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1

E-Print Network 3.0 - abakaliki fold belt Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

, British Columbia, Canada V8W 3P6 ABSTRACT--Two enigmas concerning the Cape Fold Belt (CFB), part... , and by convergence and the development of a foreland-verging fold and...

2

Mass movement-induced fold-and-thrust belt structures in unconsolidated sediments in Lake Lucerne (Switzerland)  

E-Print Network [OSTI]

Mass movement-induced fold-and-thrust belt structures in unconsolidated sediments in Lake Lucerne-lying, unconsolidated sediment at the foot of subaqueous slopes. These deformation structures appear beneath wedges

Gilli, Adrian

3

Petroleum geochemistry of Texas and Oklahoma oils from the Marathon/Ouachita fold belt  

SciTech Connect (OSTI)

The Marathon uplift of west Texas and the Ouachita Mountains of Oklahoma and Arkansas comprise the surface expressions of a Paleozoic orogenic belt extending across the south-central United States. A century of petroleum exploration in the Marathon and Ouachita exposures has yielded several oil discoveries. In this study, detailed molecular, elemental, and isotopic data are presented for nine Texas oils, five Oklahoma oils, and four Oklahoma solid bitumens, all associated with thrust belt rocks of the Marathons and Ouachitas. Oil-oil and oil-solid bitumen correlations are proposed, and the character of the organic matter in the source rock(s) is deduced from the chemistry of the oils and solid bitumens. All 18 samples are sourced from the same (or very similar) organic matter. This indicates that they are probably cogenetic, despite geographic separations of hundreds of miles. Chemical differences in these samples derive from secondary effects, including biodegradation (e.g., solid bitumens) and differing levels of thermal maturity. The occurrence of unusual chemical compounds (certain bisnor- and trisnor-hopanes) in all samples probably indicates the presence of anaerobic bacteria in the depositional environment. Source deductions from oil chemistry suggest that an Ordovician unit is responsible for these oils and solid bitumens. This conclusion is consistent with previous literature suggesting an Upper Ordovician source for Oklahoma Ouachita oils and supports tectonic reconstructions of the region during Ordovician time.

Curiale, J.A. (Unocal, Inc., Brea, CA (United States))

1991-03-01T23:59:59.000Z

4

Seismic data, geometry, evolution, and shortening in the active Sulaiman fold-and-thrust belt of Pakistan, southwest of the Himalayas  

SciTech Connect (OSTI)

Despite its long history of exploration, the Sulaiman fold and thrust belt is a poorly known structure and detailed structural and geochemical investigations are vital for the successful exploration, evaluation and exploitation of any hydrocarbons. Recent nappe and duplex structural models provide a framework for exploration. Surface and subsurface data from the Sulaiman fold-and-thrust belt are integrated to analyze the deep structure, tectonic, shortening, and kinematics of the Sulaiman fold-and-thrust belt at the western margin of the Indian subcontinent. Seismic reflection data show that nearly all the 10-km-thick sequence of dominantly platform (>7 km) and molasse strata is detached at the deformation front. The strata thicken tectonically to about 20 km in the hinterland without significant thrust faults in the foreland. A balanced structural cross-section suggests that structural uplift in the Sulaiman fold-and-thrust belt is a result of a thin-skinned, passive-roof duplex style of deformation. Sequential restoration of the balanced section reveals a series of structural and geometrical features including: (1) development of low-amplitude, broad concentric folds at the tip of the decollement; (2) increase in amplitude of a detachment fold to a critical level for development of ramp and duplex structures; and (3) out-of-sequence thrusting to create required critical taper for an outward translation of the foreland fold-and-thrust belt. A balanced structural cross-section 349 km long from the Sulaiman fold-and-thrust belt restores to an original length of 727 km, suggesting a maximum of 378 km of shortening since 21 Ma in the cover strata of the Indian subcontinent. Calculation of displacement rates over the Sulaiman fold-and-thrust belt (18 mm/yr) added to the resolved rate of the Chaman fault vector for the component parallel to the plate convergence direction (15 mm/yr) are close to the current India-Asia plate convergence rate (37 mm/yr). 68 refs., 13 figs.

Jadoon, I.A.K. (Quaid-i-Azam Univ., Islamabad (Panama)); Lawrence, R.D.; Lillie, R.J. (Oregon State Univ., Corvallis, OR (United States))

1994-05-01T23:59:59.000Z

5

San Juan Montana Thrust Belt WY Thrust Belt Black Warrior  

U.S. Energy Information Administration (EIA) Indexed Site

San San Juan Montana Thrust Belt WY Thrust Belt Black Warrior Paradox - San Juan NW (2) Uinta- Piceance Paradox - San Juan SE (2) Florida Peninsula Appalachian- NY (1) Appalachian OH-PA (2) Appalachian Eastern PA (3) Appalachian Southern OH (4) Appalachian Eastern WV (5) Appalachian WV-VA (6) Appalachian TN-KY (7) Piceance Greater Green River Eastern OR-WA Ventura Williston Williston NE (2) Williston NW (1) Williston South (3) Eastern Great Basin Ventura West, Central, East Eastern OR-WA Eastern Great Basin Appalachian Denver Florida Peninsula Black Warrior W Y T h ru st B e lt Powder River Paradox- Uinta- Grtr Green River MT Thrust Belt Powder River North (1) Powder River South (2) Denver North (1) Denver South (3) Denver Middle (2) TX CA MT AZ ID NV NM CO IL OR UT KS WY IA NE SD MN ND OK FL WI MO AL WA GA AR LA MI IN PA NY NC MS TN KY VA OH SC

6

The Zagros folded belt (Fars, Iran): constraints from topography and critical wedge modelling  

Science Journals Connector (OSTI)

......Asmari Formation, which is one of the main oil reservoirs in the Zagros. The folded Meso-Cenozoic...neglect the contribution of radiogenic heating in the upper crust but which is consistent...A. , Connors C., Dahlen F.A., Price E.J., Suppe J.,1994. Effect of......

F. Mouthereau; O. Lacombe; B. Meyer

2006-04-01T23:59:59.000Z

7

Petroleum geochemistry of Texas and Oklahoma oils along the Marathon—Ouachita fold-thrust belt, south-central U.S.A.  

Science Journals Connector (OSTI)

The Marathon uplifit of west Texas and the Ouachita Mountains of Oklahoma and Arkansas comprise the surface expressions of a Paleozoic orogenic belt extending across the south-central U.S.A. A century of petroleum exploration in the Marathons and Ouachitas has yielded several oil discoveries. In this study, detailed molecular, elemental and isotopic data are presented for 9 Texas oils, 5 Oklahoma oils and 4 Oklahoma solid bitumens, all associated with thrust belt rocks of west Texas and southeast Oklahoma. Oil-oil correlations are proposed, and the character of the organic matter in the source rock(s) is inferred from knowledge of the oil chemistry. At least 16 of the 18 Marathon-Ouachita fold-thrust belt oils/solid bitumens originate from the same (or very similar) organic facies, despite a geographic separation along the fold-thrust belt of > 700 mi (? 1125 km). Many of the chemical differences in these samples derive from secondary effects, including biodegradation (e.g., solid bitumens) and differing levels of thermal maturity. The occurrence of unusual chemical compounds (e.g., 25,28,30-trisnorhopane) in some samples indicates the presence of anaerobic bacteria in isolated locales during deposition. Isotopic variability, when interpreted in light of near-constant molecular composition in the oils and an extensive period of early Paleozoic “starved trough” source-rock deposition, implies that these oils originate from rocks of similar organic facies, with source-rock ages ranging from Devonian through Ordovician. Previous literature suggests either a Devonian or an Ordovician source for these oils; molecular and isotopic data of the present study do not allow a distinction to be made. These results, when interpreted in terms of depositional patterns during early Paleozoic time, suggest that oil source rocks and the Marathon-Ouachita fold-thrust belt oil type may be present in the subsurface of central and east-central Texas.

Joseph A. Curiale

1992-01-01T23:59:59.000Z

8

The vertical separation of mainshock rupture and microseismicity at Qeshm island in the Zagros fold-and-thrust belt, Iran  

E-Print Network [OSTI]

-and-thrust belt, Iran E. Nissen a, , F. Yamini-Fard b , M. Tatar b , A. Gholamzadeh b,1 , E. Bergman c , J Engineering and Seismology, PO Box 19395-3913, Tehran, Iran c Department of Physics, University of Colorado rights reserved. 1. Introduction The Zagros mountains in south-western Iran are one of the most rapidly

Elliott, John

9

Appalachian Studies Student Survey Items  

E-Print Network [OSTI]

about Appalachian culture/history Historical Survey Data (Prior to 2006) ACT Appalachian Region Alumni selected Berea College. Major Reason Minor Reason Not a Reason Cost of attendance/affordable price Close

Baltisberger, Jay H.

10

ECONOMIC IMPACT OF THE APPALACHIAN GATEWAY  

E-Print Network [OSTI]

ECONOMIC IMPACT OF THE APPALACHIAN GATEWAY PROJECT By Randall A. Childs Bureau of Business and Economic Research College of Business and Economics West Virginia University United States where demand is strong. This report documents the economic impact of the Appalachian

Mohaghegh, Shahab

11

APPALACHIAN COLLEGES COMMUNITY ECONOMIC DEVELOPMENT PARTNERSHIP  

E-Print Network [OSTI]

of ACA institutions 2. Build value-added and sustainable campus-community economic developmentAPPALACHIAN COLLEGES COMMUNITY ECONOMIC DEVELOPMENT PARTNERSHIP The UNC-Chapel Hill Office of Economic and Business Development and the Appalachian College Association proudly announce the Appalachian

Engel, Jonathan

12

Photo courtesy of Appalachian State University Appalachian State University  

E-Print Network [OSTI]

4 Report from the Appalachian State University Office of Sustainability to the American College of Sustainability Matt Parsons, Graduate Assistant Published spring 2010 A comparative survey of emissions from year to the greenhouse gas inventory completed fall 2009 by per the requirements of the American College and University

Rose, Annkatrin

13

Appalachian State | Open Energy Information  

Open Energy Info (EERE)

State State Jump to: navigation, search Name Appalachian State Facility Appalachian State Sector Wind energy Facility Type Small Scale Wind Facility Status In Service Location Boone NC Coordinates 36.21342836°, -81.69232965° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":36.21342836,"lon":-81.69232965,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

14

Facility Design Manual Appalachian State University  

E-Print Network [OSTI]

at Charlotte Design and Construction Manual University of South Carolina Sustainable Design Guidelines US DOE & US Green Building Council (USGBC) Sustainable Building Technical Manual #12;A p p a l a c h i a nFacility Design Manual Appalachian State University #12;#12;© 2009 by Appalachian State University

Thaxton, Christopher S.

15

Appalachian State University October 11, 2010  

E-Print Network [OSTI]

of Ad-hoc Committee, Chair Michael Ramey, Chair Eric Marland, Vice-Chair Jeff Butts, Parliamentarian and its functions within Appalachian State University. Peter Petschauer, Chair Steve Williams, Vice Chair

Rose, Annkatrin

16

AEP Appalachian Power - Residential Energy Efficiency Rebate...  

Energy Savers [EERE]

a completed free in-home assessment by Appalachian Power in order to qualify for rebates Heat Pumps: * Upgrade of heat pump requires minimum 14 SEER * Heat pump replacing electric...

17

Appalachian Electric Coop | Open Energy Information  

Open Energy Info (EERE)

Appalachian Electric Coop Appalachian Electric Coop Jump to: navigation, search Name Appalachian Electric Coop Place Tennessee Utility Id 727 Utility Location Yes Ownership C NERC Location SERC NERC SERC Yes Activity Distribution Yes References EIA Form EIA-861 Final Data File for 2010 - File1_a[1] Energy Information Administration Form 826[2] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Utility Rate Schedules Grid-background.png Commercial General Power rate (part 3) Commercial Commercial General Power rate (Part 2)- single phase self contained metering Commercial Commercial General Power rate (part 2)-single phase transformer rated metering Commercial Commercial General Power rate (part 2)-three phase transformer rated

18

APPALACHIAN STATE UNIVERSITY OFFICE OF GENERAL COUNSEL  

E-Print Network [OSTI]

APPALACHIAN STATE UNIVERSITY OFFICE OF GENERAL COUNSEL MEMORANDUM TO: Faculty and Staff FROM: Dayton T. Cole, General Counsel DATE: October 22, 2013 SUBJECT: Political Activity [Please print and post Resources website: http://hrs.appstate.edu/announcements/552. Questions concerning the interpretation

Thaxton, Christopher S.

19

E-Print Network 3.0 - appalachian margin foundering Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

margin foundering Page: << < 1 2 3 4 5 > >> 1 Appalachian State University Foundation, Inc. Monthly Payroll Deduction Form (A-3) Summary: Appalachian State University...

20

NYMEX Central Appalachian coal futures near-month contract final...  

Annual Energy Outlook 2013 [U.S. Energy Information Administration (EIA)]

Release Date: January 29, 2015 Next Release Date: January 2016 NYMEX Central Appalachian coal futures near-month contract final settlement price history Data as of 12312014....

Note: This page contains sample records for the topic "appalachian fold belt" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Appalachian States Low-Level Radioactive Waste Compact (Maryland)  

Broader source: Energy.gov [DOE]

This legislation authorizes Maryland's entrance into the Appalachian States Low-Level Radioactive Waste Compact, which seeks to promote interstate cooperation for the proper management and disposal...

22

Origin Basin Destination State STB EIA STB EIA Northern Appalachian...  

Gasoline and Diesel Fuel Update (EIA)

- W - W W W - W Central Appalachian Basin Alabama 26.18 26.10 -0.3% 118.06 22.1% 930 37.4% 100.0% Central Appalachian Basin Delaware 23.73 15.12 -36.3% 88.59 17.1%...

23

The Mars Hill Terrane: An enigmatic southern Appalachian terrane  

SciTech Connect (OSTI)

The Mars Hill Terrane (MHT) in the Appalachian Blue Ride Belt is bordered by complex, locally reactivated thrust and strike-slip faults. On the east, the MHT is bounded by the allochthonous, ensimatic Toe Terrane (TT) across the diachronous, ductile Holland Mountain-Soque River Fault System. The MHT is separated on the northwest from ensialic Laurentian basement (LB), by the Fries-Hayesville Fault System. On the south, the MHT is truncated by the Shope Fork Fault. The MHT is characterized by migmatitic biotite-pyroxene-hornblende gneiss, but contains 1--1.8 b.y. old quartz-feldspar gneisses, plus ultramafic rocks, calc-silicate rocks, mica schists and gneisses, and Neoproterozoic Bakersville gabbros. This rock assemblage contrasts with that of the adjoining terranes. The only correlative units between the MHT and adjoining terranes are Neoproterozoic gabbro, Ordovician-Devonian granitoid plutons, and ultramafic rocks. Gabbro links the MHT with LB rocks. Apparently similar calc-silicate rocks differ petrographically among terranes. During Taconic or Acadian events, both the TT and MHT reached amphibolite to granulite metamorphic grade, but the LB did not exceed greenschist grade. The data conflict. The O-D plutons, ultramafic rocks, and metamorphic histories suggest that the TT had docked with the MHT by Ordovician time. The premetamorphic character of the Holland Mtn.-Soque River Fault System supports that chronology. Neoproterozoic gabbros suggest a MHT-LB link by Cambrian time, but the LB experienced neither O-D plutonism nor Paleozoic amphibolite-granulite facies metamorphism.

Raymond, L.A.; Johnson, P.A. (Appalachian State Univ., Boone, NC (United States). Dept. of Geology)

1994-03-01T23:59:59.000Z

24

Deconstructing the Conveyor Belt  

Science Journals Connector (OSTI)

...deepwater formation sites. This conveyor belt is assumed to operate...oceanographers have understood that the conveyor model grossly oversimplifies...overturning: No one expects a water parcel tagged at the surface in the...Atlantic to be swept along the conveyor belt unimpeded in its equatorward...

M. Susan Lozier

2010-06-18T23:59:59.000Z

25

Solar Decathlon: Appalachian State Wins People's Choice Award |  

Broader source: Energy.gov (indexed) [DOE]

Decathlon: Appalachian State Wins People's Choice Award Decathlon: Appalachian State Wins People's Choice Award Solar Decathlon: Appalachian State Wins People's Choice Award October 3, 2011 - 10:38am Addthis On Friday, Sept. 30, 2011, U.S. Department of Energy Secretary Steven Chu spoke with Jeffrey Tiller, left, and David Lee, right, members of Appalachian State’s Solar Decathlon team. | Credit: Stefano Paltera/U.S. Department of Energy Solar Decathlon On Friday, Sept. 30, 2011, U.S. Department of Energy Secretary Steven Chu spoke with Jeffrey Tiller, left, and David Lee, right, members of Appalachian State's Solar Decathlon team. | Credit: Stefano Paltera/U.S. Department of Energy Solar Decathlon Carol Anna Communications Manager for the 2011 Solar Decathlon EDITOR'S NOTE: Originally posted on the Solar Decathlon News Blog on

26

DOE Solar Decathlon: News Blog » Appalachian State  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

'Appalachian State' 'Appalachian State' Appalachian State Wins People's Choice Award Saturday, October 1, 2011 By Carol Anna Appalachian State University won the U.S. Department of Energy Solar Decathlon 2011 People's Choice Award for its Solar Homestead today. This award gives the public the opportunity to vote for its favorite house. This year, 92,538 votes were cast. The award was announced at a Victory Reception in the solar Village in West Potomac Park-the last official event of Solar Decathlon 2011. Photo of Steven Chu shaking hands with Jeffrey Tiller as David Lee looks on. On Friday, Sept. 30, 2011, U.S. Department of Energy Secretary Steven Chu spoke with Jeffrey Tiller, left, and David Lee, right, members of Appalachian State's Solar Decathlon team. (Credit: Stefano Paltera/U.S.

27

Folding@HomeFolding@Home Vijay Pande  

E-Print Network [OSTI]

Folding@HomeFolding@Home Vijay Pande #12;http://folding.stanford.edu © Vijay S. Pande 1999,000,000 PCs on the internet Folding@Home People donate their idle computer time They visit our website://folding.stanford.edu © Vijay S. Pande 1999-2003 Folding@HomeFolding@Home:: VeryVery powerful & cost effectivepowerful & cost

Dally, William J.

28

Appalachian coal awareness conference: promoting Eastern coal  

SciTech Connect (OSTI)

Promoting the development and use of coal, especially coal from the Appalachian region, was the focus of introductory and keynote speeches and a discussion by representatives of the Virginia Coal Council, mining engineers, industry, and the Edison Electric Institute. Governor Dalton's keynote address noted that both producers and consumers attending the conference should work together to promote coal as a solution to the US energy future, and reported the impact that a commitment to coal has had on Virginia's economic growth. Participants in the coal consumers panel discussion raised various economic and regulatory issues.

Not Available

1984-01-01T23:59:59.000Z

29

Appalachian State University Campus Community Message on Ebola  

E-Print Network [OSTI]

Appalachian State University Campus Community Message on Ebola Dear Students, Welcome to campus of Health. There are many important facts found at this link including that ebola is NOT spread through air

Thaxton, Christopher S.

30

Appalachian Power Co | Open Energy Information  

Open Energy Info (EERE)

APCO) APCO) Jump to: navigation, search Name Appalachian Power Co Abbreviation APCO Affiliate Of AEP Place Ohio Service Territory Virginia, West Virginia, Tennessee Website www.appalachianpower.com Green Button Reference Page www.aep.com/newsroom/news Green Button Committed Yes Utility Id 733 Utility Location Yes Ownership I NERC Location RFC NERC RFC Yes RTO PJM Yes Operates Generating Plant Yes Activity Generation Yes Activity Transmission Yes Activity Buying Transmission Yes Activity Distribution Yes Activity Buying Distribution Yes Alt Fuel Vehicle Yes Alt Fuel Vehicle2 Yes References EIA Form EIA-861 Final Data File for 2010 - File1_a[1] Energy Information Administration Form 826[2] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now!

31

Reexamining the Cold Conveyor Belt  

Science Journals Connector (OSTI)

Despite the popularity of the conveyor-belt model for portraying the airflow through midlatitude cyclones, questions arise as to the path of the cold conveyor belt, the lower-tropospheric airflow poleward of and underneath the warm front. Some ...

David M. Schultz

2001-09-01T23:59:59.000Z

32

3-D seismic tomography of the Adelaide fold belt  

Science Journals Connector (OSTI)

......the major factor. Temperature-induced P-wave...which smoothes the temperature contrast, resulting...structure of the eastern Snake River Plain and its...1996. Upper mantle temperatures from teleseismic tomography...implications for regolith development, 3rd Australian Regolith......

Peter Clifford; Stewart Greenhalgh; Greg Houseman; Frank Graeber

2008-01-01T23:59:59.000Z

33

USING GIS TO DELINEATE HEADWATER STREAM ORIGINS IN THE APPALACHIAN COAL-BELT REGION OF KENTUCKY.  

E-Print Network [OSTI]

??Human activity such as surface mining can have substantial impacts on the natural environment. Performing a Cumulative Hydrologic Impact Assessment (CHIA) of such impacts on… (more)

Villines, Jonathan A.

2013-01-01T23:59:59.000Z

34

Appalachian Power Co (West Virginia) | Open Energy Information  

Open Energy Info (EERE)

Appalachian Power Co Appalachian Power Co Place West Virginia Utility Id 733 References Energy Information Administration.[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Utility Rate Schedules Grid-background.png G.S. - T.O.D. Commercial L.G.S. Commercial R.S. Residential R.S. - T.O.D Residential Average Rates Residential: $0.0813/kWh Commercial: $0.0731/kWh Industrial: $0.0562/kWh The following table contains monthly sales and revenue data for Appalachian Power Co (West Virginia). Month RES REV (THOUSAND $) RES SALES (MWH) RES CONS COM REV (THOUSAND $) COM SALES (MWH) COM CONS IND_REV (THOUSAND $) IND SALES (MWH) IND CONS OTH REV (THOUSAND $) OTH SALES (MWH) OTH CONS TOT REV (THOUSAND $) TOT SALES (MWH) TOT CONS

35

AEP Appalachian Power - Residential Energy Efficiency Rebate Program (West  

Broader source: Energy.gov (indexed) [DOE]

AEP Appalachian Power - Residential Energy Efficiency Rebate AEP Appalachian Power - Residential Energy Efficiency Rebate Program (West Virginia) AEP Appalachian Power - Residential Energy Efficiency Rebate Program (West Virginia) < Back Savings Category Home Weatherization Commercial Weatherization Heating & Cooling Commercial Heating & Cooling Cooling Appliances & Electronics Commercial Lighting Lighting Maximum Rebate Attic or Sidewall Insulation: $300 Basement or Crawl Space Insulation: $200 HVAC Maintenance: $100 Duct Sealing: $100 Envelope Air Infiltration Reduction: $200 Program Info Funding Source ApCo HomeSMART Program Start Date 3/11/2011 State West Virginia Program Type Utility Rebate Program Rebate Amount HVAC Maintenance: 50% of cost Insulation: $0.30/sq ft Air Source Heat Pump (replacing electric furnace): $100 or $200

36

AEP Appalachian Power - Commercial and Industrial Rebate Programs (West  

Broader source: Energy.gov (indexed) [DOE]

AEP Appalachian Power - Commercial and Industrial Rebate Programs AEP Appalachian Power - Commercial and Industrial Rebate Programs (West Virginia) AEP Appalachian Power - Commercial and Industrial Rebate Programs (West Virginia) < Back Eligibility Commercial Industrial Savings Category Heating & Cooling Commercial Heating & Cooling Cooling Other Heat Pumps Appliances & Electronics Commercial Lighting Lighting Maximum Rebate $150,000/account/year Program Info Start Date 3/11/2011 State West Virginia Program Type Utility Rebate Program Rebate Amount Custom: 50% Unitary/Split AC/Air Source Heat Pumps: $40/ton Packaged Terminal A/C: $30/ton Water/Air Cooled Chillers: $30/ton Ground Source Heat Pump: $50/ton VFDs: $40/HP Programmable Thermostat: $25/unit T8 and T5 Fluorescent Retrofits: $2-$21/fixture T8 and T5 High Bay Fixtures: $28-$209/fixture

37

Geologic Controls of Hydrocarbon Occurrence in the Appalachian Basin in Eastern Tennessee, Southwestern Virginia, Eastern Kentucky, and Southern West Virginia  

SciTech Connect (OSTI)

This report summarizes the accomplishments of a three-year program to investigate the geologic controls of hydrocarbon occurrence in the southern Appalachian basin in eastern Tennessee, southwestern Virginia, eastern Kentucky, and southern West Virginia. The project: (1) employed the petroleum system approach to understand the geologic controls of hydrocarbons; (2) attempted to characterize the P-T parameters driving petroleum evolution; (3) attempted to obtain more quantitative definitions of reservoir architecture and identify new traps; (4) is worked with USGS and industry partners to develop new play concepts and geophysical log standards for subsurface correlation; and (5) geochemically characterized the hydrocarbons (cooperatively with USGS). Third-year results include: All project milestones have been met and addressed. We also have disseminated this research and related information through presentations at professional meetings, convening a major workshop in August 2003, and the publication of results. Our work in geophysical log correlation in the Middle Ordovician units is bearing fruit in recognition that the criteria developed locally in Tennessee and southern Kentucky are more extendible than anticipated earlier. We have identified a major 60 mi-long structure in the western part of the Valley and Ridge thrust belt that has been successfully tested by a local independent and is now producing commercial amounts of hydrocarbons. If this structure is productive along strike, it will be one of the largest producing structures in the Appalachians. We are completing a more quantitative structural reconstruction of the Valley and Ridge and Cumberland Plateau than has been made before. This should yield major dividends in future exploration in the southern Appalachian basin. Our work in mapping, retrodeformation, and modeling of the Sevier basin is a major component of the understanding of the Ordovician petroleum system in this region. Prior to our undertaking this project, this system was the least understood in the Appalachian basin. This project, in contrast to many if not most programs undertaken in DOE laboratories, has a major educational component wherein three Ph.D. students have been partially supported by this grant, one M.S. student partially supported, and another M.S. student fully supported by the project. These students will be well prepared for professional careers in the oil and gas industry.

Hatcher, Robert D

2005-11-30T23:59:59.000Z

38

SLH Timing Belt Powertrain  

SciTech Connect (OSTI)

The main goal of this proposal was to develop and test a novel powertrain solution for the SLH hydroEngine?, a low-cost, efficient low-head hydropower technology. Nearly two-thirds of U.S. renewable electricity is produced by hydropower (EIA 2010). According to the U.S. Department of Energy; this amount could be increased by 50% with small hydropower plants, often using already-existing dams (Hall 2004). There are more than 80,000 existing dams, and of these, less than 4% generate power (Blankinship 2009). In addition, there are over 800 irrigation districts in the U.S., many with multiple, non-power, low-head drops. These existing, non-power dams and irrigation drops could be retrofitted to produce distributed, baseload, renewable energy with appropriate technology. The problem is that most existing dams are low-head, or less than 30 feet in height (Ragon 2009). Only about 2% of the available low-head hydropower resource in the U.S. has been developed, leaving more than 70 GW of annual mean potential low-head capacity untapped (Hall 2004). Natel Energy, Inc. is developing a low-head hydropower turbine that operates efficiently at heads less than 6 meters and is cost-effective for deployment across multiple low-head structures. Because of the unique racetrack-like path taken by the prime-movers in the SLH, a flexible powertrain is required. Historically, the only viable technological solution was roller chain. Despite the having the ability to easily attach blades, roller chain is characterized by significant drawbacks, including high cost, wear, and vibration from chordal action. Advanced carbon-#12;fiber-reinforced timing belts have been recently developed which, coupled with a novel belt attachment system developed by Natel Energy, result in a large reduction in moving parts, reduced mass and cost, and elimination of chordal action for increased fatigue life. The work done in this project affirmatively addressed each of the following 3 major uncertainties concerning a timing-belt based hydroEngine ?powertrain: 1. Can a belt handle the high torques and power loads demanded by the SLH? (Yes.) 2. Can the SLH blades be mounted to belt with a connection that can withstand the loads encountered in operation? (Yes.) 3. Can the belt, with blade attachments, live through the required cyclic loading? (Yes.) The research adds to the general understanding of sustainable small hydropower systems by using innovative system testing to develop and demonstrate performance of a novel powertrain solution, enabling a new type of hydroelectric turbine to be commercially developed. The technical effectiveness of the methods investigated has been shown to be positive through an extensive design and testing process accommodating many constraints and goals, with a major emphasis on high cycle fatigue life. Economic feasibility of the innovations has been demonstrated through many iterations of design for manufacturability and cost reduction. The project is of benefit to the public because it has helped to develop a solution to a major problem -- despite the large available potential for new low-head hydropower, high capital costs and high levelized cost of electricity (LCOE) continue to be major barriers to project development. The hydroEngine? represents a significant innovation, leveraging novel fluid mechanics and mechanical configuration to allow lower-cost turbine manufacture and development of low head hydropower resources.

Schneider, Abe

2014-04-09T23:59:59.000Z

39

1 INTRODUCTION Appalachian coal recovered during mining fre-  

E-Print Network [OSTI]

of Appalachian underground coal mining (Newman 2003). Storage of coal processing waste is limited to above ground, the impact of past and present mining on the long-term stability of the structure must be evalu- ated overlies a section of the mine workings and, therefore, long term stability of the mine work- ings

40

Replace V-Belts with Notched or Synchronous Belt Drives  

Broader source: Energy.gov [DOE]

Belt drives provide flexibility in the positioning of the motor relative to the load. Pulleys (sheaves) of varying diameters allow the speed of the driven equipment to be increased or decreased relative to the motor speed. A properly designed belt power-transmission system offers high efficiency and low noise, requires no lubrication, and presents low maintenance requirements. However, certain types of belts are more efficient than others, offering potential energy cost savings. This tip sheet provides example energy savings calculations and offers suggested actions.

Note: This page contains sample records for the topic "appalachian fold belt" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Performance evaluation of Appalachian wells using a microcomputer gas simulation model  

SciTech Connect (OSTI)

The Appalachian Basin contains very low reservoir pressures (as low as 120 psi). To help solve these problems, a one-dimensional gas simulator has been developed for use on a microcomputer. The simulation program provides production engineers with tools to generate data and determine the inflow performance relationships (IPR) of Appalachian-type wells. These Appalachian well field case studies were conducted, whereby various production methods were analyzed using the Nodal analysis method. Consequently, improved design criteria were established for selecting compatible production methods and handling production problems in the Appalachian Basin.

Yu, J.P.; Mustafa, A. (West Virginia Univ., Morgantown (USA)); Hefner, M.H. (CNG Transmission Co., Clarksburg, WV (USA))

1990-04-01T23:59:59.000Z

42

E-Print Network 3.0 - appalachian mountain region Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

10-week learning and living experience in the Appalachian Mountains. Students conduct independent... Mountain Lake Biological Station SUMMER2009 APPLY ONLINE: W W W . M L B S ....

43

E-Print Network 3.0 - appalachian silvopasture pasture Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

State University, Boone, NC Chris Thaxton... Department of Geology Carol Babyak, Ph.D., and Will Benner Department of Chemistry Appalachian State Source: Thaxton,...

44

E-Print Network 3.0 - appalachian spruce fir Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

topography, and potential insolation on the Summary: United States (Noss et al. 1995; White and Miller 1998). Appalachian montane spruce-fir forests... by wind, with natural...

45

Parametric and predictive analysis of horizontal well configurations for coalbed methane reservoirs in Appalachian Basin.  

E-Print Network [OSTI]

??It has been a well-established fact that the Appalachian Basin represents a high potential region for the Coalbed Methane (CBM) production. The thin coal beds… (more)

Maricic, Nikola.

2004-01-01T23:59:59.000Z

46

Examples from the atlas of major Appalachian Gas Plays  

SciTech Connect (OSTI)

The objectives of this contract are to produce a panted atlas of major Appalachian basin gas plays and to compile a machine-readable database of reservoir data. The Appalachian Oil and Natural Gas Research Consortium (AONGRC or the Consortium), a partnership of the state geological surveys in Kentucky, Ohio, Pennsylvania, and West Virginia, and the departments of Geology and Petroleum and Natural Gas Engineering at West Virginia University (WVU), agrees with the need to classify gas reservoirs by geologic plays. During meetings with industry representatives, the small independents in the basin emphasized that one of their prime needs was to place each producing reservoir within a stratigraphic framework subdivided by environment of deposition to enable them to develop exploration and development strategies. The text for eight of the 31 play descriptions has been completed, drafting of illustrations for these plays is underway (or complete for some plays), and the review process is ongoing.

Patchen, D.G.; Aminian, K.; Avary, K.L.; Baranoski, M.T.; Flaherty, K.; Nuttall, B.C.; Smosna, R.A.

1993-12-31T23:59:59.000Z

47

Appalachian basin coal-bed methane: Elephant or flea  

SciTech Connect (OSTI)

Historically, interest in the Appalachian basin coal-bed methane resource extends at least over the last 50 years. The Northern and Central Appalachian basins are estimated to contain 61 tcf and 5 tcf of coal-bed methane gas, respectively. Development of this resource has not kept pace with that of other basins, such as the Black Warrior basin of Alabama of the San Juan basin of northern New Mexico and Colorado. Without the benefit of modern completion, stimulation, and production technology, some older Appalachian basin coal-bed methane wells were reported to have produced in excess of 150 used here to characterize some past projects and their results. This work is not intended to comprise a comprehensive survey of all Appalachian basin projects, but rather to provide background information from which to proceed for those who may be interested in doing so. Several constraints to the development of this resource have been identified, including conflicting legal rights of ownership of the gas produced from the coal seams when coal and conventional oil and gas rights are controlled by separate parties. In addition, large leaseholds have been difficult to acquire and finding costs have been high. However, the threshold of minimum economic production may be relatively low when compared with other areas, because low-pressures pipelines are available and gas prices are among the highest in the nation. Interest in the commercial development of the resource seems to be on the increase with several projects currently active and more reported to be planned for the near future.

Hunt, A.M. (Dames and Moore, Cincinnati, OH (United States))

1991-08-01T23:59:59.000Z

48

Opportunities for Visual Resource Management in the Southern Appalachian Coal Basin1  

E-Print Network [OSTI]

Opportunities for Visual Resource Management in the Southern Appalachian Coal Basin1 John W) in the southern Appalachian coal basin resulting from the Surface Mining Control and Reclamation Act. It focuses been concerned with the visual impacts resulting from the surface mined coal the agency purchases

Standiford, Richard B.

49

Solar Decathlon Team Using Appalachian Mountain History to Model Home of  

Broader source: Energy.gov (indexed) [DOE]

Solar Decathlon Team Using Appalachian Mountain History to Model Solar Decathlon Team Using Appalachian Mountain History to Model Home of the Future Solar Decathlon Team Using Appalachian Mountain History to Model Home of the Future March 31, 2011 - 10:52am Addthis Appalachian State University’s Solar Homestead design model |courtesy of The Solar Homestead’s official Facebook page Appalachian State University's Solar Homestead design model |courtesy of The Solar Homestead's official Facebook page April Saylor April Saylor Former Digital Outreach Strategist, Office of Public Affairs How can I participate? The next Solar Decathlon will be held Sept. 23-Oct. 2, 2011, at the National Mall's West Potomac Park in Washington, D.C. Join us there! In honor of the Department of Energy's Solar Decathlon -- which challenges 20 collegiate teams to design, build, and operate solar-powered

50

Solar Decathlon Team Using Appalachian Mountain History to Model Home of  

Broader source: Energy.gov (indexed) [DOE]

Solar Decathlon Team Using Appalachian Mountain History to Model Solar Decathlon Team Using Appalachian Mountain History to Model Home of the Future Solar Decathlon Team Using Appalachian Mountain History to Model Home of the Future March 31, 2011 - 10:52am Addthis Appalachian State University’s Solar Homestead design model |courtesy of The Solar Homestead’s official Facebook page Appalachian State University's Solar Homestead design model |courtesy of The Solar Homestead's official Facebook page April Saylor April Saylor Former Digital Outreach Strategist, Office of Public Affairs How can I participate? The next Solar Decathlon will be held Sept. 23-Oct. 2, 2011, at the National Mall's West Potomac Park in Washington, D.C. Join us there! In honor of the Department of Energy's Solar Decathlon -- which challenges 20 collegiate teams to design, build, and operate solar-powered

51

Protein folding tames chaos  

E-Print Network [OSTI]

Protein folding produces characteristic and functional three-dimensional structures from unfolded polypeptides or disordered coils. The emergence of extraordinary complexity in the protein folding process poses astonishing challenges to theoretical modeling and computer simulations. The present work introduces molecular nonlinear dynamics (MND), or molecular chaotic dynamics, as a theoretical framework for describing and analyzing protein folding. We unveil the existence of intrinsically low dimensional manifolds (ILDMs) in the chaotic dynamics of folded proteins. Additionally, we reveal that the transition from disordered to ordered conformations in protein folding increases the transverse stability of the ILDM. Stated differently, protein folding reduces the chaoticity of the nonlinear dynamical system, and a folded protein has the best ability to tame chaos. Additionally, we bring to light the connection between the ILDM stability and the thermodynamic stability, which enables us to quantify the disorderli...

Xia, Kelin

2013-01-01T23:59:59.000Z

52

Energy analysis of human ecosystems in an Appalachian coal county  

SciTech Connect (OSTI)

Preliminary results from a energy analysis of the coal fuel cycle in an Appalachian coal county has provided systematic assessment of hidden energy subsidies in extraction, transport, processing, and combustion. Current results indicate a major loss due to depletion of the coal resource base by use of inefficient mining techniqus. Although of smaller magnitude, reductions in work force and community productivity from occupational accidents and disease and road maintenance requirements for transport also appear to be significant. Further assessment is needed to verify assumptions and characterize additional data bases.

Watson, A.P.

1980-01-01T23:59:59.000Z

53

Impacts of Minnesota's Primary Seat Belt Law  

E-Print Network [OSTI]

checkpoints · Motorcycle helmet mandate · Graduated driver's licenses · Automated speed Belt Law 71% 73% 73% Sobriety Checkpoints 83% 82% 82% Motorcycle Helmet Belt Law 77% 77% 70% Sobriety Checkpoints 91% 91% 90% Motorcycle Helmet

Minnesota, University of

54

Origin Basin Destination State STB EIA STB EIA Northern Appalachian Basin  

U.S. Energy Information Administration (EIA) Indexed Site

Florida W $38.51 W $140.84 27.3% 134 W 100.0% Florida W $38.51 W $140.84 27.3% 134 W 100.0% Northern Appalachian Basin Georgia - W - W W W - W Northern Appalachian Basin Indiana W $16.14 W $63.35 25.5% 1,681 W 88.5% Northern Appalachian Basin Maryland $20.69 $19.60 -5.3% $74.23 26.4% 4,845 31.9% 97.7% Northern Appalachian Basin Michigan $13.74 $16.13 17.4% $99.82 16.2% 840 32.1% 100.0% Northern Appalachian Basin New Hampshire W $40.18 W $94.03 42.7% 699 W 100.0% Northern Appalachian Basin New Jersey W $32.44 W $89.13 36.4% 1,064 W 47.6% Northern Appalachian Basin New York $21.87 $18.86 -13.8% $59.40 31.7% 2,373 49.3% 91.9%

55

Origin Basin Destination State STB EIA STB EIA Northern Appalachian Basin  

U.S. Energy Information Administration (EIA) Indexed Site

Delaware W $28.49 W $131.87 21.6% 59 W 100.0% Delaware W $28.49 W $131.87 21.6% 59 W 100.0% Northern Appalachian Basin Florida W - - - - - - - Northern Appalachian Basin Indiana W $20.35 W $64.82 31.4% 1,715 W 75.9% Northern Appalachian Basin Maryland $19.73 $19.64 -0.4% $81.15 24.2% 4,650 24.8% 99.3% Northern Appalachian Basin Michigan W $14.02 W $76.22 18.4% 713 W 100.0% Northern Appalachian Basin New Hampshire W $43.43 W $90.90 47.8% 499 W 89.6% Northern Appalachian Basin New Jersey W $27.19 W $74.81 36.3% 1,864 W 44.1% Northern Appalachian Basin New York $20.08 $15.26 -24.0% $53.68 28.4% 3,726 39.2% 79.1%

56

Multiply folded graphene  

Science Journals Connector (OSTI)

The folding of paper, hide, and woven fabric has been used for millennia to achieve enhanced articulation, curvature, and visual appeal for intrinsically flat, two-dimensional materials. For graphene, an ideal two-dimensional material, folding may transform it to complex shapes with new and distinct properties. Here, we present experimental results that folded structures in graphene, termed grafold, exist, and their formations can be controlled by introducing anisotropic surface curvature during graphene synthesis or transfer processes. Using pseudopotential-density-functional-theory calculations, we also show that double folding modifies the electronic band structure of graphene. Furthermore, we demonstrate the intercalation of C60 into the grafolds. Intercalation or functionalization of the chemically reactive folds further expands grafold's mechanical, chemical, optical, and electronic diversity.

