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  1. Positron Emission Tomography (PET)

    DOE R&D Accomplishments [OSTI]

    Welch, M. J.

    1990-01-00

    Positron emission tomography (PET) assesses biochemical processes in the living subject, producing images of function rather than form. Using PET, physicians are able to obtain not the anatomical information provided by other medical imaging techniques, but pictures of physiological activity. In metaphoric terms, traditional imaging methods supply a map of the body's roadways, its, anatomy; PET shows the traffic along those paths, its biochemistry. This document discusses the principles of PET, the radiopharmaceuticals in PET, PET research, clinical applications of PET, the cost of PET, training of individuals for PET, the role of the United States Department of Energy in PET, and the futures of PET.

  2. SynchroPET LLC

    Broader source: Energy.gov [DOE]

    SynchroPET, based in Shoreham, New York, is a start-up biotech firm with the next generation of PET Scanners, which have superior imaging capabilities to what is currently available on the market today. SynchroPET's technology was developed at Brookhaven National Laboratory and it enabled SynchroPET to miniaturize the typical PET Scanner while improving its image. SynchroPET's technology can be paired with an existing MRI machine for a simultaneous image. These advances will accelerate the creation of new pharmaceuticals to treat cancers, and Alzheimer and Parkinson’s diseases. SynchroPET currently has four prototypes built, and each have been used by researchers from labs in New York.

  3. Policy on Pets on Campus Policy on Pets on Campus

    E-Print Network [OSTI]

    Sridhar, Srinivas

    Policy on Pets on Campus 10/30/2014 Policy on Pets on Campus I. Purpose and Scope The presence. This policy addresses pets on all property owned and controlled by the university and applies to all students. Policy The University prohibits pets in university-owned or leased buildings, except as provided below

  4. Pet Waste Management 

    E-Print Network [OSTI]

    Mechell, Justin; Lesikar, Bruce J.

    2008-08-28

    About 1 million pounds of dog waste is deposited daily in North Texas alone. That's why proper disposal of pet waste can make a big difference in the environment. 5 photos, 2 pages...

  5. ModPET: A Novel Small-Animal PET System Positron Emission Tomography (PET) and PET/CT systems have become the gold standard for imaging

    E-Print Network [OSTI]

    Arizona, University of

    for Gamma-Ray Imaging, we are developing a novel small-animal PET scanner that utilizes common modularModPET: A Novel Small-Animal PET System Positron Emission Tomography (PET) and PET/CT systems have these results to their human counterparts. Current small-animal PET scanners are very costly and complicated

  6. PetG and PetN, but not PetL, are essential subunits of the cytochrome b6f complex from Synechocystis PCC 6803

    E-Print Network [OSTI]

    Roegner, Matthias

    PetG and PetN, but not PetL, are essential subunits of the cytochrome b6f complex fromG, PetL, and PetN are essential for a cyanobacterial cytochrome b6f complex. We found that only PetL is dispensable, whereas PetG and PetN appear to be essential. Possible roles of the small cytochrome b6f complex

  7. Subunit IV-PetL chimeras in cytochrome b6f complex Chimeric fusions of subunit IV and PetL in the b6 f complex of

    E-Print Network [OSTI]

    IV-PetL chimeras in cytochrome b6 f complex Additional keywords : PetG, PetM, PetN, transmembrane- to unrecognized subunit, PetN ; vi) the ability to perform State Transitions is lost in the chi- meric mutants). Subunit PetN hither

  8. PET

    ScienceCinema (OSTI)

    None

    2011-04-25

    le DG fait l'introduction et laisse la parole à plusieurs intervenants au sujet de la physique des particules

  9. Combined PET/MRI scanner

    DOE Patents [OSTI]

    Schlyer, David (Bellport, NY); Woody, Craig L. (Setauket, NY); Rooney, William (Miller Place, NY); Vaska, Paul (Sound Beach, NY); Stoll, Sean (Wading River, NY); Pratte, Jean-Francois (Stony Brook, NY); O'Connor, Paul (Bellport, NY)

    2007-10-23

    A combined PET/MRI scanner generally includes a magnet for producing a magnetic field suitable for magnetic resonance imaging, a radiofrequency (RF) coil disposed within the magnetic field produced by the magnet and a ring tomograph disposed within the magnetic field produced by the magnet. The ring tomograph includes a scintillator layer for outputting at least one photon in response to an annihilation event, a detection array coupled to the scintillator layer for detecting the at least one photon outputted by the scintillator layer and for outputting a detection signal in response to the detected photon and a front-end electronic array coupled to the detection array for receiving the detection signal, wherein the front-end array has a preamplifier and a shaper network for conditioning the detection signal.

  10. Detector concept for OPET - A combined PET and optical Imaging system

    E-Print Network [OSTI]

    Prout, D L; Silverman, R W; Chatziioannou, A

    2004-01-01

    S. Schweitzer, “Cerium-doped lutetium oxy- orthosilicate: Aof microPET: A high-resolution lutetium oxyorthosilicate PET

  11. Modular strategies for PET imaging agents

    SciTech Connect (OSTI)

    Hooker, , J.M.

    2010-03-01

    In recent years, modular and simplified chemical and biological strategies have been developed for the synthesis and implementation of positron emission tomography (PET) radiotracers. New developments in bioconjugation and synthetic methodologies, in combination with advances in macromolecular delivery systems and gene-expression imaging, reflect a need to reduce radiosynthesis burden in order to accelerate imaging agent development. These new approaches, which are often mindful of existing infrastructure and available resources, are anticipated to provide a more approachable entry point for researchers interested in using PET to translate in vitro research to in vivo imaging.

  12. Analysis framework for the J-PET scanner

    E-Print Network [OSTI]

    Krzemie?, W; Gruntowski, A; Stola, K; Trybek, D; Bednarski, T; Bia?as, P; Czerwi?ski, E; Kami?ska, D; Kap?on, L; Kochanowski, A; Korcyl, G; Kowal, J; Kowalski, P; Kozik, T; Kubicz, E; Moskal, P; Nied?wiecki, Sz; Pa?ka, M; Raczy?ski, L; Rudy, Z; Salabura, P; Sharma, N G; Silarski, M; S?omski, A; Smyrski, J; Strzelecki, A; Wieczorek, A; Wi?licki, W; Zieli?ski, M; Zo?, N

    2015-01-01

    J-PET analysis framework is a flexible, lightweight, ROOT-based software package which provides the tools to develop reconstruction and calibration procedures for PET tomography. In this article we present the implementation of the full data-processing chain in the J-PET framework which is used for the data analysis of the J-PET tomography scanner. The Framework incorporates automated handling of PET setup parameters' database as well as high level tools for building data reconstruction procedures. Each of these components is briefly discussed.

  13. D 142 30 APRILE 2011 Boulder trovano spazio anche: Chris

    E-Print Network [OSTI]

    Finkelstein, Noah

    Tesla, completa- mente elettriche. «Eppure, il modo di vivere politically correct di Boulder è tutto

  14. PET/CT shielding design comparisons 

    E-Print Network [OSTI]

    Coker, Audra Lee

    2007-09-17

    used to calculate unattenuated radiation through existing lead walls. The computer code MCNPX was used to simulate the leaded walls of the PET/CT suite and provide another set of results. These two sets of results were compared to doses gathered from...

  15. Miniature 'Wearable' PET Scanner Ready for Use

    ScienceCinema (OSTI)

    Paul Vaska

    2013-07-22

    Scientists from BNL, Stony Brook University, and collaborators have demonstrated the efficacy of a "wearable," portable PET scanner they've developed for rats. The device will give neuroscientists a new tool for simultaneously studying brain function and behavior in fully awake, moving animals.

  16. The Dog Days of Summer - Capitalizing on the Pet Market

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    on the Pet Market July 9, 2015 Call Slides and Discussion Summary Agenda Call Logistics and Opening Poll 1 Introductions Residential Network and Peer Exchange Call...

  17. DEPARTMENT On the Web Exotic Pets: Health and

    E-Print Network [OSTI]

    Smith, Kate

    DEPARTMENT On the Web Exotic Pets: Health and Safety Issues for Children and Parents Kristine M pets, children, health, education, Web In the United States, persons in nearly 28 million households, or preparation of this manuscript. Conflicts of interest: None to report. Disclaimer: Reference to a Web site

  18. PET/NIR Imaging DOI: 10.1002/anie.201205271

    E-Print Network [OSTI]

    Cheng, Jianjun

    PET/NIR Imaging DOI: 10.1002/anie.201205271 Aptamer-Functionalized, Ultra-Small, Monodisperse staging.[5] Various techniques for sentinel LN imaging have been investigated, such as near-infrared (NIR of monodisperse, size-controlled silica NC probes for dual- modal LN imaging using PET and NIR fluorescence. Mono

  19. Registration of PET and MR hand volumes using Bayesian Networks

    E-Print Network [OSTI]

    Magee, Derek

    Registration of PET and MR hand volumes using Bayesian Networks Derek Magee1 , Steven Tanner1 , Michael Waller2 , Dennis McGonagle2 , and Alan P. Jeavons1 1 School of Computing/Academic Unit of Medical is presented. PET and MR scans are aligned by optimising the configuration of a tube based model using a set

  20. An improved analytical detector response function model for multilayer small-diameter PET scanners

    E-Print Network [OSTI]

    Strul, D; Slates, R B; Dahlbom, M; Cherry, Simon R; Marsden, P K

    2003-01-01

    of microPET: a high-resolution lutetium oxyorthosilicate PETlayer, scanners employing lutetium oxyorthosilicate (LSO)

  1. High-Resolution PET Detector. Final report

    SciTech Connect (OSTI)

    Karp, Joel

    2014-03-26

    The objective of this project was to develop an understanding of the limits of performance for a high resolution PET detector using an approach based on continuous scintillation crystals rather than pixelated crystals. The overall goal was to design a high-resolution detector, which requires both high spatial resolution and high sensitivity for 511 keV gammas. Continuous scintillation detectors (Anger cameras) have been used extensively for both single-photon and PET scanners, however, these instruments were based on NaI(Tl) scintillators using relatively large, individual photo-multipliers. In this project we investigated the potential of this type of detector technology to achieve higher spatial resolution through the use of improved scintillator materials and photo-sensors, and modification of the detector surface to optimize the light response function.We achieved an average spatial resolution of 3-mm for a 25-mm thick, LYSO continuous detector using a maximum likelihood position algorithm and shallow slots cut into the entrance surface.

  2. STRIP-PET: a novel detector concept for the TOF-PET scanner

    E-Print Network [OSTI]

    Moskal, P; Bia?as, P; Ciszewska, M; Czerwi?ski, E; Heczko, A; Kajetanowicz, M; Kap?on, ?; Kochanowski, A; Konopka-Cupia?, G; Korcyl, G; Krzemie?, W; ?ojek, K; Majewski, J; Migda?, W; Molenda, M; Nied?wiecki, Sz; Pa?ka, M; Rudy, Z; Salabura, P; Silarski, M; S?omski, A; Smyrski, J; Zdebik, J; Zieli?ski, M

    2013-01-01

    We briefly present a design of a new PET scanner based on strips of polymer scintillators arranged in a barrel constituting a large acceptance detector. The solution proposed is based on the superior timing properties of the polymer scintillators. The position and time of the reaction of the gamma quanta in the detector material will be determined based on the time of arrival of light signals to the edges of the scintillator strips.

  3. MicroPET II: design, development and initial performance of an improved microPET scanner for small-animal imaging

    E-Print Network [OSTI]

    2003-01-01

    of microPET: a high-resolution lutetium oxyorthosilicate PETof an array of 14 × 14 lutetium oxyorthosilicate (LSO)

  4. Database and data structure for the novel TOF-PET detector developed for J-PET project

    E-Print Network [OSTI]

    Czerwi?ski, E; Bednarski, T; Bia?as, P; Kap?on, ?; Kochanowski, A; Korcyl, G; Kowal, J; Kowalski, P; Kozik, T; Krzemie?, W; Kubicz, E; Molenda, M; Moskal, P; Nied?wiecki, Sz; Pa?ka, M; Pawlik, M; Raczy?ski, L; Rudy, Z; Salabura, P; Sharma, N G; Silarski, M; S?omski, A; Smyrski, J; Strzelecki, A; Wieczorek, A; Wi?licki, W; Zo?, N

    2014-01-01

    The complexity of the hardware and the amount of data collected during the PET imaging process require application of modern methods of efficient data organization and processing. In this article we will discuss the data structures and the flow of collected data from the novel TOF-PET medical scanner which is being developed at the Jagiellonian University. The developed data format reflects: registration process of the gamma quanta emitted from positron-electron annihilation, Front-End Electronic (FEE) structure and required input information for the image reconstruction. In addition, the system database fulfills possible demands of the evolving J-PET project.

  5. Simultaneous PET/fMRI for imaging neuroreceptor dynamics

    E-Print Network [OSTI]

    Sander, Christin Y. (Christin Yen-Ming)

    2014-01-01

    Whole-brain neuroimaging is a key technique for studying brain function and connectivity. Recent advances in combining two imaging modalities - magnetic resonance imaging (MRI) and positron emission tomography (PET) - into ...

  6. Intrinsic Radiation in Lutetium Based PET Detector: Advantages and Disadvantages

    E-Print Network [OSTI]

    Wei, Qingyang

    2015-01-01

    Lutetium (Lu) based scintillators such as LSO and LYSO, are widely used in modern PET detectors due to their high stopping power for 511 keV gamma rays, high light yield and short decay time. However, 2.6% of naturally occurring Lu is 176Lu, a long-lived radioactive element including a beta decay and three major simultaneous gamma decays. This phenomenon introduces random events to PET systems that affects the system performance. On the other hand, the advantages of intrinsic radiation of 176Lu (IRL) continues to be exploited. In this paper, research literatures about IRL in PET detectors are reviewed. Details about the adverse effects of IRL to PET and their solutions, as well as the useful applications are presented and discussed.

  7. MR-based motion correction for PET imaging using wired active MR microcoils in simultaneous PET-MR: Phantom study

    SciTech Connect (OSTI)

    Huang, Chuan; Brady, Thomas J.; El Fakhri, Georges; Ouyang, Jinsong; Ackerman, Jerome L.; Petibon, Yoann

    2014-04-15

    Purpose: Artifacts caused by head motion present a major challenge in brain positron emission tomography (PET) imaging. The authors investigated the feasibility of using wired active MR microcoils to track head motion and incorporate the measured rigid motion fields into iterative PET reconstruction. Methods: Several wired active MR microcoils and a dedicated MR coil-tracking sequence were developed. The microcoils were attached to the outer surface of an anthropomorphic{sup 18}F-filled Hoffman phantom to mimic a brain PET scan. Complex rotation/translation motion of the phantom was induced by a balloon, which was connected to a ventilator. PET list-mode and MR tracking data were acquired simultaneously on a PET-MR scanner. The acquired dynamic PET data were reconstructed iteratively with and without motion correction. Additionally, static phantom data were acquired and used as the gold standard. Results: Motion artifacts in PET images were effectively removed by wired active MR microcoil based motion correction. Motion correction yielded an activity concentration bias ranging from ?0.6% to 3.4% as compared to a bias ranging from ?25.0% to 16.6% if no motion correction was applied. The contrast recovery values were improved by 37%–156% with motion correction as compared to no motion correction. The image correlation (mean ± standard deviation) between the motion corrected (uncorrected) images of 20 independent noise realizations and static reference was R{sup 2} = 0.978 ± 0.007 (0.588 ± 0.010, respectively). Conclusions: Wired active MR microcoil based motion correction significantly improves brain PET quantitative accuracy and image contrast.

  8. Leaching of antimony from polyethylene terephthalate (PET) bottles into mineral water

    E-Print Network [OSTI]

    Short, Daniel

    Leaching of antimony from polyethylene terephthalate (PET) bottles into mineral water Szilvia April 2009 Available online 21 May 2009 Keywords: Antimony Water Leaching Polyethylene terephthalate SODIS The Sb leaching from polyethylene terephthalate (PET) package material into 10 different brands

  9. OFFICIAL POLICY 6.1.3 Policy on Pets on Campus 4/22/2014

    E-Print Network [OSTI]

    Kunkle, Tom

    OFFICIAL POLICY 6.1.3 Policy on Pets on Campus 4/22/2014 Policy Statement 1.0 BUILDINGS AND OFFICES, "College"), unless allowed under the terms of Section 4.0 of this Policy. 2.0 COLLEGE GROUNDS Pets are permitted on campus grounds, subject to the terms of this Policy. Pets brought on campus grounds

  10. SYNTHESIS OF DIVERSE TRACERS ON EWOD MICRODEVICE FOR POSITRON EMISSION TOMOGRAPHY (PET)

    E-Print Network [OSTI]

    , spatial, and temporal measurement of biochemical processes. Applications of PET include studying disease-labeled PET tracers with electrowetting-on-dielectric (EWOD) technology [3],[4], the digital microfluidicSYNTHESIS OF DIVERSE TRACERS ON EWOD MICRODEVICE FOR POSITRON EMISSION TOMOGRAPHY (PET) S. Chen1

  11. Processing optimization with parallel computing for the J-PET tomography scanner

    E-Print Network [OSTI]

    Krzemie?, W; Bednarski, T; Bia?as, P; Czerwi?ski, E; Gajos, A; Gorgol, M; Jasi?ska, B; Kami?ska, D; Kap?on, ?; Korcyl, G; Kowalski, P; Kozik, T; Kubicz, E; Nied?wiecki, Sz; Pa?ka, M; Raczy?ski, L; Rudy, Z; Rundel, O; Sharma, N G; Silarski, M; S?omski, A; Stola, K; Strzelecki, A; Trybek, D; Wieczorek, Anna; Wi?licki, W; Zieli?ski, M; Zgardzi?ska, B K; Moskal, P

    2015-01-01

    The Jagiellonian-PET (J-PET) collaboration is developing a prototype TOF-PET detector based on long polymer scintillators. This novel approach exploits the excellent time properties of the plastic scintillators, which permit very precise time measurements. The very fast, FPGA-based front-end electronics and the data acquisition system, as well as, low- and high-level reconstruction algorithms were specially developed to be used with the J-PET scanner. The TOF-PET data processing and reconstruction are time and resource demanding operations, especially in case of a large acceptance detector, which works in triggerless data acquisition mode. In this article, we discuss the parallel computing methods applied to optimize the data processing for the J-PET detector. We begin with general concepts of parallel computing and then we discuss several applications of those techniques in the J-PET data processing.

  12. PET: Reducing Database Energy Cost via Query Optimization

    E-Print Network [OSTI]

    Tu, Yicheng

    PET: Reducing Database Energy Cost via Query Optimization Zichen Xu The Ohio State University xuz a cost-based query optimizer that eval- uates query plans by both performance and energy costs. By fol can achieve a good understanding of the energy- related query optimization and cost-based plan

  13. PET Evaluation of Novel Radiofluorinated Reboxetine Analogs as Norepinephrine

    E-Print Network [OSTI]

    Pike, Victor W.

    in all examined regions to near unity (e.g., to a ratio of 1.03 in mesencephalon). Labeled metabolites positron emission tomography (PET). A previous evaluation of a carbon-11 (t1/2 20.4 min) labelled O with a somewhat noisy final signal, Contract grant sponsor: KI-NIH graduate training partnership. *Correspondence

  14. Modeling of material response during fiber drawing of semicrystalline pet 

    E-Print Network [OSTI]

    Yadav, Seemant

    2007-09-17

    'Neal May 2006 Major Subject: Mechanical Engineering iii ABSTRACT Modeling of Material Response during Fiber Drawing of Semicrystalline PET. (May 2006) Seemant Yadav, B.E., Shri Govindram Seksaria Institute of Technology and Science, Indore... Seksaria Institute of Technology and Science, Indore, India. Bachelor of Engineering, Mechanical Engineering ...

  15. TOF-PET Imaging within the Framework of Sparse Reconstruction 

    E-Print Network [OSTI]

    Lao, Dapeng

    2012-07-16

    Page 1-1 Diagram describing of the Radon transformation where the red line denotes the LOR (line of response) and the ROI (region of interest) is discretized into n?n pixels...-1. The relationship between the object of interest ),( yxf and PET observed data ),( sp ? can be formally represented via the well-known Radon transformation [28], namely, ?? ??= dxdyxysyxfsp ))sincos...

  16. Overview of the software architecture and data flow for the J-PET tomography device

    E-Print Network [OSTI]

    Krzemien, W; Bialas, P; Czerwinski, E; Gajos, A; Gruntowski, A; Gruntowski, T; Kaplon, L; Kochanowski, A; Korcyl, G; Kowal, J; Kowalski, P; Kozik, T; Kubicz, E; Moskal, P; Niedzwiecki, Sz; Palka, M; Raczynski, L; Rudy, Z; Sharma, N G; Silarski, M; Slomski, A; Stola, K; Strzelecki, A; Trybek, D; Wieczorek, A; Zielinski, M; Wislicki, W; Zon, N

    2015-01-01

    Modern TOF-PET scanner systems require high-speed computing resources for efficient data processing, monitoring and image reconstruction. In this article we present the data flow and software architecture for the novel TOF-PET scanner developed by the J-PET collaboration. We discuss the data acquisition system, reconstruction framework and some image reconstruction issues. Also, the concept of computing outside hospitals in the remote centers such as \\'Swierk Computing Centre in Poland is presented.

  17. Compact and mobile high resolution PET brain imager

    DOE Patents [OSTI]

    Majewski, Stanislaw (Yorktown, VA); Proffitt, James (Newport News, VA)

    2011-02-08

    A brain imager includes a compact ring-like static PET imager mounted in a helmet-like structure. When attached to a patient's head, the helmet-like brain imager maintains the relative head-to-imager geometry fixed through the whole imaging procedure. The brain imaging helmet contains radiation sensors and minimal front-end electronics. A flexible mechanical suspension/harness system supports the weight of the helmet thereby allowing for patient to have limited movements of the head during imaging scans. The compact ring-like PET imager enables very high resolution imaging of neurological brain functions, cancer, and effects of trauma using a rather simple mobile scanner with limited space needs for use and storage.

  18. AUTOMATION FOR THE SYNTHESIS AND APPLICATION OF PET RADIOPHARMACEUTICALS.

    SciTech Connect (OSTI)

    Alexoff, D.L.

    2001-09-21

    The development of automated systems supporting the production and application of PET radiopharmaceuticals has been an important focus of researchers since the first successes of using carbon-11 (Comar et al., 1979) and fluorine-18 (Reivich et al., 1979) labeled compounds to visualize functional activity of the human brain. These initial successes of imaging the human brain soon led to applications in the human heart (Schelbert et al., 1980), and quickly radiochemists began to see the importance of automation to support PET studies in humans (Lambrecht, 1982; Langstrom et al., 1983). Driven by the necessity of controlling processes emanating high fluxes of 511 KeV photons, and by the tedium of repetitive syntheses for carrying out these human PET investigations, academic and government scientists have designed, developed and tested many useful and novel automated systems in the past twenty years. These systems, originally designed primarily by radiochemists, not only carry out effectively the tasks they were designed for, but also demonstrate significant engineering innovation in the field of laboratory automation.

  19. The effects of demographics and pet ownership on attachment towards and opinion about owned and unowned free-roaming cats 

    E-Print Network [OSTI]

    Ramon, Melanie Elaine

    2009-05-15

    A telephone questionnaire was developed to collect information on pet owners, cat ownership patterns, and people's opinions about homeless pets. A 7-day observation log was also developed to gather information about free-roaming cats in Caldwell, TX...

  20. Validation of a 4D-PET Maximum Intensity Projection for Delineation of an Internal Target Volume

    SciTech Connect (OSTI)

    Callahan, Jason; Kron, Tomas; Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne ; Schneider-Kolsky, Michal; Dunn, Leon; Thompson, Mick; Siva, Shankar; Aarons, Yolanda; Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne ; Binns, David; Hicks, Rodney J.; Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne

    2013-07-15

    Purpose: The delineation of internal target volumes (ITVs) in radiation therapy of lung tumors is currently performed by use of either free-breathing (FB) {sup 18}F-fluorodeoxyglucose-positron emission tomography-computed tomography (FDG-PET/CT) or 4-dimensional (4D)-CT maximum intensity projection (MIP). In this report we validate the use of 4D-PET-MIP for the delineation of target volumes in both a phantom and in patients. Methods and Materials: A phantom with 3 hollow spheres was prepared surrounded by air then water. The spheres and water background were filled with a mixture of {sup 18}F and radiographic contrast medium. A 4D-PET/CT scan was performed of the phantom while moving in 4 different breathing patterns using a programmable motion device. Nine patients with an FDG-avid lung tumor who underwent FB and 4D-PET/CT and >5 mm of tumor motion were included for analysis. The 3 spheres and patient lesions were contoured by 2 contouring methods (40% of maximum and PET edge) on the FB-PET, FB-CT, 4D-PET, 4D-PET-MIP, and 4D-CT-MIP. The concordance between the different contoured volumes was calculated using a Dice coefficient (DC). The difference in lung tumor volumes between FB-PET and 4D-PET volumes was also measured. Results: The average DC in the phantom using 40% and PET edge, respectively, was lowest for FB-PET/CT (DCAir = 0.72/0.67, DCBackground 0.63/0.62) and highest for 4D-PET/CT-MIP (DCAir = 0.84/0.83, DCBackground = 0.78/0.73). The average DC in the 9 patients using 40% and PET edge, respectively, was also lowest for FB-PET/CT (DC = 0.45/0.44) and highest for 4D-PET/CT-MIP (DC = 0.72/0.73). In the 9 lesions, the target volumes of the FB-PET using 40% and PET edge, respectively, were on average 40% and 45% smaller than the 4D-PET-MIP. Conclusion: A 4D-PET-MIP produces volumes with the highest concordance with 4D-CT-MIP across multiple breathing patterns and lesion sizes in both a phantom and among patients. Freebreathing PET/CT consistently underestimates ITV when compared with 4D PET/CT for a lesion affected by respiration.

  1. Chimeric Fusions of Subunit IV and PetL in the b6 f Complex of Chlamydomonas reinhardtii

    E-Print Network [OSTI]

    - unit, PetN; and (vi) the ability to perform state transi- tions is lost in the chimeric mutants in C. reinhardtii (3, 5, 6, 8), in higher plants (6), and in cyanobacteria (9). Subunit PetN hith- erto in C. reinhardtii (12) or of the petN gene in tobacco (10) prevents accumulation of the b6 f complex

  2. IEEE TRANSACTIONS ON NUCLEAR SCIENCE, VOL. 51, NO. 1, FEBRUARY 2004 85 Optimal Calibration of PET Crystal Position Maps

    E-Print Network [OSTI]

    Johnson, Michael T.

    for a positron emission tomography (PET) scanner consists of a 2-D array of scintillation crystals coupled, IEEE Abstract--A method is developed for estimating optimal PET gamma-ray detector crystal position liklihood estimation, positron emission tomography (PET). I. INTRODUCTION Acommon detector configuration

  3. A Central Positron Source to Perform the Timing Alignment of Detectors in a PET

    E-Print Network [OSTI]

    Thompson, Chris

    . The time delay before the gamma ray is detected by the scanner's conventional gamma ray detectors An essential calibration procedure for a positron emission tomography (PET) scanner is the compensation a precise time reference. Aligning the detectors in a PET scanner so that they can detect coincident gamma

  4. INDEPENDENT COMPONENT ANALYSIS AND BEYOND IN BRAIN IMAGING: EEG, MEG, FMRI, AND PET

    E-Print Network [OSTI]

    Vialatte, François

    Technological University, Singapore ¾ Laboratory of Advanced Brain Signal Processing, Brain Science Institute applications of ICA in processing brain imaging signals: EEG, MEG, fMRI or PET. We highlight the current issuesINDEPENDENT COMPONENT ANALYSIS AND BEYOND IN BRAIN IMAGING: EEG, MEG, FMRI, AND PET Jagath C

  5. Dual energy CT for attenuation correction with PET/CT

    SciTech Connect (OSTI)

    Xia, Ting; Alessio, Adam M.; Kinahan, Paul E.

    2014-01-15

    Purpose: The authors evaluate the energy dependent noise and bias properties of monoenergetic images synthesized from dual-energy CT (DECT) acquisitions. These monoenergetic images can be used to estimate attenuation coefficients at energies suitable for positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging. This is becoming more relevant with the increased use of quantitative imaging by PET/CT and SPECT/CT scanners. There are, however, potential variations in the noise and bias of synthesized monoenergetic images as a function of energy. Methods: The authors used analytic approximations and simulations to estimate the noise and bias of synthesized monoenergetic images of water-filled cylinders with different shapes and the NURBS-based cardiac-torso (NCAT) phantom from 40 to 520 keV, the range of SPECT and PET energies. The dual-kVp spectra were based on the GE Lightspeed VCT scanner at 80 and 140 kVp with added filtration of 0.5 mm Cu. The authors evaluated strategies of noise suppression with sinogram smoothing and dose minimization with reduction of tube currents at the two kVp settings. The authors compared the impact of DECT-based attenuation correction with single-kVp CT-based attenuation correction on PET quantitation for the NCAT phantom for soft tissue and high-Z materials of bone and iodine contrast enhancement. Results: Both analytic calculations and simulations displayed the expected minimum noise value for a synthesized monoenergetic image at an energy between the mean energies of the two spectra. In addition the authors found that the normalized coefficient of variation in the synthesized attenuation map increased with energy but reached a plateau near 160 keV, and then remained constant with increasing energy up to 511 keV and beyond. The bias was minimal, as the linear attenuation coefficients of the synthesized monoenergetic images were within 2.4% of the known true values across the entire energy range. Compared with no sinogram smoothing, sinogram smoothing can dramatically reduce noise in the DECT-derived attenuation map. Through appropriate selection of tube currents for high and low kVp scans, DECT can deliver roughly the same amount of radiation dose as that of a single kVp CT scan, but could be used for PET attenuation correction with reduced bias in contrast agent regions by a factor of ?2.6 and slightly reduced RMSE for the total image. Conclusions: When DECT is used for attenuation correction at higher energies, there is a noise amplification that is dependent on the energy of the synthesized monoenergetic image of linear attenuation coefficients. Sinogram smoothing reduces the noise amplification in DECT-derived attenuation maps without increasing bias. With an appropriate selection of CT techniques, a DECT scan with the same radiation dose as a single CT scan can result in a PET image with improved quantitative accuracy.

  6. Evaluation of the spline reconstruction technique for PET

    SciTech Connect (OSTI)

    Kastis, George A. Kyriakopoulou, Dimitra; Gaitanis, Anastasios; Fernández, Yolanda; Hutton, Brian F.; Fokas, Athanasios S.

    2014-04-15

    Purpose: The spline reconstruction technique (SRT), based on the analytic formula for the inverse Radon transform, has been presented earlier in the literature. In this study, the authors present an improved formulation and numerical implementation of this algorithm and evaluate it in comparison to filtered backprojection (FBP). Methods: The SRT is based on the numerical evaluation of the Hilbert transform of the sinogram via an approximation in terms of “custom made” cubic splines. By restricting reconstruction only within object pixels and by utilizing certain mathematical symmetries, the authors achieve a reconstruction time comparable to that of FBP. The authors have implemented SRT in STIR and have evaluated this technique using simulated data from a clinical positron emission tomography (PET) system, as well as real data obtained from clinical and preclinical PET scanners. For the simulation studies, the authors have simulated sinograms of a point-source and three digital phantoms. Using these sinograms, the authors have created realizations of Poisson noise at five noise levels. In addition to visual comparisons of the reconstructed images, the authors have determined contrast and bias for different regions of the phantoms as a function of noise level. For the real-data studies, sinograms of an{sup 18}F-FDG injected mouse, a NEMA NU 4-2008 image quality phantom, and a Derenzo phantom have been acquired from a commercial PET system. The authors have determined: (a) coefficient of variations (COV) and contrast from the NEMA phantom, (b) contrast for the various sections of the Derenzo phantom, and (c) line profiles for the Derenzo phantom. Furthermore, the authors have acquired sinograms from a whole-body PET scan of an {sup 18}F-FDG injected cancer patient, using the GE Discovery ST PET/CT system. SRT and FBP reconstructions of the thorax have been visually evaluated. Results: The results indicate an improvement in FWHM and FWTM in both simulated and real point-source studies. In all simulated phantoms, the SRT exhibits higher contrast and lower bias than FBP at all noise levels, by increasing the COV in the reconstructed images. Finally, in real studies, whereas the contrast of the cold chambers are similar for both algorithms, the SRT reconstructed images of the NEMA phantom exhibit slightly higher COV values than those of FBP. In the Derenzo phantom, SRT resolves the 2-mm separated holes slightly better than FBP. The small-animal and human reconstructions via SRT exhibit slightly higher resolution and contrast than the FBP reconstructions. Conclusions: The SRT provides images of higher resolution, higher contrast, and lower bias than FBP, by increasing slightly the noise in the reconstructed images. Furthermore, it eliminates streak artifacts outside the object boundary. Unlike other analytic algorithms, the reconstruction time of SRT is comparable with that of FBP. The source code for SRT will become available in a future release of STIR.

  7. Lanthanum halide scintillators for time-of-flight 3-D pet

    DOE Patents [OSTI]

    Karp, Joel S. (Glenside, PA); Surti, Suleman (Philadelphia, PA)

    2008-06-03

    A Lanthanum Halide scintillator (for example LaCl.sub.3 and LaBr.sub.3) with fast decay time and good timing resolution, as well as high light output and good energy resolution, is used in the design of a PET scanner. The PET scanner includes a cavity for accepting a patient and a plurality of PET detector modules arranged in an approximately cylindrical configuration about the cavity. Each PET detector includes a Lanthanum Halide scintillator having a plurality of Lanthanum Halide crystals, a light guide, and a plurality of photomultiplier tubes arranged respectively peripherally around the cavity. The good timing resolution enables a time-of-flight (TOF) PET scanner to be developed that exhibits a reduction in noise propagation during image reconstruction and a gain in the signal-to-noise ratio. Such a PET scanner includes a time stamp circuit that records the time of receipt of gamma rays by respective PET detectors and provides timing data outputs that are provided to a processor that, in turn, calculates time-of-flight (TOF) of gamma rays through a patient in the cavity and uses the TOF of gamma rays in the reconstruction of images of the patient.

  8. Initial PET Performance Evaluation of a Preclinical Insert for PET/MRI with Digital SiPM Technology

    E-Print Network [OSTI]

    Schug, David; Weissler, Bjoern; Gebhardt, Pierre; Goldschmidt, Benjamin; Wehner, Jakob; Dueppenbecker, Peter Michael; Salomon, Andre; Hallen, Patrick; Kiessling, Fabian; Schulz, Volkmar

    2015-01-01

    Hyperion-IID is a positron emission tomography (PET) insert which allows simultaneous operation in a clinical magnetic resonance imaging (MRI) scanner. To read out the scintillation light of the employed LYSO crystal arrays with a pitch of 1 mm pitch and 12 mm in height, digital silicon photomultipliers (DPC 3200-22, Philips Digital Photon Counting) (DPC) are used. The basic PET performance in terms of energy resolution, coincidence resolution time (CRT) and sensitivity as a function of operating parameters, such as the operating temperature, the applied overvoltage, activity and configuration parameters of the DPCs, were evaluated on system level. The measured energy resolution did not show a large dependency on the selected parameters and is in the range of 12.4-12.9% for low activities and degrades to ~13.6% at activities of ~100 MBq. The CRT strongly depends on the selected trigger scheme (trig) of the DPCs. We measured approximately 260 ps, 440 ps, 540 ps and 1300 ps for trig 1-4, respectively. The trues...

  9. High resolution PET breast imager with improved detection efficiency

    DOE Patents [OSTI]

    Majewski, Stanislaw

    2010-06-08

    A highly efficient PET breast imager for detecting lesions in the entire breast including those located close to the patient's chest wall. The breast imager includes a ring of imaging modules surrounding the imaged breast. Each imaging module includes a slant imaging light guide inserted between a gamma radiation sensor and a photodetector. The slant light guide permits the gamma radiation sensors to be placed in close proximity to the skin of the chest wall thereby extending the sensitive region of the imager to the base of the breast. Several types of photodetectors are proposed for use in the detector modules, with compact silicon photomultipliers as the preferred choice, due to its high compactness. The geometry of the detector heads and the arrangement of the detector ring significantly reduce dead regions thereby improving detection efficiency for lesions located close to the chest wall.

  10. Post-injection transmission attenuation measurements for PET

    SciTech Connect (OSTI)

    Daube-Witherspoon, M.E.; Carson, R.E.; Green, M.V.

    1988-02-01

    The feasibility of acquiring PET transmission information after tracer injection was studied using ring and rotating pin transmission sources. A combined transmission/emission scan was acquired, followed by an emission scan, used to subtract the emission counts from the transmission/emission data. The ratio of emission count rate for FDG brain scans to transmission count rate is 50-100% for a 5-mCi ring source and less than 5% for a 5-mCi pin source. Windowing of the sinogram, which rejects most random and scattered coincidences, also eliminates most emission counts. The magnitude and effects of residual random and scattered coincidences as well as increases in variability from tranmission/emission scans were studied. In addition, the results of combined transmission/emission scans for a high-contrast emission source distribution using ring and pin sources are described.

  11. Dosimetry of Y-90 Liquid Brachytherapy in a Dog with Osteosarcoma Using PET/CT 

    E-Print Network [OSTI]

    Zhou, Jingjie

    2011-08-08

    receive a total dose of over 1000 Gy. Y-90 liquid brachytherapy has the potential to be used as an adjuvant therapy or for palliation purposes. Future work includes evaluation of pharmacokinetics of the Y-90 radiopharmaceutical, calibration of PET...

  12. F-18 Labeled Diabody-Luciferase Fusion Proteins for Optical-ImmunoPET

    SciTech Connect (OSTI)

    Wu, Anna M

    2013-01-18

    The goal of the proposed work is to develop novel dual-labeled molecular imaging probes for multimodality imaging. Based on small, engineered antibodies called �diabodies�, these probes will be radioactively tagged with Fluorine-18 for PET imaging, and fused to luciferases for optical (bioluminescence) detection. Performance will be evaluated and validated using a prototype integrated optical-PET imaging system, OPET. Multimodality probes for optical-PET imaging will be based on diabodies that are dually labeled with 18F for PET detection and fused to luciferases for optical imaging. 1) Two sets of fusion proteins will be built, targeting the cell surface markers CEA or HER2. Coelenterazine-based luciferases and variant forms will be evaluated in combination with native substrate and analogs, in order to obtain two distinct probes recognizing different targets with different spectral signatures. 2) Diabody-luciferase fusion proteins will be labeled with 18F using amine reactive [18F]-SFB produced using a novel microwave-assisted, one-pot method. 3) Sitespecific, chemoselective radiolabeling methods will be devised, to reduce the chance that radiolabeling will inactivate either the target-binding properties or the bioluminescence properties of the diabody-luciferase fusion proteins. 4) Combined optical and PET imaging of these dual modality probes will be evaluated and validated in vitro and in vivo using a prototype integrated optical-PET imaging system, OPET. Each imaging modality has its strengths and weaknesses. Development and use of dual modality probes allows optical imaging to benefit from the localization and quantitation offered by the PET mode, and enhances the PET imaging by enabling simultaneous detection of more than one probe.

  13. Alkyd-amino resins based on waste PET for coating applications

    SciTech Connect (OSTI)

    Torlakoglu, A. [Department of Chemical Engineering, Faculty of Engineering, Istanbul University, 34320 Avcilar, Istanbul (Turkey); Gueclue, G. [Department of Chemical Engineering, Faculty of Engineering, Istanbul University, 34320 Avcilar, Istanbul (Turkey)], E-mail: gguclu@istanbul.edu.tr

    2009-01-15

    Waste polyethylene terephthalate (PET) flakes were depolymerized by using propylene glycol (PG) in the presence of zinc acetate as catalyst. Glycolysis reaction products of waste PET obtained by using PET/glycol molar ratio 1/2. Two short oil alkyd resins of high acid values (30-40 mgKOH/g) were prepared from phthalic anhydride (PA), glycerin (G), coconut oil fatty acids (COFA) and glycolyzed products of waste PET (PET-based alkyd resins) or glycols (PG) (reference alkyd resins). These alkyd resins were blended with 30%, 40%, and 50% of a commercial urea-formaldehyde, melamine-formaldehyde and urea-formaldehyde/melamine-formaldehyde mixture (1/1 weight ratio) and heated at 140 deg. C. The physical and chemical properties such as drying time, hardness, abrasion resistance, adhesion strength, water resistance, alkaline resistance, acid resistance, gelation time, and thermal oxidative degradation resistance (with thermogravimetric analysis, TGA) of these alkyd-amino resins were investigated. The properties of the waste PET-based resins were found to be compatible with the properties of the reference resins.

  14. Estimated cumulative radiation dose from PET/CT in children with malignancies: a 5-year retrospective review

    E-Print Network [OSTI]

    2010-01-01

    both PET and CT studies. The ALARA principle must be appliedprotocols that follow the ALARA principle (as low asis necessary to apply the ALARA principle in the radiation

  15. Fabrication and characterization of a 0.5-mm lutetium oxyorthosilicate detector array for high-resolution PET applications

    E-Print Network [OSTI]

    Stickel, Jennifer R; Qi, Jinyi; Cherry, Simon R

    2007-01-01

    and Characterization of a 0.5-mm Lutetium OxyorthosilicateIn this work, a pair of lutetium oxyorthosi- licate (LSO)PET; high spatial resolution; lutetium oxyorthosilicate;

  16. Ultralow dose computed tomography attenuation correction for pediatric PET CT using adaptive statistical iterative reconstruction

    SciTech Connect (OSTI)

    Brady, Samuel L.; Shulkin, Barry L.

