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  1. 1/Documents/Word/WSH forms/LSUHSC Supervisor Instruction DT and Fitness for Duty RV 2 March 4, 2009 LSUHSC NEW ORLEANS CAMPUS -SUPERVISOR'S INSTRUCTIONS

    E-Print Network [OSTI]

    1/Documents/Word/WSH forms/LSUHSC Supervisor Instruction DT and Fitness for Duty ­ RV 2 March 4, 2009 LSUHSC NEW ORLEANS CAMPUS - SUPERVISOR'S INSTRUCTIONS DRUG TESTING & FITNESS FOR DUTY REFERRAL. The length of time for completing a Fitness for Duty Evaluation will vary. If there are no complicating

  2. Delays in Reducing Waterborne and Water-related Infectious Diseases in China under Climate Change

    SciTech Connect (OSTI)

    Hodges, Maggie; Belle, Jessica; Carlton, Elizabeth; Liang, Song; Li, Huazhong; Luo, Wei; Freeman, Matthew C.; Liu, Yang; Gao, Yang; Hess, Jeremy; Remais, Justin V.

    2014-12-01

    Despite China’s rapid progress improving water, sanitation and hygiene (WSH) infrastructure and access, in 2011, 471 million people lacked access to improved sanitation, and 401 million people lacked access to household piped water. Infectious diseases are sensitive to changes in climate, particularly temperature, and WSH conditions. To explore possible impacts of climate change on these diseases in China in 2020 and 2030, we coupled estimates of the temperature sensitivity of diarrheal disease and three vector-borne diseases, temperature projections from global climate models using four emissions pathways, WSH-infrastructure development scenarios and projected demographic changes. By 2030, the projected impacts would delay China’s historically rapid progress toward reducing the burden of WSH-attributable infectious disease by 8-85 months. This developmental delay provides a key summary measure of the impact of climate change in China, and in other societies undergoing rapid social, economic, and environmental change.

  3. Mar Biol (2008) 154:465474 DOI 10.1007/s00227-008-0941-z

    E-Print Network [OSTI]

    2008-01-01

    Mar Biol (2008) 154:465­474 DOI 10.1007/s00227-008-0941-z 123 RESEARCH ARTICLE Tropical Wshes diversity, even in the eastern basin, pointing to an ancient colonization event. This suggests that both may reXect the re-colonization of areas in the Atlantic by Wsh that survived the cold phases in rela

  4. Worker Safety and Health and Nuclear Safety Quarterly Performance Analysis (January - March 2008)

    SciTech Connect (OSTI)

    Kerr, C E

    2009-10-07

    The DOE Office of Enforcement expects LLNL to 'implement comprehensive management and independent assessments that are effective in identifying deficiencies and broader problems in safety and security programs, as well as opportunities for continuous improvement within the organization' and to 'regularly perform assessments to evaluate implementation of the contractor's processes for screening and internal reporting.' LLNL has a self-assessment program, described in ES&H Manual Document 4.1, that includes line, management and independent assessments. LLNL also has in place a process to identify and report deficiencies of nuclear, worker safety and health and security requirements. In addition, the DOE Office of Enforcement expects LLNL to evaluate 'issues management databases to identify adverse trends, dominant problem areas, and potential repetitive events or conditions' (page 14, DOE Enforcement Process Overview, December 2007). LLNL requires that all worker safety and health and nuclear safety noncompliances be tracked as 'deficiencies' in the LLNL Issues Tracking System (ITS). Data from the ITS are analyzed for worker safety and health (WSH) and nuclear safety noncompliances that may meet the threshold for reporting to the DOE Noncompliance Tracking System (NTS). This report meets the expectations defined by the DOE Office of Enforcement to review the assessments conducted by LLNL, analyze the issues and noncompliances found in these assessments, and evaluate the data in the ITS database to identify adverse trends, dominant problem areas, and potential repetitive events or conditions. The report attempts to answer three questions: (1) Is LLNL evaluating its programs and state of compliance? (2) What is LLNL finding? (3) Is LLNL appropriately managing what it finds? The analysis in this report focuses on data from the first quarter of 2008 (January through March). This quarter is analyzed within the context of information identified in previous quarters to include April 2007 through March 2008. The results from analyzing the deficiencies are presented in accordance with the two primary NTS reporting thresholds for WSH and nuclear safety noncompliances: (1) those related to certain events or conditions and (2) those that are management issues. In addition, WSH noncompliances were also analyzed to determine if any fell under the 'other significant condition' threshold. This report also identifies noncompliance topical areas that may have issues that do not meet the NTS reporting threshold but should remain under observation. These are placed on the 'watch list' for continued analysis.

