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  1. Compound and Elemental Analysis At Seven Mile Hole Area (Larson...

    Open Energy Info (EERE)

    Seven Mile Hole Area (Larson, Et Al., 2009) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Compound and Elemental Analysis At Seven Mile Hole...

  2. Rock Sampling At Seven Mile Hole Area (Larson, Et Al., 2009)...

    Open Energy Info (EERE)

    Seven Mile Hole Area (Larson, Et Al., 2009) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Rock Sampling At Seven Mile Hole Area (Larson, Et...

  3. Isotopic Analysis At Seven Mile Hole Area (Larson, Et Al., 2009...

    Open Energy Info (EERE)

    Seven Mile Hole Area (Larson, Et Al., 2009) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Isotopic Analysis At Seven Mile Hole Area (Larson, Et...

  4. Field Mapping At Seven Mile Hole Area (Larson, Et Al., 2009)...

    Open Energy Info (EERE)

    Seven Mile Hole Area (Larson, Et Al., 2009) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Field Mapping At Seven Mile Hole Area (Larson, Et...

  5. Analysis of soil and water at the Four Mile Creek seepline near the F- and H-Areas of SRS

    SciTech Connect (OSTI)

    Haselow, J.S.

    2000-05-24

    Several soil and water samples were collected along the Four Mile Creek (FMC) seepline at the F and H Areas of the Savannah River Site. The samples were analyzed for concentrations of metals, radionuclides, and inorganic constituents. The results of the analyses are summarized for the soil and water samples.

  6. Effects of outcropping groundwater from the F- and H-Area seepage basins on the distribution of fish in Four Mile Creek

    SciTech Connect (OSTI)

    Paller, M.H.; Storey, C.

    1990-10-01

    Four Mile Creek was electrofished during June 26--July 2, 1990 to assess the impacts of outcropping ground water form the F- and H-Area Seepage Basins on fish abundance and distribution. Number of fish species and total catch were comparable at sample stations upstream from and downstream from the outcropping zone in Four Mile Creek. Species number and composition downstream from the outcropping zone in Four Mile Creek were similar to species number and composition in unimpacted portions of Pen Branch, Steel Creek, and Meyers Branch. These findings indicate that seepage basin outcropping was not adversely affecting the Four Mile Creek fish community. 5 refs., 3 figs., 4 tabs.

  7. Cancer incidence among residents of the Three Mile Island accident area: 1982-1995

    SciTech Connect (OSTI)

    Han, Yueh-Ying; Youk, Ada O.; Sasser, Howell; Talbott, Evelyn O.

    2011-11-15

    Background: The Pennsylvania Department of Health established a registry of the Three Mile Island (TMI) nuclear power plant accident in 1979. Over 93% of the population present on the day of the accident within a 5-mile radius was enrolled and interviewed. We used the registry to investigate the potential cancer risk from low-dose radiation exposure among the TMI population. Methods: Cancer incidence data among the TMI cohort were available from 1982 to 1995. Because more than 97% of the population were white and few cancer cases were reported for those younger than 18 years of age, we included whites of age 18 years and older (10,446 men and 11,048 women) for further analyses. Cox regression models were used to estimate the relative risk (RR) per 0.1 m Sv and 95% confident interval (CI) of cancer by radiation-related exposures. The cancers of interest were all malignant neoplasms, cancer of bronchus, trachea, and lung, cancer of lymphatic and hematopoietic tissues, leukemia, and female breast. Results: Among men and women, there was no evidence of an increased risk for all malignant neoplasms among the TMI cohort exposed to higher maximum and likely {gamma} radiation (RR=1.00, 95% CI=0.97, 1.01 and RR=0.99, 95% CI=0.94, 1.03, respectively) after adjusting for age, gender, education, smoking, and background radiation. Elevation in risk was noted for cancer of the bronchus, trachea, and lung in relation to higher background radiation exposure (RR=1.45, 95% CI=1.02-2.05 at 8.0-8.8 {mu}R/h compared to 5.2-7.2 {mu}R/h). An increased risk of leukemia was found among men exposed to higher maximum and likely {gamma} radiation related to TMI exposure during the ten days following the accident (RR=1.15, 95% CI=1.04, 1.29 and RR=1.36, 95% CI=1.08, 1.71, respectively). This relationship was not found in women. Conclusion: Increased cancer risks from low-level radiation exposure within the TMI cohort were small and mostly statistically non-significant. However, additional

  8. Miles Hall

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Miles Hall - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery Testing Nuclear Energy Defense Waste Management Programs Advanced Nuclear Energy

  9. Miles Hand Grenade

    DOE Patents [OSTI]

    Harrington, John J.; Buttz, James H.; Maish, Alex B.; Page, Ray R.; Metcalf, Herbert E.

    2005-11-15

    A simulated grenade for MILES-type simulations generates a unique RF signal and a unique audio signal. A detector utilizes the time between receipt of the RF signal and the slower-traveling audio signal to determine the distance between the detector and the simulated grenade.

  10. miles-99.PDF

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Vertical Velocity Statistics as Derived from 94-GHz Radar Measurements N. L. Miles, D. M. Babb, and J. Verlinde The Pennsylvania State University University Park, Pennsylvania Introduction Profiles of millimeter-wavelength radar Doppler spectra contain information about both the mean vertical velocities and cloud microphysics. In order to obtain this information, it is necessary to remove the effects of turbulence. Stratocumulus clouds often contain various species of ice and liquid, including

  11. DOE - Office of Legacy Management -- Carboloy Co - MI 12

    Office of Legacy Management (LM)

    Carboloy Co - MI 12 FUSRAP Considered Sites Site: Carboloy Co. (MI.12 ) Eliminated from further consideration under FUSRAP - AEC licensed facility Designated Name: Not Designated Alternate Name: General Electric MI.12-1 Location: 11177 E. Eight Mile Road , Detroit , Michigan MI.12-1 MI.12-2 Evaluation Year: 1987-1991 MI.12-3 MI.12-4 MI.12-6 Site Operations: Turned-down the outer diameter of uranium metal slugs and conducted pilot plant scale operations for hot pressing uranium dioxide pellets

  12. Chapter 3. Vehicle-Miles Traveled

    U.S. Energy Information Administration (EIA) Indexed Site

    3. Vehicle-Miles Traveled Chapter 3. Vehicle-Miles Traveled Vehicle-miles traveled--the number of miles that residential vehicles are driven--is probably the most important...

  13. The Three Mile Island crisis

    SciTech Connect (OSTI)

    Houts, P.S.; Cleary, P.D.; Hu, T.W.

    1988-01-01

    Since the March 1979 accident at the Three Mile Island (TMI) nuclear power plant, many studies have assessed its impacts. Compiled and summarized in this book are the results of five related surveys, all aimed at the scientific assessment of the psycho-socio-economic behavior of the residents around the TMI facility. These studies are based on a randomly selected, large sample of the population (with telephones) around TMI.

  14. Approach to Recover Hydrocarbons from Currently Off-Limit Areas of the Antrim Formation, MI Using Low-Impact Technologies

    SciTech Connect (OSTI)

    James Wood; William Quinlan

    2008-09-30

    The goal of this project was to develop and execute a novel drilling and completion program in the Antrim Shale near the western shoreline of Northern Michigan. The target was the gas in the Lower Antrim Formation (Upper Devonian). Another goal was to see if drilling permits could be obtained from the Michigan DNR that would allow exploitation of reserves currently off-limits to exploration. This project met both of these goals: the DNR (Michigan Department of Natural Resources) issued permits that allow drilling the shallow subsurface for exploration and production. This project obtained drilling permits for the original demonstration well AG-A-MING 4-12 HD (API: 21-009-58153-0000) and AG-A-MING 4-12 HD1 (API: 21-009-58153-0100) as well as for similar Antrim wells in Benzie County, MI, the Colfax 3-28 HD and nearby Colfax 2-28 HD which were substituted for the AG-A-MING well. This project also developed successful techniques and strategies for producing the shallow gas. In addition to the project demonstration well over 20 wells have been drilled to date into the shallow Antrim as a result of this project's findings. Further, fracture stimulation has proven to be a vital step in improving the deliverability of wells to deem them commercial. Our initial plan was very simple; the 'J-well' design. We proposed to drill a vertical or slant well 30.48 meters (100 feet) below the glacial drift, set required casing, then angle back up to tap the resource lying between the base to the drift and the conventional vertical well. The 'J'-well design was tested at Mancelona Township in Antrim County in February of 2007 with the St. Mancelona 2-12 HD 3.

  15. Miles Electric Vehicles | Open Energy Information

    Open Energy Info (EERE)

    Electric Vehicles Jump to: navigation, search Name: Miles Electric Vehicles Place: Santa Monica, California Zip: 90405 Sector: Vehicles Product: California-based developer of...

  16. Mile High: Order (2012-SE-4501)

    Broader source: Energy.gov [DOE]

    DOE ordered Mile High Equipment, LLC to pay a $17,525 civil penalty after finding Mile High had manufactured and distributed in commerce in the U.S. approximately 109 units of lce-O-Matic brand automatic commercial ice maker basic model ICE2106 FW, HW, a noncompliant product.

  17. Mile High: Proposed Penalty (2012-SE-4501)

    Broader source: Energy.gov [DOE]

    DOE alleged in a Notice of Proposed Civil Penalty that Mile High Equipment, LLC manufactured and distributed noncompliant Ice-O-Matic brand automatic commercial ice maker basic model ICE2106 FW, HW in the U.S.

  18. Mile High: Noncompliance Determination (2012-SE-4501)

    Broader source: Energy.gov [DOE]

    DOE issued a Notice of Noncompliance Determination to Mile High Equipment, LLC finding that Ice-O-Matic brand automatic commercial ice maker basic model ICE2106 FW, HW does not comport with the energy conservation standards.

  19. DOE - Office of Legacy Management -- General Motors Co - Flint - MI 07

    Office of Legacy Management (LM)

    Motors Co - Flint - MI 07 FUSRAP Considered Sites Site: GENERAL MOTORS CO. (MI.07 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: A.C. Spark Plug Dort Highway Plant MI.07-1 MI.07-2 Location: Flint , Michigan MI.07-1 Evaluation Year: 1987 MI.07-3 Site Operations: Processed thorium oxide, uranium oxide, and beryllium oxide into crucibles for the Chicago Area. MI.07-3 MI.07-4 MI.07-5 Site Disposition: Eliminated - Potential for contamination

  20. March 28, 1979: Three Mile Island | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    8, 1979: Three Mile Island March 28, 1979: Three Mile Island March 28, 1979: Three Mile Island March 28, 1979 A partial meltdown of the core occurs at one of the two reactors at the Three Mile Island nuclear power plant near Harrisburg, Pennsylvania

  1. Alternative Fuels Data Center: Oregon Celebrates 200 Miles of Electric

    Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

    Highways Oregon Celebrates 200 Miles of Electric Highways to someone by E-mail Share Alternative Fuels Data Center: Oregon Celebrates 200 Miles of Electric Highways on Facebook Tweet about Alternative Fuels Data Center: Oregon Celebrates 200 Miles of Electric Highways on Twitter Bookmark Alternative Fuels Data Center: Oregon Celebrates 200 Miles of Electric Highways on Google Bookmark Alternative Fuels Data Center: Oregon Celebrates 200 Miles of Electric Highways on Delicious Rank

  2. Pennsylvania Nuclear Profile - Three Mile Island

    U.S. Energy Information Administration (EIA) Indexed Site

    Three Mile Island" "Unit","Summer capacity (mw)","Net generation (thousand mwh)","Summer capacity factor (percent)","Type","Commercial operation date","License expiration date" 1,805,"6,634",94.1,"PWR","application/vnd.ms-excel","application/vnd.ms-excel" ,805,"6,634",94.1

  3. Seven Mile Hole Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    and Environmental Issues Click "Edit With Form" above to add content Exploration History First Discovery Well Completion Date: Well Name: Location: Depth: Initial Flow...

  4. Seven Mile Hole Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    GEA Development Phase: Resource Estimate Mean Reservoir Temp: Estimated Reservoir Volume: Mean Capacity: USGS Mean Reservoir Temp: USGS Estimated Reservoir Volume: USGS Mean...

  5. Salt Wells, Eight Mile Flat | Open Energy Information

    Open Energy Info (EERE)

    Eight Mile Flat Jump to: navigation, search OpenEI Reference LibraryAdd to library Web Site: Salt Wells, Eight Mile Flat Abstract Abstract unavailable. Author Nevada Bureau...

  6. Focus Series: Denver Energy Advisor Program Helps Homeowners Go the Extra Mile in Mile-High City

    Office of Energy Efficiency and Renewable Energy (EERE)

    Focus Series: Denver Energy Advisor Program Helps Homeowners Go the Extra Mile in Mile-High City, a publication of the U.S. Department of Energy's Better Buildings Program.

  7. Measurement of the direct <mi>CP> -violating parameter <mi>Ami><mi>CP> in the decay <mi>D>+<mi>Kmi>-<mimi>+<mi>π>+

    SciTech Connect (OSTI)

    Abazov, V. M.; Abbott, B.; Acharya, B. S.; Adams, M.; Adams, T.; Agnew, J. P.; Alexeev, G. D.; Alkhazov, G.; Alton, A.; Askew, A.; Atkins, S.; Augsten, K.; Avila, C.; Badaud, F.; Bagby, L.; Baldin, B.; Bandurin, D. V.; Banerjee, S.; Barberis, E.; Baringer, P.; Bartlett, J. F.; Bassler, U.; Bazterra, V.; Bean, A.; Begalli, M.; Bellantoni, L.; Beri, S. B.; Bernardi, G.; Bernhard, R.; Bertram, I.; Besançon, M.; Beuselinck, R.; Bhat, P. C.; Bhatia, S.; Bhatnagar, V.; Blazey, G.; Blessing, S.; Bloom, K.; Boehnlein, A.; Boline, D.; Boos, E. E.; Borissov, G.; Borysova, M.; Brandt, A.; Brandt, O.; Brock, R.; Bross, A.; Brown, D.; Bu, X. B.; Buehler, M.; Buescher, V.; Bunichev, V.; Burdin, S.; Buszello, C. P.; Camacho-Pérez, E.; Casey, B. C. K.; Castilla-Valdez, H.; Caughron, S.; Chakrabarti, S.; Chan, K. M.; Chandra, A.; Chapon, E.; Chen, G.; Cho, S. W.; Choi, S.; Choudhary, B.; Cihangir, S.; Claes, D.; Clutter, J.; Cooke, M.; Cooper, W. E.; Corcoran, M.; Couderc, F.; Cousinou, M. -C.; Cutts, D.; Das, A.; Davies, G.; de Jong, S. J.; De La Cruz-Burelo, E.; Déliot, F.; Demina, R.; Denisov, D.; Denisov, S. P.; Desai, S.; Deterre, C.; DeVaughan, K.; Diehl, H. T.; Diesburg, M.; Ding, P. F.; Dominguez, A.; Dubey, A.; Dudko, L. V.; Duperrin, A.; Dutt, S.; Eads, M.; Edmunds, D.; Ellison, J.; Elvira, V. D.; Enari, Y.; Evans, H.; Evdokimov, V. N.; Fauré, A.; Feng, L.; Ferbel, T.; Fiedler, F.; Filthaut, F.; Fisher, W.; Fisk, H. E.; Fortner, M.; Fox, H.; Fuess, S.; Garbincius, P. H.; Garcia-Bellido, A.; García-González, J. A.; Gavrilov, V.; Geng, W.; Gerber, C. E.; Gershtein, Y.; Ginther, G.; Gogota, O.; Golovanov, G.; Grannis, P. D.; Greder, S.; Greenlee, H.; Grenier, G.; Gris, Ph.; Grivaz, J. -F.; Grohsjean, A.; Grünendahl, S.; Grünewald, M. W.; Guillemin, T.; Gutierrez, G.; Gutierrez, P.; Haley, J.; Han, L.; Harder, K.; Harel, A.; Hauptman, J. M.; Hays, J.; Head, T.; Hebbeker, T.; Hedin, D.; Hegab, H.; Heinson, A. P.; Heintz, U.; Hensel, C.; Heredia-De La Cruz, I.; Herner, K.; Hesketh, G.; Hildreth, M. D.; Hirosky, R.; Hoang, T.; Hobbs, J. D.; Hoeneisen, B.; Hogan, J.; Hohlfeld, M.; Holzbauer, J. L.; Howley, I.; Hubacek, Z.; Hynek, V.; Iashvili, I.; Ilchenko, Y.; Illingworth, R.; Ito, A. S.; Jabeen, S.; Jaffré, M.; Jayasinghe, A.; Jeong, M. S.; Jesik, R.; Jiang, P.; Johns, K.; Johnson, E.; Johnson, M.; Jonckheere, A.; Jonsson, P.; Joshi, J.; Jung, A. W.; Juste, A.; Kajfasz, E.; Karmanov, D.; Katsanos, I.; Kaur, M.; Kehoe, R.; Kermiche, S.; Khalatyan, N.; Khanov, A.; Kharchilava, A.; Kharzheev, Y. N.; Kiselevich, I.; Kohli, J. M.; Kozelov, A. V.; Kraus, J.; Kumar, A.; Kupco, A.; Kurča, T.; Kuzmin, V. A.; Lammers, S.; Lebrun, P.; Lee, H. S.; Lee, S. W.; Lee, W. M.; Lei, X.; Lellouch, J.; Li, D.; Li, H.; Li, L.; Li, Q. Z.; Lim, J. K.; Lincoln, D.; Linnemann, J.; Lipaev, V. V.; Lipton, R.; Liu, H.; Liu, Y.; Lobodenko, A.; Lokajicek, M.; Lopes de Sa, R.; Luna-Garcia, R.; Lyon, A. L.; Maciel, A. K. A.; Madar, R.; Magaña-Villalba, R.; Malik, S.; Malyshev, V. L.; Mansour, J.; Martínez-Ortega, J.; McCarthy, R.; McGivern, C. L.; Meijer, M. M.; Melnitchouk, A.; Menezes, D.; Mercadante, P. G.; Merkin, M.; Meyer, A.; Meyer, J.; Miconi, F.; Mondal, N. K.; Mulhearn, M.; Nagy, E.; Narain, M.; Nayyar, R.; Neal, H. A.; Negret, J. P.; Neustroev, P.; Nguyen, H. T.; Nunnemann, T.; Orduna, J.; Osman, N.; Osta, J.; Pal, A.; Parashar, N.; Parihar, V.; Park, S. K.; Partridge, R.; Parua, N.; Patwa, A.; Penning, B.; Perfilov, M.; Peters, Y.; Petridis, K.; Petrillo, G.; Pétroff, P.; Pleier, M. -A.; Podstavkov, V. M.; Popov, A. V.; Prewitt, M.; Price, D.; Prokopenko, N.; Qian, J.; Quadt, A.; Quinn, B.; Ratoff, P. N.; Razumov, I.; Ripp-Baudot, I.; Rizatdinova, F.; Rominsky, M.; Ross, A.; Royon, C.; Rubinov, P.; Ruchti, R.; Sajot, G.; Sánchez-Hernández, A.; Sanders, M. P.; Santos, A. S.; Savage, G.; Savitskyi, M.; Sawyer, L.; Scanlon, T.; Schamberger, R. D.; Scheglov, Y.; Schellman, H.; Schwanenberger, C.; Schwienhorst, R.; Sekaric, J.; Severini, H.; Shabalina, E.; Shary, V.; Shaw, S.; Shchukin, A. A.; Simak, V.; Skubic, P.; Slattery, P.; Smirnov, D.; Snow, G. R.; Snow, J.; Snyder, S.; Söldner-Rembold, S.; Sonnenschein, L.; Soustruznik, K.; Stark, J.; Stoyanova, D. A.; Strauss, M.; Suter, L.; Svoisky, P.; Titov, M.; Tokmenin, V. V.; Tsai, Y. -T.; Tsybychev, D.; Tuchming, B.; Tully, C.; Uvarov, L.; Uvarov, S.; Uzunyan, S.; Van Kooten, R.; van Leeuwen, W. M.; Varelas, N.; Varnes, E. W.; Vasilyev, I. A.; Verkheev, A. Y.; Vertogradov, L. S.; Verzocchi, M.; Vesterinen, M.; Vilanova, D.; Vokac, P.; Wahl, H. D.; Wang, M. H. L. S.; Warchol, J.; Watts, G.; Wayne, M.; Weichert, J.; Welty-Rieger, L.; Williams, M. R. J.; Wilson, G. W.; Wobisch, M.; Wood, D. R.; Wyatt, T. R.; Xie, Y.; Yamada, R.; Yang, S.; Yasuda, T.; Yatsunenko, Y. A.; Ye, W.; Ye, Z.; Yin, H.; Yip, K.; Youn, S. W.; Yu, J. M.; Zennamo, J.; Zhao, T. G.; Zhou, B.; Zhu, J.; Zielinski, M.; Zieminska, D.; Zivkovic, L.

    2014-12-01

    We measure the direct mi>Cmi>mi>P>-violating parameter mi>Ami>mi>Cmi>mi>Pmi> for the decay of the charged charm meson, mi>Dmi>+mi>Kmi>-mi>πmi>+mi>πmi>+ (and charge conjugate), using the full 10.4 mi>fbmi>-1 sample of mi>p>mi>p>¯ collisions at mi>smi>=1.96 mi>TeVmi> collected by the D0 detector at the Fermilab Tevatron collider. We extract the raw reconstructed charge asymmetry by fitting the invariant mass distributions for the sum and difference of charge-specific samples. This quantity is then corrected for detector-related asymmetries using data-driven methods and for possible physics asymmetries (from mi>B>mi>D

  8. Vegetation survey of Pen Branch and Four Mile Creek wetlands

    SciTech Connect (OSTI)

    Not Available

    1992-01-01

    One hundred-fifty plots were recently sampled (vegetational sampling study) at the Savannah River Site (SRS). An extensive characterization of the vascular flora, in four predetermined strata (overstory, Understory, shrub layer, and ground cover), was undertaken to determine dominance, co-dominance, and the importance value (I.V.) of each species. These results will be used by the Savannah River Laboratory (SRL) to evaluate the environmental status of Four Mile Creek, Pen Branch, and two upland pine stands. Objectives of this study were to: Describe in detail the plant communities previously mapped with reference to the topography and drainage, including species of plants present: Examine the successional trends within each sampling area and describe the extent to which current vegetation communities have resulted from specific earlier vegetation disturbances (e.g., logging and grazing); describe in detail the botanical field techniques used to sample the flora; describe the habitat and location of protected and/or rare species of plants; and collect and prepare plant species as herbarium quality specimens. Sampling was conducted at Four Mile Creek and Pen Branch, and in two upland pine plantations of different age growth.

  9. Vegetation survey of Pen Branch and Four Mile Creek wetlands

    SciTech Connect (OSTI)

    Not Available

    1992-10-01

    One hundred-fifty plots were recently sampled (vegetational sampling study) at the Savannah River Site (SRS). An extensive characterization of the vascular flora, in four predetermined strata (overstory, Understory, shrub layer, and ground cover), was undertaken to determine dominance, co-dominance, and the importance value (I.V.) of each species. These results will be used by the Savannah River Laboratory (SRL) to evaluate the environmental status of Four Mile Creek, Pen Branch, and two upland pine stands. Objectives of this study were to: Describe in detail the plant communities previously mapped with reference to the topography and drainage, including species of plants present: Examine the successional trends within each sampling area and describe the extent to which current vegetation communities have resulted from specific earlier vegetation disturbances (e.g., logging and grazing); describe in detail the botanical field techniques used to sample the flora; describe the habitat and location of protected and/or rare species of plants; and collect and prepare plant species as herbarium quality specimens. Sampling was conducted at Four Mile Creek and Pen Branch, and in two upland pine plantations of different age growth.

  10. Entiat 4Mile WELLs Completion Report, 2006.

    SciTech Connect (OSTI)

    Malinowksi, Richard

    2007-01-01

    The Entiat 4-mile Wells (Entiat 4-mile) project is located in the Entiat subbasin and will benefit Upper Columbia steelhead, spring Chinook and bull trout. The goal of this project is to prevent juvenile fish from being diverted into an out-of-stream irrigation system and to eliminate impacts due to the annual maintenance of an instream pushup dam. The objectives include eliminating a surface irrigation diversion and replacing it with two wells, which will provide Bonneville Power Administration (BPA) and the Bureau of Reclamation (Reclamation) with a Federal Columbia River Power System (FCRPS) BiOp metric credit of one. Wells were chosen over a new fish screen based on biological benefits and costs. Long-term biological benefits are provided by completely eliminating the surface diversion and the potential for fish entrainment in a fish screen. Construction costs for a new fish screen were estimated at $150,000, which does not include other costs associated with implementing and maintaining a fish screening project. Construction costs for a well were estimated at $20,000 each. The diversion consisted of a pushup dam that diverted water into an off-channel pond. Water was then pumped into a pressurized system for irrigation. There are 3 different irrigators who used water from this surface diversion, and each has multiple water right claims totaling approximately 5 cfs. Current use was estimated at 300 gallons per minute (approximately 0.641 cfs). Some irrigated acreage was taken out of orchard production less than 5 years ago. Therefore, approximately 6.8 acre-feet will be put into the State of Washington Trust Water Right program. No water will be set aside for conservation savings. The construction of the two irrigation wells for three landowners was completed in September 2006. The Lower Well (Tippen/Wick) will produce up to 175 gpm while the Upper Well (Griffith) will produce up to 275 gpm during the irrigation season. The eight inch diameter wells were

  11. Petroleum Reduction Strategies to Reduce Vehicle Miles Traveled

    Broader source: Energy.gov [DOE]

    For reducing greenhouse gas emissions, the table below describes petroleum reduction strategies to reduce vehicle miles traveled, as well as guidance and best practices for each strategy.

  12. Fact #860 February 16, 2015 Relationship of Vehicle Miles of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Excel file and dataset for Relationship of Vehicle Miles of Travel and the Price of ... Move in Opposition - Dataset 2012 Data File 2013 Wind Technologies Market Report Data

  13. Seven Mile Hill Wind Farm | Open Energy Information

    Open Energy Info (EERE)

    www.wsgs.uwyo.eduTopicsEnergyResourceswind.aspx http:renewableenergydev.comredwind-power-seven-mile-hill-wind-energy-project Retrieved from "http:en.openei.orgw...

  14. Title list publicly available documents: Three Mile Island Unit...

    Office of Scientific and Technical Information (OSTI)

    Subject: 21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS THREE MILE ISLAND-2 REACTOR; BIBLIOGRAPHIES; REACTOR LICENSING; DC - 78 - Light Water Reactor Technology Word Cloud More ...

  15. EIS-0025: Miles City-New Underwood 230-kV Electrical Transmission Line, Montana, North Dakota, and South Dakota

    Broader source: Energy.gov [DOE]

    The U.S. Department of Energy’s Western Area Power Administration prepared this statement to assess the environmental and socioeconomic implications of its proposed action to construct a 3.28-mile, 230-kV transmission line between Miles City and Baker, Montana, Hettinger, North Dakota, and New Underwood, South Dakota, in Custer and Fallon Counties in Montana, Adams, Bowman, and Slope Counties in North Dakota and Meade, Pennington, and Perkins Counties in South Dakota.

  16. MINOS Experiment and NuMI Beam Home Page

    Broader source: All U.S. Department of Energy (DOE) Office Webpages

    NuMI-MINOS Neutrino Logo NuMI Beamline and MINOS Experiment Neutrino Logo The MINOS Experiment and NuMI Beamline Fermilab Logo MINOS Experiment Links ◊ MINOS for the Public ◊ Scientific Results ◊ MINOS at Work ◊ NuMI at Work ◊ MINOS+ Experiment Fermilab Neutrino Links ◊ Neutrino FAQ ◊ MINOS Underground Areas at Fermilab ◊ PPD Intensity Frontier Dept Back to - - - ◊ Fermilab at Work ◊ Fermilab Home the MINOS Far Detector in the Soudan Mine MINOS collaborators assembling the

  17. Vehicle Technologies Office Merit Review 2015: Electric Vehicle Mile

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Traveled (eVMT): On-road Results and Analysis | Department of Energy Electric Vehicle Mile Traveled (eVMT): On-road Results and Analysis Vehicle Technologies Office Merit Review 2015: Electric Vehicle Mile Traveled (eVMT): On-road Results and Analysis Presentation given by Idaho National Laboratory at 2015 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Office Annual Merit Review and Peer Evaluation meeting about Electric Vehicle Mile Traveled (eVMT): on-road results and

  18. Seven Mile, Ohio: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    article is a stub. You can help OpenEI by expanding it. Seven Mile is a village in Butler County, Ohio. It falls under Ohio's 8th congressional district.12 References ...

  19. "Table 11. Fuel Economy, Selected Survey Years (Miles Per Gallon...

    U.S. Energy Information Administration (EIA) Indexed Site

    Fuel Economy, Selected Survey Years (Miles Per Gallon)" ,"Survey Years" ,1983,1985,1988,1991,1994,2001 "Total",15.1,16.1,18.3,19.3,19.8,20.2 "Household Characteristics" "Census...

  20. China has 6,000-mile pipeline system

    SciTech Connect (OSTI)

    Ming, S.

    1983-08-01

    A dramatic change has taken place in China's oil transport system, with pipelines replacing tank-cars as the most important means of transport for crude oil and petroleum products. According to Petroleum Ministry officials, the volume of crude oil carried by China's pipeline system increased from 23.2 percent in 1971 to 65.6 percent in 1981, while the volume delivered by tank-cars declined from 61.11 percent to 8.4 percent. The remainder was transported by tankers. China's 9,700 km (6,000-mile) pipeline network includes 5,600 km (3,500 miles) designed to carry crude oil and more than 600 km (375 miles) for petroleum products, plus 3,400 km (2,100 miles), mostly in Sichuan province, for natural gas.

  1. Microsoft Word - 10_Million_Loaded_Miles.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    WIPP Trucks Surpass 10 Million Loaded Miles CARLSBAD, N.M., April 19, 2010 - The U.S. Department of Energy's (DOE) Carlsbad Field Office said drivers, who haul defense-related transuranic (TRU) waste to the Waste Isolation Pilot Plant, surpassed 10 million safe, loaded miles. The first of more than 8,400 shipments to WIPP arrived 11 years ago from Los Alamos National Laboratory in northern New Mexico. "There's no doubt, some of the best drivers in the transportation industry work for

  2. New York Nuclear Profile - Nine Mile Point Nuclear Station

    U.S. Energy Information Administration (EIA) Indexed Site

    Nine Mile Point Nuclear Station" "Unit","Summer capacity (mw)","Net generation (thousand mwh)","Summer capacity factor (percent)","Type","Commercial operation date","License expiration date" 1,630,"5,294",95.9,"BWR","application/vnd.ms-excel","application/vnd.ms-excel"

  3. Lessons Learned from Three Mile Island Packaging, Transportation and Disposition that Apply to Fukushima Daiichi Recovery

    SciTech Connect (OSTI)

    Layne Pincock; Wendell Hintze; Dr. Koji Shirai

    2012-07-01

    Following the massive earthquake and resulting tsunami damage in March of 2011 at the Fukushima Daiichi nuclear power plant in Japan, interest was amplified for what was done for recovery at the Three Mile Island Unit 2 (TMI-2) in the United States following its meltdown in 1979. Many parallels could be drawn between to two accidents. This paper presents the results of research done into the TMI-2 recovery effort and its applicability to the Fukushima Daiichi cleanup. This research focused on three topics: packaging, transportation, and disposition. This research work was performed as a collaboration between Japan’s Central Research Institute of Electric Power Industry (CRIEPI) and the Idaho National Laboratory (INL). Hundreds of TMI-2 related documents were searched and pertinent information was gleaned from these documents. Other important information was also obtained by interviewing employees who were involved first hand in various aspects of the TMI-2 cleanup effort. This paper is organized into three main sections: (1) Transport from Three Mile Island to Central Facilities Area at INL, (2) Transport from INL Central Receiving Facility to INL Test Area North (TAN) and wet storage at TAN, and (3) Transport from TAN to INL Idaho Nuclear Technology and Engineering Center (INTEC) and Dry Storage at INTEC. Within each of these sections, lessons learned from performing recovery activities are presented and their applicability to the Fukushima Daiichi nuclear power plant cleanup are outlined.

  4. Early dismantlement of Three Mile Island Unit 2

    SciTech Connect (OSTI)

    Byrne, J.; Heisey, K.A.

    1996-12-31

    Three Mile Island Unit 2 (TMI-2) nuclear station ceased commercial operation following the March 1979 accident. Following completion of an extensive cleanup effort that included removal and shipment of the damaged core, the U.S. Nuclear Regulatory Commission issued a possession-only license (POL) amendment on September 14, 1993. Postdefueling monitored storage (PDMS) technical specifications were issued on December 28, 1993. Entry into PDMS required that the licensee demonstrate that the plant was in a safe and stable condition and posed no risk to public health and safety.

  5. Analysis of Three Mile Island-Unit 2 accident

    SciTech Connect (OSTI)

    Not Available

    1980-03-01

    The Nuclear Safety Analysis Center (NSAC) of the Electric Power Research Institute has analyzed the Three Mile Island-2 accident. Early results of this analysis were a brief narrative summary, issued in mid-May 1979 and an initial version of this report issued later in 1979 as noted in the Foreword. The present report is a revised version of the 1979 report, containing summaries, a highly detailed sequence of events, a comparison of that sequence of events with those from other sources, 25 appendices, references and a list of abbreviations and acronyms. A matrix of equipment and system actions is included as a folded insert.

  6. Innovative Cell Materials and Designs for 300 Mile Range EVs

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Innovative Cell Materials and Design for 300 Mile Range EVs Yimin Zhu, PD/PI OneD Material, LLC (former Nanosys Energy Storage) Palo Alto, California June 16 ~20, 2014 DOE Vehicle Technologies AMR 2014 ES130_zhu_2014_p This presentation does not contain any proprietary, confidential, or otherwise restricted information TM * Barriers addressed - Performance: Low Wh/kg & Wh/L - Life: Poor deep discharge cycles - Cost: High $/kWh * Targets Anode: >700 mAh/g 1,600 mAh/g >800 cycles

  7. Fact #729: May 28, 2012 Secondary Household Vehicles Travel Fewer Miles |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy 9: May 28, 2012 Secondary Household Vehicles Travel Fewer Miles Fact #729: May 28, 2012 Secondary Household Vehicles Travel Fewer Miles When a household has more than one vehicle, the secondary vehicles travel fewer miles than the primary vehicle. In a two-vehicle household, the second vehicle travels less than half of the miles that the primary vehicle travels in a day. In a six-vehicle household, the sixth vehicle travels fewer than five miles a day. Daily Vehicle

  8. Fact #902: December 7, 2015 Rural versus Urban Vehicle Miles of Travel by

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    State | Department of Energy 2: December 7, 2015 Rural versus Urban Vehicle Miles of Travel by State Fact #902: December 7, 2015 Rural versus Urban Vehicle Miles of Travel by State SUBSCRIBE to the Fact of the Week In the United States, the U.S. Department of Transportation classifies 3.9 million miles of roadway as rural and 1.2 million miles of roadway as urban. Each state has a different travel pattern affecting the proportion of vehicle miles traveled (VMT) on rural versus urban roads.

  9. Fact #938: August 15, 2016 Median All-Electric Vehicle Range Grew from 73 Miles in Model Year 2011 to 83.5 Miles in Model Year 2016- Dataset

    Office of Energy Efficiency and Renewable Energy (EERE)

    Excel file and dataset for Median All-Electric Vehicle Range Grew from 73 Miles in Model Year 2011 to 83.5 Miles in Model Year 2016

  10. Real-time sub-<mi>>ngstrom...

    Office of Scientific and Technical Information (OSTI)

    Real-time sub-<mi>>ngstrom imaging of reversible and irreversible conformations in rhodium catalysts and graphene Kisielowski, Christian; Wang,...

  11. Final Environmental Assessment for the Proposed Consolidation of Certain Dynamic Experimentation Activities at the Two-Mile Mesa Complex Los Alamos National Laboratory, Los Alamos, New Mexico

    SciTech Connect (OSTI)

    N /A

    2003-11-03

    The National Environmental Policy Act of 1969 (NEPA) requires Federal agency officials to consider the environmental consequences of their proposed actions before decisions are made. In complying with NEPA, the United States (U.S.) Department of Energy (DOE), National Nuclear Security Administration (NNSA), follows the Council on Environmental Quality regulations (40 CFR 1500-1508) and DOE's NEPA implementing procedures (10 CFR 1021). The purpose of an environmental assessment (EA) is to provide Federal decision makers with sufficient evidence and analysis to determine whether to prepare an environmental impact statement (EIS) or issue a Finding of No Significant Impact. Los Alamos National Laboratory (LANL) is a national security laboratory located at Los Alamos, New Mexico, that comprises about 40 square miles (mi{sup 2}) (103.6 square kilometers [km{sup 2}]) of buildings, structures, and forested land (Figure 1). It is administered by NNSA for the Federal government and is managed and operated under contract by the University of California (UC). The NNSA must make a decision whether to consolidate and construct new facilities for the Dynamic Experimentation Division (DX) to create a central core area of facilities, including offices, laboratories, and other support structures, at LANL's Two-Mile Mesa Complex, which comprises portions of Technical Area (TA) 6, TA-22, and TA-40. This Proposed Action would involve constructing new buildings; consolidating existing operations and offices; enhancing utilities, roads, and security infrastructure; and demolishing or removing older buildings, structures, and transportables at various technical areas used by DX (Figure 2). This EA has been prepared to assess the potential environmental consequences of this proposed construction, operational consolidation, and demolition project. The objectives of this EA are to (1) describe the underlying purpose and need for NNSA action; (2) describe the Proposed Action and identify and

  12. Results of the radiological survey at Two Mile Creek, Tonawanda, New York (TNY002)

    SciTech Connect (OSTI)

    Murray, M.E.; Rodriguez, R.E.; Uziel, M.S.

    1997-08-01

    At the request of the US Department of Energy (DOE), a team from Oak Ridge National Laboratory conducted a radiological survey at Two Mile Creek, Tonawanda, New York. The survey was performed in November 1991 and May 1996. The purpose of the survey was to determine if radioactive materials from work performed under government contract at the Linde Air Products Division of Union Carbide Corporation, Tonawanda, New York, had been transported into the creek. The survey included a surface gamma scan in accessible areas near the creek and the collection of soil, sediment, and core samples for radionuclide analyses. Survey results indicate that no significant material originating at the Linde plant is presently in the creek. Three of the 1991 soil sample locations on the creek bank and one near the lake contained slightly elevated concentrations of {sup 238}U with radionuclide distributions similar to that found in materials resulting from former processing activities at the Linde site.

  13. Mi GmbH | Open Energy Information

    Open Energy Info (EERE)

    Mi GmbH Jump to: navigation, search Name: Mi GmbH Place: Switzerland Zip: CH-6340 Sector: Solar Product: Baar-based manufacturer and distributor of fruit juices. The firm is also...

  14. miRNAs in brain development

    SciTech Connect (OSTI)

    Petri, Rebecca; Malmevik, Josephine; Fasching, Liana; Åkerblom, Malin; Jakobsson, Johan

    2014-02-01

    MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. In the brain, a large number of miRNAs are expressed and there is a growing body of evidence demonstrating that miRNAs are essential for brain development and neuronal function. Conditional knockout studies of the core components in the miRNA biogenesis pathway, such as Dicer and DGCR8, have demonstrated a crucial role for miRNAs during the development of the central nervous system. Furthermore, mice deleted for specific miRNAs and miRNA-clusters demonstrate diverse functional roles for different miRNAs during the development of different brain structures. miRNAs have been proposed to regulate cellular functions such as differentiation, proliferation and fate-determination of neural progenitors. In this review we summarise the findings from recent studies that highlight the importance of miRNAs in brain development with a focus on the mouse model. We also discuss the technical limitations of current miRNA studies that still limit our understanding of this family of non-coding RNAs and propose the use of novel and refined technologies that are needed in order to fully determine the impact of specific miRNAs in brain development. - Highlights: • miRNAs are essential for brain development and neuronal function. • KO of Dicer is embryonically lethal. • Conditional Dicer KO results in defective proliferation or increased apoptosis. • KO of individual miRNAs or miRNA families is necessary to determine function.

  15. DC Fast Charge Effects on Battery Life and Performance Study - 50,000 Mile Update

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    11 L2 4582 L2 2183 DCFC 2078 DCFC 0-10k Miles (Oct-Jan) 28.6 28.6 32.7 32.5 10-20k Miles (Jan-Mar) 22.7 22.5 27.6 27.3 20-30k Miles (Apr-Jul) 35.7 36.0 39.8 39.5 30-40k Miles (Jul-Oct) 38.2 38.4 40.8 40.6 40-50k Miles (Oct-Mar) 23.2 23.6 27.3 26.8 1. Capacity and Peak Power tests based on tests from USABC Electric Vehicle Battery Test Procedures Manual Revision 2. Electric Vehicle Power Characterization test adapted from the Hybrid Pulse Power Characterization Test from the FreedomCAR Battery

  16. DOE - Office of Legacy Management -- Michigan Velsicol Chemical Corp - MI

    Office of Legacy Management (LM)

    03 Michigan Velsicol Chemical Corp - MI 03 FUSRAP Considered Sites Site: MICHIGAN [VELSICOL] CHEMICAL CORP. (MI.03 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: Velsicol Chemical Corp. MI.03-1 Location: St. Louis , Michigan MI.03-2 Evaluation Year: Circa 1987 MI.03-3 Site Operations: Rare earth processing facility. MI.03-2 Site Disposition: Eliminated - No Authority - NRC survey MI.03-3 Radioactive Materials Handled: Yes Primary Radioactive

  17. DOE - Office of Legacy Management -- Star Cutter Corp - MI 15

    Office of Legacy Management (LM)

    Star Cutter Corp - MI 15 FUSRAP Considered Sites Site: STAR CUTTER CORP. (MI.15) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Farmington , Michigan MI.15-1 Evaluation Year: 1991 MI.15-2 Site Operations: Performed a one time uranium slug drilling operation test in 1956. MI.15-3 MI.15-1 Site Disposition: Eliminated - Potential for contamination considered remote based on limited scope and quantity of materials handled MI.15-2 Radioactive

  18. Closure Report for Corrective Action Unit 407: Roller Coaster RADSAFE Area, Tonopah Test Range, Nevada

    SciTech Connect (OSTI)

    T. M. Fitzmaurice

    2001-12-01

    This closure report (CR) provides documentation for the closure of the Roller Coaster RADSAFE Area (RCRSA) Corrective Action Unit (CAU) 407 identified in the Federal Facility Agreement and Consent Order (FFACO) (Nevada Division of Environmental Protection [NDEP] et al., 1996). CAU 407 is located at the Tonopah Test Range (TTR), Nevada. The TTR is approximately 225 kilometers (km) (140 miles [mi]) northwest of Las Vegas, Nevada (Figure 1). The RCRSA is located on the northeast comer of the intersection of Main Road and Browne's Lake Road, which is approximately 8 km (5 mi) south of Area 3 (Figure 1). The RCRSA was used during May and June of 1963 to decontaminate vehicles, equipment, and personnel from the Double Tracks and Clean Slate tests. Investigation of the RCRSA was conducted from June through November of 1998. A Corrective Action Decision Document (CADD) (U.S. Department of Energy, Nevada Operations Office [DOEN], 1999) was approved in October of 1999. The purpose of this CR is to: Document the closure activities as proposed in the Corrective Action Plan (CAP) (DOEM, 2000). Obtain a Notice of Completion from the NDEP. Recommend the movement of CAU 407 from Appendix III to Appendix IV of the FFACO. The following is the scope of the closure actions implemented for CAU 407: Removal and disposal of surface soils which were over three times background for the area. Soils identified for removal were disposed of at the Area 5 Radioactive Waste Management Site (RWMS) at the Nevada Test Site (NTS). Excavated areas were backfilled with clean borrow soil located near the site. A soil cover was constructed over the waste disposal pit area, where subsurface constituents of concern remain. The site was fenced and posted as an ''Underground Radioactive Material'' area.

  19. Fact #552: January 5, 2009 Vehicle Miles of Travel by Region | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy 2: January 5, 2009 Vehicle Miles of Travel by Region Fact #552: January 5, 2009 Vehicle Miles of Travel by Region Total vehicle miles of travel (VMT) in the U.S. have declined from 2007 to 2008. The latest data available, September 2008, shows a 4.4% decline in travel that varies by region. Comparing September 2007 to September 2008, the South Atlantic and South Gulf regions experienced VMT declines of more than 5%. Total U.S. cumulative VMT for 2008 (January-September) is 3.5%

  20. Fact #616: March 29, 2010 Household Vehicle-Miles of Travel by Trip Purpose

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    | Department of Energy 6: March 29, 2010 Household Vehicle-Miles of Travel by Trip Purpose Fact #616: March 29, 2010 Household Vehicle-Miles of Travel by Trip Purpose In 2009, getting to and from work accounted for about 27% of household vehicle-miles of travel (VMT). Work-related business was 8.4% of VMT in 2001, but declined to 6.7% in 2009, possibly due to advancements in computing technology making it possible for more business to be handled electronically. VMT for shopping was almost

  1. Fact #903: December 14, 2015 Vehicle Miles of Travel is up in 2015 -

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Dataset | Department of Energy 3: December 14, 2015 Vehicle Miles of Travel is up in 2015 - Dataset Fact #903: December 14, 2015 Vehicle Miles of Travel is up in 2015 - Dataset Excel file and dataset for Vehicle Miles of Travel is up in 2015 fotw#903_web.xlsx (17.31 KB) More Documents & Publications Project Reports for Salish and Kootenai Tribes, Confederated Tribes of the Flathead Reservation: S&K Holding Company - 2004 Project 2015 GTO Peer Review Fact #926: May 23, 2016 Petroleum

  2. Fact #860 February 16, 2015 Relationship of Vehicle Miles of Travel and the

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Price of Gasoline - Dataset | Department of Energy 0 February 16, 2015 Relationship of Vehicle Miles of Travel and the Price of Gasoline - Dataset Fact #860 February 16, 2015 Relationship of Vehicle Miles of Travel and the Price of Gasoline - Dataset Excel file and dataset for Relationship of Vehicle Miles of Travel and the Price of Gasoline fotw#860_web.xlsx (30.54 KB) More Documents & Publications Fact #906: January 4, 2016 VMT and the Price of Gasoline Typically Move in Opposition -

  3. Fact #902: December 7, 2015 Rural versus Urban Vehicle Miles of Travel by

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    State - Dataset | Department of Energy 2: December 7, 2015 Rural versus Urban Vehicle Miles of Travel by State - Dataset Fact #902: December 7, 2015 Rural versus Urban Vehicle Miles of Travel by State - Dataset Excel file and dataset for Rural versus Urban Vehicle Miles of Travel by State fotw#902_web.xlsx (177.48 KB) More Documents & Publications Fact #904: December 21, 2015 Gross Domestic Product and Vehicle Travel: Both Increased during 2015 - Dataset Fact #906: January 4, 2016 VMT

  4. 51-Mile Hydroelectric Power Project Demonstration of new methodologies to reduce the LCOE for small, hydropower development

    Broader source: Energy.gov [DOE]

    51-Mile Hydroelectric Power Project Demonstration of new methodologies to reduce the LCOE for small, hydropower development

  5. Fact #903: December 14, 2015 Vehicle Miles of Travel is up in...

    Broader source: Energy.gov (indexed) [DOE]

    Vehicle Miles of Travel is up in 2015 fotw903web.xlsx (17.31 KB) More Documents & Publications Project Reports for Salish and Kootenai Tribes, Confederated Tribes of the Flathead ...