    2015-02-15

    Purpose: To develop ultralow dose computed tomography (CT) attenuation correction (CTAC) acquisition protocols for pediatric positron emission tomography CT (PET CT). Methods: A GE Discovery 690 PET CT hybrid scanner was used to investigate the change to quantitative PET and CT measurements when operated at ultralow doses (10–35 mA s). CT quantitation: noise, low-contrast resolution, and CT numbers for 11 tissue substitutes were analyzed in-phantom. CT quantitation was analyzed to a reduction of 90% volume computed tomography dose index (0.39/3.64; mGy) from baseline. To minimize noise infiltration, 100% adaptive statistical iterative reconstruction (ASiR) was used for CT reconstruction. PET images were reconstructed with the lower-dose CTAC iterations and analyzed for: maximum body weight standardized uptake value (SUV{sub bw}) of various diameter targets (range 8–37 mm), background uniformity, and spatial resolution. Radiation dose and CTAC noise magnitude were compared for 140 patient examinations (76 post-ASiR implementation) to determine relative dose reduction and noise control. Results: CT numbers were constant to within 10% from the nondose reduced CTAC image for 90% dose reduction. No change in SUV{sub bw}, background percent uniformity, or spatial resolution for PET images reconstructed with CTAC protocols was found down to 90% dose reduction. Patient population effective dose analysis demonstrated relative CTAC dose reductions between 62% and 86% (3.2/8.3–0.9/6.2). Noise magnitude in dose-reduced patient images increased but was not statistically different from predose-reduced patient images. Conclusions: Using ASiR allowed for aggressive reduction in CT dose with no change in PET reconstructed images while maintaining sufficient image quality for colocalization of hybrid CT anatomy and PET radioisotope uptake.

  17. Performance of three-photon PET imaging: Monte Carlo simulations

    E-Print Network [OSTI]

    Kacperski, K; Kacperski, Krzysztof; Spyrou, Nicholas M.

    2005-01-01

    We have recently introduced the idea of making use of three-photon positron annihilations in positron emission tomography. In this paper the basic characteristics of the three-gamma imaging in PET are studied by means of Monte Carlo simulations and analytical computations. Two typical configurations of human and small animal scanners are considered. Three-photon imaging requires high energy resolution detectors. Parameters currently attainable by CdZnTe semiconductor detectors, the technology of choice for the future development of radiation imaging, are assumed. Spatial resolution is calculated as a function of detector energy resolution and size, position in the field of view, scanner size, and the energies of the three gamma annihilation photons. Possible ways to improve the spatial resolution obtained for nominal parameters: 1.5 cm and 3.2 mm FWHM for human and small animal scanners, respectively, are indicated. Counting rates of true and random three-photon events for typical human and small animal scann...

  18. Are Plastic Toys Hurting Our Pets? | Care2 Causes http://www.care2.com/causes/are-plastic-toys-hurting-our-pets.html[12/6/2012 8:12:04 AM

    E-Print Network [OSTI]

    Rock, Chris

    Are Plastic Toys Hurting Our Pets? | Care2 Causes http://www.care2.com/causes/are-plastic:00 pm 28 4 0 43 Are Plastic Toys Hurting Our Pets? A new study from Texas Tech University has found that plastic toys, such as bumper toys used for training, may be exposing our dogs to harmful chemicals

  19. Preventive maintenance system for the photomultiplier detector blocks of pet scanners

    DOE Patents [OSTI]

    Levy, Alejandro V. (Center Moriches, NY); Warner, Donald (Shirley, NY)

    1995-01-24

    A system including a method and apparatus for preventive maintenance of PET scanner photomultiplier detector blocks is disclosed. The quantitive comparisons used in the method of the present invention to provide an indication in the form of a display or printout advising the user that the photomultiplier block is stable, intermittently unstable, or drifting unstable, and also advising of the expected date of failure of a photomultiplier block in the PET scanner. The system alerts the user to replace the defective photomultiplier block prior to catastrophic failure in a scheduled preventative maintenance program, thus eliminating expensive and unscheduled downtime of the PET scanner due to photomultiplier failure. The apparatus for carrying out the method of the present invention preferably resides in the host computer controlling a PET scanner. It includes a memory adapted for storing a record of a number of iterative adjustments that are necessary to calibrate the gain of a photomultiplier detector block i at a time t.sub.0, a time t.sub.1 and a time T, where T>t.sub.1 >t.sub.0, which is designated as Histo(i,j(t)). The apparatus also includes a processor configured by a software program or a combination of programmed RAM and ROM devices to perform a number of calculations and operations on these values, and also includes a counter for analyzing each photomultiplier detector block i=1 through I of a PET scanner.

  20. Preventive maintenance system for the photomultiplier detector blocks of PET scanners

    DOE Patents [OSTI]

    Levy, A.V.; Warner, D.

    1995-01-24

    A system including a method and apparatus for preventive maintenance of PET scanner photomultiplier detector blocks is disclosed. The qualitative comparisons used in the method of the present invention to provide an indication in the form of a display or printout advising the user that the photomultiplier block is stable, intermittently unstable, or drifting unstable, and also advising of the expected date of failure of a photomultiplier block in the PET scanner. The system alerts the user to replace the defective photomultiplier block prior to catastrophic failure in a scheduled preventative maintenance program, thus eliminating expensive and unscheduled downtime of the PET scanner due to photomultiplier failure. The apparatus for carrying out the method of the present invention preferably resides in the host computer controlling a PET scanner. It includes a memory adapted for storing a record of a number of iterative adjustments that are necessary to calibrate the gain of a photomultiplier detector block i at a time t[sub 0], a time t[sub 1] and a time T, where T>t[sub 1]>t[sub 0], which is designated as Histo(i,j(t)). The apparatus also includes a processor configured by a software program or a combination of programmed RAM and ROM devices to perform a number of calculations and operations on these values, and also includes a counter for analyzing each photomultiplier detector block i=1 through I of a PET scanner. 40 figures.

  1. 0-6487-P1 / 5-6235-01-P1 USER'S GUIDE FOR PET: PROJECT EVALUATION

    E-Print Network [OSTI]

    Kockelman, Kara M.

    0-6487-P1 / 5-6235-01-P1 USER'S GUIDE FOR PET: PROJECT EVALUATION TOOLKIT Dr. Kara Kockelman Dan 5-6235: Implementation of Project Evaluation Toolkit for Abstracted Networks AUGUST 2012 Performing of Transportation and the Federal Highway Administration. #12;User's Guide for PET: Project Evaluation Toolkit

  2. Tumor delineation using PET in head and neck cancers: Threshold contouring and lesion volumes

    SciTech Connect (OSTI)

    Ford, Eric C.; Kinahan, Paul E.; Hanlon, Lorraine; Alessio, Adam; Rajendran, Joseph; Schwartz, David L.; Phillips, Mark [University of Washington, Department of Radiation Oncology, 1959 N. E. Pacific Street, Seattle, Washington 98195 (United States) and Puget Sound Veterans Administration, 18801 S. Columbian Way, Seattle, Washington 98195 (United States); University of Washington, Department of Radiology, 1959 N. E. Pacific Street, Seattle, Washington 98195 (United States); University of Washington, Department of Radiation Oncology, 1959 N. E. Pacific Street, Seattle, Washington 98195 and School of Physics, University College Dublin (Ireland); University of Washington, Department of Radiology, 1959 N. E. Pacific Street, Seattle, Washington 98195 (United States); University of Texas, M.D. Anderson Cancer Center, Department of Radiation Oncology, 1515 Holcombe Blvd., Houston, Texas 77030 and Puget Sound Veterans Administration, 1880 S. Columbian Way, Seattle, Washington 98195 (United States); University of Washington, Department of Radiation Oncology, 1959 N. E. Pacific Street, Seattle, Washington 98195 (United States)

    2006-11-15

    Tumor boundary delineation using positron emission tomography (PET) is a promising tool for radiation therapy applications. In this study we quantify the uncertainties in tumor boundary delineation as a function of the reconstruction method, smoothing, and lesion size in head and neck cancer patients using FDG-PET images and evaluate the dosimetric impact on radiotherapy plans. FDG-PET images were acquired for eight patients with a GE Advance PET scanner. In addition, a 20 cm diameter cylindrical phantom with six FDG-filled spheres with volumes of 1.2 to 26.5 cm{sup 3} was imaged. PET emission scans were reconstructed with the OSEM and FBP algorithms with different smoothing parameters. PET-based tumor regions were delineated using an automatic contouring function set at progressively higher threshold contour levels and the resulting volumes were calculated. CT-based tumor volumes were also contoured by a physician on coregistered PET/CT patient images. The intensity value of the threshold contour level that returns 100% of the actual volume, I{sub V100}, was measured. We generated intensity-modulated radiotherapy (IMRT) plans for an example head and neck patient, treating 66 Gy to CT-based gross disease and 54 Gy to nodal regions at risk, followed by a boost to the FDG-PET-based tumor. The volumes of PET-based tumors are a sensitive function of threshold contour level for all patients and phantom datasets. A 5% change in threshold contour level can translate into a 200% increase in volume. Phantom data indicate that I{sub V100} can be set as a fraction, f, of the maximum measured uptake. Fractional threshold values in the cylindrical water phantom range from 0.23 to 0.51. Both the fractional threshold and the threshold-volume curve are dependent on lesion size, with lesions smaller than approximately 5 cm{sup 3} displaying a more pronounced sensitivity and larger fractional threshold values. The threshold-volume curves and fractional threshold values also depend on the reconstruction algorithm and smoothing filter with more smoothing requiring a higher fractional threshold contour level. The threshold contour level affects the tumor size, and therefore the ultimate boost dose that is achievable with IMRT. In an example head and neck IMRT plan, the D95 of the planning target volume decreased from 7770 to 7230 cGy for 42% vs 55% contour threshold levels. PET-based tumor volumes are strongly affected by the choice of threshold level. This can have a significant dosimetric impact. The appropriate threshold level depends on lesion size and image reconstruction parameters. These effects should be carefully considered when using PET contour and/or volume information for radiotherapy applications.

  3. 4D PET Image Reconstruction from List Mode Data 1 Evren Asma, Thomas E. Nichols,

    E-Print Network [OSTI]

    Leahy, Richard M.

    functions that are based on assumptions about the physiological processes generating the data, e.g. blood4D PET Image Reconstruction from List Mode Data 1 Evren Asma, ¡ Thomas E. Nichols, ¢ Jinyi Qi, Richard M. Leahy£ Signal and Image Processing Institute, University of Southern California, Los Angeles

  4. Factors affecting degradation of polyethylene terephthalate (PET) during pre-flotation conditioning

    SciTech Connect (OSTI)

    Caparanga, Alvin R. Basilia, Blessie A.; Dagbay, Kevin B.; Salvacion, Jonathan W.L.

    2009-09-15

    In general, plastics are exposed to different degrading agents in every procedure involved in their recovery from waste mixture and from subsequent recycling. In this study, two methods of pre-flotation conditioning were used to determine how these methods affect the general properties of the pre-conditioned PET particles to be recovered from the PET-PVC mixture. The first method comprised the conditioning of PET samples using an alkaline solution of nonionic surfactant (Triton X-100) based on the patent by the Goodyear Tire and Rubber Company. The second method, developed in this study, was a conditioning process which used an alkali-less solution of the same nonionic surfactant (Triton X-100) used in the first method. The following analytical methods were used to characterize properties of the pre-conditioned PET samples that were correlated to relative degradation of the samples: differential scanning calorimetry (DSC), for thermal behavior of the samples; FT-IR spectroscopy, for functional groups present in the samples; and, Pohl's method, for carboxyl end-group concentration count. Results show that in addition to water the presence of NaOH in the conditioning solution contributes to the further degradation of the polymer.

  5. PET: A PErsonalized Trust Model with Reputation and Risk Evaluation for P2P Resource Sharing

    E-Print Network [OSTI]

    Shi, Weisong

    PET: A PErsonalized Trust Model with Reputation and Risk Evaluation for P2P Resource Sharing the construction of a good cooperation, especially in the context of economic-based solutions for the P2P resource sharing. The trust model consists of two parts: reputation evaluation and risk evaluation. Reputation

  6. FPGA-Based Data Acquisition System for a Positron Emission Tomography (PET) Scanner

    E-Print Network [OSTI]

    Hauck, Scott

    FPGA-Based Data Acquisition System for a Positron Emission Tomography (PET) Scanner Michael of performing complex discrete signal processing algorithms with clock rates of above 100MHz. This combined with FPGAs low expense, ease of use, and selected dedicated hardware make them an ideal technology for a data

  7. Comparison of first pass bolus AIFs extracted from sequential (^18)F-FDG PET and DSC-MRI of mice

    E-Print Network [OSTI]

    Evans, Eleanor; Sawiak, Stephen J.; Ward, Alexander O.; Buonincontri, Guido; Hawkes, Robert C.; Carpenter, T. Adrian

    2013-08-29

    tail vein 10s into a 100s single shot GE-EPI sequence (TR/TE 250/9ms, 71 spatial resolution 110×200?m2, 5 slices, thickness 1.5mm, 400 frames, 100s acq. time). The animal 72 bed was then transferred to the Focus 120 PET camera housed in the PET... thresholds. For the PET data, a volume of interest (VOI) for the left 109 ventricle was drawn on the final frame of each dataset using a manually seeded growth algorithm in 110 the ASIPro software provided with the scanner (Siemens Medical Solutions, USA...

  8. Tumor Response and Survival Predicted by Post-Therapy FDG-PET/CT in Anal Cancer

    SciTech Connect (OSTI)

    Schwarz, Julie K.; Siegel, Barry A.; Dehdashti, Farrokh; Myerson, Robert J.; Fleshman, James W.; Grigsby, Perry W.

    2008-05-01

    Purpose: To evaluate the response to therapy for anal carcinoma using post-therapy imaging with positron emission tomography (PET)/computed tomography and F-18 fluorodeoxyglucose (FDG) and to compare the metabolic response with patient outcome. Patients and Methods: This was a prospective cohort study of 53 consecutive patients with anal cancer. All patients underwent pre- and post-treatment whole-body FDG-PET/computed tomography. Patients had been treated with external beam radiotherapy and concurrent chemotherapy. Whole-body FDG-PET was performed 0.9-5.4 months (mean, 2.1) after therapy completion. Results: The post-therapy PET scan did not show any abnormal FDG uptake (complete metabolic response) in 44 patients. Persistent abnormal FDG uptake (partial metabolic response) was found in the anal tumor in 9 patients. The 2-year cause-specific survival rate was 94% for patients with a complete vs. 39% for patients with a partial metabolic response in the anal tumor (p = 0.0008). The 2-year progression-free survival rate was 95% for patients with a complete vs. 22% for patients with a partial metabolic response in the anal tumor (p < 0.0001). A Cox proportional hazards model of survival outcome indicated that a complete metabolic response was the most significant predictor of progression-free survival in our patient population (p = 0.0003). Conclusions: A partial metabolic response in the anal tumor as determined by post-therapy FDG-PET is predictive of significantly decreased progression-free and cause-specific survival after chemoradiotherapy for anal cancer.

  9. Fabrication and characterization of a 0.5-mm lutetium oxyorthosilicate detector array for high-resolution PET applications

    E-Print Network [OSTI]

    Stickel, Jennifer R; Qi, Jinyi; Cherry, Simon R

    2007-01-01

    2006;51:2131–2142. 0.5- MM LSO A RRAY FOR PET • Stickel etand Characterization of a 0.5-mm Lutetium Oxyorthosilicatelicate (LSO) arrays with 0.5-mm pixels was coupled to

  10. Evaluating the purity of a {sup 57}Co flood source by PET

    SciTech Connect (OSTI)

    DiFilippo, Frank P., E-mail: difilif@ccf.org [Department of Nuclear Medicine, Cleveland Clinic, Cleveland, Ohio 44195 (United States)

    2014-11-01

    Purpose: Flood sources of {sup 57}Co are commonly used for quality control of gamma cameras. Flood uniformity may be affected by the contaminants {sup 56}Co and {sup 58}Co, which emit higher energy photons. Although vendors specify a maximum combined {sup 56}Co and {sup 58}Co activity, a convenient test for flood source purity that is feasible in a clinical environment would be desirable. Methods: Both {sup 56}Co and {sup 58}Co emit positrons with branching 19.6% and 14.9%, respectively. As is known from {sup 90}Y imaging, a positron emission tomography (PET) scanner is capable of quantitatively imaging very weak positron emission in a high single-photon background. To evaluate this approach, two {sup 57}Co flood sources were scanned with a clinical PET/CT multiple times over a period of months. The {sup 56}Co and {sup 58}Co activity was clearly visible in the reconstructed PET images. Total impurity activity was quantified from the PET images after background subtraction of prompt gamma coincidences. Results: Time-of-flight PET reconstruction was highly beneficial for accurate image quantification. Repeated measurements of the positron-emitting impurities showed excellent agreement with an exponential decay model. For both flood sources studied, the fit parameters indicated a zero intercept and a decay half-life consistent with a mixture of {sup 56}Co and {sup 58}Co. The total impurity activity at the reference date was estimated to be 0.06% and 0.07% for the two sources, which was consistent with the vendor’s specification of <0.12%. Conclusions: The robustness of the repeated measurements and a thorough analysis of the detector corrections and physics suggest that the accuracy is acceptable and that the technique is feasible. Further work is needed to validate the accuracy of this technique with a calibrated high resolution gamma spectrometer as a gold standard, which was not available for this study, and for other PET detector models.

  11. A systematic investigation of PET Radionuclide Specific Activity on Miniaturization of Radiochemistry

    SciTech Connect (OSTI)

    Jeanne M Link, PhD

    2012-03-08

    The PET radionuclides, 18F and 11C consist of very high radiation to mass amounts and should be easily adapted to new technologies such as �chip chemistry� with nanofluidics. However, environmental contamination with nonradioactive fluorine, carbon and other trace contaminants add sufficient mass, micrograms to milligrams, to prevent adapting PET radiochemistry to the nanochip technologies. In addition, the large volumes of material required for beam irradiation make it necessary to also remove the 18F and 11C from their chemical matrices. These steps add contaminants. The work described in this report was a systematic investigation of sources of these contaminants and methods to reduce these contaminants and the reaction volumes for radiochemical synthesis. Several methods were found to lower the contaminants and matrices to within a factor of 2 to 100 of those needed to fully implement chip technology but further improvements are needed.

  12. Application of WLS strips for position determination in Strip PET tomograph based on plastic scintillators

    E-Print Network [OSTI]

    Smyrski, J; Bednarski, T; Bia?as, P; Czerwi?ski, E; Kap?on, ?; Kochanowski, A; Korcyl, G; Kowal, J; Kowalski, P; Kozik, T; Krzemie?, W; Molenda, M; Nied?wiecki, Sz; Pa?ka, M; Pawlik, M; Raczy?ski, L; Rudy, Z; Salabura, P; Sharma, N G; Silarski, M; S?omski, A; Strzelecki, A; Wi?licki, W; Zieli?ski, M; Zo?, N

    2013-01-01

    A method of determination of a gamma quantum absorption point in a plastic scintillator block using a matrix of wavelength-shifting (WLS) strips is proposed. Application of this method for improvement of position resolution in newly proposed PET detectors based on plastic scintillators is presented. The method enables to reduce parallax errors in reconstruction of images which occurs in the presently used Positron Emission Tomography scanners.

  13. Application of WLS strips for position determination in Strip PET tomograph based on plastic scintillators

    E-Print Network [OSTI]

    J. Smyrski; P. Moskal; T. Bednarski; P. Bia?as; E. Czerwi?ski; ?. Kap?on; A. Kochanowski; G. Korcyl; J. Kowal; P. Kowalski; T. Kozik; W. Krzemie?; M. Molenda; Sz. Nied?wiecki; M. Pa?ka; M. Pawlik; L. Raczy?ski; Z. Rudy; P. Salabura; N. G. Sharma; M. Silarski; A. S?omski; A. Strzelecki; W. Wi?licki; M. Zieli?ski; N. Zo?

    2013-11-24

    A method of determination of a gamma quantum absorption point in a plastic scintillator block using a matrix of wavelength-shifting (WLS) strips is proposed. Application of this method for improvement of position resolution in newly proposed PET detectors based on plastic scintillators is presented. The method enables to reduce parallax errors in reconstruction of images which occurs in the presently used Positron Emission Tomography scanners.

  14. Microfluidics without channels: highly-flexible synthesis on a digital-microfluidic chip for production of diverse PET tracers

    SciTech Connect (OSTI)

    Van Dam, Robert Michael [Univ. of California, Los Angeles, CA (United States)

    2010-09-01

    Positron emission tomography (PET) imaging is used for fundamental studies of living biological organisms and microbial ecosystems in applications ranging from biofuel production to environmental remediation to the study, diagnosis, and treatment monitoring of human disease. Routine access to PET imaging, to monitor biochemical reactions in living organisms in real time, could accelerate a broad range of research programs of interest to DOE. Using PET requires access to short-lived radioactive-labeled compounds that specifically probe the desired living processes. The overall aims of this project were to develop a miniature liquid-handling technology platform (called “microfluidics”) that increases the availability of diverse PET probes by reducing the cost and complexity of their production. Based on preliminary experiments showing that microfluidic chips can synthesis such compounds, we aimed to advance this technology to improve its robustness, increase its flexibility for a broad range of probes, and increase its user-friendliness. Through the research activities of this project, numerous advances were made; Tools were developed to enable the visualization of radioactive materials within microfluidic chips; Fundamental advances were made in the microfluidic chip architecture and fabrication process to increase its robustness and reliability; The microfluidic chip technology was shown to produce useful quantities of an example PET probes, and methods to further increase the output were successfully pursued; A “universal” chip was developed that could produce multiple types of PET probes, enabling the possibility of “on demand” synthesis of different probes; and Operation of the chip was automated to ensure minimal radiation exposure to the operator Based on the demonstrations of promising technical feasibility and performance, the microfluidic chip technology is currently being commercialized. It is anticipated that costs of microfluidic chips can be dramatically reduced in the future by leveraging economies of scale in the microelectronics industry, leading to low cost production of PET probes.

  15. Longitudinal, intermodality registration of quantitative breast PET and MRI data acquired before and during neoadjuvant chemotherapy: Preliminary results

    SciTech Connect (OSTI)

    Atuegwu, Nkiruka C.; Williams, Jason M.; Li, Xia; Arlinghaus, Lori R.; Abramson, Richard G.; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2675; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232-6838 ; Chakravarthy, A. Bapsi; Abramson, Vandana G.; Yankeelov, Thomas E.

    2014-05-15

    Purpose: The authors propose a method whereby serially acquired DCE-MRI, DW-MRI, and FDG-PET breast data sets can be spatially and temporally coregistered to enable the comparison of changes in parameter maps at the voxel level. Methods: First, the authors aligned the PET and MR images at each time point rigidly and nonrigidly. To register the MR images longitudinally, the authors extended a nonrigid registration algorithm by including a tumor volume-preserving constraint in the cost function. After the PET images were aligned to the MR images at each time point, the authors then used the transformation obtained from the longitudinal registration of the MRI volumes to register the PET images longitudinally. The authors tested this approach on ten breast cancer patients by calculating a modified Dice similarity of tumor size between the PET and MR images as well as the bending energy and changes in the tumor volume after the application of the registration algorithm. Results: The median of the modified Dice in the registered PET and DCE-MRI data was 0.92. For the longitudinal registration, the median tumor volume change was ?0.03% for the constrained algorithm, compared to ?32.16% for the unconstrained registration algorithms (p = 8 × 10{sup ?6}). The medians of the bending energy were 0.0092 and 0.0001 for the unconstrained and constrained algorithms, respectively (p = 2.84 × 10{sup ?7}). Conclusions: The results indicate that the proposed method can accurately spatially align DCE-MRI, DW-MRI, and FDG-PET breast images acquired at different time points during therapy while preventing the tumor from being substantially distorted or compressed.

  16. Application of the Compress Sensing Theory for Improvement of the TOF Resolution in a Novel J-PET Instrument

    E-Print Network [OSTI]

    L. Raczynski; P. Moskal; P. Kowalski; W. Wislicki; T. Bednarski; P. Bialas; E. Czerwinski; A. Gajos; L. Kaplon; A. Kochanowski; G. Korcyl; J. Kowal; T. Kozik; W. Krzemien; E. Kubicz; Sz. Niedzwiecki; M. Palka; Z. Rudy; P. Salabura; N. G. Sharma; M. Silarski; A. Slomski; J. Smyrski; A. Strzelecki; A. Wieczorek; M. Zielinski; N. Zon

    2015-08-08

    Nowadays, in Positron Emission Tomography (PET) systems, a Time of Flight information is used to improve the image reconstruction process. In Time of Flight PET (TOF-PET), fast detectors are able to measure the di?erence in the arrival time of the two gamma rays, with the precision enabling to shorten signi?cantly a range along the line-of-response (LOR) where the annihilation occurred. In the new concept, called J-PET scanner, gamma rays are detected in plastic scintillators. In a single strip of J-PET system, time values are obtained by probing signals in the amplitude domain. Owing to Compress Sensing theory, information about the shape and amplitude of the signals is recovered. In this paper we demonstrate that based on the acquired signals parameters, a better signal normalization may be provided in order to improve the TOF resolution. The procedure was tested using large sample of data registered by a dedicated detection setup enabling sampling of signals with 50 ps intervals. Experimental setup provided irradiation of a chosen position in the plastic scintillator strip with annihilation gamma quanta.

  17. Application of the Compress Sensing Theory for Improvement of the TOF Resolution in a Novel J-PET Instrument

    E-Print Network [OSTI]

    Raczynski, L; Kowalski, P; Wislicki, W; Bednarski, T; Bialas, P; Czerwinski, E; Gajos, A; Kaplon, L; Kochanowski, A; Korcyl, G; Kowal, J; Kozik, T; Krzemien, W; Kubicz, E; Niedzwiecki, Sz; Palka, M; Rudy, Z; Salabura, P; Sharma, N G; Silarski, M; Slomski, A; Smyrski, J; Strzelecki, A; Wieczorek, A; Zielinski, M; Zon, N

    2015-01-01

    Nowadays, in Positron Emission Tomography (PET) systems, a Time of Flight information is used to improve the image reconstruction process. In Time of Flight PET (TOF-PET), fast detectors are able to measure the di?erence in the arrival time of the two gamma rays, with the precision enabling to shorten signi?cantly a range along the line-of-response (LOR) where the annihilation occurred. In the new concept, called J-PET scanner, gamma rays are detected in plastic scintillators. In a single strip of J-PET system, time values are obtained by probing signals in the amplitude domain. Owing to Compress Sensing theory, information about the shape and amplitude of the signals is recovered. In this paper we demonstrate that based on the acquired signals parameters, a better signal normalization may be provided in order to improve the TOF resolution. The procedure was tested using large sample of data registered by a dedicated detection setup enabling sampling of signals with 50 ps intervals. Experimental setup provide...

  18. Medical Imaging Process Accelerated in FPGA Hardware by 82x over Software Line of Reaction Estimation for a PET scanner Optimized using C to FPGA Methodology

    E-Print Network [OSTI]

    Hauck, Scott

    for a high-resolution Positron Emission Tomography (PET) scanner. The estimation algorithm provides Estimation for a PET scanner Optimized using C to FPGA Methodology Zhongho Chen Department of CSIE, National to the exact needs of a given computation. In previous work we have benchmarked a CT scanner backprojection

  19. Cleaning Supplies Manufacturer/Supplier Gen Peds GI ETC US CT MRI BI Ortho FCC Angio PET A33 Dry Airkem X

    E-Print Network [OSTI]

    Cleaning Supplies Manufacturer/Supplier Gen Peds GI ETC US CT MRI BI Ortho FCC Angio PET NUC MED A\\MSDS.xls #12;Cleaning Supplies Manufacturer/Supplier Gen Peds GI ETC US CT MRI BI Ortho FCC Angio PET NUC MED

  20. Improved UTE-based attenuation correction for cranial PET-MR using dynamic magnetic field monitoring

    SciTech Connect (OSTI)

    Aitken, A. P.; Giese, D.; Tsoumpas, C.; Schleyer, P.; Kozerke, S.; Prieto, C.; Schaeffter, T., E-mail: Tobias.Schaeffter@kcl.ac.uk [Department of Biomedical Engineering, Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas Hospital, London SE1 7EH (United Kingdom)

    2014-01-15

    Purpose: Ultrashort echo time (UTE) MRI has been proposed as a way to produce segmented attenuation maps for PET, as it provides contrast between bone, air, and soft tissue. However, UTE sequences require samples to be acquired during rapidly changing gradient fields, which makes the resulting images prone to eddy current artifacts. In this work it is demonstrated that this can lead to misclassification of tissues in segmented attenuation maps (AC maps) and that these effects can be corrected for by measuring the true k-space trajectories using a magnetic field camera. Methods: The k-space trajectories during a dual echo UTE sequence were measured using a dynamic magnetic field camera. UTE images were reconstructed using nominal trajectories and again using the measured trajectories. A numerical phantom was used to demonstrate the effect of reconstructing with incorrect trajectories. Images of an ovine leg phantom were reconstructed and segmented and the resulting attenuation maps were compared to a segmented map derived from a CT scan of the same phantom, using the Dice similarity measure. The feasibility of the proposed method was demonstrated inin vivo cranial imaging in five healthy volunteers. Simulated PET data were generated for one volunteer to show the impact of misclassifications on the PET reconstruction. Results: Images of the numerical phantom exhibited blurring and edge artifacts on the bone–tissue and air–tissue interfaces when nominal k-space trajectories were used, leading to misclassification of soft tissue as bone and misclassification of bone as air. Images of the tissue phantom and thein vivo cranial images exhibited the same artifacts. The artifacts were greatly reduced when the measured trajectories were used. For the tissue phantom, the Dice coefficient for bone in MR relative to CT was 0.616 using the nominal trajectories and 0.814 using the measured trajectories. The Dice coefficients for soft tissue were 0.933 and 0.934 for the nominal and measured cases, respectively. For air the corresponding figures were 0.991 and 0.993. Compared to an unattenuated reference image, the mean error in simulated PET uptake in the brain was 9.16% when AC maps derived from nominal trajectories was used, with errors in the SUV{sub max} for simulated lesions in the range of 7.17%–12.19%. Corresponding figures when AC maps derived from measured trajectories were used were 0.34% (mean error) and ?0.21% to +1.81% (lesions). Conclusions: Eddy current artifacts in UTE imaging can be corrected for by measuring the true k-space trajectories during a calibration scan and using them in subsequent image reconstructions. This improves the accuracy of segmented PET attenuation maps derived from UTE sequences and subsequent PET reconstruction.

  1. Compartment modeling of dynamic brain PET—The impact of scatter corrections on parameter errors

    SciTech Connect (OSTI)

    Häggström, Ida Karlsson, Mikael; Larsson, Anne; Schmidtlein, C. Ross

    2014-11-01

    Purpose: The aim of this study was to investigate the effect of scatter and its correction on kinetic parameters in dynamic brain positron emission tomography (PET) tumor imaging. The 2-tissue compartment model was used, and two different reconstruction methods and two scatter correction (SC) schemes were investigated. Methods: The GATE Monte Carlo (MC) software was used to perform 2 × 15 full PET scan simulations of a voxelized head phantom with inserted tumor regions. The two sets of kinetic parameters of all tissues were chosen to represent the 2-tissue compartment model for the tracer 3?-deoxy-3?-({sup 18}F)fluorothymidine (FLT), and were denoted FLT{sub 1} and FLT{sub 2}. PET data were reconstructed with both 3D filtered back-projection with reprojection (3DRP) and 3D ordered-subset expectation maximization (OSEM). Images including true coincidences with attenuation correction (AC) and true+scattered coincidences with AC and with and without one of two applied SC schemes were reconstructed. Kinetic parameters were estimated by weighted nonlinear least squares fitting of image derived time–activity curves. Calculated parameters were compared to the true input to the MC simulations. Results: The relative parameter biases for scatter-eliminated data were 15%, 16%, 4%, 30%, 9%, and 7% (FLT{sub 1}) and 13%, 6%, 1%, 46%, 12%, and 8% (FLT{sub 2}) for K{sub 1}, k{sub 2}, k{sub 3}, k{sub 4}, V{sub a}, and K{sub i}, respectively. As expected, SC was essential for most parameters since omitting it increased biases by 10 percentage points on average. SC was not found necessary for the estimation of K{sub i} and k{sub 3}, however. There was no significant difference in parameter biases between the two investigated SC schemes or from parameter biases from scatter-eliminated PET data. Furthermore, neither 3DRP nor OSEM yielded the smallest parameter biases consistently although there was a slight favor for 3DRP which produced less biased k{sub 3} and K{sub i} estimates while OSEM resulted in a less biased V{sub a}. The uncertainty in OSEM parameters was about 26% (FLT{sub 1}) and 12% (FLT{sub 2}) larger than for 3DRP although identical postfilters were applied. Conclusions: SC was important for good parameter estimations. Both investigated SC schemes performed equally well on average and properly corrected for the scattered radiation, without introducing further bias. Furthermore, 3DRP was slightly favorable over OSEM in terms of kinetic parameter biases and SDs.

  2. Resources for Pet, Poultry and Livestock Owners Affected by Natural Disasters 

    E-Print Network [OSTI]

    Faries Jr., Floron C.

    2008-09-02

    of Agriculture can help producers locate hay for sale and pastures for lease. Call 877-429- 1998, or go to www.agr.state.tx.us and check the ?Links/Resources? sec- tion. Resources for Pet, Poultry and Livestock Owners Affected by Natural Disasters Livestock... stream_source_info pdf_2228.pdf.txt stream_content_type text/plain stream_size 3611 Content-Encoding ISO-8859-1 stream_name pdf_2228.pdf.txt Content-Type text/plain; charset=ISO-8859-1 ER-022 9-08 Floron C. Faries, Jr...

  3. Macrocyclic polyaminocarboxylates for stable radiometal antibody conjugates for therapy, SPECT and PET imaging

    DOE Patents [OSTI]

    Mease, R.C.; Mausner, L.F.; Srivastava, S.C.

    1997-06-17

    A simple method for the synthesis of 1,4,7, 10-tetraazacyclododecane N,N{prime}N{double_prime},N{prime}{double_prime}-tetraacetic acid and 1,4,8,11-tetraazacyclotetradecane N,N{prime},N{double_prime},N{prime}{double_prime}-tetraacetic acid involves cyanomethylating 1,4,7,10-tetraazacyclododecane or 1,4,8,11-tetraazacyclotetradecane to form a tetranitrile and hydrolyzing the tetranitrile. These macrocyclic compounds are functionalized through one of the carboxylates and then conjugated to various biological molecules including monoclonal antibodies. The resulting conjugated molecules are labeled with radiometals for SPECT and PET imaging and for radiotherapy. 4 figs.

  4. Nuclear Instruments and Methods in Physics Research A 545 (2005) 427435 CYBPET: a cylindrical PET system for breast imaging

    E-Print Network [OSTI]

    Thompson, Chris

    2005-01-01

    Nuclear Instruments and Methods in Physics Research A 545 (2005) 427­435 CYBPET: a cylindrical PET. Davilua , D. Sardaria a Amirkabir University of Technology, Tehran, Iran b Nuclear Research CenterGill University, Montreal QC, Canada e Medical physics Department of Tehran University of Medical Sciences

  5. Flexible dye-sensitized solar cells with ZnO nanoparticles grown by Sonochemistry over Graphene/PET substrates.

    E-Print Network [OSTI]

    Pala, Nezih

    Flexible dye-sensitized solar cells with ZnO nanoparticles grown by Sonochemistry over Graphene characteristics of ZnO nanostructures over Graphene/PET as photoanode for flexible dye sensitized solar cells. #12; and Engineering University of North Texas, Denton, Texas Flexible Dye sensitized solar cells (FDSSCs) are light

  6. Effect of 200 keV Ar{sup +} implantation on optical and electrical properties of polyethyleneterepthalate (PET)

    SciTech Connect (OSTI)

    Kumar, Rajiv Goyal, Meetika Sharma, Ambika; Aggarwal, Sanjeev; Sharma, Annu; Kanjilal, D.

    2015-05-15

    In the present paper we have discussed the effect of 200 keV Ar{sup +} ions on the electrical and optical properties of PET samples. PET samples were implanted with 200 keV Ar{sup +} ions to various doses ranging from 1×10{sup 15} to 1×10{sup 17} Ar{sup +} cm{sup 2}. The changes in the electrical and optical properties of pristine and implanted PET specimens have been studied by using Keithley electrometer and UV-Visible absorption spectroscopy. The electrical conductivity has found to be increased with increasing ion dose. The optical studies have revealed the drastic alterations in optical band gap from 3.63 eV to 1.48 eV and also increase in number of carbon atoms per cluster from 215 to 537. Further, the change in the electrical conductivity and optical band gap has also been correlated with the formation of conductive islands in the implanted layers of PET.

  7. Comparison of an alternative and existing binning methods to reduce the acquisition duration of 4D PET/CT

    SciTech Connect (OSTI)

    Didierlaurent, David, E-mail: dadidierlaurent@gmail.com; Ribes, Sophie; Caselles, Olivier [SIMAD, LU 50, Université Toulouse III Paul Sabatier, Toulouse 31062 (France); Jaudet, Cyril; Dierickx, Lawrence O.; Zerdoud, Slimane; Brillouet, Severine; Weits, Kathleen [Institut Claudius Regaud, 20-24 Rue du Pont Saint-Pierre, Toulouse 31052 (France); Batatia, Hadj [IRIT-INPT, Université Toulouse III Paul Sabatier, Toulouse 31071 (France); Courbon, Frédéric [GCS CHU-CLCC, Université Toulouse III Paul Sabatier, Toulouse 31052 (France)

    2014-11-01

    Purpose: Respiratory motion is a source of artifacts that reduce image quality in PET. Four dimensional (4D) PET/CT is one approach to overcome this problem. Existing techniques to limiting the effects of respiratory motions are based on prospective phase binning which requires a long acquisition duration (15–25 min). This time is uncomfortable for the patients and limits the clinical exploitation of 4D PET/CT. In this work, the authors evaluated an existing method and an alternative retrospective binning method to reduce the acquisition duration of 4D PET/CT. Methods: The authors studied an existing mixed-amplitude binning (MAB) method and an alternative binning method by mixed-phases (MPhB). Before implementing MPhB, they analyzed the regularity of the breathing patterns in patients. They studied the breathing signal drift and missing CT slices that could be challenging for implementing MAB. They compared the performance of MAB and MPhB with current binning methods to measure the maximum uptake, internal volume, and maximal range of tumor motion. Results: MPhB can be implemented depending on an optimal phase (in average, the exhalation peak phase ?4.1% of the entire breathing cycle duration). Signal drift of patients was in average 35% relative to the breathing amplitude. Even after correcting this drift, MAB was feasible in 4D CT for only 64% of patients. No significant differences appeared between the different binning methods to measure the maximum uptake, internal volume, and maximal range of tumor motion. The authors also determined the inaccuracies of MAB and MPhB to measure the maximum amplitude of tumor motion with three bins (less than 3 mm for movement inferior to 12 mm, up to 6.4 mm for a 21 mm movement). Conclusions: The authors proposed an alternative binning method by mixed-phase binning that halves the acquisition duration of 4D PET/CT. Mixed-amplitude binning was challenging because of signal drift and missing CT slices. They showed that more than three bins were necessary for a more accurate measurement of the maximum amplitude of the tumor motion. However, the current 4D-CT technology limits the increase of the number of bins in 4D PET/CT because of missing CT slices. One can reconstruct 4D PET images with more bins but without attenuation/scatter correction.

  8. Compressive Sensing of Signals Generated in Plastic Scintillators in a Novel J-PET Instrument

    E-Print Network [OSTI]

    Raczynski, L; Kowalski, P; Wislicki, W; Bednarski, T; Bialas, P; Czerwinski, E; Gajos, A; Kaplon, L; Kochanowski, A; Korcyl, G; Kowal, J; Kozik, T; Krzemien, W; Kubicz, E; Niedzwiecki, Sz; Palka, M; Rudy, Z; Rundel, O; Salabura, P; Sharma, N G; Silarski, M; lomski, A S; Smyrski, J; Strzelecki, A; Wieczorek, A; Zielinski, M; Zon, N

    2015-01-01

    The J-PET scanner, which allows for single bed imaging of the whole human body, is currently under development at the Jagiellonian University. The dis- cussed detector offers improvement of the Time of Flight (TOF) resolution due to the use of fast plastic scintillators and dedicated electronics allowing for sam- pling in the voltage domain of signals with durations of few nanoseconds. In this paper we show that recovery of the whole signal, based on only a few samples, is possible. In order to do that, we incorporate the training signals into the Tikhonov regularization framework and we perform the Principal Component Analysis decomposition, which is well known for its compaction properties. The method yields a simple closed form analytical solution that does not require iter- ative processing. Moreover, from the Bayes theory the properties of regularized solution, especially its covariance matrix, may be easily derived. This is the key to introduce and prove the formula for calculations of the signal recove...

  9. Cholecystokinin-Assisted Hydrodissection of the Gallbladder Fossa during FDG PET/CT-guided Liver Ablation

    SciTech Connect (OSTI)

    Tewari, Sanjit O.; Petre, Elena N.; Osborne, Joseph; Sofocleous, Constantinos T.

    2013-12-15

    A 68-year-old female with colorectal cancer developed a metachronous isolated fluorodeoxyglucose-avid (FDG-avid) segment 5/6 gallbladder fossa hepatic lesion and was referred for percutaneous ablation. Pre-procedure computed tomography (CT) images demonstrated a distended gallbladder abutting the segment 5/6 hepatic metastasis. In order to perform ablation with clear margins and avoid direct puncture and aspiration of the gallbladder, cholecystokinin was administered intravenously to stimulate gallbladder contraction before hydrodissection. Subsequently, the lesion was ablated successfully with sufficient margins, of greater than 1.0 cm, using microwave with ultrasound and FDG PET/CT guidance. The patient tolerated the procedure very well and was discharged home the next day.

