z target MV CBCT images were reconstructed by the FDK algorithm after each projection was processed by the PWLS smoothing. Results: Noise in low-Z target MV CBCT images were greatly suppressed after the PWLS projection smoothing, without noticeable sacrifice of the spatial resolution. Depending on the choice of smoothing parameter, the CNR of selected regions of interest in the PWLS processed low-dose low-Z target MV CBCT image can be higher than the corresponding high-dose image.Conclusion: The CNR of low-Z target MV CBCT images was substantially improved by using PWLS projection smoothing. The PWLS projection smoothing algorithm allows the reconstruction of high contrast low-Z target MV CBCT image with a total dose of as low as 2.3 cGy.

  5. An efficient modeling method for thermal stratification simulation in a BWR suppression pool

    SciTech Connect (OSTI)

    Haihua Zhao; Ling Zou; Hongbin Zhang; Hua Li; Walter Villanueva; Pavel Kudinov

    2012-09-01T23:59:59.000Z

    The suppression pool in a BWR plant not only is the major heat sink within the containment system, but also provides major emergency cooling water for the reactor core. In several accident scenarios, such as LOCA and extended station blackout, thermal stratification tends to form in the pool after the initial rapid venting stage. Accurately predicting the pool stratification phenomenon is important because it affects the peak containment pressure; and the pool temperature distribution also affects the NPSHa (Available Net Positive Suction Head) and therefore the performance of the pump which draws cooling water back to the core. Current safety analysis codes use 0-D lumped parameter methods to calculate the energy and mass balance in the pool and therefore have large uncertainty in prediction of scenarios in which stratification and mixing are important. While 3-D CFD methods can be used to analyze realistic 3D configurations, these methods normally require very fine grid resolution to resolve thin substructures such as jets and wall boundaries, therefore long simulation time. For mixing in stably stratified large enclosures, the BMIX++ code has been developed to implement a highly efficient analysis method for stratification where the ambient fluid volume is represented by 1-D transient partial differential equations and substructures such as free or wall jets are modeled with 1-D integral models. This allows very large reductions in computational effort compared to 3-D CFD modeling. The POOLEX experiments at Finland, which was designed to study phenomena relevant to Nordic design BWR suppression pool including thermal stratification and mixing, are used for validation. GOTHIC lumped parameter models are used to obtain boundary conditions for BMIX++ code and CFD simulations. Comparison between the BMIX++, GOTHIC, and CFD calculations against the POOLEX experimental data is discussed in detail.

  6. Fractal-Shape 40 GHz Microstrip Bandpass Filter on High-Resistivity Si for Suppression of the 2nd

    E-Print Network [OSTI]

    Tentzeris, Manos

    Fractal-Shape 40 GHz Microstrip Bandpass Filter on High-Resistivity Si for Suppression of the 2nd, the Koch fractal shape is applied for the first time to microstrip bandpass filters integrated on a high. To reduce the silicon substrate loss, high resistivity silicon (HRS) can be used. Several fractal geometries

  7. Polyunsaturated Fatty Acid Suppression of Hepatic Fatty Acid Synthase and S14 Gene Expression Does Not Require Peroxisome

    E-Print Network [OSTI]

    Omiecinski, Curtis

    of genes encoding fatty acid synthase, stearoyl-CoA desaturase, the S14 protein, and L-type pyruvate kinasePolyunsaturated Fatty Acid Suppression of Hepatic Fatty Acid Synthase and S14 Gene Expression Does, Maryland 20892 Dietary polyunsaturated fatty acids (PUFA) induce hepatic peroxisomal and microsomal fatty

  8. Wildfire Suppression Equipment Engines CSFS has placed 140 federal excess property vehicles located throughout the state. Our

    E-Print Network [OSTI]

    Wildfire Suppression Equipment Engines ­ CSFS has placed 140 federal excess property vehicles fire engines and provides all major maintenance. The all-wheel drive (4x4 and 6x6) engines are equipped equipment such as hose, nozzles, and hand tools. These engines are inspected annually and updated

  9. Hyaluronan suppresses prostate tumor cell proliferation through diminished expression of N-cadherin and aberrant growth factor receptor signaling

    SciTech Connect (OSTI)

    Bharadwaj, Alamelu G.; Goodrich, Nathaniel P.; McAtee, Caitlin O.; Haferbier, Katie [Department of Biochemistry, University of Nebraska, Lincoln, NE 68588 (United States)] [Department of Biochemistry, University of Nebraska, Lincoln, NE 68588 (United States); Oakley, Gregory G.; Wahl, James K. [Department of Oral Biology, University of Nebraska College of Dentistry, Lincoln, NE 68588 (United States)] [Department of Oral Biology, University of Nebraska College of Dentistry, Lincoln, NE 68588 (United States); Simpson, Melanie A., E-mail: msimpson2@unl.edu [Department of Biochemistry, University of Nebraska, Lincoln, NE 68588 (United States); Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198 (United States)

    2011-05-01T23:59:59.000Z

    Hyaluronan (HA) production has been functionally implicated in prostate tumorigenesis and metastasis. We previously used prostate tumor cells overexpressing the HA synthesizing enzyme HAS3 or the clinically relevant hyaluronidase Hyal1 to show that excess HA production suppresses tumor growth, while HA turnover accelerates spontaneous metastasis from the prostate. Here, we examined pathways responsible for effects of HAS3 and Hyal1 on tumor cell phenotype. Detailed characterization of cell cycle progression revealed that expression of Hyal1 accelerated cell cycle re-entry following synchronization, whereas HAS3 alone delayed entry. Hyal1 expressing cells exhibited a significant reduction in their ability to sustain ERK phosphorylation upon stimulation by growth factors, and in their expression of the cyclin-dependent kinase inhibitor p21. In contrast, HAS3 expressing cells showed prolonged ERK phosphorylation and increased expression of both p21 and p27, in asynchronous and synchronized cultures. Changes in cell cycle regulatory proteins were accompanied by HA-induced suppression of N-cadherin, while E-cadherin expression and {beta}-catenin expression and distribution remained unchanged. Our results are consistent with a model in which excess HA synthesis suppresses cell proliferation by promoting homotypic E-cadherin mediated cell-cell adhesion, consequently signaling to elevate cell cycle inhibitor expression and suppress G1- to S-phase transition.

  10. NONLINEAR EFFECTS OF A MODAL DOMAIN OPTICAL FIBER SENSOR IN A VIBRATION SUPPRESSION CONTROL LOOP FOR A FLEXIBLE

    E-Print Network [OSTI]

    Lindner, Douglas K.

    NONLINEAR EFFECTS OF A MODAL DOMAIN OPTICAL FIBER SENSOR IN A VIBRATION SUPPRESSION CONTROL LOOP Recently, a modal domain optical fiber sensor has been demonstrated as a sensor in a control system the region of linear operation in terms of the optical fiber sensor parameters. #12;2 1. INTRODUCTION

  11. Plant foliar disease suppression mediated by composted forms of paper mill residuals exhibits molecular features of induced resistance

    E-Print Network [OSTI]

    Goodman, Robert M.

    Plant foliar disease suppression mediated by composted forms of paper mill residuals exhibits Arabidopsis thaliana grown in soil from field plots amended with composted forms of paper mill residuals (PMR with plants grown in soil from field plots amended with a non-composted PMR or non-amended soils. Similar

  12. Overexpressed of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability

    SciTech Connect (OSTI)

    Schild, David; Wiese, Claudia

    2009-10-15T23:59:59.000Z

    RAD51, a key protein in the homologous recombinational DNA repair (HRR) pathway, is the major strand-transferase required for mitotic recombination. An important early step in HRR is the formation of single-stranded DNA (ss-DNA) coated by RPA (a ss-DNA binding protein). Displacement of RPA by RAD51 is highly regulated and facilitated by a number of different proteins known as the 'recombination mediators'. To assist these recombination mediators, a second group of proteins also is required and we are defining these proteins here as 'recombination co-mediators'. Defects in either recombination mediators or comediators, including BRCA1 and BRCA2, lead to impaired HRR that can genetically be complemented for (i.e. suppressed) by overexpression of RAD51. Defects in HRR have long been known to contribute to genomic instability leading to tumor development. Since genomic instability also slows cell growth, precancerous cells presumably require genomic restabilization to gain a growth advantage. RAD51 is overexpressed in many tumors, and therefore, we hypothesize that the complementing ability of elevated levels of RAD51 in tumors with initial HRR defects limits genomic instability during carcinogenic progression. Of particular interest, this model may also help explain the high frequency of TP53 mutations in human cancers, since wild-type p53 represses RAD51.

  13. Wide angle Compton scattering on the proton: study of power suppressed corrections

    E-Print Network [OSTI]

    N. Kivel; M. Vanderhaeghen

    2015-04-04T23:59:59.000Z

    We study the wide angle Compton scattering process on a proton within the soft collinear factorization (SCET) framework. The main purpose of this work is to estimate the effect due to certain power suppressed corrections. We consider all possible kinematical power corrections and also include the subleading amplitudes describing the scattering with nucleon helicity flip. Under certain assumptions we present a leading-order factorization formula for these amplitudes which includes the hard- and soft-spectator contributions. We apply the formalism and perform a phenomenological analysis of the cross section and asymmetries in the wide angle Compton scattering on a proton. We assume that in the relevant kinematical region where $-t,-u>2.5$~GeV$^{2}$ the dominant contribution is provided by the soft-spectator mechanism. The hard coefficient functions of the corresponding SCET operators are taken in the leading-order approximation. The analysis of existing cross section data shows that the contribution of the helicity flip amplitudes to this observable is quite small and comparable with other expected theoretical uncertainties. We also show predictions for double polarization observables for which experimental information exists.

  14. Suppression of renal fibrosis by galectin-1 in high glucose-treated renal epithelial cells

    SciTech Connect (OSTI)

    Okano, Kazuhiro, E-mail: kaokano@kc.twmu.ac.jp; Tsuruta, Yuki; Yamashita, Tetsuri; Takano, Mari; Echida, Yoshihisa; Nitta, Kosaku

    2010-11-15T23:59:59.000Z

    Diabetic nephropathy is the most common cause of chronic kidney disease. We investigated the ability of intracellular galectin-1 (Gal-1), a prototype of endogenous lectin, to prevent renal fibrosis by regulating cell signaling under a high glucose (HG) condition. We demonstrated that overexpression of Gal-1 reduces type I collagen (COL1) expression and transcription in human renal epithelial cells under HG conditions and transforming growth factor-{beta}1 (TGF-{beta}1) stimulation. Matrix metalloproteinase 1 (MMP1) is stimulated by Gal-1. HG conditions and TGF-{beta}1 treatment augment expression and nuclear translocation of Gal-1. In contrast, targeted inhibition of Gal-1 expression reduces COL1 expression and increases MMP1 expression. The Smad3 signaling pathway is inhibited, whereas two mitogen-activated protein kinase (MAPK) pathways, p38 and extracellular signal-regulated kinase (ERK), are activated by Gal-1, indicating that Gal-1 regulates these signaling pathways in COL1 production. Using specific inhibitors of Smad3, ERK, and p38 MAPK, we showed that ERK MAPK activated by Gal-1 plays an inhibitory role in COL1 transcription and that activation of the p38 MAPK pathway by Gal-1 plays a negative role in MMP1 production. Taken together, two MAPK pathways are stimulated by increasing levels of Gal-1 in the HG condition, leading to suppression of COL1 expression and increase of MMP1 expression.

  15. Norathyriol Suppresses Skin Cancers Induced by Solar Ultraviolet Radiation by Targeting ERK Kinases

    SciTech Connect (OSTI)

    Li, Jixia; Malakhova, Margarita; Mottamal, Madhusoodanan; Reddy, Kanamata; Kurinov, Igor; Carper, Andria; Langfald, Alyssa; Oi, Naomi; Kim, Myoung Ok; Zhu, Feng; Sosa, Carlos P.; Zhou, Keyuan; Bode, Ann M.; Dong, Zigang (Cornell); (Guangdong); (UMM)

    2012-06-27T23:59:59.000Z

    Ultraviolet (UV) irradiation is the leading factor in the development of skin cancer, prompting great interest in chemopreventive agents for this disease. In this study, we report the discovery of norathyriol, a plant-derived chemopreventive compound identified through an in silico virtual screening of the Chinese Medicine Library. Norathyriol is a metabolite of mangiferin found in mango, Hypericum elegans, and Tripterospermum lanceolatum and is known to have anticancer activity. Mechanistic investigations determined that norathyriol acted as an inhibitor of extracellular signal-regulated kinase (ERK)1/2 activity to attenuate UVB-induced phosphorylation in mitogen-activated protein kinases signaling cascades. We confirmed the direct and specific binding of norathyriol with ERK2 through a cocrystal structural analysis. The xanthone moiety in norathyriol acted as an adenine mimetic to anchor the compound by hydrogen bonds to the hinge region of the protein ATP-binding site on ERK2. Norathyriol inhibited in vitro cell growth in mouse skin epidermal JB6 P+ cells at the level of G{sub 2}-M phase arrest. In mouse skin tumorigenesis assays, norathyriol significantly suppressed solar UV-induced skin carcinogenesis. Further analysis indicated that norathyriol mediates its chemopreventive activity by inhibiting the ERK-dependent activity of transcriptional factors AP-1 and NF-{kappa}B during UV-induced skin carcinogenesis. Taken together, our results identify norathyriol as a safe new chemopreventive agent that is highly effective against development of UV-induced skin cancer.

  16. Suppressing light reflection from polycrystalline silicon thin films through surface texturing and silver nanostructures

    SciTech Connect (OSTI)

    Akhter, Perveen [Department of Physics, University at Albany-SUNY, Albany, New York 12222 (United States); Huang, Mengbing, E-mail: mhuang@albany.edu; Kadakia, Nirag; Spratt, William; Malladi, Girish; Bakhru, Hassarum [SUNY College of Nanoscale Science and Engineering, Albany, New York 12203 (United States)

    2014-09-21T23:59:59.000Z

    This work demonstrates a novel method combining ion implantation and silver nanostructures for suppressing light reflection from polycrystalline silicon thin films. Samples were implanted with 20-keV hydrogen ions to a dose of 10{sup 17}/cm{sup 2}, and some of them received an additional argon ion implant to a dose of 5?×?10{sup 15} /cm{sup 2} at an energy between 30 and 300?keV. Compared to the case with a single H implant, the processing involved both H and Ar implants and post-implantation annealing has created a much higher degree of surface texturing, leading to a more dramatic reduction of light reflection from polycrystalline Si films over a broadband range between 300 and 1200?nm, e.g., optical reflection from the air/Si interface in the AM1.5 sunlight condition decreasing from ?30% with an untextured surface to below 5% for a highly textured surface after post-implantation annealing at 1000?°C. Formation of Ag nanostructures on these ion beam processed surfaces further reduces light reflection, and surface texturing is expected to have the benefit of diminishing light absorption losses within large-size (>100?nm) Ag nanoparticles, yielding an increased light trapping efficiency within Si as opposed to the case with Ag nanostructures on a smooth surface. A discussion of the effects of surface textures and Ag nanoparticles on light trapping within Si thin films is also presented with the aid of computer simulations.

  17. Environmental factors affecting long-term stabilization of radon suppression covers for uranium mill tailings

    SciTech Connect (OSTI)

    Young, J.K.; Long, L.W.; Reis, J.W.

    1982-04-01T23:59:59.000Z

    Pacific Northwest Laboratory is investigating the use of a rock armoring blanket (riprap) to mitigate wind and water erosion of an earthen radon suppression cover applied to uranium mill tailings. To help determine design stresses for the tailings piles, environmental parameters are characterized for the five active uranium-producing regions on a site-specific basis. Only conventional uranium mills that are currently operating or that are scheduled to open in the mid 1980s are considered. Available data indicate that flooding has the most potential for disrupting a tailings pile. The arid regions of the Wyoming Basins and the Colorado Plateau are subject to brief storms of high intensity. The Texas Gulf Coast has the highest potential for extreme precipitation from hurricane-related storms. Wind data indicate average wind speeds from 3 to 6 m/sec for the sites, but extremes of 40 m/sec can be expected. Tornado risks range from low to moderate. The Colorado Plateau has the highest seismic potential, with maximum acceleration caused by earthquakes ranging from 0.2 to 0.4 g. Any direct effect from volcanic eruption is negligible, as all mills are located 90 km or more from an igneous or hydrothermal system.

  18. SPARC-90: A code for calculating fission product capture in suppression pools

    SciTech Connect (OSTI)

    Owczarski, P.C.; Burk, K.W. (Pacific Northwest Lab., Richland, WA (United States))

    1991-10-01T23:59:59.000Z

    This report describes the technical bases and use of two updated versions of a computer code initially developed to serve as a tool for calculating aerosol particle retention in boiling water reactor (BWR) pressure suppression pools during severe accidents, SPARC-87 and SPARC-90. The most recent version is SPARC-90. The initial or prototype version (Owczarski, Postma, and Schreck 1985) was improved to include the following: rigorous treatment of local particle deposition velocities on the surface of oblate spherical bubbles, new correlations for hydrodynamic behavior of bubble swarms, models for aerosol particle growth, both mechanistic and empirical models for vent exit region scrubbing, specific models for hydrodynamics of bubble breakup at various vent types, and models for capture of vapor iodine species. A complete user's guide is provided for SPARC-90 (along with SPARC-87). A code description, code operating instructions, partial code listing, examples of the use of SPARC-90, and summaries of experimental data comparison studies also support the use of SPARC-90. 29 refs., 4 figs., 11 tabs.

  19. Methods And System Suppressing Clutter In A Gain-Block, Radar-Responsive Tag System

    DOE Patents [OSTI]

    Ormesher, Richard C. (Albuquerque, NM); Axline, Robert M. (Albuquerque, NM)

    2006-04-18T23:59:59.000Z

    Methods and systems reduce clutter interference in a radar-responsive tag system. A radar transmits a series of linear-frequency-modulated pulses and receives echo pulses from nearby terrain and from radar-responsive tags that may be in the imaged scene. Tags in the vicinity of the radar are activated by the radar's pulses. The tags receive and remodulate the radar pulses. Tag processing reverses the direction, in time, of the received waveform's linear frequency modulation. The tag retransmits the remodulated pulses. The radar uses a reversed-chirp de-ramp pulse to process the tag's echo. The invention applies to radar systems compatible with coherent gain-block tags. The invention provides a marked reduction in the strength of residual clutter echoes on each and every echo pulse received by the radar. SAR receiver processing effectively whitens passive-clutter signatures across the range dimension. Clutter suppression of approximately 14 dB is achievable for a typical radar system.

  20. Nanoscale strain-induced pair suppression as a vortex-pinning mechanism in high- temperature superconductors

    SciTech Connect (OSTI)

    Llordes, Anna [ICMAB, Barcelona, Spain; Palau, A. [ICMAB, Barcelona, Spain; Gazquez, J. [Oak Ridge National Laboratory (ORNL); Coll, M. [ICMAB, Barcelona, Spain; Vlad, R. [ICMAB, Barcelona, Spain; Pomar, A. [ICMAB, Barcelona, Spain; Arbiol, Jordi [ICMAB, Barcelona, Spain; Guzman, Roger [ICMAB, Barcelona, Spain; Ye, S. [ICMAB, Barcelona, Spain; Rouco, V [ICMAB, Barcelona, Spain; Sandiumenge, Felip [ICMAB, Barcelona, Spain; Ricart, Susagna [ICMAB, Barcelona, Spain; Puig, Teresa [ICMAB, Barcelona, Spain; Varela del Arco, Maria [ORNL; Chataigner, D. [CRISMAT, Caen, France; Vanacken, J. [INPAC-Institute for Nanoscale Physics and Chemistry, Leuven, Belgium; Gutierrez, J. [INPAC-Institute for Nanoscale Physics and Chemistry, Leuven, Belgium; Moschalkov, V. [INPAC-Institute for Nanoscale Physics and Chemistry, Leuven, Belgium; Deutscher, G. [Tel Aviv University; Magen Dominguez, Cesar [ORNL; Obradors, Xavier [ICMAB, Barcelona, Spain

    2012-01-01T23:59:59.000Z

    Boosting large-scale superconductor applications require nanostructured conductors with artificial pinning centres immobilizing quantized vortices at high temperature and magnetic fields. Here we demonstrate a highly effective mechanism of artificial pinning centers in solution-derived high-temperature superconductor nanocomposites through generation of nanostrained regions where Cooper pair formation is suppressed. The nanostrained regions identified from transmission electron microscopy devise a very high concentration of partial dislocations associated with intergrowths generated between the randomly oriented nanodots and the epitaxial YBa{sub 2}Cu{sub 3}O{sub 7} matrix. Consequently, an outstanding vortex-pinning enhancement correlated to the nanostrain is demonstrated for four types of randomly oriented nanodot, and a unique evolution towards an isotropic vortex-pinning behaviour, even in the effective anisotropy, is achieved as the nanostrain turns isotropic. We suggest a new vortex-pinning mechanism based on the bond-contraction pairing model, where pair formation is quenched under tensile strain, forming new and effective core-pinning regions.

  1. Study of the near-threshold ? ? mass enhancement in doubly OZI-suppressed J / ? ? ? ? ? decays

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Ablikim, M.; Achasov, M. N.; Albayrak, O.; Ambrose, D. J.; An, F. F.; An, Q.; Bai, J. Z.; Ban, Y.; Becker, J.; Bennett, J. V.; Bertani, M.; Bian, J. M.; Boger, E.; Bondarenko, O.; Boyko, I.; Briere, R. A.; Bytev, V.; Cai, X.; Cakir, O.; Calcaterra, A.; Cao, G. F.; Cetin, S. A.; Chang, J. F.; Chelkov, G.; Chen, G.; Chen, H. S.; Chen, J. C.; Chen, M. L.; Chen, S. J.; Chen, X.; Chen, Y. B.; Cheng, H. P.; Chu, Y. P.; Cronin-Hennessy, D.; Dai, H. L.; Dai, J. P.; Dedovich, D.; Deng, Z. Y.; Denig, A.; Denysenko, I.; Destefanis, M.; Ding, W. M.; Ding, Y.; Dong, L. Y.; Dong, M. Y.; Du, S. X.; Fang, J.; Fang, S. S.; Fava, L.; Feng, C. Q.; Ferroli, R. B.; Friedel, P.; Fu, C. D.; Gao, Y.; Geng, C.; Goetzen, K.; Gong, W. X.; Gradl, W.; Greco, M.; Gu, M. H.; Gu, Y. T.; Guan, Y. H.; Guo, A. Q.; Guo, L. B.; Guo, T.; Guo, Y. P.; Han, Y. L.; Harris, F. A.; He, K. L.; He, M.; He, Z. Y.; Held, T.; Heng, Y. K.; Hou, Z. L.; Hu, C.; Hu, H. M.; Hu, J. F.; Hu, T.; Huang, G. M.; Huang, G. S.; Huang, J. S.; Huang, L.; Huang, X. T.; Huang, Y.; Huang, Y. P.; Hussain, T.; Ji, C. S.; Ji, Q.; Ji, Q. P.; Ji, X. B.; Ji, X. L.; Jiang, L. L.; Jiang, X. S.; Jiao, J. B.; Jiao, Z.; Jin, D. P.; Jin, S.; Jing, F. F.; Kalantar-Nayestanaki, N.; Kavatsyuk, M.; Kopf, B.; Kornicer, M.; Kuehn, W.; Lai, W.; Lange, J. S.; Leyhe, M.; Li, C. H.; Li, Cheng; Li, Cui; Li, D. M.; Li, F.; Li, G.; Li, H. B.; Li, J. C.; Li, K.; Li, Lei; Li, Q. J.; Li, S. L.; Li, W. D.; Li, W. G.; Li, X. L.; Li, X. N.; Li, X. Q.; Li, X. R.; Li, Z. B.; Liang, H.; Liang, Y. F.; Liang, Y. T.; Liao, G. R.; Liao, X. T.; Lin, D.; Liu, B. J.; Liu, C. L.; Liu, C. X.; Liu, F. H.; Liu, Fang; Liu, Feng; Liu, H.; Liu, H. B.; Liu, H. H.; Liu, H. M.; Liu, H. W.; Liu, J. P.; Liu, K.; Liu, K. Y.; Liu, Kai; Liu, P. L.; Liu, Q.; Liu, S. B.; Liu, X.; Liu, Y. B.; Liu, Z. A.; Liu, Zhiqiang; Liu, Zhiqing; Loehner, H.; Lu, G. R.; Lu, H. J.; Lu, J. G.; Lu, Q. W.; Lu, X. R.; Lu, Y. P.; Luo, C. L.; Luo, M. X.; Luo, T.; Luo, X. L.; Lv, M.; Ma, C. L.; Ma, F. C.; Ma, H. L.; Ma, Q. M.; Ma, S.; Ma, T.; Ma, X. Y.; Maas, F. E.; Maggiora, M.; Malik, Q. A.; Mao, Y. J.; Mao, Z. P.; Messchendorp, J. G.; Min, J.; Min, T. J.; Mitchell, R. E.; Mo, X. H.; Morales Morales, C.; Muchnoi, N. Yu.; Muramatsu, H.; Nefedov, Y.; Nicholson, C.; Nikolaev, I. B.; Ning, Z.; Olsen, S. L.; Ouyang, Q.; Pacetti, S.; Park, J. W.; Pelizaeus, M.; Peng, H. P.; Peters, K.; Ping, J. L.; Ping, R. G.; Poling, R.; Prencipe, E.; Qi, M.; Qian, S.; Qiao, C. F.; Qin, L. Q.; Qin, X. S.; Qin, Y.; Qin, Z. H.; Qiu, J. F.; Rashid, K. H.; Rong, G.; Ruan, X. D.; Sarantsev, A.; Schaefer, B. D.; Shao, M.; Shen, C. P.; Shen, X. Y.; Sheng, H. Y.; Shepherd, M. R.; Song, X. Y.; Spataro, S.; Spruck, B.; Sun, D. H.; Sun, G. X.; Sun, J. F.; Sun, S. S.; Sun, Y. J.; Sun, Y. Z.; Sun, Z. J.; Sun, Z. T.; Tang, C. J.; Tang, X.; Tapan, I.; Thorndike, E. H.; Toth, D.; Ullrich, M.; Varner, G. S.; Wang, B. Q.; Wang, D.; Wang, D. Y.; Wang, K.; Wang, L. L.; Wang, L. S.; Wang, M.; Wang, P.; Wang, P. L.; Wang, Q. J.; Wang, S. G.; Wang, X. F.; Wang, X. L.; Wang, Y. F.; Wang, Z.; Wang, Z. G.; Wang, Z. Y.; Wei, D. H.; Wei, J. B.; Weidenkaff, P.; Wen, Q. G.; Wen, S. P.; Werner, M.; Wiedner, U.; Wu, L. H.; Wu, N.; Wu, S. X.; Wu, W.; Wu, Z.; Xia, L. G.; Xiao, Z. J.; Xie, Y. G.; Xiu, Q. L.; Xu, G. F.; Xu, G. M.; Xu, Q. J.; Xu, Q. N.; Xu, X. P.; Xu, Z. R.; Xue, F.; Xue, Z.; Yan, L.; Yan, W. B.; Yan, Y. H.; Yang, H. X.; Yang, Y.; Yang, Y. X.; Ye, H.; Ye, M.; Ye, M. H.; Yu, B. X.; Yu, C. X.; Yu, H. W.; Yu, J. S.; Yu, S. P.; Yuan, C. Z.; Yuan, Y.; Zafar, A. A.; Zallo, A.; Zeng, Y.; Zhang, B. X.; Zhang, B. Y.; Zhang, C.; Zhang, C. C.; Zhang, D. H.; Zhang, H. H.; Zhang, H. Y.; Zhang, J. Q.; Zhang, J. W.; Zhang, J. Y.; Zhang, J. Z.; Zhang, R.; Zhang, S. H.; Zhang, X. J.; Zhang, X. Y.; Zhang, Y.; Zhang, Y. H.; Zhang, Z. P.; Zhang, Z. Y.; Zhang, Zhenghao; Zhao, G.; Zhao, H. S.; Zhao, J. W.; Zhao, K. X.; Zhao, Lei; Zhao, Ling; Zhao, M. G.; Zhao, Q.; Zhao, Q. Z.; Zhao, S. J.; Zhao, T. C.; Zhao, Y. B.; Zhao, Z. G.; Zhemchugov, A.; Zheng, B.; Zheng, J. P.; Zheng, Y. H.; Zhong, B.; Zhong, Z.; Zhou, L.; Zhou, X. K.; Zhou, X. R.; Zhu, C.; Zhu, K.; Zhu, K. J.; Zhu, S. H.; Zhu, X. L.; Zhu, Y. C.; Zhu, Y. M.; Zhu, Y. S.; Zhu, Z. A.; Zhuang, J.; Zou, B. S.; Zou, J. H.

    2013-02-01T23:59:59.000Z

    A 2.25×10? J/? event sample accumulated with the BESIII detector is used to study the doubly Okubo-Zweig-Iizuka-suppressed decay modes J/?????, ????????, ??K?K?. A strong deviation (>30?) from three-body J/????? phase space is observed near the ?? mass threshold that is consistent with a previous observation reported by the BESII experiment. A partial wave analysis with a tensor covariant amplitude that assumes that the enhancement is due to the presence of a resonance, the X(1810), is performed and confirms that the spin-parity of the X(1810) is 0??. The mass and width of the X(1810) are determined to be M=1795±7(stat)+13-5(syst)±19(mod) MeV/c² and ?=95±10(stat)+21-34(syst)±75(mod) MeV/c², respectively, and the product branching fraction is measured to be B(J/???X(1810))×B(X(1810)???)=(2.00±0.08(stat)+0.45-1.00(syst)±1.30(mod))×10??. These results are consistent within errors with those of the BESII experiment.

  2. Apparatus and method for suppressing vibration and displacement of a bellows

    DOE Patents [OSTI]

    Kuklo, T.C.

    1984-01-01T23:59:59.000Z

    Flexible bellows are utilized between two systems, such as a pumping system and a process station, to partially absorb system vibrations and to compensate for misalignment between the systems. It is common practice to either clamp a rigid spacer between flanges of the two systems to separate them from each other, or to maintain the bellows in unsupported relationship between these systems. In the former bellows arrangement, the rigid spacer transmits vibratory energy between the two systems and the bellows tends to function as an undamped or underdamped unit that resonates at its own frequency to create additional vibratory energy, transmitted to the systems. In the latter, unsupported bellows arrangement, the pressure differential prevalent between the fluid flowing through the bellows and ambient normally causes extension or retraction of the bellows and resulting misalignment problems. The present invention substantially solves the above vibration and misalignment problems by providing an inflatable tube in surrounding relationship about a bellows to suppress vibration and displacement thereof. A method for isolating first and second systems from each other to prevent the transmission of vibratory energy therebetween comprises the steps of attaching at least one flexible bellows between the systems, surrounding the bellows with an inflatable tube, and maintaining a predetermined pressure in the tube to urge the tube in flexible contact with at least some of the convolutions of the bellows.

  3. Background Suppression Using Pulse Shape Analysis with a BEGe Detector for Neutrinoless Double Beta Decay Search with GERDA

    SciTech Connect (OSTI)

    Budjas, Dusan; Schoenert, Stefan [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Chkvorets, Oleg [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Department of Physics, Laurentian University, Ramsey Lake Road, P3E 2C6 Sudbury, Ontario (Canada)

    2009-12-17T23:59:59.000Z

    A pulse shape analysis for distinguishing between double beta decay-like interactions and multiple-scattered photons was performed for the first time using a BEGe-type detector. This discrimination method is included in the research and development for the second phase of the GERDA experiment, since active background suppression techniques are necessary to reach sensitivity for the {sup 76}Ge neutrinoless double beta decay half life of >10{sup 26} years. A suppression of backgrounds in the energy region of interest around the {sup 76}Ge Q{sub {beta}}{sub {beta}} = 2039 keV is demonstrated, with (0.93{+-}0.08)% survival probability for events from {sup 60}Co, (21{+-}3)% for {sup 226}Ra, and (40{+-}2)% for {sup 228}Th. This performance is achieved with (89{+-}1)% acceptance of {sup 228}Th double escape events, which are analogous to double beta decay.

  4. Dorsal eye selector pannier (pnr) suppresses the eye fate to define dorsal margin of the Drosophila eye

    E-Print Network [OSTI]

    Kango-Singh, Madhuri

    Ã?Ã? Ã? Ã?Ã?Ã? Ã? Ã?Ã? Dorsal eye selector pannier (pnr) suppresses the eye fate to define dorsal margin of the Drosophila eye Sarah M. Oros, Meghana Tare, Madhuri Kango-Singh, Amit Singh PII: S0012-1606(10)00975-9 DOI: Oros, Sarah M., Tare, Meghana, Kango-Singh, Madhuri, Singh, Amit, Dorsal eye selector pannier (pnr

  5. 1 Dorsal eye selector pannier (pnr) suppresses the eye fate to define dorsal margin of 2 the Drosophila eye

    E-Print Network [OSTI]

    Singh, Amit

    1 Dorsal eye selector pannier (pnr) suppresses the eye fate to define dorsal margin of 2 the Drosophila eye 3 Sarah M. Oros a,b,1 , Meghana Tare b,1 , Madhuri Kango-Singh a,b,c , Amit Singh a,b,c, 4 xxxx 141516 17 Keywords: 18 Drosophila eye 19 Dorso-ventral eye patterning 20 Pannier 21 GATA-1 22

  6. Search for CP violation in singly Cabibbo suppressed four-body D decays

    SciTech Connect (OSTI)

    Martinelli, Maurizio; /Bari U.

    2011-06-22T23:59:59.000Z

    We search for CP violation in a sample of 4.7 x 10{sup 4} singly Cabibbo suppressed D{sup 0} {yields} K{sup +} K{sup -} {pi}{sup +}{pi}{sup -} decays and 1.8(2.6) x 10{sup 4} D{sub (s)}{sup +} {yields} K{sub S}{sup 0} K{sup +} {pi}{sup +} {pi}{sup -} decays. CP violation is searched for in the difference between the T-odd asymmetries, obtained using triple product correlations, measured for D and {bar D} decays. The measured CP violation parameters are A{sub T}(D{sup 0}) = (1.0 {+-} 5.1(stat) {+-} 4.4(syst)) x 10{sup -3}, A{sub T}(D{sup +}) = (-11.96 {+-} 10.04(stat) {+-} 4.81(syst)) x 10{sup -3} and A{sub T}(D{sub s}{sup +}) = (-13.57 {+-} 7.67(stat) {+-} 4.82(syst)) x 10{sup -3}. This search for CP violation showed that the T-odd correlations are a powerful tool to measure the CP violating observable A{sub T}. The relative simplicity of an analysis based on T-odd correlations and the high quality results that can be obtained, allow to consider this tool as fundamental to search for CP violation in four-body decays. Even if the CP violation has not been found, excluding any New Physics effect to the sensitivity of about 0.5%, it is still worth to search for CP violation in D decays. The high statistics that can be obtained at the LHC or by the proposed high luminosity B-factories, make this topic to be considered in high consideration by experiments such as LHCb, SuperB or SuperBelle. The results outlined in this thesis strongly suggest to include a similar analysis into the Physics program of these experiments.

  7. Inflation that runs naturally: Gravitational waves and suppression of power at large and small scales

    E-Print Network [OSTI]

    Quinn E. Minor; Manoj Kaplinghat

    2015-03-08T23:59:59.000Z

    We point out three correlated predictions of the axion monodromy inflation model: large amplitude of gravitational waves, suppression of power on horizon scales and on scales relevant for the formation of dwarf galaxies. While these predictions are likely generic to models with oscillations in the inflaton potential, the axion monodromy model naturally accommodates the required running spectral index through Planck-scale corrections to the inflaton potential. Applying this model to a combined data set of Planck, ACT, SPT, and WMAP low-$\\ell$ polarization cosmic microwave background (CMB) data, we find a best-fit tensor-to-scalar ratio $r_{0.05} = 0.07^{+0.05}_{-0.04}$ due to gravitational waves, which may have been observed by the BICEP2 experiment. Despite the contribution of gravitational waves, the total power on large scales (CMB power spectrum at low multipoles) is lower than the standard $\\Lambda$CDM cosmology with a power-law spectrum of initial perturbations and no gravitational waves, thus mitigating some of the tension on large scales. There is also a reduction in the matter power spectrum of 20-30\\% at scales corresponding to $k = 10~{\\rm Mpc}^{-1}$, which are relevant for dwarf galaxy formation. This will alleviate some of the unsolved small-scale structure problems in the standard $\\Lambda$CDM cosmology. The inferred matter power spectrum is also found to be consistent with recent Lyman-$\\alpha$ forest data, which is in tension with the Planck-favored $\\Lambda$CDM model with power-law primordial power spectrum.