Kwanpyo Kim; Zonghoon Lee; Brad D. Malone; Kevin T. Chan; Benjamín Alemán; William Regan; Will Gannett; M. F. Crommie; Marvin L. Cohen; A. Zettl

2011-06-27T23:59:59.000Z

57

Low rates of bedrock outcrop erosion in the central Appalachian Mountains inferred from in situ 10  

E-Print Network [OSTI]

). Davis's model persisted until Hack (1960) suggested thatAppalachian landscapes were not the dissected that landscapes evolved directionally over time, Hack proposed that landscapes only appear to preserve landforms

Vermont, University of

58

Abstract A42: Adherence to cancer screening tests among Appalachian women  

Science Journals Connector (OSTI)

...Atlanta, GA Abstract A42: Adherence to cancer screening tests among Appalachian women Electra D. Paskett Gregory...disparities in the receipt of recent cancer screening tests for each test individually (ie, mammography (MA), Pap Test...

Electra D. Paskett; Gregory Young; Michael Pennell; Mira L. Katz; Paul L. Reiter

2014-11-01T23:59:59.000Z

59

Systematic oversteepening in longitudinal profiles of mixed bedrock-alluvial channels at tributary junctions : Appalachians, Virginia  

E-Print Network [OSTI]

Certain mixed bedrock/alluvial channels located in the Valley and Ridge province of the Appalachians in Virginia were identified as having a pattern of systematic oversteepening of channel gradients at tributary junctions. ...

Windhorst, Leah M. (Leah Marie), 1981-

2004-01-01T23:59:59.000Z

60

The absence of water in certain sandstones of the Appalachian oil fields  

Science Journals Connector (OSTI)

...Waters Meteoric and Magmatic," Mining and Scientific Press, Vol. 96, pp...showingstructureof the northernpart and Appalachian coal basin. chieflyto the water contentof...coastalplain whichextendedto thehighlandsof Appalachia,stillfarthereast. Over thislow, fiat-lyingland...

Frank Reeves

Note: This page contains sample records for the topic "appalachian fold belt" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Restoring Forests and Associated Ecosystem Services on Appalachian Coal Surface Mines  

Science Journals Connector (OSTI)

Surface coal mining in Appalachia has caused extensive replacement of forest with ... forests have not been restored on most Appalachian mined lands because traditional reclamation practices, encouraged by ... sc...

Carl E. Zipper; James A. Burger; Jeffrey G. Skousen…

2011-05-01T23:59:59.000Z

62

E-Print Network 3.0 - appalachian clean coal Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

clean coal Search Powered by Explorit Topic List Advanced Search Sample search results for: appalachian clean coal Page: << < 1 2 3 4 5 > >> 1 2 April 2010 The Assistant Secretary...

63

Industrial structure and employment growth in the 1990s in Appalachian counties  

E-Print Network [OSTI]

Employment growth in the 1990s and its relationship with the initial industrial structure in 1990 are examined in the case of Appalachian counties, after controlling for labor-market conditions and other factors, such as ...

Tan, Zhijun (Zhijun Jeanne)

2005-01-01T23:59:59.000Z

64

Attitudes toward new development in three Appalachian counties  

SciTech Connect (OSTI)

Although the three West Virginia counties of this study represent distinct types of rural Appalachian areas (McDowell depends upon coal mining as the primary economic activity, Monongalia has a diversified economic base with a heavy concentration in the service sector, and Webster has low levels of economic activity and high unemployment) the study found no anti-growth sentiment in any of the counties. Residents tended to prefer the less polluting economic activities over the coal-based activities, even where the desire for new industrial growth was strong. Economic distress may lead to a suppression of environmental concern, but there is no evidence that it disappears. Future research should be sensitive to preferences for less polluting industries even when those preferences are masked. It would be worth examining the hypothesis that environmental concern has become almost a universal value. 31 references, 6 figures.

Trent, R.B.; Stout-Wiegand, N.; Smith, D.K.

1985-10-01T23:59:59.000Z

65

Stability of Appalachian coal shipments under policy variation  

SciTech Connect (OSTI)

A quadratic programming transportation model and a nonparametric statistical procedure are used to investigate how Appalachian coal-supply flows vary in response to changes in national coal markets and policies, with emphasis on the relative stability of traditional flows. The results show that the relative stability of coal shipments is preserved under small and moderate random shocks, suggesting that coal-shipment patterns remain relatively stable despite changes in the absolute level. The tendency for traditional routes to continue has occurred because of the region's access to transportation networks and its low fixed mining costs. Environmental restriction could change shipment patterns by terminating coal production in some regions. Some areas of instability may require freight subsidies. Increased taxes or changes in mining capital or generating costs could also alter the pattern. Policies to stabilize freight rates and production costs are indicated. 10 references, 8 tables.

Yang, C.W. (Clarion State Coll., PA); Labys, W.C.

1981-07-01T23:59:59.000Z

66

Synchronous and Cogged Fan Belt Performance Assessment  

SciTech Connect (OSTI)

The GSA Regional GPG Team commissioned the National Renewable Energy Laboratory (NREL) to perform monitoring of cogged V-belts and synchronous belts on both a constant volume and a variable air volume fan at the Byron G. Rodgers Federal Building and U.S. Courthouse in Denver, Colorado. These motor/fan combinations were tested with their original, standard V-belts (appropriately tensioned by an operation and maintenance professional) to obtain a baseline for standard operation. They were then switched to the cogged V-belts, and finally to synchronous belts. The power consumption by the motor was normalized for both fan speed and air density changes. This was necessary to ensure that the power readings were not influenced by a change in rotational fan speed or by the power required to push denser air. Finally, energy savings and operation and maintenance savings were compiled into an economic life-cycle cost analysis of the different belt options.

Cutler, D.; Dean, J.; Acosta, J.

2014-02-01T23:59:59.000Z

67

Protein Folding and Assembly  

Science Journals Connector (OSTI)

Abstract In order to carry out their biological functions, most polypeptide chains must fold into stable three-dimensional structures, for it is the precise spatial distribution of chemical groups within a protein that gives the molecule its ability to interact specifically with other molecules and, in the case of an enzyme, catalyze a chemical reaction. In many cases, individual polypeptide chains must also assemble into larger structures containing additional proteins or nucleic acids. The folding of many proteins is reversible, so that the native structure can be disrupted by a change in temperature or addition of a chemical denaturant, and the unfolded protein can then be induced to refold and assemble by returning it to physiological conditions. Experiments of this type demonstrate that the information specifying the native structure of a protein resides in its amino acid sequence, and in vitro studies have provided important insights into the energetic factors that drive folding and assembly and the kinetic mechanisms of these processes. Folding in vivo is often facilitated by transient interactions with other proteins, molecular chaperones. Folding may also compete with the formation of aberrant aggregates in vivo, sometimes leading to pathological conditions such as amyloid diseases.

D.P. Goldenberg

2013-01-01T23:59:59.000Z

68

Optimization Approaches to Protein Folding.  

E-Print Network [OSTI]

??This research shows optimization approaches to protein folding. The protein folding problem is to predict the compact three dimensional structure of a protein based on… (more)

Yoon, Hyun-suk

2006-01-01T23:59:59.000Z

69

Predicting protein folding pathways  

Science Journals Connector (OSTI)

......residues is a good measure of the amount of water displaced by the residue- residue contact...twodomain ?/? enzyme that maintains pools of tetrahydrofolate used in nucleotide...H.J. and Wright,P.E. (2000) Conservation of folding pathways in evolutionary distant......

Mohammed J. Zaki; Vinay Nadimpally; Deb Bardhan; Chris Bystroff

2004-08-01T23:59:59.000Z

70

Simulations of Protein Folding  

E-Print Network [OSTI]

We have developed a simple, phenomenological, Monte-Carlo code that predicts the three-dimensional structure of globular proteins from the DNA sequences that define them. We have applied this code to two small proteins, the villin headpiece (1VII) and cole1 rop (1ROP). Our code folds both proteins to within 5 A rms of their native structures.

Michael Cahill; Mark Fleharty; Kevin Cahill

1999-09-17T23:59:59.000Z

71

Protein folding: concepts and perspectives  

Science Journals Connector (OSTI)

...In this review, the main concepts of protein folding, as deduced from both theoretical and experimental...

J. M. Yon

1997-07-01T23:59:59.000Z

72

INVERSE PROTEIN FOLDING, HIERARCHICAL OPTIMISATION  

E-Print Network [OSTI]

INVERSE PROTEIN FOLDING, HIERARCHICAL OPTIMISATION AND TIE KNOTS Thomas M. A. Fink st. john Introduction 3 1.1 Inverse Protein Folding 3 1.2 Hierarchical Optimisation 5 1.3 Tie Knots 6 1.4 Schematic Organisation 6 1.5 Publications 9 2 Protein Folding, Inverse Protein Folding and Energy Landscapes 10 2

Halligan, Daniel

73

Patterns of coal workers' pneumoconiosis in Appalachian former coal miners  

SciTech Connect (OSTI)

To aid in diagnostic chest film interpretation of coal workers' pneumoconiosis, a composite profile of common radiologic patterns was developed in 98 Appalachian former coal miners who were diagnosed as having coal miner's pneumoconiosis and who applied for black lung benefits. The mean age was 61 years, with a lifetime coal mine dust exposure of 18.7 years. Results showed that chest radiographs of coal workers' simple pneumoconiosis contained small irregular linear opacities more frequently (47%) than small rounded opacities. Sparse profusion of all small opacities was the rule. Small opacities involved two out of six lung zones simultaneously 39% of the time while other combinations occurred less frequently. Lower zones were involved more frequently than upper ones. Thickened pleura occurred in 18% of radiographs. Other frequent radiographic abnormalities were parenchymal calcifications (19%), marked emphysema (12%), and inactive tuberculosis (12%). Calcification of the aortic knob, a degenerative process reflecting age, occurred in 9%. Only one instance of complicated coal workers' pneumoconiosis (progressive massive fibrosis) was encountered (0.7%). Many of the descriptive features of coal workers' pneumoconiosis noted in the literature were not observed in this study. Only one instance of complicated pneumoconiosis was encountered.43 references.

Young, R.C. Jr.; Rachal, R.E.; Carr, P.G.; Press, H.C. (College of Pharmacy, Xavier University of Louisiana, New Orleans (United States))

1992-01-01T23:59:59.000Z

74

Protein folding and cosmology  

E-Print Network [OSTI]

Protein denaturing induced by supercooling is interpreted as a process where some or all internal symmetries of the native protein are spontaneously broken. Hence, the free-energy potential corresponding to a folding-funnel landscape becomes temperature-dependent and describes a phase transition. The idea that deformed vortices could be produced in the transition induced by temperature quenching, from native proteins to unfolded conformations is discussed in terms of the Zurek mechanism that implements the analogy between vortices, created in the laboratory at low energy, and the cosmic strings which are thought to have been left after symmetry breaking phase transitions in the early universe. An experiment is proposed to test the above idea which generalizes the cosmological analogy to also encompass biological systems and push a step ahead the view that protein folding is a biological equivalent of the big bang.

González-Diáz, P F

1997-01-01T23:59:59.000Z

75

Protein folding and cosmology  

E-Print Network [OSTI]

Protein denaturing induced by supercooling is interpreted as a process where some or all internal symmetries of the native protein are spontaneously broken. Hence, the free-energy potential corresponding to a folding-funnel landscape becomes temperature-dependent and describes a phase transition. The idea that deformed vortices could be produced in the transition induced by temperature quenching, from native proteins to unfolded conformations is discussed in terms of the Zurek mechanism that implements the analogy between vortices, created in the laboratory at low energy, and the cosmic strings which are thought to have been left after symmetry breaking phase transitions in the early universe. An experiment is proposed to test the above idea which generalizes the cosmological analogy to also encompass biological systems and push a step ahead the view that protein folding is a biological equivalent of the big bang.

P. F. Gonzalez-Diaz; C. L. Siguenza

1997-06-04T23:59:59.000Z

76

Protein folding and heteropolymers  

E-Print Network [OSTI]

We present a statistical mechanics approach to the protein folding problem. We first review some of the basic properties of proteins, and introduce some physical models to describe their thermodynamics. These models rely on a random heteropolymeric description of these non random biomolecules. Various kinds of randomness are investigated, and the connection with disordered systems is discussed. We conclude by a brief study of the dynamics of proteins.

T. Garel; H. Orland; E. Pitard

1997-06-12T23:59:59.000Z

77

Folded waveguide coupler  

DOE Patents [OSTI]

A resonant cavity waveguide coupler for ICRH of a magnetically confined plasma. The coupler consists of a series of inter-leaved metallic vanes disposed withn an enclosure analogous to a very wide, simple rectangular waveguide that has been "folded" several times. At the mouth of the coupler, a polarizing plate is provided which has coupling apertures aligned with selected folds of the waveguide through which rf waves are launched with magnetic fields of the waves aligned in parallel with the magnetic fields confining the plasma being heated to provide coupling to the fast magnetosonic wave within the plasma in the frequency usage of from about 50-200 mHz. A shorting plate terminates the back of the cavity at a distance approximately equal to one-half the guide wavelength from the mouth of the coupler to ensure that the electric field of the waves launched through the polarizing plate apertures are small while the magnetic field is near a maximum. Power is fed into the coupler folded cavity by means of an input coaxial line feed arrangement at a point which provides an impedance match between the cavity and the coaxial input line.

Owens, Thomas L. (Kingston, TN)

1988-03-01T23:59:59.000Z

78

Electric filter with movable belt electrode  

DOE Patents [OSTI]

A method and apparatus for removing airborne contaminants entrained in a gas or airstream includes an electric filter characterized by a movable endless belt electrode, a grounded electrode, and a filter medium sandwiched there between. Inclusion of the movable, endless belt electrode provides the driving force for advancing the filter medium through the filter, and reduces frictional drag on the filter medium, thereby permitting a wide choice of filter medium materials. Additionally, the belt electrode includes a plurality of pleats in order to provide maximum surface area on which to collect airborne contaminants. 4 figs.

Bergman, W.

1983-09-20T23:59:59.000Z

79

Is protein folding rate dependent on number of folding stages? Modeling of protein folding with ferredoxin-like fold  

Science Journals Connector (OSTI)

Statistical analysis of protein folding rates has been done for 84 proteins ... than those with two-state kinetics. The protein folding for six proteins with a ferredoxin-like...

O. V. Galzitskaya

2010-06-01T23:59:59.000Z

80

SunBelt Biofuels | Open Energy Information  

Open Energy Info (EERE)

SunBelt Biofuels SunBelt Biofuels Jump to: navigation, search Logo: SunBelt Biofuels Name SunBelt Biofuels Place Soperton, Georgia Zip 30457 Sector Biomass Product Freedom Giant Miscanthus Website http://www.sunbeltbiofuelsllc. Coordinates 32.3771182°, -82.5923554° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":32.3771182,"lon":-82.5923554,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

Note: This page contains sample records for the topic "appalachian fold belt" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Congressional panel makes recommendations on belt safety  

SciTech Connect (OSTI)

The Mine Improvement and New Emergency Response Act of 2006 (MINER Act) called for a Technical Study Panel to present a review and make recommendations on the use of belt air and the composition and fire retardant properties of belt materials in underground coal mining. In October 2007 the Panel released 20 recommendations publicly. These are presented in the article. Many recommendations encouraged the MSHA to enforce existing laws of maintenance and fire protection or example more vigorously. Maybe the biggest change recommended was that the industry should adopt the Belt Evaluation Laboratory Test (BELT) standard proposed in 1992. Another important recommendation was one that would help eliminate hazards associated with point feeding. 1 photo.

Fiscor, S.

2007-12-15T23:59:59.000Z

82

Petaflop Computing for Protein Folding  

E-Print Network [OSTI]

"SIAM01p 2000/12/4 page 1 Petaflop Computing for Protein Folding Shannon K. Kuntz, Richard C. Murphy, Michael T. Niemier, Jesus Izaguirre, and Peter M. Kogge 1 Introduction Protein Folding the protein folding problem, while Silicon Graphics has been continually working to produce more powerful

Izaguirre, Jesús A.

83

Computer Simulations of Protein Folding  

E-Print Network [OSTI]

CHAPTER 8 Computer Simulations of Protein Folding VIJAY S. PANDE , ERIC J. SORIN , CHRISTOPHER D, CA 94305, USA 8.1 Introduction: Goals and Challenges of Simulating Protein Folding Computer as well as recent applications of this methodology. 8.1.1 Simulating Protein Folding Proteins play

Sorin, Eric J.

84

Theoretical Perspectives on Protein Folding  

E-Print Network [OSTI]

Theoretical Perspectives on Protein Folding D. Thirumalai,1 Edward P. O'Brien,2 Greg Morrison,3 Understanding how monomeric proteins fold under in vitro conditions is crucial to describing their functions remains to be done to solve the protein folding problem in the broadest sense. 159 Annu.Rev.Biophys.2010

Thirumalai, Devarajan

85

Folding and binding Editorial overview  

E-Print Network [OSTI]

is on the study of how protein folding, unfolding and aggregation reactions commence, and on the study of California, Berkeley. Her lab focuses on studies of protein folding and dynamics. Currently she­based kinetics. Much of the progress that has been made in the past fifty years in the study of protein folding

86

A COMPARISON OF RADIATION USE EFFICIENCY BETWEEN TWO SOUTHERN APPALACHIAN FORESTS  

E-Print Network [OSTI]

), intercepted photosynthetically active solar radiation (IPAR), and radiation use efficiency ( =PP/IPAR) betweenA COMPARISON OF RADIATION USE EFFICIENCY BETWEEN TWO SOUTHERN APPALACHIAN FORESTS by LUKE A. PANGLE influence the photosynthetic radiation use efficiency (PhRUE) of forest canopies. The mixed deciduous forest

Teskey, Robert O.

87

Aquatic and terrestrial invertebrate drift in southern Appalachian Mountain streams: implications for trout  

E-Print Network [OSTI]

in the southern Appalachians, ecotrophic coefficients and food conversion efficiencies. 3. Abundance and biomass invertebrate biomass was greater than aquatic larval biomass in the autumn. Drift rates of aquatic larval abundance and biomass were greatest at sunset. Inputs of terrestrial invertebrate biomass were greater than

Hutchens, John

88

Faculty Handbook Table of Contents 08/23/10 Page 1 Appalachian State University  

E-Print Network [OSTI]

for which the handbook does not provide answers. As policies, procedures, and operating guidelines whichFaculty Handbook ­ Table of Contents ­ 08/23/10 ­ Page 1 Appalachian State University FACULTY HANDBOOK Last Revised: August 23, 2010 Table of Contents FOREWORD The purpose of publishing the Faculty

Rose, Annkatrin

89

Kepler and the Kuiper Belt  

E-Print Network [OSTI]

The proposed field-of-view of the Kepler mission is at an ecliptic latitude of ~55 degrees, where the surface density of scattered Kuiper Belt Objects (KBOs) is a few percent that in the ecliptic plane. The rate of occultations of Kepler target stars by scattered KBOs with radii r>10km is ~10^-6 to 10^-4 per star per year, where the uncertainty reflects the current ignorance of the thickness of the scattered KBO disk and the faint-end slope of their magnitude distribution. These occultation events will last only ~0.1% of the planned t_exp=15 minute integration time, and thus will appear as single data points that deviate by tiny amounts. However, given the target photometric accuracy of Kepler, these deviations will nevertheless be highly significant, with typical signal-to-noise ratios of ~10. I estimate that 1-20 of the 10^5 main-sequence stars in Kepler's field-of-view will exhibit detectable occultations during its four-year mission. For unresolved events, the signal-to-noise of individual occultations scales as t_exp^{-1/2}, and the minimum detectable radius could be decreased by an order of magnitude to ~1 km by searching the individual 3-second readouts for occultations. I propose a number of methods by which occultation events may be differentiated from systematic effects. Kepler should measure or significantly constrain the frequency of highly-inclined, ~10 km-sized KBOs.

B. Scott Gaudi

2004-04-20T23:59:59.000Z

90

Protein folding in the ER.  

SciTech Connect (OSTI)

The endoplasmic reticulum (ER) is a major protein folding compartment for secreted, plasma membrane and organelle proteins. Each of these newly-synthesized polypeptides folds in a deterministic process, affected by the unique conditions that exist in the ER. An understanding of protein folding in the ER is a fundamental biomolecular challenge at two levels. The first level addresses how the amino acid sequence programs that polypeptide to efficiently arrive at a particular fold out of a multitude of alternatives, and how different sequences obtain similar folds. At the second level are the issues introduced by folding not in the cytosol, but in the ER, including the risk of aggregation in a molecularly crowded environment, accommodation of post-translational modifications and the compatibility with subsequent intracellular trafficking. This review discusses both the physicochemical and cell biological constraints of folding, which are the challenges that the ER molecular chaperones help overcome.

Stevens, F. J.; Argon, Y.; Biosciences Division; Univ. of Chicago

1999-10-01T23:59:59.000Z

91

The Geology of North America Vol. F-2, The Appalachian-OuachitaOrogen in the United States  

E-Print Network [OSTI]

- ing of the orogen are given in two other volumes in this series: Vogt and Tucholke (1986) and Sheridan., and Viele, G. W., eds., The Appalachian-Oachita Orogen in the United States: Boulder, Colorado, Geological

Olsen, Paul E.

92

Abstract 276: Appalachian mountaintop mining particulate matter induces malignant transformation and tumorigenesis of human lung epithelial cells  

Science Journals Connector (OSTI)

...276: Appalachian mountaintop mining particulate matter induces malignant...Virginia (WV), the biggest coal mining state in Appalachia, ranks the third highest rate...that living near WV mountaintop coal mining (MTM) activities is a contributing...

Sudjit Luanpitpong; Juhua Luo; Travis Kneuckles; Michael Hendryx; and Yon Rojanasakul

2014-10-01T23:59:59.000Z

93

Assessment of undiscovered carboniferous coal-bed gas resources of the Appalachian Basin and Black Warrior Basin Provinces, 2002  

SciTech Connect (OSTI)

Coalbed methane (CBM) occurs in coal beds of Mississippian and Pennsylvanian (Carboniferous) age in the Appalachian basin, which extends almost continuously from New York to Alabama. In general, the basin includes three structural subbasins: the Dunkard basin in Pennsylvania, Ohio, and northern West Virginia; the Pocahontas basin in southern West Virginia, eastern Kentucky, and southwestern Virginia; and the Black Warrior basin in Alabama and Mississippi. For assessment purposes, the Appalachian basin was divided into two assessment provinces: the Appalachian Basin Province from New York to Alabama, and the Black Warrior Basin Province in Alabama and Mississippi. By far, most of the coalbed methane produced in the entire Appalachian basin has come from the Black Warrior Basin Province. 8 refs., 1 fig., 1 tab.

Milici, R.C.; Hatch, J.R.

2004-09-15T23:59:59.000Z

94

Simulating Historic Landscape Patterns of Fire in the Southern Appalachian Mountains: Implications for Fire History and Management  

E-Print Network [OSTI]

Fire suppression policies implemented in the early 20th century led to a decrease in fire-associated species and ecosystems in the southern Appalachian Mountains. As managers work towards restoration, a greater understanding of the pre...

Gass, Ellen R

2014-05-21T23:59:59.000Z

95

Theoretical Perspectives on Protein Folding  

E-Print Network [OSTI]

Understanding how monomeric proteins fold under in vitro conditions is crucial to describing their functions in the cellular context. Significant advances both in theory and experiments have resulted in a conceptual framework for describing the folding mechanisms of globular proteins. The experimental data and theoretical methods have revealed the multifaceted character of proteins. Proteins exhibit universal features that can be determined using only the number of amino acid residues (N) and polymer concepts. The sizes of proteins in the denatured and folded states, cooperativity of the folding transition, dispersions in the melting temperatures at the residue level, and time scales of folding are to a large extent determined by N. The consequences of finite N especially on how individual residues order upon folding depends on the topology of the folded states. Such intricate details can be predicted using the Molecular Transfer Model that combines simulations with measured transfer free energies of protein building blocks from water to the desired concentration of the denaturant. By watching one molecule fold at a time, using single molecule methods, the validity of the theoretically anticipated heterogeneity in the folding routes, and the N-dependent time scales for the three stages in the approach to the native state have been established. Despite the successes of theory, of which only a few examples are documented here, we conclude that much remains to be done to solve the "protein folding problem" in the broadest sense.

D. Thirumalai; Edward P. O'Brien; Greg Morrison; Changbong Hyeon

2010-07-18T23:59:59.000Z

96

A Novel Topology for Representing Protein Folds  

E-Print Network [OSTI]

J. (2008). Predicting protein folding rates from geometric1993). Cooperativity in protein-folding kinetics. Proc NatlVoelz VA. (2007). The protein folding problem: when will it

Segal, Mark R

2009-01-01T23:59:59.000Z

97

Uncovering Allostery in a Uniquely Folded Metalloprotein /  

E-Print Network [OSTI]

M (2005) Downhill protein folding: evolution meets physics.based models for protein folding and function. Proteins:48-51). This is because protein folding and protein function

Baxter, Elizabeth Leigh

2013-01-01T23:59:59.000Z

98

Preservation of a subcritical wedge in the south Urals foreland thrust and fold belt  

Science Journals Connector (OSTI)

...274 , 224-226. Elliot, D. 1976. Energy balance and deformation mechanisms of thrust sheets. Philosophical Transactions of the Royal...Stuttgart. Mitra, G. & Boyer, S. 1985. Energy blance and deformation mechanisms of duplexes...

D. BROWN; J. ALVAREZ-MARRÓN; A. PÉREZ-ESTAÚN

99

Structural analysis of the perdido fold belt: timing, evolution, and structural style  

E-Print Network [OSTI]

the upper portion consist of fine grained and muddy siliciclastics which are typical of turbidite and other typical deep water deposits. 2-D, prestacked, depth-migrated seismic data (TGS Phase 45) was interpreted in conjunction with Hess Corporation...

Waller, Troy Dale, II

2007-09-17T23:59:59.000Z

100

Structure and evolution of the active fold and thrust belt of southwestern Taiwan using GPS geodesy  

E-Print Network [OSTI]

the westernmost exposed thrusts in this area (Figs. 3 and 4). The Chukou fault terminates to the north at the Chuchi uunsverse fault, and to the south is inferred to merge, and transfer displacement with, the Lunhou fault (Lin, 1996) just east of the Nanliao... surveys were then conducted in early 1996 and 1997 across the island using both these new monuments and pre-existing ones. These surveys were conducted with survey-grade GPS receivers on 4 to 12 sites simultaneously, with an average site occupation time...

Hickman, John Bibb

2012-06-07T23:59:59.000Z

Note: This page contains sample records for the topic "appalachian fold belt" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Mechanical characteristics of folds in Upper Cretaceous strata in the Disturbed Belt of northwestern Montana  

E-Print Network [OSTI]

Jurassic when the basin became filled with a thi. n sequence of sandstones and shales. Non-marine shale, sandstone, conglomerate, and fresh- water limestone were deposited during Late Jurassic and very Early Cretaceous. A sea from the north invaded... limestone and dolomite units. The Mississippian is directly overlain by a thin sequence of Jurassi. c clastic rocks. Above the Jut'assic lies the thick conformable sequence of alternating shales and sandstones of Cretaceous age. Together, the Jurassic...

Gilbert, Pat Kader

2012-06-07T23:59:59.000Z

102

Maps showing location of stratigraphic cross sections and cored drill holes used in the study of the Devonian black shales in the Appalachian Basin  

SciTech Connect (OSTI)

Maps were prepared showing the location of drill holes used in the stratigraphic study of black shale deposits in the Appalachian Basin. (DC)

Roen, J.B.; Wallace, L.G.; Kepferle, R.C.; Potter, P.E.; Pryor, W.A.

1980-01-01T23:59:59.000Z

103

Corn Belt Power Coop | Open Energy Information  

Open Energy Info (EERE)

Corn Belt Power Coop Corn Belt Power Coop Place Iowa Utility Id 4363 Utility Location Yes Ownership C NERC Location MRO NERC MRO Yes ISO Other Yes Operates Generating Plant Yes Activity Generation Yes Activity Transmission Yes Activity Buying Transmission Yes Activity Wholesale Marketing Yes Alt Fuel Vehicle Yes Alt Fuel Vehicle2 Yes References EIA Form EIA-861 Final Data File for 2010 - File1_a[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Utility Rate Schedules Grid-background.png No rate schedules available. Average Rates No Rates Available References ↑ "EIA Form EIA-861 Final Data File for 2010 - File1_a" Retrieved from "http://en.openei.org/w/index.php?title=Corn_Belt_Power_Coop&oldid=41053

104

Toy model for protein folding  

Science Journals Connector (OSTI)

A conceptually simple model for protein-folding phenomena has been created: it is two-dimensional and has only two different ‘‘amino acids.’’ Ground-state conformations have been determined for all of its flexible polypeptides containing seven or fewer monomers. This complete database displays a wide geometric variety of folded shapes and shows that single point mutations in some cases induce substantial folding modifications. Neural-network concepts have been employed to analyze results. The simplest static neural networks required to act as error-free read-only memories provide a way to visualize the logical structure of underlying folding principles. The topologies of optimal networks found thus far suggest that protein folding has a more complex cooperative character than has been embodied previously in theoretical approaches.

Frank H. Stillinger; Teresa Head-Gordon; Catherine L. Hirshfeld

1993-08-01T23:59:59.000Z

105

Sedimentology of gas-bearing Devonian shales of the Appalachian Basin  

SciTech Connect (OSTI)

The Eastern Gas Shales Project (1976-1981) of the US DOE has generated a large amount of information on Devonian shale, especially in the western and central parts of the Appalachian Basin (Morgantown Energy Technology Center, 1980). This report summarizes this information, emphasizing the sedimentology of the shales and how it is related to gas, oil, and uranium. This information is reported in a series of statements each followed by a brief summary of supporting evidence or discussion and, where interpretations differ from our own, we include them. We believe this format is the most efficient way to learn about the gas-bearing Devonian shales of the Appalachian Basin and have organized our statements as follows: paleogeography and basin analysis; lithology and internal stratigraphy; paleontology; mineralogy, petrology, and chemistry; and gas, oil, and uranium.

Potter, P.E.; Maynard, J.B.; Pryor, W.A.

1981-01-01T23:59:59.000Z

106

Basement faults and seismicity in the Appalachian Basin of New York State  

Science Journals Connector (OSTI)

Landsat lineaments identified by Earth Satellite Corporation (EARTHSAT, 1997) can be groundtruthed across the Appalachian Basin of New York State (NYS). Both fracture intensification domains (FIDs) and faults are observed in outcrop along the lineaments. Confirmation of deep structure associated with the surface structure is provided by both well log analyses and seismic reflection data (primarily proprietary). Additional faults are proposed by comparing the lineament locations with gravity and magnetic data. The result is a web of basement faults that crisscross New York State. By overlaying epicenter locations on the fault/lineament maps, it is possible to observe the spatial correlation between seismic events and the faults. Every seismic event in the Appalachian Basin portion of NYS lies on or near a known or suspected fault. It thus appears that not only are there more faults than previously suspected in NYS, but also, many of these faults are seismically active.

Robert D Jacobi

2002-01-01T23:59:59.000Z

107

Protein Folding Rates Correlate with Heterogeneity of Folding Mechanism  

Science Journals Connector (OSTI)

By observing trends in the folding kinetics of experimental 2-state proteins at their transition midpoints, and by observing trends in the barrier heights of numerous simulations of coarse-grained, C? model G? proteins, we show that folding rates correlate with the degree of heterogeneity in the formation of native contacts. Statistically significant correlations are observed between folding rates and measures of heterogeneity inherent in the native topology, as well as between rates and the variance in the distribution of either experimentally measured or simulated ? values.

B. Öztop; M. R. Ejtehadi; S. S. Plotkin

2004-11-12T23:59:59.000Z

108

Coalbed methane technology development in the Appalachian basin. Topical Report, July 1989-October 1990  

SciTech Connect (OSTI)

The primary objective of the field-based research is to determine the applicability of the current coalbed methane technology to the production of gas from the Appalachian Basin coal resource. Related objectives are to: (1) provide techniques to characterize and hydraulically stimulate this resource; (2) predict and measure gas production and correlate with assumed production mechanisms; (3) disseminate information learned to interested parties; and (4) recommend further research to optimize production from this resource.

Hunt, A.M.; Steele, D.J.

1991-01-01T23:59:59.000Z

109

Simulation of CO2 Sequestration and Enhanced Coalbed Methane Production in Multiple Appalachian Basin Coal Seams  

SciTech Connect (OSTI)

A DOE-funded field injection of carbon dioxide is to be performed in an Appalachian Basin coal seam by CONSOL Energy and CNX Gas later this year. A preliminary analysis of the migration of CO2 within the Upper Freeport coal seam and the resulting ground movements has been performed on the basis of assumed material and geometric parameters. Preliminary results show that ground movements at the field site may be in a range that are measurable by tiltmeter technology.

Bromhal, G.S.; Siriwardane, H.J.; Gondle, R.K.

2007-11-01T23:59:59.000Z

110

Historical geography of economic development in Appalachian Kentucky, 1800-1930  

SciTech Connect (OSTI)

This study hypothesizes that Appalachian Kentucky's nineteenth century commercial economic development was as significant as coal mining in shaping economic patterns which appeared during the depression years of the 1930's. Testing of this hypothesis permits the evaluation of widely-held views of the region's development. The economic landscape of the 1800's has generally been thought of as a rather homogeneous unit, isolated from outside commercial linkages, and almost wholly dominated by subsistence agriculture. This study concludes that the region's nineteenth century economy was: 1) spatially and structurally more complex than has previously been recognized, 2) not by-passed by national economic growth in 1850, as previous research indicates; and 3) characterized by some commercial agriculture rather than the subsistence stereotype presented in other works. Appalachian Kentucky did not develop as a unified economic entity. Complexities of the region's development have been masked by generalization and by stereotypes formed on impressions from limited areas. A clearer understanding of Appalachian economic development may be achieved if conventional assessments of the region are interpreted with caution.

Moore, T.G. Jr.

1984-01-01T23:59:59.000Z

111

Fast events in protein folding  

SciTech Connect (OSTI)

The primary objective of this work was to develop a molecular understanding of how proteins achieve their native three-dimensional (folded) structures. This requires the identification and characterization of intermediates in the protein folding process on all relevant timescales, from picoseconds to seconds. The short timescale events in protein folding have been entirely unknown. Prior to this work, state-of-the-art experimental approaches were limited to milliseconds or longer, when much of the folding process is already over. The gap between theory and experiment is enormous: current theoretical and computational methods cannot realistically model folding processes with lifetimes longer than one nanosecond. This unique approach to employ laser pump-probe techniques that combine novel methods of laser flash photolysis with time-resolved vibrational spectroscopic probes of protein transients. In this scheme, a short (picosecond to nanosecond) laser photolysis pulse was used to produce an instantaneous pH or temperature jump, thereby initiating a protein folding or unfolding reaction. Structure-specific, time-resolved vibrational probes were then used to identify and characterize protein folding intermediates.

Woodruff, W.; Callender, R.; Causgrove, T.; Dyer, R.; Williams, S.

1996-04-01T23:59:59.000Z

112

Hydrodynamic Description of Protein Folding  

Science Journals Connector (OSTI)

A hydrodynamic description of protein folding is proposed and illustrated with a lattice protein model, which has a free energy surface (FES) typical of proteins with two-state folding kinetics. The flows from the unfolded to the native state are concentrated in a limited region of the FES. The rest is occupied by a flow “vortex”, which does not lead to the native state. In contrast with intermediates that are associated with local minima, the vortex is not visible on the FES. The hydrodynamic interpretation thus provides new insights into the mechanism of protein folding and can be a useful complement to standard analyses.

Sergei F. Chekmarev; Andrey Yu. Palyanov; Martin Karplus

2008-01-11T23:59:59.000Z

113

Simplified Models of Protein Folding  

Science Journals Connector (OSTI)

Protein folding is one of the most basic physico-...1...]. As in all theoretical endeavors, the degree of simplification in modeling protein behavior depends on the questions to be addressed. The motivations for ...

Hue Sun Chan

2005-01-01T23:59:59.000Z

114

Dominant Pathways in Protein Folding  

Science Journals Connector (OSTI)

We present a method to investigate the kinetics of protein folding and the dynamics underlying the formation of secondary and tertiary structures during the entire reaction. By writing the solution of the Fokker-Planck equation in terms of a path integral, we derive a Hamilton-Jacobi variational principle from which we are able to compute the most probable pathway of folding. The method is applied to the folding of the Villin headpiece subdomain simulated using a Go model. An initial collapsing phase driven by the initial configuration is followed by a rearrangement phase, in which secondary structures are formed and all computed paths display strong similarities. This completely general method does not require the prior knowledge of any reaction coordinate and is an efficient tool to perform simulations of the entire folding process with available computers.

P. Faccioli; M. Sega; F. Pederiva; H. Orland

2006-09-06T23:59:59.000Z

115

Protein Folding Sculpting Evolutionary Change  

E-Print Network [OSTI]

Our work suggests that the forces that govern protein folding exert a profound effect on how genotypes are translated into phenotypes and that this in turn has strong effects on evolutionary processes. Molecular chaperones, ...

Lindquist, Susan

116

Characterization of protein folding intermediates  

SciTech Connect (OSTI)

The three-dimensional structure of a protein is encoded in its linear sequence of amino acids. Studies of protein folding are aimed at understanding the nature of this code which translates one-dimensional information to three-dimensions. It is now well-established that protein folding intermediates exist and can be populated significantly under some conditions. A method to characterize kinetic folding intermediates is described. The method takes advantage of the decrease in exchange rates between amide protons (i.e., peptide backbone NH) and solvent water protons, when the amide proton is involved in structure. The feasibility of using amide proton exchange to pulse-label proteins during folding has been demonstrated using (/sup 3/H)-H/sub 2/O. The results with ribonuclease A (RNase A) support a framework model for folding, in which the secondary structure of a protein is formed before tertiary structure changes are complete. Extension of these studies using NMR should permit characterization of early secondary structure folding frameworks.

Kim, P.S.

1986-01-01T23:59:59.000Z

117

Introduction to Grid computing Protein folding  

E-Print Network [OSTI]

Introduction to Grid computing Protein folding Protein folding is an extremely hot topic in medical research these days, unfortunately protein folding is extremely computationally demanding and requires a huge supercomputer to fold even the simplest proteins. Luckily the task of calculating protein foldings

Boyar, Joan

118

Corn Belt Energy Corporation | Open Energy Information  

Open Energy Info (EERE)

Corn Belt Energy Corporation Corn Belt Energy Corporation Place Illinois Utility Id 4362 Utility Location Yes Ownership C NERC Location RFC NERC RFC Yes ISO MISO Yes Activity Transmission Yes Activity Distribution Yes Activity Bundled Services Yes References EIA Form EIA-861 Final Data File for 2010 - File1_a[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Utility Rate Schedules Grid-background.png INDUSTRIAL SUBSTATION RATE ("ISR") Industrial RATE 1 RESIDENTIAL & FARM SERVICE Residential RATE 10 ELECTRIC HEAT FOR RESIDENTIAL & FARM SERVICE Residential RATE 11 RESIDENTIAL & FARM SERVICE - INTERRUPTIBLE Residential RATE 12 RESIDENTIAL ELECTRICALLY HEATED APARTMENTS Residential

119

A motion planning approach to protein folding  

E-Print Network [OSTI]

Protein folding is considered to be one of the grand challenge problems in biology. Protein folding refers to how a protein's amino acid sequence, under certain physiological conditions, folds into a stable close-packed three-dimensional structure...

Song, Guang

2004-09-30T23:59:59.000Z

120

Principles of Chaperone-Mediated Protein Folding  

Science Journals Connector (OSTI)

...Principles of Chaperone-Mediated Protein Folding F. Ulrich Hartl The recent discovery...coordinated pathway of cellular protein folding. Principles of chaperone-mediated protein folding. | The recent discovery of molecular...

1995-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "appalachian fold belt" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Pathway and Stability of Protein Folding  

Science Journals Connector (OSTI)

...research-article Pathway and Stability of Protein Folding Alan R. Fersht Mark Bycroft...experimental approach to the problem of protein folding and stability which measures...helices. Pathway and stability of protein folding. | We describe an experimental...

1991-01-01T23:59:59.000Z

122

Models of Cooperativity in Protein Folding  

Science Journals Connector (OSTI)

...research-article Models of Cooperativity in Protein Folding Hue Sun Chan Sarina Bromberg...two-state cooperativity of protein folding? Since the 1950s, three main...Models of cooperativity in protein folding. | What is the basis for the...

1995-01-01T23:59:59.000Z

123

Investigating Protein Folding and Function by Manipulating Rare and Partially-Folded Conformations  

E-Print Network [OSTI]

and G.D. Rose, The protein-folding problem: the native foldZ. Zhou, and Y. Bai, A protein folding pathway with multipleintermediate state in protein folding by a hydrophobic

Horner, Geoffrey Ashworth

2010-01-01T23:59:59.000Z

124

Journal Article: Simplified Protein Models: Predicting Folding...  

Office of Scientific and Technical Information (OSTI)

Simplified Protein Models: Predicting Folding Pathways and Structure Using Amino Acid Sequences Citation Details Title: Simplified Protein Models: Predicting Folding Pathways and...

125

Search for: "protein folding" | DOE PAGES  

Office of Scientific and Technical Information (OSTI)

"protein folding" Find + Advanced Search Advanced Search All Fields: "protein folding" Title: Full Text: Bibliographic Data: Creator Author: Name Name ORCID Search Authors...