  6. Fact #728: May 21, 2012 Average Trip Length is Less Than Ten Miles

    Broader source: Energy.gov [DOE]

    The average trip length (one-way) is 9.7 miles according to the 2009 Nationwide Personal Transportation Survey. Trip lengths vary by the purpose of the trip. Shopping and family/personal business...

  7. Bureaucracy in crisis: Three Mile Island, the shuttle Challenger, and risk assessment

    SciTech Connect (OSTI)

    Casamayou, M.H.

    1995-07-01

    This book is a study in organizational theory about how technological bureaucracies perceive, communicate about, and respond to potential risks to public safety, using Three mile island and the Challenger accident as examples.

  8. Fact #640: September 13, 2010 Monthly Trends in Vehicle Miles of Travel

    Broader source: Energy.gov [DOE]

    Vehicle travel in the U.S. varies by month. There are many reasons for this, including the fact that some months are shorter than others. The vehicle miles of travel (VMT) recorded in February is...

  9. Table 5.1. U.S. Number of Vehicles, Vehicle-Miles, Motor Fuel...

    U.S. Energy Information Administration (EIA) Indexed Site

    Energy Information AdministrationHousehold Vehicles Energy Consumption 1994 43 Table 5.1. U.S. Number of Vehicles, Vehicle-Miles, Motor Fuel Consumption and Expenditures, 1994...

  10. 100,000-Mile Evaluation of Transit Buses Operated on Biodiesel...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Evaluation of Transit Buses Operated on Biodiesel Blends (B20) 100,000-Mile Evaluation of Transit Buses Operated on Biodiesel Blends (B20) Presentation given at DEER 2006, ...

  11. Fact #860 February 16, 2015 Relationship of Vehicle Miles of Travel and the Price of Gasoline

    Broader source: Energy.gov [DOE]

    The prices of gasoline and diesel fuel affect the transportation sector in many ways. For example, fuel prices can impact the number of miles driven and affect the choices consumers make when...

  12. Long-term Decline of Aggregate Fuel Use per Cargo-ton-mile of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Long-term Decline of Aggregate Fuel Use per Cargo-ton-mile of Commercial Trucking; A Key Enabler of Expanded U.S. Trade and Economic Growth Poster presentation at the 2007 Diesel ...

  13. No Recordable Accidents in 17,000 Waste Shipments Across 3.4 Million Miles

    Broader source: Energy.gov [DOE]

    WASHINGTON, D.C. – No U.S. Department of Transportation recordable accidents resulted from DOE’s nearly 17,000 radioactive, hazardous material and waste shipments across 3.4 million miles in fiscal 2015.

  14. Table 5.1. U.S. Number of Vehicles, Vehicle-Miles, Motor Fuel...

    U.S. Energy Information Administration (EIA) Indexed Site

    Table 5.1. U.S. Number of Vehicles, Vehicle-Miles, Motor Fuel Consumption and Expenditures, 1994 (Continued) 1993 Household and 1994 Vehicle Characteristics RSE Column Factor:...

  15. Toward 300 Miles on a Single Charge? | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Toward 300 Miles on a Single Charge? News News Home Featured Articles 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Science Headlines Science Highlights Presentations & Testimony News Archives Communications and Public Affairs Contact Information Office of Science U.S. Department of Energy 1000 Independence Ave., SW Washington, DC 20585 P: (202) 586-5430 11.27.13 Toward 300 Miles on a Single Charge? Berkeley Lab scientists design a high-performance, long cycle-life

  16. Innovative Cell Materials and Designs for 300 Mile Range EVs | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy 2 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting es130_zhu_2012_p.pdf (1.04 MB) More Documents & Publications Vehicle Technologies Office Merit Review 2014: Innovative Cell Materials and Design for 300 Mile Range EVs Innovative Cell Materials and Designs for 300 Mile Range EVs U.S. Battery R&D Progress and Plans

  17. Innovative Cell Materials and Designs for 300 Mile Range EVs | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy 3 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting es130_zhu_2013_p.pdf (1.37 MB) More Documents & Publications Vehicle Technologies Office Merit Review 2014: Innovative Cell Materials and Design for 300 Mile Range EVs Innovative Cell Materials and Designs for 300 Mile Range EVs Vehicle Technologies Office Merit Review 2016: Advanced High-Performance Batteries for Electric Vehicle (EV) Applications

  18. 1982 worldwide pipeline construction will top 21,900 miles, $9. 5 billion

    SciTech Connect (OSTI)

    Hall, D.

    1982-07-01

    Reports that pipeline construction slowed slightly in 1982 because of lowered economic activity worldwide, with an upturn forecast for 1983. Explains that need for new pipelines to transport increasing amounts of oil and gas energy now being discovered, plus use of pipelines to transport other commodities in increasing amounts, has created a backlog of demand for facilities. Indicates that commodities suited for pipeline transport and getting consideration include crude oil; refined products; natural gas liquids; LPG; coal slurries; carbon dioxide (used for enhanced oil recovery); chemicals such as ammonia, ethane, ethylene, and similar petrochemical feedstocks; industrial gases such as oxygen, nitrogen; and solids slurries such as ores, wood chips, and other non-soluble minerals, even items such as wood chips and wood pulp for paper-making. Reveals that there are 10,396 miles of coal slurry pipeline planned for the US and 500 miles in Canada. Major US projects underway in the gas pipeline field include the 797-mile, 36-in. Trailblazer system in Nebraska, Wyoming, Colorado, and Utah. Products/ LPG/NGL pipelines underway include 105 miles of dual 4 and 6-in. line in Kansas. Crude pipeline activity includes 100 miles of 12-in. in California and 80 miles of 4 thru 40-in. in Alaska on the North Slope. Updates plans in Canada, Scotland, Denmark, Ireland, France, the Middle East, Australia, Southeast Asia, Mexico, South America and the USSR.

  19. Corrective Action Investigation Plan for Corrective Action Unit 551: Area 12 Muckpiles, Nevada Test Site, Nevada, Rev. No. 0

    SciTech Connect (OSTI)

    Robert F. Boehlecke

    2004-06-01

    This Corrective Action Investigation Plan (CAIP) contains project-specific information including facility descriptions, environmental sample collection objectives, and criteria for conducting site investigation activities at Corrective Action Unit (CAU) 551, Area 12 muckpiles, Nevada Test Site (NTS), Nevada. This CAIP has been developed in accordance with the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996) that was agreed to by the State of Nevada, the U.S. Department of Energy (DOE), and the U.S. Department of Defense. Corrective Action Unit 551 is located in Area 12 of the NTS, which is approximately 110 miles (mi) northwest of Las Vegas, Nevada (Figure 1-1). Area 12 is approximately 40 miles beyond the main gate to the NTS. Corrective Action Unit 551 is comprised of the four Corrective Action Sites (CASs) shown on Figure 1-1 and listed below: (1) 12-01-09, Aboveground Storage Tank and Stain; (2) 12-06-05, Muckpile; (3) 12-06-07, Muckpile; and (4) 12-06-08, Muckpile. Corrective Action Site 12-01-09 is located in Area 12 and consists of an above ground storage tank (AST) and associated stain. Corrective Action Site 12-06-05 is located in Area 12 and consists of a muckpile associated with the U12 B-Tunnel. Corrective Action Site 12-06-07 is located in Area 12 and consists of a muckpile associated with the U12 C-, D-, and F-Tunnels. Corrective Action Site 12-06-08 is located in Area 12 and consists of a muckpile associated with the U12 B-Tunnel. In keeping with common convention, the U12B-, C-, D-, and F-Tunnels will be referred to as the B-, C-, D-, and F-Tunnels. The corrective action investigation (CAI) will include field inspections, radiological surveys, and sampling of media, where appropriate. Data will also be obtained to support waste management decisions.

  20. Corrective Action Investigation Plan for Corrective Action Unit 551: Area 12 Muckpiles, Nevada Test Site, Nevada, Rev. No.: 0

    SciTech Connect (OSTI)

    David A. Strand

    2004-06-01

    This Corrective Action Investigation Plan (CAIP) contains project-specific information including facility descriptions, environmental sample collection objectives, and criteria for conducting site investigation activities at Corrective Action Unit (CAU) 551, Area 12 muckpiles, Nevada Test Site (NTS), Nevada. This CAIP has been developed in accordance with the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996) that was agreed to by the State of Nevada, the U.S. Department of Energy (DOE), and the U.S. Department of Defense. Corrective Action Unit 551 is located in Area 12 of the NTS, which is approximately 110 miles (mi) northwest of Las Vegas, Nevada (Figure 1-1). Area 12 is approximately 40 miles beyond the main gate to the NTS. Corrective Action Unit 551 is comprised of the four Corrective Action Sites (CASs) shown on Figure 1-1 and listed below: (1) 12-01-09, Aboveground Storage Tank and Stain; (2) 12-06-05, Muckpile; (3) 12-06-07, Muckpile; and (4) 12-06-08, Muckpile. Corrective Action Site 12-01-09 is located in Area 12 and consists of an above ground storage tank (AST) and associated stain. Corrective Action Site 12-06-05 is located in Area 12 and consists of a muckpile associated with the U12 B-Tunnel. Corrective Action Site 12-06-07 is located in Area 12 and consists of a muckpile associated with the U12 C-, D-, and F-Tunnels. Corrective Action Site 12-06-08 is located in Area 12 and consists of a muckpile associated with the U12 B-Tunnel. In keeping with common convention, the U12B-, C-, D-, and F-Tunnels will be referred to as the B-, C-, D-, and F-Tunnels. The corrective action investigation (CAI) will include field inspections, radiological surveys, and sampling of media, where appropriate. Data will also be obtained to support waste management decisions.

  1. DOE - Office of Legacy Management -- Wolverine Tube Division - MI 05

    Office of Legacy Management (LM)

    Wolverine Tube Division - MI 05 FUSRAP Considered Sites Site: Wolverine Tube Division (MI.05) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: Wolverine Tube Division of Calumet & Hecla Consolidated Copper Co. Star Tool Hermes Automotive Manufacturing Corporation MI.05-1 MI.05-2 Location: 1411 Central Avenue , Detroit , Michigan MI.05-3 Evaluation Year: 1990 MI.05-2 Site Operations: 1943 - Conducted research and development of methods for spinning

  2. DOE - Office of Legacy Management -- Adrian - MI 01

    Office of Legacy Management (LM)

    Adrian - MI 01 FUSRAP Considered Sites Adrian, MI Alternate Name(s): Bridgeport Brass Co. Special Metals Extrusion Plant Bridgeport Brass Company General Motors General Motors Company, Adrian MI.01-1 Location: 1450 East Beecher Street, Adrian, Michigan MI.01-3 Historical Operations: Performed uranium extrusion research and development and metal fabrication work for the AEC using uranium, thorium, and plutonium. MI.01-2 Eligibility Determination: Eligible MI.01-1 Radiological Survey(s):

  3. DOE - Office of Legacy Management -- Oliver Corp - MI 11

    Office of Legacy Management (LM)

    Oliver Corp - MI 11 FUSRAP Considered Sites Site: OLIVER CORP. (MI.11 ) Eliminated from further consideration under FUSRAP - Referred to NRC Designated Name: Not Designated Alternate Name: Behnke Warehousing Incorporated MI.11-1 Location: 433 East Michigan Avenue , Battle Creek , Michigan MI.11-1 Evaluation Year: 1986 MI.11-4 Site Operations: Conducted production scale briquetting of green salt and magnesium blend under AEC license Nos. SNM-591, SUB-579, and C-3725. MI.11-1 MI.11-3 Site

  4. The NuMI Neutrino Beam

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Adamson, P.; Anderson, K.; Andrews, M.; Andrews, R.; Anghel, I.; Augustine, D.; Aurisano, A.; Avvakumov, S.; Ayres, D. S.; Baller, B.; et al

    2015-10-20

    Our paper describes the hardware and operations of the Neutrinos at the Main Injector (NuMI) beam at Fermilab. It elaborates on the design considerations for the beam as a whole and for individual elements. The most important part of our design details pertaining to individual components is described. Beam monitoring systems and procedures, including the tuning and alignment of the beam and NuMI long-term performance, are also discussed.

  5. A reevaluation of cancer incidence near the Three Mile Island nuclear plant: The collision of evidence and assumptions

    SciTech Connect (OSTI)

    Wing, S.; Richardson, D.; Armstrong, D.; Crawford-Brown, D.

    1997-01-01

    Previous studies concluded that there was no evidence that the 1979 nuclear accident at Three Mile Island (TMI) affected cancer incidence in the surrounding area; however, there were logical and methodological problems in earlier reports that led us to reconsider data previously collected. A 10-mile area around TMI was divided into 69 study tracts, which were assigned radiation dose estimates based on radiation readings and models of atmospheric dispersion. Incident cancers from 1975 to 1985 were ascertained from hospital records and assigned to study tracts. Associations between accident doses and incidence rates of leukemia, lung cancer, and all cancer were assessed using relative dose estimates calculated by the earlier investigators. Adjustments were made for age, sex, socioeconomic characteristics, and preaccident variation in incidence. Considering a 2-year latency, the estimated percent increase per dose unit {plus_minus} standard error was 0.020 {plus_minus} 0.012 for all cancer, 0.082 {plus_minus} 0.032 for lung cancer, and 0.116 {plus_minus} 0.067 for leukemia. Adjustment for socioeconomic variables increased the estimates to 0.034 {plus_minus} 0.013, 0.103 {plus_minus} 0.035, and 0.139 {plus_minus} 0.073 for all cancer, lung cancer, and leukemia, respectively. Associations were generally larger considering a 5-year latency, but were based on smaller numbers of cases. Results support the hypothesis that radiation doses are related to increased cancer incidence around TMI. The analysis avoids medical detection bias, but suffers from inaccurate dose classification; therefore, results may underestimate the magnitude of the association between radiation and cancer incidence. These associations would not be expected, based on previous estimates of near-background levels of radiation exposure following the accident. 35 refs., 3 tabs.

  6. To Pluto and Beyond: Powering New Horizons' 3-Billion-Mile Journey |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy To Pluto and Beyond: Powering New Horizons' 3-Billion-Mile Journey To Pluto and Beyond: Powering New Horizons' 3-Billion-Mile Journey July 15, 2015 - 11:23am Addthis This image of Pluto, taken by New Horizons after a 9 1/2-year journey, is our highest-resolution photo of the dwarf planet since its discovery by Clyde Tombaugh in 1930. | Photo courtesy of NASA. This image of Pluto, taken by New Horizons after a 9 1/2-year journey, is our highest-resolution photo of the

  7. Operational and Environmental Monitoring Within a Three-Mile Radius of Project Rulison

    Office of Legacy Management (LM)

    FOURTH QUARTER 20 08 REPORT Operational and Environmental Monitoring Within a Three-Mile Radius of Project Rulison F F Prepared by: M A R C H 2 0 0 9 FOURTH QUARTER 2008 REPORT OPERATIONAL AND ENVIRONMENTAL MONITORING WITHIN A THREE-MILE RADIUS OF PROJECT RULISON Prepared for: Noble Energy Inc. EnCana Oil & Gas (USA) Inc. Williams Production RMT Inc. Prepared by: URS Corporation 8181 East Tufts Avenue Denver, CO 80237 March 26, 2009 Rulison Fourth Quarter 2008 Report March 2009 i TABLE OF

  8. Full Useful Life (120,000 miles) Exhaust Emission Performance of a NOx

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Adsorber and Diesel Particle Filter Equipped Passenger Car and Medium-Duty Engine in Conjunction with Ultralow-Sulfur Fuel | Department of Energy Full Useful Life (120,000 miles) Exhaust Emission Performance of a NOx Adsorber and Diesel Particle Filter Equipped Passenger Car and Medium-Duty Engine in Conjunction with Ultralow-Sulfur Fuel Full Useful Life (120,000 miles) Exhaust Emission Performance of a NOx Adsorber and Diesel Particle Filter Equipped Passenger Car and Medium-Duty Engine in

  9. 100,000-Mile Evaluation of Transit Buses Operated on Biodiesel Blends (B20)

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    | Department of Energy 00,000-Mile Evaluation of Transit Buses Operated on Biodiesel Blends (B20) 100,000-Mile Evaluation of Transit Buses Operated on Biodiesel Blends (B20) Presentation given at DEER 2006, August 20-24, 2006, Detroit, Michigan. Sponsored by the U.S. DOE's EERE FreedomCar and Fuel Partnership and 21st Century Truck Programs. 2006_deer_barnitt.pdf (575.91 KB) More Documents & Publications Recent Research to Address Technical Barriers to Increased Use of Biodiesel Impact

  10. DOE - Office of Legacy Management -- Detrex Corp - MI 10

    Office of Legacy Management (LM)

    Detrex Corp - MI 10 FUSRAP Considered Sites Site: Detrex Corp. (MI.10 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Detroit , Michigan MI.10-1 Evaluation Year: 1987 MI.10-2 Site Operations: Conducted experimental runs relative to pickling/degreasing of one handful of uranium turnings MI.10-1 Site Disposition: Eliminated - Potential for contamination considered remote due to small quantity of material handled - There is no

  11. Methodology for Calculating Cost-per-Mile for Current and Future Vehicle Powertrain Technologies, with Projections to 2024: Preprint

    SciTech Connect (OSTI)

    Ruth, M.; Timbario, T. A.; Timbario, T. J.; Laffen, M.

    2011-01-01

    Currently, several cost-per-mile calculators exist that can provide estimates of acquisition and operating costs for consumers and fleets. However, these calculators are limited in their ability to determine the difference in cost per mile for consumer versus fleet ownership, to calculate the costs beyond one ownership period, to show the sensitivity of the cost per mile to the annual vehicle miles traveled (VMT), and to estimate future increases in operating and ownership costs. Oftentimes, these tools apply a constant percentage increase over the time period of vehicle operation, or in some cases, no increase in direct costs at all over time. A more accurate cost-per-mile calculator has been developed that allows the user to analyze these costs for both consumers and fleets. The calculator was developed to allow simultaneous comparisons of conventional light-duty internal combustion engine (ICE) vehicles, mild and full hybrid electric vehicles (HEVs), and fuel cell vehicles (FCVs). This paper is a summary of the development by the authors of a more accurate cost-per-mile calculator that allows the user to analyze vehicle acquisition and operating costs for both consumer and fleets. Cost-per-mile results are reported for consumer-operated vehicles travelling 15,000 miles per year and for fleets travelling 25,000 miles per year.

  12. Crisis contained, The Department of Energy at Three Mile Island: a history

    SciTech Connect (OSTI)

    Cantelon, P L; Williams, R C

    1980-12-01

    An account is given of the response of US DOE to the Three Mile Island-2 accident on March 28, 1979. The accident is treated as though it was a military battle. A synoptic chronologgy of the accident events and of DOE and other responses is included. (DLC)

  13. Hawaii Geothermal Area | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Hawaii Geothermal Area Hawaii Geothermal Area The Hawaii geothermal area includes the Puna Geothermal Venture, which is located about 21 miles south of Hilo on the Big Island of Hawaii. The facility is situated along the Lower East Rift Zone of the Kilauea Volcano. At the Puna Geothermal Venture, geothermal fluid is brought to the surface through production wells, which tap into the resource at a depth of almost a mile. The steam, along with its non-condensable gases, is routed to the power

  14. Robin Miles

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Stockpile Stewardship National Security National Competitiveness Fusion and Ignition Experiments Fast Ignition Energy for the Future How to Make a Star How ICF Works Discovery ...

  15. Loss of expression of miR-335 is implicated in hepatic stellate cell migration and activation

    SciTech Connect (OSTI)

    Chen, Chao; Wu, Chao-Qun; Zhang, Zong-Qi; Yao, Ding-Kang; Zhu, Liang

    2011-07-15

    Activation and migration of resident stellate cells (HSCs) within the hepatic space of Disse play an important role in hepatic fibrosis, which accounts for the increased numbers of activated HSCs in areas of inflammation during hepatic fibrosis. Currently, microRNAs have been found to play essential roles in HSC differentiation, proliferation, apoptosis, fat accumulation and collagen production. However, little is known about microRNA mediated HSC activation and migration. In this study, the miRNA expression profiles of quiescent HSCs, partially activated HSCs and fully activated HSCs were compared in pairs. Gene ontology (GO) and GO-Map network analysis indicated that the activation of HSCs was regulated by microRNAs. Among them miR-335 was confirmed to be significantly reduced during HSC activation by qRT-PCR, and restoring expression of miR-335 inhibited HSC migration and reduced {alpha}-SMA and collagen type I. Previous study revealed that tenascin-C (TNC), an extracellular matrix glycoprotein involved in cell migration, might be a target of miR-335. Therefore, we further studied the TNC expression in miR-335 over-expressed HSCs. Our data showed that exogenous TNC could enhance HSC migration in vitro and miR-335 restoration resulted in a significant inhibition of TNC expression. These results demonstrated that miR-335 restoration inhibited HSC migration, at least in part, via downregulating the TNC expression.

  16. DOE - Office of Legacy Management -- Naval Ordnance Plant - MI...

    Office of Legacy Management (LM)

    Eliminated from further consideration under FUSRAP - Referred to DoD for action Designated ... MI.0-03-1 Site Disposition: Eliminated - No Authority - Referred to DoD MI.0-03-1 ...

  17. miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor

    SciTech Connect (OSTI)

    Park, Jong-Kook; Henry, Jon C.; Jiang, Jinmai; Esau, Christine; Gusev, Yuriy; Lerner, Megan R.; Postier, Russell G.; Brackett, Daniel J.; Schmittgen, Thomas D.

    2011-03-25

    Research highlights: {yields} The expression of miR-132 and miR-212 are significantly increased in pancreatic cancer. {yields} miR-132 and miR-212 target the tumor suppressor pRb, resulting in enhanced proliferation. {yields} miR-132 and miR-212 expression is increased by a {beta}2 adrenergic receptor agonist, suggesting a novel mechanism for pancreatic cancer progression. -- Abstract: Numerous microRNAs (miRNAs) are reported as differentially expressed in cancer, however the consequence of miRNA deregulation in cancer is unknown for many miRNAs. We report that two miRNAs located on chromosome 17p13, miR-132 and miR-212, are over-expressed in pancreatic adenocarcinoma (PDAC) tissues. Both miRNAs are predicted to target the retinoblastoma tumor suppressor, Rb1. Validation of this interaction was confirmed by luciferase reporter assay and western blot in a pancreatic cancer cell line transfected with pre-miR-212 and pre-miR-132 oligos. Cell proliferation was enhanced in Panc-1 cells transfected with pre-miR-132/-212 oligos. Conversely, antisense oligos to miR-132/-212 reduced cell proliferation and caused a G{sub 2}/M cell cycle arrest. The mRNA of a number of E2F transcriptional targets were increased in cells over expressing miR-132/-212. Exposing Panc-1 cells to the {beta}2 adrenergic receptor agonist, terbutaline, increased the miR-132 and miR-212 expression by 2- to 4-fold. We report that over-expression of miR-132 and miR-212 result in reduced pRb protein in pancreatic cancer cells and that the increase in cell proliferation from over-expression of these miRNAs is likely due to increased expression of several E2F target genes. The {beta}2 adrenergic pathway may play an important role in this novel mechanism.

  18. Reactor engineering support of operations at Three Mile Island nuclear station

    SciTech Connect (OSTI)

    Tropasso, R.T.

    1995-12-31

    The purpose of this paper is to detail the activities in which plant nuclear engineering personnel provide direct support to plant operations. The specific activities include steady-state, transient, and shutdown/refueling operation support as well as special project involvement. The paper is intended to describe the experiences at Three Mile Island (TMI) in which significant benefit to the success of the activity is achieved through the support of the nuclear engineers.

  19. Summary Report of Commercial reactor Criticality Data for Three Mile Island Unit 1

    SciTech Connect (OSTI)

    Larry B. Wimmer

    2001-08-29

    The objective of the ''Summary Report of Commercial Reactor Criticality Data for Three Mile Island Unit I'' is to present the CRC data for the TMI-1 reactor. Results from the CRC evaluations will support the development and validation of the neutronics models used for criticality analyses involving commercial spent nuclear fuel. These models and their validation are discussed in the ''Disposal Criticality Analysis Methodology Topical Report'' (YMP 2000).

  20. Nondestructive techniques for assaying fuel debris in piping at Three Mile Island Unit 2

    SciTech Connect (OSTI)

    Vinjamuri, K.; McIsaac, C.V.; Beller, L.S.; Isaacson, L.; Mandler, J.W.; Hobbins, R.R. Jr.

    1981-11-01

    Four major categories of nondestructive techniques - ultrasonic, passive gamma ray, infrared detection, and remote video examination - have been determined to be feasible for assaying fuel debris in the primary coolant system of the Three Mile Island Unit 2 (TMI-2) Reactor. Passive gamma ray detection is the most suitable technique for the TMI-2 piping; however, further development of this technique is needed for specific application to TMI-2.

  1. “Nodal Gap” induced by the incommensurate diagonal spin density modulation in underdoped high- <mi>Tmi>c> superconductors

    SciTech Connect (OSTI)

    Zhou, Tao; Gao, Yi; Zhu, Jian -Xin

    2015-03-07

    Recently it was revealed that the whole Fermi surface is fully gapped for several families of underdoped cuprates. The existence of the finite energy gap along the <mi>d>-wave nodal lines (nodal gap) contrasts the common understanding of the <mi>d>-wave pairing symmetry, which challenges the present theories for the high-<mi>Tmi><mi>c>superconductors. Here we propose that the incommensurate diagonal spin-density-wave order can account for the above experimental observation. The Fermi surface and the local density of states are also studied. Our results are in good agreement with many important experiments in high-<mi>Tmi><mi>c>superconductors.

  2. Characterization of function and regulation of miR-24-1 and miR-31

    SciTech Connect (OSTI)

    Sun Fenyong; Wang Jiayi; Pan Qiuhui; Yu Yongchun; Zhang Yue; Wan Yang; Wang Ju; Li Xiaoyan; Hong An

    2009-03-13

    To date, numerous microRNAs (miRNAs) have been discovered. However, the function of these miRNAs is largely unknown. While our knowledge of miRNA post-transcriptional processing has greatly expanded in recent years, we have a limited understanding of the regulation and transcription of miRNA genes. In this study, we characterized two BMP-2 upregulated miRNAs, miR-24-1 and miR-31, in mesenchymal stem cells and showed their opposing function in controlling cellular proliferation, and adipogenesis. Furthermore, we are the first to identify and characterize mouse intronic miR-23b{approx}27b{approx}24-1 and intergenic miR-31 genes. Moreover, we found that pri-miR-23b, pri-miR-27b, and pri-miR-24-1 are transcribed independently and their expression profiles are unique when cells are treated with BMP-2, even though they are located closely together.

  3. Compilation of Earthquakes from 1850-2007 within 200 miles of the Idaho National Laboratory

    SciTech Connect (OSTI)

    N. Seth Carpenter

    2010-07-01

    An updated earthquake compilation was created for the years 1850 through 2007 within 200 miles of the Idaho National Laboratory. To generate this compilation, earthquake catalogs were collected from several contributing sources and searched for redundant events using the search criteria established for this effort. For all sets of duplicate events, a preferred event was selected, largely based on epicenter-network proximity. All unique magnitude information for each event was added to the preferred event records and these records were used to create the compilation referred to as “INL1850-2007”.

  4. Examination of claims of Miles et al. in Pons-Fleischmann-type cold fusion experiments

    SciTech Connect (OSTI)

    Jones, S.E.; Hansen, L.D.

    1995-05-04

    In cold fusion experiments conducted at the Naval Research Laboratory in China Lake, M. H. Miles and co-workers claim to have produced excess heat correlated with helium-4 production, X-rays, and Geiger-counter excitation. However, scrutiny of the claims shows that unreliable calorimetric and nuclear-product detection methods were used. Moreover, inconsistencies and errors are found in the data and data analysis. The juxtaposition of several poor techniques and inconsistent data does not make a compelling case for cold fusion. We conclude that the evidence for cold fusion from these efforts is far from compelling. 20 refs., 2 figs., 2 tabs.

  5. 18 MILES NORTH OF PHlLADEl.PHlA HATBORO, PA. August

    Office of Legacy Management (LM)

    8 MILES NORTH OF PHlLADEl.PHlA HATBORO, PA. August 27, 1948 ! ! Frank Giaccio' Commission / I This follows my letter of August ZOth, in which I promised to advise you of our thoughts concerning beryllium, after I had completed a series of con- tacts with both.Government and private,grou?s and had an opportunity to evaluate the possibilities of using our process from the point of view of industrial research. By this, I meanthe possibility of the research leading into substantial production of

  6. Tables of co-located geothermal-resource sites and BLM Wilderness Study Areas

    SciTech Connect (OSTI)

    Foley, D.; Dorscher, M.

    1982-11-01

    Matched pairs of known geothermal wells and springs with BLM proposed Wilderness Study Areas (WSAs) were identified by inspection of WSA and Geothermal resource maps for the states of Arizona, California, Colorado, Idaho, Montana, Nevada, New Mexico, Oregon, Utah, Washington and Wyoming. A total of 3952 matches, for geothermal sites within 25 miles of a WSA, were identified. Of these, only 71 (1.8%) of the geothermal sites are within one mile of a WSA, and only an additional 100 (2.5%) are within one to three miles. Approximately three-fourths of the matches are at distances greater than ten miles. Only 12 of the geothermal sites within one mile of a WSA have surface temperatures reported above 50/sup 0/C. It thus appears that the geothermal potential of WSAs overall is minimal, but that evaluation of geothermal resources should be considered in more detail for some areas prior to their designation as Wilderness.

  7. Laboratory measurement verification of laser hazard analysis for miles weapon simulators used in force on force exercises.

    SciTech Connect (OSTI)

    Augustoni, Arnold L.

    2006-08-01

    Due to the change in the batteries used with the Small Arm Laser Transmitters (SALT) from 3-volts dc to 3.6-volts dc and changes to SNL MILES operating conditions, the associated laser hazards of these units required re-evaluation to ensure that the hazard classification of the laser emitters had not changed as well. The output laser emissions of the SNL MILES, weapon simulators and empire guns, used in Force-On-Force (FOF) training exercises, was measured in accordance to the ANSI Standard Z136.4-2005, ''Recommended Practice for Laser Safety Measurements for Hazard Evaluation''. The laser hazard class was evaluated in accordance with the ANSI Standard Z136.1-2000, ''Safe Use of Lasers'', using ''worst'' case conditions associated with these MILES units. Laser safety assessment was conducted in accordance with the ANSI Standard Z136.6-2005, ''Safe Use of Lasers Outdoors''. The laser hazard evaluation of these MILES laser emitters was compared to and supersedes SAND Report SAND2002-0246, ''Laser Safety Evaluation of the MILES and Mini MILES Laser Emitting Components'', which used ''actual'' operating conditions of the laser emitters at the time of its issuance.

  8. DOE - Office of Legacy Management -- Dow Chemical Co - Midland - MI 06

    Office of Legacy Management (LM)

    Midland - MI 06 FUSRAP Considered Sites Site: Dow Chemical Co. - Midland (MI.06 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Midland , Michigan MI.06-1 Evaluation Year: Circa 1987 MI.06-2 Site Operations: Conducted development work for production of magnesium-thorium alloys. MI.06-1 Site Disposition: Eliminated - AEC licensed site MI.06-1 MI.06-2 Radioactive Materials Handled: Yes Primary Radioactive Materials Handled:

  9. Magnetocrystalline anisotropy in <mi>UMn>2<mi>Ge>2 and related Mn-based actinide ferromagnets

    SciTech Connect (OSTI)

    Parker, David S.; Ghimire, Nirmal; Singleton, John; Thompson, J. D.; Bauer, Eric D.; Baumbach, Ryan; Mandrus, David; Li, Ling; Singh, David J.

    2015-05-04

    We present magnetization isotherms in pulsed magnetic fields up to 62 Tesla, supported by first principles calculations, demonstrating a huge uniaxial magnetocrystalline anisotropy energy - approximately 20 MJ/m3 - in <mi>UMn>2<mi>Ge>2. This large anisotropy results from the extremely strong spin-orbit coupling affecting the uranium 5 f electrons, which in the calculations exhibit a substantial orbital moment exceeding 2 μB. Finally, we also find from theoretical calculations that a number of isostructural Mn-actinide compounds are expected to have similarly large anisotropy.

  10. ,"Detroit, MI Natural Gas Pipeline Imports From Canada (MMcf...

    U.S. Energy Information Administration (EIA) Indexed Site

    ,"Worksheet Name","Description"," Of Series","Frequency","Latest Data for" ,"Data 1","Detroit, MI Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2014 ,"Release...

  11. CURRENT APPLICATIONS OF THREE MILE ISLAND-2 CORE AND DEBRIS HANDLING AT THE IDAHO NATIONAL LABORATORY

    SciTech Connect (OSTI)

    Carmack, William Jonathan; Braase, Lori Ann

    2015-09-01

    Fuel recovery from severe accidents requires careful planning and execution. The Idaho National Laboratory played a key role in the Three Mile Island (TMI) fuel and core recovery. This involved technology development to locate and handle the damaged fuel; characterization of fuel and debris; analysis of fuel interaction with structural components and materials; development of fuel drying technology for long-term storage. However, one of the critical activities from the TMI project was the extensive effort document all the activities and archive the reports and photos. A historical review of the TMI project at the INL leads to the identification of current applications and considerations for facility designs, fuel handling, robotic applications, material characterization, etc.

  12. Corrective Action Decision Document/Closure Report for Corrective Action Unit 529: Area 25 Contaminated Materials, Nevada Test Site, Nevada, Rev. No.: 1

    SciTech Connect (OSTI)

    Robert F. Boehlecke

    2004-11-01

    This Corrective Action Decision Document (CADD)/Closure Report (CR) has been prepared for Corrective Action Unit (CAU) 529, Area 25 Contaminated Materials, Nevada Test Site (NTS), Nevada, in accordance with the ''Federal Facility Agreement and Consent Order'' (FFACO) that was agreed to by the State of Nevada, U.S. Department of Energy (DOE), and the U.S. Department of Defense (FFACO, 1996). The NTS is approximately 65 miles (mi) northwest of Las Vegas, Nevada (Figure 1-1). Corrective Action Site (CAS) 25-23-17, Contaminated Wash, is the only CAS in CAU 529 and is located in Area 25 of the NTS, in Nye County, Nevada (Figure 1-2). Corrective Action Site 25-23-17, Contaminated Wash, was divided into nine parcels because of the large area impacted by past operations and the complexity of the source areas. The CAS was subdivided into separate parcels based on separate and distinct releases as determined and approved in the Data Quality Objectives (DQO) process and Corrective Action Investigation Plan (CAIP). Table 1-1 summarizes the suspected sources for the nine parcels. Corrective Action Site 25-23-17 is comprised of the following nine parcels: (1) Parcel A, Kiwi Transient Nuclear Test (TNT) 16,000-foot (ft) Arc Area (Kiwi TNT); (2) Parcel B, Phoebus 1A Test 8,000-ft Arc Area (Phoebus); (3) Parcel C, Topopah Wash at Test Cell C (TCC); (4) Parcel D, Buried Contaminated Soil Area (BCSA) l; (5) Parcel E, BCSA 2; (6) Parcel F, Borrow Pit Burial Site (BPBS); (7) Parcel G, Drain/Outfall Discharges; (8) Parcel H, Contaminated Soil Storage Area (CSSA); and (9) Parcel J, Main Stream/Drainage Channels.

  13. Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells

    SciTech Connect (OSTI)

    Vrba, Lukas; Jensen, Taylor J.; Garbe, James C.; Heimark, Ronald L.; Cress, Anne E.; Dickinson, Sally; Stampfer, Martha R.; Futscher, Bernard W.

    2009-12-23

    BACKGROUND: The microRNA-200 family participates in the maintenance of an epithelial phenotype and loss of its expression can result in epithelial to mesenchymal transition (EMT). Furthermore, the loss of expression of miR-200 family members is linked to an aggressive cancer phenotype. Regulation of the miR-200 family expression in normal and cancer cells is not fully understood. METHODOLOGY/ PRINCIPAL FINDINGS: Epigenetic mechanisms participate in the control of miR-200c and miR-141 expression in both normal and cancer cells. A CpG island near the predicted mir-200c/mir-141 transcription start site shows a striking correlation between miR-200c and miR-141 expression and DNA methylation in both normal and cancer cells, as determined by MassARRAY technology. The CpG island is unmethylated in human miR-200/miR-141 expressing epithelial cells and in miR-200c/miR-141 positive tumor cells. The CpG island is heavily methylated in human miR-200c/miR-141 negative fibroblasts and miR-200c/miR-141 negative tumor cells. Mouse cells show a similar inverse correlation between DNA methylation and miR-200c expression. Enrichment of permissive histone modifications, H3 acetylation and H3K4 trimethylation, is seen in normal miR-200c/miR-141-positive epithelial cells, as determined by chromatin immunoprecipitation coupled to real-time PCR. In contrast, repressive H3K9 dimethylation marks are present in normal miR-200c/miR-141-negative fibroblasts and miR-200c/miR-141 negative cancer cells and the permissive histone modifications are absent. The epigenetic modifier drug, 5-aza-2'-deoxycytidine, reactivates miR-200c/miR-141 expression showing that epigenetic mechanisms play a functional role in their transcriptional control. CONCLUSIONS/ SIGNIFICANCE: We report that DNA methylation plays a role in the normal cell type-specific expression of miR-200c and miR-141 and this role appears evolutionarily conserved, since similar results were obtained in mouse. Aberrant DNA methylation of the

  14. Corrective Action Investigation Plan for the Central Nevada Test Area Subsurface Sites (Corrective Action Unit No. 443)

    SciTech Connect (OSTI)

    1998-02-01

    This Corrective Action Investigation Plan (CAIP) describes the U.S. Department of Energy`s (DOE`s) planned environmental investigation of the subsurface Central Nevada Test Area (CNTA) Corrective Action Unit (CAU) No. 443. The CNTA is located in Hot Creek Valley in Nye County, Nevada, adjacent to U.S. Highway 6, about 48 kilometers (km) (30 miles [mi]) north of Wann Springs, Nevada. The CNTA was the site of Project Faultless, a nuclear device detonated in the subsurface by the U.S. Atomic Energy Commission (AEC) in January 1968. The purposes of this test were to gauge the seismic effects of a relatively large, high-yield detonation completed in Hot Creek Valley (outside the Nevada Test Site) and to determine the suitability of the site for future large detonations. The yield of the Faultless test was between 200 kilotons and 1 megaton. Two similar tests were planned for the CNTA, but neither of them was completed (AEC, 1974).

  15. Fact #848: November 24, 2014 Nearly Three-Fourths of New Cars have Fuel Economy above 25 Miles per Gallon- Dataset

    Broader source: Energy.gov [DOE]

    Excel file with dataset for Fact #848: November 24, 2014 Nearly Three-Fourths of New Cars have Fuel Economy above 25 Miles per Gallon

  16. Fact #913: February 22, 2016 The Most Common Warranty for Plug-In Vehicle Batteries is 8 Years/100,000 Miles- Dataset

    Office of Energy Efficiency and Renewable Energy (EERE)

    Excel file and dataset for The Most Common Warranty for Plug-In Vehicle Batteries is 8 Years/100,000 Miles

  17. Fact #854 January 5, 2015 Driving Ranges for All-Electric Vehicles in Model Year 2014 Vary from 62 to 265 Miles – Dataset

    Broader source: Energy.gov [DOE]

    Excel file with dataset for Driving Ranges for All-Electric Vehicles in Model Year 2014 Vary from 62 to 265 Miles

  18. EA-1985: Virginia Offshore Wind Technology Advancement Project (VOWTAP), 24 nautical miles offshore of Virginia Beach, Virginia

    Broader source: Energy.gov [DOE]

    DOE is proposing to fund Virginia Electric and Power Company's Virginia Offshore Wind Technology Advancement Project (VOWTAP). The proposed VOWTAP project consists of design, construction and operation of a 12 megawatt offshore wind facility located approximately 24 nautical miles off the coast of Virginia Beach, VA on the Outer Continental Shelf.

  19. Evaluation of the Three Mile Island Unit 2 reactor building decontamination process

    SciTech Connect (OSTI)

    Dougherty, D.; Adams, J. W.

    1983-08-01

    Decontamination activities from the cleanup of the Three Mile Island Unit 2 Reactor Building are generating a variety of waste streams. Solid wastes being disposed of in commercial shallow land burial include trash and rubbish, ion-exchange resins (Epicor-II) and strippable coatings. The radwaste streams arising from cleanup activities currently under way are characterized and classified under the waste classification scheme of 10 CFR Part 61. It appears that much of the Epicor-II ion-exchange resin being disposed of in commerical land burial will be Class B and require stabilization if current radionuclide loading practices continue to be followed. Some of the trash and rubbish from the cleanup of the reactor building so far would be Class B. Strippable coatings being used at TMI-2 were tested for leachability of radionuclides and chelating agents, thermal stability, radiation stability, stability under immersion and biodegradability. Actual coating samples from reactor building decontamination testing were evaluated for radionuclide leaching and biodegradation.

  20. Historical summary of the Three Mile Island Unit 2 core debris transportation campaign

    SciTech Connect (OSTI)

    Schmitt, R.C.; Tyacke, M.J.; Quinn, G.J.

    1993-03-01

    Transport of the damaged core materials from the Unit 2 reactor of the Three Mile Island Nuclear Power Station (TMI-2) to the Idaho National Engineering Laboratory (INEL) for examination and storage presented many technical and institutional challenges, including assessing the ability to transport the damaged core; removing and packaging core debris in ways suitable for transport; developing a transport package that could both meet Federal regulations and interface with the facilities at TMI-2 and the INEL; and developing a transport plan, support logistics, and public communications channels suited to the task. This report is a historical summary of how the US Department of Energy addressed those challenges and transported, received, and stored the TMI-2 core debris at the INEL. Subjects discussed include preparations for transport, loading at TMI-2, institutional issues, transport operations, receipt and storage at the INEL, governmental inquiries/investigations, and lessons learned. Because of public attention focused on the TMI-2 Core Debris Transport Program, the exchange of information between the program and public was extensive. This exchange is a focus for parts of this report to explain why various operations were conducted as they were and why certain technical approaches were employed. And, because of that exchange, the program may have contributed to a better public understanding of such actions and may contribute to planning and execution of similar future actions.

  1. Lessons learned from the Three Mile Island Unit 2 Advisory Panel

    SciTech Connect (OSTI)

    Lach, D.; Bolton, P.; Durbin, N.; Harty, R.

    1994-08-01

    In response to public concern about the cleanup of the Three Mile Island, Unit 2 (TMI-2) facility after an accident on March 28, 1979 involving a loss of reactor coolant and subsequent damage to the reactor fuel, twelve citizens were asked to serve on an independent Advisory Panel to consult with the Nuclear Regulatory Commission (NRC) on the decontamination and cleanup of the facility. The panel met 78 times over a period of thirteen years, holding public meetings in the vicinity of TMI-2 and meeting regularly with NRC Commissioners in Washington, DC. This report describes the results of a project designed to identify and describe the lessons learned from the Advisory Panel and place those lessons in the context of what we generally know about citizen advisory groups. A summary of the empirical literature on citizen advisory panels is followed by a brief history of the TMI-2 Advisory Panel. The body of the report contains the analysis of the lessons learned, preliminary conclusions about the effectiveness of the Panel, and implications for the NRC in the use of advisory panels. Data for the report include meeting transcripts and interviews with past and present Panel participants.

  2. miR-92a family and their target genes in tumorigenesis and metastasis

    SciTech Connect (OSTI)

    Li, Molin; Guan, Xingfang; Sun, Yuqiang; Mi, Jun; Shu, Xiaohong; Liu, Fang; Li, Chuangang

    2014-04-15

    The miR-92a family, including miR-25, miR-92a-1, miR-92a-2 and miR-363, arises from three different paralog clusters miR-17-92, miR-106a-363, and miR-106b-25 that are highly conservative in the process of evolution, and it was thought as a group of microRNAs (miRNAs) correlated with endothelial cells. Aberrant expression of miR-92a family was detected in multiple cancers, and the disturbance of miR-92a family was related with tumorigenesis and tumor development. In this review, the progress on the relationship between miR-92a family and their target genes and malignant tumors will be summarized. - Highlights: Aberrant expression of miR-92a, miR-25 and miR-363 can be observed in many kinds of malignant tumors. The expression of miR-92a family is regulated by LOH, epigenetic alteration, transcriptional factors such as SP1, MYC, E2F, wild-type p53 etc. Roles of miR-92a family in tumorigenesis and development: promoting cell proliferation, invasion and metastasis, inhibiting cell apoptosis.

  3. Analysis of the Three Mile Island submerged demineralizer system vessel burial data

    SciTech Connect (OSTI)

    Jasen, W.G.; Amir, S.J.

    1989-09-01

    The Submerged Demineralizer System (SDS) was used during the Three Mile Island (TMI) nuclear reactor cleanup to remove cesium and strontium from contaminated water. The SDS vessels are 2-ft-in diameter and 4-ft tall stainless steel cylinders containing up to 60 kCi of radioactive cesium and strontium loaded on damp zeolite. The water in the damp zeolite absorbs some of the ionizing radiation and decomposes to hydrogen and oxygen by a process called radiolysis. Gas generation rates approaching 1 L/h (Quinn et al. 1984) have been calculated and measured for some of these loaded vessels. Each of the SDS vessels contains a catalyst bed to recombine the available hydrogen and oxygen back to water. Tests have proven this hydrogen control method to be highly effective, even under very wet (but unsubmerged) conditions. Nineteen SDS vessels, packaged one at a time in a shielded and licensed shipping cask, were shipped to Rockwell Hanford Operations (Rockwell). Collectively, these vessels contain approximately 7,500 kCi of radioactive material. Sixteen vessels were transloaded into concrete overpacks and buried at the Hanford Site. The contents of the other three vessels were vitrified at Pacific Northwest Laboratory. Subsequent to placement of the SDS vessels in the burial grounds, DOE Order 5820.2A (DOE 1988) was issued in September 1988. This order requires wastes to be evaluated against 10 CFR 61.55 for radioactivity above greater-than-class C(GTCC) limits. Fourteen of the sixteen vessels buried at the Hanford Site have been determined to be GTCC waste. 5 refs., 3 figs., 3 tabs.