  8. Receptor for advanced glycation end products inhibits proliferation in osteoblast through suppression of Wnt, PI3K and ERK signaling

    SciTech Connect (OSTI)

    Li, Guofeng [Department of Emergency Surgery, East Hospital, Tongji University School of Medicine, Shanghai 200120 (China)] [Department of Emergency Surgery, East Hospital, Tongji University School of Medicine, Shanghai 200120 (China); Xu, Jingren [Department of Traditional Chinese Orthopaedics, East Hospital, Tongji University School of Medicine, Shanghai 200120 (China)] [Department of Traditional Chinese Orthopaedics, East Hospital, Tongji University School of Medicine, Shanghai 200120 (China); Li, Zengchun, E-mail: lizc.2007@yahoo.com.cn [Department of Emergency Surgery, East Hospital, Tongji University School of Medicine, Shanghai 200120 (China)] [Department of Emergency Surgery, East Hospital, Tongji University School of Medicine, Shanghai 200120 (China)

    2012-07-13T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer RAGE overexpression suppresses cell proliferation in MC3T3-E1 cells. Black-Right-Pointing-Pointer RAGE overexpression decreases Wnt/{beta}-catenin signaling. Black-Right-Pointing-Pointer RAGE overexpression decreases ERK and PI3K signaling. Black-Right-Pointing-Pointer Inhibition of Wnt signaling abolishes PI3K signaling restored by RAGE blockade. Black-Right-Pointing-Pointer Inhibition of Wnt signaling abolishes ERK signaling restored by RAGE blockade. -- Abstract: Expression of receptor for advanced glycation end products (RAGE) plays a crucial role in bone metabolism. However, the role of RAGE in the control of osteoblast proliferation is not yet evaluated. In the present study, we demonstrate that RAGE overexpression inhibits osteoblast proliferation in vitro. The negative regulation of RAGE on cell proliferation results from suppression of Wnt, PI3K and ERK signaling, and is restored by RAGE neutralizing antibody. Prevention of Wnt signaling using Sfrp1 or DKK1 rescues RAGE-decreased PI3K and ERK signaling and cell proliferation, indicating that the altered cell growth in RAGE overexpressing cells is in part secondary to alterations in Wnt signaling. Consistently, RAGE overexpression inhibits the expression of Wnt targets cyclin D1 and c-myc, which is partially reversed by RAGE blockade. Overall, these results suggest that RAGE inhibits osteoblast proliferation via suppression of Wnt, PI3K and ERK signaling, which provides novel mechanisms by which RAGE regulates osteoblast growth.

  9. Chitinase genes revealed and compared in bacterial isolates, DNA extracts and a metagenomic library from a phytopathogen suppressive soil

    SciTech Connect (OSTI)

    Hjort, K.; Bergstrom, M.; Adesina, M.F.; Jansson, J.K.; Smalla, K.; Sjoling, S.

    2009-09-01T23:59:59.000Z

    Soil that is suppressive to disease caused by fungal pathogens is an interesting source to target for novel chitinases that might be contributing towards disease suppression. In this study we screened for chitinase genes, in a phytopathogen-suppressive soil in three ways: (1) from a metagenomic library constructed from microbial cells extracted from soil, (2) from directly extracted DNA and (3) from bacterial isolates with antifungal and chitinase activities. Terminal-restriction fragment length polymorphism (T-RFLP) of chitinase genes revealed differences in amplified chitinase genes from the metagenomic library and the directly extracted DNA, but approximately 40% of the identified chitinase terminal-restriction fragments (TRFs) were found in both sources. All of the chitinase TRFs from the isolates were matched to TRFs in the directly extracted DNA and the metagenomic library. The most abundant chitinase TRF in the soil DNA and the metagenomic library corresponded to the TRF{sup 103} of the isolate, Streptomyces mutomycini and/or Streptomyces clavifer. There were good matches between T-RFLP profiles of chitinase gene fragments obtained from different sources of DNA. However, there were also differences in both the chitinase and the 16S rRNA gene T-RFLP patterns depending on the source of DNA, emphasizing the lack of complete coverage of the gene diversity by any of the approaches used.

  10. Transverse momentum and centrality dependence of high-ptnon-photonic electron suppression in Au+Au collisions at $\\sqrt{s_{NN}}$= 200 GeV

    SciTech Connect (OSTI)

    Abelev, B.I.; Adams, J.; Aggarwal, M.M.; Ahammed, Z.; Amonett,J.; Anderson, B.D.; Anderson, M.; Arkhipkin, D.; Averichev, G.S.; Bai,Y.; Balewski, J.; Barannikova, O.; Barnby, L.S.; Baudot, J.; Bekele, S.; Belaga, V.V.; Bellingeri-Laurikainen, A.; Bellwied, R.; Benedosso, F.; Bhardwaj, S.; Bhasin, A.; Bhati, A.K.; Bichsel, H.; Bielcik, J.; Bielcikova, J.; Bland, L.C.; Blyth, S.-L.; Bonner, B.E.; Botje, M.; Bouchet, J.; Brandin, A.V.; Bravar, A.; Bystersky, M.; Cadman, R.V.; Cai,X.Z.; Caines, H.; Calderon de la Barca Sanchez, M.; Castillo, J.; Catu,O.; Cebra, D.; Chajecki, Z.; Chaloupka, P.; Chattopadhyay, S.; Chen,H.F.; Chen, J.H.; Cheng, J.; Cherney, M.; Chikanian, A.; Christie, W.; Coffin, J.P.; Cormier, T.M.; Cosentino, M.R.; Cramer, J.G.; Crawford,H.J.; Das, D.; Das, S.; Daugherity, M.; de Moura, M.M.; Dedovich, T.G.; DePhillips, M.; Derevschikov, A.A.; Didenko, L.; Dietel, T.; Djawotho,P.; Dogra, S.M.; Dong, W.J.; Dong, X.; Draper, J.E.; Du, F.; Dunin, V.B.; Dunlop, J.C.; Dutta Mazumdar, M.R.; Eckardt, V.; Edwards, W.R.; Efimov,L.G.; Emelianov, V.; Engelage, J.; Eppley, G.; Erazmus, B.; Estienne, M.; Fachini, P.; Fatemi, R.; Fedorisin, J.; Filimonov, K.; Filip, P.; Finch,E.; Fine, V.; Fisyak, Y.; Fu, J.; Gagliardi, C.A.; Gaillard, L.; Ganti,M.S.; Ghazikhanian, V.; Ghosh, P.; Gonzalez, J.S.; Gorbunov, Y.G.; Gos,H.; Grebenyuk, O.; Grosnick, D.; Guertin, S.M.; Guimaraes, K.S.F.F.; Guo,Y.; Gupta, N.; Gutierrez, T.D.; Haag, B.; Hallman, T.J.; Hamed, A.; Harris, J.W.; He, W.; Heinz, M.; Henry, T.W.; Hepplemann, S.; Hippolyte,B.; Hirsch, A.; Hjort, E.; Hoffman, A.M.; Hoffmann, G.W.; Horner, M.J.; Huang, H.Z.; Huang, S.L.; Hughes, E.W.; Humanic, T.J.; Igo, G.; Jacobs,P.; Jacobs, W.W.; Jakl, P.; Jia, F.; Jiang, H.; Jones, P.G.; Judd, E.G.; Kabana, S.; Kang, K.; Kapitan, J.; Kaplan, M.; Keane, D.; Kechechyan, A.; Khodyrev, V.Yu.; Kim, B.C.; Kiryluk, J.; Kisiel, A.; Kislov, E.M.; Klein,S.R.; Kocoloski, A.; Koetke, D.D.; et al.

    2006-07-11T23:59:59.000Z

    The STAR collaboration at RHIC reports measurements of theinclusive yield of non-photonic electrons, which arise dominantly fromsemi-leptonic decays of heavy flavor mesons, over a broad range oftransverse momenta (1.2suppression in central AuAu collisions athigh pt, suggesting substantial heavy quark energy loss at RHIC. Thecentrality and \\pt dependences of the suppression provide constraints ontheoretical models of suppression.

  11. Green tea polyphenol epigallocatechin-3-gallate suppresses melanoma growth by inhibiting inflammasome and IL-1{beta} secretion

    SciTech Connect (OSTI)

    Ellis, Lixia Z.; Liu, Weimin; Luo, Yuchun; Okamoto, Miyako; Qu, Dovina; Dunn, Jeffrey H. [Department of Dermatology, University of Colorado School of Medicine, Aurora, CO 80045 (United States)] [Department of Dermatology, University of Colorado School of Medicine, Aurora, CO 80045 (United States); Fujita, Mayumi, E-mail: mayumi.fujita@ucdenver.edu [Department of Dermatology, University of Colorado School of Medicine, Aurora, CO 80045 (United States) [Department of Dermatology, University of Colorado School of Medicine, Aurora, CO 80045 (United States); Denver Veterans Affairs Medical Center, Denver, CO 80220 (United States)

    2011-10-28T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer EGCG inhibits melanoma cell growth at physiological doses (0.1-1 {mu}M). Black-Right-Pointing-Pointer EGCG inhibits melanoma cell growth via inflammasomes and IL-1{beta} suppression. Black-Right-Pointing-Pointer Inflammasomes and IL-1{beta} could be potential targets for future melanoma therapeutics. -- Abstract: Epigallocatechin-3-gallate (EGCG), the major polyphenolic component of green tea, has been demonstrated to possess anti-inflammatory, antioxidant, anti-mutagenic and anti-carcinogenic properties. The anti-melanoma effect of EGCG has been previously suggested, but no clear mechanism of action has been established. In this study, we demonstrated that EGCG inhibits melanoma cell growth at physiological doses (0.1-1 {mu}M). In the search for mechanisms of EGCG-mediated melanoma cell suppression, we found that NF-{kappa}B was inhibited, and that reduced NF-{kappa}B activity was associated with decreased IL-1{beta} secretion from melanoma cells. Since inflammasomes are involved in IL-1{beta} secretion, we investigated whether IL-1{beta} suppression was mediated by inflammasomes, and found that EGCG treatment led to downregulation of the inflammasome component, NLRP1, and reduced caspase-1 activation. Furthermore, silencing the expression of NLRP1 abolished EGCG-induced inhibition of tumor cell proliferation both in vitro and in vivo, suggesting a key role of inflammasomes in EGCG efficacy. This paper provides a novel mechanism for EGCG-induced melanoma inhibition: inflammasome downregulation {yields} decreased IL-1{beta} secretion {yields} decreased NF-{kappa}B activities {yields} decreased cell growth. In addition, it suggests inflammasomes and IL-1{beta} could be potential targets for future melanoma therapeutics.

  12. Operating Characteristics in DIII-D ELM-Suppressed RMP H-modes with ITER Similar Shapes

    SciTech Connect (OSTI)

    Evans, T E; Fenstermacher, M E; Jakubowski, M; Moyer, R A; Osborne, T H; Schaffer, M J; Schmitz, O; Watkins, J G; Zeng, L; Baylor, L R; Boedo, J A; Burrell, K H; deGrassie, J S; Gohil, P; Joseph, I; Lasnier, C J; Leonard, A W; Mordijck, S; Petty, C C; Pinsker, R I; Rhodes, T L; Rost, J C; Snyder, P B; Unterberg, E; West, W P

    2008-10-13T23:59:59.000Z

    Fast energy transients, incident on the DIII-D divertors due to Type-I edge localized modes (ELMs), are eliminated using small dc currents in a simple set of non-axisymmetric coils that produce edge resonant magnetic perturbations (RMP). In ITER similar shaped (ISS) plasmas, with electron pedestal collisionalities matched to those expected in ITER a sharp resonant window in the safety factor at the 95 percent normalized poloidal flux surface is observed for ELM suppression at q{sub 95}=3.57 with a minimum width {delta}q{sub 95} of {+-}0.05. The size of this resonant window has been increased by a factor of 4 in ISS plasmas by increasing the magnitude of the current in an n=3 coil set along with the current in a separate n=1 coil set. The resonant ELM-suppression window is highly reproducible for a given plasma shape, coil configuration and coil current but can vary with other operating conditions such as {beta}{sub N}. Isolated resonant windows have also been found at other q95 values when using different RMP coil configurations. For example, when the I-coil is operated in an n=3 up-down asymmetric configuration rather than an up-down symmetric configuration a resonant window is found near q{sub 95}=7.4. A Fourier analysis of the applied vacuum magnetic field demonstrates a statistical correlation between the Chirikov island overlap parameter and ELM suppression. These results have been used as a guide for RMP coil design studies in various ITER operating scenarios.

  13. Observation of suppression of light scattering induced by dipole-dipole interactions in a cold atomic ensemble

    E-Print Network [OSTI]

    J. Pellegrino; R. Bourgain; S. Jennewein; Y. R. P. Sortais; S. D. Jenkins; J. Ruostekoski; A. Browaeys

    2014-10-08T23:59:59.000Z

    We study the emergence of collective scattering in the presence of dipole-dipole interactions when we illuminate a cold cloud of rubidium atoms with a near-resonant and weak intensity laser. The size of the atomic sample is comparable to the wavelength of light. When we gradually increase the atom number from 1 to 450, we observe a broadening of the line, a small red shift and, consistently with these, a strong suppression of the scattered light with respect to the noninteracting atom case. Numerical simulations, which include the internal atomic level structure, agree with the data.

  14. Evidence of Magnetic Breakdown on the Defects With Thermally Suppressed Critical Field in High Gradient SRF Cavities

    SciTech Connect (OSTI)

    Eremeev, Grigory [JLAB; Palczewski, Ari [JLAB

    2013-09-01T23:59:59.000Z

    At SRF 2011 we presented the study of quenches in high gradient SRF cavities with dual mode excitation technique. The data differed from measurements done in 80's that indicated thermal breakdown nature of quenches in SRF cavities. In this contribution we present analysis of the data that indicates that our recent data for high gradient quenches is consistent with the magnetic breakdown on the defects with thermally suppressed critical field. From the parametric fits derived within the model we estimate the critical breakdown fields.

  15. Suppression of the thermal hysteresis in magnetocaloric MnAs thin film by highly charged ion bombardment

    E-Print Network [OSTI]

    Trassinelli, Martino; Eddrief, M; Etgens, V H; Gafton, V; Hidki, S; Lacaze, Emmanuelle; Lamour, Emily; Prigent, Christophe; Rozet, Jean-Pierre; Steydli, S; Zheng, Y; Vernhet, Dominique

    2014-01-01T23:59:59.000Z

    We present the investigation on the modifications of structural and magnetic properties of MnAs thin film epitaxially grown on GaAs induced by slow highly charged ions bombardment under well-controlled conditions. The ion-induced defects facilitate the nucleation of one phase with respect to the other in the first-order magneto-structural MnAs transition with a consequent suppression of thermal hysteresis without any significant perturbation on the other structural and magnetic properties. In particular, the irradiated film keeps the giant magnetocaloric effect at room temperature opening new perspective on magnetic refrigeration technology for everyday use.

  16. Branching fraction for the doubly-Cabibbo-suppressed decay D{sup +}{yields}K{sup +}{pi}{sup 0}

    SciTech Connect (OSTI)

    Dytman, S. A.; Love, W.; Savinov, V. [University of Pittsburgh, Pittsburgh, Pennsylvania 15260 (United States); Aquines, O.; Li, Z.; Lopez, A.; Mehrabyan, S.; Mendez, H.; Ramirez, J. [University of Puerto Rico, Mayaguez, Puerto Rico 00681 (Puerto Rico); Huang, G. S.; Miller, D. H.; Pavlunin, V.; Sanghi, B.; Shipsey, I. P. J.; Xin, B. [Purdue University, West Lafayette, Indiana 47907 (United States); Adams, G. S.; Anderson, M.; Cummings, J. P.; Danko, I.; Napolitano, J. [Rensselaer Polytechnic Institute, Troy, New York 12180 (United States)] (and others)

    2006-10-01T23:59:59.000Z

    We present a measurement of the branching fraction for the doubly-Cabibbo-suppressed decay D{sup +}{yields}K{sup +}{pi}{sup 0}, using 281 pb{sup -1} of data accumulated with the CLEO-c detector on the {psi}(3770) resonance. We find B(D{sup +}{yields}K{sup +}{pi}{sup 0})=(2.28{+-}0.36{+-}0.15{+-}0.08)x10{sup -4}, where the first uncertainty is statistical, the second is systematic, and the last error is due to the uncertainty in the reference mode branching fraction.

  17. Suppression of the thermal hysteresis in magnetocaloric MnAs thin film by highly charged ion bombardment

    SciTech Connect (OSTI)

    Trassinelli, M., E-mail: martino.trassinelli@insp.jussieu.fr; Marangolo, M.; Eddrief, M.; Etgens, V. H.; Gafton, V.; Hidki, S.; Lacaze, E.; Lamour, E.; Prigent, C.; Rozet, J.-P.; Steydli, S.; Zheng, Y.; Vernhet, D. [CNRS, UMR 7588, Institut des NanoSciences de Paris (INSP), F-75005 Paris (France); Sorbonne Universités, UPMC Univ. Paris 06, UMR 7588, INSP, F-75005 Paris (France)

    2014-02-24T23:59:59.000Z

    We present the investigation on the modifications of structural and magnetic properties of MnAs thin film epitaxially grown on GaAs induced by slow highly charged ions bombardment under well-controlled conditions. The ion-induced defects facilitate the nucleation of one phase with respect to the other in the first-order magneto-structural MnAs transition, with a consequent suppression of thermal hysteresis without any significant perturbation on the other structural and magnetic properties. In particular, the irradiated film keeps the giant magnetocaloric effect at room temperature opening new perspective on magnetic refrigeration technology for everyday use.

  18. Interaction of nucleus and plastome in sunflower. III. Suppression of phenotypic expression of plastid mutation by alien nucleus

    SciTech Connect (OSTI)

    Beletskii, Yu.D.; Razoriteleva, E.K.

    1988-11-01T23:59:59.000Z

    Four plastome mutations of type chlorina were crossed as female parents with variety Mayak. It was demonstrated that a three-phases hybridization led to the loss of chlorophyll defect in F/sub 1/. The suppression of plastic mutation is controlled by a single dominant gene. Four viable plastid mutants were used in the study-en: chlorina-1 (1-24), en:chlorina-3 (1-138), en:chlorina-5 (2-25), and en:chlorina-7 (2-43).

  19. Corrigendum to “Suppression of ? production in d+Au and Au+Au collisions at ? SNN = 200 GeV" [Phys. Lett. B 735 (2014) 127-137

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Adamczyk, L. [AGH Univ. of Science and Technology, Cracow (Poland)

    2015-04-01T23:59:59.000Z

    We report measurements of ? meson production in p + p, d + Au, and Au+Au collisions using the STAR detector at RHIC. We compare the ? yield to the measured cross section in p + p collisions in order to quantify any modifications of the yield in cold nuclear matter using d + Au data and in hot nuclear matter using Au+Au data separated into three centrality classes. Our p + p measurement is based on three times the statistics of our previous result. We obtain a nuclear modification factor for Upsilon (1S + 2S + 3S) in the rapidity range |y| dAu = 0.79 ± 0.24(stat.) ± 0.03(syst.) ± 0.10(p + p syst.). A comparison with models including shadowing and initial state parton energy loss indicates the presence of additional cold-nuclear matter suppression. Similarly, in the top 10% most-central Au + Au collisions, we measure a nuclear modification factor of R AA = 0.49 ±0.1(stat.) ±0.02(syst.) ±0.06(p + p syst.), which is a larger suppression factor than that seen in cold nuclear matter. Our results are consistent with complete suppression of excited-state Upsilon mesons in Au + Au collisions. The additional suppression in Au + Au is consistent with the level expected in model calculations that include the presence of a hot, deconfined Quark–Gluon Plasma. However, understanding the suppression seen in d + Au is still needed before any definitive statements about the nature of the suppression in Au + Au can be made.

  20. Corrigendum to “Suppression of ? production in d+Au and Au+Au collisions at ? SNN = 200 GeV" [Phys. Lett. B 735 (2014) 127-137

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Adamczyk, L.

    2015-04-01T23:59:59.000Z

    We report measurements of ? meson production in p + p, d + Au, and Au+Au collisions using the STAR detector at RHIC. We compare the ? yield to the measured cross section in p + p collisions in order to quantify any modifications of the yield in cold nuclear matter using d + Au data and in hot nuclear matter using Au+Au data separated into three centrality classes. Our p + p measurement is based on three times the statistics of our previous result. We obtain a nuclear modification factor for Upsilon (1S + 2S + 3S) in themore »rapidity range |y| dAu = 0.79 ± 0.24(stat.) ± 0.03(syst.) ± 0.10(p + p syst.). A comparison with models including shadowing and initial state parton energy loss indicates the presence of additional cold-nuclear matter suppression. Similarly, in the top 10% most-central Au + Au collisions, we measure a nuclear modification factor of R AA = 0.49 ±0.1(stat.) ±0.02(syst.) ±0.06(p + p syst.), which is a larger suppression factor than that seen in cold nuclear matter. Our results are consistent with complete suppression of excited-state Upsilon mesons in Au + Au collisions. The additional suppression in Au + Au is consistent with the level expected in model calculations that include the presence of a hot, deconfined Quark–Gluon Plasma. However, understanding the suppression seen in d + Au is still needed before any definitive statements about the nature of the suppression in Au + Au can be made.« less

  1. Suppression of Upsilon Production in d+Au and Au+Au Collisions at sqrt(s_NN) = 200 GeV

    E-Print Network [OSTI]

    L. Adamczyk; J. K. Adkins; G. Agakishiev; M. M. Aggarwal; Z. Ahammed; I. Alekseev; J. Alford; C. D. Anson; A. Aparin; D. Arkhipkin; E. C. Aschenauer; G. S. Averichev; A. Banerjee; D. R. Beavis; R. Bellwied; A. Bhasin; A. K. Bhati; P. Bhattarai; H. Bichsel; J. Bielcik; J. Bielcikova; L. C. Bland; I. G. Bordyuzhin; W. Borowski; J. Bouchet; A. V. Brandin; S. G. Brovko; S. Bültmann; I. Bunzarov; T. P. Burton; J. Butterworth; H. Caines; M. Calderón de la Barca Sánchez; D. Cebra; R. Cendejas; M. C. Cervantes; P. Chaloupka; Z. Chang; S. Chattopadhyay; H. F. Chen; J. H. Chen; L. Chen; J. Cheng; M. Cherney; A. Chikanian; W. Christie; J. Chwastowski; M. J. M. Codrington; G. Contin; J. G. Cramer; H. J. Crawford; X. Cui; S. Das; A. Davila Leyva; L. C. De Silva; R. R. Debbe; T. G. Dedovich; J. Deng; A. A. Derevschikov; R. Derradi de Souza; S. Dhamija; B. di Ruzza; L. Didenko; C. Dilks; F. Ding; P. Djawotho; X. Dong; J. L. Drachenberg; J. E. Draper; C. M. Du; L. E. Dunkelberger; J. C. Dunlop; L. G. Efimov; J. Engelage; K. S. Engle; G. Eppley; L. Eun; O. Evdokimov; R. Fatemi; S. Fazio; J. Fedorisin; P. Filip; E. Finch; Y. Fisyak; C. E. Flores; C. A. Gagliardi; D. R. Gangadharan; D. Garand; F. Geurts; A. Gibson; M. Girard; S. Gliske; L. Greiner; D. Grosnick; Y. Guo; A. Gupta; S. Gupta; W. Guryn; B. Haag; O. Hajkova; A. Hamed; L-X. Han; R. Haque; J. W. Harris; S. Heppelmann; K. Hill; A. Hirsch; G. W. Hoffmann; D. J. Hofman; S. Horvat; B. Huang; H. Z. Huang; X. Huang; P. Huck; T. J. Humanic; G. Igo; W. W. Jacobs; H. Jang; E. G. Judd; S. Kabana; D. Kalinkin; K. Kang; K. Kauder; H. W. Ke; D. Keane; A. Kechechyan; A. Kesich; Z. H. Khan; D. P. Kikola; I. Kisel; A. Kisiel; D. D. Koetke; T. Kollegger; J. Konzer; I. Koralt; L. Kotchenda; P. Kravtsov; K. Krueger; I. Kulakov; L. Kumar; R. A. Kycia; M. A. C. Lamont; J. M. Landgraf; K. D. Landry; J. Lauret; A. Lebedev; R. Lednicky; J. H. Lee; M. J. LeVine; C. Li; W. Li; X. Li; X. Li; Y. Li; Z. M. Li; L. M. Lima; M. A. Lisa; F. Liu; T. Ljubicic; W. J. Llope; M. Lomnitz; R. S. Longacre; X. Luo; G. L. Ma; Y. G. Ma; D. M. M. D. Madagodagettige Don; D. P. Mahapatra; R. Majka; S. Margetis; C. Markert; H. Masui; H. S. Matis; D. McDonald; T. S. McShane; N. G. Minaev; S. Mioduszewski; B. Mohanty; M. M. Mondal; D. A. Morozov; M. G. Munhoz; M. K. Mustafa; B. K. Nandi; Md. Nasim; T. K. Nayak; J. M. Nelson; G. Nigmatkulov; L. V. Nogach; S. Y. Noh; J. Novak; S. B. Nurushev; G. Odyniec; A. Ogawa; K. Oh; A. Ohlson; V. Okorokov; E. W. Oldag; R. A. N. Oliveira; M. Pachr; B. S. Page; S. K. Pal; Y. X. Pan; Y. Pandit; Y. Panebratsev; T. Pawlak; B. Pawlik; H. Pei; C. Perkins; W. Peryt; A. Peterson; P. Pile; M. Planinic; J. Pluta; N. Poljak; J. Porter; A. M. Poskanzer; N. K. Pruthi; M. Przybycien; P. R. Pujahari; J. Putschke; H. Qiu; A. Quintero; S. Ramachandran; R. Raniwala; S. Raniwala; R. L. Ray; C. K. Riley; H. G. Ritter; J. B. Roberts; O. V. Rogachevskiy; J. L. Romero; J. F. Ross; A. Roy; L. Ruan; J. Rusnak; N. R. Sahoo; P. K. Sahu; I. Sakrejda; S. Salur; J. Sandweiss; E. Sangaline; A. Sarkar; J. Schambach; R. P. Scharenberg; A. M. Schmah; W. B. Schmidke; N. Schmitz; J. Seger; P. Seyboth; N. Shah; E. Shahaliev; P. V. Shanmuganathan; M. Shao; B. Sharma; W. Q. Shen; S. S. Shi; Q. Y. Shou; E. P. Sichtermann; R. N. Singaraju; M. J. Skoby; D. Smirnov; N. Smirnov; D. Solanki; P. Sorensen; U. G. deSouza; H. M. Spinka; B. Srivastava; T. D. S. Stanislaus; J. R. Stevens; R. Stock; M. Strikhanov; B. Stringfellow; A. A. P. Suaide; M. Sumbera; X. Sun; X. M. Sun; Y. Sun; Z. Sun; B. Surrow; D. N. Svirida; T. J. M. Symons; A. Szanto de Toledo; M. A. Szelezniak; J. Takahashi; A. H. Tang; Z. Tang; T. Tarnowsky; J. H. Thomas; A. R. Timmins; D. Tlusty; M. Tokarev; S. Trentalange; R. E. Tribble; P. Tribedy; B. A. Trzeciak; O. D. Tsai; J. Turnau; T. Ullrich; D. G. Underwood; G. Van Buren; G. van Nieuwenhuizen; J. A. Vanfossen, Jr.; R. Varma; G. M. S. Vasconcelos; A. N. Vasiliev; R. Vertesi; F. Videbæk; Y. P. Viyogi; S. Vokal; A. Vossen; M. Wada; F. Wang; G. Wang; H. Wang; J. S. Wang; X. L. Wang; Y. Wang; Y. Wang; G. Webb; J. C. Webb; G. D. Westfall; H. Wieman; G. Wimsatt; S. W. Wissink; R. Witt; Y. F. Wu; Z. Xiao; W. Xie; K. Xin; H. Xu; J. Xu; N. Xu; Q. H. Xu; Y. Xu; Z. Xu; W. Yan; C. Yang; Y. Yang; Y. Yang; Z. Ye; P. Yepes; L. Yi; K. Yip; I-K. Yoo; N. Yu; Y. Zawisza; H. Zbroszczyk; W. Zha; J. B. Zhang; J. L. Zhang; S. Zhang; X. P. Zhang; Y. Zhang; Z. P. Zhang; F. Zhao; J. Zhao; C. Zhong; X. Zhu; Y. H. Zhu; Y. Zoulkarneeva; M. Zyzak

    2015-01-21T23:59:59.000Z

    We report measurements of Upsilon meson production in p+p, d+Au, and Au+Au collisions using the STAR detector at RHIC. We compare the Upsilon yield to the measured cross section in p+p collisions in order to quantify any modifications of the yield in cold nuclear matter using d+Au data and in hot nuclear matter using Au+Au data separated into three centrality classes. Our p+p measurement is based on three times the statistics of our previous result. We obtain a nuclear modification factor for Upsilon(1S+2S+3S) in the rapidity range |y|<1 in d+Au collisions of R_dAu = 0.79 +/- 0.24 (stat.) +/- 0.03 (sys.) +/- 0.10 (pp sys.). A comparison with models including shadowing and initial state parton energy loss indicates the presence of additional cold-nuclear matter suppression. Similarly, in the top 10% most-central Au+Au collisions, we measure a nuclear modification factor of R_AA=0.49 +/- 0.1 (stat.) +/- 0.02 (sys.) +/- 0.06 (pp sys.), which is a larger suppression factor than that seen in cold nuclear matter. Our results are consistent with complete suppression of excited-state Upsilon mesons in Au+Au collisions. The additional suppression in Au+Au is consistent with the level expected in model calculations that include the presence of a hot, deconfined Quark-Gluon Plasma. However, understanding the suppression seen in d+Au is still needed before any definitive statements about the nature of the suppression in Au+Au can be made.

  2. Suppression of infrared instability in trans-sonic flows by condensation of zero-frequency short wave length phonons

    E-Print Network [OSTI]

    Xavier Busch; Florent Michel; Renaud Parentani

    2015-02-06T23:59:59.000Z

    We analyze the peculiar infrared instability that characterizes stationary inhomogeneous flows when their velocity crosses the sound speed by decreasing values. For definiteness, we work in the context of one dimensional atomic Bose condensates. These flows are unstable under ultra low real frequency perturbations because of the unbounded mode amplification near the sonic horizon. This results in a condensation of low frequency phonons which produces a spatially structured flow in the supersonic domain. Numerical simulations reveal that this zero-frequency undulation suppresses the instability when its spatial extension is infinite, and when its phase is near that of a "shadow soliton" solution attached to the sonic horizon. These phenomena are akin to the condensation of rotons in flowing superfluid helium-4 when exceeding the Landau velocity. They also pertain to shallow water waves propagating on transcritical flows.

  3. Blinking suppression of CdTe quantum dots on epitaxial graphene and the analysis with Marcus electron transfer

    SciTech Connect (OSTI)

    Hirose, Takuya; Tamai, Naoto, E-mail: tamai@kwansei.ac.jp [Department of Chemistry, School of Science and Technology, Kwansei Gakuin University, 2-1 Gakuen, Sanda, Hyogo 669-1337 (Japan); Kutsuma, Yasunori; Kurita, Atsusi; Kaneko, Tadaaki [Department of Physics, School of Science and Technology, Kwansei Gakuin University, 2-1 Gakuen, Sanda, Hyogo 669-1337 (Japan)

    2014-08-25T23:59:59.000Z

    We have prepared epitaxial graphene by a Si sublimation method from 4H-SiC. Single-particle spectroscopy of CdTe quantum dots (QDs) on epitaxial graphene covered with polyvinylpyrrolidone (PVP) or polyethylene glycol (PEG) showed the suppression of luminescence blinking and ?10 times decreased luminescence intensity as compared with those on a glass. The electronic coupling constant, H{sub 01}, between CdTe QDs and graphene was calculated to be (3.3?±?0.4)?×?10{sup 2?}cm{sup ?1} in PVP and (3.7?±?0.8)?×?10{sup 2?}cm{sup ?1} in PEG based on Marcus theory of electron transfer and Tang-Marcus model of blinking with statistical distribution.

  4. Suppression of Faraday waves in a Bose-Einstein condensate in the presence of an optical lattice

    SciTech Connect (OSTI)

    Capuzzi, Pablo [Departamento de Fisica, FCEN Universidad de Buenos Aires, Ciudad Universitaria, Pab. I C1428EGA Buenos Aires (Argentina); Instituto de Fisica de Buenos Aires-CONICET (Argentina); Gattobigio, Mario; Vignolo, Patrizia [Universite de Nice-Sophia Antipolis, Institut non Lineaire de Nice, CNRS, 1361 route des Lucioles, F-06560 Valbonne (France)

    2011-01-15T23:59:59.000Z

    We study the formation of Faraday waves in an elongated Bose-Einstein condensate in the presence of a one-dimensional optical lattice. The waves are parametrically excited by modulating the radial confinement of the condensate close to a transverse breathing mode of the system. For very shallow optical lattices, phonons with a well-defined wave vector propagate along the condensate, as in the absence of the lattice, and we observe the formation of a Faraday pattern. We find that by increasing the potential depth the local sound velocity decreases, and when it equals the condensate local phase velocity, the condensate develops an incoherent superposition of several modes and the parametric excitation of Faraday waves is suppressed.

  5. Narrow-band injection seeding of a terahertz frequency quantum cascade laser: Selection and suppression of longitudinal modes

    SciTech Connect (OSTI)

    Nong, Hanond, E-mail: Nong.Hanond@rub.de; Markmann, Sergej; Hekmat, Negar; Jukam, Nathan, E-mail: Nathan.Jukam@rub.de [Arbeitsgruppe Terahertz Spektroskopie und Technologie, Ruhr-Universität Bochum, Bochum 44780 (Germany); Pal, Shovon [Arbeitsgruppe Terahertz Spektroskopie und Technologie, Ruhr-Universität Bochum, Bochum 44780 (Germany); Lehrstuhl für Angewandte Festkörperphysik, Ruhr-Universität Bochum, Bochum 44780 (Germany); Mohandas, Reshma A.; Dean, Paul; Li, Lianhe; Linfield, Edmund H.; Giles Davies, A. [School of Electronic and Electrical Engineering, University of Leeds, Leeds LS2 9JT (United Kingdom); Wieck, Andreas D. [Lehrstuhl für Angewandte Festkörperphysik, Ruhr-Universität Bochum, Bochum 44780 (Germany)

    2014-09-15T23:59:59.000Z

    A periodically poled lithium niobate (PPLN) crystal with multiple poling periods is used to generate tunable narrow-bandwidth THz pulses for injection seeding a quantum cascade laser (QCL). We demonstrate that longitudinal modes of the quantum cascade laser close to the gain maximum can be selected or suppressed according to the seed spectrum. The QCL emission spectra obtained by electro-optic sampling from the quantum cascade laser, in the most favorable case, shows high selectivity and amplification of the longitudinal modes that overlap the frequency of the narrow-band seed. Proper selection of the narrow-band THz seed from the PPLN crystal discretely tunes the longitudinal mode emission of the quantum cascade laser. Moreover, the THz wave build-up within the laser cavity is studied as a function of the round-trip time. When the seed frequency is outside the maximum of the gain spectrum the laser emission shifts to the preferential longitudinal mode.

  6. Electrowetting on liquid-infused film (EWOLF): Complete reversibility and controlled droplet oscillation suppression for fast optical imaging

    E-Print Network [OSTI]

    Hao, Chonglei; Chen, Xuemei; He, Yuncheng; Li, Qiusheng; Li, K Y; Wang, Zuankai

    2014-01-01T23:59:59.000Z

    Electrowetting on dielectric (EWOD) has emerged as a powerful tool to electrically manipulate tiny individual droplets in a controlled manner. Despite tremendous progress over the past two decades, current EWOD operating in ambient conditions has limited functionalities posing challenges for its applications, including electronic display, energy generation, and microfluidic systems. Here, we demonstrate a new paradigm of electrowetting on liquid-infused film (EWOLF) that allows for complete reversibility and tunable transient response simultaneously. We determine that these functionalities in EWOLF are attributed to its novel configuration, which allows for the formation of viscous liquid-liquid interfaces as well as additional wetting ridges, thereby suppressing the contact line pinning and severe droplet oscillation encountered in the conventional EWOD. Finally, by harnessing these functionalities demonstrated in EWOLF, we also explore its application as liquid lens for fast optical focusing.

