National Library of Energy BETA

Sample records for american lung association

  1. Comments of the Southern Environmental Law Center and the American Lung

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Association in response to the Department of Energy's Emergency Order to Resume Operations at the Potomac River Generating Station in Alexandria, VA | Department of Energy the Southern Environmental Law Center and the American Lung Association in response to the Department of Energy's Emergency Order to Resume Operations at the Potomac River Generating Station in Alexandria, VA Comments of the Southern Environmental Law Center and the American Lung Association in response to the Department

  2. Moore honored with American Statistical Association award

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    American Statistical Association Award Moore honored with American Statistical Association award Lisa Moore is the recipient of the 2013 Don Owen Award presented by the American Statistical Association, San Antonio Chapter. May 24, 2013 Leslie "Lisa" Moore Leslie "Lisa" Moore The American Statistical Association (ASA) is the world's largest community of statisticians. It was founded in Massachusetts in 1839. Leslie "Lisa" Moore of the Laboratory's Statistical

  3. American Gas Association | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Association American Gas Association Memorandum Summarizing Ex Parte Communication 111011_Ex_Parte.pdf (691.79 KB) More Documents & Publications Ex Parte Memorandum - Natural Resources Defense Council American Gas Association Ex Parte Communication Microsoft Word - AGA Comments on 2011 Regulatory Burden RFI

  4. American Evaluation Association Guiding Principles for Evaluators...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Five principles developed by American Evaluation Associ intended to guide professional practice of evaluators & to inform evaluation clients and the general public about principles ...

  5. American Evaluation Association Guiding Principles for Evaluators

    SciTech Connect (OSTI)

    None

    2009-01-18

    Five principles developed by American Evaluation Associ intended to guide professional practice of evaluators & to inform evaluation clients and the general public about principles they can expect to be upheld by professional evaluators.

  6. Los Alamos' Terwilliger named American Crystallographic Association

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    president Terwilliger named American Crystallographic Association president Los Alamos' Terwilliger named American Crystallographic Association president The ACA is the home to more than 1,000 scientists around the country who use X-rays, neutrons and electrons to see the shapes of molecules. April 27, 2016 Tom Terwilliger Tom Terwilliger Contact Nick Njegomir Communications Office (505) 665-9394 Email "This is an exciting time for crystallography because there are new ways to look at

  7. Workplace Charging Challenge Partner: American Lung Association...

    Energy Savers [EERE]

    The ALAC was the first organization to install a charging station through the Charge Ahead Colorado grant program in 2013. The ALAC offers two charging stations to employees and ...

  8. American Wind Energy Association (AWEA) | Open Energy Information

    Open Energy Info (EERE)

    AWEA) Jump to: navigation, search Logo: American Wind Energy Association (AWEA) Name: American Wind Energy Association (AWEA) Address: 1501 M Street, NW, Suite 1000 Place:...

  9. Los Alamos' Terwilliger named American Crystallographic Association

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Terwilliger named American Crystallographic Association president April 27, 2016 LOS ALAMOS, N.M., April 27, 2016-Tom Terwilliger, the developer of software enabling clear X-ray imaging of protein molecules, is the 2016 President of the American Crystallographic Association. The ACA is the home to more than 1,000 scientists around the country who use X-rays, neutrons and electrons to see the shapes of molecules."This is an exciting time for crystallography because there are new ways to look

  10. Comments of The American Public Power Association | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    The American Public Power Association Comments of The American Public Power Association The American Public Power Association responds to the U.S Department of Energy's Request for Information on addressing policy and logistical challenges to the implementation of smart grid technologies. Comments of The American Public Power Association (826.11 KB) More Documents & Publications Comments of the American Public Power Association Re: Comments on NBP RFI: Data Access Comments of the National

  11. Kelly named Fellow of the American Statistical Association

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Kelly named ASA Fellow Kelly named Fellow of the American Statistical Association The American Statistical Association (ASA) has honored Elizabeth Kelly with the title of Fellow. August 2, 2016 Elizabeth Kelly Elizabeth Kelly Communications Office (505) 667-7000 Kelly is a member of the American Statistical Society and the American Society for Quality. The American Statistical Association (ASA) has honored Elizabeth Kelly of the Lab's Statistical Sciences group with the title of Fellow. The ASA

  12. American Bar Association Section on Environment | Open Energy...

    Open Energy Info (EERE)

    Bar Association Section on Environment Jump to: navigation, search Name: American Bar Association Section on Environment Place: Chicago, Illinois Zip: 60610 Product: The Section of...

  13. American Wind Energy Association AWEA | Open Energy Information

    Open Energy Info (EERE)

    Energy Association AWEA Jump to: navigation, search Name: American Wind Energy Association (AWEA) Place: Washington DC, Washington, DC Zip: 20001 Sector: Wind energy Product:...

  14. American Evaluation Association Guiding Principles for Evaluators, 2004 |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy American Evaluation Association Guiding Principles for Evaluators, 2004 American Evaluation Association Guiding Principles for Evaluators, 2004 Five principles developed by American Evaluation Associ intended to guide professional practice of evaluators & to inform evaluation clients and the general public about principles they can expect to be upheld by professional evaluators. Guiding Principles for Evaluators (204.88 KB) More Documents & Publications ORSSAB

  15. SRS employees raise funds for American Heart Association | National Nuclear

    National Nuclear Security Administration (NNSA)

    Security Administration | (NNSA) raise funds for American Heart Association Tuesday, April 1, 2014 - 10:00am About 300 employees of Savannah River Site management and operation contractor Savannah River Nuclear Solutions participated in the annual Central Savannah River Area Heart Walk, raising funds for the American Heart Association. SRNS employees raised $76,492, and SRNS donated $10,000. SRS employees raise funds for American Heart Association Related Topics community donations srs

  16. Sandia highlighted at the 2016 American Wind Energy Association...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    highlighted at the 2016 American Wind Energy Association (AWEA) Conference, May 23-26th - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy ...

  17. Remarks by Secretary Moniz to the American Association for the...

    Energy Savers [EERE]

    for the Advancement of Science -- As prepared for delivery Remarks by Secretary Moniz to the American Association for the Advancement of Science -- As prepared for delivery ...