  10. Active barrier films of PET for solar cell application: Processing and characterization

    SciTech Connect (OSTI)

    Rossi, Gabriella; Scarfato, Paola; Incarnato, Loredana [Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II, 132 - 84084 Fisciano (Italy)

    2014-05-15

    A preliminary investigation was carried out on the possibility to improve the protective action offered by the standard multilayer structures used to encapsulate photovoltaic devices. With this aim, a commercial active barrier PET-based material, able to absorb oxygen when activated by liquid water, was used to produce flexible and transparent active barrier films, by means of a lab-scale film production plant. The obtained film, tested in terms of thermal, optical and oxygen absorption properties, shows a slow oxygen absorption kinetics, an acceptable transparency and an easy roll-to-roll processability, so proving itself as a good candidate for the development of protective coating for solar cells against the atmospheric degradation agents like the rain.

  11. High density polyethylene (HDPE) containers as an alternative to polyethylene terephthalate (PET) bottles for solar disinfection of drinking water in northern region, Ghana

    E-Print Network [OSTI]

    Yazdani, Iman

    2007-01-01

    The purpose of this study is to investigate the technical feasibility of high density polyethylene (HDPE) containers as an alternative to polyethylene terephthalate (PET) bottles for the solar disinfection of drinking water ...

  12. Correction for FDG PET dose extravasations: Monte Carlo validation and quantitative evaluation of patient studies

    SciTech Connect (OSTI)

    Silva-Rodríguez, Jesús Aguiar, Pablo; Servicio de Medicina Nuclear, Complexo Hospitalario Universidade de Santiago de Compostela , 15782, Galicia; Grupo de Imaxe Molecular, Instituto de Investigación Sanitarias , Santiago de Compostela, 15706, Galicia ; Sánchez, Manuel; Mosquera, Javier; Luna-Vega, Víctor; Cortés, Julia; Garrido, Miguel; Pombar, Miguel; Ruibal, Álvaro; Grupo de Imaxe Molecular, Instituto de Investigación Sanitarias , Santiago de Compostela, 15706, Galicia; Fundación Tejerina, 28003, Madrid

    2014-05-15

    Purpose: Current procedure guidelines for whole body [18F]fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography (PET) state that studies with visible dose extravasations should be rejected for quantification protocols. Our work is focused on the development and validation of methods for estimating extravasated doses in order to correct standard uptake value (SUV) values for this effect in clinical routine. Methods: One thousand three hundred sixty-seven consecutive whole body FDG-PET studies were visually inspected looking for extravasation cases. Two methods for estimating the extravasated dose were proposed and validated in different scenarios using Monte Carlo simulations. All visible extravasations were retrospectively evaluated using a manual ROI based method. In addition, the 50 patients with higher extravasated doses were also evaluated using a threshold-based method. Results: Simulation studies showed that the proposed methods for estimating extravasated doses allow us to compensate the impact of extravasations on SUV values with an error below 5%. The quantitative evaluation of patient studies revealed that paravenous injection is a relatively frequent effect (18%) with a small fraction of patients presenting considerable extravasations ranging from 1% to a maximum of 22% of the injected dose. A criterion based on the extravasated volume and maximum concentration was established in order to identify this fraction of patients that might be corrected for paravenous injection effect. Conclusions: The authors propose the use of a manual ROI based method for estimating the effectively administered FDG dose and then correct SUV quantification in those patients fulfilling the proposed criterion.

  13. Radiofrequency Ablation of Non-Small-Cell Carcinoma of the Lung Under Real-Time FDG PET CT Guidance

    SciTech Connect (OSTI)

    Schoellnast, Helmut; Larson, Steven M. [Memorial Sloan-Kettering Cancer Center, Department of Radiology (United States); Nehmeh, Sadek A. [Memorial Sloan-Kettering Cancer Center, Department of Medical Physics (United States); Carrasquillo, Jorge A.; Thornton, Raymond H.; Solomon, Stephen B., E-mail: solomons@mskcc.org [Memorial Sloan-Kettering Cancer Center, Department of Radiology (United States)

    2011-02-15

    Radiofrequency ablation (RFA) is a well-established method in treatment of patients with lung carcinomas who are not candidates for surgical resection. Usually computed tomographic (CT) guidance is used for the procedure, thus enabling needle placement and permitting evaluation of complications such as pneumothorax and bleeding. {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is generally used for tumor activity assessment and is therefore useful in follow-up after tumor treatment. A method that provides real-time image-based monitoring of RFA to ensure complete tumor ablation would be a valuable tool. In this report, we describe the behavior of preinjected FDG during PET CT-guided RFA of a non-small-cell lung carcinoma and discuss the value of FDG as a tool to provide intraprocedure monitor ablation. The size and the form of the activity changed during ablation. Ablation led to increase of the size and blurring and irregularity of the contour compared to pretreatment imaging. The maximal standardized uptake value decreased only slightly during the procedure. Therefore, before RFA, FDG PET can guide initial needle placement, but it does not serve as a monitoring tool to evaluate residual viable tissue during the procedure.

  14. Evaluation of the Dopamine Hypothesis of ADHD with PET Brain Imaging

    ScienceCinema (OSTI)

    Swanson, James [University of California, Irvine, California, United States

    2010-09-01

    The Dopamine (DA) Hypothesis of ADHD (Wender, 1971; Levy, 1990) suggests that abnormalities in the synaptic mechanisms of DA transmission may be disrupted, and specific abnormalities in DA receptors and DA transporters (DAT) have been proposed (see Swanson et al, 1998). Early studies with small samples (e.g., n = 6, Dougherty et al, 1999) used single photon emission tomography (SPECT) and the radioligand (123I Altropane) to test a theory that ADHD may be caused by an over expression of DAT and reported 'a 70% increase in age-corrected dopamine transporter density in patients with attention deficit hyperactivity disorder compared with healthy controls' and suggested that treatment with stimulant medication decreased DAT density in ADHD patients and corrected an underlying abnormality (Krause et al, 2000). The potential importance of these findings was noted by Swanson (1999): 'If true, this is a major finding and points the way for new investigations of the primary pharmacological treatment for ADHD (with the stimulant drugs - e.g., methylphenidate), for which the dopamine transporter is the primary site of action. The potential importance of this finding demands special scrutiny'. This has been provided over the past decade using Positron Emission Tomography (PET). Brain imaging studies were conducted at Brookhaven National Laboratory (BNL) in a relatively large sample of stimulant-naive adults assessed for DAT (11C cocaine) density and DA receptors (11C raclopride) availability. These studies (Volkow et al, 2007; Volkow et al, 2009) do not confirm the hypothesis of increased DAT density and suggest the opposite (i.e., decreased rather than increased DAT density), and follow-up after treatment (Wang et al, 2010) does not confirm the hypothesis that therapeutic doses of methylphenidate decrease DAT density and suggests the opposite (i.e., increased rather than decreased DAT density). The brain regions implicated by these PET imaging studies also suggest that a motivation deficit may contribute as much as an attention deficit to the manifestation of behaviors that underlie the symptoms of ADHD.

  15. Aromatase imaging with [N-methyl-C-11]vorozole PET in healthy men and women

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Biegon, Anat [Stony Brook Univ., NY (United States). School of Medicine; Brookhaven National Lab. (BNL), Upton, NY (United States); Fowler, Joanna S. [Brookhaven National Lab. (BNL), Upton, NY (United States); State University of New York, Stony Brook, NY (United States); Alexoff, David L. [Brookhaven National Lab. (BNL), Upton, NY (United States); Kim, Sung Won [National Institute on Alcoholism and Alcohol Abuse, Bethesda, MD (United States); Logan, Jean [New York University Langone Medical Center, New York, NY (United States); Pareto, Deborah [Institut de Recerca Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Alta Tecnologia, Barcelona (Spain); Schlyer, David [Brookhaven National Lab. (BNL), Upton, NY (United States); Wang, Gene-Jack [National Institute on Alcoholism and Alcohol Abuse, Bethesda, MD (United States)

    2015-04-01

    Aromatase, the last and obligatory enzyme catalyzing estrogen biosynthesis from androgenic precursors, can be labeled in vivo with ¹¹C-vorozole. Aromatase inhibitors are widely used in breast cancer and other endocrine conditions. The present study aims to provide baseline information defining aromatase distribution in healthy men and women, against which its perturbation in pathological situations can be studied. Methods: ¹¹C-vorozole (111-296 MBq/subject) was injected I.V in 13 men and 20 women (age range 23 to 67). PET data were acquired over a 90 minute period. Each subject had 4 scans, 2/day separated by 2-6 weeks, including brain and torso or pelvis scans. Young women were scanned at 2 discrete phases of the menstrual cycle (midcycle and late luteal). Men and postmenopausal women were also scanned following pretreatment with a clinical dose of the aromatase inhibitor letrozole (“blocking” studies). Time activity curves were obtained and standard uptake values (SUV) calculated for major organs including brain, heart, lungs, liver, kidneys, spleen, muscle, bone and male and female reproductive organs (penis, testes, uterus, ovaries). Organ and whole body radiation exposures were calculated using Olinda software. Results: Liver uptake was higher than all other organs, but was not blocked by pretreatment with letrozole. Mean SUVs in men were higher than in women, and brain uptake was blocked by letrozole. Male brain SUVs were also higher than all other organs (ranging from 0.48±0.05 in lungs to 1.5±0.13 in kidneys). Mean ovarian SUVs (3.08±0.7) were comparable to brain levels and higher than all other organs. Furthermore, ovarian SUVs In young women around the time of ovulation (midcycle) were significantly higher than those measured in the late luteal phase, while aging and cigarette smoking reduced ¹¹C-vorozole uptake. Conclusions: PET with ¹¹C-vorozole is useful for assessing physiological changes in estrogen synthesis capacity in the human body. Baseline levels in breasts, lungs and bones are low, supporting further investigation of this tracer as a new tool for detection of aromatase-overexpressing primary tumors or metastases in these organs and optimization of treatment in cancer and other disorders in which aromatase inhibitors are useful.

  16. Radiolabeled Peptide Scaffolds for PET/SPECT - Optical in Vivo Imaging of Carbohydrate-Lectin Interactions

    SciTech Connect (OSTI)

    Deutscher, Susan

    2014-09-30

    The objective of this research is to develop phage display-selected peptides into radio- and fluoresecently- labeled scaffolds for the multimodal imaging of carbohydrate-lectin interactions. While numerous protein and receptor systems are being explored for the development of targeted imaging agents, the targeting and analysis of carbohydrate-lectin complexes in vivo remains relatively unexplored. Antibodies, nanoparticles, and peptides are being developed that target carbohydrate-lectin complexes in living systems. However, antibodies and nanoparticles often suffer from slow clearance and toxicity problems. Peptides are attractive alternative vehicles for the specific delivery of radionuclides or fluorophores to sites of interest in vivo, although, because of their size, uptake and retention may be less than antibodies. We have selected high affinity peptides that bind a specific carbohydrate-lectin complex involved in cell-cell adhesion and cross-linking using bacteriophage (phage) display technologies (1,2). These peptides have allowed us to probe the role of these antigens in cell adhesion. Fluorescent versions of the peptides have been developed for optical imaging and radiolabeled versions have been used in single photon emission computed tomography (SPECT) and positron emission tomography (PET) in vivo imaging (3-6). A benefit in employing the radiolabeled peptides in SPECT and PET is that these imaging modalities are widely used in living systems and offer deep tissue sensitivity. Radiolabeled peptides, however, often exhibit poor stability and high kidney uptake in vivo. Conversely, optical imaging is sensitive and offers good spatial resolution, but is not useful for deep tissue penetration and is semi-quantitative. Thus, multimodality imaging that relies on the strengths of both radio- and optical- imaging is a current focus for development of new in vivo imaging agents. We propose a novel means to improve the efficacy of radiolabeled and fluorescently labeled peptides, including our lectin/carbohydrate- targeting peptides, by displaying the targeting epitopes on small ~29 amino acid cyclic plant protein scaffolds known as cyclotides. Cyclotides are extremely stable molecules with long serum half-lives and low kidney uptake (7). More than one copy of the peptide can be engineered into the cyclotide loops, thus increasing the avidity of the peptide construct for its target.

  17. Aromatase imaging with [N-methyl-C-11]vorozole PET in healthy men and women

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Biegon, Anat; Brookhaven National Lab.; Fowler, Joanna S.; State University of New York, Stony Brook, NY; Alexoff, David L.; Kim, Sung Won; Logan, Jean; Pareto, Deborah; Schlyer, David; Wang, Gene-Jack

    2015-02-19

    Aromatase, the last and obligatory enzyme catalyzing estrogen biosynthesis from androgenic precursors, can be labeled in vivo with ¹¹C-vorozole. Aromatase inhibitors are widely used in breast cancer and other endocrine conditions. The present study aims to provide baseline information defining aromatase distribution in healthy men and women, against which its perturbation in pathological situations can be studied. Methods: ¹¹C-vorozole (111-296 MBq/subject) was injected I.V in 13 men and 20 women (age range 23 to 67). PET data were acquired over a 90 minute period. Each subject had 4 scans, 2/day separated by 2-6 weeks, including brain and torso or pelvismore »scans. Young women were scanned at 2 discrete phases of the menstrual cycle (midcycle and late luteal). Men and postmenopausal women were also scanned following pretreatment with a clinical dose of the aromatase inhibitor letrozole (“blocking” studies). Time activity curves were obtained and standard uptake values (SUV) calculated for major organs including brain, heart, lungs, liver, kidneys, spleen, muscle, bone and male and female reproductive organs (penis, testes, uterus, ovaries). Organ and whole body radiation exposures were calculated using Olinda software. Results: Liver uptake was higher than all other organs, but was not blocked by pretreatment with letrozole. Mean SUVs in men were higher than in women, and brain uptake was blocked by letrozole. Male brain SUVs were also higher than all other organs (ranging from 0.48±0.05 in lungs to 1.5±0.13 in kidneys). Mean ovarian SUVs (3.08±0.7) were comparable to brain levels and higher than all other organs. Furthermore, ovarian SUVs In young women around the time of ovulation (midcycle) were significantly higher than those measured in the late luteal phase, while aging and cigarette smoking reduced ¹¹C-vorozole uptake. Conclusions: PET with ¹¹C-vorozole is useful for assessing physiological changes in estrogen synthesis capacity in the human body. Baseline levels in breasts, lungs and bones are low, supporting further investigation of this tracer as a new tool for detection of aromatase-overexpressing primary tumors or metastases in these organs and optimization of treatment in cancer and other disorders in which aromatase inhibitors are useful.« less

  18. Test of a single module of the J-PET scanner based on plastic scintillators

    E-Print Network [OSTI]

    P. Moskal; Sz. Nied?wiecki; T. Bednarski; E. Czerwi?ski; ?. Kap?on; E. Kubicz; I. Moskal; M. Pawlik-Nied?wiecka; N. G. Sharma; M. Silarski; M. Zieli?ski; N. Zo?; P. Bia?as; A. Gajos; A. Kochanowski; G. Korcyl; J. Kowal; P. Kowalski; T. Kozik; W. Krzemie?; M. Molenda; M. Pa?ka; L. Raczy?ski; Z. Rudy; P. Salabura; A. S?omski; J. Smyrski; A. Strzelecki; A. Wieczorek; W. Wi?licki

    2014-08-29

    Time of Flight Positron Emission Tomography scanner based on plastic scintillators is being developed at the Jagiellonian University by the J-PET collaboration. The main challenge of the conducted research lies in the elaboration of a method allowing application of plastic scintillators for the detection of low energy gamma quanta. In this article we report on tests of a single detection module built out from BC-420 plastic scintillator strip (with dimensions of 5x19x300mm^3) read out at two ends by Hamamatsu R5320 photomultipliers. The measurements were performed using collimated beam of annihilation quanta from the 68Ge isotope and applying the Serial Data Analyzer (Lecroy SDA6000A) which enabled sampling of signals with 50ps intervals. The time resolution of the prototype module was established to be better than 80ps (sigma) for a single level discrimination. The spatial resolution of the determination of the hit position along the strip was determined to be about 0.93cm (sigma) for the annihilation quanta. The fractional energy resolution for the energy E deposited by the annihilation quanta via the Compton scattering amounts to sigma(E)/E = 0.044/sqrt(E[MeV]) and corresponds to the sigma(E)/E of 7.5% at the Compton edge.

  19. Test of a single module of the J-PET scanner based on plastic scintillators

    E-Print Network [OSTI]

    Moskal, P; Bednarski, T; Czerwi?ski, E; Kap?on, ?; Kubicz, E; Moskal, I; Pawlik-Nied?wiecka, M; Sharma, N G; Silarski, M; Zieli?ski, M; Zo?, N; Bia?as, P; Gajos, A; Kochanowski, A; Korcyl, G; Kowal, J; Kowalski, P; Kozik, T; Krzemie?, W; Molenda, M; Pa?ka, M; Raczy?ski, L; Rudy, Z; Salabura, P; S?omski, A; Smyrski, J; Strzelecki, A; Wieczorek, A; Wi?licki, W

    2014-01-01

    Time of Flight Positron Emission Tomography scanner based on plastic scintillators is being developed at the Jagiellonian University by the J-PET collaboration. The main challenge of the conducted research lies in the elaboration of a method allowing application of plastic scintillators for the detection of low energy gamma quanta. In this article we report on tests of a single detection module built out from BC-420 plastic scintillator strip (with dimensions of 5x19x300mm^3) read out at two ends by Hamamatsu R5320 photomultipliers. The measurements were performed using collimated beam of annihilation quanta from the 68Ge isotope and applying the Serial Data Analyzer (Lecroy SDA6000A) which enabled sampling of signals with 50ps intervals. The time resolution of the prototype module was established to be better than 80ps (sigma) for a single level discrimination. The spatial resolution of the determination of the hit position along the strip was determined to be about 0.93cm (sigma) for the annihilation quanta...

  20. Synthesis of reduced graphene oxide/ZnO nanorods composites on graphene coated PET flexible substrates

    SciTech Connect (OSTI)

    Huang, Lei, E-mail: leihuang@shnu.edu.cn; Guo, Guilue; Liu, Yang; Chang, Quanhong; Shi, Wangzhou

    2013-10-15

    Graphical abstract: - Highlights: • ZnO nanorods synthesized on CVD-graphene and rGO surfaces, respectively. • ZnO/CVD-graphene and ZnO/rGO form a distinctive porous 3D structure. • rGO/ZnO nanostructures possibility in energy storage devices. - Abstract: In this work, reduced graphene oxide (rGO)/ZnO nanorods composites were synthesized on graphene coated PET flexible substrates. Both chemical vapor deposition (CVD) graphene and reduced graphene oxide (rGO) films were prepared following by hydrothermal growth of vertical aligned ZnO nanorods. Reduced graphene sheets were then spun coated on the ZnO materials to form a three dimensional (3D) porous nanostructure. The morphologies of the ZnO/CVD graphene and ZnO/rGO were investigated by SEM, which shows that the ZnO nanorods grown on rGO are larger in diameters and have lower density compared with those grown on CVD graphene substrate. As a result of fact, the rough surface of nano-scale ZnO on rGO film allows rGO droplets to seep into the large voids of ZnO nanorods, then to form the rGO/ZnO hierarchical structure. By comparison of the different results, we conclude that rGO/ZnO 3D nanostructure is more desirable for the application of energy storage devices.

  1. PET exam A 424304 20-032013 Short answers 111. Ex = Ex (O2) + Ex(N2) + Ex (unmix)

    E-Print Network [OSTI]

    Zevenhoven, Ron

    (303/293)+8,314*293*ln(5) = 2288,6 W Similar Ex (N2) = 3709,8 W, and Ex (unmix) = 3478,1 W Total = 9475PET exam ÅA 424304 20-032013 Short answers 111. Ex = Ex (O2) + Ex(N2) + Ex (unmix) Ex (O2) = (O2 --- Similar for N2. Ex (unmix) = · -R·T·(0.21ln0.21 + 079ln0.79) Ex (O2) = (2100/3600)*(29,4*10-293*29,4*ln

  2. Hit time and hit position reconstruction in the J-PET detector based on a library of averaged model signals

    E-Print Network [OSTI]

    P. Moskal; N. G. Sharma; M. Silarski; T. Bednarski; P. Bia?as; J. Bu?ka; E. Czerwi?ski; A. Gajos; D. Kami?ska; L. Kap?on; A. Kochanowski; G. Korcyl; J. Kowal; P. Kowalski; T. Kozik; W. Krzemie?; E. Kubicz; Sz. Nied?wiecki; M. Pa?ka; L. Raczy?ski; Z. Rudy; O. Rundel; P. Salabura; A. S?omski; J. Smyrski; A. Strzelecki; A. Wieczorek; W. Wi?licki; I. Wochlik; M. Zieli?ski; N. Zo?

    2015-02-27

    In this article we present a novel method of hit time and hit position reconstruction in long scintillator detectors. We take advantage of the fact that for this kind of detectors amplitude and shape of registered signals depends strongly on the position where particle hit the detector. The reconstruction is based on determination of the degree of similarity between measured and averaged signals stored in a library for a set of well-defined positions along the scintillator. Preliminary results of validation of the introduced method with experimental data obtained by means of the double strip prototype of the J-PET detector are presented.

  3. SU-E-J-104: Single Photon Image From PET with Insertable SPECT Collimator for Boron Neutron Capture Therapy: A Feasibility Study

    SciTech Connect (OSTI)

    Jung, J; Yoon, D; Suh, T

    2014-06-01

    Purpose: The aim of our proposed system is to confirm the feasibility of extraction of two types of images from one positron emission tomography (PET) module with an insertable collimator for brain tumor treatment during the BNCT. Methods: Data from the PET module, neutron source, and collimator was entered in the Monte Carlo n-particle extended (MCNPX) source code. The coincidence events were first compiled on the PET detector, and then, the events of the prompt gamma ray were collected after neutron emission by using a single photon emission computed tomography (SPECT) collimator on the PET. The obtaining of full width at half maximum (FWHM) values from the energy spectrum was performed to collect effective events for reconstructed image. In order to evaluate the images easily, five boron regions in a brain phantom were used. The image profiles were extracted from the region of interest (ROI) of a phantom. The image was reconstructed using the ordered subsets expectation maximization (OSEM) reconstruction algorithm. The image profiles and the receiver operating characteristic (ROC) curve were compiled for quantitative analysis from the two kinds of reconstructed image. Results: The prompt gamma ray energy peak of 478 keV appeared in the energy spectrum with a FWHM of 41 keV (6.4%). On the basis of the ROC curve in Region A to Region E, the differences in the area under the curve (AUC) of the PET and SPECT images were found to be 10.2%, 11.7%, 8.2% (center, Region C), 12.6%, and 10.5%, respectively. Conclusion: We attempted to acquire the PET and SPECT images simultaneously using only PET without an additional isotope. Single photon images were acquired using an insertable collimator on a PET detector. This research was supported by the Leading Foreign Research Institute Recruitment Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, Information and Communication Technologies (ICT) and Future Planning (MSIP)(Grant No.2009 00420) and the Radiation Technology R and D program (Grant No.2013M2A2A7043498), Republic of Korea.

  4. FDG-PET/CT Imaging Predicts Histopathologic Treatment Responses after Neoadjuvant Therapy in Adult Primary Bone Sarcomas

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Benz, Matthias R.; Czernin, Johannes; Tap, William D.; Eckardt, Jeffrey J.; Seeger, Leanne L.; Allen-Auerbach, Martin S.; Dry, Sarah M.; Phelps, Michael E.; Weber, Wolfgang A.; Eilber, Fritz C.

    2010-01-01

    Purpose. The aim of this study was to prospectively evaluate whether FDG-PET allows an accurate assessment of histopathologic response to neoadjuvant treatment in adult patients with primary bone sarcomas.Methods. Twelve consecutive patients with resectable, primary high grade bone sarcomas were enrolled prospectively. FDG-PET/CT imaging was performed prior to the initiation and after completion of neoadjuvant treatment. Imaging findings were correlated with histopathologic response.Results. Histopathologic responders showed significantly more pronounced decreases in tumor FDG-SUVmax from baseline to late follow up than non-responders (64±19% versus29±30%, resp.;P=.03). Using a 60% decrease in tumor FDG-uptake as a threshold for metabolic response correctly classified 3more »of 4 histopathologic responders and 7 of 8 histopathologic non-responders as metabolic responders and non-responders, respectively (sensitivity, 75%; specificity, 88%).Conclusion. These results suggest that changes in FDG-SUVmax at the end of neoadjuvant treatment can identify histopathologic responders and non-responders in adult primary bone sarcoma patients.« less

  5. Nuclear Instruments and Methods in Physics Research A 545 (2005) 436445 Under-sampling in PET scanners as a source of image blurring

    E-Print Network [OSTI]

    Thompson, Chris

    2005-01-01

    Nuclear Instruments and Methods in Physics Research A 545 (2005) 436­445 Under-sampling in PET; received in revised form 14 January 2005; accepted 20 January 2005 Available online 28 March 2005 Abstract-sampling; Block detectors 1. Introduction Spatial resolution and image noise are key factors in all instruments

  6. Effect of temperature on the release of intentionally and non-intentionally added substances from polyethylene terephthalate (PET) bottles into water

    E-Print Network [OSTI]

    Short, Daniel

    , 2,4-di-tert-butylphe- nol, a degradation compound of phenolic antioxidants, was detected itself, relevant impurities and foreseeable reaction and degradation products in the intended use'' (EU. Furthermore, PET can be degraded due to several exposure factors under normal conditions of use (heat and UV

  7. Porompomp-Poropmpomp. Le piace? un motivetto che ho inventato io. Anche lei viaggia spesso in treno? Io mi faccio tre

    E-Print Network [OSTI]

    Frosini, Patrizio

    ricordarmelo se lei non c'è, cioè quasi sempre. Qualche volta la incontro in ascensore, però non è facile intelligente. Quando arrivo a casa dal lavoro prendo l'ascensore fino al decimo, e poi scendo giù a piedi... e poi riprendo l'ascensore e poi riscendo giù a piedi... e poi riprendo l'ascensore e poi riscendo giù

  8. SU-D-9A-04: Brain PET/CT Imaging On a Scanner with a Large Axial Field-Of-View

    SciTech Connect (OSTI)

    Park, M; Gerbaudo, V; Hamberg, L; Seaver, K; Kijewski, M

    2014-06-01

    Purpose: Large axial field-of-view (FOV) PET/CT scanners are valued for high sensitivity. Brain PET image quality may depend on the head position within the FOV. We investigated the precision of activity estimation for brain PET imaging when the brain was positioned at the end (END) and in the middle (CEN) of the FOV. The additional CT dose for the CEN position was recorded. Methods: An image quality (Jaszczak) phantom and a striatal phantom were filled with F-18 and positioned in END and CEN locations. For each phantom and each location, we acquired a ?1-hr listmode PET, rebinned the data into 10 frames with equal number of coincidence events, and reconstructed each frame using an iterative algorithm. For the striatal phantom, END and CEN were compared by drawing on each image three regions of interest (ROI) in axially separated uniform areas. The standard deviation of the activity estimation within each ROI was averaged over the 10 images. The coefficient of variation (CV) for activity estimation was calculated at each position. Image quality was assessed by inspecting the resolution bar pattern in the Jaszczak phantom at two different head positions. Results: The CV was the lowest for ROIs near the center of the FOV. For slices near the end, not only was the CV highest, but also the resolution pattern was degraded. CTDIvol summarized in the dose report indicated that the CT dose was ? 10% higher for CEN as compared to END position. Conclusion: Positioning the brain in the middle of the FOV in a large FOV PET/CT scanner allows more precise measurement of tracer uptake and better image quality at the cost of increased CT dose. For the end location longer scan times may minimize image quality degradation without any additional CT dose.

  9. PET image reconstruction with system matrix based on point spread function derived from single photon incidence response

    E-Print Network [OSTI]

    Xin, Fan; Ming-Kai, Yun; Xiao-Li, Sun; Xue-Xiang, Cao; Shuang-Quanm, Liu; Pei, Chai; Dao-Wu, Li; Long, Wei

    2014-01-01

    In positron emission tomography (PET) imaging, statistical iterative reconstruction (IR) techniques appear particularly promising since they can provide accurate physical model and geometric system description. The reconstructed image quality mainly depends on the system matrix model which describes the relationship between image space and projection space for the IR method. The system matrix can contain some physics factors of detection such as geometrical component and blurring component. Point spread function (PSF) is generally used to describe the blurring component. This paper proposes an IR method based on the PSF system matrix, which is derived from the single photon incidence response function. More specifically, the gamma photon incidence on a crystal array is simulated by the Monte Carlo (MC) simulation, and then the single photon incidence response functions are obtained. Subsequently, using the single photon incidence response functions, the coincidence blurring factor is acquired according to the...

  10. The new bern PET cyclotron, its research beam line, and the development of an innovative beam monitor detector

    SciTech Connect (OSTI)

    Braccini, Saverio

    2013-04-19

    The new Bern cyclotron laboratory aims at industrial radioisotope production for PET diagnostics and multidisciplinary research by means of a specifically conceived beam transfer line, terminated in a separate bunker. In this framework, an innovative beam monitor detector based on doped silica and optical fibres has been designed, constructed, and tested. Scintillation light produced by Ce and Sb doped silica fibres moving across the beam is measured, giving information on beam position, shape, and intensity. The doped fibres are coupled to commercial optical fibres, allowing the read-out of the signal far away from the radiation source. This general-purpose device can be easily adapted for any accelerator used in medical applications and is suitable either for low currents used in hadrontherapy or for currents up to a few {mu}A for radioisotope production, as well as for both pulsed and continuous beams.

  11. 3D inpatient dose reconstruction from the PET-CT imaging of {sup 90}Y microspheres for metastatic cancer to the liver: Feasibility study

    SciTech Connect (OSTI)

    Fourkal, E.; Veltchev, I.; Lin, M.; Meyer, J.; Koren, S.; Doss, M.; Yu, J. Q.

    2013-08-15

    Purpose: The introduction of radioembolization with microspheres represents a significant step forward in the treatment of patients with metastatic disease to the liver. This technique uses semiempirical formulae based on body surface area or liver and target volumes to calculate the required total activity for a given patient. However, this treatment modality lacks extremely important information, which is the three-dimensional (3D) dose delivered by microspheres to different organs after their administration. The absence of this information dramatically limits the clinical efficacy of this modality, specifically the predictive power of the treatment. Therefore, the aim of this study is to develop a 3D dose calculation technique that is based on the PET imaging of the infused microspheres.Methods: The Fluka Monte Carlo code was used to calculate the voxel dose kernel for {sup 90}Y source with voxel size equal to that of the PET scan. The measured PET activity distribution was converted to total activity distribution for the subsequent convolution with the voxel dose kernel to obtain the 3D dose distribution. In addition, dose-volume histograms were generated to analyze the dose to the tumor and critical structures.Results: The 3D inpatient dose distribution can be reconstructed from the PET data of a patient scanned after the infusion of microspheres. A total of seven patients have been analyzed so far using the proposed reconstruction method. Four patients underwent treatment with SIR-Spheres for liver metastases from colorectal cancer and three patients were treated with Therasphere for hepatocellular cancer. A total of 14 target tumors were contoured on post-treatment PET-CT scans for dosimetric evaluation. Mean prescription activity was 1.7 GBq (range: 0.58–3.8 GBq). The resulting mean maximum measured dose to targets was 167 Gy (range: 71–311 Gy). Mean minimum dose to 70% of target (D70) was 68 Gy (range: 25–155 Gy). Mean minimum dose to 90% of target (D90) was 53 Gy (range: 13–125 Gy).Conclusions: A three-dimensional inpatient dose reconstruction method has been developed that is based on the PET/CT data of a patient treated with {sup 90}Y microspheres. It allows for a complete description of the absorbed dose by the tumor and critical structures. It represents the first step in building predictive models for treatment outcomes for patients receiving this therapeutic modality as well as it allows for better analysis of patients' dose response and will ultimately improve future treatment administration.

  12. Repeatability of quantitative FDG-PET/CT and contrast enhanced CT in recurrent ovarian carcinoma: test retest measurements for tumor FDG uptake, diameter and volume

    E-Print Network [OSTI]

    Rockall, Andrea G.; Avril, Norbert; Lam, Raymond; Iannone, Robert; Mozley, P. David; Parkinson, Christine; Bergstrom, Donald; Sala, Evis; Sarker, Shah-Jalal; McNeish, Iain A.; Brenton, James D.

    2014-02-26

    as appropriate, the same target lesions were chosen on PET and CECT. However, when an FDG-avid lesion was not suitable for RECIST measurements or vice versa, measurements on the other modality were not enforced. Thirty-five percent of subjects had different... , the majority of patients eventually develop progressive platinum-resistance. There is a clear unmet clinical need to identify new treatments for women with ovarian cancer. Evaluation of the effectiveness of new drug treatments in EOC depends upon...

  13. SU-E-J-250: A Methodology for Active Bone Marrow Protection for Cervical Cancer Intensity-Modulated Radiotherapy Using 18F-FLT PET/CT Image

    SciTech Connect (OSTI)

    Ma, C; Yin, Y

    2014-06-01

    Purpose: The purpose of this study was to compare a radiation therapy treatment planning that would spare active bone marrow and whole pelvic bone marrow using 18F FLT PET/CT image. Methods: We have developed an IMRT planning methodology to incorporate functional PET imaging using 18F FLT/CT scans. Plans were generated for two cervical cancer patients, where pelvicactive bone marrow region was incorporated as avoidance regions based on the range: SUV>2., another region was whole pelvic bone marrow. Dose objectives were set to reduce the volume of active bone marrow and whole bone marraw. The volumes of received 10 (V10) and 20 (V20) Gy for active bone marrow were evaluated. Results: Active bone marrow regions identified by 18F FLT with an SUV>2 represented an average of 48.0% of the total osseous pelvis for the two cases studied. Improved dose volume histograms for identified bone marrow SUV volumes and decreases in V10(average 18%), and V20(average 14%) were achieved without clinically significant changes to PTV or OAR doses. Conclusion: Incorporation of 18F FLT/CT PET in IMRT planning provides a methodology to reduce radiation dose to active bone marrow without compromising PTV or OAR dose objectives in cervical cancer.

  14. SU-E-QI-17: Dependence of 3D/4D PET Quantitative Image Features On Noise

    SciTech Connect (OSTI)

    Oliver, J; Budzevich, M; Zhang, G; Latifi, K; Dilling, T; Balagurunathan, Y; Gu, Y; Grove, O; Feygelman, V; Gillies, R; Moros, E; Lee, H.

    2014-06-15

    Purpose: Quantitative imaging is a fast evolving discipline where a large number of features are extracted from images; i.e., radiomics. Some features have been shown to have diagnostic, prognostic and predictive value. However, they are sensitive to acquisition and processing factors; e.g., noise. In this study noise was added to positron emission tomography (PET) images to determine how features were affected by noise. Methods: Three levels of Gaussian noise were added to 8 lung cancer patients PET images acquired in 3D mode (static) and using respiratory tracking (4D); for the latter images from one of 10 phases were used. A total of 62 features: 14 shape, 19 intensity (1stO), 18 GLCM textures (2ndO; from grey level co-occurrence matrices) and 11 RLM textures (2ndO; from run-length matrices) features were extracted from segmented tumors. Dimensions of GLCM were 256×256, calculated using 3D images with a step size of 1 voxel in 13 directions. Grey levels were binned into 256 levels for RLM and features were calculated in all 13 directions. Results: Feature variation generally increased with noise. Shape features were the most stable while RLM were the most unstable. Intensity and GLCM features performed well; the latter being more robust. The most stable 1stO features were compactness, maximum and minimum length, standard deviation, root-mean-squared, I30, V10-V90, and entropy. The most stable 2ndO features were entropy, sum-average, sum-entropy, difference-average, difference-variance, difference-entropy, information-correlation-2, short-run-emphasis, long-run-emphasis, and run-percentage. In general, features computed from images from one of the phases of 4D scans were more stable than from 3D scans. Conclusion: This study shows the need to characterize image features carefully before they are used in research and medical applications. It also shows that the performance of features, and thereby feature selection, may be assessed in part by noise analysis.

  15. Islet-selectivity of G-protein coupled receptor ligands evaluated for PET imaging of pancreatic {beta}-cell mass

    SciTech Connect (OSTI)

    Cline, Gary W.; Zhao, Xiaojian; Jakowski, Amy B.; Soeller, Walter C.; Treadway, Judith L.

    2011-09-02

    Highlights: {yields} We screened G-protein coupled receptors for imaging pancreatic. {yields} Database mining and immunohistochemistry identified GPCRs enriched in {beta}-cells. {yields} In vitro and in vivo assays were used to determine exocrine vs endocrine specificity. {yields} GPCR candidates for imaging of {beta}-cell mass are Prokineticin-1R, mGluR5, and GLP-1R. -- Abstract: A critical unmet need exists for methods to quantitatively measure endogenous pancreatic {beta}-cell mass (BCM) for the clinical evaluation of therapies to prevent or reverse loss of BCM and diabetes progression. Our objective was to identify G-protein coupled receptors (GPCRs) that are expressed with a high degree of specificity to islet {beta}-cells for receptor-targeted imaging of BCM. GPCRs enriched in pancreatic islets relative to pancreas acinar and hepatic tissue were identified using a database screen. Islet-specific expression was confirmed by human pancreas immunohistochemistry (IHC). In vitro selectivity assessment was determined from the binding and uptake of radiolabeled ligands to the rat insulinoma INS-1 832/13 cell line and isolated rat islets relative to the exocrine pancreas cell-type, PANC-1. Tail-vein injections of radioligands into rats were used to determine favorable image criteria of in vivo biodistribution to the pancreas relative to other internal organs (i.e., liver, spleen, stomach, and lungs). Database and IHC screening identified four candidate receptors for further in vitro and in vivo evaluation for PET imaging of BCM: prokineticin-1 receptor (PK-1R), metabotropic glutamate receptor type-5 (mGluR5), neuropeptide Y-2 receptor (NPY-2R), and glucagon-like peptide 1 receptor (GLP-1R). In vitro specificity ratios gave the following receptor rank order: PK-1R > GLP-1R > NPY-2R > mGluR5. The biodistribution rank order of selectivity to the pancreas was found to be PK-1R > VMAT2 {approx} GLP-1R > mGluR5. Favorable islet selectivity and biodistribution characteristics suggest several GPCRs as potential targets for PET imaging of pancreatic BCM.

  16. Clinical Value of [{sup 11}C]Methionine PET for Stereotactic Radiation Therapy With Intensity Modulated Radiation Therapy to Metastatic Brain Tumors

    SciTech Connect (OSTI)

    Miwa, Kazuhiro; Department of Clinical Brain Sciences, Gifu University Graduate School of Medicine, Minokamo, Gifu ; Matsuo, Masayuki; Shinoda, Jun; Aki, Tatsuki; Yonezawa, Shingo; Department of Clinical Brain Sciences, Gifu University Graduate School of Medicine, Minokamo, Gifu ; Ito, Takeshi; Asano, Yoshitaka; Department of Clinical Brain Sciences, Gifu University Graduate School of Medicine, Minokamo, Gifu ; Yamada, Mikito; Yokoyama, Kazutoshi; Yamada, Jitsuhiro; Yano, Hirohito; Iwama, Toru

    2012-12-01

    Purpose: This study investigated the clinical impact of {sup 11}C-labeled methionine-positron emission tomography (MET-PET) for stereotactic radiation therapy with intensity modulated radiation therapy (SRT-IMRT) in metastatic brain tumors. Methods and Materials: Forty-two metastatic brain tumors were examined. All tumors were treated with SRT-IMRT using a helical tomotherapy system. Gross tumor volume (GTV) was defined and drawn on the stereotactic magnetic resonance (MR) image, taking into account the respective contributions of MR imaging and MET-PET. Planning target volume (PTV) encompassed the GTV-PET plus a 2-mm margin. SRT-IMRT was performed, keeping the dose for PTV at 25-35 Gy in 5 fractions. The ratio of the mean value of MET uptake to the contralateral normal brain (L/N ratio) was plotted for the PTV prior to SRT-IMRT, at 3 months following SRT-IMRT, and at 6 months following SRT-IMRT. Tumor characteristic changes of MET uptake before and after SRT-IMRT were evaluated quantitatively, comparing them with MRI examination. Results: Mean {+-} SD L/N ratios were 1.95 {+-} 0.83, 1.18 {+-} 0.21, and 1.12 {+-} 0.25 in the pre-SRT-IMRT group, in the 3 months post-SRT-IMRT group, and in the 6 months post-SRT-IMRT group, respectively. Differences in the mean L/N ratio between the pre-SRT-IMRT group and the 3-month post-SRT-IMRT group and between the pre-SRT-IMRT group and the 6 month post-SRT-IMRT group were statistically significant, irrespective of MRI examination. Conclusions: We showed examples of metastatic lesions demonstrating significant decreases in MET uptake following SRT-IMRT. MET-PET seems to have a potential role in providing additional information, although MRI remains the gold standard for diagnosis and follow-up after SRT-IMRT. The present study is a preliminary approach, but to more clearly define the impact of PET-based radiosurgical assessment, further experimental and clinical analyses are required.