  7. Centrality dependence of high $p_T$ suppression in Au+Au collisions suggest quark matter formation

    E-Print Network [OSTI]

    A. K. Chaudhuri

    2004-05-12T23:59:59.000Z

    In a pQCD-based model, we have analyzed the STAR data on the high $p_T$ suppression of charged hadrons, in Au+Au collisions at $\\sqrt{s}$=200 GeV. In the jet quenching or the energy loss picture, $p_T$ spectra of charged hadrons as well as the $p_T$ dependence of nuclear modification factor, in all the centrality ranges, are well explained, with nearly a constant relative energy loss, $\\Delta E/E=0.56\\pm 0.03$. Centrality independence of relative energy loss indicate that the matter produced in central and in peripheral collisions are different, otherwise relative energy loss would have shown strong centrality dependence. Qualitatively, centrality independence of relative energy loss can be understood, if in central Au+Au collisions deconfined matter is produced and the matter remain confined in peripheral collisions.

  8. Comment to `The dependence of the anomalous J/psi suppression on the number of participant nucleons'

    E-Print Network [OSTI]

    A. P. Kostyuk; H. Stoecker; W. Greiner

    2002-07-28T23:59:59.000Z

    The recently published experimental dependence of the J/psi suppression pattern in Pb+Pb collisions at the CERN SPS on the energy of zero degree calorimeter E_ZDC are analyzed. It is found that the data obtained within the `minimum bias' analysis (using `theoretical Drell-Yan') are at variance with the previously published experimental dependence of the same quantity on the transversal energy of neutral hadrons E_T. The discrepancy is related to the moderate centrality region: 100 < N_p < 200 (N_p is the number of nucleon participants). This could result from systematic experimental errors in the minimum bias sample. A possible source of the errors may be contamination of the minimum bias sample by off-target interactions. The data obtained within the standard analysis (using measured Drell-Yan multiplicity) are found to be much less sensitive to the contamination.

  9. Suppression of high-order-harmonic intensities observed in aligned CO{sub 2} molecules with 1300-nm and 800-nm pulses

    SciTech Connect (OSTI)

    Kato, Kosaku; Minemoto, Shinichirou; Sakai, Hirofumi [Department of Physics, Graduate School of Science, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)

    2011-08-15T23:59:59.000Z

    High-order-harmonic generation from aligned N{sub 2}, O{sub 2}, and CO{sub 2} molecules is investigated by 1300-nm and 800-nm pulses. The harmonic intensities of 1300-nm pulses from aligned molecules show harmonic photon energy dependence similar to those of 800-nm pulses. Suppression of harmonic intensity from aligned CO{sub 2} molecules is observed for both 1300- and 800-nm pulses over the same harmonic photon energy range. As the dominant mechanism for the harmonic intensity suppression from aligned CO{sub 2} molecules, the present results support the two-center interference picture rather than the dynamical interference picture.

  10. Ascorbic acid suppresses endotoxemia and NF-?B signaling cascade in alcoholic liver fibrosis in guinea pigs: A mechanistic approach

    SciTech Connect (OSTI)

    Abhilash, P.A.; Harikrishnan, R.; Indira, M., E-mail: indiramadambath@gmail.com

    2014-01-15T23:59:59.000Z

    Alcohol consumption increases the small intestinal bacterial overgrowth (SIBO) and intestinal permeability of endotoxin. The endotoxin mediated inflammatory signaling plays a major role in alcoholic liver fibrosis. We evaluated the effect of ascorbic acid (AA), silymarin and alcohol abstention on the alcohol induced endotoxemia and NF-?B activation cascade pathway in guinea pigs (Cavia porcellus). Guinea pigs were administered ethanol at a daily dose of 4 g/kg b.wt for 90 days. After 90 days, ethanol administration was stopped. The ethanol treated animals were divided into abstention, silymarin (250 mg/kg b.wt) and AA (250 mg/kg b.wt) supplemented groups and maintained for 30 days. The SIBO, intestinal permeability and endotoxin were significantly increased in the ethanol group. The mRNA expressions of intestinal proteins claudin, occludin and zona occludens-1 were significantly decreased in ethanol group. The mRNA levels of inflammatory receptors, activity of IKK? and the protein expressions of phospho-I?B?, NF-?B, TNF-?, TGF-?{sub 1} and IL-6 were also altered in ethanol group. The expressions of fibrosis markers ?-SMA, ?{sub 1} (I) collagen and sirius red staining in the liver revealed the induction of fibrosis. But the supplementation of AA could induce greater reduction of ethanol induced SIBO, intestinal barrier defects, NF-?B activation and liver fibrosis than silymarin. The possible mechanism may be the inhibitory effect of AA on SIBO, intestinal barrier defect and IKK?, which decreased the activation of NF-?B and synthesis of cytokines. This might have led to suppression of HSCs activation and liver fibrosis. - Highlights: • Alcohol increases intestinal bacterial overgrowth and permeability of endotoxin. • Endotoxin mediated inflammation plays a major role in alcoholic liver fibrosis. • Ascorbic acid reduces endotoxemia, NF-?B activation and proinflammatory cytokines. • AA's action is by inhibition of SIBO, IKK? and alteration of intestinal permeability. • This might have led to suppression of HSCs activation and liver fibrosis.

  11. Charge-transfer-induced suppression of galvanic replacement and synthesis of (Au-Ag)-Au double shell nanoparticles for highly uniform, robust and sensitive bioprobes

    SciTech Connect (OSTI)

    Dao Thi Ngoc Anh; Singh, Prerna; Shankar, Cheshta; Mott, Derrick; Maenosono, Shinya [Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa 923-1292 (Japan)

    2011-08-15T23:59:59.000Z

    The synthesis of double shell (Au-Ag)-Au nanoparticles is accomplished through suppression of the galvanic replacement reaction caused by an electron transfer phenomenon. The resulting nanoparticles are monodisperse with a thin and uniform second Au shell. These particles are ultimately expected to lead to sensitive probes for biomolecular sensing and diagnostics.

  12. British Journal of Nutrition, 2010, Allam et al., Calcium carbonate blocks haem without side effect. Authors' Version 1 Calcium Carbonate Suppresses Haem Toxicity Markers without

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    British Journal of Nutrition, 2010, Allam et al., Calcium carbonate blocks haem without side effect. Authors' Version 1 Calcium Carbonate Suppresses Haem Toxicity Markers without Calcium Phosphate Side identified calcium carbonate as the most effective calcium salt to bind haem in vitro and to decrease faecal

  13. Edge-Localized-Mode Suppression through Density-Profile Modification with Lithium-Wall Coatings in the National Spherical Torus Experiment

    E-Print Network [OSTI]

    Princeton Plasma Physics Laboratory

    a pulsed power load that would limit the lifetime of plasma-facing components (PFCs) unless the energyEdge-Localized-Mode Suppression through Density-Profile Modification with Lithium-Wall Coatings to low-n peeling or ballooning modes, while broader pressure profiles stabilized the post-Li discharges

  14. Impaired NFAT and NF?B activation are involved in suppression of CD40 ligand expression by ?{sup 9}-tetrahydrocannabinol in human CD4{sup +} T cells

    SciTech Connect (OSTI)

    Ngaotepprutaram, Thitirat [Department of Pharmacology and Toxicology, Michigan State University (United States); Center for Integrative Toxicology, Michigan State University (United States); Kaplan, Barbara L.F. [Department of Pharmacology and Toxicology, Michigan State University (United States); Center for Integrative Toxicology, Michigan State University (United States); Neuroscience Program, Michigan State University (United States); Kaminski, Norbert E., E-mail: kamins11@msu.edu [Department of Pharmacology and Toxicology, Michigan State University (United States); Center for Integrative Toxicology, Michigan State University (United States)

    2013-11-15T23:59:59.000Z

    We have previously reported that ?{sup 9}-tetrahydrocannabinol (?{sup 9}-THC), the main psychoactive cannabinoid in marijuana, suppresses CD40 ligand (CD40L) expression by activated mouse CD4{sup +} T cells. CD40L is involved in pathogenesis of many autoimmune and inflammatory diseases. In the present study, we investigated the molecular mechanism of ?{sup 9}-THC-mediated suppression of CD40L expression using peripheral blood human T cells. Pretreatment with ?{sup 9}-THC attenuated CD40L expression in human CD4{sup +} T cells activated by anti-CD3/CD28 at both the protein and mRNA level, as determined by flow cytometry and quantitative real-time PCR, respectively. Electrophoretic mobility shift assays revealed that ?{sup 9}-THC suppressed the DNA-binding activity of both NFAT and NF?B to their respective response elements within the CD40L promoter. An assessment of the effect of ?{sup 9}-THC on proximal T cell-receptor (TCR) signaling induced by anti-CD3/CD28 showed significant impairment in the rise of intracellular calcium, but no significant effect on the phosphorylation of ZAP70, PLC?1/2, Akt, and GSK3?. Collectively, these findings identify perturbation of the calcium-NFAT and NF?B signaling cascade as a key mechanistic event by which ?{sup 9}-THC suppresses human T cell function. - Highlights: • ?{sup 9}-THC attenuated CD40L expression in activated human CD4+ T cells. • ?{sup 9}-THC suppressed DNA-binding activity of NFAT and NF?B. • ?{sup 9}-THC impaired elevation of intracellular Ca2+. • ?{sup 9}-THC did not affect phosphorylation of ZAP70, PLC?1/2, Akt, and GSK3?.

  15. Chemokines, macrophage inflammatory protein-2 and stromal cell-derived factor-1{alpha}, suppress amyloid {beta}-induced neurotoxicity

    SciTech Connect (OSTI)

    Raman, Dayanidhi; Milatovic, Snjezana-Zaja [Department of Cancer Biology, Vanderbilt University, School of Medicine, Nashville, TN 37232 (United States)] [Department of Cancer Biology, Vanderbilt University, School of Medicine, Nashville, TN 37232 (United States); Milatovic, Dejan [Department of Pediatrics/Pediatric Toxicology, Vanderbilt University, School of Medicine, Nashville, TN 37232 (United States)] [Department of Pediatrics/Pediatric Toxicology, Vanderbilt University, School of Medicine, Nashville, TN 37232 (United States); Splittgerber, Ryan [Department of Cancer Biology, Vanderbilt University, School of Medicine, Nashville, TN 37232 (United States)] [Department of Cancer Biology, Vanderbilt University, School of Medicine, Nashville, TN 37232 (United States); Fan, Guo-Huang [Department of Neurobiology and Neurotoxicology, Meharry Medical College, Nashville, TN 37221 (United States)] [Department of Neurobiology and Neurotoxicology, Meharry Medical College, Nashville, TN 37221 (United States); Richmond, Ann, E-mail: ann.richmond@vanderbilt.edu [VA Medical Center, Nashville, TN 37232 (United States) [VA Medical Center, Nashville, TN 37232 (United States); Department of Cancer Biology, Vanderbilt University, School of Medicine, Nashville, TN 37232 (United States)

    2011-11-15T23:59:59.000Z

    Alzheimer's disease (AD) is characterized by a progressive cognitive decline and accumulation of neurotoxic oligomeric peptides amyloid-{beta} (A{beta}). Although the molecular events are not entirely known, it has become evident that inflammation, environmental and other risk factors may play a causal, disruptive and/or protective role in the development of AD. The present study investigated the ability of the chemokines, macrophage inflammatory protein-2 (MIP-2) and stromal cell-derived factor-1{alpha} (SDF-1{alpha}), the respective ligands for chemokine receptors CXCR2 and CXCR4, to suppress A{beta}-induced neurotoxicity in vitro and in vivo. Pretreatment with MIP-2 or SDF-1{alpha} significantly protected neurons from A{beta}-induced dendritic regression and apoptosis in vitro through activation of Akt, ERK1/2 and maintenance of metalloproteinase ADAM17 especially with SDF-1{alpha}. Intra-cerebroventricular (ICV) injection of A{beta} led to reduction in dendritic length and spine density of pyramidal neurons in the CA1 area of the hippocampus and increased oxidative damage 24 h following the exposure. The A{beta}-induced morphometric changes of neurons and increase in biomarkers of oxidative damage, F{sub 2}-isoprostanes, were significantly inhibited by pretreatment with the chemokines MIP-2 or SDF-1{alpha}. Additionally, MIP-2 or SDF-1{alpha} was able to suppress the aberrant mislocalization of p21-activated kinase (PAK), one of the proteins involved in the maintenance of dendritic spines. Furthermore, MIP-2 also protected neurons against A{beta} neurotoxicity in CXCR2-/- mice, potentially through observed up regulation of CXCR1 mRNA. Understanding the neuroprotective potential of chemokines is crucial in defining the role for their employment during the early stages of neurodegeneration. -- Research highlights: Black-Right-Pointing-Pointer Neuroprotective ability of the chemokines MIP2 and CXCL12 against A{beta} toxicity. Black-Right-Pointing-Pointer MIP-2 or CXCL12 prevented dendritic regression and apoptosis in vitro. Black-Right-Pointing-Pointer Neuroprotection through activation of Akt, ERK1/2 and maintenance of ADAM17. Black-Right-Pointing-Pointer Neuroprotection of hippocampal pyramidal neurons in vivo by MIP-2 or CXCL12. Black-Right-Pointing-Pointer MIP-2 or CXCL12 prevent elevation of F2-Isoprostanes against A{beta} treatment.

  16. Driving toroidally asymmetric current through the tokamak scrape-off layer, Part I: Potential for ELM suppression

    SciTech Connect (OSTI)

    Joseph, I; Cohen, R H; Ryutov, D D

    2009-03-31T23:59:59.000Z

    A potential technique for suppressing edge localized magnetohydrodynamic instabilities (ELMs) is theoretically analyzed. Recent experiments have shown that externally generated resonant magnetic perturbations (RMPs) can stabilize ELMs by modifying the density profile [T. E. Evans, et al., Nature Phys. 2, 419 (2006); Y. Liang, et al., Phys. Rev. Lett. 98, 265004 (2007)]. Driving toroidally asymmetric current internally, through the scrape-off layer (SOL) plasma itself, can also generate RMPs that are close to the required threshold for ELM control. The limiting ion saturation current densities can be achieved by producing potential differences on the order of the electron temperature. Although the threshold is uncertain in future devices, if driven coherently though the SOL, the upper limit for the resulting field would exceed the present experimental threshold. This analysis provides the tools required for estimating the magnitude of the coherent SOL current and RMP generated via toroidally asymmetric biasing of the target. Flux expansion increases the RMP near the X-point, while phase interference due to the shearing of field lines near the X-point reduces the amplitude of the effective SOL perturbation and makes the result sensitive to both toroidal mode number n and the radial coherence width of the biasing region. If the limiting current density decays rapidly enough radially, both the width and the amplitude of the current density drawn from the target will be reduced. The RMP can still exceed the present threshold at low n if the radial location and width of the biasing region are optimally chosen.

  17. Suppression of chaos at slow variables by rapidly mixing fast dynamics through linear energy-preserving coupling

    E-Print Network [OSTI]

    Rafail V. Abramov

    2011-08-14T23:59:59.000Z

    Chaotic multiscale dynamical systems are common in many areas of science, one of the examples being the interaction of the low-frequency dynamics in the atmosphere with the fast turbulent weather dynamics. One of the key questions about chaotic multiscale systems is how the fast dynamics affects chaos at the slow variables, and, therefore, impacts uncertainty and predictability of the slow dynamics. Here we demonstrate that the linear slow-fast coupling with the total energy conservation property promotes the suppression of chaos at the slow variables through the rapid mixing at the fast variables, both theoretically and through numerical simulations. A suitable mathematical framework is developed, connecting the slow dynamics on the tangent subspaces to the infinite-time linear response of the mean state to a constant external forcing at the fast variables. Additionally, it is shown that the uncoupled dynamics for the slow variables may remain chaotic while the complete multiscale system loses chaos and becomes completely predictable at the slow variables through increasing chaos and turbulence at the fast variables. This result contradicts the common sense intuition, where, naturally, one would think that coupling a slow weakly chaotic system with another much faster and much stronger mixing system would result in general increase of chaos at the slow variables.

  18. Development of electron reflection suppression materials for improved thermionic energy converter performance using thin film deposition techniques

    SciTech Connect (OSTI)

    Islam, Mohammad; Inal, Osman T.; Luke, James R. [Department of Materials and Metallurgical Engineering, New Mexico Institute of Mining and Technology, Socorro, New Mexico 87801 (United States); New Mexico Institute of Mining and Technology, Institute for Engineering Research and Applications (IERA) , 901 University Blvd. SE, Albuquerque, New Mexico 87106-4339 (United States)

    2006-10-15T23:59:59.000Z

    Nonideal electrode surfaces cause significant degree of electron reflection from collector during thermionic converter operation. The effect of the collector surface structure on the converter performance was assessed through the development of several electron reflection suppression materials using various thin film deposition techniques. The double-diode probe method was used to compare the J-V characteristics of converters with polished and modified collector surfaces for emitter temperature and cesium vapor pressure in the ranges of 900-2000 K and 0.02-1.5 torr, respectively. The coadsorption of cesium and oxygen with respective partial vapor pressures of {approx}1.27 torr and a few microtorrs reduced the emitter work function to a minimum value of 0.99 eV. It was found that the collector surfaces with matte black appearance such as platinum black, voided nickel from radio-frequency plasma sputtering, and etched electroless Ni-P with craterlike pore morphology exhibited much better performance compared with polished collector surface. For these thin films, the increase in the maximum output voltage was up to 2.0 eV. For optimum performance with minimum work function and maximum saturation emission current density, the emitter temperature was in the range of 1100-1500 K, depending on the collector surface structure. The use of these materials in cylindrical converter design and/or in combination with hybrid mode triode configuration holds great potential in low and medium scale power generators for commercial use.

  19. Measurements of $\\Lambda^+_c$ Branching Fractions of Cabibbo-Suppressed Decay Modes involving $\\Lambda$ and $\\Sigma^{0}$

    E-Print Network [OSTI]

    Aubert, B; Abrams, G S; Adye, T; Ahmed, M; Ahmed, S; Alam, M S; Albert, J; Aleksan, Roy; Allen, M T; Allison, J; Allmendinger, T; Altenburg, D; Andreassen, R; Andreotti, M; Angelini, C; Anulli, F; Arnaud, N; Aston, D; Azzolini, V; Baak, M; Back, J J; Baldini-Ferroli, R; Band, H R; Banerjee, S; Barate, R; Bard, D J; Barlow, N R; Barlow, R J; Barrett, M; Bartoldus, R; Batignani, G; Battaglia, M; Bauer, J M; Beck, T W; Behera, P K; Bellini, F; Benayoun, M; Benelli, G; Berger, N; Bernard, D; Berryhill, J W; Best, D; Bettarini, S; Bettoni, D; Bevan, A J; Bhimji, W; Bhuyan, B; Bianchi, F; Biasini, M; Biesiada, J; Blanc, F; Blaylock, G; Blinov, A E; Blinov, V E; Bloom, P C; Blount, N L; Bomben, M; Bondioli, M; Bonneaud, G R; Bosisio, L; Boutigny, D; Bowerman, D A; Boyarski, A M; Boyd, J T; Bozzi, C; Brandenburg, G; Brandt, T; Brau, J E; Breon, A B; Brose, J; Brown, C L; Brown, C M; Brown, D N; Bruinsma, M; Brunet, S; Bucci, F; Buchanan, C; Buchmüller, O L; Bugg, W; Bukin, A D; Bula, R; Bulten, H; Burchat, P R; Burke, J P; Button-Shafer, J; Buzzo, A; Bóna, M; Cahn, R N; Calabrese, R; Calcaterra, A; Calderini, G; Campagnari, C; Capra, R; Carpinelli, M; Cartaro, C; Cavallo, N; Cavoto, G; Cenci, R; Chai, X; Chaisanguanthum, K S; Chao, M; Charles, E; Charles, M J; Chauveau, J; Chavez, C A; Chen, A; Chen, C; Chen, E; Chen, J C; Chen, S; Chen, X; Cheng, B; Cheng, C H; Chia, Y M; Cibinetto, G; Clark, P J; Claus, R; Cochran, J; Coleman, J P; Contri, R; Convery, M R; Cossutti, F; Cottingham, W N; Couderc, F; Covarelli, R; Cowan, G; Cowan, R; Crawley, H B; Cremaldi, L; Cristinziani, M; Cunha, A; Curry, S; Côté, D; D'Orazio, A; Dahmes, B; Dallapiccola, C; Danielson, N; Dasu, S; Datta, M; Dauncey, P D; David, P; Davier, M; Davis, C L; Day, C T; De Groot, N; De Nardo, Gallieno; De Sangro, R; Del Buono, L; Del Re, D; Della Ricca, G; Di Lodovico, F; Di Marco, E; Dickopp, M; Dingfelder, J C; Dittongo, S; Dong, D; Dong, L; Dorfan, J; Druzhinin, V P; Dubitzky, R S; Dubois-Felsmann, G P; Dujmic, D; Dunwoodie, W M; Dvoretskii, A; Eckhart, E A; Eckmann, R; Edgar, C L; Edwards, A J; Egede, U; Eichenbaum, A M; Eigen, G; Eisner, A M; Elmer, P; Emery, S; Ernst, J A; Eschenburg, V; Eschrich, I; Eyges, V; Fabozzi, F; Faccini, R; Fan, S; Feltresi, E; Ferrarotto, F; Ferroni, F; Field, R C; Finocchiaro, G; Flacco, C J; Flack, R L; Flächer, H U; Flood, K T; Ford, K E; Ford, W T; Forster, I J; Forti, F; Fortin, D; Foulkes, S D; Franek, B; Frey, R; Fritsch, M; Fry, J R; Fulsom, B G; Gabathuler, E; Gaidot, A; Gaillard, J R; Galeazzi, F; Gallo, F; Gamba, D; Gamet, R; Gan, K K; Ganzhur, S F; Gary, J W; Gaspero, M; Gatto, C; George, K A; Gill, M S; Giorgi, M A; Giroux, X; Gladney, L; Glanzman, T; Godang, R; Goetzen, K; Golubev, V B; Gopal, G P; Gowdy, S J; Gradl, W; Graham, M T; Grancagnolo, S; Graugès-Pous, E; Graziani, G; Green, M G; Grenier, P; Gritsan, A V; Grosdidier, G; Groysman, Y; Guo, Q H; Hadavand, H K; Hadig, T; Haire, M; Halyo, V; Hamano, K; Hamel de Monchenault, G; Hamon, O; Harrison, P F; Harrison, T J; Hart, A J; Hartfiel, B L; Hast, C; Hauke, A; Hawkes, C M; Hearty, C; Held, T; Hertzbach, S S; Heusch, C A; Hill, E J; Hirschauer, J F; Hitlin, D G; Hodgkinson, M C; Hollar, J J; Hong, T M; Honscheid, K; Hopkins, D A; Hrynóva, T; Hufnagel, D; Hulsbergen, W D; Hutchcroft, D E; Höcker, A; Igonkina, O; Innes, W R; Izen, J M; Jackson, P D; Jackson, P S; Jacobsen, R G; Jawahery, A; Jessop, C P; John, M J J; Johnson, J R; Judd, D; Kadel, R W; Kadyk, J; Kagan, H; Karyotakis, Yu; Kass, R; Kelly, M P; Kelsey, M H; Kerth, L T; Khan, A; Kim, H; Kim, P; Kirkby, D; Kitayama, I; Klose, V; Knecht, N S; Koch, H; Kocian, M L; Koeneke, K; Kofler, R; Kolomensky, Yu G; Kovalskyi, D; Kowalewski, R V; Kozanecki, Witold; Kravchenko, E A; Kreisel, A; Krishnamurthy, M; Kroeger, R; Kroseberg, J; Kukartsev, G; Kutter, P E; Kyberd, P; La Vaissière, C de; Lacker, H M; Lae, C K; Lafferty, G D; Lanceri, L; Lange, D J; Langenegger, U; Lankford, A J; Latham, T E; Latour, E; Lau, Y P; Lazzaro, A; Le Diberder, F R; Lees, J P; Legendre, M; Leith, D W G S; Lepeltier, V; Leruste, P; Lewandowski, B; Li Gioi, L; Li, H; Li, X; Libby, J; Lista, L; Liu, R; Lo Vetere, M; LoSecco, J M; Lockman, W S; Lombardo, V; London, G W; Long, O; Lou, X C; Lu, M; Luitz, S; Lund, P; Luppi, E; Lusiani, A; Lutz, A M; Lynch, G; Lynch, H L; Lü, C; Lüth, V; MacFarlane, D B; Macri, M M; Mader, W F; Majewski, S A; Malcles, J; Mallik, U; Mancinelli, G; Mandelkern, M A; Marchiori, G; Margoni, M; Marks, J; Marsiske, H; Martínez-Vidal, F; Mattison, T S; Mayer, B; Mazur, M A; Mazzoni, M A; McKenna, J A; McMahon, T R; Meadows, B T; Mellado, B; Menges, W; Messner, R; Meyer, W T; Mihályi, A; Minamora, J S; Mir, L M; Mohanty, G B; Mohapatra, A K; Mommsen, R K; Monge, M R; Monorchio, D; Moore, T B; Morandin, M; Morgan, S E; Morganti, M; Morganti, S; Morii, M; Muheim, F

    2007-01-01T23:59:59.000Z

    We measure the branching ratios of the Cabibbo-suppressed decays $\\Lambda^+_c$ $\\to$ $\\Lambda$ $K^+$ and $\\Lambda^+_c$ $\\to$ $\\Sigma^{0}$ $K^+$ %(measured with improved accuracy). relative to the Cabibbo-favored decay modes $\\Lambda^+_c$ $\\to$ $\\Lambda$ $\\pi^+$ and $\\Lambda^+_c$ $\\to$ $\\Sigma^{0}$ $\\pi^+$ to be $ 0.044 \\pm 0.004 ~(\\textnormal{stat.})~ \\pm ~0.003 \\~(\\textnormal{syst.})$ and $ 0.039~ \\pm ~0.005 ~(\\textnormal{stat.})~ \\pm \\~0.003 ~(\\textnormal{syst.})$, respectively. We set an upper limit on the branching ratio at 90 % confidence level for $\\Lambda^+_c$ $\\to$ $\\Lambda$ $K^+ \\pi^+ \\pi^-$ to be $ 4.1 \\times ~10^{-2}$ relative to $\\Lambda^+_c$ $\\to$ $\\Lambda$ $\\pi^+$ and for $\\Lambda^+_c$ $\\to$ $\\Sigma^{0}$ $K^+ \\pi^+ \\pi^-$ to be $ 2.0 \\times ~10^{-2}$ relative to $\\Lambda^+_c$ $\\to$ $\\Sigma^{0}$ $\\pi^+$. We also measure the branching fraction for the Cabibbo-favored mode $\\Lambda^+_c$ $\\to$ $\\Sigma^{0}$ $\\pi^+$ relative to $\\Lambda^+_c$ $\\to$ $\\Lambda$ $\\pi^+$ to be $0.977~ \\pm ~0.015 ~(\\textnorm...

  20. Suppression of electric and magnetic fluctuations and improvement of confinement due to current profile modification by biased electrode in Saha Institute of Nuclear Physics tokamak

    SciTech Connect (OSTI)

    Basu, Debjyoti; Pal, Rabindranath [Saha Institute of Nuclear Physics, 1/AF-Bidhannagar, Kolkata 700064 (India); Ghosh, Joydeep; Chattopadhyay, Prabal K. [Institute for Plasma Research, Bhat, Gandhinagar 382428 (India)

    2012-07-15T23:59:59.000Z

    Improvement of plasma confinement is achieved in normal q{sub a} discharges of SINP-tokamak by introducing a biased electrode inside the last closed flux surface. All the important features of high confinement mode are observed biasing the electrode negatively with respect to the vacuum vessel. Arrays of electric and magnetic probes introduced in the edge plasma region reveal suppression of electric and magnetic fluctuations over distinct frequency ranges as well as modification of the toroidal current profile due to biasing. Further analysis identifies the electrostatic fluctuations to be due to drift mode and the magnetic fluctuations may be of slow compressional Alfven waves. Both get suppressed due to current profile modification during biasing, hence leading to the improvement of plasma confinement.

  1. Pressure Effect on the Structural Transition and Suppression of the High-Spin State in the Triple-Layer T'-La?Ni?O?

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Cheng, J.-G.; Zhou, J.-S.; Goodenough, J. B.; Zhou, H. D.; Matsubayashi, K.; Uwatoko, Y.; Kong, P. P.; Jin, C. Q.; Yang, W. G.; Shen, G. Y.

    2012-06-01T23:59:59.000Z

    We report a comprehensive high-pressure study on the triple-layer T'-La?Ni?O? with a suite of experimental probes, including structure determination, magnetic, and transport properties up to 50 GPa. Consistent with a recent ab inito calculation, application of hydrostatic pressure suppresses an insulator-metal spin-state transition at Pc?6 GPa. However, a low-spin metallic phase does not emerge after the high-spin state is suppressed to the lowest temperature. For P>20 GPa, the ambient T' structure transforms gradually to a T†-type structure, which involves a structural reconstruction from fluorite La–O?–La blocks under low pressures to rock-salt LaO-LaO blocks under high pressures. Absence of the metallic phase under pressure has been discussed in terms of local displacements of O²? ions in the fluorite block under pressure before a global T† phase is established.

  2. Suppression of high transverse momentum D mesons in central Pb--Pb collisions at $\\sqrt{s_{NN}}=2.76$ TeV

    E-Print Network [OSTI]

    ALICE Collaboration; B. Abelev; J. Adam; D. Adamová; A. M. Adare; M. M. Aggarwal; G. Aglieri Rinella; A. G. Agocs; A. Agostinelli; S. Aguilar Salazar; Z. Ahammed; N. Ahmad; A. Ahmad Masoodi; S. U. Ahn; A. Akindinov; D. Aleksandrov; B. Alessandro; R. Alfaro Molina; A. Alici; A. Alkin; E. Almaráz Aviña; J. Alme; T. Alt; V. Altini; S. Altinpinar; I. Altsybeev; C. Andrei; A. Andronic; V. Anguelov; J. Anielski; C. Anson; T. Anticic; F. Antinori; P. Antonioli; L. Aphecetche; H. Appelshäuser; N. Arbor; S. Arcelli; A. Arend; N. Armesto; R. Arnaldi; T. Aronsson; I. C. Arsene; M. Arslandok; A. Asryan; A. Augustinus; R. Averbeck; T. C. Awes; J. Äystö; M. D. Azmi; M. Bach; A. Badalà; Y. W. Baek; R. Bailhache; R. Bala; R. Baldini Ferroli; A. Baldisseri; A. Baldit; F. Baltasar Dos Santos Pedrosa; J. Bán; R. C. Baral; R. Barbera; F. Barile; G. G. Barnaföldi; L. S. Barnby; V. Barret; J. Bartke; M. Basile; N. Bastid; S. Basu; B. Bathen; G. Batigne; B. Batyunya; C. Baumann; I. G. Bearden; H. Beck; I. Belikov; F. Bellini; R. Bellwied; E. Belmont-Moreno; G. Bencedi; S. Beole; I. Berceanu; A. Bercuci; Y. Berdnikov; D. Berenyi; D. Berzano; L. Betev; A. Bhasin; A. K. Bhati; J. Bhom; N. Bianchi; L. Bianchi; C. Bianchin; J. Bielcík; J. Bielcíková; A. Bilandzic; S. Bjelogrlic; F. Blanco; F. Blanco; D. Blau; C. Blume; M. Boccioli; N. Bock; A. Bogdanov; H. Bøggild; M. Bogolyubsky; L. Boldizsár; M. Bombara; J. Book; H. Borel; A. Borissov; S. Bose; F. Bossú; M. Botje; S. Böttger; B. Boyer; E. Braidot; P. Braun-Munzinger; M. Bregant; T. Breitner; T. A. Browning; M. Broz; R. Brun; E. Bruna; G. E. Bruno; D. Budnikov; H. Buesching; S. Bufalino; K. Bugaiev; O. Busch; Z. Buthelezi; D. Caballero Orduna; D. Caffarri; X. Cai; H. Caines; E. Calvo Villar; P. Camerini; V. Canoa Roman; G. Cara Romeo; W. Carena; F. Carena; N. Carlin Filho; F. Carminati; C. A. Carrillo Montoya; A. Casanova Díaz; J. Castillo Castellanos; J. F. Castillo Hernandez; E. A. R. Casula; V. Catanescu; C. Cavicchioli; C. Ceballos Sanchez; J. Cepila; P. Cerello; B. Chang; S. Chapeland; J. L. Charvet; S. Chattopadhyay; S. Chattopadhyay; I. Chawla; M. Cherney; C. Cheshkov; B. Cheynis; V. Chibante Barroso; D. D. Chinellato; P. Chochula; M. Chojnacki; S. Choudhury; P. Christakoglou; C. H. Christensen; P. Christiansen; T. Chujo; S. U. Chung; C. Cicalo; L. Cifarelli; F. Cindolo; J. Cleymans; F. Coccetti; F. Colamaria; D. Colella; G. Conesa Balbastre; Z. Conesa del Valle; P. Constantin; G. Contin; J. G. Contreras; T. M. Cormier; Y. Corrales Morales; P. Cortese; I. Cortés Maldonado; M. R. Cosentino; F. Costa; M. E. Cotallo; E. Crescio; P. Crochet; E. Cruz Alaniz; E. Cuautle; L. Cunqueiro; A. Dainese; H. H. Dalsgaard; A. Danu; K. Das; I. Das; D. Das; A. Dash; S. Dash; S. De; G. O. V. de Barros; A. De Caro; G. de Cataldo; J. de Cuveland; A. De Falco; D. De Gruttola; H. Delagrange; E. Del Castillo Sanchez; A. Deloff; V. Demanov; N. De Marco; E. Dénes; S. De Pasquale; A. Deppman; G. D Erasmo; R. de Rooij; M. A. Diaz Corchero; D. Di Bari; T. Dietel; C. Di Giglio; S. Di Liberto; A. Di Mauro; P. Di Nezza; R. Divià; Ø. Djuvsland; A. Dobrin; T. Dobrowolski; I. Domínguez; B. Dönigus; O. Dordic; O. Driga; A. K. Dubey; L. Ducroux; P. Dupieux; A. K. Dutta Majumdar; M. R. Dutta Majumdar; D. Elia; D. Emschermann; H. Engel; H. A. Erdal; B. Espagnon; M. Estienne; S. Esumi; D. Evans; G. Eyyubova; D. Fabris; J. Faivre; D. Falchieri; A. Fantoni; M. Fasel; R. Fearick; A. Fedunov; D. Fehlker; L. Feldkamp; D. Felea; B. Fenton-Olsen; G. Feofilov; A. Fernández Téllez; A. Ferretti; R. Ferretti; J. Figiel; M. A. S. Figueredo; S. Filchagin; D. Finogeev; F. M. Fionda; E. M. Fiore; M. Floris; S. Foertsch; P. Foka; S. Fokin; E. Fragiacomo; M. Fragkiadakis; U. Frankenfeld; U. Fuchs; C. Furget; M. Fusco Girard; J. J. Gaardhøje; M. Gagliardi; A. Gago; M. Gallio; D. R. Gangadharan; P. Ganoti; C. Garabatos; E. Garcia-Solis; I. Garishvili; J. Gerhard; M. Germain; C. Geuna; M. Gheata; A. Gheata; B. Ghidini; P. Ghosh; P. Gianotti; M. R. Girard; P. Giubellino; E. Gladysz-Dziadus; P. Glässel; R. Gomez; E. G. Ferreiro; L. H. González-Trueba; P. González-Zamora; S. Gorbunov; A. Goswami; S. Gotovac; V. Grabski; L. K. Graczykowski; R. Grajcarek; A. Grelli; C. Grigoras; A. Grigoras; V. Grigoriev; S. Grigoryan; A. Grigoryan; B. Grinyov; N. Grion; P. Gros; J. F. Grosse-Oetringhaus; J. -Y. Grossiord; R. Grosso; F. Guber; R. Guernane; C. Guerra Gutierrez; B. Guerzoni; M. Guilbaud; K. Gulbrandsen; T. Gunji; R. Gupta; A. Gupta; H. Gutbrod; Ø. Haaland; C. Hadjidakis; M. Haiduc; H. Hamagaki; G. Hamar; B. H. Han; L. D. Hanratty; A. Hansen; Z. Harmanova; J. W. Harris; M. Hartig; D. Hasegan; D. Hatzifotiadou; A. Hayrapetyan; S. T. Heckel; M. Heide; H. Helstrup; A. Herghelegiu; G. Herrera Corral; N. Herrmann; K. F. Hetland

    2012-10-12T23:59:59.000Z

    The production of the prompt charm mesons $D^0$, $D^+$, $D^{*+}$, and their antiparticles, was measured with the ALICE detector in Pb-Pb collisions at the LHC, at a centre-of-mass energy $\\sqrt{s_{NN}}=2.76$ TeV per nucleon--nucleon collision. The $\\pt$-differential production yields in the range $2suppression by a factor 3-4, for transverse momenta larger than 5 GeV/c in the 20% most central collisions. The suppression is reduced for peripheral collisions.