  18. American Wind Energy Association Wind Energy Finance and Investment Seminar

    Broader source: Energy.gov [DOE]

    The American Wind Energy Association Wind Energy Finance and Investment Seminar will be attended by representatives in the financial sector, businesses, bankers, government and other nonprofit...

  19. Comments of the American Public Power Association | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    party use, and privacy as related to the implementation of smart grid technology. Comments of the American Public Power Association (211.62 KB) More Documents & Publications Re: ...

  20. Two Sandia Leaders Elected American Association for the Advancement...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sandia Leaders Elected American Association for the Advancement of Science Fellows - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & ...

  1. American Gas Association (AGA) for DOE Furnace Product Class | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy (AGA) for DOE Furnace Product Class American Gas Association (AGA) for DOE Furnace Product Class Thank you for the opportunity to brief your staff in recent weeks on an impact analysis of a national condensing furnace standard, which was conducted jointly by the American Gas Association (AGA), the American Public Gas Association (APGA), and the Gas Technology Institute (GTI). AGA e-mail for DOE Furnace Product Class (83.56 KB) AGA Cover Letter for Furnace Product Class White Paper

  2. QER- Comment of American Wind Energy Association 1

    Office of Energy Efficiency and Renewable Energy (EERE)

    Attached please find the comments of the American Wind Energy Association (AWEA) on the QER. Please don’t hesitate to contact me if you have any questions. Thank you. Tom

  3. Energy Department and American Public Power Association Sign Agreement to

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Accelerate Growth of Electric Vehicle Market | Department of Energy and American Public Power Association Sign Agreement to Accelerate Growth of Electric Vehicle Market Energy Department and American Public Power Association Sign Agreement to Accelerate Growth of Electric Vehicle Market July 22, 2016 - 1:47pm Addthis News Media Contact 202-586-8604 DOENews@hq.doe.gov WASHINGTON - Today, Acting Assistant Secretary for the Office of Energy Efficiency and Renewable Energy David Friedman signed

  4. American Gas Association Memorandum Summarizing Ex Parte Communication |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Memorandum Summarizing Ex Parte Communication American Gas Association Memorandum Summarizing Ex Parte Communication On October 9, 2014, a workshop was hosted by the American Gas Association and Washington Gas Light (WGL) at WGLs Training Facility in Springfield, VA. AGA Memorandum Summarizing Ex Parte Communication (90.19 KB) Condensing Heating and Water Heating Equipment Workshop Agenda (69.08 KB) October 9th Workshop Presentation - Melissa Adams (1.12 MB) October 9th

  5. OSTIblog Articles in the American Association for the Advancement of

    Office of Scientific and Technical Information (OSTI)

    Science Topic | OSTI, US Dept of Energy Office of Scientific and Technical Information American Association for the Advancement of Science Topic Join OSTI at the AAAS Annual Meeting, February 17-21 by Dr. Walt Warnick 01 Feb, 2011 in Science Communications 3076 OSTIhpArchitecture.jpg Join OSTI at the AAAS Annual Meeting, February 17-21 Read more about 3076 The Department of Energy's Office of Scientific and Technical Information (OSTI) will be at the American Association for the Advancement

  6. Workplace Charging Challenge Partner: American Lung Association in Colorado

    Broader source: Energy.gov [DOE]

    Joined the Challenge: September 2015Headquarters: Greenwood Village, COCharging Location: Greenwood Village, CODomestic Employees: 14

  7. The respiratory health and lung function of Anglo-American children in a smelter town

    SciTech Connect (OSTI)

    Dodge, R.

    1983-02-01

    Cooper smelters are large, usually isolated, sources of air pollution. Arizona has several such plants on the periphery of small communities. The smelters emit predominantly sulfur oxides and particulates, and the residents of these communities intermittently are exposed to high concentrations (24-h sulfur dioxide (SO2) . 250 to 500 micrograms/m3) of smelter smoke but little other pollution. This study compared the respiratory health of Anglo-American school children who lived in one smelter community with children living in another small community in Arizona that was free of smelter air pollution. The prevalence of cough, as determined by questionnaire, was 25.6% in the smelter town children and 14.3% in the nonsmelter town children (p less than 0.05). Pulmonary function at the study onset was equal in the two groups. Over the course of the 4 yr of study, lung function growth (measured as actual forced expiratory volume in one second (FEV1) after 4 yr of study minus predicted FEV1) was also equal in the smelter town and nonsmelter town children. These results suggest that children in smelter communities have slightly more cough when compared with children living in other communities, but no differences in initial lung function or lung function at yearly testing over the period of the study.

  8. QER- Comment of American Public Power Association 6

    Broader source: Energy.gov [DOE]

    To whom it may concern: Please find attached comments jointly filed by the American Public Power Association, Large Public Power Council, and Transmission Access Policy Study Group, in relation to the issues discussed at the October 6, 2014, QER Public Stakeholder Meeting on Finance (Transmission, Storage and Distribution).

  9. Sandia highlighted at the 2016 American Wind Energy Association (AWEA)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Conference, May 23-26th highlighted at the 2016 American Wind Energy Association (AWEA) Conference, May 23-26th - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid

  10. Multi-walled carbon nanotube-induced gene expression in the mouse lung: Association with lung pathology

    SciTech Connect (OSTI)

    Pacurari, M.; Qian, Y.; Porter, D.W.; Wolfarth, M.; Wan, Y.; Luo, D.; Ding, M.; Castranova, V.; Guo, N.L.