  4. DOE - Office of Legacy Management -- Baker-Perkins Co - MI 13

    Office of Legacy Management (LM)

    Baker-Perkins Co - MI 13 FUSRAP Considered Sites Site: Baker-Perkins Co (MI 13) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Saginaw , Michigan MI.13-1 Evaluation Year: 1991 MI.13-1 MI.13-2 Site Operations: Small scale oxide mixing demonstrations and testing in May, 1956. MI.13-2 Site Disposition: Eliminated - Potential for contamination remote based on limited scope of activities at the site MI.13-3 Radioactive Materials Handled: Yes

  5. DOE - Office of Legacy Management -- Revere Copper and Brass Co - MI 04

    Office of Legacy Management (LM)

    Revere Copper and Brass Co - MI 04 FUSRAP Considered Sites Site: REVERE COPPER AND BRASS CO. ( MI.04 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: Revere Copper and Brass MI.04-1 Location: 5851 West Jefferson Street , Detroit , Michigan MI.04-1 Evaluation Year: 1990 MI.04-2 Site Operations: Extrusion of tuballoy rods, myrnalloy rods and beryllium shapes in the 1940s. MI.04-3 MI.04-4 Site Disposition: Eliminated - Radiation levels below criteria

  6. miR-17 inhibitor suppressed osteosarcoma tumor growth and metastasis via increasing PTEN expression

    SciTech Connect (OSTI)

    Gao, Yong; Luo, Ling-hui; Li, Shuai; Yang, Cao

    2014-02-07

    Highlights: • miR-17 was increased in OS tissues and cell lines. • Inhibition of miR-17 suppressed OS cell proliferation. • Inhibition of miR-17 suppressed OS cell migration and invasion. • PTEN was a target of miR-17. • miR-17 was negatively correlated with PTEN in OS tissues. - Abstract: MicroRNAs (miRNAs) play essential roles in cancer development and progression. Here, we investigated the role of miR-17 in the progression and metastasis of osteosarcoma (OS). miR-17 was frequently increased in OS tissues and cell lines. Inhibition of miR-17 in OS cell lines substantially suppressed cell proliferation, migration, and invasion. Phosphatase and tensin homolog (PTEN) was identified as a target of miR-17, and ectopic expression of miR-17 inhibited PTEN by direct binding to its 3′-untranslated region (3′-UTR). Expression of miR-17 was negatively correlated with PTEN in OS tissues. Together, these findings indicate that miR-17 acts as an oncogenic miRNA and may contribute to the progression and metastasis of OS, suggesting miR-17 as a potential novel diagnostic and therapeutic target of OS.

  7. Annual Radiological Environmental Monitoring Program Report for the Three Mile Island, Unit 2, Independent Spent Fuel Storage Installation

    SciTech Connect (OSTI)

    Hall, Gregory Graham

    2002-02-01

    This report presents the results of the 2001 Radiological Environmental Monitoring Program conducted in accordance with 10 CFR 72.44 for the Three Mile Island, Unit 2, Independent Spent Fuel Storage Installation. A description of the facility and the monitoring program is provided. The results of monitoring the two predominant radiation exposure pathways, potential airborne radioactivity releases and direct radiation exposure, indicate the facility operation has not contributed to any increase in the estimated maximum potential dose commitment to the general public.

  8. Annual Radiological Environmental Monitoring Program Report for the Three Mile Island, Unit 2, Independent Spent Fuel Storage Installation (2005)

    SciTech Connect (OSTI)

    Hall, Gregory Graham

    2001-02-01

    This report presents the results of the 2000 Radiological Environmental Monitoring Program conducted in accordance with 10 CFR 72.44 for the Three Mile Island, Unit 2, Independent Spent Fuel Storage Installation. A description of the facility and the monitoring program is provided. The results of monitoring the two predominant radiation exposure pathways, potential airborne radioactivity releases and direct radiation exposure, indicate the facility operation has not contributed to any increase in the estimated maximum potential dose commitment to the general public.

  9. Annual Radiological Environmental Monitoring Program Report for the Three Mile Island - Unit 2 Independent Spent Fuel Storage Installation

    SciTech Connect (OSTI)

    Gregory G. Hall

    2003-02-01

    This report presents the results of the 2002 Radiological Environmental Monitoring Program conducted in accordance with 10 CFR 72.44 for the Three Mile Island, Unit 2, Independent Spent Fuel Storage Installation. A description of the facility and the monitoring program is provided. The results of monitoring the two predominant radiation exposure pathways, potential airborne radioactivity releases and direct radiation exposure, indicate the facility operation has not contributed to any increase in the estimated maximum potential dose commitment to the general public.

  10. Annual Radiological Environmental Monitoring Program Report for the Three Mile Island, Unit 2, Independent Spent Fuel Storage Installation

    SciTech Connect (OSTI)

    Hall, Gregory Graham

    2001-02-01

    This report presents the results of the 2000 Radiological Environmental Monitoring Program conducted in accordance with 10 CFR 72.44 for the Three Mile Island, Unit 2, Independent Spent Fuel Storage Installation. A description of the facility and the monitoring program is provided. The results of monitoring the two predominant radiation exposure pathways, potential airborne radioactivity releases and direct radiation exposure, indicate the facility operation has not contributed to any increase in the estimated maximum potential dose commitment to the general public.

  11. Annual Radiological Environmental Monitoring Program Report for the Three Mile Island, Unit 2, Independent Spent Fuel Storage Installation

    SciTech Connect (OSTI)

    G. G. Hall

    2000-02-01

    This report presents the results of the 1999 Radiological Environmental Monitoring Program conducted in accordance with 10 CFR 72.44 for the Three Mile Island, Unit 2, Independent Spent Fuel Storage Installation. A description of the facility and the monitoring program is provided. The results of monitoring the two predominant radiation exposure pathways, potential airborne radioactivity releases and direct radiation exposure, indicate facility operation has not contributed to any increase in the estimated maximum potential dose commitment to the general public.

  12. Are We Forgetting the Lessons From the Accident at Three Mile Island Unit 2, March 1979: A Case Study

    SciTech Connect (OSTI)

    Christie, Bob; Johnson, David H.

    2002-07-01

    The accident at Three Mile Island Unit 2 in March 1979 resulted in major changes to the way emergency procedures were written and operators were trained at nuclear commercial electric generating units. These changes had a major impact on the public health risk of nuclear electric generating units. The record over the last 20 years has been excellent. For approximately 2000 reactor years of operation since 1979, there have been no accidents equivalent to TMI Unit 2 in the USA. Other factors have had an influence on this excellent record but it is clear that more efficient emergency procedures and better operator training had a significant impact on the excellent record achieved over the last 20 plus years. Abnormal events still occur at the nuclear commercial electric generating units in the USA and these events have the potential for causing damage to the reactor core. In some cases, the emergency procedures used in abnormal events and the training received by the operators of the nuclear units have not been based on the lessons learned from the accident at Three Mile Island. The following paper describes one such case. It is clear to the authors of this paper that further changes should be made to make sure that the lessons learned from the accident at Three Mile Island Unit 2 in 1979 are implemented and not forgotten. (authors)

  13. Area 6 Decontamination Pond Corrective Action Unit 92 Post-Closure Inspection Annual Report for the Period January 2000-December 2000

    SciTech Connect (OSTI)

    J. L. Traynor

    2001-03-01

    The Area 6 Decontamination Pond, Corrective Action Unit 92, was closed in accordance with the Resource Conservation and Recovery Act (RCRA) Part B Operational Permit (Nevada Division of Environmental Protection [NDEP, 1995]) and the Federal Facility Agreement and Consent Order (NDEP, 1996) on May 11, 1999. Historically the Decontamination Pond was used for the disposal of partially treated liquid effluent discharged from the Decontamination Facility (Building 6-05) and the Industrial Laundry (Building 6-07) (U.S. Department of Energy, Nevada Operations Office [DOE/NV], 1996). The Decontamination Pond was constructed and became operational in 1979. Releases of RCRA-regulated hazardous waste or hazardous waste constituents have not been discharged to the Decontamination Pond since 1988 (DOE/NV, 1996). The pipe connecting the Decontamination Pond and Decontamination Facility and Industrial Laundry were cut and sealed at the Decontamination Pad Oil/Water Separator in 1992. The Decontamination Pond was closed in place by installing a RCRA cover. Fencing was installed around the periphery to prevent accidental damage to the cover. Post-closure monitoring at the site consists of quarterly inspections of the RCRA cover and fencing, and a subsidence survey. Additional inspections are conducted if: Precipitation occurs in excess of 1.28 centimeters (cm) (0.50 inches [in]) in a 24-hour period, or An earthquake occurs with a magnitude exceeding 4.5 on the Richter scale within 100 kilometers (km) (62 miles [mi]) of the closure.

  14. Marysville, MI Natural Gas Exports to Canada

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    Monthly Annual Download Series History Download Series History Definitions, Sources & Notes Definitions, Sources & Notes Show Data By: Data Series Area 2009 2010 2011 2012 2013...

  15. MiR-218 Mediates tumorigenesis and metastasis: Perspectives and implications

    SciTech Connect (OSTI)

    Lu, Ying-fei; Zhang, Li; Waye, Mary Miu Yee; Fu, Wei-ming; Zhang, Jin-fang

    2015-05-15

    MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. As a highly conserved miRNA across a variety of species, microRNA-218 (miR-218) was found to play pivotal roles in tumorigenesis and progression. A group of evidence has demonstrated that miR-218 acts as a tumor suppressor by targeting many oncogenes related to proliferation, apoptosis and invasion. In this review, we provide a complex overview of miR-218, including its regulatory mechanisms, known functions in cancer and future challenges as a potential therapeutic target in human cancers. - Highlights: • miR-218 is frequently down regulated in multiple cancers. • miR-218 plays pivotal roles in carcinogenesis. • miR-218 mediates proliferation, apoptosis, metastasis, invasion, etc. • miR-218 mediates tumorigenesis and metastasis via multiple pathways.

  16. DOE - Office of Legacy Management -- Dow-Detroit Edison Project - MI 0-02

    Office of Legacy Management (LM)

    Dow-Detroit Edison Project - MI 0-02 FUSRAP Considered Sites Site: Dow-Detroit Edison Project (MI.0-02 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Detroit , Michigan MI.0-02-1 Evaluation Year: 1987 MI.0-02-1 Site Operations: Performed reference design work for a special fast breeder type reactor. MI.0-02-1 Site Disposition: Eliminated - No radioactive material handled at the site MI.0-02-1 Radioactive Materials Handled: No

  17. DOE - Office of Legacy Management -- Mitts-Merrill Co - MI 14

    Office of Legacy Management (LM)

    Mitts-Merrill Co - MI 14 FUSRAP Considered Sites Site: MITTS and MERRILL CO. (MI.14 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: Genessee Packing Co. MI.14-1 Location: Saginaw, Michigan MI.14-1 Evaluation Year: 1993 MI.14-2 Site Operations: Reduced thorium metal chunks into particle sized pieces on a small test scale during the mid-1950s. MI.14-1 Site Disposition: Eliminated - Potential for contamination considered remote based on limited quantity

  18. Corrective Action Decision Document/Closure Report for Corrective Action Unit 551: Area 12 Muckpiles, Nevada Test Site, Nevada, Rev. No.: 1

    SciTech Connect (OSTI)

    Wickline, Alfred

    2006-11-01

    This Corrective Action Decision Document (CADD)/Closure Report (CR) presents information supporting closure of Corrective Action Unit (CAU) 551, Area 12 Muckpiles, Nevada Test Site (NTS), Nevada. The corrective actions proposed in this document are in accordance with the Federal Facility Agreement and Consent Order (FFACO) that was agreed to by the State of Nevada, U.S. Department of Energy (DOE), and the U.S. Department of Defense (FFACO, 1996). The NTS is approximately 65 miles (mi) northwest of Las Vegas, Nevada (Figure 1-1). Corrective Action Unit 551 is comprised of the four Corrective Action Sites (CASs) that are shown on Figure 1-2 and listed below: CAS 12-01-09, Aboveground Storage Tank and Stain; CAS 12-06-05, U-12b Muckpile; CAS 12-06-07, Muckpile; and CAS 12-06-08, Muckpile. A detailed discussion of the history of this CAU is presented in the ''Corrective Action Investigation Plan (CAIP) for Corrective Action Unit 551: Area 12 Muckpiles'' (NNSA/NSO, 2004). This CADD/CR provides justification for the closure of CAU 551 in place with administrative controls. This justification is based upon process knowledge and the results of the investigative activities conducted in accordance with the CAIP (NNSA/NSO, 2004). The CAIP provides information relating to the history, planning, and scope of the investigation; therefore, this information will not be repeated in the CADD/CR. Corrective Action Unit 551, Area 12 Muckpiles, consists of four inactive sites located in the southwestern portion of Area 12. The four CAU 551 sites consist of three muckpiles, and an aboveground storage tank (AST) and stain. The CAU 551 sites were all used during underground nuclear testing at the B-, C-, D- and F-Tunnels in the late 1950s and early 1960s and have mostly remained inactive since that period.

  19. miRNA-205 affects infiltration and metastasis of breast cancer

    SciTech Connect (OSTI)

    Wang, Zhouquan; Department of Tumor, SenGong Hospital of Shaanxi, Xian 710300 ; Liao, Hehe; Deng, Zhiping; Yang, Po; Du, Ning; Zhanng, Yunfeng; Ren, Hong

    2013-11-08

    Highlights: We detected expression of miR-205 in breast cancer cell lines and tissue samples. We suggest miR-205 is downregulated in human breast cancer tissues and MCF7 cells. We suggest the lower expression of miR-205 play a role in breast cancer onset. These data suggest that miR-205 directly targets HER3 in human breast cancer. -- Abstract: Background: An increasing number of studies have shown that miRNAs are commonly deregulated in human malignancies, but little is known about the function of miRNA-205 (miR-205) in human breast cancer. The present study investigated the influence of miR-205 on breast cancer malignancy. Methods: The expression level of miR-205 in the MCF7 breast cancer cell line was determined by quantitative (q)RT-PCR. We then analyzed the expression of miR-205 in breast cancer and paired non-tumor tissues. Finally, the roles of miR-205 in regulating tumor proliferation, apoptosis, migration, and target gene expression were studied by MTT assay, flow cytometry, qRT-PCR, Western blotting and luciferase assay. Results: miR-205 was downregulated in breast cancer cells or tissues compared with normal breast cell lines or non-tumor tissues. Overexpression of miR-205 reduced the growth and colony-formation capacity of MCF7 cells by inducing apoptosis. Overexpression of miR-205 inhibited MCF7 cell migration and invasiveness. By bioinformation analysis, miR-205 was predicted to bind to the 3? untranslated regions of human epidermal growth factor receptor (HER)3 mRNA, and upregulation of miR-205 reduced HER3 protein expression. Conclusion: miR-205 is a tumor suppressor in human breast cancer by post-transcriptional inhibition of HER3 expression.

  20. Review of Destructive Assay Methods for Nuclear Materials Characterization from the Three Mile Island (TMI) Fuel Debris

    SciTech Connect (OSTI)

    Carla J. Miller

    2013-09-01

    This report provides a summary of the literature review that was performed and based on previous work performed at the Idaho National Laboratory studying the Three Mile Island 2 (TMI-2) nuclear reactor accident, specifically the melted fuel debris. The purpose of the literature review was to document prior published work that supports the feasibility of the analytical techniques that were developed to provide quantitative results of the make-up of the fuel and reactor component debris located inside and outside the containment. The quantitative analysis provides a technique to perform nuclear fuel accountancy measurements

  1. NuMI Low Energy Flux Prediction Release

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NuMI Low Energy Flux Prediction Release Neutrino Flux Predictions for the NuMI Beam hep-ex/1607.00704 Data Ancillary data files for this result are available on arXiv at http://arxiv.org/src/1607.00704/anc.< /li> Among the available data files are: pdf file describing format of all the available files root file of all the available fluxes python code to read and process MINERvA's flux predictions Text Files of the flux, uncertainties, and covariance matrix, with units of neutrinos/m^2/POT,

  2. Port Huron, MI Liquefied Natural Gas Exports (Million Cubic Feet)

    U.S. Energy Information Administration (EIA) Indexed Site

    (Million Cubic Feet) Port Huron, MI Liquefied Natural Gas Exports (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2013 1 2014 1 1 1 1 2 1 1 1 1 1 2015 1 1 1 1 1 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 08/31/2016 Next Release Date: 09/30/2016 Referring Pages: U.S. Liquefied Natural Gas Exports by Point of Exit Port Huron, MI LNG Exports to All Countries

  3. Ground Motion Studies at NuMI

    SciTech Connect (OSTI)

    Mayda M. Velasco; Michal Szleper

    2012-02-20

    Ground motion can cause significant deterioration in the luminosity of a linear collider. Vibration of numerous focusing magnets causes continuous misalignments, which makes the beam emittance grow. For this reason, understanding the seismic vibration of all potential LC sites is essential and related efforts in many sites are ongoing. In this document we summarize the results from the studies specific to Fermilab grounds as requested by the LC project leader at FNAL, Shekhar Mishra in FY04-FY06. The Northwestern group focused on how the ground motion effects vary with depth. Knowledge of depth dependence of the seismic activity is needed in order to decide how deep the LC tunnel should be at sites like Fermilab. The measurements were made in the NuMI tunnel, see Figure 1. We take advantage of the fact that from the beginning to the end of the tunnel there is a height difference of about 350 ft and that there are about five different types of dolomite layers. The support received allowed to pay for three months of salary of Michal Szleper. During this period he worked a 100% of his time in this project. That include one week of preparation: 2.5 months of data taking and data analysis during the full period of the project in order to guarantee that we were recording high quality data. We extended our previous work and made more systematic measurements, which included detailed studies on stability of the vibration amplitudes at different depths over long periods of time. As a consequence, a better control and more efficient averaging out of the daytime variation effects were possible, and a better study of other time dependences before the actual depth dependence was obtained. Those initial measurements were made at the surface and are summarized in Figure 2. All measurements are made with equipment that we already had (two broadband seismometers KS200 from GEOTECH and DL-24 portable data recorder). The offline data analysis took advantage of the full Fourier spectra

  4. DOE - Office of Legacy Management -- Mitts-Merrel Co - MI 14

    Office of Legacy Management (LM)

    1993 MI.14-2 Site Operations: Reduced thorium metal chunks into particle sized pieces ... Primary Radioactive Materials Handled: Thorium MI.14-1 Radiological Survey(s): Yes - ...

  5. DOE - Office of Legacy Management -- Amex Specialty Metal Corp - MI 0-01

    Office of Legacy Management (LM)

    Amex Specialty Metal Corp - MI 0-01 FUSRAP Considered Sites Site: Amex Specialty Metal Corp (MI.0-01 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Coldwater , Michigan MI.0-01-1 Evaluation Year: 1987 MI.0-01-1 Site Operations: No indication that AMEX performed work for MED or AEC activities. Originally included on FUSRAP list due to fact that AMEX purchased milling equipment from a company that had done uranium milling.

  6. MiR-125a TNF receptor-associated factor 6 to inhibit osteoclastogenesis

    SciTech Connect (OSTI)

    Guo, Li-Juan; Liao, Lan; Yang, Li; Li, Yu; Jiang, Tie-Jian

    2014-02-15

    MicroRNAs (miRNAs) play important roles in osteoclastogenesis and bone resorption. In the present study, we found that miR-125a was dramatically down-regulated during macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL) induced osteoclastogenesis of circulating CD14+ peripheral blood mononuclear cells (PBMCs). Overexpression of miR-125a in CD14+ PBMCs inhibited osteoclastogenesis, while inhibition of miR-125a promoted osteoclastogenesis. TNF receptor-associated factor 6 (TRAF6), a transduction factor for RANKL/RANK/NFATc1 signal, was confirmed to be a target of miR-125a. EMSA and ChIP assays confirmed that NFATc1 bound to the promoter of the miR-125a. Overexpression of NFATc1 inhibited miR-125a transcription, and block of NFATc1 expression attenuated RANKL-regulated miR-125a transcription. Here, we reported that miR-125a played a biological function in osteoclastogenesis through a novel TRAF6/ NFATc1/miR-125a regulatory feedback loop. It suggests that regulation of miR-125a expression may be a potential strategy for ameliorating metabolic disease. - Highlights: • MiR-125a was significantly down-regulated in osteoclastogenesis of CD14+ PBMCs. • MiR-125a inhibited osteoclast differentiation by targeting TRAF6. • NFATc1 inhibited miR-125a transciption by binding to the promoter of miR-125a. • TRAF6/NFATc1 and miR-125a form a regulatory feedback loop in osteoclastogenesis.

  7. MiR-145 functions as a tumor suppressor targeting NUAK1 in human intrahepatic cholangiocarcinoma

    SciTech Connect (OSTI)

    Xiong, Xinkui; Sun, Daoyi; Chai, Hao; Shan, Wengang; Yu, Yue; Pu, Liyong; Cheng, Feng

    2015-09-18

    The dysregulation of micro (mi)RNAs is associated with cancer development. The miRNA miR-145 is downregulated in intrahepatic cholangiocarcinoma (ICC); however, its precise role in tumor progression has not yet been elucidated. Novel (nua) kinase family (NUAK)1 functions as an oncogene in various cancers and is a putative target of miR-145 regulation. In this study, we investigated the regulation of NUAK1 by miR-145 in ICC. We found that miR-145 level was significantly decreased in ICC tissue and cell lines, which corresponded with an increase in NUAK1 expression. NUAK1 was found to be a direct target of miR-145 regulation. The overexpression of miR-145 in ICC cell lines inhibited proliferation, growth, and invasion by suppressing NUAK1 expression, which was associated with a decrease in Akt signaling and matrix metalloproteinase protein expression. Similar results were observed by inhibiting NUAK1 expression. These results demonstrate that miR-145 can prevent ICC progression by targeting NUAK1 and its downstream effectors, and can therefore be useful for clinical diagnosis and targeted therapy of ICC. - Highlights: • MiR-145 suppresses ICC proliferation and invasion abilities. • We demonstrated that miR-145 directly targets NUAK1 in ICC. • MiR-145 expression in ICC was associated with Akt signaling and MMPs expression.

  8. Neutron scattering study of spin ordering and stripe pinning in superconducting <mi>La>1.93<mi>Sr>0.07<mi>CuO>4

    SciTech Connect (OSTI)

    Jacobsen, H.; Zaliznyak, I. A.; Savici, A. T.; Winn, B. L.; Chang, S.; Hücker, M.; Gu, G. D.; Tranquada, J. M.

    2015-11-20

    The relationships among charge order, spin fluctuations, and superconductivity in underdoped cuprates remain controversial. We use neutron scattering techniques to study these phenomena in <mi>La>1.93<mi>Sr>0.07<mi>CuO>4 a superconductor with a transition temperature of Tc = 20 K. At T<< Tc, we find incommensurate spin fluctuations with a quasielastic energy spectrum and no sign of a gap within the energy range from 0.2 to 15 meV. A weak elastic magnetic component grows below ~ 10 K, consistent with results from local probes. Regarding the atomic lattice, we have discovered unexpectedly strong fluctuations of the CuO6 octahedra about Cu-O bonds, which are associated with inequivalent O sites within the CuO2 planes. Moreover, we observed a weak elastic (3 30) superlattice peak that implies a reduced lattice symmetry. The presence of inequivalent O sites rationalizes various pieces of evidence for charge stripe order in underdoped La2-xSrxCuO4. The coexistence of superconductivity with quasi-static spin-stripe order suggests the presence of intertwined orders; however, the rotation of the stripe orientation away from the Cu-O bonds might be connected with evidence for a finite gap at the nodal points of the superconducting gap function.

  9. Radiosensitizing Effects of Ectopic miR-101 on Non-Small-Cell Lung Cancer Cells Depend on the Endogenous miR-101 Level

    SciTech Connect (OSTI)

    Chen, Susie; Wang Hongyan; Ng, Wooi Loon; Curran, Walter J.; Wang Ya

    2011-12-01

    Purpose: Previously, we showed that ectopic miR-101 could sensitize human tumor cells to radiation by targeting ATM and DNA-PK catalytic subunit (DNA-PKcs) to inhibit DNA repair, as the endogenous miR-101 levels are low in tumors in general. However, the heterogeneity of human cancers may result in an exception. The purpose of this study was to test the hypothesis that a few tumor cell lines with a high level of endogenous miR-101 would prove less response to ectopic miR-101. Methods and Materials: Fourteeen non-small-cell lung cancer (NSCLC) cell lines and one immortalized non-malignant lung epithelial cell line (NL20) were used for comparing endogenous miR-101 levels by real-time reverse transcription-polymerase chain reaction. Based on the different miR-101 levels, four cell lines with different miR-101 levels were chosen for transfection with a green fluorescent protein-lentiviral plasmid encoding miR-101. The target protein levels were measured by using Western blotting. The radiosensitizing effects of ectopic miR-101 on these NSCLC cell lines were determined by a clonogenic assay and xenograft mouse model. Results: The endogenous miR-101 level was similar or lower in 13 NSCLC cell lines but was 11-fold higher in one cell line (H157) than in NL20 cells. Although ectopic miR-101 efficiently decreased the ATM and DNA-PKcs levels and increased the radiosensitization level in H1299, H1975, and A549 cells, it did not change the levels of the miR-101 targets or radiosensitivity in H157 cells. Similar results were observed in xenograft mice. Conclusions: A small number of NSCLC cell lines could have a high level of endogenous miR-101. The ectopic miR-101 was able to radiosensitize most NSCLC cells, except for the NSCLC cell lines that had a much higher endogenous miR-101 level. These results suggest that when we choose one miRNA as a therapeutic tool, the endogenous level of the miRNA in each tumor should be considered.

  10. Corrective Action Decision Document/Closure Report for Corrective Action Unit 309: Area 12 Muckpiles, Nevada Test Site, Nevada, Rev. No.: 0 with Errata Sheet

    SciTech Connect (OSTI)

    Alfred Wickline

    2005-12-01

    This Corrective Action Decision Document/Closure Report (CADD/CR) has been prepared for Corrective Action Unit (CAU) 309, Area 12 Muckpiles, Nevada Test Site (NTS), Nevada. The corrective actions proposed in this document are according to the ''Federal Facility Agreement and Consent Order'' (FFACO) that was agreed to by the State of Nevada, U.S. Department of Energy (DOE), and the U.S. Department of Defense (FFACO, 1996). The NTS is approximately 65 miles (mi) northwest of Las Vegas, Nevada (Figure 1-1). Corrective Action Unit 309 is comprised of the three Corrective Action Sites (CASs) (Figure 1-1) listed below: (1) CAS 12-06-09, Muckpile; (2) CAS 12-08-02, Contaminated Waste Dump (CWD); and (3) CAS 12-28-01, I-, J-, and K-Tunnel Debris. Corrective Action Sites 12-06-09 and 12-08-02 will be collectively referred to as muckpiles in this document. Corrective Action Site 12-28-01 will be referred to as the fallout plume because of the extensive lateral area of debris and fallout contamination resulting from the containment failures of the J- and K-Tunnels. A detailed discussion of the history of this CAU is presented in the ''Corrective Action Investigation Plan (CAIP) for Corrective Action Unit 309: Area 12 Muckpiles, Nevada Test Site (NTS), Nevada.'' (NNSA/NSO, 2004). This CADD/CR provides justification for the closure of CAU 309 without further corrective action. This justification is based on process knowledge and the results of the investigative activities conducted according to the CAIP (NNSA/NSO, 2004), which provides information relating to the history, planning, and scope of the investigation. Therefore, this information will not be repeated in this CADD/CR.

  11. Geothermal resource assessment of Canon City, Colorado Area

    SciTech Connect (OSTI)

    Zacharakis, Ted G.; Pearl, Richard Howard

    1982-01-01

    In 1979 a program was initiated to fully define the geothermal conditions of an area east of Canon City, bounded by the mountains on the north and west, the Arkansas River on the south and Colorado Highway 115 on the east. Within this area are a number of thermal springs and wells in two distinct groups. The eastern group consists of 5 thermal artesian wells located within one mile of Colorado Highway 115 from Penrose on the north to the Arkansas river on the south. The western group, located in and adjacent to Canon City, consists of one thermal spring on the south bank of the Arkansas River on the west side of Canon City, a thermal well in the northeast corner of Canon City, another well along the banks of Four Mile Creek east of Canon City and a well north of Canon City on Four Mile Creek. All the thermal waters in the Canon City Embayment, of which the study area is part of, are found in the study area. The thermal waters unlike the cold ground waters of the Canon City Embayment, are a calcium-bicarbonate type and range in temperature from 79 F (26 C) to a high of 108 F (42 C). The total combined surface discharge o fall the thermal water in the study area is in excess of 532 acre feet (A.F.) per year.

  12. Transporting TMI-2 (Three Mile Island Unit 2) core debris to INEL: Public safety and public response

    SciTech Connect (OSTI)

    Schmitt, R.C.; Reno, H.W.; Young, W.R.; Hamric, J.P.

    1987-01-01

    This paper describes the approach taken by the US Department of Energy (DOE) to ensure that public safety is maintained during transport of core debris from the Unit-2 reactor at the Three Mile Island Nuclear Power Station near Harrisburg, PA, to the Idaho National Engineering Laboratory near Idaho Falls, ID. It provides up-to-date information about public response to the transport action and discusses DOE's position on several institutional issues. The authors advise that planners of future transport operations be prepared for a multitude of comments from all levels of federal, state, and local governments, special interest groups, and private citizens. They also advise planners to keep meticulous records concerning all informational transactions.

  13. Disposal demonstration of a high integrity container (HIC) containing an EPICOR-II prefilter from Three Mile Island

    SciTech Connect (OSTI)

    McConnell, J.W. Jr.; Tyacke, M.J.; Schmitt, R.C.; Reno, H.W.

    1985-02-01

    A high integrity container (HIC) was developed, tested, and certified for use in disposing of unusual low-level radioactive waste from Three Mile Island Unit 2 (TMI-2). The work was coordinated by EG and G Idaho, Inc. and funded by the US Department of Energy. A disposal demonstration using an HIC containing an EPICOR-II prefilter from TMI-2 was completed at the commercial disposal facility in the State of Washington. A Certification of Compliance was issued by the Department of Social and Health Services of the State of Washington to use the HIC in disposing of up to 50 EPICOR-II prefilters. That Certification of Compliance was issued after rigorous review of the HIC design and test program by the State and by the US Nuclear Regulatory Commission. This report describes the processes of loading, transporting, and disposing of the demonstration HIC and briefly describes the design, testing, and approval effort leading up to the demonstration.

  14. Transformer failure and common-mode loss of instrument power at Nine Mile Point Unit 2 on August 13, 1991

    SciTech Connect (OSTI)

    Not Available

    1991-10-01

    On August 13, 1991, at Nine Mile Point Unit 2 nuclear power plant, located near Scriba, New York, on Lake Ontario, the main transformer experienced an internal failure that resulted in degraded voltage which caused the simultaneous loss of five uninterruptible power supplies, which in turn caused the loss of several nonsafety systems, including reactor control rod position indication, some reactor power and water indication, control room annunciators, the plant communications system, the plant process computer, and lighting at some locations. The reactor was subsequently brought to a safe shutdown. Following this event, the US Nuclear Regulatory Commission dispatched an Incident Investigation Team to the site to determine what happened, to identify the probable causes, and to make appropriate findings and conclusions. This report describes the incident, the methodology used by the team in its investigation, and presents and the team's findings and conclusions. 59 figs., 14 tabs.

  15. Evaluation of nuclear facility decommissioning projects: Summary status report: Three Mile Island Unit 2. Radioactive waste and laundry shipments

    SciTech Connect (OSTI)

    Doerge, D. H.; Haffner, D. R.

    1988-06-01

    This document summarizes information concerning radioactive waste and laundry shipments from the Three Mile Island Nuclear Station Unit 2 to radioactive waste disposal sites and to protective clothing decontamination facilities (laundries) since the loss of coolant accident experienced on March 28, 1979. Data were collected from radioactive shipment records, summarized, and placed in a computerized data information retrieval/manipulation system which permits extraction of specific information. This report covers the period of April 9, 1979 through April 19, 1987. Included in this report are: waste disposal site locations, dose rates, curie content, waste description, container type and number, volumes and weights. This information is presented in two major categories: protective clothing (laundry) and radioactive waste. Each of the waste shipment reports is in chronological order.

  16. Research Areas

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research Areas Our Vision National User Facilities Research Areas In Focus Global Solutions ⇒ Navigate Section Our Vision National User Facilities Research Areas In Focus Global Solutions Biosciences The Biosciences Area forges multidisciplinary teams to solve national challenges in energy, environment and health issues; and to advance the engineering of biological systems for sustainable manufacturing. Biosciences Area research is coordinated through three divisions and is enabled by Berkeley

  17. Fact #854 January 5, 2015 Driving Ranges for All-Electric Vehicles in Model Year 2014 Vary from 62 to 265 Miles

    Broader source: Energy.gov [DOE]

    Driving ranges for all-electric vehicles vary considerably. Based on the official Environmental Protection Agency (EPA) range values reported on window stickers, the Mitsubishi i-MiEV has the...

  18. NNSA to conduct Aerial Radiation Assessment Survey over Boston area |

    National Nuclear Security Administration (NNSA)

    National Nuclear Security Administration | (NNSA) Boston area March 31, 2015 BOSTON- A helicopter may be seen flying at low altitudes around Boston from April 6 - 15, 2015. The purpose of the flyovers is to measure naturally occurring background radiation. Officials from U.S. Department of Energy's National Nuclear Security Administration (NNSA) announced that the radiation assessment will cover approximately 25 square miles. A twin-engine Bell 412 helicopter, operated by the Remote Sensing

  19. NNSA to conduct Aerial Radiation Assessment Survey over Boston area |

    National Nuclear Security Administration (NNSA)

    National Nuclear Security Administration | (NNSA) conduct Aerial Radiation Assessment Survey over Boston area April 11, 2016 BOSTON - On April 12 through April 15, the U.S. Department of Energy's National Nuclear Security Administration's (NNSA) will conduct low-altitude helicopter flights around Boston to measure naturally occurring background radiation. Officials from NNSA announced that the radiation assessment will cover approximately 13 square miles. A twin-engine Bell 412 helicopter,

  20. Executive summary of major NuMI lessons learned: a review of relevant meetings of Fermilab's DUSEL Beamline Working Group

    SciTech Connect (OSTI)

    Andrews, Mike; Appel, Jeffrey A.; Bogert, Dixon; Childress, Sam; Cossairt, Don; Griffing, William; Grossman, Nancy; Harding, David; Hylen, Jim; Kuchler, Vic; Laughton, Chris; /Fermilab /Argonne /Brookhaven /LBL, Berkeley

    2009-05-01

    We have gained tremendous experience with the NuMI Project on what was a new level of neutrino beams from a high power proton source. We expect to build on that experience for any new long baseline neutrino beam. In particular, we have learned about some things which have worked well and/or where the experience is fairly directly applicable to the next project (e.g., similar civil construction issues including: tunneling, service buildings, outfitting, and potential claims/legal issues). Some things might be done very differently (e.g., decay pipe, windows, target, beam dump, and precision of power supply control/monitoring). The NuMI experience does lead to identification of critical items for any future such project, and what issues it will be important to address. The DUSEL Beamline Working Group established at Fermilab has been meeting weekly to collect and discuss information from that NuMI experience. This document attempts to assemble much of that information in one place. In this Executive Summary, we group relevant discussion of some of the major issues and lessons learned under seven categories: (1) Differences Between the NuMI Project and Any Next Project; (2) The Process of Starting Up the Project; (3) Decision and Review Processes; (4) ES&H: Environment, Safety, and Health; (5) Local Community Buy-In; (6) Transition from Project Status to Operation; and (7) Some Lessons on Technical Elements. We concentrate here on internal project management issues, including technical areas that require special attention. We cannot ignore, however, two major external management problems that plagued the NuMI project. The first problem was the top-down imposition of an unrealistic combination of scope, cost, and schedule. This situation was partially corrected by a rebaselining. However, the full, desirable scope was never achievable. The second problem was a crippling shortage of resources. Critical early design work could not be done in a timely fashion, leading to

  1. DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1

    SciTech Connect (OSTI)

    Lerner, Mikael; Harada, Masako; Loven, Jakob; Castro, Juan; Davis, Zadie; Oscier, David; Henriksson, Marie; Sangfelt, Olle; Grander, Dan; Corcoran, Martin M.

    2009-10-15

    The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. Despite their abundance in most cells the transcriptional regulation of miR-15a/16-1 remains unclear. Here we demonstrate that the putative tumor suppressor DLEU2 acts as a host gene of these microRNAs. Mature miR-15a/miR-16-1 are produced in a Drosha-dependent process from DLEU2 and binding of the Myc oncoprotein to two alterative DLEU2 promoters represses both the host gene transcript and levels of mature miR-15a/miR-16-1. In line with a functional role for DLEU2 in the expression of the microRNAs, the miR-15a/miR-16-1 locus is retained in four CLL cases that delete both promoters of this gene and expression analysis indicates that this leads to functional loss of mature miR-15a/16-1. We additionally show that DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1 and provide evidence that these oncoproteins are subject to miR-15a/miR-16-1-mediated repression under normal conditions. We also demonstrate that DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way. Together the data illuminate how inactivation of DLEU2 promotes cell proliferation and tumor progression through functional loss of miR-15a/miR-16-1.

  2. Corrective Action Plan for Corrective Action Unit 262: Area 25 Septic Systems and Underground Discharge Point, Nevada Test Site, Nevada

    SciTech Connect (OSTI)

    K. B. Campbell

    2002-06-01

    This Corrective Action Plan (CAP) provides selected corrective action alternatives and proposes the closure methodology for Corrective Action Unit (CAU) 262, Area 25 Septic Systems and Underground Discharge Point. CAU 262 is identified in the Federal Facility Agreement and Consent Order (FFACO) of 1996. Remediation of CAU 262 is required under the FFACO. CAU 262 is located in Area 25 of the Nevada Test Site (NTS), approximately 100 kilometers (km) (62 miles [mi]) northwest of Las Vegas, Nevada. The nine Corrective Action Sites (CASs) within CAU 262 are located in the Nuclear Rocket Development Station complex. Individual CASs are located in the vicinity of the Reactor Maintenance, Assembly, and Disassembly (R-MAD); Engine Maintenance, Assembly, and Disassembly (E-MAD); and Test Cell C compounds. CAU 262 includes the following CASs as provided in the FFACO (1996); CAS 25-02-06, Underground Storage Tank; CAS 25-04-06, Septic Systems A and B; CAS 25-04-07, Septic System; CAS 25-05-03, Leachfield; CAS 25-05-05, Leachfield; CAS 25-05-06, Leachfield; CAS 25-05-08, Radioactive Leachfield; CAS 25-05-12, Leachfield; and CAS 25-51-01, Dry Well. Figures 2, 3, and 4 show the locations of the R-MAD, the E-MAD, and the Test Cell C CASs, respectively. The facilities within CAU 262 supported nuclear rocket reactor engine testing. Activities associated with the program were performed between 1958 and 1973. However, several other projects used the facilities after 1973. A significant quantity of radioactive and sanitary waste was produced during routine operations. Most of the radioactive waste was managed by disposal in the posted leachfields. Sanitary wastes were disposed in sanitary leachfields. Septic tanks, present at sanitary leachfields (i.e., CAS 25-02-06,2504-06 [Septic Systems A and B], 25-04-07, 25-05-05,25-05-12) allowed solids to settle out of suspension prior to entering the leachfield. Posted leachfields do not contain septic tanks. All CASs located in CAU 262 are

  3. Research Areas

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in diverse research areas such as cell biology, lithography, infrared microscopy, radiology, and x-ray tomography. Time-Resolved These techniques exploit the pulsed nature of...

  4. Bay Area

    National Nuclear Security Administration (NNSA)

    8%2A en NNSA to Conduct Aerial Radiological Surveys Over San Francisco, Pacifica, Berkeley, And Oakland, CA Areas http:nnsa.energy.govmediaroompressreleasesamsca

  5. Genome-Wide Analysis of miRNA targets in Brachypodium and Biomass Energy Crops

    SciTech Connect (OSTI)

    Green, Pamela J.

    2015-08-11

    MicroRNAs (miRNAs) contribute to the control of numerous biological processes through the regulation of specific target mRNAs. Although the identities of these targets are essential to elucidate miRNA function, the targets are much more difficult to identify than the small RNAs themselves. Before this work, we pioneered the genome-wide identification of the targets of Arabidopsis miRNAs using an approach called PARE (German et al., Nature Biotech. 2008; Nature Protocols, 2009). Under this project, we applied PARE to Brachypodium distachyon (Brachypodium), a model plant in the Poaceae family, which includes the major food grain and bioenergy crops. Through in-depth global analysis and examination of specific examples, this research greatly expanded our knowledge of miRNAs and target RNAs of Brachypodium. New regulation in response to environmental stress or tissue type was found, and many new miRNAs were discovered. More than 260 targets of new and known miRNAs with PARE sequences at the precise sites of miRNA-guided cleavage were identified and characterized. Combining PARE data with the small RNA data also identified the miRNAs responsible for initiating approximately 500 phased loci, including one of the novel miRNAs. PARE analysis also revealed that differentially expressed miRNAs in the same family guide specific target RNA cleavage in a correspondingly tissue-preferential manner. The project included generation of small RNA and PARE resources for bioenergy crops, to facilitate ongoing discovery of conserved miRNA-target RNA regulation. By associating specific miRNA-target RNA pairs with known physiological functions, the research provides insights about gene regulation in different tissues and in response to environmental stress. This, and release of new PARE and small RNA data sets should contribute basic knowledge to enhance breeding and may suggest new strategies for improvement of biomass energy crops.

  6. Percolation Cooling of the Three Mile Island Unit 2 Lower Head by Way of Thermal Cracking and Gap Formation

    SciTech Connect (OSTI)

    Thomsen, K.L.

    2002-01-15

    Two partial models have been developed to elucidate the Three Mile Island Unit 2 lower head coolability by water percolation from above into the thermally cracking debris bed and into a gap between the debris and the wall. The bulk permeability of the cracked top crust is estimated based on simple fracture mechanics and application of Poiseuille's law to the fractures. The gap is considered as an abstraction representing an initially rugged interface, which probably expanded by thermal deformation and cracking in connection with the water ingress. The coupled flow and heat conduction problem for the top crust is solved in slab geometry based on the two-phase Darcy equations together with quasi-steady mass and energy conservation equations. The resulting water penetration depth is in good agreement with the depth of the so-called loose debris bed. The lower-head and bottom-crust problem is treated analogously by a two-dimensional axisymmetric model. The notion of a gap is maintained as a useful concept in the flow analysis. Simulations show that a central hot spot with a peak wall temperature of 1075 to 1100 deg. C can be obtained, but the quenching rates are not satisfactory. It is concluded that a three-dimensional model with an additional mechanism to explain the sudden water ingress to the hot spot center would be more appropriate.

  7. miR-4295 promotes cell proliferation and invasion in anaplastic thyroid carcinoma via CDKN1A

    SciTech Connect (OSTI)

    Shao, Mingchen; Geng, Yiwei; Lu, Peng; Xi, Ying; Wei, Sidong; Wang, Liuxing; Fan, Qingxia; Ma, Wang

    2015-09-04

    MicroRNAs (miRNAs) play important roles in the pathogenesis of many types of cancers by negatively regulating gene expression at posttranscriptional level. However, the role of microRNAs in anaplastic thyroid carcinoma (ATC), has remained elusive. Here, we identified that miR-4295 promotes ATC cell proliferation by negatively regulates its target gene CDKN1A. In ATC cell lines, CCK-8 proliferation assay indicated that the cell proliferation was promoted by miR-4295, while miR-4295 inhibitor significantly inhibited the cell proliferation. Transwell assay showed that miR-4295 mimics significantly promoted the migration and invasion of ATC cells, whereas miR-4295 inhibitors significantly reduced cell migration and invasion. luciferase assays confirmed that miR-4295 directly bound to the 3'untranslated region of CDKN1A, and western blotting showed that miR-4295 suppressed the expression of CDKN1A at the protein levels. This study indicated that miR-4295 negatively regulates CDKN1A and promotes proliferation and invasion of ATC cell lines. Thus, miR-4295 may represent a potential therapeutic target for ATC intervention. - Highlights: • miR-4295 mimics promote the proliferation and invasion of ATC cells. • miR-4295 inhibitors inhibit the proliferation and invasion of ATC cells. • miR-4295 targets 3′UTR of CDKN1A in ATC cells. • miR-4295 negatively regulates CDKN1A in ATC cells.

  8. Microfluidic Molecular Assay Platform for the Detection of miRNAs...

    Office of Scientific and Technical Information (OSTI)

    Article: Microfluidic Molecular Assay Platform for the Detection of miRNAs, mRNAs, Proteins, and Post-translational Modifications at Single-cell Resolution. Citation Details...

  9. T-1025 IU SciBath-768 detector tests in MI-12

    SciTech Connect (OSTI)

    Tayloe, Rex; Cooper, R.; Garrison, L.; Thornton, T.; Rebenitsch, L.; DeJongh, Fritz; Loer, Benjamin; Ramberg, Erik; Yoo, Jonghee; /Fermilab

    2012-02-11

    This is a memorandum of understanding between the Fermi National Accelerator Laboratory (Fermilab) and the experimenters of Department of Physics and Center for Exploration of Energy and Matter, Indiana University, who have committed to participate in detector tests to be carried out during the 2012 Fermilab Neutrino program. The memorandum is intended solely for the purpose of recording expectations for budget estimates and work allocations for Fermilab, the funding agencies and the participating institutions. it reflects an arrangement that currently is satisfactory to the parties; however, it is recognized and anticipated that changing circumstances of the evolving research program will necessitate revisions. The parties agree to modify this memorandum to reflect such required adjustments. Actual contractual obligations will be set forth in separate documents. The experimenters propsoe to test their prototype 'SciBat-768' detector in the MI-12 building for 3 months (February-April) in Spring 2012. The major goal of this effort is to measure or limit the flux of beam-induced neutrons in a far-off-axis (> 45{sup o}) location of the Booster Neutrino Beamline (BNB). This flux is of interest for a proposed coherent neutral-current neutrino-argon elastic scattering experiment. A second goal is to collect more test data for the SciBath-768 to enable better understanding and calibration of the device. The SciBath-768 detector successfully ran for 3 months in the MINOS Underground Area in Fall 2011 as testbeam experiment T-1014 and is currently running above ground in the MINOS service building. For the run proposed here, the experiments are requesting: space in MI-12 in which to run the SciBath detector during February-April 2012 while the BNB is operating; technical support to help with moving the equipment on site; access to power, internet, and accelerator signals; and a small office space from which to run and monitor the experiment.

  10. Groundwater protection for the NuMI project

    SciTech Connect (OSTI)

    Wehmann, A.; Smart, W.; Menary, S.; Hylen, J.; Childress, S.

    1997-10-01

    The physics requirements for the long base line neutrino oscillation experiment MINOS dictate that the NuMI beamline be located in the aquifer at Fermilab. A methodology is described for calculating the level of radioactivation of groundwater caused by operation of this beamline. A conceptual shielding design for the 750 meter long decay pipe is investigated which would reduce radioactivation of the groundwater to below government standards. More economical shielding designs to meet these requirements are being explored. Also, information on local geology, hydrogeology, government standards, and a glossary have been included.

  11. The Nuclear Accident at Three Mile Island a Practical Lesson in the Fundamental Importance of Effective Communications

    SciTech Connect (OSTI)

    DeVine Jr, J.C.