  3. Pressure Effect on the Structural Transition and Suppression of the High-Spin State in the Triple-Layer T'-La?Ni?O?

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Cheng, J.-G.; Zhou, J.-S.; Goodenough, J. B.; Zhou, H. D.; Matsubayashi, K.; Uwatoko, Y.; Kong, P. P.; Jin, C. Q.; Yang, W. G.; Shen, G. Y.

    2012-06-01T23:59:59.000Z

    We report a comprehensive high-pressure study on the triple-layer T'-La?Ni?O? with a suite of experimental probes, including structure determination, magnetic, and transport properties up to 50 GPa. Consistent with a recent ab inito calculation, application of hydrostatic pressure suppresses an insulator-metal spin-state transition at Pc?6 GPa. However, a low-spin metallic phase does not emerge after the high-spin state is suppressed to the lowest temperature. For P>20 GPa, the ambient T' structure transforms gradually to a T†-type structure, which involves a structural reconstruction from fluorite La–O?–La blocks under low pressures to rock-salt LaO-LaO blocks under high pressures. Absence of the metallicmore »phase under pressure has been discussed in terms of local displacements of O²? ions in the fluorite block under pressure before a global T† phase is established.« less

  4. D{sup 0}-{anti D}{sup 0} mixing and doubly Cabibbo-suppressed decays of the D{sup +}

    SciTech Connect (OSTI)

    Fermilab E791 Collaboration

    1994-07-01T23:59:59.000Z

    This report summarizes results from Fermilab experiment E791 on D{sup 0}-{anti D}{sup 0} mixing and doubly Cabibbo-suppressed decays of the D{sup +} meson. In order to search for D{sup 0}-{anti D}{sup 0} mixing, the authors use only D{sup 0} mesons from D{sup *+} decays in which case the charge of the pion from the D{sup *+} decay identifies the charm quantum number of the D{sup 0} at birth. When the D{sup 0} decays, the charge of the kaon identifies the charm quantum number and this way one can tell if mixing has occurred. This kind of search can be carried out by CLEO II as well and their conclusion was that there is some evidence of a wrong sign signal (0.77 {+-} 0.25 {+-} 0.25)% of the right sign signal. However, because of a lack of lifetime information, they cannot distinguish between doubly Cabibbo-suppressed decays which are expected at the level of the observed signal and mixing. They use their excellent lifetime sensitivity to obtain separate limits. During the past year, the authors have been working on extracting D{sup +} doubly Cabibbo-suppressed decay signals from E791`s data sample. These decays are interesting both because they have never been observed and because definite predictions have been made about their rates, based on models of D mesons and their decay mechanisms. Preliminary analyses of 1/3 of the data have now been completed. Figure 3 shows the Cabibbo-favored signal D{sup +} {yields} K{sup {minus}}{pi}{sup +}{pi}{sup +} and the next figure shows the signal in the doubly Cabibbo-suppressed mode D{sup +} {yields} K{sup +}{pi}{sup {minus}}{pi}{sup {minus}}.

  5. InGaN/GaN multiple-quantum-well light-emitting diodes with a grading InN composition suppressing the Auger recombination

    E-Print Network [OSTI]

    Demir, Hilmi Volkan

    InGaN/GaN multiple-quantum-well light-emitting diodes with a grading InN composition suppressing://scitation.aip.org/content/aip/journal/apl/105/3?ver=pdfcov Published by the AIP Publishing Articles you may be interested in High efficiency InGaN/GaN (2014); 10.1063/1.4867023 Effect of V-defects on the performance deterioration of InGaN/GaN multiple

  6. Suppression of fine-structure splitting and oscillator strength of sodium D-line in a Debye plasma

    SciTech Connect (OSTI)

    Basu, Joyee, E-mail: joyeebasu@yahoo.com; Ray, Debasis, E-mail: ray.debasis@gmail.com [Department of Physics, Bengal Engineering and Science University, Shibpur, Howrah, West Bengal 711 103 (India)] [Department of Physics, Bengal Engineering and Science University, Shibpur, Howrah, West Bengal 711 103 (India)

    2014-01-15T23:59:59.000Z

    We investigate theoretically the influence of static plasma screening on relativistic spin-orbit interaction-induced fine-structure splitting of the D-line doublet arising from the transitions 3p{sub 1/2}–3s{sub 1/2} and 3p{sub 3/2}–3s{sub 1/2} of the valence electron of a sodium atom embedded in a model plasma environment. The many-electron atomic problem is formulated first as an effective one-electron problem in which the interaction between the optically active valence electron and the atomic ion core is represented by an accurate parametric model potential including core-polarization correction, and then the plasma effect on the atomic system is simulated by the Debye-screening model for the valence-core interaction. It is observed that the magnitude of spin-orbit energy shift reduces for both the upper component 3p{sub 3/2} and the lower component 3p{sub 1/2} with increasing plasma screening strength, thereby reducing the spin-orbit energy separation between these two components as the screening becomes stronger. As a consequence, the magnitude of fine-structure splitting between the D{sub 1} and D{sub 2} line energies of sodium drops significantly with stronger plasma screening. The optical (absorption) oscillator strength for 3s ? 3p transition is seen to reduce with stronger screening and this leads to a screening-induced gradual suppression of the 3p ? 3s spontaneous decay rate.

  7. MRP4 knockdown enhances migration, suppresses apoptosis, and produces aggregated morphology in human retinal vascular endothelial cells

    SciTech Connect (OSTI)

    Tagami, Mizuki [Department of Surgery Related, Division of Ophthalmology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017 (Japan)] [Department of Surgery Related, Division of Ophthalmology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017 (Japan); Kusuhara, Sentaro, E-mail: kusu@med.kobe-u.ac.jp [Department of Surgery Related, Division of Ophthalmology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017 (Japan)] [Department of Surgery Related, Division of Ophthalmology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017 (Japan); Imai, Hisanori [Department of Surgery Related, Division of Ophthalmology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017 (Japan)] [Department of Surgery Related, Division of Ophthalmology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017 (Japan); Uemura, Akiyoshi [Department of Surgery Related, Division of Ophthalmology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017 (Japan) [Department of Surgery Related, Division of Ophthalmology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017 (Japan); Department of Vascular Biology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017 (Japan); Honda, Shigeru; Tsukahara, Yasutomo; Negi, Akira [Department of Surgery Related, Division of Ophthalmology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017 (Japan)] [Department of Surgery Related, Division of Ophthalmology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017 (Japan)

    2010-10-01T23:59:59.000Z

    Research highlights: {yields} Exogenous VEGF decreases MRP4 expression in a dose-dependent manner. {yields} MRP4 knockdown leads to enhanced cell migration. {yields} MRP4 knockdown suppresses caspase-3-mediated cell apoptosis. {yields} MRP4 knockdown produces cell assembly and cell aggregation. -- Abstract: The multidrug resistance protein (MRP) MRP4/ABCC4 is an ATP-binding cassette transporter that actively effluxes endogenous and xenobiotic substrates out of cells. In the rodent retina, Mrp4 mRNA and protein are exclusively expressed in vascular endothelial cells, but the angiogenic properties of Mrp4 are poorly understood so far. This study aims to explore the angiogenic properties of MRP4 in human retinal microvascular endothelial cells (HRECs) utilizing the RNA interference (RNAi) technique. MRP4 expression was decreased at the mRNA and protein levels after stimulation with exogenous vascular endothelial growth factor in a dose-dependent manner. RNAi-mediated MRP4 knockdown in HRECs do not affect cell proliferation but enhances cell migration. Moreover, cell apoptosis induced by serum starvation was less prominent in MRP4 siRNA-treated HRECs as compared to control siRNA-treated HRECs. In a Matrigel-based tube-formation assay, although MRP4 knockdown did not lead to a significant change in the total tube length, MRP4 siRNA-treated HRECs assembled and aggregated into a massive tube-like structure, which was not observed in control siRNA-treated HRECs. These results suggest that MRP4 is uniquely involved in retinal angiogenesis.

  8. MicroRNA-320a suppresses human colon cancer cell proliferation by directly targeting {beta}-catenin

    SciTech Connect (OSTI)

    Sun, Jian-Yong [State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, 710032 Xi'an (China) [State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, 710032 Xi'an (China); State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 710032 Xi'an (China); Huang, Yi [Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, 710032 Xi'an (China)] [Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, 710032 Xi'an (China); Li, Ji-Peng [State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 710032 Xi'an (China)] [State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 710032 Xi'an (China); Zhang, Xiang; Wang, Lei [State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, 710032 Xi'an (China)] [State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, 710032 Xi'an (China); Meng, Yan-Ling [Department of Immunology, Fourth Military Medical University, 710032 Xi'an (China)] [Department of Immunology, Fourth Military Medical University, 710032 Xi'an (China); Yan, Bo [State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, 710032 Xi'an (China)] [State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, 710032 Xi'an (China); Bian, Yong-Qian [State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 710032 Xi'an (China)] [State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 710032 Xi'an (China); Zhao, Jing [State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, 710032 Xi'an (China)] [State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, 710032 Xi'an (China); Wang, Wei-Zhong, E-mail: weichang@fmmu.edu.cn [State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 710032 Xi'an (China)] [State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 710032 Xi'an (China); and others

    2012-04-20T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer miR-320a is downregulated in human colorectal carcinoma. Black-Right-Pointing-Pointer Overexpression of miR-320a inhibits colon cancer cell proliferation. Black-Right-Pointing-Pointer {beta}-Catenin is a direct target of miR-320a in colon cancer cells. Black-Right-Pointing-Pointer miR-320a expression inversely correlates with mRNA expression of {beta}-catenin's target genes in human colon carcinoma. -- Abstract: Recent profile studies of microRNA (miRNA) expression have documented a deregulation of miRNA (miR-320a) in human colorectal carcinoma. However, its expression pattern and underlying mechanisms in the development and progression of colorectal carcinoma has not been elucidated clearly. Here, we performed real-time PCR to examine the expression levels of miR-320a in colon cancer cell lines and tumor tissues. And then, we investigated its biological functions in colon cancer cells by a gain of functional strategy. Further more, by the combinational approaches of bioinformatics and experimental validation, we confirmed target associations of miR-320a in colorectal carcinoma. Our results showed that miR-320a was frequently downregulated in cancer cell lines and colon cancer tissues. And we demonstrated that miR-320a restoration inhibited colon cancer cell proliferation and {beta}-catenin, a functionally oncogenic molecule was a direct target gene of miR-320a. Finally, the data of real-time PCR showed the reciprocal relationship between miR-320a and {beta}-catenin's downstream genes in colon cancer tissues. These findings indicate that miR-320a suppresses the growth of colon cancer cells by directly targeting {beta}-catenin, suggesting its application in prognosis prediction and cancer treatment.

  9. Change of caged dynamics at Tg in hydrated proteins found after suppressing the methyl-group rotation contribution

    E-Print Network [OSTI]

    K. L. Ngai; S. Capaccioli; A. Paciaroni

    2011-06-29T23:59:59.000Z

    In conventional glassformers at sufficiently short times and low enough temperatures, molecules are mutually caged by the intermolecular potential. The fluctuation and dissipation from motion of caged molecules when observed by elastic incoherent neutron scattering exhibit a change in temperature dependence of the mean square displacement (MSD) at the glass transition temperature Tg. This is a general and fundamental property of caged dynamics in glassformers, which is observed always near Tg independent of the energy resolution of the spectrometer. Recently we showed the same change of T-dependence at Tg is present in proteins solvated with bioprotectants, coexisting with the dynamic transition at a higher temperature Td. In these solvated proteins, all having Tg and Td higher than the proteins hydrated by water alone, the observation of the change of T-dependence of the MSD at Tg is unobstructed by the methyl-group rotation contribution at lower temperatures. On the other hand, proteins hydrated by water alone have lower Tg and Td, and hence unambiguous evidence of the transition of MSD at Tg is hard to find. Notwithstanding, evidence on the break of the MSD at Tg can be found by deuterating the protein to suppress the methyl-group contribution. An alternative strategy is the use of a spectrometer that senses motions faster than 15 ps, which confers the benefit of shifting both the onset of methyl-group rotation contribution as well as the dynamic transition to higher temperatures, and again the change of MSD at Tg becomes evident. The break of the elastic intensity or the MSD at Tg coexists with the dynamics transition at Td in hydrated and solvated proteins. Recognition of this fact helps to remove inconsistency and conundrum encountered in interpreting the data that thwart progress in understanding the origin of the dynamic transition and its connection to biological function.

  10. Top-Down Suppression

    E-Print Network [OSTI]

    Rissman, JA; Zanto, TP

    2015-01-01T23:59:59.000Z

    cortex contribute to top-down modulation of visual2003). Neural mechanisms of top-down control during spatialC. D. , & Li, W. (2013). Top-down influences on visual

  11. A non-uniform three-gap buncher cavity with suppression of transverse-electromagnetic mode leakage in the triaxial klystron amplifier

    SciTech Connect (OSTI)

    Qi, Zumin; Zhang, Jun, E-mail: zhangjun-nudt@126.com; Zhong, Huihuang; Zhu, Danni; Qiu, Yongfeng [College of Optoelectric Science and Engineering, National University of Defense Technology, Changsha, Hunan 410073 (China)] [College of Optoelectric Science and Engineering, National University of Defense Technology, Changsha, Hunan 410073 (China)

    2014-01-15T23:59:59.000Z

    The triaxial klystron amplifier is an efficient high power relativistic klystron amplifier operating at high frequencies due to its coaxial structure with large radius. However, the coaxial structures result in coupling problems among the cavities as the TEM mode is not cut-off in the coaxial tube. Therefore, the suppression of the TEM mode leakage, especially the leakage from the buncher cavity to the input cavity, is crucial in the design of a triaxial klystron amplifier. In this paper, a non-uniform three-gap buncher cavity is proposed to suppress the TEM mode leakage. The cold cavity analysis shows that the non-uniform three-gap buncher cavity can significantly suppress the TEM mode generation compared to a uniform three-gap buncher cavity. Particle-in-cell simulation shows that the power leakage to the input cavity is less than 1.5‰ of the negative power in the buncher cavity and the buncher cavity can efficiently modulate an intense relativistic electron beam free of self-oscillations. A fundamental current modulation depth of 117% is achieved by employing the proposed non-uniform buncher cavity into an X-band triaxial amplifier, which results in the high efficiency generation of high power microwave.

  12. Measurements of branching fraction ratios and CP-asymmetries in suppressed B-? D(? K+?-)K- and B-? D(? K+?-)?- decays

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Aaltonen, T. [Helsinki Inst. of Physics; Gonzalez, Alvarez B. [Oviedo U., Cantabria Inst. of Phys.; Amerio, S. [INFN, Padua; Amidei, D. [Michigan U.; Anastassov, A. [Northwestern U.; Annovi, A. [Frascati; Antos, J [Comenius U.; Apollinari, G. [Fermilab; Appel, J. A [Fermilab; Apresyan, A. [Purdue; Arisawa, T. [Waseda U., Dubna, JINR

    2011-08-01T23:59:59.000Z

    We report the first reconstruction in hadron collisions of the suppressed decays B-? D(? K+?-)K- and B-? D(? K+?-)?- decays, sensitive to the CKM phase {gamma}, using data from 7 fb-1 of integrated luminosity collected by the CDF II detector at the Tevatron collider. We reconstruct a signal for the B-? D(? K+?-)K- suppressed mode with a significance of 3.2 standard deviations, and measure the ratios of the suppressed to favored branching fractions R(K) = [22.0 ± 8.6(stat) ± 2.6(syst)] x 10-3, R+(K) = [42.6 ± 13.7(stat) ± 2.8(syst)] x 10-3, R-(K) = [3.8 ± 10.3(stat) ± 2.7(syst)] x 10-3 as well as the direct CP-violating asymmetry A(K) = -0.82±0.44(stat)±0.09(syst) of this mode. Corresponding quantities for B- ? D(? K+?-)?- decay are also reported.

  13. SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of {beta}-catenin

    SciTech Connect (OSTI)

    Cho, Il-Rae [WCU, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 609-735 (Korea, Republic of)] [WCU, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 609-735 (Korea, Republic of); Koh, Sang Seok [Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333 (Korea, Republic of) [Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333 (Korea, Republic of); Department of Functional Genomics, University of Science and Technology, Daejeon 305-333 (Korea, Republic of); Malilas, Waraporn; Srisuttee, Ratakorn; Moon, Jeong [WCU, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 609-735 (Korea, Republic of)] [WCU, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 609-735 (Korea, Republic of); Choi, Young-Whan [Department of Horticultural Bioscience, Pusan National University, Miryang 627-706 (Korea, Republic of)] [Department of Horticultural Bioscience, Pusan National University, Miryang 627-706 (Korea, Republic of); Horio, Yoshiyuki [Department of Pharmacology, Sapporo Medical University, Sapporo 060-8556 (Japan)] [Department of Pharmacology, Sapporo Medical University, Sapporo 060-8556 (Japan); Oh, Sangtaek [Department of Advanced Fermentation Fusion Science and Technology, Kookmin University, Seoul 136-702 (Korea, Republic of)] [Department of Advanced Fermentation Fusion Science and Technology, Kookmin University, Seoul 136-702 (Korea, Republic of); Chung, Young-Hwa, E-mail: younghc@pusan.ac.kr [WCU, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 609-735 (Korea, Republic of)] [WCU, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 609-735 (Korea, Republic of)

    2012-06-29T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer SIRT1 inhibits protein levels of {beta}-catenin and its transcriptional activity. Black-Right-Pointing-Pointer Nuclear localization of SIRT1 is not required for the decrease of {beta}-catenin expression. Black-Right-Pointing-Pointer SIRT1-mediated degradation of {beta}-catenin is not required for GSK-3{beta} and Siah-1 but for proteosome. Black-Right-Pointing-Pointer SIRT1 activation inhibits proliferation of pancreatic cancer cells expressing PAUF. -- Abstract: Because we found in a recent study that pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, induces a rapid proliferation of pancreatic cells by up-regulation of {beta}-catenin, we postulated that {beta}-catenin might be a target molecule for pancreatic cancer treatment. We thus speculated whether SIRT1, known to target {beta}-catenin in a colon cancer model, suppresses {beta}-catenin in those pancreatic cancer cells that express PAUF (Panc-PAUF). We further evaluated whether such suppression would lead to inhibition of the proliferation of these cells. The ectopic expression of either SIRT1 or resveratrol (an activator of SIRT1) suppressed levels of {beta}-catenin protein and its transcriptional activity in Panc-PAUF cells. Conversely, suppression of SIRT1 expression by siRNA enhanced {beta}-catenin expression and transcriptional activity. SIRT1 mutant analysis showed that nuclear localization of SIRT1 is not required for reduction of {beta}-catenin. Treatment with MG132, a proteasomal inhibitor, restored {beta}-catenin protein levels, suggesting that SIRT1-mediated degradation of {beta}-catenin requires proteasomal activity. It was reported that inhibition of GSK-3{beta} or Siah-1 stabilizes {beta}-catenin in colon cancer cells, but suppression of GSK-3{beta} or Siah-1 using siRNA in the presence of resveratrol instead diminished {beta}-catenin protein levels in Panc-PAUF cells. This suggests that GSK-3{beta} and Siah-1 are not involved in SIRT1-mediated degradation of {beta}-catenin in the cells. Finally, activation of SIRT1 inhibited the proliferation of Panc-PAUF cells by down-regulation of cyclin-D1, a target molecule of {beta}-catenin. These results suggest that SIRT1 activation may be a therapeutic strategy for treatment of pancreatic cancer cells that express PAUF via the down-regulation of {beta}-catenin.

  14. Survey of fire-protection systems at LNG facilities. Topical report, July-November 1990

    SciTech Connect (OSTI)

    Atallah, S.; Borows, K.A.

    1991-04-05T23:59:59.000Z

    The objectives of the study were to collect and analyze data relating to the types, costs, and operational problems of gas leak and fire detection devices and of fire prevention and suppression systems used at LNG facilities operating in the United States. Data from 39 LNG facilities, which accounted for 45% of the total U.S. storage capacity, were collected. The report provides information relating to equipment manufacturers, site applications, operational problems, initial installation costs, annual operational costs, and equipment lifetime. Equipment of interest included fixed gas leak, fire and cryogenic detection systems, water deluge and barrier systems, thermal radiation walls and protective coatings, and fixed high expansion foam, dry chemical, carbon dioxide and halon fire suppression systems. In addition, internal fire fighting capabilities were reviewed.

  15. Pressure Effect on the Structural Transition and Suppression of the High-Spin State in the Triple-Layer T'-La?Ni?O?

    SciTech Connect (OSTI)

    Cheng, J.-G.; Zhou, J.-S.; Goodenough, J. B.; Zhou, H. D.; Matsubayashi, K.; Uwatoko, Y.; Kong, P. P.; Jin, C. Q.; Yang, W. G.; Shen, G. Y.

    2012-06-01T23:59:59.000Z

    We report a comprehensive high-pressure study on the triple-layer T'-La?Ni?O? with a suite of experimental probes, including structure determination, magnetic, and transport properties up to 50 GPa. Consistent with a recent ab inito calculation, application of hydrostatic pressure suppresses an insulator-metal spin-state transition at Pc?6 GPa. However, a low-spin metallic phase does not emerge after the high-spin state is suppressed to the lowest temperature. For P>20 GPa, the ambient T' structure transforms gradually to a T-type structure, which involves a structural reconstruction from fluorite La–O?–La blocks under low pressures to rock-salt LaO-LaO blocks under high pressures. Absence of the metallic phase under pressure has been discussed in terms of local displacements of O²? ions in the fluorite block under pressure before a global T† phase is established.

  16. Ubiquitin carboxyl terminal hydrolase L1 negatively regulates TNF{alpha}-mediated vascular smooth muscle cell proliferation via suppressing ERK activation

    SciTech Connect (OSTI)

    Ichikawa, Tomonaga; Li, Jinqing; Dong, Xiaoyu; Potts, Jay D. [Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29208 (United States)] [Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29208 (United States); Tang, Dong-Qi [Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610-0275 (United States)] [Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610-0275 (United States); Li, Dong-Sheng, E-mail: dsli@yymc.edu.cn [Hubei Key Laboratory of Embryonic Stem Cell Research, Tai He Hospital, Yunyang Medical College, 32 S. Renmin Rd., Shiyan, Hubei 442000 (China)] [Hubei Key Laboratory of Embryonic Stem Cell Research, Tai He Hospital, Yunyang Medical College, 32 S. Renmin Rd., Shiyan, Hubei 442000 (China); Cui, Taixing, E-mail: taixing.cui@uscmed.sc.edu [Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29208 (United States)] [Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29208 (United States)

    2010-01-01T23:59:59.000Z

    Deubiquitinating enzymes (DUBs) appear to be critical regulators of a multitude of processes such as proliferation, apoptosis, differentiation, and inflammation. We have recently demonstrated that a DUB of ubiquitin carboxyl terminal hydrolase L1 (UCH-L1) inhibits vascular lesion formation via suppressing inflammatory responses in vasculature. However, the precise underlying mechanism remains to be defined. Herein, we report that a posttranscriptional up-regulation of UCH-L1 provides a negative feedback to tumor necrosis factor alpha (TNF{alpha})-mediated activation of extracellular signal-regulated kinases (ERK) and proliferation in vascular smooth muscle cells (VSMCs). In rat adult VSMCs, adenoviral over-expression of UCH-L1 inhibited TNF{alpha}-induced activation of ERK and DNA synthesis. In contrast, over-expression of UCH-L1 did not affect platelet derived growth factor (PDGF)-induced VSMC proliferation and activation of growth stimulating cascades including ERK. TNF{alpha} hardly altered UCH-L1 mRNA expression and stability; however, up-regulated UCH-L1 protein expression via increasing UCH-L1 translation. These results uncover a novel mechanism by which UCH-L1 suppresses vascular inflammation.

  17. Tamoxifen inhibits tumor cell invasion and metastasis in mouse melanoma through suppression of PKC/MEK/ERK and PKC/PI3K/Akt pathways

    SciTech Connect (OSTI)

    Matsuoka, Hiroshi [Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi-Osaka 577-8502 (Japan) [Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi-Osaka 577-8502 (Japan); Department of Pharmacy, Nara Hospital, Kinki University School of Medicine, 1248-1 Ikoma, Nara 630-0293 (Japan); Tsubaki, Masanobu [Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi-Osaka 577-8502 (Japan)] [Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi-Osaka 577-8502 (Japan); Yamazoe, Yuzuru [Department of Pharmacy, Kinki University Hospital, Osakasayama, Osaka 589-8511 (Japan)] [Department of Pharmacy, Kinki University Hospital, Osakasayama, Osaka 589-8511 (Japan); Ogaki, Mitsuhiko [Department of Pharmacy, Higahiosaka City General Hospital, Higashi-osaka, Osaka 578-8588 (Japan)] [Department of Pharmacy, Higahiosaka City General Hospital, Higashi-osaka, Osaka 578-8588 (Japan); Satou, Takao; Itoh, Tatsuki [Department of Pathology, Kinki University School of Medicine, Osakasayama, Osaka 589-8511 (Japan)] [Department of Pathology, Kinki University School of Medicine, Osakasayama, Osaka 589-8511 (Japan); Kusunoki, Takashi [Department of Otolaryngology, Juntendo University School of Medicine, Tokyo (Japan)] [Department of Otolaryngology, Juntendo University School of Medicine, Tokyo (Japan); Nishida, Shozo, E-mail: nishida@phar.kindai.ac.jp [Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi-Osaka 577-8502 (Japan)] [Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi-Osaka 577-8502 (Japan)

    2009-07-15T23:59:59.000Z

    In melanoma, several signaling pathways are constitutively activated. Among these, the protein kinase C (PKC) signaling pathways are activated through multiple signal transduction molecules and appear to play major roles in melanoma progression. Recently, it has been reported that tamoxifen, an anti-estrogen reagent, inhibits PKC signaling in estrogen-negative and estrogen-independent cancer cell lines. Thus, we investigated whether tamoxifen inhibited tumor cell invasion and metastasis in mouse melanoma cell line B16BL6. Tamoxifen significantly inhibited lung metastasis, cell migration, and invasion at concentrations that did not show anti-proliferative effects on B16BL6 cells. Tamoxifen also inhibited the mRNA expressions and protein activities of matrix metalloproteinases (MMPs). Furthermore, tamoxifen suppressed phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2) and Akt through the inhibition of PKC{alpha} and PKC{delta} phosphorylation. However, other signal transduction factor, such as p38 mitogen-activated protein kinase (p38MAPK) was unaffected. The results indicate that tamoxifen suppresses the PKC/mitogen-activated protein kinase kinase (MEK)/ERK and PKC/phosphatidylinositol-3 kinase (PI3K)/Akt pathways, thereby inhibiting B16BL6 cell migration, invasion, and metastasis. Moreover, tamoxifen markedly inhibited not only developing but also clinically evident metastasis. These findings suggest that tamoxifen has potential clinical applications for the treatment of tumor cell metastasis.

  18. InGaN/GaN multiple-quantum-well light-emitting diodes with a grading InN composition suppressing the Auger recombination

    SciTech Connect (OSTI)

    Zhang, Zi-Hui; Liu, Wei; Ju, Zhengang; Tan, Swee Tiam; Ji, Yun; Kyaw, Zabu; Zhang, Xueliang; Wang, Liancheng; Sun, Xiao Wei, E-mail: EXWSUN@ntu.edu.sg, E-mail: VOLKAN@stanfordalumni.org [LUMINOUS Centre of Excellence for Semiconductor Lighting and Displays, School of Electrical and Electronic Engineering, School of Physical and Mathematical Sciences, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (Singapore); Demir, Hilmi Volkan, E-mail: EXWSUN@ntu.edu.sg, E-mail: VOLKAN@stanfordalumni.org [LUMINOUS Centre of Excellence for Semiconductor Lighting and Displays, School of Electrical and Electronic Engineering, School of Physical and Mathematical Sciences, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (Singapore); Department of Electrical and Electronics, Department of Physics, and UNAM-Institute of Material Science and Nanotechnology, Bilkent University, TR-06800 Ankara (Turkey)

    2014-07-21T23:59:59.000Z

    In conventional InGaN/GaN light-emitting diodes (LEDs), thin InGaN quantum wells are usually adopted to mitigate the quantum confined Stark effect (QCSE), caused due to strong polarization induced electric field, through spatially confining electrons and holes in small recombination volumes. However, this inevitably increases the carrier density in quantum wells, which in turn aggravates the Auger recombination, since the Auger recombination scales with the third power of the carrier density. As a result, the efficiency droop of the Auger recombination severely limits the LED performance. Here, we proposed and showed wide InGaN quantum wells with the InN composition linearly grading along the growth orientation in LED structures suppressing the Auger recombination and the QCSE simultaneously. Theoretically, the physical mechanisms behind the Auger recombination suppression are also revealed. The proposed LED structure has experimentally demonstrated significant improvement in optical output power and efficiency droop, proving to be an effective solution to this important problem of Auger recombination.

  19. The ARGUS system, developed by Argonne National Laboratory for the U.S. DOE Packaging Certification Program, is the result of extensive hardware and software development. The

    E-Print Network [OSTI]

    Kemner, Ken

    , providing a powerful, customizable platform for full lifecycle materials management during transport

  20. Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties.

    SciTech Connect (OSTI)

    Huang, E. Y.; Madireddi, M. T.; Gopalkrishnan, R. V.; Leszczyniecka, M.; Su, Z. Z.; Lebedeva, I. V.; Kang, D. C.; Jian, H.; Lin, J. J.; Alexandre, D.; Chen, Y.; Vozhilla, N.; Mei, M. X.; Christiansen, K. A.; Sivo, F.; Goldstein, N. I.; Chada, S.; Huberman, E.; Pestka, S.; Fisher, P. B.; Biochip Technology Center; Columbia Univ.; Introgen Therapeutics Inc.; UMDNJ-Robert Wood Johnson Medical School

    2001-10-25T23:59:59.000Z

    Abnormalities in cellular differentiation are frequent occurrences in human cancers. Treatment of human melanoma cells with recombinant fibroblast interferon (IFN-beta) and the protein kinase C activator mezerein (MEZ) results in an irreversible loss in growth potential, suppression of tumorigenic properties and induction of terminal cell differentiation. Subtraction hybridization identified melanoma differentiation associated gene-7 (mda-7), as a gene induced during these physiological changes in human melanoma cells. Ectopic expression of mda-7 by means of a replication defective adenovirus results in growth suppression and induction of apoptosis in a broad spectrum of additional cancers, including melanoma, glioblastoma multiforme, osteosarcoma and carcinomas of the breast, cervix, colon, lung, nasopharynx and prostate. In contrast, no apparent harmful effects occur when mda-7 is expressed in normal epithelial or fibroblast cells. Human clones of mda-7 were isolated and its organization resolved in terms of intron/exon structure and chromosomal localization. Hu-mda-7 encompasses seven exons and six introns and encodes a protein with a predicted size of 23.8 kDa, consisting of 206 amino acids. Hu-mda-7 mRNA is stably expressed in the thymus, spleen and peripheral blood leukocytes. De novo mda-7 mRNA expression is also detected in human melanocytes and expression is inducible in cells of melanocyte/melanoma lineage and in certain normal and cancer cell types following treatment with a combination of IFN-beta plus MEZ. Mda-7 expression is also induced during megakaryocyte differentiation induced in human hematopoietic cells by treatment with TPA (12-O-tetradecanoyl phorbol-13-acetate). In contrast, de novo expression of mda-7 is not detected nor is it inducible by IFN-beta+MEZ in a spectrum of additional normal and cancer cells. No correlation was observed between induction of mda-7 mRNA expression and growth suppression following treatment with IFN-beta+MEZ and induction of endogenous mda-7 mRNA by combination treatment did not result in significant intracellular MDA-7 protein. Radiation hybrid mapping assigned the mda-7 gene to human chromosome 1q, at 1q 32.2 to 1q41, an area containing a cluster of genes associated with the IL-10 family of cytokines. Mda-7 represents a differentiation, growth and apoptosis associated gene with potential utility for the gene-based therapy of diverse human cancers.

  1. A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-?B and Nrf2-Keap1 signaling pathways

    SciTech Connect (OSTI)

    Gan, Fei-Fei; Ling, Hui; Ang, Xiaohui; Reddy, Shridhivya A.; Lee, Stephanie S-H.; Yang, Hong; Tan, Sock-Hoon [Department of Pharmacy, Faculty of Science, National University of Singapore (Singapore); Hayes, John D. [Jacqui Wood Cancer Centre, Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland (United Kingdom); Chui, Wai-Keung [Department of Pharmacy, Faculty of Science, National University of Singapore (Singapore); Chew, Eng-Hui, E-mail: phaceh@nus.edu.sg [Department of Pharmacy, Faculty of Science, National University of Singapore (Singapore)

    2013-11-01T23:59:59.000Z

    Natural compounds containing vanilloid and Michael acceptor moieties appear to possess anti-cancer and chemopreventive properties. The ginger constituent shogaol represents one such compound. In this study, the anti-cancer potential of a synthetic novel shogaol analog 3-phenyl-3-shogaol (3-Ph-3-SG) was assessed by evaluating its effects on signaling pathways. At non-toxic concentrations, 3-Ph-3-SG suppressed cancer cell invasion in MDA-MB-231 and MCF-7 breast carcinoma cells through inhibition of PMA-activated MMP-9 expression. At similar concentrations, 3-Ph-3-SG reduced expression of the inflammatory mediators nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and prostanglandin-E{sub 2} (PGE{sub 2}) in RAW 264.7 macrophage-like cells. Inhibition of cancer cell invasion and inflammation by 3-Ph-3-SG were mediated through suppression of the nuclear factor-kappaB (NF-?B) signaling pathway. The 3-Ph-3-SG also demonstrated cytoprotective effects by inducing the antioxidant response element (ARE)-driven genes NAD(P)H quinone oxidoreductase-1 (NQO1) and heme oxygenase-1 (HO-1). Cytoprotection by 3-Ph-3-SG was achieved at least partly through modification of cysteine residues in the E3 ubiquitin ligase substrate adaptor Kelch-like ECH-associated protein 1 (Keap1), which resulted in accumulation of transcription factor NF-E2 p45-related factor 2 (Nrf2). The activities of 3-Ph-3-SG were comparable to those of 6-shogaol, the most abundant naturally-occurring shogaol, and stronger than those of 4-hydroxyl-null deshydroxy-3-phenyl-3-shogaol, which attested the importance of the 4-hydroxy substituent in the vanilloid moiety for bioactivity. In summary, 3-Ph-3-SG is shown to possess activities that modulate stress-associated pathways relevant to multiple steps in carcinogenesis. Therefore, it warrants further investigation of this compound as a promising candidate for use in chemotherapeutic and chemopreventive strategies. - Highlights: • Novel shogaol 3-phenyl-3-shogaol suppressed cancer cell invasion and inflammation. • Anti-invasive and anti-inflammatory effects were NF-?B-dependent. • 3-Phenyl-3-shogaol induced ARE-driven genes to achieve cytoprotection. • Cytoprotective effects were brought about by modification of cysteines in Keap1. • Chemopreventive activities of 3-phenyl-3-shogaol and 6-shogaol were comparable.

  2. Scaling patterns for the suppression of charged hadron yields in Pb+Pb collisions at Root_s = 2.76 TeV: Constraints on transport coefficients

    E-Print Network [OSTI]

    Roy A. Lacey; N. N. Ajitanand; J. M. Alexander; J. Jia; A. Taranenko

    2012-02-24T23:59:59.000Z

    Suppression measurements for charged hadrons are used to investigate the path length (L) and transverse momentum (p_T) dependent jet quenching patterns of the hot and dense QCD medium produced in Pb+Pb collisions at Root_s =2.76 TeV at the LHC. The observed scaling patterns, which are similar to those observed for Au+Au collisions at Root_s = 0.20 TeV at RHIC, show the trends predicted for jet-medium interactions dominated by radiative energy loss. They also allow a simple estimate of the transport coefficient $\\hat{q}$, which suggests that the medium produced in LHC collisions is somewhat less opaque than that produced at RHIC, if the same parton-medium coupling strength is assumed. The higher temperature produced in LHC collisions could reduce the parton-medium coupling strength to give identical values for $\\hat{q}$ in LHC and RHIC collisions.