126

Folding for binding or binding for folding? Amedeo Caflisch  

E-Print Network [OSTI]

that there exist soluble proteins which lack a well-defined folded structure or contain disordered segments [1, 2]. A computational approach trained on known proteins with intrinsic disorder has pre- dicted unstructured regions-425, 2003. It is posted with permission from Elsevier. November 20, 2003 Abstract A number of proteins

Caflisch, Amedeo

127

Turbulent phenomena in protein folding  

Science Journals Connector (OSTI)

Protein folding and hydrodynamic turbulence are two long-standing challenges, in molecular biophysics and fluid dynamics, respectively. The theories of these phenomena have been developed independently and used different formalisms. Here we show that the protein folding flows can be surprisingly similar to turbulent fluid flows. Studying a benchmark model protein (an SH3 domain), we have found that the flows for the slow folding trajectories of the protein, in which a partly formed N- and C-terminal ? sheet hinders the RT loop from attaching to the protein core, have many properties of turbulent flows of a fluid. The flows are analyzed in a three-dimensional (3D) space of collective variables, which are the numbers of native contacts between the terminal ? strands, between the RT loop and the protein core, and the rest of the native contacts. We have found that the flows have fractal nature and are filled with 3D eddies; the latter contain strange attractors, at which the tracer flow paths behave as saddle trajectories. Two regions of the space increment have been observed, in which the flux variations are self-similar with the scaling exponent h=1/3, in surprising agreement with the Kolmogorov inertial range theory of turbulence. In one region, the cascade of protein rearrangements is directed from larger to smaller scales (net folding), and in the other, it is oppositely directed (net unfolding). Folding flows for the fast trajectories are essentially “laminar” and do not have the property of self-similarity. Based on the results of our study, we infer, and support this inference by simulations, that the origin of the similarity between the protein folding and turbulent motion of a fluid is in a cascade mechanism of structural transformations in the systems that underlies these phenomena.

Igor V. Kalgin and Sergei F. Chekmarev

2011-01-31T23:59:59.000Z

128

Feasibility study of heavy oil recovery in the Appalachian, Black Warrior, Illinois, and Michigan basins  

SciTech Connect (OSTI)

This report is one of a series of publications assessing the feasibility of increasing domestic heavy oil production. Each report covers select areas of the United States. The Appalachian, Black Warrior, Illinois, and Michigan basins cover most of the depositional basins in the Midwest and Eastern United States. These basins produce sweet, paraffinic light oil and are considered minor heavy oil (10{degrees} to 20{degrees} API gravity or 100 to 100,000 cP viscosity) producers. Heavy oil occurs in both carbonate and sandstone reservoirs of Paleozoic Age along the perimeters of the basins in the same sediments where light oil occurs. The oil is heavy because escape of light ends, water washing of the oil, and biodegradation of the oil have occurred over million of years. The Appalachian, Black Warrior, Illinois, and Michigan basins` heavy oil fields have produced some 450,000 bbl of heavy oil of an estimated 14,000,000 bbl originally in place. The basins have been long-term, major light-oil-producing areas and are served by an extensive pipeline network connected to refineries designed to process light sweet and with few exceptions limited volumes of sour or heavy crude oils. Since the light oil is principally paraffinic, it commands a higher price than the asphaltic heavy crude oils of California. The heavy oil that is refined in the Midwest and Eastern US is imported and refined at select refineries. Imports of crude of all grades accounts for 37 to >95% of the oil refined in these areas. Because of the nature of the resource, the Appalachian, Black Warrior, Illinois and Michigan basins are not expected to become major heavy oil producing areas. The crude oil collection system will continue to degrade as light oil production declines. The demand for crude oil will increase pipeline and tanker transport of imported crude to select large refineries to meet the areas` liquid fuels needs.

Olsen, D.K.; Rawn-Schatzinger, V.; Ramzel, E.B.

1992-07-01T23:59:59.000Z

129

Feasibility study of heavy oil recovery in the Appalachian, Black Warrior, Illinois, and Michigan basins  

SciTech Connect (OSTI)

This report is one of a series of publications assessing the feasibility of increasing domestic heavy oil production. Each report covers select areas of the United States. The Appalachian, Black Warrior, Illinois, and Michigan basins cover most of the depositional basins in the Midwest and Eastern United States. These basins produce sweet, paraffinic light oil and are considered minor heavy oil (10{degrees} to 20{degrees} API gravity or 100 to 100,000 cP viscosity) producers. Heavy oil occurs in both carbonate and sandstone reservoirs of Paleozoic Age along the perimeters of the basins in the same sediments where light oil occurs. The oil is heavy because escape of light ends, water washing of the oil, and biodegradation of the oil have occurred over million of years. The Appalachian, Black Warrior, Illinois, and Michigan basins' heavy oil fields have produced some 450,000 bbl of heavy oil of an estimated 14,000,000 bbl originally in place. The basins have been long-term, major light-oil-producing areas and are served by an extensive pipeline network connected to refineries designed to process light sweet and with few exceptions limited volumes of sour or heavy crude oils. Since the light oil is principally paraffinic, it commands a higher price than the asphaltic heavy crude oils of California. The heavy oil that is refined in the Midwest and Eastern US is imported and refined at select refineries. Imports of crude of all grades accounts for 37 to >95% of the oil refined in these areas. Because of the nature of the resource, the Appalachian, Black Warrior, Illinois and Michigan basins are not expected to become major heavy oil producing areas. The crude oil collection system will continue to degrade as light oil production declines. The demand for crude oil will increase pipeline and tanker transport of imported crude to select large refineries to meet the areas' liquid fuels needs.

Olsen, D.K.; Rawn-Schatzinger, V.; Ramzel, E.B.

1992-07-01T23:59:59.000Z

130

Los Alamos provides HOPE for radiation belt storm probes  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

HOPE for radiation belt storm probes HOPE for radiation belt storm probes Los Alamos provides HOPE for radiation belt storm probes The HOPE analyzer is one of a suite of instruments that was successfully launched as part of the Radiation Belt Storm Probe mission. August 30, 2012 Artist's rendering showing two spacecraft representing the not-yet-designed Radiation Belt Storm Probes that will study the sun and its effects on Earth. PHOTO CREDIT: Johns Hopkins University Applied Physics Laboratory Artist's rendering showing two spacecraft representing the not-yet-designed Radiation Belt Storm Probes that will study the sun and its effects on Earth. PHOTO CREDIT: Johns Hopkins University Applied Physics Laboratory Contact James E. Rickman Communications Office (505) 665-9203 Email "Today we are boldly going where no spacecraft ever wants to go."

131

Energy analysis of the coal fuel cycle in an Appalachian coal county  

SciTech Connect (OSTI)

Preliminary results from an energy analysis of the coal fuel cycle in an Appalachian coal county have provided a systematic assessment of hidden energy subsidies in extraction, transport, processing, and combustion. Current results indicate that the system operates at an annual energy deficit of approximately 350 x 10/sup 10/ kcal. A major loss is depletion of the coal resource base by use of inefficient mining techniques. Although of smaller magnitude, reductions in work force and community productivity from occupational accidents, disease, and road maintenance requirements for transport also appear to be significant. Further assessment is needed to verify assumptions and characterize additional data bases. 39 references.

Watson, A.P.

1984-03-01T23:59:59.000Z

132

New compounds will help coal operators comply with BELT standards  

SciTech Connect (OSTI)

US coal producers will soon have a new set of conveyor belting standards, which are currently proposed as a rulemaking by the Mine Safety and Health Administration (MSHA), to bring higher levels of resistance to propagation of fire by a secondary source. The new test being put into effect is known as a Belt Evaluation Laboratory Test (BELT). The article, submitted by Fenner Dunlop, discusses the company's testing procedures and the development of conveyors to comply with regulations. 2 photos.

NONE

2009-04-15T23:59:59.000Z

133

Dominant Pathways in Protein Folding  

E-Print Network [OSTI]

We present a method to investigate the kinetics of protein folding on a long time-scale and the dynamics underlying the formation of secondary and tertiary structures during the entire reaction. The approach is based on the formal analogy between thermal and quantum diffusion: by writing the solution of the Fokker-Planck equation for the time-evolution of a protein in a viscous heat-bath in terms of a path integral, we derive a Hamilton-Jacobi variational principle from which we are able to compute the most probable pathway of folding. The method is applied to the folding of the Villin Headpiece Subdomain, in the framework of a Go-model. We have found that, in this model, the transition occurs through an initial collapsing phase driven by the starting coil configuration and a later rearrangement phase, in which secondary structures are formed and all computed paths display strong similarities. This method is completely general, does not require the prior knowledge of any reaction coordinate and represents an efficient tool to perfom ab-initio simulations of the entire folding process with available computers.

P. Faccioli; M. Sega; F. Pederiva; H. Orland

2006-07-27T23:59:59.000Z

134

Folding in regions of extension  

Science Journals Connector (OSTI)

......isostatically compensated and why the Moho remains flat in such regions. Finally, the model accounts...extensional folds from examples in the Rocky Mountain Basin and Range province, U...the Basin and Range-Colorado Plateau-Rocky Mountain transition from coherence analysis......

F. Lévy; C. Jaupart

2011-06-01T23:59:59.000Z

135

Folding in regions of extension  

Science Journals Connector (OSTI)

......For the large crustal temperatures that are implied by the small...interesting feature is the Snake River Plain at the northern...implications for fold and rock fabric development, central Mojave metamorphic...Evans B., 1979. Stress and temperature in the bending lithosphere......

F. Lévy; C. Jaupart

2011-06-01T23:59:59.000Z

136

Magnetic refrigeration apparatus with belt of ferro or paramagnetic material  

DOE Patents [OSTI]

A magnetic refrigerator operating in the 12 to 77 K range utilizes a belt which carries ferromagnetic or paramagnetic material and which is disposed in a loop which passes through the center of a solenoidal magnet to achieve cooling. The magnetic material carried by the belt, which can be blocks in frames of a linked belt, can be a mixture of substances with different Curie temperatures arranged such that the Curie temperatures progressively increase from one edge of the belt to the other. This magnetic refrigerator can be used to cool and liquefy hydrogen or other fluids.

Barclay, J.A.; Stewart, W.F.; Henke, M.D.; Kalash, K.E.

1986-04-03T23:59:59.000Z

137

Disulfide-Linked Protein Folding Pathways  

E-Print Network [OSTI]

Disulfide-Linked Protein Folding Pathways Bharath S. Mamathambika1,3 and James C. Bardwell2,3, 1 of protein folding is difficult because it involves the identification and characterization of folding to protein folding in vitro and in vivo. 211 Click here for quick links to Annual Reviews content online

Bardwell, James

138

1. THE RADIATION BELTS The outer zone radiation belts consist of energetic elec-  

E-Print Network [OSTI]

a variety of time scales. There is a noted association between solar wind speed and relativistic elec- tron and external processes. This paper reviews what is currently understood of the interactions between energetic, A Review of ULF Interactions with Radiation Belt Electrons Scot R. Elkington Laboratory for Atmospheric

Elkington, Scot R.

139

A new stratigraphic framework for the Gaspé Belt in southern Quebec: implications for the pre-Acadian Appalachians of eastern Canada  

Science Journals Connector (OSTI)

...Natural Resources and Energy, 26th Annual review...Natural Resources and Energy, Minerals and Energy Division, Mineral Resources...laterally equivalent. Independant evidence supports the...Resources Canada Quebec City, QC Canada Malo Michel...

Denis Lavoie; Esther Asselin

140

The Mings Bight Ophiolite Complex, Newfoundland: Appalachian oceanic crust W. S. F.KIDD AND JOHN F. DEWEY  

E-Print Network [OSTI]

781 The Mings Bight Ophiolite Complex, Newfoundland: Appalachian oceanic crust and mantle W. S. F, Ithaca, NY 14850, U.S.A. Received September 19, 1977 Revision accepted January 9, 1978 The Mings Bight that the ophiolite complex was generated as the the floor of a small rear-arc or intra-arc basin. The ophiolite

Kidd, William S. F.

Note: This page contains sample records for the topic "appalachian fold belt" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Shale characterization and resource appraisal of Devonian black shales of the Appalachian basin. Quarterly report for October to December 1981  

SciTech Connect (OSTI)

The objective is to characterize the Devonian shales of the Appalachian basins. Status of each of the following projects are briefly presented for the month of December; stratigraphy; geophysics; geochemistry; structure study; conodont maturation-paleontology; geochemistry-trace element study; data systems; clay mineralogy; and resource appraisal. (ATT)

Not Available

1981-01-01T23:59:59.000Z

142

Higher coronary heart disease and heart attack morbidity in Appalachian coal mining regions  

Science Journals Connector (OSTI)

Background This study analyzes the U.S. 2006 Behavioral Risk Factor Surveillance System survey data (N = 235,783) to test whether self-reported cardiovascular disease rates are higher in Appalachian coal mining counties compared to other counties after control for other risks. Methods Dependent variables include self-reported measures of ever (1) being diagnosed with cardiovascular disease (CVD) or with a specific form of CVD including (2) stroke, (3) heart attack, or (4) angina or coronary heart disease (CHD). Independent variables included coal mining, smoking, BMI, drinking, physician supply, diabetes co-morbidity, age, race/ethnicity, education, income, and others. SUDAAN Multilog models were estimated, and odds ratios tested for coal mining effects. Results After control for covariates, people in Appalachian coal mining areas reported significantly higher risk of CVD (OR = 1.22, 95% CI = 1.14–1.30), angina or CHD (OR = 1.29, 95% CI = 1.19–1.39) and heart attack (OR = 1.19, 95% CI = 1.10–1.30). Effects were present for both men and women. Conclusions Cardiovascular diseases have been linked to both air and water contamination in ways consistent with toxicants found in coal and coal processing. Future research is indicated to assess air and water quality in coal mining communities in Appalachia, with corresponding environmental programs and standards established as indicated.

Michael Hendryx; Keith J. Zullig

2009-01-01T23:59:59.000Z

143

Economic monitoring of a contour surface mine in steep slope Appalachian topography  

SciTech Connect (OSTI)

Accurate estimates of the costs of various surface mining unit operations in steep Appalachian topography are seldom encountered, but are essential to assessment of the feasibility of improving mined land reclamation via Controlled Overburden Placement (COP) procedures. The purposes and methods of monitoring economic costs and overburden movement at a steeply sloping Appalachian contour surface mine in Wise County, Virginia, are discussed. The monitoring program consists of three phases: daily records of machinery operation, monthly site visits to record mining progress, and studies of unit operations at the Amos Ridge site and at other sites in the area. The monitoring program is designed to allow precise estimates to be made of the machine hours required to move and place defined amounts of overburden under specified conditions. Limitations to the accuracy of such estimates are detailed. Accurate economic information on various mining procedures will facilitate the evaluation of tradeoffs between costs and environmental effects, as is necessary to make effective public policy decisions which affect mine reclamation practice.

Zipper, C.E.; Daniels, W.L.

1984-12-01T23:59:59.000Z

144

Reserves and potential supply of low-sulfur Appalachian coal. Final report  

SciTech Connect (OSTI)

This project has two objectives. The first is to develop and test a methodology for determining economically mineable reserves of low-sulfur Appalachian coal. The second is to appraise the potential supply response to a very large increase in demand for low-sulfur Appalachian coal. The reserve determination procedure developed in the project applies criteria similar to those employed by mining engineers in assessing the commercial feasibility of mining properties. The procedure is relatively easy to apply, could be used to develop reserve estimates for a large sample of mining blocks for under $500,000, and produces reserve estimates very different from those produced from the criteria that have been used by the United States Bureau of Mines: with the more rigorous method developed in this project surface mineable reserves are much larger and deep mineable reserves are less than with the Bureau of Mines method. The appraisal of potential low-sulfur coal supply response assessed excess capacity, coal mining company outlook on reserves, and coal quality requirements. The appraisal concluded that ample coal meeting most buyers' requirements will probably be available in the near or long term at a price under $45 in 1984 dollars. However, coal quality requirements may prove a constraint for some buyers, and an upward surge in prices would probably occur in the event of legislation imposing requirements leading to greatly increased low-sulfur coal demand. 14 refs., 24 figs., 15 tabs.

Hughes, W.R.

1986-09-01T23:59:59.000Z

145

Fractured gas reservoirs in the Devonian shale of the Illinois and Appalachian basins  

SciTech Connect (OSTI)

The Devonian and Lower Mississippian black shale sequence of Kentucky includes the New Albany Shale of Illinois basin and the Ohio Shale of the Appalachian basin. Fractured reservoirs in the Ohio Shale contain a major gas resource, but have not been so prolific in the New Albany Shale. The authors propose two models of fractured shale reservoirs in both the Illinois and the Appalachian basins, to be tested with gas production data. (1) Where reactivated basement faults have propagated to the surface, the lack of an effective seal has prevented the development of overpressure. The resulting fracture system is entirely tectonic is origin, and served mainly as a conduit for gas migration from the basin to the surface. Gas accumulations in such reservoirs typically are small and underpressured. (2) Where basement faults have been reactivated but have not reached the surface, a seal on the fractured reservoir is preserved. In areas where thermal maturity has been adequate, overpressuring due to gas generation resulted in a major extension of the fracture system, as well as enhanced gas compression and adsorption. Such gas accumulations are relatively large. Original overpressuring has been largely lost, due both to natural depletion and to uncontrolled production. The relative thermal immaturity of the Illinois basin accounts for the scarcity of the second type of fractured reservoir and the small magnitude of the New Albany Shale gas resource.

Hamilton-Smith, T.; Walker, D.; Nuttall, B. (Kentucky Geological Survey, Lexington (United States))

1991-08-01T23:59:59.000Z

146

Protein folding using contact maps  

E-Print Network [OSTI]

We present the development of the idea to use dynamics in the space of contact maps as a computational approach to the protein folding problem. We first introduce two important technical ingredients, the reconstruction of a three dimensional conformation from a contact map and the Monte Carlo dynamics in contact map space. We then discuss two approximations to the free energy of the contact maps and a method to derive energy parameters based on perceptron learning. Finally we present results, first for predictions based on threading and then for energy minimization of crambin and of a set of 6 immunoglobulins. The main result is that we proved that the two simple approximations we studied for the free energy are not suitable for protein folding. Perspectives are discussed in the last section.

Michele Vendruscolo; Eytan Domany

1999-01-21T23:59:59.000Z

147

Polymer Uncrossing and Knotting in Protein Folding, and Their Role in Minimal Folding Pathways  

E-Print Network [OSTI]

Polymer Uncrossing and Knotting in Protein Folding, and Their Role in Minimal Folding Pathways Ali induce dominant pathway mechanisms in protein folding. Citation: Mohazab AR, Plotkin SS (2013) Polymer Uncrossing and Knotting in Protein Folding, and Their Role in Minimal Folding Pathways. PLoS ONE 8(1): e53642

Plotkin, Steven S.

148

Folding pathway of a lattice model for protein folding Vijay S. Pande1  

E-Print Network [OSTI]

Folding pathway of a lattice model for protein folding Vijay S. Pande1 and Daniel S. Rokhsar1 principles that describe protein folding, then one might expect them to apply to simplified models

Croquette, Vincent

149

CREATING A GEOLOGIC PLAY BOOK FOR TRENTON-BLACK RIVER APPALACHIAN BASIN EXPLORATION  

SciTech Connect (OSTI)

Private- and public-sector stakeholders formed the new ''Trenton-Black River Appalachian Basin Exploration Consortium'' and began a two-year research effort that will lead to a play book for Trenton-Black River exploration throughout the Appalachian basin. The final membership of the Consortium includes 17 gas exploration companies and 6 research team members, including the state geological surveys in Kentucky, Ohio, Pennsylvania and West Virginia, the New York State Museum Institute and West Virginia University. Seven integrated research tasks are being conducted by basin-wide research teams organized from this large pool of experienced professionals. More than 3400 miles of Appalachian basin digital seismic data have been quality checked. In addition, inquiries have been made regarding the availability of additional seismic data from government and industry partners in the consortium. Interpretations of the seismic data have begun. Error checking is being performed by mapping the time to various prominent reflecting horizons, and analyzing for any anomalies. A regional geological velocity model is being created to make time-to-depth conversions. Members of the stratigraphy task team compiled a generalized, basin-wide correlation chart, began the process of scanning geophysical logs and laid out lines for 16 regional cross sections. Two preliminary cross sections were constructed, a database of all available Trenton-Black River cores was created, and a basin-wide map showing these core locations was produced. Two cores were examined, described and photographed in detail, and were correlated to the network of geophysical logs. Members of the petrology team began the process of determining the original distribution of porous and permeable facies within a sequence stratigraphic framework. A detailed sedimentologic and petrographic study of the Union Furnace road cut in central Pennsylvania was completed. This effort will facilitate the calibration of subsurface core and log data. A core-sampling plan was developed cooperatively with members of the isotope geochemistry and fluid inclusion task team. One hundred thirty (130) samples were prepared for trace element and stable isotope analysis, and six samples were submitted for strontium isotope analysis. It was learned that there is a good possibility that carbon isotope stratigraphy may be a useful tool to locate the top of the Black River Formation in state-to-state correlations. Gas samples were collected from wells in Kentucky, New York and West Virginia. These were sent to a laboratory for compositional, stable isotope and hydrogen and radiogenic helium isotope analysis. Decisions concerning necessary project hardware, software and configuration of the website and database were made by the data, GIS and website task team. A file transfer protocol server was established for project use. The project website is being upgraded in terms of security.

Douglas G. Patchen; James Drahovzal; Larry Wickstrom; Taury Smith; Chris Laughery; Katharine Lee Avary

2004-04-01T23:59:59.000Z

150

Molecular Dynamics Simulations of Protein Folding  

Science Journals Connector (OSTI)

I illustrate the use of the replica exchange molecular dynamics (REMD) algorithm to study the folding of a small (57 amino acids) protein that folds into a three-helix bundle, protein A. The REMD is a triviall...

Angel E. Garcia

2008-01-01T23:59:59.000Z

151

Topology to geometry in protein folding: -Lactoglobulin  

E-Print Network [OSTI]

Topology to geometry in protein folding: -Lactoglobulin Ariel Ferna´ndez* , Andre´s Colubri , and R angles and at the -carbon atoms of the peptide backbone dominate protein folding. Next in importance

Berry, R. Stephen

152

THE INFLUENCE OF FOLD AND FRACTURE DEVELOPMENT ON RESERVOIR BEHAVIOR OF THE LISBURNE GROUP OF NORTHERN ALASKA  

SciTech Connect (OSTI)

The Lisburne Group is a major carbonate reservoir unit in northern Alaska. The Lisburne is detachment folded where it is exposed throughout the northeastern Brooks Range, but is relatively undeformed in areas of current production in the subsurface of the North Slope. The objectives of this study are to develop a better understanding of four major aspects of the Lisburne: (1) The geometry and kinematics of detachment folds and their truncation by thrust faults. (2) The influence of folding and lithostratigraphy on fracture patterns. (3) Lithostratigraphy and its influence on folding, faulting, fracturing, and reservoir characteristics. (4) The influence of lithostratigraphy and deformation on fluid flow. The results of field work during the summer of 1999 offer some preliminary insights: The Lisburne Limestone displays a range of symmetrical detachment fold geometries throughout the northeastern Brooks Range. The variation in fold geometry suggests a generalized progression in fold geometry with increasing shortening: Straight-limbed, narrow-crested folds at low shortening, box folds at intermediate shortening, and folds with a large height-to-width ratio and thickened hinges at high shortening. This sequence is interpreted to represent a progressive change in the dominant shortening mechanism from flexural-slip at low shortening to bulk strain at higher shortening. Structural variations in bed thickness occur throughout this progression. Parasitic folding accommodates structural thickening at low shortening and is gradually succeeded by penetrative strain as shortening increases. The amount of structural thickening at low to intermediate shortening may be inversely related to the local amount of structural thickening of the Kayak Shale, the incompetent unit that underlies the Lisburne. The Lisburne Limestone displays a different structural style in the south, across the boundary between the northeastern Brooks Range and the main axis of the Brooks Range fold-and-thrust belt. The steep forelimbs of angular asymmetrical folds typically have been cut and displaced by thrust faults, resulting in superposition of a fault-bend fold geometry on the truncated folds. Remnant uncut folds within trains of thrust-truncated folds and the predominance of detachment folds to the north suggest that these folds originated as detachment folds. Fold asymmetry and a more uniformly competent Lisburne Limestone may have favored accommodation of a significant proportion of shortening by thrust faulting, in contrast with the dominance of fold shortening to the north. Two dominant sets of fractures are present in the least deformed Lisburne Limestone: Early extension fractures normal to the regional fold trend and late extension and shear fractures parallel to the regional fold trend. These two major fracture sets remain as deformation increases, but they are more variable in orientation, character, and relative age. Compared to fold limbs, the fold hinges display greater density and extent of fractures, more conjugate and shear fractures, and more evidence of penetrative strain. This suggests that hinges remained fixed during fold growth. Late extension fractures normal to the fold axis are common even where penetrative strain is greatest. Fracture density is greater in fine-grained carbonates than in coarse-grained carbonates over the entire spectrum of deformation.

Wesley K. Wallace; Catherine L. Hanks; Michael T. Whalen; Jerry Jensen; Paul K. Atkinson; Joseph S. Brinton

2000-05-01T23:59:59.000Z

153

EXPLORING PROTEIN FOLDING TRAJECTORIES USING GEOMETRIC SPANNERS  

E-Print Network [OSTI]

EXPLORING PROTEIN FOLDING TRAJECTORIES USING GEOMETRIC SPANNERS D. RUSSEL and L. GUIBAS Computer of secondary and tertiary structures as the protein folds. 1 Introduction There has been extensive work understanding of protein folding by studying their ensemble behaviors. Most currently used methods

Guibas, Leonidas J.

154

Protein folding: not just another optimization  

E-Print Network [OSTI]

Protein folding: not just another optimization problem Kevin Karplus karplus of California, Santa Cruz protein-folding: not just opt ­ p.1/68 #12;Outline of Talk What is Bioinformatics initio" methods Contact prediction protein-folding: not just opt ­ p.2/68 #12;What is Bioinformatics

Karplus, Kevin

155

UNCORRECTED 3 Protein folding: Then and now  

E-Print Network [OSTI]

UNCORRECTED PROOF 1 2 Review 3 Protein folding: Then and now 4 Yiwen Chen 1 , Feng Ding 1 , Huifen 8 9 Abstract 10 Over the past three decades the protein folding field has undergone monumental changes. Originally a purely academic question, how 11 a protein folds has now become vital

Dokholyan, Nikolay V.

156

Atomistic Protein Folding Simulations on the  

E-Print Network [OSTI]

Atomistic Protein Folding Simulations on the Submillisecond Time Scale Using Worldwide Distributed Abstract: Atomistic simulations of protein folding have the potential to be a great complement. Biopolymers 68: 91­109, 2003 Keywords: atomistic protein folding; microsecond time scale; computer hardware

Snow, Christopher

157

Thermodynamics of Protein Folding Erik Sandelin  

E-Print Network [OSTI]

Thermodynamics of Protein Folding and Design Erik Sandelin Department of Theoretical Physics Lund Sölvegatan 14A 223 62 LUND September 2000 Erik Sandelin Thermodynamics of Protein Folding and Design The protein folding and protein design problems are addressed, using coarse-grained models with only two types

Sandelin, Erik

158

272 Dispatch Protein folding: Chaperones get Hip  

E-Print Network [OSTI]

272 Dispatch Protein folding: Chaperones get Hip Thomas Ziegelhoffer, Jill L. Johnson and Elizabeth the complexity of the Hsp70 `chaperone machine' that mediates early steps of protein folding in cells. Address of protein folding and translocation through their ability to recognize non-native conformations of proteins

Craig, Elizabeth A

159

Approximate Inference and Protein-Folding  

E-Print Network [OSTI]

Approximate Inference and Protein-Folding Chen Yanover and Yair Weiss School of Computer Science Side-chain prediction is an important subtask in the protein-folding problem. We show that #12;nding algorithms, including a widely used protein-folding software (SCWRL). 1 Introduction Inference in graphical

Weiss, Yair

160

Prediction of surface deformations over longwall panels in the Northern Appalachian Coalfield  

SciTech Connect (OSTI)

This paper describes the Bureau of Mines development of a novel subsidence prediction methodology suitable to the mining and geologic conditions in the Northern Appalachian Coal Region. It describes the computation of vertical and horizontal movements, inclination, curvature, and horizontal strains. The substance of this method is the separation of the effects of lithology by introducing a correlation between hypothetically homogenous overburden and existing lithologic conditions, while providing for different mining conditions such as underground geometry and overburden thickness. The effects of lithology have been expressed in the form of a variable subsidence coefficient within the subsidence trough. Results from additional longwall panel studies not included in the regression analysis were used to prove the validity of this method. To facilitate the use of this pre-calculation methodology, a computer program was written in BASIC for use on a personal computer.

Adamek, V.; Jeran, P.W.; Trevitz, M.A.

1987-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "appalachian fold belt" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Appalachian coal miner mortality study: a 14-year follow-up  

SciTech Connect (OSTI)

From 1963 to 1965, the U.S. Public Health Service examined 3,726 underground Appalachian bituminous coal miners who were living in 1962. Their vital status was verified on January 1, 1973 (10 years of follow-up) and again on January 1, 1976 (14 years of follow-up). Mortality was studied after 10 years and results were published by Ortmeyer (1974) and Costello (1974, 1975). The results of a study of the mortality after 14 years are the subject of this report. The cause of death was determined from the underlying cause recorded on the death certificate. Death from all causes, ischemic heart disease, non-malignant respiratory disease (NMRD), cancer of the trachea, bronchus, and lung, digestive cancer, and accidents were studied.

Amandus, H.

1982-06-08T23:59:59.000Z

162

Precalculation of subsidences over longwall panels in the Northern Appalachian Coal Field  

SciTech Connect (OSTI)

The specific lithological conditions over the Pittsburgh coalbed, highly resistive limestone and sandstone units with relatively shallow overburden, prevent the use of any predictive method as developed for European conditions. This paper describes the development of a subsidence precalculation methodology suitable to the mining-geological conditions in the Northern Appalachian Coal Field. It has been found that due to lithological conditions over the Pittsburgh coalbed the subsidence coefficient varies within the area of the subsidence trough. This is different from the European conditions where the subsidence coefficient is considered to be a constant. The effects of lithology, in the form of a variable subsidence coefficient, have been separated for each test site by introducing a correlation between hypothetically homogeneous overburden and existing lithological conditions, while providing for different mining conditions.

Adamek, V.; Jeran, P.W.

1985-01-01T23:59:59.000Z

163

Microsoft Word - MRCSP Appalachian Basin 2008 FactSheet _09-08_-2.doc  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

R.E. Burger Site 1 September 2008 R.E. Burger Site 1 September 2008 FACT SHEET FOR PARTNERSHIP FIELD VALIDATION TEST Midwest Regional Carbon Sequestration Partnership (MRCSP) NETL Cooperative Agreement DE-FC26-05NT42589 DOE/NETL Project Manager: Lynn Brickett, Lynn.Brickett@NETL.DOE.GOV Submitted by Battelle September 2008 Appalachian Basin Geologic Test at R.E. Burger Power Plant Principal Investigator Dave Ball, Battelle (614-424-4901; balld@battelle.org) Test Location FirstEnergy R.E. Burger Plant, Shadyside, Ohio Amount and Source of CO 2 1,000-3,000 metric tons Source = commercial source FirstEnergy Ohio Geological Survey (Ohio Department of Natural Resources) Field Test Partners (Primary Sponsors) Summary of Field Test Site and Operations:

164

Introducing Protein Folding Using Simple Models  

E-Print Network [OSTI]

We discuss recent theoretical developments in the study of simple lattice models of proteins. Such models are designed to understand general features of protein structures and mechanism of folding. Among the topics covered are (i) the use of lattice models to understand the selection of the limited set of viable protein folds; (ii) the relationship between structure and sequence spaces; (iii) the application of lattice models for studying folding mechanisms (topological frustration, kinetic partitioning mechanism). Classification of folding scenarios based on the intrinsic thermodynamic properties of a sequence (namely, the collapse and folding transition temperatures) is outlined. A brief discussion of random heteropolymer model is also presented.

D. Thirumalai; D. K. Klimov

2001-01-04T23:59:59.000Z

165

Structural and Energetic Heterogeneity in Protein Folding  

E-Print Network [OSTI]

A general theoretical framework is developed using free energy functional methods to understand the effects of heterogeneity in the folding of a well-designed protein. Native energetic heterogeneity arising from non-uniformity in native stability, as well as entropic heterogeneity intrinsic to the topology of the native structure are both investigated as to their impact on the folding free energy landscape and resulting folding mechanism. Given a minimally frustrated protein, both structural and energetic heterogeneity lower the thermodynamic barrier to folding, and designing in sufficient heterogeneity can eliminate the barrier at the folding transition temperature. Sequences with different distributions of stability throughout the protein and correspondingly different folding mechanisms may still be good folders to the same structure. This theoretical framework allows for a systematic study of the coupled effects of energetics and topology in protein folding, and provides interpretations and predictions for future experiments which may investigate these effects.

Steven S. Plotkin; Jose N. Onuchic

2000-09-27T23:59:59.000Z

166

Protein Folding Trajectories Analysis: Summarization, Event Detection and Consensus Partial Folding Pathway  

E-Print Network [OSTI]

Protein Folding Trajectories Analysis: Summarization, Event Detection and Consensus Partial Folding in protein folding trajectories. We pro- pose an approach that employs the simplicity of contact maps and po- tentially cure diseases caused by misfolding. The protein folding problem is therefore one

Yang, Hui

167

Computational investigations of folded self-avoiding walks related to protein folding  

E-Print Network [OSTI]

Computational investigations of folded self-avoiding walks related to protein folding Jacques M, protein folding, protein structure prediction 1. Introduction Self-avoiding walks (SAWs) have been studied, 9], authors of this manuscript have investigated some dynamic protein folding models. They have

Paris-Sud XI, Université de

168

A review of recent advances in ab initio protein folding by the Folding@home project  

E-Print Network [OSTI]

A review of recent advances in ab initio protein folding by the Folding@home project William Ito molecular simulations of protein folding. Thanks to engineering innovations like a Graphical Processing Unit power, allowing it to simulate longer and more complex protein folding mechanisms than ever before

169

Warm Conveyor Belts in Idealized Moist Baroclinic Wave Simulations  

Science Journals Connector (OSTI)

This idealized modeling study of moist baroclinic waves addresses the formation of moist ascending airstreams, so-called warm conveyor belts (WCBs), their characteristics, and their significance for the downstream flow evolution. Baroclinic wave ...

Sebastian Schemm; Heini Wernli; Lukas Papritz

2013-02-01T23:59:59.000Z

170

A 15-Year Climatology of Warm Conveyor Belts  

Science Journals Connector (OSTI)

This study presents the first climatology of so-called warm conveyor belts (WCBs), strongly ascending moist airstreams in extratropical cyclones that, on the time scale of 2 days, rise from the boundary layer to the upper troposphere. The ...

Sabine Eckhardt; Andreas Stohl; Heini Wernli; Paul James; Caroline Forster; Nicole Spichtinger

2004-01-01T23:59:59.000Z

171

Protein-Folding Landscapes in Multi-Chain Systems  

E-Print Network [OSTI]

a common approach to studying protein folding in isolationto investigate protein folding in the presence of multipleProtein-Folding Landscapes in Multi-Chain Systems Major

Cellmer, Troy; Bratko, Dusan; Prausnitz, John M.; Blanch, Harvey

2005-01-01T23:59:59.000Z

172

Protein-folding via divide-and-conquer optimization  

E-Print Network [OSTI]

Protein-folding vianumerical optimization Protein folding via divide-and-premise brings the protein-folding problem into the realm of

Oliva, Ricardo; Crivelli, Silvia; Meza, Juan

2004-01-01T23:59:59.000Z

173

Intermediates and the folding of proteins L and G  

E-Print Network [OSTI]

unifying mechanism for protein folding? [Review]. Trends incoordinate for protein folding. Journal of Chemical PhysicsIntermediates can accelerate protein folding. Proceedings of

Brown, Scott; Head-Gordon, Teresa

2008-01-01T23:59:59.000Z

174

Folding amphipathic helices into membranes: Amphiphilicity trumps hydrophobicity  

E-Print Network [OSTI]

C. (1999). Membrane protein folding and stability: PhysicalA. S. & Hristova, K. (1998). Protein folding in membranes:Mutational analysis of protein folding and stability. In

Fernández-Vidal, Mónica; Jayasinghe, Sajith; Ladokhin, Alexey S; White, Stephen H

2007-01-01T23:59:59.000Z

175

Extending the theoretical framework of protein folding dynamics  

E-Print Network [OSTI]

Stochastic Dynamics on a Protein Folding Energy Landscape .and J. N. Onuchic. Protein folding funnels: kinetic pathwaysthe energy landscape of protein folding. Proteins: Struct.

Yang, Sichun

2006-01-01T23:59:59.000Z

176

On the rough folding landscape of green fluorescent protein  

E-Print Network [OSTI]

H. (2008). Understanding protein folding: small proteins inmultiple pathways of protein folding. Chem Biol 2, 255-60.Polymer principles and protein folding. Protein Sci 8, 1166-

Andrews, Benjamin Thomas

2008-01-01T23:59:59.000Z

177

Basinwide fold evolution and geometric development of cratonic - foreland basin interaction  

SciTech Connect (OSTI)

Latest results of the Williston Basin Project incorporate a north-south regional seismic line, which is crossing the deepest part of the Williston Basin from Saskatchewan to South Dakota. The integration of this new profile to the two, existing east-west regional seismic sections, gives a quasi-3D image of the basin. The combined seismic data illustrate alternating extensive and compressive phases during basin development, marked by basinwide circular and radial folds. This alternating pattern of basin subsidence is the very nature of crotonic basin evolution. The structural necessity for compressive phases during crotonic basin subsidence, is shown in a regional scale interpretation that has undergone an Earth-curvature correction. The geometrical evolution of the neighboring foreland basin is also interpreted from data that has been corrected with the Earth-curvature function. It shows that basinwide folds sub-parallel and perpendicular to the longitudinal axis of the basin are analogous to the circular and radial folds of the crotonic basins. These folds, in the foreland belt, are less pronounced because larger scale structural elements can overprint them. Where the crotonic and foreland basins overlap, a complex, deformed zone is present, and contains late stage volcanism, in this area. The geometry of the Williston Basin can be modeled by the Sloss-type [open quote]inverted Gaussian function[close quote] that is modified by the periodic westward tilting of the basin and the Earth-curvature function.

Redly, P.; Hajnal, Z. (Univ. of Saskatchewan, Saskatoon (Canada))

1996-01-01T23:59:59.000Z

178

Basinwide fold evolution and geometric development of cratonic - foreland basin interaction  

SciTech Connect (OSTI)

Latest results of the Williston Basin Project incorporate a north-south regional seismic line, which is crossing the deepest part of the Williston Basin from Saskatchewan to South Dakota. The integration of this new profile to the two, existing east-west regional seismic sections, gives a quasi-3D image of the basin. The combined seismic data illustrate alternating extensive and compressive phases during basin development, marked by basinwide circular and radial folds. This alternating pattern of basin subsidence is the very nature of crotonic basin evolution. The structural necessity for compressive phases during crotonic basin subsidence, is shown in a regional scale interpretation that has undergone an Earth-curvature correction. The geometrical evolution of the neighboring foreland basin is also interpreted from data that has been corrected with the Earth-curvature function. It shows that basinwide folds sub-parallel and perpendicular to the longitudinal axis of the basin are analogous to the circular and radial folds of the crotonic basins. These folds, in the foreland belt, are less pronounced because larger scale structural elements can overprint them. Where the crotonic and foreland basins overlap, a complex, deformed zone is present, and contains late stage volcanism, in this area. The geometry of the Williston Basin can be modeled by the Sloss-type {open_quote}inverted Gaussian function{close_quote} that is modified by the periodic westward tilting of the basin and the Earth-curvature function.

Redly, P.; Hajnal, Z. [Univ. of Saskatchewan, Saskatoon (Canada)

1996-12-31T23:59:59.000Z

179

Protein Vivisection Reveals Elusive Intermediates in Folding  

SciTech Connect (OSTI)

Although most folding intermediates escape detection, their characterization is crucial to the elucidation of folding mechanisms. Here, we outline a powerful strategy to populate partially unfolded intermediates: A buried aliphatic residue is substituted with a charged residue (e.g., Leu {yields} Glu{sup -}) to destabilize and unfold a specific region of the protein. We applied this strategy to ubiquitin, reversibly trapping a folding intermediate in which the {beta}5-strand is unfolded. The intermediate refolds to a native-like structure upon charge neutralization under mildly acidic conditions. Characterization of the trapped intermediate using NMR and hydrogen exchange methods identifies a second folding intermediate and reveals the order and free energies of the two major folding events on the native side of the rate-limiting step. This general strategy may be combined with other methods and have broad applications in the study of protein folding and other reactions that require trapping of high-energy states.