    2008-07-01

    The Three Mile Island Unit 2 (TMI-2) accident in March 1979 had a profound effect on the course of commercial nuclear generation in the United States and around the world. And while the central elements of the accident were matters of nuclear engineering, design and operations, its consequences were compounded, and in some respects superseded, by extraordinarily ineffective communications by all parties at all levels. Communications failures during the accident and its aftermath caused misunderstanding, distrust, and incorrect emergency response - and seeded or reinforced public opposition to nuclear power that persists to this day. There are communications lessons from TMI that have not yet been fully learned, and some that once were learned but are now gradually being forgotten. The more glaring TMI communications problems were in the arena of external interactions and communications among the plant owner, the Nuclear Regulatory Commission (NRC), the media, and the public. Confusing, fragmented, and contradictory public statements early in the accident, regardless of cause, undermined all possibility for reasonable discourse thereafter. And because the TMI accident was playing out on a world stage, the breakdown in public trust had long term and widespread implications. At the plant site, both TMI-2 cleanup and restart of the undamaged TMI-1 unit met with years of public and political criticism, and attendant regulatory pressure. Across the nation, public trust in nuclear power and those who operate it plummeted, unquestionably contributing to the 25+ year hiatus in new plant orders. There were other, less visible but equally important, consequences of ineffective communications at TMI. The unplanned 'precautionary' evacuation urged by the governor two days after the accident - a life changing, traumatic event for thousands of residents - was prompted primarily by misunderstandings and miscommunications regarding the condition of the plant. And today, nearly 30

  12. Corrective Action Investigation Plan for Corrective Action Unit 552: Area 12 Muckpile and Ponds, Nevada Test Site, Nevada, Rev. No.: 1 with ROTC 1 and 2

    SciTech Connect (OSTI)

    David A. Strand

    2005-01-01

    This Corrective Action Investigation Plan (CAIP) contains project-specific information including facility descriptions, environmental sample collection objectives, and criteria for conducting site investigation activities at Corrective Action Unit (CAU) 552: Area 12 Muckpile and Ponds, Nevada Test Site (NTS), Nevada. This CAIP has been developed in accordance with the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996) that was agreed to by the State of Nevada, the U.S. Department of Energy (DOE), and the U.S. Department of Defense. The NTS is approximately 65 miles (mi) northwest of Las Vegas, Nevada (Figure 1-1). Corrective Action Unit 552 is comprised of the one Corrective Action Site which is 12-23-05, Ponds. One additional CAS, 12-06-04, Muckpile (G-Tunnel Muckpile), was removed from this CAU when it was determined that the muckpile is an active site. A modification to the FFACO to remove CAS 12-06-04 was approved by the Nevada Division of Environmental Protection (NDEP) on December 16, 2004. The G-Tunnel ponds were first identified in the 1991 Reynolds Electrical & Engineering Co., Inc. document entitled, ''Nevada Test Site Inventory of Inactive and Abandoned Facilities and Waste Sites'' (REECo, 1991). Corrective Action Unit 552 is being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Therefore, additional information will be obtained by conducting a corrective action investigation (CAI) prior to evaluating and selecting the corrective action alternatives for the site. The CAI will include field inspections, radiological surveys, and sampling of appropriate media. Data will also be obtained to support investigation-derived waste (IDW) disposal and potential future waste management decisions.

  13. Lower head creep rupture failure analysis associated with alternative accident sequences of the Three Mile Island Unit 2

    SciTech Connect (OSTI)

    Sang Lung, Chan

    2004-07-01

    The objective of this lower head creep rupture analysis is to assess the current version of MELCOR 1.8.5-RG against SCDAP/RELAP5 MOD 3.3kz. The purpose of this assessment is to investigate the current MELCOR in-vessel core damage progression phenomena including the model for the formation of a molten pool. The model for stratified molten pool natural heat transfer will be included in the next MELCOR release. Presently, MELCOR excludes the gap heat-transfer model for the cooling associated with the narrow gap between the debris and the lower head vessel wall. All these phenomenological models are already treated in SCDAP/RELAP5 using the COUPLE code to model the heat transfer of the relocated debris with the lower head based on a two-dimensional finite-element-method. The assessment should determine if current MELCOR capabilities adequately cover core degradation phenomena appropriate for the consolidated MELCOR code. Inclusion of these features should bring MELCOR much closer to a state of parity with SCDAP/RELAP5 and is a currently underway element in the MELCOR code consolidation effort. This assessment deals with the following analysis of the Three Mile Island Unit 2 (TMI-2) alternative accident sequences. The TMI-2 alternative accident sequence-1 includes the continuation of the base case of the TMI-2 accident with the Reactor Coolant Pumps (RCP) tripped, and the High Pressure Injection System (HPIS) throttled after approximately 6000 s accident time, while in the TMI-2 alternative accident sequence-2, the reactor coolant pumps is tripped after 6000 s and the HPIS is activated after 12,012 s. The lower head temperature distributions calculated with SCDAP/RELAP5 are visualized and animated with open source visualization freeware 'OpenDX'. (author)

  14. Review of the state of criticality of the Three Mile Island Unit 2 core and reactor vessel

    SciTech Connect (OSTI)

    Stratton, W.R. )

    1987-04-15

    The events during the early hours of the Three Mile Island Unit 2 (TMI-2) accident on March 28, 1979 caused the fuel in the reactor core to crumble or disintegrate, and then subside into a rubble structure more compact that its normal configuration. The present height of the core is about seven feet, five feet less than its normal configuration of 12 feet. With the same boron content and some or all of the control rod and burnable poison rod material as the normal core configuration, the collapsed structure is calculated to be more reactive. However, the reactor is assuredly subcritical at present because of the extraordinarily high boron concentration maintained in the coolant water. Four additional and different physical models are discussed briefly in the report to illustrate the margin of subcriticality, to provide a better estimate of the neutron multiplication factor, and to provide some understanding of the criticality effects of the important parameters. Two different finite, cylindrical models of a collapsed core are also presented in this report. The conclusion of this review is that the reactor is now very far subcritical with a boron concentration of 4350 ppM or more, and no conceivable rearrangement of fuel can create a critical state. Careful administrative control to maintain the boron concentration of the reactor coolant close to 5000 ppM, and controls to rigorously exclude addition of unborated water to the primary system, provide additional assurance that subcriticality will be maintained. The immediate corollary is that the defueling of the reactor vessel can proceed as planned, with complete confidence that such operations will remain subcritical. 20 refs.

  15. Revisiting Insights from Three Mile Island Unit 2 Postaccident Examinations and Evaluations in View of the Fukushima Daiichi Accident

    SciTech Connect (OSTI)

    Joy Rempe; Mitchell Farmer; Michael Corradini; Larry Ott; Randall Gauntt; Dana Powers

    2012-11-01

    The Three Mile Island Unit 2 (TMI-2) accident, which occurred on March 28, 1979, led industry and regulators to enhance strategies to protect against severe accidents in commercial nuclear power plants. Investigations in the years after the accident concluded that at least 45% of the core had melted and that nearly 19 tonnes of the core material had relocated to the lower head. Postaccident examinations indicate that about half of that material formed a solid layer near the lower head and above it was a layer of fragmented rubble. As discussed in this paper, numerous insights related to pressurized water reactor accident progression were gained from postaccident evaluations of debris, reactor pressure vessel (RPV) specimens, and nozzles taken from the RPV. In addition, information gleaned from TMI-2 specimen evaluations and available data from plant instrumentation were used to improve severe accident simulation models that form the technical basis for reactor safety evaluations. Finally, the TMI-2 accident led the nuclear community to dedicate considerable effort toward understanding severe accident phenomenology as well as the potential for containment failure. Because available data suggest that significant amounts of fuel heated to temperatures near melting, the events at Fukushima Daiichi Units 1, 2, and 3 offer an unexpected opportunity to gain similar understanding about boiling water reactor accident progression. To increase the international benefit from such an endeavor, we recommend that an international effort be initiated to (a) prioritize data needs; (b) identify techniques, samples, and sample evaluations needed to address each information need; and (c) help finance acquisition of the required data and conduct of the analyses.

  16. miR-129 suppresses tumor cell growth and invasion by targeting PAK5 in hepatocellular carcinoma

    SciTech Connect (OSTI)

    Zhai, Jian; Qu, Shuping; Li, Xiaowei; Zhong, Jiaming; Chen, Xiaoxia; Qu, Zengqiang; Wu, Dong

    2015-08-14

    Emerging evidence suggests that microRNAs (miRNAs) play important roles in regulating HCC development and progression; however, the mechanisms by which their specific functions and mechanisms remained to be further explored. miR-129 has been reported in gastric cancers, lung cancer and colon cancer. In this study, we disclosed a new tumor suppresser function of miR-129 in HCC. We also found the downregulation of miR-129 occurred in nearly 3/4 of the tumors examined (56/76) compared with adjacent nontumorous tissues, which was more importantly, correlated to the advanced stage and vascular invasion. We then demonstrated that miR-129 overexpression attenuated HCC cells proliferation and invasion, inducing apoptosis in vitro. Moreover, we used miR-129 antagonist and found that anti-miR-129 promoted HCC cells malignant phenotypes. Mechanistically, our further investigations revealed that miR-129 suppressed cell proliferation and invasion by targeting the 3’-untranslated region of PAK5, as well as miR-129 silencing up-regulated PAK5 expression. Moreover, miR-129 expression was inversely correlated with PAK5 expression in 76 cases of HCC samples. RNA interference of PAK5 attenuated anti-miR-129 mediated cell proliferation and invasion in HCC cells. Taken together, these results demonstrated that miR-129 suppressed tumorigenesis and progression by directly targeting PAK5, defining miR-129 as a potential treatment target for HCC. - Highlights: • Decreased of miR-129 is found in HCC and associated with advanced stage and metastasis. • miR-129 suppresses proliferation and invasion of HCC cells. • miR-129 directly targets the 3′ UTR of PAK5 and diminishes PAK5 expression. • PAK5 is involved in miR-129 mediated suppression functions.

  17. MiR-153 inhibits migration and invasion of human non-small-cell lung cancer by targeting ADAM19

    SciTech Connect (OSTI)

    Shan, Nianxi; Shen, Liangfang; Wang, Jun; He, Dan; Duan, Chaojun

    2015-01-02

    Highlights: • Decreased miR-153 and up-regulated ADAM19 are correlated with NSCLC pathology. • MiR-153 inhibits the proliferation and migration and invasion of NSCLC cells in vitro. • ADAM19 is a direct target of miR-153. • ADAM19 is involved in miR-153-suppressed migration and invasion of NSCLC cells. - Abstract: MiR-153 was reported to be dysregulated in some human cancers. However, the function and mechanism of miR-153 in lung cancer cells remains unknown. In this study, we investigated the role of miR-153 in human non-small-cell lung cancer (NSCLC). Using qRT-PCR, we demonstrated that miR-153 was significantly decreased in clinical NSCLC tissues and cell lines, and downregulation of miR-153 was significantly correlated with lymph node status. We further found that ectopic expression of miR-153 significantly inhibited the proliferation and migration and invasion of NSCLC cells in vitro, suggesting that miR-153 may be a novel tumor suppressor in NSCLC. Further integrated analysis revealed that ADAM19 is as a direct and functional target of miR-153. Luciferase reporter assay demonstrated that miR-153 directly targeted 3′UTR of ADAM19, and correlation analysis revealed an inverse correlation between miR-153 and ADAM19 mRNA levels in clinical NSCLC tissues. Knockdown of ADAM19 inhibited migration and invasion of NSCLC cells which was similar with effects of overexpression of miR-153, while overexpression of ADAM19 attenuated the function of miR-153 in NSCLC cells. Taken together, our results highlight the significance of miR-153 and ADAM19 in the development and progression of NSCLC.

  18. Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells

    SciTech Connect (OSTI)

    Li, Junxia; Shan, Fabo; Xiong, Gang; Wang, Ju-Ming; Wang, Wen-Lin; Xu, Xueqing; Bai, Yun

    2014-03-28

    Highlights: • MiR-146b promotes esophageal cancer cell proliferation. • MiR-146b inhibits esophageal cancer cell apoptosis. • C/EBPβ directly binds to miR-146b promoter conserved region. • MiR-146b is up-regulated by C/EBPβ LAP2 transcriptional activation. - Abstract: Recent clinical study indicated that up-regulation of miR-146b was associated with poor overall survival of patients in esophageal squamous cell carcinoma. However, the underlying mechanism of miR-146b dysregulation remains to be explored. Here we report that miR-146b promotes cell proliferation and inhibits cell apoptosis in esophageal cancer cell lines. Mechanismly, two C/EBPβ binding motifs are located in the miR-146b promoter conserved region. Among the three isoforms of C/EBPβ, C/EBPβ LAP2 positively regulated miR-146b expression and increases miR-146b levels in a dose-dependent manner through transcription activation of miR-146b gene. Together, these results suggest a miR-146b regulatory mechanism involving C/EBPβ, which may contribute to the up-regulation of miR-146b in esophageal squamous cell carcinoma.

  19. miR-30a suppresses breast cancer cell proliferation and migration by targeting Eya2

    SciTech Connect (OSTI)

    Fu, Jing; Xu, Xiaojie; Kang, Lei; Zhou, Liying; Wang, Shibin; Lu, Juming; Cheng, Long; Fan, Zhongyi; Yuan, Bin; Tian, Peirong; Zheng, Xiaofei; Yu, Chengze; Ye, Qinong; Lv, Zhaohui

    2014-03-07

    Highlights: • miR-30a represses Eya2 expression by binding to the 3′-untranslated region of Eya2. • The miR-30a/EYA2 axis regulates breast cancer cell proliferation and migration. • The miR-30a/EYA2 axis modulates G1/S cell cycle progression. • The miR-30a/EYA2 axis is dysregulated in breast cancer patients. - Abstract: Eye absent (Eya) proteins are involved in cell fate determination in a broad spectrum of cells and tissues. Aberrant expression of Eya2 has been documented in a variety of cancers and correlates with clinical outcome. However, whether microRNAs (miRNAs) can regulate Eya2 expression remains unknown. Here, we show that miR-30a represses Eya2 expression by binding to the 3′-untranslated region of Eya2. Overexpression of Eya2 in miR-30a-transfected breast cancer cells effectively rescued the inhibition of cell proliferation and migration caused by miR-30a. Knockdown of Eya2 by small-interfering RNA (siRNA) in breast cancer cells mimicked the effect induced by miR-30a and abolished the ability of miR-30a to regulate breast cancer cell proliferation and migration. The miR-30a/Eya2 axis could regulate G1/S cell cycle progression, accompanied by the modulation of expression of cell cycle-related proteins, including cyclin A, cyclin D1, cyclin E, and c-Myc. Moreover, miR-30a expression was downregulated in breast cancer patients, and negatively correlated with Eya2, which was upregulated in breast cancer patients. These data suggest that the miR-30a/Eya2 axis may play an important role in breast cancer development and progression and that miR-30a activation or Eya2 inhibition may be a useful strategy for cancer treatment.

  20. Kirkland gets license in hot Philippines area

    SciTech Connect (OSTI)

    Kirkland, A.S.

    1992-08-03

    This paper reports that Kirkland As, Oslo, has received a geophysical survey and exploration contract (GSEC) in a sizzling exploration and development theater off the Philippines. The license covers about 6,000 sq miles of undisputed waters, with depths mostly less than 300 ft, and lies in the Reed Bank area off Northwest Palawan Island, where several major oil and gas strikes have been made recently. Kirkland has 1 year in which to carry out its seismic work commitment. The terms of the GSEC then give an option to drill one well in a 6 month period. Once the results have been analyzed, the company can either drill another well or enter into a service contract for the license. Kirkland has a 65% share in the license, with the remainder split between Philippine companies Philodrill Corp., Beguet Mining Corp. subsidiary Petrofields, and Seafront Resources Corp. The Philippines is one of Kirkland's main areas of activity, the Kirkland Commercial Manager Ralph Baxter.

  1. miR-92a is upregulated in cervical cancer and promotes cell proliferation and invasion by targeting FBXW7

    SciTech Connect (OSTI)

    Zhou, Chuanyi; Shen, Liangfang; Mao, Lei; Wang, Bing; Li, Yang; Yu, Huizhi

    2015-02-27

    MicroRNAs (miRNAs) are involved in the cervical carcinogenesis and progression. In this study, we investigated the role of miR-92a in progression and invasion of cervical cancer. MiR-92a was significantly upregulated in cervical cancer tissues and cell lines. Overexpression of miR-92a led to remarkably enhanced proliferation by promoting cell cycle transition from G1 to S phase and significantly enhanced invasion of cervical cancer cells, while its knockdown significantly reversed these cellular events. Bioinformatics analysis suggested F-box and WD repeat domain-containing 7 (FBXW7) as a novel target of miR-92a, and miR-92a suppressed the expression level of FBXW7 mRNA by direct binding to its 3′-untranslated region (3′UTR). Expression of miR-92a was negatively correlated with FBXW7 in cervical cancer tissues. Furthermore, Silencing of FBXW7 counteracted the effects of miR-92a suppression, while its overexpression reversed oncogenic effects of miR-92a. Together, these findings indicate that miR-92a acts as an onco-miRNA and may contribute to the progression and invasion of cervical cancer, suggesting miR-92a as a potential novel diagnostic and therapeutic target of cervical cancer. - Highlights: • miR-92a is elevated in cervical cancer tissues and cell lines. • miR-92a promotes cervical cancer cell proliferation, cell cycle transition from G1 to S phase and invasion. • FBXW7 is a direct target of miR-92a. • FBXW7 counteracts the oncogenic effects of miR-92a on cervical cancer cells.

  2. miR-182 targets CHL1 and controls tumor growth and invasion in papillary thyroid carcinoma

    SciTech Connect (OSTI)

    Zhu, Hongling; Fang, Jin; Zhang, Jichen; Zhao, Zefei; Liu, Lianyong; Wang, Jingnan; Xi, Qian; Gu, Mingjun

    2014-07-18

    Highlights: miR-182 and CHL1 expression patterns are negatively correlated. CHL1 is a direct target of miR-182 in PTC cells. miR-182 suppression inhibits PTC cell growth and invasion. CHL1 is involved in miR-182-mediated cell behavior. - Abstract: In this study, we investigated the role and underlying mechanism of action of miR-182 in papillary thyroid carcinoma (PTC). Bioinformatics analysis revealed close homolog of LI (CHL1) as a potential target of miR-182. Upregulation of miR-182 was significantly correlated with CHL1 downregulation in human PTC tissues and cell lines. miR-182 suppressed the expression of CHL1 mRNA through direct targeting of the 3?-untranslated region (3?-UTR). Downregulation of miR-182 suppressed growth and invasion of PTC cells. Silencing of CHL1 counteracted the effects of miR-182 suppression, while its overexpression mimicked these effects. Our data collectively indicate that miR-182 in PTC promotes cell proliferation and invasion through direct suppression of CHL1, supporting the potential utility of miR-182 inhibition as a novel therapeutic strategy against PTC.

  3. Non-canonical microRNAs miR-320 and miR-702 promote proliferation in Dgcr8-deficient embryonic stem cells

    SciTech Connect (OSTI)

    Kim, Byeong-Moo; Choi, Michael Y.

    2012-09-21

    Highlights: Black-Right-Pointing-Pointer Embryonic stem cells (ESCs) lacking non-canonical miRNAs proliferate slower. Black-Right-Pointing-Pointer miR-320 and miR-702 are two non-canonical miRNAs expressed in ESCs. Black-Right-Pointing-Pointer miR-320 and miR-702 promote proliferation of Dgcr8-deficient ESCs. Black-Right-Pointing-Pointer miR-320 targets p57 and helps to release Dgcr8-deficient ESCs from G1 arrest. Black-Right-Pointing-Pointer miR-702 targets p21 and helps to release Dgcr8-deficient ESCs from G1 arrest. -- Abstract: MicroRNAs are known to contribute significantly to stem cell phenotype by post-transcriptionally regulating gene expression. Most of our knowledge of microRNAs comes from the study of canonical microRNAs that require two sequential cleavages by the Drosha/Dgcr8 heterodimer and Dicer to generate mature products. In contrast, non-canonical microRNAs bypass the cleavage by the Drosha/Dgcr8 heterodimer within the nucleus but still require cytoplasmic cleavage by Dicer. The function of non-canonical microRNAs in embryonic stem cells (ESCs) remains obscure. It has been hypothesized that non-canonical microRNAs have important roles in ESCs based upon the phenotypes of ESC lines that lack these specific classes of microRNAs; Dicer-deficient ESCs lacking both canonical and non-canonical microRNAs have much more severe proliferation defect than Dgcr8-deficient ESCs lacking only canonical microRNAs. Using these cell lines, we identified two non-canonical microRNAs, miR-320 and miR-702, that promote proliferation of Dgcr8-deficient ESCs by releasing them from G1 arrest. This is accomplished by targeting the 3 Prime -untranslated regions of the cell cycle inhibitors p57 and p21 and thereby inhibiting their expression. This is the first report of the crucial role of non-canonical microRNAs in ESCs.

  4. NuMI proton kicker extraction magnet termination resistor system

    SciTech Connect (OSTI)

    Reeves, S.R.; Jensen, C.C.; /Fermilab

    2005-05-01

    The temperature stability of the kicker magnet termination resistor assembly directly affects the field flatness and amplitude stability. Comprehensive thermal enhancements were made to the existing Main Injector resistor assembly design to satisfy NuMI performance specifications. Additionally, a fluid-processing system utilizing Fluorinert{reg_sign} FC-77 high-voltage dielectric was built to precisely control the setpoint temperature of the resistor assembly from 70 to 120F, required to maintain constant resistance during changing operational modes. The Fluorinert{reg_sign} must be continually processed to remove hazardous breakdown products caused by radiation exposure to prevent chemical attack of system components. Design details of the termination resistor assembly and Fluorinert{reg_sign} processing system are described. Early performance results will be presented.

  5. Downregulation of miRNA-30c and miR-203a is associated with hepatitis C virus core protein-induced epithelial–mesenchymal transition in normal hepatocytes and hepatocellular carcinoma cells

    SciTech Connect (OSTI)

    Liu, Dongjing; Wu, Jilin; Liu, Meizhou; Yin, Hui; He, Jiantai; Zhang, Bo

    2015-09-04

    Hepatitis C virus (HCV) Core protein has been demonstrated to induce epithelial–mesenchymal transition (EMT) and is associated with cancer progression of hepatocellular carcinoma (HCC). However, how the Core protein regulates EMT is still unclear. In this study, HCV Core protein was overexpressed by an adenovirus. The protein levels of EMT markers were measured by Western blot. The xenograft animal model was established by inoculation of HepG2 cells. Results showed that ectopic expression of HCV core protein induced EMT in L02 hepatocytes and HepG2 tumor cells by upregulating vimentin, Sanl1, and Snal2 expression and downregulating E-cadherin expression. Moreover, Core protein downregulated miR-30c and miR-203a levels in L02 and HepG2 cells, but artificial expression of miR-30c and miR-203a reversed Core protein-induced EMT. Further analysis showed that ectopic expression of HCV core protein stimulated cell proliferation, inhibited apoptosis, and increased cell migration, whereas artificial expression of miR-30c and miR-203a significantly reversed the role of Core protein in these cell functions in L02 and HepG2 cells. In the HepG2 xenograft tumor models, artificial expression of miR-30c and miR-203a inhibited EMT and tumor growth. Moreover, L02 cells overexpressing Core protein can form tumors in nude mice. In HCC patients, HCV infection significantly shortened patients' survival time, and loss of miR-30c and miR-203 expression correlated with poor survival. In conclusion, HCV core protein downregulates miR-30c and miR-203a expression, which results in activation of EMT in normal hepatocytes and HCC tumor cells. The Core protein-activated-EMT is involved in the carcinogenesis and progression of HCC. Loss of miR-30c and miR-203a expression is a marker for the poor prognosis of HCC. - Highlights: • HCV core protein downregulates miR-30c and miR-203a expression. • Downregulation of miR-30c and miR-203a activates EMT. • Activated-EMT is involved in the

  6. miR-128 and its target genes in tumorigenesis and metastasis

    SciTech Connect (OSTI)

    Li, Molin, E-mail: molin_li@hotmail.com [Dalian Medical University, Dalian 116044 (China); Fu, Weiming [Center for Food Safety and Environmental Technology, Guangzhou Institute of Advanced Technology, Chinese Academy of Sciences, Guangzhou 511458 (China); Wo, Lulu; Shu, Xiaohong [Dalian Medical University, Dalian 116044 (China); Liu, Fang [The second affiliated hospital of Dalian Medical University, Dalian 116023 (China); Li, Chuangang, E-mail: li_chuangang@sina.com [The second affiliated hospital of Dalian Medical University, Dalian 116023 (China)

    2013-12-10

    MicroRNAs (miRNAs) are a class of endogenous, non-coding, 1824 nucleotide length single-strand RNAs that could modulate gene expression at post-transcriptional level. Previous studies have shown that miR-128 enriched in the brain plays an important role in the development of nervous system and the maintenance of normal physical functions. Aberrant expression of miR-128 has been detected in many types of human tumors and its validated target genes are involved in cancer-related biological processes such as cell proliferation, differentiation and apoptosis. In this review, we will summarize the roles of miR-128 and its target genes in tumorigenesis and metastasis. - Highlights: Aberrant expression of miR-128 can be observed in many kinds of malignant tumors. The molecular mechanisms regulating miR-128 expression are elucidated. Roles of miR-128 and its target genes in tumorigenesis and metastasis are summarized.

  7. miR-125b inhibits osteoblastic differentiation by down-regulation of cell proliferation

    SciTech Connect (OSTI)

    Mizuno, Yosuke; Yagi, Ken; Tokuzawa, Yoshimi; Kanesaki-Yatsuka, Yukiko; Suda, Tatsuo; Katagiri, Takenobu; Fukuda, Toru; Maruyama, Masayoshi; Okuda, Akihiko; Amemiya, Tomoyuki; Kondoh, Yasumitsu; Tashiro, Hideo; Okazaki, Yasushi

    2008-04-04

    Although various microRNAs regulate cell differentiation and proliferation, no miRNA has been reported so far to play an important role in the regulation of osteoblast differentiation. Here we describe the role of miR-125b in osteoblastic differentiation in mouse mesenchymal stem cells, ST2, by regulating cell proliferation. The expression of miR-125b was time-dependently increased in ST2 cells, and the increase in miR-125b expression was attenuated in osteoblastic-differentiated ST2 cells induced by BMP-4. The transfection of exogenous miR-125b inhibited proliferation of ST2 cells and caused inhibition of osteoblastic differentiation. In contrast, when the endogenous miR-125b was blocked by transfection of its antisense RNA molecule, alkaline phosphatase activity after BMP-4 treatment was elevated. These results strongly suggest that miR-125b is involved in osteoblastic differentiation through the regulation of cell proliferation.

  8. Overexpression of miR-206 suppresses glycolysis, proliferation and migration in breast cancer cells via PFKFB3 targeting

    SciTech Connect (OSTI)

    Ge, Xin; Lyu, Pengwei; Cao, Zhang; Li, Jingruo; Guo, Guangcheng; Xia, Wanjun; Gu, Yuanting

    2015-08-07

    miRNAs, sorting as non-coding RNAs, are differentially expressed in breast tumor and act as tumor promoters or suppressors. miR-206 could suppress the progression of breast cancer, the mechanism of which remains unclear. The study here was aimed to investigate the effect of miR-206 on human breast cancers. We found that miR-206 was down-regulated while one of its predicted targets, 6-Phosphofructo-2-kinase (PFKFB3) was up-regulated in human breast carcinomas. 17β-estradiol dose-dependently decreased miR-206 expression as well as enhanced PFKFB3 mRNA and protein expression in estrogen receptor α (ERα) positive breast cancer cells. Furthermore, we identified that miR-206 directly interacted with 3′-untranslated region (UTR) of PFKFB3 mRNA. miR-206 modulated PFKFB3 expression in MCF-7, T47D and SUM159 cells, which was influenced by 17β-estradiol depending on ERα expression. In addition, miR-206 overexpression impeded fructose-2,6-bisphosphate (F2,6BP) production, diminished lactate generation and reduced cell proliferation and migration in breast cancer cells. In conclusion, our study demonstrated that miR-206 regulated PFKFB3 expression in breast cancer cells, thereby stunting glycolysis, cell proliferation and migration. - Highlights: • miR-206 was down-regulated and PFKFB3 was up-regulated in human breast carcinomas. • 17β-estradiol regulated miR-206 and PFKFB3 expression in ERα+ cancer cells. • miR-206directly interacted with 3′-UTR of PFKFB3 mRNA. • miR-206 fructose-2,6-bisphosphate (F2,6BP) impeded production and lactate generation. • miR-206 reduced cell proliferation and migration in breast cancer cells.

  9. AMENDMENT OF SOLICITATION/MODIFICATlON OF CONTRACT MI54 I See...

    National Nuclear Security Administration (NNSA)

    MI54 I See Block 16C I REQ. NO. Babcock & Wilcox Technical Services Pantex, LLC PO Box 30020 Amarillo, TX 79120 2. AMENDMENTIMODIFICATION NO. 1 3. EFFECTIVE DATE 1 4. ...

  10. File:USDA-CE-Production-GIFmaps-MI.pdf | Open Energy Information

    Open Energy Info (EERE)

    MI.pdf Jump to: navigation, search File File history File usage Michigan Ethanol Plant Locations Size of this preview: 463 599 pixels. Other resolution: 464 600 pixels. Full...

  11. Forrest Conservation Area : Management & Implementation FY 2004 Annual Report.

    SciTech Connect (OSTI)

    Smith, Brent

    2008-12-01

    The Confederated Tribes of Warm Springs Reservation of Oregon (Tribes) acquired the Forrest Conservation Area during July of 2002. The property is located in the Upper John Day subbasin within the Columbia basin. The property consists of two parcels comprising 4,232 acres. The Mainstem parcel consists of 3,445 acres and is located 1/2 mile to the east of Prairie City, Oregon on the mainstem John Day River. The Middle Fork parcel consists of 786 acres and is located one mile to the west of the town of Austin, OR on the Middle Fork John Day River. The Forrest Conservation Area is under a memorandum of agreement with the Bonneville Power Administration (BPA) to provide an annual written report generally describing the real property interests of the project and management activities undertaken or in progress. Acquisition of the Forrest Conservation Area was funded by BPA as part of their program to protect, mitigate, and enhance fish and wildlife habitat affected by hydroelectric facilities on the Columbia River and its tributaries. The intent of the Conservation Area is to partially mitigate fish and wildlife impacts for the John Day Dam on the Columbia River as outlined in the Northwest Power Planning Council's Wildlife Program (NPPC 1994, {section}11.1, {section}7.6). While the Tribes hold fee-title to the property, the BPA has assured a level of management funding for the protection and restoration of fish and wildlife habitat through a memorandum of agreement.

  12. Climate Action Champions: Sault Ste. Marie Tribe of Chippewa Indians, MI |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Sault Ste. Marie Tribe of Chippewa Indians, MI Climate Action Champions: Sault Ste. Marie Tribe of Chippewa Indians, MI The Sault Ste. Marie Tribe of Chippewa Indians is a 44,000-strong federally recognized Indian tribe that is an economic, social and cultural force in its community across the eastern Upper Peninsula counties of Chippewa, Luce, Mackinac, Schoolcraft, Alger, Delta and Marquette, with housing and tribal centers, casinos, and other enterprises that employ

  13. Corrective action investigation plan for CAU Number 453: Area 9 Landfill, Tonopah Test Range

    SciTech Connect (OSTI)

    1997-05-14

    This Corrective Action Investigation Plan (CAIP) contains the environmental sample collection objectives and criteria for conducting site investigation activities at the Area 9 Landfill, Corrective Action Unit (CAU) 453/Corrective Action (CAS) 09-55-001-0952, which is located at the Tonopah Test Range (TTR). The TTR, included in the Nellis Air Force Range, is approximately 255 kilometers (140 miles) northwest of Las Vegas, Nevada. The Area 9 Landfill is located northwest of Area 9 on the TTR. The landfill cells associated with CAU 453 were excavated to receive waste generated from the daily operations conducted at Area 9 and from range cleanup which occurred after test activities.

  14. Italy to open exclusive Po basin area in 1992

    SciTech Connect (OSTI)

    Rigo, F.

    1991-05-27

    Under new regulations of the European Community, no oil and gas state monopoly is allowed in the member countries. As a consequence, by 1992 Italy will open for application by international oil companies all lands not covered by exploitation concessions in the ENI exclusive area. This monopoly area covers the prolific Po basin, the cradle of the Italian state oil company AGIP SpA, Milan. Due to profits derived from numerous gas discoveries of the 1950s in this basin, AGIP, a relatively small enterprise at that time, could eventually afford to expand in Italy and abroad and through successful exploration achieve status of a major international oil company. The ENI exclusive area covers the Po and Veneto plains and adjacent 15 km of territorial waters, for a total surface of more than 23,000 sq miles. The area to become available for exploration will be regulated by the Italian petroleum law, for one of the most favorable in the world.

  15. Next Update: November 2016 Geographic Area Capacity In-Service

    U.S. Energy Information Administration (EIA) Indexed Site

    Geographic Area Capacity In-Service Data Year NERC Region Type Operating (kV) Design (kV) Rating (MVa) Month/Year From Terminal To Terminal Length (Miles) Type Company Code Company Name Organizational Type Ownership (Percent) Project Name Level of Certainty Primary Driver 1 Primary Driver 2 2014 FRCC AC 200-299 115 460 1/2016 SUB 4 230.00 SUB 7 230.00 3.8 OH 18445 of Tallahassee M 100% 0.00 - SUB 7 230.00 Under Constructio Reliability 2014 FRCC AC 100-120 115 232 12/2016 Sub 14 115 Sub 7 115 6.0

  16. miR-196a targets netrin 4 and regulates cell proliferation and migration of cervical cancer cells

    SciTech Connect (OSTI)

    Zhang, Jie; Zheng, Fangxia; Yu, Gang; Yin, Yanhua; Lu, Qingyang

    2013-11-01

    Highlights: miR-196a was overexpressed in cervical cancer tissue compared to normal tissue. miR-196a expression elevated proliferation and migration of cervical cancer cells. miR-196a inhibited NTN4 expression by binding 3?-UTR region of NTN4 mRNA. NTN4 inversely correlated with miR-196a expression in cervical tissue and cell line. NTN4 expression was low in cervical cancer tissue compared to normal tissue. -- Abstract: Recent research has uncovered tumor-suppressive and oncogenic potential of miR-196a in various tumors. However, the expression and mechanism of its function in cervical cancer remains unclear. In this study, we assess relative expression of miR-196a in cervical premalignant lesions, cervical cancer tissues, and four cancer cell lines using quantitative real-time PCR. CaSki and HeLa cells were treated with miR-196a inhibitors, mimics, or pCDNA/miR-196a to investigate the role of miR-196a in cancer cell proliferation and migration. We demonstrated that miR-196a was overexpressed in cervical intraepithelial neoplasia 23 and cervical cancer tissue. Moreover, its expression contributes to the proliferation and migration of cervical cancer cells, whereas inhibiting its expression led to a reduction in proliferation and migration. Five candidate targets of miR-196a chosen by computational prediction and Cervical Cancer Gene Database search were measured for their mRNA in both miR-196a-overexpressing and -depleted cancer cells. Only netrin 4 (NTN4) expression displayed an inverse association with miR-196a. Fluorescent reporter assays revealed that miR-196a inhibited NTN4 expression by targeting one binding site in the 3?-untranslated region (3?-UTR) of NTN4 mRNA. Furthermore, qPCR and Western blot assays verified NTN4 expression was downregulated in cervical cancer tissues compared to normal controls, and in vivo mRNA level of NTN4 inversely correlated with miR-196a expression. In summary, our findings provide new insights about the functional role of

  17. NREL Employees and Managing Partner Pledge $500,000 to Aid Area Charities -

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    News Releases | NREL Employees and Managing Partner Pledge $500,000 to Aid Area Charities 2013 charitable giving campaign surpasses previous giving record December 13, 2012 The employees of the National Renewable Energy Laboratory (NREL) and the Alliance for Sustainable Energy, LLC, have pledged more than $500,000 to support local charities during the lab's annual holiday giving campaign. NREL employees have committed more than $466,000 to the Partnership for Colorado, Mile High United Way

  18. miR-214 promotes the proliferation and invasion of osteosarcoma cells through direct suppression of LZTS1

    SciTech Connect (OSTI)

    Xu, Zhengyu; Wang, Tao

    2014-06-27

    Highlights: • miR-214 is upregulated in human OS tissues and inversely correlated with LZTS1 expression. • miR-214 directly targets LZTS1 by binding to its 3′-UTR. • miR-214 promotes OS cell proliferation, invasion and tumor growth. • Overexpression of LZTS1 reverses miR-214-induced proliferation and invasion of OS cells. - Abstract: Previous studies have shown that miR-214 functions either as an oncogene or a tumor suppressor in various human cancer types. The role of this microRNA in osteosarcoma (OS) is presently unclear. Here, we demonstrated that miR-214 is frequently upregulated in OS specimens, compared with noncancerous bone tissues. Bioinformatics analysis further revealed leucine zipper, putative tumor suppressor 1 (LZTS1) as a potential target of miR-214. Expression patterns of miR-214 were inversely correlated with those of LZTS1 mRNA and protein in OS tissues. Data from reporter assays showed that miR-214 directly binds to the 3′-untranslated region (3′-UTR) of LZTS1 mRNA and suppresses expression at both transcriptional and translational levels. In functional assays, miR-214 promoted OS cell proliferation, invasion and tumor growth in nude mice, which could be reversed by overexpression of LZTS1. Taken together, our data provide compelling evidence that miR-214 functions as an onco-miRNA in OS, and its oncogenic effects are mediated chiefly through downregulation of LZTS1.

  19. miR-421 induces cell proliferation and apoptosis resistance in human nasopharyngeal carcinoma via downregulation of FOXO4

    SciTech Connect (OSTI)

    Chen, Liang; Department of Otolaryngology, Guangzhou General Hospital of PLA Guangzhou Command, Guangzhou 510010 ; Tang, Yanping; Wang, Jian; Yan, Zhongjie; Xu, Ruxiang

    2013-06-14

    Highlights: •miR-421 is upregulated in nasopharyngeal carcinoma. •miR-421 induces cell proliferation and apoptosis resistance. •FOXO4 is a direct and functional target of miR-421. -- Abstract: microRNAs have been demonstrated to play important roles in cancer development and progression. Hence, identifying functional microRNAs and better understanding of the underlying molecular mechanisms would provide new clues for the development of targeted cancer therapies. Herein, we reported that a microRNA, miR-421 played an oncogenic role in nasopharyngeal carcinoma. Upregulation of miR-421 induced, whereas inhibition of miR-421 repressed cell proliferation and apoptosis resistance. Furthermore, we found that upregulation of miR-421 inhibited forkhead box protein O4 (FOXO4) signaling pathway following downregulation of p21, p27, Bim and FASL expression by directly targeting FOXO4 3′UTR. Additionally, we demonstrated that FOXO4 expression is critical for miR-421-induced cell growth and apoptosis resistance. Taken together, our findings not only suggest that miR-421 promotes nasopharyngeal carcinoma cell proliferation and anti-apoptosis, but also uncover a novel regulatory mechanism for inactivation of FOXO4 in nasopharyngeal carcinoma.

  20. Streamlined Approach for Environmental Restoration (SAFER) Plan for Corrective Action Unit 553: Areas 19, 20 Mud Pits and Cellars, Nevada Test Site, Nevada, Rev. No. 0

    SciTech Connect (OSTI)

    Boehlecke, Robert F.

    2006-11-01

    This Streamlined Approach for Environmental Restoration (SAFER) Plan addresses the actions necessary for the closure of Corrective Action Unit (CAU) 553: Areas 19, 20 Mud Pits and Cellars, Nevada Test Site (NTS), Nevada. It has been developed in accordance with the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996) that was agreed to by the State of Nevada, the U.S. Department of Energy (DOE), and the U.S. Department of Defense. A SAFER may be performed when the following criteria are met: (1) Conceptual corrective actions are clearly identified (although some degree of investigation may be necessary to select a specific corrective action before completion of the Corrective Action Investigation [CAI]); (2) Uncertainty of the nature, extent, and corrective action must be limited to an acceptable level of risk; (3) The SAFER Plan includes decision points and criteria for making data quality objective (DQO) decisions. The purpose of the investigation will be to document and verify the adequacy of existing information; to affirm the decision for clean closure, closure in place, or no further action; and to provide sufficient data to implement the corrective action. The actual corrective action selected will be based on characterization activities implemented under this SAFER Plan. This SAFER Plan identifies decision points developed in cooperation with the Nevada Department of Environmental Protection (NDEP), where the DOE, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) will reach consensus with the NDEP before beginning the next phase of work. Corrective Action Unit 553 is located in Areas 19 and 20 of the NTS, approximately 65 miles (mi) northwest of Las Vegas, Nevada (Figure 1-1). Corrective Action Unit 553 is comprised of the four Corrective Action Sites (CASs) shown on Figure 1-1 and listed below: 19-99-01, Mud Spill; 19-99-11, Mud Spill; 20-09-09, Mud Spill; and 20-99-03, Mud Spill. There is sufficient information and process

  1. Roles of miRNAs in microcystin-LR-induced Sertoli cell toxicity

    SciTech Connect (OSTI)

    Zhou, Yuan; Wang, Hui; Wang, Cong; Qiu, Xuefeng; Benson, Mikael; Yin, Xiaoqin; Xiang, Zou; Li, Dongmei; and others

    2015-08-15

    Microcystin (MC)-LR, a cyclic heptapeptide, is a potent reproductive system toxin. To understand the molecular mechanisms of MC-induced reproductive system cytotoxicity, we evaluated global changes of miRNA and mRNA expression in mouse Sertoli cells following MC-LR treatment. Our results revealed that the exposure to MC-LR resulted in an altered miRNA expression profile that might be responsible for the modulation of mRNA expression. Bio-functional analysis indicated that the altered genes were involved in specific cellular processes, including cell death and proliferation. Target gene analysis suggested that junction injury in Sertoli cells exposed to MC-LR might be mediated by miRNAs through the regulation of the Sertoli cell-Sertoli cell pathway. Collectively, these findings may enhance our understanding on the modes of action of MC-LR on mouse Sertoli cells as well as the molecular mechanisms underlying the toxicity of MC-LR on the male reproductive system. - Highlights: • miRNAs were altered in Sertoli cells exposed to MC-LR. • Alerted genes were involved in different cell functions including the cell morphology. • MC-LR adversely affected Sertoli cell junction formation through the regulating miRNAs.

  2. EIS-0323-S1: Sacramento Area Voltage Support Project Supplemental Environmental Impact Statement and Environmental Impact Report, Placer, Sacramento, and Sutter Counties, California

    Office of Energy Efficiency and Renewable Energy (EERE)

    Construction and operation has been proposed of approximately 31 to 38 miles of new, double-circuit, 230-kilovolt (kV) transmission line between Western's O'Banion Substation and the area just south of SMUD's Elverta Substation and the reconstruciton of SMUD's existing 230-kV/115kV transmission line between SMUD's Elverta and Natomas substations.

  3. Subsurface geology and potential for geopressured-geothermal energy in the Turtle Bayou field-Kent Bayou field area, Terrebonne Parish, Louisiana

    SciTech Connect (OSTI)

    Moore, D.R.

    1982-09-01

    A 216 square mile area approximately 65 miles southwest of New Orleans, Louisiana, has been geologically evaluated to determine its potential for geopressured-geothermal energy production. The structural and stratigraphic analyses were made with emphasis upon the Early and Middle Miocene age sediments which lie close to and within the geopressured section. Three geopressured sands, the Robulus (43) sand, Cibicides opima sand, and Cristellaria (I) sand, are evaluated for their potential of producing geothermal energy. Two of these sands, the Robulus (43) sand and the Cibicides opima sand, meet several of the United States Department of Energy's suggested minimum requirements for a prospective geopressured-geothermal energy reservoir.

  4. Ionizing Radiation–Inducible miR-27b Suppresses Leukemia Proliferation via Targeting Cyclin A2

    SciTech Connect (OSTI)

    Wang, Bo; Li, Dongping; Kovalchuk, Anna; Litvinov, Dmitry; Kovalchuk, Olga

    2014-09-01

    Purpose: Ionizing radiation is a common carcinogen that is important for the development of leukemia. However, the underlying epigenetic mechanisms remain largely unknown. The goal of the study was to explore microRNAome alterations induced by ionizing radiation (IR) in murine thymus, and to determine the role of IR-inducible microRNA (miRNA/miR) in the development of leukemia. Methods and Materials: We used the well-established C57BL/6 mouse model and miRNA microarray profiling to identify miRNAs that are differentially expressed in murine thymus in response to irradiation. TIB152 human leukemia cell line was used to determine the role of estrogen receptor–α (ERα) in miR-27b transcription. The biological effects of ectopic miR-27b on leukemogenesis were measured by western immunoblotting, cell viability, apoptosis, and cell cycle analyses. Results: Here, we have shown that IR triggers the differential expression of miR-27b in murine thymus tissue in a dose-, time- and sex-dependent manner. miR-27b was significantly down-regulated in leukemia cell lines CCL119 and TIB152. Interestingly, ERα was overexpressed in those 2 cell lines, and it was inversely correlated with miR-27b expression. Therefore, we used TIB152 as a model system to determine the role of ERα in miR-27b expression and the contribution of miR-27b to leukemogenesis. β-Estradiol caused a rapid and transient reduction in miR-27b expression reversed by either ERα-neutralizing antibody or ERK1/2 inhibitor. Ectopic expression of miR-27b remarkably suppressed TIB152 cell proliferation, at least in part, by inducing S-phase arrest. In addition, it attenuated the expression of cyclin A2, although it had no effect on the levels of PCNA, PPARγ, CDK2, p21, p27, p-p53, and cleaved caspase-3. Conclusion: Our data reveal that β-estradiol/ERα signaling may contribute to the down-regulation of miR-27b in acute leukemia cell lines through the ERK1/2 pathway, and that miR-27b may function as a tumor

  5. miR-208-3p promotes hepatocellular carcinoma cell proliferation and invasion through regulating ARID2 expression

    SciTech Connect (OSTI)

    Yu, Peng; Wu, Dingguo; You, Yu; Sun, Jing; Lu, Lele; Tan, Jiaxing; Bie, Ping

    2015-08-15

    MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at post-transcriptional level. miRNA dysregulation plays a causal role in cancer progression. In this study, miR-208-3p was highly expressed and directly repressed ARID2 expression. As a result, ARID2 expression in hepatocellular carcinoma (HCC) was decreased. In vitro, miR-208-3p down-regulation and ARID2 over-expression elicited similar inhibitory effects on HCC cell proliferation and invasion. In vivo test results revealed that miR-208-3p down-regulation inhibited HCC tumorigenesis in Hep3B cells. Moreover, ARID2 was possibly a downstream element of transforming growth factor beta1 (TGFβ1)/miR-208-3p/ARID2 regulatory pathway. These findings suggested that miR-208-3p up-regulation is associated with HCC cell progression and may provide a new target for liver cancer treatment. - Highlights: • miR-208-3p was highly expressed and directly repressed the expression of ARID2 in HCC. • miR-208-3p contributed to HCC cell progression both in vitro and in vivo. • Over-expression of ARID2 inhibited the HCC cell proliferation and invasion. • Restoration of ARID2 partly reversed the the effect of miR-208-3p down-regulation on HCC cells. • Newly regulatory pathway: miR-208-3p mediated the repression of ARID2 by TGFβ1 in HCC cells.