  3. Mechanisms of tolerance in murine radiation bone marrow chimeras. I. Nonspecific suppression of alloreactivity by spleen cells from early, but not late, chimeras

    SciTech Connect (OSTI)

    Auchincloss, H. Jr.; Sachs, D.H.

    1983-10-01T23:59:59.000Z

    Allogeneic chimeras were prepared using lethally irradiated B6 hosts and untreated marrow from exsanguinated BALB/c donors. For about two months after reconstitution, chimeras had very weak antihost cell-mediated lymphocytotoxicity (CML) reactivity and little third-party alloreactivity. During this time a cell population capable of suppressing CML reactivity against both host and third-party alloantigens (i.e., antigen-nonspecific) was demonstrated in chimera spleens by in vitro mixing experiments. The putative suppressor cells were Thy-1-negative and radiation-sensitive. Subsequently, mature chimeras showed host tolerance and strong third-party alloreactivity. At this point suppressor mechanisms could no longer be demonstrated. These data are consistent with a clonal elimination hypothesis in that they do not provide evidence to indicate that maintenance of specific immune tolerance is mediated by an active suppressor mechanism.

  4. Suppression of inclusive J/$\\mathbf?$ and $\\mathbf?$(2S) production in p-Pb collisions with ALICE at the LHC

    E-Print Network [OSTI]

    Biswarup Paul; for the ALICE Collaboration

    2014-12-18T23:59:59.000Z

    The ALICE Collaboration has studied inclusive J/$\\psi$ and $\\psi$(2S) production in p-Pb collisions at $\\sqrt{s_{\\rm NN}} = 5.02$ TeV with the Muon Spectrometer. The measurement was performed at forward (2.03 $nuclear modification factor of J/$\\psi$ and $\\psi$(2S) has been measured as a function of transverse momentum and event activity. Theoretical models based on nuclear shadowing, coherent energy loss or both are in reasonable agreement with the J/$\\psi$ results but cannot describe the $\\psi$(2S) behaviour. Other mechanisms must be invoked in order to explain the $\\psi$(2S) suppression in p-Pb collisions.

  5. Suppression pattern of neutral pions at high transverse momentum in Au+Au collisions at sqrt(s_NN) = 200 GeV and constraints on medium transport coefficients

    E-Print Network [OSTI]

    PHENIX Collaboration; A. Adare

    2008-01-25T23:59:59.000Z

    For Au + Au collisions at 200 GeV we measure neutral pion production with good statistics for transverse momentum, p_T, up to 20 GeV/c. A fivefold suppression is found, which is essentially constant for 5 transport coefficient of the medium, e.g. \\mean(q^hat) in the parton quenching model. The spectral shape is similar for all collision classes, and the suppression does not saturate in Au+Au collisions; instead, it increases proportional to the number of participating nucleons, as N_part^2/3.

  6. Measurement of jet suppression in central Pb-Pb collisions at $\\sqrt{s_{\\rm NN}}$ = 2.76 TeV

    E-Print Network [OSTI]

    ALICE Collaboration

    2015-02-05T23:59:59.000Z

    The transverse momentum ($p_{\\rm T}$) spectrum and nuclear modification factor ($R_{\\rm AA}$) of reconstructed jets in 0-10% and 10-30% central Pb-Pb collisions at $\\sqrt{s_{\\rm NN}}=2.76$ TeV were measured. Jets were reconstructed from charged and neutral particles, utilizing the ALICE tracking detectors and Electromagnetic Calorimeter (EMCal), with the anti-$k_{\\rm T}$ jet algorithm with a resolution parameter of R=0.2. The jet $p_{\\rm T}$ spectra are reported in the pseudorapidity interval of $|{\\eta}_{\\rm jet}|5$ GeV/$c$ to suppress jets constructed from the combinatorial background in Pb-Pb collisions. The effect of the leading charged particle requirement has been studied in both pp and Pb-Pb collisions and has been shown to have negligible effects on the $R_{\\rm AA}$ within the uncertainties of the measurement. The nuclear modification factor is obtained by dividing the jet spectrum measured in Pb-Pb by that in pp collisions scaled by the number of independent nucleon-nucleon collisions estimated using a Glauber model. $R_{\\rm AA}$ is found to be $0.28\\pm0.04$ in 0-10% and $0.35\\pm0.04$ in 10-30% collisions, independent of $p_{\\rm T,jet}$ within the uncertainties of the measurement. The observed suppression is in fair agreement with expectations from two model calculations with different approaches to jet quenching.

  7. Ascofuranone suppresses EGF-induced HIF-1? protein synthesis by inhibition of the Akt/mTOR/p70S6K pathway in MDA-MB-231 breast cancer cells

    SciTech Connect (OSTI)

    Jeong, Yun-Jeong; Cho, Hyun-Ji [Research Institute of Biomedical Engineering and Department of Medicine, Catholic University of Daegu School of Medicine, Daegu 705-718 (Korea, Republic of); Magae, Junji [Magae Bioscience Institute, 49-4 Fujimidai, Tsukuba 300-1263 (Japan); Lee, In-Kyu [Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu 700-721 (Korea, Republic of); Park, Keun-Gyu, E-mail: kpark@knu.ac.kr [Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu 700-721 (Korea, Republic of); Chang, Young-Chae, E-mail: ycchang@cu.ac.kr [Research Institute of Biomedical Engineering and Department of Medicine, Catholic University of Daegu School of Medicine, Daegu 705-718 (Korea, Republic of)

    2013-12-15T23:59:59.000Z

    Hypoxia-inducible factor (HIF)-1 plays an important role in tumor progression, angiogenesis and metastasis. In this study, we investigated the potential molecular mechanisms underlying the anti-angiogenic effect of ascofuranone, an isoprenoid antibiotic from Ascochyta viciae, in epidermal growth factor (EGF)-1 responsive human breast cancer cells. Ascofuranone significantly and selectively suppressed EGF-induced HIF-1? protein accumulation, whereas it did not affect the expression of HIF-1?. Furthermore, ascofuranone inhibited the transcriptional activation of vascular endothelial growth factor (VEGF) by reducing protein HIF-1?. Mechanistically, we found that the inhibitory effects of ascofuranone on HIF-1? protein expression are associated with the inhibition of synthesis HIF-1? through an EGF-dependent mechanism. In addition, ascofuranone suppressed EGF-induced phosphorylation of Akt/mTOR/p70S6 kinase, but the phosphorylation of ERK/JNK/p38 kinase was not affected by ascofuranone. These results suggest that ascofuranone suppresses EGF-induced HIF-1? protein translation through the inhibition of Akt/mTOR/p70S6 kinase signaling pathways and plays a novel role in the anti-angiogenic action. - Highlights: • Inhibitory effect of ascofuranone on HIF-1? expression is EGF-specific regulation. • Ascofuranone decreases HIF-1? protein synthesis through Akt/mTOR pathways. • Ascofuranone suppresses EGF-induced VEGF production and tumor angiogenesis.

  8. VOLUME 81, NUMBER 23 P H Y S I C A L R E V I E W L E T T E R S 7 DECEMBER 1998 Dynamical Bloch Band Suppression in an Optical Lattice

    E-Print Network [OSTI]

    Texas at Austin. University of

    Suppression in an Optical Lattice K. W. Madison, M. C. Fischer, R. B. Diener, Qian Niu, and M. G. Raizen-cooled atoms in an optical lattice, rather than electrons in a superlattice. The main advantage of our system in the lowest band of a one-dimensional optical lattice. We then modulate the position of the potential

  9. A DC-81-indole conjugate agent suppresses melanoma A375 cell migration partially via interrupting VEGF production and stromal cell-derived factor-1{alpha}-mediated signaling

    SciTech Connect (OSTI)

    Hsieh, Ming-Chu [Graduate Institute of Pharmacy, Faculty of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan (China); Hu, Wan-Ping [Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan (China); Yu, Hsin-Su [Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan (China); Wu, Wen-Chuan [Department of Ophthalmology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan (China); Chang, Long-Sen [Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan (China); Kao, Ying-Hsien, E-mail: danyhkao@gmail.com [Department of Medical Research, E-DA Hospital, I-Shou University, Kaohsiung, Taiwan (China); Wang, Jeh-Jeng, E-mail: jjwang@kmu.edu.tw [Graduate Institute of Pharmacy, Faculty of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan (China); Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan (China)

    2011-09-01T23:59:59.000Z

    Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) chemicals are antitumor antibiotics inhibiting nucleic acid synthesis. An indole carboxylate-PBD hybrid with six-carbon spacer structure (IN6CPBD) has been previously demonstrated to induce melanoma cell apoptosis and reduce metastasis in mouse lungs. This study aimed at investigating the efficacy of the other hybrid compound with four-carbon spacer (IN4CPBD) and elucidating its anti-metastatic mechanism. Human melanoma A375 cells with IN4CPBD treatment underwent cytotoxicity and apoptosis-associated assays. Transwell migration assay, Western blotting, and ELISA were used for mechanistic study. IN4CPBD exhibited potent melanoma cytotoxicity through interrupting G1/S cell cycle progression, increasing DNA fragmentation and hypodipoidic DNA contents, and reducing mitochondrial membrane potential. Caspase activity elevation suggested that both intrinsic and extrinsic pathways were involved in IN4CPBD-induced melanoma apoptosis. IN4CPBD up-regulated p53 and p21, thereby concomitantly derailing the equilibrium between Bcl-2 and Bax levels. Transwell migration assay demonstrated that stromal cell-derived factor-1{alpha} (SDF-1{alpha}) stimulated A375 cell motility, while kinase inhibitors treatment confirmed that Rho/ROCK, Akt, ERK1/2, and p38 MAPK pathways were involved in SDF-1{alpha}-enhanced melanoma migration. IN4CPBD not only abolished the SDF-1{alpha}-enhanced chemotactic motility but also suppressed constitutive MMP-9 and VEGF expression. Mechanistically, IN4CPBD down-regulated Akt, ERK1/2, and p38 MAPK total proteins and MYPT1 phosphorylation. In conclusion, beyond the fact that IN4CPBD induces melanoma cell apoptosis at cytotoxic dose, the interruption in the VEGF expression and the SDF-1{alpha}-related signaling at cytostatic dose may partially constitute the rationale for its in vivo anti-metastatic potency. - Research Highlights: > A novel carboxylate-PBD hybrid as anti-melanoma drug. > IN4CPBD interrupts melanoma cell cycle progression and induces apoptosis. > IN4CPBD suppresses SDF-1{alpha}-enhanced signaling and melanoma migration. > IN4CPBD abolishes angiogenic factor production and chemotactic effect of SDF-1{alpha}. > This drug is clinically applicable to melanoma therapy.

  10. Suppression of activation energy and superconductivity by the addition of Al{sub 2}O{sub 3} nanoparticles in CuTl-1223 matrix

    SciTech Connect (OSTI)

    Jabbar, Abdul; Qasim, Irfan; Mumtaz, M.; Zubair, M.; Nadeem, K. [Materials Research Laboratory, Department of Physics, FBAS, International Islamic University (IIU) Islamabad, Islamabad 44000 (Pakistan); Khurram, A. A. [Experimental Physics Labs, National Centre for Physics, Islamabad (Pakistan)

    2014-05-28T23:59:59.000Z

    Low anisotropic (Cu{sub 0.5}Tl{sub 0.5})Ba{sub 2}Ca{sub 2}Cu{sub 3}O{sub 10??} (CuTl-1223) high T{sub c} superconducting matrix was synthesized by solid-state reaction and Al{sub 2}O{sub 3} nanoparticles were prepared separately by co-precipitation method. Al{sub 2}O{sub 3} nanoparticles were added with different concentrations during the final sintering cycle of CuTl-1223 superconducting matrix to get the required (Al{sub 2}O{sub 3}){sub y}/CuTl-1223, y?=?0.0, 0.5, 0.7, 1.0, and 1.5?wt.?%, composites. The samples were characterized by X-ray diffraction (XRD), scanning electron microscopy, energy dispersive X-ray, and dc-resistivity (?) measurements. The activation energy and superconductivity were suppressed with increasing concentration of Al{sub 2}O{sub 3} nanoparticles in (CuTl-1223) matrix. The XRD analysis showed that the addition of Al{sub 2}O{sub 3} nanoparticles did not affect the crystal structure of the parent CuTl-1223 superconducting phase. The suppression of activation energy and superconducting properties is most probably due to weak flux pinning in the samples. The possible reason of weak flux pinning is reduction of weak links and enhanced inter-grain coupling due to the presence of Al{sub 2}O{sub 3} nanoparticles at the grain boundaries. The presence of Al{sub 2}O{sub 3} nanoparticles at the grain boundaries possibly reduced the number of flux pinning centers, which were present in the form of weak links in the pure CuTl-1223 superconducting matrix. The increase in the values of inter-grain coupling (?) deduced from the fluctuation induced conductivity analysis with the increased concentration of Al{sub 2}O{sub 3} nanoparticles is a theoretical evidence of improved inter-grain coupling.

  11. Market Mechanisms for Financing Green Real Estate Investments

    E-Print Network [OSTI]

    Jaffee, Dwight M.; Wallace, Nancy E.

    2009-01-01T23:59:59.000Z

    software package, ARGUS, which is widely used to organize and display the information, thus “nets” out the energy risk

  12. Suppression of Akt1 phosphorylation by adenoviral transfer of the PTEN gene inhibits hypoxia-induced proliferation of rat pulmonary arterial smooth muscle cells

    SciTech Connect (OSTI)

    Luo, Chunxia [Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing 400038 (China)] [Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing 400038 (China); Yi, Bin, E-mail: yibin1974@163.com [Department of Anesthesia, Southwest Hospital, Third Military Medical University, Chongqing 400038 (China) [Department of Anesthesia, Southwest Hospital, Third Military Medical University, Chongqing 400038 (China); Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing 400037 (China); Bai, Li [Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing 400037 (China)] [Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing 400037 (China); Xia, Yongzhi [Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing 400038 (China)] [Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing 400038 (China); Wang, Guansong; Qian, Guisheng [Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing 400037 (China)] [Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing 400037 (China); Feng, Hua [Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing 400038 (China)] [Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing 400038 (China)

    2010-07-02T23:59:59.000Z

    Recent findings identify the role of proliferation of pulmonary artery smooth muscle cells (PASMCs) in pulmonary vascular remodeling. Phosphoinositide 3 kinase (PI3K) and serine/threonine kinase (Akt) proteins are expressed in vascular smooth muscle cells. In addition, phosphatase and tensin homolog deleted on chromosome 10 (PTEN) has been identified as a negative regulator of cytokine signaling that inhibits the PI3K-Akt pathway. However, little is known about the role of PTEN/Akt signaling in hypoxia-associated vascular remodeling. In this study, we found that hypoxia-induced the expression of Akt1 mRNA and phosphorylated protein by at least twofold in rat PASMCs. Phospho-PTEN significantly decreased in the nuclei of PASMCs after hypoxic stimulation. After forcing over-expression of PTEN by adenovirus-mediated PTEN (Ad-PTEN) transfection, the expression of phospho-Akt1 was significantly suppressed in PASMCs at all time-points measured. Additionally, we showed here that hypoxia increased proliferation of PASMCs by nearly twofold and over-expression of PTEN significantly inhibited hypoxia-induced PASMCs proliferation. These findings suggest that phospho-PTEN loss in the nuclei of PASMCs under hypoxic conditions may be the major cause of aberrant activation of Akt1 and may, therefore, play an important role in hypoxia-associated pulmonary arterial remodeling. Finally, the fact that transfection with Ad-PTEN inhibits the phosphorylation of Akt1 in PASMCs suggests a potential therapeutic effect on hypoxia-associated pulmonary arterial remodeling.

  13. Suppression of spurious mode oscillation in mega-watt 77-GHz gyrotron as a high quality probe beam source for the collective Thomson scattering in LHD

    SciTech Connect (OSTI)

    Ogasawara, S. [Department of Energy Engineering and Science, Nagoya University, Nagoya 464-8463 (Japan); Kubo, S. [Department of Energy Engineering and Science, Nagoya University, Nagoya 464-8463 (Japan); National Institute for Fusion Science, 322-6 Oroshi-cho, Toki-shi 509-5292 (Japan); Nishiura, M.; Tanaka, K.; Shimozuma, T.; Yoshimura, Y.; Igami, H.; Takahashi, H.; Ito, S.; Takita, Y.; Kobayashi, S.; Mizuno, Y.; Okada, K. [National Institute for Fusion Science, 322-6 Oroshi-cho, Toki-shi 509-5292 (Japan); Tatematsu, Y.; Saito, T. [Research Center for Development of Far-Infrared Region, University of Fukui, Fukui 910-8507 (Japan); Minami, R.; Kariya, T.; Imai, T. [Plasma Research Center, University of Tsukuba, Tsukuba 305-8577 (Japan)

    2012-10-15T23:59:59.000Z

    Collective Thomson scattering (CTS) diagnostic requires a strong probing beam to diagnose a bulk and fast ion distribution function in fusion plasmas. A mega-watt gyrotron for electron cyclotron resonance heating is used as a probing beam in the large helical device. Spurious mode oscillations are often observed during the turning on/off phase of the modulation. The frequency spectra of the 77-GHz gyrotron output power have been measured, and then one of the spurious modes, which interferes with the CTS receiver system, is identified as the TE{sub 17,6} mode at the frequency of 74.7 GHz. The mode competition calculation indicates that the increase of the magnetic field strength at the gyrotron resonator can avoid such a spurious mode and excite only the main TE{sub 18,6} mode. The spurious radiation at the 74.7 GHz is experimentally demonstrated to be suppressed in the stronger magnetic field than that optimized for the high-power operation.

  14. Atomic Beam Merging and Suppression of Alkali Contaminants in Multi Body High Power Targets: Design and Test of Target and Ion Source Prototypes at ISOLDE

    E-Print Network [OSTI]

    Bouquerel, Elian J A; Lettry, J; Stora, T

    2009-01-01T23:59:59.000Z

    The next generation of high power ISOL-facilities will deliver intense and pure radioactive ion beams. Two key issues of developments mandatory for the forthcoming generation of ISOL target-ion source units are assessed and demonstrated in this thesis. The design and production of target and ion-source prototypes is described and dedicated measurements at ISOLDE-CERN of their radioisotope yields are analyzed. The purity of short lived or rare radioisotopes suffer from isobaric contaminants, notably alkalis which are highly volatile and easily ionized elements. Therefore, relying on their chemical nature, temperature controlled transfer lines were equipped with a tube of quartz that aimed at trapping these unwanted elements before they reached the ion source. The successful application yields high alkali-suppression factors for several elements (ie: 80, 82mRb, 126, 142Cs, 8Li, 46K, 25Na, 114In, 77Ga, 95, 96Sr) for quartz temperatures between 300ºC and 1100ºC. The enthalpies of adsorption on quartz were measu...

  15. The Superfluid State of a Bose Liquid as a Superposition of a Suppressed Bose-Eistein Condensate and an Intensive Pair Coherent Condensate

    E-Print Network [OSTI]

    E. A. Pashitskii; S. V. Mashkevich; S. I. Vilchynskyy

    2002-08-19T23:59:59.000Z

    A self-consistent model of the superfluid (SF) state of a Bose liquid with strong interaction between bosons is considered, in which at T=0, along with a weak single-particle Bose-Einstein condensate (BEC), there exists an intensive pair coherent condensate (PCC) of bosons, analogous to the Cooper pair condensate of fermions. Such a PCC emerges due to an effective attraction between bosons in some regions of momentum space, which results from an oscillating sign-changing momentum dependence of the Fourier component V(p) of the interaction potential. The collective many-body effects of renormalization ("screening") of the initial interaction, which are described by the bosonic polarization operator \\Pi(p,\\omega), lead to a suppression of the repulsion [V(p)>0] and an enhancement of the effective attraction [V(p)energy parts is obtained with account for the terms of first order in the BEC density. In the framework of the ``soft spheres'' model with the single fitting parameter--the value of the repulsion potential at r=0, a theoretical quasiparticle spectrum E(p) is obtained, which is in good accordance with the experimental spectrum E_{exp}(p) of elementary excitations in superfluid $^4$He.

  16. Inhibition of PRL-3 gene expression in gastric cancer cell line SGC7901 via microRNA suppressed reduces peritoneal metastasis

    SciTech Connect (OSTI)

    Li Zhengrong [Department of Gastrointestinopancreatic Surgery, First Affiliated Hospital, Sun Yat-sen University, Gastric Center of Sun Yat-sen University, Guangzhou 510080 (China); Zhan Wenhua [Department of Gastrointestinopancreatic Surgery, First Affiliated Hospital, Sun Yat-sen University, Gastric Center of Sun Yat-sen University, Guangzhou 510080 (China)]. E-mail: wcywk@hotmail.com; Wang Zhao [Department of Gastrointestinopancreatic Surgery, First Affiliated Hospital, Sun Yat-sen University, Gastric Center of Sun Yat-sen University, Guangzhou 510080 (China); Zhu Baohe [Department of Gastrointestinopancreatic Surgery, First Affiliated Hospital, Sun Yat-sen University, Gastric Center of Sun Yat-sen University, Guangzhou 510080 (China); He Yulong [Department of Gastrointestinopancreatic Surgery, First Affiliated Hospital, Sun Yat-sen University, Gastric Center of Sun Yat-sen University, Guangzhou 510080 (China); Peng Junsheng [Department of Gastrointestinopancreatic Surgery, First Affiliated Hospital, Sun Yat-sen University, Gastric Center of Sun Yat-sen University, Guangzhou 510080 (China); Cai Shirong [Department of Gastrointestinopancreatic Surgery, First Affiliated Hospital, Sun Yat-sen University, Gastric Center of Sun Yat-sen University, Guangzhou 510080 (China); Ma Jinping [Department of Gastrointestinopancreatic Surgery, First Affiliated Hospital, Sun Yat-sen University, Gastric Center of Sun Yat-sen University, Guangzhou 510080 (China)

    2006-09-15T23:59:59.000Z

    High expression of PRL-3, a protein tyrosine phosphatase, is proved to be associated with lymph node metastasis in gastric carcinoma from previous studies. In this paper, we examined the relationship between PRL-3 expression and peritoneal metastasis in gastric carcinoma. We applied the artificial miRNA (pCMV-PRL3miRNA), which is based on the murine miR-155 sequence, to efficiently silence the target gene expression of PRL-3 in SGC7901 gastric cancer cells at both mRNA and protein levels. Then we observed that, in vitro, pCMV-PRL3miRNA significantly depressed the SGC7901 cell invasion and migration independent of cellular proliferation. In vivo, PRL-3 knockdown effectively suppressed the growth of peritoneal metastases and improved the prognosis in nude mice. Therefore, we concluded that artificial miRNA can depress the expression of PRL-3, and that PRL-3 might be a potential therapeutic target for gastric cancer peritoneal metastasis.

  17. Suppression of the spin pumping in Pd/Ni{sub 81}Fe{sub 19} bilayers with nano-oxide layer

    SciTech Connect (OSTI)

    Kim, Duck-Ho; Kim, Hong-Hyoun; You, Chun-Yeol [Department of Physics, Inha University, Namgu Incheon 402-751 (Korea, Republic of)

    2011-08-15T23:59:59.000Z

    We demonstrate that the spin pumping effect can be effectively suppressed with a nano-oxide layer. Spin pumping effect manifests itself by an enhancement of the Gilbert damping parameter in normal metal/ferromagnetic hetero-structures, while many spintronics devices prefer smaller damping parameter. Since the spin pumping effect is directly related with the spin dependent interface conductance, we can modify the spin pumping by altering the interface conductance with the nano-oxide layer. We prepared series of Pd/Ni{sub 81}Fe{sub 19} bilayers with different pausing time between Pd and Ni{sub 81}Fe{sub 19} depositions in order to control the interface conductance. The Gilbert damping parameters are determined from the line-width measurements in the ferromagnetic resonance spectra for each pausing time sample. They are 0.0490, 0.0296, 0.0278, and 0.0251 for 0, 6, 30, and 60 s pausing time, respectively. We find that the damping parameter of Pd/Ni{sub 81}Fe{sub 19} is almost recovered to one of the Cu/Ni{sub 81}Fe{sub 19} bilayer with 60 s pausing time, while the static magnetic properties are not noticeably changed.

  18. Propofol pretreatment attenuates LPS-induced granulocyte-macrophage colony-stimulating factor production in cultured hepatocytes by suppressing MAPK/ERK activity and NF-{kappa}B translocation

    SciTech Connect (OSTI)

    Jawan, Bruno [Department of Anesthesiology and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Kao, Y.-H. [Department of Anesthesiology and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Department of Biological Sciences, National Sun Yat-Sen University, 70 Lien-Hai Road, Kaohsiung 804, Taiwan (China); Goto, Shigeru [Department of Surgery and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Department of Surgery, Iwao Hospital, 3059-1 Kawakami, Yufuin, Oita 879-5102 (Japan); Pan, M.-C. [Department of Anesthesiology and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Lin, Y.-C.; Hsu, L.-W.; Nakano, Toshiaki; Lai, C.-Y.; Sun, C.-K.; Cheng, Y.-F. [Department of Surgery and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Tai, M.-H. [Department of Biological Sciences, National Sun Yat-Sen University, 70 Lien-Hai Road, Kaohsiung 804, Taiwan (China); Department of Medical Research and Education, Kaohsiung Veterans General Hospital, 386 Ta-Chung 1st Road, Kaohsiung 813, Taiwan (China)] (and others)

    2008-06-15T23:59:59.000Z

    Propofol (PPF), a widely used intravenous anesthetic for induction and maintenance of anesthesia during surgeries, was found to possess suppressive effect on host immunity. This study aimed at investigating whether PPF plays a modulatory role in the lipopolysaccharide (LPS)-induced inflammatory cytokine expression in a cell line of rat hepatocytes. Morphological observation and viability assay showed that PPF exhibits no cytotoxicity at concentrations up to 300 {mu}M after 48 h incubation. Pretreatment with 100 {mu}M PPF for 24 h prior to LPS stimulation was performed to investigate the modulatory effect on LPS-induced inflammatory gene production. The results of semi-quantitative RT-PCR demonstrated that PPF pretreatment significantly suppressed the LPS-induced toll-like receptor (TLR)-4, CD14, tumor necrosis factor (TNF)-{alpha}, and granulocyte-macrophage colony-stimulating factor (GM-CSF) gene expression. Western blotting analysis showed that PPF pretreatment potentiated the LPS-induced TLR-4 downregulation. Flow cytometrical analysis revealed that PPF pretreatment showed no modulatory effect on the LPS-upregulated CD14 expression on hepatocytes. In addition, PPF pretreatment attenuated the phosphorylation of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and I{kappa}B{alpha}, as well as the nuclear translocation of NF-{kappa}B primed by LPS. Moreover, addition of PD98059, a MAPK kinase inhibitor, significantly suppressed the LPS-induced NF-{kappa}B nuclear translocation and GM-CSF production, suggesting that the PPF-attenuated GM-CSF production in hepatocytes may be attributed to its suppressive effect on MAPK/ERK signaling pathway. In conclusion, PPF as an anesthetic may clinically benefit those patients who are vulnerable to sepsis by alleviating sepsis-related inflammatory response in livers.

  19. Combination External Beam Radiation and Brachytherapy Boost With Androgen Suppression for Treatment of Intermediate-Risk Prostate Cancer: An Initial Report of CALGB 99809

    SciTech Connect (OSTI)

    Hurwitz, Mark D. [Dana-Farber/Brigham and Women's Cancer Center, Boston, MA (United States)], E-mail: mhurwitz@lroc.harvard.edu; Halabi, Susan [Harvard Medical School, Boston, MA (United States); Ou, San-San [CALGB Statistical Center, Duke University Medical Center, Durham, NC (United States); McGinnis, Lamar S. [Southeast Cancer Control Consortium, Winston Salem, NC (United States); Keuttel, Michael R. [Roswell Park Cancer Institute, Buffalo, NY (United States); DiBiase, Steven J. [University of Maryland Medical Center, Baltimore, MD (United States); Small, Eric J. [University of California at San Francisco Comprehensive Cancer Center, San Francisco, CA (United States)

    2008-11-01T23:59:59.000Z

    Purpose: Transperineal prostate brachytherapy (TPPB) can be used with external beam radiation therapy (EBRT) to provide a high-dose conformal boost to the prostate. The results of a multicenter Phase II trial assessing safety of combination of EBRT and TPPB boost with androgen suppression (AST) in treatment of intermediate-risk prostate cancer are present here. Materials and Methods: Patients had intermediate-risk prostate cancer. Six months of AST was administered. EBRT to the prostate and seminal vesicles was administered to 45Gy followed by TPPB using either {sup 125}I or {sup 103}Pd to deliver an additional 100Gy or 90Gy. Toxicity was graded using the National Cancer Institute CTC version 2 and the Radiation Therapy Oncology Group late radiation morbidity scoring systems. Results: Sixty-three patients were enrolled. Median follow-up was 38 months. Side effects of AST including sexual dysfunction and vasomotor symptoms were commonly observed. Apart from erectile dysfunction, short-term Grade 2 and 3 toxicity was noted in 21% and 7%, primarily genitourinary related. Long-term Grade 2 and 3 toxicities were noted in 13% and 3%. Two patients had Grade 3 dysuria that resolved with longer follow-up. The most common Grade 2 long-term toxicity was urinary frequency (5%). No biochemical or clinical evidence of progression was noted for the entire cohort. Conclusions: In a cooperative group setting, combination EBRT and TPPB boost with 6 months of AST was generally well tolerated with expected genitourinary and gastrointestinal toxicities. Further follow-up will be required to fully assess long-term toxicity and cancer control.

  20. Study of the doubly and singly Cabibbo suppressed decays D+ --> K+ pi- pi+ and D(s)+ --> K+ pi- pi+ in the FOCUS experiment

    SciTech Connect (OSTI)

    Edera, Laura

    2005-01-01T23:59:59.000Z

    This thesis illustrates a complete study of the doubly and singly Cabibbo suppressed decays D{sup +} and D{sub s}{sup +} {yields} K{sup +} {pi}{sup -}{pi}{sup +}. Data for this analysis have been collected by the fixed-target high-energy photoproduction experiment FOCUS at Fermilab. The authors have selected the D{sup +} and D{sub s}{sup +} samples with cuts to obtain a sufficiently high statistics, a good signal to noise ratio and, at the same time, eliminate possible contaminations from the more copious and favored decays. The D{sup +} yield consists of 189 {+-} 24 events, with a signal to noise ratio {approx} 1; the D{sub s}{sup +} yield is 567 {+-} 31 and the signal to noise ratio is {approx} 2.5. The authors have measured {Lambda}(D{sup +} {yields} K{sup +}{pi}{sup -}{pi}{sup +})/{Lambda}(D{sup +} {yields} K{sup -}{pi}{sup +}{pi}{sup +}) = 0.0065 {+-} 0.0008 {+-} 0.004 and {Lambda}(D{sub s}{sup +} {yields} K{sup +}{pi}{sup -}{pi}{sup +})/{Lambda}(D{sub s}{sup +} {yields} K{sup +}K{sup -}{pi}{sup +}) = 0.127 {+-} 0.007 {+-} 0.014, improving the previous determinations of a factor of 2 and 5, respectively. The author has also performed a Dalitz plot analysis for both decays. The amplitude analysis for D{sub s}{sup +} {yields} K{sup +}{pi}{sup -}{pi}{sup +} represents the first available measurement for this channel.

  1. Fire suppressing apparatus. [sodium fires

    DOE Patents [OSTI]

    Buttrey, K.E.

    1980-12-19T23:59:59.000Z

    Apparatus for smothering a liquid sodium fire comprises a pan, a perforated cover on the pan, and tubed depending from the cover and providing communication between the interior of the pan and the ambient atmosphere through the perforations in the cover. Liquid caught in the pan rises above the lower ends of the tubes and thus serves as a barrier which limits the amount of air entering the pan.

  2. Quantitative Constraints on the Transport Properties of Hot Partonic Matter from Semi-Inclusive Single High Transverse Momentum Pion Suppression in Au+Au collisions at sqrt(s_NN) = 200 GeV

    E-Print Network [OSTI]

    PHENIX Collaboration; A. Adare

    2008-09-26T23:59:59.000Z

    The PHENIX experiment has measured the suppression of semi-inclusive single high transverse momentum pi^0's in Au+Au collisions at sqrt(s_NN) = 200 GeV. The present understanding of this suppression is in terms of energy-loss of the parent (fragmenting) parton in a dense color-charge medium. We have performed a quantitative comparison between various parton energy-loss models and our experimental data. The statistical point-to-point uncorrelated as well as correlated systematic uncertainties are taken into account in the comparison. We detail this methodology and the resulting constraint on the model parameters, such as the initial color-charge density dN^g/dy, the medium transport coefficient , or the initial energy-loss parameter epsilon_0. We find that high transverse momentum pi^0 suppression in Au+Au collisions has sufficient precision to constrain these model dependent parameters at the +/1 20%-25% (one standard deviation) level. These constraints include only the experimental uncertainties, and further studies are needed to compute the corresponding theoretical uncertainties.

  3. Measurements of branching fraction ratios and CP-asymmetries in suppressed B-? D(? K+?-)K- and B-? D(? K+?-)?- decays

    SciTech Connect (OSTI)

    Aaltonen, T. [Helsinki Inst. of Physics; Gonzalez, Alvarez B. [Oviedo U., Cantabria Inst. of Phys.; Amerio, S. [INFN, Padua; Amidei, D. [Michigan U.; Anastassov, A. [Northwestern U.; Annovi, A. [Frascati; Antos, J [Comenius U.; Apollinari, G. [Fermilab; Appel, J. A [Fermilab; Apresyan, A. [Purdue; Arisawa, T. [Waseda U., Dubna, JINR

    2011-08-01T23:59:59.000Z

    We report the first reconstruction in hadron collisions of the suppressed decays B-? D(? K+?-)K- and B-? D(? K+?-)?- decays, sensitive to the CKM phase {gamma}, using data from 7 fb-1 of integrated luminosity collected by the CDF II detector at the Tevatron collider. We reconstruct a signal for the B-? D(? K+?-)K- suppressed mode with a significance of 3.2 standard deviations, and measure the ratios of the suppressed to favored branching fractions R(K) = [22.0 ± 8.6(stat) ± 2.6(syst)] x 10-3, R+(K) = [42.6 ± 13.7(stat) ± 2.8(syst)] x 10-3, R-(K) = [3.8 ± 10.3(stat) ± 2.7(syst)] x 10-3 as well as the direct CP-violating asymmetry A(K) = -0.82±0.44(stat)±0.09(syst) of this mode. Corresponding quantities for B- ? D(? K+?-)?- decay are also reported.

  4. Suppression of the metal-insulator transition by magnetic field in (Pr{sub 1?y}Y{sub y}){sub 0.7}Ca{sub 0.3}CoO{sub 3} (y?=?0.0625)

    SciTech Connect (OSTI)

    Naito, Tomoyuki, E-mail: tnaito@iwate-u.ac.jp; Fujishiro, Hiroyuki [Faculty of Engineering, Iwate University, Morioka 020-8551 (Japan); Nishizaki, Terukazu; Kobayashi, Norio [Institute for Materials Research, Tohoku University, Sendai 980-8577 (Japan); Hejtmánek, Ji?í; Knížek, Karel; Jirák, Zden?k [Institute of Physics, ASCR, Cukrovarnická 10, 162 00 Prague 6 (Czech Republic)

    2014-06-21T23:59:59.000Z

    The (Pr{sub 1?y}Y{sub y}){sub 0.7}Ca{sub 0.3}CoO{sub 3} compound (y?=?0.0625, T{sub MI-SS}=40?K), at the lower limit for occurrence of the first-order metal-insulator (MI) and simultaneous spin-state (SS) transitions, has been studied using electrical resistivity and magnetization measurements in magnetic fields up to 17?T. The isothermal experiments demonstrate that the low-temperature insulating phase can be destabilized by an applied field and the metallic phase returns well below the transition temperature T{sub MI-SS}. The reverse process with decreasing field occurs with a significant hysteresis. The temperature scans taken at fixed magnetic fields reveal a parabolic-like decrease in T{sub MI-SS} with increasing field strength and a complete suppression of the MI-SS transition in fields above 9?T.