  17. Mathematical modeling of positron emission tomography (PET) data to assess radiofluoride transport in living plants following petiolar administration

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Converse, Alexander K.; Ahlers, Elizabeth O.; Bryan, Tom W.; Hetue, Jackson D.; Lake, Katherine A.; Ellison, Paul A.; Engle, Jonathan W.; Barnhart, Todd E.; Nickles, Robert J.; Williams, Paul H.; et al

    2015-03-15

    Background: Ion transport is a fundamental physiological process that can be studied non-invasively in living plants with radiotracer imaging methods. Fluoride is a known phytotoxic pollutant and understanding its transport in plants after leaf absorption is of interest to those in agricultural areas near industrial sources of airborne fluoride. Here we report the novel use of a commercial, high-resolution, animal positron emission tomography (PET) scanner to trace a bolus of [¹?F]fluoride administered via bisected petioles of Brassica oleracea, an established model species, to simulate whole plant uptake of atmospheric fluoride. This methodology allows for the first time mathematical compartmental modelingmore »of fluoride transport in the living plant. Radiotracer kinetics in the stem were described with a single-parameter free- and trapped-compartment model and mean arrival times at different stem positions were calculated from the free-compartment time-activity curves. Results: After initiation of administration at the bisected leaf stalk, [¹?F] radioactivity climbed for approximately 10 minutes followed by rapid washout from the stem and equilibration within leaves. Kinetic modeling of transport in the stem yielded a trapping rate of 1.5 +/- 0.3%/min (mean +/- s.d., n = 3), velocity of 2.2 +/- 1.1 cm/min, and trapping fraction of 0.8 +/- 0.5%/cm. Conclusion: Quantitative assessment of physiologically meaningful transport parameters of fluoride in living plants is possible using standard positron emission tomography in combination with petiolar radiotracer administration. Movement of free fluoride was observed to be consistent with bulk flow in xylem, namely a rapid and linear change in position with respect to time. Trapping, likely in the apoplast, was observed. Future applications of the methods described here include studies of transport of other ions and molecules of interest in plant physiology.« less

  18. Mathematical modeling of positron emission tomography (PET) data to assess radiofluoride transport in living plants following petiolar administration

    SciTech Connect (OSTI)

    Converse, Alexander K. [Univ. of Wisconsin, Madison, WI (United States); Ahlers, Elizabeth O. [Univ. of Wisconsin, Madison, WI (United States); Bryan, Tom W. [Univ. of Wisconsin, Madison, WI (United States); Hetue, Jackson D. [Univ. of Wisconsin, Madison, WI (United States); Lake, Katherine A. [Univ. of Wisconsin, Madison, WI (United States); Ellison, Paul A. [Univ. of Wisconsin, Madison, WI (United States); Engle, Jonathan W. [Univ. of Wisconsin, Madison, WI (United States); Barnhart, Todd E. [Univ. of Wisconsin, Madison, WI (United States); Nickles, Robert J. [Univ. of Wisconsin, Madison, WI (United States); Williams, Paul H. [Univ. of Wisconsin, Madison, WI (United States); DeJesus, Onofre T. [Univ. of Wisconsin, Madison, WI (United States)

    2015-01-01

    Background: Ion transport is a fundamental physiological process that can be studied non-invasively in living plants with radiotracer imaging methods. Fluoride is a known phytotoxic pollutant and understanding its transport in plants after leaf absorption is of interest to those in agricultural areas near industrial sources of airborne fluoride. Here we report the novel use of a commercial, high-resolution, animal positron emission tomography (PET) scanner to trace a bolus of [¹?F]fluoride administered via bisected petioles of Brassica oleracea, an established model species, to simulate whole plant uptake of atmospheric fluoride. This methodology allows for the first time mathematical compartmental modeling of fluoride transport in the living plant. Radiotracer kinetics in the stem were described with a single-parameter free- and trapped-compartment model and mean arrival times at different stem positions were calculated from the free-compartment time-activity curves. Results: After initiation of administration at the bisected leaf stalk, [¹?F] radioactivity climbed for approximately 10 minutes followed by rapid washout from the stem and equilibration within leaves. Kinetic modeling of transport in the stem yielded a trapping rate of 1.5 +/- 0.3%/min (mean +/- s.d., n = 3), velocity of 2.2 +/- 1.1 cm/min, and trapping fraction of 0.8 +/- 0.5%/cm. Conclusion: Quantitative assessment of physiologically meaningful transport parameters of fluoride in living plants is possible using standard positron emission tomography in combination with petiolar radiotracer administration. Movement of free fluoride was observed to be consistent with bulk flow in xylem, namely a rapid and linear change in position with respect to time. Trapping, likely in the apoplast, was observed. Future applications of the methods described here include studies of transport of other ions and molecules of interest in plant physiology.

  19. {sup 18}F-FLT uptake kinetics in head and neck squamous cell carcinoma: A PET imaging study

    SciTech Connect (OSTI)

    Liu, Dan Fenwick, John D.; Chalkidou, Anastasia; Landau, David B.; Marsden, Paul K.

    2014-04-15

    Purpose: To analyze the kinetics of 3{sup ?}-deoxy-3{sup ?}-[F-18]-fluorothymidine (18F-FLT) uptake by head and neck squamous cell carcinomas and involved nodes imaged using positron emission tomography (PET). Methods: Two- and three-tissue compartment models were fitted to 12 tumor time-activity-curves (TACs) obtained for 6 structures (tumors or involved nodes) imaged in ten dynamic PET studies of 1 h duration, carried out for five patients. The ability of the models to describe the data was assessed using a runs test, the Akaike information criterion (AIC) and leave-one-out cross-validation. To generate parametric maps the models were also fitted to TACs of individual voxels. Correlations between maps of different parameters were characterized using Pearson'sr coefficient; in particular the phosphorylation rate-constants k{sub 3-2tiss} and k{sub 5} of the two- and three-tissue models were studied alongside the flux parameters K{sub FLT-2tiss} and K{sub FLT} of these models, and standardized uptake values (SUV). A methodology based on expectation-maximization clustering and the Bayesian information criterion (“EM-BIC clustering”) was used to distil the information from noisy parametric images. Results: Fits of two-tissue models 2C3K and 2C4K and three-tissue models 3C5K and 3C6K comprising three, four, five, and six rate-constants, respectively, pass the runs test for 4, 8, 10, and 11 of 12 tumor TACs. The three-tissue models have lower AIC and cross-validation scores for nine of the 12 tumors. Overall the 3C6K model has the lowest AIC and cross-validation scores and its fitted parameter values are of the same orders of magnitude as literature estimates. Maps ofK{sub FLT} and K{sub FLT-2tiss} are strongly correlated (r = 0.85) and also correlate closely with SUV maps (r = 0.72 for K{sub FLT-2tiss}, 0.64 for K{sub FLT}). Phosphorylation rate-constant maps are moderately correlated with flux maps (r = 0.48 for k{sub 3-2tiss} vs K{sub FLT-2tiss} and r = 0.68 for k{sub 5} vs K{sub FLT}); however, neither phosphorylation rate-constant correlates significantly with SUV. EM-BIC clustering reduces the parametric maps to a small number of levels—on average 5.8, 3.5, 3.4, and 1.4 for K{sub FLT-2tiss}, K{sub FLT}, k{sub 3-2tiss}, and k{sub 5.} This large simplification is potentially useful for radiotherapy dose-painting, but demonstrates the high noise in some maps. Statistical simulations show that voxel level noise degrades TACs generated from the 3C6K model sufficiently that the average AIC score, parameter bias, and total uncertainty of 2C4K model fits are similar to those of 3C6K fits, whereas at the whole tumor level the scores are lower for 3C6K fits. Conclusions: For the patients studied here, whole tumor FLT uptake time-courses are represented better overall by a three-tissue than by a two-tissue model. EM-BIC clustering simplifies noisy parametric maps, providing the best description of the underlying information they contain and is potentially useful for radiotherapy dose-painting. However, the clustering highlights the large degree of noise present in maps of the phosphorylation rate-constantsk{sub 5} and k{sub 3-2tiss}, which are conceptually tightly linked to cellular proliferation. Methods must be found to make these maps more robust—either by constraining other model parameters or modifying dynamic imaging protocols.

  20. Human Dosimetry and Preliminary Tumor Distribution of (superscript)18F-Fluoropaclitaxel in Healthy Volunteers and Newly Diagnosed Breast Cancer Patients Using PET/CT

    SciTech Connect (OSTI)

    Kurdziel, K.A.; Logan, J.; Kurdziel, K.A.; Kalen, J.D.; Hirsch, J.I.; Wilson, J.D.; Bear, H.D.; Logan, J.; McCumisky, J.; Moorman-Sykes, K.; Adler, S.; Choyke, P.L.

    2011-08-17

    {sup 18}F-fluoropaclitaxel is a radiolabeled form of paclitaxel, a widely used chemotherapy agent. Preclinical data suggest that {sup 18}F-fluoropaclitaxel may be a reasonable surrogate for measuring the uptake of paclitaxel. As a substrate of P-glycoprotein, a drug efflux pump associated with multidrug resistance, {sup 18}F-fluoropaclitaxel may also be useful in identifying multidrug resistance and predicting tumor response for drugs other than paclitaxel. After informed consent was obtained, 3 healthy volunteers and 3 patients with untreated breast cancer (neoadjuvant chemotherapy candidates, tumor size > 2 cm) received an intravenous infusion of {sup 18}F-fluoropaclitaxel and then underwent PET/CT. Healthy volunteers underwent serial whole-body imaging over an approximately 3-h interval, and organ {sup 18}F residence times were determined from the time-activity curves uncorrected for decay to determine dosimetry. Radiation dose estimates were calculated using OLINDA/EXM software. For breast cancer patients, dynamic imaging of the primary tumor was performed for 60 min, followed by static whole-body scans at 1 and 2 h after injection. Dosimetry calculations showed that the gallbladder received the highest dose (229.50 {mu}Gy/MBq [0.849 rad/mCi]), followed by the small and large intestines (161.26 {mu}Gy/MBq [0.597 rad/mCi] and 184.59 {mu}Gy/MBq [0.683 rad/mCi]). The resultant effective dose was 28.79 {mu}Gy/MBq (0.107 rem/mCi). At approximately 1 h after injection, an average of 42% of the decay-corrected activity was in the gastrointestinal system, with a mean of 0.01% in the tumor. All 3 breast cancer patients showed retention of {sup 18}F-fluoropaclitaxel and ultimately demonstrated a complete pathologic response (no invasive cancer in the breast or axillary nodes) to chemotherapy that included a taxane (either paclitaxel or docetaxel) at surgical resection. The tumor-to-background ratio increased with time to a maximum of 7.7 at 20 min. This study demonstrates the feasibility of using {sup 18}F-fluoropaclitaxel PET/CT tumor imaging and provides radiation dosimetry measurements in humans. Although further study is needed, it is hoped that the measured intratumoral {sup 18}F-fluoropaclitaxel distribution can serve as a surrogate for paclitaxel, and potentially other chemotherapeutic agent retention, in solid tumors.

  1. Tumor Metabolism and Perfusion in Head and Neck Squamous Cell Carcinoma: Pretreatment Multimodality Imaging With {sup 1}H Magnetic Resonance Spectroscopy, Dynamic Contrast-Enhanced MRI, and [{sup 18}F]FDG-PET

    SciTech Connect (OSTI)

    Jansen, Jacobus F.A.; Schoeder, Heiko; Lee, Nancy Y.; Stambuk, Hilda E.; Wang Ya; Fury, Matthew G.; Patel, Senehal G.; Pfister, David G.; Shah, Jatin P.; Koutcher, Jason A.; Shukla-Dave, Amita

    2012-01-01

    Purpose: To correlate proton magnetic resonance spectroscopy ({sup 1}H-MRS), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and {sup 18}F-labeled fluorodeoxyglucose positron emission tomography ([{sup 18}F]FDG PET) of nodal metastases in patients with head and neck squamous cell carcinoma (HNSCC) for assessment of tumor biology. Additionally, pretreatment multimodality imaging was evaluated for its efficacy in predicting short-term response to treatment. Methods and Materials: Metastatic neck nodes were imaged with {sup 1}H-MRS, DCE-MRI, and [{sup 18}F]FDG PET in 16 patients with newly diagnosed HNSCC, before treatment. Short-term patient radiological response was evaluated at 3 to 4 months. Correlations among {sup 1}H-MRS (choline concentration relative to water [Cho/W]), DCE-MRI (volume transfer constant [K{sup trans}]; volume fraction of the extravascular extracellular space [v{sub e}]; and redistribution rate constant [k{sub ep}]), and [{sup 18}F]FDG PET (standard uptake value [SUV] and total lesion glycolysis [TLG]) were calculated using nonparametric Spearman rank correlation. To predict short-term responses, logistic regression analysis was performed. Results: A significant positive correlation was found between Cho/W and TLG ({rho} = 0.599; p = 0.031). Cho/W correlated negatively with heterogeneity measures of standard deviation std(v{sub e}) ({rho} = -0.691; p = 0.004) and std(k{sub ep}) ({rho} = -0.704; p = 0.003). Maximum SUV (SUVmax) values correlated strongly with MRI tumor volume ({rho} = 0.643; p = 0.007). Logistic regression indicated that std(K{sup trans}) and SUVmean were significant predictors of short-term response (p < 0.07). Conclusion: Pretreatment multimodality imaging using {sup 1}H-MRS, DCE-MRI, and [{sup 18}F]FDG PET is feasible in HNSCC patients with nodal metastases. Additionally, combined DCE-MRI and [{sup 18}F]FDG PET parameters were predictive of short-term response to treatment.

  2. A novel method for the line-of-response and time-of-flight reconstruction in TOF-PET detectors based on a library of synchronized model signals

    E-Print Network [OSTI]

    P. Moskal; N. Zo?; T. Bednarski; P. Bia?as; E. Czerwi?ski; A. Gajos; D. Kami?ska; ?. Kap?on; A. Kochanowski; G. Korcyl; J. Kowal; P. Kowalski; T. Kozik; W. Krzemie?; E. Kubicz; Sz. Nied?wiecki; M. Pa?ka; L. Raczy?ski; Z. Rudy; O. Rundel; P. Salabura; N. G. Sharma; M. Silarski; A. S?omski; J. Smyrski; A. Strzelecki; A. Wieczorek; W. Wi?licki; M. Zieli?ski

    2015-02-10

    A novel method of hit time and hit position reconstruction in scintillator detectors is described. The method is based on comparison of detector signals with results stored in a library of synchronized model signals registered for a set of well-defined positions of scintillation points. The hit position is reconstructed as the one corresponding to the signal from the library which is most similar to the measurement signal. The time of the interaction is determined as a relative time between the measured signal and the most similar one in the library. A degree of similarity of measured and model signals is defined as the distance between points representing the measurement- and model-signal in the multi-dimensional measurement space. Novelty of the method lies also in the proposed way of synchronization of model signals enabling direct determination of the difference between time-of-flights (TOF) of annihilation quanta from the annihilation point to the detectors. The introduced method was validated using experimental data obtained by means of the double strip prototype of the J-PET detector and $^{22}$Na sodium isotope as a source of annihilation gamma quanta.The detector was built out from plastic scintillator strips with dimensions of 5 mm x 19 mm x 300 mm, optically connected at both sides to photomultipliers,from which signals were sampled by means of the Serial Data Analyzer.Using the introduced method, the spatial and TOF resolution of about 1.3 cm ($\\sigma$) and 125 ps ($\\sigma$) were established, respectively.

  3. PET 424304 2015 Exercises 1+2 of 4 16 Jan + 30 Jan 2015 1. 1kg ice at 263 K 1 kg water at 293 K. Heat Q at T = T is supplied by the surroundings.

    E-Print Network [OSTI]

    Zevenhoven, Ron

    ,340] = 293·[(-21,99 ­ 5,339) + (149,13 ­ 65,13)·0,34)] = 361 (W/s)/mol ice The same result is found via lost,340·5141 = 1750 W/mol ice xout/H2O = 491,8 + 0,340·2612 = 1381 W/mol ice EX = 1381 / 1750 = 0/mol for ex4 PET 424304 2015 Exercises 1+2 of 4 16 Jan + 30 Jan 2015 3. Wmin = Ex°separation = 0,79·Ex°N2

  4. Method for selective recovery of PET-usable quantities of [.sup.18 F] fluoride and [.sup.13 N] nitrate/nitrite from a single irradiation of low-enriched [.sup.18 O] water

    DOE Patents [OSTI]

    Ferrieri, Richard A. (Patchogue, NY); Schlyer, David J. (Bellport, NY); Shea, Colleen (Wading River, NY)

    1995-06-13

    A process for simultaneously producing PET-usable quantities of [.sup.13 N]NH.sub.3 and [.sup.18 F]F.sup.- for radiotracer synthesis is disclosed. The process includes producing [.sup.13 N]NO.sub.2.sup.- /NO.sub.3.sup.- and [.sup.18 F]F.sup.- simultaneously by exposing a low-enriched (20%-30%) [.sup.18 O]H.sub.2 O target to proton irradiation, sequentially isolating the [.sup.13 N]NO.sub.2.sup.- /NO.sub.3.sup.- and [.sup.18 F]F.sup.- from the [.sup.18 O]H.sub.2 O target, and reducing the [.sup.13 N]NO.sub.2.sup.- /NO.sub.3.sup.- to [.sup.13 N]NH.sub.3. The [.sup.13 N]NH.sub.3 and [.sup.18 F]F.sup.- products are then conveyed to a laboratory for radiotracer applications. The process employs an anion exchange resin for isolation of the isotopes from the [.sup.18 O]H.sub.2 O, and sequential elution of [.sup.13 N]NO.sub.2.sup.- /NO.sub.3.sup.- and [ .sup.18 F]F.sup.- fractions. Also the apparatus is disclosed for simultaneously producing PET-usable quantities of [.sup.13 N]NH.sub.3 and [.sup.18 F]F.sup.- from a single irradiation of a single low-enriched [.sup.18 O]H.sub.2 O target.

  5. Application of Two Phase (Liquid/Gas) Xenon Gamma-Camera for the Detection of Special Nuclear Material and PET Medical Imaging

    SciTech Connect (OSTI)

    McKinsey, Daniel Nicholas

    2013-08-27

    The McKinsey group at Yale has been awarded a grant from DTRA for the building of a Liquid Xenon Gamma Ray Color Camera (LXe-GRCC), which combines state-of-the-art detection of LXe scintillation light and time projection chamber (TPC) charge readout. The DTRA application requires a movable detector and hence only a single phase (liquid) xenon detector can be considered in this case. We propose to extend the DTRA project to applications that allow a two phase (liquid/gas) xenon TPC. This entails additional (yet minimal) hardware and extension of the research effort funded by DTRA. The two phase detector will have better energy and angular resolution. Such detectors will be useful for PET medical imaging and detection of special nuclear material in stationary applications (e.g. port of entry). The expertise of the UConn group in gas phase TPCs will enhance the capabilities of the Yale group and the synergy between the two groups will be very beneficial for this research project as well as the education and research projects of the two universities. The LXe technology to be used in this project has matured rapidly over the past few years, developed for use in detectors for nuclear physics and astrophysics. This technology may now be applied in a straightforward way to the imaging of gamma rays. According to detailed Monte Carlo simulations recently performed at Yale University, energy resolution of 1% and angular resolution of 3 degrees may be obtained for 1.0 MeV gamma rays, using existing technology. With further research and development, energy resolution of 0.5% and angular resolution of 1.3 degrees will be possible at 1.0 MeV. Because liquid xenon is a high density, high Z material, it is highly efficient for scattering and capturing gamma rays. In addition, this technology scales elegantly to large detector areas, with several square meter apertures possible. The Yale research group is highly experienced in the development and use of noble liquid detectors for astrophysics, most recently in the XENON10 experiment. The existing facilities at Yale are fully adequate for the completion of this project. The facilities of the UConn group at the LNS at Avery Point include a (clean) lab for detector development and this group recently delivered an Optical Readout TPC (O-TPC) for research in Nuclear Astrophysics at the TUNL in Duke University. The machine shop at UConn will be used (free of charge) for producing the extra hardware needed for this project including grids and frames.

  6. Volumetric-modulated arc therapy (RapidArc) vs. conventional fixed-field intensity-modulated radiotherapy for {sup 18}F-FDG-PET-guided dose escalation in oropharyngeal cancer: A planning study

    SciTech Connect (OSTI)

    Teoh, May, E-mail: m.teoh@nhs.net [Department of Oncology, St. Luke's Cancer Centre, Royal Surrey County Hospital, Guildford, Surrey (United Kingdom); Beveridge, Sabeena [Department of Medical Physics, St. Luke's Cancer Centre, Royal Surrey County Hospital, Guildford, Surrey (United Kingdom); Wood, Katie; Whitaker, Stephen [Department of Oncology, St. Luke's Cancer Centre, Royal Surrey County Hospital, Guildford, Surrey (United Kingdom); Adams, Elizabeth; Rickard, Donna; Jordan, Tom; Nisbet, Andrew [Department of Medical Physics, St. Luke's Cancer Centre, Royal Surrey County Hospital, Guildford, Surrey (United Kingdom); Clark, Catharine H. [Department of Medical Physics, St. Luke's Cancer Centre, Royal Surrey County Hospital, Guildford, Surrey (United Kingdom); National Physical Laboratory, Hampton Road, Teddington, Middlesex (United Kingdom)

    2013-04-01

    Fluorine-18-fluorodeoxyglucose-positron emission tomography ({sup 18}F-FDG-PET)–guided focal dose escalation in oropharyngeal cancer may potentially improve local control. We evaluated the feasibility of this approach using volumetric-modulated arc therapy (RapidArc) and compared these plans with fixed-field intensity-modulated radiotherapy (IMRT) focal dose escalation plans. Materials and methods: An initial study of 20 patients compared RapidArc with fixed-field IMRT using standard dose prescriptions. From this cohort, 10 were included in a dose escalation planning study. Dose escalation was applied to {sup 18}F-FDG-PET–positive regions in the primary tumor at dose levels of 5% (DL1), 10% (DL2), and 15% (DL3) above standard radical dose (65 Gy in 30 fractions). Fixed-field IMRT and double-arc RapidArc plans were generated for each dataset. Dose-volume histograms were used for plan evaluation and comparison. The Paddick conformity index (CI{sub Paddick}) and monitor units (MU) for each plan were recorded and compared. Both IMRT and RapidArc produced clinically acceptable plans and achieved planning objectives for target volumes. Dose conformity was significantly better in the RapidArc plans, with lower CI{sub Paddick} scores in both primary (PTV1) and elective (PTV2) planning target volumes (largest difference in PTV1 at DL3; 0.81 ± 0.03 [RapidArc] vs. 0.77 ± 0.07 [IMRT], p = 0.04). Maximum dose constraints for spinal cord and brainstem were not exceeded in both RapidArc and IMRT plans, but mean doses were higher with RapidArc (by 2.7 ± 1 Gy for spinal cord and 1.9 ± 1 Gy for brainstem). Contralateral parotid mean dose was lower with RapidArc, which was statistically significant at DL1 (29.0 vs. 29.9 Gy, p = 0.01) and DL2 (29.3 vs. 30.3 Gy, p = 0.03). MU were reduced by 39.8–49.2% with RapidArc (largest difference at DL3, 641 ± 94 vs. 1261 ± 118, p < 0.01). {sup 18}F-FDG-PET–guided focal dose escalation in oropharyngeal cancer is feasible with RapidArc. Compared with conventional fixed-field IMRT, RapidArc can achieve better dose conformity, improve contralateral parotid sparing, and uses fewer MU.

  7. PET Studies of CX-157

    SciTech Connect (OSTI)

    Fowler, Joanna

    2008-10-25

    We completed measuring Brain MAO A activity in 15 subjects at baseline and after different doses of CX157 and also at different times after each dose. Fifty five scans were completed. We determined that plasma levels of the drug are a surrogate marker for the degree of MAO A inhibition in the brain.

  8. Method for selective recovery of PET-usable quantities of [{sup 18}F] fluoride and [{sup 13}N] nitrate/nitrite from a single irradiation of low-enriched [{sup 18}O] water

    DOE Patents [OSTI]

    Ferrieri, R.A.; Schlyer, D.J.; Shea, C.

    1995-06-13

    A process for simultaneously producing PET-usable quantities of [{sup 13}N]NH{sub 3} and [{sup 18}F]F{sup {minus}} for radiotracer synthesis is disclosed. The process includes producing [{sup 13}N]NO{sub 2}{sup {minus}}/NO{sub 3}{sup {minus}}and [{sup 18}F]F{sup {minus}} simultaneously by exposing a low-enriched (20%-30%) [{sup 18}O]H{sub 2}O target to proton irradiation, sequentially isolating the [{sup 13}N]NO{sub 2}{sup {minus}}/NO{sub 3}{sup {minus}} and [{sup 18}F]F{sup {minus}} from the [{sup 18}O]H{sub 2}O target, and reducing the [{sup 13}N]NO{sub 2}{sup {minus}}/NO{sub 3}{sup {minus}} to [{sup 13}N]NH{sub 3}. The [{sup 13}N]NH{sub 3} and [{sup 18}F]F{sup {minus}} products are then conveyed to a laboratory for radiotracer applications. The process employs an anion exchange resin for isolation of the isotopes from the [{sup 18}O]H{sub 2}O, and sequential elution of [{sup 13}N]NO{sub 2}{sup {minus}}/NO{sub 3}{sup {minus}} and [{sup 18}F]F{sup {minus}} fractions. Also the apparatus is disclosed for simultaneously producing PET-usable quantities of [{sup 13}N]NH{sub 3} and [{sup 18}F]F{sup {minus}} from a single irradiation of a single low-enriched [{sup 18}O]H{sub 2}O target. 2 figs.

  9. Dipartimento di Architettura e Progetto "Sapienza" Universit di Roma

    E-Print Network [OSTI]

    Di Pillo, Gianni

    'architettura bioclimatica e della sostenibilità ambientale Presentando nel curriculum vitae: a) I titoli di studio (anche

  10. 26 novembre 2010 -12:31 L'Atlante della Svizzera con nuove sorprese

    E-Print Network [OSTI]

    Giger, Christine

    meteorologia possono presentare panorami, collocandovi nuvole a piacimento. Anche gli appassionati dell

  11. Da "Sui vostri passi" Epifanie di un Padre

    E-Print Network [OSTI]

    Bressan, Alberto

    spostamenti sarebbe, credo, un'impresa stimolante ma terribilmente difficile. Focalizzare lo sguardo, anche

  12. Ruggero Ferro LOGICA MATEMATICA

    E-Print Network [OSTI]

    Bellin, Gianluigi

    . Ho richiamato questa osservazione perché credo si applichi bene anche a varie altre nozioni, oltre

  13. Introduzione al Grid Computing Definizione di griglia computazionale

    E-Print Network [OSTI]

    Ricci, Laura

    sismica) ........ ­ ....... #12;Risorse Condivise (II) Ambienti eterogenei (anche tra dispositivi dello

  14. UNIVERSIT`A DEGLI STUDI DI PERUGIA Facolt`a di Scienze MM. FF. e NN.

    E-Print Network [OSTI]

    Filippucci, Roberta

    gravemente non solo sul comportamento ma anche sulla fisiologia. Si considerano 12560 balene che vivono nell

  15. Bando con scadenza 24 aprile 2009 promuoVere la SoSteNIbIlIt

    E-Print Network [OSTI]

    De Cindio, Fiorella

    'alte- razione della funzionalità degli ecosistemi ha quindi anche un impatto economico: variazioni della

  16. MuSa, acronimo di Musica Sapienza, significa fare, ascoltare,

    E-Print Network [OSTI]

    Di Pillo, Gianni

    spese gestionali ordinarie ed agli onorari dei soli maestri professionisti. Grazie anche all'efficienza

  17. Tiziana Catarci www.sapienzafutura.it -tiziana@sapienzafutura.it -info@sapienzafutura.it mob. +39 3661216427

    E-Print Network [OSTI]

    Di Pillo, Gianni

    , unita, partecipe, egualitaria, condivisa, immaginifica, ma anche decorosa, efficiente, seria, concreta e

  18. An open-label, randomized positron emission tomography (PET) study in healthy male volunteers consisiting of Part A and Part B. Part A: Clinical validation of norepinephrine transporter (NET) PET ligand, (S,S)-[11C]O-methylreboxetine ([11C]MRB) using different doses of oral atomoxetine as NET reuptake inhibitor. Part B: Evaluation of NET occupancy, as measured by [11C]MRB, with multiple dosing regimens of orally administered GSK372475.

    SciTech Connect (OSTI)

    Fowler, Joanna

    2007-08-31

    Results from human studies with the PET radiotracer (S,S)-[(11)C]O-methyl reboxetine ([(11)C](S,S)-MRB), a ligand targeting the norepinephrine transporter (NET), are reported. Quantification methods were determined from test/retest studies, and sensitivity to pharmacological blockade was tested with different doses of atomoxetine (ATX), a drug that binds to the NET with high affinity (K(i)=2-5 nM). METHODS: Twenty-four male subjects were divided into different groups for serial 90-min PET studies with [(11)C](S,S)-MRB to assess reproducibility and the effect of blocking with different doses of ATX (25, 50 and 100 mg, po). Region-of-interest uptake data and arterial plasma input were analyzed for the distribution volume (DV). Images were normalized to a template, and average parametric images for each group were formed. RESULTS: [(11)C](S,S)-MRB uptake was highest in the thalamus (THL) and the midbrain (MBR) [containing the locus coeruleus (LC)] and lowest for the caudate nucleus (CDT). The CDT, a region with low NET, showed the smallest change on ATX treatment and was used as a reference region for the DV ratio (DVR). The baseline average DVR was 1.48 for both the THL and MBR with lower values for other regions [cerebellum (CB), 1.09; cingulate gyrus (CNG) 1.07]. However, more accurate information about relative densities came from the blocking studies. MBR exhibited greater blocking than THL, indicating a transporter density approximately 40% greater than THL. No relationship was found between DVR change and plasma ATX level. Although the higher dose tended to induce a greater decrease than the lower dose for MBR (average decrease for 25 mg=24+/-7%; 100 mg=31+/-11%), these differences were not significant. The different blocking between MBR (average decrease=28+/- 10%) and THL (average decrease=17+/-10%) given the same baseline DVR indicates that the CDT is not a good measure for non-NET binding in both regions. Threshold analysis of the difference between the average baseline DV image and the average blocked image showed the expected NET distribution with the MBR (LC) and hypothalamus>THL>CNG and CB, as well as a significant change in the supplementary motor area. DVR reproducibility for the different brain regions was approximately 10%, but intersubject variability was large. CONCLUSIONS: The highest density of NETs was found in the MBR where the LC is located, followed by THL, whereas the lowest density was found in basal ganglia (lowest in CDT), consistent with the regional localization of NETs in the nonhuman primate brain. While all three doses of ATX were found to block most regions, no significant differences between doses were found for any region, although the average percent change across subjects of the MBR did correlate with ATX dose. The lack of a dose effect could reflect a low signal-to-noise ratio coupled with the possibility that a sufficient number of transporters were blocked at the lowest dose and further differences could not be detected. However, since the lowest (25 mg) dose is less than the therapeutic doses used in children for the treatment of attention-deficit/hyperactivity disorder ( approximately 1.0 mg/kg/day), this would suggest that there may be additional targets for ATX's therapeutic actions.

  19. Adaptation of the modified Bouc–Wen model to compensate for hysteresis in respiratory motion for the list-mode binning of cardiac SPECT and PET acquisitions: Testing using MRI

    SciTech Connect (OSTI)

    Dasari, Paul K. R.; Shazeeb, Mohammed Salman [Department of Radiology, Division of Nuclear Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655 and Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts 01609 (United States); Könik, Arda; Lindsay, Clifford; Mukherjee, Joyeeta M.; Johnson, Karen L.; King, Michael A., E-mail: Michael.King@umassmed.edu [Department of Radiology, Division of Nuclear Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655 (United States)

    2014-11-01

    Purpose: Binning list-mode acquisitions as a function of a surrogate signal related to respiration has been employed to reduce the impact of respiratory motion on image quality in cardiac emission tomography (SPECT and PET). Inherent in amplitude binning is the assumption that there is a monotonic relationship between the amplitude of the surrogate signal and respiratory motion of the heart. This assumption is not valid in the presence of hysteresis when heart motion exhibits a different relationship with the surrogate during inspiration and expiration. The purpose of this study was to investigate the novel approach of using the Bouc–Wen (BW) model to provide a signal accounting for hysteresis when binning list-mode data with the goal of thereby improving motion correction. The study is based on the authors’ previous observations that hysteresis between chest and abdomen markers was indicative of hysteresis between abdomen markers and the internal motion of the heart. Methods: In 19 healthy volunteers, they determined the internal motion of the heart and diaphragm in the superior–inferior direction during free breathing using MRI navigators. A visual tracking system (VTS) synchronized with MRI acquisition tracked the anterior–posterior motions of external markers placed on the chest and abdomen. These data were employed to develop and test the Bouc–Wen model by inputting the VTS derived chest and abdomen motions into it and using the resulting output signals as surrogates for cardiac motion. The data of the volunteers were divided into training and testing sets. The training set was used to obtain initial values for the model parameters for all of the volunteers in the set, and for set members based on whether they were or were not classified as exhibiting hysteresis using a metric derived from the markers. These initial parameters were then employed with the testing set to estimate output signals. Pearson’s linear correlation coefficient between the abdomen, chest, average of chest and abdomen markers, and Bouc–Wen derived signals versus the true internal motion of the heart from MRI was used to judge the signals match to the heart motion. Results: The results show that the Bouc–Wen model generated signals demonstrated strong correlation with the heart motion. This correlation was slightly larger on average than that of the external surrogate signals derived from the abdomen marker, and average of the abdomen and chest markers, but was not statistically significantly different from them. Conclusions: The results suggest that the proposed model has the potential to be a unified framework for modeling hysteresis in respiratory motion in cardiac perfusion studies and beyond.

  20. Viene descritto un metodo analitico per la determinazione dei flussi di radon dal suolo partendo da misure di concentrazione del gas nello strato limite

    E-Print Network [OSTI]

    Curci, Gabriele

    possono modulare l'emissione di radon. A volte anche l'attività sismica può influenzare la concentrazione

  1. Foglio illustrativo del corso di Elettromagnetismo e Ottica

    E-Print Network [OSTI]

    Marrucci, Lorenzo

    ) gli esami di meccanica e termodinamica, di analisi matematica 1 e di geometria, anche se solo il primo

  2. Universit deg Centro di Serv

    E-Print Network [OSTI]

    Guidoni, Leonardo

    pre razione il num a e riducend etente (anch scritti ai cor e iscrizione a rso del propr enuto almen

  3. B A N D O D I C O N C O R S O PREMIO DI CULTURA "AURELIO MARCANTONI"

    E-Print Network [OSTI]

    Di Pillo, Gianni

    verranno, in nessun caso, prese in conside- razione le domande pervenute dopo il 31 ottobre 2012, anche se

  4. Amelia Rosselli: poesia e guerra

    E-Print Network [OSTI]

    Re, Lucia

    2007-01-01

    a dirigere tutte le sue energie verso tire il poesia, senzamol- tiplicava le proprie energie creative anche grazie sua

  5. Nuclide Imaging: Planar Scintigraphy, SPECT, PET

    E-Print Network [OSTI]

    Suel, Torsten

    Capture · Also known as Beta Plus decay ­ A proton changes to a neutron, a positron (positive electron) · A nucleus (which is unstable) changes from a higher energy state to a lower energy state through: energy of each photon 2 4 r AE I = #12;EL5823 Nuclear Imaging Yao Wang, Polytechnic U., Brooklyn 9

  6. Positron Emission Tomography (PET) and Positron Scanning

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformationJesseworkSURVEYI/OPerformancePi Day Pi DayPorterfield named ASTMPositive

  7. Caring for Pet Birds Seminar In May, Dr. Joao Brandao presented "Pet Birds: How

    E-Print Network [OSTI]

    Recognition Ceremony where faculty and House Officer Seminar Dr. Johnattan Arango will present "Gunshot Animal Surgery Resident mentored by Dr. Mark Rochat. Neurologist and Medical Educator to Speak David LeeRaps is an accounting specialist at the Oklahoma Animal Disease Diagnostic Laboratory. Originally from Stillwater

  8. Petroleum Technology (AS) Curriculum Guide Student Name: PS#

    E-Print Network [OSTI]

    Jiang, Huiqiang

    PET 0201 Petroleum & Natural Gas Chemistry PET 0203 Oil & Gas Gathering & Transportation PET 0204 Well

  9. Cytochrome b6 Arginine 214 of Synechococcus sp. PCC 7002, a Key Residue for Quinone-reductase Site Function and

    E-Print Network [OSTI]

    ­6). Four or five additional small subunits, PetG, PetL, PetM, PetN, and PetO (in chloroplasts) have also

  10. Renewable energy in commercial buildings

    E-Print Network [OSTI]

    Scarpa, Massimiliano; Schiavon, Stefano; Zecchin, Roberto

    2008-01-01

    termica - Energia solare fotovoltaica Si ritiene inoltre4.3. L’energia solare fotovoltaica Gli impianti solariAnche per la fonte solare fotovoltaica valgono le medesime

  11. POLITECNICO DI MILANO Corso di Laurea in Ingegneria Informatica

    E-Print Network [OSTI]

    Gatti, Nicola

    `o: non credo che questa tesi ti piacer`a come quella della triennale, ma fidati che anche questo `e stato

  12. Insularità: note sul rapporto fra gli scrittori siciliani e la loro terra

    E-Print Network [OSTI]

    Fatta, Ilaria

    2015-01-01

    vengono racchiusi in sintesi i mali e le profonde mancanzema anche di combattere i mali dai quali la regione secondoscrittore “denunciare” questi mali al fine di raggiungere,

  13. Dall' Italian Manner alla modernità liquida. Relazioni artistiche fra alcuni paesi arabo-mediterranei e l'Italia

    E-Print Network [OSTI]

    Corgnati, Martina

    2010-01-01

    analoghi anche per Siria, Iraq, Giordania, Egitto e altriarabo, dall’Algeria all’Iraq, residenti in larga maggioranzaSiria), Ali Al Jabiri (Iraq), Hassan Badawi (Libano),

  14. PET Imaging of Nucleoside Metabolism for Individualized Therapy

    E-Print Network [OSTI]

    Lee, Jason Thanh

    2012-01-01

    panel  of   human  ovarian  cancer  cell  lines.  Results  in human lymphoma and ovarian cancer cell lines reveal great4.3 lymphoma  and  ovarian  cancer  cell  lines   viii  

  15. Use of PET in the understanding of Addiction

    SciTech Connect (OSTI)

    Schlyer D. J.; Schlyer, D.J.

    2013-04-03

    The objective of this research is to understand the factors contributing to addiction in the human and to understand the effects of addiction on the brain.

  16. Process Engineering Thermodynamics (PET) RZ 424304 E (4 sp) 2015

    E-Print Network [OSTI]

    Zevenhoven, Ron

    0.5m×1.0m are placed 0.5 m apart, with temperatures T1 = 1000°C, T2 = 500°C, respectively the exergy loss due to the irreversibility of this process. 2. (SAKS04) Water of 20°C is cooled and frozen to ice at 0°C in a counter-current process with evaporating ammonia ­ see Figure. The minimum temperature

  17. PET And Bioluminescent Imaging Aid Evaluation Of Stem Cells'...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    interactive.snm.orgindex.cfm?PageID903&CFID27713770&CFTOKEN13840564 Submitted: Tuesday, December 4, 2007 - 12:00am...

  18. Polymorphous Domesticities: Pets, Bodies, and Desire in Four Modern Writers

    E-Print Network [OSTI]

    Schiesari, Juliana

    2012-01-01

    by what I called houses without animals” [l’étonnement, l’house reveals once again her closeness to the animal: “Robinanimal stories” are inex- plicably absent from the English translation of My Mother’s House.