    2011-08-15

    Due to the fibrous shape and durability of multi-walled carbon nanotubes (MWCNT), concerns regarding their potential for producing environmental and human health risks, including carcinogenesis, have been raised. This study sought to investigate how previously identified lung cancer prognostic biomarkers and the related cancer signaling pathways are affected in the mouse lung following pharyngeal aspiration of well-dispersed MWCNT. A total of 63 identified lung cancer prognostic biomarker genes and major signaling biomarker genes were analyzed in mouse lungs (n = 80) exposed to 0, 10, 20, 40, or 80 {mu}g of MWCNT by pharyngeal aspiration at 7 and 56 days post-exposure using quantitative PCR assays. At 7 and 56 days post-exposure, a set of 7 genes and a set of 11 genes, respectively, showed differential expression in the lungs of mice exposed to MWCNT vs. the control group. Additionally, these significant genes could separate the control group from the treated group over the time series in a hierarchical gene clustering analysis. Furthermore, 4 genes from these two sets of significant genes, coiled-coil domain containing-99 (Ccdc99), muscle segment homeobox gene-2 (Msx2), nitric oxide synthase-2 (Nos2), and wingless-type inhibitory factor-1 (Wif1), showed significant mRNA expression perturbations at both time points. It was also found that the expression changes of these 4 overlapping genes at 7 days post-exposure were attenuated at 56 days post-exposure. Ingenuity Pathway Analysis (IPA) found that several carcinogenic-related signaling pathways and carcinogenesis itself were associated with both the 7 and 11 gene signatures. Taken together, this study identifies that MWCNT exposure affects a subset of lung cancer biomarkers in mouse lungs. - Research Highlights: > Multi-Walled Carbon Nanotubes affect lung cancer biomarkers in mouse lungs. > The results suggest potentially harmful effects of MWCNT exposure on human lungs. > The results could potentially be used for

  11. QER - Comment of American Gas Association 3 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Gas Association 3 QER - Comment of American Gas Association 3 From: Clay, Kathryn [KClay@aga.org] Sent: Friday, October 10, 2014 9:47 PM To: QERcomments Cc: Wayland, Karen; Traweek, Lori; Pickett, Adonica (Renee); Sarkar, Reuben; Clay, Kathryn Subject: RE: AGA QER Comments Submission Attachments: AGA QER Comment Cover Letter NGVs Oct 10 2014.pdf; AGA comments - NGVs as part of a Low Carbon Future.pdf; AGFTransportationStudySept2012.pdf Dear Ms. Pickett: Attached please find AGA's comments on

  12. Comments of the American Public Gas Association on the Smart Grid RFI |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy the American Public Gas Association on the Smart Grid RFI Comments of the American Public Gas Association on the Smart Grid RFI Comments from The American Public Gas Association on the Smart Grid RFI: Addressing policy and logisitcal challenges to smart grid implementation The American Public Gas Association comments (17.7 KB) More Documents & Publications Okaloosa Gas District Smart Grid RFI: Addressing Policy and Logistical Challenges to Smart Grid Implementation

  13. QER- Comment of American Public Power Association 1

    Office of Energy Efficiency and Renewable Energy (EERE)

    Attached are the American Public Power Association 's (APPA) statement for the April 11 QER public meeting, Duane Highley's statement for the same meeting since we reference it, and Sue Kelly's (APPA President & CEO) testimony from last Thursday's (April 10) Senate Energy and Natural Resources Committee hearing entitled "Keeping the Lights On – Are We Doing Enough to Ensure the Reliability and Security of the US Electric Grid?" since her testimony covers everything in regards to this meeting. Thank you in advance for your consideration of our attached documents for the QER. Please let me know if you have any questions. Best, Seth Seth Voyles Director, Government Relations 1875 Connecticut Ave., NW, Suite 1200, Washington, D.C. 20009-5715 www.publicpower.org

  14. Y-12 receives American Heart Association award | Y-12 National Security

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Complex American ... Y-12 receives American Heart Association award Posted: November 22, 2012 - 9:00am Kathy Jetton, senior regional director of the American Heart Association, presents the Platinum award to Chuck Spencer, B&W Y-12 president and general manager. B&W Y-12 was honored as a Platinum-level award recipient of the American Heart Association's Fit-Friendly Companies program. Only eight companies in the Knoxville area are Fit-Friendly workplaces, and B&W Y-12 is the only

  15. 2007 American Coal Ash Association membership directory as of June 21, 2007

    SciTech Connect (OSTI)

    2007-07-01

    A listing of names, addresses, contact numbers and websites is given for 101 members of the American Coal Ash Association. Honorary members are also named. Included are power generation companies, combustion by-product manufacturers and university departments.

  16. African American Federal Executive Association, Inc. 9th Annual Training Workshop

    Broader source: Energy.gov [DOE]

    The African American Federal Executive Association, Inc. (AAFEA) will hold its 9th Annual Training Workshop (TW) September 16-17, 2013 in Washington, DC.  The theme of this year’s TW is “LEADING...

  17. Home Energy Score Program Overview for the American Gas Association Webinar (Text Version)

    Broader source: Energy.gov [DOE]

    Below is the text version of the webinar, Home Energy Score Program Overview for the American Gas Association, presented on July 30, 2013. In addition to this text version of the audio, you can...

  18. Remarks by Secretary Moniz to the American Association for the Advancement

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Science -- As prepared for delivery | Department of Energy to the American Association for the Advancement of Science -- As prepared for delivery Remarks by Secretary Moniz to the American Association for the Advancement of Science -- As prepared for delivery April 14, 2016 - 4:24pm Addthis Dr. Ernest Moniz Dr. Ernest Moniz Secretary of Energy Thank you for having me this morning, and thank you, Dr. [Rush] Holt. Today I want to talk primarily about the future of a set of institutions that

  19. Comment submitted by the North American Association of Food Equipment Manufacturers (NAFEM) regarding the Energy Star Verification Testing Program

    Broader source: Energy.gov [DOE]

    This document is a comment submitted by the North American Association of Food Equipment Manufacturers (NAFEM) regarding the Energy Star Verification Testing Program

  20. Predicting the Risk of Secondary Lung Malignancies Associated With Whole-Breast Radiation Therapy

    SciTech Connect (OSTI)

    Ng, John; Shuryak, Igor; Xu Yanguang; Clifford Chao, K.S.; Brenner, David J.; Burri, Ryan J.

    2012-07-15

    Purpose: The risk of secondary lung malignancy (SLM) is a significant concern for women treated with whole-breast radiation therapy after breast-conserving surgery for early-stage breast cancer. In this study, a biologically based secondary malignancy model was used to quantify the risk of secondary lung malignancies (SLMs) associated with several common methods of delivering whole-breast radiation therapy (RT). Methods and Materials: Both supine and prone computed tomography simulations of 15 women with early breast cancer were used to generate standard fractionated and hypofractionated whole-breast RT treatment plans for each patient. Dose-volume histograms (DVHs) of the ipsilateral breast and lung were calculated for each patient on each plan. A model of spontaneous and radiation-induced carcinogenesis was used to determine the relative risks of SLMs for the different treatment techniques. Results: A higher risk of SLMs was predicted for supine breast irradiation when compared with prone breast irradiation for both the standard fractionation and hypofractionation schedules (relative risk [RR] = 2.59, 95% confidence interval (CI) = 2.30-2.88, and RR = 2.68, 95% CI = 2.39-2.98, respectively). No difference in risk of SLMs was noted between standard fractionation and hypofractionation schedules in either the supine position (RR = 1.05, 95% CI = 0.97-1.14) or the prone position (RR = 1.01, 95% CI = 0.88-1.15). Conclusions: Compared with supine whole-breast irradiation, prone breast irradiation is associated with a significantly lower predicted risk of secondary lung malignancy. In this modeling study, fractionation schedule did not have an impact on the risk of SLMs in women treated with whole-breast RT for early breast cancer.