  6. Curcumin inhibits oral squamous cell carcinoma SCC-9 cells proliferation by regulating miR-9 expression

    SciTech Connect (OSTI)

    Xiao, Can; Wang, Lili; Zhu, Lifang; Zhang, Chenping; Zhou, Jianhua

    2014-11-28

    Highlights: • miR-9 expression level was significantly decreased in OSCC tissues. • Curcumin significantly inhibited SCC-9 cells proliferation. • miR-9 mediates the inhibition of SCC-9 proliferation by curcumin. • Curcumin suppresses Wnt/β-catenin signaling in SCC-9 cells. • miR-9 mediates the suppression of Wnt/β-catenin signaling by curcumin. - Abstract: Curcumin, a phytochemical derived from the rhizome of Curcuma longa, has shown anticancer effects against a variety of tumors. In the present study, we investigated the effects of curcumin on the miR-9 expression in oral squamous cell carcinoma (OSCC) and explored the potential relationships between miR-9 and Wnt/β-catenin pathway in curcumin-mediated OSCC inhibition in vitro. As the results shown, the expression levels of miR-9 were significantly lower in clinical OSCC specimens than those in the adjacent non-tumor tissues. Furthermore, our results indicated that curcumin inhibited OSCC cells (SCC-9 cells) proliferation through up-regulating miR-9 expression, and suppressing Wnt/β-catenin signaling by increasing the expression levels of the GSK-3β, phosphorylated GSK-3β and β-catenin, and decreasing the cyclin D1 level. Additionally, the up-regulation of miR-9 by curcumin in SCC-9 cells was significantly inhibited by delivering anti-miR-9 but not control oligonucleotides. Downregulation of miR-9 by anti-miR-9 not only attenuated the growth-suppressive effects of curcumin on SCC-9 cells, but also re-activated Wnt/β-catenin signaling that was inhibited by curcumin. Therefore, our findings would provide a new insight into the use of curcumin against OSCC in future.

  7. miR-339-5p inhibits alcohol-induced brain inflammation through regulating NF-κB pathway

    SciTech Connect (OSTI)

    Zhang, Yu; Wei, Guangkuan; Di, Zhiyong; Zhao, Qingjie

    2014-09-26

    Graphical abstract: - Highlights: • Alcohol upregulates miR-339-5p expression. • miR-339-5p inhibits the NF-kB pathway. • miR-339-5p interacts with and blocks activity of IKK-beat and IKK-epsilon. • miR-339-5p modulates IL-1β, IL-6 and TNF-α. - Abstract: Alcohol-induced neuroinflammation is mediated by the innate immunesystem. Pro-inflammatory responses to alcohol are modulated by miRNAs. The miRNA miR-339-5p has previously been found to be upregulated in alcohol-induced neuroinflammation. However, little has been elucidated on the regulatory functions of this miRNA in alcohol-induced neuroinflammation. We investigated the function of miR-339-5p in alcohol exposed brain tissue and isolated microglial cells using ex vivo and in vitro techniques. Our results show that alcohol induces transcription of miR 339-5p, IL-6, IL-1β and TNF-α in mouse brain tissue and isolated microglial cells by activating NF-κB. Alcohol activation of NF-κB allows for nuclear translocation of the NF-κB subunit p65 and expression of pro-inflammatory mediators. miR-339-5p inhibited expression of these pro-inflammatory factors through the NF-κB pathway by abolishing IKK-β and IKK-ε activity.

  8. Environmental Assessment -- Test Area North pool stabilization project update

    SciTech Connect (OSTI)

    1997-08-01

    The purpose of this Environmental Assessment (EA) is to update the ``Test Area North Pool Stabilization Project`` EA (DOE/EA-1050) and finding of no significant impact (FONSI) issued May 6, 1996. This update analyzes the environmental and health impacts of a drying process for the Three Mile Island (TMI) nuclear reactor core debris canisters now stored underwater in a facility on the Idaho National Engineering and Environmental Laboratory (INEEL). A drying process was analyzed in the predecision versions of the EA released in 1995 but that particular process was determined to be ineffective and dropped from the EA/FONSI issued May 6, 1996. A new drying process was subsequently developed and is analyzed in Section 2.1.2 of this document. As did the 1996 EA, this update analyzes the environmental and health impacts of removing various radioactive materials from underwater storage, dewatering these materials, constructing a new interim dry storage facility, and transporting and placing the materials into the new facility. Also, as did the 1996 EA, this EA analyzes the removal, treatment and disposal of water from the pool, and placement of the facility into a safe, standby condition. The entire action would take place within the boundaries of the INEEL. The materials are currently stored underwater in the Test Area North (TAN) building 607 pool, the new interim dry storage facility would be constructed at the Idaho Chemical Processing Plant (ICPP) which is about 25 miles south of TAN.

  9. Post Mortem of 120k mi Light-Duty Urea SCR and DPF System | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Post Mortem of 120k mi Light-Duty Urea SCR and DPF System Post Mortem of 120k mi Light-Duty Urea SCR and DPF System Presentation given at the 2007 Diesel Engine-Efficiency & Emissions Research Conference (DEER 2007). 13-16 August, 2007, Detroit, Michigan. Sponsored by the U.S. Department of Energy's (DOE) Office of FreedomCAR and Vehicle Technologies (OFCVT). deer07_lambert.pdf (649.68 KB) More Documents & Publications Urea SCR and DPF System for Tier 2 Diesel Light-Duty

  10. Port Huron, MI Liquefied Natural Gas Exports to Canada (Million Cubic Feet)

    U.S. Energy Information Administration (EIA) Indexed Site

    to Canada (Million Cubic Feet) Port Huron, MI Liquefied Natural Gas Exports to Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2013 1 2014 1 1 1 1 2 1 1 1 1 1 2015 1 1 1 1 1 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 08/31/2016 Next Release Date: 09/30/2016 Referring Pages: U.S. Liquefied Natural Gas Exports by Point of Exit Port Huron, MI Natural Gas Exports to Canad

  11. MicroRNAs expression in ox-LDL treated HUVECs: MiR-365 modulates apoptosis and Bcl-2 expression

    SciTech Connect (OSTI)

    Qin, Bing; Xiao, Bo; Liang, Desheng; Xia, Jian; Li, Ye; Yang, Huan

    2011-06-24

    Highlights: {yields} We evaluated the role of miRNAs in ox-LDL induced apoptosis in ECs. {yields} We found 4 up-regulated and 11 down-regulated miRNAs in apoptotic ECs. {yields} Target genes of the dysregulated miRNAs regulate ECs apoptosis and atherosclerosis. {yields} MiR-365 promotes ECs apoptosis via suppressing Bcl-2 expression. {yields} MiR-365 inhibitor alleviates ECs apoptosis induced by ox-LDL. -- Abstract: Endothelial cells (ECs) apoptosis induced by oxidized low-density lipoprotein (ox-LDL) is thought to play a critical role in atherosclerosis. MicroRNAs (miRNAs) are a class of noncoding RNAs that posttranscriptionally regulate the expression of genes involved in diverse cell functions, including differentiation, growth, proliferation, and apoptosis. However, whether miRNAs are associated with ox-LDL induced apoptosis and their effect on ECs is still unknown. Therefore, this study evaluated potential miRNAs and their involvement in ECs apoptosis in response to ox-LDL stimulation. Microarray and qRT-PCR analysis performed on human umbilical vein endothelial cells (HUVECs) exposed to ox-LDL identified 15 differentially expressed (4 up- and 11 down-regulated) miRNAs. Web-based query tools were utilized to predict the target genes of the differentially expressed miRNAs, and the potential target genes were classified into different function categories with the gene ontology (GO) term and KEGG pathway annotation. In particular, bioinformatics analysis suggested that anti-apoptotic protein B-cell CLL/lymphoma 2 (Bcl-2) is a target gene of miR-365, an apoptomir up-regulated by ox-LDL stimulation in HUVECs. We further showed that transfection of miR-365 inhibitor partly restored Bcl-2 expression at both mRNA and protein levels, leading to a reduction of ox-LDL-mediated apoptosis in HUVECs. Taken together, our findings indicate that miRNAs participate in ox-LDL-mediated apoptosis in HUVECs. MiR-365 potentiates ox-LDL-induced ECs apoptosis by regulating the

  12. Assessment of the Geothermal Potential Within the BPA Marketing Area.

    SciTech Connect (OSTI)

    Lund, John W.; Allen, Eliot D.

    1980-07-01

    The potential of geothermal energy is estimated that can be used for direct heat applications and electrical power generation within the Bonneville Power Administration (BPA) marketing area. The BPA marketing area includes three principal states of Oregon, Washington, and Idaho and portions of California, Montana, Wyoming, Nevada, and Utah bordering on these three states. This area covers approximately 384,000 square miles and has an estimated population of 6,760,000. The total electrical geothermal potential within this marketing area is 4077 MW/sub e/ from hydrothermal resources and 16,000 MW/sub e/ from igneous systems, whereas the total thermal (wellhead) potential is 16.15 x 10/sup 15/ Btu/y. Approximately 200 geothermal resource sites were initially identified within the BPA marketing area. This number was then reduced to about 100 sites thought to be the most promising for development by the year 2000. These 100 sites, due to load area overlap, were grouped into 53 composite sites; 21-3/4 within BPA preference customer areas and 31-1/4 within nonpreference customer areas. The geothermal resource potential was then estimated for high-temperature (> 302/sup 0/F = 150/sup 0/C), intermediate-temperature (194 to 302/sup 0/F = 90 to 150/sup 0/C), and low-temperature (< 194/sup 0/F = 90/sup 0/C) resources.

  13. MiRNA-125a-5p inhibits glioblastoma cell proliferation and promotes cell differentiation by targeting TAZ

    SciTech Connect (OSTI)

    Yuan, Jian; Xiao, Gelei; Peng, Gang; Liu, Dingyang; Wang, Zeyou; Liao, Yiwei; Liu, Qing; Wu, Minghua; Yuan, Xianrui

    2015-02-06

    Highlights: • Expression of miR-125a-5p is inversely correlated with that of TAZ in glioma cells. • MiR-125a-5p represses TAZ expression in glioma cells. • MiR-125a-5p directly targets the 3′ UTR of TAZ mRNA and promotes its degradation. • MiR-125a-5p represses CTGF and survivin via TAZ, and inhibits glioma cell growth. • MiR-125a-5p inhibits the stem cell features of HFU-251 MG cells. - Abstract: Glioblastoma (GBM) is the most lethal brain tumor due to the resistance to conventional therapies, such as radiotherapy and chemotherapy. TAZ, an important mediator of the Hippo pathway, was found to be up-regulated in diverse cancers, including in GBM, and plays important roles in tumor initiation and progression. However, little is known about the regulation of TAZ expression in tumors. In this study, we found that miR-125a-5p is an important regulator of TAZ in glioma cells by directly targeting the TAZ 3′ UTR. MiR-125a-5p levels are inversely correlated with that of TAZ in normal astrocytes and a panel of glioma cell lines. MiR-125a-5p represses the expression of TAZ target genes, including CTGF and survivin, and inhibits cell proliferation and induces the differentiation of GBM cells; whereas over-expression of TAZ rescues the effects of miR-125a-5p. This study revealed a mechanism for TAZ deregulation in glioma cells, and also demonstrated a tumor suppressor role of miR-125a-5p in glioblastoma cells.

  14. DOE Zero Energy Ready Home Case Study: Cobblestone Homes, Midland, MI

    Broader source: Energy.gov [DOE]

    Case study of a DOE Zero Energy Ready home in Midland, MI, that scored HERS 49 without PV or HERS 44 with 1.4 kW of PV. The custom home served as a prototype and energy efficiency demonstration...

  15. The NuMI proton beam at Fermilab successes and challenges

    SciTech Connect (OSTI)

    Childress, S.; /Fermilab

    2008-11-01

    The NuMI beam at Fermilab has delivered over 5 x 10{sup 20} 120 GeV protons to the neutrino production target since the start for MINOS [1] neutrino oscillation experiment operation in 2005. We report on proton beam commissioning and operation status, including successes and challenges with this beam.

  16. MiR-18a regulates the proliferation, migration and invasion of human glioblastoma cell by targeting neogenin

    SciTech Connect (OSTI)

    Song, Yichen; Wang, Ping; Zhao, Wei; Yao, Yilong; Liu, Xiaobai; Ma, Jun; Xue, Yixue; Liu, Yunhui

    2014-05-15

    MiR-17-92 cluster has recently been reported as an oncogene in some tumors. However, the association of miR-18a, an important member of this cluster, with glioblastoma remains unknown. Therefore, this study aims to investigate the expression of miR-18a in glioblastoma and its role in biological behavior of U87 and U251 human glioblastoma cell lines. Quantitative RT-PCR results showed that miR-18a was highly expressed in glioblastoma tissues and U87 and U251 cell lines compared with that in human brain tissues and primary normal human astrocytes, and the expression levels were increased along with the rising pathological grades of glioblastoma. Neogenin was identified as the target gene of miR-18a by dual-luciferase reporter assays. RT-PCR and western blot results showed that its expression levels were decreased along with the rising pathological grades of glioblastoma. Inhibition of miR-18a expression was established by transfecting exogenous miR-18a inhibitor into U87 and U251 cells, and its effects on the biological behavior of glioblastoma cells were studied using CCK-8 assay, transwell assay and flow cytometry. Inhibition of miR-18a expression in U87 and U251 cells significantly up-regulated neogenin, and dramatically suppressed the abilities of cell proliferation, migration and invasion, induced cell cycle arrest and promoted cellular apoptosis. Collectively, these results suggest that miR-18a may regulate biological behavior of human glioblastoma cells by targeting neogenin, and miR-18a can serve as a potential target in the treatment of glioblastoma. - Highlights: • MiR-18a was highly expressed in glioblastoma tissues and U87 and U251 cell lines. • Neogenin was identified as the target gene of miR-18a. • Neogenin expressions were decreased along with the rising pathological grades of glioblastoma. • Inhibition of miR-18a suppressed biological behavior of glioma cells by up-regulating neogenin.

  17. Marysville, MI Natural Gas Imports by Pipeline from Canada

    Gasoline and Diesel Fuel Update (EIA)

    Monthly Annual Download Series History Download Series History Definitions, Sources & Notes Definitions, Sources & Notes Show Data By: Data Series Area 2010 2011 2012 2013 2014 2015 View History Pipeline Volumes 5,694 9,946 8,099 2,337 4,650 1,961 1996-2015 Pipeline Prices 4.44 4.42 2.99 4.15 6.86 2.73 1996-2015

  18. EIS-0402: Remediation of Area IV of the Santa Susana Field Laboratory, California

    Broader source: Energy.gov [DOE]

    DOE is preparing an EIS for cleanup of Area IV, including the Energy Technology Engineering Center (ETEC), as well as the Northern Buffer Zone of the Santa Susana Field Laboratory (SSFL) in eastern Ventura County, California, approximately 29 miles north of downtown Los Angeles. (DOE’s operations bordered the Northern Buffer Zone. DOE is responsible for soil cleanup in Area IV and the Northern Buffer Zone.) In the EIS, DOE will evaluate reasonable alternatives for disposition of radiological facilities and support buildings, remediation of contaminated soil and groundwater, and disposal of all resulting waste at permitted facilities.

  19. miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer

    SciTech Connect (OSTI)

    Li, Qiaoyan; Zhu, Fufan; Chen, Puxiang

    2012-07-20

    Highlights: Black-Right-Pointing-Pointer Both miR-7 and miR-218 down-regulates HoxB3 expression by targeting the 3 Prime -UTR of HoxB3 mRNA. Black-Right-Pointing-Pointer A reverse correlation between the levels of endogenous miR-7, miR218 and HoxB3 expression. Black-Right-Pointing-Pointer Epigenetic changes involve in the reactivation of HoxB3. Black-Right-Pointing-Pointer Both miRNAs inhibits the cell cycle and clone formation of breast cancer cells. -- Abstract: Many microRNAs have been implicated as key regulators of cellular growth and differentiation and have been found to dysregulate proliferation in human tumors, including breast cancer. Cancer-linked microRNAs also alter the epigenetic landscape by way of DNA methylation and post-translational modifications of histones. Aberrations in Hox gene expression are important for oncogene or tumor suppressor during abnormal development and malignancy. Although recent studies suggest that HoxB3 is critical in breast cancer, the putative role(s) of microRNAs impinging on HoxB3 is not yet fully understood. In this study, we found that the expression levels of miR-7 and miR-218 were strongly and reversely associated with HoxB3 expression. Stable overexpression of miR-7 and miR-218 was accompanied by reactivation of tumor suppressor genes including RASSF1A and Claudin-6 by means of epigenetic switches in DNA methylation and histone modification, giving rise to inhibition of the cell cycle and clone formation of breast cancer cells. The current study provides a novel link between overexpression of collinear Hox genes and multiple microRNAs in human breast malignancy.

  20. Re-evaluation of Spent Nuclear Fuel Assay Data for the Three Mile Island Unit 1 Reactor and Application to Code Validation

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Gauld, Ian C.; Giaquinto, J. M.; Delashmitt, J. S.; Hu, Jianwei; Ilas, Germina; Haverlock, T. J.; Romano, Catherine E.

    2016-01-01

    Destructive radiochemical assay measurements of spent nuclear fuel rod segments from an assembly irradiated in the Three Mile Island unit 1 (TMI-1) pressurized water reactor have been performed at Oak Ridge National Laboratory (ORNL). Assay data are reported for five samples from two fuel rods of the same assembly. The TMI-1 assembly was a 15 X 15 design with an initial enrichment of 4.013 wt% 235U, and the measured samples achieved burnups between 45.5 and 54.5 gigawatt days per metric ton of initial uranium (GWd/t). Measurements were performed mainly using inductively coupled plasma mass spectrometry after elemental separation via highmore » performance liquid chromatography. High precision measurements were achieved using isotope dilution techniques for many of the lanthanides, uranium, and plutonium isotopes. Measurements are reported for more than 50 different isotopes and 16 elements. One of the two TMI-1 fuel rods measured in this work had been measured previously by Argonne National Laboratory (ANL), and these data have been widely used to support code and nuclear data validation. Recently, ORNL provided an important opportunity to independently cross check results against previous measurements performed at ANL. The measured nuclide concentrations are used to validate burnup calculations using the SCALE nuclear systems modeling and simulation code suite. These results show that the new measurements provide reliable benchmark data for computer code validation.« less

  1. Re-evaluation of Spent Nuclear Fuel Assay Data for the Three Mile Island Unit 1 Reactor and Application to Code Validation

    SciTech Connect (OSTI)

    Gauld, Ian C.; Giaquinto, J. M.; Delashmitt, J. S.; Hu, Jianwei; Ilas, Germina; Haverlock, T. J.; Romano, Catherine E.

    2016-01-01

    Destructive radiochemical assay measurements of spent nuclear fuel rod segments from an assembly irradiated in the Three Mile Island unit 1 (TMI-1) pressurized water reactor have been performed at Oak Ridge National Laboratory (ORNL). Assay data are reported for five samples from two fuel rods of the same assembly. The TMI-1 assembly was a 15 X 15 design with an initial enrichment of 4.013 wt% 235U, and the measured samples achieved burnups between 45.5 and 54.5 gigawatt days per metric ton of initial uranium (GWd/t). Measurements were performed mainly using inductively coupled plasma mass spectrometry after elemental separation via high performance liquid chromatography. High precision measurements were achieved using isotope dilution techniques for many of the lanthanides, uranium, and plutonium isotopes. Measurements are reported for more than 50 different isotopes and 16 elements. One of the two TMI-1 fuel rods measured in this work had been measured previously by Argonne National Laboratory (ANL), and these data have been widely used to support code and nuclear data validation. Recently, ORNL provided an important opportunity to independently cross check results against previous measurements performed at ANL. The measured nuclide concentrations are used to validate burnup calculations using the SCALE nuclear systems modeling and simulation code suite. These results show that the new measurements provide reliable benchmark data for computer code validation.

  2. PSMB4 promotes multiple myeloma cell growth by activating NF-κB-miR-21 signaling

    SciTech Connect (OSTI)

    Zheng, Peihao; Guo, Honggang; Li, Guangchao; Han, Siqi; Luo, Fei; Liu, Yi

    2015-03-06

    Proteasomal subunit PSMB4, was recently identified as potential cancer driver genes in several tumors. However, the regulatory mechanism of PSMB4 on carcinogenesis process remains unclear. In this study, we investigated the expression and roles of PSMB4 in multiple myeloma (MM). We found a significant up-regulation of PSMB4 in MM plasma and cell lines. Ectopic overexpression of PSMB4 promoted cell growth and colony forming ability of MM cells, whereas inhibition of PSMB4 led to a decrease of such events. Furthermore, our results demonstrated the up-regulation of miR-21 and a positive correlation between the levels of miR-21 and PSMB4 in MM. Re-expression of miR-21 markedly rescued PSMB4 knockdown-mediated suppression of cell proliferation and clone-formation. Additionally, while enforced expression of PSMB4 profoundly increased NF-κB activity and the level of miR-21, PSMB4 knockdown or NF-κB inhibition suppressed miR-21 expression in MM cells. Taken together, our results demonstrated that PSMB4 regulated MM cell growth in part by activating NF-κB-miR-21 signaling, which may represent promising targets for novel specific therapies. - Highlights: • First reported upregulation of PSMB4 in MM plasma and cell lines. • PSMB4 promoted MM cell growth and colony forming ability. • Further found miR-21 was up-regulated by PSMB4 in MM plasma and cell lines. • PSMB4-induced miR-21 expression was modulated by NF-κB. • PSMB4-NF-κB-miR-21 axis may be potential therapeutic targets of MM.

  3. 300 Area - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    300 Area 324 Building 325 Building 400 AreaFast Flux Test Facility 618-10 and 618-11 Burial Grounds 700 Area B Plant B Reactor C Reactor Canister Storage Building and Interim ...

  4. 200 Area - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    300 Area 324 Building 325 Building 400 AreaFast Flux Test Facility 618-10 and 618-11 Burial Grounds 700 Area B Plant B Reactor C Reactor Canister Storage Building and Interim ...

  5. 700 Area - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    300 Area 324 Building 325 Building 400 AreaFast Flux Test Facility 618-10 and 618-11 Burial Grounds 700 Area B Plant B Reactor C Reactor Canister Storage Building and Interim ...

  6. Sweet Surface Area

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sweet Surface Area Sweet Surface Area Create a delicious root beer float and learn sophisticated science concepts at the same time. Sweet Surface Area Science is all around us, so ...

  7. Soda Lake Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    of Reservoir: 1219 m1.219 km 0.757 mi 3,999.344 ft 1,333.111 yd 1 Average Depth to Reservoir: 762 m0.762 km 0.473 mi 2,500 ft 833.331 yd Use the "Edit with Form" button at...

  8. Strategic Focus Areas

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Strategic Focus Areas Lockheed Martin on behalf of Sandia National Laboratories will consider grant requests that best support the Corporation's strategic focus areas and reflect ...

  9. AREA 5 RWMS CLOSURE

    National Nuclear Security Administration (NNSA)

    153 CLOSURE STRATEGY NEVADA TEST SITE AREA 5 RADIOACTIVE WASTE MANAGEMENT SITE Revision 0 ... Closure Strategy Nevada Test Site Area 5 Radioactive Waste Management ...

  10. Aryl hydrocarbon receptor-dependent regulation of miR-196a expression controls lung fibroblast apoptosis but not proliferation

    SciTech Connect (OSTI)

    Hecht, Emelia; Zago, Michela; Sarill, Miles; Rico de Souza, Angela; Gomez, Alvin; Matthews, Jason; Hamid, Qutayba; Eidelman, David H.; Baglole, Carolyn J.

    2014-11-01

    The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor implicated in the regulation of apoptosis and proliferation. Although activation of the AhR by xenobiotics such as dioxin inhibits the cell cycle and control apoptosis, paradoxically, AhR expression also promotes cell proliferation and survival independent of exogenous ligands. The microRNA (miRNA) miR-196a has also emerged as a regulator of proliferation and apoptosis but a relationship between the AhR and miR-196a is not known. Therefore, we hypothesized that AhR-dependent regulation of endogenous miR-196a expression would promote cell survival and proliferation. Utilizing lung fibroblasts from AhR deficient (AhR{sup −/−}) and wild-type (AhR{sup +/+}) mice, we show that there is ligand-independent regulation of miRNA, including low miR-196a in AhR{sup −/−} cells. Validation by qRT-PCR revealed a significant decrease in basal expression of miR-196a in AhR{sup −/−} compared to AhR{sup +/+} cells. Exposure to AhR agonists benzo[a]pyrene (B[a]P) and FICZ as well as AhR antagonist CH-223191 decreased miR-196a expression in AhR{sup +/+} fibroblasts concomitant with decreased AhR protein levels. There was increased proliferation only in AhR{sup +/+} lung fibroblasts in response to serum, corresponding to a decrease in p27{sup KIP1} protein, a cyclin-dependent kinase inhibitor. Increasing the cellular levels of miR-196a had no effect on proliferation or expression of p27{sup KIP1} in AhR{sup −/−} fibroblasts but attenuated cigarette smoke-induced apoptosis. This study provides the first evidence that AhR expression is essential for the physiological regulation of cellular miRNA levels- including miR-196a. Future experiments designed to elucidate the functional relationship between the AhR and miR-196a may delineate additional novel ligand-independent roles for the AhR. - Highlights: • The AhR controls proliferation and apoptosis in lung cells. • The AhR regulates the

  11. RLIP76-dependent suppression of PI3K/AKT/Bcl-2 pathway by miR...

    Office of Scientific and Technical Information (OSTI)

    in prostate cancer Citation Details In-Document Search Title: RLIP76-dependent suppression of PI3KAKTBcl-2 pathway by miR-101 induces apoptosis in prostate cancer MicroRNA-101 ...

  12. Material Activation Benchmark Experiments at the NuMI Hadron Absorber Hall in Fermilab

    SciTech Connect (OSTI)

    Matsumura, H.; Matsuda, N.; Kasugai, Y.; Toyoda, A.; Yashima, H.; Sekimoto, S.; Iwase, H.; Oishi, K.; Sakamoto, Y.; Nakashima, H.; Leveling, A.; Boehnlein, D.; Lauten, G.; Mokhov, N.; Vaziri, K.

    2014-06-15

    In our previous study, double and mirror symmetric activation peaks found for Al and Au arranged spatially on the back of the Hadron absorber of the NuMI beamline in Fermilab were considerably higher than those expected purely from muon-induced reactions. From material activation bench-mark experiments, we conclude that this activation is due to hadrons with energy greater than 3 GeV that had passed downstream through small gaps in the hadron absorber.

  13. Port Huron, MI Natural Gas Pipeline Imports From Canada (Million Cubic

    U.S. Energy Information Administration (EIA) Indexed Site

    Feet) Million Cubic Feet) Port Huron, MI Natural Gas Pipeline Imports From Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2016 262 278 16 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 08/31/2016 Next Release Date: 09/30/2016 Referring Pages: U.S.

  14. miR-21 modulates tumor outgrowth induced by human adipose tissue-derived mesenchymal stem cells in vivo

    SciTech Connect (OSTI)

    Shin, Keun Koo; Lee, Ae Lim; Kim, Jee Young; Medical Research Center for Ischemic Tissue Engineering, Pusan National University, Yangsan, Gyeongnam 626-870; BK21 Medical Science Education Center, School of Medicine, Pusan National University, Yangsan, Gyeongnam 626-870 ; Lee, Sun Young; Medical Research Center for Ischemic Tissue Engineering, Pusan National University, Yangsan, Gyeongnam 626-870 ; Bae, Yong Chan; Jung, Jin Sup

    2012-06-15

    Highlights: Black-Right-Pointing-Pointer miR-21 modulates hADSC-induced increase of tumor growth. Black-Right-Pointing-Pointer The action is mostly mediated by the modulation of TGF-{beta} signaling. Black-Right-Pointing-Pointer Inhibition of miR-21 enhances the blood flow recovery in hindlimb ischemia. -- Abstract: Mesenchymal stem cells (MSCs) have generated a great deal of interest in clinical situations, due principally to their potential use in regenerative medicine and tissue engineering applications. However, the therapeutic application of MSCs remains limited, unless the favorable effects of MSCs on tumor growth in vivo, and the long-term safety of the clinical applications of MSCs, can be more thoroughly understood. In this study, we determined whether microRNAs can modulate MSC-induced tumor outgrowth in BALB/c nude mice. Overexpression of miR-21 in human adipose-derived stem cells (hADSCs) inhibited hADSC-induced tumor growth, and inhibition of miR-21 increased it. Downregulation of transforming growth factor beta receptor II (TGFBR2), but not of signal transducer and activator of transcription 3, in hADSCs showed effects similar to those of miR-21 overexpression. Downregulation of TGFBR2 and overexpression of miR21 decreased tumor vascularity. Inhibition of miR-21 and the addition of TGF-{beta} increased the levels of vascular endothelial growth factor and interleukin-6 in hADSCs. Transplantation of miR-21 inhibitor-transfected hADSCs increased blood flow recovery in a hind limb ischemia model of nude mice, compared with transplantation of control oligo-transfected cells. These findings indicate that MSCs might favor tumor growth in vivo. Thus, it is necessary to study the long-term safety of this technique before MSCs can be used as therapeutic tools in regenerative medicine and tissue engineering.

  15. Targeting miR-21 enhances the sensitivity of human colon cancer HT-29 cells to chemoradiotherapy in vitro

    SciTech Connect (OSTI)

    Deng, Jun; Lei, Wan; Fu, Jian-Chun; Zhang, Ling; Li, Jun-He; Xiong, Jian-Ping

    2014-01-17

    Highlight: MiR-21 plays a significant role in 5-FU resistance. This role might be attributed to targeting of hMSH2 as well as TP and DPD via miR-21 targeted hMSH2. Indirectly targeted TP and DPD to influence 5-FU chemotherapy sensitivity. -- Abstract: 5-Fluorouracil (5-FU) is a classic chemotherapeutic drug that has been widely used for colorectal cancer treatment, but colorectal cancer cells are often resistant to primary or acquired 5-FU therapy. Several studies have shown that miR-21 is significantly elevated in colorectal cancer. This suggests that this miRNA might play a role in this resistance. In this study, we investigated this possibility and the possible mechanism underlying this role. We showed that forced expression of miR-21 significantly inhibited apoptosis, enhanced cell proliferation, invasion, and colony formation ability, promoted G1/S cell cycle transition and increased the resistance of tumor cells to 5-FU and X radiation in HT-29 colon cancer cells. Furthermore, knockdown of miR-21 reversed these effects on HT-29 cells and increased the sensitivity of HT-29/5-FU to 5-FU chemotherapy. Finally, we showed that miR-21 targeted the human mutS homolog2 (hMSH2), and indirectly regulated the expression of thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD). These results demonstrate that miR-21 may play an important role in the 5-FU resistance of colon cancer cells.

  16. Measurement of Pi-K Ratios from the NuMI Target

    SciTech Connect (OSTI)

    Seun, Sin Man; /Harvard U.

    2007-07-01

    Interactions of protons (p) with the NuMI (Neutrinos at the Main Injector) target are used to create the neutrino beam for the MINOS (Main Injector Neutrino Oscillation Search) Experiment. Using the MIPP (Main Injector Particle Production) experimental apparatus, the production of charged pions and kaons in p+NuMI interactions is studied. The data come from a sample of 2 x 10{sup 6} events obtained by MIPP using the 120 GeV/c proton beam from the Main Injector at Fermi National Accelerator Laboratory in Illinois, USA. Pions and kaons are identified by measurement in a Ring Imaging Cherenkov detector. Presented are measurements of {pi}{sup -}/{pi}{sup +}, K{sup -}/K{sup +}, {pi}{sup +}/K{sup +} and {pi}{sup -}/K{sup -} production ratios in the momentum range p{sub T} < 2 GeV/c transversely and 20 GeV/c < p{sub z} < 90 GeV/c longitudinally. Also provided are detailed comparisons of the MIPP NuMI data with the MIPP Thin Carbon data, the MIPP Monte Carlo simulation and the current MINOS models in the relevant momentum ranges.

  17. 100 Area - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    00 Area About Us About Hanford Cleanup Hanford History Hanford Site Wide Programs Contact Us 100 Area 118-K-1 Burial Ground 200 Area 222-S Laboratory 242-A Evaporator 300 Area 324 Building 325 Building 400 Area/Fast Flux Test Facility 618-10 and 618-11 Burial Grounds 700 Area B Plant B Reactor C Reactor Canister Storage Building and Interim Storage Area Canyon Facilities Cold Test Facility D and DR Reactors Effluent Treatment Facility Environmental Restoration Disposal Facility F Reactor H

  18. miR-502 inhibits cell proliferation and tumor growth in hepatocellular carcinoma through suppressing phosphoinositide 3-kinase catalytic subunit gamma

    SciTech Connect (OSTI)

    Chen, Suling; Li, Fang; Chai, Haiyun; Tao, Xin; Wang, Haili; Ji, Aifang

    2015-08-21

    MicroRNAs (miRNAs) play a key role in carcinogenesis and tumor progression in hepatocellular carcinoma (HCC). In the present study, we demonstrated that miR-502 significantly inhibits HCC cell proliferation in vitro and tumor growth in vivo. G1/S cell cycle arrest and apoptosis of HCC cells were induced by miR-502. Phosphoinositide 3-kinase catalytic subunit gamma (PIK3CG) was identified as a direct downstream target of miR-502 in HCC cells. Notably, overexpression of PIK3CG reversed the inhibitory effects of miR-502 in HCC cells. Our findings suggest that miR-502 functions as a tumor suppressor in HCC via inhibition of PI3KCG, supporting its utility as a promising therapeutic gene target for this tumor type. - Highlights: • miR-502 suppresses HCC cell proliferation in vitro and tumorigenicity in vivo. • miR-502 regulates cell cycle and apoptosis in HCC cells. • PIK3CG is a direct target of miR-502. • miR-502 and PIK3CG expression patterns are inversely correlated in HCC tissues.

  19. Closure report for CAU No. 416: Project Shoal Area

    SciTech Connect (OSTI)

    1998-01-01

    This Closure Report provides the documentation for closure of the US Department of Energy/Nevada Operations Office (DOE/NV) Project Shoal Area (PSA) Surface Corrective Action Unit (CAU) 416. CAU 416 consists of a mud pit, muckpile, and housekeeping site. The PSA is located approximately 48.3 kilometers (30 miles) southeast of Fallon, Nevada. The mud pit was the result of drilling activities at the PSA in 1963. Investigation activities completed in 1996 determined drilling mud in the mud pit was impacted with petroleum hydrocarbons in excess of the State of Nevada 100 milligram per kilogram (mg/kg). The muckpile consists of broken granite from emplacement shaft and drift (tunnel) mining activities at the PSA in 1963. The housekeeping site consisted of approximately 20 used, empty, rusted, steel 0.9 liter (1 quart) oil cans.

  20. Closure Strategy Nevada Test Site Area 5 Radioactive Waste Management Site

    SciTech Connect (OSTI)

    NSTec Environmental Management

    2007-03-01

    This paper presents an overview of the strategy for closure of part of the Area 5 Radioactive Waste Management Site (RWMS) at the Nevada Test Site (NTS), which is about 65 miles northwest of Las Vegas, Nevada (Figure 1). The Area 5 RWMS is in the northern part of Frenchman Flat, approximately 14 miles north of Mercury. The Area 5 RWMS encompasses 732 acres subdivided into quadrants, and is bounded by a 1,000-foot (ft)-wide buffer zone. The northwest and southwest quadrants have not been developed. The northeast and southeast quadrants have been used for disposal of unclassified low-level radioactive waste (LLW) and indefinite storage of classified materials. This paper focuses on closure of the 38 waste disposal and classified material storage units within the southeast quadrant of the Area 5 RWMS, called the ''92-Acre Area''. The U.S Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (NNSA/NSO) is currently planning to close the 92-Acre Area by 2011. Closure planning for this site must take into account the regulatory requirements for a diversity of waste streams, disposal and storage configurations, disposal history, and site conditions. For ease of discussion, the 92-Acre Area has been subdivided into six closure units defined by waste type, location, and similarity in regulatory requirements. Each of the closure units contains one or more waste disposal units; waste disposal units are also called waste disposal cells. The paper provides a brief background of the Area 5 RWMS, identifies key closure issues for the 92-Acre Area, recommends actions to address the issues, and provides the National Security Technologies, LLC (NSTec), schedule for closure.

  1. PREFERRED WATERFLOOD MANAGEMENT PRACTICES FOR THE SPRABERRY TREND AREA

    SciTech Connect (OSTI)

    David S. Schechter

    2004-08-31

    The naturally fractured Spraberry Trend Area is one of the largest reservoirs in the domestic U.S. and is the largest reservoir in area extent in the world. Production from Spraberry sands is found over a 2,500 sq. mile area and Spraberry reservoirs can be found in an eight county area in west Texas. Over 150 operators produce 65,000 barrels of oil per day (bopd) from the Spraberry Trend Area from more than 9,000 production wells. Recovery is poor, on the order of 7-10% due to the profoundly complicated nature of the reservoir, yet billions of barrels of hydrocarbons remain. We estimate over 15% of remaining reserves in domestic Class III reservoirs are in Spraberry Trend Area reservoirs. This tremendous domestic asset is a prime example of an endangered hydrocarbon resource in need of immediate technological advancements before thousands of wells are permanently abandoned. This report describes the final work of the project, ''Preferred Waterflood Management Practices for the Spraberry Trend Area.'' The objective of this project is to significantly increase field-wide production in the Spraberry Trend in a short time frame through the application of preferred practices for managing and optimizing water injection. Our goal is to dispel negative attitudes and lack of confidence in water injection and to document the methodology and results for public dissemination to motivate waterflood expansion in the Spraberry Trend. This objective has been accomplished through research in three areas: (1) detail historical review and extensive reservoir characterization, (2) production data management, and (3) field demonstration. This provides results of the final year of the three-year project for each of the three areas.

  2. MiR-145 is downregulated in human ovarian cancer and modulates cell growth and invasion by targeting p70S6K1 and MUC1

    SciTech Connect (OSTI)

    Wu, Huijuan; Xiao, ZhengHua; Wang, Ke; Liu, Wenxin; Hao, Quan

    2013-11-29

    Highlights: MiR-145 is downregulated in human ovarian cancer. MiR-145 targets p70S6K1 and MUC1. p70S6K1 and MUC1 are involved in miR-145 mediated tumor cell growth and cell invasion, respectively. -- Abstract: MicroRNAs (miRNAs) are a family of small non-coding RNA molecules that regulate gene expression at post-transcriptional levels. Previous studies have shown that miR-145 is downregulated in human ovarian cancer; however, the roles of miR-145 in ovarian cancer growth and invasion have not been fully demonstrated. In the present study, Northern blot and qRT-PCR analysis indicate that miR-145 is downregulated in ovarian cancer tissues and cell lines, as well as in serum samples of ovarian cancer, compared to healthy ovarian tissues, cell lines and serum samples. Functional studies suggest that miR-145 overexpression leads to the inhibition of colony formation, cell proliferation, cell growth viability and invasion, and the induction of cell apoptosis. In accordance with the effect of miR-145 on cell growth, miR-145 suppresses tumor growth in vivo. MiR-145 is found to negatively regulate P70S6K1 and MUC1 protein levels by directly targeting their 3?UTRs. Importantly, the overexpression of p70S6K1 and MUC1 can restore the cell colony formation and invasion abilities that are reduced by miR-145, respectively. MiR-145 expression is increased after 5-aza-CdR treatment, and 5-aza-CdR treatment results in the same phenotype as the effect of miR-145 overexpression. Our study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1, functioning as a tumor suppressor. Moreover, our data imply that miR-145 has potential as a miRNA-based therapeutic target for ovarian cancer.

  3. Technical Area 21

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Technical Area 21 Technical Area 21 Technical Area 21 was the site of chemical research for refining plutonium and plutonium metal production from 1945 to 1978. August 1, 2013 Technical Area 21 in 2011 Technical Area 21 in 2011 Technical Area 21 (TA-21), also known as DP Site was the site of chemical research for refining plutonium and plutonium metal production from 1945 to 1978. Between 2008 and 2011, MDAs B, U, and V were excavated and removed. 24 buildings were demolished in 2010 and 2011

  4. Geothermal resource assessment of the Yucca Mountain Area, Nye County, Nevada. Final report

    SciTech Connect (OSTI)

    Flynn, T.; Buchanan, P.; Trexler, D.; Shevenell, L., Garside, L.

    1995-12-01

    An assessment of the geothermal resources within a fifty-mile radius of the Yucca Mountain Project area was conducted to determine the potential for commercial development. The assessment includes collection, evaluation, and quantification of existing geological, geochemical, hydrological, and geophysical data within the Yucca Mountain area as they pertain to geothermal phenomena. Selected geologic, geochemical, and geophysical data were reduced to a set of common-scale digital maps using Geographic Information Systems (GIS) for systematic analysis and evaluation. Available data from the Yucca Mountain area were compared to similar data from developed and undeveloped geothermal areas in other parts of the Great Basin to assess the resource potential for future geothermal development at Yucca Mountain. This information will be used in the Yucca Mountain Site Characterization Project to determine the potential suitability of the site as a permanent underground repository for high-level nuclear waste.

  5. Site Monitoring Area Maps

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Maps Individual Permit: Site Monitoring Area Maps Each Site Monitoring Area Map is updated whenever the map information is updated. Contact Environmental Communication & Public Involvement P.O. Box 1663 MS M996 Los Alamos, NM 87545 (505) 667-0216 Email What do these maps show? The Individual Permit for Storm Water site monitoring area maps display the following information: Surface hydrological features Locations of the Site(s) assigned to the Site Monitoring Area (SMA) The Site Monitoring

  6. Conceptual Model At Valles Caldera - Redondo Geothermal Area...

    Open Energy Info (EERE)

    extending to the AET-4 well near Jemez Springs. References Lisa Shevenell, Fraser E. Goff, Dan Miles, Al Waibel, Chandler Swanberg (1988) Lithologic Descriptions and Temperature...

  7. Well Log Data At Valles Caldera - Redondo Geothermal Area (Shevenell...

    Open Energy Info (EERE)

    extending to the AET-4 well near Jemez Springs. References Lisa Shevenell, Fraser E. Goff, Dan Miles, Al Waibel, Chandler Swanberg (1988) Lithologic Descriptions and Temperature...

  8. Observation Wells At Fenton Hill HDR Geothermal Area (Shevenell...

    Open Energy Info (EERE)

    the hydrothermal outflow plume issuing from the western margin of the Valles caldera (Goff et al., 1988). References Lisa Shevenell, Fraser E. Goff, Dan Miles, Al Waibel,...

  9. Testing CPT conservation using the NuMI neutrino beam with the MINOS experiment

    SciTech Connect (OSTI)

    Auty, David John

    2010-05-01

    The MINOS experiment was designed to measure neutrino oscillation parameters with muon neutrinos. It achieves this by measuring the neutrino energy spectrum and flavor composition of the man-made NuMI neutrino beam 1km after the beam is formed and again after 735 km. By comparing the two spectra it is possible to measure the oscillation parameters. The NuMI beam is made up of 7.0% {bar {nu}}{sub {mu}}, which can be separated from the {nu}{sub {mu}} because the MINOS detectors are magnetized. This makes it possible to study {bar {nu}}{sub {mu}} oscillations separately from those of muon neutrinos, and thereby test CPT invariance in the neutrino sector by determining the {bar {nu}}{sub {mu}} oscillation parameters and comparing them with those for {nu}{sub {mu}}, although any unknown physics of the antineutrino would appear as a difference in oscillation parameters. Such a test has not been performed with beam {bar {nu}}{sub {mu}} before. It is also possible to produce an almost pure {bar {nu}}{sub {mu}} beam by reversing the current through the magnetic focusing horns of the NuMI beamline, thereby focusing negatively, instead of positively charged particles. This thesis describes the analysis of the 7% {bar {nu}}{sub {mu}} component of the forward horn current NuMI beam. The {bar {nu}}{sub {mu}} of a data sample of 3.2 x 10{sup 20} protons on target analysis found 42 events, compared to a CPT conserving prediction of 58.3{sub -7.6}{sup +7.6}(stat.){sub -3.6}{sup +3.6}(syst.) events. This corresponds to a 1.9 {sigma} deficit, and a best fit value of {Delta}{bar m}{sub 32}{sup 2} = 18 x 10{sup -3} eV{sup 2} and sin{sup 2} 2{bar {theta}}{sub 23} = 0.55. This thesis focuses particularly on the selection of {bar {nu}}{sub {mu}} events, and investigates possible improvements of the selection algorithm. From this a different selector was chosen, which corroborated the findings of the original selector. The thesis also investigates how the systematic errors affect the

  10. DOE Zero Ready Home Case Study: Cobblestone Homes, 2014 Model Home, Midland, MI

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Cobblestone Homes 2014 Model Home Midland, MI DOE ZERO ENERGY READY HOME(tm) The U.S. Department of Energy invites home builders across the country to meet the extraordinary levels of excellence and quality specified in DOE's Zero Energy Ready Home program (formerly known as Challenge Home). Every DOE Zero Energy Ready Home starts with ENERGY STAR Certified Homes Version 3.0 for an energy-efficient home built on a solid foundation of building science research. Advanced technologies are designed

  11. Port Huron, MI Natural Gas Pipeline Imports From Canada (Dollars per

    U.S. Energy Information Administration (EIA) Indexed Site

    Thousand Cubic Feet) Dollars per Thousand Cubic Feet) Port Huron, MI Natural Gas Pipeline Imports From Canada (Dollars per Thousand Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2016 2.07 2.06 2.21 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 08/31/2016 Next Release Date: 09/30/2016 Referring Pages: U.S. Price of

  12. miR-340 inhibits glioblastoma cell proliferation by suppressing CDK6, cyclin-D1 and cyclin-D2

    SciTech Connect (OSTI)

    Li, Xuesong; Gong, Xuhai; Chen, Jing; Zhang, Jinghui; Sun, Jiahang; Guo, Mian

    2015-05-08

    Glioblastoma development is often associated with alteration in the activity and expression of cell cycle regulators, such as cyclin-dependent kinases (CKDs) and cyclins, resulting in aberrant cell proliferation. Recent studies have highlighted the pivotal roles of miRNAs in controlling the development and growth of glioblastoma. Here, we provide evidence for a function of miR-340 in the inhibition of glioblastoma cell proliferation. We found that miR-340 is downregulated in human glioblastoma tissue samples and several established glioblastoma cell lines. Proliferation and neurosphere formation assays revealed that miR-340 plays an oncosuppressive role in glioblastoma, and that its ectopic expression causes significant defect in glioblastoma cell growth. Further, using bioinformatics, luciferase assay and western blot, we found that miR-340 specifically targets the 3′UTRs of CDK6, cyclin-D1 and cyclin-D2, leading to the arrest of glioblastoma cells in the G0/G1 cell cycle phase. Confirming these results, we found that re-introducing CDK6, cyclin-D1 or cyclin-D2 expression partially, but significantly, rescues cells from the suppression of cell proliferation and cell cycle arrest mediated by miR-340. Collectively, our results demonstrate that miR-340 plays a tumor-suppressive role in glioblastoma and may be useful as a diagnostic biomarker and/or a therapeutic avenue for glioblastoma. - Highlights: • miR-340 is downregulated in glioblastoma samples and cell lines. • miR-340 inhibits glioblastoma cell proliferation. • miR-340 directly targets CDK6, cyclin-D1, and cyclin-D2. • miR-340 regulates glioblastoma cell proliferation via CDK6, cyclin-D1 and cyclin-D2.