  5. Alternative modulation of protein–protein interactions by small molecules

    E-Print Network [OSTI]

    Fischer, Gerhard; Rossmann, Maxim; Hyvönen, Marko

    2015-05-15

    F0 (RG7112)Recently, bromodomains (BD) have moved into the focus of cancer drug discovery programs due to the enticing ability to control the activity of multiple genes activity simultaneously. BDs are sensors of epigenetic modifica- tions... , sclerosis 1AJ, 1A9, 1A8, 1A7, 1A6, 1A5, 1A4, 1A3, 15E, 14Z, 14X, 13F, 0NS, WSH, EAM (i-BET762), 73B (I-BET726, GSK1324726A), 9S3, 1K0 (RVX208) r, egeneration 2LK, 2LO, 2LL n EN5, EN5, JJ1, 7AH, A6K, A6M, UEK, VIQ, QMI, 2CB, 2CD, PS8 r BEN, 9LI, BZI, 0QW, 0QX...

  6. Performance Analysis: ITS Data through September 30, 2009

    SciTech Connect (OSTI)

    Kerr, C E

    2009-12-07

    Data from ITS was analyzed to understand the issues at LLNL and to identify issues that may require additional management attention and these that meet the threshold for reporting to the DOE Noncompliance Tracking System (NTS). In this report we discuss assessments and issues entered in ITS and compare the number and type presently entered in ITS to previous time periods. Issues reported in ITS were evaluated and discussed. The analysis identified two noncompliances that meet the threshold for reporting to the DOE NTS. All of the data in ITS is analyzed; however, the primary focus of this report is to meet requirements for performance analysis of specific functional areas. The DOE Office of Enforcement expects LLNL to 'implement comprehensive management and independent assessments that are effective in identifying deficiencies and broader problems in safety and security programs, as well as opportunities for continuous improvement within the organization' and to 'regularly perform assessments to evaluate implementation of the contractor's's processes for screening and internal reporting.' LLNL has a self-assessment program, described in the document applicable during this time period, ES&H Manual Document 4.1, that includes line, management and independent assessments. LLNL also has in place a process to identify and report deficiencies of nuclear, worker safety and health and security requirements. In addition, the DOE Office of Enforcement expects that 'issues management databases are used to identify adverse trends, dominant problem areas, and potential repetitive events or conditions' (page 15, DOE Enforcement Process Overview, June 2009). LLNL requires that all worker safety and health and nuclear safety noncompliances be tracked as 'deficiencies' in the LLNL Issues Tracking System (ITS). Data from the ITS are analyzed for worker safety and health (WSH) and nuclear safety noncompliances that may meet the threshold for reporting to the DOE Noncompliance Tracking System (NTS). This report meets the expectations defined by the DOE Office of Enforcement to evaluate implementation of internal processes for screening and reporting, review the assessments conducted by LLNL, analyze the noncompliances found in these assessments, and evaluate the data in the ITS database to identify adverse trends, dominant problem areas, and potential repetitive events or conditions. The report attempts to answer three questions: (1) Is LLNL evaluating its programs and state of compliance; (2) What is LLNL finding; and (3) Is LLNL appropriately managing what it finds? The results from analyzing the deficiencies are presented in accordance with the two primary NTS reporting thresholds for WSH and nuclear safety noncompliances: (1) those related to certain events or conditions and (2) those that are management issues. In addition, WSH noncompliances were also analyzed to determine if any fell under the 'other significant condition' threshold. This report identifies deficiencies that meet the criteria for reporting to the DOE NTS; topics and subtopics that should remain under observation because the number of entries meets the test criteria or because of management concern; and topics and subtopics that are determined to no longer require observation. Topics and subtopics that are identified for continued observation are placed on a 'watch list.' The purpose of the watch list is for the Performance Analysis and Reporting Section (PARS) of the Contactor Assurance Office to analyze these topics and subtopics in future performance analysis reports.