  19. PET Studies of Phonetic Processing of Speech: Review, Replication, and

    E-Print Network [OSTI]

    Sereno, Martin

    condition of passive listening. Analysis was carried out by paired-image sub- traction, with MRI overlay of rhyme (as in the words "house" and "mouse," -which rhyme by virtue of their similar syllabic structure

  20. Sinking a Pet's Teeth into Energy Saving | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:Financing Tool FitsProjectDataSecretary Moniz'sSeparationNanowire Anodes for NextCarbon

  1. Integrated X-Ray Reflectivity Measurements for Elliptically Curved PET

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfate Reducing(Journal Article)lasers(JournalatBaBartheExpansion (Journal Article) |Report) |Crystals

  2. Integrated X-Ray Reflectivity Measurements for Elliptically Curved PET

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfate Reducing(Journal Article)lasers(JournalatBaBartheExpansion (Journal Article) |Report)

  3. Integrated X-ray Reflectivity Measurements for Elliptically Curved PET

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfate Reducing(Journal Article)lasers(JournalatBaBartheExpansion (Journal Article) |Report)Crystals

  4. I 'RADIOPHARNACEUTICALS IN PET, PROGRESS AND PROMISE F

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (JournalvivoHighHussein KhalilResearch &ENERGY I NFRASTRUCTURE - _-f

  5. Kinetic Effects of the Electrochemical Proton Gradient on Plastoquinone Reduction at the Qi Site of the Cytochrome

    E-Print Network [OSTI]

    subunits PetG, PetL, PetM and PetN (2, 4­5) have also been evidenced. Sequence comparisons have shown

  6. Conformational Changes in the Cytochrome b6 f Complex Induced by Inhibitor Binding*

    E-Print Network [OSTI]

    subunits mentioned above, the b6 f complex comprises four smaller subunits, PetG, PetL, PetM, and PetN (13

  7. Biochemical and Spectroscopic Characterization of the Covalent Binding of Heme to Cytochrome b6

    E-Print Network [OSTI]

    , subunit IV, Rieske protein, and four small subunits (PetG, PetL, PetM, and PetN) comprising a single

  8. Per una dinamica nei fondamenti

    E-Print Network [OSTI]

    Sambin, Giovanni

    ). Credo di introdurre delle idee davvero nuove, anche con rilevanza filosofica generale, e non solo per la non credo sia facile. Oppure `e da espandere qualche parte di Alla ricerca. . . fino a farlo diventare

  9. Sismotettonica dell'Italia nord-orientale e possibile comparazione con gli Appennini

    E-Print Network [OSTI]

    stati più profondi, tra i 5 e 10 km. D'altra parte, nel terremoto dell'Irpinia del 1980, nell riconosciuto anche per il terremoto Umbro-Marchigiano del 1997. In altre parole la sismicità sembra migrare dai

  10. UNIVERSIT DI BRESCIA FACOLT DI INGEGNERIA

    E-Print Network [OSTI]

    Cassinis, Riccardo

    a permettere la localizzazione a 360 gradi del robot da parte delle videocamere, anche di risparmiare energia studiato appositamente per essere immune alle interferenze dovute alla luce solare in spazi aperti. Al

  11. AREA PATRIMONIO E SERVIZI ECONOMAll

    E-Print Network [OSTI]

    Di Pillo, Gianni

    agli studenti Internazionalizzazione Contabilità, finanza e controllo di gestione UffICio Gare'anno in corso, era possibile ad opera di un solo R.U.P., anche a fronte di più Centri di Costo afferenti alla

  12. AREA PATRIMONIO E SERVIZI ECONOMAU

    E-Print Network [OSTI]

    Guidoni, Leonardo

    studio Servizi agli studenti Internazionalizzazione Contabilità, finanza e controllo di gestione Tel(+39'anno in corso, era possibile ad opera di un solo R.U.P., anche a fronte di più Centri di Costo afferenti alla

  13. Leon Battista Alberti e la parodia sacra: la predica di Ecatonfilea

    E-Print Network [OSTI]

    Largaiolli, Matteo

    2014-01-01

    dimostrano anche il suo interesse per il riso e l’ironia: un riso che di solito non ha un intento sovversivoGarin, “Il pensiero,” 509. Sul riso cfr. Rosario Contarino,

  14. VERSO L'ANALISI STATICA DEGLI ANSWER SET TOWARDS STATIC ANALYSIS OF ANSWER SET

    E-Print Network [OSTI]

    Costantini, Stefania

    Stefania Costantini #12;Abstract In questo lavoro viene proposto un metodo di analisi sta- tica per l Gelfond e Lifschitz (chiamata anche seman- tica dei "modelli stabili"). Il metodo si basa sui seguenti

  15. Repertorio delle ricerche di eccellenza Catalogue of Selected Research Results

    E-Print Network [OSTI]

    Di Pillo, Gianni

    'Istituto Pasteur - Fondazione Cenci Bolognetti e la Kimbo Café do Brasil che hanno finanziato insieme al nostro globale che investe anche le università, interrogate sul loro ruolo e sul loro futuro. Siamo tutti quindi

  16. Fortuna e politica all’origine della filosofia italiana

    E-Print Network [OSTI]

    Esposito, Roberto

    2011-01-01

    anch’essa come una scelta vitale. Come egli stesso scrive inessa parte del medesimo flusso vitale che abbraccia uomini,ad intendere che il principio vitale non consiste ne gli

  17. Il colore della statualità. Leggi suntuarie, codici estetici e modelli culturali delle élites nella Napoli della prima Età moderna

    E-Print Network [OSTI]

    Scognamiglio, Sonia

    2012-01-01

    Laterza 1992); Giuliana Vitale, Modelli culturali nobiliariBari: Laterza, 1992. Vitale, Giuliana, Élite burocratica e177-257. Anche Giuliana Vitale, che ha studiato l’élite del

  18. Photo of the Week: Pre-PET Headgear | Department of Energy

    Energy Savers [EERE]

    auditorium at 2 a.m. EDT July 4 and waited for the latest announcement regarding the Higgs boson. When CERN Director-General Rolf-Dieter Heuer said the words - "I think we have it"...

  19. Expanding the capabilities of microfluidic systems for positron emission tomography (PET) tracer synthesis and analysis

    E-Print Network [OSTI]

    Ma, Xiaoxiao

    2014-01-01

    was observed, indicating gas leakage through the DMSO valve.recorded as the leakage pressure of the valve. The range ofof 4.4 cm. The leakage pressure of DMSO valves with this

  20. Future work: This section is one of the repeat units in the PET structure.

    E-Print Network [OSTI]

    if propylene carbonate (PCA) (see figure 2) could be used as a solvent. PCA is safer than most of the solvents in a class of polymers called polyesters. They are called polyesters because they are long molecules and analysis of our experimental, scientific research were sufficient to conclude that propylene carbonate (PCA

  1. Very fast doped LaBr.sub.3 scintillators and time-of-flight PET

    DOE Patents [OSTI]

    Shah, Kanai S.

    2006-10-31

    The present invention concerns very fast scintillator materials capable of resolving the position of an annihilation event within a portion of a human body cross-section. In one embodiment, the scintillator material comprises LaBr.sub.3 doped with cerium. Particular attention is drawn to LaBr.sub.3 doped with a quantity of Ce that is chosen for improving the timing properties, in particular the rise time and resultant timing resolution of the scintillator, and locational capabilities of the scintillator.

  2. Anti-PSCA minibody for immunoPET imaging of prostate cancer in preclinical models

    E-Print Network [OSTI]

    Knowles, Scott Matthew

    2013-01-01

    treated with prostatectomy, brachytherapy, or no definitiveBeam Radiation Therapy, or Brachytherapy in Men Withoutradiation, and prostate brachytherapy all have significant

  3. The effect of pet ownership/attachment on the stress level of multiple sclerosis patients 

    E-Print Network [OSTI]

    Loven, Ashley Marie

    2005-11-01

    Multiple Sclerosis (MS) is the most common demyelinating disease affecting the central nervous system. Over 80% of MS patients are in the relapsing remitting stage. Symptoms range from fever, fatigue, emotional distress, tingling, numbness, optic...

  4. Search WEB SEARCH Science Video Weather News Space & Astronomy Animals & Pets Dinosaurs & Fossils Biotech Energy Environment

    E-Print Network [OSTI]

    Weiss, Benjamin P.

    Providing You With Enough Tax Savings? Meteorites for Sale Meteorites for Education, Science and Collectors and etched slices from around the world at reasonable prices to discriminating collectors, museums of the solar system, when dust and rubble in a disk around the sun collided and stuck together to form ever

  5. DEVELOPMENT OF A DUAL MODALITY TOMOGRAPHIC IMAGING SYSTEM FOR BIOLUMINESCENCE AND PET

    SciTech Connect (OSTI)

    CHATZIIOANNOU, ARION

    2011-12-21

    The goal of this proposal was to develop a new hybrid imaging modality capable to simultaneously image optical bioluminescence signals, as well as radionuclide emissions from the annihilation of positrons originating from molecular imaging probes in preclinical mouse models. This new technology enables the simultaneous in-vivo measurements of both emissions that could be produced from a single or a combination of two different biomarkers. It also facilitates establishing the physical limitations of bioluminescence imaging, its tomographic and spectral image reconstruction potential and the quantification of bioluminescence signals.

  6. Development of the Pixelated Photon Detector Using Silicon on Insulator Technology for TOF-PET

    E-Print Network [OSTI]

    Koyama, Akihiro; Takahashi, Hiroyuki; Orita, Tadashi; Arai, Yasuo; Kurachi, Ikuo; Miyoshi, Toshinobu; Nio, Daisuke; Hamasaki, Ryutaro

    2015-01-01

    To measure light emission pattern in scintillator, higher sensitivity and faster response are required to photo detector. Such as single photon avalanche diode (SPAD), conventional pixelated photo detector is operated at Geiger avalanche multiplication. However higher gain of SPAD seems very attractive, photon detection efficiency per unit area is low. This weak point is mainly caused by Geiger avalanche mechanism. To overcome these difficulties, we designed Pixelated Linear Avalanche Integration Detector using Silicon on Insulator technology (SOI-Plaid). To avoid dark count noise and dead time comes from quench circuit, we are planning to use APD in linear multiplication mode. SOI technology enables laminating readout circuit and APD layer, and high-speed and low-noise signal reading regardless smaller gain of linear APD. This study shows design of linear APD by using SOI fabrication process. We designed test element group (TEG) of linear APD and inspected optimal structure of linear APD.

  7. Robotic Pets in the Lives of Preschool Children Peter H. Kahn, Jr.1

    E-Print Network [OSTI]

    Kahn, Peter H.

    into physical artifacts ­ personal robots represent a new genre for human-computer interaction. Building. Perez-Granados3 , and Nathan G. Freier2 1 Department of Psychology University of Washington Seattle, WA. Categories & Subject Descriptors: H.1.2 [Models and Principles]: User/Machine Systems ­ Software psychology

  8. Chemical compounds and toxicological assessments of drinking water stored in polyethylene terephthalate (PET)

    E-Print Network [OSTI]

    Short, Daniel

    Chemical compounds and toxicological assessments of drinking water stored in polyethyleneMS, gas chromatographyemass spectrometry; HDPE, high density polyethylene; HULYs, human blood lymphocytes

  9. COLLEGE Of EnGinEErinG Dean: PEtEr E. CrOuCh

    E-Print Network [OSTI]

    Reed, Nancy E.

    : mechanical engineering, electrical engineering, and civil and environmental engineering and an organized complex needs of our society. 1 #12;The Department of Civil & Environmental Engineering offers the BS- ment, environmental and water resources engineering, geotechnical engineering, structural engineering

  10. Age Differences in Behavior and PET Activation Reveal Differences in Interference

    E-Print Network [OSTI]

    Jonides, John

    in Verbal Working Memory John Jonides, Christina Marshuetz, Edward E. Smith, Patricia A. Reuter, Petrides, & Smith, 1985; Roberts, Hager, & Hernon, 1994; West, 1996; Smith, Jonides, Mar- shuetz, & Koeppe

  11. Effect of micro-patterning on bacterial adhesion on PET (polyethylene terephthalate) surface

    E-Print Network [OSTI]

    Wang, Liyun; Chen, Wei; Terentjev, Eugene

    2014-12-16

    medical devices and food processing facilities 4 are prone to infections caused by the attached microbes, and eventually - biofilms, leading to a direct threat to 5 health and food contamination.3-6 Hence, a host of biological and chemical strategies... -Tasciuc DA, et al. Effect of micro-and nanoscale topography on the adhesion of 6 bacterial cells to solid surfaces. Appl Environ Microb 2013;79:2703-12. 7 4. Antoci Jr V, Adams CS, Parvizi J, et al. The inhibition of Staphylococcus epidermidis biofilm...

  12. Improved Production and Separation Technologies for Non-standard PET Radionuclides

    SciTech Connect (OSTI)

    Welch, Michael J. [Washington University, St. Louis, MO] [Washington University, St. Louis, MO (United States); Lapi, Suzanne [Washington University, St. Louis, MO] [Washington University, St. Louis, MO (United States)

    2012-12-01

    Brief summary of activity issues, concerns, successes: Project 1 is completed. We have optimized plating parameters with the new target bodies and slanted target plating system. The target station has been mounted on the end of the beamline, service lines have been nstalled to allow for helium and water cooling. We have routinely produced copper-64 using the new slanted target system in conjunction with our automated system. In project 2, we successfully fabricated and tested microfluidic extraction devices made out of two organic solvent-resistant polymers, thiolene and SIFEL. Initially, we developed analytical and computational models to describe the extraction process, and used the model to design the microfluidic devices. Then we optimized the microfabrication procedures to manufacture microreactors, followed by optimization of the operational parameters to obtain a stable aqueous-organic interface, which is critical for efficient extraction. When we tested the thiolene devices for extraction of copper-64, we observed very low extraction efficiencies (less than 5%) due to adhesion of copper to thiolene. However, we observed very high extraction efficiencies with SIFEL devices (greater than 95%), which are due to the high interfacial area for extraction and shorter diffusion lengths.

  13. Triazine-Based Tool Box for Developing Peptidic PET Imaging Probes: Syntheses, Microfluidic Radiolabeling, and Structure-

    E-Print Network [OSTI]

    Kenis, Paul J. A.

    , 510 South Kingshighway Boulevard, St. Louis, Missouri 63110, United States Department of Radiation.6-fold enhancement of binding affinity compared to DOTA-TZ-cyclo(RGDfK) 14 conjugate on U87MG human there was no clear bivalency effect for DOTA-TZ-BisRGD in vivo, which needs further experiments to address

  14. How Much Water is Enough? Using PET to Develop Water Budgets for Residential landscapes 

    E-Print Network [OSTI]

    White, R.; Havalak, R.; Nations, J.; Thomas, J.; Chalmers, D.; Dewey, D.

    2004-01-01

    Conserving and reducing the amount of water used for landscape irrigation continues to be a major issue for municipalities throughout Texas and the nation. Landscape irrigation increases dramatically during summer months and contributes...

  15. Expanding the capabilities of microfluidic systems for positron emission tomography (PET) tracer synthesis and analysis

    E-Print Network [OSTI]

    Ma, Xiaoxiao

    2014-01-01

    electrowetting,” J. Microelectromechanical Syst. , vol. 9,circuits,” J. Microelectromechanical Syst. , vol. 12, no. 1,micropropulsion,” J. Microelectromechanical Syst. , vol. 13,

  16. A LSO scintillator array for a PET detector module with depth of interaction measurement

    E-Print Network [OSTI]

    Huber, J.S.; Moses, W.W.; Andreaco, M.S.; Petterson, O.

    2000-01-01

    Schweitzer, “Cerium-doped lutetium oxyorthosilicate: a fast,material. Our production lutetium oxyorthosilicate (LSO)

  17. Pet Name _________________ Species _________________ Breed _________________ Color ___________ Date of Birth/Age _______________ Weight _________________ Gender: M MC F FS

    E-Print Network [OSTI]

    Langerhans, Brian

    a history of: Loose stool, diarrhea or vomiting Respiratory illness ­ nasal discharge, coughing, sneezing

  18. The need for clinical quantification of combined PET/MRI data in pediatric epilepsy

    E-Print Network [OSTI]

    Hua, Jing

    of Medicine, Detroit, MI, USA b Department of Radiology, Wayne State University School of Medicine, Detroit, MI, USA c Department of Computer Science, Wayne State University School of Medicine, Detroit, MI, USA

  19. Combining MRI with PET for partial volume correction improves image-derived input functions in mice

    E-Print Network [OSTI]

    Evans, Eleanor; Buonincontri, Guido; Izquierdo, David; Methner, Carmen; Hawkes, Rob C.; Ansorge, Richard E.; Krieg, Thomas; Carpenter, T. Adrian; Sawiak, Stephen J.

    2015-06-05

    , CB2 0QQ (e-mail: gb396@cam.ac.uk). D. Izquierdo is with the Athinoula A. Martinos Center for Biomedical Imaging, 149 Thirteenth Street, Suite 2301, Charlestown, MA, 02129 (e-mail: davidizq@nmr.mgh.harvard.edu). C. Methner was with the Department... (DOUBLE-CLICK HERE TO EDIT) Am. J. Roentgenol., 195 (2), pp. 310–320, 2010. [4] P. Dupont...

  20. Precise Measurement of Strontium-82 Radioactivity in the Sr-Rb PET

    Office of Science (SC) Website

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effectWorkingLosThe23-24, 2011 HighMayOctober

  1. 6.19 MicroPET Enhances Studies of Small Animals

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservationBio-InspiredAtmosphericdevicesPPONeApril351APPLICATION OF kV Spare|LiMessage6-1 6.08

  2. PET: An Emerging Tool in the Fight Against Cancer |GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass mapSpeeding access toOctoberConsumptionPoweredE ContractMarchAn Embedded

  3. Monte Carlo simulation of PET and SPECT imaging of {sup 90}Y (Journal

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfate Reducing(JournalspectroscopyReport)Fermentativea Stochastic Galerkin Method. (Conference)

  4. The Dog Days of Summer - Capitalizing on the Pet Market | Department of

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LIST OF APPLICABLEStatutory Authority J-I-12 GeV CEBAFThe U.S.EvaluationAgreement

  5. Photo of the Week: Pre-PET Headgear | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirley Ann JacksonDepartment ofOffice|inWest Kentucky RegionalAt Argonne NationalDepartment ofUCOnIn

  6. Performing Arts Management 306 Hinkley Center Provo, UT 84602-8500 (801) 422-3576 Fax: (801) 422-0546 Email: perform@byu.edu

    E-Print Network [OSTI]

    Martinez, Tony R.

    by BYU) Phone Number Single or Dble beds 1. Married Single Male Female Couple Any Pets? Yes No 2. Married Single Male Female Couple Any Pets? Yes No 3. Married Single Male Female Couple Any Pets? Yes No 4. Married Single Male Female Couple Any Pets? Yes No 5. Married Single Male Female Couple Any Pets? Yes No 6

  7. PALS investigations of free volumes thermal expansion of J-PET plastic scintillator synthesized in polystyrene matrix

    E-Print Network [OSTI]

    A. Wieczorek; B. Zgardzi?ska; B. Jasi?ska; M. Gorgol; T. Bednarski; P. Bia?as; E. Czerwi?ski; A. Gajos; D. Kami?ska; ?. Kap?on; A. Kochanowski; G. Korcyl; P. Kowalski; T. Kozik; W. Krzemie?; E. Kubicz; S. Nied?wiecki; M. Pa?ka; L. Raczy?ski; Z. Rudy; O. Rundel; N. G. Sharma; M. Silarski; A. S?omski; A. Strzelecki; W. Wi?licki; M. Zieli?ski; P. Moskal

    2015-08-27

    The polystyrene dopped with 2,5-diphenyloxazole as a primary fluor and 2-(4-styrylphenyl)benzoxazole as a wavelength shifter, prepared as a plastic scintillator was investigated using positronium probe in wide range of temperatures from 123 to 423 K. Three structural transitions at 260 K, 283 K and 370 K were found in the material. In the o-Ps intensity dependence on temperature, the significant hysteresis is observed. Heated to 370 K, the material exhibits the o-Ps intensity variations in time.

  8. PALS investigations of free volumes thermal expansion of J-PET plastic scintillator synthesized in polystyrene matrix

    E-Print Network [OSTI]

    Wieczorek, A; Jasi?ska, B; Gorgol, M; Bednarski, T; Bia?as, P; Czerwi?ski, E; Gajos, A; Kami?ska, D; Kap?on, ?; Kochanowski, A; Korcyl, G; Kowalski, P; Kozik, T; Krzemie?, W; Kubicz, E; Nied?wiecki, S; Pa?ka, M; Raczy?ski, L; Rudy, Z; Rundel, O; Sharma, N G; Silarski, M; S?omski, A; Strzelecki, A; Wi?licki, W; Zieli?ski, M; Moskal, P

    2015-01-01

    The polystyrene dopped with 2,5-diphenyloxazole as a primary fluor and 2-(4-styrylphenyl)benzoxazole as a wavelength shifter, prepared as a plastic scintillator was investigated using positronium probe in wide range of temperatures from 123 to 423 K. Three structural transitions at 260 K, 283 K and 370 K were found in the material. In the o-Ps intensity dependence on temperature, the significant hysteresis is observed. Heated to 370 K, the material exhibits the o-Ps intensity variations in time.

  9. ELIXYS - a fully automated, three-reactor high-pressure radiosynthesizer for development and routine production of diverse PET tracers

    E-Print Network [OSTI]

    2013-01-01

    against various positions on a PTFE-coated silicone gasketpoly- tetrafluoroethylene (PTFE)-coated silicone gasket (

  10. Analysis of the mouse embryonic stem cell regulatory networks obtained by ChIP-chip and ChIP-PET

    E-Print Network [OSTI]

    Mathur, Divya

    Background: Genome-wide approaches have begun to reveal the transcriptional networks responsible for pluripotency in embryonic stem (ES) cells. Chromatin Immunoprecipitation (ChIP) followed either by hybridization to a ...

  11. 18F-FDG PET and Perfusion SPECT in the Diagnosis of Alzheimer and Lewy Body Dementias

    E-Print Network [OSTI]

    O’Brien, John T.; Firbank, Michael J.; Davison, Christopher; Barnett, Nicky; Bamford, Claire; Donaldson, Cam; Olsen, Kirsty; Herholz, Karl; Williams, David; Lloyd, Jim

    2014-11-05

    each group. SPECT head scans were acquired using a Siemens Symbia S dual-detector g camera, starting 30 min after the intravenous administration of 500 MBq of 99mTc-HMPAO. One hundred twenty 25-s planar views were obtained on a 128 · 128 matrix, zoom 1... University Hospitals NHS Foundation Trust and the University of Cambridge. Michael J. Firbank reports grants from the National Institute for Health Research. Karl Herholz reports grants and personal fees from Lilly/Avid Radiopharmaceuticals; personal fees...

  12. Lu1-xI3:Cex--A Scintillator for gamma ray spectroscopy and time-of-flight PET

    DOE Patents [OSTI]

    Shah, Kanai S. (Newton, MA)

    2009-03-17

    The present invention concerns very fast scintillator materials comprising lutetium iodide doped with Cerium Lu.sub.1-xI.sub.3:Ce.sub.x; LuI.sub.3:Ce). The LuI.sub.3 scintillator material has surprisingly good characteristics including high light output, high gamma ray stopping efficiency, fast response, low cost, good proportionality, and minimal afterglow that the material is useful for gamma ray spectroscopy, medical imaging, nuclear and high energy physics research, diffraction, non-destructive testing, nuclear treaty verification and safeguards, and geological exploration. The timing resolution of the scintillators of the present invention provide compositions capable of resolving the position of an annihilation event within a portion of a human body cross-section.

  13. ELIXYS - a fully automated, three-reactor high-pressure radiosynthesizer for development and routine production of diverse PET tracers

    E-Print Network [OSTI]

    2013-01-01

    18 F]fluoride) Optional cartridge (e.g. , QMA) Additionproducts to purification cartridges, subsequent cassettes,addition port position 1 Cartridge waste Stopcock valves

  14. The neural substrates of script knowledge deficits as revealed by a PET study in Huntington's Philippe Allain

    E-Print Network [OSTI]

    Boyer, Edmond

    CEA Service hospitalier Frédéric Joliot, DRM, Orsay, France f Sint Maartenskliniek Research Neurologie, Centre Hospitalier Universitaire, 4 rue Larrey, 49033 Angers Cedex 01. Telephone: +33 (0)2 41 35 in the management of script event knowledge required in planning behavior. Methods: This study was designated to map

  15. Abstract Factor analysis has been pursued as a means to decompose dynamic cardiac PET images into different tissue types

    E-Print Network [OSTI]

    Adler, Andy

    using simulated data and on a canine model with different 82 Rb infusion profiles. Biasing of factors scans with varying 82 Rb (150 MBq) infusion durations (15, 30, 60, 120, 240, 240, 120, 60, 30, 15

  16. Abstract--The new high spatial resolution PET detectors for small animal and breast imaging have been developed. In these

    E-Print Network [OSTI]

    Thompson, Chris

    (Y) anode wires, this method reduces the number of processing signals by a factor of three. Every chain, we still have to process 4 (X- , X+ , Y- , and Y+ ) × 16 (PMTs) individual position signals+ , Y-- , and Y+ ) outputs have been developed to further simplify the position processing. The front

  17. AUTOCOSTRUIRSI UNA STAMPANTE 3D Da Dove Iniziare?

    E-Print Network [OSTI]

    AUTOCOSTRUIRSI UNA STAMPANTE 3D #12;Da Dove Iniziare? Quale sarà la 3D Printer più adatta al mio stampante 3D partendo da zero? · E' meglio che acquisto un kit di montaggio anche se più caro? E' STATA UNA progetto sarà la costruzione di una stampante 3D. ATTENZIONE: Il fab lab non ti fa il lavoro ma ti supporta

  18. Laurea I livello in Chimica e Chimica Industriale Istituzioni di Matematica II (2007)

    E-Print Network [OSTI]

    Fassò, Francesco

    2007-01-01

    Laurea I livello in Chimica e Chimica Industriale Istituzioni di Matematica II (2007) Settimana 26/2 ­ 2/3 Per il materiale svolto a lezione vedere anche l'Adams alle pagine 29-30, 35-39, 43-44. Esercizi

  19. In questo libretto sono illustrati i quesiti proposti nella seconda edizione del Kangourou dell'Informatica, fase eliminatoria, che si e svolta il 10 marzo 2010. Il software con il quale i quesiti sono stati presentati ai concorrenti

    E-Print Network [OSTI]

    Monga, Mattia

    Kangourou dell'Informatica, fase eliminatoria, che si e svolta il 10 marzo 2010. Il software con il quale i'ambito dell'informatica; vengono anche individuate delle parole chiave che possono essere utili per ricerche promuovere l'informatica come disciplina scienti#12;ca. Violetta Lonati Mattia Monga Anna Morpurgo Lorenzo

  20. Curriculum in italiano IMPIEGHI IN UNIVERSITA'

    E-Print Network [OSTI]

    Lattanzi, Emanuele

    ' del Comune di Pesaro". Tale collaborazione ha portato all'installazione presso la stazione sismica alla sequenza sismica di Colfiorito del 1997/98. Dal 2003 si è anche occupato della modellazione dei campi di sforzo generati dalle dislocazioni della sequenza sismica di Colfiorito (1997) e dagli eventi

  1. STAG UK Newsletter Issue 26 

    E-Print Network [OSTI]

    1977-01-01

    'HISES WWJCLIFFE TlllANCH - John Hind, 14 ELngham Rd., l1adcliffe-on-'l'rent, Notts, NG12 2FY. '!'ho club for those with a zany sense of humour. S'!'AR TREK HfPOHl\\'iATION G!lOUP - Ross Carter, 29 Castle Hoad, Southsea, Portsmouth. O~rrCOR.i!1 - ~'racy Cooke, 67...

  2. Proposte progetti per PSC a.a. 2007-08 Tutti i progetti richiedono una ricerca bibliografica che riguarda i lavori inerenti alle

    E-Print Network [OSTI]

    Schenato, Luca

    molto utile in questo senso e' Google Scholar http://scholar.google.it/, un motore di ricerca per articoli presenti in rete. Il vantaggio e' che questo motore trova anche articoli che citano un particolare radice in base ai vari livelli di energia delle batterie e del grafo di connettivita'. Nel laboratorio

  3. INDAGINE 1990-1993 Nell'analisi sono prese in considerazione solo le 96 persone che al momento della compilazione

    E-Print Network [OSTI]

    Rogantin, Maria Piera

    svolto (2 modalità: si, no) #12;Interpretazione dei risultati per asse PRIMO ASSE: da un lato si'università, potendolo - ha scelto la tesi anche in prospettiva occupazionale Questo asse complessivamente discrimina un poco fiducioso nei propri mezzi, incapace di scegliere e timoroso delle novità. #12;SECONDO ASSE: da un

  4. T'

    Office of Legacy Management (LM)

    j: ;;I : T' j-jE: i t 1 ,iu" I;ts'J-F.; +X'l'W 20, ,57 I::anch T;3 cl:l:i xi ,.&A O.Cfice J su T>J...

  5. CONVERSIONE DEL PROPRIO CATALOGO IN PADUA@THESIS Padua@thesis (http://tesi.cab.unipd.it/) oltre ad essere un archivio che rende disponibili a testo

    E-Print Network [OSTI]

    Pettenella, Davide

    1 CONVERSIONE DEL PROPRIO CATALOGO IN PADUA@THESIS Padua@thesis (http://tesi.cab.unipd.it/) oltre ad essere un archivio che rende disponibili a testo pieno le tesi depositate ha anche funzione di catalogo delle tesi a stampa, consultabili presso le biblioteche, di cui fornisce i dati catalografici. Se

  6. Allegato A) SERVIZI WEB

    E-Print Network [OSTI]

    Guidoni, Leonardo

    Allegato A) SERVIZI WEB Dottorato di ricerca Modalità per la stampa del modulo di pagamento e della bisogna: 1. connettersi alla pagina web: http://www.uniroma1.it/didattica/sportelli/infostud (sulla stessa pagina web sono illustrati anche i requisiti tecnici necessari per effettuare correttamente le operazioni

  7. Chloroplast genome sequence of the moss Tortula ruralis: gene content, polymorphism, and structural arrangement relative to other green plant chloroplast genomes.

    E-Print Network [OSTI]

    2010-01-01

    chloroplast genome lacks petN, a gene found in all knownlist reveals the absence of petN, a gene that is found inchloroplast genome lacks the petN gene because the protein

  8. Effect of nano-fibers on the stress-strain behavior of semi-crystalline poly(ethylene terephthalate) at different strain rates

    E-Print Network [OSTI]

    Cohen, Ellann

    2008-01-01

    Uniaxial compression tests were performed on amorphous poly(ethylene terephthalate) (PET), amorphous poly(ethylene terephthalate)- glycol (PETG), semi-crystalline PET, and semicrystalline PET with various amounts of ...

  9. Expert Panel: Forecast Future Demand for Medical Isotopes | Department...

    Broader source: Energy.gov (indexed) [DOE]

    18F-FDG PET has been studied for detecting and staging recurrent ovarian cancer. Potential savings were estimated at 8500 per patient with PET (J Nucl Med...

  10. Numerical studies on two-way coupled fluid flow and geomechanics in hydrate deposits

    E-Print Network [OSTI]

    Kim, J.

    2014-01-01

    A. 2008. Modeling of Geomechanics in Naturally Fracturedcoupling porous flow and geomechanics. Soc. Pet. Eng. J. 11(a reservoir simulator and a geomechanics module. Soc. Pet.

  11. Effect of optically modified polyethylene terephthalate fiber socks on chronic foot pain

    E-Print Network [OSTI]

    York, Robyn MB; Gordon, Ian L

    2009-01-01

    of optically modified polyethylene terephthalate fiber sockswhether socks made from polyethylene terephthalate (PET)

  12. META-COMPILING TEXT GRAMMARS AS A MODEL FOR HUMAN BEHAVIOR

    E-Print Network [OSTI]

    in Germany and Holland, includes work such I as that of van Dijk, Ihwe, Pet~fi and Rieser l(1972), Pet6fi and Rieser (1973), Pet~fi (1973), van Dijk (1973), and van Dijk and Pet6fi (1974). The underlying motivation

  13. IEEE TRANSACTIONS ON MEDICAL IMAGING, VOL. 24, NO. 8, AUGUST 2005 1053 A Method for Determination of the Timing Stability

    E-Print Network [OSTI]

    Thompson, Chris

    POSITRON emission tomography (PET) scanners using lutetium oxy-orthosilicate (LSO) crystals should have of the Timing Stability of PET Scanners Christopher J. Thompson*, Member, IEEE, and Andrew L. Goertzen Abstract--We report on the timing resolution and stability of the MicroPET R4 PET scanner. Its detectors have energy

  14. OSU Human Resources, 106 Whitehurst, Stillwater, Oklahoma 74078 -(405) 744-5449 http://hr.okstate.edu September 2013 What's Inside

    E-Print Network [OSTI]

    , wearing her official Pistol Pete Pet Therapy vest! OCTOBER IS ANNUAL BENEFITS ENROLLMENT MONTH Annual

  15. Title: Research Associate III, Advanced Veterinary Diagnostic Imaging Research Employment type: Administrative Professional

    E-Print Network [OSTI]

    Stephens, Graeme L.

    and oversee CT, PET/CT calendar of use Perform complex image post-processing, analyze CT, PET/CT images Professional position. Overall nature of the position is to provide the lead role in the technological aspects of computed tomography and PET/CT. Responsibilities will include conducting CT and PET/CT studies

  16. Universit`a degli Studi di Bologna -Dipartimento di Matematica Master di II livello in Matematica per le Applicazioni

    E-Print Network [OSTI]

    Achilles, Rüdiger

    sull'asse z1. Allora il braccio 2 ruota nel piano (x1, y1). Il secondo sistema di coordinate (x2, y2, z2) ha anche l'origine nel primo giunto con l'asse x2 in direzione del braccio 2 e l'asse y2 nel piano (x1, y1). Il terzo sistema di coordi- nate (x3, y3, z3) con l'origine nel giunto 2 ha l'asse x3

  17. COMPITO di LOGICA MATEMATICA 19 luglio 2010

    E-Print Network [OSTI]

    Valentini, Silvio

    semantica visto che in ogni algebra di Boole x = x per ogni elemento x. `E tuttavia possibile fornire anche, a b a, a b, b (a b) 3 #12;Esercizio 4 Sia B una algebra di Boole. 1. Dimostrare che per ogni x, y B Heyting? 3. Dedurne che in ogni algebra di Boole, se x y allora c'`e un filtro proprio che contiene x e

  18. A pilot study of the novel J-PET plastic scintillator with 2-(4-styrylphenyl)benzoxazole as a wavelength shifter

    E-Print Network [OSTI]

    Wieczorek, A; Nied?wiecki, Sz; Bednarski, T; Bia?as, P; Czerwi?ski, E; Danel, A; Gajos, A; Gruntowski, A; Kami?ska, D; Kap?on, ?; Kochanowski, A; Korcyl, G; Kowal, J; Kowalski, P; Kozik, T; Krzemie?, W; Kubicz, E; Molenda, M; Pa?ka, M; Raczy?ski, L; Rudy, Z; Rundel, O; Salabura, P; Sharma, N G; Silarski, M; S?omski, A; Smyrski, J; Strzelecki, A; Uchacz, T; Wi?licki, W; Zieli?ski, M; Zo?, N

    2015-01-01

    For the first time a molecule of 2-(4-styrylphenyl)benzoxazole containing benzoxazole and stilbene groups is applied as a scintillator dopant acting as a wavelength shifter. In this article a light yield of the plastic scintillator, prepared from styrene doped with 2 wt% of 2,5-diphenylbenzoxazole and 0.03 wt% of 2-(4-styrylphenyl)benzoxazole, is determined to be as large as 60% $\\pm$ 2% of the anthracene light output. There is a potential to improve this value in the future by the optimization of the additives concentrations.

  19. 236 BULLETIN OF THE UNITED STATES FISH COMMISSION. THE PEtQTOIQA A N D PEZOTQPIEYTEB UOJBXDEREQ A B T X E E PRI-

    E-Print Network [OSTI]

    the minute living OF- ganisms out of the water which is passed through the mouth in respi- ration; tho with a brush. Jn a short time the Cypris iniglit be seeii lying at the bottooi of the vessel, the valves

  20. Final Report for "Boron and Tin in Nuclear Medicien: The Development of Reactive Solid-State Reagents for PET and SPECT

    SciTech Connect (OSTI)

    George W. Kabalka

    2006-01-13

    The research program was directed at the use of functionalized organometallic reagents that would rapidly react with radiolabeled agents generated by a medical cyclotron or reactor. The radioisotopes included fluorine-18, oxgygen-15, nitrogen-13, carbon-11 and iodine-123; all short lived nuclides of importantce in nuclear medicine imaging studies utilizing emission tomography techniques. The early studies led to the development of extensive new isotope incorporation chemistry. These studies validated the feasibility of using reactive intermediates, such as the organoboranes, and acted as a catalyst for others to investigate organometallic agents based on mercury, tin, and silicon. A large number of radiolabeling techniques and radiopharmaceuticals were developed. These included agents for use in oncology, neurology, and metabolism. The research resulted in the generation of one hundred and one journal articles, eighty seven refereed published abstracts and forty one invited lectures. Thirteen postdoctoral students, fourteen graduate students, and twenty eight undergraduate students were trained in the scientific aspects of nuclear medicine imaging under the asupices of this grant.

  1. 25 December 2006, Don L. Anderson If someone points out to you that your pet theory of the universe is in

    E-Print Network [OSTI]

    Garnero, Ed

    . If the intrinsic den- sity of D is as little as 1% higher than the rest of the mantle, it will be permanently for it but to collapse in deepest hu- miliation." Sir Arthur Stanley Eddington, The nature of the physical world (1915 proposed to emanate from the tops of superplumes, rather from D. We have also been told that lack of clear

  2. A pilot study of the novel J-PET plastic scintillator with 2-(4-styrylphenyl)benzoxazole as a wavelength shifter

    E-Print Network [OSTI]

    A. Wieczorek; P. Moskal; Sz. Nied?wiecki; T. Bednarski; P. Bia?as; E. Czerwi?ski; A. Danel; A. Gajos; A. Gruntowski; D. Kami?ska; ?. Kap?on; A. Kochanowski; G. Korcyl; J. Kowal; P. Kowalski; T. Kozik; W. Krzemie?; E. Kubicz; M. Molenda; M. Pa?ka; L. Raczy?ski; Z. Rudy; O. Rundel; P. Salabura; N. G. Sharma; M. Silarski; A. S?omski; J. Smyrski; A. Strzelecki; T. Uchacz; W. Wi?licki; M. Zieli?ski; N. Zo?

    2015-07-04

    For the first time a molecule of 2-(4-styrylphenyl)benzoxazole containing benzoxazole and stilbene groups is applied as a scintillator dopant acting as a wavelength shifter. In this article a light yield of the plastic scintillator, prepared from styrene doped with 2 wt% of 2,5-diphenylbenzoxazole and 0.03 wt% of 2-(4-styrylphenyl)benzoxazole, is determined to be as large as 60% $\\pm$ 2% of the anthracene light output. There is a potential to improve this value in the future by the optimization of the additives concentrations.

  3. 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSSIMIC) M07-4 Myocardial Blood Flow from Dynamic PET

    E-Print Network [OSTI]

    Duncan, James S.

    2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSSIMIC) M07 to CT or MR!. Independent Component Analysis (lCA) is an established technique in signal processing [1

  4. 48 51(2) avril/April 2005 Canadian Medical Physics Newsletter / Le bulletin canadien physique mdical 30 Years Ago: First PET Scanner in Canada

    E-Print Network [OSTI]

    Thompson, Chris

    CBF)in the exposed brain, both in animal experiments and during human surgery for arterial-venous malformations invasively. One of these techniques involved applying small silicon diode radiation detectors

  5. Lu.sub.1-xI.sub.3:Ce.sub.x--a scintillator for gamma ray spectroscopy and time-of-flight PET

    DOE Patents [OSTI]

    Shah, Kanai S.

    2007-02-06

    The present invention concerns very fast scintillator materials comprising lutetium iodide doped with Cerium (Lu.sub.1-xI.sub.3:Ce.sub.x; LuI.sub.3:Ce). The LuI.sub.3 scintillator material has surprisingly good characteristics including high light output, high gamma ray stopping efficiency, fast response, low cost, good proportionality, and minimal afterglow that the material is useful for gamma ray spectroscopy, medical imaging, nuclear and high energy physics research, diffraction, non-destructive testing, nuclear treaty verification and safeguards, and geological exploration. The timing resolution of the scintillators of the present invention provide compositions capable of resolving the position of an annihilation event within a portion of a human body cross-section.

  6. The Effects of PET-Lined and Epoxy-Coated Lead and Copper Service Lines on Metals Leaching, Total Organic Carbon, and Chlorine Residual in Drinking Water

    E-Print Network [OSTI]

    Breault, Zachary Andrew

    2014-12-31

    in lead levels and continuing lead release. Application of a lining or coating may provide a more effective and less expensive alternative than partial LSL replacement, both for reducing corrosion and for increasing homeowner participation. However...

  7. Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and SPECT and PET imaging

    DOE Patents [OSTI]

    Mease, R.C.; Mausner, L.F.; Srivastava, S.C.

    1994-03-08

    Cyclo agents are described which are useful in forming antibody-metal conjugates which are used for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2diamino cyclohexane-N,N,N',N'-tetra acetic acid. No Drawings

  8. Halide, Chromate, and Phosphate Impacts on LAW Glass for Dynamic Flowsheet 24590-WTP-MCR-PET-09-0037, Rev. 1

    SciTech Connect (OSTI)

    Gimpel, Rodney F.; Kruger, Albert A.

    2013-12-16

    Revision 1 of this Model Change Request changed Equation 6 in Attachment Al only. Melter studies have shown that halide, chromium, and phosphates can cause precipitation of solids that can interfer the melting process. Pilot melter data now shows what concentrations LAW glass can tolerate. These limits shall be incorporated into the existing LAW glass algorithm per Attachment Al.

  9. Lu.sub.1-xI.sub.3:Ce.sub.x-a scintillator for gamma-ray spectroscopy and time-of-flight pet

    DOE Patents [OSTI]

    Shah, Kanai S. (Newton, MA)

    2008-02-12

    The present invention includes very fast scintillator materials including lutetium iodide doped with Cerium (Lu.sub.1-xI.sub.3:Ce.sub.x; LuI.sub.3:Ce). The LuI.sub.3 scintillator material has surprisingly good characteristics including high light output, high gamma-ray stopping efficiency, fast response, low cost, good proportionality, and minimal afterglow that the material is useful for gamma-ray spectroscopy, medical imaging, nuclear and high energy physics research, diffraction, non-destructive testing, nuclear treaty verification and safeguards, and geological exploration.

  10. Detailed ads & listings Apartment locator map

    E-Print Network [OSTI]

    Tullos, Desiree

    -- 12-month Deposits: $300 refundable deposit Utilities Included: Water, sewer, garbage Restrictions Deposits: $300 refundable deposit Utilities Included: Water, sewer, garbage Restrictions: No pets Security Deposit after you move in.) Utilities Included: Water, sewer and garbage. Restrictions: No pets

  11. Waste product profile: Polyethylene terephthalate

    SciTech Connect (OSTI)

    Miller, C. [Environmental Industry Associations, Washington, DC (United States)

    1996-02-01

    Polyethylene terephthalate (PET) is a plastic resin used primarily to make bottles. Soft drinks are the primary product packaged in PET. Salad dressing, peanut butter, and other household and consumer products also use PET bottles. PET is also used for film, sheeting for cups and food trays, ovenable trays, and other uses. PET is a relatively new packaging resin, first commercialized in the early `70s. Because it is an ``engineered`` resin, it is more expensive than commodity resins such as high-density polyethylene (HDPE). The primary market for recycled PET is the fiber industry, which uses PET for carpet fiber, sweaters and other clothing, and for other uses. Recycled PET can also be used for food and beverage containers. Export markets, particularly Asian countries, are becoming increasingly important.