  5. Suppression of thermal carrier escape and efficient photo-carrier generation by two-step photon absorption in InAs quantum dot intermediate-band solar cells using a dot-in-well structure

    SciTech Connect (OSTI)

    Asahi, S.; Teranishi, H.; Kasamatsu, N.; Kada, T.; Kaizu, T.; Kita, T. [Department of Electrical and Electronic Engineering, Graduate School of Engineering, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501 (Japan)

    2014-08-14T23:59:59.000Z

    We investigated the effects of an increase in the barrier height on the enhancement of the efficiency of two-step photo-excitation in InAs quantum dot (QD) solar cells with a dot-in-well structure. Thermal carrier escape of electrons pumped in QD states was drastically reduced by sandwiching InAs/GaAs QDs with a high potential barrier of Al{sub 0.3}Ga{sub 0.7}As. The thermal activation energy increased with the introduction of the barrier. The high potential barrier caused suppression of thermal carrier escape and helped realize a high electron density in the QD states. We observed efficient two-step photon absorption as a result of the high occupancy of the QD states at room temperature.

  6. Ultraviolet GaN photodetectors on Si via oxide buffer heterostructures with integrated short period oxide-based distributed Bragg reflectors and leakage suppressing metal-oxide-semiconductor contacts

    SciTech Connect (OSTI)

    Szyszka, A., E-mail: szyszka@ihp-microelectronics.com, E-mail: adam.szyszka@pwr.wroc.pl [IHP, Im Technologiepark 25, 15236 Frankfurt (Oder) (Germany); Faculty of Microsystem Electronics and Photonics, Wroclaw University of Technology, Janiszewskiego 11/17, 50-372 Wroclaw (Poland); Lupina, L.; Lupina, G.; Schubert, M. A.; Zaumseil, P. [IHP, Im Technologiepark 25, 15236 Frankfurt (Oder) (Germany); Haeberlen, M.; Storck, P.; Thapa, S. B. [Siltronic, Hanns-Seidel-Platz 4, 81737 München (Germany); Schroeder, T. [IHP, Im Technologiepark 25, 15236 Frankfurt (Oder) (Germany); BTU Cottbus-Senftenberg, Konrad-Zuse-Strasse 1, 03046 Cottbus (Germany)

    2014-08-28T23:59:59.000Z

    Based on a novel double step oxide buffer heterostructure approach for GaN integration on Si, we present an optimized Metal-Semiconductor-Metal (MSM)-based Ultraviolet (UV) GaN photodetector system with integrated short-period (oxide/Si) Distributed Bragg Reflector (DBR) and leakage suppressing Metal-Oxide-Semiconductor (MOS) electrode contacts. In terms of structural properties, it is demonstrated by in-situ reflection high energy electron diffraction and transmission electron microscopy-energy dispersive x-ray studies that the DBR heterostructure layers grow with high thickness homogeneity and sharp interface structures sufficient for UV applications; only minor Si diffusion into the Y{sub 2}O{sub 3} films is detected under the applied thermal growth budget. As revealed by comparative high resolution x-ray diffraction studies on GaN/oxide buffer/Si systems with and without DBR systems, the final GaN layer structure quality is not significantly influenced by the growth of the integrated DBR heterostructure. In terms of optoelectronic properties, it is demonstrated that—with respect to the basic GaN/oxide/Si system without DBR—the insertion of (a) the DBR heterostructures and (b) dark current suppressing MOS contacts enhances the photoresponsivity below the GaN band-gap related UV cut-off energy by almost up to two orders of magnitude. Given the in-situ oxide passivation capability of grown GaN surfaces and the one order of magnitude lower number of superlattice layers in case of higher refractive index contrast (oxide/Si) systems with respect to classical III-N DBR superlattices, virtual GaN substrates on Si via functional oxide buffer systems are thus a promising robust approach for future GaN-based UV detector technologies.

  7. Branching fraction measurements of the color-suppressed decays B[over-bar] 0 to D[superscript (*)0?0, D[superscript (*)0]?, D[superscript (*)0]?, and D[superscript(*)0]?? and measurement of the polarization in the decay B[over-bar] 0-->D[superscript *0]?

    E-Print Network [OSTI]

    Cowan, Ray Franklin

    We report updated branching fraction measurements of the color-suppressed decays B? 0-->D0?0, D*0?0, D0?, D*0?, D0?, D*0?, D0??, and D*0??. We measure the branching fractions (×10-4): B(B? 0?D0?0)=2.69±0.09±0.13, B(B? ...

  8. Inhibition of fatty acid synthase suppresses U-2 OS cell invasion and migration via downregulating the activity of HER2/PI3K/AKT signaling pathway in vitro

    SciTech Connect (OSTI)

    Wang, Tao Fang; Wang, Heng [Department of Orthopedics, First Affiliated Hospital of Nanchang University, Jiangxi (China)] [Department of Orthopedics, First Affiliated Hospital of Nanchang University, Jiangxi (China); Peng, Ai Fen [Jiangxi University of Traditional Chinese Medicine, Jiangxi (China)] [Jiangxi University of Traditional Chinese Medicine, Jiangxi (China); Luo, Qing Feng [Department of Pathology, Cancer Hospital of Jiangxi Province, Jiangxi (China)] [Department of Pathology, Cancer Hospital of Jiangxi Province, Jiangxi (China); Liu, Zhi Li, E-mail: zgm7977@163.com [Department of Orthopedics, First Affiliated Hospital of Nanchang University, Jiangxi (China); Zhou, Rong Ping [Department of Orthopedics, Second Affiliated Hospital of Nanchang University, Jiangxi (China)] [Department of Orthopedics, Second Affiliated Hospital of Nanchang University, Jiangxi (China); Gao, Song; Zhou, Yang; Chen, Wen Zhao [Department of Orthopedics, First Affiliated Hospital of Nanchang University, Jiangxi (China)] [Department of Orthopedics, First Affiliated Hospital of Nanchang University, Jiangxi (China)

    2013-10-18T23:59:59.000Z

    Highlights: •We investigate the relationship between FASN and HER2 or p-HER2 by IHC in OS tissues. •We construct FASN-specific RNAi plasmid. •Inhibiting FASN down-regulates HER2/PI3K/AKT cell signaling in U-2 OS. •Inhibiting FASN blocks U-2 OS cell invasion and migration. -- Abstract: FASN plays an important role in the malignant phenotype of various tumors. Our previous studies show that inhibition FASN could induce apoptosis and inhibit proliferation in human osteosarcoma (OS) cell in vivo and vitro. The aim in this study was to investigate the effect of inhibition FASN on the activity of HER2/PI3K/AKT axis and invasion and migration of OS cell. The expression of FASN, HER2 and p-HER2(Y1248) proteins was detected by immunohistochemistry in OS tissues from 24 patients with pulmonary metastatic disease, and the relationship between FASN and p-HER2 as well as HER2 was investigated. The results showed that there was a positive correlation between FASN and HER2 as well as p-HER2 protein expression. The U-2 OS cells were transfected with either the FASN specific RNAi plasmid or the negative control RNAi plasmid. FASN mRNA was measured by RT-PCR. Western blot assays was performed to examine the protein expression of FASN, HER2, p-HER2(Y1248), PI3K, Akt and p-Akt (Ser473). Migration and invasion of cells were investigated by wound healing and transwell invasion assays. The results showed that the activity of HER2/PI3K/AKT signaling pathway was suppressed by inhibiting FASN. Meanwhile, the U-2OS cells migration and invasion were also impaired by inhibiting the activity of FASN/HER2/PI3K/AKT. Our results indicated that inhibition of FASN suppresses OS cell invasion and migration via down-regulation of the “HER2/PI3K/AKT” axis in vitro. FASN blocker may be a new therapeutic strategy in OS management.

  9. Argonne, Evigia finalize licensing agreement for next-gen RFID...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ARG-US software suite will be further developed and marketed by Evigia as a comprehensive nuclear and hazardous material handling solution. The system, jointly developed by Evigia...

  10. Radiofrequency Ablation of Liver Tumors in Combination with Local OK-432 Injection Prolongs Survival and Suppresses Distant Tumor Growth in the Rabbit Model with Intra- and Extrahepatic VX2 Tumors

    SciTech Connect (OSTI)

    Kageyama, Ken, E-mail: kageyamaken0112@gmail.com; Yamamoto, Akira, E-mail: loveakirayamamoto@gmail.com; Okuma, Tomohisa, E-mail: o-kuma@msic.med.osaka-cu.ac.jp; Hamamoto, Shinichi, E-mail: hamashin_tigers1975@yahoo.co.jp; Takeshita, Toru, E-mail: takeshita3595@view.ocn.ne.jp; Sakai, Yukimasa, E-mail: sakaiy@trust.ocn.ne.jp; Nishida, Norifumi, E-mail: norifumin@med.osaka-cu.ac.jp; Matsuoka, Toshiyuki, E-mail: tmatsuoka@msic.med.osaka-cu.ac.jp; Miki, Yukio, E-mail: yukio.miki@med.osaka-cu.ac.jp [Osaka City University, Department of Radiology, Graduate School of Medicine (Japan)] [Osaka City University, Department of Radiology, Graduate School of Medicine (Japan)

    2013-10-15T23:59:59.000Z

    Purpose: To evaluate survival and distant tumor growth after radiofrequency ablation (RFA) and local OK-432 injection at a single tumor site in a rabbit model with intra- and extrahepatic VX2 tumors and to examine the effect of this combination therapy, which we termed immuno-radiofrequency ablation (immunoRFA), on systemic antitumor immunity in a rechallenge test. Methods: Our institutional animal care committee approved all experiments. VX2 tumors were implanted to three sites: two in the liver and one in the left ear. Rabbits were randomized into four groups of seven to receive control, RFA alone, OK-432 alone, and immunoRFA treatments at a single liver tumor at 1 week after implantation. Untreated liver and ear tumor volumes were measured after the treatment. As the rechallenge test, tumors were reimplanted into the right ear of rabbits, which survived the 35 weeks and were followed up without additional treatment. Statistical significance was examined by log-rank test for survival and Student's t test for tumor volume. Results: Survival was significantly prolonged in the immunoRFA group compared to the other three groups (P < 0.05). Untreated liver and ear tumor sizes became significantly smaller after immunoRFA compared to controls (P < 0.05). In the rechallenge test, the reimplanted tumors regressed without further therapy compared to the ear tumors of the control group (P < 0.05). Conclusion: ImmunoRFA led to improved survival and suppression of distant untreated tumor growth. Decreases in size of the distant untreated tumors and reimplanted tumors suggested that systemic antitumor immunity was enhanced by immunoRFA.

  11. Interference suppression in spread-spectrum networks

    E-Print Network [OSTI]

    Sui, Haichang

    2007-01-01T23:59:59.000Z

    G. Proakis, “Analysis of a MISO pre- BLAST-DFE technique forpre-BLAST-DFE technique for MISO channels with decentralized

  12. Carbon fuel cells with carbon corrosion suppression

    DOE Patents [OSTI]

    Cooper, John F. (Oakland, CA)

    2012-04-10T23:59:59.000Z

    An electrochemical cell apparatus that can operate as either a fuel cell or a battery includes a cathode compartment, an anode compartment operatively connected to the cathode compartment, and a carbon fuel cell section connected to the anode compartment and the cathode compartment. An effusion plate is operatively positioned adjacent the anode compartment or the cathode compartment. The effusion plate allows passage of carbon dioxide. Carbon dioxide exhaust channels are operatively positioned in the electrochemical cell to direct the carbon dioxide from the electrochemical cell.

  13. Power Suppression in D-Brane Inflation

    E-Print Network [OSTI]

    Akers, Christopher Nelson

    2013-10-01T23:59:59.000Z

    where we think it is. We check this by plotting as a function of N, and making sure that it is satisfied while the inflaton is on the left side of the flat region. 26 FIG. 16. We see that around . Afterwards, slow-roll inflation...) (2013), arXiv:1303.5076 [astro-ph.CO]. [6] P. A. R. Ade et al. [BICEP2 Collaboration], arXiv:1403.3985 [astro-ph.CO]. [7] Baumann et al., arXiv:0706.0360 [hep-th]. [8] Trodden et al., arXiv:astro-ph/0401547. [9] S. Dodelson, Modern Cosmology...

  14. Suppression of automotive radio frequency interference 

    E-Print Network [OSTI]

    McLaughlin, Cleon Crosby

    1969-01-01T23:59:59.000Z

    of the spark plug and dlstribijtor gap brcakdo'sns is r epr educed by sc'ri tchi ng from an equiva- lent capacj cor befo'. gap Lreakdo'sn to an equivalent gap res j stance aiel:i ndu'':!nce dur. , nrJ b i akdo~sn This capa- bil i tV i ' . &ne &of the major... into lumped clem!'. nts and by providing equiva. 'ent cir uits for the disirib!!tor and spark plug gapa in both co! ducting and non ? conducti. ng states. Unfor unatcly, the state variable rr. odel recuires a grea. i deal of computer time in order...

  15. Suppression of automotive radio frequency interference

    E-Print Network [OSTI]

    McLaughlin, Cleon Crosby

    1969-01-01T23:59:59.000Z

    . e manu fac i ur ers began putt: i ng re. ! '= t o '. '' o!& " . '1 s . ance &v'xi &'- i nto Lhe 1g?1 tao & sys tc. ", &'' they found I&ha L- suf F i ?i = . . . i& sup&!ze =, sion was ob tai ned Lo mc?t i&i!e sp&!&! i f i ?etio?s = nd r equi...

  16. Raman laser with controllable suppression of parasitics

    DOE Patents [OSTI]

    George, E. Victor (Livermore, CA)

    1986-01-01T23:59:59.000Z

    Method and apparatus for switching energy out of a Raman laser optical cavity. Coherent radiation at both the pump and first Stokes wave frequencies are introduced into the optical cavity from the same direction, and a second Stokes wave is utilized to switch the energy out of the cavity.

  17. Superstitious suppression of a conditioned response

    E-Print Network [OSTI]

    Harding, Thomas Hague

    1971-01-01T23:59:59.000Z

    of three groups (3 Ss per group). Respcnses were main- tained by a VI-1 minute schedule of food reinforcement. A concurrent punishment schedule (VI-2 minute) was used in which group 1 received contingent shock and group 3 received noncontingent shock... throughout. Group 2 (the experimental group) received contingent shock initially and was then switched to noncontingent shock. It was hypothesized that the response rate of group 2 would approximate that of group l. However, after the punishment...

  18. Suppressing cascades of load in interdependent networks

    E-Print Network [OSTI]

    Wolpert, Robert L

    in coupled electric grids and other infrastructure, we study the Bak­ Tang­Wiesenfeld sandpile model network, for instance, turns turbines and cools nuclear reactors in the electrical grid, which powers within individual power grids using probabilistic models (15), linearized electric power dynamics

  19. Defect suppression from the compound semiconductor heterointerfaces

    SciTech Connect (OSTI)

    Kalem, S. [TUBITAK-Marmara Research Center, Gebze (Turkey); Curtis, A.; Hartmann, Q.J.; Thomas, S.; Turnbull, D.; Chuang, H.; Bishop, S.G.; Stillman, G.E. [Univ. of Illinois, Urbana, IL (United States). Center for Compound Semiconductor Microelectronics

    1996-12-31T23:59:59.000Z

    The authors report on the effect of inserting ultra-thin InAs layers at the heterointerfaces on physical properties of GaAs/InGaP on GaAs and InP/GaAs on InP grown by MOCVD and MOMBE, respectively. It is shown that the insertion of ultra thin InAs layers at the heterostructure interfaces has a significant effect in eliminating defects from the interfaces.

  20. Blast Effects Suppression System - Energy Innovation Portal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office511041clothAdvanced Materials Advanced Materials Find FindRewind Generator Rewind Denison PowerhouseBlast

  1. Dmitri Babikov (dmitri.babikov@mu.edu; 288-3538) Quantum Origin of Anomalous Isotope Effect in Ozone Formation

    E-Print Network [OSTI]

    Reid, Scott A.

    -Function Analyses of photocatalytic hybrid materials for solar energy conversion James Kincaid Effect in Ozone Formation · Mixed Quantum/Classical Theory for Collisional Energy Transfer: The Intriguing Story of the Iso-Halons Mark Steinmetz (mark

  2. Study of the near-threshold ? ? mass enhancement in doubly OZI-suppressed J / ? ? ? ? ? decays

    SciTech Connect (OSTI)

    Ablikim, M.; Achasov, M. N.; Albayrak, O.; Ambrose, D. J.; An, F. F.; An, Q.; Bai, J. Z.; Ban, Y.; Becker, J.; Bennett, J. V.; Bertani, M.; Bian, J. M.; Boger, E.; Bondarenko, O.; Boyko, I.; Briere, R. A.; Bytev, V.; Cai, X.; Cakir, O.; Calcaterra, A.; Cao, G. F.; Cetin, S. A.; Chang, J. F.; Chelkov, G.; Chen, G.; Chen, H. S.; Chen, J. C.; Chen, M. L.; Chen, S. J.; Chen, X.; Chen, Y. B.; Cheng, H. P.; Chu, Y. P.; Cronin-Hennessy, D.; Dai, H. L.; Dai, J. P.; Dedovich, D.; Deng, Z. Y.; Denig, A.; Denysenko, I.; Destefanis, M.; Ding, W. M.; Ding, Y.; Dong, L. Y.; Dong, M. Y.; Du, S. X.; Fang, J.; Fang, S. S.; Fava, L.; Feng, C. Q.; Ferroli, R. B.; Friedel, P.; Fu, C. D.; Gao, Y.; Geng, C.; Goetzen, K.; Gong, W. X.; Gradl, W.; Greco, M.; Gu, M. H.; Gu, Y. T.; Guan, Y. H.; Guo, A. Q.; Guo, L. B.; Guo, T.; Guo, Y. P.; Han, Y. L.; Harris, F. A.; He, K. L.; He, M.; He, Z. Y.; Held, T.; Heng, Y. K.; Hou, Z. L.; Hu, C.; Hu, H. M.; Hu, J. F.; Hu, T.; Huang, G. M.; Huang, G. S.; Huang, J. S.; Huang, L.; Huang, X. T.; Huang, Y.; Huang, Y. P.; Hussain, T.; Ji, C. S.; Ji, Q.; Ji, Q. P.; Ji, X. B.; Ji, X. L.; Jiang, L. L.; Jiang, X. S.; Jiao, J. B.; Jiao, Z.; Jin, D. P.; Jin, S.; Jing, F. F.; Kalantar-Nayestanaki, N.; Kavatsyuk, M.; Kopf, B.; Kornicer, M.; Kuehn, W.; Lai, W.; Lange, J. S.; Leyhe, M.; Li, C. H.; Li, Cheng; Li, Cui; Li, D. M.; Li, F.; Li, G.; Li, H. B.; Li, J. C.; Li, K.; Li, Lei; Li, Q. J.; Li, S. L.; Li, W. D.; Li, W. G.; Li, X. L.; Li, X. N.; Li, X. Q.; Li, X. R.; Li, Z. B.; Liang, H.; Liang, Y. F.; Liang, Y. T.; Liao, G. R.; Liao, X. T.; Lin, D.; Liu, B. J.; Liu, C. L.; Liu, C. X.; Liu, F. H.; Liu, Fang; Liu, Feng; Liu, H.; Liu, H. B.; Liu, H. H.; Liu, H. M.; Liu, H. W.; Liu, J. P.; Liu, K.; Liu, K. Y.; Liu, Kai; Liu, P. L.; Liu, Q.; Liu, S. B.; Liu, X.; Liu, Y. B.; Liu, Z. A.; Liu, Zhiqiang; Liu, Zhiqing; Loehner, H.; Lu, G. R.; Lu, H. J.; Lu, J. G.; Lu, Q. W.; Lu, X. R.; Lu, Y. P.; Luo, C. L.; Luo, M. X.; Luo, T.; Luo, X. L.; Lv, M.; Ma, C. L.; Ma, F. C.; Ma, H. L.; Ma, Q. M.; Ma, S.; Ma, T.; Ma, X. Y.; Maas, F. E.; Maggiora, M.; Malik, Q. A.; Mao, Y. J.; Mao, Z. P.; Messchendorp, J. G.; Min, J.; Min, T. J.; Mitchell, R. E.; Mo, X. H.; Morales Morales, C.; Muchnoi, N. Yu.; Muramatsu, H.; Nefedov, Y.; Nicholson, C.; Nikolaev, I. B.; Ning, Z.; Olsen, S. L.; Ouyang, Q.; Pacetti, S.; Park, J. W.; Pelizaeus, M.; Peng, H. P.; Peters, K.; Ping, J. L.; Ping, R. G.; Poling, R.; Prencipe, E.; Qi, M.; Qian, S.; Qiao, C. F.; Qin, L. Q.; Qin, X. S.; Qin, Y.; Qin, Z. H.; Qiu, J. F.; Rashid, K. H.; Rong, G.; Ruan, X. D.; Sarantsev, A.; Schaefer, B. D.; Shao, M.; Shen, C. P.; Shen, X. Y.; Sheng, H. Y.; Shepherd, M. R.; Song, X. Y.; Spataro, S.; Spruck, B.; Sun, D. H.; Sun, G. X.; Sun, J. F.; Sun, S. S.; Sun, Y. J.; Sun, Y. Z.; Sun, Z. J.; Sun, Z. T.; Tang, C. J.; Tang, X.; Tapan, I.; Thorndike, E. H.; Toth, D.; Ullrich, M.; Varner, G. S.; Wang, B. Q.; Wang, D.; Wang, D. Y.; Wang, K.; Wang, L. L.; Wang, L. S.; Wang, M.; Wang, P.; Wang, P. L.; Wang, Q. J.; Wang, S. G.; Wang, X. F.; Wang, X. L.; Wang, Y. F.; Wang, Z.; Wang, Z. G.; Wang, Z. Y.; Wei, D. H.; Wei, J. B.; Weidenkaff, P.; Wen, Q. G.; Wen, S. P.; Werner, M.; Wiedner, U.; Wu, L. H.; Wu, N.; Wu, S. X.; Wu, W.; Wu, Z.; Xia, L. G.; Xiao, Z. J.; Xie, Y. G.; Xiu, Q. L.; Xu, G. F.; Xu, G. M.; Xu, Q. J.; Xu, Q. N.; Xu, X. P.; Xu, Z. R.; Xue, F.; Xue, Z.; Yan, L.; Yan, W. B.; Yan, Y. H.; Yang, H. X.; Yang, Y.; Yang, Y. X.; Ye, H.; Ye, M.; Ye, M. H.; Yu, B. X.; Yu, C. X.; Yu, H. W.; Yu, J. S.; Yu, S. P.; Yuan, C. Z.; Yuan, Y.; Zafar, A. A.; Zallo, A.; Zeng, Y.; Zhang, B. X.; Zhang, B. Y.; Zhang, C.; Zhang, C. C.; Zhang, D. H.; Zhang, H. H.; Zhang, H. Y.; Zhang, J. Q.; Zhang, J. W.; Zhang, J. Y.; Zhang, J. Z.; Zhang, R.; Zhang, S. H.; Zhang, X. J.; Zhang, X. Y.; Zhang, Y.; Zhang, Y. H.; Zhang, Z. P.; Zhang, Z. Y.; Zhang, Zhenghao; Zhao, G.; Zhao, H. S.; Zhao, J. W.; Zhao, K. X.; Zhao, Lei; Zhao, Ling; Zhao, M. G.; Zhao, Q.; Zhao, Q. Z.; Zhao, S. J.; Zhao, T. C.; Zhao, Y. B.; Zhao, Z. G.; Zhemchugov, A.; Zheng, B.; Zheng, J. P.; Zheng, Y. H.; Zhong, B.; Zhong, Z.; Zhou, L.; Zhou, X. K.; Zhou, X. R.; Zhu, C.; Zhu, K.; Zhu, K. J.; Zhu, S. H.; Zhu, X. L.; Zhu, Y. C.; Zhu, Y. M.; Zhu, Y. S.; Zhu, Z. A.; Zhuang, J.; Zou, B. S.; Zou, J. H.

    2013-02-01T23:59:59.000Z

    A 2.25×10? J/? event sample accumulated with the BESIII detector is used to study the doubly Okubo-Zweig-Iizuka-suppressed decay modes J/?????, ????????, ??K?K?. A strong deviation (>30?) from three-body J/????? phase space is observed near the ?? mass threshold that is consistent with a previous observation reported by the BESII experiment. A partial wave analysis with a tensor covariant amplitude that assumes that the enhancement is due to the presence of a resonance, the X(1810), is performed and confirms that the spin-parity of the X(1810) is 0??. The mass and width of the X(1810) are determined to be M=1795±7(stat)+13-5(syst)±19(mod) MeV/c² and ?=95±10(stat)+21-34(syst)±75(mod) MeV/c², respectively, and the product branching fraction is measured to be B(J/???X(1810))×B(X(1810)???)=(2.00±0.08(stat)+0.45-1.00(syst)±1.30(mod))×10??. These results are consistent within errors with those of the BESII experiment.

  3. INMM 54th Annual Meeting, July 14-18, 2013, JW Marriott Desert Springs, Palm Desert, California USA Comprehensive Nuclear Material Surveillance with a

    E-Print Network [OSTI]

    Kemner, Ken

    ) technology, resulting in significant improvement of the operating efficiency of nuclear and radiological facilities. A system, called ARG-US, has been developed by Argonne National Laboratory for the U

  4. Outlook for U.S. shale oil and gas

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Argus Americas Crude Summit January 22, 2014 | Houston, TX By Adam Sieminski, EIA Administrator Six key plays account for nearly all recent growth in oil and natural gas production...

  5. To: The Wesleyan Community From: Nicole Updegrove `14

    E-Print Network [OSTI]

    Royer, Dana

    . Administrative responses, when present, are scattered across Argus and Wesleying articles, official blogs discussions of a new academic calendar during the 2012-2013 academic year. - Continue efforts to increase Academic - Low-inc

  6. Performance analysis of interference suppression techniques for multiple antenna systems

    E-Print Network [OSTI]

    Amihood, Patrick

    2007-01-01T23:59:59.000Z

    Pre-BLAST-DFE Technique for MISO Channels with DecentralizedPrecoding Operating over MISO Frequency Selec- tive Fadingon a Nonlinear Precoder for MISO Channels with Decentralized

  7. Swirl-counter-swirl microjets for thermoacoustic instability suppression

    DOE Patents [OSTI]

    Ghoniem, Ahmed F; LaBry, Zachary A; Shanbhogue, Santosh J; Speth, Raymond L

    2014-04-29T23:59:59.000Z

    Combustor. The combustor includes an axially symmetric tube along with means for introducing fuel and air into the tube. A swirler is disposed within the tube to impart rotation in a first direction to the air/fuel mixture. A plurality of holes downstream of the swirler are disposed around the tube and offset at an angle relative to an inward normal to the tube wall. Air is injected through the offset holes to impart rotation to the air/fuel mixture in a second direction opposite to the first direction. A combustion chamber having a diameter larger than that of the tube receives and burns the air/fuel mixture from the tube.

  8. J/Psi suppression in ultrarelativistic nuclear collisions 

    E-Print Network [OSTI]

    Zhang, B.; Ko, Che Ming; Li, Ba; Lin, ZW; Sa, BW.

    2000-01-01T23:59:59.000Z

    - though all these signals have been observed in heavy ion collisions at CERN SPS, alternative explanations without in- voking the formation of the quark-gluon plasma have also been proposed. As the QGP is expected to be produced at RHIC... experiments at the Relativistic Heavy Ion Collider ~RHIC!, which allows collisions at much high energies than those available previously, are expected to provide a better oppor- tunity to create the quark-gluon plasma and to study its prop- erties. Since...

  9. ORTHOGONALLY ANCHORED BLIND INTERFERENCE SUPPRESSION USING THE SATO COST CRITERION

    E-Print Network [OSTI]

    Honig, Michael L.

    by a stochastic gradient algorithm based on this approach is significantly greater than that pro- duced by the LMS. The orthogonally anchored Sato cost function leads to a stochastic gradient algorithm that performs significantly of received sam- ples corresponding to the ith transmitted bit at

  10. Oil palm phenolics suppresses oxidative stress and inflammation

    E-Print Network [OSTI]

    Sundaresan, Abaya Meenakshi

    2013-01-01T23:59:59.000Z

    Water-soluble Oil Palm Phenolics (OPP), derived from Elaeis guineensis, contains a unique blend of plant phenolics. Recent cell and animal studies have demonstrated positive health benefits in a number of different organ ...

  11. Bacterial Lipopolysaccharides Induce Suppression of Natural Killer Cell Function

    E-Print Network [OSTI]

    Orona, Gabriella Marie

    2012-01-01T23:59:59.000Z

    and J. Trowsdale, You say ITAM and I say ITIM, let's callbased activation motifs (ITAM’s) or immunoreceptor tyrosine-

  12. Forest Fire Spread and Suppression in DEVS Lewis Ntaimo1

    E-Print Network [OSTI]

    , in which all cells perform computations at every time step, the cellular DEVS approach allows computations event-based modeling approach enables efficient simulation of cell space and allows us to obtain timely ecology, wildfire risk, the dynamics of vegetation fuel, and how to reduce the likelihood of catastrophic

  13. Traveling-wave device with mass flux suppression

    DOE Patents [OSTI]

    Swift, Gregory W. (Santa Fe, NM); Backhaus, Scott N. (Los Alamos, NM); Gardner, David L. (White Rock, NM)

    2000-01-01T23:59:59.000Z

    A traveling-wave device is provided with the conventional moving pistons eliminated. Acoustic energy circulates in a direction through a fluid within a torus. A side branch may be connected to the torus for transferring acoustic energy into or out of the torus. A regenerator is located in the torus with a first heat exchanger located on a first side of the regenerator downstream of the regenerator relative to the direction of the circulating acoustic energy; and a second heat exchanger located on an upstream side of the regenerator. The improvement is a mass flux suppressor located in the torus to minimize time-averaged mass flux of the fluid. In one embodiment, the device further includes a thermal buffer column in the torus to thermally isolate the heat exchanger that is at the operating temperature of the device.

  14. Suppression and Enhancement of Boiling Associated with Multiple Droplet Impingement

    E-Print Network [OSTI]

    Yang, Yuxuan

    2014-05-01T23:59:59.000Z

    are at play simultaneously. Furthermore, experiments with single streams of droplets have not been able to elucidate the effects of the onset of boiling (ONB) during the droplet impingement process. Therefore, efforts have been undertaken to consider...

  15. Mechanisms underlying cross-orientation suppression in cat visual cortex

    E-Print Network [OSTI]

    Ferster, David

    for by the behavior of geniculate relay cells: contrast saturation and rectification in relay cell responses, when of presynaptic geniculate relay cells. Where the feed-forward model has traditionally failed, however the response to simulta- neously presented stimuli at the preferred orientation (test stimuli)3

  16. The Suppression of Energy Discretization Errors in Multigroup Transport Calculations

    SciTech Connect (OSTI)

    Larsen, Edward

    2013-06-17T23:59:59.000Z

    The Objective of this project is to develop, implement, and test new deterministric methods to solve, as efficiently as possible, multigroup neutron transport problems having an extremely large number of groups. Our approach was to (i) use the standard CMFD method to "coarsen" the space-angle grid, yielding a multigroup diffusion equation, and (ii) use a new multigrid-in-space-and-energy technique to efficiently solve the multigroup diffusion problem. The overall strategy of (i) how to coarsen the spatial and energy grids, and (ii) how to navigate through the various grids, has the goal of minimizing the overall computational effort. This approach yields not only the fine-grid solution, but also coarse-group flux-weighted cross sections that can be used for other related problems.

  17. acoustic howling suppression: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    by the Leningrad unknown authors 15 UNIVERSITY OF CALIFORNIA, SAN DIEGO Acoustic Daylight: passive acoustic imaging Geosciences Websites Summary: UNIVERSITY OF CALIFORNIA, SAN...

  18. Suppression of decoherence in a graphene monolayer ring

    SciTech Connect (OSTI)

    Smirnov, D., E-mail: smirnov@nano.uni-hannover.de; Rode, J. C.; Haug, R. J. [Institut für Festkörperphysik, Leibniz Universität Hannover, Appelstr. 2, 30167 Hannover (Germany)

    2014-08-25T23:59:59.000Z

    The influence of high magnetic fields on coherent transport is investigated. A monolayer graphene quantum ring is fabricated and the Aharonov-Bohm effect is observed. For increased magnitude of the magnetic field, higher harmonics appear. This phenomenon is attributed to an increase of the phase coherence length due to reduction of spin flip scattering.

  19. IJS DP 7954 RICH in the ECAL background suppression

    E-Print Network [OSTI]

    ­alone mode. For completeness we quote here their results. cut eff. s/b (s=b) (s=b) K TRIG =450 K TRIG = 450 0.56 2.9 1. K TRIG = 1000 0.39 6.5 2.2 K TRIG = 450 + e=ß 0.49 4.6 1.6 K TRIG = 1000 + e=ß 0.34 9.3 3.1 K TRIG = 450 + SVD 0.27 12 4.1 K TRIG = 1000 + SVD 0.20 20 6.9 K TRIG = 450 + SVD + e=ß 0.21 23 7. K TRIG

  20. Suppressed fusion cross section for neutron halo nuclei

    E-Print Network [OSTI]

    Makoto Ito; Kazuhiro Yabana; Takashi Nakatsukasa; Manabu Ueda

    2006-01-20T23:59:59.000Z

    Fusion reactions of neutron-halo nuclei are investigated theoretically with a three-body model. The time-dependent wave-packet method is used to solve the three-body Schrodinger equation. The halo neutron behaves as a spectator during the Coulomb dissociation process of the projectile. The fusion cross sections of 11Be-209Bi and 6He-238U are calculated and are compared with measurements. Our calculation indicates that the fusion cross section is slightly hindered by the presence of weakly bound neutrons.

  1. Suppressions and cascades : insights from gauge/gravity dualities

    E-Print Network [OSTI]

    Ejaz, Qudsia Jabeen

    2008-01-01T23:59:59.000Z

    At present, there are no non-perturbative analytic methods available for investigating gauge theories at large couplings. Consequently, it is desirable to explore more avenues to gain qualitative and quantitative insights. ...

  2. Multi-band OFDM UWB receiver with narrowband interference suppression

    E-Print Network [OSTI]

    Kelleci, Burak

    2009-05-15T23:59:59.000Z

    9768 MHz 10032 MHz 14 10032 MHz 10296 MHz 10560 MHz Binary Source Convolutional Encoder Puncture Symbol Interleaver Tone Interleaver QPSK Spreading Add Pilot and Zero DC Add FD Preamble IFFT Add TD Preamble Add Zero padding Add Guard... as 128. For 53.3 and 80 Mb/s data rates, the complex conjugate of the tones 1 to 61 are copied to 67 to 127, as illustrated in Fig. 6. The guard tones 62 to 66 and the 0 (DC) are set to zero. After performing the IFFT, a zero-padded suffix of length 37...

  3. PPPL extends system for suppressing instabilities to long-pulse...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    instabilities will be vital for future fusion facilities such as ITER, the huge international project under construction in France. The original system developed on...

  4. ORIGINAL ARTICLE Suppression of CFTR premature termination codons

    E-Print Network [OSTI]

    Bedwell, David M.

    DNA, treatment with NB54 increased stimulated short-circuit current (ISC) with greater efficiency than gentamicin termination codons . Aminoglycosides . Short-circuit current . Primary human bronchial epithelial cells conductance regulator ISC Short-circuit current PTC Premature termination codons SPQ 6-Methoxy-N-(3

  5. Higgs inflation and suppression of axion isocurvature perturbation

    E-Print Network [OSTI]

    Nakayama, Kazunori

    2015-01-01T23:59:59.000Z

    We point out that cosmological constraint from the axion isocurvature perturbation is relaxed if the Higgs field obtains a large field value during inflation in the DFSZ axion model. This scenario is consistent with the Higgs inflation model, in which two Higgs doublets have non-minimal couplings and play a role of inflaton.

  6. Higgs inflation and suppression of axion isocurvature perturbation

    E-Print Network [OSTI]

    Kazunori Nakayama; Masahiro Takimoto

    2015-05-22T23:59:59.000Z

    We point out that cosmological constraint from the axion isocurvature perturbation is relaxed if the Higgs field obtains a large field value during inflation in the DFSZ axion model. This scenario is consistent with the Higgs inflation model, in which two Higgs doublets have non-minimal couplings and play a role of inflaton.

  7. Optimal measurement strategies for effective suppression of drift errors

    E-Print Network [OSTI]

    Yashchuk, Valeriy V.