Zheng, Zhongzhou; Sosnick, Tobin R. (UC)

2010-05-25T23:59:59.000Z

180

Cotranslational protein folding with L-systems  

E-Print Network [OSTI]

Abstract. A protein molecule adopts a specific 3D structure, necessary for its function in the cell, through a process of folding. Modelling the folding process and predicting the final fold from the unique amino acid sequence remain challenging problems. We have previously described the application of L-systems, parallel rewriting rules, to modelling protein folding using two complementary approaches: a physics-based approach, using calculations of interatomic forces, and a knowledge-based approach, using data from fragments of known protein structures. Here we describe a model combining these two approaches creating an adaptive stochastic open L-systems model of protein folding. L-systems were originally developed to model growth and development. Here we also describe extensions of our L-systems models to investigate cotranslational protein folding, i.e. folding during protein biosynthesis on the ribosome, which is increasingly thought to play an important role. We demonstrate that cotranslational folding fits very naturally into the L-systems framework. Key words: Cotranslational protein folding, L-systems 1

Gemma B. Danks; Susan Stepney; Leo S. D. Caves

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181

Protein Folding: Generalized-Ensemble Algorithms  

Science Journals Connector (OSTI)

We briefly review the development of generalized-ensemble optimization techniques and their application since publication of “Protein Folding: Generalized-Ensemble Algorithms” was published in...

Ulrich H. E. Hansmann

2009-01-01T23:59:59.000Z

182

Simulating Temperature Jumps for Protein Folding Studies.  

E-Print Network [OSTI]

??Protein folding is described as a dynamic process of an ensemble of molecules reaching well-defined three dimensional structures to achieve biological activity from linear amino… (more)

Kim, Seonah

2007-01-01T23:59:59.000Z

183

Microsoft Word - RNA_folding_Herschlag.doc  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

March 2003 Exploring the Folding Landscape of a Structured RNA by SAXS Rick Russell, Ian S. Millett, Sebastian Doniach and Daniel Herschlag Stanford University One goal of genome...

184

The sedimentological and geotechnical characteristics of the lower continental slope and rise of the Mississippi Fan fold belt  

E-Print Network [OSTI]

The study is based on geological and geotechnical laboratory testing data of 70 three inch diameter piston cores. Concentration is along the Sigsbee Escarpment in a grid area between 90? and 91?W and 26.7? and 27.3?N. Water depth ranges from 1...

Ramazanova, Rahila

2012-06-07T23:59:59.000Z

185

Sedimentation and basin-fill history of the Neogene clastic succession exposed in the southeastern fold belt of the  

E-Print Network [OSTI]

-water base-of-slope clastics overlain by thick slope mud that passes upward into shallow marine and nearshore at Dallas, 2601 North Floyd Road, Richardson, TX 75038-0688, USA. www.elsevier.com/locate/sedgeo Sedimentary and exploitation strategy for hydrocarbon plays that may prove vital to the oil companies engaged in exploration

Kulp, Mark

186

Heterogeneous deformation in a ductile fold-thrust belt: The Proterozoic structural history of the Tusas Mountains, New Mexico  

Science Journals Connector (OSTI)

...and mica "fish" in mylonitic quartz- ite of the Taos and Cimmaron Ranges (Gram- bling and others, 1989; J. A. Grambling...sional tectonic event such as that proposed for the Taos and Cimmaron Ranges (Grambling and others, 1989). Grambling and others...

187

Structural Insight into RNA Hairpin Folding Intermediates Gregory R. Bowman,  

E-Print Network [OSTI]

on the Folding@home infrastructure to obtain better sampling and, therefore, greater insight into RNA folding

Guibas, Leonidas J.

188

3.2 Energetics of Protein Folding  

Science Journals Connector (OSTI)

Protein is only marginally stable as a result of a small net difference between large contributions of stabilizing and destabilizing forces. This article reviews the contribution of various energetic factors such as the hydrophobic effect, hydrogen bonding, electrostatic interaction, and conformation entropy to protein folding. Based on our current understanding of the protein-folding energetic, strategies to improve protein stability are discussed.

K.-B. Wong; T.-H. Yu; C.-H. Chan

2012-01-01T23:59:59.000Z

189

STATISTICAL ANALYSIS OF PROTEIN FOLDING KINETICS  

E-Print Network [OSTI]

STATISTICAL ANALYSIS OF PROTEIN FOLDING KINETICS AARON R. DINNER New Chemistry Laboratory for Protein Folding: Advances in Chemical Physics, Volume 120. Edited by Richard A. Friesner. Series Editors Experimental and theoretical studies have led to the emergence of a unified general mechanism for protein

Dinner, Aaron

190

Angle stations in or for endless conveyor belts  

DOE Patents [OSTI]

In an angle station for an endless conveyor belt, there are presented to each incoming run of the belt stationary curved guide members (18, 19) of the shape of a major segment of a right-circular cylinder and having in the part-cylindrical portion (16 or 17) thereof rectangular openings (15) arranged in parallel and helical paths and through which project small freely-rotatable rollers (14), the continuously-changing segments of the curved surfaces of which projecting through said openings (15) are in attitude to change the direction of travel of the belt (13) through 90.degree. during passage of the belt about the part-cylindrical portion (16 or 17) of the guide member (18 or 19). The rectangular openings (15) are arranged with their longer edges lengthwise of the diagonals representing the mean of the helix but with those of a plurality of the rows nearest to each end of the part-cylindrical portion (16 or 17) slightly out of axial symmetry with said diagonals, being slightly inclined in a direction about the intersections (40) of the diagonals of the main portion of the openings, to provide a "toe-in" attitude in relation to the line of run of the endless conveyor belt.

Steel, Alan (Glasgow, GB6)

1987-04-07T23:59:59.000Z

191

Fan-fold shielded electrical leads  

DOE Patents [OSTI]

Disclosed are fan-folded electrical leads made from copper cladded Kapton, for example, with the copper cladding on one side serving as a ground plane and the copper cladding on the other side being etched to form the leads. The Kapton is fan folded with the leads located at the bottom of the fan-folds. Electrical connections are made by partially opening the folds of the fan and soldering, for example, the connections directly to the ground plane and/or the lead. The fan folded arrangement produces a number of advantages, such as electrically shielding the leads from the environment, is totally non-magnetic, and has a very low thermal conductivity, while being easy to fabricate. 3 figs.

Rohatgi, R.R.; Cowan, T.E.

1996-06-11T23:59:59.000Z

192

Single-molecule studies of riboswitch folding  

Science Journals Connector (OSTI)

Abstract The folding dynamics of riboswitches are central to their ability to modulate gene expression in response to environmental cues. In most cases, a structural competition between the formation of a ligand-binding aptamer and an expression platform (or some other competing off-state) determines the regulatory outcome. Here, we review single-molecule studies of riboswitch folding and function, predominantly carried out using single-molecule FRET or optical trapping approaches. Recent results have supplied new insights into riboswitch folding energy landscapes, the mechanisms of ligand binding, the roles played by divalent ions, the applicability of hierarchical folding models, and kinetic vs. thermodynamic control schemes. We anticipate that future work, based on improved data sets and potentially combining multiple experimental techniques, will enable the development of more complete models for complex RNA folding processes. This article is part of a Special Issue entitled: Riboswitches.

Andrew Savinov; Christian F. Perez; Steven M. Block

2014-01-01T23:59:59.000Z

193

Spoil handling and reclamation costs at a contour surface mine in steep slope Appalachian topography  

SciTech Connect (OSTI)

Accurate overburden handling cost estimation methods are essential to effective pre-mining planning for post-mining landforms and land uses. With the aim of developing such methods, the authors have been monitoring costs at a contour surface mine in Wise County, Virginia since January 1, 1984. Early in the monitoring period, the land was being returned to its Approximate Original Contour (AOC) in a manner common to the Appalachian region since implementation of the Surface Mining Control and Reclamation Act of 1977 (SMCRA). More recently, mining has been conducted under an experimental variance from the AOC provisions of SMCRA which allowed a near-level bench to be constructed across the upper surface of two mined points and an intervening filled hollow. All mining operations are being recorded by location. The cost of spoil movement is calculated for each block of coal mined between January 1, 1984, and August 1, 1985. Per cubic yard spoil handling and reclamation costs are compared by mining block. The average cost of spoil handling was $1.90 per bank cubic yard; however, these costs varied widely between blocks. The reasons for those variations included the landscape positions of the mining blocks and spoil handling practices. The average reclamation cost was $0.08 per bank cubic yard of spoil placed in the near level bench on the mined point to $0.20 for spoil placed in the hollow fill. 2 references, 4 figures.

Zipper, C.E.; Hall, A.T.; Daniels, W.L.

1985-12-09T23:59:59.000Z

194

Estimates of central Appalachian coal reserves by cost of production and sulfur content  

SciTech Connect (OSTI)

This study provides information on the quantity, quality, and production costs for all minable coal reserves in the major coal-producing counties of central Appalachia, a region that contains the large majority of low-sulfur and compliance coal reserves in the eastern US. Presently, the best source of detailed reserve information in the Appalachian region is the estimates produced by the mining and land holding companies that control the reserves. The authors have been able to obtain overall reserve estimates based on the detailed geological and engineering studies conducted by these companies. In areas where this information does not exist, the authors have relied on published estimates of reserves and modified these estimates based on known conditions on surrounding properties. This reserve information has been combined with data on coal quality and mining costs to produce cost curves for all minable coal reserves by sulfur content. Results to date indicate that most of the major coal-producing counties in central Appalachia will be able to increase production levels significantly on a sustainable basis for at least the next 20 years, without major real increases in coal prices.

Watkins, J.

1988-08-01T23:59:59.000Z

195

Environmental aspects of coal production in the Appalachian region. Final project report  

SciTech Connect (OSTI)

A comprehensive, multiyear study of environmental effects related to steep slope surface mining has integrated hydrology, water quality, geology, and biology at a single study area in the Appalachian Coal fields of northeast Tennessee. From this study, hydrology, water quality, and biological changes have been quantified and related to the types of mining and reclamation that are practical, the extent of watershed disturbed and the time since mining activity was completed. Since drainage in the study area was essentially non-acid in drainage characteristics, mining impacts aside from the more widely publicized acid mine drainage problem could be evaluated. Surface mining of steep slopes causes altered stream hydrology. There are increases in both peak storm water flow and dry weather flows. This is accompanied by long-term changes in water quality. Calcium, magnesium, manganese, iron, and sulfate levels are elevated. Increases in alkalinity and pH are probably caused more by clay formation and the solution chemistry of some elements than by presence of carbonate minerals. Of these changes, the major factors affecting biological characteristics of these streams are catastrophic storm flows and increased silt loading. Species diversity, richness and population densities were invariably reduced after mining. Presently used sediment-control measures do not mitigate these effects. The practical models for mining operation and the design of control structures which have been developed in this study show promise for wide application with suitable refinement.

Minear, R.A.; Tschantz, B.A.; Vaughan, G.L.

1983-06-01T23:59:59.000Z

196

Relationships between stripmining-induced changes and benthic insect communities in the southern Appalachian Region  

SciTech Connect (OSTI)

Increased demands for coal to supply America's energy needs, as well as the controversy surrounding the requirements and enforcement of the Surface Mining Control and Reclamation Act of 1977, point directly to the need for determination of specific factors associated with stripmining alteration that produce major environmental impacts. Numerous studies have demonstrated physical and chemical alterations to southern Appalachian streams subject to stripmining effluents found that the two major factors resulting in physical alterations were increased runoff and resultant sedimentation. Studies in streams receiving acid mine drainage showed that benthic insect communities differed in undisturbed and stripmining disturbed streams. Branson and Batch noted differences in benthic communities in Kentucky streams disturbed by non-acid stripmining. Tolbert found significant differences in benthic communities between undisturbed and nonacid mining streams. This paper describes research to determine what stripmining-altered parameters are responsible for differences in benthic insect communities. The results of this study can be applied toward validation of control measures required by the Surface Mining Control and Reclamation Act.

Tolbert, V.R.

1980-01-01T23:59:59.000Z

197

Analysis of close seam interaction problems in the Appalachian coal fields  

SciTech Connect (OSTI)

Mining into strata disturbed by previous mining operations either above or below may sometimes result in severe strata control problems. These interaction problems, associated with most multiple-seam mining operations, are very common in the Appalachian coal region and are the subject of this dissertation. On the basis of both theoretical and empirical analyses, using statistical analysis, numerical modeling, and photoelastic modeling methods in conjunction with the analysis of numerous case studies, a comprehensive, integrated model has been constructed and represented by a computer program called MSEAM. Using this comprehensive model, possible interaction problems under certain geological and mining conditions can be first predicted based on rules determined either empirically or statistically. Then, detailed analyses using different interaction mechanisms - pillar load transfer, arching effect, upper seam subsidence, innerburden bending, and innerburden shearing - can further determine the area or degree of possible interaction in both under- and over-mining situations. Special geologic and mining factors controlling interaction are also summarized by indices for an independent interaction prediction. This integrated model has been validated by back-analysis of several case studies. Full descriptions of multivariate statistical analysis, photoelastic modeling technique, quantization of various interaction mechanisms, and development of the comprehensive model are included.

Wu, W.

1987-01-01T23:59:59.000Z

198

Mortality in Appalachian coal mining regions: the value of statistical life lost  

SciTech Connect (OSTI)

We examined elevated mortality rates in Appalachian coal mining areas for 1979-2005, and estimated the corresponding value of statistical life (VSL) lost relative to the economic benefits of the coal mining industry. We compared age-adjusted mortality rates and socioeconomic conditions across four county groups: Appalachia with high levels of coal mining, Appalachia with lower mining levels, Appalachia without coal mining, and other counties in the nation. We converted mortality estimates to VSL estimates and compared the results with the economic contribution of coal mining. We also conducted a discount analysis to estimate current benefits relative to future mortality costs. The heaviest coal mining areas of Appalachia had the poorest socioeconomic conditions. Before adjusting for covariates, the number of excess annual age-adjusted deaths in coal mining areas ranged from 3,975 to 10,923, depending on years studied and comparison group. Corresponding VSL estimates ranged from $18.563 billion to $84.544 billion, with a point estimate of $50.010 billion, greater than the $8.088 billion economic contribution of coal mining. After adjusting for covariates, the number of excess annual deaths in mining areas ranged from 1,736 to 2,889, and VSL costs continued to exceed the benefits of mining. Discounting VSL costs into the future resulted in excess costs relative to benefits in seven of eight conditions, with a point estimate of $41.846 billion.

Hendryx, M.; Ahern, M.M. [West Virginia University, Morgantown, WV (United States). Dept. of Community Medicine

2009-07-15T23:59:59.000Z

199

Using Stochastic Roadmap Simulation to Predict Experimental Quantities in Protein Folding Kinetics: Folding Rates and  

E-Print Network [OSTI]

Using Stochastic Roadmap Simulation to Predict Experimental Quantities in Protein Folding Kinetics for studying protein folding kinetics. It uses the recently intro- duced Stochastic Roadmap Simulation (SRS validate the SRS method and indicate its potential as a general tool for studying protein folding kinetics

Pratt, Vaughan

200

Na-Cl-Br systematics of fluid inclusions from Mississippi Valley-type deposits, Appalachian Basin: Constraints on solute origin and migration paths  

SciTech Connect (OSTI)

This study evaluated Na-Cl-Br systematics of fluid inclusion-hosted brines in Mississippi Valley-type (MVT) deposits from the Appalachian Basin. Unlike other geochemical tracers such as lead and strontium isotopes which constrain metal sources, Na-Cl-Br systematics identify sources of brine salinity. Saline formation waters can vary systematically within and between basins with regard to their Na-Cl-Br compositions depending on the importance of halite dissolution relative to retention of subaerially evaporated seawater for the halogen budget. Oil field brine compositions from the Illinois and Appalachian basins are quite distinct in their Na-Cl-Br systematics. Compositions of saline fluid inclusions in MVT deposits generally are consistent with these regional differences. These results shed new light on the extent of regional flow systems and on the geochemical evolution of saline fluids responsible for mineralization. Nearly all fluid inclusions analyzed from the Appalachian MVT deposits have Na/Br and Cl/Br ratios less than modern seawater, consistent with ratios observed in marine brines involved in halite precipitation. The Na-Cl-Br systematics of the brines responsible for Appalachian MVT deposits may be inherited from original marine brines refluxed into the porous carbonate shelf sediments that host these deposits. The Cl/Br and Na/Br ratios of most fluid inclusion-hosted brines from Appalachian MVT sphalerites and fluorites fall into two compositional groups, one from the Lower Cambrian paleoaquifer and another from the Lower Ordovician paleoaquifer. Leachates from most MVT barite deposits form a third compositional group having lower Na/Br and Cl/Br ratios than the other two. Appalachian MVT leachate compositions differ significantly from those in MVT deposits in the Cincinnati arch-midcontinent region suggesting that these two MVT provinces formed from brines of different origin or flow path. 59 refs., 8 figs., 2 tabs.

Kesler, S.E.; Martini, A.M.; Appold, M.S.; Walter, L.M.; Huston, T.J. [Univ. of Michigan, Ann Arbor, MI (United States)] [Univ. of Michigan, Ann Arbor, MI (United States); Furman, F.C. [Univ. of Missouri, Rolla, MO (United States)] [Univ. of Missouri, Rolla, MO (United States)

1996-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "appalachian fold belt" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Corn Belt Energy Coop - Commercial Energy Efficiency Rebate Program  

Broader source: Energy.gov (indexed) [DOE]

Corn Belt Energy Coop - Commercial Energy Efficiency Rebate Program Corn Belt Energy Coop - Commercial Energy Efficiency Rebate Program (Illinois) Corn Belt Energy Coop - Commercial Energy Efficiency Rebate Program (Illinois) < Back Eligibility Agricultural Commercial Industrial Savings Category Other Heating & Cooling Commercial Heating & Cooling Cooling Heat Pumps Appliances & Electronics Commercial Lighting Lighting Maximum Rebate Custom Project: $0.06 per kWh reduced or 50% of project cost, up to $50,000 Program Info State Illinois Program Type Utility Rebate Program Rebate Amount Air Cooled Unitary Packaged AC/Split Systems: $60 - $75/ton Air Source Heat Pumps: $60 - $75/ton Geothermal Heat Pumps: $60 - $75/ton Packaged Terminal Heat Pump: $50/ton Room A/C: $20 Air Economizer: $150 - $180 Night Covers: $6 Programmable Thermostat: $20 - $25

202

Wheat Belt Public Power Dist | Open Energy Information  

Open Energy Info (EERE)

Belt Public Power Dist Belt Public Power Dist Jump to: navigation, search Name Wheat Belt Public Power Dist Place Nebraska Utility Id 20509 Utility Location Yes Ownership P NERC Location WECC/MRO NERC MRO Yes NERC WECC Yes Activity Transmission Yes Activity Distribution Yes References EIA Form EIA-861 Final Data File for 2010 - File1_a[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Utility Rate Schedules Grid-background.png DISTRIBUTION HEAVY INDUSTRIAL (E-2) Commercial GENERAL PURPOSE - LARGE COMMERCIAL Industrial GENERAL PURPOSE - LARGE COMMERCIAL Commercial GENERAL PURPOSE - SMALL Residential GENERAL PURPOSE - SMALL COMMERCIAL Commercial IRRIGATION Multi Phase Commercial LARGE POWER Industrial

203

Protein Folding as a Physical Stochastic Process  

E-Print Network [OSTI]

We model protein folding as a physical stochastic process as follows. The unfolded protein chain is treated as a random coil described by SAW (self-avoiding walk). Folding is induced by hydrophobic forces and other interactions, such as hydrogen bonding, which can be taken into account by imposing conditions on SAW. The resulting model is termed CSAW (conditioned self-avoiding walk. Conceptually, the mathematical basis is a generalized Langevin equation. In practice, the model is implemented on a computer by combining SAW and Monte Carlo. To illustrate the flexibility and capabilities of the model, we consider a number of examples, including folding pathways, elastic properties, helix formation, and collective modes.

Kerson Huang

2007-07-17T23:59:59.000Z

204

The Linkage between the Warm and the Cold Conveyor Belts in an Idealized Extratropical Cyclone  

Science Journals Connector (OSTI)

This study continues the investigation of airstreams in idealized moist baroclinic waves and addresses the formation of the cold conveyor belt (CCB), its linkage to the warm conveyor belt (WCB), and their impact on the development of a midlatitude ...

Sebastian Schemm; Heini Wernli

2014-04-01T23:59:59.000Z

205

E-Print Network 3.0 - allen radiation belt Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

ALBEDO OF SMALL SOLAR SYSTEM BODIES. I. V. Moskalenko1,2 , T. A. Porter3 Summary: and ice in Main Belt asteroids and Kuiper Belt objects (KBOs) using the Moon as a template. We...

206

Mutagenic effects on protein folding and stability  

E-Print Network [OSTI]

Knowing how sequence information dictates the formation of protein structure is critical for accurate prediction of structure, for de novo protein design, and for understanding protein folding and misfolding. Based on ...

Anderson, Thomas Anthony, 1973-

2002-01-01T23:59:59.000Z

207

Cooperativity and Contact Order in Protein Folding  

E-Print Network [OSTI]

The effects of cooperativity are studied within Go-Lennard-Jones models of proteins by making the contact interactions dependent on the proximity to the native conformation. The kinetic universality classes are found to remain the same as in the absence of cooperativity. For a fixed native geometry, small changes in the effective contact map may affect the folding times in a chance way and to the extent that is comparable to the shift in the folding times due to cooperativity. The contact order controlls folding scenarios: the average times necessary to bring pairs of amino acids into their near native separations depend on the sequential distances within the pairs. This dependence is largely monotonic, regardless of the cooperativity, and the dominant trend could be described by a single parameter like the average contact order. However, it is the deviations from the trend which are usually found to set the net folding times.

Marek Cieplak

2004-01-11T23:59:59.000Z

208

Cooperativity and contact order in protein folding  

Science Journals Connector (OSTI)

The effects of cooperativity are studied within Go-Lennard-Jones models of proteins by making the contact interactions dependent on the proximity to the native conformation. The kinetic universality classes are found to remain the same as in the absence of cooperativity. For a fixed native geometry, small changes in the effective contact map may affect the folding times in a chance way, and, to an extent that is comparable to the shift in the folding times due to cooperativity. The contact order controls folding scenarios: the average times necessary to bring pairs of amino acids into their near native separations depend on the sequential distances within the pairs. This dependence is largely monotonic, regardless of the cooperativity, and the dominant trend could be described by a single parameter like the average contact order. However, it is the deviations from the trend which are usually found to set the net folding times.

Marek Cieplak

2004-03-23T23:59:59.000Z

209

Enhanced sampling and applications in protein folding.  

E-Print Network [OSTI]

??We show that a single-copy tempering method is useful in protein-folding simulations of large scale and high accuracy (explicit solvent, atomic representation, and physics-based potential).… (more)

Zhang, Cheng

2013-01-01T23:59:59.000Z

210

A phenomenological model of protein folding  

E-Print Network [OSTI]

We construct a phenomenological effective field theory model that describes the universality class of biologically active single-strand proteins. The model allows both for an explicit construction of native state protein conformations, and a dynamical description of protein folding and unfolding processes. The model reveals a connection between homochirality and protein collapse, and enables the theoretical investigation of various other aspects of protein folding even in the case of very long polypeptide chains where other methods are not available.

Danielsson, Ulf H; Niemi, Antti J

2009-01-01T23:59:59.000Z

211

A parametric study of the source rate for outer radiation belt electrons using a Kalman filter  

E-Print Network [OSTI]

A parametric study of the source rate for outer radiation belt electrons using a Kalman filter Q), A parametric study of the source rate for outer radiation belt electrons using a Kalman filter, J. Geophys. Res increasingly popular to describe the outer radiation belt energetic electron environment. We use a Kalman

Li, Xinlin

212

Toward a Theory on the Stability of Protein Folding: Challenges for Folding Models  

E-Print Network [OSTI]

We adopt the point of view that analysis of the stability of the protein folding process is central to understanding the underlying physics of folding. Stability of the folding process means that many perturbations do not disrupt the progress from the random coil to the native state. In this paper we explore the stability of folding using established methods from physics and mathematics. Our result is a preliminary theory of the physics of folding. We suggest some tests of these ideas using folding simulations. We begin by supposing that folding events are related in some way to mechanical waves on the molecule. We adopt an analytical approach to the physics which was pioneered by M.V. Berry, (in another context), based upon mathematics developed mainly by R. Thom and V.I. Arnold. We find that the stability of the folding process can be understood in terms of structures known as caustics, which occur in many kinds of wave phenomena. The picture that emerges is that natural selection has given us a set of protein molecules which have mechanical waves that propagate according to several mathematically specific restrictions. Successful simulations of folding can be used to test and constrain these wave motions. With some additional assumptions the theory explains or is consistent with a number of experimental facts about folding. We emphasize that this wave-based approach is fundamentally different from energy-based approaches.

Walter Simmons; Joel L. Weiner

2011-12-28T23:59:59.000Z

213

Review Protein Folding and Misfolding on Surfaces  

E-Print Network [OSTI]

Abstract: Protein folding, misfolding and aggregation, as well as the way misfolded and aggregated proteins affects cell viability are emerging as key themes in molecular and structural biology and in molecular medicine. Recent advances in the knowledge of the biophysical basis of protein folding have led to propose the energy landscape theory which provides a consistent framework to better understand how a protein folds rapidly and efficiently to the compact, biologically active structure. The increased knowledge on protein folding has highlighted its strict relation to protein misfolding and aggregation, either process being in close competition with the other, both relying on the same physicochemical basis. The theory has also provided information to better understand the structural and environmental factors affecting protein folding resulting in protein misfolding and aggregation into ordered or disordered polymeric assemblies. Among these, particular importance is given to the effects of surfaces. The latter, in some cases make possible rapid and efficient protein folding but most often recruit proteins/peptides increasing their local concentration thus favouring misfolding and accelerating the rate of nucleation. It is also emerging that surfaces can modify the path of protein misfolding and aggregation generating oligomers and polymers structurally different from those arising in the bulk solution and endowed with different physical properties and cytotoxicities.

Massimo Stefani

2008-01-01T23:59:59.000Z

214

Protein Folding: A Perspective From Statistical Physics  

E-Print Network [OSTI]

In this paper, we introduce an approach to the protein folding problem from the point of view of statistical physics. Protein folding is a stochastic process by which a polypeptide folds into its characteristic and functional 3D structure from random coil. The process involves an intricate interplay between global geometry and local structure, and each protein seems to present special problems. We introduce CSAW (conditioned self-avoiding walk), a model of protein folding that combines the features of self-avoiding walk (SAW) and the Monte Carlo method. In this model, the unfolded protein chain is treated as a random coil described by SAW. Folding is induced by hydrophobic forces and other interactions, such as hydrogen bonding, which can be taken into account by imposing conditions on SAW. Conceptually, the mathematical basis is a generalized Langevin equation. To illustrate the flexibility and capabilities of the model, we consider several examples, including helix formation, elastic properties, and the transition in the folding of myoglobin. From the CSAW simulation and physical arguments, we find a universal elastic energy for proteins, which depends only on the radius of gyration $R_{g}$ and the residue number $N$. The elastic energy gives rise to scaling laws $R_{g}\\sim N^{\

Jinzhi Lei; Kerson Huang

2010-02-26T23:59:59.000Z

215

Hierarchical Protein Folding Pathways: A Computational Study of Protein Fragments  

E-Print Network [OSTI]

Hierarchical Protein Folding Pathways: A Computational Study of Protein Fragments Nurit Haspel,1 folding model. The model postulates that protein folding is a hierarchical top-down pro- cess. The basic words: protein folding; building blocks; pro- tein structure prediction; hierarchical folding; protein

Haspel, Nurit

216

DYNAMIC INVARIANTS IN PROTEIN FOLDING PATHWAYS REVEALED BY TENSOR ANALYSIS  

E-Print Network [OSTI]

DYNAMIC INVARIANTS IN PROTEIN FOLDING PATHWAYS REVEALED BY TENSOR ANALYSIS Arvind Ramanathan Lane a spatio-temporal analysis of protein folding pathways. We applied our method to folding simulations of how a protein folds into its functionally relevant conformations. Protein folding pathways span over

Langmead, Christopher James

217

FROM GENETIC CODING TO PROTEIN FOLDING Jean-Luc Jestin  

E-Print Network [OSTI]

FROM GENETIC CODING TO PROTEIN FOLDING Jean-Luc Jestin ABSTRACT A discrete classical mechanics (DCM of the genetic code. A DCM model for protein folding allows a set of folding nuclei to be derived for each. A PROTEIN FOLDING MODEL Let us consider the following protein folding model. A chemical group of mass m

Paris-Sud XI, Université de

218

Predicting Protein Folding Mohammed J. Zaki, Vinay Nadimpally, Deb  

E-Print Network [OSTI]

Predicting Protein Folding Pathways Mohammed J. Zaki, Vinay Nadimpally, Deb Bardhan, Chris Bystroff 1. Predicting Protein Folding Pathways Summary. A structured folding pathway, which is a time ordered sequence of folding events, plays an important role in the protein folding process and hence

Zaki, Mohammed Javeed

219

Data Analysis of Villin Headpiece Subdomain Folding Simulations.  

E-Print Network [OSTI]

seeks to understand the process of protein folding by analyzing the vast amount of data generated while simulating the folding of the villin headpiece. Introduction Protein folding has been called one proteins unlike homology or threading based approaches. Protein folding studies the folding trajectory

220

Effective Conveyor Belt Inspection for Improved Mining Productivity  

SciTech Connect (OSTI)

This document details progress on the project entitled ''Effective Conveyor Belt Inspection for Improved Mining Productivity'' during the period from November 15, 2004 to May 14, 2004. Highlights include fabrication of an improved LED lightbar, fabrication of a line-scan sensor head for the Smart-Camera based prototype, and development of prototype vulcanized splice detection algorithms.

Chris Fromme

2006-06-01T23:59:59.000Z

Note: This page contains sample records for the topic "appalachian fold belt" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Solar heating of swimming pools for the subtropical coastal belt  

SciTech Connect (OSTI)

Consideration is given to heating a swimming pool to obtain all-year-round use or alternatively to extend the use of the pool into the winter period. The report has been prepared for Durban and other parts of the subtropical Coastal Belt as a guide for advising those who may consider using solar energy for such an undertaking.

Forbes, J.; Dobson, D.E.

1980-01-01T23:59:59.000Z

222

POPULATION OF THE SCATTERED KUIPER BELT 1 Chadwick A. Trujillo  

E-Print Network [OSTI]

collected at Canada­France­Hawaii Telescope, which is operated by the National Research Council of Canada Belt, Oort Cloud --- solar system: formation #12; -- 3 -- 1. Introduction The outer solar system the formation era of the solar system and are composed of the oldest, least­modified materials in our solar

Jewitt, David C.

223

"1. John E Amos","Coal","Appalachian Power Co",2900 "2. Harrison Power Station","Coal","Allegheny Energy Supply Co LLC",1954  

U.S. Energy Information Administration (EIA) Indexed Site

West Virginia" West Virginia" "1. John E Amos","Coal","Appalachian Power Co",2900 "2. Harrison Power Station","Coal","Allegheny Energy Supply Co LLC",1954 "3. Mt Storm","Coal","Virginia Electric & Power Co",1571 "4. Mitchell","Coal","Ohio Power Co",1560 "5. Mountaineer","Coal","Appalachian Power Co",1310 "6. Pleasants Power Station","Coal","Allegheny Energy Supply Co LLC",1288 "7. Fort Martin Power Station","Coal","Monongahela Power Co",1107 "8. Philip Sporn","Coal","Appalachian Power Co",1020 "9. Kammer","Coal","Ohio Power Co",600

224

Flexible electrode belt for EIT using nanofiber web dry electrodes  

Science Journals Connector (OSTI)

Efficient connection of multiple electrodes to the body for impedance measurement and voltage monitoring applications is of critical importance to measurement quality and practicality. Electrical impedance tomography (EIT) experiments have generally required a cumbersome procedure to attach the multiple electrodes needed in EIT. Once placed, these electrodes must then maintain good contact with the skin during measurements that may last several hours. There is usually also the need to manage the wires that run between the electrodes and the EIT system. These problems become more severe as the number of electrodes increases, and may limit the practicality and portability of this imaging method. There have been several trials describing human–electrode interfaces using configurations such as electrode belts, helmets or rings. In this paper, we describe an electrode belt we developed for long-term EIT monitoring of human lung ventilation. The belt included 16 embossed electrodes that were designed to make good contact with the skin. The electrodes were fabricated using an Ag-plated PVDF nanofiber web and metallic threads. A large contact area and padding were used behind each electrode to improve subject comfort and reduce contact impedances. The electrodes were incorporated, equally spaced, into an elasticated fabric belt. We tested the electrode belt in conjunction with the KHU Mark1 multi-frequency EIT system, and demonstrate time-difference images of phantoms and human subjects during normal breathing and running. We found that the Ag-plated PVDF nanofiber web electrodes were suitable for long-term measurement because of their flexibility and durability. Moreover, the contact impedance and stability of the Ag-plated PVDF nanofiber web electrodes were found to be comparable to similarly tested Ag/AgCl electrodes.

Tong In Oh; Tae Eui Kim; Sun Yoon; Kap Jin Kim; Eung Je Woo; Rosalind J Sadleir

2012-01-01T23:59:59.000Z

225

Strontium isotope quantification of siderite, brine and acid mine drainage contributions to abandoned gas well discharges in the Appalachian Plateau  

SciTech Connect (OSTI)

Unplugged abandoned oil and gas wells in the Appalachian region can serve as conduits for the movement of waters impacted by fossil fuel extraction. Strontium isotope and geochemical analysis indicate that artesian discharges of water with high total dissolved solids (TDS) from a series of gas wells in western Pennsylvania result from the infiltration of acidic, low Fe (Fe < 10 mg/L) coal mine drainage (AMD) into shallow, siderite (iron carbonate)-cemented sandstone aquifers. The acidity from the AMD promotes dissolution of the carbonate, and metal- and sulfate-contaminated waters rise to the surface through compromised abandoned gas well casings. Strontium isotope mixing models suggest that neither upward migration of oil and gas brines from Devonian reservoirs associated with the wells nor dissolution of abundant nodular siderite present in the mine spoil through which recharge water percolates contribute significantly to the artesian gas well discharges. Natural Sr isotope composition can be a sensitive tool in the characterization of complex groundwater interactions and can be used to distinguish between inputs from deep and shallow contamination sources, as well as between groundwater and mineralogically similar but stratigraphically distinct rock units. This is of particular relevance to regions such as the Appalachian Basin, where a legacy of coal, oil and gas exploration is coupled with ongoing and future natural gas drilling into deep reservoirs.

Chapman, Elizabeth C.; Capo, Rosemary C.; Stewart, Brian W.; Hedin, Robert S.; Weaver, Theodore J.; Edenborn, Harry M.

2013-04-01T23:59:59.000Z

226

Solvent-induced forces in protein folding reflections on the protein folding problem  

Science Journals Connector (OSTI)

Abstract It is shown that the solvent induced forces on hydrophilic groups are the strongest ones. The relevance of this finding to protein folding is discussed.

Arieh Ben-Naim

2013-01-01T23:59:59.000Z

227

Exploring zipping and assembly as a protein folding principle  

E-Print Network [OSTI]

C. Are there pathways for protein folding? Journal de Chimieand the mechanism of protein folding. Ann Rev Biochem 1982;Baldwin RL. How does protein folding get started? TRENDS in

Voelz, Vince A; Dill, Ken A

2007-01-01T23:59:59.000Z

228

Protein folding using contact maps Michele Vendruscolo and Eytan Domany  

E-Print Network [OSTI]

Protein folding using contact maps Michele Vendruscolo and Eytan Domany Department of Physics 26 I. INTRODUCTION Computational approaches to protein folding are divided into two main categories protein fold prediction. Contact maps are a particularly manageable representation of protein structure

Domany, Eytan

229

THE UNIVERSITY OF CHICAGO CHARACTERIZATION OF PROTEIN FOLDING INTERMEDIATES  

E-Print Network [OSTI]

THE UNIVERSITY OF CHICAGO CHARACTERIZATION OF PROTEIN FOLDING INTERMEDIATES FOR DELINEATION ............................................................................................................ 1 1.1 Why study protein folding .............................................................................. 3 1.2.1 How fast should a protein fold ........................................................... 3

Sosnick, Tobin R.

230

Increasing Stability Reduces Conformational Heterogeneity in a Protein Folding  

E-Print Network [OSTI]

Increasing Stability Reduces Conformational Heterogeneity in a Protein Folding Intermediate, the results show that protein folding intermediates are ensembles of different structural forms direct experi- mental evidence in support of a basic tenet of energy landscape theory for protein folding

231

Break the Green Belt? The differences between green belt and its alternative green wedge: A comparative study of London and Stockholm.  

E-Print Network [OSTI]

??The paper sets out to compare two widely applied planning strategies – green belt and green wedge – to understand if as an alternative, the green wedge… (more)

Kong, Luyao

2012-01-01T23:59:59.000Z

232

Protein Folding: A New Geometric Analysis  

E-Print Network [OSTI]

A geometric analysis of protein folding, which complements many of the models in the literature, is presented. We examine the process from unfolded strand to the point where the strand becomes self-interacting. A central question is how it is possible that so many initial configurations proceed to fold to a unique final configuration. We put energy and dynamical considerations temporarily aside and focus upon the geometry alone. We parameterize the structure of an idealized protein using the concept of a ribbon from differential geometry. The deformation of the ribbon is described by introducing a generic twisting Ansatz. The folding process in this picture entails a change in shape guided by the local amino acid geometry. The theory is reparamaterization invariant from the start, so the final shape is independent of folding time. We develop differential equations for the changing shape. For some parameter ranges, a sine-Gordon torsion soliton is found. This purely geometric waveform has properties similar to dynamical solitons. Namely: A threshold distortion of the molecule is required to initiate the soliton, after which, small additional distortions do not change the waveform. In this analysis, the soliton twists the molecule until bonds form. The analysis reveals a quantitative relationship between the geometry of the amino acids and the folded form.

Walter A. Simmons; Joel L. Weiner

2008-09-11T23:59:59.000Z

233

Isolation, folding and structural investigations of the amino...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

folding and structural investigations of the amino acid transporter OEP16. Isolation, folding and structural investigations of the amino acid transporter OEP16. Abstract: Membrane...

234

Single-Molecule Dynamics Reveals Cooperative Binding-Folding...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Molecule Dynamics Reveals Cooperative Binding-Folding in Protein Recognition . Single-Molecule Dynamics Reveals Cooperative Binding-Folding in Protein Recognition . Abstract: The...

235

Journal Article: Folding and association of a homotetrameric...  

Office of Scientific and Technical Information (OSTI)

Folding and association of a homotetrameric protein complex in an all-atom Go model Citation Details Title: Folding and association of a homotetrameric protein complex in an...

236

Protein Folding Pathways Implementing Dihedral Angle Variable Speed  

Science Journals Connector (OSTI)

Protein folding remains as an impossible riddle biologist must ... requirements make it difficult to obtain clues regarding protein folding nature. The procedure presented in this paper...

Mikel Diez; Victor Petuya; Mónica Urizar…

2012-01-01T23:59:59.000Z

237

Topologies to geometries in protein folding: Hierarchical and nonhierarchical scenarios  

E-Print Network [OSTI]

Topologies to geometries in protein folding: Hierarchical and nonhierarchical scenarios Ariel Ferna presents a method to portray protein folding dynamics at a coarse resolution, based on a pattern

Berry, R. Stephen

238

Coarse grained description of protein folding  

Science Journals Connector (OSTI)

We consider two- and three-dimensional lattice models of proteins that were characterized previously. We coarse grain their folding dynamics by reducing it to transitions between effective states. We consider two methods of selection of the effective states. The first method is based on the steepest descent mapping of states to underlying local energy minima and the other involves an additional projection to maximally compact conformations. Both methods generate connectivity patterns that allow one to distinguish between the good and bad folders. Connectivity graphs corresponding to the folding funnel have few loops and are thus treelike. The Arrhenius law for the median folding time of a 16-monomer sequence is established and the corresponding barrier is related to easily identifiable kinetic trap states.

Marek Cieplak and Trinh Xuan Hoang

1998-09-01T23:59:59.000Z

239

Exploring the mechanisms of protein folding  

E-Print Network [OSTI]

Neither of the two prevalent theories, namely thermodynamic stability and kinetic stability, provides a comprehensive understanding of protein folding. The thermodynamic theory is misleading because it assumes that free energy is the exclusive dominant mechanism of protein folding, and attributes the structural transition from one characteristic state to another to energy barriers. Conversely, the concept of kinetic stability overemphasizes dominant mechanisms that are related to kinetic factors. This article explores the stability condition of protein structures from the viewpoint of meso-science, paying attention to the compromise in the competition between minimum free energy and other dominant mechanisms. Based on our study of complex systems, we propose that protein folding is a meso-scale, dissipative, nonlinear and non-equilibrium process that is dominated by the compromise between free energy and other dominant mechanisms such as environmental factors. Consequently, a protein shows dynamic structures,...