  1. Lung cancer-derived Dickkopf1 is associated with bone metastasis and the mechanism involves the inhibition of osteoblast differentiation

    SciTech Connect (OSTI)

    Chu, Tianqing; Teng, Jiajun; Jiang, Liyan; Zhong, Hua; Han, Baohui

    2014-01-17

    Highlights: DKK1 level was associated with NSCLC bone metastases. Lung tumor cells derived DKK1 inhibited osteoblast differentiation. Lung tumor cells derived DKK1 modulates ?-catenin and RUNX2. -- Abstract: Wnt/?-catenin signaling and Dickkopf1 (DKK1) play important roles in the progression of lung cancer, which preferably metastasizes to skeleton. But the role of them in bone dissemination is poorly understood. This study aims to define the role of DKK1 in lung cancer bone metastases and investigate the underlying mechanism. Our results demonstrated that DKK1 over-expression was a frequent event in non-small-cell lung cancer (NSCLC) blood samples, and serous DKK1 level was much higher in bone metastatic NSCLC compared to non-bone metastatic NSCLC. We also found that conditioned medium from DKK1 over-expressing lung cancer cells inhibited the differentiation of osteoblast, determined by alkaline phosphatase activity and osteocalcin secretion, whereas the conditioned medium from DKK1 silencing lung cancer cells exhibited the opposite effects. Mechanistically, DKK1 reduced the level of ?-catenin and RUNX2, as well as inhibiting the nuclear translocation of ?-catenin. Taken together, these results suggested that lung cancer-produced DKK1 may be an important mechanistic link between NSCLC and bone metastases, and targeting DKK1 may be an effective method to treat bone metastase of NSCLC.

  2. Source apportionment of particulate matter in the US and associations with lung inflammatory markers

    SciTech Connect (OSTI)

    Duvall, R.M.; Norris, G.A.; Dailey, L.A.; Burke, J.M.; McGee, J.K.; Gilmour, M.I.; Gordon, T.; Devlin, R.B.

    2008-07-01

    Size-fractionated particulate matter (PM) samples were collected from six U.S. cities and chemically analyzed as part of the Multiple Air Pollutant Study. Particles were administered to cultured lung cells and the production of three different proinflammatory markers was measured to explore the association between the health effect markers and PM. Ultrafine, fine, and coarse PM samples were collected between December 2003 and May 2004 over a 4-wk period in each city. Filters were pooled for each city and the PM samples were extracted then analyzed for trace metals, ions, and elemental carbon. Particle extracts were applied to cultured human primary airway epithelial cells, and the secreted levels of interleukin-8 (IL-8), heme oxygenase-1, and cyclooxygenase-2 were measured 1 and 24 h following exposure. Fine PM sources were quantified by the chemical mass balance (CMB) model. The relationship between toxicological measures, PM sources, and individual species were evaluated using linear regression. Ultrafine and fine PM mass were associated with increases in IL-8 (r{sup 2} = .80 for ultrafine and r{sup 2} = .52 for fine). Sources of fine PM and their relative contributions varied across the sampling sites and a strong linear association was observed between IL-8 and secondary sulfate from coal combustion (r{sup 2} = .79). Ultrafine vanadium, lead, copper, and sulfate were also associated with increases in IL-8. Increases in inflammatory markers were not observed for coarse PM mass and source markers. These findings suggest that certain PM size fractions and sources are associated with markers of lung injury or inflammation.

  3. QER - Comment of American Public Power Association 2 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    2 QER - Comment of American Public Power Association 2 From: Voyles, Seth [svoyles@publicpower.org] Sent: Sunday, May 18, 2014 2:22 PM To: QERcomments CC: Pechman, Carl; Mansueti, Lawrence Subject: Comments on Enhancing Energy Infrastructure Resiliency and Addressing Vulnerabilities Attachment: APPA Statement Submitted to First QER Mtg FINAL 4-15-14 docx.pdf; APPA Testimony for Senate Energy Committee Grid Security Hearing on Apri....pdf Attached are APPA's comments for the first public QER

  4. Blood cadmium levels are associated with a decline in lung function in males

    SciTech Connect (OSTI)

    Oh, Chang-Mo; Oh, In-Hwan; Lee, Jong-Keun; Park, Yoon Hyung; Choe, Bong-Keun; Yoon, Tai-Young; Choi, Joong-Myung

    2014-07-15

    Background: Cadmium exposure was found to cause a decline in lung function among the general population, but these findings were limited to smokers and gender differences were not explored. Objectives: To examine the relationship between cadmium and chronic obstructive pulmonary disease (COPD) according to gender and smoking status in Korea. Methods: Cross-sectional data from the Korean National Health and Nutrition Examination Survey from 2008 to 2011 were analyzed. COPD was defined by a pre-bronchodilator forced expiratory volume in 1 s divided by forced vital capacity of <0.70. A logistic regression model was used to elucidate the association between blood cadmium levels and COPD according to gender and smoking status. Results: Among 3861 eligible participants, 3622 were included in the analysis. The prevalence of COPD demonstrated an increasing trend in males (P for trend<0.001), but not in females (P for trend=0.67). After adjusting for covariates, a higher blood cadmium level, but within the normal range, was associated with COPD in males, including those who had never-smoked (P for trend <0.001 and P for trend=0.008). However, a higher blood cadmium level was not significantly associated with COPD in females, including those who had never smoked (P for trend=0.39 and P for trend=0.43). Conclusions: A higher blood cadmium level, within the normal range, was associated with COPD in males, including those who had never smoked. However, there was no significant association between blood cadmium levels and COPD in females. - Highlights: • Elevated blood cadmium level is associated with chronic obstructive pulmonary disease in male. • This association can be seen even in never smoked male. • However, this association is present only in male, but not in female.