    2009-01-01T23:59:59.000Z

    Device for X-ray Optics at BESSY,” Proc. of AIP 705, 847–slope trace obtained with BESSY NOM (courtesy of Frankmeasuring instrument, the BESSY NOM, 16 proves the accuracy

  8. J/Psi suppression in ultrarelativistic nuclear collisions

    E-Print Network [OSTI]

    Zhang, B.; Ko, Che Ming; Li, Ba; Lin, ZW; Sa, BW.

    2000-01-01T23:59:59.000Z

    circles for Au1Au col- lisions and open circles for S1S collisions. The solid lines are polynomial fits to the above results using the form rc(t)5a01a1t1a2t21a3t3 for tmin,t,tmax , with rc(t) 5rc(tmin) for t,tmin and rc(t)50 for t.tmax . For the par...

  9. Observation of suppressed terahertz absorption in photoexcited graphene

    E-Print Network [OSTI]

    Frenzel, Alex James

    When light is absorbed by a semiconductor, photoexcited charge carriers enhance the absorption of far-infrared radiation due to intraband transitions. We observe the opposite behavior in monolayer graphene, a zero-gap ...

  10. Optimized pulse sequences for suppressing unwanted transitions in quantum systems

    SciTech Connect (OSTI)

    Schroeder, C. A.; Agarwal, G. S. [Homer L. Dodge Department of Physics and Astronomy, University of Oklahoma, 440 W. Brooks St. Norman, Oklahoma 73019 (United States); Department of Physics, Oklahoma State University, Stillwater, Oklahoma 74078 (United States)

    2011-01-15T23:59:59.000Z

    We investigate the nature of the pulse sequence so that unwanted transitions in quantum systems can be inhibited optimally. For this purpose we show that the sequence of pulses proposed by Uhrig [Phys. Rev. Lett. 98, 100504 (2007)] in the context of inhibition of environmental dephasing effects is optimal. We derive exact results for inhibiting the transitions and confirm the results numerically. We posit a very significant improvement by usage of the Uhrig sequence over an equidistant sequence in decoupling a quantum system from unwanted transitions. The physics of inhibition is the destructive interference between transition amplitudes before and after each pulse.

  11. Indirect suppression of photosynthesis on individual leaves by arthropod herbivory

    E-Print Network [OSTI]

    DeLucia, Evan H.

    . Key words: Chlorophyll fluorescence imaging, thermography, plant­insect interactions, spatial patterns

  12. Indirect Suppression of Photosynthesis on Individual Leaves by Arthropod Herbivory

    E-Print Network [OSTI]

    DeLucia, Evan H.

    of their physiological and ecological impacts. Key words: Chlorophyll fluorescence imaging, thermography, plant

  13. Suppression of microbunching instability using bending magnets in FEL linacs

    E-Print Network [OSTI]

    Qiang, Ji

    2014-01-01T23:59:59.000Z

    using bending magnets in FEL linacs Ji Qiang, Chad E.for free electron laser (FEL) radiation. In this letter, weaccelerators for next generation FEL light sources. Instead

  14. Novel rf mems tunable filters with adjustable spurious suppression 

    E-Print Network [OSTI]

    Sekar, Vikram

    2009-05-15T23:59:59.000Z

    This thesis presents the theory and design of fixed and Radio Frequency (RF) Microelectromechanical Systems (MEMS) -based tunable microwave filters for RF and microwave applications. The methodology for the design of coupled resonator filters...

  15. Immunotherapy of metastatic melanoma by reversal of immune suppression

    SciTech Connect (OSTI)

    Biggs, M.W.; Eiselein, J.E.

    1997-01-01T23:59:59.000Z

    Beginning with the observation that the human enteorvirus, Poliovirus Sabin 1, will lyse human melanoma cells in culture, clinical trials involving two patients with advance melanoma were performed. Parenteral injection of the viable Poliovirus into cutaneous melanoma metastases followed in 24 hours by oral administration of cyclophosphamide. The results of these two trials are described.

  16. Suppression of premixed combustion dynamics utilizing microjet air injection

    E-Print Network [OSTI]

    Hudgins, Duane Edward

    2008-01-01T23:59:59.000Z

    The problem of thermoacoustic instability in continuous combustion systems is a major challenge in the field of propulsion and power generation. With the current environmental and political pressure that is being placed ...

  17. Vibration suppression, stabilization, motion planning and tracking for flexible beams

    E-Print Network [OSTI]

    Siranosian, Antranik Antonio

    2009-01-01T23:59:59.000Z

    on the frequency of the disturbance. The perturbationvibrations at the frequency of the disturbance. Extremumexists a disturbance of varying frequency, then it would be

  18. Novel rf mems tunable filters with adjustable spurious suppression

    E-Print Network [OSTI]

    Sekar, Vikram

    2009-05-15T23:59:59.000Z

    This thesis presents the theory and design of fixed and Radio Frequency (RF) Microelectromechanical Systems (MEMS) -based tunable microwave filters for RF and microwave applications. The methodology for the design of coupled resonator filters...

  19. Alternative approach to fire suppression - Class A, B & C fire...

    Broader source: Energy.gov (indexed) [DOE]

    or battery systems required - Rugged construction and maintenance free - Vibration and Corrosion resistant U N C L A S S I F I E D U N C L A S S I F I E D Operated by the Los...

  20. RESEARCH ARTICLES A Conserved Mechanism of Bract Suppression in the

    E-Print Network [OSTI]

    Jackson, David

    ORGANS (UFO) (Hepworth et al., 2006). In addition, several genes with a general role in promoting leaf

  1. False arrhythmia alarm suppression using ECG, ABP, and photoplethysmogram

    E-Print Network [OSTI]

    Deshmane, Anagha Vishwas

    2009-01-01T23:59:59.000Z

    A signal quality assessment scheme for the photoplethysmogram waveform recorded by a pulse oximeter has been created. The signal quality algorithm uses statistical methods on time-series and spectral analysis to locate ...

  2. Mechanisms of Low Dose Radio-Suppression of Genomic Instability

    SciTech Connect (OSTI)

    Engelward, Bevin P

    2009-09-16T23:59:59.000Z

    The major goal of this project is to contribute toward the elucidation of the impact of long term low dose radiation on genomic stability. We have created and characterized novel technologies for delivering long term low dose radiation to animals, and we have studied genomic stability by applying cutting edge molecular analysis technologies. Remarkably, we have found that a dose rate that is 300X higher than background radiation does not lead to any detectable genomic damage, nor is there any significant change in gene expression for genes pertinent to the DNA damage response. These results point to the critical importance of dose rate, rather than just total dose, when evaluating public health risks and when creating regulatory guidelines. In addition to these studies, we have also further developed a mouse model for quantifying cells that have undergone a large scale DNA sequence rearrangement via homologous recombination, and we have applied these mice in studies of both low dose radiation and space radiation. In addition to more traditional approaches for assessing genomic stability, we have also explored radiation and possible beneficial effects (adaptive response), long term effects (persistent effects) and effects on communication among cells (bystander effects), both in vitro and in vivo. In terms of the adaptive response, we have not observed any significant induction of an adaptive response following long term low dose radiation in vivo, delivered at 300X background. In terms of persistent and bystander effects, we have revealed evidence of a bystander effect in vivo and with researchers at and demonstrated for the first time the molecular mechanism by which cells “remember” radiation exposure. Understanding the underlying molecular mechanisms by which radiation can induce genomic instability is fundamental to our ability to assess the biological impact of low dose radiation. Finally, in a parallel set of studies we have explored the effects of heavy iron particle radiation on large scale sequence rearrangements and we have discovered tissue specific differences in sensitivity to homologous recombination. DOE support has given rise to critical new knowledge about the biological impact of low dose rate radiation and about the underlying mechanisms that govern genomic stability in response to radiation exposure. This work has spurred interest in radiation among MIT scientists, and has fostered ongoing research projects that will continue to contribute toward our understanding of the biological effects of low dose radiation exposure.

  3. Vibration suppression, stabilization, motion planning and tracking for flexible beams

    E-Print Network [OSTI]

    Siranosian, Antranik Antonio

    2009-01-01T23:59:59.000Z

    Target System . . . . 3.2.3 Flexible Beams . . . 3.3 MotionPlanning and Tracking for Flexible Beams A Dissertationand De?ection Angle for Flexible Beams,” ASME Journal of

  4. 'Catch and Suppress' Control of Instabilities in High Performance

    Office of Science (SC) Website

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron4(SC) Mapping the ImpactSCDOE Office ofThe LifeUserWork

  5. PHASE II VAULT TESTING OF THE ARGONNE RFID SYSTEM

    SciTech Connect (OSTI)

    Willoner, T.; Turlington, R.; Koenig, R.

    2012-06-25T23:59:59.000Z

    The U.S. Department of Energy (DOE) (Environmental Management [EM], Office of Packaging and Transportation [EM-45]) Packaging and Certification Program (DOE PCP) has developed a Radio Frequency Identification (RFID) tracking and monitoring system, called ARG-US, for the management of nuclear materials packages during transportation and storage. The performance of the ARG-US RFID equipment and system has been fully tested in two demonstration projects in April 2008 and August 2009. With the strong support of DOE-SR and DOE PCP, a field testing program was completed in Savannah River Site's K-Area Material Storage (KAMS) Facility, an active Category I Plutonium Storage Facility, in 2010. As the next step (Phase II) of continued vault testing for the ARG-US system, the Savannah River Site K Area Material Storage facility has placed the ARG-US RFIDs into the 910B storage vault for operational testing. This latest version (Mark III) of the Argonne RFID system now has the capability to measure radiation dose and dose rate. This paper will report field testing progress of the ARG-US RFID equipment in KAMS, the operability and reliability trend results associated with the applications of the system, and discuss the potential benefits in enhancing safety, security and materials accountability. The purpose of this Phase II K Area test is to verify the accuracy of the radiation monitoring and proper functionality of the ARG-US RFID equipment and system under a realistic environment in the KAMS facility. Deploying the ARG-US RFID system leads to a reduced need for manned surveillance and increased inventory periods by providing real-time access to status and event history traceability, including environmental condition monitoring and radiation monitoring. The successful completion of the testing program will provide field data to support a future development and testing. This will increase Operation efficiency and cost effectiveness for vault operation. As the next step (Phase II) of continued vault testing for the ARG-US system, the Savannah River Site K Area Material Storage facility has placed the ARG-US RFIDs into the 910B storage vault. Deploying the ARG-US RFID system lends to a reduced need for manned surveillance and increased inventory periods by providing real-time access to status and event history traceability, including radiation and environmental monitoring. The successful completion of the testing program will provide field data to support future development and testing.

  6. Branching Fraction Measurements of the Color-Suppressed Decays B0bar to D(*)0 pi0, D(*)0 eta, D(*)0 omega, and D(*)0 eta_prime and Measurement of the Polarization in the Decay B0bar to D*0 omega

    SciTech Connect (OSTI)

    Lees, J.P.; Poireau, V.; Tisserand, V.; /Annecy, LAPP; Garra Tico, J.; Grauges, E.; /Barcelona U., ECM; Martinelli, M.; /INFN, Bari /Bari U.; Milanes, D.A.; /INFN, Bari; Palano, A.; Pappagallo, M.; /INFN, Bari /Bari U.; Eigen, G.; Stugu, B.; /Bergen U.; Brown, D.N.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G.; /UC, Berkeley; Koch, H.; Schroeder, T.; /Ruhr U., Bochum; Asgeirsson, D.J.; Hearty, C.; Mattison, T.S.; McKenna, J.A.; /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UC, Riverside /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /Frascati /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /Indian Inst. Tech., Guwahati /Harvard U. /Harvey Mudd Coll. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa State U. /Iowa State U. /Johns Hopkins U. /Paris U., VI-VII /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT /McGill U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /INFN, Naples /Naples U. /NIKHEF, Amsterdam /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /Padua U. /Paris U., VI-VII /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa U. /INFN, Pisa /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /Rostock U. /Rutherford /DAPNIA, Saclay /SLAC /South Carolina U. /Southern Methodist U. /Stanford U., Phys. Dept. /SUNY, Albany /Tel Aviv U. /Tennessee U. /Texas Nuclear Corp., Austin /Texas U. /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /Valencia U. /Victoria U. /Warwick U. /Wisconsin U., Madison; ,

    2012-02-14T23:59:59.000Z

    We report updated branching fraction measurements of the color-suppressed decays {bar B}{sup 0} {yields} D{sup 0}{pi}{sup 0}, D*{sup 0}{pi}{sup 0}, D{sup 0}{eta}, D*{sup 0}{eta}, D{sup 0}{omega}, D*{sup 0}{omega}, D{sup 0}{eta}', and D*{sup 0}{eta}'. We measure the branching fractions (x10{sup -4}): {Beta}({bar B}{sup 0} {yields} D{sup 0}{pi}{sup 0}) = 2.69 {+-} 0.09 {+-} 0.13, {Beta}({bar B}{sup 0} {yields} D*{sup 0}{pi}{sup 0}) = 3.05 {+-} 0.14 {+-} 0.28, {Beta}({bar B}{sup 0} {yields} D{sup 0}{eta}) = 2.53 {+-} 0.09 {+-} 0.11, {Beta}({bar B}{sup 0} {yields} D*{sup 0}{eta}) = 2.69 {+-} 0.14 {+-} 0.23, {Beta}({bar B}{sup 0} {yields} D{sup 0}{omega}) = 2.57 {+-} 0.11 {+-} 0.14, {Beta}({bar B}{sup 0} {yields} D*{sup 0}{omega}) = 4.55 {+-} 0.24 {+-} 0.39, {Beta}({bar B}{sup 0} {yields} D{sup 0}{eta}') = 1.48 {+-} 0.13 {+-} 0.07, and {Beta}({bar B}{sup 0} {yields} D*{sup 0}{eta}') = 1.49 {+-} 0.22 {+-} 0.15. We also present the first measurement of the longitudinal polarization fraction of the decay channel D*{sup 0}{omega}, f{sub L} = (66.5 {+-} 4.7 {+-} 1.5)%. In the above, the first uncertainty is statistical and the second is systematic. The results are based on a sample of (454 {+-} 5) x 10{sup 6} B{bar B} pairs collected at the {Upsilon}(4S) resonance, with the BABAR detector at the PEP-II storage rings at SLAC. The measurements are the most precise determinations of these quantities from a single experiment. They are compared to theoretical predictions obtained by factorization, Soft Collinear Effective Theory (SCET) and perturbative QCD (pQCD). We find that the presence of final state interactions is favored and the measurements are in better agreement with SCET than with pQCD.

  7. Dmitri Babikov (dmitri.babikov@mu.edu; 288-3538) Quantum Origin of Anomalous Isotope Effect in Ozone Formation

    E-Print Network [OSTI]

    Reid, Scott A.

    of photocatalytic hybrid materials for solar energy conversion James Kincaid (james.kincaid@mu.edu; 288 in Ozone Formation Mixed Quantum/Classical Theory for Collisional Energy Transfer Computational Study-Halons Mark Steinmetz (mark.steinmetz@mu.edu; 288-3535) Photochemically Removable Protecting Groups Qadir

  8. EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CERN-EP/98-xxx

    E-Print Network [OSTI]

    Boyer, Edmond

    EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CERN-EP/98-xxx June 14, 1998 Measurement of beauty hadrons, b ! Xu`, has been performed using almost two million hadronic Z decays collected by the L symmetry. Several measurements of jVubj performed at the (4S) exist to date. The CLEO [4] and ARGUS [5

  9. Creating Artificial Radiation Belts in the Lab

    E-Print Network [OSTI]

    Mauel, Michael E.

    Current: Trapped, High- Protons (15-250 keV) · Greatly intensified during geomagnetic storms · Ti ~ 7Te Jeff #12;Outline · The Earth's radiation belts and ring current · Fast-electron interchange instability to measure the artificial radiation belt produced by the Argus explosions (1958). (Explosions continued

  10. REAL 380 -REAL ESTATE INVESTMENT ANALYSIS Fall, 2013; MW 4:00 5:15, 320 Beatty Center

    E-Print Network [OSTI]

    Young, Paul Thomas

    forecasting and risk analysis." Objectives REAL 380 is an advanced course focusing on real estate investment analysis and decision-making. By the end of the course the students will be vary familiar, students will learn the basics of ARGUS as an analytical tool for analysis. Prerequisite Junior standing

  11. Mark Humayun Photograph by Jill Greenberg

    E-Print Network [OSTI]

    Valero-Cuevas, Francisco

    .com/science/health/breakthroughs/next-gen-digital-sight-could- cure-blindness Next Gen Digital Sight Could Cure Blindness The Brilliant Idea: An artificial retina to receive the Argus II artificial retina. In a healthy human eye, 125 million photoreceptors at the back's left eye and lift the saran-wrap-like membrane that covers it, called the conjunctiva. He

  12. SA Time: 16:38 R/$ 9.27 R/ 12.57 R/ 15.84 Gold $/oz 899.85 JSE Alsi 20,465.22 More indicators Article Search

    E-Print Network [OSTI]

    Rogers, John A.

    Panels Save $1000's on Energy Bills, Build Solar Panels, as seen on CNN, $49.9 www.Earth4EnergyGuide.com Solar Energy Panels Resources and information on solar energy panels. Compare and save! www.SolarPanel Subscriptions Cape Argus Cape Times Daily News Isolezwe Post Pretoria News Honda Solar Cell Learn about Honda

  13. Argonne National Laboratory U.S. Department of Energy

    E-Print Network [OSTI]

    Kemner, Ken

    Savannah River Site, Aiken, SC (a plutonium storage facility), and at the Nevada National Security Site#12;Argonne National Laboratory U.S. Department of Energy ARG-US RFID Friday, April 19, 2013 1 Case in 2011. 3 Results 3.1 Commercialization In July 2012, Argonne National Laboratory and Evigia Systems, Inc

  14. MIS @ UT Dallas Creating Value Through IT -Driven Business Intelligence

    E-Print Network [OSTI]

    O'Toole, Alice J.

    . Patient Point WebFilings, LLC Aptiva Corporation ESRI PayPal, Inc. World Wide Technology Argus Fischer & Company PDS Tech. Xenosoft Technologies, Inc. Ariba, Inc. Fiserv PDX Inc Yellowbox Solutions AssociationCoopers Zimmer, Inc. Automation Solutions, Inc. GTL USA, Inc. Propelsys Technologies ZINI'S Pizzeria Axometrics

  15. Overcoming dendritic cell-mediated suppression of T cell responses in a prostate tumor environment

    E-Print Network [OSTI]

    Higham, Eileen M

    2010-01-01T23:59:59.000Z

    Prostate cancer is the most prevalent malignancy in American men, leading to significant mortality each year. This is in part due to a lack of effective treatments for advanced disease. The prostate is considered an ideal ...

  16. 5-Hydroxy-L-tryptophan suppresses food intake in food-deprived and stressed rats

    E-Print Network [OSTI]

    Wurtman, Richard

    Research Center, Massachusetts Institute of Technology, Cambridge, MA, USA c Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA Received 22 January 2003 deprivation and a standardized stress (tail pinch), and on plasma 5-HTP levels in humans. In rats, 5-HTP (3

  17. Saccadic suppression during reading activity : is the spill-over effect weaker after a longer saccade? 

    E-Print Network [OSTI]

    Yatabe, Kiyomi

    2006-01-01T23:59:59.000Z

    Although it has generally thought that the duration of saccades should be subtracted from the reading time in eye movement research, Irwin (1998) has demonstrated that lexical processing such as word recognition is not ...

  18. MicroRNAs-449a and -449b exhibit tumor suppressive effects in retinoblastoma

    SciTech Connect (OSTI)

    Martin, Alissa [Division of Hematology, Oncology, and Stem Cell Transplantation, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611 (United States)] [Division of Hematology, Oncology, and Stem Cell Transplantation, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611 (United States); Jones, Aunica [Cancer Biology and Epigenomics Program, Ann and Robert H. Lurie Children’s Hospital of Chicago Research Center, Chicago, IL 60611 (United States)] [Cancer Biology and Epigenomics Program, Ann and Robert H. Lurie Children’s Hospital of Chicago Research Center, Chicago, IL 60611 (United States); Bryar, Paul J. [Departments of Ophthalmology and Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 (United States)] [Departments of Ophthalmology and Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 (United States); Mets, Marilyn [Division of Ophthalmology, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611 (United States) [Division of Ophthalmology, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611 (United States); Department of Ophthalmology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611 (United States); Weinstein, Joanna [Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611 (United States) [Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611 (United States); Division of Hematology, Oncology, and Stem Cell Transplantation, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611 (United States); Zhang, Gang [Biostatistics Research Core, Ann and Robert H. Lurie Children’s Hospital of Chicago Research Center, Chicago, IL 60611 (United States)] [Biostatistics Research Core, Ann and Robert H. Lurie Children’s Hospital of Chicago Research Center, Chicago, IL 60611 (United States); Laurie, Nikia A., E-mail: n-laurie@northwestern.edu [Cancer Biology and Epigenomics Program, Ann and Robert H. Lurie Children’s Hospital of Chicago Research Center, Chicago, IL 60611 (United States); Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611 (United States)

    2013-11-01T23:59:59.000Z

    Highlights: •We validate miR-449a/b expression in primary human retinoblastomas and cell lines. •Exogenous miRs-449a/b inhibited proliferation in retinoblastoma cell lines. •Exogenous miRs-449a/b increased apoptosis in retinoblastoma cell lines. •miRs-449a/b could serve as viable therapeutic targets for retinoblastoma treatment. -- Abstract: Retinoblastoma is the most common pediatric cancer of the eye. Currently, the chemotherapeutic treatments for retinoblastoma are broad-based drugs such as vincristine, carboplatin, or etoposide. However, therapies targeted directly to aberrant signaling pathways may provide more effective therapy for this disease. The purpose of our study is to illustrate the relationship between the expressions of miRs-449a and -449b to retinoblastoma proliferation and apoptosis. We are the first to confirm an inhibitory effect of miR-449a and -449b in retinoblastoma by demonstrating significantly impaired proliferation and increased apoptosis of tumor cells when these miRNAs are overexpressed. This study suggests that these miRNAs could serve as viable therapeutic targets for retinoblastoma treatment.

  19. The effect of an evaporation suppressant upon the liquid film oxygen transfer coefficient

    E-Print Network [OSTI]

    Amad, Mohamad Towfic

    1967-01-01T23:59:59.000Z

    " ? By Winkler Method 32 Oxygen Transfer Coefficient At 21'C Using Distilled Water Without "Aquasave" ? By Winkler Method 33 Oxygen Transfer Coefficient At 36'C Using Distilled Water With "Aquasave" ? By Winkler Method 34 Oxygen Transfer Coefficient At 36'C... Using Distilled Water Without "Aquasave" ? By Winkler Method 35 Oxygen Transfer Coefficient At 21'C Using Blended Water With "Aquasave" ? By D. O. Meter 37 10. Oxygen Transfer Coefficient At 21'C Using Blended Water Without "Aquasave" ? By D. 0...

  20. Chaos suppression in flows using proportional pulses in the system variables M. A. Matias*

    E-Print Network [OSTI]

    Matías, Manuel A.

    ´as* Departamento de Qui´mica Fi´sica, Universidad de Salamanca, E-37008 Salamanca, Spain J. Gu¨e´mez Departamento. Gu¨e´mez, Phys. Rev. Lett. 72, 1455 1994 is presented. The method does not require any previous

  1. Experimental results of water film formation on various fuel forms from a fire suppression system

    SciTech Connect (OSTI)

    Ross, R.H.; Davis, J.R.

    1993-12-31T23:59:59.000Z

    The purpose of the study was to determine the thickness and coverage of water film formations on various materials during fire sprinkler deluge. An exhaustive literature search revealed that no applicable research data exists that governs water film formations from fire protection systems. Therefore, a controlled, infield, mockup was created to predict the thickness and coverage of water film on fissile material forms. This paper discusses the background, experimental procedure and the characterization of these water films.

  2. The effects of acceptance and suppression on anticipation and receipt of painful stimulation

    E-Print Network [OSTI]

    Gross, James J.

    (Miles & Gross, 1999) and/or experiential (Campbell-Sills, Barlow, Brown, & Hofmann, 2006; Feldner (Campbell-Sills et al., 2006; Gross & Levenson, 1993, 1997; Gross, 1998, 2002; Hofmann, Heering, Sawyer

  3. Suppression of Phase Separation in LiFePO 4 Nanoparticles During Battery Discharge

    E-Print Network [OSTI]

    Bai, Peng

    Using a novel electrochemical phase-field model, we question the common belief that LiXFePO? nanoparticles always separate into Li-rich and Li-poor phases during battery discharge. For small currents, spinodal decomposition ...

  4. Effects of Aging on Experimentally Instructed Detached Reappraisal, Positive Reappraisal, and Emotional Behavior Suppression

    E-Print Network [OSTI]

    Levenson, Robert W.

    , 2005; Coats & Blanchard-Fields, 2008) and problem solving when facing a nonsocial stressor (e.g., Blanchard- Fields, 2007; Coats & Blanchard-Fields, 2008). Emotion regulation is not a single process is typically geared toward reducing negative emotion, and evidence that overall levels of negative emotion

  5. Suppressible pinning of Abrikosov vortices : effects of magnetic vortex arrays on thin superconducting films

    E-Print Network [OSTI]

    Smith, Kevin Daniel

    2008-01-01T23:59:59.000Z

    212507 (2002). [10] M.I. Montero, J.J. Akerman, A. Varilci,J.E. Villegas, M.I. Montero, C. -P. Li and I.K. Schuller,Y. Bruynserede, M.I. Montero, I.K. Schuller, Europhys. Lett.

  6. Metallic contacts with individual Ru nanowires prepared by electrochemical deposition and the suppression of superconductivity

    E-Print Network [OSTI]

    conducting. Nanowires of Ru were grown in commercial, track- etched polycarbonate membranes with a nominal. We have prepared Ru nanowires by electrochemical deposition in porous polycarbonate membranes on all super- conducting nanowires prepared by electrochemical deposi- tion have been limited to arrays

  7. Suppression of thermoacoustic instabilities in a swirl combustor through microjet air injection

    E-Print Network [OSTI]

    LaBry, Zachary Alexander

    2010-01-01T23:59:59.000Z

    Thermoacoustic or combustion instability, a positive feedback loop coupling heat release rate and acoustic oscillations in a combustor, is one of the greatest challenges currently facing the development of new gas turbine ...

  8. Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth

    E-Print Network [OSTI]

    Maizels, Rick

    of the lungs.5 Most asthmatic individuals are characterized by a T helper type 2 (Th2) response to allergens, with increased type 2 cytokines and eosinophilia in the lungs. Recently, the critical roles of both the airway of lung eosinophilia to Alternaria extract in the early (o3 days post administration) phase can

  9. Progress in year 2000 1. Superfluid suppression of impurity scattering in a Bose-Einstein

    E-Print Network [OSTI]

    was dramatically reduced when the velocity of the impurities was reduced below the speed of sound of the condensate of dissipation was found at a critical velocity of about 10 % of the speed of sound which corrects the higher or rotons in the case of liquid helium-4. We could create impurity atoms in a trapped BEC by transferring

  10. Distributed control in a mean-field cortical network model: Implications for seizure suppression

    E-Print Network [OSTI]

    Ching, ShiNung

    Brain electrical stimulation (BES) has long been suggested as a means of controlling pathological brain activity. In epilepsy, control of a spatially localized source, the seizure focus, may normalize neuronal dynamics. ...

  11. Sulfur pollution suppression of the wetland methane source in the 20th and 21st centuries

    E-Print Network [OSTI]

    , which is reduced to CH4. Acetate-fermenting MA tend to dominate in more nutrient-rich peatlands (SO4 2 -S) deposition, within the range of global acid deposition. We apply a model% smaller than it would be in the absence of global acid deposition. Our findings suggest that by 2030

  12. Transcription Factor Amr1 Induces Melanin Biosynthesis and Suppresses Virulence in Alternaria brassicicola

    SciTech Connect (OSTI)

    Cho, Yangrae; Srivastava, Akhil; Ohm, Robin A.; Lawrence, Christopher B.; Wang, Koon-Hui; Grigoriev, Igor V.; Marahatta, Sharadchandra P.

    2012-05-01T23:59:59.000Z

    Alternaria brassicicola is a successful saprophyte and necrotrophic plant pathogen. Several A. brassicicola genes have been characterized as affecting pathogenesis of Brassica species. To study regulatory mechanisms of pathogenesis, we mined 421 genes in silico encoding putative transcription factors in a machine-annotated, draft genome sequence of A. brassicicola. In this study, targeted gene disruption mutants for 117 of the transcription factor genes were produced and screened. Three of these genes were associated with pathogenesis. Disruption mutants of one gene (AbPacC) were nonpathogenic and another gene (AbVf8) caused lesions less than half the diameter of wild-type lesions. Unexpectedly, mutants of the third gene, Amr1, caused lesions with a two-fold larger diameter than the wild type and complementation mutants. Amr1 is a homolog of Cmr1, a transcription factor that regulates melanin biosynthesis in several fungi. We created gene deletion mutants of ?amr1 and characterized their phenotypes. The ?amr1 mutants used pectin as a carbon source more efficiently than the wild type, were melanin-deficient, and more sensitive to UV light and glucanase digestion. The AMR1 protein was localized in the nuclei of hyphae and in highly melanized conidia during the late stage of plant pathogenesis. RNA-seq analysis revealed that three genes in the melanin biosynthesis pathway, along with the deleted Amr1 gene, were expressed at low levels in the mutants. In contrast, many hydrolytic enzyme-coding genes were expressed at higher levels in the mutants than in the wild type during pathogenesis. The results of this study suggested that a gene important for survival in nature negatively affected virulence, probably by a less efficient use of plant cell-wall materials. We speculate that the functions of the Amr1 gene are important to the success of A. brassicicola as a competitive saprophyte and plant parasite.

  13. Evidence for Insulin Suppression of Baseline Luteinizing Hormone in Women with Polycystic

    E-Print Network [OSTI]

    Lawson, Mark A.

    doses of GnRH during a fixed rate of insulin infusion and LH responses to a fixed dose of GnRH during varying doses of insulin infusion were analyzed for contributing factors. Patients and Setting: Eighteen and during insulin infusion at theGeneral Clinical Research Center, University of California, San Diego. Main

  14. Thoracic Low-dose CT Image Processing Using an Artifact Suppressed Large-scale Nonlocal Means

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    The lung and bronchus cancer is a leading cause of cancer death in the United States with a mortality rate

  15. A Hybrid Stimulation Strategy for Suppression of Spiral1 Waves in Cardiac Tissue2

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    , approximately 1% of the adult population of the United States.15 Recent clinical trial evidence suggests fibrillation (VF), responsible for4 sudden cardiac death, can be considered as a lethal "three have limited efficacy as the AF re-25 currence rate is high, and are limited by numerous side effects

  16. Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent

    E-Print Network [OSTI]

    Pike, J. Wesley

    of estrogen's beneficial effects in preventing post- menopausal osteoporosis (1­3). Studies also suggest 30, 2000) Loss of ovarian function following menopause results in a sub- stantial increase in bone- sive loss of trabecular bone mass and eventually osteoporosis, in part the result of increased

  17. Androgens Suppress Osteoclast Formation Induced by RANKL and Macrophage-Colony Stimulating Factor

    E-Print Network [OSTI]

    Pike, J. Wesley

    -Jun essential for osteoclast differentiation. (Endocrinology 142: 3800­3808, 2001) OSTEOPOROSIS IS A disease of osteoporosis have yet to be identified. Bone loss, however, most often occurs as a result of an imbalance­4). Two of the most significant determinants of progressive bone loss and osteoporosis in both males

  18. attenuated cocaine-induced suppression: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topic Index 181 Three-Dimensional Compressional Attenuation Model (QP) for the Salton Trough, Southern California Geosciences Websites Summary: -frequency decay rate of...

  19. Suppressing Riser-Based Slugging in Multiphase Flow by State Feedback

    E-Print Network [OSTI]

    Foss, Bjarne A.

    of the system, x1 is the total mass of gas in the volume upstream of the riser base (volume one), x2 is the total mass of gas in the riser (volum or vertical pipe sections, and is potentially damaging to downstream processing equipment such as separators

  20. Energy Dependence of Solar Neutrino Suppression and Bounds on the Neutrino Magnetic Moment

    E-Print Network [OSTI]

    Joao Pulido; Ana M. Mourao

    1998-03-02T23:59:59.000Z

    An analysis of neutrino electron scattering as applied to the SuperKamiokande solar neutrino experiment with the data from the Homestake experiment leads to an upper bound on the neutrino magnetic moment in the range $\\mu_{\

  1. A Fusing Switch for Fault Suppression in the SNS High Voltage Converter Modulators

    SciTech Connect (OSTI)

    Kemp, Mark A.; Burkhart, Craig; Nguyen, Minh N.; /SLAC; Anderson, David E.; /Oak Ridge

    2009-08-03T23:59:59.000Z

    The High Voltage Converter Modulators (HVCMs) at the Spallation Neutron Source (SNS) have operated in excess of a combined 250,000 hours. Performance and reliability improvements to the HVCM are ongoing to increase modulator availability as accelerator system demands increase. There is a relatively large amount of energy storage in the HVCMs, {approx}180 kJ. This energy has the potential to dump into unsuppressed faults, cause damage, and increase the time to repair. The 'fusing switch' concept involves isolation of this stored energy from the location of the most common faults. This paper introduces this concept and its application to the HVCMs.

  2. Emotion Regulation and Vulnerability to Depression: Spontaneous Versus Instructed Use of Emotion Suppression and Reappraisal

    E-Print Network [OSTI]

    Gross, James J.

    Emotion Regulation and Vulnerability to Depression: Spontaneous Versus Instructed Use of Emotion vulnerability is related to difficulties with emotion regulation by comparing recovered-depressed and never of emotion regulation strategies. In the second phase, sad mood was induced using a film clip, and the degree

  3. Phototactic personality in fruit flies and its suppression by serotonin and white

    E-Print Network [OSTI]

    de Bivort, Benjamin

    one choice tube leads to a lit light-emitting diode (LED) (Fig. 1A, Fig. S1 A and B, and Movie S1). Af

  4. Advanced phase modulation techniques for stimulated brillouin scattering suppression in fiber optic parametric amplifiers

    E-Print Network [OSTI]

    Coles, James

    2009-01-01T23:59:59.000Z

    s-1. —Measurement Results Integ Pwr: -Markers B 190.3398 THzMeasurement Results Integ Pwr: 0.375 dBrn MeanWL: 1575.03832

  5. Oxidative stress suppression by luteolin-induced heme oxygenase-1 expression

    SciTech Connect (OSTI)

    Sun, Gui-bo; Sun, Xiao; Wang, Min [Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193 (China)] [Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193 (China); Ye, Jing-xue [Jilin Agricultural University, No.2888, Xincheng Street, Changchun, 130021, Jilin (China)] [Jilin Agricultural University, No.2888, Xincheng Street, Changchun, 130021, Jilin (China); Si, Jian-yong [Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193 (China)] [Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193 (China); Xu, Hui-bo [Academy of Chinese Medical Sciences of Jilin Province, Gongnongda road 1745, Changchun, 130021, Jiblin (China)] [Academy of Chinese Medical Sciences of Jilin Province, Gongnongda road 1745, Changchun, 130021, Jiblin (China); Meng, Xiang-bao; Qin, Meng; Sun, Jing [Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193 (China)] [Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193 (China); Wang, Hong-wei, E-mail: hwang@nju.edu.cn [Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093 (China)] [Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093 (China); Sun, Xiao-bo, E-mail: sunsubmit@163.com [Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193 (China)] [Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193 (China)

    2012-12-01T23:59:59.000Z

    Luteolin, a flavonoid that exhibits antioxidative properties, exerts myocardial protection effects. However, the underlying molecular mechanisms are not yet fully understood. To investigate the effects of luteolin on myocardial injury protection and its possible mechanisms, a myocardial injury model was established with intragastric administration of 4 mg/kg isoproterenol (ISO) to male Sprague–Dawley rats (200–220 g) daily for 2 days. We found that pretreatment of luteolin (160, 80 and 40 mg/kg, i.g., respectively) daily for 15 days can prevent ISO-induced myocardial damage, including decrease of serum cardiac enzymes, improvement electrocardiography and heart vacuolation. Luteolin also improved the free radical scavenging and antioxidant potential, suggesting one possible mechanism of luteolin-induced cardio-protection is mediated by blocking the oxidative stress. To clarify the mechanisms, we performed the in vitro study by hydrogen peroxide (H{sub 2}O{sub 2})-induced cytotoxicty model in H9c2 cells. We found that luteolin pretreatment prevented apoptosis, increased the expression of heme oxygenase-1 (HO-1), and enhanced the binding of Nrf2 to the antioxidant response element, providing an adaptive survival response against H{sub 2}O{sub 2}-derived oxidative cytotoxicity. The addition of Znpp, a selective HO-1 competitive inhibitor, reduced the cytoprotective ability of luteolin, indicating the vital role of HO-1 on these effects. Luteolin also activated Akt and ERK, whereas the addition of LY294002 and U0126, the pharmacologic inhibitors of PI3K and ERK, attenuated luteolin-induced HO-1 expression and cytoprotective effect. Taken together, the above findings suggest that luteolin protects against myocardial injury and enhances cellular antioxidant defense capacity through the activation of Akt and ERK signal pathways that leads to Nrf2 activation, and subsequently HO-1 induction. -- Highlights: ? Luteolin prevents isoproterenol-induced myocardial damage. ? Luteolin enhances cellular antioxidant defense capacity. ? Luteolin increases the expression of heme oxygenase-1 protein levels. ? Luteolin activates Akt and ERK signal pathways.