  13. Inner Area Principles

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Inner Area Principles The Inner Area principles proposed by the Tri-Parties are a good beginning toward consideration of what kind of approach will be needed to remedy the problems of the Central Plateau. However, the Board feels that some principles have been overlooked in the preparation of these. [1] While it has been generally agreed that designated waste disposal facilities of the Inner Area (like ERDF and IDF) would not be candidates for remediation. What happened to the remedial approach

  14. Assessment of radiological releases from the NuMI facility during MINOS and NOvA operations

    SciTech Connect (OSTI)

    Martens, Mike; /Fermilab

    2007-04-01

    This report makes projections of the radiological releases from the NuMI facility during operations for the MINOS and NO ?A experiments. It includes an estimate of the radionuclide levels released into the atmosphere and the estimated tritium and sodium-22 concentrations in the NuMI sump water and Fermilab pond system. The analysis was performed for NuMI operations with a beam power on target increased from the present 400 kW design up to a possible 1500 kW with future upgrades. The total number of protons on target was assumed to be 18 x 10{sup 20} after the completion of MINOS and 78 x 10{sup 20} after the completion of NO ?A.

  15. Imperial Valley Geothermal Area

    Broader source: Energy.gov [DOE]

    The Imperial Valley Geothermal project consists of 10 generating plants in the Salton Sea Known Geothermal Resource Area in Southern California's Imperial Valley. The combined capacity at Imperial...

  16. Western Area Power Administration

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Area Power Administration Follow-up to Nov. 25, 2008 Transition ... Southwestern Power Administration CONSTRUCTION BUDGET ITEM DESCRIPTION FY 2009* MICROWAVE ...

  17. An aerial radiological survey of the EG G Mound Applied Technologies and surrounding area, Miamisburg, Ohio

    SciTech Connect (OSTI)

    Not Available

    1992-11-01

    An aerial radiological survey was conducted over EG G Mound Applied Technologies, Miamisburg, Ohio, during the period of June 9--24, 1989. The purpose of the 41-square-kilometer (16-square-mile) survey was to document the terrestrial gamma environment of the plant and surrounding area. In addition, ground-based exposure rate measurements and soil samples were obtained to support the aerial data. An exposure rate contour map at 1 meter above ground level was.constructed from the gamma data and overlaid on an aerial photograph and map of the area. Exposure rates measured in the area typically ranged from 9 to 11 microroentgens per hour ([mu]R/h).

  18. Data report: Jean Lake Area, Nevada. National Uranium Resource Evaluation Program

    SciTech Connect (OSTI)

    Cook, J.R.

    1982-05-01

    This report presents the results of detailed sampling of soils, rocks, and dry lake bed material from the area of Jean Dry Lake in southern Nevada. The study area is in the Kingman 1/sup 0/ x 2/sup 0/ quadrangle of the National Topographic Map Series. Samples were collected from 1000 sites. The target density of sampling was 16 sites per square mile in the lake bed and four sites per square mile for soil samples. Neutron activation analyses are presented for uranium and 16 other elements. Scintillometer readings are reported for each site. Analytical data and scintillometer measurements are presented in tables. Statistical summaries and a brief description of the results are given. Data from the sites (on microfiche in pocket) include; (1) elemental analyses (U, Th, Hf, Al, Ce, Dy, Eu, Fe, La, Lu, Mn, Sc, Sm, Na, Ti, and V); and (2) scintillometer readings. To make the data available for public use without further delay, this report is being issued without the normal technical and copy editing.

  19. MiR-138 promotes smooth muscle cells proliferation and migration in db/db mice through down-regulation of SIRT1

    SciTech Connect (OSTI)

    Xu, Juan; Li, Li; Yun, Hui-fang; Han, Ye-shan

    2015-08-07

    Background: Diabetic vascular smooth muscle cells (VSMCs) exhibit significantly increased rates of proliferation and migration, which was the most common pathological change in atherosclerosis. In addition, the study about the role for miRNAs in the regulation of VSMC proliferation is just beginning to emerge and additional miRNAs involved in VSMC proliferation modulation should be identified. Methods: The expression of miR-138 and SIRT1 were examined in SMCs separated from db/db mice and in SMC lines C-12511 exposed to high glucose with qRT-PCR and western blot. The regulation of miR-138 on the expression of SMCs was detected with luciferase report assay. VSMCs proliferation and migration assays were performed to examine the effect of miR-138 inhibitor on VSMCs proliferation and migration. Results: We discovered that higher mRNA level of miR-138 and reduced expression of SIRT1 were observed in SMCs separated from db/db mice and in SMC lines C-12511. Moreover, luciferase report assay showed that the activity of SIRT1 3′-UTR was highly increased by miR-138 inhibitor and reduced by miR-138 mimic. In addition, we examined that the up-regulation of NF-κB induced by high glucose in SMCs was reversed by resveratrol and miR-138 inhibitor. MTT and migration assays showed that miR-138 inhibitor attenuated the proliferation and migration of smooth muscle cells. Conclusion: In this study, we revealed that miR-138 might promote proliferation and migration of SMC in db/db mice through suppressing the expression of SIRT1. - Highlights: • Higher mRNA level of miR-138 was observed in SMCs from db/db mice. • The mRNA and protein level of SIRT1 in SMCs from db/db mice were greatly reduced. • miR-138 could regulate the expression of SIRT1 in SMCs. • SIRT1 overexpression reversed the up-regulation of acetylized p65 and NF-κB induced by high glucose. • MiR-138 inhibitor reversed VSMCs proliferation and migration induced by high glucose.

  20. miR-206 is down-regulated in breast cancer and inhibits cell proliferation through the up-regulation of cyclinD2

    SciTech Connect (OSTI)

    Zhou, Jing; Tian, Ye; Li, Juan; Lu, Binbin; Sun, Ming; Zou, Yanfen; Kong, Rong; Luo, Yanhong; Shi, Yongguo; Wang, Keming; Ji, Guozhong

    2013-04-05

    Highlights: ? miR-206 was downexpressed in tumor samples compared with matched normal samples. ? Enhanced expression of miR-206 could inhibit breast cancer growth in vitro. ? Luciferase confirmed miR-206 functions as an anti-oncogene by targeting cyclinD2. ? A reverse correlation between miR-206 and cyclinD2 in breast cancer was found. -- Abstract: MicroRNAs act as important gene regulators in human genomes, and their aberrant expression is linked to many malignancies. Aberrant expression of miR-206 has been frequently reported in cancer studies; however, the role and mechanism of its function in breast cancer remains unclear. Quantitative real-time PCR was performed to detect the relative expression levels of miR-206 in breast cancer and normal breast tissues. Lower expression of miR-206 in breast cancer tissues was associated with larger tumour size and a more advanced clinical stage. Further in vitro observations showed that the enforced expression of miR-206 in MCF-7 breast cancer cells inhibited cell growth by blocking the G1/S transition and suppressed cell proliferation and colony formation, implying that miR-206 functions as a tumour suppressor in the progression of breast cancer. Interestingly, Luciferase assays first revealed that miR-206 inhibited cyclinD2 expression by targeting two binding sites in the 3?-untranslated region of cyclinD2 mRNA. qRT-PCR and Western blot assays verified that miR-206 reduced cyclinD2 expression at both the mRNA and protein levels. A reverse correlation between miR-206 and cyclinD2 expression was noted in breast cancer tissues. Altogether, our results identify a crucial tumour suppressive role of miR-206 in the progression of breast cancer, at least partly via up-regulation of the expression of cyclinD2, and suggest that miR-206 might be a candidate prognostic predictor or an anticancer therapeutic target for breast cancer patients.

  1. Area Lodging: Knoxville | Y-12 National Security Complex

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    11.9 miles from Y-12 Homewood Suites by Hilton Knoxville, TN 37922 10935 Turkey Drive (I-40I-75 Exit 374) 865.777.0375 fax 865.777.0381 12.1 miles from Y-12 LaQuinta...

  2. Application for a Permit to Operate a Class III Solid Waste Disposal Site at the Nevada Test Site Area 5 Asbestiform Low-Level Solid Waste Disposal Site

    SciTech Connect (OSTI)

    NSTec Environmental Programs

    2010-09-14

    The NTS solid waste disposal sites must be permitted by the state of Nevada Solid Waste Management Authority (SWMA). The SWMA for the NTS is the Nevada Division of Environmental Protection, Bureau of Federal Facilities (NDEP/BFF). The U.S. Department of Energy's National Nuclear Security Administration Nevada Site Office (NNSA/NSO) as land manager (owner), and National Security Technologies (NSTec), as operator, will store, collect, process, and dispose all solid waste by means that do not create a health hazard, a public nuisance, or cause impairment of the environment. NTS disposal sites will not be included in the Nye County Solid Waste Management Plan. The NTS is located approximately 105 kilometers (km) (65 miles [mi]) northwest of Las Vegas, Nevada (Figure 1). The U.S. Department of Energy (DOE) is the federal lands management authority for the NTS, and NSTec is the Management and Operations contractor. Access on and off the NTS is tightly controlled, restricted, and guarded on a 24-hour basis. The NTS has signs posted along its entire perimeter. NSTec is the operator of all solid waste disposal sites on the NTS. The Area 5 RWMS is the location of the permitted facility for the Solid Waste Disposal Site (SWDS). The Area 5 RWMS is located near the eastern edge of the NTS (Figure 2), approximately 26 km (16 mi) north of Mercury, Nevada. The Area 5 RWMS is used for the disposal of low-level waste (LLW) and mixed low-level waste. Many areas surrounding the RWMS have been used in conducting nuclear tests. A Notice of Intent to operate the disposal site as a Class III site was submitted to the state of Nevada on January 28, 1994, and was acknowledged as being received in a letter to the NNSA/NSO on August 30, 1994. Interim approval to operate a Class III SWDS for regulated asbestiform low-level waste (ALLW) was authorized on August 12, 1996 (in letter from Paul Liebendorfer to Runore Wycoff), with operations to be conducted in accordance with the ''Management Plan

  3. CLOSURE REPORT FOR CORRECTIVE ACTION UNIT165: AREA 25 AND 26 DRY WELL AND WASH DOWN AREAS, NEVADA TEST SITE, NEVADA

    SciTech Connect (OSTI)

    BECHTEL NEVADA

    2005-12-01

    This Closure Report (CR) documents the closure activities for Corrective Action Unit (CAU) 165, Area 25 and 26 Dry Well and Washdown Areas, according to the Federal Facility Agreement and Consent Order (FFACO) of 1996. CAU 165 consists of 8 Corrective Action Sites (CASs) located in Areas 25 and 26 of the Nevada Test Site (NTS). The NTS is located approximately 105 kilometers (65 miles) northwest of Las Vegas, nevada. Site closure activities were performed according to the Nevada Division of Environmental Protection (NDEP)-approved Corrective Action Plan (CAP) for CAU 165. CAU 165 consists of the following CASs: (1) CAS 25-07-06, Train Decontamination Area; (2) CAS 25-07-07, Vehicle Washdown; (3) CAS 25-20-01, Lab Drain Dry Well; (4) CAS 25-47-01, Reservoir and French Drain; (5) CAS 25-51-02, Drywell; (6) CAS 25-59-01, Septic System; (7) CAS 26-07-01, Vehicle Washdown Station; and (8) CAS 26-59-01, Septic System. CAU 165, Area 25 and 26 Dry Well and Washdown Areas, consists of eight CASs located in Areas 25 and 26 of the NTS. The approved closure alternatives included No Further Action, Clean Closure, and Closure in Place with Administrative Controls.

  4. Geothermal br Resource br Area Geothermal br Resource br Area...

    Open Energy Info (EERE)

    Aluto Langano Geothermal Area Aluto Langano Geothermal Area East African Rift System Ethiopian Rift Valley Major Normal Fault Basalt MW K Amatitlan Geothermal Area Amatitlan...

  5. Decontamination & decommissioning focus area

    SciTech Connect (OSTI)

    1996-08-01

    In January 1994, the US Department of Energy Office of Environmental Management (DOE EM) formally introduced its new approach to managing DOE`s environmental research and technology development activities. The goal of the new approach is to conduct research and development in critical areas of interest to DOE, utilizing the best talent in the Department and in the national science community. To facilitate this solutions-oriented approach, the Office of Science and Technology (EM-50, formerly the Office of Technology Development) formed five Focus AReas to stimulate the required basic research, development, and demonstration efforts to seek new, innovative cleanup methods. In February 1995, EM-50 selected the DOE Morgantown Energy Technology Center (METC) to lead implementation of one of these Focus Areas: the Decontamination and Decommissioning (D & D) Focus Area.

  6. Hanford 300 Area ROD

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    300 Area ROD Briefing to the Hanford Advisory Board March 6, 2014 Larry Gadbois -- EPA Recap of the 300 Area ROD Primary new concept -- Uranium Sequestration: * Purpose: Accelerate restoration of groundwater uranium contamination. * Protect groundwater from downward leaching from the vadose zone (overlying soil). * Add phosphate to chemically bond with uranium into geologically stable autunite. Does not dissolve. * Dissolve phosphate in water, apply at ground surface, inject into the ground,

  7. Physics Thrust Areas

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Thrust Areas Physics Thrust Areas Physics Division serves the nation through its broad portfolio of fundamental and applied research. Quality basic science research: critical component of maintaining our capabilities in national security research To further understand the physical world, generate new or improved technology in experimental physics, and establish a physics foundation for current and future Los Alamos programs, Physics Division leverages its expertise and experimental capabilities

  8. Nevada Test Site 2007 Data Report: Groundwater Monitoring Program Area 5 Radioactive Waste Management Site

    SciTech Connect (OSTI)

    NSTec Environmental Management

    2008-01-01

    This report is a compilation of the groundwater sampling results from three monitoring wells located near the Area 5 Radioactive Waste Management Site (RWMS) at the Nevada Test Site (NTS), Nye County, Nevada, for calendar year 2007. The NTS is an approximately 3,561 square kilometer (1,375 square mile) restricted-access federal installation located approximately 105 kilometers (65 miles) northwest of Las Vegas, Nevada (Figure 1). Pilot wells UE5PW-1, UE5PW-2, and UE5PW-3 are used to monitor the groundwater at the Area 5 RWMS (Figure 2). In addition to groundwater monitoring results, this report includes information regarding site hydrogeology, well construction, sample collection, and meteorological data measured at the Area 5 RWMS. The disposal of low-level radioactive waste and mixed low-level radioactive waste at the Area 5 RWMS is regulated by U.S. Department of Energy (DOE) Order 435.1, 'Radioactive Waste Management'. The disposal of mixed low-level radioactive waste is also regulated by the state of Nevada under the Resource Conservation and Recovery Act (RCRA) regulation Title 40 Code of Federal Regulations (CFR) Part 265, 'Interim Status Standards for Owners and Operators of Hazardous Waste Treatment, Storage, and Disposal Facilities' (CFR, 1999). The format of this report was requested by the Nevada Division of Environmental Protection (NDEP) in a letter dated August 12, 1997. The appearance and arrangement of this document have been modified slightly since that date to provide additional information and to facilitate the readability of the document. The objective of this report is to satisfy any Area 5 RWMS reporting agreements between DOE and NDEP.

  9. Evapotranspiration Cover for the 92-Acre Area Retired Mixed Waste Pits:Interim CQA Report

    SciTech Connect (OSTI)

    The Delphi Groupe, Inc., and J. A. Cesare and Associates, Inc.

    2011-06-20

    This Interim Construction Quality Assurance (CQA) Report is for the 92-Acre Evapotranspiration Cover, Area 5 Waste Management Division (WMD) Retired Mixed Waste Pits, Nevada National Security Site, Nevada for the period of January 20, 2011 to May 12, 2011. This Interim Construction Quality Assurance (CQA) Report is for the 92-Acre Evapotranspiration Cover, Area 5 Waste Management Division (WMD) Retired Mixed Waste Pits, Nevada National Security Site, Nevada for the period of January 20, 2011 to May 12, 2011. Construction was approved by the Nevada Division of Environmental Protection (NDEP) under the Approval of Corrective Action Decision Document/Corrective Action Plan (CADD/CAP) for Corrective Action Unit (CAU) 111: Area 5 WMD Retired Mixed Waste Pits, Nevada National Security Site, Nevada, on January 6, 2011, pursuant to Subpart XII.8a of the Federal Facility Agreement and Consent Order. The project is located in Area 5 of the Radioactive Waste Management Complex (RWMC) at the Nevada National Security Site (NNSS), formerly known as the Nevada Test Site, located in southern Nevada, approximately 65 miles northwest of Las Vegas, Nevada, in Nye County. The project site, in Area 5, is located in a topographically closed basin approximately 14 additional miles north of Mercury Nevada, in the north-central part of Frenchman Flat. The Area 5 RWMS uses engineered shallow-land burial cells to dispose of packaged waste. The 92-Acre Area encompasses the southern portion of the Area 5 RWMS, which has been designated for the first final closure operations. This area contains 13 Greater Confinement Disposal (GCD) boreholes, 16 narrow trenches, and 9 broader pits. With the exception of two active pits (P03 and P06), all trenches and pits in the 92-Acre Area had operational covers approximately 2.4 meters thick, at a minimum, in most areas when this project began. The units within the 92-Acre Area are grouped into the following six informal categories based on physical location

  10. Validation of the MCNPX-PoliMi Code to Design a Fast-Neutron Multiplicity Counter

    SciTech Connect (OSTI)

    J. L. Dolan; A. C. Kaplan; M. Flaska; S. A. Pozzi; D. L. Chichester

    2012-07-01

    Many safeguards measurement systems used at nuclear facilities, both domestically and internationally, rely on He-3 detectors and well established mathematical equations to interpret coincidence and multiplicity-type measurements for verifying quantities of special nuclear material. Due to resource shortages alternatives to these existing He-3 based systems are being sought. Work is also underway to broaden the capabilities of these types of measurement systems in order to improve current multiplicity analysis techniques. As a part of a Material Protection, Accounting, and Control Technology (MPACT) project within the U.S. Department of Energy's Fuel Cycle Technology Program we are designing a fast-neutron multiplicity counter with organic liquid scintillators to quantify important quantities such as plutonium mass. We are also examining the potential benefits of using fast-neutron detectors for multiplicity analysis of advanced fuels in comparison with He-3 detectors and testing the performance of such designs. The designs are being developed and optimized using the MCNPX-PoliMi transport code to study detector response. In the full paper, we will discuss validation measurements used to justify the use of the MCNPX-PoliMi code paired with the MPPost multiplicity routine to design a fast neutron multiplicity counter with liquid scintillators. This multiplicity counter will be designed with the end goal of safeguarding advanced nuclear fuels. With improved timing qualities associated with liquid scintillation detectors, we can design a system that is less limited by nuclear materials of high activities. Initial testing of the designed system with nuclear fuels will take place at Idaho National Laboratory in a later stage of this collaboration.

  11. Use of Facility Contractor Employees for Services to DOE in the Washington, D.C., Area

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-04-15

    To clarify and modify policies and procedures for management of Department of Energy (DOE) facility contractor employees located in the Washington, D.C., area. A facility contractor employee is any employee of either a contractor responsible for managing a Department-owned facility, such as a National Laboratory, or a subcontractor of such a contractor. Facility contractor means any contractor performing under a Management and Operating (M&O), Management and Integration (M&I), or Environmental Restoration Management Contractor (ERMC) contract awarded by a DOE contracting officer. Canceled by DOE O 350.2.

  12. Closure Report for Corrective Action Unit 396: Area 20 Spill Sites, Nevada Test Site, Nevada

    SciTech Connect (OSTI)

    U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; Bechtel Nevada

    2004-06-01

    Corrective Action Unit (CAU) 396, Area 20 Spill Sites, is located on the Nevada Test Site approximately 105 kilometers (65 miles) northwest of Las Vegas, Nevada. CAU 396 is listed in Appendix II of the Federal Facility Agreement and Consent Order of 1996 and consists of the following four Corrective Action Sites (CASs) located in Area 20 of the Nevada Test Site: CAS 20-25-01, Oil Spills (2); CAS 20-25-02, Oil Spills; CAS 20-25-03, Oil Spill; CAS 20-99-08, Spill. Closure activities for CAU 396 were conducted in accordance with the Federal Facility Agreement and Consent Order and the Nevada Division of Environmental Protection-approved Streamlined Approach for Environmental Restoration Plan for CAU 396.

  13. Corrective action investigation plan for CAU No. 424: Area 3 Landfill Complex, Tonopah Test Range, Nevada

    SciTech Connect (OSTI)

    1997-04-01

    This Correction Action Investigation Plan contains the environmental sample collection objectives and the criteria for conducting site investigation activities at the Area 3 Landfill Complex, CAU No. 424, which is located at the Tonopah Test Range (TTR). The TTR, included in the Nellis Air Force Range, is approximately 255 kilometers (140 miles) northwest of Las Vegas, nevada. The CAU 424 is comprised of eight individual landfill sites that are located around and within the perimeter of the Area 3 Compound. Due to the unregulated disposal activities commonly associated with early landfill operations, an investigation will be conducted at each CAS to complete the following tasks: identify the presence and nature of possible contaminant migration from the landfills; determine the vertical and lateral extent of possible contaminant migration; ascertain the potential impact to human health and the environment; and provide sufficient information and data to develop and evaluate appropriate corrective action strategies for each CAS.

  14. Geology and hydrocarbon potential of the Sepik-Ramu area, Ramu basin, Papua New Guinea

    SciTech Connect (OSTI)

    Donaldson, J.C.; Wilson, J.T. )

    1990-06-01

    Improvements in seismic processing have made new interpretations of the structural and depositional history of the northwestern portion of the Ramu basin possible. Support for a wrench tectonic model for this area is observed in the reprocessed seismic data. Strike-slip movement along major fault zones has allowed compressional forces to be translated laterally and resulted in only minor deformation occurring in the Sepik-Ramu area. The major tectonic event is thought to have occurred during late Miocene-early Pliocene, and not during the middle Miocene, as earlier hypothesized. Consequently, Miocene deposition is postulated to have occurred uninterrupted by periods of erosion. A thick Miocene section is preserved in this region and is postulated to contain slope, reef, and shelf carbonates of early to middle Miocene age. This interpretation has led to the identification of a reef trend over 7 mi wide and at least 42 mi long containing numerous pinnacle reefs. The pinnacle reefs are analogous to those found in the Salawati basin of Irian Jaya, Indonesia. The reefs are overlain by deep-water shales, a combination that provides potential reservoirs and seals necessary for the entrapment of hydrocarbons. The presence of oil and gas seeps document the existence of a source. These three factors justify hydrocarbon exploration in this area. The numerous potential drilling targets may lead to the discovery of significant quantities of hydrocarbons.

  15. Closure Report for Corrective Action Unit 425: Area 9 Main Lake Construction Debris Disposal Area, Tonopah Test Range, Nevada

    SciTech Connect (OSTI)

    K. B. Campbell

    2003-03-01

    Corrective Action Unit (CAU) 425 is located on the Tonopah Test Range, approximately 386 kilometers (240 miles) northwest of Las Vegas, Nevada. CAU 425 is listed in the Federal Facility Agreement and Consent Order (FFACO, 1996) and is comprised of one Corrective Action Site (CAS). CAS 09-08-001-TA09 consisted of a large pile of concrete rubble from the original Hard Target and construction debris associated with the Tornado Rocket Sled Tests. CAU 425 was closed in accordance with the FFACO and the Nevada Division of Environmental Protection-approved Streamlined Approach for Environmental Restoration Plan for CAU 425: Area 9 Main Lake Construction Debris Disposal Area, Tonopah Test Range, Nevada (U.S. Department of Energy, Nevada Operations Office, 2002). CAU 425 was closed by implementing the following corrective actions: The approved corrective action for this unit was clean closure. Closure activities included: (1) Removal of all the debris from the site. (2) Weighing each load of debris leaving the job site. (3) Transporting the debris to the U.S. Air Force Construction Landfill for disposal. (4) Placing the radioactive material in a U.S. Department of Transportation approved container for proper transport and disposal. (5) Transporting the radioactive material to the Nevada Test Site for disposal. (6) Regrading the job site to its approximate original contours/elevation.

  16. Report of biological investigations at the Los Medanos Waste Isolation Pilot Plant (WIPP) area of New Mexico during FY 1978

    SciTech Connect (OSTI)

    Best, T.L.; Neuhauser, S.

    1980-03-01

    The US Department of Energy is considering the construction of a Waste Isolation Pilot Plant (WIPP) in Eddy County, NM. This location is approximately 40 km east of Carlsbad, NM. Biological studies during FY 1978 were concentrated within a 5-mi radius of drill hole ERDA 9. Additional study areas have been established at other sites in the vicinity, e.g., the Gnome site, the salt lakes and several stations along the Pecos River southward from Carlsbad, NM, to the dam at Red Bluff Reservoir in Texas. The precise locations of all study areas are presented and their biology discussed.

  17. OLED area illumination source

    DOE Patents [OSTI]

    Foust, Donald Franklin; Duggal, Anil Raj; Shiang, Joseph John; Nealon, William Francis; Bortscheller, Jacob Charles

    2008-03-25

    The present invention relates to an area illumination light source comprising a plurality of individual OLED panels. The individual OLED panels are configured in a physically modular fashion. Each OLED panel comprising a plurality of OLED devices. Each OLED panel comprises a first electrode and a second electrode such that the power being supplied to each individual OLED panel may be varied independently. A power supply unit capable of delivering varying levels of voltage simultaneously to the first and second electrodes of each of the individual OLED panels is also provided. The area illumination light source also comprises a mount within which the OLED panels are arrayed.

  18. Operational Area Monitoring Plan

    Office of Legacy Management (LM)

    ' SECTION 11.7B Operational Area Monitoring Plan for the Long -Term H yd rol og ical M o n i to ri ng - Program Off The Nevada Test Site S . C. Black Reynolds Electrical & Engineering, Co. and W. G. Phillips, G. G. Martin, D. J. Chaloud, C. A. Fontana, and 0. G. Easterly Environmental Monitoring Systems Laboratory U. S. Environmental Protection Agency October 23, 1991 FOREWORD This is one of a series of Operational Area Monitoring Plans that comprise the overall Environmental Monitoring Plan

  19. Site Monitoring Area Maps

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The spatial location and boundaries for each Site shown on the Site Monitoring Area maps ... P-SMA-2 DP-SMA-0.4 LA-SMA-2.3 LA-SMA-5.51 LA-SMA-6.38 P-SMA-2.15 DP-SMA-0.6 ...

  20. Plutonium focus area

    SciTech Connect (OSTI)

    1996-08-01

    To ensure research and development programs focus on the most pressing environmental restoration and waste management problems at the U.S. Department of Energy (DOE), the Assistant Secretary for the Office of Environmental Management (EM) established a working group in August 1993 to implement a new approach to research and technology development. As part of this new approach, EM developed a management structure and principles that led to the creation of specific Focus Areas. These organizations were designed to focus the scientific and technical talent throughout DOE and the national scientific community on the major environmental restoration and waste management problems facing DOE. The Focus Area approach provides the framework for intersite cooperation and leveraging of resources on common problems. After the original establishment of five major Focus Areas within the Office of Technology Development (EM-50, now called the Office of Science and Technology), the Nuclear Materials Stabilization Task Group (EM-66) followed the structure already in place in EM-50 and chartered the Plutonium Focus Area (PFA). The following information outlines the scope and mission of the EM, EM-60, and EM-66 organizations as related to the PFA organizational structure.

  1. Subsurface contaminants focus area

    SciTech Connect (OSTI)

    1996-08-01

    The US Department of Enregy (DOE) Subsurface Contaminants Focus Area is developing technologies to address environmental problems associated with hazardous and radioactive contaminants in soil and groundwater that exist throughout the DOE complex, including radionuclides, heavy metals; and dense non-aqueous phase liquids (DNAPLs). More than 5,700 known DOE groundwater plumes have contaminated over 600 billion gallons of water and 200 million cubic meters of soil. Migration of these plumes threatens local and regional water sources, and in some cases has already adversely impacted off-site rsources. In addition, the Subsurface Contaminants Focus Area is responsible for supplying technologies for the remediation of numerous landfills at DOE facilities. These landfills are estimated to contain over 3 million cubic meters of radioactive and hazardous buried Technology developed within this specialty area will provide efective methods to contain contaminant plumes and new or alternative technologies for development of in situ technologies to minimize waste disposal costs and potential worker exposure by treating plumes in place. While addressing contaminant plumes emanating from DOE landfills, the Subsurface Contaminants Focus Area is also working to develop new or alternative technologies for the in situ stabilization, and nonintrusive characterization of these disposal sites.

  2. Property:AreaGeology | Open Energy Information

    Open Energy Info (EERE)

    Geothermal Area B Beowawe Hot Springs Geothermal Area Blue Mountain Geothermal Area Brady Hot Springs Geothermal Area C Chena Geothermal Area Coso Geothermal Area D Desert Peak...

  3. Hydrogeologic Setting of A/M Area: Framework for Groundwater Transport. Book 1

    SciTech Connect (OSTI)

    Van Pelt, R.; Lewis, S.E.; Aadland, R.K.

    1994-03-11

    This document includes a brief summary of the regional geology within a 200--mile radius of the A/M Area, a summary of stratigraphy and hydrostratigraphic nomenclature as it applies to the A/M Area, and a summary of stratigraphy and hydrostratigraphy specific to the A/M Area. Five different stratigraphic cross sections show site-specific geology of the Tertiary section of the Upper Atlantic Coastal Plain geologic province within the A/M Area. The Cretaceous section lacks detail because the deepest wells penetrate only the uppermost part of the Upper Cretaceous sediments. Most of the wells are confined to the Tertiary section. The A/M Area is located in the northwestern corner of the Savannah River Site (SRS). The area serves as a main administrative hub for the site. Between 1958 and 1985, approximately 2,000,000 pounds of volatile organic solvents (metal degreasers, primarily trichloroethylene and tetrachloroethylene) were routed to the M Area Settling Basin. Between 1954 and 1958, effluent also was discharged to Tim`s Branch via the A014 Outfall. In the main M Area Solvent Handling/Storage Area, a significant amount of leakage occurred from drums stored during this time period. Extensive quantities of solvents were transported, via the Process Sewer Line, to the M Area Settling Basin, and leaks occurred along this line as well. A smaller source area has been identified and is centered around the Savannah River Laboratory (SRL) (now called the Savannah River Technology Center [SRTC]) Complex. All of these source areas are represented by solvent contamination in the groundwater system. (Abstract Truncated)

  4. Baseline risk assessment for groundwater operable units at the Chemical Plant Area and the Ordnance Works Area, Weldon Spring, Missouri

    SciTech Connect (OSTI)

    1999-07-14

    The U.S. Department of Energy (DOE) and the U.S. Department of the Army (DA) are evaluating conditions in groundwater and springs at the DOE chemical plant area and the DA ordnance works area near Weldon Spring, Missouri. The two areas are located in St. Charles County, about 48 km (30 mi) west of St. Louis. The 88-ha (217-acre) chemical plant area is chemically and radioactively contaminated as a result of uranium-processing activities conducted by the U.S. Atomic Energy Commission in the 1950s and 1960s and explosives-production activities conducted by the U.S. Army (Army) in the 1940s. The 6,974-ha (17,232-acre) ordnance works area is primarily chemically contaminated as a result of trinitrotoluene (TNT) and dinitrotoluene (DNT) manufacturing activities during World War II. This baseline risk assessment (BRA) is being conducted as part of the remedial investigation/feasibility study (RUFS) required under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) of 1980, as amended. The purpose of the BRA is to evaluate potential human health and ecological impacts from contamination associated with the groundwater operable units (GWOUs) of the chemical plant area and ordnance works area. An RI/FS work plan issued jointly in 1995 by the DOE and DA (DOE 1995) analyzed existing conditions at the GWOUs. The work plan included a conceptual hydrogeological model based on data available when the report was prepared; this model indicated that the aquifer of concern is common to both areas. Hence, to optimize further data collection and interpretation efforts, the DOE and DA have decided to conduct a joint RI/BRA. Characterization data obtained from the chemical plant area wells indicate that uranium is present at levels slightly higher than background, with a few concentrations exceeding the proposed U.S. Environmental Protection Agency (EPA) maximum contaminant level (MCL) of 20 {micro}g/L (EPA 1996c). Concentrations of other radionuclides (e

  5. Figure 1. Project Area, Focused Study Area, Potential Access...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Page 4 of 8 Figure 1. Project Area, Focused Study Area, Potential Access Agreement Land, and Land Not Suitable for Conveyance

  6. Figure 1. Project Area, Focused Study Area, Potential Access...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Page 4 of 8 Figure 1. Project Area, Focused Study Area, Potential Access Agreement Land, and Land Not Suitable for Conveyance...

  7. Ginsenoside-Rg{sub 1} induces angiogenesis by the inverse regulation of MET tyrosine kinase receptor expression through miR-23a

    SciTech Connect (OSTI)

    Kwok, Hoi-Hin; Chan, Lai-Sheung; Poon, Po-Ying; Yue, Patrick Ying-Kit; Wong, Ricky Ngok-Shun

    2015-09-15

    Therapeutic angiogenesis has been implicated in ischemic diseases and wound healing. Ginsenoside-Rg{sub 1} (Rg{sub 1}), one of the most abundant active components of ginseng, has been demonstrated as an angiogenesis-stimulating compound in different models. There is increasing evidence implicating microRNAs (miRNAs), a group of non-coding RNAs, as important regulators of angiogenesis, but the role of microRNAs in Rg{sub 1}-induced angiogenesis has not been fully explored. In this report, we found that stimulating endothelial cells with Rg{sub 1} could reduce miR-23a expression. In silico experiments predicted hepatocyte growth factor receptor (MET), a well-established mediator of angiogenesis, as the target of miR-23a. Transfection of the miR-23a precursor or inhibitor oligonucleotides validated the inverse relationship of miR-23a and MET expression. Luciferase reporter assays further confirmed the interaction between miR-23a and the MET mRNA 3′-UTR. Intriguingly, ginsenoside-Rg{sub 1} was found to increase MET protein expression in a time-dependent manner. We further demonstrated that ginsenoside-Rg{sub 1}-induced angiogenic activities were indeed mediated through the down-regulation of miR-23a and subsequent up-regulation of MET protein expression, as confirmed by gain- and loss-of-function angiogenic experiments. In summary, our results demonstrated that ginsenoside-Rg{sub 1} could induce angiogenesis by the inverse regulation of MET tyrosine kinase receptor expression through miR-23a. This study has broadened our understanding of the non-genomic effects of ginsenoside-Rg{sub 1,} and provided molecular evidence that warrant further development of natural compound as novel angiogenesis-promoting therapy. - Highlights: • Therapeutic angiogenesis has been implicated in ischemic diseases and wound healing. • Ginsenoside-Rg{sub 1} (Rg{sub 1}) has been demonstrated as an angiogenesis-stimulating compound. • We found that Rg{sub 1} induces angiogenesis by

  8. Closure Report for Corrective Action Unit 254: Area 25, R-MAD Decontamination Facility, Nevada Test Site, Nevada

    SciTech Connect (OSTI)

    G. N. Doyle

    2002-02-01

    Corrective Action Unit (CAU) 254 is located in Area 25 of the Nevada Test Site (NTS), approximately 100 kilometers (km) (62 miles) northwest of Las Vegas, Nevada. The site is located within the Reactor Maintenance, Assembly and Disassembly (R-MAD) compound and consists of Building 3126, two outdoor decontamination pads, and surrounding areas within an existing fenced area measuring approximately 50 x 37 meters (160 x 120 feet). The site was used from the early 1960s to the early 1970s as part of the Nuclear Rocket Development Station program to decontaminate test-car hardware and tooling. The site was reactivated in the early 1980s to decontaminate a radiologically contaminated military tank. This Closure Report (CR) describes the closure activities performed to allow un-restricted release of the R-MAD Decontamination Facility.

  9. Bay Area | Open Energy Information

    Open Energy Info (EERE)

    Page Edit History Bay Area Jump to: navigation, search Contents 1 Clean Energy Clusters in the Bay Area 1.1 Products and Services in the Bay Area 1.2 Research and Development...

  10. Rockies Area | Open Energy Information

    Open Energy Info (EERE)

    Rockies Area Jump to: navigation, search Contents 1 Clean Energy Clusters in the Rockies Area 1.1 Products and Services in the Rockies Area 1.2 Research and Development...

  11. Texas Area | Open Energy Information

    Open Energy Info (EERE)

    Area Jump to: navigation, search Contents 1 Clean Energy Clusters in the Texas Area 1.1 Products and Services in the Texas Area 1.2 Research and Development Institutions in the...

  12. Analysis of the hydraulic data from the MI fracture zone at the Grimsel Rock Laboratory, Switzerland

    SciTech Connect (OSTI)

    Davey, A.; Karasaki, K.; Long, J.C.S.; Landsfeld, M.; Mensch, A.; Martel, S.J.

    1989-10-01

    One of the major problems in analyzing flow and transport in fractured rock is that the flow may be largely confined to a poorly connected network of fractures. In order to overcome some of this problem, Lawrence Berkeley Laboratory (LBL) has been developing a new type of fracture hydrology model called an equivalent discontinuum model. In this model the authors represent the discontinuous nature of the problem through flow on a partially filled lattice. A key component in constructing an equivalent discontinuum model from this lattice is removing some of the conductive elements such that the system is partially connected in the same manner as the fracture network. This is done through a statistical inverse technique called simulated annealing. The fracture network model is annealed by continually modifying a base model, or template such that the modified systems behave more and more like the observed system. In order to see how the simulated annealing algorithm works, the authors have developed a series of synthetic real cases. In these cases, the real system is completely known so that the results of annealing to steady state data can be evaluated absolutely. The effect of the starting configuration has been studied by varying the percent of conducting elements in the initial configuration. Results have shown that the final configurations converge to about the same percentage of conducting elements. An example using Nagra field data from the Migration Experiment (MI) at Grimsel Rock Laboratory in Switzerland is also analyzed. 24 refs., 33 figs., 3 tabs.

  13. Large area bulk superconductors

    DOE Patents [OSTI]

    Miller, Dean J.; Field, Michael B.

    2002-01-01

    A bulk superconductor having a thickness of not less than about 100 microns is carried by a polycrystalline textured substrate having misorientation angles at the surface thereof not greater than about 15.degree.; the bulk superconductor may have a thickness of not less than about 100 microns and a surface area of not less than about 50 cm.sup.2. The textured substrate may have a thickness not less than about 10 microns and misorientation angles at the surface thereof not greater than about 15.degree.. Also disclosed is a process of manufacturing the bulk superconductor and the polycrystalline biaxially textured substrate material.

  14. Aeromagnetic Survey At Clear Lake Area (Skokan, 1993) | Open...

    Open Energy Info (EERE)

    not indicated DOE-funding Unknown Notes USGS aeromagnetic data (Rapolla and Keller, 1984) were acquired at an elevation of 4500 feet and flown with one-mile spacings. These...

  15. Climatological summary for the Hanford area

    SciTech Connect (OSTI)

    Stone, W.A.; Thorp, J.M.; Gifford, O.P.; Hoitink, D.J.

    1983-06-01

    This report is a summarization of meteorological observations from the Hanford Meteorology Station (HMS), located near Richland, Washington. The information in this document is based on records kept at the HMS from 1946 to 1980, supplemented with precipitation and temperature data taken by US Weather Bureau cooperative observers at a site about 10 miles east-northeast of HMS during the period 1912 to 1943. 8 references, 41 figures, 70 tables.

  16. T-1 Training Area

    SciTech Connect (OSTI)

    2014-11-07

    Another valuable homeland security asset at the NNSS is the T-1 training area, which covers more than 10 acres and includes more than 20 separate training venues. Local, County, and State first responders who train here encounter a variety of realistic disaster scenarios. A crashed 737 airliner lying in pieces across the desert, a helicopter and other small aircraft, trucks, buses, and derailed train cars are all part of the mock incident scene. After formal classroom education, first responders are trained to take immediate decisive action to prevent or mitigate the use of radiological or nuclear devices by terrorists. The Counterterrorism Operations Support Center for Radiological Nuclear Training conducts the courses and exercises providing first responders from across the nation with the tools they need to protect their communities. All of these elements provide a training experience that cannot be duplicated anywhere else in the country.

  17. T-1 Training Area

    ScienceCinema (OSTI)

    None

    2015-01-09

    Another valuable homeland security asset at the NNSS is the T-1 training area, which covers more than 10 acres and includes more than 20 separate training venues. Local, County, and State first responders who train here encounter a variety of realistic disaster scenarios. A crashed 737 airliner lying in pieces across the desert, a helicopter and other small aircraft, trucks, buses, and derailed train cars are all part of the mock incident scene. After formal classroom education, first responders are trained to take immediate decisive action to prevent or mitigate the use of radiological or nuclear devices by terrorists. The Counterterrorism Operations Support Center for Radiological Nuclear Training conducts the courses and exercises providing first responders from across the nation with the tools they need to protect their communities. All of these elements provide a training experience that cannot be duplicated anywhere else in the country.

  18. Microsoft PowerPoint - Central_Plateau_Outer_Zone.ppt [Compatibility Mode]

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Outer Zone Th t f th C t l Pl t i b t 65 il The outer zone of the Central Plateau is about 65 square miles. Recovery Act funding will be used in this area to support shrinking the active footprint of cleanup to as little as 10 square miles in the center of the site. Work will consist mainly of demolishing facilities and remediating waste sites. Central Plateau, Outer Zone (~65 sq. mi.) * 200 North Area * Demolish spent fuel C o C o * Demolish spent fuel transfer storage facilities (212 N/P/R) *

  19. Characterization ReportOperational Closure Covers for the Area 5 Radioactive Waste Management Site at the Nevada Test Site

    SciTech Connect (OSTI)

    Bechtel Nevada Geotechnical Sciences

    2005-06-01

    Bechtel Nevada (BN) manages two low-level Radioactive Waste Management Sites (RWMSs) at the Nevada Test Site (NTS) for the U.S. Department of Energy (DOE) National Nuclear Security Administration Nevada Site Office (NNSA/NSO). The Area 3 RWMS is located in south-central Yucca Flat and the Area 5 RWMS is located about 15 miles south, in north-central Frenchman Flat. Though located in two separate topographically closed basins, they are similar in climate and hydrogeologic setting. The Area 5 RWMS uses engineered shallow-land burial cells to dispose of packaged waste, while the Area 3 RWMS uses subsidence craters formed from underground testing of nuclear weapons for the disposal of packaged and unpackaged bulk waste. Over the next several decades, most waste disposal units at both the Area 3 and Area 5 RWMSs are anticipated to be closed. Closure of the Area 3 and Area 5 RWMSs will proceed through three phases: operational closure, final closure, and institutional control. Many waste disposal units at the Area 5RWMS are operationally closed and final closure has been placed on one unit at the Area 3 RWMS (U-3ax/bl). Because of the similarities between the two sites (e.g., type of wastes, environmental factors, operational closure cover designs, etc.), many characterization studies and data collected at the Area 3 RWMS are relevant and applicable to the Area 5 RWMS. For this reason, data and closure strategies from the Area 3 RWMS are referred to as applicable. This document is an interim Characterization Report – Operational Closure Covers, for the Area 5 RWMS. The report briefly describes the Area 5 RWMS and the physical environment where it is located, identifies the regulatory requirements, reviews the approach and schedule for closing, summarizes the monitoring programs, summarizes characterization studies and results, and then presents conclusions and recommendations.

  20. AREA RADIATION MONITOR

    DOE Patents [OSTI]

    Manning, F.W.; Groothuis, S.E.; Lykins, J.H.; Papke, D.M.

    1962-06-12

    S>An improved area radiation dose monitor is designed which is adapted to compensate continuously for background radiation below a threshold dose rate and to give warning when the dose integral of the dose rate of an above-threshold radiation excursion exceeds a selected value. This is accomplished by providing means for continuously charging an ionization chamber. The chamber provides a first current proportional to the incident radiation dose rate. Means are provided for generating a second current including means for nulling out the first current with the second current at all values of the first current corresponding to dose rates below a selected threshold dose rate value. The second current has a maximum value corresponding to that of the first current at the threshold dose rate. The excess of the first current over the second current, which occurs above the threshold, is integrated and an alarm is given at a selected integrated value of the excess corresponding to a selected radiation dose. (AEC)

  1. SSL Demonstration: Area Lighting Yuma Sector Border Patrol Area...

    Energy Savers [EERE]

    DEMONSTRATION: Area Lighting Yuma Sector Border Patrol Area, AZ A unique GATEWAY evaluation on a stretch of border between the U.S. and Mexico looks at how high-flux LED lighting ...

  2. Streamlined approach for environmental restoration closure report for Corrective Action Unit 120: Areas 5 and 6 aboveground storage tanks, Nevada Test Site, Nevada

    SciTech Connect (OSTI)

    1999-06-01

    This Closure Report provides documentation for the closure of Corrective Action Unit (CAU) 120 of the Federal Facilities Agreement and Consent Order (FFACO). CAU 120 consists of two Corrective Action Sites (CASs) located in Areas 5 and 6 of the Nevada Test Site (NTS), which are approximately 130 kilometers (80 miles) northwest of Las Vegas, Nevada. CAS 05-01-01 is located in Area 5 and consists of three 45,800-liter (12,100-gallon) aboveground storage tanks (ASTs), piping, and debris associated with Well RNM-1. CAS 06-01-01 consists of two ASTs and two tanker trailers (all portable) that were originally located at the Area 6 Cp-50 Hot Park and which had been moved to the Area 6 Waste Handling Facility. All of the items in CAU 120 have been used to contain or convey radiologically contaminated fluid that was generated during post-nuclear event activities at the NTS.

  3. 1st Mile | Open Energy Information

    Open Energy Info (EERE)

    research and screening for venture capitalists. Website: www.1stmile.dk Coordinates: 56.866669, 8.31667 Show Map Loading map... "minzoom":false,"mappingservice":"googlemap...

  4. Application of an Area-of-Review (AOR) Concept to the East Texas Field and Other Selected Texas Oilfields

    SciTech Connect (OSTI)

    Warner, Don L.; Koederitz, Leonard F.; Laudon, Robert C.