  5. QER - Comment of American Public Power Association 5 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    5 QER - Comment of American Public Power Association 5 From: Voyles, Seth [svoyles@publicpower.org] Sent: Tuesday, July 15, 2014 2:30 PM To: QERcomments CC: Comment on the QER Public Meeting: Electricity Transmission, Storage and Distribution Attachment: APPA Statement for Portland QER Meeting - Final.docx; APPA WAPA JOT Comments -- 8.17.12.pdf; NRECA APPA ltr to Moniz final 1-31-2014.pdf; EXEC-2014-000699.pdf Attached are several documents for consideration for the QER Public Meeting:

  6. QER - Comment of American Public Power Association 7 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    7 QER - Comment of American Public Power Association 7 From: Voyles, Seth [svoyles@publicpower.org] Sent: Thursday, August 28, 2014 9:43 AM To: QERcomments Subject: Comment on: QER Public Meeting in Denver, CO: Gas-Electricity Interdependence Attachment: AttachB_Aspen_GasStorage2012.pdf; APPA Statement for the Record nat gas forum 2013-06-10.pdf; APPA Statement for the Record nat gas VERs hearing final 2013-05-09.pdf Attached are several documents for consideration for the QER Public Meeting on

  7. CDK-associated Cullin 1 promotes cell proliferation with activation of ERK1/2 in human lung cancer A549 cells

    SciTech Connect (OSTI)

    Chen, Tian Jun; Gao, Fei; Yang, Tian; Thakur, Asmitanand; Ren, Hui; Li, Yang; Zhang, Shuo; Wang, Ting; Chen, Ming Wei

    2013-07-19

    Highlights: CDK-associated Cullin 1 (CAC1) expression increases in human lung carcinoma. CAC1 promotes the proliferation of lung cancer A549 cells. CAC1 promotes human lung cancer A549 cell proliferation with activation of ERK1/2. -- Abstract: Lung cancer is one of the most common causes of cancer-related death in the world, but the mechanisms remain unknown. In this study, we investigated the expression of CDK-associated Cullin 1 (CAC1) in lung cancer, the effect of CAC1 on the proliferation of human lung cancer A549 cells, and the activation of signaling pathways of mitogen-activated protein kinases (MAPKs). Results showed that CAC1 expression was higher levels in human lung carcinoma than normal lung tissue, and CAC1 siRNA reduced the proliferation of lung cancer A549 cells by decreasing cell activity and cell division in vitro. The proportion of cells treated with CAC1 siRNA increased in the G1 phase and decreased in the S and G2/M phase, indicative of G1 cell cycle arrest. Furthermore, the proportions of early/late apoptosis in lung cancer A549 cells were enhanced with CAC1 siRNA treatment. It was also found that activation of extracellular signal-regulated protein kinase (ERK) and p38 signaling pathways were involved in the proliferation of A549 cells. After CAC1 siRNA treatment, p-ERK1/2 levels decreased, and meanwhile p-p38 level increased, A549 cell proliferation increased when ERK1/2 signaling is activated by PMA. Our findings demonstrated that CAC1 promoted the proliferation of human lung cancer A549 cells with activation of ERK1/2 signaling pathways, suggesting a potential cure target for treatment of human lung cancer.

  8. Prosperity Games prototyping with the American Electronics Association, March 8--9, 1994

    SciTech Connect (OSTI)

    Berman, M.; VanDevender, J.P.

    1994-08-01

    Prosperity Games are an outgrowth and adaptation of move/countermove and seminar War Games. Prosperity Games are simulations that explore complex issues in a variety of areas including economics, politics, sociology, environment, education and research. These issues can be examined from a variety of perspectives ranging from a global, macroeconomic and geopolitical viewpoint down to the details of customer/supplier/market interactions in specific industries. All Prosperity Games are unique in that both the game format and the player contributions vary from game to game. This report documents the Prosperity Game conducted under the sponsorship of the American Electronics Association in conjunction with the Electronics Subcommittee of the Civilian Industrial Technology Committee of the National Science and Technology Council. Players were drawn from government, national laboratories, and universities, as well as from the electronics industry. The game explored policy changes that could enhance US competitiveness in the manufacturing of consumer electronics. Two teams simulated a presidentially appointed commission comprised of high-level representatives from government, industry, universities and national laboratories. A single team represented the foreign equivalent of this commission, formed to develop counter strategies for any changes in US policies. The deliberations and recommendations of these teams provide valuable insights as to the views of this diverse group of decision makers concerning policy changes, foreign competition, and the development, delivery and commercialization of new technologies.

  9. Association Between White Blood Cell Count Following Radiation Therapy With Radiation Pneumonitis in Non-Small Cell Lung Cancer

    SciTech Connect (OSTI)

    Tang, Chad; Gomez, Daniel R. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Wang, Hongmei [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou (China); Levy, Lawrence B. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Zhuang, Yan [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Xu, Ting; Nguyen, Quynh; Komaki, Ritsuko [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Liao, Zhongxing, E-mail: zliao@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2014-02-01

    Purpose: Radiation pneumonitis (RP) is an inflammatory response to radiation therapy (RT). We assessed the association between RP and white blood cell (WBC) count, an established metric of systemic inflammation, after RT for non-small cell lung cancer. Methods and Materials: We retrospectively analyzed 366 patients with non-small cell lung cancer who received ?60 Gy as definitive therapy. The primary endpoint was whether WBC count after RT (defined as 2 weeks through 3 months after RT completion) was associated with grade ?3 or grade ?2 RP. Median lung volume receiving ?20 Gy (V{sub 20}) was 31%, and post-RT WBC counts ranged from 1.7 to 21.2 10{sup 3} WBCs/?L. Odds ratios (ORs) associating clinical variables and post-RT WBC counts with RP were calculated via logistic regression. A recursive-partitioning algorithm was used to define optimal post-RT WBC count cut points. Results: Post-RT WBC counts were significantly higher in patients with grade ?3 RP than without (P<.05). Optimal cut points for post-RT WBC count were found to be 7.4 and 8.0 10{sup 3}/?L for grade ?3 and ?2 RP, respectively. Univariate analysis revealed significant associations between post-RT WBC count and grade ?3 (n=46, OR=2.6, 95% confidence interval [CI] 1.4?4.9, P=.003) and grade ?2 RP (n=164, OR=2.0, 95% CI 1.2?3.4, P=.01). This association held in a stepwise multivariate regression. Of note, V{sub 20} was found to be significantly associated with grade ?2 RP (OR=2.2, 95% CI 1.2?3.4, P=.01) and trended toward significance for grade ?3 RP (OR=1.9, 95% CI 1.0-3.5, P=.06). Conclusions: Post-RT WBC counts were significantly and independently associated with RP and have potential utility as a diagnostic or predictive marker for this toxicity.