  6. Influence of Transpiration Suppressants, Sprinkler Irrigation and Moisture Levels on Transpiration and Evapotranspiration 

    E-Print Network [OSTI]

    Gerard, C. J.

    1970-01-01T23:59:59.000Z

    and net radiation data indicated that reflective treatment on tomatoes was effective in reflecting the incoming solar radiation in 1969. Thermoelectric Data Sap flow as influenced by treatments and climatic conditions was evaluated with a thermoelectric...

  7. Study of high transverse momentum charged particle suppression in heavy ion collisions at LHC

    E-Print Network [OSTI]

    Yoon, Andre Sungho

    2012-01-01T23:59:59.000Z

    The charged particle spectrum at large transverse momentum (PT), dominated by hadrons originating from parton fragmentation, is an important observable for studying the properties of the hot, dense medium produced in ...

  8. Technical evaluation of equipment maintenance on fire alarm detection, suppression, and signaling

    SciTech Connect (OSTI)

    Korslund, S.M.

    1994-10-01T23:59:59.000Z

    This document delineates the application of WHC-CM-4-3, Program E-2 to Fire Systems on the Hanford Site.

  9. Bcl-2 Suppresses Sarcoplasmic/Endoplasmic Reticulum Ca2+-ATPase Expression in Cystic Fibrosis Airways

    E-Print Network [OSTI]

    Ahmad, Shama; Ahmad, Aftab; Dremina, Elena S.; Sharov, Victor S.; Guo, Xiaoling; Jones, Tara N.; Loader, Joan E.; Tatreau, Jason R.; Perraud, Anne-Laure; Schö neich, Christian; Randell, Scott H.; White, Carl W.

    2009-05-01T23:59:59.000Z

    signaling and apoptosis in CF. These findings decrease the likelihood of therapeutic benefit of SERCA inhibition in CF. Keywords: cystic fibrosis; SERCA2; pulmonary epithelium; ER Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis... in the endoplasmic reticulum (ER) and rapid intracellular degradation. For these reasons, DF508 CFTR fails to function as a cAMP-activated Cl2 channel (1). Previous reports have indicated that sarcoendoplasmic re- ticulum calcium ATPase (SERCA) inhibitors can...

  10. Suppressing the influence of additive noise on the Kalman gain for low residual noise speech enhancement

    E-Print Network [OSTI]

    present a detailed analysis of the Kalman filter for the application of speech enhancement and identify: Kalman filtering; Speech enhancement; Linear prediction; Dolph-Chebycher windows 1. Introduction In the problem of speech enhancement, where a speech signal corrupted by noise is given, we are primarily

  11. Automated suppression of errors in LTP-II slope measurements with x-ray optics

    E-Print Network [OSTI]

    Ali, Zulfiqar

    2012-01-01T23:59:59.000Z

    precise reflective X-ray optics,” Nucl. Instrum. and Methods70 (2001). [2] P. Z. Takacs, “X- ray optics metrology,” in [Handbook of Optics], 3rd ed. , Vol. V, M. Bass, Ed. ,

  12. Automated suppression of errors in LTP-II slope measurements with x-ray optics

    E-Print Network [OSTI]

    Ali, Zulfiqar

    2011-01-01T23:59:59.000Z

    slope measurements with x-ray optics Zulfiqar Ali, Curtis L.with state-of-the-art x-ray optics. Significant suppressionscanning, metrology of x-ray optics, deflectometry Abstract

  13. Dust suppression results using mineral oil applications on corn and milo

    E-Print Network [OSTI]

    Wardlaw, Herman Douglas

    1987-01-01T23:59:59.000Z

    grain dust explosion, grain dust (less than 100 microns (pm) In aerodynamic diameter) must be in suspension at or above the minimum explosive concentration (MEC). The MEC for grain dust will vary depending upon moisture context, particle size... will be present in any grain handling facility. Containment restricts grain dust from dispersing, which allows for the development of the MEC. The NEC is so highly concentrated that without containment, it is unlikely to occur in a grain handling facility...

  14. Modeling and Performance of Pyroelectric Detector Lithium Niobate under Ringing Signal Suppression

    E-Print Network [OSTI]

    Peng, Gary Meng Kiang

    2013-01-01T23:59:59.000Z

    LiNbO 3 ) is an excellent photo sensor that can be used inin narrow band gap photo sensors. The added cooling

  15. Method and system for suppression of stimulated Raman scattering in laser materials

    DOE Patents [OSTI]

    Caird, John A; Bayramian, Andrew J; Ebbers, Christopher A

    2013-11-19T23:59:59.000Z

    A composition of matter is provided having the general chemical formula K(H,D).sub.2P(.sup.16O.sub.x,.sup.18O.sub.y).sub.4, where x<0.998 or y>0.002, and x+y.apprxeq.1. Additionally, a method of fabricating an optical material by growth from solution is provided. The method includes providing a solution including a predetermined percentage of (H,D).sub.2.sup.16O and a predetermined percentage of (H,D).sub.2.sup.18O, providing a seed crystal, and supporting the seed crystal on a platform. The method also includes immersing the seed crystal in the solution and forming the optical material. The optical material has the general chemical formula K(H,D).sub.2P(.sup.16O.sub.x,.sup.18O.sub.y).sub.4, where x<0.998 or y>0.002, and x+y.apprxeq.1.

  16. Doping suppression and mobility enhancement of graphene transistors fabricated using an adhesion promoting dry transfer process

    SciTech Connect (OSTI)

    Cheol Shin, Woo; Hun Mun, Jeong; Yong Kim, Taek; Choi, Sung-Yool; Jin Cho, Byung, E-mail: bjcho@kaist.edu, E-mail: tskim1@kaist.ac.kr [Department of Electrical Engineering, Graphene Research Center, KAIST, 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701 (Korea, Republic of); Yoon, Taeshik; Kim, Taek-Soo, E-mail: bjcho@kaist.edu, E-mail: tskim1@kaist.ac.kr [Department of Mechanical Engineering, Graphene Research Center, KAIST, 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701 (Korea, Republic of)] [Department of Mechanical Engineering, Graphene Research Center, KAIST, 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701 (Korea, Republic of)

    2013-12-09T23:59:59.000Z

    We present the facile dry transfer of graphene synthesized via chemical vapor deposition on copper film to a functional device substrate. High quality uniform dry transfer of graphene to oxidized silicon substrate was achieved by exploiting the beneficial features of a poly(4-vinylphenol) adhesive layer involving a strong adhesion energy to graphene and negligible influence on the electronic and structural properties of graphene. The graphene field effect transistors (FETs) fabricated using the dry transfer process exhibit excellent electrical performance in terms of high FET mobility and low intrinsic doping level, which proves the feasibility of our approach in graphene-based nanoelectronics.

  17. Two Approaches to Repetition Suppression Uta Noppeney1,2* and Will D. Penny1

    E-Print Network [OSTI]

    Penny, Will

    . These discrepancies might be due to the different efficien- cies with which the particular contrasts were estimated

  18. Observation of the Cabibbo-suppressed charmed baryon decay ?c(+)?p?

    E-Print Network [OSTI]

    Baringer, Philip S.

    1996-02-01T23:59:59.000Z

    .04560.011 Z? enczykowski 0.023 Ko¨rner and Kra¨mer @6# 0.05 Datta @8# 0.01 aReference @7#, using Ref. @1# for B(Lc1!pK2p1).MeV/c to 1.1 GeV/c falling off to below 10% by 2.5 GeV/c . For kaons the particle-ID efficiency remains relatively flat at about 95...(pf)/B(pKK). The final results appear in Table II, along with those from NA32 @9# and E687 @10# and theoretical predictions from Cheng and Tseng @5#, Ko¨rner and Kra¨mer @6#, Z? enczykowski @7#, and Datta @8#. From Table I we also find B(Lc1!pK2K1@non-f#!50...

  19. Advantage of suppressed non-Langevin recombination in low mobility organic solar cells

    SciTech Connect (OSTI)

    Stolterfoht, Martin; Armin, Ardalan; Pandey, Ajay K.; Burn, Paul L.; Meredith, Paul; Pivrikas, Almantas, E-mail: almantas.pivrikas@uq.edu.au [Centre for Organic Photonics and Electronics (COPE), School of Chemistry and Molecular Biosciences and School of Mathematics and Physics, The University of Queensland, Brisbane 4072 (Australia); Philippa, Bronson; White, Ronald D. [School of Engineering and Physical Sciences, James Cook University, Townsville 4811 (Australia)

    2014-07-07T23:59:59.000Z

    Photovoltaic performance in relation to charge transport is studied in efficient (7.6%) organic solar cells (PTB7:PC{sub 71}BM). Both electron and hole mobilities are experimentally measured in efficient solar cells using the resistance dependent photovoltage technique, while the inapplicability of classical techniques, such as space charge limited current and photogenerated charge extraction by linearly increasing voltage is discussed. Limits in the short-circuit current originate from optical losses, while charge transport is shown not to be a limiting process. Efficient charge extraction without recombination can be achieved with a mobility of charge carriers much lower than previously expected. The presence of dispersive transport with strongly distributed mobilities in high efficiency solar cells is demonstrated. Reduced non-Langevin recombination is shown to be beneficial for solar cells with imbalanced, low, and dispersive electron and hole mobilities.

  20. Direct adaptive suppression of multiple unknown vibrations using an inertial actuator

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    principle and the Youla- Kucera parametrization. Index Terms-- direct adaptive regulation, internal model realization are practically constant. The correspond- ing "control plant model" to be used for control design are in the context of an adaptive regulation problem with a known plant model and an unknown disturbance model

  1. Suppressing tin whisker growth in lead-free solders and platings

    DOE Patents [OSTI]

    Hoffman, Elizabeth N; Lam, Poh-Sang

    2014-04-29T23:59:59.000Z

    A process of irradiation Sn containing Pb-free solder to mitigate whisker formation and growth thereon is provided. The use of gamma radiation such as cobalt-60 has been applied to a substrate of Sn on copper has been found to change the morphology of the crystalline whisker growth to a more truncated hillock pattern. The change in morphology greatly reduces the tendency of whiskers to contribute to electrical short-circuits being used as a Pb-free solder system on a copper substrate.

  2. $J/\\psi$ production and suppression in high energy proton-nucleus collisions

    E-Print Network [OSTI]

    Ma, Yan-Qing; Zhang, Hong-Fei

    2015-01-01T23:59:59.000Z

    We apply a Color Glass Condensate+Non-Relativistic QCD (CGC+NRQCD) framework to compute $J/\\psi$ production in deuteron-nucleus collisions at RHIC and proton-nucleus collisions at the LHC. Our results match smoothly at high $p_\\perp$ to a next-to-leading order perturbative QCD + NRQCD computation. Excellent agreement is obtained for $p_\\perp$ spectra at RHIC and LHC for central and forward rapidities, as well as for the normalized ratio $R_{pA}$ of these results to spectra in proton-proton collisions. In particular, we observe that the $R_{pA}$ data is strongly bounded by our computations of the same for each of the individual NRQCD channels; this result provides strong evidence that our description is robust against uncertainties in initial conditions and hadronization mechanisms.

  3. Vibration Suppression and Flywheel Energy Storage in a Drillstring Bottom-Hole-Assembly

    E-Print Network [OSTI]

    Saeed, Ahmed

    2012-07-16T23:59:59.000Z

    , and environmental disposal. Extreme and harsh downhole conditions necessitate that the flywheel module withstands temperatures and pressures exceeding 300 ?F and 20 kpsi, respectively, as well as violent vibrations encountered during drilling. Moreover, the flywheel...

  4. acid-induced growth suppression: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    although they did possess fewer eggs. Daphnia responses to chemicals from either roach or Elodea Burks, Romi 3 Synergistic effect of obesity and lipid ingestion in...

  5. NF-{kappa}B suppresses HIF-1{alpha} response by competing for P300 binding

    SciTech Connect (OSTI)

    Mendonca, Daniela B.S., E-mail: daniela_mendonca@dentistry.unc.edu [Universidade Catolica de Brasilia, Pos-Graduacao em Ciencias Genomicas e Biotecnologia, SGAN Quadra 916, Av. W5 Norte, 70790-160 Brasilia, DF (Brazil); Bone Biology and Implant Therapy Laboratory, Department of Prosthodontics, University of North Carolina at Chapel Hill, 330 Brauer Hall, CB 7450, Chapel Hill, NC 27599 (United States); Mendonca, Gustavo [Universidade Catolica de Brasilia, Pos-Graduacao em Ciencias Genomicas e Biotecnologia, SGAN Quadra 916, Av. W5 Norte, 70790-160 Brasilia, DF (Brazil) [Universidade Catolica de Brasilia, Pos-Graduacao em Ciencias Genomicas e Biotecnologia, SGAN Quadra 916, Av. W5 Norte, 70790-160 Brasilia, DF (Brazil); Bone Biology and Implant Therapy Laboratory, Department of Prosthodontics, University of North Carolina at Chapel Hill, 330 Brauer Hall, CB 7450, Chapel Hill, NC 27599 (United States); Aragao, Francisco J.L. [Universidade Catolica de Brasilia, Pos-Graduacao em Ciencias Genomicas e Biotecnologia, SGAN Quadra 916, Av. W5 Norte, 70790-160 Brasilia, DF (Brazil) [Universidade Catolica de Brasilia, Pos-Graduacao em Ciencias Genomicas e Biotecnologia, SGAN Quadra 916, Av. W5 Norte, 70790-160 Brasilia, DF (Brazil); Embrapa Recursos Geneticos e Biotecnologia, Laboratorio de Introducao e Expressao de Genes, PqEB W5 Norte, 70770-900 Brasilia, DF (Brazil); Cooper, Lyndon F., E-mail: lyndon_cooper@dentistry.unc.edu [Bone Biology and Implant Therapy Laboratory, Department of Prosthodontics, University of North Carolina at Chapel Hill, 330 Brauer Hall, CB 7450, Chapel Hill, NC 27599 (United States)

    2011-01-28T23:59:59.000Z

    Research highlights: {yields} p65 completely blocked HIF-1{alpha} activity at the HRE on different cell lines. {yields} p65 caused minor changes in HIF-1{alpha} and HIF-1{alpha} target genes mRNA expression. {yields} p65 reduced transcription of VEGF promoter. {yields} p65 competes with HIF-1{alpha} for p300. -- Abstract: Hypoxia has emerged as a key determinant of osteogenesis. HIF-1{alpha} is the transcription factor mediating hypoxia responses that include induction of VEGF and related bone induction. Inflammatory signals antagonize bone repair via the NF-{kappa}B pathway. The present investigation explored the functional relationship of hypoxia (HIF-1{alpha} function) and inflammatory signaling (NF-{kappa}B) in stem like and osteoprogenitor cell lines. The potential interaction between HIF-1{alpha} and NF-{kappa}B signaling was explored by co-transfection studies in hFOB with p65, HIF-1{alpha} and 9x-HRE-luc or HIF-1{alpha} target genes reporter plasmids. Nuclear cross-talk was directly tested using the mammalian Gal4/VP16 two-hybrid, and confirmed by co-immunoprecipitation/western blotting assays. The results show that inflammatory stimulation (TNF-{alpha} treatment) causes a marked inhibition of HIF-1{alpha} function at the HRE in all cell lines studied. Also, co-transfection with p65 expression vector leads to reduced hVEGFp transcription after DFO-induced hypoxia. However, TNF-{alpha} treatment had little effect on HIF-1{alpha} mRNA levels. The functional interaction of Gal4-HIF-1{alpha} and VP16-p300 fusion proteins is effectively blocked by expression of p65 in a dose dependent manner. It was concluded that NF-{kappa}B-mediated inflammatory signaling is able to block HIF-1{alpha} transactivation at HRE-encoding genes by direct competition for p300 binding at the promoter. Inflammation may influence the stem cell niche and tissue regeneration by influencing cellular responses to hypoxia.

  6. The role of phenoloxidase suppression in QX disease outbreaks among Sydney rock oysters

    E-Print Network [OSTI]

    Raftos, David

    disease. Oysters from the same brood stock were harvested from QX prone and QX free growing areas over negative correlation between phenoloxidase activity and the intensity of parasitic infection ( p = 0 prevented effective management of QX disease in endemic areas. Current management regimes rely only

  7. A Fault Tolerant 3-Phase Adjustable Speed Drive Topology with Common Mode Voltage Suppression

    E-Print Network [OSTI]

    Garg, Pawan

    2014-05-21T23:59:59.000Z

    ...................................................................................... 82 1 I INTRODUCTION I.1. Introduction Electric energy is a major source of energy all over the world. The estimated cumulative annual electric energy production of the world in 2011 was 22.126 TkW-hr [1]. This generation is projected... to increase up to 39 TkW-hr by 2040 [2]. According to International Energy Statistics, in 2011 United States domestic electricity consumption was 4.12 TkW-hr [1]. Out of this, in United States, about 38% of all electric energy is consumed by motor driven...

  8. Facilitating Memory for Novel Characters by Reducing Neural Repetition Suppression in the Left Fusiform Cortex

    E-Print Network [OSTI]

    Xue, Gui; Mei, Leilei; Chen, Chuansheng; Lu, Zhong-Lin; Poldrack, Russell A.; Dong, Qi

    2010-01-01T23:59:59.000Z

    deficits in developmental dyslexia? Brain 9. Shaywitz BA,children with developmental dyslexia. Biological Psychiatry2009) Children with dyslexia lack multiple specializations

  9. Coherent-feedback control strategy to suppress spontaneous switching in ultra-low power optical bistability

    E-Print Network [OSTI]

    Hideo Mabuchi

    2011-01-18T23:59:59.000Z

    An optical resonator with intracavity Kerr nonlinearity can exhibit dispersive bistability suitable for all-optical switching. With nanophotonic elements it may be possible to achieve attojoule switching energies, which would be very attractive for ultra-low power operation but potentially problematic because of quantum fluctuation-induced spontaneous switching. In this manuscript I derive a quantum-optical model of two Kerr-nonlinear ring resonators connected in a coherent feedback loop, and show via numerical simulation that a properly designed `controller' cavity can significantly reduce the spontaneous switching rate of a bistable `plant' cavity in a completely embedded and autonomous manner.

  10. RhoJ Regulates Melanoma Chemoresistance by Suppressing Pathways that Sense DNA Damage

    E-Print Network [OSTI]

    Ho, Hsiang; Aruri, Jayavani; Kapadia, Rubina; Mehr, Hootan; White, Michael A.; Ganesan, Anand K.

    2012-01-01T23:59:59.000Z

    Pathways that Sense DNA Damage $watermark-text Hsiang Ho 1 ,16. Roos WP, Kaina B. DNA damage-induced apoptosis: FromDNA lesions to the DNA damage response and apoptosis. Cancer

  11. Dust suppression characteristics of mineral oil when applied to corn, wheat, or soybeans

    E-Print Network [OSTI]

    Jones, David Don

    1986-01-01T23:59:59.000Z

    and must be added repeatedly. Several water applications could raise the mo i stu re content of grain to the point of encouraging mold growth. Peterson (1977) reported that an average worker wi 1 1 breathe from 4 to 10 m of air during an eight hour work... Jones, B. S. , Texas Al!M University Chairman of Advisory Committee: Dr. Calvin B. Parnell, Jr. Corn, wheat, and soybean samples weighing 454 g each were treated with mineral oil at rates of 50, 100, 200, 400, and 600 ppm and grain dust...

  12. An analog approach to interference suppression in ultra-wideband receivers

    E-Print Network [OSTI]

    Fischer, Timothy W.

    2007-09-17T23:59:59.000Z

    are presented, and a solution is proposed. To combat interference in Multi-Band OFDM (MB-OFDM) UWB systems, an analog notch filter is designed to be included in the UWB receive chain. The architecture of the filter is based on feed-forward subtraction...

  13. A systematic study of J/psi suppression in cold nuclear matter

    E-Print Network [OSTI]

    Arleo, Francois

    2008-01-01T23:59:59.000Z

    the better agreement when nuclear parton distributions aret o?ers the best agreement with the nuclear DIS and DY data.whose agreement with DIS and DY nuclear data is the best

  14. Chaos suppression in the parametrically driven Lorenz system Chol-Ung Choe,1,2

    E-Print Network [OSTI]

    : no measurements or extra sensors are re- quired. The idea of this method is to change the complex behavior is known for almost a century. As a textbook example, we men- tion the familiar stabilization of a reverse

  15. Influence of Transpiration Suppressants, Sprinkler Irrigation and Moisture Levels on Transpiration and Evapotranspiration

    E-Print Network [OSTI]

    Gerard, C. J.

    and reflective treatments increased the Ca content and lowered the K:Ca ratio of tomato fruits. Previous research has shown that these chemical properties are associated with lower plant water stress. The lower Ca content of citrus leaves and lower Brix¡ and acid...

  16. RhoJ Regulates Melanoma Chemoresistance by Suppressing Pathways that Sense DNA Damage

    E-Print Network [OSTI]

    Ho, Hsiang; Aruri, Jayavani; Kapadia, Rubina; Mehr, Hootan; White, Michael A.; Ganesan, Anand K.

    2012-01-01T23:59:59.000Z

    Lowe SW. Apoptosis and melanoma chemoresistance. Oncogene.reactivation therapy in melanoma. J Invest Dermatol. 2012;amplified in malignant melanoma. Nature. 2005; 436:117–

  17. Bacterial Effector HopF2 Suppresses Arabidopsis Immunity by Targeting BAK1

    E-Print Network [OSTI]

    Zhou, Jinggeng

    2013-07-19T23:59:59.000Z

    fluorescence protein GST glutathione-S-transferase HA hemagglutinin HrpZ harpin Z LPS lipopolysaccharide LRR leucine-rich repeat MAPK mitogen-activated protein kinase MKK5 MAPK kinase 5 NB-LRR nucleotide binding domain leucine-rich repeat NPP1 necrosis... ............................................................. 12 Plant materials and growth conditions ....................................................................... 12 Plasmid construction and generation of transgenic plants ......................................... 12 Pathogen assay...

  18. Observation of angle-modulated switch between enhancement and suppression of nonlinear

    E-Print Network [OSTI]

    Wu, Shin-Tson

    interaction of four-wave mixing image," Opt. Express 19(14), 13675­13685 (2011). 2. N. Li, Z. Zhao, H. Chen, P-Banacloche, "Measurement of dispersive properties of electromagnetically induced transparency in rubidium atoms," Phys. Rev. Li, L. M. Narducci, A. M. Lyyra, and F. C. Spano, "Autler-Townes splitting in molecular lithium

  19. Circuit for echo and noise suppression of acoustic signals transmitted through a drill string

    DOE Patents [OSTI]

    Drumheller, D.S.; Scott, D.D.

    1993-12-28T23:59:59.000Z

    An electronic circuit for digitally processing analog electrical signals produced by at least one acoustic transducer is presented. In a preferred embodiment of the present invention, a novel digital time delay circuit is utilized which employs an array of First-in-First-out (FiFo) microchips. Also, a bandpass filter is used at the input to this circuit for isolating drill string noise and eliminating high frequency output. 20 figures.

  20. Turbulence suppression in channel flows by small amplitude transverse wall oscillations

    E-Print Network [OSTI]

    Jovanovic, Mihailo

    and experimental investigations in channel,2­4 pipe,5­7 and boundary layer8­11 flows. In this paper, we model oscillatory wall motion or an oscillatory spanwise body force showed that a substantial drag reduction up

  1. In Vivo Identification of Tumor-Suppressive PTEN ceRNAs in an Oncogenic

    E-Print Network [OSTI]

    Bedwell, David M.

    by the frequent occurrence of acti- vating mutations in BRAF (Brose et al., 2002; Davies et al., 2002). Genetic

  2. The role of NK cells in selectin-dependent tumor suppression

    E-Print Network [OSTI]

    Sobolev, Olga, Ph. D. Massachusetts Institute of Technology

    2008-01-01T23:59:59.000Z

    Selectins are a small family of adhesion molecules that are critical for immune cell trafficking. In our laboratory, mice lacking all combinations of selectins have been generated. Previous work from our laboratory has ...

  3. Parasitic oscillation suppression in solid state lasers using absorbing thin films

    DOE Patents [OSTI]

    Zapata, L.E.

    1994-08-02T23:59:59.000Z

    A thin absorbing film is bonded onto at least certain surfaces of a solid state laser gain medium. An absorbing metal-dielectric multilayer film is optimized for a broad range of incidence angles, and is resistant to the corrosive/erosive effects of a coolant such as water, used in the forced convection cooling of the film. Parasitic oscillations hamper the operation of solid state lasers by causing the decay of stored energy to amplified rays trapped within the gain medium by total and partial internal reflections off the gain medium facets. Zigzag lasers intended for high average power operation require the ASE absorber. 16 figs.

  4. Parasitic oscillation suppression in solid state lasers using absorbing thin films

    DOE Patents [OSTI]

    Zapata, Luis E. (Livermore, CA)

    1994-01-01T23:59:59.000Z

    A thin absorbing film is bonded onto at least certain surfaces of a solid state laser gain medium. An absorbing metal-dielectric multilayer film is optimized for a broad range of incidence angles, and is resistant to the corrosive/erosive effects of a coolant such as water, used in the forced convection cooling of the film. Parasitic oscillations hamper the operation of solid state lasers by causing the decay of stored energy to amplified rays trapped within the gain medium by total and partial internal reflections off the gain medium facets. Zigzag lasers intended for high average power operation require the ASE absorber.

  5. First Observation of the Greisen-Zatsepin-Kuzmin Suppression R. U. Abbasi,1

    E-Print Network [OSTI]

    and Nevis Laboratory, Columbia University, New York, New York 10027, USA 4 Department of Physics, USA 2 Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA 3 Department of Physics and Astronomy, Rutgers University--The State University of New Jersey, Piscataway, New Jersey 08854, USA 5

  6. HE3286, an oral synthetic steroid, treats lung inflammation in mice without immune suppression

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    implications for therapy. Treat Respir Med 2004, 3:147-59.as a potential agent to treat autoimmune diseases. Autoimmunan oral synthetic steroid, treats lung inflammation in mice

  7. Automated suppression of errors in LTP-II slope measurements with x-ray optics

    E-Print Network [OSTI]

    Ali, Zulfiqar

    2012-01-01T23:59:59.000Z

    Helmholtz Zentrum Berlin (HZB)/BESSY-II (Germany) 4-7 and atan approach used with the HBZ/BESSY-II NOM instrument. 50 4.

  8. Automated suppression of errors in LTP-II slope measurements with x-ray optics

    E-Print Network [OSTI]

    Ali, Zulfiqar

    2012-01-01T23:59:59.000Z

    synchrotron facilities, such as the Nanometer Optical Component Measuring Machines (NOM) at Helmholtz Zentrum Berlin (HZB)/BESSY-

  9. Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State

    E-Print Network [OSTI]

    Garcia-Cao, Isabel

    Decremental loss of PTEN results in cancer susceptibility and tumor progression. PTEN elevation might therefore be an attractive option for cancer prevention and therapy. We have generated several transgenic mouse lines ...

  10. Extrinsic Cues Suppress the Encoding of Intrinsic Cues Bhavin R. Sheth1

    E-Print Network [OSTI]

    Crawford, Doug

    ), computational (Salinas & Abbott, 1995; Zipser & Andersen, 1988) and physiolog- ical (Batista, Buneo, Snyder

  11. PUBLICATIONS 1. "A Reexamination of the Subcarrier Demodulator Assembly Data Limiter Suppression Factor" (with L. Webster),

    E-Print Network [OSTI]

    Kuo, Lynn

    ", Proceedings, Section on Survey Research Methods, 1986, American Statistical Association, 460-465. 8. "Linear Research Methods, 1990, American Statistical Association, 314-319. 17. "A New Empirical Bayes Estimator Section, American Statistical Association, 165-170. 24. "Empirical Bayes Risk Evaluation with type II

  12. Techniques for noise suppression and robust control in spin-based quantum information processors

    E-Print Network [OSTI]

    Borneman, Troy William

    2013-01-01T23:59:59.000Z

    Processing information quantum mechanically allows the relatively efficient solution of many important problems thought to be intractable on a classical computer. A primary challenge in experimentally implementing a quantum ...

  13. The effect of an evaporation suppressant upon the liquid film oxygen transfer coefficient 

    E-Print Network [OSTI]

    Amad, Mohamad Towfic

    1967-01-01T23:59:59.000Z

    by organisms in a lake and the quantity of oxygen diffusion through the air-water interface were determined and the results were verified by field measurements. It was shown that the oxygen uptake rate of organisms in a body of water can be measured... diffusion. 3. To derive an expression to predict the minimum dissolved oxygen concentration during the critical night period for a lake o" pond treated with "Aquasave". The ~sco e of this research has been to determine the oxygen transfer coefficient...

  14. Interference characterization and suppression for multiuser direct-sequence spread-spectrum system

    E-Print Network [OSTI]

    Fan, Mingxi, 1975-

    2002-01-01T23:59:59.000Z

    In this thesis we investigate efficient modulation and detection techniques for the uplink (i.e. transmission from mobile to base station) of a DS-CDMA network. Specifically, the thesis contains three parts. In the first ...

  15. Improvement of extraction system geometry with suppression of possible Penning discharge ignition

    SciTech Connect (OSTI)

    Delferrière, O., E-mail: olivier.delferriere@cea.fr; Gobin, R.; Harrault, F.; Nyckees, S.; Tuske, O. [Commissariat à l’Energie Atomique et aux Energies Alternatives, CEA/Saclay, DSM/IRFU, 91191-Gif/Yvette (France)] [Commissariat à l’Energie Atomique et aux Energies Alternatives, CEA/Saclay, DSM/IRFU, 91191-Gif/Yvette (France)

    2014-02-15T23:59:59.000Z

    During the past two years, a new ECR 2.45 GHz type ion source has been developed especially dedicated to intense light ion injector project like IPHI (Injecteur Proton Haute Intensité), IFMIF (International Fusion Materials Irradiation Facility), to reduce beam emittance at RFQ entrance by shortening the length of the LEBT. This new ALISES concept (Advanced Light Ion Source Extraction System) is based on the use of an additional LEBT short length solenoid very close to the extraction aperture. The fringe field of this new solenoid produces the needed magnetic field to create the ECR resonance in the plasma chamber. Such geometry allows first putting the solenoid at ground potential, while saving space in front of the extraction to move the first LEBT solenoid closer and focus earlier the intense extracted beam. During the commissioning of the source in 2011–2012, ALISES has produced about 20 mA extracted from a 6 mm diameter plasma extraction hole at 23 kV. But the magnetic configuration combined to the new extraction system geometry led to important Penning discharge conditions in the accelerator column. Lots of them have been eliminated by inserting glass pieces between electrodes to modify equipotential lines with unfavorable ExB vacuum zones where particles were produced and trapped. To study Penning discharge location, several 3D calculations have been performed with OPERA-3D/TOSCA code to simulate the possible production and trapping of electrons in the extraction system. The results obtained on different sources already built have shown very good agreement with sparks location observed experimentally on electrodes. The simulations results as well as experimental measurements are presented and solutions to prevent possible Penning discharge in future source geometries are established.

  16. Suppressible pinning of Abrikosov vortices : effects of magnetic vortex arrays on thin superconducting films

    E-Print Network [OSTI]

    Smith, Kevin Daniel

    2008-01-01T23:59:59.000Z

    penetration through the superconductive film as it relatesThus, to sustain superconductivity throughout the materialthe mixed state, type-II superconductors have characteristic

  17. Regulatory T Cells Expanded from Hiv-1-Infected Individuals Maintain Phenotype, Tcr Repertoire and Suppressive Capacity

    E-Print Network [OSTI]

    Angin, Mathieu

    While modulation of regulatory T cell (Treg) function and adoptive Treg transfer are being explored as therapeutic modalities in the context of autoimmune diseases, transplantation and cancer, their role in HIV-1 pathogenesis ...

  18. Optimal suppression of defect generation during a passage across a quantum critical point

    E-Print Network [OSTI]

    Ning Wu; Arun Nanduri; Herschel Rabitz

    2014-12-09T23:59:59.000Z

    The dynamics of quantum phase transitions are inevitably accompanied by the formation of defects when crossing a quantum critical point. For a generic class of quantum critical systems, we solve the problem of minimizing the production of defects through the use of a gradient-based deterministic optimal control algorithm. By considering a finite size quantum Ising model with a tunable global transverse field, we show that an optimal power law quench of the transverse field across the Ising critical point works well at minimizing the number of defects, in spite of being drawn from a subset of quench profiles. These power law quenches are shown to be inherently robust against noise. The optimized defect density exhibits a transition at a critical ratio of the quench duration to the system size, which we argue coincides with the intrinsic speed limit for quantum evolution.

  19. Oxidative stress suppresses the cellular bioenergetic effect of the 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway

    SciTech Connect (OSTI)

    Módis, Katalin [Department of Anesthesiology, University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, TX (United States)] [Department of Anesthesiology, University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, TX (United States); Asimakopoulou, Antonia [Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, Patras (Greece)] [Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, Patras (Greece); Coletta, Ciro [Department of Anesthesiology, University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, TX (United States)] [Department of Anesthesiology, University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, TX (United States); Papapetropoulos, Andreas [Department of Anesthesiology, University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, TX (United States) [Department of Anesthesiology, University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, TX (United States); Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, Patras (Greece); Szabo, Csaba, E-mail: szabocsaba@aol.com [Department of Anesthesiology, University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, TX (United States)] [Department of Anesthesiology, University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, TX (United States)

    2013-04-19T23:59:59.000Z

    Highlights: •Oxidative stress impairs 3-MST-derived H{sub 2}S production in isolated enzyme and in isolated mitochondria. •This impairs the stimulatory bioenergetic effects of H{sub 2}S in hepatocytes. •This has implications for the pathophysiology of diseases with oxidative stress. -- Abstract: Recent data show that lower concentrations of hydrogen sulfide (H{sub 2}S), as well as endogenous, intramitochondrial production of H{sub 2}S by the 3-mercaptopyruvate (3-MP)/3-mercaptopyruvate sulfurtransferase (3-MST) pathway serves as an electron donor and inorganic source of energy to support mitochondrial electron transport and ATP generation in mammalian cells by donating electrons to Complex II. The aim of our study was to investigate the role of oxidative stress on the activity of the 3-MP/3-MST/H{sub 2}S pathway in vitro. Hydrogen peroxide (H{sub 2}O{sub 2}, 100–500 ?M) caused a concentration-dependent decrease in the activity of recombinant mouse 3-MST enzyme. In mitochondria isolated from murine hepatoma cells, H{sub 2}O{sub 2} (50–500 ?M) caused a concentration-dependent decrease in production of H{sub 2}S from 3-MP. In cultured murine hepatoma cells H{sub 2}O{sub 2}, (3–100 ?M), did not result in overall cytotoxicity, but caused a partial decrease in basal oxygen consumption and respiratory reserve rapacity. The positive bioenergetic effect of 3-MP (100–300 nM) was completely abolished by pre-treatment of the cells with H{sub 2}O{sub 2} (50 ?M). The current findings demonstrate that oxidative stress inhibits 3-MST activity and interferes with the positive bioenergetic role of the 3-MP/3-MST/H{sub 2}S pathway. These findings may have implications for the pathophysiology of various conditions associated with increased oxidative stress, such as various forms of critical illness, cardiovascular diseases, diabetes or physiological aging.

  20. Suppression of Mode-Beating in a Saturated Hole-Coupling FEL Oscillator

    E-Print Network [OSTI]

    Krishnagopal, S.

    2011-01-01T23:59:59.000Z

    cavity case L and with an FEL interaction. of mode-beatingMode profiles (with an FEL interaction) at three differentin a Saturated Hole-coupled FEL Oscillator S. Krishnagopal,