Xu, Ji; Ren, Ying; Li, Jinghai

2013-01-01T23:59:59.000Z

240

Toward a Theory on the Stability of Protein Folding: Challenges for Folding Models  

E-Print Network [OSTI]

We adopt the point of view that analysis of the stability of the protein folding process is central to understanding the underlying physics of folding. Stability of the folding process means that many perturbations do not disrupt the progress from the random coil to the native state. In this paper we explore the stability of folding using established methods from physics and mathematics. Our result is a preliminary theory of the physics of folding. We suggest some tests of these ideas using folding simulations. We begin by supposing that folding events are related in some way to mechanical waves on the molecule. We adopt an analytical approach to the physics which was pioneered by M.V. Berry, (in another context), based upon mathematics developed mainly by R. Thom and V.I. Arnold. We find that the stability of the folding process can be understood in terms of structures known as caustics, which occur in many kinds of wave phenomena. The picture that emerges is that natural selection has given us a set of prot...

Simmons, Walter

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "appalachian fold belt" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Energetic Components of Cooperative Protein Folding  

E-Print Network [OSTI]

A new lattice protein model with a four-helix bundle ground state is analyzed by a parameter-space Monte Carlo histogram technique to evaluate the effects of an extensive variety of model potentials on folding thermodynamics. Cooperative helical formation and contact energies based on a 5-letter alphabet are found to be insufficient to satisfy calorimetric and other experimental criteria for two-state folding. Such proteinlike behaviors are predicted, however, by models with polypeptide-like local conformational restrictions and environment-dependent hydrogen bonding-like interactions.

Huseyin Kaya; Hue Sun Chan

2000-10-11T23:59:59.000Z

242

Protein Folding in Contact Map Space  

Science Journals Connector (OSTI)

Changing a few contacts in a contact map corresponds to a large scale move in confrontation space; hence, one gains a lot by using the contact map representation for protein folding. We developed an efficient search procedure in the space of physical contact maps, which could identify the native fold as of the lowest free energy, provided on had a free energy function whose ground state is the native map. We prove rigorously that the widely used pairwise contact approximation to the free energy cannot stabilize even a single protein's native map. Testing the native map against a set of decoys obtained by gapless threading, one may be misled to the opposite conclusion.

M. Vendruscolo; R. Najmanovich; E. Domany

1999-01-18T23:59:59.000Z

243

Energetic Components of Cooperative Protein Folding  

Science Journals Connector (OSTI)

A new lattice protein model with a four-helix bundle ground state is analyzed by a parameter-space Monte Carlo histogram technique to evaluate the effects of an extensive variety of model potentials on folding thermodynamics. Cooperative helical formation and contact energies based on a 5-letter alphabet are found to be insufficient to satisfy calorimetric and other experimental criteria for two-state folding. Such proteinlike behaviors are predicted, however, by models with polypeptidelike local conformational restrictions and environment-dependent hydrogen-bondinglike interactions.

Hüseyin Kaya and Hue Sun Chan

2000-11-27T23:59:59.000Z

244

Circular permutant GFP insertion folding reporters  

SciTech Connect (OSTI)

Provided are methods of assaying and improving protein folding using circular permutants of fluorescent proteins, including circular permutants of GFP variants and combinations thereof. The invention further provides various nucleic acid molecules and vectors incorporating such nucleic acid molecules, comprising polynucleotides encoding fluorescent protein circular permutants derived from superfolder GFP, which polynucleotides include an internal cloning site into which a heterologous polynucleotide may be inserted in-frame with the circular permutant coding sequence, and which when expressed are capable of reporting on the degree to which a polypeptide encoded by such an inserted heterologous polynucleotide is correctly folded by correlation with the degree of fluorescence exhibited.

Waldo, Geoffrey S. (Santa Fe, NM); Cabantous, Stephanie (Los Alamos, NM)

2011-06-14T23:59:59.000Z

245

Circular permutant GFP insertion folding reporters  

SciTech Connect (OSTI)

Provided are methods of assaying and improving protein folding using circular permutants of fluorescent proteins, including circular permutants of GFP variants and combinations thereof. The invention further provides various nucleic acid molecules and vectors incorporating such nucleic acid molecules, comprising polynucleotides encoding fluorescent protein circular permutants derived from superfolder GFP, which polynucleotides include an internal cloning site into which a heterologous polynucleotide may be inserted in-frame with the circular permutant coding sequence, and which when expressed are capable of reporting on the degree to which a polypeptide encoded by such an inserted heterologous polynucleotide is correctly folded by correlation with the degree of fluorescence exhibited.

Waldo, Geoffrey S. (Santa Fe, NM); Cabantous, Stephanie (Los Alamos, NM)

2008-06-24T23:59:59.000Z

246

Circular permutant GFP insertion folding reporters  

DOE Patents [OSTI]

Provided are methods of assaying and improving protein folding using circular permutants of fluorescent proteins, including circular permutants of GFP variants and combinations thereof. The invention further provides various nucleic acid molecules and vectors incorporating such nucleic acid molecules, comprising polynucleotides encoding fluorescent protein circular permutants derived from superfolder GFP, which polynucleotides include an internal cloning site into which a heterologous polynucleotide may be inserted in-frame with the circular permutant coding sequence, and which when expressed are capable of reporting on the degree to which a polypeptide encoded by such an inserted heterologous polynucleotide is correctly folded by correlation with the degree of fluorescence exhibited.

Waldo, Geoffrey S.; Cabantous, Stephanie

2013-04-16T23:59:59.000Z

247

Nonlinear conformation of secondary protein folding  

E-Print Network [OSTI]

A model to describe the mechanism of conformational dynamics in secondary protein based on matter interactions is proposed. The approach deploys the lagrangian method by imposing certain symmetry breaking. The protein backbone is initially assumed to be nonlinear and represented by the Sine-Gordon equation, while the nonlinear external bosonic sources is represented by $\\phi^4$ interaction. It is argued that the nonlinear source induces the folding pathway in a different way than the previous work with initially linear backbone. Also, the nonlinearity of protein backbone decreases the folding speed.

Januar, M; Handoko, L T

2012-01-01T23:59:59.000Z

248

CSAW: a dynamical model of protein folding  

E-Print Network [OSTI]

CSAW (conditioned self-avoiding walk) is a model of protein folding that combines SAW (self-avoiding walk) with Monte-Carlo. It simulates the Brownian motion of a chain molecule in the presence of interactions, both among chain residues, and with the environment. In a first model that includes the hydrophobic effect and hydrogen bonding, a chain of 30 residues folds into a native state with stable secondary and tertiary structures. The process starts with a rapid collapse into an intermediate "molten globule", which slowly decays into the native state afer a relatively long quiescent period. The behavior of the radius of gyration mimics experimental data.

Kerson Huang

2006-01-12T23:59:59.000Z

249

Circular permutant GFP insertion folding reporters  

SciTech Connect (OSTI)

Provided are methods of assaying and improving protein folding using circular permutants of fluorescent proteins, including circular permutants of GFP variants and combinations thereof. The invention further provides various nucleic acid molecules and vectors incorporating such nucleic acid molecules, comprising polynucleotides encoding fluorescent protein circular permutants derived from superfolder GFP, which polynucleotides include an internal cloning site into which a heterologous polynucleotide may be inserted in-frame with the circular permutant coding sequence, and which when expressed are capable of reporting on the degree to which a polypeptide encoded by such an inserted heterologous polynucleotide is correctly folded by correlation with the degree of fluorescence exhibited.

Waldo, Geoffrey S; Cabantous, Stephanie

2013-02-12T23:59:59.000Z

250

On the 'Scattered' Inclinations in the Kuiper Belt  

E-Print Network [OSTI]

This paper shows that the inclinations of bodies captured into mean motion resonances in the Kuiper belt have remained very nearly unchanged, being only slightly increased from initial lower values by migration and/or by long-term planetary perturbations. Thus the observed maximum as high as ~ 30 deg of the i's of bodies in resonance must reflect either a broad initial range at least to that level for capturable bodies or an elevating process possibly exemplified by the sweeping of secular resonances. We have obtained capture probabilities for 2 well-populated resonances, showing reduced but finite values for i's up to 35 deg. Whatever led to the present distribution must have produced increases in i for some, but not for all, resonant bodies in the belt.

Franklin, Fred

2015-01-01T23:59:59.000Z

251

SECONDARY NATURAL GAS RECOVERY IN THE APPALACHIAN BASIN: APPLICATION OF ADVANCED TECHNOLOGIES IN A FIELD DEMONSTRATION SITE, HENDERSON DOME, WESTERN PENNSYLVANIA  

SciTech Connect (OSTI)

The principal objectives of this project were to test and evaluate technologies that would result in improved characterization of fractured natural-gas reservoirs in the Appalachian Basin. The Bureau of Economic Geology (Bureau) worked jointly with industry partner Atlas Resources, Inc. to design, execute, and evaluate several experimental tests toward this end. The experimental tests were of two types: (1) tests leading to a low-cost methodology whereby small-scale microfractures observed in matrix grains of sidewall cores can be used to deduce critical properties of large-scale fractures that control natural-gas production and (2) tests that verify methods whereby robust seismic shear (S) waves can be generated to detect and map fractured reservoir facies. The grain-scale microfracture approach to characterizing rock facies was developed in an ongoing Bureau research program that started before this Appalachian Basin study began. However, the method had not been tested in a wide variety of fracture systems, and the tectonic setting of rocks in the Appalachian Basin composed an ideal laboratory for perfecting the methodology. As a result of this Appalachian study, a low-cost commercial procedure now exists that will allow Appalachian operators to use scanning electron microscope (SEM) images of thin sections extracted from oriented sidewall cores to infer the spatial orientation, relative geologic timing, and population density of large-scale fracture systems in reservoir sandstones. These attributes are difficult to assess using conventional techniques. In the Henderson Dome area, large quartz-lined regional fractures having N20E strikes, and a subsidiary set of fractures having N70W strikes, are prevalent. An innovative method was also developed for obtaining the stratigraphic and geographic tops of sidewall cores. With currently deployed sidewall coring devices, no markings from which top orientation can be obtained are made on the sidewall core itself during drilling. The method developed in this study involves analysis of the surface morphology of the broken end of the core as a top indicator. Together with information on the working of the tool (rotation direction), fracture-surface features, such as arrest lines and plume structures, not only give a top direction for the cores but also indicate the direction of fracture propagation in the tough, fine-grained Cataract/Medina sandstones. The study determined that microresistivity logs or other image logs can be used to obtain accurate sidewall core azimuths and to determine the precise depths of the sidewall cores. Two seismic S-wave technologies were developed in this study. The first was a special explosive package that, when detonated in a conventional seismic shot hole, produces more robust S-waves than do standard seismic explosives. The importance of this source development is that it allows S-wave seismic data to be generated across all of the Appalachian Basin. Previously, Appalachian operators have not been able to use S-wave seismic technology to detect fractured reservoirs because the industry-standard S-wave energy source, the horizontal vibrator, is not a practical source option in the heavy timber cover that extends across most of the basin. The second S-wave seismic technology that was investigated was used to verify that standard P-wave seismic sources can create robust downgoing S-waves by P-to-S mode conversion in the shallow stratigraphic layering in the Appalachian Basin. This verification was done by recording and analyzing a 3-component vertical seismic profile (VSP) in the Atlas Montgomery No. 4 well at Henderson Dome, Mercer County, Pennsylvania. The VSP data confirmed that robust S-waves are generated by P-to-S mode conversion at the basinwide Onondaga stratigraphic level. Appalachian operators can thus use converted-mode seismic technology to create S-wave images of fractured and unfractured rock systems throughout the basin.

BOB A. HARDAGE; ELOISE DOHERTY; STEPHEN E. LAUBACH; TUCKER F. HENTZ

1998-08-14T23:59:59.000Z

252

Algorithmic design of self-folding polyhedra  

Science Journals Connector (OSTI)

...chosen according to an algorithm described below. Fifty samples of each net were self-folded in the experiments. We used Autodesk AutoCAD to draw nets and then printed them on transparent sheets to make photomasks. Sides of a panel measured 300 {mu...

Shivendra Pandey; Margaret Ewing; Andrew Kunas; Nghi Nguyen; David H. Gracias; Govind Menon

2011-01-01T23:59:59.000Z

253

Simultaneous Alignment and Folding of Protein Sequences  

E-Print Network [OSTI]

is to predict for every input sequence the minimum free-energy non-crossing structure (in O(n3 ) time function. Since the structure of RNA is evolu- tionarily more conserved than its sequence, predicting a folding with minimal free energy [5, 6, 7, 8, 9]. Albeit this so-named thermodynamic approach is a success

Gifford, David K.

254

Critical aspects of hierarchical protein folding  

E-Print Network [OSTI]

We argue that the first order folding transitions of proteins observed at physiological chemical conditions end in a critical point for a given temperature and chemical potential of the surrounding water. We investigate this critical point using a hierarchical Hamiltonian and determine its universality class. This class differs qualitatively from those of other known models.

Alex Hansen; Mogens H. Jensen; Kim Sneppen; Giovanni Zocchi

1998-01-13T23:59:59.000Z

255

Solvent-induced forces in protein folding  

SciTech Connect (OSTI)

The solvent-induced forces between various groups on the protein are examined. It is found that the intramolecular hydrophilic forces are likely to be the strongest forces mediated through the solvent. It is argued that these are probably the most important solvent-induced driving forces in the process of protein folding.

Ben-Naim, A. (Hebrew Univ., Jerusalem (Israel))

1990-08-23T23:59:59.000Z

256

Folded-path optical analysis gas cell  

DOE Patents [OSTI]

A folded-path gas cell employs an elliptical concave mirror in confronting relationship to two substantially spherical concave mirrors. At least one of the spherical mirrors, and usually both, are formed with an added cylindrical component to increase orthogonal focii coincidence and thereby to increase the radiation energy throughput characteristic of the cell.

Carangelo, Robert M. (Glastonbury, CT); Wright, David D. (Vershire, VT)

1995-01-01T23:59:59.000Z

257

Optimization of a Microfluidic Mixer for Studying Protein Folding Kinetics  

E-Print Network [OSTI]

Optimization of a Microfluidic Mixer for Studying Protein Folding Kinetics David E. Hertzog with numerical simulations to minimize the mixing time of a microfluidic mixer developed for protein folding reported continuous flow mixer for protein folding. Fast events in protein folding often occur

Santiago, Juan G.

258

Early Events in Protein Folding Explored by Rapid Mixing Methods  

E-Print Network [OSTI]

15 Early Events in Protein Folding Explored by Rapid Mixing Methods Heinrich Roder, Kosuke Maki for Understanding Protein Folding As with any complex reaction, time-resolved data are essential for elucidating the mechanism of protein folding. Even in cases where the whole process of folding occurs in a single step

Roder, Heinrich

259

COMMUNICATION First Principles Prediction of Protein Folding Rates  

E-Print Network [OSTI]

COMMUNICATION First Principles Prediction of Protein Folding Rates Derek A. Debe and William A studies have demonstrated that many small, single-domain proteins fold via simple two-state kinetics. We. # 1999 Academic Press Keywords: protein folding; kinetics; diffusion; fold topology; nucleation

Goddard III, William A.

260

Cellular mechanisms of membrane protein folding William R Skach  

E-Print Network [OSTI]

Cellular mechanisms of membrane protein folding William R Skach The membrane protein­folding. This Perspective will focus on emerging evidence that the RTC functions as a protein-folding machine that restricts. The process of polytopic (multispanning) membrane protein folding can be viewed as a series of sequential

Cai, Long

Note: This page contains sample records for the topic "appalachian fold belt" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Nonlinear dynamics of secondary protein folding Natalia G. Berloff  

E-Print Network [OSTI]

Nonlinear dynamics of secondary protein folding Natalia G. Berloff Department of Applied field varies. Pacs: 87.15.-v, 87.15By, 05.45.-a, 41.20Jb Keywords: Folding pathway, protein folding interaction and hydrophobic effects. The most common shapes of the protein folding are alpha () and beta

262

Protein folding by zipping and assembly S. Banu Ozkan*  

E-Print Network [OSTI]

Protein folding by zipping and assembly S. Banu Ozkan* , G. Albert Wu* , John D. Chodera, CA, May 2, 2007 (received for review April 13, 2006) How do proteins fold so quickly? Some denatured proteins fold to their native structures in only microseconds, on average, implying that there is a folding

Southern California, University of

263

Polypeptide chain collapse and protein folding Jayant B. Udgaonkar  

E-Print Network [OSTI]

Review Polypeptide chain collapse and protein folding Jayant B. Udgaonkar National Centre is an integral component of a protein folding reaction. In this review, exper- imental characterization solvent [2]. A distinctive physical feature of any protein folding reaction is the greater than 3-fold

264

Automated Discovery of Structural Signatures of Protein Fold and Function  

E-Print Network [OSTI]

Automated Discovery of Structural Signatures of Protein Fold and Function Marcel Turcotte1 sys- tematically for protein fold signatures, we have explored the use of Inductive Logic Programming fold. The work showed that signatures of protein folds exist, about half of rules discov- ered

Muggleton, Stephen H.

265

Seat Belt Use Policy Outline the policy regarding use of seat belt in University of Michigan (U-M) vehicles.  

E-Print Network [OSTI]

are as follows: a. All occupants in the front seat of the vehicle are required to wear a seat belt. b. Children according to U-M policies and Federal, State and local laws. Policy 1. Operators are required to wear a seat they are over 4'9" tall. c. Children who are 8 years old but less than 16 years old are required to wear a seat

Kirschner, Denise

266

A Comparative Study of the Mississippian Barnett Shale, Fort Worth Basin, and Devonian Marcellus Shale, Appalachian Basin  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

A Comparative Study of the A Comparative Study of the Mississippian Barnett Shale, Fort Worth Basin, and Devonian Marcellus Shale, Appalachian Basin DOE/NETL-2011/1478 Cover. Top left: The Barnett Shale exposed on the Llano uplift near San Saba, Texas. Top right: The Marcellus Shale exposed in the Valley and Ridge Province near Keyser, West Virginia. Photographs by Kathy R. Bruner, U.S. Department of Energy (USDOE), National Energy Technology Laboratory (NETL). Bottom: Horizontal Marcellus Shale well in Greene County, Pennsylvania producing gas at 10 million cubic feet per day at about 3,000 pounds per square inch. Photograph by Tom Mroz, USDOE, NETL, February 2010. ACKNOWLEDGMENTS The authors greatly thank Daniel J. Soeder (U.S. Department of Energy) who kindly reviewed the manuscript. His criticisms,

267

Heteropolymer Folding 9 1. C. Gh'elis and J. Yon, Protein Folding (Academic, New York, 1982).  

E-Print Network [OSTI]

Heteropolymer Folding 9 References 1. C. Gh'elis and J. Yon, Protein Folding (Academic, New York, editor, The Protein Folding Problem (Westview, Boulder, 1984).. 5. N. Gâ??o, Annu. Rev. Biophys. Bioeng. 12 for Protein Folding, Europhys. Lett. 6, 307 (1988). 14. G. Iori, E. Marinari, G. Parisi and M. V. Struglia

Roma "La Sapienza", Università di

268

Planning to fold multiple objects from a single self-folding sheet  

E-Print Network [OSTI]

This paper considers planning and control algorithms that enable a programmable sheet to realize different shapes by autonomous folding. Prior work on self-reconfiguring machines has considered modular systems in which ...

An, Byoung Kwon

269

Data From HANE-Generated Radiation Belts and the Origin of Diffusion Theory  

SciTech Connect (OSTI)

In this presentation we briefly review some of the published data regarding the artificial radiation belts produced by the Starfish and R2 high altitude nuclear explosions in 1962. The data showed slow temporal variations of the belts in altitude (L) and pitch angle ({alpha}) that could be modeled as a diffusion process. That early work formed the basis for more complex radiation belt diffusion models that are in use at present.

Winske, Dan [Los Alamos National Laboratory

2012-07-16T23:59:59.000Z

270

New Monte Carlo Algorithm for Protein Folding  

Science Journals Connector (OSTI)

We demonstrate that the recently introduced pruned-enriched Rosenbluth method leads to extremely efficient algorithms for the folding of simple model proteins. We test them on several models for lattice heteropolymers, and compare the results to published Monte Carlo studies. In all cases our algorithms are faster than previous ones, and in several cases we find new minimal energy states. In addition, our algorithms give estimates for the partition sum at finite temperatures.

Helge Frauenkron; Ugo Bastolla; Erwin Gerstner; Peter Grassberger; Walter Nadler

1998-04-06T23:59:59.000Z

271

Simple Models of the Protein Folding Problem  

E-Print Network [OSTI]

The protein folding problem has attracted an increasing attention from physicists. The problem has a flavor of statistical mechanics, but possesses the most common feature of most biological problems -- the profound effects of evolution. I will give an introduction to the problem, and then focus on some recent work concerning the so-called ``designability principle''. The designability of a structure is measured by the number of sequences that have that structure as their unique ground state. Structures differ drastically in terms of their designability; highly designable structures emerge with a number of associated sequences much larger than the average. These highly designable structures 1) possess ``proteinlike'' secondary structures and motifs, 2) are thermodynamically more stable, and 3) fold faster than other structures. These results suggest that protein structures are selected in nature because they are readily designed and stable against mutations, and that such selection simultaneously leads to thermodynamic stability and foldability. According to this picture, a key to the protein folding problem is to understand the emergence and the properties of the highly designable structures.

Chao Tang

1999-12-26T23:59:59.000Z

272

E-Print Network 3.0 - altai metallogenic belt Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

occur primarily... the Magondi Mobile Belt. In contrast, the cratonic regions are highly anisotropic - evidence of strong lateral... Exploration. Clifford, T.N., 1966,...

273

E-Print Network 3.0 - automatic seat belts Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

in the United States?: A Meta-analysis University... technology and by changing automobile driver behavior (Desai and You 1992). Seat belt laws are thought... to be the...

274

E-Print Network 3.0 - associations kaoko belt Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and the resulting burial... Petroleum Resources Project An Estimate of Recoverable Heavy Oil Resources of the Orinoco Oil Belt... barrels of technically recoverable heavy oil in...

275

E-Print Network 3.0 - asteroid belt analogs Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

these enhanced telescopes can achieve... the solar system. Figure 1 depicts the inner solar system, showing the main asteroid belt between the orbits... of Mars and Jupiter....

276

E-Print Network 3.0 - asian orogenic belt Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

All rights reserved. 0022-1376200711503-000415.00 Orogenic Belts and Orogenic Sediment Provenance Summary: rights reserved. 0022-1376200711503-000415.00 315 Orogenic...

277

Selected bibliography of the Southern Appalachian basin area: Alabama-Georgia-Kentucky-North Carolina-South Carolina-Tennessee-Virginia-West Virginia  

SciTech Connect (OSTI)

This bibliography contains 2972 records related to the geology of the Southern Appalachian basin. Specific topics include, but are not limited to: coal, petroleum, oil shale, and natural gas deposits; mineralogy; lithology; petrology; stratigraphy; tectonics; drilling; geochemistry; geophysics; geologic structures; and uranium deposits. The subject index provides listings of records related to each state and the geologic ages covered by this area. Some of the items (24) are themselves bibliographies.

Lindh, L.; McLaughlin, J.E.

1985-01-01T23:59:59.000Z

278

Structure of a Folding Intermediate Reveals the Interplay Between Core and Peripheral Elements in RNA Folding  

SciTech Connect (OSTI)

Though the molecular architecture of many native RNA structures has been characterized, the structures of folding intermediates are poorly defined. Here, we present a nucleotide-level model of a highly structured equilibrium folding intermediate of the specificity domain of the Bacillus subtilis RNase P RNA, obtained using chemical and nuclease mapping, circular dichroism spectroscopy, small-angle X-ray scattering and molecular modeling. The crystal structure indicates that the 154 nucleotide specificity domain is composed of several secondary and tertiary structural modules. The structure of the intermediate contains modules composed of secondary structures and short-range tertiary interactions, implying a sequential order of tertiary structure formation during folding. The intermediate lacks the native core and several long-range interactions among peripheral regions, such as a GAAA tetraloop and its receptor. Folding to the native structure requires the local rearrangement of a T-loop in the core in concert with the formation of the GAAA tetraloop-receptor interaction. The interplay of core and peripheral structure formation rationalizes the high degree of cooperativity observed in the folding transition leading to the native structure.

Baird, Nathan J.; Westhof, Eric; Qin, Hong; Pan, Tao; Sosnick, Tobin R. (UC); (CNFRS)

2010-07-13T23:59:59.000Z

279

Solvent-Mediated Folding of a Doubly Charged Anion. | EMSL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Solvent-Mediated Folding of a Doubly Charged Anion. Solvent-Mediated Folding of a Doubly Charged Anion. Abstract: The microsolvation of suberate dianion, -O2C(CH2)6CO2-, with two...

280

Computational and experimental investigations of forces in protein folding  

E-Print Network [OSTI]

in protein folding is essential to the understanding and treatment of protein misfolding diseases. When proteins fold, a significant amount of surface area is buried in the protein interior. It has long been known that burial of hydrophobic surface area...

Schell, David Andrew

2005-02-17T23:59:59.000Z

Note: This page contains sample records for the topic "appalachian fold belt" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Why are MD simulated protein folding times wrong? Dmitry Nerukh  

E-Print Network [OSTI]

Why are MD simulated protein folding times wrong? Dmitry Nerukh Unilever Centre for Molecular.ac.uk The question of significant deviations of protein folding times simulated using molecular dynamics from

Nerukh, Dmitry

282

New Crystal Structures Lift Fog around Protein Folding  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

New Crystal Structures Lift Fog around Protein Folding New Crystal Structures Lift Fog around Protein Folding Print Wednesday, 25 July 2012 00:00 Nature's proteins set a high bar...

283

Experimental and Computational Studies on Protein Folding, Misfolding and Stability  

E-Print Network [OSTI]

Proteins need fold to perform their biological function. Thus, understanding how proteins fold could be the key to understanding life. In the first study, the stability and structure of several !-hairpin peptide variants derived from the C...

Wei, Yun

2010-07-14T23:59:59.000Z

284

Protein Folding Simulation in CCP Luca Bortolussi1  

E-Print Network [OSTI]

Protein Folding Simulation in CCP Luca Bortolussi1 , Alessandro Dal Pal`u1 , Agostino Dovier1 as the protein folding. This problem is fundamental for biological and pharmaceutical research. Currently

Bortolussi, Luca

285

Protein Folding Simulation by Two-Stage Optimization  

Science Journals Connector (OSTI)

This paper proposes a two-stage optimization approach for protein folding simulation in the FCC lattice, inspired from...

A. Dayem Ullah; L. Kapsokalivas; M. Mann…

2009-01-01T23:59:59.000Z

286

Precambrian Research 136 (2005) 2750 The Wadi Mubarak belt, Eastern Desert of Egypt  

E-Print Network [OSTI]

Precambrian Research 136 (2005) 27­50 The Wadi Mubarak belt, Eastern Desert of Egypt, Graz, Austria b Mansoura University, Faculty of Science, Geology Department, El Mansoura, Egypt c February 2003; accepted 3 September 2004 Abstract The Wadi Mubarak belt in Egypt strikes west­east (and

Fritz, Harald

287

Are energetic electrons in the solar wind the source of the outer radiation belt?  

E-Print Network [OSTI]

Are energetic electrons in the solar wind the source of the outer radiation belt? Xinlin Li,1 D. N in the solar wind are the source of the outer rela- tivistic electron radiation belt. Though there is some the correlation of en- ergetic electrons in the 20-200 keV range in the solar wind and of high speed solar wind

Li, Xinlin

288

Improving the Availability and Delivery of Critical Information for Tight Gas Resource Development in the Appalachian Basin  

SciTech Connect (OSTI)

To encourage, facilitate and accelerate the development of tight gas reservoirs in the Appalachian basin, the geological surveys in Pennsylvania and West Virginia collected widely dispersed data on five gas plays and formatted these data into a large database that can be accessed by individual well or by play. The database and delivery system that were developed can be applied to any of the 30 gas plays that have been defined in the basin, but for this project, data compilation was restricted to the following: the Mississippian-Devonian Berea/Murrysville sandstone play and the Upper Devonian Venango, Bradford and Elk sandstone plays in Pennsylvania and West Virginia; and the 'Clinton'/Medina sandstone play in northwestern Pennsylvania. In addition, some data were collected on the Tuscarora Sandstone play in West Virginia, which is the lateral equivalent of the Medina Sandstone in Pennsylvania. Modern geophysical logs are the most common and cost-effective tools for evaluating reservoirs. Therefore, all of the well logs in the libraries of the two surveys from wells that had penetrated the key plays were scanned, generating nearly 75,000 scanned e-log files from more than 40,000 wells. A standard file-naming convention for scanned logs was developed, which includes the well API number, log curve type(s) scanned, and the availability of log analyses or half-scale logs. In addition to well logs, other types of documents were scanned, including core data (descriptions, analyses, porosity-permeability cross-plots), figures from relevant chapters of the Atlas of Major Appalachian Gas Plays, selected figures from survey publications, and information from unpublished reports and student theses and dissertations. Monthly and annual production data from 1979 to 2007 for West Virginia wells in these plays are available as well. The final database also includes digitized logs from more than 800 wells, sample descriptions from more than 550 wells, more than 600 digital photos in 1-foot intervals from 11 cores, and approximately 260 references for these plays. A primary objective of the research was to make data and information available free to producers through an on-line data delivery model designed for public access on the Internet. The web-based application that was developed utilizes ESRI's ArcIMS GIS software to deliver both well-based and play-based data that are searchable through user-originated queries, and allows interactive regional geographic and geologic mapping that is play-based. System tools help users develop their customized spatial queries. A link also has been provided to the West Virginia Geological Survey's 'pipeline' system for accessing all available well-specific data for more than 140,000 wells in West Virginia. However, only well-specific queries by API number are permitted at this time. The comprehensive project web site (http://www.wvgs.wvnet.edu/atg) resides on West Virginia Geological Survey's servers and links are provided from the Pennsylvania Geological Survey and Appalachian Oil and Natural Gas Research Consortium web sites.

Mary Behling; Susan Pool; Douglas Patchen; John Harper

2008-12-31T23:59:59.000Z

289

Innovative Methodology for Detection of Fracture-Controlled Sweet Spots in the Northern Appalachian Basin  

SciTech Connect (OSTI)

For two consecutive years, 2004 and 2005, the largest natural gas well (in terms of gas flow/day) drilled onshore USA targeted the Ordovician Trenton/Black River (T/BR) play in the Appalachian Basin of New York State (NYS). Yet, little data were available concerning the characteristics of the play, or how to recognize and track T/BR prospects across the region. Traditional exploration techniques for entry into a hot play were of limited use here, since existing deep well logs and public domain seismic were almost non-existent. To help mitigate this problem, this research project was conceived with two objectives: (1) to demonstrate that integrative traditional and innovative techniques could be used as a cost-effective reconnaissance exploration methodology in this, and other, areas where existing data in targeted fracture-play horizons are almost non-existent, and (2) determine critical characteristics of the T/BR fields. The research region between Seneca and Cayuga lakes (in the Finger Lakes of NYS) is on strike and east of the discovery fields, and the southern boundary of the field area is about 8 km north of more recently discovered T/BR fields. Phase I, completed in 2004, consisted of integrating detailed outcrop fracture analyses with detailed soil gas analyses, lineaments, stratigraphy, seismic reflection data, well log data, and aeromagnetics. In the Seneca Lake region, Landsat lineaments (EarthSat, 1997) were coincident with fracture intensification domains (FIDs) and minor faults observed in outcrop and inferred from stratigraphy. Soil gas anomalies corresponded to ENE-trending lineaments and FIDs. N- and ENE-trending lineaments were parallel to aeromagnetic anomalies, whereas E-trending lineaments crossed aeromagnetic trends. 2-D seismic reflection data confirmed that the E-trending lineaments and FIDs occur where shallow level Alleghanian salt-cored thrust-faulted anticlines occur. In contrast, the ENE-trending FIDs and lineaments occur where Iapetan rift faults have been episodically reactivated, and a few of these faults extend through the entire stratigraphic section. The ENE-trending faults and N-striking transfer zones controlled the development of the T/BR grabens. In both the Seneca Lake and Cayuga Lake regions, we found more FIDs than Landsat lineaments, both in terms of individual FIDs and trends of FIDs. Our fused Landsat/ASTER image provided more lineaments, but the structural framework inferred from these lineaments is incomplete even for the fused image. Individual lineaments may not predict surface FIDs (within 500m). However, an individual lineament that has been groundtruthed by outcrop FIDs can be used as a proxy for the trend of intense fracturing. Aeromagnetics and seismic reflection data across the discovery fields west of Keuka Lake demonstrate that the fields terminate on the east against northerly-striking faults that extend from Precambrian basement to, in some cases, the surface; the fields terminate in the west at N- and NW-striking faults. Seismic and well log data show that the fields must be compartmentalized, since different parts of the same field show different histories of development. T/BR fields south of the research area also terminate (on the east) against northerly-trending lineaments which we suggest mark faults. Phase II, completed in 2006, consisted of collection and analysis of an oriented, horizontal core retrieved from one of the T/BR fields in a graben south of the field area. The field is located along ENE-trending EarthSat (1997) lineaments, similar to that hypothesized for the study area. The horizontal core shows much evidence for reactivation along the ENE-trending faults, with multiple events of vein development and both horizontal and vertical stylolite growth. Horizontal veins that post- and pre-date other vein sets indicate that at least two orogenic phases (separated by unloading) affected vein development. Many of the veins and releasing bend features (rhombochasms) are consistent with strike-slip motion (oblique) along ENE-striking faults as a result

Robert Jacobi; John Fountain; Stuart Loewenstein; Edward DeRidder; Bruce Hart

2007-03-31T23:59:59.000Z

290

A Multi-camera Vision System for Real-Time Tracking of Parcels Moving on a Conveyor Belt  

Science Journals Connector (OSTI)

We consider the problem of designing a vision system for tracking parcels moving on a conveyor belt. After computing parcels dimensions, i.e., length, width and height, at the entrance of the conveyor belt using ...

Hüseyin N. Karaca; Cüneyt Ak?nlar

2005-01-01T23:59:59.000Z

291

Distribution of Protein Folds in the Three Superkingdoms of Life  

E-Print Network [OSTI]

Distribution of Protein Folds in the Three Superkingdoms of Life Yuri I. Wolf,1,4 Steven E. Brenner Pharmacology and Biological Chemistry, Northwestern University, Chicago, Illinois 60611 USA A sensitive protein-fold to protein kinases, -propellers and TIM-barrels. The observed diversity of protein folds in different

292

Combinatorial Problems on Strings with Applications to Protein Folding  

E-Print Network [OSTI]

Combinatorial Problems on Strings with Applications to Protein Folding Alantha Newman MIT San Jose, CA 95120, USA ruhl@almaden.ibm.com Abstract We consider the problem of protein folding in linear time. 1 Introduction We consider the problem of protein folding in the HP model on the three

Newman, Alantha

293

Protein Folding Simulation by Two-Stage Optimization  

E-Print Network [OSTI]

Protein Folding Simulation by Two-Stage Optimization A. Dayem Ullah1 , L. Kapsokalivas1 , M. Mann2 propose a two-stage optimization approach for protein folding simulation in the FCC lattice, inspired from procedure based on simulated annealing alone. 1 Introduction The question of how proteins fold and whether

Will, Sebastian

294

Protein folding with stochastic L-systems Gemma Danks1  

E-Print Network [OSTI]

Protein folding with stochastic L-systems Gemma Danks1 , Susan Stepney1 and Leo Caves1 1 University-like structures. Models of protein folding vary in complexity and the amount of prior knowledge they contain). The energy landscape theory of protein folding (Onuchic et al., 1997) predicts a rugged funnel-like energy

Stepney, Susan

295

Protein Folding Challenge and Theoretical Computer Science Somenath Biswas  

E-Print Network [OSTI]

Protein Folding Challenge and Theoretical Computer Science Somenath Biswas Department of Computer the chain of amino acids that defines a protein. The protein folding problem is: given a sequence of amino to use an efficient algorithm to carry out protein folding. The atoms in a protein molecule attract each

Biswas, Somenath

296

Femtomole Mixer for Microsecond Kinetic Studies of Protein Folding  

E-Print Network [OSTI]

Femtomole Mixer for Microsecond Kinetic Studies of Protein Folding David E. Hertzog,, Xavier a microfluidic mixer for studying protein folding and other reactions with a mixing time of 8 µs and sample) measurements of single-stranded DNA. We also demon- strate the feasibility of measuring fast protein folding

Michalet, Xavier

297

Polymer Collapse, Protein Folding, and the Percolation Threshold  

E-Print Network [OSTI]

Polymer Collapse, Protein Folding, and the Percolation Threshold HAGAI MEIROVITCH University (Macromolecules 1989, 22, 3986­3997) to study protein folding, where H and P are the hydrophobic and polar amino; computer simulation; collapse transition; protein folding Introduction The behavior of dilute polymer

Meirovitch, Hagai

298

Thermodynamics of Protein Folding from Coarse-Grained Models' Perspectives  

E-Print Network [OSTI]

8 Thermodynamics of Protein Folding from Coarse-Grained Models' Perspectives Michael Bachmann applications. In this lecture, we focus on the anal- ysis of mesoscopic models for protein folding, aggregation for a more universal description of the notoriously difficult problem of protein fold- ing. In this approach

Janke, Wolfhard

299

Author's personal copy Protein folding in confined and crowded environments  

E-Print Network [OSTI]

Author's personal copy Review Protein folding in confined and crowded environments Huan-Xiang Zhou protein folding in cellular environments. Theories based on considerations of excluded volumes predict disparate effects on protein folding stability for confinement and crowding: confinement can stabilize

Weston, Ken

300

John von Neumann Institute for Computing Monte Carlo Protein Folding  

E-Print Network [OSTI]

John von Neumann Institute for Computing Monte Carlo Protein Folding: Simulations of Met://www.fz-juelich.de/nic-series/volume20 #12;#12;Monte Carlo Protein Folding: Simulations of Met-Enkephalin with Solvent-Accessible Area difficulties in applying Monte Carlo methods to protein folding. The solvent-accessible area method, a popular

Hsu, Hsiao-Ping

Note: This page contains sample records for the topic "appalachian fold belt" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Protein folding: Then and now Yiwen Chen 1  

E-Print Network [OSTI]

Review Protein folding: Then and now Yiwen Chen 1 , Feng Ding 1 , Huifen Nie 1 , Adrian W decades the protein folding field has undergone monumental changes. Originally a purely academic question, how a protein folds has now become vital in understanding diseases and our abilities to rationally

Dokholyan, Nikolay V.

302

Author's personal copy Protein folding: Then and now  

E-Print Network [OSTI]

Author's personal copy Review Protein folding: Then and now Yiwen Chen 1 , Feng Ding 1 , Huifen Nie Available online 8 June 2007 Abstract Over the past three decades the protein folding field has undergone monumental changes. Originally a purely academic question, how a protein folds has now become vital

Dokholyan, Nikolay V.

303

Modeling Protein Folding Pathways Christopher Bystroff, Yu Shao  

E-Print Network [OSTI]

Modeling Protein Folding Pathways Christopher Bystroff, Yu Shao Dept of Biology Rensselaer Polytechnic Institute, Troy, NY. e-mail:{bystrc, shaoy}@rpi.edu Summary Proteins fold through a series of intermediate states called a pathway. Protein folding pathways have been modeled using either simulations

Bystroff, Chris

304

COMMUNICATION Are Residues in a Protein Folding Nucleus  

E-Print Network [OSTI]

COMMUNICATION Are Residues in a Protein Folding Nucleus Evolutionarily Conserved? Yan Yuan Tseng is the hallmark of life. It is important to understand how protein folding and evolution influence each other in protein folding nucleus as measured by experi- mental f-value and selection pressure as measured by v

Dai, Yang

305

MATHEMATICAL MODELS OF PROTEIN FOLDING Daniel B. Dix  

E-Print Network [OSTI]

MATHEMATICAL MODELS OF PROTEIN FOLDING Daniel B. Dix Department of Mathematics University of South Carolina Abstract. We present an elementary introduction to the protein folding problem directed toward, and biological problem, protein folding can also be precisely formulated as a set of mathematics problems. We

Dix, Daniel B.

306

Evolutionary Monte Carlo for protein folding simulations Faming Lianga)  

E-Print Network [OSTI]

Evolutionary Monte Carlo for protein folding simulations Faming Lianga) Department of Statistics to simulations of protein folding on simple lattice models, and to finding the ground state of a protein. In all structures in protein folding. The numerical results show that it is drastically superior to other methods

Liang, Faming

307

Steiner Minimal Trees, Twist Angles, and the Protein Folding Problem  

E-Print Network [OSTI]

Steiner Minimal Trees, Twist Angles, and the Protein Folding Problem J. MacGregor Smith, Yunho Jang. These properties should be ultimately useful in the ab ini- tio protein folding prediction. Proteins 2007;66:889­ 902. VVC 2006 Wiley-Liss, Inc. Key words: Steiner trees; twist angles; protein fold- ing; side chain

Smith, J. MacGregor

308

Folding simulations of small proteins Seung-Yeon Kima  

E-Print Network [OSTI]

Abstract Understanding how a protein folds is a long-standing challenge in modern science. We have used-native conformations are carried out for each protein. In all cases, proteins fold into their native-like conformations, ~108 Monte Carlo steps). D 2004 Elsevier B.V. All rights reserved. Keywords: Protein folding; Computer

Lee, Jooyoung

309

Introduction to protein folding for physicists  

E-Print Network [OSTI]

The prediction of the three-dimensional native structure of proteins from the knowledge of their amino acid sequence, known as the protein folding problem, is one of the most important yet unsolved issues of modern science. Since the conformational behaviour of flexible molecules is nothing more than a complex physical problem, increasingly more physicists are moving into the study of protein systems, bringing with them powerful mathematical and computational tools, as well as the sharp intuition and deep images inherent to the physics discipline. This work attempts to facilitate the first steps of such a transition. In order to achieve this goal, we provide an exhaustive account of the reasons underlying the protein folding problem enormous relevance and summarize the present-day status of the methods aimed to solving it. We also provide an introduction to the particular structure of these biological heteropolymers, and we physically define the problem stating the assumptions behind this (commonly implicit) definition. Finally, we review the 'special flavor' of statistical mechanics that is typically used to study the astronomically large phase spaces of macromolecules. Throughout the whole work, much material that is found scattered in the literature has been put together here to improve comprehension and to serve as a handy reference.