  10. Colorectal Histology Is Associated With an Increased Risk of Local Failure in Lung Metastases Treated With Stereotactic Ablative Radiation Therapy

    SciTech Connect (OSTI)

    Binkley, Michael S.; Trakul, Nicholas; Jacobs, Lisa Rose; Eyben, Rie von; Le, Quynh-Thu; Maxim, Peter G.; Loo, Billy W.; Shultz, David Benjamin; Diehn, Maximilian

    2015-08-01

    Purpose: Stereotactic ablative radiation therapy (SABR) is increasingly used to treat lung oligometastases. We set out to determine the safety and efficacy of this approach and to identify factors associated with outcomes. Methods and Materials: We conducted a retrospective study of patients treated with SABR for metastatic lung tumors at our institution from 2003 to 2014. We assessed the association between various patient and treatment factors with local failure (LF), progression, subsequent treatment, systemic treatment, and overall survival (OS), using univariate and multivariate analyses. Results: We identified 122 tumors in 77 patients meeting inclusion criteria for this study. Median follow-up was 22 months. The 12- and 24-month cumulative incidence rates of LF were 8.7% and 16.2%, respectively; the 24-month cumulative incidence rates of progression, subsequent treatment, and subsequent systemic treatment were 75.2%, 64.5%, and 35.1%, respectively. Twenty-four-month OS was 74.6%, and median OS was 36 months. Colorectal metastases had a significantly higher cumulative incidence of LF at 12 and 24 months (25.5% and 42.2%, respectively), than all other histologies (4.4% and 9.9%, respectively; P<.0004). The 24-month cumulative incidences of LF for colorectal metastases treated with a biologically effective dose at α/β = 10 (BED{sub 10}) of <100 Gy versus BED{sub 10} of ≥100 Gy were 62.5% and 16.7%, respectively (P=.08). Toxicity was minimal, with only a single grade 3 or higher event observed. Conclusions: SABR for metastatic lung tumors appears to be safe and effective with excellent local control, treatment-free intervals, and OS. An exception is metastases from colorectal cancer, which have a high LF rate consistent with a radioresistant phenotype, suggesting a potential role for dose escalation.

  11. Complications associated with brachytherapy alone or with laser in lung cancer

    SciTech Connect (OSTI)

    Khanavkar, B.; Stern, P.; Alberti, W.; Nakhosteen, J.A. )

    1991-05-01

    Relatively little has been reported about destruction through brachytherapy of mucosa-perforating and extraluminary tumors with probable large vessel involvement causing major hemorrhagic or fistular complications. We report 12 patients subjected to laser and brachytherapy for centrally occluding lung cancer, whom we have periodically followed up from June 1986 until they died. Although all laser procedures were free from complications, necrotic cavitation in five cases, two of which were accompanied by large bronchoesophageal fistulas, and massive fatal hemoptysis occurred in six. Minor complications included radiation mucositis (two), noncritical mucosal scarring (two), and cough (four). Characteristics that will identify patients at risk of developing fatal hemoptysis and fistulas should be better defined by imaging and endoscopic techniques. In such cases, modifying the protocol or using alternative procedures should be considered. Minor complications, such as cough, can be avoided by using topical steroid therapy (eg, beclomethasone dipropionate).

  12. Small Wind Electric Systems: A Guide for the American Corn Growers Association

    U.S. Energy Information Administration (EIA) Indexed Site

    Guide Produced for the American Corn Growers Foundation Small Wind Electric Systems Small Wind Electric Systems U.S. Department of Energy Energy Efficiency and Renewable Energy Wind and Hydropower Technologies Program Small Wind Electric Systems Cover photo: This AOC 15/50 wind turbine on a farm in Clarion, Iowa, saves the Clarion-Goldfield Community School about $9,000 per year on electrical purchase and provides a part of the school's science curriculum. Photo credit - Robert Olson/PIX11649 A

  13. EV Community Readiness projects: American Lung Association of the Southwest (CO); Oregon Business Development Department (OR, WA)

    Broader source: Energy.gov [DOE]

    2013 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting

  14. Downregulated TIPE2 is associated with poor prognosis and promotes cell proliferation in non-small cell lung cancer

    SciTech Connect (OSTI)

    Li, Yuexia; Li, Xiaohui; Liu, Gang; Sun, Rongqing; Wang, Lirui; Wang, Jing; Wang, Hongmin

    2015-01-30

    Highlights: • TIPE2 is down-regulated in NSCLC tissues. • TIPE2 inhibits NSCLC cell proliferation, colony formation and invasion. • TIPE2 reduces the anti-apoptotic Bcl-XL protein and mesenchymal marker N-cadherin expression. - Abstract: The present study aims to investigate the expression pattern of TIPE2 protein and its clinical significance in human non-small cell lung cancer (NSCLC). We investigated the expression levels of TIPE2 in 96 NSCLC tumor samples by immunohistochemistry and then analyzed its clinical significance. Furthermore, the role of TIPE2 on the biological properties of the NSCLC cell line H1299 and A549 was experimentally tested in vitro and in vivo. We found that the expression level of TIPE2 was significantly higher in normal lung tissues compared with NSCLC tissues (P < 0.001), and TIPE2 downregulation was significantly correlated with advanced TNM stage (P = 0.006). TIPE2 expression was lower in lung cancer cell lines than normal bronchial cell line HBE. Transfection of TIPE2 plasmid was performed in H1299 and A549 cells. TIPE2 overexpression inhibited lung cancer cell proliferation, colony formation and cell invasive in vitro, and prevented lung tumor growth in vivo. In addition, TIPE2 transfection reduced the anti-apoptotic Bcl-XL protein and mesenchymal marker N-cadherin expression. Taken together, our results demonstrate that TIPE2 might serve as a tumor suppressor in NSCLC progression.