  12. FOREST SERVICE -U. S. DEPARTMENT OF AGRICULTURE Pacific Southwest

    E-Print Network [OSTI]

    -2- #12;Table 1.--Number of cuttings with roots, callus, or neither, by species, rooting medium Callused : Neither : Rooted : Callused: Neither No. Pet. No. No. No. Pet. No. No. SPONGE ROK 1 month

  13. How Do Investors Respond to Green Company Awards in China?1

    E-Print Network [OSTI]

    Lyon, Thomas P.

    milk and pet food, toxic toys, suicides among mistreated workers, and an unsafe high-speed rail system

  14. Phytologia (April 1, 2014) 96(2)110 Geographic variation in the volatile leaf oils J. phoenicea var. phoenicea from throughout its range

    E-Print Network [OSTI]

    Adams, Robert P.

    ) analyzed nrDNA and petN sequences for J. phoenicea L. (sensu stricto) from throughout the Mediterranean

  15. Phytologia (December 2011) 93(3) 293 TAXONOMY OF JUNIPERUS DELTOIDES

    E-Print Network [OSTI]

    Adams, Robert P.

    : LEAF TERPENOIDS AND SNPS FROM nrDNA AND petN Robert P. Adams Baylor University, Biology Department, One

  16. Asymmetrical Gene Flow in a Hybrid Zone of Hawaiian Schiedea (Caryophyllaceae) Species with Contrasting Mating Systems

    E-Print Network [OSTI]

    2011-01-01

    at four of the loci (rpS16, petN-psbM, psbE-petL, trnLpetL-psbE, ndhJ-trnF, petN-psbM, psbM-trnD), and the intronpetL-psbE, ndhJ-trnF [78], petN-psbM and psbM-trnD [79] and

  17. Medical Imaging Computed Tomography (CT)

    E-Print Network [OSTI]

    Massey, Thomas N.

    #12;LSO-APD Array Schematic #12;Time-of-Flight PET #12;Energy Spectrum with lutetium oxyorthosilicate

  18. Opinions from the Front Lines of Cat Colony Management Conflict

    E-Print Network [OSTI]

    Langerhans, Brian

    of free-roaming (outdoor pets and feral) domestic cats (Felis catus L.) is a long-standing international

  19. Complete plastome sequences of Equisetum arvense and Isoetes flaccida: implications for phylogeny and plastid genome evolution of early land plant lineages

    E-Print Network [OSTI]

    2010-01-01

    psbF psbK psbT b petB* b, e petN b atpB atpI b atpE atpF*UUG, and translocation of petN from the LSC to the SSC [35].

  20. Are You Polluting Our Lakes and Streams and the Chesapeake Bay?

    E-Print Network [OSTI]

    Hill, Wendell T.

    1 Are You Polluting Our Lakes and Streams and the Chesapeake Bay? Pet waste left to decay, and rivers. They include the following: · Pesticides · Household chemicals · Fertilizers · Oil and antifreeze · Pet waste When pet waste is washed into lakes or streams, the waste decays, using up oxygen

  1. 02-25225952 Ka.chiu@elsevier.com

    E-Print Network [OSTI]

    Wu, Yih-Min

    . Author name Editor #12; Analyze results "Journal of Nuclear Medicine" 1. "Journal of Nuclear Medicine""PET " "Journal of Nuclear Medicine""PET " 2009 #12; 2. Journal Homepage "Radiology"" PET""Journal of Nuclear Medicine" "Radiology" #12; - SJR 3. Compare journals in Journal AnalyzerJournal Analyzer SJR SJR

  2. Tracking Progress Last updated 6/2/2014 Current and Expected Energy From Coal for California 1

    E-Print Network [OSTI]

    2007 to 2012, energy from in-state coal and petroleum (pet) coke plants declined by 62 percent. These trends are shown in Figure 1. Eight in-state coal and pet coke plants retired or stopped operating in 2011 and 2012. Of the 16 in-state coal and pet coke plants that once operated in California, only two

  3. Sharing scientific data containing complex information requires new concepts and

    E-Print Network [OSTI]

    Lindeberg, Tony

    that generates new databases. The scientists submit raw PET and fMRI data to NEUROGENERATOR, which then processes and Karl Zilles TRENDS in Neurosciences Submission interface Raw data Processing chains PET fMRI Cyto Database products Plug-ins Raw Standard Statistical Databases Processing chain modules PET fMRI (a) (b) (c

  4. COMPUTATIONAL ANALYSIS AND MODELING OF GENOME-SCALE AVIDITY DISTRIBUTION OF TRANSCRIPTION FACTOR

    E-Print Network [OSTI]

    Wong, Limsoon

    in high-throughput technologies, such as ChIP-chip and ChIP-PET (Chromatin Immuno- Precipitation Paired,9,11]. The software suite for comprehensive processing and managing of raw Paired-End diTag (PET) sequence data were BINDING SITES IN CHIP-PET EXPERIMENTS VLADIMIR A. KUZNETSOV* 1 YURIY L. ORLOV 1 kuznetsov

  5. Profiles in garbage: Polyethylene terephthalate

    SciTech Connect (OSTI)

    Miller, C. [Environmental Industry Associations, Washington, DC (United States)

    1997-11-01

    Polyethylene terephthalate (PET) is a plastic resin used primarily to make bottles. Soft drinks -- along with salad dressing, fruit juices, peanut butter, and other household and consumer products -- use PET bottles. PET also is used for film, sheeting for cups and food trays, oven-safe trays, and other uses. PET is a relatively new packaging resin, first commercialized in the early 1970s. Because it is an ``engineered`` resin, PET is more expensive than commodity resins such as high-density polyethylene (HDPE) and, for the same reason, it is usually the highest valued plastic recyclable.

  6. Impact of {sup 18}F-Fluorodeoxyglucose Positron Emission Tomography Before and After Definitive Radiation Therapy in Patients With Apparently Solitary Plasmacytoma

    SciTech Connect (OSTI)

    Kim, Paul J.; Hicks, Rodney J.; Wirth, Andrew; Ryan, Gail; Seymour, John F.; Prince, H. Miles

    2009-07-01

    Purpose: To evaluate the impact of {sup 18}F-fluorodeoxyglucose positron emission tomography (FDG-PET) on management of patients with apparently isolated plasmacytoma. Methods and Materials: Twenty-one patients with apparently solitary plasmacytoma who underwent FDG-PET for staging or restaging were identified from a central PET database. They were either candidates for or had received definitive radiation therapy (RT). Results: Seventeen patients had initial staging scans for bone (n = 11) or soft tissue (n = 6) plasmacytomas, and 11 had PET scans after RT. Only 1 of 14 known untreated sites of plasmacytoma was not identified on staging PET (lesion sensitivity = 93%). Three plasmacytomas were excised before PET. Staging PET influenced management in 6 of 17 patients (35%) by showing multiple myeloma (n = 1), discouraging RT after complete resection (n = 1), excluding plasmacytoma at a second site (n = 1), by increasing RT fields (n = 2), or by suggesting sarcoidosis (n = 1). Fifteen of 17 patients with initial staging PET scans received definitive RT. Restaging PET scans after RT showed complete metabolic response in 8 of 11 cases and progressive disease in 2. Two patients with either no response or partial metabolic response had late responses. Staging sestamibi and PET scans were concordant in five of six occasions (one sestamibi scan was false negative). Conclusions: FDG-PET has value for staging and RT planning in plasmacytoma and potentially could have a role in response-assessment after RT. Slow resolution of FDG uptake posttreatment does not necessarily imply an adverse prognosis.

  7. Protonation Studies of a Tungsten Dinitrogen Complex Supported by a Diphosphine Ligand Containing a Pendant Amine

    SciTech Connect (OSTI)

    Weiss, Charles J.; Egbert, Jonathan D.; Chen, Shentan; Helm, Monte L.; Bullock, R. Morris; Mock, Michael T.

    2014-05-12

    Treatment of trans-[W(N2)2(dppe)(PEtNMePEt)] (dppe = Ph2PCH2CH2PPh2; PEtNMePEt = Et2PCH2N(Me)CH2PEt2) with three equivalents of tetrafluoroboric acid (HBF4?Et2O) at -78 °C generated the seven-coordinate tungsten hydride trans-[W(N2)2(H)(dppe)(PEtNMePEt)][BF4]. Depending on the temperature of the reaction, protonation of a pendant amine is also observed, affording trans-[W(N2)2(H)(dppe)(PEtNMe(H)PEt)][BF4]2, with formation of the hydrazido complex, [W(NNH2)(dppe)(PEtNMe(H)PEt)][BF4]2, as a minor product. Similar product mixtures were obtained using triflic acid (HOTf). Upon acid addition to the carbonyl analogue, cis-[W(CO)2(dppe)(PEtNMePEt)], the seven-coordinate carbonyl-hydride complex, trans-[W(CO)2(H)(dppe)(PEtN(H)MePEt)][OTf]2 was generated. The mixed diphosphine complex without the pendant amine in the ligand backbone, trans-[W(N2)2(dppe)(depp)] (depp = Et2P(CH2)3PEt2), was synthesized and treated with HBF4?Et2O, selectively generating a hydrazido complex, [W(NNH2)(F)(dppe)(depp)][BF4]. Computational analysis was used to probe proton affinity of three sites of protonation, the metal, pendant amine, and N2 ligand in these complexes. Room temperature reactions with 100 equivalents of HOTf produced NH4+ from reduction of the N2 ligand (electrons come from W). The addition of 100 equivalents HOTf to trans-[W(N2)2(dppe)(PEtNMePEt)] afforded 0.88 ± 0.02 equivalents NH4+, while 0.36 ± 0.02 equivalents of NH4+was formed upon treatment of trans-[W(N2)2(dppe)(depp)], the complex without the pendant amine. This work was supported as part of the Center for Molecular Electrocatalysis, an Energy Frontier Research Center funded by the U.S. Department of Energy Office of Science, Office of Basic Energy Sciences. Computational resources were provided by the National Energy Research Scientific Computing Center (NERSC) at Lawrence Berkeley National Laboratory. Pacific Northwest National Laboratory is operated by Battelle for DOE.

  8. Synthesis and characterization of phosphine adducts of thorium borohydride, Crystal structures of Th(BH4)4(PEt3)2 and Th(BH4)4(Me2PCH2CH2PMe2)2

    E-Print Network [OSTI]

    Girolami, Gregory S.

    Synthesis and characterization of phosphine adducts of thorium borohydride, Th(BH4)4 Crystal: Thorium Phosphine Trialkylphosphine Borohydride Tetrahydroborate Crystal structures a b s t r a c NMR spectroscopy. The results show that thorium complexes of unidentate phosphines can be made

  9. PET 424304 2015 Exercises 3+4 of 4 10 Feb + 13 Feb 2015 1. ideal gas: s = s2-s1 = cpln(T2/T1) -R ln(p2/p1) (T << Tcrit; p << pcrit)

    E-Print Network [OSTI]

    Zevenhoven, Ron

    /mol = 31,25 mol/s s = - R· ln(1/20) = 24,9 J/(molK) x = ·T°· s = 31,25·293·24,9 = 228,1 kW 2. 1 kg Al 2015 Exercises 3+4 of 4 10 Feb + 13 Feb 2015 3. Per kg steel: nFe = 17,55 mol, b°Fe = 374,3 kJ/mol nC = 0,50 mol, b°C = 410,3 kJ/mol nMn = 0,13 mol, b°Mn = 487,7 kJ/mol nS = 0,09 mol, b°S = 609,6 kJ/mol n

  10. Comparative chloroplast genomics: Analyses including new sequences from the angiosperms Nuphar advena and Ranunculus macranthus

    E-Print Network [OSTI]

    2007-01-01

    but differ in including petN, psbM, and rpl23 among the 10chlL matK ndhB ndhD ndhF ndhG petN psaJ psbC psbL rpl2 rpl36psbM:trnD clpP-5’ trnC:petN rps16:trnQ trnK:rps16 trnP:psaJ

  11. The Development of an Optimized Generator Production Method for the Routine Production of Zinc-62/Copper-62 Generator Systems 

    E-Print Network [OSTI]

    Cantrell, Tyler Lee

    2015-05-06

    of common positron emitters used for PET imaging ……….. 4 Table 2 List of positron labelled radiopharmaceuticals for PET……………….. 5 Table 3 The radioactive decay data for 62Zn represented by the energy, intensity, and decay …………………………………………………… 12... with focuses in cancer diagnosis/management, cardiac surgery, and neurology/psychiatry, respectively (Bailey et al., 2005). PET imaging is currently very powerful with the use of FDG, an effective and powerful radiopharmaceutical, but it also currently...

  12. Flea Control 

    E-Print Network [OSTI]

    Merchant, Michael E.

    2002-08-23

    This publication will help you identify fleas and learn their behaviors and potential dangers to pets and humans. Included are methods for controlling fleas indoors and out....

  13. Phytologia (December 2009) 91(3) 571 VARIATION AMONG THE SMOOTH-LEAF MARGINED

    E-Print Network [OSTI]

    Adams, Robert P.

    -coumarate: CoA Ligase, Abscisic acid-insensitive 3, petN, psbM, SNPs, taxonomy. The smooth-leaf margined

  14. Phytologia (August 2012) 94(2) 159 TAXODIUM (CUPRESSACEAE): ONE, TWO OR THREE

    E-Print Network [OSTI]

    Adams, Robert P.

    regions (petN- psbM, trnS-trnG, ycf-psbA) were utilized to examine variation in Taxodium distichum, T. d

  15. Constructive hierarchy through entitlement: inequality in lithic resource access among the ancient Maya of Blue Creek, Belize 

    E-Print Network [OSTI]

    Barrett, Jason Wallace

    2005-02-17

    ...............................................................................75 Karst Landscape of the Yucatan Platform and Pet?n Plateau .75 Chert and Chalcedony Formation............................................76 Soils.........................................................................................79 Climate...

  16. Phytologia (April 2009) 91(1)160 A NEW GENUS, HESPEROCYPARIS, FOR THE CYPRESSES

    E-Print Network [OSTI]

    Adams, Robert P.

    , Xanthocyparis, Juniperus, nrDNA(ITS), 4-coumarate: CoA Ligase, Abscisic acid-insensitive 3, petN, psb

  17. Phytologia (August 2010) 92(2)156 TAXONOMY OF JUNIPERUS OXYCEDRUS

    E-Print Network [OSTI]

    Adams, Robert P.

    TERPENOIDS AND SNPS FROM nrDNA AND petN Robert P. Adams Biology Department, Baylor University, Box 727 Gruver

  18. 185Phytologia (August 2011) 93(2) TAXONOMY AND EVOLUTION OF JUNIPERUS COMMUNIS

    E-Print Network [OSTI]

    Adams, Robert P.

    , geographic variation, nrDNA, petN, trnDT, trnSG, SNPs, Pleistocene migrations. #12;Phytologia (August 2011

  19. Phytologia (August 2009) 91(2) 353 VARIATION IN JUNIPERUS DURANGENSIS AND RELATED

    E-Print Network [OSTI]

    Adams, Robert P.

    (CUPRESSACEAE): ANALYSIS OF nrDNA AND petN SNPs Robert P. Adams Biology Department, Baylor University, Waco, TXITS ITS-42F/ ITSB+57R K 50ºC (94-50x30) 1270-1272 petN petN5F/psbM111R E 50ºC (94-50x30) 839-845 Primers on Juniperus sequences): ITSA-42F = GAT TGA ATG ATC CGG TGA AGT ITSB+57R = ATT TTC ATG CTG GGC TCT petN - psb

  20. Performance Assessment for Transuranic Waste

    National Nuclear Security Administration (NNSA)

    by high PET and low precipitation. * The alkaline soil conditions which retard the migration and reduce the solubility of most cationic metals. * The adaptations of native...

  1. Production of Polyethylene Terephthalate using a Nonmetallic Catalyst Dr. Marsha Winston1, Jared Langson2, Angus Ferguson2, Dr. Robert Posey2

    E-Print Network [OSTI]

    Production of Polyethylene Terephthalate using a Nonmetallic Catalyst Dr. Marsha Winston1, Jared Department of Chemistry Polyethylene terephthalate (PET) is a condensation polymer of terephthalic acid (HOOC

  2. Jefferson Lab Human Resources

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    pets to political issues, ethnic groups to sports teams, and entertainers to styles of music. At the same time, you will be assisting psychological research on thoughts and...

  3. Positron emission tomography probes for imaging immune activation and selected cancers

    DOE Patents [OSTI]

    Radu, Caius G. (Los Angeles, CA); Witte, Owen N. (Los Angeles, CA); Nair-Gill, Evan David (Los Angeles, CA); Satyamurthy, Nagichettiar (Los Angeles, CA); Shu, Chengyi J. (Los Angeles, CA); Czernin, Johannes (Los Angeles, CA)

    2012-01-24

    Compounds for use as PET probes and methods for synthesizing and using these, comprising [.sup.18F]D-FAC and other cytosine and adenosine analogs.

  4. Biofuel alternatives to ethanol: pumping the microbial well

    E-Print Network [OSTI]

    Fortman, J. L.

    2010-01-01

    Y. (2007) Biodiesel from microalgae. Biotechnol. Adv. 25,fuel production using microalgae. J. Jpn. Pet. Inst. 48,Figure 1). Biodiesel from microalgae-derived lipids has been

  5. CLIC RF High Power Production Testing Program

    E-Print Network [OSTI]

    Syratchev, I; Tantawi, S

    2008-01-01

    The CLIC Power Extraction and Transfer Structure (PETS) is a passive microwave device in which bunches of the drive beam interact with the impedance of the periodically loaded waveguide and generate RF power for the main linac accelerating structure. The demands on the high power production (~ 150 MW) and the needs to transport the 100 A drive beam for about 1 km without losses, makes the PETS design rather unique and the operation very challenging. In the coming year, an intense PETS testing program will be implemented. The target is to demonstrate the full performance of the PETS operation. The testing program overview and test results available to date are presented.

  6. Sandia Energy - Offshore Wind RD&D: Large Offshore Rotor Development

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    utilized balsa in critical buckling areas (Trailing Edge Panel: Inboard) and PET foam in the non-critical buckling areas (Trailing Edge Panel: Outboard), as shown in the...

  7. Materials Today Communications 2 (2015) e33e37 Contents lists available at ScienceDirect

    E-Print Network [OSTI]

    Ritchie, Robert

    2015-01-01

    in stress- bearing applications such as bulletproof body armor, shielding for sports equipment, and fiber, dynamic mechan- ical analysis; PEB, poly(ethylene-butylene); PET, polyethylene terephthalate; PS

  8. Flea Control (Spanish) 

    E-Print Network [OSTI]

    Merchant, Michael E.

    2002-08-23

    This publication will help you identify fleas and learn their behaviors and potential dangers to pets and humans. Included are methods for controlling fleas indoors and out.

  9. Electronics Come of Age: A Taxonomy for Miscellaneous and Low Power Products

    E-Print Network [OSTI]

    Nordman, Bruce; Sanchez, Marla C.

    2006-01-01

    Heating, boiler Heating, furnace baseboard, floor or wallFloor polisher Pet fence Power tool Power tool, cordless Pump, sump Pump, well Water heating

  10. Integrated X-Ray Reflectivity Measurements for Elliptically Curved...

    Office of Scientific and Technical Information (OSTI)

    provides valuable information about the temperature and density of a compressed pellet in a plasma. Elliptically curved pentaerythritol (PET) crystals are used as components...

  11. Precise Measurement of Strontium-82 Radioactivity in the Sr-Rb...

    Office of Science (SC) Website

    Precise Measurement of Strontium-82 Radioactivity in the Sr-Rb PET Generator Nuclear Physics (NP) NP Home About Research Facilities Science Highlights Benefits of NP Applications...

  12. September 2015 Most Viewed Documents for Biology And Medicine...

    Office of Scientific and Technical Information (OSTI)

    September 2015 Most Viewed Documents for Biology And Medicine Measuring dopamine release in the human brain with PET Volkow, N.D. Brookhaven National Lab., Upton, NY (United...

  13. June 2015 Most Viewed Documents for Biology And Medicine | OSTI...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    June 2015 Most Viewed Documents for Biology And Medicine Measuring dopamine release in the human brain with PET Volkow, N.D. Brookhaven National Lab., Upton, NY (United...

  14. Growing the Tool Box for Medical Imaging: The Selenium-72/Arsenic...

    Office of Science (SC) Website

    methodologies of making self-contained delivery systems for the radioisotope 72As for future clinical applications. The Impact Positron emission tomography (PET) is a powerful...

  15. BNL-52351-2003 Brookhaven National Laboratory's

    E-Print Network [OSTI]

    Ohta, Shigemi

    ..................................................................................................................................... 1 Management Process-Enhancementof Brain Patterns in PET Images .................................................................................................... 21 Development of CZT Array Detector Technology for Synchrotron Radiation Applications.......25 New

  16. ClearPEM clarifies breast cancer diagnosis

    E-Print Network [OSTI]

    Frisch, Benjamin

    2013-01-01

    Knowledge gained in developing particle detectors for the LHC has been used to create a dedicated PET device for breast scans.

  17. A Comparison of the First Two Sequenced Chloroplast Genomes in Asteraceae: Lettuce and Sunflower

    E-Print Network [OSTI]

    Timme, Ruth E.

    2009-01-01

    trnR-trnG trnD-trnY trnC-petN trnT-trnL ycf1-rps15 ndhD-ccsA2003 Panero and trnG-trnT petN-psbM rps16-trnQ trnG-trnfM

  18. Phytologia (April 2011) 93(1)146 DNA BARCODING A JUNIPER: THE CASE OF THE SOUTH

    E-Print Network [OSTI]

    Adams, Robert P.

    bp from five gene regions (nrDNA, petN- psbM, trnD-trnT, trnL-trnF, trnS-trnG) was sufficient.5 units Epi-Centre Fail-Safe Taq #12;Phytologia (April 2011) 93(1)148 polymerase, 15 µl 2x buffer E (petN

  19. RESUME February 2013 WILLIAM DAVID CONSTANT

    E-Print Network [OSTI]

    Cai, Steve C. S.

    Technician, United States Forest 1974 May-August - Service, Pineville, Louisiana Industry: 1977 - 1978 Processing Lab & Institute for Recyclable Materials. 1991 - 2003 - Assistant Director, US EPA Hazardous of Petroleum Fluids PetE 7232 Thermal Methods of Enhanced Oil Recovery PetE 4057 Undergraduate Production Lab

  20. Molecular Orientation and Relaxation of Poly(ethylene terephthalate) by Polarization Modulation Infrared Spectroscopy

    E-Print Network [OSTI]

    Pezolet, Michel

    (ethylene terephthalate) (PET) is induced during its processing via fiber spinning or blow molding. This polymer can crystals. Finally, shrinkage experiments on oriented PET have demonstrated that, beyond a certain degree of orientation, shrinkage is hindered due to the development of crystallinity.8,9 To investigate the orientation

  1. POSITION DESCRIPTION A. IDENTIFICATION

    E-Print Network [OSTI]

    Farrell, Anthony P.

    circumstances. The student will assist Manager - Animal Welfare at the Charlie's Pet Food Bank (CFB) held weekly at Mission Possible 543 Powell Street, Vancouver. CFB is a BCSPCA Program where pet food, accessories to improve individual welfare for clients accessing CFB, and provide training and outreach by visiting

  2. A passion for the world The graying of rural medicine

    E-Print Network [OSTI]

    Gopalakrishnan, K.

    - grader at Riverside Middle School in Williamston, is participating in an after-school, STEM-based program The inaugural School of Dental Medicine graduating class #12;B R E T R I E V E R R E L A X A T I O N Scout. The library teamed with Pet Partners to present three pet therapy sessions, which brought animals

  3. P-7 / D. R. Cairns P-7: Wear Resistance of Indium Tin Oxide Coatings on Polyethylene

    E-Print Network [OSTI]

    Cairns, Darran

    P-7 / D. R. Cairns P-7: Wear Resistance of Indium Tin Oxide Coatings on Polyethylene Terephthalate The wear mechanisms of the Indium Tin Oxide (ITO) coated Polyethylene Terephthalate (PET) topsheet). The bottom substrate is typically glass and the top sheet a polyester such as Polyethylene Terephthalate (PET

  4. Reinforcement Learning for a Vision Based Mobile Robot Chris Gaskett, Luke Fletcher and Alexander Zelinsky

    E-Print Network [OSTI]

    obstacles. 2 Robot System Architecture Our platform for research is a Nomad 200 with a Sony EVI-D30 colour is detected by looking for car- pet. A grid of 5×7 correlations are performed across the image space against a pre-loaded image of the car- pet. The result is a matrix indicating the likelihood that regions ahead

  5. Surface Modification by Atmospheric Pressure Plasma for Improved Bonding

    E-Print Network [OSTI]

    Williams, Thomas Scott

    2013-01-01

    PE), polystyrene (PTFE), (PS), polyamide-6 poly(methyl (PA-PE, PA-6, polyimide (PI), and PTFE. Noeske et al. [46] haveHe/O 2 Kapton DBD He/O 2 PTFE PET PET PU PP PP DBD DBD DBD

  6. REQUEST FOR RADIATION DOSIMETRY (RSO Form 7) 4.14 EH&S OFFICE USE

    E-Print Network [OSTI]

    Sniadecki, Nathan J.

    is needed: Dominant Hand Right Left AND Size Sm Med Lg XL Size 5-6 Size 7-8 Size 10-11 Size 13: Working directly with radiopharmaceuticals (except PET) [P and Ring] Working directly with PET Medical Care Care for patients receiving 20 mCi of radiopharmaceuticals or brachytherapy [P] Not Listed

  7. U.S. Life Cycle Inventory Database Dataset Additions -Type / Category Dataset Name

    E-Print Network [OSTI]

    Manufacturing Polylactide Biopolymer Resin, at plant Chemical Manufacturing Recycled Postconsumer HDPE Pellet Recycled Postconsumer PET Flake Recycled Postconsumer PET Pellet Waste Management and Remediation Service Bole Only slash in the Woods, INW Delimbing, slide boom delimber Felling, feller buncher, > 200 HP, INW

  8. Phytologia (April 2010) 92(1)44 SPECIATION OF JUNIPERUS CEDRUS AND J. MADERENSIS

    E-Print Network [OSTI]

    Adams, Robert P.

    Laguna, Tenerife, Canary Islands, Spain ABSTRACT Analyses of nrDNA and petN-PsbM sequence data, combined of the Canary Islands as it is from J. oxycedrus. These data support the recognition of the Madeira juniper, Cupressaceae, Madeira Island, Canary Islands, nrDNA, cp petN-psbM, taxonomy. In a previous paper of this issue

  9. Classification in combined phrases: noun-noun conjunctions and intersective, subsective and privative adjective-noun combinations.

    E-Print Network [OSTI]

    Costello, Fintan

    is a defining feature of language. But how are the meanings of multiword phrases such as "pet fish", "skilful? Meaning depends on categorisation: to understand a single word such as "fish" is to be able to correctly classify items in the single category fish; to understand a phrase such as "pet fish" is to be able

  10. CATS AT AUB Cats are a familiar and tolerated presence on the AUB campus. Nonetheless, these cats are

    E-Print Network [OSTI]

    create unhygienic conditions and unpleasant odors in buildings intended for teaching and research. Policy immediately be removed to the main campus area. 3. In collaboration with the AUB Animal Welfare Club be relocated from AUBMC's premises or as family pets. Cats kept as family pets should be provided with a collar

  11. Dynamic Response Characteristics of a Novel Electrolyte Michael C. Hollenbeck1,2

    E-Print Network [OSTI]

    Stevens, Ken

    a multiphysics model for a polymer- electrolyte transistor (PET) simulated in COMSOL Multiphysics. Dynamic the dynamic response of the LSL polymer-electrolyte transistor (PET), utilizing the finite element solverDynamic Response Characteristics of a Novel Electrolyte Transistor Michael C. Hollenbeck1,2 , Hoda

  12. STATE RESTORATION IN DISTRIBUTED SYSTEMS Philip M. MERLIN

    E-Print Network [OSTI]

    Newcastle upon Tyne, University of

    Technion - Israel institute of Technology Haifa, Israel Brian RANDELL Computing Laboratory The University to continue normal processing,, Such backward error recovery © 1978 IEEE. Personal use of this material;2 graphs are similar to the Occurrence Nets (also called Causal Nets) described in [HOL68, PET76, PET77

  13. Nanocrystalline Silicon Thin Film Transistors on Optically Clear Polymer Foil Substrates Alex Kattamis, I-Chun Cheng, Ke Long, James C. Sturm, Sigurd Wagner

    E-Print Network [OSTI]

    -ethylene terephthalate (PET) [5] . However since PET has a glass transition temperature (Tg) process areas, compared to TFTs of amorphous silicon. Introduction Flexible displays are the next technology using fabrication processes that already have been developed for glass with only minor changes

  14. FPGA-Based Front-End Electronics for Positron Emission Tomography

    E-Print Network [OSTI]

    Hauck, Scott

    technology for a data acquisition system for positron emission tomography (PET) scanners. Our laboratory, Design, Verification Keywords PET, FPGA, Digital Signal Processing, Pulse Timing, Event Localization 1 to process the incoming data without the complexity of an application-specific circuit. Technology advances

  15. Use of Physical Models to Facilitate Transfer of Physics Learning to Understand Positron Emission Tomography*

    E-Print Network [OSTI]

    Zollman, Dean

    in order to understand the image construction process in PET. For this purpose we conduct teaching of learning from the models of the activities to the PET image construction process. #12;METHODOLOGY Sixteen of the physical models in transferring physics ideas to understanding positron emission tomography technology

  16. Heat and Metal Transfer in Gas Metal Arc Welding Using Argon and Helium

    E-Print Network [OSTI]

    Eagar, Thomas W.

    condensation on the side of the electrode. I. INTRODUCTION THE shielding gas composition is a critical process. Massachusens Institute of Technology. Cambridge, MA 02 {39. Manuscript submitted August II. 1993- stead, a 90 pet helium-10 pet iron vapor gas mixture was used in the calculations. A more in

  17. JOURNAL DE PHYSIQUE Colloque C8, suppl6ment au n012, Tome 48, decembre 1987

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    - .The predominant end groups are -CH -CH2-OH and 2- 2- 2 -COOH. $uring processing PET can be stretched ON THE MECHANICAL PROPERTIES OF CRYSTALLINE PET S. EL-SAYED" and R. DE BATIST*" Physics Department, SCK/CEN, B-2400 Mol, Belgium "~ationalCentre for Radiation Research and Technology, Atomic Energy Authority, Cairo

  18. 342 Int. J. Data Mining and Bioinformatics, Vol. Cocluster analysis of thalamo-cortical fibre tracts

    E-Print Network [OSTI]

    Lu, Shiyong

    's Hospital of Michigan PET Center, 3901 Beaubien Blvd Detroit, MI, 48201, USA E-mail: otto@pet brain processes. In this paper · We propose a new partitioning paradigm, called coclustering, in order BE from Beijing Information Technology Institute, after which, she spent a few years working for IBM

  19. Measurement of Cerebral Glucose Metabolic Rates in the Anesthetized Rat by Dynamic

    E-Print Network [OSTI]

    Smith, Carolyn Beebe

    - thetized rats with the ATLAS (Advanced Technology Laboratory Animal Scanner) small animal PET scanner and biochemical processes, and it does so with minimal invasiveness. The spatial resolution of typical PETF-FDG, the ATLAS Small Animal PET Scanner, and Arterial Blood Sampling Kazuaki Shimoji, MD1; Laura

  20. DOI: 10.1002/chem.201000607 Conformational Structure and Energetics of 2-Methylphenyl(2'-

    E-Print Network [OSTI]

    Shen, Jun

    potential radiotracers for molecular imaging in vivo with posi- tron emission tomography (PET). This process imaging with positron emission to- mography (PET).[2] In view of these increasing synthetic ap- plications for Information Technology, National Institutes of Health Department of Health and Human Services, Building 12A

  1. Volume 9 No.4 -Spring2012 SCIENCEWISESpring 2012

    E-Print Network [OSTI]

    Chen, Ying

    of the physics of antimatter to better understand the underlying process of PET scans - ultimately working GRACE Australian space technology to monitor groundwater I thought I'd use the editorial in this edition towards better PET scanners than we have today." The scientists are hoping that eventually this work

  2. Nanopatterning Fabrication of a 60-nm-Diameter Perfectly Round

    E-Print Network [OSTI]

    660%. This new technology can be scaled to much larger areas (including roll-to-roll web processing-diameter, perfectly round metal dots over a large area on a polyethylene terephthalate (PET) substrate with high (HSQ) layer on top of PET, nanoimprint litho- graphy, and self-perfection by liquefaction (SPEL

  3. Localization of Fiducial Skin Markers in MR Images using Correlation Pattern

    E-Print Network [OSTI]

    , as is the case with MRI and PET imagery. The process of automating the detection of these markers needs moreLocalization of Fiducial Skin Markers in MR Images using Correlation Pattern Recognition for PET , Roger Easton1 1 Chester F. Carlson Center for Imaging Science at the Rochester Institute of Technology

  4. A Locus in Human Extrastriate Cortex for Visual Shape Analysis

    E-Print Network [OSTI]

    Kanwisher, Nancy

    Positron emission tomography (PET)was used to locate an area in human extrastriate cortex that subserves a specific component process of visual object recognition. Regional blood flow increased in a bilateral- tional brain imaging studies using PET and fMRI have discovered areas in human visual cortex that contain

  5. Research Assistant Tracking Code

    E-Print Network [OSTI]

    Simmons, Craig A.

    with neuroimaging technologies (MRI, EEG, MEG, PET, etc.). Working with technicians and scientists in collaborating & image processing, #12;statistics/data analysis, MRI and/or PET data acquisition Shell scripting in Unix control and processing, software development and data visualization. Assisting in maintaining

  6. The 8 bits 100 MS/s Pipeline ADC for the INNOTEP Project TWEPP-09 S. Crampon a,c

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    with a 0,35µm SiGe technology. I. INTRODUCTION Positron Emission Tomography (PET) scanners have been of coincidence (line of response, or LOR). PET scanners should make use of low-noise and rapid electronics, analog filtering, A- to-D conversion and digital signal processing, as shown in Fig 1. We present

  7. Obligations with deadlines and maintained interdictions in privacy regulation frameworks

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    , research has first fo- cused on the so-called Privacy-Enhancing Technologies (PETs), the technical means existing Internet-oriented PETs with respect to their aims (identity management, IP anonymization...) [6 (user information, user consent, data update and retractation, process justification, data retention

  8. Doctoral Candidates/ PhD (as structured or as supervised doctoral project)

    E-Print Network [OSTI]

    Schüler, Axel

    process. The surface of PET materials can be modified by hydrolytic bacterial and fungal enzymes-hydrolyzing microbial enzymes, and their employment in a novel biocatalytic PET functionalization process. The project of Leipzig in Leipzig, Germany Institute for Biochemistry Chair for Microbiology and Bioprocess Technology

  9. DEFINING RADIOTHERAPY TARGET VOLUMES USING 18F-FLUORO-DEOXY-GLUCOSE POSITRON EMISSION TOMOGRAPHY /

    E-Print Network [OSTI]

    Brest, Université de

    further the process of making available new technology. We therefore suggest a more radical stance) investigated the use of fixed thresholds to define NSCLC tumors PET volumes exhibiting heterogeneous uptake. They found no correlation between the CT-based and the PET-based volumes, and associated the observed

  10. MILXView: A medical imaging, analysis and visualization platform.

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    . The aim of the Alzheimer's disease project is to develop algorithms and software to process MRI and PET in acquisition technology. However, image analysis and interpretation is still primarily performed manually with functional and molecular information from PET to allow early detection of changes related to disease

  11. ORNL 2011-G00250/tcc UT-B ID 200701918

    E-Print Network [OSTI]

    Pennycook, Steve

    -Corrected Tomographic Images Technology Summary High quality three-dimensional images from conventional MRI, CT, PET the neurological and physiological processes under analysis. This invention corrects for any motion during a scan systems to obtain high-resolution CT, PET, and SPECT images of unrestrained live subjects. Data from

  12. Professor David Wyper PhD Director: SINAPSE

    E-Print Network [OSTI]

    Greenaway, Alan

    in 1983 by Professor John Mallard at the University of Aberdeen and manufactured by M&D Technology Ltd #12 industrial partners 3. Underlying reasons for interest from academics 4. Obstacles ­ IP, processes, legal; PET tracer discovery and validation; PET in drug discovery. Support in the form of part funding for Ph

  13. Proceedings of the 27th Ris International Symposium on Materials Science

    E-Print Network [OSTI]

    (220 °C) processing PET. Tension-tension fatigue properties for the two materials are shown in Fig. 2 yarn is commingled in an air texturing process where glass fibres and L-PET fibres are blown into each Roskilde, Denmark ABSTRACT Technology and semi-raw materials for vacuum consolidation of thermoplastic

  14. 2012NatureAmerica,Inc.Allrightsreserved. nature biotechnology advance online publication

    E-Print Network [OSTI]

    Bhatia, Sangeeta

    to tailor agents to exploit host physiol- ogy or interface with disease-specific molecular processes filtration rates, fluorodeoxyglucose positron emis- sion tomography (PET) to unveil regions of increased, which require patients to be on site (e.g., PET and magnetic resonance imaging) and preclude remote data

  15. (Bandettini, Neuroimaging Methods) What's new in neuroimaging methods?

    E-Print Network [OSTI]

    Baker, Chris I.

    MRI interpretation, new functional MRI contrasts, MRI technology, MRI paradigms and processing Resting state fluctuations fMRI decoding multivariate analysis Positron emission tomography PET 2, and positron emission tomography (PET). More detail is included on fMRI, as subsections include: functional

  16. FPGA-Based Pulse Parameter Discovery for Positron Emission Tomography.

    E-Print Network [OSTI]

    Hauck, Scott

    technology for a data acquisition system for a positron emission tomography (PET) scanner. The University Programmable Gate Arrays (FPGAs) are capable of performing complex digital signal processing algorithms of Washington is producing a series of high-resolution, small-animal PET scanners that utilize FPGAs as the core

  17. Post-Doctorates Postdoctoral stay up to 12 months

    E-Print Network [OSTI]

    Schüler, Axel

    in a finishing process. The surface of PET materials can be modified by hydrolytic bacterial and fungal enzymes-hydrolyzing microbial enzymes, and their employment in a novel biocatalytic PET functionalization process. The project Technology Programme website http://www.biochemie.uni-leipzig.de/agz/ Research project description

  18. Aridity changes in the Tibetan Plateau in a warming climate

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Gao, Yanhong; Li, Xia; Leung, Lai-Yung R.; Chen, Deliang; Xu, Jianwei

    2015-03-10

    Desertification in the Tibetan Plateau (TP) has drawn increasing attention in the recent decades. It has been postulated as a consequence of climate aridity due to the observed warming. This study quantifies the aridity changes in the TP and attributes the changes to different climatic factors. Using the ratio of P/PET (precipitation to potential evapotranspiration) as an aridity index to indicate changes in dryness and wetness in a given area, P/PET was calculated using observed records at 83 stations in the TP, with PET calculated using the Penman–Monteith (PM) algorithm. Spatial and temporal changes of P/PET in 1979-2011 are analyzed.more »Results show that stations located in the arid and semi-arid northwestern TP are becoming significantly wetter and stations in the semi-humid southeastern TP are becoming drier, though not significantly, in the recent three decades. The aridity change patterns are significantly correlated with precipitation, sunshine duration and diurnal temperature range changes at confidence level of 99.9% from two-tail t-test. Temporal correlations also confirm the significant correlation between aridity changes with the three variables, with precipitation being the most dominant driver of P/PET changes at interannual time scale. PET changes are insignificant but negatively correlated with P/PET in the cold season. In the warm season, however, correlation between PET changes and P/PET changes are significant at confidence level of 99.9% when the cryosphere melts near the surface. Significant correlation between wind speed changes and aridity changes occurs in limited locations and months. Consistency in the climatology pattern and linear trends in surface air temperature and precipitation calculated using station data, gridded data, and nearest grid-to-stations for the TP average and across sub-basins indicate the robustness of the trends despite the large spatial heterogeneity in the TP that challenge climate monitoring.« less

  19. Prediction of Weld-Metal Composition During Flux-Shielded Welding

    E-Print Network [OSTI]

    Eagar, Thomas W.

    . ·due tn tire slrarr n·actian times and farge tlrcrma{ gra,fients inherent in the process. Nonetheless. In the .tint. a series (~r a1·cr one !rune/red H·dd.1. ll'itlr initialmwrgcrnt·sc l'(lrying from 0.01 pet to 3.1 pet. siliconmryi11g.from 0.002 rwt to3.2 pet. a11el lmsicin· index nrrrillg.fi·nm 0.2 to -1.0. 11·cre

  20. Atividade DE DE ExP Est proj mon ic ext PET eJr PartEvtapEvtorgEvtcurProfrepAcadofDidporgInstvoluntCultArt Cert Carga Mx. Validvel 60 30 60 60 60 60 60 60 60 60 30 10 12 60 10 12 12 12 12 60

    E-Print Network [OSTI]

    Paraná, Universidade Federal do

    Oliveira Costa 4 4 22 Artur Victor Marino 12 12 23 Barbara N Rodrigues 2 2 24 Bruna de Miranda da Silva 60 Isabelle Cavalcanti Baroni 60 2 24 86 136 Jeovane Honório Alves 60 60 30 4 12 6 12 184 137 Jéssika de Paulo Leduc Braciak 0 146 João Pedro Fabricio de Meira Albach 4 12 12 28 148 Jonasta S 0 149 Jose A F

  1. Women @ Energy: Joanna Fowler | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    is now the most widely used PET tracer for neuroscience and for diagnosis and managing cancer. In 2012 the NY chapter of the American Chemical Society designated the Chemistry...