    2001-04-19

    The Underground Injection Control Regulations promulgated in 1980, under the Safe Drinking Water Act of 1974, require Area-of-Review (AOR) studies be conducted as part of the permitting process for newly drilled or converted Class II injection wells. Existing Class II injection wells operating at the time regulations became effective were excluded from the AOR requirement. The AOR is the area surrounding an injection well or wells defined by either the radial distance within which pressure in the injection zone may cause migration of the injection and/or formation fluid into an underground source of drinking water (USDW) or defined by a fixed radius of not less than one-fourth mile. In the method where injection pressure is used to define the AOR radial distance, the AOR is also known as the ''zone of endangering influence.''

  5. Environmental characterization report for the Gulf Interior Region, Texas study area. [Oakwood, Palestine and Keechi salt domes

    SciTech Connect (OSTI)

    Not Available

    1982-10-01

    This report is published as a product of the National Waste Terminal Storage (NWTS) Program. The objective of this program is the development of terminal waste storage facilities in deep, stable geologic formations for high-level nuclear waste, including spent fuel elements from commercial power reactors and transuranic nuclear waste for which the federal government is responsible. The report is part of the area study phase and contains environmental information for the Texas Study Area of the Gulf Interior Region acquired from federal, state, and regional agencies. The data in this report meet the requirements of predetermined survey plans and will be used in determining locations of approximately 80 square kilometers (30 square miles) that will be further characterized. Information on surface water, atmosphere, background radiation, natural ecosystems, agricultural systems, demography, socioeconomics, land use, and transportation is presented. The environmental characterization will ensure that data on environmental values required by the National Environmental Policy Act (NEPA) of 1969 are available.

  6. Closure Report for Corrective Action Unit 481: Area 12 T-Tunnel Conditional Release Storage Yard, Nevada Test Site, Nevada

    SciTech Connect (OSTI)

    NSTec Environmental Restoration

    2008-11-01

    Corrective Action Unit (CAU) 481 is identified in the Federal Facility Agreement and Consent Order (FFACO) as Area 12 T-Tunnel Conditional Release Storage Yard. CAU 481 is located in Area 12 of the Nevada Test Site, which is approximately 65 miles northwest of Las Vegas, Nevada. This CAU consists of one Corrective Action Site (CAS), CAS 12-42-05, Housekeeping Waste. CAU 481 closure activities were conducted by the Defense Threat Reduction Agency from August 2007 through July 2008 according to the FFACO and Revision 3 of the Sectored Clean-up Work Plan for Housekeeping Category Waste Sites. Closure activities included removal and disposal of construction debris and low-level waste. Drained fluids, steel, and lead was recycled as appropriate. Waste generated during closure activities was appropriately managed and disposed.

  7. F Reactor Area Cleanup Complete

    Broader source: Energy.gov [DOE]

    RICHLAND, Wash. – U.S. Department of Energy (DOE) contractors have cleaned up the F Reactor Area, the first reactor area at the Hanford Site in southeastern Washington state to be fully remediated.

  8. Focus Areas | Critical Materials Institute

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Focus Areas FA 1: Diversifying Supply FA 2: Developing Substitutes FA 3: Improving Reuse and Recycling FA 4: Crosscutting Research

  9. Mitsubishi iMiEV: An Electric Mini-Car in NREL's Advanced Technology Vehicle Fleet (Fact Sheet)

    SciTech Connect (OSTI)

    Not Available

    2011-10-01

    This fact sheet highlights the Mitsubishi iMiEV, an electric mini-car in the advanced technology vehicle fleet at the National Renewable Energy Laboratory (NREL). In support of the U.S. Department of Energy's fast-charging research efforts, NREL engineers are conducting charge and discharge performance testing on the vehicle. NREL's advanced technology vehicle fleet features promising technologies to increase efficiency and reduce emissions without sacrificing safety or comfort. The fleet serves as a technology showcase, helping visitors learn about innovative vehicles that are available today or are in development. Vehicles in the fleet are representative of current, advanced, prototype, and emerging technologies.

  10. EIS-0402: Remediation of Area IV of the Santa Susana Field Laboratory...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Susana Field Laboratory (SSFL) in eastern Ventura County, California, approximately 29 miles north of downtown Los Angeles. (DOE's operations bordered the Northern Buffer Zone. ...

  11. Gulf Coast Salt Domes geologic Area Characterization Report, East Texas Study Area. Volume II. Technical report. [Contains glossary of geological terms; Oakwood, Keechi, and Palestine domes

    SciTech Connect (OSTI)

    Not Available

    1982-07-01

    The East Texas Area Characterization Report (ACR) is a compilation of data gathered during the Area Characterization phase of the Department of Energy's National Waste Terminal Storage program in salt. The characterization of Gulf Coast Salt Domes as a potential site for storage of nuclear waste is an ongoing process. This report summarizes investigations covering an area of approximately 2590 km/sup 2/ (1000 mi/sup 2/). Data on Oakwood, Keechi, and Palestine Domes are given. Subsequent phases of the program will focus on smaller land areas and fewer specific salt domes, with progressively more detailed investigations, possibly culminating with a license application to the Nuclear Regulatory Commission. The data in this report are a result of drilling and sampling, geophysical and geologic field work, and intensive literature review. The ACR contains text discussing data usage, interpretations, results and conclusions based on available geologic and hydrologic data, and figures including diagrams showing data point locations, geologic and hydrologic maps, geologic cross sections, and other geologic and hydrologic information. An appendix contains raw data gathered during this phase of the project and used in the preparation of these reports.

  12. Geothermal resource area 9: Nye County. Area development plan

    SciTech Connect (OSTI)

    Pugsley, M.

    1981-01-01

    Geothermal Resource area 9 encompasses all of Nye County, Nevada. Within this area there are many different known geothermal sites ranging in temperature from 70/sup 0/ to over 265/sup 0/ F. Fifteen of the more major sites have been selected for evaluation in this Area Development Plan. Various potential uses of the energy found at each of the resource sites discussed in this Area Development Plan were determined after evaluating the area's physical characteristics, land ownership and land use patterns, existing population and projected growth rates, and transportation facilities, and comparing those with the site specific resource characteristics. The uses considered were divided into five main categories: electrical generation, space heating, recreation, industrial process heat, and agriculture. Within two of these categories certain subdivisions were considered separately. The findings about each of the 15 geothermal sites considered in this Area Development Plan are summarized.

  13. SSL Demonstration: Area Lighting, Yuma Sector Border Patrol Area, AZ

    SciTech Connect (OSTI)

    2015-05-28

    Along the Yuma Sector Border Patrol Area in Yuma, Arizona, the GATEWAY program conducted a trial demonstration in which the incumbent quartz metal halide area lighting was replaced with LED at three pole locations at the Yuma Sector Border Patrol Area in Yuma, Arizona. The retrofit was documented to better understand LED technology performance in high-temperature environments. This document is a summary brief of the Phase 1.0 and 1.1 reports previously published on this demonstration.

  14. Desert Peak Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Desert Peak Geothermal Area (Redirected from Desert Peak Area) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Desert Peak Geothermal Area Contents 1 Area Overview 2...

  15. PPPL Area Map | Princeton Plasma Physics Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    PPPL Area Map View Larger Map

  16. Property:GeothermalArea | Open Energy Information

    Open Energy Info (EERE)

    Area + Babadere Geothermal Project + Tuzla Geothermal Area + Bacman 1 GEPP + Bac-Man Laguna Geothermal Area + Bacman 2 GEPP + Bac-Man Laguna Geothermal Area + Bacman...

  17. Cove Fort Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Cove Fort Geothermal Area (Redirected from Cove Fort Geothermal Area - Vapor) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Cove Fort Geothermal Area Contents 1 Area...

  18. Blue Mountain Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Blue Mountain Geothermal Area (Redirected from Blue Mountain Area) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Blue Mountain Geothermal Area Contents 1 Area...

  19. Stillwater Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Stillwater Geothermal Area (Redirected from Stillwater Area) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Stillwater Geothermal Area Contents 1 Area Overview 2...

  20. Chena Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Chena Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Chena Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 2.1 Chena Area...

  1. Salton Sea Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Salton Sea Geothermal Area (Redirected from Salton Sea Area) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Salton Sea Geothermal Area Contents 1 Area Overview 2...

  2. Heber Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Heber Geothermal Area (Redirected from Heber Area) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Heber Geothermal Area Contents 1 Area Overview 2 History and...

  3. Final environmental impact statement for the construction and operation of an independent spent fuel storage installation to store the Three Mile Island Unit 2 spent fuel at the Idaho National Engineering and Environmental Laboratory. Docket Number 72-20

    SciTech Connect (OSTI)

    1998-03-01

    This Final Environmental Impact Statement (FEIS) contains an assessment of the potential environmental impacts of the construction and operation of an Independent Spent Fuel Storage Installation (ISFSI) for the Three Mile Island Unit 2 (TMI-2) fuel debris at the Idaho National Engineering and Environmental laboratory (INEEL). US Department of Energy-Idaho Operations Office (DOE-ID) is proposing to design, construct, and operate at the Idaho Chemical Processing Plant (ICPP). The TMI-2 fuel debris would be removed from wet storage, transported to the ISFSI, and placed in storage modules on a concrete basemat. As part of its overall spent nuclear fuel (SNF) management program, the US DOE has prepared a final programmatic environmental impact statement (EIS) that provides an overview of the spent fuel management proposed for INEEL, including the construction and operation of the TMI-2 ISFSI. In addition, DOE-ID has prepared an environmental assessment (EA) to describe the environmental impacts associated with the stabilization of the storage pool and the construction/operation of the ISFSI at the ICPP. As provided in NRC`s NEPA procedures, a FEIS of another Federal agency may be adopted in whole or in part in accordance with the procedures outlined in 40 CFR 1506.3 of the regulations of the Council on Environmental Quality (CEQ). Under 40 CFR 1506.3(b), if the actions covered by the original EIS and the proposed action are substantially the same, the agency adopting another agency`s statement is not required to recirculate it except as a final statement. The NRC has determined that its proposed action is substantially the same as actions considered in DOE`s environmental documents referenced above and, therefore, has elected to adopt the DOE documents as the NRC FEIS.

  4. Lower Pennsylvanian reservoirs of Parkway-Empire south field area, Eddy County, New Mexico

    SciTech Connect (OSTI)

    James, A.D.

    1984-01-01

    The Parkway-Empire area is located on the Northwest shelf in central Eddy County, approximately 15 mi (24 km) northeast of Carlsbad, New Mexico. This area produces oil and gas from the lower and middle Morrow sandstones, Atoka sandstones, and Strawn limestones. Oil is also produced from the Queen and Seven Rivers sandstones, and the Grayburg, San Andres, and Wolfcamp dolomites. All of the these zones are productive from stratigraphic traps. The lower Morrow sandstones occur at a depth of about 11,400 ft (3,474 m). In the Parkway area, the middle Morrow sandstones are thought to be a transgressive series of marine beaches and submarine bars which trend toward the northeast, parallel to depositional strike. Stratigraphic traps are created in the lower and middle Morrow sandstones by variations in cementation and depositional patterns. Productive Atoka sandstones occur at a depth of approximately 10,700 ft (3,261 m). Strawn limestones produce from a series of small, low-relief algal banks developed along depositional strike to the northeast. The Strawn limestone is about 300 ft (91 m) thick and occurs between 10,250 and 10,500 ft (3,124 and 3,200 m). Wells in this area have typical ultimate recoveries of between 1.0 and 3.0 bcf of gas. The combination of stacked reservoirs and good production makes this area of the Morrow trend especially attractive.

  5. Geothermal-resource assessment of the Steamboat-Routt Hot Springs area, Colorado. Resources Series 22

    SciTech Connect (OSTI)

    Pearl, R.H.; Zacharakis, T.G.; Ringrose, C.D.

    1983-01-01

    An assessment of the Steamboat Springs region in northwest Colorado was initiated and carried out in 1980 and 1981. The goal of this program was to delineate the geological features controlling the occurrence of the thermal waters (temperatures in excess of 68/sup 0/F (20/sup 0/C)) in this area at Steamboat Springs and 8 miles (12.8 km) north at Routt Hot Springs. Thermal waters from Heart Spring, the only developed thermal water source in the study area, are used in the municipal swimming pool in Steamboat Springs. The assessment program was a fully integrated program consisting of: dipole-dipole, Audio-magnetotelluric, telluric, self potential and gravity geophysical surveys, soil mercury and soil helium geochemical surveys; shallow temperature measurements; and prepartion of geological maps. The investigation showed that all the thermal springs appear to be fault controlled. Based on the chemical composition of the thermal waters it appears that Heart Spring in Steamboat Springs is hydrologically related to the Routt Hot Springs. This relationship was further confirmed when it was reported that thermal waters were encountered during the construction of the new high school in Strawberry Park on the north side of Steamboat Springs. In addition, residents stated that Strawberry Park appears to be warmer than the surrounding country side. Geological mapping has determined that a major fault extends from the Routt Hot Springs area into Strawberry Park.

  6. An aerial radiological survey of the Fernald Environmental Management Project and surrounding area, Fernald, Ohio

    SciTech Connect (OSTI)

    Phoenix, K.A.

    1997-04-01

    An aerial radiological survey was conducted from May 17--22, 1994, over a 36 square mile (93 square kilometer) area centered on the Fernald Environmental Management Project located in Fernald, Ohio. The purpose of the survey was to detect anomalous gamma radiation in the environment surrounding the plant. The survey was conducted at a nominal altitude of 150 feet (46 meters) with a line spacing of 250 feet (76 meters). A contour map of the terrestrial gamma exposure rate extrapolated to 1 meter (3.3 feet) above ground was prepared and overlaid on an aerial photograph of the area. Analysis of the data for man made sources showed five sites within the boundaries of the Fernald Environmental Management Project having elevated readings. The exposure rates outside the plant boundary were typical of naturally occurring background radiation. Soil samples and pressurized ion chamber measurements were obtained at four locations within the survey boundaries to supplement the aerial data. It was concluded that although the radionuclides identified in the high-exposure-rate areas are naturally occurring, the levels encountered are greatly enhanced due to industrial activities at the plant.

  7. An Aerial Radiological Survey of the Portsmouth Gaseous Diffusion Plant and Surrounding Area, Portsmouth, Ohio

    SciTech Connect (OSTI)

    Namdoo Moon

    2007-12-01

    An aerial radiological survey was conducted over the 16 square-mile (~41 square-kilometer) area surrounding the Portsmouth Gaseous Diffusion Plant. The survey was performed in August 2007 utilizing a large array of helicopter mounted sodium iodide detectors. The purpose of the survey was to update the previous radiological survey levels of the environment and surrounding areas of the plant. A search for a missing radium-226 source was also performed. Implied exposure rates, man-made activity, and excess bismuth-214 activity, as calculated from the aerial data are presented in the form of isopleth maps superimposed on imagery of the surveyed area. Ground level and implied aerial exposure rates for nine specific locations are compared. Detected radioisotopes and their associated gamma ray exposure rates were consistent with those expected from normal background emitters. At specific plant locations described in the report, man-made activity was consistent with the operational histories of the location. There was no spectral activity that would indicate the presence of the lost source.

  8. PREFERRED WATERFLOOD MANAGEMENT PRACTICES FOR THE SPRABERRY TREND AREA

    SciTech Connect (OSTI)

    C. M. Sizemore; David S. Schechter

    2003-08-13

    This report describes the work performed during the second year of the project, ''Preferred Waterflood Management Practices for the Spraberry Trend Area''. The objective of this project is to significantly increase field-wide production in the Spraberry Trend in a short time frame through the application of preferred practices for managing and optimizing water injection. Our goal is to dispel negative attitudes and lack of confidence in water injection and to document the methodology and results for public dissemination to motivate waterflood expansion in the Spraberry Trend. To achieve this objective, in this period we concentrated our effort on characterization of Germania Unit using an analog field ET ODaniel unit and old cased hole neutron. Petrophysical Characterization of the Germania Spraberry units requires a unique approach for a number of reasons--limited core data, lack of modern log data and absence of directed studies within the unit. The need for characterization of the Germania unit has emerged as a first step in the review, understanding and enhancement of the production practices applicable within the unit and the trend area in general. In the absence or lack of the afore mentioned resources, an approach that will rely heavily on previous petrophysical work carried out in the neighboring ET O'Daniel unit (6.2 miles away), and normalization of the old log data prior to conventional interpretation techniques will be used. A log-based rock model has been able to guide successfully the prediction of pay and non-pay intervals within the ET O'Daniel unit, and will be useful if found applicable within the Germania unit. A novel multiple regression technique utilizing non-parametric transformations to achieve better correlations in predicting a dependent variable (permeability) from multiple independent variables (rock type, shale volume and porosity) will also be investigated in this study. A log data base includes digitized formats of Gamma Ray, Cased

  9. Tech Area II: A history

    SciTech Connect (OSTI)

    Ullrich, R.

    1998-07-01

    This report documents the history of the major buildings in Sandia National Laboratories` Technical Area II. It was prepared in support of the Department of Energy`s compliance with Section 106 of the National Historic Preservation Act. Technical Area II was designed and constructed in 1948 specifically for the final assembly of the non-nuclear components of nuclear weapons, and was the primary site conducting such assembly until 1952. Both the architecture and location of the oldest buildings in the area reflect their original purpose. Assembly activities continued in Area II from 1952 to 1957, but the major responsibility for this work shifted to other sites in the Atomic Energy Commission`s integrated contractor complex. Gradually, additional buildings were constructed and the original buildings were modified. After 1960, the Area`s primary purpose was the research and testing of high-explosive components for nuclear weapons. In 1994, Sandia constructed new facilities for work on high-explosive components outside of the original Area II diamond-shaped parcel. Most of the buildings in the area are vacant and Sandia has no plans to use them. They are proposed for decontamination and demolition as funding becomes available.

  10. Why SRS Matters - L Area

    SciTech Connect (OSTI)

    Hunt, Paul

    2015-01-28

    A video series presenting an overview of the Savannah River Site's (SRS) mission and operations. Each episode features a specific area/operation and how it contributes to help make the world safer. This episode features L Area's mission and operations.

  11. Why SRS Matters - E Area

    SciTech Connect (OSTI)

    Howell, Steve; Mooneyhan, Verne; Tempel, Kevin; Bullington, Michele

    2015-03-09

    A video series presenting an overview of the Savannah River Site's (SRS) mission and operations. Each episode features a specific area/operation and how it contributes to help make the world safer. This episode features E Area's mission and operations.

  12. Why SRS Matters - F Area

    SciTech Connect (OSTI)

    Howell, Steve; Tadlock, Bill; Beeler, Dewitt; Gardner, Curt

    2015-02-17

    A video series presenting an overview of the Savannah River Site's (SRS) mission and operations. Each episode features a specific area/operation and how it contributes to help make the world safer. This episode features F Area's mission and operations.

  13. AREA

    Broader source: Energy.gov (indexed) [DOE]

    or if they need to add this to their audit they have performed yearly by a public accounting firm. 316 audits are essentially A-133 audits for for-profit entities. They DO...

  14. AREA

    Office of Environmental Management (EM)

    DCAA would never agree to perform A-133 or our 316 audits. They don't do A-133 audits for DOD awardees. The purpose of the audits are different, look at different things and in the ...

  15. Evaluation of Multiplexed 16S rRNA Microbial Population Surveys Using Illumina MiSeq Platform (Seventh Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting 2012)

    ScienceCinema (OSTI)

    Tremblay, Julien [DOE JGI

    2013-01-25

    Julien Tremblay from DOE JGI presents "Evaluation of Multiplexed 16S rRNA Microbial Population Surveys Using Illumina MiSeq Platorm" at the 7th Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting held in June, 2012 in Santa Fe, NM.

  16. A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Nagarkar-Jaiswal, Sonal; Lee, Pei-Tseng; Campbell, Megan E.; Chen, Kuchuan; Anguiano-Zarate, Stephanie; Cantu Gutierrez, Manuel; Busby, Theodore; Lin, Wen-Wen; He, Yuchun; Schulze, Karen L.; et al

    2015-03-31

    Here, we document a collection of ~7434 MiMIC (Minos Mediated Integration Cassette) insertions of which 2854 are inserted in coding introns. They allowed us to create a library of 400 GFP-tagged genes. We show that 72% of internally tagged proteins are functional, and that more than 90% can be imaged in unfixed tissues. Moreover, the tagged mRNAs can be knocked down by RNAi against GFP (iGFPi), and the tagged proteins can be efficiently knocked down by deGradFP technology. The phenotypes associated with RNA and protein knockdown typically correspond to severe loss of function or null mutant phenotypes. Finally, we demonstratemore » reversible, spatial, and temporal knockdown of tagged proteins in larvae and adult flies. This new strategy and collection of strains allows unprecedented in vivo manipulations in flies for many genes. These strategies will likely extend to vertebrates.« less

  17. A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila

    SciTech Connect (OSTI)

    Nagarkar-Jaiswal, Sonal; Lee, Pei-Tseng; Campbell, Megan E.; Chen, Kuchuan; Anguiano-Zarate, Stephanie; Cantu Gutierrez, Manuel; Busby, Theodore; Lin, Wen-Wen; He, Yuchun; Schulze, Karen L.; Booth, Benjamin W.; Evans-Holm, Martha; Venken, Koen J.T.; Levis, Robert W.; Spradling, Allan C.; Hoskins, Roger A.; Bellen, Hugo J.

    2015-03-31

    Here, we document a collection of ~7434 MiMIC (Minos Mediated Integration Cassette) insertions of which 2854 are inserted in coding introns. They allowed us to create a library of 400 GFP-tagged genes. We show that 72% of internally tagged proteins are functional, and that more than 90% can be imaged in unfixed tissues. Moreover, the tagged mRNAs can be knocked down by RNAi against GFP (iGFPi), and the tagged proteins can be efficiently knocked down by deGradFP technology. The phenotypes associated with RNA and protein knockdown typically correspond to severe loss of function or null mutant phenotypes. Finally, we demonstrate reversible, spatial, and temporal knockdown of tagged proteins in larvae and adult flies. This new strategy and collection of strains allows unprecedented in vivo manipulations in flies for many genes. These strategies will likely extend to vertebrates.

  18. Vital area analysis using sets

    SciTech Connect (OSTI)

    Stack, D.W.; Francis, K.A.

    1980-05-01

    This report describes the use of the Set Equation Transformation System (SETS) for vital area analysis. Several concepts are introduced which enable the analyst to construct more efficient SETS user programs to perform vital area analysis. The advantages of performing the transformation of variables without first determining the minimal cut sets of the fault tree are discussed. A ''bottom-up'' approach to solving a fault tree is presented. The techniques described for vital area analysis are also suitable and efficient for many kinds of common cause analysis.

  19. HISTORICAL AMERICAN ENGINEERING RECORD - IDAHO NATIONAL ENGINEERING AND ENVIRONMENTAL LABORATORY, TEST AREA NORTH, HAER NO. ID-33-E

    SciTech Connect (OSTI)

    Susan Stacy; Hollie K. Gilbert

    2005-02-01

    Test Area North (TAN) was a site of the Aircraft Nuclear Propulsion (ANP) Project of the U.S. Air Force and the Atomic Energy Commission. Its Cold War mission was to develop a turbojet bomber propelled by nuclear power. The project was part of an arms race. Test activities took place in five areas at TAN. The Assembly & Maintenance area was a shop and hot cell complex. Nuclear tests ran at the Initial Engine Test area. Low-power test reactors operated at a third cluster. The fourth area was for Administration. A Flight Engine Test facility (hangar) was built to house the anticipated nuclear-powered aircraft. Experiments between 1955-1961 proved that a nuclear reactor could power a jet engine, but President John F. Kennedy canceled the project in March 1961. ANP facilities were adapted for new reactor projects, the most important of which were Loss of Fluid Tests (LOFT), part of an international safety program for commercial power reactors. Other projects included NASA's Systems for Nuclear Auxiliary Power and storage of Three Mile Island meltdown debris. National missions for TAN in reactor research and safety research have expired; demolition of historic TAN buildings is underway.

  20. Manhattan Project: Tech Area Gallery

    Office of Scientific and Technical Information (OSTI)

    All of the photographs below are of the "Tech Area" at Los Alamos during or shortly after the wartime years. If you have a fast internet connection, you may wish to click here for ...

  1. Fire in a contaminated area

    SciTech Connect (OSTI)

    Ryan, G.W., Westinghouse Hanford

    1996-08-28

    This document supports the development and presentation of the following accident scenario in the TWRS Final Safety Analysis Report: Fire in Contaminated Area. The calculations needed to quantify the risk associated with this accident scenario are included within.

  2. Progress Update: M Area Closure

    ScienceCinema (OSTI)

    Cody, Tom

    2012-06-14

    A progress update of the Recovery Act at work at the Savannah River Site. The celebration of the first area cleanup completion with the help of the Recovery Act.

  3. CENTRAL NEVPJJA SUPPLEMENTAL TEST AREA

    Office of Legacy Management (LM)

    CENTRAL NEVPJJA SUPPLEMENTAL TEST AREA ,FACILITY RECORDS 1970 UNITED STATES ATOMIC ENERGY ... Prepared By Holmes & Narver. Inc. On-Continent Test Division P.O. Box 14340 Las Vegas, ...

  4. Security Area Vouching and Piggybacking

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2000-06-05

    Establishes requirements for the Department of Energy (DOE) Security Area practice of "vouching" or "piggybacking" access by personnel. DOE N 251.40, dated 5-3-01, extends this directive until 12-31-01.

  5. Manhattan Project: Tech Area Gallery

    Office of Scientific and Technical Information (OSTI)

    All of the photographs below are of the "Tech Area" at Los Alamos during or shortly after the wartime years. If this page is taking a long time to load, click here for a photo ...

  6. Focus Areas | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Focus Areas Focus Areas Safety With this focus on cleanup completion and risk reducing results, safety still remains the utmost priority. EM will continue to maintain and demand the highest safety performance. All workers deserve to go home as healthy as they were when they came to the job in the morning. There is no schedule or milestone worth any injury to the work force. Project Management EM is increasing its concentration on project management to improve its overall performance toward

  7. Variable area fuel cell cooling

    DOE Patents [OSTI]

    Kothmann, Richard E.

    1982-01-01

    A fuel cell arrangement having cooling fluid flow passages which vary in surface area from the inlet to the outlet of the passages. A smaller surface area is provided at the passage inlet, which increases toward the passage outlet, so as to provide more uniform cooling of the entire fuel cell. The cooling passages can also be spaced from one another in an uneven fashion.

  8. Carlsbad Area Office Executive Summary

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    June 1998 Carlsbad Area Office Executive Summary The mission of the Carlsbad Area Office (CAO) is to protect human health and the environment by opening and operating the Waste Isolation Pilot Plant (WIPP) for safe disposal of transuranic (TRU) waste and by establishing an effective system for management of TRU waste from generation to disposal. It includes personnel assigned to CAO, WIPP site operations, transportation, and other activities associated with the National TRU Program (NTP). The

  9. Research Subject Areas for IGPPS Proposals

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research Subject Areas Research Subject Areas for IGPPS Proposals High quality, cutting-edge science in the areas of astrophysics, space physics, solid planetary geoscience, and...

  10. Java - Dieng Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Java - Dieng Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Java - Dieng Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 3...

  11. Java - Kamojang Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Java - Kamojang Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Java - Kamojang Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 3...

  12. Java - Darajat Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Java - Darajat Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Java - Darajat Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 3...

  13. Great Basin Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Great Basin Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Great Basin Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 3...

  14. Sacramento Area Technology Alliance | Open Energy Information

    Open Energy Info (EERE)

    Sacramento Area Technology Alliance Jump to: navigation, search Logo: Sacramento Area Technology Alliance Name: Sacramento Area Technology Alliance Address: 5022 Bailey Loop Place:...

  15. Wild Rose Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Wild Rose Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Wild Rose Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 3 Regulatory...

  16. Butte Springs Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Butte Springs Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Butte Springs Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 3...

  17. Chocolate Mountains Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Chocolate Mountains Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Chocolate Mountains Geothermal Area Contents 1 Area Overview 2 History and...

  18. Mcgee Mountain Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Mcgee Mountain Geothermal Area (Redirected from Mcgee Mountain Area) Redirect page Jump to: navigation, search REDIRECT McGee Mountain Geothermal Area Retrieved from "http:...

  19. Alum Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Alum Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Alum Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 3 Regulatory and...

  20. Aurora Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Aurora Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Aurora Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 3 Regulatory and...

  1. Berln Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Berln Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Berln Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 3 Regulatory and...

  2. Stillwater Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Stillwater Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Stillwater Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 3...

  3. Krafla Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Krafla Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Krafla Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 3 Regulatory and...

  4. Salt Wells Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Salt Wells Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Salt Wells Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 2.1 Salt...

  5. Rye Patch Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Rye Patch Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Rye Patch Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 3 Regulatory...

  6. Amedee Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Amedee Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Amedee Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 3 Regulatory and...

  7. Miravalles Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Miravalles Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Miravalles Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 3...

  8. Oita Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Oita Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Oita Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 3 Regulatory and...

  9. Cove Fort Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Cove Fort Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Cove Fort Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 3 Regulatory...

  10. Geysers Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Geysers Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Geysers Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 3 Regulatory and...

  11. Larderello Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Larderello Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Larderello Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 3...

  12. Dixie Valley Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Field Area) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Dixie Valley Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 2.1 U.S. Department...

  13. Dixie Valley Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Dixie Valley Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Dixie Valley Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 2.1...

  14. Geothermal resource area 11, Clark County area development plan

    SciTech Connect (OSTI)

    Pugsley, M.

    1981-01-01

    Geothermal Resource Area 11 includes all of the land in Clark County, Nevada. Within this area are nine geothermal anomalies: Moapa Area, Las Vegas Valley, Black Canyon, Virgin River Narrows, Roger's Springs, Indian Springs, White Rock Springs, Brown's Spring, and Ash Creek Spring. All of the geothermal resources in Clark County have relatively low temperatures. The highest recorded temperature is 145{sup 0}F at Black Canyon. The temperatures of the other resources range from 70 to 90{sup 0}F. Because of the low temperature of the resources and, for the most part, the distance of the resources from any population base, the potential for the development of the resources are considered to be somewhat limited.

  15. Area Lodging: Oak Ridge | Y-12 National Security Complex

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    37830 865.483.5615 (1.800.544.8313) fax 865.483.5615 1.7 miles from Y-12 DoubleTree Hotel 215 South Illinois Avenue Oak Ridge, TN 37830 865.481.2468; 1.800.222.8733...

  16. Repression of miR-17-5p with elevated expression of E2F-1 and c-MYC in non-metastatic hepatocellular carcinoma and enhancement of cell growth upon reversing this expression pattern

    SciTech Connect (OSTI)

    El Tayebi, H.M.; Omar, K.; Hegy, S.; El Maghrabi, M.; El Brolosy, M.; Hosny, K.A.; Esmat, G.; Abdelaziz, A.I.

    2013-05-10

    Highlights: The oncogenic miR-17-5p is downregulated in non-metastatic hepatocellular carcinoma patients. E2F-1 and c-MYC transcripts are upregulated in non-metastatic HCC patients. miR-17-5p forced overexpression inhibited E2F-1 and c-MYC expression in HuH-7 cells. miR-17-5p mimicking increased HuH-7 cell growth, proliferation, migration and colony formation. miR-17-5p is responsible for HCC progression among the c-MYC/E2F-1/miR-17-5p triad members. -- Abstract: E2F-1, c-MYC, and miR-17-5p is a triad of two regulatory loops: a negative and a positive loop, where c-MYC induces the expression of E2F-1 that induces the expression of miR-17-5p which in turn reverses the expression of E2F-1 to close the loop. In this study, we investigated this triad for the first time in hepatocellular carcinoma (HCC), where miR-17-5p showed a significant down-regulation in 23 non-metastatic HCC biopsies compared to 10 healthy tissues; however, E2F-1 and c-MYC transcripts were markedly elevated. Forced over-expression of miR-17-5p in HuH-7 cells resulted in enhanced cell proliferation, growth, migration and clonogenicity with concomitant inhibition of E2F-1 and c-MYC transcripts expressions, while antagomirs of miR-17-5p reversed these events. In conclusion, this study revealed a unique pattern of expression for miR-17-5p in non-metastatic HCC patients in contrast to metastatic HCC patients. In addition we show that miR-17-5p is the key player among the triad that tumor growth and spread.

  17. Los Humeros Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    (0) 10 References Area Overview Geothermal Area Profile Location: Chignautla, Puebla, Mexico Exploration Region: Transmexican Volcanic Belt GEA Development Phase:...

  18. H-Area Seepage Basins

    SciTech Connect (OSTI)

    Stejskal, G.

    1990-12-01

    During the third quarter of 1990 the wells which make up the H-Area Seepage Basins (H-HWMF) monitoring network were sampled. Laboratory analyses were performed to measure levels of hazardous constituents, indicator parameters, tritium, nonvolatile beta, and gross alpha. A Gas Chromatograph Mass Spectrometer (GCMS) scan was performed on all wells sampled to determine any hazardous organic constituents present in the groundwater. The primary contaminants observed at wells monitoring the H-Area Seepage Basins are tritium, nitrate, mercury, gross alpha, nonvolatile beta, trichloroethylene (TCE), tetrachloroethylene, lead, cadmium, arsenic, and total radium.

  19. AreaMapWeb copy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ORNL ETTP CITY OF OAK RIDGE MAP AREA (below) 170 170 62 162 162 62 62 61 61 62 61 95 95 61 61 58 95 62 129 321 411 411 321 321 129 11W 11E 11 70 11 11 70 11 11 70 70 40 40 140 140 40 75 40 40 40 640 640 75 75 75 75 61 62 ALCOA MARYVILLE LENOIR CITY FARRAGUT LOUDON OLIVER SPRINGS OAK RIDGE KNOXVILLE AIRPORT McGhee Tyson Municipal Airport (Knoxville Airport) Route between Knoxville Airport, Downtown Knoxville, and Oak Ridge area Take left lane for I-40 West to Nashville, Chattanooga No. 376A Oak

  20. Marine carbonate embayment system in an Eolian dune terrain, Permian Upper Minnelusa Formation, Rozet Area, Powder River Basin, Wyoming

    SciTech Connect (OSTI)

    Achauer, C.W.

    1987-05-01

    The eolian origin for Minnelusa sandstones has been stressed in numerous published articles. However, the dolomites that are interbedded with the eolian sandstones have received little attention. Isopach mapping of one of the dolomite units (Dolomite I) reflects a marine embayment system whose individual embayments range from 1/2 to 1 mi in width and trend primarily in a northwest direction. Consistently the embayment dolomites pinch out against the flanks of reworked, low relief, broad, eolian dune ridges. So far, 108 mi/sup 2/ of the Dolomite I marine embayment system have been mapped, but the overall extent of the system is undoubtedly much greater. Dolomite I is rarely cored, but cores from stratigraphically higher embayment dolomites in the upper Minnelusa show that these dolomites display the following, shoaling-upward sequence: (1) subtidal, sparingly fossiliferous dolomite; (2) intertidal, algal-laminated or brecciated or mud-cracked dolomite; and (3) very thin, supratidal, nodular anhydrite. The embayments, therefore, became the sites of marine sabkhas located between eolian dunes. Two main conclusions emerge from this study: (1) the juxtaposition of eolian sandstones and marine dolomites in a tectonically stable area suggests that eustatic sea level changes and a very arid climate were responsible for the marked environmental and lithologic changes observed in the upper Minnelusa, and (2) arid, coastal, evaporitic sabkhas bordered by eolian dunes are known from a number of modern and ancient cases, but marine carbonate embayments and associated evaporitic sabkhas that penetrate deeply into eolian sandstone terrains are rare.

  1. Resonances in Coupled <mimi><mi>Kmi>-<mi>ηK> Scattering from Quantum Chromodynamics

    SciTech Connect (OSTI)

    Dudek, Jozef J.; Edwards, Robert G.; Thomas, Christopher E.; Wilson, David J.

    2014-10-01

    Using first-principles calculation within Quantum Chromodynamics, we are able to reproduce the pattern of experimental strange resonances which appear as complex singularities within coupled πK, ηK scattering amplitudes. We make use of numerical computation within the lattice discretized approach to QCD, extracting the energy dependence of scattering amplitudes through their relation- ship to the discrete spectrum of the theory in a finite-volume, which we map out in unprecedented detail.

  2. 200 area TEDF sample schedule

    SciTech Connect (OSTI)

    Brown, M.J.

    1995-03-22

    This document summarizes the sampling criteria associated with the 200 Area Treatment Effluent Facility (TEDF) that are needed to comply with the requirements of the Washington State Discharge Permit No. WA ST 4502 and good engineering practices at the generator streams that feed into TEDF. In addition, this document Identifies the responsible parties for both sampling and data transference.

  3. Facility Closure Report for T-Tunnel (U12t), Area 12, Nevada Test Site, Nevada

    SciTech Connect (OSTI)

    NSTec Environmental Restoration

    2008-08-01

    This Facility Closure Report (FCR) has been prepared to document the actions taken to permanently close the remaining accessible areas of U12t-Tunnel (T-Tunnel) in Area 12 of the Nevada Test Site (NTS). The closure of T-Tunnel was a prerequisite to transfer facility ownership from the Defense Threat Reduction Agency (DTRA) to the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO). Closure of the facility was accomplished with the cooperation and concurrence of both NNSA/NSO and the Nevada Division of Environmental Protection (NDEP). The purpose of this FCR is to document that the closure of T-Tunnel complied with the closure requirements specified in the Facility Closure Plan for N- and T-Tunnels Area 12, Nevada Test Site (Appendix D) and that the facility is ready for transfer to NNSA/NSO. The Facility Closure Plan (FCP) is provided in Appendix D. T-Tunnel is located approximately 42 miles north of Mercury in Area 12 of the NTS (Figure 1). Between 1970 and 1987, T-Tunnel was used for six Nuclear Weapons Effects Tests (NWETs). The tunnel was excavated horizontally into the volcanic tuffs of Rainier Mesa. The T-Tunnel complex consists of a main access drift with two NWET containment structures, a Gas Seal Plug (GSP), and a Gas Seal Door (GSD) (Figure 2). The T-Tunnel complex was mothballed in 1993 to preserve the tunnel for resumption of testing, should it happen in the future, to stop the discharge of tunnel effluent, and to prevent unauthorized access. This was accomplished by sealing the main drift GSD.

  4. A study of muon neutrino disappearance with the MINOS detectors and the NuMI neutrino beam

    SciTech Connect (OSTI)

    Marshall, John Stuart; /Cambridge U.

    2008-06-01

    This thesis presents the results of an analysis of {nu}{sub {mu}} disappearance with the MINOS experiment, which studies the neutrino beam produced by the NuMI facility at Fermi National Accelerator Laboratory. The rates and energy spectra of charged current {nu}{sub {mu}} interactions are measured in two similar detectors, located at distances of 1 km and 735 km along the NuMI beamline. The Near Detector provides accurate measurements of the initial beam composition and energy, while the Far Detector is sensitive to the effects of neutrino oscillations. The analysis uses data collected between May 2005 and March 2007, corresponding to an exposure of 2.5 x 10{sup 20} protons on target. As part of the analysis, sophisticated software was developed to identify muon tracks in the detectors and to reconstruct muon kinematics. Events with reconstructed tracks were then analyzed using a multivariate technique to efficiently isolate a pure sample of charged current {nu}{sub {mu}} events. An extrapolation method was also developed, which produces accurate predictions of the Far Detector neutrino energy spectrum, based on data collected at the Near Detector. Finally, several techniques to improve the sensitivity of an oscillation measurement were implemented, and a full study of the systematic uncertainties was performed. Extrapolating from observations at the Near Detector, 733 {+-} 29 Far Detector events were expected in the absence of oscillations, but only 563 events were observed. This deficit in event rate corresponds to a significance of 4.3 standard deviations. The deficit is energy dependent and clear distortion of the Far Detector energy spectrum is observed. A maximum likelihood analysis, which fully accounts for systematic uncertainties, is used to determine the allowed regions for the oscillation parameters and identifies the best fit values as {Delta}m{sub 32}{sup 2} = 2.29{sub -0.14}{sup +0.14} x 10{sup -3} eV{sup 2} and sin{sup 2} 2{theta}{sub 23} > 0

  5. MI C H I GA N M E M O R I A L P H O E N I X PROJECT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    M M P P - N P C - I - 4 MI C H I GA N M E M O R I A L P H O E N I X PROJECT THE U N I V E R S I T Y OF MI CHI GAN Facsimile Price $ Ij) Microfilm Price $ y / Avoiloble from the O ffic e of Technical Services Department o f Commerce Washington 25, D. C. LATTICE W A VES, SPIN W AVES A N D NEUTRON SCATTERING By B. N . BROCKHOUSE CHALK RIVER PROJECT A T O M IC ENERGY O F C A N A D A LIMITED A PAPER BASED O N LECTURES PRESENTED AT THE NEUTRON PHYSICS CONFERENCE M A C K IN A C ISLAND, M IC H IG A N JU

  6. Areas Participating in the Reformulated Gasoline Program

    Gasoline and Diesel Fuel Update (EIA)

    Reformulated Gasoline Program Contents * Introduction * Mandated RFG Program Areas o Table 1. Mandated RFG Program Areas * RFG Program Opt-In Areas o Table 2. RFG Program Opt-In Areas * RFG Program Opt-Out Procedures and Areas o Table 3. History of EPA Rulemaking on Opt-Out Procedures o Table 4. RFG Program Opt-Out Areas * State Programs o Table 5. State Reformulated Gasoline Programs * Endnotes Spreadsheets Referenced in this Article * Reformulated Gasoline Control Area Populations Related EIA

  7. Variable area light reflecting assembly

    DOE Patents [OSTI]

    Howard, T.C.

    1986-12-23

    Device is described for tracking daylight and projecting it into a building. The device tracks the sun and automatically adjusts both the orientation and area of the reflecting surface. The device may be mounted in either a wall or roof of a building. Additionally, multiple devices may be employed in a light shaft in a building, providing daylight to several different floors. The preferred embodiment employs a thin reflective film as the reflecting device. One edge of the reflective film is fixed, and the opposite end is attached to a spring-loaded take-up roller. As the sun moves across the sky, the take-up roller automatically adjusts the angle and surface area of the film. Additionally, louvers may be mounted at the light entrance to the device to reflect incoming daylight in an angle perpendicular to the device to provide maximum reflective capability when daylight enters the device at non-perpendicular angles. 9 figs.

  8. Variable area light reflecting assembly

    DOE Patents [OSTI]

    Howard, Thomas C.

    1986-01-01

    Device for tracking daylight and projecting it into a building. The device tracks the sun and automatically adjusts both the orientation and area of the reflecting surface. The device may be mounted in either a wall or roof of a building. Additionally, multiple devices may be employed in a light shaft in a building, providing daylight to several different floors. The preferred embodiment employs a thin reflective film as the reflecting device. One edge of the reflective film is fixed, and the opposite end is attached to a spring-loaded take-up roller. As the sun moves across the sky, the take-up roller automatically adjusts the angle and surface area of the film. Additionally, louvers may be mounted at the light entrance to the device to reflect incoming daylight in an angle perpendicular to the device to provide maximum reflective capability when daylight enters the device at non-perpendicular angles.

  9. Microfluidic molecular assay platform for the detection of miRNAs, mRNAs, proteins, and post-translational modifications at single-cell resolution

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Wu, Meiye; Singh, Anup K.

    2014-07-15

    In this study, cell signaling is a dynamic and complex process. A typical signaling pathway may begin with activation of cell surface receptors, leading to activation kinase cascade that culminates in induction of mRNA and non-coding miRNA production in the nucleus, followed by modulation of mRNA expression by miRNAs in the cytosol, and end with production of proteins in response to the signaling pathway. Signaling pathways involve proteins, miRNA, and mRNAs, along with various forms of transient post-translational modifications, and detecting each type of signaling molecule requires categorically different sample preparation methods such as Western blotting for proteins, PCR formore » nucleic acids, and flow cytometry for post-translational modifications. Since we know that cells in populations behave heterogeneously1, especially in the cases of stem cells, cancer, and hematopoiesis, there is need for a new technology that provides capability to detect and quantify multiple categories of signaling molecules in intact single cells to provide a comprehensive view of the cell’s physiological state. In this technical brief, we describe our microfluidic platform with a portfolio of customized molecular assays that can detect nucleic acids, proteins, and post-translational modifications in single intact cells with >95% reduction in reagent requirement in under 8 hours.« less

  10. Microfluidic molecular assay platform for the detection of miRNAs, mRNAs, proteins, and post-translational modifications at single-cell resolution

    SciTech Connect (OSTI)

    Wu, Meiye; Singh, Anup K.

    2014-07-15

    In this study, cell signaling is a dynamic and complex process. A typical signaling pathway may begin with activation of cell surface receptors, leading to activation kinase cascade that culminates in induction of mRNA and non-coding miRNA production in the nucleus, followed by modulation of mRNA expression by miRNAs in the cytosol, and end with production of proteins in response to the signaling pathway. Signaling pathways involve proteins, miRNA, and mRNAs, along with various forms of transient post-translational modifications, and detecting each type of signaling molecule requires categorically different sample preparation methods such as Western blotting for proteins, PCR for nucleic acids, and flow cytometry for post-translational modifications. Since we know that cells in populations behave heterogeneously1, especially in the cases of stem cells, cancer, and hematopoiesis, there is need for a new technology that provides capability to detect and quantify multiple categories of signaling molecules in intact single cells to provide a comprehensive view of the cell’s physiological state. In this technical brief, we describe our microfluidic platform with a portfolio of customized molecular assays that can detect nucleic acids, proteins, and post-translational modifications in single intact cells with >95% reduction in reagent requirement in under 8 hours.

  11. Microfluidic Molecular Assay Platform for the Detection of miRNAs, mRNAs, Proteins, and Posttranslational Modifications at Single-Cell Resolution

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Wu, Meiye; Singh, Anup K.

    2014-07-15

    Cell signaling is a dynamic and complex process. A typical signaling pathway may begin with activation of cell surface receptors, leading to activation kinase cascade that culminates in induction of mRNA and non-coding miRNA production in the nucleus, followed by modulation of mRNA expression by miRNAs in the cytosol, and end with production of proteins in response to the signaling pathway. Signaling pathways involve proteins, miRNA, and mRNAs, along with various forms of transient post-translational modifications, and detecting each type of signaling molecule requires categorically different sample preparation methods such as Western blotting for proteins, PCR for nucleic acids, andmoreflow cytometry for post-translational modifications. Since we know that cells in populations behave heterogeneously1, especially in the cases of stem cells, cancer, and hematopoiesis, there is need for a new technology that provides capability to detect and quantify multiple categories of signaling molecules in intact single cells to provide a comprehensive view of the cells physiological state. In this technical brief, we describe our microfluidic platform with a portfolio of customized molecular assays that can detect nucleic acids, proteins, and post-translational modifications in single intact cells with >95% reduction in reagent requirement in under 8 hours.less

  12. Final DOE Areas Feasibility Study

    Office of Legacy Management (LM)

    Management, Washington, DC Weiss Associates Environmental Science, Engineering and Management FINAL DOE AREAS FEASIBILITY STUDY for the: LABORATORY FOR ENERGY-RELATED HEALTH RESEARCH UNIVERSITY OF CALIFORNIA, DAVIS Prepared for: SM Stoller Corporation 2597 B ¾ Road Grand Junction, Colorado 81503 Prepared by: Weiss Associates 5801 Christie Avenue, Suite 600 Emeryville, California 94608-1827 March 07, 2008 Rev. 0 J:\DOE_STOLLER\4110\143\FEASIBILITY_STUDY\20080307_FS_TEXT_REV0.DOC WEISS ASSOCIATES

  13. Innovation investment area: Technology summary

    SciTech Connect (OSTI)

    Not Available

    1994-03-01

    The mission of Environmental Management`s (EM) Office of Technology Development (OTD) Innovation Investment Area is to identify and provide development support for two types of technologies that are developed to characterize, treat and dispose of DOE waste, and to remediate contaminated sites. They are: technologies that show promise to address specific EM needs, but require proof-of-principle experimentation; and (2) already proven technologies in other fields that require critical path experimentation to demonstrate feasibility for adaptation to specific EM needs. The underlying strategy is to ensure that private industry, other Federal Agencies, universities, and DOE National Laboratories are major participants in developing and deploying new and emerging technologies. To this end, about 125 different new and emerging technologies are being developed through Innovation Investment Area`s (IIA) two program elements: RDDT&E New Initiatives (RD01) and Interagency Agreements (RD02). Both of these activities are intended to foster research and development partnerships so as to introduce innovative technologies into other OTD program elements for expedited evaluation.