  15. Functional Promoter Variant rs2868371 of HSPB1 Is Associated With Risk of Radiation Pneumonitis After Chemoradiation for Non-Small Cell Lung Cancer

    SciTech Connect (OSTI)

    Pang, Qingsong; Department of Radiation Oncology and Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin ; Wei, Qingyi; Xu, Ting; Yuan, Xianglin; Lopez Guerra, Jose Luis; Levy, Lawrence B.; Liu, Zhensheng; Gomez, Daniel R.; Zhuang, Yan; Wang, Li-E.; Mohan, Radhe; Komaki, Ritsuko; Liao, Zhongxing

    2013-04-01

    Purpose: To date, no biomarkers have been found to predict, before treatment, which patients will develop radiation pneumonitis (RP), a potentially fatal toxicity, after chemoradiation for lung cancer. We investigated potential associations between single nucleotide polymorphisms (SNPs) in HSPB1 and risk of RP after chemoradiation for non-small cell lung cancer (NSCLC). Methods and Materials: Subjects were patients with NSCLC treated with chemoradiation at 1 institution. The training data set comprised 146 patients treated from 1999 to July 2004; the validation data set was 125 patients treated from August 2004 to March 2010. We genotyped 2 functional SNPs of HSPB1 (rs2868370 and rs2868371) from all patients. We used Kaplan-Meier analysis to assess the risk of grade ≥2 or ≥3 RP in both data sets and a parametric log-logistic survival model to evaluate the association of HSPB1 genotypes with that risk. Results: Grade ≥3 RP was experienced by 13% of those with CG/GG and 29% of those with CC genotype of HSPB1 rs2868371 in the training data set (P=.028); corresponding rates in the validation data set were 2% CG/GG and 14% CC (P=.02). Univariate and multivariate analysis confirmed the association of CC of HSPB1 rs2868371 with higher risk of grade ≥3 RP than CG/GG after adjustment for sex, age, performance status, and lung mean dose. This association was validated both in the validation data set and with Harrell's C statistic. Conclusions: The CC genotype of HSPB1 rs2868371 was associated with severe RP after chemoradiation for NSCLC.

  16. SUPPORT FOR CHEMISTRY SYMPOSIA AT THE 2011 AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE MEETING FEBRUARY 17-21, 2011

    SciTech Connect (OSTI)

    Prof. Charles Casey, University of Wisconsin-Madison

    2011-08-20

    This proposal supported Chemistry Symposia at the 2011 American Association for the Advancement of Science (AAAS) Meeting in Washington, DC February 17-21, 2011. The Chemistry Section of AAAS presented an unusually strong set of symposia for the 2011 AAAS meeting to help celebrate the 2011 International Year of Chemistry. The AAAS meeting provided an unusual opportunity to convey the excitement and importance of chemistry to a very broad audience and allowed access to a large contingent of the scientific press. Excellent suggestions for symposia were received from AAAS Chemistry Fellows and from the chairs of the American Chemical Society Technical Divisions. The AAAS Chemistry executive committee selected topics that would have wide appeal to scientists, the public, and the press for formal proposals of symposia. The symposia proposals were peer reviewed by AAAS. The Chemistry Section made a strong case to the program selection committee for approval of the chemistry symposia and 6 were approved for the 2011 annual meeting. The titles of the approved symposia were: (1) Powering the Planet: Generation of Clean Fuels from Sunlight and Water, (2) Biological Role and Consequences of Intrinsic Protein Disorder, (3) Chemically Speaking: How Organisms Talk to Each Other, (4) Molecular Self-Assembly and Artificial Molecular Machines, (5) Frontiers in Organic Materials for Information Processing, Energy and Sensors, and (6) Celebrating Marie Curie's 100th Anniversary of Her Nobel Prize in Chemistry. The Chemistry Section of AAAS is provided with funds to support only 1-2 symposia a year. Because of the much greater number of symposia approved in conjunction with observance of the 2011 International Year of Chemistry, additional support was sought from DOE to help support the 30 invited speakers and 8 symposia moderators/organizers. Support for the symposia provided the opportunity to highlight the excitement of current chemical research, to educate the public about the

  17. AMERICAN STATISTICAL ASSOCIATION

    U.S. Energy Information Administration (EIA) Indexed Site

    ... The t-statistics test significant and those t-statistics are to the actual regression ... on the NEMS, you've got to test this with real live data eventually to see how it's doing. ...

  18. AMERICAN STATISTICAL ASSOCIATION

    U.S. Energy Information Administration (EIA) Indexed Site

    ... just to develop the disclosure limitation methods to implement them, to test them, to make sure that they were working properly and there wasn't any change of any disclosure. ...

  19. AMERICAN STATISTICAL ASSOCIATION

    U.S. Energy Information Administration (EIA) Indexed Site

    ... If you want to just test your theory and run that -- and run it by data that's 25 years ... They kind of are still looking at a small test -- MR. BLAIR: This is in the Agency? ...

  20. AMERICAN STATISTICAL ASSOCIATION

    U.S. Energy Information Administration (EIA) Indexed Site

    ... 202-464-2400 800-522-2382 157 1 but a test of the conditions under which a peak 2 oil ... And as 20 just as sort of fun AB test sometime, you 21 might try organization by price ...

  1. AMERICAN STATISTICAL ASSOCIATION (ASA)

    U.S. Energy Information Administration (EIA) Indexed Site

    ... team to EIA products and services, data analysis, forecast, education, and documentation. ... the use or misuse of review recommendations that should be considered in the project plan? ...

  2. Jefferson Lab Leadership Council - Dr. Allison Lung

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Associate Director, Dr. Allison Lung Allison Lung Associate Director, 12 GeV Upgrade Project Allison Lung was appointed the assistant director for the Thomas Jefferson National Accelerator Facility in October 2002. As assistant director, Lung is responsible for formulating and leading the JLab Continual Improvement Program, and responding to requests from JLab stakeholders. She organizes support and documentation for funding campaigns and collaborates closely with the lab director in matters

  3. Associations of symptoms related to isocyanate, ureaformol, and formophenolic exposures with respiratory symptoms and lung function in coal miners

    SciTech Connect (OSTI)

    Bertrand, J.P.; Simon, V.; Chau, N.