Pablo Echenique

2007-05-13T23:59:59.000Z

310

Green belts in the hands and minds of farmers: A socio-agronomical approach to farmers' practices  

E-Print Network [OSTI]

1 Green belts in the hands and minds of farmers: A socio-agronomical approach to farmers' practices.alavoine-mornas@irstea.fr ; sabine.girard@irstea.fr Keywords: green belts - biodiversity ­ farmers practices ­ French Alps Abstract of intensive agriculture. In France, this topic is addressed by the "blue and green belts" measure, which

Paris-Sud XI, Université de

311

Folding Kinetics of the Cooperatively Folded Subdomain of the IB Ankyrin Repeat Domain  

E-Print Network [OSTI]

Naturales, Universidad de Buenos Aires, C1428EGA Buenos Aires, Argentina 3 Consejo Nacional de Investigaciones Cientificas y Tecnicas de Argentina, C1428EGA Buenos Aires, Argentina Received 17 December 2010 complex folding kinetics, with two sequential on-pathway high-energy intermedi- ates. The effect

Komives, Elizabeth A.

312

Protein-Folding Landscapes in Multi-Chain Systems  

SciTech Connect (OSTI)

Computational studies of proteins have significantly improved our understanding of protein folding. These studies are normally carried out using chains in isolation. However, in many systems of practical interest, proteins fold in the presence of other molecules. To obtain insight into folding in such situations, we compare the thermodynamics of folding for a Miyazawa-Jernigan model 64-mer in isolation to results obtained in the presence of additional chains. The melting temperature falls as the chain concentration increases. In multi-chain systems, free-energy landscapes for folding show an increased preference for misfolded states. Misfolding is accompanied by an increase in inter-protein interactions; however, near the folding temperature, the transition from folded chains to misfolded and associated chains isentropically driven. A majority of the most probable inter-protein contacts are also native contacts, suggesting that native topology plays a role in early stages of aggregation.

Cellmer, Troy; Bratko, Dusan; Prausnitz, John M.; Blanch, Harvey

2005-06-20T23:59:59.000Z

313

The Quirky Collider Signals of Folded Supersymmetry  

SciTech Connect (OSTI)

We investigate the collider signals associated with scalar quirks ('squirks') in folded supersymmetric models. As opposed to regular superpartners in supersymmetric models these particles are uncolored, but are instead charged under a new confining group, leading to radically different collider signals. Due to the new strong dynamics, squirks that are pair produced do not hadronize separately, but rather form a highly excited bound state. The excited 'squirkonium' loses energy to radiation before annihilating back into Standard Model particles. We calculate the branching fractions into various channels for this process, which is prompt on collider time-scales. The most promising annihilation channel for discovery is W+photon which dominates for squirkonium near its ground state. We demonstrate the feasibility of the LHC search, showing that the mass peak is visible above the SM continuum background and estimate the discovery reach.

Burdman, Gustavo; Chacko, Z.; Goh, Hock-Seng; Harnik, Roni; Krenke, Christopher A.

2008-08-01T23:59:59.000Z

314

The folding energy landscape of Cytochrome c : theoretical and experimental investigations  

E-Print Network [OSTI]

Chemical Frustration in the Protein Folding Landscape: GrandChemical Frustration in the Protein Folding Landscape: GrandEnzyme Catalysis and Protein Folding (Freeman, New York). [

Weinkam, Patrick

2009-01-01T23:59:59.000Z

315

Topology, frustration, folding and function of the inflammatory cytokine Interleukin-1[beta  

E-Print Network [OSTI]

the features of protein folding, where proteins with manychain connectivity on protein folding (53). Application ofhave gone beyond protein folding and have characterized

Capraro, Dominique T.

2008-01-01T23:59:59.000Z

316

Carbon-deuterium bonds as an infrared probe of protein dynamics, local electrostatics and folding  

E-Print Network [OSTI]

and Englander, W. S. , Protein Folding: A Stepwise AssemblyEnglander, S. W. , Protein Folding Intermediates – NativeR. L. , How Does Protein Folding Get Started? Trends

Sagle, Laura B.

2006-01-01T23:59:59.000Z

317

Beyond the native state: Exploring the role of partially folded conformations on the protein energy landscape  

E-Print Network [OSTI]

L. & Englander, S. W. (1995). Protein folding intermediates:Unifying features in protein- folding mechanisms. Proc Natlintermediate state in protein folding by a hydrophobic

Connell, Katelyn Blair

2010-01-01T23:59:59.000Z

318

Energy landscapes for protein folding, binding, and aggregation : simple funnels and beyond  

E-Print Network [OSTI]

coordinates capture protein folding on smooth landscapes.in the Prediction of Protein Folding Kinetics. Proc. Natl.Landscapes for Protein Folding, Binding, and Aggregation:

Cho, Samuel Sung-Il

2007-01-01T23:59:59.000Z

319

Structural proteomics of minimal organisms: conservation of protein fold usage and evolutionary implications  

E-Print Network [OSTI]

e A) Variation in fold usage between organisms, in differentB) Variation in fold usage between minimal organisms onlyConservation of protein fold usage and evolutionary

Chandonia, John-Marc; Kim, Sung-Hou

2006-01-01T23:59:59.000Z

320

Microfluidic advantage : novel techniques for protein folding and oxygen control in cell cultures  

E-Print Network [OSTI]

Novel Techniques for Protein Folding and Oxygen Control inTemperature Jump System to Study Fast Protein FoldingNovel Techniques for Protein Folding and Oxygen Control in

Polinkovsky, Mark E.; Polinkovsky, Mark E.

2012-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "appalachian fold belt" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Accordian-folded boot shield for flexible swivel connection  

SciTech Connect (OSTI)

This patent describes an apparatus for connecting a first boot section to a second boot section, the first and second boots having openings therethrough, the second boot having at least two adjacent accordion folds at the end having the opening. The second boot is positioned through the opening of the first boot such that a first of the accordion folds is within the first boot and a second of the accordion folds is outside of the first boot comprising: first and second annular discs, the first disc being positioned within and across the first accordion fold, the second disc being positioned within and across the second accordion fold such that the first boot is moveably and rigidly connected between the first and second accordion folds.

Hoh, J.C.

1986-08-26T23:59:59.000Z

322

An energy landscape theory for cotranslational protein folding  

E-Print Network [OSTI]

Energy landscape theory describes how a full-length protein can attain its native fold by sampling only a tiny fraction of all possible structures. Although protein folding is now understood to be concomitant with synthesis on the ribosome, there have been few attempts to modify energy landscape theory by accounting for cotranslational folding. This paper introduces a model for cotranslational folding that leads to a natural definition of a nested energy landscapes. By applying concepts drawn from submanifold differential geometry, the dynamics of protein folding on the ribosome can be explored in a quantitative manner and conditions on the nested potential energy landscapes for a good cotranslational folder are obtained. A generalisation of diffusion rate theory using van Kampen's technique of composite stochastic processes is then used to account for entropic contributions and the effects of variable translation rates on cotranslational folding. This stochastic approach agrees well with experimental results...

Tourigny, David S

2013-01-01T23:59:59.000Z

323

Inferring the Rate-Length Law of Protein Folding  

E-Print Network [OSTI]

We investigate the rate-length scaling law of protein folding, a key undetermined scaling law in the analytical theory of protein folding. We demonstrate that chain length is a dominant factor determining folding times, and that the unambiguous determination of the way chain length corre- lates with folding times could provide key mechanistic insight into the folding process. Four specific proposed laws (power law, exponential, and two stretched exponentials) are tested against one an- other, and it is found that the power law best explains the data. At the same time, the fit power law results in rates that are very fast, nearly unreasonably so in a biological context. We show that any of the proposed forms are viable, conclude that more data is necessary to unequivocally infer the rate-length law, and that such data could be obtained through a small number of protein folding experiments on large protein domains.

Lane, Thomas J

2013-01-01T23:59:59.000Z

324

A dynamical approach to protein folding  

E-Print Network [OSTI]

In this paper we show that a dynamical description of the protein folding process provides an effective representation of equilibrium properties and it allows for a direct investigation of the mechanisms ruling the approach towards the native configuration. The results reported in this paper have been obtained for a two-dimensional toy-model of amino acid sequences, whose native configurations were previously determined by Monte Carlo techniques. The somewhat controversial scenario emerging from the comparison among various thermodynamical indicators is definitely better resolved relying upon a truly dynamical description, that points out the crucial role played by long-range interactions in determining the characteristic step-wise evolution of ``good'' folders to their native state. It is worth stressing that this dynamical scenario is consistent with the information obtained by exploring the energy landscapes of different sequences. This suggests that even the identification of more efficient ``static'' indicators should take into account the peculiar features associated with the complex ``orography'' of the landscape.

Alessandro Torcini; Roberto Livi; Antonio Politi

2001-03-13T23:59:59.000Z

325

Energy landscapes, folding mechanisms and kinetics of RNA tetraloop hairpins  

Science Journals Connector (OSTI)

Energy landscapes, folding mechanisms and kinetics of RNA tetraloop hairpins ... In this work, we use the discrete path sampling (DPS) approach to explore the energy landscapes of two RNA tetraloop hairpins, and provide insights into their folding mechanisms and kinetics in atomistic detail. ... Our results show that the potential energy landscapes have a distinct funnel-like bias towards the folded hairpin state, consistent with efficient structure-seeking properties. ...

Debayan Chakraborty; Rosana Collepardo-Guevara; David J. Wales

2014-12-02T23:59:59.000Z

326

A Computational Genome-wide Study of Protein Folding Rate.  

E-Print Network [OSTI]

??Proteins should be able to ‘fold’ to a native three-dimensional structure in a biologically relevant time to be functional. In our current study, we tried… (more)

Gorla, Sandeep C.

2012-01-01T23:59:59.000Z

327

THE GEODESIC X-RAY TRANSFORM WITH FOLD CAUSTICS The ...  

E-Print Network [OSTI]

Aug 28, 2012 ... THE GEODESIC X-RAY TRANSFORM WITH FOLD CAUSTICS. PLAMEN STEFANOV AND GUNTHER UHLMANN. ABSTRACT. We give a ...

2012-08-28T23:59:59.000Z

328

Application of optical tweezers in protein folding studies.  

E-Print Network [OSTI]

??Force spectroscopy has proven to be a very promising tool in the protein folding field. With multiple setups and methods to exert force it has… (more)

Kooijman, L.

2014-01-01T23:59:59.000Z

329

Topological complexity, contact order and protein folding rates  

E-Print Network [OSTI]

Monte Carlo simulations of protein folding show the emergence of a strong correlation between the relative contact order parameter, CO, and the folding time, t, of two-state folding proteins for longer chains with number of amino acids, N>=54, and higher contact order, CO > 0.17. The correlation is particularly strong for N=80 corresponding to slow and more complex folding kinetics. These results are qualitatively compatible with experimental data where a general trend towards increasing t with CO is indeed observed in a set of proteins with chain length ranging from 41 to 154 amino acids.

P. F. N. Faisca; R. C. Ball

2002-05-29T23:59:59.000Z

330

Variational theory for site resolved protein folding free energy surfaces  

E-Print Network [OSTI]

We present a microscopic variational theory for the free energy surface of a fast folding protein that allows folding kinetics to be resolved to the residue level using Debye-Waller factors as local order parameters. We apply the method to lambda-repressor and compare with site directed mutagenesis experiments. The formation of native structure and the free energy profile along the folding route are shown to be well described by the capillarity approximation but with some fine structure due to local folding topology.

John J. Portman; Shoji Takada; Peter G. Wolynes

1999-01-18T23:59:59.000Z

331

Protein folding and diffusion: from in vitro to live cells.  

E-Print Network [OSTI]

??Protein folding landscapes and protein-protein interaction landscapes are subject to modulation by many factors inside living cells: crowding, electrostatics, hydrophobic interactions, and even hydrodynamic phenomena.… (more)

Guo, Minghao

2014-01-01T23:59:59.000Z

332

Biophysical Studies of Protein Folding and Binding Stability.  

E-Print Network [OSTI]

?? Interactions between charged residues are known to have significant effects on protein folding stability and binding properties. The contributions of different types of non-covalent… (more)

Batra, Jyotica

2009-01-01T23:59:59.000Z

333

Thermodynamics of protein folding: a random matrix formulation  

E-Print Network [OSTI]

The process of protein folding from an unfolded state to a biologically active, folded conformation is governed by many parameters e.g the sequence of amino acids, intermolecular interactions, the solvent, temperature and chaperon molecules. Our study, based on random matrix modeling of the interactions, shows however that the evolution of the statistical measures e.g Gibbs free energy, heat capacity, entropy is single parametric. The information can explain the selection of specific folding pathways from an infinite number of possible ways as well as other folding characteristics observed in computer simulation studies.

Pragya Shukla

2010-10-16T23:59:59.000Z

334

DOE Science Showcase - Protein Folding | OSTI, US Dept of Energy...  

Office of Scientific and Technical Information (OSTI)

Science Showcase - Protein Folding Proteins are the main constitute of our bones, muscles, hair, skin and blood vessels, performing a vast array of functions such as catalyzing...

335

New Crystal Structures Lift Fog around Protein Folding  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

New Crystal Structures Lift Fog around Protein Folding Print Nature's proteins set a high bar for nanotechnology. Macromolecules forged from peptide chains of amino acids, these...

336

Protein folding: A complex potential for the driving force  

E-Print Network [OSTI]

Using the Helmholtz decomposition of the vector field of folding fluxes in a reduced space of collective variables, a potential of the driving force for protein folding is determined. The potential has two components and can be written as a complex function. One component is responsible for the source and sink of the folding flows (representing, respectively, the unfolded states and the native state of the protein), and the other accounts for the vorticity of the flow that is produced at the boundaries of the main flow by the contact of the moving folding "fluid" with the quiescent surroundings. The theoretical consideration is illustrated by calculations for a model $\\beta$-hairpin protein.

Chekmarev, Sergei F

2013-01-01T23:59:59.000Z

337

Late Cretaceous extension in the hinterland of the Sevier thrust belt,  

Open Energy Info (EERE)

Late Cretaceous extension in the hinterland of the Sevier thrust belt, Late Cretaceous extension in the hinterland of the Sevier thrust belt, northwestern Utah and southern Idaho Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Journal Article: Late Cretaceous extension in the hinterland of the Sevier thrust belt, northwestern Utah and southern Idaho Details Activities (1) Areas (1) Regions (0) Abstract: Cover rocks of the Raft River metamorphic core complex, located in the Sevier belt hinterland, preserve a structural and metamorphic history that predates the middle Tertiary extension of the region. In the eastern Raft River Mountains, Cambrian-Permian rocks form two allochthons that occur in the hanging wall of the mid-Miocene Raft River detachment fault. Dramatically attenuated, metamorphosed Cambrian-Pennsylvanian strata

338

Measurements and Modelling in the Great Belt: a Unique Opportunity for Model Verification  

Science Journals Connector (OSTI)

Environmental studies initiated in conjunction with construction of a bridge across the Great Belt will offer some remarkable opportunities for scientific investigations. In this paper we provide some backgrou...

David M. Farmer; Jacob Steen Møller

1990-01-01T23:59:59.000Z

339

The Electric Field and Waves Instruments on the Radiation Belt Storm Probes Mission  

E-Print Network [OSTI]

The Electric Fields and Waves (EFW) Instruments on the two Radiation Belt Storm Probe (RBSP) spacecraft (recently renamed the Van Allen Probes) are designed to measure three dimensional quasi-static and low frequency ...

Wygant, J. R.

340

Distinguishing the Cold Conveyor Belt and Sting Jet Airstreams in an Intense Extratropical Cyclone  

Science Journals Connector (OSTI)

Strong winds equatorward and rearward of a cyclone core have often been associated with two phenomena: the cold conveyor belt (CCB) jet and sting jets. Here, detailed observations of the mesoscale structure in this region of an intense cyclone are ...

Oscar Martínez-Alvarado; Laura H. Baker; Suzanne L. Gray; John Methven; Robert S. Plant

2014-08-01T23:59:59.000Z

Note: This page contains sample records for the topic "appalachian fold belt" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

On the Co-Occurrence of Warm Conveyor Belt Outflows and PV Streamers  

Science Journals Connector (OSTI)

The co-occurrence of warm conveyor belts (WCBs), strongly ascending moist airstreams in extratropical cyclones, and stratospheric potential vorticity (PV) streamers, indicators for breaking Rossby waves on the tropopause, is investigated for a 21-...

Erica Madonna; Sebastian Limbach; Christine Aebi; Hanna Joos; Heini Wernli; Olivia Martius

2014-10-01T23:59:59.000Z

342

Subaqueous calderas in the Archean Abitibi greenstone belt: An overview and W.U. Mueller a,  

E-Print Network [OSTI]

, physical volcanology, dyke emplacement, and hydrothermal carbonate alteration. These subaqueous calderas-documented hydrothermal carbonate alteration isdiscussed and a newexploration model for calderas is presented Available online 6 January 2009 Keywords: Archean calderas VMS deposits Abitibi belt Volcanology Carbonate

Long, Bernard

343

VP 100: Brevini Wind Factory Helps Rust Belt Town's Economy | Department  

Broader source: Energy.gov (indexed) [DOE]

VP 100: Brevini Wind Factory Helps Rust Belt Town's Economy VP 100: Brevini Wind Factory Helps Rust Belt Town's Economy VP 100: Brevini Wind Factory Helps Rust Belt Town's Economy October 5, 2010 - 10:00am Addthis Brevini Wind is building a 127,000-square foot state-of-the-art factory in Muncie, Ind.| Photo courtesy of Brevini Wind Brevini Wind is building a 127,000-square foot state-of-the-art factory in Muncie, Ind.| Photo courtesy of Brevini Wind Stephen Graff Former Writer & editor for Energy Empowers, EERE What are the key facts? Brevini Wind awarded $12.8 million tax credit to build wind gear box plant Company will tap into manufacturing workforce, creating 450 jobs in next two years Faced with a recession and an auto industry that ran out gas, many manufacturing towns in the Rust Belt have reinvented themselves. Some found

344

Multi-scale and Integrated Characterization of the Marcellus Shale in the Appalachian Basin: From Microscopes to Mapping  

SciTech Connect (OSTI)

Historic data from the Department of Energy Eastern Gas Shale Project (ESGP) were compiled to develop a database of geochemical analyses, well logs, lithological and natural fracture descriptions from oriented core, and reservoir parameters. The nine EGSP wells were located throughout the Appalachian Basin and intercepted the Marcellus Shale from depths of 750 meters (2500 ft) to 2500 meters (8200 ft). A primary goal of this research is to use these existing data to help construct a geologic framework model of the Marcellus Shale across the basin and link rock properties to gas productivity. In addition to the historic data, x-ray computerized tomography (CT) of entire cores with a voxel resolution of 240mm and optical microscopy to quantify mineral and organic volumes was performed. Porosity and permeability measurements in a high resolution, steady-state flow apparatus are also planned. Earth Vision software was utilized to display and perform volumetric calculations on individual wells, small areas with several horizontal wells, and on a regional basis. The results indicate that the lithologic character of the Marcellus Shale changes across the basin. Gas productivity appears to be influenced by the properties of the organic material and the mineral composition of the rock, local and regional structural features, the current state of in-situ stress, and lithologic controls on the geometry of induced fractures during stimulations. The recoverable gas volume from the Marcellus Shale is variable over the vertical stratigraphic section, as well as laterally across the basin. The results from this study are expected to help improve the assessment of the resource, and help optimize the recovery of natural gas.

Crandall, Dustin; Soeder, Daniel J; McDannell, Kalin T.; Mroz, Thomas

2010-01-01T23:59:59.000Z

345

Effect of cropland management and slope position on soil organic carbon pool at the North Appalachian Experimental Watersheds  

Science Journals Connector (OSTI)

Soil organic matter is strongly related to soil type, landscape morphology, and soil and crop management practices. Therefore, long-term (15–36-years) effects of six cropland management systems on soil organic carbon (SOC) pool in 0–30 cm depth were studied for the period of 1939–1999 at the North Appalachian Experimental Watersheds (pool ranged from 24.5 Mg ha?1 in the 32-years moldboard tillage corn (Zea mays L.)–wheat (Triticum aestivum L.)–meadow–meadow rotation with straight row farming and annual application of fertilizer (N:P:K=5:9:17) of 56–112 kg ha?1 and cattle (Bos taurus) manure of 9 Mg ha?1 as the prevalent system (MTR-P) to 65.5 Mg ha?1 in the 36-years no tillage continuous corn with contour row farming and annual application of 170–225 kg N ha?1 and appropriate amounts of P and K, and 6–11 Mg ha?1 of cattle manure as the improved system (NTC-M). The difference in SOC pool among management systems ranged from 2.4 to 41 Mg ha?1 and was greater than 25 Mg ha?1 between NTC-M and the other five management systems. The difference in the SOC pool of NTC-M and that of no tillage continuous corn (NTC) were 16–21 Mg ha?1 higher at the lower slope position than at the middle and upper slope positions. The effect of slope positions on SOC pools of the other management systems was significantly less (water conservation farming on SOC pool were accumulative. The NTC-M treatment with application of NPK fertilizer, lime, and cattle manure is an effective cropland management system for SOC sequestration.

Y Hao; R Lal; L.B Owens; R.C Izaurralde; W.M Post; D.L Hothem

2002-01-01T23:59:59.000Z

346

Restoring Sustainable Forests on Appalachian Mined Lands for Wood Products, Renewable Energy, Carbon Sequestration, and Other Ecosystems Services  

SciTech Connect (OSTI)

The overall purpose of this project is to evaluate the biological and economic feasibility of restoring high-quality forests on mined land, and to measure carbon sequestration and wood production benefits that would be achieved from forest restoration procedures. During this quarter we worked on methodologies for analyzing carbon in mine soils. A unique property of mine soils is the presence of coal and carboniferous rock particles that are present in mine soils in various sizes, quantities, and qualities. There is no existing method in the literature that may be of use for quantitative estimation of soil organic carbon (SOC) in mine soils that can successfully differentiate between pedogenic and geogenic carbon forms. In this report we present a detailed description of a 16-step method for measuring SOC in mine soils designed for and tested on a total of 30 different mine soil mixtures representing a wide spectrum of mine soils in the hard-rock region of the Appalachian coalfield. The proposed method is a combination of chemical procedure for carbonates removal, a thermal procedure for pedogenic C removal, and elemental C analysis procedure at 900 C. Our methodology provides a means to correct for the carbon loss from the more volatile constituents of coal fragments in the mine soil samples and another correction factor for the protected organic matter that can also remain unoxidized following thermal pretreatment. The correction factors for coal and soil material-specific SOM were based on carbon content loss from coal and SOM determined by a parallel thermal oxidation analysis of pure ground coal fragments retrieved from the same mined site as the soil samples and of coal-free soil rock fragments of sandstone and siltstone origin.

James A. Burger; J. Galbraith; T. Fox; G. Amacher; J. Sullivan; C. Zipper

2006-04-30T23:59:59.000Z

347

INNOVATIVE METHODOLOGY FOR DETECTION OF FRACTURE-CONTROLLED SWEET SPOTS IN THE NORTHERN APPALACHIAN BASIN  

SciTech Connect (OSTI)

In the structure task, we completed reducing the data we had collected from a N-S transect on the east of Seneca Lake. We have calculated the fracture frequency for all the fracture sets at each site, and constructed modified rose diagrams that summarize the fracture attributes at each site. These data indicate a N-striking fault near the southeastern shore of Seneca Lake, and also indicate NE and ENE-trending FIDs and faults north of Valois. The orientation and existence of the ENE-striking FIDs and faults are thought to be guided by faults in the Precambrian basement; these basement faults apparently were sufficiently reactivated to cause faulting in the Paleozoic section. Other faults are thrust ramps above the Silurian salt section that were controlled by a far-field Alleghanian stress field. Structure contour maps and isopach maps have been revised based on additional well log analyses. Except for the Glodes Corners Field, the well spacing generally is insufficient to definitively identify faults. However, relatively sharp elevational changes east of Keuka Lake support the contention that faults occur along the east side of Keuka Lake. Outcrop stratigraphy along the east side of Seneca Lake indicates that faults and gentle folds can be inferred from the some exposures along Seneca Lake, but the lensing nature of the individual sandstones can preclude long-distance definitive correlations and structure identification. Soil gas data collected during the 2000 field season was reduced and displayed in the previous semiannual report. The seismic data that Quest licensed has been reprocessed. Several grabens observed in the Trenton reflector are consistent with surface structure, soil gas, and aeromagnetic anomalies. In this report we display an interpreted seismic line that crosses the Glodes Corners and Muck Farm fields. The final report from the subcontractor concerning the completed aeromagnetic survey is included. Prominent magnetic anomalies suggest that faults in the Precambrian basement are located beneath regions where grabens in the Trenton are located. The trend and location of these faults based on aeromagnetics agrees with the location based on FIDs. These data indicate that integration of aeromagnetic and topographic lineaments, surface structure, soil gas with seismic and well logs allows us to extrapolate Trenton-Black River trends away from confirmatory seismic lines.

Robert Jacobi; John Fountain

2002-01-30T23:59:59.000Z

348

Planar resonant periodic orbits in Kuiper belt dynamics  

E-Print Network [OSTI]

In the framework of the planar restricted three body problem we study a considerable number of resonances associated to the Kuiper Belt dynamics and located between 30 and 48 a.u. Our study is based on the computation of resonant periodic orbits and their stability. Stable periodic orbits are surrounded by regular librations in phase space and in such domains the capture of trans-Neptunian object is possible. All the periodic orbits found are symmetric and there is evidence for the existence of asymmetric ones only in few cases. In the present work first, second and third order resonances are under consideration. In the planar circular case we found that most of the periodic orbits are stable. The families of periodic orbits are temporarily interrupted by collisions but they continue up to relatively large values of the Jacobi constant and highly eccentric regular motion exists for all cases. In the elliptic problem and for a particular eccentricity value of the primary bodies the periodic orbits are isolated. The corresponding families, where they belong to, bifurcate from specific periodic orbits of the circular problem and seem to continue up to the rectilinear problem. Both stable and unstable orbits are obtained for each case. In the elliptic problem the unstable orbits found are associated with narrow chaotic domains in phase space. The evolution of the orbits, which are located in such chaotic domains, seems to be practically regular and bounded for long time intervals.

George Voyatzis; Thomas Kotoulas

2005-02-28T23:59:59.000Z

349

Thermodynamic control and dynamical regimes in protein folding  

E-Print Network [OSTI]

Monte Carlo simulations of a simple lattice model of protein folding show two distinct regimes depending on the chain length. The first regime well describes the folding of small protein sequences and its kinetic counterpart appears to be single exponential in nature, while the second regime is typical of sequences longer than 80 amino acids and the folding performance achievable is sensitive to target conformation. The extent to which stability, as measured by the energy of a sequence in the target, is an essential requirement and affects the folding dynamics of protein molecules in the first regime is investigated. The folding dynamics of sequences whose design stage was restricted to a certain fraction of randomly selected amino acids shows that while some degree of stability is a necessary and sufficient condition for successful folding, designing sequences that provide the lowest energy in the target seems to be a superfluous constraint. By studying the dynamics of under annealed but otherwise freely designed sequences we explore the relation between stability and kinetic accessibility. We find that there is no one-to-one correspondence between having low energy and folding quickly to the target, as only a small fraction of the most stable sequences were also found to fold relatively quickly.

P. F. N. Faisca; R. C. Ball

2001-10-07T23:59:59.000Z

350

Statistical Analysis of Protein Folding Kinetics Aaron R. Dinner  

E-Print Network [OSTI]

Statistical Analysis of Protein Folding Kinetics Aaron R. Dinner , Sung-Sau So ¡ , and Martin and theoretical studies over several years have led to the emergence of a unified general mechanism for protein folding that serves as a framework for the design and interpretation of research in this area [1

Dinner, Aaron

351

Multi-Agent Simulation of Protein Folding Luca Bortolussi1  

E-Print Network [OSTI]

Multi-Agent Simulation of Protein Folding Luca Bortolussi1 , Agostino Dovier1 , and Federico residues) is known. The process for reaching this state is known as the protein fold- ing. This problem the feasibility and the power of the method. Keywords: Computational Biology, Agent-Based Technologies, Protein

Bortolussi, Luca

352

A Single-Molecule Study of RNA Catalysis and Folding  

E-Print Network [OSTI]

A Single-Molecule Study of RNA Catalysis and Folding Xiaowei Zhuang,1 * Laura E. Bartley,2 * Hazen and undocks from the ribozyme core was observed directly in single-molecule time trajectories, allowing. These results establish single-molecule fluorescence as a pow- erful tool for examining RNA folding. Virtually

Herschlag, Dan

353

New Crystal Structures Lift Fog around Protein Folding  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

New Crystal Structures Lift Fog New Crystal Structures Lift Fog around Protein Folding New Crystal Structures Lift Fog around Protein Folding Print Wednesday, 25 July 2012 00:00 Nature's proteins set a high bar for nanotechnology. Macromolecules forged from peptide chains of amino acids, these biomolecular nanomachines must first be folded into a dazzling variety of shapes and forms before they can perform the multitude of functions fundamental to life. However, the mechanisms behind the protein-folding process have remained a foggy mystery. Now the fog is lifting: a team of researchers from Berkeley Lab, Stanford University, and the Massachusetts Institute of Technology has deciphered the crystal structure of a critical control element within chaperonin, the protein complex responsible for the correct folding of other proteins.

354

1.17 - Protein Folding in the Endoplasmic Reticulum  

Science Journals Connector (OSTI)

Abstract The endoplasmic reticulum (ER) is the principal protein-folding organelle for secretory and membrane proteins. Proteins are folded, assembled, and post-translationally modified in the ER. Chaperones and folding enzymes assist in this process. Before exiting the ER, all proteins undergo quality control such that only properly folded proteins transit to the Golgi and cell surface. The ER is also the site for sterol and lipid synthesis. As a major synthetic organelle, the ER is extremely sensitive to perturbations in homeostasis. Accumulation of misfolded or unfolded proteins within the ER induces a signaling pathway termed the unfolded protein response (UPR), which acts to restore ER homeostasis. This article discusses the basic mechanisms of protein folding in the ER, the role of the key ER chaperones, induction of the UPR, ER-associated degradation, and human diseases caused by protein misfolding and aggregation.

N. Naidoo

2011-01-01T23:59:59.000Z

355

Protein Folding Dynamics via Quantification of Kinematic Energy Landscape  

Science Journals Connector (OSTI)

We study folding dynamics of proteinlike sequences on a square lattice using a physical move set that exhausts all possible conformational changes. By analytically solving the master equation, we follow the time-dependent probabilities of occupancy of all 802?075 conformations of 16 mers over 7 orders of time span. We find that (i) folding rates of these proteinlike sequences of the same length can differ by 4 orders of magnitude, (ii) folding rates of sequences of the same conformation can differ by a factor of 190, and (iii) parameters of the native structures, designability, and thermodynamic properties are weak predictors of the folding rates; rather, a basin analysis of the kinematic energy landscape defined by the moves can provide an excellent account of the observed folding rates.

Sëma Kachalo; Hsiao-Mei Lu; Jie Liang

2006-02-08T23:59:59.000Z

356

Glottal opening in patients with vocal fold tissue changes  

Science Journals Connector (OSTI)

Summary Synchronized videostroboscopy and electroglottography were applied to the measurement of anterior-to-posterior open glottal length in four groups of patients; two with no clinically significant voice disorder, one with vocal fold polyps, and one with vocal fold nodules. The data showed that the groups did not differ significantly when open glottal length was measured at the time of minimum glottal opening. The pathological groups had significantly lower open glottal length measurements, however, when measurements were obtained at the time that vocal fold contact was initiated during the glottal cycle. The findings are preliminary evidence that vocal fold neoplasms may not have the effect of reducing glottal closure, as previously suggested in the literature. The data also highlight the importance of examining differential effects of vocal fold neoplasms at various points throughout the glottal cycle.

Michael P. Karnell; Ligang Li; William R. Panje

1991-01-01T23:59:59.000Z

357

Polymer uncrossing and knotting in protein folding, and their role in minimal folding pathways  

E-Print Network [OSTI]

We introduce a method for calculating the extent to which chain non-crossing is important in the most efficient, optimal trajectories or pathways for a protein to fold. This involves recording all unphysical crossing events of a ghost chain, and calculating the minimal uncrossing cost that would have been required to avoid such events. A depth-first tree search algorithm is applied to find minimal transformations to fold $\\alpha$, $\\beta$, $\\alpha/\\beta$, and knotted proteins. In all cases, the extra uncrossing/non-crossing distance is a small fraction of the total distance travelled by a ghost chain. Different structural classes may be distinguished by the amount of extra uncrossing distance, and the effectiveness of such discrimination is compared with other order parameters. It was seen that non-crossing distance over chain length provided the best discrimination between structural and kinetic classes. The scaling of non-crossing distance with chain length implies an inevitable crossover to entanglement-do...

Mohazab, Ali R

2012-01-01T23:59:59.000Z

358

New Crystal Structures Lift Fog around Protein Folding  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

New Crystal Structures Lift Fog around Protein Folding Print New Crystal Structures Lift Fog around Protein Folding Print Nature's proteins set a high bar for nanotechnology. Macromolecules forged from peptide chains of amino acids, these biomolecular nanomachines must first be folded into a dazzling variety of shapes and forms before they can perform the multitude of functions fundamental to life. However, the mechanisms behind the protein-folding process have remained a foggy mystery. Now the fog is lifting: a team of researchers from Berkeley Lab, Stanford University, and the Massachusetts Institute of Technology has deciphered the crystal structure of a critical control element within chaperonin, the protein complex responsible for the correct folding of other proteins. Chaperonins promote the proper folding of newly translated proteins and proteins that have been stress-denatured-meaning they've lost their structure-by encapsulating them inside a protective chamber formed from two rings of molecular complexes stacked back-to-back. There are two classes of chaperonins, group I found in prokaryotes and group II found in eukaryotes and archaea (organisms with no cell membrane or internal membrane-bound organelles). Much of the basic architecture has been evolutionarily preserved (conserved) across these two classes but they do differ in how the protective chamber is opened to accept proteins and closed to fold them. Whereas group I chaperonins require a detachable ring-shaped molecular lid to open and close the chamber, group II chaperonins have a built-in lid.

359

Criterion based Two Dimensional Protein Folding Using Extended GA  

E-Print Network [OSTI]

Abstract — In the dynamite field of biological and protein research, the protein fold recognition for long pattern protein sequences is a great confrontation for many years. With that consideration, this paper contributes to the protein folding research field and presents a novel procedure for mapping appropriate protein structure to its correct 2D fold by a concrete model using swarm intelligence. Moreover, the model incorporates Extended Genetic Algorithm (EGA) with concealed Markov model (CMM) for effectively folding the protein sequences that are having long chain lengths. The protein sequences are preprocessed, classified and then, analyzed with some parameters (criterion) such as fitness, similarity and sequence gaps for optimal formation of protein structures. Fitness correlation is evaluated for the determination of bonding strength of molecules, thereby involves in efficient fold recognition task. Experimental results have shown that the proposed method is more adept in 2D protein folding and outperforms the existing algorithms. Index Terms — classification, CMM, criterion analysis, EGA, protein folding, sequence gaps I.

T. Kalai Chelvi; P. Rangarajan

360

Physics of Caustics and Protein Folding: Mathematical Parallels  

E-Print Network [OSTI]

The energy for protein folding arises from multiple sources and is not large in total. In spite of the many specific successes of energy landscape and other approaches, there still seems to be some missing guiding factor that explains how energy from diverse small sources can drive a complex molecule to a unique state. We explore the possibility that the missing factor is in the geometry. A comparison of folding with other physical phenomena, together with analytic modeling of a molecule, led us to analyze the physics of optical caustic formation and of folding behavior side-by-side. The physics of folding and caustics is ostensibly very different but there are several strong parallels. This comparison emphasizes the mathematical similarity and also identifies differences. Since the 1970's, the physics of optical caustics has been developed to a very high degree of mathematical sophistication using catastrophe theory. That kind of quantitative application of catastrophe theory has not previously been applied to folding nor have the points of similarity with optics been identified or exploited. A putative underlying physical link between caustics and folding is a torsion wave of non-constant wave speed, propagating on the dihedral angles and $\\Psi$ found in an analytical model of the molecule. Regardless of whether we have correctly identified an underlying link, the analogy between caustic formation and folding is strong and the parallels (and differences) in the physics are useful.

Walter Simmons; Joel L. Weiner

2011-08-13T23:59:59.000Z

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361

Foreland signature of indenter tectonics: Insights from calcite twinning analysis in the Tennessee salient of the Southern Appalachians, USA  

Science Journals Connector (OSTI)

...paleomagnetic cores using a portable, gasoline-powered drill, and oriented...most accurate results, only straight, continuous twin sets were...twins are typically thin and straight. Unlike samples from the fold-and-thrust...indenter, which was seen in all runs of the experiment. Whereas...

James S. Hnat; Ben A. van der Pluijm

362

Distribution of arsenic, selenium, and other trace elements in high pyrite Appalachian coals: Evidence for multiple episodes of pyrite formation  

Science Journals Connector (OSTI)

Pennsylvanian coals in the Appalachian Basin host pyrite that is locally enriched in potentially toxic trace elements such as As, Se, Hg, Pb, and Ni. A comparison of pyrite-rich coals from northwestern Alabama, eastern Kentucky, and West Virginia reveals differences in concentrations and mode of occurrence of trace elements in pyrite. Pyrite occurs as framboids, dendrites, or in massive crystalline form in cell lumens or crosscutting veins. Metal concentrations in pyrite vary over all scales, from microscopic to mine to regional, because trace elements are inhomogeneously distributed in the different morphological forms of pyrite, and in the multiple generations of sulfide mineral precipitates. Early diagenetic framboidal pyrite is usually depleted in As, Se, and Hg, and enriched in Pb and Ni, compared to other pyrite forms. In dendritic pyrite, maps of As distribution show a chemical gradient from As-rich centers to As-poor distal branches, whereas Se concentrations are highest at the distal edges of the branches. Massive crystalline pyrite that fills veins is composed of several generations of sulfide minerals. Pyrite in late-stage veins commonly exhibits As-rich growth zones, indicating a probable epigenetic hydrothermal origin. Selenium is concentrated at the distal edges of veins. A positive correlation of As and Se in pyrite veins from Kentucky coals, and of As and Hg in pyrite-filled veins from Alabama coals, suggests coprecipitation of these elements from the same fluid. In the Kentucky coal samples (n = 18), As and Se contents in pyrite-filled veins average 4200 ppm and 200 ppm, respectively. In Alabama coal samples, As in pyrite-filled veins averages 2700 ppm (n = 34), whereas As in pyrite-filled cellular structures averages 6470 ppm (n = 35). In these same Alabama samples, Se averages 80 ppm in pyrite-filled veins, but was below the detection limit in cell structures. In samples of West Virginia massive pyrite, As averages 1700 ppm, and Se averages 270 ppm (n = 24). The highest concentration of Hg (? 102 ppm) is in Alabama pyrite veins. Improved detailed descriptions of sulfide morphology, sulfide mineral paragenesis, and trace-element concentration and distribution allow more informed predictions of: (1) the relative rate of release of trace elements during weathering of pyrite in coals, and (2) the relative effectiveness of various coal-cleaning procedures of removing pyrite. For example, trace element-rich pyrite has been shown to be more soluble than stoichiometric pyrite, and fragile fine-grained pyrite forms such as dendrites and framboids are more susceptible to dissolution and disaggregation but less amenable to removal during coal cleaning.