  2. Native and exotic freshwater turtle and tortoise trade in Texas 

    E-Print Network [OSTI]

    Ceballos Fonseca, Claudia Patricia

    2001-01-01

    governmental organizations, the pet and meat industries, reptile expositions, zoos, aquariums, and Texas herpetological societies by mail, phone calls, or visits. In 1999, 4 turtle species accounted for 98% of collections from the wild. Between 1995 and 2000 a...

  3. Phytologia (August 2010) 92(2)266 VARIATION IN nrDNA AND cpDNA OF JUNIPERUS

    E-Print Network [OSTI]

    Adams, Robert P.

    . occidentalis, J. osteosperma, Cupressaceae, nrDNA, petN- psbM, trnD-trnT, trnL-trnF, trnS-trnG, SNPs

  4. Supporting Online Materials Interface Engineering by Piezoelectric Potential in ZnO-based

    E-Print Network [OSTI]

    Wang, Xudong

    ; ITO layer is 200 nm thick and PET is 75 µm thick) was cleaned by acetone, ethanol and DI water. A speed- controlled motor with wedged shaft drove the dynamic and static bending of the PMMA cantilever

  5. Nuclear Instruments and Methods in Physics Research A 392 (1997) 402-406 INSTRUMENTS

    E-Print Network [OSTI]

    Thompson, Chris

    1997-01-01

    Nuclear Instruments and Methods in Physics Research A 392 (1997) 402-406 NUCLEAR INSTRUMENTS _.z 6]. Other princi- pal shortcomings of PET are its considerable capital cost and limited availability. We

  6. Coupled flow and geomechanical analysis for gas production in the Prudhoe Bay Unit L-106 well Unit C gas hydrate deposit in Alaska

    E-Print Network [OSTI]

    Kim, J.

    2014-01-01

    way Coupled Fluid Flow and Geomechanics in Hydrate Deposits.for Coupled Flow and Geomechanics. Soc. Pet. Eng. J. 16(2):for coupled flow and geomechanics: Drained and undrained

  7. Radical reuse : from the superfluous to the exquisite

    E-Print Network [OSTI]

    Marraccini, Marco

    2006-01-01

    This thesis focuses on the systematic possibilities for the intricate architectural reuse and reconfiguration of the radial tire and the PET plastic bottle. Both waste products demonstrate significant structural and ...

  8. Submission Format for IMS2004 (Title in 18-point Times font)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    was performed with experimental tests of arc-faults in close proximity to three polymer materials common in PV systems, e.g., polycarbonate, PET, and nylon 6,6. Two polymer...

  9. ANTIMATTER'S GONE MISSING......

    E-Print Network [OSTI]

    -Emission Tomography (PET) scanners for medical imaging in hospi- tals. One day it might even be possible to use Enterprise? There is no possibility to use antimatter as an energy `source'. Unlike solar energy, coal or oil

  10. L-1 / S. P. Gorkhali We have developed a conformable-polymer dispersed liquid

    E-Print Network [OSTI]

    Cairns, Darran

    /PET substrates at room temperature, the display is then molded to conform to a particular template, heated above be analogous to `heat-shrink' in electronics? With such a technology, one could envision a number of new

  11. Rateless Code Based Multimedia Multicasting with Outage Probability Constraints

    E-Print Network [OSTI]

    Blostein, Steven D.

    Rateless Code Based Multimedia Multicasting with Outage Probability Constraints Wei Sheng, Wai encoding transmission (PET)-based packetization structure [1] combined with rateless codes. Outage is capable of minimizing the transmission cost while simultaneously guaranteeing outage prob- ability

  12. Spatially explicit load enrichment calculation tool and cluster analysis for identification of E. coli sources in Plum Creek Watershed, Texas 

    E-Print Network [OSTI]

    Teague, Aarin Elizabeth

    2009-06-02

    . Locations of contributing non-point and point sources in the watershed were defined using Geographic Information Systems (GIS). By distributing livestock, wildlife, wastewater treatment plants, septic systems, and pet sources, the bacterial load...

  13. Assessing Visuospatial Neglect in Children with Brain Injury 

    E-Print Network [OSTI]

    Wahlberg, Andrea Christine

    2014-05-28

    lead to overgeneralization of the neural basis of VSN (Ting et al., 2011). Brain imaging studies utilizing functional magnetic resonance imaging (fMRI), positron emission tomography (PET), perfusion weighted imaging (PWI), and diffusion 15...

  14. Functional lung imaging in humans using Positron Emission Tomography

    E-Print Network [OSTI]

    Layfield, Dominick, 1971-

    2003-01-01

    This thesis deals with a method of functional lung imaging using Positron Emission Tomography (PET). In this technique, a radioactive tracer, nitrogen-13, is dissolved in saline solution, and injected into a peripheral ...

  15. CX-001909: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    MRC Polyethylene Terephthalate (PET) Recycling FacilityCX(s) Applied: B5.1Date: 04/20/2010Location(s): Chicago, IllinoisOffice(s): Energy Efficiency and Renewable Energy, Golden Field Office

  16. Phase Structure and Properties of Poly(ethylene terephthalate)/High-Density Polyethylene Based on

    E-Print Network [OSTI]

    University of Science and Technology, Shanghai 200237, People's Republic of China Received 12 June 2008 words: polyethylene; recycling; blends; poly(ethylene terephthalate) INTRODUCTION Plastics account-density polyethylene (LDPE), polypropylene (PP), Poly (ethylene terephthalate) (PET), etc. The plastic waste

  17. Recent hybrid origin of three rare chinese turtles

    E-Print Network [OSTI]

    Stuart, Bryan L.; Parham, James F.

    2006-01-01

    Massachusetts, USA. van Dijk PP, Stuart BL, Rhodin AGJ,Tortoises in Asia (eds. van Dijk PP, Stuart BL, Rhodin AGJ),medicine, and pets (van Dijk et al. 2000), and now more than

  18. High Resolution Mapping of Enhancer-Promoter Interactions

    E-Print Network [OSTI]

    Reeder, Christopher

    RNA Polymerase II ChIA-PET data has revealed enhancers that are active in a profiled cell type and the genes that the enhancers regulate through chromatin interactions. The most commonly used computational method for ...

  19. The effect of machine and material parameters on rare earth roller separation

    E-Print Network [OSTI]

    Hu, Esther, S.B. Massachusetts Institute of Technology

    2009-01-01

    This study addresses the affect of machine and material factors on the separation of PET plastic and aluminum on the Rare Earth Roller magnetic separator. The purposes of this study are to gain a better understanding of ...

  20. Study of scattering in positron emission tomography 

    E-Print Network [OSTI]

    Aguiar, James

    1998-01-01

    The Texas A&M University positron emission tomograph (TAMU PET) is an experimental, medical-imaging instrument designed to detect gamma rays produced by positron-electron annihilation. Each annihilation yields two coincident gamma rays...

  1. Combined water use of turf and woody ornamentals in an irrigated South Texas landscape 

    E-Print Network [OSTI]

    Havlak, Roger Dale

    2004-01-01

    Landscape water conservation and potential evapotranspiration (PET or ET[p]) based irrigation programs are hindered by a lack of data on actual evapotranspiration (ET[a]) rates of multiple plant species landscapes. Irrigation coefficients...

  2. Triplet Acetylenes as Synthetic Equivalents of 1,2-Bicarbenes: Phantom n,* State Controls Reactivity in

    E-Print Network [OSTI]

    Alabugin, Igor

    [3.3.0.02,8 .04,6 ]octanes (homoquadricyclanes). In the case of pyrazinyl acetylenes, the primary acetylene: PET). Dramatically enhanced ISC between -* S1 state and "phantom" n,* triplet excited state

  3. Isochorismate Synthase Enzymes in Arabidopsis

    E-Print Network [OSTI]

    Strawn, Marcus Antoninus

    2010-01-01

    in: Strawn, M. A. , Marr, S. K. , Inoue, K. , Inada, N. ,these last five years. Sharon Marr was the best lab manager16 (obtained from Dr. Sharon Marr) is a pET-28 derivative

  4. Drivers of variability in water use of native and non-native urban trees in the greater Los Angeles area

    E-Print Network [OSTI]

    McCarthy, Heather R.; Pataki, Diane E.

    2010-01-01

    simulation of tree effects in an urban water balance model.J Am Water Resour Assn 44:75–85 White R, Havlak R, NationsD, Dewey D (2007) How much water is “enough”? Using PET to

  5. Nuclear Cardiology Objectives Understand the principles of myocardial perfusion and blood flow, factors

    E-Print Network [OSTI]

    Ford, James

    Nuclear Cardiology Objectives Knowledge · Understand the principles of myocardial perfusion in nuclear imaging, including collimation, resolution, contrast, localization, noise, ECT, SPECT, PET, image. · Know the differences between the various radioisotopes used in nuclear cardiology, including

  6. Dog Whisperer

    E-Print Network [OSTI]

    Hacker, Randi

    2013-05-22

    Broadcast Transcript: As we mentioned in an earlier Postcard, dogs have only recently become favored pets rather than favorite meals here in China. And, if you needed further proof of this transformation, here it is: Cesar Millan has been tapped...

  7. Iterative Solution of Global Electromagnetic Wavefields with Finite Elements

    E-Print Network [OSTI]

    Jaun, André

    memory savings, but it is also more efficient than a direct solution and paves the way implemented in the PetSc software library [23] and 2 #12; result in considerable memory savings and should

  8. BRADFORD COUNTY DEPARTMENT OF EMERGENCY MANAGEMENT

    E-Print Network [OSTI]

    Hill, Jeffrey E.

    of sunlight is weak. DRESS ­ Wear clothing that covers most of your skin when outdoors. DEET ­ Repellents collect water. Pump out bilges on boats. Replace water in birdbaths and pet dishes at least once a week

  9. Flexible and transparent supercapacitor based on In2O3 nanowire/carbon nanotube heterogeneous films

    E-Print Network [OSTI]

    Zhou, Chongwu

    which may find applications in heads-up display, automobile wind-shield display, and conformable and then released it onto a polyethylene terephtalate PET substrate on hotplate at 100 °C. The scanning electron mi

  10. Springtails 

    E-Print Network [OSTI]

    Merchant, Michael E.; Muegge, Mark A.

    2004-07-16

    Springtails are an insect pest of lawns and homes. They are not harmful to people, pets, plants, structures or furnishings. However, their presence and jumping behaviors make them a nuisance. This publication offers ideas for controlling them....

  11. Addiction Studies with Positron Emission Tomography

    ScienceCinema (OSTI)

    Joanna Fowler

    2010-01-08

    Brookhaven scientist Joanna Fowler describes Positron Emission Technology (PET) research at BNL which for the past 30 years has focused in the integration of basic research in radiotracer chemistry with the tools of neuroscience to develop new scientific

  12. Fermilab Today

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hollywood Palms Employee Appreciation Day For more discounts, visit the employee discount Web page. In the News Crunch time for pet theory on dark matter From Nature, Jan. 21, 2015...

  13. Orthopaedic Implant & Imaging Laboratory Our laboratory is dedicated to exploring the

    E-Print Network [OSTI]

    Berdichevsky, Victor

    on tissue biocompatibility Composite of polymetric, metallic and ceramic materials with drug loading coating with nanoceramic matrix for controlled drug release Molecular and Cellular Imaging PET/CT Imaging

  14. March 2015 Most Viewed Documents for Biology And Medicine | OSTI...

    Office of Scientific and Technical Information (OSTI)

    5 Most Viewed Documents for Biology And Medicine Measuring dopamine release in the human brain with PET Volkow, N.D. Brookhaven National Lab., Upton, NY (United States)|State...

  15. Health and Safety Committee 10 Meeting July 21, 2014

    E-Print Network [OSTI]

    MacCready, Parker

    of the meeting `Transportation on Campus' with a focus of bikes and pedestrians. EA explains the Step Smart to unplug and make eye contact to avoid accidents. EA reports of bikes and pets inside buildings

  16. Development of integrated imaging techniques for investigating biomarkers in glioblastoma

    E-Print Network [OSTI]

    Kim, Heisoog

    2011-01-01

    Cancer is a diverse disease with many manifestations. Various imaging modalities including magnetic resonance imaging (MRI) and positron emission tomography (PET) have been used to study human cancer. In this study, we ...

  17. u. S. Department of the Inter ior, Osee. r L: Che.pman, Secretary Fish and Wildlife Service, Albert ~. Day, Director

    E-Print Network [OSTI]

    .....................................................Abstract Introduct ion ................................................. ut ilization of Fish Waste ..........................................................................Food for Hatchery Fish Food for Fur Farm Animals ................................. Pet Foods of the Inst itute of Food Teohnologists, San Franoisco, California, July 12, 1949· ·* Chemist, Fishery

  18. MINORS 5/30/2014 College Minor Code Description

    E-Print Network [OSTI]

    Ginzel, Matthew

    Plant Pathology Agriculture PTFD Pet Food Processing Agriculture SOIL Soil Science Agriculture SUEV Science MATH Mathematics Science PHYS Physics Science STAT Statistics Technology BCMT Building Const Mgmt Tech Technology OLSV Organizational Leadership Technology CNGR Construction Graphics Technology CNIT

  19. QUANTITATIVE ANALYSIS OF MASTICATORY PERFORMANCE IN VERTEBRATES

    E-Print Network [OSTI]

    Krovi, Venkat

    technology and image processing techniques were used to obtain CAD model of a skull and mandible of a bulldog in the development of new pet foods. We also examine the use of a robotic solution where a generic parallel

  20. Molecular Imaging in Cancer 3A AACR/SNMMI State-of-the-Art Molecular Imaging in

    E-Print Network [OSTI]

    Sridhar, Srinivas

    on Wednesday, including "Imaging Therapeutic Response with PET," "Emerging Technologies," and "In Vivo Studies to discuss the latest developments in imaging genetic and molecular processes of cancer as they occur

  1. MINORS 5/20/2013 College Minor Code Description

    E-Print Network [OSTI]

    Holland, Jeffrey

    &Envrmtl Sci Agriculture PLBI Plant Biology Agriculture PLTP Plant Pathology Agriculture PTFD Pet Food Processing Agriculture SOIL Soil Science Agriculture SUEV Sustainable Environments Agriculture UFOR Urban Physics Science STAT Statistics Technology BCMT Building Const Mgmt Tech Technology OLSV Organizational

  2. Can medial temporal lobe regions distinguish true from false? An event-related functional MRI study

    E-Print Network [OSTI]

    Wagner, Anthony

    and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139; and ¶Department, possibly reflecting semantic processing. Precuneus and lat- eral parietal regions were more activated. For example, a positron emission tomography (PET) study found that MTL activity during object recognition

  3. Page 1 of 4 Please complete the following in full

    E-Print Network [OSTI]

    Martin, Jeff

    on the Province to assist us in our decision-making process. The Department of Energy, Science & Technology Emission Tomography (PET) Lab at Health Sciences Centre (HSC). The research also relates to the strategic

  4. Institut for Mekanik, Energi og Konstruktion ved Danmarks Tekniske Universitet (DTU-MEK)

    E-Print Network [OSTI]

    : "Kompositte Letvægtskonstruktioner" 7. November 2006 MANUFACTURING TECHNOLOGY FOR ADVANCED FIBRE COMPOSITES Terephthalate ­ PET · Polyamide ­ PA · Polypropylene ­ PP · Polyethylene - PE Semi crystalline Amorphous at fracture · Potential for fast processing · Ultimate shelf life · Clean working environment · Potential

  5. http://shrp.umdnj.edu/online courses/online06 tech support.htm A D V A N C E D I M A G I N G

    E-Print Network [OSTI]

    Cheng, Mei-Fang

    combines chemistry, physics, mathematics, computer technology, and medicine in using radioactivity Emission Computed Tomography or PET scan- ning is also incorporated into the field of nuclear medicine processing and image enhancement · Analyze biologic specimens in the laboratory · Provide images, data

  6. Organoboranes as 18F Fluoride Anion Captors 

    E-Print Network [OSTI]

    Chansaenpak, Kantapat

    2015-07-29

    Fluorine-18 (18F) is the most frequently used radionuclide in positron emission tomography (PET). This is, in part, due to the fact that fluorine is the element that is prevalent in organic molecules as well as easy to ...

  7. RIKEN Research Cluster for Innovation Collaborations Division

    E-Print Network [OSTI]

    Fukai, Tomoki

    Laboratory Measurement Information Laboratory Radiant Energy and Electric Generation Laboratory Novel PET Diagnostics Laboratory High Efficiency UV-LED Laboratory Ultra-Sensitive Biomolecule Detection Laboratory Optoelectronic Device Research Laboratory Hybrid Laser Research Laboratory Transporter-Based Prediction of Drug

  8. SGM : News : Previous News Stories http://www.sgm.ac.uk/news/newsmonths/september04.cfm 1 of 6 8/9/06 10:56 AM

    E-Print Network [OSTI]

    Gardner, Andy

    cause infertility. This means that teenage girls are 43% more likely to be infected than those aged 20 preventative treatment. People who believe they or their pets may have had contact with the animal should get

  9. GMP Compliance for Pharmaceutical Excipients in the Glycerin Industry

    E-Print Network [OSTI]

    Elliot, Christina

    2008-12-19

    in which a Chinese pet food manufacturer exported wheat gluten containing an industrial chemical melamine, which then resulted in pet deaths in the United States (New York Times 6 May 2007). There have also been cases in which toys from Chinese... control program is needed to keep the facility free of bugs and rodents. Guidelines should be established and followed for computer systems, utilities, water, air handling, - 13 - controlled environments, lighting, drainage, and washing...

  10. L-[METHYL-{sup 11}C] Methionine Positron Emission Tomography for Target Delineation in Malignant Gliomas: Impact on Results of Carbon Ion Radiotherapy

    SciTech Connect (OSTI)

    Mahasittiwat, Pawinee; Mizoe, Jun-etsu Hasegawa, Azusa; Ishikawa, Hiroyuki; Yoshikawa, Kyosan; Mizuno, Hideyuki; Yanagi, Takeshi; Takagi, Ryou D.D.S.; Pattaranutaporn, Pittayapoom; Tsujii, Hirohiko

    2008-02-01

    Purpose: To assess the importance of {sup 11}C-methionine (MET)-positron emission tomography (PET) for clinical target volume (CTV) delineation. Methods and Materials: This retrospective study analyzed 16 patients with malignant glioma (4 patients, anaplastic astrocytoma; 12 patients, glioblastoma multiforme) treated with surgery and carbon ion radiotherapy from April 2002 to Nov 2005. The MET-PET target volume was compared with gross tumor volume and CTV, defined by using computed tomography/magnetic resonance imaging (MRI). Correlations with treatment results were evaluated between positive and negative extended volumes (EVs) of the MET-PET target for CTV. Results: Mean volumes of the MET-PET targets, CTV1 (defined by means of high-intensity volume on T2-weighted MRI), and CTV2 (defined by means of contrast-enhancement volume on T1-weighted MRI) were 6.35, 264.7, and 117.7 cm{sup 3}, respectively. Mean EVs of MET-PET targets for CTV1 and CTV2 were 0.6 and 2.2 cm{sup 3}, respectively. The MET-PET target volumes were included in CTV1 and CTV2 in 13 (81.3%) and 11 patients (68.8%), respectively. Patients with a negative EV for CTV1 had significantly greater survival rate (p = 0.0069), regional control (p = 0.0047), and distant control time (p = 0.0267) than those with a positive EV. Distant control time also was better in patients with a negative EV for CTV2 than those with a positive EV (p = 0.0401). Conclusions: For patients with malignant gliomas, MET-PET has a possibility to be a predictor of outcome in carbon ion radiotherapy. Direct use of MET-PET fused to planning computed tomography will be useful and yield favorable results for the therapy.

  11. HV Plateau PM6591 Run 138 LED 98/03/02 21.20 750 100012501500

    E-Print Network [OSTI]

    8 10 12 14 16 18 20 p [GeV] Q C [rad] p p e e K K p p Aerogel, n=1.03 C 4 F 10 , n=1.0014 µ Standard finish ­ Al coating Standard finish ­ UV280 coating Optimal finish Ag­PET foil SS­Ag­PET foil Alu ) 4 10 2 AEROGEL(SIO ) and

  12. Controlling Fleas 

    E-Print Network [OSTI]

    Merchant, Michael E.; Robinson, James V.

    2006-12-18

    . For this reason, avoid close contact with wild rodents such as squirrels, rats and prairie dogs. Their fleas can bite you and may transmit disease. Cat fleas, however, do not carry plague. Control An integrated flea control program includes good sanitation... and treatment of the pet and environment. You can eliminate fleas from your home with proper treatment, but it may take time, especially if the infes- tation is heavy. Sanitation. Change pet bedding regularly and vacuum thoroughly. Vacuuming removes up to 30...

  13. Impact of [{sup 18}F] Fluorodeoxyglucose Positron Emission Tomography on Staging and Management of Early-Stage Follicular Non-Hodgkin Lymphoma

    SciTech Connect (OSTI)

    Wirth, Andrew Foo, Marcus; Seymour, John F.; MacManus, Michael P.; Hicks, Rodney J.

    2008-05-01

    Purpose: Accurate staging is critical to select patients with early-stage (I-II) follicular lymphoma (ESFL) suitable for involved-field radiotherapy (IFRT) and to define the radiotherapy portal. We evaluated the impact of fluorodeoxyglucose (FDG) PET on staging, treatment, and outcome for patients with ESFL on conventional staging. Methods and Materials: Forty-two patients with untreated ESFL (World Health Organization Grade I-IIIa, or 'low grade') following a minimum of physical examination, computerized tomography, and bone marrow examination (conventional assessment) and who had staging PET from June 1997 to June 2006 were studied retrospectively. Stage allocation was based on routine imaging reports. Disease sites, stage, and management plan were recorded based on conventional assessment or conventional assessment plus PET. Results: FDG avidity was demonstrated in 97% of patients in whom disease was evident on conventional assessment after biopsy. PET findings suggested a change of stage or management in 19 patients: 13 (31%) who were upstaged to Stage III-IV, altering ideal management from IFRT to systemic therapy, and 6 (14%) who had the involved field enlarged, including 4 upstaged from Stage I to II. Of these 19 cases, PET findings were considered true positive in 8 patients, indeterminate in 10, and false positive in only 1 patient. Conclusions: Our data confirm that ESFL is usually FDG-avid. In routine practice, PET has the potential to upstage and thereby alter management in a high proportion of patients with apparent ESFL.

  14. SU-E-J-148: Evaluating Tumor Response with a Commercially Available Deformable Registration System

    SciTech Connect (OSTI)

    Bowling, J; Ramsey, C [Thompson Cancer Survival Center, Knoxville, TN (United States)

    2014-06-01

    Purpose: The purpose of this study is to present a method for evaluating the response to treatment using a commercially available deformable image registration software package (Velocity Medical Systems) and repeat PET/CT imaging. This technique can be used to identify volumes that are risk for tumor recurrence. Methods: Response to treatment was evaluated using PET/CT images acquired prior-to and post-treatment for radiation therapy patients treated with concurrent chemotherapy. Velocity (Version 3.0.1) was used to deform the initial PET/CT to the post treatment PET/CT. The post-treatment PET images were then subtracted from the pre-treatment PET images. The resulting re-sampled image is a three-dimensional SUV difference map that shows pixels with increasing SUV values. SUV values increases greater than 2.5 in the post treatment images were identified for additional follow-up. Results: A total of 5 Lung patients were analyzed as part of this study. One lung patient in the cohort had an SUV increase of +3.28 that was identified using the SUV difference map. This volume of increased uptake was located outside the treatment field and adjacent to the 35 Gy isodose line. The remaining four patients all had SUV decreases inside the planning target volume, and no unexpected areas of increase outside the irradiated volumes. All five patients were analyzed using standard tools inside the Velocity application. Conclusion: The response to treatment can easily be measured using serial PET/CT images and a commercially available deformable image registration. This provides both the radiation oncologists and medical oncologists with a quantitative assessment of their treatment to use in patient follow-up.

  15. Amorphous silicon detectors in positron emission tomography

    SciTech Connect (OSTI)

    Conti, M. (Istituto Nazionale di Fisica Nucleare, Pisa (Italy) Lawrence Berkeley Lab., CA (USA)); Perez-Mendez, V. (Lawrence Berkeley Lab., CA (USA))

    1989-12-01

    The physics of the detection process is studied and the performances of different Positron Emission Tomography (PET) system are evaluated by theoretical calculation and/or Monte Carlo Simulation (using the EGS code) in this paper, whose table of contents can be summarized as follows: a brief introduction to amorphous silicon detectors and some useful equation is presented; a Tantalum/Amorphous Silicon PET project is studied and the efficiency of the systems is studied by Monte Carlo Simulation; two similar CsI/Amorphous Silicon PET projects are presented and their efficiency and spatial resolution are studied by Monte Carlo Simulation, light yield and time characteristics of the scintillation light are discussed for different scintillators; some experimental result on light yield measurements are presented; a Xenon/Amorphous Silicon PET is presented, the physical mechanism of scintillation in Xenon is explained, a theoretical estimation of total light yield in Xenon and the resulting efficiency is discussed altogether with some consideration of the time resolution of the system; the amorphous silicon integrated electronics is presented, total noise and time resolution are evaluated in each of our applications; the merit parameters {epsilon}{sup 2}{tau}'s are evaluated and compared with other PET systems and conclusions are drawn; and a complete reference list for Xenon scintillation light physics and its applications is presented altogether with the listing of the developed simulation programs.

  16. Tumor Volume Combined With Number of Positive Lymph Node Stations Is a More Important Prognostic Factor Than TNM Stage for Survival of Non-Small-Cell Lung Cancer Patients Treated With (Chemo)radiotherapy

    SciTech Connect (OSTI)

    Dehing-Oberije, Cary [Department of Radiotherapy, University Hospital Maastricht, University Maastricht, MAASTRO Clinic, Research Institute Growth and Development (GROW), Maastricht (Netherlands)], E-mail: cary.dehing@maastro.nl; Ruysscher, Dirk de; Weide, Hiska van der [Department of Radiotherapy, University Hospital Maastricht, University Maastricht, MAASTRO Clinic, Research Institute Growth and Development (GROW), Maastricht (Netherlands); Hochstenbag, Monique [Department of Pulmonology, University Hospital Maastricht, Maastricht (Netherlands); Bootsma, Gerben [Department of Pulmonology, Atrium Medical Centre, Heerlen (Netherlands); Geraedts, Wiel [Department of Pulmonology, Maasland Hospital, Sittard (Netherlands); Pitz, Cordula [Department of Pulmonology, Laurentius Hospital, Roermond (Netherlands); Simons, Jean [Department of Pulmonology, Sint Jans Hospital, Weert (Netherlands); Teule, Jaap [Department of Nuclear Medicine, University Hospital Maastricht, Maastricht (Netherlands); Rahmy, Ali [Department of Nuclear Medicine, Atrium Medical Centre, Heerlen (Netherlands); Thimister, Paul [Department of Nuclear Medicine, Maasland Hospital, Sittard (Netherlands); Steck, Harald [Siemens Medical Solutions, Malvern, PA (United States); Lambin, Philippe [Department of Radiotherapy, University Hospital Maastricht, University Maastricht, MAASTRO Clinic, Research Institute Growth and Development (GROW), Maastricht (Netherlands)

    2008-03-15

    Purpose: The current tumor, node, metastasis system needs refinement to improve its ability to predict survival of patients with non-small-cell lung cancer (NSCLC) treated with (chemo)radiation. In this study, we investigated the prognostic value of tumor volume and N status, assessed by using fluorodeoxyglucose-positron emission tomography (PET). Patients and Methods: Clinical data from 270 consecutive patients with inoperable NSCLC Stages I-IIIB treated radically with (chemo)radiation were collected retrospectively. Diagnostic imaging was performed using either integrated PET-computed tomography or computed tomography and PET separately. The Kaplan-Meier method, as well as Cox regression, was used to analyze data. Results: Univariate survival analysis showed that number of positive lymph node stations (PLNSs), as well as N stage on PET, was associated significantly with survival. The final multivariate Cox model consisted of number of PLNSs, gross tumor volume (i.e., volume of the primary tumor plus lymph nodes), sex, World Health Organization performance status, and equivalent radiation dose corrected for time; N stage was no longer significant. Conclusions: Number of PLNSs, assessed by means of fluorodeoxyglucose-PET, was a significant factor for survival of patients with inoperable NSCLC treated with (chemo)radiation. Risk stratification for this group of patients should be based on gross tumor volume, number of PLNSs, sex, World Health Organization performance status, and equivalent radiation dose corrected for time.

  17. An XPS study on the chemical bond structure at the interface between SiO{sub x}N{sub y} and N doped polyethylene terephthalate

    SciTech Connect (OSTI)

    Ding Wanyu [School of Materials Science and Engineering, Dalian Jiaotong University, Dalian 116028 (China); Key Laboratory of Materials Modification by Laser, Ion and Electron Beams, Ministry of Education, Dalian University of Technology, Dalian 116024 (China); Li Li; Zhang Lina; Chai Weiping [School of Materials Science and Engineering, Dalian Jiaotong University, Dalian 116028 (China); Ju Dongying [Department of Material Science and Engineering, Saitama Institute of Technology, Fukaya 369-0293 (Japan); Peng Shou [China Triumph International Engineering Co., Ltd., 2000 Zhongshanbei Road, 200063 Shanghai (China)

    2013-03-14

    The super-thin silicon oxynitride (SiO{sub x}N{sub y}) films were deposited onto the N doped polyethylene terephthalate (PET) surface. Varying the N doping parameters, the different chemical bond structures were obtained at the interface between the SiO{sub x}N{sub y} film and the PET surface. X-ray photoelectron spectra results showed that at the initial stage of SiO{sub x}N{sub y} film growth, the C=N bonds could be broken and C-N-Si crosslink bonds could be formed at the interface of SiO{sub x}N{sub y}/PET, which C=N bonds could be formed onto the PET surface during the N doping process. At these positions, the SiO{sub x}N{sub y} film could be crosslinked well onto the PET surface. Meanwhile, the doped N could crosslink the [SiO{sub 4}] and [SiN{sub 4}] tetrahedrons, which could easily form the dense layer structure at the initial stage of SiO{sub x}N{sub y} film growth, instead of the ring and/or chain structures of [SiO{sub 4}] tetrahedrons crosslinked by O. Finally, from the point of applying SiO{sub x}N{sub y}/PET complex as the substrate, the present work reveals a simple way to crosslink them, as well as the crosslink model and physicochemical mechanism happened at the interface of complex.

  18. MO-C-BRE-01: The WMIS-AAPM Joint Symposium: Advances in Molecular Imaging

    SciTech Connect (OSTI)

    Contag, C; Pogue, B; Lewis, J

    2014-06-15

    This joint symposium of the World Molecular Imaging Society (WMIS) and the AAPM includes three luminary speakers discussing work in new paradigms of molecular imaging in cancer (Contag), applications of optical imaging technologies to radiation therapy (Pogue) and an update on PET imaging as a surrogate biomarker for cancer progression and response to therapy. Learning Objectives: Appreciate the current trends in molecular and systems imaging. Understand how optical imaging technologies, and particularly Cerenkov detectors, can be used in advancing radiation oncology. Stay current on new PET tracers - and targets - of interest in cancer treatment.

  19. Pretreatment Staging Positron Emission Tomography/Computed Tomography in Patients With Inflammatory Breast Cancer Influences Radiation Treatment Field Designs

    SciTech Connect (OSTI)

    Walker, Gary V.; Niikura, Naoki; Yang Wei; Rohren, Eric; Valero, Vicente; Woodward, Wendy A.; Alvarez, Ricardo H.; Lucci, Anthony; Ueno, Naoto T.; Buchholz, Thomas A.

    2012-08-01

    Purpose: Positron emission tomography/computed tomography (PET/CT) is increasingly being utilized for staging of inflammatory breast cancer (IBC). The purpose of this study was to define how pretreatment PET/CT studies affected postmastectomy radiation treatment (PMRT) planning decisions for IBC. Methods and Materials: We performed a retrospective analysis of 62 patients diagnosed with IBC between 2004 and 2009, who were treated with PMRT in our institution and who had a staging PET/CT within 3 months of diagnosis. Patients received a baseline physical examination, staging mammography, ultrasonographic examination of breast and draining lymphatics, and chest radiography; most patients also had a bone scan (55 patients), liver imaging (52 patients), breast MRI (46 patients), and chest CT (25 patients). We compared how PET/CT findings affected PMRT, assuming that standard PMRT would target the chest wall, level III axilla, supraclavicular fossa, and internal mammary chain (IMC). Any modification of target volumes, field borders, or dose prescriptions was considered a change. Results: PET/CT detected new areas of disease in 27 of the 62 patients (44%). The areas of additional disease included the breast (1 patient), ipsilateral axilla (1 patient), ipsilateral supraclavicular (4 patients), ipsilateral infraclavicular (1 patient), ipsilateral IMC (5 patients), ipsilateral subpectoral (3 patients), mediastinal (8 patients), other distant/contralateral lymph nodes (15 patients), or bone (6 patients). One patient was found to have a non-breast second primary tumor. The findings of the PET/CT led to changes in PMRT in 11 of 62 patients (17.7%). These changes included additional fields in 5 patients, adjustment of fields in 2 patients, and higher doses to the supraclavicular fossa (2 patients) and IMC (5 patients). Conclusions: For patients with newly diagnosed IBC, pretreatment PET/CT provides important information concerning involvement of locoregional lymph nodes, mediastinal lymph nodes, and unsuspected sites of distant metastasis. This information is important in the design of radiotherapy treatment fields and, therefore, we recommend that PET/CT be a component of initial staging for IBC.

  20. Life Cycle Inventory of CO2 in a EOR System Supporting Information

    E-Print Network [OSTI]

    Jaramillo, Paulina

    /MJ) Combustion (g CO2e/MJ) Coal [1] 4.99 88 LPG-NGL [2, 3] 17.5 58.4 Pet-Coke [2, 3] 17.5 95.9 Other Pet Natural Gas (m3/bbl) 7.08 Coal (metric ton/bbl) 6.3-06 Electricity (kWh/bbl) 7.6 LPG (bbl/bbl) 4.8E-04-04 Petroleum Coke (bbl/bbl) 1.6E-02 Results Figure S1 shows the sources of these emissions

  1. Alternate Applications of Fusion - Production of Radioisotopes

    SciTech Connect (OSTI)

    Kulcinski, G.L.; Weidner, J.; Cipiti, B.; Ashley, R.P.; Santarius, J.F.; Murali, S.K.; Piefer, G.; Radel, R. [University of Wisconsin-Madison (United States)

    2003-09-15

    A major effort to find near-term, non-electric applications of fusion energy has shown that the production of radioisotopes is attractive. The use of the D{sup 3}He fusion reaction to produce Positron Emission Tomography (PET) isotopes is described. An Inertial Electrostatic Confinement (IEC) device is particularly well suited to produce low levels of high-energy (14.7 MeV) protons, which in turn, can produce short-lived PET isotopes. The IEC device at University of Wisconsin has been modified to investigate the potential of this process to be commercially attractive.

  2. New Barrier Coating Materials for PV Module Backsheets: Preprint

    SciTech Connect (OSTI)

    Barber, G. D.; Jorgensen, G. J.; Terwilliger, K.; Glick, S. H.; Pern, J.; McMahon, T. J.

    2002-05-01

    This conference paper describes the high moisture barrier high resistivity coatings on polyethylene terepthalate (PET) have been fabricated and characterized for use in PV module back sheet applications. These thin film barriers exhibit water vapor transmission rates (WVTR) as low as 0.1 g/m2-day at 37.8 C and have shown excellent adhesion (> 10 N/mm) to both ethylene vinyl acetate (EVA) and PET even after filtered xenon arc lamp UV exposure. The WVTR and adhesion values for this construction are compared to and shown to be superior to candidate polymeric backsheet materials.

  3. Analyse en moyenne de probl`emes NP-complets : pourquoi tant d'algorithmes

    E-Print Network [OSTI]

    Marckert, Jean-François

    . The Swede keeps dogs as pets. 3. The Dane drinks tea. 4. The green house is on the left of the white house) in 5 different colors: blue, green, red, white and yellow. 2. In each house lives a person: beer, coffee, milk, tea and water, smoke a certain brand of cigar: Blue Master, Dunhill, Pall Mall

  4. Lifestyle practices and pro-environmental technology Jonn Axsen a,

    E-Print Network [OSTI]

    toward adopting and using new pro-environmental technologies (PETs), namely electric vehicles, solar panels, and a green electricity program. We build a con- ceptual framework from lifestyle theory, where only. Non-green "techies" only report interest in solar panels, while "traditionalists" report

  5. km on Lake Tanganyika (Fig. 2C). Single airguns or multigun arrays in the size range of40 to 140 cubic

    E-Print Network [OSTI]

    Richardson, David

    these rift sediments to be Cenozoic in age. 10. Sequence boundaries are the unconformities and their correlative conformities that define deposition- al sequences. A review of the concepts of sequence stratigraphy is presented in C. E. Payton, Ed., Am. Assoc. Pet. Geol. Mem. 26 (1977). 11. T. J. Dunkelman, J. A

  6. ASSOCIATE OF SCIENCE IN PETROLEUM TECHNOLOGY (Suggested 2 Year Plan)

    E-Print Network [OSTI]

    Benos, Panayiotis "Takis"

    FIRST YEAR, 2ND TERM CREDITS ENG 0101 English Composition I 3 ENG 0102 English Composition II 3 PET 0101 Per Term 3 Total Credits Per Academic Year 34 SECOND YEAR, 1ST TERM CREDITS SECOND YEAR, 2ND TERMASSOCIATE OF SCIENCE IN PETROLEUM TECHNOLOGY (Suggested 2 Year Plan) FIRST YEAR, 1ST TERM CREDITS

  7. Quantification of the precipitation loss of radiation belt electrons observed by SAMPEX

    E-Print Network [OSTI]

    Li, Xinlin

    Click Here for Full Article Quantification of the precipitation loss of radiation belt electrons/PET observations, the rates and the spatial and temporal variations of electron loss to the atmosphere in the Earth and pitch angle diffusion. The measured electrons by SAMPEX can be distinguished as trapped, quasi trapped

  8. Indoor Air Quality Poor indoor air quality comes from many sources. It can lead to having

    E-Print Network [OSTI]

    Indoor Air Quality Fact Sheet Poor indoor air quality comes from many sources. It can lead Indoor Air Pollutants · Molds · Pollen · Dander from pet fur · Secondhand smoke · Formaldehyde · Carbon such as cleaners and pesticides How to Improve Indoor Air Quality · Open windows when you can to let in fresh air

  9. Dorin, A., "Artifact & Artifice : Building Artificial Life for Play", in Artificial Life, Vol. 10, No. 1, MIT Press, 2004, pp99-112

    E-Print Network [OSTI]

    Dorin, Alan

    systems in order to economically construct their simulacra. This paper examines a number of life-like toys; virtual pet; toy. 1.0 Introduction As children we may have played with plastic farm animals, toy soldiers, talking or crying dolls, wind-up beetles or battery operated robots. Today's children laser-blast virtual

  10. Research Article Received: 14 March 2012 Revised: 25 June 2012 Accepted: 26 June 2012 Published online in Wiley Online Library: 6 September 2012

    E-Print Network [OSTI]

    North Texas, University of

    degradation is slow ­ hence recycling is important.9,10 Among polymers manufactured in large quantities fairly polyurethane foams based on recycled poly(ethylene terephthalate) for oil sorption Ayman M. Atta,a,b Witold,b and Jose M. Perezc Abstract In using recycled poly(ethylene terephthalate) (PET) as a petroleum sorbent we

  11. Industry Symposium on Micro and Nano scale Cellular Polymers Department of Mechanical Engineering

    E-Print Network [OSTI]

    Kumar, Vipin

    .00 Gas-Assisted Thermoforming of Recycled PET Stephen Probert and Krishna Nadella 11.30 Porous PolymersIndustry Symposium on Micro and Nano scale Cellular Polymers Department of Mechanical Engineering, College of Engineering Professor Mark Tuttle, Chair, ME 8.30 State of Art of Microcellular Polymers Prof

  12. TEXASA&MUNIVERSITYEMERGENCYMANAGEMENT OFFICEOFSAFETYANDSECURITY

    E-Print Network [OSTI]

    known as the "urban heat island effect." Pets, horses, and livestock are also susceptible&MUNIVERSITYEMERGENCYMANAGEMENT OFFICEOFSAFETYANDSECURITY Why talk about excessive heat? In recent years, excessive heat has caused more deaths than all heat kills more than 1,000 people each year. During the July 1995 heat wave in Chicago, more than 700

  13. BACK TO BASICS: YOUR KEYS TO SAFE

    E-Print Network [OSTI]

    Kirschner, Denise

    BACK TO BASICS: YOUR KEYS TO SAFE DRIVING BUCKLE UP! Seat belts should never have time off DRIVE the back seat to the front seat.4 ·The back is the best place for pets. According to AAA, similar. Never place the shoulder portion under your arm or behind your back! ·Drivers should sit with at least

  14. See footnotes on back. NMSU PPO_500_01/01/13 NMSU DSU Customer Service: 1-866-369-NMSU (6678)

    E-Print Network [OSTI]

    Nishiguchi, Michele

    See footnotes on back. NMSU PPO_500_01/01/13 NMSU DSU Customer Service: 1-866-369-NMSU (6678) New 40% 4 Lab, X-Ray, MRI, CT Scan, PET Scan and Basic Diagnostic Tests 25% 4 40% 4 * A Primary Preferred

  15. After nearly a year and a half of construction, the Veterinary

    E-Print Network [OSTI]

    Arnold, Jonathan

    After nearly a year and a half of construction, the Veterinary Medical Learning Center is well for teaching and continuing education courses. We are currently on schedule to complete construction in early Adds Treatment Option...2 2014 Picture Your Pet Photo Contest...3 Construction Update...5 Take

  16. 09/12/2007 08:18 PMLife's Ingredients May Have 'Sprinkled' on Earth -Yahoo! News Page 1 of 4http://news.yahoo.com/s/space/20070911/sc_space/lifesingredientsmayhavesprinkledonearth

    E-Print Network [OSTI]

    Glaser, Rainer

    square foot of space, but over millions of years, enough could have accumulated to help make way for life planets as the stars they orbit travel through a galaxy. "There may be only a few molecules of adenine per Space & Astronomy Animals & Pets Dinosaurs & Fossils Biotech Energy Environment Search: All News Search

  17. COBEQUID TRAIL SALMON RIVER

    E-Print Network [OSTI]

    Lotze, Heike K.

    mini farmers market where several family vendors, All Sauced Up, Creative Artistry, Tucan Olive Oil or stuffed animal for some medical attention and enjoy the busy crafts table. Learn about how to keep your pets safe. Plant Oil for Fish Food? This interactive exhibit explores using camelina in fish diets

  18. Long-Term Feasibility of Agriculture in Zambia

    E-Print Network [OSTI]

    Petta, Jason

    Temperature Radiation from the Sun Rain 2 #12;Types of Evapotranspiration Reference evapotranspiration (ET0 life. Calculated similarly to PET but with a different KC #12;The Crop Coefficient Model 3 #12;Map 4 #12;P(failure) vs. Coefficient of Variation Data used: Shortwave radiation: 400 W m-2 Longwave

  19. harvestingf o r H o m e o w n e r s CLEMSONP U B L I C S E R V I C E

    E-Print Network [OSTI]

    Stuart, Steven J.

    downhill and picking up pollutants that are left behind on the landscape. These pollutants include soil, litter (like cigarette butts) fertilizers, pet waste, yard debris, oils and many other contaminants and built houses that came standard with a rainwater capture feature. When it rains, it pours... Stormwater

  20. SPE-139032-PP Field Development Strategies for Bakken Shale Formation

    E-Print Network [OSTI]

    Mohaghegh, Shahab

    rial doe s n ot n ece ssa ri ly refle ct a n y po sitio n of th e So ciet y o f Pet role um E ngine ers was generated, history matched and economical analysis for some proposed new wells is performed. Introduction

  1. A Method for Measurement of 3-Bromotyrosine Concentrations in Canine Serum and Its Clinical Application 

    E-Print Network [OSTI]

    Sattasathuchana, Panpicha

    2014-10-30

    in canine serum, (2) establish a reference interval for serum 3-BrY concentrations in healthy pet dogs, (3) determine the short-term stability of canine serum 3-BrY concentrations, and (4) evaluate the clinical usefulness of measuring 3-BrY concentrations...