  14. EA-1177: Salvage/Demolition of 200 West Area, 200 East Area, and 300 Area Steam Plants, Richland, Washington

    Broader source: Energy.gov [DOE]

    This EA evaluates the environmental impacts for the proposal to salvage and demolish the 200 West Area, 200 East Area, and 300 Area steam plants and their associated steam distribution piping...

  15. Nevada Geothermal Area | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Nevada Geothermal Area Nevada Geothermal Area The extensive Steamboat Springs geothermal area contains three geothermal power-generating plants. The plants provide approximately 30% of the total Nevada geothermal power output. Photo of Nevada power plant

  16. Southern CA Area | Open Energy Information

    Open Energy Info (EERE)

    CA Area Jump to: navigation, search Contents 1 Clean Energy Clusters in the Southern CA Area 1.1 Products and Services in the Southern CA Area 1.2 Research and Development...

  17. Fenton Hill Hdr Area | Open Energy Information

    Open Energy Info (EERE)

    Hill Hdr Area Redirect page Jump to: navigation, search REDIRECT Fenton Hill Hdr Geothermal Area Retrieved from "http:en.openei.orgwindex.php?titleFentonHillHdrArea&oldid...

  18. Carlsbad Area Office strategic plan

    SciTech Connect (OSTI)

    NONE

    1995-10-01

    This edition of the Carlsbad Area Office Strategic Plan captures the U.S. Department of Energy`s new focus, and supercedes the edition issued previously in 1995. This revision reflects a revised strategy designed to demonstrate compliance with environmental regulations earlier than the previous course of action; and a focus on the selected combination of scientific investigations, engineered alternatives, and waste acceptance criteria for supporting the compliance applications. An overview of operations and historical aspects of the Waste Isolation Pilot Plant near Carlsbad, New Mexico is presented.

  19. Outdoor Area Lighting | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    for outdoor areas. Outdoor Area Lighting (June 2008) More Documents & Publications Philadelphia International Airport Apron Lighting: LED System Performance in a Trial...

  20. Western Area Power Administration | Open Energy Information

    Open Energy Info (EERE)

    Western Area Power Administration Jump to: navigation, search Name: Western Area Power Administration Place: Colorado Phone Number: 720-962-7000 Website: ww2.wapa.govsites...

  1. Canby Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Area Overview Geothermal Area Profile Location: California Exploration Region: Transition Zone GEA Development Phase: Coordinates: 41.438, -120.8676 Resource Estimate...

  2. Research Areas | National Nuclear Security Administration | ...

    National Nuclear Security Administration (NNSA)

    Magnetized High Energy Density Plasma Physics Specific areas of interest include, but are ... Nonlinear Optics of Plasmas and Laser-Plasma Interactions Specific areas of interest ...

  3. AREA USA LLC | Open Energy Information

    Open Energy Info (EERE)

    AREA USA LLC Jump to: navigation, search Name: AREA USA LLC Place: Washington, DC Zip: 20004 Sector: Services Product: Washington, D.C.-based division of Fabiani & Company...

  4. Socorro Mountain Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Contents 1 Area Overview 2 History and Infrastructure 3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid...

  5. La Primavera Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Contents 1 Area Overview 2 History and Infrastructure 3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid...

  6. Florida Mountains Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Contents 1 Area Overview 2 History and Infrastructure 3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid...

  7. Jemez Mountain Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Contents 1 Area Overview 2 History and Infrastructure 3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid...

  8. Cerro Prieto Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Contents 1 Area Overview 2 History and Infrastructure 3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid...

  9. Jemez Pueblo Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Contents 1 Area Overview 2 History and Infrastructure 3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid...

  10. Jemez Springs Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Contents 1 Area Overview 2 History and Infrastructure 3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid...

  11. Los Azufres Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Contents 1 Area Overview 2 History and Infrastructure 3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid...

  12. Area Science Park | Open Energy Information

    Open Energy Info (EERE)

    Area Science Park Jump to: navigation, search Name: Area Science Park Place: Italy Sector: Services Product: General Financial & Legal Services ( Government Public sector )...

  13. Kizildere Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Activities (0) 10 References Area Overview Geothermal Area Profile Location: Denizli, Turkey Exploration Region: Aegean-West Anatolian Extensional Province - Western Anatolian...

  14. East Brawley Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Area Overview Geothermal Area Profile Location: California Exploration Region: Gulf of California Rift Zone GEA Development Phase: Coordinates: 32.99, -115.35 Resource...

  15. New River Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Area Overview Geothermal Area Profile Location: California Exploration Region: Gulf of California Rift Zone GEA Development Phase: Resource Estimate Mean Reservoir Temp:...

  16. Ahuachapan Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Activities (0) 10 References Area Overview Geothermal Area Profile Location: El Salvador Exploration Region: Central American Volcanic Arc Chain GEA Development Phase:...

  17. Western Area Power Administration Borrowing Authority, Recovery...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Western Area Power Administration Borrowing Authority, Recovery Act Western Area Power Administration Borrowing Authority, Recovery Act PDF icon Microsoft Word - PSRP May 15 2009 ...

  18. Contamination source review for Building E3180, Edgewood Area, Aberdeen Proving Ground, Maryland

    SciTech Connect (OSTI)

    Zellmer, S.D.; Smits, M.P.; Rueda, J.; Zimmerman, R.E.

    1995-09-01

    This report was prepared by Argonne National Laboratory (ANL) to document the results of a contamination source review of Building E3180 at the Aberdeen Proving Ground (APG) in Maryland. The report may be used to assist the US Army in planning for the future use or disposition of this building. The review included a historical records search, physical inspection, photographic documentation, geophysical investigation, collection of air samples, and review of available records regarding underground storage tanks associated with Building E3180. The field investigations were performed by ANL during 1994. Building,E3180 (current APG designation) is located near the eastern end of Kings Creek Road, north of Kings Creek, and about 0.5 miles east of the airstrip within APG`s Edgewood Area. The building was constructed in 1944 as a facsimile of a Japanese pillbox and used for the development of flame weapons systems until 1957 (EAI Corporation 1989). The building was not used from 1957 until 1965, when it was converted and used as a flame and incendiary laboratory. During the 1970s, the building was converted to a machine (metal) shop and used for that purpose until 1988.

  19. DOE feasibility report on Lake Calumet area refuse-to-energy facility

    SciTech Connect (OSTI)

    1980-06-18

    Site analyses and literature reviews were conducted to determine the feasibility of building an energy-producing municipal waste incinerator at Calumet Lake, Illinois. The amount of burnable waste produced within 5 and 10 miles of the near-Chicago site, the composition and heating value of this solid waste, and the air pollution impacts of waste incineration were determined, and the economic value of recovered material or of steam and electricity produced at the plant are discussed. It is concluded that there is sufficient refuse in the area to support a refuse processing center, that increasng landfill costs make such a center economically attractive, and that the Btu content of the refuse is adequate to produce steam for heat and power use. Replacing existing oil-fired power plants with this facility would result in an 88% reduction in current pollutant emission levels. There is a ready market for steam that could be produced. It is recommended that steps be taken to implement the establishment of the proposed waste processing center. (LCL)

  20. Wide area continuous offender monitoring

    SciTech Connect (OSTI)

    Hoshen, J.; Drake, G.; Spencer, D.

    1996-11-01

    The corrections system in the U.S. is supervising over five million offenders. This number is rising fast and so are the direct and indirect costs to society. To improve supervision and reduce the cost of parole and probation, first generation home arrest systems were introduced in 1987. While these systems proved to be helpful to the corrections system, their scope is rather limited because they only cover an offender at a single location and provide only a partial time coverage. To correct the limitations of first-generation systems, second-generation wide area continuous electronic offender monitoring systems, designed to monitor the offender at all times and locations, are now on the drawing board. These systems use radio frequency location technology to track the position of offenders. The challenge for this technology is the development of reliable personal locator devices that are small, lightweight, with long operational battery life, and indoors/outdoors accuracy of 100 meters or less. At the center of a second-generation system is a database that specifies the offender`s home, workplace, commute, and time the offender should be found in each. The database could also define areas from which the offender is excluded. To test compliance, the system would compare the observed coordinates of the offender with the stored location for a given time interval. Database logfiles will also enable law enforcement to determine if a monitored offender was present at a crime scene and thus include or exclude the offender as a potential suspect.

  1. 300 Area signal cable study

    SciTech Connect (OSTI)

    Whattam, J.W.

    1994-09-15

    This report was prepared to discuss the alternatives available for removing the 300 Area overhead signal cable system. This system, installed in 1969, has been used for various monitoring and communication signaling needs throughout the 300 Area. Over the years this cabling system has deteriorated, has been continually reconfigured, and has been poorly documented to the point of nonreliability. The first step was to look at the systems utilizing the overhead signal cable that are still required for operation. Of the ten systems that once operated via the signal cable, only five are still required; the civil defense evacuation alarms, the public address (PA) system, the criticality alarms, the Pacific Northwest Laboratory Facilities Management Control System (FMCS), and the 384 annunciator panel. Of these five, the criticality alarms and the FMCS have been dealt with under other proposals. Therefore, this study focused on the alternatives available for the remaining three systems (evacuation alarms, PA system, and 384 panel) plus the accountability aid phones. Once the systems to be discussed were determined, then three alternatives for providing the signaling pathway were examined for each system: (1) re-wire using underground communication ducts, (2) use the Integrated Voice/Data Telecommunications System (IVDTS) already installed and operated by US West, and (3) use radio control. Each alternative was developed with an estimated cost, advantages, and disadvantages. Finally, a recommendation was provided for the best alternative for each system.

  2. EA-1050: Test Area North Pool Stabilization Project, Idaho Falls, Idaho

    Broader source: Energy.gov [DOE]

    This EA evaluates the environmental impacts of the U.S. Department of Energy's Idaho National Engineering Laboratory's proposal to remove 344 canisters of Three Mile Island core debris and...

  3. Observation of Electron Neutrino Appearance in the NuMI Beam with the NOvA Experiment

    SciTech Connect (OSTI)

    Niner, Evan David

    2015-01-01

    NOvA is a long-baseline neutrino oscillation experiment that uses two functionally identical detectors separated by 810 kilometers at locations 14 milliradians off-axis from the NuMI muon neutrino beam at Fermilab. At these locations the beam energy peaks at 2 GeV. This baseline is the longest in the world for an accelerator-based neutrino oscillation experiment, which enhances the sensitivity to the neutrino mass ordering. The experiment studies oscillations of the muon neutrino and anti-neutrino beam that is produced. Both detectors completed commissioning in the summer of 2014 and continue to collect data. One of the primary physics goals of the experiment is the measurement of electron neutrino appearance in the muon neutrino beam which yields measurements of the oscillation parameters sin213, δ , and the neutrino mass ordering within the standard model of neutrino oscillations. This thesis presents the analysis of data collected between February 2014 and May 2015, corresponding to 3.52 X 1020 protons-on-target. In this first analysis NOvA recorded 6 electron neutrino candidates, which is a 3.3σ observation of electron neutrino appearance. The T2K experiment performs the same measurement on a baseline of 295 kilometers and has a 1 σ preference for the normal mass ordering over the inverted ordering over the phase space of the CP violating parameter δ, which is also weakly seen in the NOvA result. By the summer of 2016 NOvA will triple its statistics due to increased beam power and a completed detector. If electron neutrinos continue to be observed at the current rate NOvA will be able to establish a mass ordering preference at a similar confidence level to T2K.

  4. Sealed head access area enclosure

    DOE Patents [OSTI]

    Golden, Martin P.; Govi, Aldo R.

    1978-01-01

    A liquid-metal-cooled fast breeder power reactor is provided with a sealed head access area enclosure disposed above the reactor vessel head consisting of a plurality of prefabricated structural panels including a center panel removably sealed into position with inflatable seals, and outer panels sealed into position with semipermanent sealant joints. The sealant joints are located in the joint between the edge of the panels and the reactor containment structure and include from bottom to top an inverted U-shaped strip, a lower layer of a room temperature vulcanizing material, a separator strip defining a test space therewithin, and an upper layer of a room temperature vulcanizing material. The test space is tapped by a normally plugged passage extending to the top of the enclosure for testing the seal or introducing a buffer gas thereinto.

  5. Geothermal resource evaluation of the Yuma area

    SciTech Connect (OSTI)

    Poluianov, E.W.; Mancini, F.P.

    1985-11-29

    This report presents an evaluation of the geothermal potential of the Yuma, Arizona area. A description of the study area and the Salton Trough area is followed by a geothermal analysis of the area, a discussion of the economics of geothermal exploration and exploitation, and recommendations for further testing. It was concluded economic considerations do not favor geothermal development at this time. (ACR)

  6. Biomass Program 2007 Accomplishments - Infrastructure Technology Area

    SciTech Connect (OSTI)

    Glickman, Joan

    2007-09-01

    This document details the accomplishments of the Biomass Program Infrastructure Technoloy Area in 2007.

  7. Outdoor Area Lighting | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Outdoor Area Lighting Outdoor Area Lighting This document reviews the major design and specification concerns for outdoor area lighting, and discusses the potential for LED luminaires to save energy plant-wide while providing high quality lighting for outdoor areas. Outdoor Area Lighting (June 2008) (3.16 MB) More Documents & Publications Philadelphia International Airport Apron Lighting: LED System Performance in a Trial Installation Model Specification for LED Roadway Luminaires, V2.0

  8. Environmental analysis of geopressured-geothermal prospect areas, De Witt and Colorado counties, Texas. Final report, March 1 - August 31, 1979

    SciTech Connect (OSTI)

    Gustavson, T.C.; Reeder, F.S.; Badger, E.A.

    1980-02-01

    Information collected and analyzed for a preliminary environmental analysis of geopressured geothermal prospect areas in Colorado and DeWitt Counties, Texas is presented. Specific environmental concerns for each geopressured geothermal prospect area are identified and discussed. Approximately 218 km/sup 2/(85 mi/sup 2/) were studied in the vicinity of each prospect area to: (1) conduct an environmental analysis to identify more and less suited areas for geopressured test wells; and (2) provide an environmental data base for future development of geopressured geothermal energy resources. A series of maps and tables are included to illustrate environmental characteristics including: geology, water resources, soils, current land use, vegetation, wildlife, and meteorological characteristics, and additional relevant information on cultural resources, power- and pipelines, and regulatory agencies. A series of transparent overlays at the scale of the original mapping has also been produced for the purposes of identifying and ranking areas of potential conflict between geopressured geothermal development and environmental characteristics. The methodology for ranking suitability of areas within the two prospect areas is discussed in the appendix. (MHR)

  9. Arsenite evokes IL-6 secretion, autocrine regulation of STAT3 signaling, and miR-21 expression, processes involved in the EMT and malignant transformation of human bronchial epithelial cells

    SciTech Connect (OSTI)

    Luo, Fei; Xu, Yuan; Ling, Min; Zhao, Yue; Xu, Wenchao; Liang, Xiao; Jiang, Rongrong; Wang, Bairu; Bian, Qian; Liu, Qizhan

    2013-11-15

    Arsenite is an established human carcinogen, and arsenite-induced inflammation contributes to malignant transformation of cells, but the molecular mechanisms by which cancers are produced remain to be established. The present results showed that, evoked by arsenite, secretion of interleukin-6 (IL-6), a pro-inflammatory cytokine, led to the activation of STAT3, a transcription activator, and to increased levels of a microRNA, miR-21. Blocking IL-6 with anti-IL-6 antibody and inhibiting STAT3 activation reduced miR-21 expression. For human bronchial epithelial cells, cultured in the presence of anti-IL-6 antibody for 3 days, the arsenite-induced EMT and malignant transformation were reversed. Thus, IL-6, acting on STAT3 signaling, which up-regulates miR-21in an autocrine manner, contributes to the EMT induced by arsenite. These data define a link from inflammation to EMT in the arsenite-induced malignant transformation of HBE cells. This link, mediated through miRNAs, establishes a mechanism for arsenite-induced lung carcinogenesis. - Highlights: Arsenite evokes IL-6 secretion. IL-6 autocrine mediates STAT3 signaling and up-regulates miR-21expression. Inflammation is involved in arsenite-induced EMT.

  10. Corrective Action Plan for Corrective Action Unit 417: Central Nevada Test Area Surface, Nevada

    SciTech Connect (OSTI)

    K. Campbell

    2000-04-01

    This Corrective Action Plan provides methods for implementing the approved corrective action alternative as provided in the Corrective Action Decision Document for the Central Nevada Test Area (CNTA), Corrective Action Unit (CAU) 417 (DOE/NV, 1999). The CNTA is located in the Hot Creek Valley in Nye County, Nevada, approximately 137 kilometers (85 miles) northeast of Tonopah, Nevada. The CNTA consists of three separate land withdrawal areas commonly referred to as UC-1, UC-3, and UC-4, all of which are accessible to the public. CAU 417 consists of 34 Corrective Action Sites (CASs). Results of the investigation activities completed in 1998 are presented in Appendix D of the Corrective Action Decision Document (DOE/NV, 1999). According to the results, the only Constituent of Concern at the CNTA is total petroleum hydrocarbons (TPH). Of the 34 CASs, corrective action was proposed for 16 sites in 13 CASs. In fiscal year 1999, a Phase I Work Plan was prepared for the construction of a cover on the UC-4 Mud Pit C to gather information on cover constructibility and to perform site management activities. With Nevada Division of Environmental Protection concurrence, the Phase I field activities began in August 1999. A multi-layered cover using a Geosynthetic Clay Liner as an infiltration barrier was constructed over the UC-4 Mud Pit. Some TPH impacted material was relocated, concrete monuments were installed at nine sites, signs warning of site conditions were posted at seven sites, and subsidence markers were installed on the UC-4 Mud Pit C cover. Results from the field activities indicated that the UC-4 Mud Pit C cover design was constructable and could be used at the UC-1 Central Mud Pit (CMP). However, because of the size of the UC-1 CMP this design would be extremely costly. An alternative cover design, a vegetated cover, is proposed for the UC-1 CMP.

  11. Closure Report for Corrective Action Unit 151: Septic Systems and Discharge Area, Nevada Test Site, Nevada

    SciTech Connect (OSTI)

    NSTec Environmental Restoration

    2008-04-01

    Corrective Action Unit (CAU) 151 is identified in the Federal Facility Agreement and Consent Order (FFACO) as Septic Systems and Discharge Area. CAU 151 consists of the following eight Corrective Action Sites (CASs), located in Areas 2, 12, and 18 of the Nevada Test Site, approximately 65 miles northwest of Las Vegas, Nevada: (1) CAS 02-05-01, UE-2ce Pond; (2) CAS 12-03-01, Sewage Lagoons (6); (3) CAS 12-04-01, Septic Tanks; (4) CAS 12-04-02, Septic Tanks; (5) CAS 12-04-03, Septic Tank; (6) CAS 12-47-01, Wastewater Pond; (7) CAS 18-03-01, Sewage Lagoon; and (8) CAS 18-99-09, Sewer Line (Exposed). CAU 151 closure activities were conducted according to the FFACO (FFACO, 1996; as amended February 2008) and the Corrective Action Plan for CAU 151 (U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office, 2007) from October 2007 to January 2008. The corrective action alternatives included no further action, clean closure, and closure in place with administrative controls. CAU 151 closure activities are summarized in Table 1. Closure activities generated liquid remediation waste, sanitary waste, hydrocarbon waste, and mixed waste. Waste generated was appropriately managed and disposed. Waste that is currently staged onsite is being appropriately managed and will be disposed under approved waste profiles in permitted landfills. Waste minimization activities included waste characterization sampling and segregation of waste streams. Some waste exceeded land disposal restriction limits and required offsite treatment prior to disposal. Other waste meeting land disposal restrictions was disposed of in appropriate onsite or offsite landfills. Waste disposition documentation is included as Appendix C.

  12. Corrective Action Investigation Plan for Corrective Action Unit 374: Area 20 Schooner Unit Crater Nevada Test Site, Nevada, Revision 0

    SciTech Connect (OSTI)

    Patrick Matthews

    2010-02-01

    Corrective Action Unit 374 is located in Areas 18 and 20 of the Nevada Test Site, which is approximately 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 374 comprises the five corrective action sites (CASs) listed below: • 18-22-05, Drum • 18-22-06, Drums (20) • 18-22-08, Drum • 18-23-01, Danny Boy Contamination Area • 20-45-03, U-20u Crater (Schooner) These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). Additional information will be obtained by conducting a corrective action investigation before evaluating CAAs and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable CAAs that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on October 20, 2009, by representatives of the Nevada Division of Environmental Protection and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 374.

  13. Closure Report for Corrective Action Unit 262: Area 25 Septic Systems and Underground Discharge Point, Nevada Test Site, Nevada

    SciTech Connect (OSTI)

    D. S. Tobiason

    2003-07-01

    This Closure Report (CR) documents the activities undertaken to close Corrective Action Unit (CAU) 262: Area 25 Septic Systems and Underground Discharge Point, in accordance with the Federal Facility Agreement and Consent Order (FFACO) of 1996. Site closure was performed in accordance with the Nevada Division of Environmental Protection (NDEP)-approved Corrective Action Plan (CAP) for CAU 262 (U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office [NNSA/NV, 2002a]). CAU 262 is located at the Nevada Test Site (NTS) approximately 105 kilometers (65 miles) northwest of Las Vegas, Nevada. CAU 262 consists of the following nine Corrective Action Sites (CASs) located in Area 25 of the NTS: CAS 25-02-06, Underground Storage tank CAS 25-04-06, Septic Systems A and B CAS 25-04-07, Septic System CAS 25-05-03, Leachfield CAS 25-05-05, Leachfield CAS 25-05-06, Leachfield CAS 25-05-08, Radioactive Leachfield CAS 25-05-12, Leachfield CAS 25-51-01, Dry Well.

  14. Differential cross sections for the reactions <mimi><mi>pmi><mi>pη> and <mimi><mi>pmi><mi>pmi><mi>η>'

    SciTech Connect (OSTI)

    Williams, M.; Krahn, Z.; Applegate, D.; Bellis, M.; Meyer, C. A.; Adhikari, K. P.; Anghinolfi, M.; Baghdasaryan, H.; Ball, J.; Battaglieri, M.; Bedlinskiy, I.; Berman, B. L.; Biselli, A. S.; Bookwalter, C.; Briscoe, W. J.; Brooks, W. K.; Burkert, V. D.; Careccia, S. L.; Carman, D. S.; Cole, P. L.; Collins, P.; Crede, V.; D’Angelo, A.; Daniel, A.; Vita, R. De; Sanctis, E. De; Deur, A.; Dey, B.; Dhamija, S.; Dickson, R.; Djalali, C.; Dodge, G. E.; Doughty, D.; Dugger, M.; Dupre, R.; Alaoui, A. El; Elouadrhiri, L.; Eugenio, P.; Fegan, S.; Fradi, A.; Gabrielyan, M. Y.; Garçon, M.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Gohn, W.; Golovatch, E.; Gothe, R. W.; Griffioen, K. A.; Guidal, M.; Guler, N.; Guo, L.; Hafidi, K.; Hakobyan, H.; Hanretty, C.; Hassall, N.; Hicks, K.; Holtrop, M.; Ilieva, Y.; Ireland, D. G.; Ishkhanov, B. S.; Isupov, E. L.; Jawalkar, S. S.; Jo, H. S.; Johnstone, J. R.; Joo, K.; Keller, D.; Khandaker, M.; Khetarpal, P.; Kim, W.; Klein, A.; Klein, F. J.; Kubarovsky, V.; Kuleshov, S. V.; Kuznetsov, V.; Livingston, K.; Lu, H. Y.; Mayer, M.; McAndrew, J.; McCracken, M. E.; McKinnon, B.; Mikhailov, K.; Mineeva, T.; Mirazita, M.; Mokeev, V.; Moriya, K.; Morrison, B.; Munevar, E.; Nadel-Turonski, P.; Nepali, C. S.; Niccolai, S.; Niculescu, G.; Niculescu, I.; Niroula, M. R.; Niyazov, R. A.; Osipenko, M.; Ostrovidov, A. I.; Park, K.; Park, S.; Pasyuk, E.; Pereira, S. Anefalos; Perrin, Y.; Pieschacon, D.; Pisano, S.; Pogorelko, O.; Pozdniakov, S.; Price, J. W.; Procureur, S.; Prok, Y.; Protopopescu, D.; Raue, B. A.; Ricco, G.; Ripani, M.; Ritchie, B. G.; Rosner, G.; Rossi, P.; Sabatié, F.; Saini, M. S.; Salamanca, J.; Salgado, C.; Schott, D.; Schumacher, R. A.; Seraydaryan, H.; Sharabian, Y. G.; Smith, E. S.; Sober, D. I.; Sokhan, D.; Stepanyan, S. S.; Stoler, P.; Strakovsky, I. I.; Strauch, S.; Taiuti, M.; Tedeschi, D. J.; Tkachenko, S.; Ungaro, M.; Vineyard, M. F.; Voutier, E.; Watts, D. P.; Weinstein, L. B.; Weygand, D. P.; Wood, M. H.; Zhang, J.; Zhao, B.

    2009-10-29

    In high-statistics differential cross sections for the reactions γ p -> p η and γ p -> p η' the CLAS at Jefferson Lab was used to measure the center-of-mass energies from near threshold up to 2.84 GeV. The eta-prime results are the most precise to date and provide the largest energy and angular coverage. The eta measurements extend the energy range of the world's large-angle results by approximately 300 MeV. These new data, in particular the η' measurements, are likely to help constrain the analyses being performed to search for new baryon resonance states.

  15. Categorical Exclusion Determinations: Western Area Power Administration |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Administration Categorical Exclusion Determinations: Western Area Power Administration Categorical Exclusion Determinations issued by Western Area Power Administration. DOCUMENTS AVAILABLE FOR DOWNLOAD No downloads found for this office.

  16. West Flank Cosa, CA FORGE Test Area

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Doug Blankenship

    2015-11-15

    A map with the Coso West Flank FORGE test area outlined, along with regional seismicity, the aeromagnetic data set and the area currently being utilized for the creation of the 3D model.

  17. Magnetotellurics At Truckhaven Area (Layman Energy Associates...

    Open Energy Info (EERE)

    9. The 95 magnetotelluric (MT) soundings cover a central area of about 80 square kilometers. The 126 gravity stations extend over a broader area of about 150 square kilometers,...

  18. WASTE AREA GROUP 7 PROPOSED PLAN

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AREA GROUP 7 PROPOSED PLAN The Idaho National Laboratory (INL) Citizens Advisory Board (CAB) has provided its input to the Department of Energy on the Waste Area Group 7 (WAG 7)...

  19. LED Outdoor Area Lighting Fact Sheet

    SciTech Connect (OSTI)

    2008-06-01

    This fact sheet reviews the major design and specification concerns for outdoor area lighting, and discusses the potential for LED luminaires to save energy while providing high quality lighting for outdoor areas.

  20. Transfer Area Mechanical Handling Calculation

    SciTech Connect (OSTI)

    B. Dianda

    2004-06-23

    This calculation is intended to support the License Application (LA) submittal of December 2004, in accordance with the directive given by DOE correspondence received on the 27th of January 2004 entitled: ''Authorization for Bechtel SAX Company L.L. C. to Include a Bare Fuel Handling Facility and Increased Aging Capacity in the License Application, Contract Number DE-AC28-01R W12101'' (Arthur, W.J., I11 2004). This correspondence was appended by further Correspondence received on the 19th of February 2004 entitled: ''Technical Direction to Bechtel SAIC Company L.L. C. for Surface Facility Improvements, Contract Number DE-AC28-OIRW12101; TDL No. 04-024'' (BSC 2004a). These documents give the authorization for a Fuel Handling Facility to be included in the baseline. The purpose of this calculation is to establish preliminary bounding equipment envelopes and weights for the Fuel Handling Facility (FHF) transfer areas equipment. This calculation provides preliminary information only to support development of facility layouts and preliminary load calculations. The limitations of this preliminary calculation lie within the assumptions of section 5 , as this calculation is part of an evolutionary design process. It is intended that this calculation is superseded as the design advances to reflect information necessary to support License Application. The design choices outlined within this calculation represent a demonstration of feasibility and may or may not be included in the completed design. This calculation provides preliminary weight, dimensional envelope, and equipment position in building for the purposes of defining interface variables. This calculation identifies and sizes major equipment and assemblies that dictate overall equipment dimensions and facility interfaces. Sizing of components is based on the selection of commercially available products, where applicable. This is not a specific recommendation for the future use of these components or their related

  1. Sandia National Laboratories: About Sandia: Mission Areas

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mission Areas Mission Statements The Laboratory Leadership Team decided on a set of integrated Mission Areas that best reflect Sandia's mission based on three key characteristics: synergy with nuclear weapons capabilities, national security impact, and strategic value needed to ensure Sandia's enduring contribution to the nation. The Mission Areas bring focus to the work we conduct in national security. The middle tier Mission Areas are strongly interdependent with and essential to the nuclear

  2. Research Areas | National Nuclear Security Administration | (NNSA)

    National Nuclear Security Administration (NNSA)

    Research Areas High Energy Density Laboratory Plasmas (HEDLP) Research Areas During open solicitations proposals are sought in the following subfields and cross-cutting areas of HEDLP: High Energy Density Hydrodynamics Specific areas of interest include, but are not limited to, turbulent mixing, probing properties of high energy density (HED) matter through hydrodynamics, solid-state hydrodynamics at high pressures, new hydrodynamic instabilities, and hydrodynamic scaling. Radiation-Dominated

  3. Bay Area | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    Bay Area San Francisco Bay Area Aerial Radiation Assessment Survey (SAN JOSE and SAN FRANCISCO, California) - A helicopter may be seen flying at low altitudes over portions of the San Francisco Bay Area from January 29 through February 6, 2016. The purpose of the flyovers is to measure naturally occurring background radiation. Officials from the National Nuclear... NNSA to Conduct Aerial Radiological Surveys Over San Francisco, Pacifica, Berkeley, And Oakland, CA Areas A U.S. Department of

  4. Focus Areas 1 and 4 Deliverables

    Office of Environmental Management (EM)

    1 - Requirements Flow Down and Focus Area #4 - Graded Approach to Quality Assurance Graded Approach Model and Expectation Page 1 of 18 Office of Environmental Management And Energy Facility Contractors Group Quality Assurance Improvement Project Plan Project Focus Area Task # and Description Deliverable Project Area 1: Requirements Flow Down Task #1.9 - Complete White Paper covering procurement QA process flow diagram Draft White Paper and Amended Flow Diagram Project Area 4: Graded Approach

  5. Water Sampling At International Geothermal Area, Philippines...

    Open Energy Info (EERE)

    Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Water Sampling At International Geothermal Area, Philippines (Wood, 2002) Exploration...

  6. Functional Area Qualification Standard Reference Guides

    Broader source: Energy.gov [DOE]

    The reference guides have been developed to address the competency statements in DOE Functional Area Qualification Standard.

  7. Geothermal Literature Review At International Geothermal Area...

    Open Energy Info (EERE)

    navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Geothermal Literature Review At International Geothermal Area, Iceland (Ranalli & Rybach, 2005)...

  8. Geothermal Literature Review At International Geothermal Area...

    Open Energy Info (EERE)

    navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Geothermal Literature Review At International Geothermal Area, New Zealand (Ranalli & Rybach, 2005)...

  9. Geothermal Literature Review At International Geothermal Area...

    Open Energy Info (EERE)

    navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Geothermal Literature Review At International Geothermal Area, Italy (Ranalli & Rybach, 2005) Exploration...

  10. Geographic Information System At International Geothermal Area...

    Open Energy Info (EERE)

    search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Geographic Information System At International Geothermal Area, Indonesia (Nash, Et Al., 2002) Exploration Activity...

  11. D-Area Preliminary Hazards Analysis

    SciTech Connect (OSTI)

    Blanchard, A.; Paik, I.R.

    1998-04-01

    A comprehensive review of hazards associated with the D-Area was performed to identify postulated event scenarios.

  12. Fire Protection Engineering Functional Area Qualification Standard

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    FIRE PROTECTION ENGINEERING FUNCTIONAL AREA QUALIFICATION STANDARD DOE Defense Nuclear Facilities Technical ... by applied engineering fundamentals, research, fire hazard ...

  13. Considering LEDs for Street and Area Lighting

    Broader source: Energy.gov [DOE]

    View Jim Brodrick's keynote video from the September 2009 IES Street and Area Lighting Conference in Philadelphia.

  14. Navy 1 Geothermal Area | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Navy 1 Geothermal Area Navy 1 Geothermal Area The Navy 1 Geothermal Project is located on the test and evaluation ranges of the Naval Air Weapons Station, China Lake. At its peak, the project produced more than 273 megawatts of electricity that was sold into the local utility grid under a long-term power sales agreement. Photo of the Coso Geothermal Area

  15. The Geysers Geothermal Area | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    The Geysers Geothermal Area The Geysers Geothermal Area The Geysers Geothermal area, north of San Francisco, California, is the world's largest dry-steam geothermal steam field. Power production at the Geysers reached peak production in 1987, at that time serving 1.8 million people. Photo of The Geysers power plant

  16. Beryllium Facilities & Areas - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Facilities & Areas About Us Hanford Cultural Resources Beryllium Program Beryllium Program Points of Contact Beryllium Facilities & Areas Beryllium Program Information Hanford CBDPP Committee Beryllium FAQs Beryllium Related Links Hanford Beryllium Awareness Group (BAG) Program Performance Assessments Beryllium Program Feedback Beryllium Health Advocates Primary Contractors/Employers Medical Testing and Surveillance Facilities General Resources Beryllium Facilities & Areas Email

  17. Casa Diablo Geothermal Area | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Casa Diablo Geothermal Area Casa Diablo Geothermal Area The Mammoth-Pacific geothermal power plants at Casa Diablo on the eastern front of the Sierra Nevada Range generate enough power for approximately 40,000 homes. The power is sold to Southern California Edison under long-term contracts. Photo of the Casa Diablo Geothermal area.

  18. An Aerial Radiological survey of the Alvin W. Vogtle Nuclear Plant and surrounding area, Waynesboro, Georgia: Date of survey: August--September 1988

    SciTech Connect (OSTI)

    Not Available

    1990-09-01

    An Aerial Radiological Survey was conducted during the period of August 24 to September 14, 1988 over an area of approximately 310 square kilometers (120 square miles) surrounding the Alvin W. Vogtle Nuclear Plant. The Vogtle Nuclear Plant is located near Augusta, Georgia, along the Savannah River and adjacent to the Savannah River Site (SRS). Several anomalous areas were identified in the portion of the survey extending into the SRS perimeter. The dominant isotopes found in these areas were cesium-137 and cobalt-60. All of these man-made anomalies identified by the aerial measurements were attributed to SRS processing. For the remainder of the survey area, the inferred radiation exposure rates generally varied from 6 to 10 microroentgens per hour ({mu}R/h), which was found to be due to naturally occurring uranium, thorium, and radioactive potassium gamma emitters. The reported exposure rate values included an estimated cosmic ray contribution of 3.6 {mu}R/h. Soils samples and pressurized ion chamber measurements were obtained at three locations within the survey boundaries to support the aerial data. The exposure rate values obtained from these groundbased measurements were in agreement with the corresponding inferred aerial values. 6 refs., 13 figs., 4 tabs.

  19. Ecloud Build-Up Simulations for the FNAL MI for a Mixed Fill Pattern: Dependence on Peak SEY and Pulse Intensity During the Ramp

    SciTech Connect (OSTI)

    Furman, M. A.

    2010-12-11

    We present simulation results of the build-up of the electron-cloud density n{sub e} in three regions of the FNAL Main Injector (MI) for a beam fill pattern made up of 5 double booster batches followed by a 6th single batch. We vary the pulse intensity in the range N{sub t} = (2-5) x 10{sup 13}, and the beam kinetic energy in the range E{sub k} = 8-120 GeV. We assume a secondary electron emission model qualitatively corresponding to TiN, except that we let the peak value of the secondary electron yield (SEY) {delta}{sub max} vary as a free parameter in a fairly broad range. Our main conclusions are: (1) At fixed N{sub t} there is a clear threshold behavior of n{sub e} as a function of {delta}{sub max} in the range {approx} 1.1-1.3. (2) At fixed {delta}{sub max}, there is a threshold behavior of n{sub e} as a function of N{sub t} provided {delta}{sub max} is sufficiently high; the threshold value of N{sub t} is a function of the characteristics of the region being simulated. (3) The dependence on E{sub k} is weak except possibly at transition energy. Most of these results were informally presented to the relevant MI personnel in April 2010.

  20. The Office of Minority Economic Impact (MI) was established in Fiscal Year 1979 pursuant to Section 641 Title V1, Part 3 of the National Energy Conservation Policy Act (Public Law 95-619), dated November 9, 1978

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Minority Economic Impact (MI) was established in Fiscal Year 1979 pursuant to Section 641 Title V1, Part 3 of the National Energy Conservation Policy Act (Public Law 95- 619), dated November 9, 1978. The following is MI's legislative mandate. PART 3 - - MINORITY ECONOMIC IMPACT SEC. 641. MINORITY ECONOMIC IMPACT. "(a) Establishment of Office of Minority Economic Impact -- Title II of the Department of Energy Organization Act (42 U.S.C. 7131 - - 7139) is amended by adding at the end thereof

  1. Technical Area (TA)-54 Area G Nitrate-Salt Waste Container Response...

    Broader source: Energy.gov (indexed) [DOE]

    Pilot Plant on February 14, 2014, report in Attachment F. Bibliography and References, are available on various public websites. Technical Area (TA)-54 Area G Nitrate-Salt ...

  2. 2016 DOE Project Management Workshop - Area Restaurants | Department...

    Office of Environmental Management (EM)

    Area Restaurants 2016 DOE Project Management Workshop - Area Restaurants Information on surrounding area restaurants PDF icon Area restaurants Key Resources PMCDP EVMS PARS IIe FPD ...

  3. Proposed plan for remedial action for the Groundwater Operable Unit at the Chemical Plant Area of the Weldon Spring Site, Weldon Spring, Missouri

    SciTech Connect (OSTI)

    1999-08-10

    This Proposed Plan addresses the remediation of groundwater contamination at the chemical plant area of the Weldon Spring site in Weldon Spring, Missouri. The site is located approximately 48 km (30 mi) west of St. Louis in St. Charles County . Remedial activities at the site will be conducted in accordance with the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). The U.S. Department of Energy (DOE), in conjunction with the U.S. Department of the Army (DA), conducted a joint remedial investigation/feasibility study (RI/FS) to allow for a comprehensive evaluation of groundwater conditions at the Weldon Spring chemical plant area and the Weldon Spring ordnance works area, which is an Army site adjacent to the chemical plant area. Consistent with DOE policy, National Environmental Policy Act (NEPA) values have been incorporated into the CERCLA process. That is, the analysis conducted and presented in the RVFS reports included an evaluation of environmental impacts that is comparable to that performed under NEPA. This Proposed Plan summarizes information about chemical plant area groundwater that is presented in the following documents: (1) The Remedial Investigation (RI), which presents information on the nature and extent of contamination; (2) The Baseline Risk Assessment (BRA), which evaluates impacts to human health and the environment that could occur if no cleanup action of the groundwater were taken (DOE and DA 1997a); and (3) The Feasibility Study (FS) and the Supplemental FS, which develop and evaluate remedial action alternatives for groundwater remediation.

  4. Research Subject Areas for CSES Proposals

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research Subject Areas Research Subject Areas for CSES Proposals High quality, cutting-edge science in the areas of astrophysics, space physics, solid planetary geoscience, and climate science. Contact Director Reiner Friedel (505) 665-1936 Email Professional Staff Assistant Georgia D. Sanchez (505) 665-0855 Email Science Discipline Leaders Astrophysics & Cosmology Hui Li (505) 665-3131 Email Climate Keeley Costigan (505) 665-4788 Email Geophysics David Coblentz (505) 667-2781 Email Space

  5. 2010sr29[M Area].doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Wednesday, October 20, 2010 Paivi Nettamo, SRNS, (803) 952-6938 Savannah River Site Marks Recovery Act Cleanup Milestone M Area cleanup work was finished nearly two years ahead of schedule AIKEN, S.C. (October 20) - Department of Energy, contractor and regulatory representatives gathered today to celebrate the completion of cleanup work at Savannah River Site's M Area, nearly two years ahead of schedule. This area cleanup was the first at SRS to be completed with the help of American Recovery

  6. Pengalengan Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Geothermal Area Profile Location: Bandung Regency, Indonesia Exploration Region: West Java GEA Development Phase: Operational"Operational" is not in the list of possible values...

  7. Tank Farm Area Cleanup Decision-Making

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Area Cleanup Decision-Making Groundwater Vadose Zone Single Shell Tank System Closure (tanks, structures and pipelines) * Washington State Hazardous Waste Management Act (Resource...

  8. NSTB Summarizes Vulnerable Areas | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    NSTB Summarizes Vulnerable Areas Experts at the National SCADA Test Bed (NSTB) discovered ... Lessons Learned from Cyber Security Assessments of SCADA and Energy Management Systems ...

  9. Alaska Special Area Regulations | Open Energy Information

    Open Energy Info (EERE)

    to library Web Site: Alaska Special Area Regulations Author Alaska Department of Fish & Game Published Publisher Not Provided, 2014 DOI Not Provided Check for DOI...

  10. Berkshire East Ski Area | Open Energy Information

    Open Energy Info (EERE)

    Energy Development Energy Purchaser Berkshire East Ski Area Location Charlemont MA Coordinates 42.61621237, -72.86660671 Show Map Loading map... "minzoom":false,"mapp...

  11. Redfield Campus Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Overview Geothermal Area Profile Location: Nevada Exploration Region: Walker-Lane Transition Zone Geothermal Region GEA Development Phase: Resource Estimate Mean Reservoir Temp:...

  12. Hawthorne Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Overview Geothermal Area Profile Location: Nevada Exploration Region: Walker-Lane Transition Zone Geothermal Region GEA Development Phase: Coordinates: 38.53, -118.65...

  13. Wendel Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Geothermal Area Profile Location: California Exploration Region: Walker-Lane Transition Zone Geothermal Region GEA Development Phase: Operational"Operational" is not in the...

  14. Rhodes Marsh Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Overview Geothermal Area Profile Location: Nevada Exploration Region: Walker-Lane Transition Zone Geothermal Region GEA Development Phase: Resource Estimate Mean Reservoir Temp:...

  15. Research Areas | National Nuclear Security Administration | ...

    National Nuclear Security Administration (NNSA)

    ... of traditional ideal-plasma theory and standard condensed matter theory do not apply. ... This includes investigations in related areas of plasma physics, inertial fusion, atomic ...

  16. Takigami Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Overview 2 History and Infrastructure 3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid Geochemistry 8...

  17. Yamagawa Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Overview 2 History and Infrastructure 3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid Geochemistry 8...

  18. New River Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid Geochemistry 8 NEPA-Related Analyses (0) 9 Exploration...

  19. East Brawley Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid Geochemistry 8 NEPA-Related Analyses (0) 9 Exploration...

  20. Clear Lake Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid Geochemistry 8 NEPA-Related Analyses (0) 9 Exploration...

  1. South Brawley Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid Geochemistry 8 NEPA-Related Analyses (0) 9 Exploration...

  2. Fort Bidwell Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid Geochemistry 8 NEPA-Related Analyses (0) 9 Exploration...

  3. Trial Demonstration of Area Lighting Retrofit

    Energy Savers [EERE]

    Trial Demonstration of Area Lighting Retrofit Host Site: Yuma Border Patrol, Yuma, Arizona December 2014 Prepared for: Solid-State Lighting Program Building Technologies Office ...

  4. Geothermometry At Blackfoot Reservoir Area (Hutsinpiller & Parry...

    Open Energy Info (EERE)

    Activity Details Location Blackfoot Reservoir Area Exploration Technique Geothermometry Activity Date Usefulness useful DOE-funding Unknown References Amy Hutsinpiller, W. T....

  5. Maibarara Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Inc.. updated 20140209;cited 20150422. Available from: http:maibarara.com.ph List of existing Geothermal Resource Areas. Print PDF Retrieved from "http:...

  6. Honey Lake Geothermal Area | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    The Honey Lake geothermal area is located in Lassen County, California and Washoe County, Nevada. There are three geothermal projects actively producing electrical power. They are ...

  7. Lightning Dock Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Review At Lightning Dock Geothermal Area (Rafferty, 1997) Geothermal Literature Review Fossil Fuel-fired Peak Heating for Geothermal Greenhouses Geothermal Literature Review At...

  8. Area Information | Y-12 National Security Complex

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Oak Ridge: Convention and Visitors Bureau Oak Ridge: Oak Ridger Oak Ridge: Secret City History Area Attractions: To Do and See Knoxville: Clarence Brown Theater Knoxville: Frank...

  9. Medicine Lake Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Page Technique Activity Start Date Activity End Date Reference Material Geothermal Literature Review At Medicine Lake Geothermal Area (1984) Geothermal Literature Review 1984...

  10. Adak Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid Geochemistry 8 NEPA-Related Analyses (0) 9 Exploration...

  11. Hellisheidi Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid Geochemistry 8 NEPA-Related Analyses (0) 9 Exploration...

  12. Maui Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid Geochemistry 8 NEPA-Related Analyses (0) 9 Exploration...

  13. Romania Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid Geochemistry 8 NEPA-Related Analyses (0) 9 Exploration...

  14. Ndunga Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid Geochemistry 8 NEPA-Related Analyses (0) 9 Exploration...

  15. Bjarnaflag Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid Geochemistry 8 NEPA-Related Analyses (0) 9 Exploration...

  16. Yangbajain Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid Geochemistry 8 NEPA-Related Analyses (0) 9 Exploration...

  17. RMOTC Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid Geochemistry 8 NEPA-Related Analyses (0) 9 Exploration...

  18. Langjiu Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid Geochemistry 8 NEPA-Related Analyses (0) 9 Exploration...

  19. Lahendong Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    World Geothermal Power Generation 2001-2005. Proceedings of World Geothermal Congress; Turkey: World Geothermal Congress. List of existing Geothermal Resource Areas. Print PDF...

  20. Mindanao Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    World Geothermal Power Generation 2001-2005. Proceedings of World Geothermal Congress; Turkey: World Geothermal Congress. List of existing Geothermal Resource Areas. Print PDF...