S.F. Diehl; M.B. Goldhaber; A.E. Koenig; H.A. Lowers; L.F. Ruppert

2012-01-01T23:59:59.000Z

363

An Appalachian-sourced deltaic sequence, northeastern Alabama, U.S.A.: biofacies-lithofacies relationships and interpreted community patterns  

Science Journals Connector (OSTI)

The thin sequence of Lowe Pennsylvania rocks along Sand Mountain, Plateau coal field, northeastern Alabama, U.S.A., records the deposition in a deltaic coastal-plain paleoenvironment along the ancient Appalachian seaway. The section is laterally continuous, well exposed, and preserves a rich macrobiota. Identified coexisting paleodepositional environments contain distinctive biofacies. Biofacies in deltaic sites are characterized by the presence of various macrofloral assemblages. Alluvial-plain swamps, identified lithologically by homogeneous mudstone and siltstone, preserve bedded-plant litter as coalified compressions and impressions. Deep-swamp biofacies are comprised either of monotypic lycophyte canopy assemblages (Lepidophloios) or their subterranean axial systems (Stigmaria). Alluvial swamps and proximal levee sites contain canopy detritus of a mixed flora. This is reflected in the reduced domination of Lepidophloios, the increased importance of the lycophytes Sigillaria and Lepidodendron, and an abundance of gymnosperms, pteridosperms, pteridophytes, and Calamites. Macro-invertebrates occur almost exclusively as behavioral trackways of xiphosurid arthropods and epifauna attached to fragmentary plant parts. The peat-accumulating swamp biofacies is identified from palynological preparations. Palynofloras parallel macrofloral clastic swamp diversity and contain an abundance of palynomorphs with affinities to ferns and lyginopterid pteridosperms. Channel-form sandstone represent distributary and crevasse channel deposits in the lower part of the section, and uncomformable bedload-dominated, laterally migrating, braided-river channel deposits at the top of the sequence. Oriented sandstone cast and compressed logs (lycophytes and Calamites) occur with bedload features in distributary and braided channels. Crevasse sanstones preserve a higher proportion of calamitean axes, as well as trunks and rachises of medullosan pteridosperms. Macro-invertebrates and ichnofaunas have not been identified in these paleoenvironments. Bayfill sequences contain several in situ macro-invertebrate communities in addition to allochthonous plant detritus. This plant biofacies is characterized by calamitean and pteridospermous vegetation, that originated from levee sites. The macrofaunal biofacies is characterized by a molluscan assemblage, with community replacement relative to physical parameters of the water. The initial bayfill phase contains an inarticulate brachiopod community of Orbiculoidea and Lingula. The transition to the molluscan-dominated biofacies is signaled by infaunal colonization by Pteronites and Planolites (burrows). Biotic changes are reflected by the increasing abundance of brachiopods and other invertebrates usually considered to represent more open-marine conditions. Insights into Late Carboniferous open-marine communities can be discerned from lag accumulations of marine epifauna in storm-generated sandstones.

Robert A. Gastaldo; Michael A. Gibson; Tony D. Gray

1989-01-01T23:59:59.000Z

364

Tectonophysics, 104 (1984) 299-313 Elsevier Science Publishers B.V., Amsterdam -Printed in The Netherlands  

E-Print Network [OSTI]

in The Netherlands 299 SURFACE MORPHOLOGY ON CROSS-FOLD JOINTS OF THE APPALACHIAN PLATEAU, NEW YORK AND PENNSYLVANIA

Engelder, Terry

365

Modeling two-state cooperativity in protein folding  

E-Print Network [OSTI]

A protein model with the pairwise interaction energies varying as local environment changes, i.e., including some kinds of collective effect between the contacts, is proposed. Lattice Monte Carlo simulations on the thermodynamical characteristics and free energy profile show a well-defined two-state behavior and cooperativity of folding for such a model. As a comparison, related simulations for the usual G\\={o} model, where the interaction energies are independent of the local conformations, are also made. Our results indicate that the evolution of interactions during the folding process plays an important role in the two-state cooperativity in protein folding.

K. Fan; J. Wang; W. Wang

2001-03-19T23:59:59.000Z

366

Protein folding bottlenecks: A lattice Monte Carlo simulation  

Science Journals Connector (OSTI)

Results of Monte Carlo simulations of folding of a model ‘‘protein,’’ which is a freely joined 27-monomer chain on a simple cubic lattice with nearest-neighbor interactions, are reported. All compact self-avoiding conformations on this chain have been enumerated, and the conformation (‘‘native’’) corresponding to the global minimum of energy is known for each sequence. Only one out of thirty sequences folds and finds the global minimum. For this sequence, the folding process has a two-stage character, with a rapid noncooperative compactization followed by a slower transition over a free-energy barrier to the global minimum. The evolutionary implications of the results are discussed.

E. Shakhnovich; G. Farztdinov; A. M. Gutin; M. Karplus

1991-09-16T23:59:59.000Z

367

Modeling two-state cooperativity in protein folding  

Science Journals Connector (OSTI)

A protein model with the pairwise interaction energies varying as the local environment changes, i.e., including some kind of collective effect between the contacts, is proposed. Lattice Monte Carlo simulations on the thermodynamical characteristics and free energy profile show a well-defined two-state behavior and cooperativity of folding for such a model. As a comparison, related simulations for the usual G? model, where the interaction energies are independent of the local conformation, are also made. Our results indicate that the evolution of interactions during the folding process plays an important role in the two-state cooperativity in protein folding.

Ke Fan; Jun Wang; Wei Wang

2001-09-21T23:59:59.000Z

368

Water dynamics clue to key residues in protein folding  

SciTech Connect (OSTI)

A computational method independent of experimental protein structure information is proposed to recognize key residues in protein folding, from the study of hydration water dynamics. Based on all-atom molecular dynamics simulation, two key residues are recognized with distinct water dynamical behavior in a folding process of the Trp-cage protein. The identified key residues are shown to play an essential role in both 3D structure and hydrophobic-induced collapse. With observations on hydration water dynamics around key residues, a dynamical pathway of folding can be interpreted.

Gao, Meng [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)] [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China); Zhu, Huaiqiu, E-mail: hqzhu@pku.edu.cn [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)] [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China); Yao, Xin-Qiu [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China) [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China); Department of Biophysics, Kyoto University, Sakyo Kyoto 606-8502 (Japan); She, Zhen-Su, E-mail: she@pku.edu.cn [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)] [State Key Laboratory for Turbulence and Complex Systems, and Department of Biomedical Engineering, and Center for Theoretical Biology, and Center for Protein Science, Peking University, Beijing 100871 (China)

2010-01-29T23:59:59.000Z

369

Computational investigations of folded self-avoiding walks related to protein folding  

E-Print Network [OSTI]

Various subsets of self-avoiding walks naturally appear when investigating existing methods designed to predict the 3D conformation of a protein of interest. Two such subsets, namely the folded and the unfoldable self-avoiding walks, are studied computationally in this article. We show that these two sets are equal and correspond to the whole $n$-step self-avoiding walks for $n\\leqslant 14$, but that they are different for numerous $n \\geqslant 108$, which are common protein lengths. Concrete counterexamples are provided and the computational methods used to discover them are completely detailed. A tool for studying these subsets of walks related to both pivot moves and proteins conformations is finally presented.

Bahi, Jacques M; Mazouzi, Kamel; Philippe, Laurent

2013-01-01T23:59:59.000Z

370

Investigation of Peptide Folding by Nuclear Magnetic Resonance Spectroscopy  

E-Print Network [OSTI]

. Solution-state nuclear magnetic resonance (NMR) is a powerful technique to investigate protein structure, dynamics, and folding mechanisms, since it provides residue-specific information. One of the major contributions that govern protein structure appears...

Hwang, SoYoun

2012-07-16T23:59:59.000Z

371

Protein folding in the secretory pathway of animal cells  

Science Journals Connector (OSTI)

The exit of newly-synthesized proteins from the lumen of the endoplasmic reticulum (ER) is the rate-determining step in protein secretion. Only correctly-folded and fully-assembled proteins exit the ER and pro...

Robert B. Freedman; Carole Greenall; Nigel Jenkins; Mick F. Tuite

1995-01-01T23:59:59.000Z

372

Office of Small and Disadvantaged Business Utilization Tri-Fold  

Broader source: Energy.gov [DOE]

OSDBU has created a downloadable, print-on-demand tri-fold PDF that introduces the office, its role in the Department of Energy and its goals for supporting small business nationwide.

373

Determining the role of hydration forces in protein folding  

SciTech Connect (OSTI)

One of the primary issues in protein folding is determining what forces drive folding and eventually stabilize the native state. A delicate balance exists between electrostatic forces such as hydrogen bonding and salt bridges, and the hydrophobic effect, which are present for both intramolecular protein interactions and intermolecular contributions with the surrounding aqueous environment. This article describes a combined experimental, theoretical, and computational effort to show how the complexity of aqueous hydration can influence the structure, folding and aggregation, and stability of model protein systems. The unification of the theoretical and experimental work is the development or discovery of effective amino acid interactions that implicitly include the effects of aqueous solvent. The authors show that consideration of the full range of complexity of aqueous hydration forces such as many-body effects, long-ranged character of aqueous solvation, and the assumptions made about the degree of protein hydrophobicity can directly impact the observed structure, folding, and stability of model protein systems.

Sorenson, J.M. [Univ. of California, Berkeley, CA (United States). Dept. of Chemistry] [Univ. of California, Berkeley, CA (United States). Dept. of Chemistry; Hura, G. [Univ. of California, Berkeley, CA (United States)] [Univ. of California, Berkeley, CA (United States); [Lawrence Berkeley National Lab., CA (United States). Life Sciences Div.; Soper, A.K. [Rutherford Appleton Lab., Didcot (United Kingdom). ISIS Facility] [Rutherford Appleton Lab., Didcot (United Kingdom). ISIS Facility; Pertsemlidis, A. [Univ. of Texas Southwestern Medical Center, Dallas, TX (United States). Dept. of Biochemistry] [Univ. of Texas Southwestern Medical Center, Dallas, TX (United States). Dept. of Biochemistry; Head-Gordon, T. [Lawrence Berkeley National Lab., CA (United States)] [Lawrence Berkeley National Lab., CA (United States)

1999-07-01T23:59:59.000Z

374

Low energy pathways for reproducible in vivo protein folding  

E-Print Network [OSTI]

Two proteins, one belonging to the mainly alpha class and the other belonging to the alpha/beta class, are selected to test a kinetic mechanism for protein folding. Targeted molecular dynamics is applied to generate folding pathways for those two proteins, starting from two well defined initial conformations: a fully extended and a alpha-helical conformation. The results show that for both proteins the alpha-helical initial conformation provides overall lower energy pathways to the native state. For the alpha/beta protein, 30 % (40%) of the pathways from an initial alpha-helix (fully extended) structure lead to unentangled native folds, a success rate that can be increased to 85 % by the introduction of a well-defined intermediate structure. These results open up a new direction in which to look for a solution to the protein folding problem, as detailed at the end.

Leonor Cruzeiro

2011-01-03T23:59:59.000Z

375

Physics of Caustics and Protein Folding: Mathematical Parallels  

E-Print Network [OSTI]

The energy for protein folding arises from multiple sources and is not large in total. In spite of the many specific successes of energy landscape and other approaches, there still seems to be some missing guiding factor that explains how energy from diverse small sources can drive a complex molecule to a unique state. We explore the possibility that the missing factor is in the geometry. A comparison of folding with other physical phenomena, together with analytic modeling of a molecule, led us to analyze the physics of optical caustic formation and of folding behavior side-by-side. The physics of folding and caustics is ostensibly very different but there are several strong parallels. This comparison emphasizes the mathematical similarity and also identifies differences. Since the 1970's, the physics of optical caustics has been developed to a very high degree of mathematical sophistication using catastrophe theory. That kind of quantitative application of catastrophe theory has not previously been applied ...

Simmons, Walter

2011-01-01T23:59:59.000Z

376

Mechanisms of protein-folding diseases at a glance  

E-Print Network [OSTI]

For a protein to function appropriately, it must first achieve its proper conformation and location within the crowded environment inside the cell. Multiple chaperone systems are required to fold proteins correctly. In ...

Valastyan, Julie Suzanne

377

INTRODUCTION Lateral propagation of folds is a process in  

E-Print Network [OSTI]

; (2) decrease in elevation of wind gaps; (3) decrease in relief of the topographic profile along in rotation and inclination of the forelimb. As a result of style of folding and variable geomorphic response

Keller, Ed

378

Master equation approach to protein folding and kinetic traps  

E-Print Network [OSTI]

The master equation for 12-monomer lattice heteropolymers is solved numerically and the time evolution of the occupancy of the native state is determined. At low temperatures, the median folding time follows the Arrhenius law and is governed by the longest relaxation time. For good folders, significant kinetic traps appear in the folding funnel whereas for bad folders, the traps also occur in non-native energy valleys.

Marek Cieplak; Malte Henkel; Jan Karbowski; Jayanth R. Banavar

1998-04-21T23:59:59.000Z

379

Unfolded protein ensembles, folding trajectories, and refolding rate prediction  

Science Journals Connector (OSTI)

Computer simulations can provide critical information on the unfolded ensemble of proteins under physiological conditions by explicitly characterizing the geometrical properties of the diverse conformations that are sampled in the unfolded state. A general computational analysis across many proteins has not been implemented however. Here we develop a method for generating a diverse conformational ensemble to characterize properties of the unfolded states of intrinsically disordered or intrinsically folded proteins. The method allows unfolded proteins to retain disulfide bonds. We examined physical properties of the unfolded ensembles of several proteins including chemical shifts clustering properties and scaling exponents for the radius of gyration with polymer length. A problem relating simulated and experimental residual dipolar couplings is discussed. We apply our generated ensembles to the problem of folding kinetics by examining whether the ensembles of some proteins are closer geometrically to their folded structures than others. We find that for a randomly selected dataset of 15 non-homologous 2- and 3-state proteins quantities such as the average root mean squared deviation between the folded structure and unfolded ensemble correlate with folding rates as strongly as absolute contact order. We introduce a new order parameter that measures the distance travelled per residue which naturally partitions into a smooth “laminar” and subsequent “turbulent” part of the trajectory. This latter conceptually simple measure with no fitting parameters predicts folding rates in 0 M denaturant with remarkable accuracy (r = ?0.95 p = 1 × 10?7). The high correlation between folding times and sterically modulated reconfigurational motion supports the rapid collapse of proteins prior to the transition state as a generic feature in the folding of both two-state and multi-state proteins. This method for generating unfolded ensembles provides a powerful approach to address various questions in protein evolution misfolding and aggregation transient structures and molten globule and disordered protein phases.

2013-01-01T23:59:59.000Z

380

NEP for a Kuiper Belt Object Rendezvous Mission  

SciTech Connect (OSTI)

Kuiper Belt Objects (KBOs) are a recently-discovered set of solar system bodies which lie at about the orbit of Pluto (40 AU) out to about 100 astronomical units (AU). There are estimated to be about 100,000 KBOS with a diameter greater than 100 km. KBOS are postulated to be composed of the pristine material which formed our solar system and may even have organic materials in them. A detailed study of KBO size, orbit distribution, structure, and surface composition could shed light on the origins of the solar system and perhaps even on the origin of life in our solar system. A rendezvous mission including a lander would be needed to perform chemical analysis of the surface and sub-surface composition of KBOS. These requirements set the size of the science probe at around a ton. Mission analyses show that a fission-powered system with an electric thruster could rendezvous at 40 AU in about 13.0 years with a total {Delta}V of 46 krnk. It would deliver a 1000-kg science payload while providing ample onboard power for relaying data back to earth. The launch mass of the entire system (power, thrusters, propellant, navigation, communication, structure, science payload, etc.) would be 7984 kg if it were placed into an earth-escape trajectory (C=O). Alternatively, the system could be placed into a 700-km earth orbit with more propellant,yielding a total mass in LEO of 8618 kg, and then spiral out of earth orbit to arrive at the KBO in 14.3 years. To achieve this performance, a fission power system with 100 kW of electrical power and a total mass (reactor, shield, conversion, and radiator) of about 2350 kg. Three possible configurations are proposed: (1) a UZrH-fueled, NaK-cooled reactor with a steam Rankine conversion system, (2) a UN-fueled gas-cooled reactor with a recuperated Brayton conversion system, and (3) a UN-fueled heatpipe-cooled reactor with a recuperated Brayton conversion system. (Boiling and condensation in the Rankine system is a technical risk at present.) All three of these systems have the potential to meet the weight requirement for the trip and to be built in the near term.

HOUTS,MICHAEL G.; LENARD,ROGER X.; LIPINSKI,RONALD J.; PATTON,BRUCE; POSTON,DAVID I.; WRIGHT,STEVEN A.

1999-11-03T23:59:59.000Z

Note: This page contains sample records for the topic "appalachian fold belt" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Speeding up protein folding: mutations that increase the rate at which Rop folds and unfolds by over four orders of magnitude  

E-Print Network [OSTI]

Speeding up protein folding: mutations that increase the rate at which Rop folds and unfolds. Introduction When a protein folds, the backbone and sidechain atoms organize from the extensive number protein folding usually occurs on the order of milliseconds to seconds, it is gener- ally accepted

Mochrie, Simon

382

Using Bit-Vector Decision Procedures for Analysis of Protein Folding Pathways  

E-Print Network [OSTI]

Using Bit-Vector Decision Procedures for Analysis of Protein Folding Pathways Christopher James-vector decision procedures for the analysis of protein folding pathways. We argue that the protein fold- ing by the different nature of the protein folding problem, we present a translation of the protein folding pathways

Langmead, Christopher James

383

DOI: 10.1002/ijch.201300141 Exploring the Protein Folding Dynamics of Beta3s with  

E-Print Network [OSTI]

DOI: 10.1002/ijch.201300141 Exploring the Protein Folding Dynamics of Beta3s with Two folding process. Howev- er, monitoring protein folding dynamics is still challeng- ing. Experiments of protein folding. However, most folding processes of interest occur on timescales (microsecond to second

Mukamel, Shaul

384

RoadmapMethodsforProteinFolding MarkMoll, DavidSchwarz, LydiaE.Kavraki  

E-Print Network [OSTI]

RoadmapMethodsforProteinFolding MarkMoll, DavidSchwarz, LydiaE.Kavraki Abstract--Protein folding, and get a coarse view of the energy landscape. Keywords: protein folding, folding kinetics, roadmap methods, conformation sampling techniques, energy landscape. 1 Introduction Protein folding refers

Kavraki, Lydia E.

385

Protein Quaternary Fold Recognition Using Conditional Graphical Models Yan Liu Jaime Carbonell  

E-Print Network [OSTI]

02139 pweigele@mit.edu Abstract Protein fold recognition is a crucial step in infer- ring biological- acid sequences is protein fold recognition and alignment. Given a target protein fold 1 , the task-to-topology alignment against the fold. There are different kinds of protein folds based on their structural properties

Carbonell, Jaime

386

Kinetic Studies of the Folding of Heterodimeric Monellin: Evidence for Switching between Alternative  

E-Print Network [OSTI]

Keywords: monellin; heterodimeric protein; folding kinetics; parallel pathways Determining whether or not a protein uses multiple pathways to fold is an important goal in protein folding studies. When multiple to the protein folding reaction, and the utilization of more than one pathway would speed protein folding.2

387

A multi-camera vision system for real-time tracking of parcels moving on a conveyor belt  

Science Journals Connector (OSTI)

We consider the problem of designing a vision system for tracking parcels moving on a conveyor belt. After computing parcels dimensions, i.e., length, width and height, at the entrance of the conveyor belt using a stereo camera pair, the vision system ...

Hüseyin N. Karaca; Cüneyt Ak?nlar

2005-10-01T23:59:59.000Z

388

Tellurides, selenides and Bi-mineral assemblages from the Río Narcea Gold Belt, Asturias, Spain: genetic implications in Cu–Au and Au skarns  

Science Journals Connector (OSTI)

Gold ores in skarns from the Río Narcea Gold Belt are associated with Bi–Te(–Se)-bearing minerals. These mineral assemblages have been used to compare two different skarns from this belt, a Cu–Au skarn (calcic...

A. Cepedal; M. Fuertes-Fuente; A. Martín-Izard…

2006-07-01T23:59:59.000Z

389

Detection and characterization of partially folded forms on the protein energy landscape  

E-Print Network [OSTI]

can accelerate protein folding. Proc Natl Acad Sci U S A 96(coupling between protein folding and prolyl isomerization.The speed limit for protein folding measured by triplet-

Bernstein, Rachel Simma

2011-01-01T23:59:59.000Z

390

On the Complexity of Protein Folding Pierluigi Crescenzi, Deborah Goldman, Christos Papadimitriou  

E-Print Network [OSTI]

On the Complexity of Protein Folding Pierluigi Crescenzi, Deborah Goldman, Christos Papadimitriou Antonio Piccolboni, Mihalis Yannakakis Abstract We show that the protein folding problem in the two protein folding are the interactions between their monomers; recently, the view that non

California at Irvine, University of

391

Long-time protein folding dynamics from short-time molecular dynamics simulations  

E-Print Network [OSTI]

On the simulation of protein folding by short time scaleand W. A. Eaton, The protein folding “speed limit,” Curr.and T. Head-Gordon, Protein folding by distributed computing

Chodera, J D; Swope, W C; Pitera, J W; Dill, Ken A

2006-01-01T23:59:59.000Z

392

Crucial stages of protein folding through a solvable model: Predicting target sites  

E-Print Network [OSTI]

Crucial stages of protein folding through a solvable model: Predicting target sites for enzyme. Keywords: Protein-folding modeling; prediction of key folding sites; HIV-1 protease; drug resistance One

Cecconi, Fabio

393

Parallel ContinuationBased Global Optimization for Molecular Conformation and Protein Folding  

E-Print Network [OSTI]

Parallel Continuation­Based Global Optimization for Molecular Conformation and Protein Folding protein folding. Global minimization problems are difficult to solve when the objective functions have energy functions for molecular conformation and protein folding. Mathematical theory for the method

Neumaier, Arnold

394

Restoring Sustainable Forests on Appalachian Mined Lands for Wood Products, Renewable Energy, Carbon Sequestration, and Other Ecosystem Services  

SciTech Connect (OSTI)

The overall purpose of this project is to evaluate the biological and economic feasibility of restoring high-quality forests on mined land, and to measure carbon sequestration and wood production benefits that would be achieved from forest restoration procedures. We are currently estimating the acreage of lands in Virginia, West Virginia, Kentucky, Ohio, and Pennsylvania mined under SMCRA and reclaimed to non-forested post-mining land uses that are not currently under active management, and therefore can be considered as available for carbon sequestration. To determine actual sequestration under different forest management scenarios, a field study was installed as a 3 x 3 factorial in a random complete block design with three replications at each of three locations, one each in Ohio, West Virginia, and Virginia. The treatments included three forest types (white pine, hybrid poplar, mixed hardwood) and three silvicultural regimes (competition control, competition control plus tillage, competition control plus tillage plus fertilization). Each individual treatment plot is 0.5 acres. Each block of nine plots is 4.5 acres, and the complete installation at each site is 13.5 acres. During the reporting period we determined that by grinding the soil samples to a finer particle size of less than 250 ?m (sieve No. 60), the effect of mine soil coal particle size on the extent to which these particles will be oxidized during the thermal treatment of the carbon partitioning procedure will be eliminated, thus making the procedure more accurate and precise. In the second phase of the carbon sequestration project, we focused our attention on determining the sample size required for carbon accounting on grassland mined fields in order to achieve a desired accuracy and precision of the final soil organic carbon (SOC) estimate. A mine land site quality classification scheme was developed and some field-testing of the methods of implementation was completed. The classification model has been validated for softwoods (white pine) on several reclaimed mine sites in the southern Appalachian coal region. The classification model is a viable method for classifying post-SMCRA abandoned mined lands into productivity classes for white pine. A thinning study was established as a random complete block design to evaluate the response to thinning of a 26-year-old white pine stand growing on a reclaimed surface mine in southwest Virginia. Stand parameters were projected to age 30 using a stand table projection. Site index of the stand was found to be 32.3 m at base age 50 years. Thinning rapidly increased the diameter growth of the residual trees to 0.84 cm yr{sup -1} compared to 0.58 cm yr{sup -1} for the unthinned treatment; however, at age 26, there was no difference in volume or value per hectare. At age 30, the unthinned treatment had a volume of 457.1 m{sup 3} ha{sup -1} but was only worth $8807 ha{sup -1}, while the thinned treatment was projected to have 465.8 m{sup 3} ha{sup -1}, which was worth $11265 ha{sup -1} due to a larger percentage of the volume being in sawtimber size classes.

James A. Burger

2005-07-20T23:59:59.000Z

395

An Appalachian-sourced deltaic sequence, northeastern Alabama, USA: biofacies-lithofacies relationships and interpreted community patterns  

Science Journals Connector (OSTI)

The thin sequence of Lower Pennsylvania rocks along Sand Mountain, Plateau coal field, northeastern Alabama, U.S.A., records the deposition in a deltaic coastal-plain paleoenvironment along the ancient Appalachian seaway. The section is laterally continuous, well exposed, and preserves a rich macrobiota. Identified coexisting paleodepositional environments contain distinctive biofacies. Specific paleoenvironments of deposition contain unique biofacies in this Late Carboniferous (Westphalian A) sequence. The criteria established for the recognition of these biofacies can be utilized to assist in refined interpretations of deltaic sites in Carboniferous coastal paleoenvironments. Identifiable biofacies include those preserved under a variety of forested wetland (swamp) conditions, distributary and crevasse-splay channels, coastal bays (“interdistributary” and lagoonal), barrier sands, and distal storm deposits (Fig. 1; Gastaldo et al., 1989). Vegetation in forested wetlands grew either in clastic substrates or peat substrates. The principal biofacies preserved in clastic substrate swamps were lycophyte-dominated, and can be recognized by either a predominance of canopy litter or subterranean stigmarian appendages (Gastaldo, 1986). The canopy litter that has accumulated on the forest floor was preserved under unique sedimentological conditions, and reflects the ecological gradient associated with the distribution of lycophyte genera in the swamp (Gastaldo, 1987). A monotypic assemblage of lycophytes characterized edaphically stressed sites. In sites proximal to the levee, a mixed assemblage of lycophytes, calamiteans, pteridophytes and pteridosperms is common. In the absence of compressed canopy macrodetritus, subterranean axes with helically arranged appendages (“rootlets”) crosscutting the bedding may be preserved. Macro-invertebrates are restricted to traces and trails, reflecting behavioral traits when conditions were conducive for their movement into these sites. Peat-colonizing vegetation parallels that of the clastic swamp. Deep distributary channels contain sandstone-cast and compressed aerial trunks of lycophytes and spenophytes. These occur in bedload deposits along with quartz and quartzose pebbles and cobble-size phyllite clasts. Degradation of external morphology usually precludes assignment of logs to a systematic position lower than order. In shallower, en-echelon stacked crevasse sands occur a mixture of lycophyte, calamitean and pteridosperm “woody” parts. Additionally, scoriaceous fern-like foliage may be found. Little evidence exists for macro-invertebrate communities in these unstable settings. Coastal bays preserve in situ macro-invertebrate communities, as well as allochthonous macrodetritus that was derived principally from levee vegetation. Four phases of biofacies development can be delineated (Gibson and Gastaldo, 1987). Stress-tolerant inarticulate brachiopods dominate the initial transgressive phase. Individuals are found isolated in the siltstone, commonly preserved by authigenic cementation in siderite concretions. Rarely are patches or clusters of individual encountered. Where clustering does occur it is associated with the colonization of “woody” plant parts. Transition to the molluscan-dominated phase is accompanied by the establishment of a rich ichnofauna. Continued transgression and the development of more normal salinities under lagoonal conditions are paralleled by an increase in species richness and abundance. The third biofacies phase remains molluscan dominated, but the assemblages at any particular point in time are represented by monospecific genera. Plant macrodetritus was utilized by the macro-invertebrate communities, and that which is preserved is restricted to highly fragmentary, unindentifiable remains. The fourth biofacies phase reflects the development of lagoonal conditions. This change can be recognized by macro-invertebrate body and ichnofossil fauna (Seilacher's Cruziana ichnofacies) diversification. An increase in the abundance of brachiopods and other

R.A. Gastaldo; M.A. Gibson; T.D. Gray

1990-01-01T23:59:59.000Z

396

Intermediates and the folding of proteins L and G  

SciTech Connect (OSTI)

We use a minimalist protein model, in combination with a sequence design strategy, to determine differences in primary structure for proteins L and G that are responsible for the two proteins folding through distinctly different folding mechanisms. We find that the folding of proteins L and G are consistent with a nucleation-condensation mechanism, each of which is described as helix-assisted {beta}-1 and {beta}-2 hairpin formation, respectively. We determine that the model for protein G exhibits an early intermediate that precedes the rate-limiting barrier of folding and which draws together misaligned secondary structure elements that are stabilized by hydrophobic core contacts involving the third {beta}-strand, and presages the later transition state in which the correct strand alignment of these same secondary structure elements is restored. Finally the validity of the targeted intermediate ensemble for protein G was analyzed by fitting the kinetic data to a two-step first order reversible reaction, proving that protein G folding involves an on-pathway early intermediate, and should be populated and therefore observable by experiment.

Brown, Scott; Head-Gordon, Teresa

2003-07-01T23:59:59.000Z

397

Folding of a DNA Hairpin Loop Structure in Explicit SolventUsingRepli...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Folding of a DNA Hairpin Loop Structure in Explicit Solvent UsingReplica-Exchange Molecular Dynamics Simulations. Folding of a DNA Hairpin Loop Structure in Explicit Solvent...

398

Directed Evolution Designed to Optimize the in vivo Protein Folding Environment.  

E-Print Network [OSTI]

??Protein folding is assisted by molecular chaperones and folding catalysts in vivo. Understanding how chaperones are regulated and how they function in vivo may provide… (more)

Quan, Shu

2010-01-01T23:59:59.000Z

399

E-Print Network 3.0 - assisted protein folding Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

protein folding Search Powered by Explorit Topic List Advanced Search Sample search results for: assisted protein folding Page: << < 1 2 3 4 5 > >> 1 BIOLOGICAL FRAMEWORKS FOR...

400

E-Print Network 3.0 - ab initio folding Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

fold recogniion Ab initio Methods... Methods Ab initio methods: solution of a protein folding problem search in conformational space Energy... Protein Structure Analysis...

Note: This page contains sample records for the topic "appalachian fold belt" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

E-Print Network 3.0 - acids detection folding Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Medicine 4 International Scientific Conference Computer Science'2008 Near-Native Protein Folding Summary: folded proteins generally have polar amino acids on the outside of their...

402

SciTech Connect: Protein-folding via divide-and-conquer optimization  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Protein-folding via divide-and-conquer optimization Citation Details In-Document Search Title: Protein-folding via divide-and-conquer optimization Authors: Oliva, Ricardo;...

403

Topological Aspects of DNA Function and Protein Folding 523 Knotting pathways in proteins  

E-Print Network [OSTI]

Topological Aspects of DNA Function and Protein Folding 523 Knotting pathways in proteins Joanna I Key words: artificial knot, chaperone, free energy landscape, knotted protein, protein folding

Bigelow, Stephen

404

E-Print Network 3.0 - affecting protein folding Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

protein folding Search Powered by Explorit Topic List Advanced Search Sample search results for: affecting protein folding Page: << < 1 2 3 4 5 > >> 1 Current status of membrane...

405

High-temperature deformation in the Neoproterozoic transpressional Ribeira belt, southeast Brazil  

E-Print Network [OSTI]

High-temperature deformation in the Neoproterozoic transpressional Ribeira belt, southeast Brazil^ncias da Universidade de Sa~o Paulo, Rua do Lago 562, Cep: 05508-080, Sa~o Paulo, SP, Brazil b Laboratoire Geologia, Universidade Federal de Ouro Preto, 35400-000, Ouro Pre^to, MG, Brazil Received 5 April 2001

Bascou, Jérôme

406

Analysis of Heavy Oil Recovery by Thermal EOR in a Meander Belt: From Geological  

E-Print Network [OSTI]

Analysis of Heavy Oil Recovery by Thermal EOR in a Meander Belt: From Geological to Reservoir Energies nouvelles2 INTRODUCTION SAGD will become increasingly important for heavy oil recovery because assessment, well placement and production performance prediction. One of the most famous heavy oil provinces

Paris-Sud XI, Université de

407

AGRONOMIC ADVANCES IN THE AGRICULTURE OF THE CORN BELT AND THE GREAT PLAINS REGIONS  

Science Journals Connector (OSTI)

...THE AGRICULTURE OF THE CORN BELT AND THE GREAT PLAINS...to conduct the various milling and baking studies using...significant tie-up with the milling interests. In the spring...coopera-tion of the milling interests in the testing...Previous to the placing of corn improvement on a definite...

H. K. WILSON

1944-06-23T23:59:59.000Z

408

Pitch angle distribution analysis of radiation belt electrons based on Combined Release and Radiation Effects Satellite  

E-Print Network [OSTI]

Pitch angle distribution analysis of radiation belt electrons based on Combined Release of pitch angle distributions (PADs) of energetic electrons is performed. The distributions are classified a is the local pitch angle, a profile of the parameter n versus L-shell is produced for local times corresponding

Li, Xinlin

409

Seismic imaging of the lithospheric structure of the Zagros mountain belt (Iran)  

E-Print Network [OSTI]

Seismic imaging of the lithospheric structure of the Zagros mountain belt (Iran) ANNE PAUL1*, DENIS International Institute of Earthquake Engineering and Seismology, Tehran, Iran 3 Institute for Advanced Studies in Basic Sciences (IASBS), PO Box 45195-1159, Zanjan, Iran *Corresponding author (e-mail: Anne

Hatzfeld, Denis

410

Seismological evidence for crustal-scale thrusting in the Zagros mountain belt (Iran)  

E-Print Network [OSTI]

Seismological evidence for crustal-scale thrusting in the Zagros mountain belt (Iran) Anne Paul 1 Grenoble Cedex, France 2 International Institute of Earthquake Engineering and Seismology, Tehran, Iran 3 that the crust of Zagros underthrusts the crust of central Iran along the MZT considered as a crustal

Paris-Sud XI, Université de

411

Protein Folding Kinetics and Thermodynamics from Atomistic Simulations  

Science Journals Connector (OSTI)

Determining protein folding kinetics and thermodynamics from all-atom molecular dynamics (MD) simulations without using experimental data represents a formidable scientific challenge because simulations can easily get trapped in local minima on rough free energy landscapes. This necessitates the computation of multiple simulation trajectories, which can be independent from each other or coupled in some manner, as, for example, in the replica exchange MD method. Here we present results obtained with a new analysis tool that allows the deduction of faithful kinetics data from a heterogeneous ensemble of simulation trajectories. The method is demonstrated on the decapeptide Chignolin for which we predict folding and unfolding time constants of 1.0±0.3 and 2.6±0.4???s, respectively. We also derive the energetics of folding, and calculate a realistic melting curve for Chignolin.

David van der Spoel and M. Marvin Seibert

2006-06-15T23:59:59.000Z

412

Collective aspects of protein folding illustrated by a toy model  

SciTech Connect (OSTI)

A simple toy model for polypeptides serves as a testbed to illuminate some nonlocal, or collective, aspects of protein folding phenomena. The model is two dimensional and has only two amino acids, but involves a continuous range of backbone bend angles. Global potential energy minima and their folding structures have been determined for leading members of two special and contrasting polypeptide sequences, center doped and Fibonacci, named descriptively for their primary structures. The results display the presence of spontaneous symmetry breaking, elastic strain, and substantial conformational variation for specific embedded amino acid strings. We conclude that collective variables generated by the primary amino acid structure may be required for fully effective protein folding predictors, including those based on neural networks.

Stillinger, F.H. [AT& T Bell Laboratories, Murray Hill, New Jersey 07974 (United States)] [AT& T Bell Laboratories, Murray Hill, New Jersey 07974 (United States); Head-Gordon, T. [Life Sciences Division, Lawrence Berkeley Laboratory, University of California, Berkeley, California 94720 (United States)] [Life Sciences Division, Lawrence Berkeley Laboratory, University of California, Berkeley, California 94720 (United States)

1995-09-01T23:59:59.000Z

413

Heteropolymer freezing and design: Towards physical models of protein folding  

SciTech Connect (OSTI)

Protein folding has become one of the most actively studied problems in modern molecular biophysics. Approaches to the problem combine ideas from the physics of disordered systems, polymer physics, and molecular biology. Much can be learned from the statistical properties of model heteropolymers, the chain molecules having different monomers in irregular sequences. Even in highly evolved proteins, there is a strong random element in the sequences, which gives rise to a statistical ensemble of sequences for a given folded shape. Simple analytic models give rise to phase transitions between random, glassy, and folded states, depending on the temperature T and the design temperature T{sup des} of the ensemble of sequences. Besides considering the analytic results obtainable in a random-energy model and in the Flory mean-field model of polymers, the article reports on confirming numerical simulations. (c) 2000 The American Physical Society.

Pande, Vijay S. [Chemistry Department, Stanford University, Stanford, California 94305-5080 (United States)] [Chemistry Department, Stanford University, Stanford, California 94305-5080 (United States); Grosberg, Alexander Yu. [Department of Physics, University of Minnesota, Minneapolis, Minnesota 55455 (United States)] [Department of Physics, University of Minnesota, Minneapolis, Minnesota 55455 (United States); Tanaka, Toyoichi [Department of Physics and Center for Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States)] [Department of Physics and Center for Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States)

2000-01-01T23:59:59.000Z

414

PENNSYLVANIA APPALACHIAN LABORATORY  

E-Print Network [OSTI]

. Planning Principles 10 4. Sustainable Design Goals and Initiatives 13 5. Major Capital Projects 15 #12;R knowledge through scientific discovery, integration, application, and teaching, that results in a comprehensive understanding of our environment and natural resources, helping to guide the State and world

Boynton, Walter R.

415

SHuffle, a novel Escherichia coli protein expression strain capable of correctly folding disulfide bonded proteins in its cytoplasm  

E-Print Network [OSTI]

Schein CH: Optimizing protein folding to the native state inJ, Terwilliger TC: Rapid protein-folding assay using greenbuilding bridges in protein folding. Trends Biochem Sci

Lobstein, Julie; Emrich, Charlie A; Jeans, Chris; Faulkner, Melinda; Riggs, Paul; Berkmen, Mehmet

2012-01-01T23:59:59.000Z

416

The effect of consensus mutation on the folding and binding kinetics of I(kappa)B(alpha)  

E-Print Network [OSTI]

in the transition state of protein folding: alternativeet al. (2008). "Protein folding and stability usingto enzyme catalysis and protein folding. New York, W.H.

DeVries, Ingrid L.

2011-01-01T23:59:59.000Z

417

The role of the energy gap in protein folding dynamics  

E-Print Network [OSTI]

The dynamics of folding of proteins is studied by means of a phenomenological master equation. The energy distribution is taken as a truncated exponential for the misfolded states plus a native state sitting below the continuum. The influence of the gap on the folding dynamics is studied, for various models of the transition probabilities between the different states of the protein. We show that for certain models, the relaxation to the native state is accelerated by increasing the gap, whereas for others it is slowed down .

Estelle Pitard; Henri Orland

1998-11-17T23:59:59.000Z

418

Characterization of Protein Folding by Dominant Reaction Pathways  

E-Print Network [OSTI]

We assess the reliability of the recently developed approach denominated Dominant Reaction Pathways (DRP) by studying the folding of a 16-residue beta-hairpin, within a coarse-grained Go-type model. We show that the DRP predictions are in quantitative agreement with the results of Molecular Dynamics simulations, performed in the same model. On the other hand, in the DRP approach, the computational difficulties associated to the decoupling of time scales are rigorously bypassed. The analysis of the important transition pathways supports a picture of the beta-hairpin folding in which the reaction is initiated by the collapse of the hydrophobic cluster.

Pietro Faccioli

2008-06-23T23:59:59.000Z

419

Origin of the Native Driving Force for Protein Folding  

Science Journals Connector (OSTI)

We derive an expression with four adjustable parameters that reproduces well the 20×20 Miyazawa-Jernigan potential matrix extracted from known protein structures. The numerical values of the parameters can be approximately computed from the surface tension of water, water-screened dipole interactions between residues and water and among residues, and average exposures of residues in folded proteins.

Zi-Hao Wang and H. C. Lee

2000-01-17T23:59:59.000Z

420

Thermodynamics of Protein Folding from Coarse-Grained Models' Perspectives  

E-Print Network [OSTI]

Folding and aggregation of proteins, the interaction between proteins and membranes, as well as the adsorption of organic soft matter to inorganic solid substrates belong to the most interesting challenges in understanding structure and function of complex macromolecules. This is reasoned by the interdisciplinary character of the associated questions ranging from the molecular origin of the loss of biological functionality as, for example, in Alzheimer's disease to the development of organic circuits for biosensory applications. In this lecture, we focus on the analysis of mesoscopic models for protein folding, aggregation, and hybrid systems of soft and solid condensed matter. The simplicity of the coarse-grained models allows for a more universal description of the notoriously difficult problem of protein folding. In this approach, classifications of structure formation processes with respect to the conformational pseudophases are possible. This is similar in aggregation and adsorption processes, where the individual folding propensity is influenced by external forces. The main problem in studies of conformational transitions is that the sequences of amino acids proteins are built up of are necessarily of finite length and, therefore, a thermodynamic limit does not exist. Thus, structural transitions are not phase transitions in the strict thermodynamic sense and the analysis of pseudouniversal aspects is intricate, as apparently small-system effects accompany all conformational transitions and cannot be neglected.