  2. It's important to prepare for possible disasters and other

    E-Print Network [OSTI]

    Wright, Dawn Jeannine

    in case you must evacuate. · Water--one gallon per person, per day (3-day supply for evacuation, 2-week for children · Pet supplies (collar, leash, ID, food, carrier, bowl) · Two-way radios · Extra set of car keys you would respond if they were deployed. Plan what to do in case you are separated during an emergency

  3. Comparing the performance of a set of global chemistry-transport models for the West African region highlights the diverse behavior exhibited for convective uplift, advective

    E-Print Network [OSTI]

    Hourdin, Chez Frédéric

    radiation in the tropics results in a highly active chemical regime, which determines the atmospheric multimodel interComparison projeCt by Jason Edward williams, rinus schEElE, PEtEr van vElthovEn, idir bouarar

  4. Transition Ceremony Congratulations to the Class of 2016 on their successful

    E-Print Network [OSTI]

    's Research Hospital. House Officer Seminar Camilla Jamieson, DVM, will present "Neonatal Alloimune Disease Development. Hosting the competition for the second year, a total of 12 teams competed. Congratulations. Veterinary Voices Seminar Dr. Joao Brandao will present "Pet birds: how to provide the best environment

  5. 453rd Brookhaven Lecture

    ScienceCinema (OSTI)

    Richard Ferrieri

    2010-09-01

    In this lecture titled "Striving Towards Energy Sustainability: How Will Plants Play a Role in Our Future?" Richard Ferrieri discusses how radiotracers and positron emission tomography (PET imaging) are providing a new look into plant processes that could lead to more renewable biofuels.

  6. Oil and Gas CDT Bots in Rocks: Intelligent Rock Deformation for Fault Rock

    E-Print Network [OSTI]

    Henderson, Gideon

    Heriot-Watt University, Institute of Petroleum Engineering Supervisory Team · Dr Helen Lewis, Heriot://www.pet.hw.ac.uk/staff-directory/jimsomerville.htm Key Words Nano/Micro sensors; faults; fault zones; geomechanics; rock mechanics; rock deformation-deformed equivalent, a different lab-deformed example and a geomechanical simulation of a fault zone showing permanent

  7. Effects of storage temperature and duration on release of antimony and bisphenol A from polyethylene terephthalate drinking water

    E-Print Network [OSTI]

    Ma, Lena

    polyethylene terephthalate drinking water bottles of China Ying-Ying Fan a , Jian-Lun Zheng a , Jing-Hua Ren Accepted 9 May 2014 Available online xxx Keywords: Polyethylene terephthalate Antimony Bisphenol A Release of antimony (Sb) and bisphenol A (BPA) from 16 brands of polyethylene terephthalate (PET) drinking water

  8. Transgenerational effects of obesogens and the obesity Raquel Chamorro-Garcia1

    E-Print Network [OSTI]

    Blumberg, Bruce

    , the components of various materials used to house the animals (plastic cages, plastic water bottles, bedding explanation for the increase in fat mass is an impaired balance between energy intake and energy expenditure recently demonstrated that animals living in close proxi- mity to human populations, such as pets, feral

  9. Novel method for hit-position reconstruction using voltage signals in plastic scintillators and its application to Positron Emission Tomography

    E-Print Network [OSTI]

    Raczynski, L; Kowalski, P; Wislicki, W; Bednarski, T; Bialas, P; Czerwinski, E; Kaplon, L; Kochanowski, A; Korcyl, G; Kowal, J; Kozik, T; Krzemien, W; Kubicz, E; Molenda, M; Moskal, I; Niedzwiecki, Sz; Palka, M; Pawlik-Niedzwiecka, M; Rudy, Z; Salabura, P; Sharma, N G; Silarski, M; Slomski, A; Smyrski, J; Strzelecki, A; Wieczorek, A; Zielinski, M; Zon, N

    2014-01-01

    Currently inorganic scintillator detectors are used in all commercial Time of Flight Positron Emission Tomograph (TOF-PET) devices. The J-PET collaboration investigates a possibility of construction of a PET scanner from plastic scintillators which would allow for single bed imaging of the whole human body. This paper describes a novel method of hit-position reconstruction based on sampled signals and an example of an application of the method for a single module with a 30 cm long plastic strip, read out on both ends by Hamamatsu R4998 photomultipliers. The sampling scheme to generate a vector with samples of a PET event waveform with respect to four user-defined amplitudes is introduced. The experimental setup provides irradiation of a chosen position in the plastic scintillator strip with an annihilation gamma quanta of energy 511~keV. The statistical test for a multivariate normal (MVN) distribution of measured vectors at a given position is developed, and it is shown that signals sampled at four threshold...

  10. Positron Emission Tomography Physics, Instrumentation, Data Analysis

    E-Print Network [OSTI]

    Liu, Thomas T.

    1 Positron Emission Tomography Physics, Instrumentation, Data Analysis Carl K. Hoh, MD Department PET Scanner Design · Smaller individual crystal size = better spatial resolution · Physical limit HR scanner = 24 elements in axial FOV.Axial FOV = 15 cm 2D and 3D Detector Configurations · 2D mode

  11. Novel method for hit-position reconstruction using voltage signals in plastic scintillators and its application to Positron Emission Tomography

    E-Print Network [OSTI]

    L. Raczynski; P. Moskal; P. Kowalski; W. Wislicki; T. Bednarski; P. Bialas; E. Czerwinski; L . Kaplon; A. Kochanowski; G. Korcyl; J. Kowal; T. Kozik; W. Krzemien; E. Kubicz; M. Molenda; I. Moskal; Sz. Niedzwiecki; M. Palka; M. Pawlik-Niedzwiecka; Z. Rudy; P. Salabura; N. G. Sharma; M. Silarski; A. Slomski; J. Smyrski; A. Strzelecki; A. Wieczorek; M. Zielinski; N. Zon

    2014-07-31

    Currently inorganic scintillator detectors are used in all commercial Time of Flight Positron Emission Tomograph (TOF-PET) devices. The J-PET collaboration investigates a possibility of construction of a PET scanner from plastic scintillators which would allow for single bed imaging of the whole human body. This paper describes a novel method of hit-position reconstruction based on sampled signals and an example of an application of the method for a single module with a 30 cm long plastic strip, read out on both ends by Hamamatsu R4998 photomultipliers. The sampling scheme to generate a vector with samples of a PET event waveform with respect to four user-defined amplitudes is introduced. The experimental setup provides irradiation of a chosen position in the plastic scintillator strip with an annihilation gamma quanta of energy 511~keV. The statistical test for a multivariate normal (MVN) distribution of measured vectors at a given position is developed, and it is shown that signals sampled at four thresholds in a voltage domain are approximately normally distributed variables. With the presented method of a vector analysis made out of waveform samples acquired with four thresholds, we obtain a spatial resolution of about 1 cm and a timing resolution of about 80 ps

  12. NMIS-07 SUBMITTED TO IEEE TRANSACTIONS ON NUCLEAR SCIENCE, MARCH 2002 SECOND REVIEW 1 Abstract--We consider detection of high-energy photons

    E-Print Network [OSTI]

    Zibulevsky, Michael

    Anger algorithm. Index Terms--emission tomography, gamma camera, scintillation detector, artificial on the Anger scintillation camera [1]. Incident high- energy gamma quanta, generated due to positron decay. Application of such thick crystals in PET scanners is desirable, due to their low cost and very high light

  13. U.S. Department of the Interior June 2001 U.S. Geological Survey

    E-Print Network [OSTI]

    for ball clay (30% and 25%, respectively); foundry sand (25%), pet waste absorbent (22%), drilling mud (19. Gonzales Utah * Redmond Clay and Salt Co. Inc. Sanpete * Western Clay Co. Sevier Wyoming * American Colloid Johnson, Natrona, Washakie * M-I Drilling Fluids Inc. Big Horn * Wyo-Ben Inc. Big Horn *Asterisk indicates

  14. IEEE TRANSACTIONS ON NUCLEAR SCIENCE, VOL. 52, NO. 3, JUNE 2005 599 Investigation of the "Block Effect" on Spatial

    E-Print Network [OSTI]

    Thompson, Chris

    IEEE TRANSACTIONS ON NUCLEAR SCIENCE, VOL. 52, NO. 3, JUNE 2005 599 Investigation of the "Block Effect" on Spatial Resolution in PET Detectors Nada Tomic, Student Member, IEEE, Christopher J. Thompson, Member, IEEE, and Michael E. Casey, Member, IEEE Abstract--Previous studies suggest that when block

  15. LEVEL SET REGULARIZATION IN POSITRON EMISSION TOMOGRAPHY 1 Level Set Method for Positron Emission

    E-Print Network [OSTI]

    Ferguson, Thomas S.

    LEVEL SET REGULARIZATION IN POSITRON EMISSION TOMOGRAPHY 1 Level Set Method for Positron Emission for integrated Petroleum Research). #12;LEVEL SET REGULARIZATION IN POSITRON EMISSION TOMOGRAPHY 2 Abstract In positron emission tomography (PET) a radioactive compound is injected into the body to promote a tissue

  16. A New Intermolecular Potential Model for the n-Alkane Homologous Series

    E-Print Network [OSTI]

    for the production of natural gas, pet- rochemicals, gasoline, kerosene, oil, and paraffin wax. They are utilized model for the n-alkane homologous series has been developed, param- eterized to the vapor-liquid used to determine the model parameters. The new model repro- duces the experimental saturated liquid

  17. High resolution scintillation detector with semiconductor readout

    DOE Patents [OSTI]

    Levin, Craig S. (Santa Monica, CA); Hoffman, Edward J. (Los Angeles, CA)

    2000-01-01

    A novel high resolution scintillation detector array for use in radiation imaging such as high resolution Positron Emission Tomography (PET) which comprises one or more parallelepiped crystals with at least one long surface of each crystal being in intimate contact with a semiconductor photodetector such that photons generated within each crystal by gamma radiation passing therethrough is detected by the photodetector paired therewith.

  18. Journal of Climate EARLY ONLINE RELEASE

    E-Print Network [OSTI]

    Camargo, Suzana J.

    , 2015: Terrestrial aridity and its response to greenhouse warming across CMIP5 climate models. J characterizing climatic aridity, it makes sense to consider P relative to potential37 evapotranspiration PET (e METEOROLOGICAL SOCIETY #12;Terrestrial aridity and its response to greenhouse warming1 across CMIP5 climate

  19. Terrestrial aridity and its response to greenhouse warming1 across CMIP5 climate models2

    E-Print Network [OSTI]

    Frierson, Dargan

    Terrestrial aridity and its response to greenhouse warming1 across CMIP5 climate models2 Jacob climatic aridity, it makes sense to consider P relative to potential37 evapotranspiration PET (e using v4.3.2 of the AMS LATEX template 1 #12;ABSTRACT 2 #12;The aridity of a terrestrial climate

  20. Endangering the endangered: The effects of perceived rarity on species exploitation

    E-Print Network [OSTI]

    Courchamp, Franck

    a model to explore the scenario of most conservation concern (where rarity itself fuels increased; Seidensticker et al. 1999; Davenport & Ndangalasi 2003; Gonzalez 2003; Haitao et al. 2007). To design ef, and there are thriving markets-- legal and illegal--in exotic pets (Slone et al. 1997), hunt- ing trophies (Baldus

  1. Characterisation of long term behaviour of polyester fibres and fibre assemblies for offshore mooring lines

    E-Print Network [OSTI]

    Burgoyne, Chris

    Characterisation of long term behaviour of polyester fibres and fibre assemblies for offshore: Polyethylene Terephthalate (PET), which is already used for offshore mooring, and Polyethylene Naphthalate (PEN for offshore mooring application, its higher stiffness resulting in lower offset and smaller mooring lines

  2. MSU Family & Graduate Housing Rental Rates Family & Graduate Housing is primarily intended to provide affordable housing for students with families, single graduates, upper

    E-Print Network [OSTI]

    Dyer, Bill

    .), dishes, cookware, etc. **Tenants are responsible for gas and electricity** Animals / pets are NOT ALLOWED, a self-cleaning oven with a timer, carpet, and have recently been remodeled. Wired/wireless Resnet-in for one reserved parking stall. Tenants are responsible for utilities** All units are unfurnished Wired/wireless

  3. FLUORIDE ION COMPLEXATION BY STIBONIUM LEWIS ACIDSTOWARD APPLICATION IN BIOIMAGING 

    E-Print Network [OSTI]

    Haile, Merid 1989-

    2011-05-06

    Fluoride has proven to be a helpful anion in improving dental health when added to drinking water and toothpaste but extremely detrimental to the body at higher concentrations. Its isotope 18F is useful as a labeling agent in PET imaging. Due...

  4. Power production experiments at the Test Beam Line in the CLIC Test Facility 3

    E-Print Network [OSTI]

    Lillestøl, Reidar Lunde; Adli, Erik; Lundheim, Lars Magne

    2010-01-01

    CLIC is an international study of a future multi-TeV electron-positron linear collider, where the energy of a high-intensity drive beam is extracted and transferred to the main beam via Power Extraction and Transfer Structures (PETS) in the form of rf power. The study of power production is therefore essential for the feasibility of CLIC. Power production in PETS has been studied, and ex- periments have been performed in the decelerator Test Beam Line in the CLIC Test Facility 3. In particular, the correlation of the power production and the beam position inside the structure has been studied. It is shown that the total produced power is constant when the beam has a position offset through the PETS. In addition, the difference between the measured phases from each side is independent of the beam position, which allows for efficient combination of the fields. However, the ratio of the power on each side of the PETS unexpectedly shows a linear dependence on the horizontal offset, with a correlation value of 0.8...

  5. EuroGeo4 Paper number 203 ANALYSIS OF MECHANICAL AND PHYSICAL PROPERTIES ON GEOTEXTILES AFTER

    E-Print Network [OSTI]

    Zornberg, Jorge G.

    EuroGeo4 Paper number 203 1 ANALYSIS OF MECHANICAL AND PHYSICAL PROPERTIES ON GEOTEXTILES AFTER-mail: nataliacorreia@uol.com.br) Abstract: When geotextiles are exposed to solar rays for a short or long period and physical properties on 3 polyester PET non-woven geotextiles that were exposed to weathering for 720

  6. Avaliao da Fluncia de Geotxteis no Tecidos com Ensaios Acelerados

    E-Print Network [OSTI]

    Zornberg, Jorge G.

    -Wowen Geotextile Using Accelerated Tests Avaliación de la Fluencia de Geotextiles no Tecidos con Ensayos Acelerados out on two non-woven geotextiles (PP and PET) using temperature accelerated creep test, namely, Stepped Isothermal Method (SIM), non woven geotextiles. Resumen. La obtención de resultados de fluencia en

  7. Ecological Applications, 21(3), 2011, pp. 619639 2011 by the Ecological Society of America

    E-Print Network [OSTI]

    Thomas, David D.

    be an effective and efficient way to reduce pollution. For example, 20% of households contributed 75% of air activities including air and motor vehicle travel, food consumption, home energy use, landscape, pets total input fluxes of elements. For instance, air and motor vehicle transportation, together with home

  8. MASSIVE WEIGHT SHARING: A CURE FOR EXTREMELY ILL-POSED PROBLEMS

    E-Print Network [OSTI]

    Lautrup, Benny

    . STROTHER PET Imaging Service, VA Medical Center Minneapolis, Minnesota, USA In most learning problems parameters in the learning machine. Extremelyill-posedlearningproblemsare, however, commonin image or large amounts of computer time. The method is based upon the observationthat the standard learning rules

  9. Seedless synthesis of patterned ZnO nanowire arrays on metal thin films (Au, Ag, Cu, Sn) and their application for flexible electromechanical sensing

    E-Print Network [OSTI]

    Wang, Zhong L.

    ) and their application for flexible electromechanical sensing Xiaonan Wen, Wenzhuo Wu, Yong Ding and Zhong Lin Wang on flexible substrates as an electromechanical switch in response to externally applied strain exhibits-fabricated ZnO NW arrays on underlying flexible polyethylene terephthalate (PET) substrates as electromechanical

  10. Open Archive TOULOUSE Archive Ouverte (OATAO) OATAO is an open access repository that collects the work of Toulouse researchers and

    E-Print Network [OSTI]

    Mailhes, Corinne

    -impregnated of the polyester thermoplastic adhesive have been investigated by differ- ential scanning calorimetry (DSC) and dynamic dielectric spectroscopy (DDS). The thermoplastic polyester adhesive and the oriented PET films with high shear strength is required. This polyester thermoplastic adhesive is also called the hot melt

  11. Microwave Absorption of Single-Walled Carbon Nanotubes/Soluble Cross-Linked Polyurethane Composites

    E-Print Network [OSTI]

    Gao, Hongjun

    (EMI) shielding and radar cross section (RCS) reduction applications with both commercial and defense absorbing and shielding materials in the high-frequency range due to their many unique chemical and physical demonstrated that MWNTs show strong microwave absorption with a matrix of polyethylene tereph- thalate (PET)13

  12. Bibliography of Soft X-ray Microscopy (UPDATE of supplemental material for Polymer invited review) A.P. Hitchcock

    E-Print Network [OSTI]

    Hitchcock, Adam P.

    (-caprolacatam) PAR polyacrylate PBMA poly-n-butyl-methacrylate PPrS poly-bromo-styrene PC polycarbonate PET poly + ethylenediamine + MDI) RBC poly[(styrene-r-isoprene)-b-(styrene-r-isoprene)], (S/I)-b-(S/I), copolymer; = 75/25; = 50/50 (wt %) S/I block compositions SEBS poly(styrene-b-ethylene butylene-b-styrene) TDI toluene di

  13. PEREA: Practical TTP-Free Revocation of Repeatedly Misbehaving Anonymous Users

    E-Print Network [OSTI]

    Kapadia, Apu

    regimes, and activism. Fully anonymous access to services, however, can give users the license to misbe of such systems as an im- portant part of their roadmap,2 and in 2009 the PET award committee recognized our for the Award for Outsta

  14. PEREA: Practical TTP-Free Revocation of Repeatedly Misbehaving Anonymous Users

    E-Print Network [OSTI]

    Kapadia, Apu

    in oppressive regimes, and activism. Fully anonymous access to services, however, can give users the license of their roadmap,2 and in 2009 the PET award committee recognized our recent work for improving such systems.3 [35] and PEREA [36] were recognized as Runners up for the Award for Outstanding Research in Privacy

  15. 99APRIL 2011 Published by the IEEE Computer Society0018-9162/11/$26.00 2011 IEEE

    E-Print Network [OSTI]

    Li, Jing

    - mately, death. The disease currently affects about 5.3 million people in the US, and the number was the seventh-leading cause of death across all ages in the US in 2006; it was the fifth-leading cause of death, for Tesla, is a unit of magnetic flux density); half undergo fluorodeoxyglucose (FDG) PET scans. FDG

  16. Phytologia (April 2010) 92(1) 59 GEOGRAPHIC VARIATION AND SYSTEMATICS OF

    E-Print Network [OSTI]

    Adams, Robert P.

    . FROM MADEIRA AND THE CANARY ISLANDS: SNPS FROM nrDNA and petN-psbM Robert P. Adams Biology Department Island Ecology and Evolution Research Group (IPNA-CSIC), 38206 La Laguna, Tenerife, Canary Islands, Spain phoenicea from Madeira, Canary Islands, Morocco, and El Penon, Spain along with J. p. var. turbinata from

  17. Cook food to proper temperature.

    E-Print Network [OSTI]

    Liskiewicz, Maciej

    and after handling or eating food; nafter playing with pets or visiting a zoo; nafter coughing, sneezing out of their mouths when they cough or sneeze. · Have the children touch something (table or chair. · Explain that if you wash your hands after coughing or sneezing in them, the germs will be washed away

  18. Determination of the effects caused by different polymers on coal fluidity during carbonization using high-temperature {sup 1}H NMR and rheometry

    SciTech Connect (OSTI)

    Miguel Castro Diaz; Lucky Edecki; Karen M. Steel; John W. Patrick; Colin E. Snape [Nottingham University, Nottingham (United Kingdom). Nottingham Fuel and Energy Centre, School of Chemical, Environmental and Mining Engineering

    2008-01-15

    The effects of blending polyethylene (PE), polystyrene (PS), poly(ethyleneterephthalate) (PET), a flexible polyurethane (FPU), and a car shredded fluff waste (CSF) on fluidity development of a bituminous coal during carbonization have been studied by means of high-torque, small-amplitude controlled-strain rheometry and in situ high-temperature {sup 1}H NMR spectroscopy. The most detrimental effects were caused by PET and PS, which completely destroyed the fluidity of the coal. The CSF had a deleterious effect on coal fluidity similar to that of PET, although the deleterious effect on the viscoelastic properties of the coal were less pronounced than those of PET and PS. On the contrary, the addition of 10 wt % PE caused a slight reduction in the concentration of fluid hydrogen and an increase in the minimum complex viscosity, and the addition of 10 wt % FPU reduced the concentration of fluid hydrogen without changing the viscoelastic properties of the coal. Although these results suggest that these two plastics could potentially be used as additives in coking blends without compromising coke porosity, it was found that the semicoke strengths were reduced by adding 2 wt % FPU and 5 wt % PE. Therefore, it is unlikely that more than 2 wt % of a plastic waste could be added to a coal blend without deterioration in coke quality. 35 refs., 11 figs., 3 tabs.

  19. Abstract--Brain activity generates electrical potentials that are spatio-temporal in nature. EEG is the least costly and

    E-Print Network [OSTI]

    Besio, Walter G.

    Abstract--Brain activity generates electrical potentials that are spatio-temporal in nature. EEG and selectivity of the surface electrical activity as it takes the second spatial derivative of the potential electrical activity by functional magnetic resonance imaging (fMRI) and positron emission tomography (PET

  20. Alignment versus diagnosticity: A critical test of two theories of conceptual

    E-Print Network [OSTI]

    Costello, Fintan

    or to understand a novel compound such as "cactus fish", "street gun" or "pet lobster", we witness of the concepts in the compound is asserted as true of the other; as in "an elephant fish is a big fish", where the property BIG is transferred from the elephant to fish. Typically, properties are transferred from

  1. Fractional-Order Signal Processing using a Polymer-Electrolyte Transistor Robert L. Ewing1

    E-Print Network [OSTI]

    Stevens, Ken

    in silicon processing. This paper focuses on examining the fractional dynamic response of the LSL polymer-electrolyteFractional-Order Signal Processing using a Polymer-Electrolyte Transistor Robert L. Ewing1 , Hoda S-order functions. This paper addresses the use of a polymer-electrolyte transistor (PET) for use in implementating

  2. Salmonella Isolates from Wild-Caught Tokay Geckos (Gekko gecko) Imported to the U.S. from Indonesia

    E-Print Network [OSTI]

    Smith, Kate

    Salmonella Isolates from Wild-Caught Tokay Geckos (Gekko gecko) Imported to the U.S. from Indonesia States (U.S.), the majority of which are sold in the pet trade. Characterizing Salmonella shedding results of a pilot survey of Salmonella serotypes isolated from wild-caught Indonesian Tokay geckos (Gekko

  3. Medical Multimedia and Multimodality Databases Systems Peter L. Stanchev

    E-Print Network [OSTI]

    Stanchev, Peter

    and software have resulted in a shift from paper-based medical record to electronic medical record systems tomography (PET), ultrasound, electrical source (ESI), electrical impedance tomography (EIT). Medical systems, interpretation, management and communication of multimodality images, expandable and open system architecture

  4. Bunny Cafe

    E-Print Network [OSTI]

    Hacker, Randi

    2010-06-16

    types of pet cafes: one where you can eat with cats and one where you can eat with bunnies. At Neko Jalala customers drop in after a stressful day at work and pay anywhere from eight to twelve bucks an hour to sip tea and pat a cat, or neko, in Japanese...

  5. Knock-Out of the Genes Coding for the Rieske Protein and the ATP-Synthase -Subunit of Arabidopsis.

    E-Print Network [OSTI]

    , Research Triangle Park, North Carolina 27709 (J.Z.L.) In Arabidopsis, the nuclear genes PetC and AtpD code are evident when mRNA expression profiles of nucleus-encoded chloroplast proteins are considered, suggesting response. Plants use light energy to drive electron and proton transport across the thylakoid membrane

  6. Copyright: King Fahd University of Petroleum & Minerals; http://www.kfupm.edu.sa

    E-Print Network [OSTI]

    El-Alfy, El-Sayed

    © Copyright: King Fahd University of Petroleum & Minerals; http://www.kfupm.edu.sa A Heuristic. of Pet. & Miner., Dhahran; Advanced Communication Technology, The 9th International conference of Petroleum & Minerals http://www.kfupm.edu.sa Summary A primary goal of this paper is to develop a heuristic

  7. Copyright: King Fahd University of Petroleum & Minerals; http://www.kfupm.edu.sa

    E-Print Network [OSTI]

    El-Alfy, El-Sayed

    © Copyright: King Fahd University of Petroleum & Minerals; http://www.kfupm.edu.sa A Learning-Dong Yao Heffes, H.;Dept. of Comput. Sci., King Fahd Univ. of Pet. & Miner., Dhahran; Wireless & Minerals http://www.kfupm.edu.sa Summary An efficient channel allocation policy that prioritizes handoffs

  8. Material Safety Data Sheet according to ANSI Z400.1-2004 and 29 CFR 1910.1200

    E-Print Network [OSTI]

    Wikswo, John

    Material Safety Data Sheet according to ANSI Z400.1- 2004 and 29 CFR 1910.1200 WINDEX® ORIGINAL;Material Safety Data Sheet according to ANSI Z400.1- 2004 and 29 CFR 1910.1200 WINDEX® ORIGINAL GLASS AND PETS. #12;Material Safety Data Sheet according to ANSI Z400.1- 2004 and 29 CFR 1910.1200 WINDEX

  9. Laser Induced Nuclear Physics and Applications K.W.D. Ledingham,

    E-Print Network [OSTI]

    Strathclyde, University of

    receiving an injection of a pharmaceutical labeled with a short-lived + emitting source which collects used radio- pharmaceutical is 2-fluoro-2-deoxyglucose 2-[18 F]FDG. Over the last few years the value of PET FDG in the management of cancer patients has been widely demonstrated. Figure 1 highlights

  10. DFG Research Center mathematics for

    E-Print Network [OSTI]

    Tabelow, Karsten

    DFG Research Center MATHEON mathematics for key technologies www.matheon.de Project A3 since 06/2002 Image and signal processing in medicine and biosciences Jörg Polzehl Vladimir Spokoiny Karsten Tabelow adaptive smoothing proce- dure that identify and use anisotropy information in the data. PET The observed

  11. Design and Development of a Miniaturized Embedded UHF RFID Tag for Automotive Tire Applications

    E-Print Network [OSTI]

    Tentzeris, Manos

    . Basat (1) , M.M. Tentzeris (1) , J. Laskar (1) (1) School of ECE, Georgia Institute of Technology 85 or pet tracking. In these applications data are contact-free transferred to a local querying system based IC packaging process and the miniaturized antenna is built in the lead frame. Passive ICs

  12. Simulation of Algorithms for Pulse Timing in Michael D. Haselman, Member IEEE, Scott Hauck, Senior Member IEEE, Thomas K. Lewellen,

    E-Print Network [OSTI]

    Hauck, Scott

    processing algorithms with clock rates well above 100MHz. This, combined with FPGA's low expense and ease of use, make them an ideal technology for pulse timing and are a central part of our next generation of electronics for our pre-clinical PET scanner systems. To that end, our laboratory has been developing a pulse

  13. TECHNOLOGY ASSESSMENT AND GLOBALIZATION bridges vol. 16, December 2007 / Pielke's Perspective

    E-Print Network [OSTI]

    Colorado at Boulder, University of

    of the worthless fish, or if they were lucky, sell it for about five cents per pound to be processed into pet food1 of 3 TECHNOLOGY ASSESSMENT AND GLOBALIZATION bridges vol. 16, December 2007 / Pielke of technology in globalization and the role of technology assessment in our efforts to manage the effects

  14. FPGA-Based Pulse Pile-up Correction M.D. Haselman1

    E-Print Network [OSTI]

    Hauck, Scott

    processing suite for a small animal PET scanner. The addition of a pulse pile Field Programmable Gate Arrays (FPGAs) are capable of performing complex discrete signal processing, and selected dedicated hardware make them an ideal technology for a data acquisition system for a positron

  15. Greyson Parrelli, Prof. Mooi Choo Chuah CSE, Lehigh University, Bethlehem, PA 18015

    E-Print Network [OSTI]

    Spletzer, John R.

    look promising. These interactive mobile technologies appear to be a fantastic way for individuals... with your pet fish. Taking care of it requires gold coins, which can be earned by answering questions EDIT can use the following process to find such candidates. Then, for every count, we can define frequency

  16. Journal of Intelligent Information Systems, 17:2/3, 301322, 2001 c 2001 Kluwer Academic Publishers. Manufactured in The Netherlands.

    E-Print Network [OSTI]

    Risch, Tore

    in the form of PET and fMRI scans. A dynamic set of processing modules transform the raw image data, Royal Institute of Technology, Stockholm, Sweden; Division of Human Brain Research, Department Analysis and Computer Science, Royal Institute of Technology, Stockholm, Sweden; Department of Data

  17. MR imaging in the non-human primate: studies of function and of dynamic connectivity

    E-Print Network [OSTI]

    of Physiology of Cognitive Processes, Spemannstr 38, 72076 Tu¨ bingen, Germany e-mail: nikos.logothetis@tuebingen.mpg.de Current Opinion in Neurobiology 2003, 13:1­13 This review comes from a themed issue on New technologies extracellular field potential MRI magnetic resonance imaging MUA multiple-unit spiking activity PET positron

  18. 344 | VOL.3 NO.5 | MAY 2006 | NATURE METHODS NEWS AND VIEWS

    E-Print Network [OSTI]

    Cai, Long

    : deconvolution clears the haze Ben W Strowbridge A deceptively simple signal processing method allows researchers- gies,such as functional magnetic resonance imaging (fMRI) and positron emission tomography (PET-mail: bens@case.edu tested per patient.This study required all the technology described above, and the cyto

  19. Independent component analysis of functional MRI: what is signal and what is noise?

    E-Print Network [OSTI]

    Opinion in Neurobiology 2003, 13:620­629 This review comes from a themed issue on New technologies Edited that induce localized motion of brain tissue [2]. In contrast to positron emission tomography (PET), in which be analyzed by different signal processing strategies that emphasize either the spatial or the temporal

  20. TRICTRAC Video Dataset: Public HDTV Synthetic Soccer Video Sequences With Ground Truth.

    E-Print Network [OSTI]

    Piater, Justus H.

    monitoring, marketing and sport analysis. In order to enhance these technologies, an objective performance with the ground truth. One of the contributions of the TRICTRAC project is the supply to the video processing and Surveillance (PETS) workshop deals with these issues since 2000. It proposes datasets for surveillance, sports

  1. Privacy Design Strategies (extended abstract) Jaap-Henk Hoepman1

    E-Print Network [OSTI]

    Hoepman, Jaap-Henk

    implementation, but low when starting the project. Nu- merous privacy enhancing technologies (PETs) exists classification of privacy design patterns and the underlying pri- vacy enhancing technologies. We therefore development process. In other words starting when the initial concepts and ideas for a new system are drafted

  2. nature methods | VOL.10 NO.5 | MAY 2013 | 375 correspondence

    E-Print Network [OSTI]

    Cai, Long

    three-dimensional entity folded through a tightly regulated process1,2 with important functions the chromosomes into distinct compartments3­6. Recent technological innovations, including chromosome conformation capture carbon copy (5C), Hi-C and chromatin interaction analysis by paired-end tag sequencing (ChIA-PET

  3. FPGA-Based Pulse Pileup Correction M.D. Haselman1

    E-Print Network [OSTI]

    Hauck, Scott

    of this and previous work is to develop an all-digital FPGA-based signal processing suite for a small animal PET Field Programmable Gate Arrays (FPGAs) are capable of performing complex discrete signal processing dedicated hardware make them an ideal technology for a data acquisition system for a positron emission

  4. Perspective Toward a Neural Basis for Social Behavior

    E-Print Network [OSTI]

    Adolphs, Ralph

    1,* 1Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA, neurotrans- mitters, circuits and systems, as well as collective behavior in groups) and stages of processing using PET (Fletcher et al., 1995; Happe´ et al., 1996; Morris et al., 1996), but the tools available

  5. Published in Medical Image Analysis, 1(2):91108, 1996. Deformable Models

    E-Print Network [OSTI]

    Terzopoulos, Demetri

    Tracking. 1 Introduction The rapid development and proliferation of medical imaging technologies, with the assistance of computers, clinically useful information about anatomic structures imaged through CT, MR, PET these elements into a coherent and consistent model of the structure. Traditional low-level image processing

  6. 3D objects visualization for remote interactive medical applications Johan Montagnat, Eduardo Davila, Isabelle E. Magnin

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    processing of these data often allow quantita- tive and repeatable measurements on large databases that are valuable for diagnosis and pathology studies. Grid technologies offer large and distributed computing power (PET), Single Photon Emission Com- puted Tomography (SPECT), and recently 3D ultrasound devices (US

  7. MCAT to XCAT: The Evolution of 4-D Computerized Phantoms

    E-Print Network [OSTI]

    of medical imaging devices and technology. By W. Paul Segars and Benjamin M. W. Tsui, Member IEEE ABSTRACT in realism, the phantoms developed in our lab can be combined with accurate models of the imaging process (SPECT, PET, CT, magnetic resonance imaging, and ultrasound) to generate simulated imaging data close

  8. Behavioral/Systems/Cognitive Gain Mechanisms for Contextually Guided

    E-Print Network [OSTI]

    Andersen, Richard

    Institute of Technology, Pasadena, California 91125, and 2Bernstein Center for Computational Neuroscience it or rolling it, all de- pending on the rules of a game. Sensorimotor processing streams (Kalaska, 1996; Wise identical sensory conditions (Pet- rides, 1982; Platt and Glimcher, 1999; Wallis and Miller, 2003; Pasupathy

  9. Complex Distillation Arrangements : Extending the Petlyuk Ideas

    E-Print Network [OSTI]

    Skogestad, Sigurd

    and Technology N--7034 Trondheim Norway Abstract The task of separating a multicomponent mixture into streams shell using dividing walls or vertical partitions. INTRODUCTION Industrial distillation processes is also known as the Petlyuk column, due to a theoretical study of Pet­ lyuk et al. (1965), or as a fully

  10. Functional Paleontology: System Evolution as the User Sees It

    E-Print Network [OSTI]

    Reeves, Douglas S.

    of Engineering College of Computing North Carolina State University Georgia Institute of Technology 1010 Main. Examples include Òcall forwardingÓ in telephone switching and Òspell checkingÓ in word processing investigated the evolution of structure and function in physical artifacts as diverse as the paperclip [Pet92

  11. MINORS 7/23/2012 College Minor Code Description

    E-Print Network [OSTI]

    Pittendrigh, Barry

    &Envrmtl Sci Agriculture PLBI Plant Biology Agriculture PLTP Plant Pathology Agriculture PTFD Pet Food Processing Agriculture SOIL Soil Science Agriculture SUEV Sustainable Environments Agriculture UFOR Urban Physics Science STAT Statistics Technology BCMT Building Const Mgmt Tech #12;MINORS 7/23/2012 College

  12. To Mindstorms and Beyond: Evolution of a Construction Kit for Magical Machines

    E-Print Network [OSTI]

    on technology, the intent is to reveal the process by which we were led along in creating these systems a special relationship to the world of technology we are living in. The magic of technology, so much a part by the wonder of a machine acting like a pet. Designing tools that allow children to add computation

  13. Pre-nets, read arcs and unfolding: a functorial presentation

    E-Print Network [OSTI]

    Baldan, Paolo

    of the most widely known models of concurrency. Since their introduction, almost fifty years ago [Pet62 in the ITPh. Roughly these can be classified in process-oriented, unfolding, algebraic, and logical: Research and Technologies, and by the CS Department of the University of Illinois at Urbana-Champaign. #12;2 P. Baldan, R

  14. A Clinical Application of Ensemble ICA to the Quantification of Myocardial Blood Flow in Dynamic

    E-Print Network [OSTI]

    Choi, Seungjin

    15 2 O PET Byeong Il Lee , Jae Sung Lee , Dong Soo Lee , Won Jun Kang , Jong Jin Lee , Seungjin Choi Science Pohang University of Science and Technology San 31 Hyoja-dong, Nam-gu Pohang 790-784, Korea Tel Signal Processing Systems #12;1 Abstract Ensemble independent component analysis (ICA) is a Bayesian

  15. CLASSIFICATION OF SINGLE TRIAL EEG SIGNALS BY A COMBINED PRINCIPAL + INDEPENDENT COMPONENT ANALYSIS AND PROBABILISTIC NEURAL NETWORK

    E-Print Network [OSTI]

    Vialatte, François

    Processing, BSI RIKEN, 2-1, Hirosawa, Wakoh-City, Saitama 351-0198, Japan Department of Mathematical 113-8654, Japan¡ Department of Electronic Engineering, Saitama Institute of Technology, 1690 Fusaiji-invasive instrumentations such as EEG, MEG, fMRI, or PET devices. This direction is quite significant for the development

  16. Medical Imaging: ECE-4BF3 Michael D. Noseworthy, Ph.D., P.Eng.

    E-Print Network [OSTI]

    Haykin, Simon

    acquisition and formation; post-processing for magnetic resonance imaging and spectroscopy; comparisons Objectives This course is designed to allow students to become familiar with medical imaging technologies applications with other imaging modalities (e.g. PET, SPECT, ultrasound, mammography, CT, EEG, MEG

  17. Medical Imaging: ECE-4BF3 Winter 2012

    E-Print Network [OSTI]

    Haykin, Simon

    and formation; post-processing for magnetic resonance imaging and spectroscopy; comparisons to other medical with medical imaging technologies- both from a physics and engineering perspective through to a practical.). However, comparative applications with other imaging modalities (e.g. PET, SPECT, ultrasound, mammography

  18. Protrusion of forearc mantle serpentinites along major strike-slip faults in an oceanic subduction complex in Dominican Republic

    E-Print Network [OSTI]

    , Le Fonds Quebécois de la Recherche sur la Nature et les Technologies, the University of Ottawa-type peridotites and spatially associated lavas, Contrib. Min. Pet. 86(1984) 54-76. [9] W.F. McDonough, S.S. Sun, melt extraction and post-melting processes beneath mid-ocean ridges, Journal of Petrology 45(2004) 2423

  19. What Neural Correlates Underlie Successful Encoding and Retrieval? A Functional Magnetic Resonance Imaging Study

    E-Print Network [OSTI]

    Corkin, Suzanne

    Corkin1,2 1Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge al., 1996; Naveh-Benjamin et al., 2000a,b). Positron emission to- mography (PET) studies using versus the hard task because some encoding-related processes were not performed with concurrent

  20. EINDHOVEN UNIVERSITY OF TECHNOLOGY Department of Mathematics and Computer Science

    E-Print Network [OSTI]

    Eindhoven, Technische Universiteit

    is a widely used technique e.g. for the production of PET bottles. In a stretch blow moulding process a hotEINDHOVEN UNIVERSITY OF TECHNOLOGY Department of Mathematics and Computer Science CASA-Report 11 Department of Mathematics and Computer Science Eindhoven University of Technology P.O. Box 513 5600 MB