Michael Bachmann; Wolfhard Janke

2007-10-25T23:59:59.000Z

Note: This page contains sample records for the topic "appalachian fold belt" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Folded-Light-Path Colloidal Quantum Dot Solar Cells  

E-Print Network [OSTI]

Folded-Light-Path Colloidal Quantum Dot Solar Cells Ghada I. Koleilat*, Illan J. Kramer*, Chris T, Canada. Colloidal quantum dot photovoltaics combine low-cost solution processing with quantum size-effect tuning to match absorption to the solar spectrum. Rapid advances have led to certified solar power

422

Ultraviolet resonance Raman spectroscopy of the integral membrane protein OmpA : elucidating structure and tryptophan microenvironment of folded and unfolded states  

E-Print Network [OSTI]

Intermediates in Membrane Protein Folding,” Biochemistry (Intermediates in Membrane Protein Folding,” Biochemistry (Engelman. “ Membrane-Protein Folding and Oligomerization -

Neary, Tiffany Jonean

2008-01-01T23:59:59.000Z

423

An evaluation of a weight-lifting belt and back injury prevention training class for fleet service clerks  

E-Print Network [OSTI]

. 3142 NS 0. 0323 0. 8390 NS 0. 1181 NS 0. 1606 NS 0. 4043 NS 0. 0703 NS ' Significant at pc0. 05. NS Non-Significant at pe0. 05 8: Belt Group 8&T: Belt & Training Group L: Line(inside/Outside Aircraft) BR: Bagroom C: Cabin Service M...AN EVALUATION OF A WEIGHT-LIFTING BELT AND BACK INJURY PREVENTION TRAINING CLASS FOR FLEET SERVICE CLERKS A Thesis by CHERYL RENEE REDDELL Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment...

Reddell, Cheryl Renee?

2012-06-07T23:59:59.000Z

424

International Scientific Conference Computer Science'2008 Near-Native Protein Folding  

E-Print Network [OSTI]

International Scientific Conference Computer Science'2008 61 Near-Native Protein Folding Stefka: The protein folding problem is a fundamental problem in computational molecular biology. The high resolution 3. After that the folding problem is de- fined like optimization problem. Keywords: Protein folding

Fidanova, Stefka

425

Estimates of the Loss of Main-Chain Conformational Entropy of Different Residues on Protein Folding  

E-Print Network [OSTI]

Estimates of the Loss of Main-Chain Conformational Entropy of Different Residues on Protein Folding energy of protein folding is not well understood. We have developed empirical scales for the loss; protein folding; pro- tein engineering INTRODUCTION When a protein folds into a compact globule, the resi

Pal, Debnath

426

Genetic Algorithm for Predicting Protein Folding in the 2D HP Model  

E-Print Network [OSTI]

Genetic Algorithm for Predicting Protein Folding in the 2D HP Model A Parameter Tuning Case Study of a protein, predicting its tertiary structure is known as the protein folding problem. This problem has been. The protein folding problem in the HP model is to find a conformation (a folded sequence) with the lowest

Emmerich, Michael

427

A New Algorithm for Protein Folding in the HP Model Alantha Newman *  

E-Print Network [OSTI]

876 A New Algorithm for Protein Folding in the HP Model Alantha Newman * Abstract We consider the problem of protein folding in the HP model ozt the two-dimensional square lattice. This problem.e.pairsof H's that are adjacent in the folding but not in the string) are present. The protein folding problem

Istrail, Sorin

428

Directed evolution methods for improving polypeptide folding and solubility and superfolder fluorescent proteins generated thereby  

DOE Patents [OSTI]

The current invention provides methods of improving folding of polypeptides using a poorly folding domain as a component of a fusion protein comprising the poorly folding domain and a polypeptide of interest to be improved. The invention also provides novel green fluorescent proteins (GFPs) and red fluorescent proteins that have enhanced folding properties.

Waldo, Geoffrey S. (Santa Fe, NM)

2007-09-18T23:59:59.000Z

429

Internal friction in the ultrafast folding of the tryptophan cage q Linlin Qiu 1  

E-Print Network [OSTI]

Internal friction in the ultrafast folding of the tryptophan cage q Linlin Qiu 1 , Stephen J. Hagen is a diffusional process, and the speed of folding is controlled by the frictional forces that act important source of friction in folding reactions. By contrast, our studies of the folding dynamics

Hagen, Stephen J.

430

Identifying the importance of amino acids for protein folding from crystal structures  

E-Print Network [OSTI]

Identifying the importance of amino acids for protein folding from crystal structures Nikolay V and characterizing protein folding kinetics from crystal structures using computational techniques. We also describe as the protein folding prob- lem [1­25], is of great importance because understanding protein folding mechanisms

Stanley, H. Eugene

431

The energy landscape for protein folding and possible connections to function  

E-Print Network [OSTI]

The energy landscape for protein folding and possible connections to function Margaret S. Cheunga to study protein folding. As good agreement between computational/theoretical studies and experimental-state proteins and larger proteins with more complex folding kinetics. How proteins fold from one

Onuchic, José

432

A new protein folding screen: Application to the ligand binding domains of a glutamate and kainate  

E-Print Network [OSTI]

A new protein folding screen: Application to the ligand binding domains of a glutamate and kainate of determining and evaluating protein folding conditions, we have designed a new fractional factorial protein folding screen. The screen includes 12 factors shown by previous experiments to enhance protein folding

Lebendiker, Mario

433

J. Mol. Biol. (1996) 264, 11641179 How to Derive a Protein Folding Potential? A New  

E-Print Network [OSTI]

J. Mol. Biol. (1996) 264, 1164­1179 How to Derive a Protein Folding Potential? A New Approach of deriving a pairwise potentialHarvard University Department of Chemistry for protein folding. The potential of accuracy. 7 1996 Academic Press Limited *Corresponding author Keywords: protein folding; protein folding

Mirny, Leonid

434

Constrained Proper Sampling of Conformations of Transition State Ensemble during Protein Folding  

E-Print Network [OSTI]

Constrained Proper Sampling of Conformations of Transition State Ensemble during Protein Folding) is important for studying protein folding. A promising approach pioneered by Vendruscolo et al40 to study TSE to understand how proteins fold to its native state8,29,37 . Protein folding is a complex process that involves

Dai, Yang

435

BiP Clustering Facilitates Protein Folding in the Endoplasmic Reticulum  

E-Print Network [OSTI]

BiP Clustering Facilitates Protein Folding in the Endoplasmic Reticulum Marc Griesemer1. *, Carissa (ER): translocation, protein folding, and ER-associated degradation. To facilitate protein folding may enhance protein folding and maturation. Scenarios were simulated to gauge the effectiveness

Petzold, Linda R.

436

Pairwise contact potentials are unsuitable for protein folding Michele Vendruscolo and Eytan Domany  

E-Print Network [OSTI]

Pairwise contact potentials are unsuitable for protein folding Michele Vendruscolo and Eytan Domany: protein folding; protein folding potential; contact map; neural networks; per­ ceptron. I. INTRODUCTION of protein folding [1] is to predict proteins' native structures from their amino acid sequences; solution

Domany, Eytan

437

Identification of characteristic protein folding channels in a coarse-grained hydrophobic-polar peptide model  

E-Print Network [OSTI]

Identification of characteristic protein folding channels in a coarse-grained hydrophobic of protein folding is one of the major challenges of modern interdisciplinary science. Proteins are linear simulations of protein folding are difficult, mainly for two reasons. Firstly, the folding process is so slow

Bachmann, Michael

438

proteinsSTRUCTURE O FUNCTION O BIOINFORMATICS Studying submicrosecond protein folding  

E-Print Network [OSTI]

proteinsSTRUCTURE O FUNCTION O BIOINFORMATICS Studying submicrosecond protein folding kinetics INTRODUCTION To understand the intrinsic principles of protein folding, the events in the folding process have to be systematically explored from small to large time scales. Tradi- tional methods for triggering protein folding

439

In and Out of the ER: Protein Folding, Quality Control, Degradation, and Related Human Diseases  

E-Print Network [OSTI]

In and Out of the ER: Protein Folding, Quality Control, Degradation, and Related Human Diseases 1377 C. Protein folding 1378 II. Protein Translocation, Folding, and Quality Control in the Endoplasmic Reticulum 1379 A. Protein targeting to the ER 1379 B. Chaperone-assisted protein folding in the ER 1379 C

Hebert, Daniel N.

440

John von Neumann Institute for Computing Different Types of Protein Folding Identified with  

E-Print Network [OSTI]

John von Neumann Institute for Computing Different Types of Protein Folding Identified://www.fz-juelich.de/nic-series/volume40 #12;Different Types of Protein Folding Identified with a Coarse-Grained Heteropolymer Model Stefan The identification of folding channels is one of the key tasks of protein folding studies. While secondary structures

Janke, Wolfhard

Note: This page contains sample records for the topic "appalachian fold belt" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Predicting Experimental Quantities in Protein Folding Kinetics using Stochastic Roadmap Simulation  

E-Print Network [OSTI]

Predicting Experimental Quantities in Protein Folding Kinetics using Stochastic Roadmap Simulation the transition state ensemble (TSE) and predict the rates and -values for protein folding. The new method as a gen- eral tool for studying protein folding kinetics. 1 Introduction Protein folding is a crucial

Pratt, Vaughan

442

A New Method for Modeling and Solving the Protein Fold Recognition Problem  

E-Print Network [OSTI]

Idstract A New Method for Modeling and Solving the Protein Fold Recognition Problem (Extended}@ornl.gov Computational recognition of native-like folds from a protein fold database is considered to be a promising recog- nition through optimally aligning (threading) an amino acid sequence and a protein fold (template

Istrail, Sorin

443

A Branch and Bound Algorithm for the Protein Folding Problem in the HP Lattice Model  

E-Print Network [OSTI]

Article A Branch and Bound Algorithm for the Protein Folding Problem in the HP Lattice Model Mao tool for the protein folding problem. Key words: protein folding, HP model, branch and bound, lattice Introduction The protein folding problem, or the protein struc- ture prediction problem, is one of the most

Istrail, Sorin

444

Autotransporters: The Cellular Environment Reshapes a Folding Mechanism to Promote Protein Transport  

E-Print Network [OSTI]

the cellular environment affects protein folding mechanisms. Here, we focus on one unique aspect affect protein folding kinetics and the conformations of folding intermediates? We focus on recent have been made to understand the mechanisms by which proteins fold to their native conformations.3

Clark, Patricia L.

445

Low-Dimensional Free Energy Landscapes of Protein Folding Reactions by Nonlinear Dimensionality Reduction  

E-Print Network [OSTI]

Low-Dimensional Free Energy Landscapes of Protein Folding Reactions by Nonlinear Dimensionality(26):9885-9890, 2006 #12;Abstract The definition of reaction coordinates for the characterization of a protein folding along the main folding route. These results clearly show that a complex process such as protein folding

Kavraki, Lydia E.

446

Restoring Sustainable Forests on Appalachian Mined Lands for Wood Product, Renewable Energy, Carbon Sequestration, and Other Ecosystem Services  

SciTech Connect (OSTI)

Concentrations of CO{sub 2} in the Earth’s atmosphere have increased dramatically in the past 100 years due to deforestation, land use change, and fossil fuel combustion. These humancaused, higher levels of CO{sub 2} may enhance the atmospheric greenhouse effect and may contribute to climate change. Many reclaimed coal-surface mine areas in the eastern U.S. are not in productive use. Reforestation of these lands could provide societal benefits, including sequestration of atmospheric carbon. The goal of this project was to determine the biological and economic feasibility of restoring high-quality forests on the tens of thousands of hectares of mined land and to measure carbon sequestration and wood production benefits that would be achieved from large-scale application of forest restoration procedures. We developed a mine soil quality model that can be used to estimate the suitability of selected mined sites for carbon sequestration projects. Across the mine soil quality gradient, we tested survival and growth performance of three species assemblages under three levels of silvicultural. Hardwood species survived well in WV and VA, and survived better than the other species used in OH, while white pine had the poorest survival of all species at all sites. Survival was particularly good for the site-specific hardwoods planted at each site. Weed control plus tillage may be the optimum treatment for hardwoods and white pine, as any increased growth resulting from fertilization may not offset the decreased survival that accompanied fertilization. Grassland to forest conversion costs may be a major contributor to the lack of reforestation of previously reclaimed mine lands in the Appalachian coal-mining region. Otherwise profitable forestry opportunities may be precluded by these conversion costs, which for many combinations of factors (site class, forest type, timber prices, regeneration intensity, and interest rate) result in negative land expectation values. Improved technology and/or knowledge of reforestation practices in these situations may provide opportunities to reduce the costs of converting many of these sites as research continues into these practices. It also appears that in many cases substantial payments, non-revenue values, or carbon values are required to reach “profitability” under the present circumstances. It is unclear when, or in what form, markets will develop to support any of these add-on values to supplement commercial forestry revenues. However, as these markets do develop, they will only enhance the viability of forestry on reclaimed mined lands, although as we demonstrate in our analysis of carbon payments, the form of the revenue source may itself influence management, potentially mitigating some of the benefits of reforestation. For a representative mined-land resource base, reforestation of mined lands with mixed pine-hardwood species would result in an average estimated C accumulation in forms that can be harvested for use as wood products or are likely to remain in the soil C pool at ~250 Mg C ha{sup -1} over a 60 year period following reforestation. The “additionality” of this potential C sequestration was estimated considering data in scientific literature that defines C accumulation in mined-land grasslands over the long term. Given assumptions detailed in the text, these lands have the potential to sequester ~180 Mg C ha{sup -1}, a total of 53.5 x 10{sup 6} Mg C, over 60 years, an average of ~900,000 Mg C / yr, an amount equivalent to about 0.04% of projected US C emissions at the midpoint of a 60-year period (circa 2040) following assumed reforestation. Although potential sequestration quantities are not great relative to potential national needs should an energy-related C emissions offset requirement be developed at some future date, these lands are available and unused for other economically valued purposes and many possess soil and site properties that are well-suited to reforestation. Should such reforestation occur, it would also produce ancillary benefits by providing env

James A. Burger

2006-09-30T23:59:59.000Z

447

* Corresponding author. : Primary student contributor. Folding-aware and Structure-conscious 3D Substructures in Folding Data: Identification and Applications  

E-Print Network [OSTI]

employed by biologists to study the protein folding problem. Such simulations have resulted in a large number of protein folding trajectories, each of which consists of a sequence of three, and cross-trajectory comparison. Key Words: protein folding trajectories, 3D substructure identification

Yang, Hui

448

The role of sidechain packing and native contact interactions in folding: Discontinuous molecular dynamics folding simulations of an all-atom  

E-Print Network [OSTI]

structures of proteins, has been extensively investigated to examine its role in protein folding. However the important role of sidechain packing in determining the specific pathway of protein folding. Additional 96 of Physics. DOI: 10.1063/1.1514574 I. INTRODUCTION Theoretical/computational studies of protein folding

Zhou, Yaoqi

449

Different Kinds of Protein Folding Identified with a Coarse-Grained Heteropolymer Model  

E-Print Network [OSTI]

Applying multicanonical simulations we investigated folding properties of off-lattice heteropolymers employing a mesoscopic hydrophobic-polar model. We study for various sequences folding channels in the free-energy landscape by comparing the equilibrium conformations with the folded state in terms of an angular overlap parameter. Although all investigated heteropolymer sequences contain the same content of hydrophobic and polar monomers, our analysis of the folding channels reveals a variety of characteristic folding behaviors known from realistic peptides.

Stefan Schnabel; Michael Bachmann; Wolfhard Janke

2009-02-16T23:59:59.000Z

450

Warm Conveyor Belts in the ERA-Interim Dataset (1979–2010). Part II: Moisture Origin and Relevance for Precipitation  

Science Journals Connector (OSTI)

The role of moisture for extratropical atmospheric dynamics is particularly pronounced within warm conveyor belts (WCBs), which are characterized by intense latent heat release and precipitation formation. Based on the WCB climatology for the ...

Stephan Pfahl; Erica Madonna; Maxi Boettcher; Hanna Joos; Heini Wernli

2014-01-01T23:59:59.000Z

451

Dropouts of the outer electron radiation belt in response to solar wind stream interfaces: global positioning system observations  

Science Journals Connector (OSTI)

...radiation belt in response to solar wind stream interfaces: global...Calgary, Calgary, Alberta, Canada We present a statistical study...examined statistically for 67 solar wind stream interfaces (SIs...global positioning system|solar wind| 1. Introduction (a...

2010-01-01T23:59:59.000Z

452

A study on the effects of seat belt posters on drivers  

Science Journals Connector (OSTI)

The primary aim of this study was to identify the effects of several posters designed to encourage the use of seat belts on drivers. Discovering the seat belt use habits of drivers and their reasons for failing to use them constitute the secondary aims of the study. In order to fulfill these aims, four different posters appealing to drivers’ safety and normative motivations were designed. The drivers were then asked to choose the poster that impressed them most. Half of the drivers chose the first poster, which drew a parallelism between the casualites of terrorism, earthquake and traffic, as most impressive. The second most impressive poster was the fourth one, which emphasized the link between traffic rules and morality. Female drivers found this poster with a moral message more impressive than males. Another finding of the study was that primary school and university graduates were more impressed by the posters appealing to normative motivation.

Oktay Akba?; Resul Güven; Gonca Cebeci; Seydi Battal Bertlek; Gül?ah Aldemir; Elif Bal

2010-01-01T23:59:59.000Z

453

Main-belt comets as tracers of ice in the inner Solar system  

E-Print Network [OSTI]

As a recently recognized class of objects exhibiting apparently cometary (sublimation-driven) activity yet orbiting completely within the main asteroid belt, main-belt comets (MBCs) have revealed the existence of present-day ice in small bodies in the inner solar system and offer an opportunity to better understand the thermal and compositional history of our solar system, and by extension, those of other planetary systems as well. Achieving these overall goals, however, will require meeting various intermediate research objectives, including discovering many more MBCs than the currently known seven objects in order to ascertain the population's true abundance and distribution, confirming that water ice sublimation is in fact the driver of activity in these objects, and improving our understanding of the physical, dynamical, and thermal evolutionary processes that have acted on this population over the age of the solar system.

Hsieh, Henry H

2014-01-01T23:59:59.000Z

454

Online monitoring of a belt grinding process by using a light scattering method  

SciTech Connect (OSTI)

Industrially ground surfaces often have a characteristic surface topography known as chatter marks. The surface finishing is mainly monitored by optical measurement techniques. In this work, the monitoring of an industrial belt grinding process with a light scattering sensor is presented. Although this technique is primarily applied for parametric surface roughness analysis, here it is shown that it enables also the measurement of the surface topography, i.e., the chatter marks occurring during the belt grinding process. In particular, it is proven that the light scattering method is appropriate to measure online the topography of chatter marks. Furthermore, the frequency analysis of the data reveals that the wavelength of chatter marks strongly depends on process parameters, such as the grinding speed.

Boehm, Johannes; Vernes, Andras; Vorlaufer, Georg; Vellekoop, Michael

2010-10-20T23:59:59.000Z

455

Viscosity Dependence of the Folding Rates of Proteins  

Science Journals Connector (OSTI)

The viscosity (?) dependence of the folding rates for four sequences (the native state of three sequences is a ? sheet, while the fourth forms an ? helix) is calculated for off-lattice models of proteins. Assuming that the dynamics is given by the Langevin equation, we show that the folding rates increase linearly at low viscosities ?, decrease as 1/? at large ?, and have a maximum at intermediate values. The Kramers' theory of barrier crossing provides a quantitative fit of the numerical results. By mapping the simulation results to real proteins we estimate that for optimized sequences the time scale for forming a four turn ?-helix topology is about 500 ns, whereas for ? sheet it is about 10 ?s.

D. K. Klimov and D. Thirumalai

1997-07-14T23:59:59.000Z

456

Strong Nernst-Ettingshausen effect in folded graphene  

E-Print Network [OSTI]

We study electronic transport in graphene under the influence of a transversal magnetic field $\\f{B}(\\f{r})=B(x)\\f{e}_z$ with the asymptotics $B(x\\to\\pm\\infty)=\\pm B_0$, which could be realized via a folded graphene sheet in a constant magnetic field, for example. By solving the effective Dirac equation, we find robust modes with a finite energy gap which propagate along the fold -- where particles and holes move in opposite directions. Exciting these particle-hole pairs with incident photons would then generate a nearly perfect charge separation and thus a strong magneto-thermoelectric (Nernst-Ettingshausen) or magneto-photoelectric effect -- even at room temperature.

Friedemann Queisser; Ralf Schützhold

2013-01-17T23:59:59.000Z

457

A coarse-grained, ``realistic'' model for Protein Folding  

E-Print Network [OSTI]

A phenomenological model hamiltonian to describe the folding of a protein with any given sequence is proposed. The protein is thought of as a collection of pieces of helices; as a consequence its configuration space increases with the number of secondary structure elements rather than with the number of residues. The hamiltonian presents both local (i.e. single helix, accounting for the stiffness of the chain) and non local (interactions between hydrophobically-charged helices) terms, and is expected to provide a first tool for studying the folding of real proteins. The partition function for a simplified, but by no means trivial, version of the model is calculated almost completely in an analytical way. The latter simplified model is also applied to the study of a synthetic protein, and some preliminary results are shown.

Pierpaolo Bruscolini

1997-07-24T23:59:59.000Z

458

Invariant patterns in crystal lattices: Implications for protein folding algorithms  

SciTech Connect (OSTI)

Crystal lattices are infinite periodic graphs that occur naturally in a variety of geometries and which are of fundamental importance in polymer science. Discrete models of protein folding use crystal lattices to define the space of protein conformations. Because various crystal lattices provide discretizations of the same physical phenomenon, it is reasonable to expect that there will exist invariants across lattices related to fundamental properties of the protein folding process. This paper considers whether performance-guaranteed approximability is such an invariant for HP lattice models. The authors define a master approximation algorithm that has provable performance guarantees provided that a specific sublattice exists within a given lattice. They describe a broad class of crystal lattices that are approximable, which further suggests that approximability is a general property of HP lattice models.

HART,WILLIAM E.; ISTRAIL,SORIN

2000-06-01T23:59:59.000Z

459

When pigs fly: a study of computer generated paper folding  

E-Print Network [OSTI]

&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE Approved by: Chair of Committee, Carol LaFayette Committee Members, Frederic I. Parke Michael Greenwald Head of Department, Tim McLaughlin December 2008... Major Subject: Visualization Sciences iii ABSTRACT When Pigs Fly: A Study of Computer Generated Paper Folding. (December 2008) Elizabeth Jeanette Nitsch, B.E.D., Texas A&M University Chair of Advisory Committee: Prof. Carol LaFayette...

Nitsch, Elizabeth Jeanette

2009-05-15T23:59:59.000Z

460

Invariant patterns in crystal lattices: Implications for protein folding algorithms  

SciTech Connect (OSTI)

Crystal lattices are infinite periodic graphs that occur naturally in a variety of geometries and which are of fundamental importance in polymer science. Discrete models of protein folding use crystal lattices to define the space of protein conformations. Because various crystal lattices provide discretizations of the same physical phenomenon, it is reasonable to expect that there will exist ``invariants`` across lattices that define fundamental properties of protein folding process; an invariant defines a property that transcends particular lattice formulations. This paper identifies two classes of invariants, defined in terms of sublattices that are related to the design of algorithms for the structure prediction problem. The first class of invariants is, used to define a master approximation algorithm for which provable performance guarantees exist. This algorithm can be applied to generalizations of the hydrophobic-hydrophilic model that have lattices other than the cubic lattice, including most of the crystal lattices commonly used in protein folding lattice models. The second class of invariants applies to a related lattice model. Using these invariants, we show that for this model the structure prediction problem is intractable across a variety of three-dimensional lattices. It`` turns out that these two classes of invariants are respectively sublattices of the two- and three-dimensional square lattice. As the square lattices are the standard lattices used in empirical protein folding` studies, our results provide a rigorous confirmation of the ability of these lattices to provide insight into biological phenomenon. Our results are the first in the literature that identify algorithmic paradigms for the protein structure prediction problem which transcend particular lattice formulations.

Hart, W.E.; Istrail, S.

1995-12-11T23:59:59.000Z

Note: This page contains sample records for the topic "appalachian fold belt" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Elastic energy of proteins and the stages of protein folding  

E-Print Network [OSTI]

We propose a universal elastic energy for proteins, which depends only on the radius of gyration $R_{g}$ and the residue number $N$. It is constructed using physical arguments based on the hydrophobic effect and hydrogen bonding. Adjustable parameters are fitted to data from the computer simulation of the folding of a set of proteins using the CSAW (conditioned self-avoiding walk) model. The elastic energy gives rise to scaling relations of the form $R_{g}\\sim N^{\

Lei, Jinzhi

2010-01-01T23:59:59.000Z

462

Combined approach to the inverse protein folding problem. Final report  

SciTech Connect (OSTI)

The main scientific contribution of the project ''Combined approach to the inverse protein folding problem'' submitted in 1996 and funded by the Department of Energy in 1997 is the formulation and development of the idea of the multilink recognition method for identification of functional and structural homologues of newly discovered genes. This idea became very popular after they first announced it and used it in prediction of the threading targets for the CASP2 competition (Critical Assessment of Structure Prediction).

Ruben A. Abagyan

2000-06-01T23:59:59.000Z

463

Review Protein folding: Then and now www.elsevier.com/locate/yabbi  

E-Print Network [OSTI]

Over the past three decades the protein folding field has undergone monumental changes. Originally a purely academic question, how a protein folds has now become vital in understanding diseases and our abilities to rationally manipulate cellular life by engineering protein folding pathways. We review and contrast past and recent developments in the protein folding field. Specifically, we discuss the progress in our understanding of protein folding thermodynamics and kinetics, the properties of evasive intermediates, and unfolded states. We also discuss how some abnormalities in protein folding lead to protein aggregation and human diseases.

Yiwen Chen; Feng Ding; Huifen Nie; Adrian W. Serohijos; Shantanu Sharma; Kyle C. Wilcox; Shuangye Yin; Nikolay V. Dokholyan

2007-01-01T23:59:59.000Z

464

Folded reflective tandem polymer solar cell doubles efficiency  

Science Journals Connector (OSTI)

Conjugated polymers are promising materials for the production of inexpensive and flexible photovoltaic cells. Organic materials display tunable optical absorption within a large spectral range. This enables the construction of organic tandem photovoltaic cells. The authors here demonstrate a reflective tandem cell where single cells are reflecting the nonabsorbed light upon another adjacent cell. By folding two planar but spectrally different cells toward each other spectral broadening and light trapping are combined to give an enhancement of power conversion efficiency of a factor of 1.8 ± 0.3 .

Kristofer Tvingstedt; Viktor Andersson; Fengling Zhang; Olle Inganäs

2007-01-01T23:59:59.000Z

465

Directed transport as a mechanism for protein folding in vivo  

E-Print Network [OSTI]

We propose a model for protein folding in vivo based on a Brownian-ratchet mechanism in the multidimensional energy landscape space. The device is able to produce directed transport taking advantage of the assumed intrinsic asymmetric properties of the proteins and employing the consumption of energy provided by an external source. Through such a directed transport phenomenon, the polypeptide finds the native state starting from any initial state in the energy landscape with great efficacy and robustness, even in the presence of different type of obstacles. This model solves Levinthal's paradox without requiring biased transition probabilities but at the expense of opening the system to an external field.

Ernesto Gonzalez-Candela; Victor Romero-Rochin

2009-09-23T23:59:59.000Z

466

Microsecond Microfluidic Mixing for Investigation of Protein Folding Kinetics  

SciTech Connect (OSTI)

We have developed and characterized a mixer to study the reaction kinetics of protein folding on a microsecond timescale. The mixer uses hydrodynamic focusing of pressure-driven flow in a microfluidic channel to reduce diffusion times as first demonstrated by Knight et al.[1]. Features of the mixer include 1 {micro}s mixing times, sample consumptions of order 1 nl/s, loading sample volumes on the order of microliters, and the ability to manufacture in fused silica for compatibility with most spectroscopic methods.

Hertzog, D E; Santiago, J G; Bakajin, O

2005-02-10T23:59:59.000Z

467

Microsecond Microfluidic Mixing for Investigation of Protein Folding Kinetics  

SciTech Connect (OSTI)

We have developed and characterized a mixer to study the reaction kinetics of protein folding on a microsecond timescale. The mixer uses hydrodynamic focusing of pressure-driven flow in a microfluidic channel to reduce diffusion times as first demonstrated by Knight et al.[1]. Features of the mixer include 1 {micro}s mixing times, sample consumptions of order 1 nl/s, loading sample volumes on the order of microliters, and the ability to manufacture in fused silica for compatibility with most spectroscopic methods.

Hertzog, D E; Santiago, J G; Bakajin, O

2003-06-25T23:59:59.000Z

468

Conformation changes and protein folding induced by \\phi^4 interaction  

E-Print Network [OSTI]

A model to describe the mechanism of conformational dynamics in protein based on matter interactions using lagrangian approach and imposing certain symmetry breaking is proposed. Both conformation changes of proteins and the injected non-linear sources are represented by the bosonic lagrangian with an additional \\phi^4 interaction for the sources. In the model the spring tension of protein representing the internal hydrogen bonds is realized as the interactions between individual amino acids and nonlinear sources. The folding pathway is determined by the strength of nonlinear sources that propagate through the protein backbone. It is also shown that the model reproduces the results in some previous works.

Januar, M; Handoko, L T

2011-01-01T23:59:59.000Z

469

Renaissance of paper models and folded plate structures in glass  

Science Journals Connector (OSTI)

This paper presents the development of glass folded plate structures. Glass will not only be used as a transparent covering but as a load-bearing element for the whole structure. A complete outline ranging from the architectural approach including simple paper models to structural analysis will be presented. The structural concept and its functional characteristics will be confirmed by finite element analysis. Moreover, this paper will also put into focus the geometrical diversity and individuality and will present mathematical algorithms as definitions of the geometrical freeform.

Stefan Trometer; Mathias Krupna

2010-01-01T23:59:59.000Z

470

A Route to Scale up DNA Origami Using DNA Tiles as Folding Staples  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

A Route to Scale up DNA Origami Using DNA Tiles as Folding Staples Authors: Zhao, Z., Yan, H., and Liu, Y. Title: A Route to Scale up DNA Origami Using DNA Tiles as Folding Staples...

471

Protein folding and macromolecular dynamics : fundamental limits of length and time scales.  

E-Print Network [OSTI]

??In this thesis, physics-based models of protein folding at the secondary and tertiary level are developed to resolve long-standing issues of protein folding kinetics. As… (more)

Lin, Milo M.

2012-01-01T23:59:59.000Z

472

SciTech Connect: Protein-folding via divide-and-conquer optimization  

Office of Scientific and Technical Information (OSTI)

Protein-folding via divide-and-conquer optimization Citation Details In-Document Search Title: Protein-folding via divide-and-conquer optimization You are accessing a document...

473

Protein folding and phylogenetic tree reconstruction using stochastic approximation Monte Carlo  

E-Print Network [OSTI]

folding problems. The numerical results indicate that it outperforms simulated annealing and conventional Monte Carlo algorithms as a stochastic optimization algorithm. We also propose one method for the use of secondary structures in protein folding...

Cheon, Sooyoung

2007-09-17T23:59:59.000Z

474

Self-organization and mismatch tolerance in protein folding: General theory and an application  

E-Print Network [OSTI]

Self-organization and mismatch tolerance in protein folding: General theory and an application approaches to the so-called protein folding problem, mainly because the microscopic models have no explicit

Berry, R. Stephen

475

SciTech Connect: Protein-Folding Landscapes in Multi-Chain Systems  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Protein-Folding Landscapes in Multi-Chain Systems Citation Details In-Document Search Title: Protein-Folding Landscapes in Multi-Chain Systems Computational studies of proteins...

476

Efficient Traversal of Beta-Sheet Protein Folding Pathways Using Ensemble Models  

E-Print Network [OSTI]

Efficient Traversal of Beta-Sheet Protein Folding Pathways Using Ensemble Models SOLOMON SHENKER,1 introduce a complete methodology to

Gifford, David K.

477

The Trp Cage: Folding Kinetics and Unfolded State Topology via Molecular Dynamics Simulations  

E-Print Network [OSTI]

, ) 91 ps-1). The Folding@Home distributed computing project was used to generate an aggregate simulation

Snow, Christopher

478

Controlling protein molecular dynamics: How to accelerate folding while preserving the native state  

E-Print Network [OSTI]

pioneered, in particular, in the Folding@Home project and taken to the extent where hundred of thousands

Nerukh, Dmitry

479

Identification of Characteristic Protein Folding Channels in a Coarse-Grained Hydrophobic-Polar Peptide Model  

E-Print Network [OSTI]

Folding channels and free-energy landscapes of hydrophobic-polar heteropolymers are discussed on the basis of a minimalistic off-lattice coarse-grained model. We investigate how rearrangements of hydrophobic and polar monomers in a heteropolymer sequence lead to completely different folding behaviors. Studying three exemplified sequences with the same content of hydrophobic and polar residues, we can reproduce within this simple model two-state folding, folding through intermediates, as well as metastability.

Stefan Schnabel; Michael Bachmann; Wolfhard Janke

2007-10-25T23:59:59.000Z

480

Sticker controller and sticker programming for smart sheets (self-folding sheets)  

E-Print Network [OSTI]

This thesis describes a self-folding sheet that is capable of origami-style autonomous folding. We describe the hardware device we designed and fabricated. This device, called a self-folding sheet, is a sheet with a box-pleat ...

An, Byoungkwon

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "appalachian fold belt" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

How the diffusivity profile reduces the arbitrariness of protein folding free energies  

E-Print Network [OSTI]

How the diffusivity profile reduces the arbitrariness of protein folding free energies M 2010 The concept of a protein diffusing in its free-energy folding landscape has been fruitful for both as it stochastically folds and unfolds. The free-energy profiles for different RCs exhibit significant variations, some

Thirumalai, Devarajan

482

PROTEIN FOLD RECOGNITION USING RESIDUE-BASED ALIGNMENTS OF SEQUENCE AND SECONDARY STRUCTURE  

E-Print Network [OSTI]

PROTEIN FOLD RECOGNITION USING RESIDUE-BASED ALIGNMENTS OF SEQUENCE AND SECONDARY STRUCTURE Zafer methods [3,4]. Index Terms- protein fold recognition, secondary structure alignment, amino acid alignment &sabanciuniv.edu culated for each sequence-structure alignment. Protein fold recog- nition problem can

Erdogan, Hakan

483

A New Algorithm for Protein Folding in the HP Model Alantha Newman  

E-Print Network [OSTI]

A New Algorithm for Protein Folding in the HP Model Alantha Newman #3; Abstract We consider the problem of protein folding in the HP model on the two-dimensional square lattice. This problem but not in the string) are present. The protein folding problem in the hydrophobic-hydrophilic (HP) model on the 2D

Newman, Alantha

484

Protein Folding, Spin Glass and Computational Complexity 1 Aviezri S. Fraenkel  

E-Print Network [OSTI]

Protein Folding, Spin Glass and Computational Complexity 1 Aviezri S. Fraenkel Abstract of protein folding to solve computationally intractable problems. One way of investigating this idea is to encode known NP­complete problems in terms of protein folding. The main content of this paper is to do

Fraenkel, Aviezri

485

An Improved Ant Colony Optimisation Algorithm for the 2D HP Protein Folding Problem  

E-Print Network [OSTI]

An Improved Ant Colony Optimisation Algorithm for the 2D HP Protein Folding Problem Alena hydrophobic-polar (2D HP) protein folding problem. We present an improved version of our recently proposed Ant search. Overall, the results presented here establish our new ACO algorithm for 2D HP protein folding

Hoos, Holger H.

486

Cotranslational protein folding with L-systems Gemma B. Danks1,2  

E-Print Network [OSTI]

Cotranslational protein folding with L-systems Gemma B. Danks1,2 , Susan Stepney2 , and Leo S. D-systems, parallel rewriting rules, to modelling protein folding using two complementary approaches: a physics an adaptive stochas- tic open L-systems model of protein folding. L-systems were originally developed to model

Stepney, Susan

487

Sequence-Based Prediction of Protein Folding Rates Using Contacts, Secondary Structures and Support Vector Machines  

E-Print Network [OSTI]

Sequence-Based Prediction of Protein Folding Rates Using Contacts, Secondary Structures and Support, Columbia, Missouri * Corresponding author: chengji@missouri.edu Abstract Predicting protein folding rate is useful for understanding protein folding process and guiding protein design. Here we developed a method

Cheng, Jianlin Jack

488

An Ant Colony Optimization Algorithm for the 2D HP Protein Folding Problem  

E-Print Network [OSTI]

An Ant Colony Optimization Algorithm for the 2D HP Protein Folding Problem Alena Shmygelska, Rosal, the two dimensional hydrophobic-polar (2D HP) protein folding problem. We introduce an ant colony algorithm closely approaches that of specialised, state-of-the methods for 2D HP protein folding. 1

Hoos, Holger H.

489

Patterns of Protein-Fold Usage in Eight Microbial Genomes: A Comprehensive Structural Census  

E-Print Network [OSTI]

Patterns of Protein-Fold Usage in Eight Microbial Genomes: A Comprehensive Structural Census Mark in terms of patterns of fold usage--whether a given fold occurs in a particular organism. Of the 340 be analyzed through trans- membrane-helix (TM) prediction. All the genomes appear to have similar usage

Gerstein, Mark

490

ORIGINAL RESEARCH PAPER Canyon-infilling and gas hydrate occurrences in the frontal fold  

E-Print Network [OSTI]

ORIGINAL RESEARCH PAPER Canyon-infilling and gas hydrate occurrences in the frontal fold to infer the canyon-infilling, fold uplift, and gas hydrate occurrences beneath the frontal fold at the toe simu- lating reflector (BSR) on seismic sections indicates the base of gas hydrate stability zone

Lin, Andrew Tien-Shun

491

BarMap: RNA Folding on Dynamics Energy Landscapes Ivo L. Hofacker,a  

E-Print Network [OSTI]

of pulling polymers through a pore. Key words: RNA folding kinetics, barrier tree, dynamic energy landscapeBarMap: RNA Folding on Dynamics Energy Landscapes Ivo L. Hofacker,a , Christoph Flamma , Christian required to analyse the folding energy landscapes to a one-time preprocessing step. The basic idea

Flamm, Christoph

492

Using Motion Planning to Study Protein Folding Pathways Department of Computer Science  

E-Print Network [OSTI]

Using Motion Planning to Study Protein Folding Pathways #3; Guang Song Department of Computer a framework for studying protein folding path- ways and potential landscapes which is based on techniques and study with other methods. Our focus in this work is to study the protein folding mech- anism assuming we

LaValle, Steven M.

493

Part 1: Protein Dynamics Folded protein at physiologic or room temperature samples wide range of  

E-Print Network [OSTI]

protein molecule is likely to differ significantly from average structure - folded protein is an ensemble(unfolded state) 2 Aside 1: What disordered states are relevant to understand protein folding? compact denatured Protein Motions within Folded State Ensemble high energy costs of deformations of bond lengths, angles

Chan, Hue Sun

494

Topological Aspects of DNA Function and Protein Folding 533 Identifying knots in proteins  

E-Print Network [OSTI]

Topological Aspects of DNA Function and Protein Folding 533 Identifying knots in proteins Kenneth C proteins. How these knotted proteins fold and finding the evolutionary advantage provided by these knots are among some of the key questions currently being studied in the protein folding field. The detection

Bigelow, Stephen

495

Protein Folding in the Hydrophobic-Hydrophilic (HP) Model is NP-Complete  

E-Print Network [OSTI]

Protein Folding in the Hydrophobic-Hydrophilic (HP) Model is NP-Complete Bonnie Berger* Tom Leightont Abstract One of the simplest and most popular biophysical mod- els of protein folding is the hydrophobic-hydrophilic (HP) model. The HP model abstracts the hydrophobic in- teraction in protein folding

Istrail, Sorin

496

Single-molecule spectroscopy of protein folding in a chaperonin cage  

E-Print Network [OSTI]

Single-molecule spectroscopy of protein folding in a chaperonin cage Hagen Hofmanna , Frank for avoiding protein aggregation in vivo, but it is still unclear how they affect protein folding mechanisms In the recent past, a large number of components have been identified that control and modulate protein folding

Lipman, Everett A.

497

Hydrophobic Aided Replica Exchange: an Efficient Algorithm for Protein Folding in Explicit Solvent  

E-Print Network [OSTI]

Hydrophobic Aided Replica Exchange: an Efficient Algorithm for Protein Folding in Explicit Solvent protein folding in explicit solvent. This method is based on exaggerating the hydrophobic effect understanding of protein folding and misfolding is critical to many problems in computational biology.1 Many

Berne, Bruce J.

498

Lattice Protein Folding With Two and Four-Body Statistical Hin Hark Gan,1  

E-Print Network [OSTI]

Lattice Protein Folding With Two and Four-Body Statistical Potentials Hin Hark Gan,1 Alexander/sequence compatibility of proteins,5,6 homology modeling,7 and protein folding simulations.8 ­10 Currently, most structures. Multibody potentials may help improve our understanding of the cooperativity of protein folding

Schlick, Tamar

499

Techniques for modeling and analyzing RNA and protein folding energy landscapes  

E-Print Network [OSTI]

techniques can be used to study RNA and protein fold- ing kinetics such as population kinetics, folding rates, and the folding of particular subsequences. In particular, a map-based Master Equation (MME) method can be used to analyze the population kinetics...

Tang, Xinyu

2009-05-15T23:59:59.000Z

500

Reliable Protein Folding on Complex Energy Landscapes: The Free Energy Reaction Path  

E-Print Network [OSTI]

Reliable Protein Folding on Complex Energy Landscapes: The Free Energy Reaction Path Gregg Lois the dynamics of protein folding. The key insight is that the search for the native protein conformation. In the ``new view'' of protein folding (3,7), statistical fluctuations on an energy landscape give rise

O'Hern, Corey S.