    2007-04-15

    The respiratory effects of diphenylmethane diisocyanate (MDI)-based resins and ureaformol- and formophenolic-based resins, used in coal mining, are unknown. This cross-sectional study of 354 miners evaluated respiratory health in miners with MDI-related symptoms (IS) and ureaformol/formophenolic-related symptoms (UFS). The protocol included clinical examination, chest radiograph, questionnaire on respiratory symptoms, smoking habit, job history, resin handling, and spirometry. Resin handling concerned 27.7% of the miners. IS affected 5.6%, and 1.4% also after work. UFS affected 22.6%, and 2.3% also after work. Wheezing affected 35.6%; chronic cough, expectoration, or bronchitis about 10%; dyspnea 5.4%; and asthma 2.8%. The miners with UFS had significantly more frequent chronic cough, expectoration, chronic bronchitis, dyspnea, and wheezing, whereas those with IS at and after work had markedly lower FVC, FEV1, MMEF, FEF50% and FEF25%. These findings raise the possibility of deleterious effects of exposures to MDI and ureaformol/ ormophenolic resins on respiratory health and lung function in coal miners during their working life.

  4. Influence of radiation therapy on the lung-tissue in breast cancer patients: CT-assessed density changes and associated symptoms

    SciTech Connect (OSTI)

    Rotstein, S.; Lax, I.; Svane, G. )

    1990-01-01

    The relative electron density of lung tissue was measured from computer tomography (CT) slices in 33 breast cancer patients treated by various techniques of adjuvant radiotherapy. The measurements were made before radiotherapy, 3 months and 9 months after completion of radiation therapy. The changes in lung densities at 3 months and 9 months were compared to radiation induced radiological (CT) findings. In addition, subjective symptoms such as cough and dyspnoea were assessed before and after radiotherapy. It was observed that the mean of the relative electron density of lung tissue varied from 0.25 when the whole lung was considered to 0.17 when only the anterior lateral quarter of the lung was taken into account. In patients with positive radiological (CT) findings the mean lung density of the anterior lateral quarter increased 2.1 times 3 months after radiotherapy and was still increased 1.6 times 6 months later. For those patients without findings, in the CT pictures the corresponding values were 1.2 and 1.1, respectively. The standard deviation of the pixel values within the anterior lateral quarter of the lung increased 3.8 times and 3.2 times at 3 months and 9 months, respectively, in the former group, as opposed to 1.2 and 1.1 in the latter group. Thirteen patients had an increase in either cough or dyspnoea as observed 3 months after completion of radiotherapy. In eleven patients these symptoms persisted 6 months later. No significant correlation was found between radiological findings and subjective symptoms. However, when three different treatment techniques were compared among 29 patients the highest rate of radiological findings was observed in patients in which the largest lung volumes received the target dose. A tendency towards an increased rate of subjective symptoms was also found in this group.

  5. Buy American Guidance Documents

    Office of Energy Efficiency and Renewable Energy (EERE)

    Projects funded by the American Recovery and Reinvestment Act of 2009 (Recovery Act) were required to follow the Buy American Provision. Below are Buy American guidance documents.

  6. Statistical Association

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Kelly named Fellow of the American Statistical Association August 2, 2016 The American Statistical Association (ASA) has honored Elizabeth Kelly of the Lab's Statistical Sciences group with the title of Fellow. The ASA recognized her for providing exemplary statistical leadership of and collaboration on multidisciplinary teams dealing with environmental restoration, weapon quality, and nuclear materials storage to ensure the safety and security of the Nation. She will receive the Fellow award at

  7. Sandia Energy - American Institute of Aeronautics and Astronautics...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    as Associate Fellow Home Renewable Energy Energy News Wind Energy News & Events American Institute of Aeronautics and Astronautics Elects Sandian as Associate Fellow Previous...

  8. Joshua DeLung

    Broader source: Energy.gov [DOE]

    Joshua DeLung is an Account Manager at ENC Marketing & Communications and the Executive Editor at Relatively Journalizing.

  9. Higher Biologically Effective Dose of Radiotherapy Is Associated With Improved Outcomes for Locally Advanced Non-Small Cell Lung Carcinoma Treated With Chemoradiation: An Analysis of the Radiation Therapy Oncology Group

    SciTech Connect (OSTI)

    Machtay, Mitchell; Movsas, Benjamin; Paulus, Rebecca; Gore, Elizabeth M.; Komaki, Ritsuko; Albain, Kathy; Sause, William T.; Curran, Walter J.

    2012-01-01

    Purpose: Patients treated with chemoradiotherapy for locally advanced non-small-cell lung carcinoma (LA-NSCLC) were analyzed for local-regional failure (LRF) and overall survival (OS) with respect to radiotherapy dose intensity. Methods and Materials: This study combined data from seven Radiation Therapy Oncology Group (RTOG) trials in which chemoradiotherapy was used for LA-NSCLC: RTOG 88-08 (chemoradiation arm only), 90-15, 91-06, 92-04, 93-09 (nonoperative arm only), 94-10, and 98-01. The radiotherapeutic biologically effective dose (BED) received by each individual patient was calculated, as was the overall treatment time-adjusted BED (tBED) using standard formulae. Heterogeneity testing was done with chi-squared statistics, and weighted pooled hazard ratio estimates were used. Cox and Fine and Gray's proportional hazard models were used for OS and LRF, respectively, to test the associations between BED and tBED adjusted for other covariates. Results: A total of 1,356 patients were analyzed for BED (1,348 for tBED). The 2-year and 5-year OS rates were 38% and 15%, respectively. The 2-year and 5-year LRF rates were 46% and 52%, respectively. The BED (and tBED) were highly significantly associated with both OS and LRF, with or without adjustment for other covariates on multivariate analysis (p < 0.0001). A 1-Gy BED increase in radiotherapy dose intensity was statistically significantly associated with approximately 4% relative improvement in survival; this is another way of expressing the finding that the pool-adjusted hazard ratio for survival as a function of BED was 0.96. Similarly, a 1-Gy tBED increase in radiotherapy dose intensity was statistically significantly associated with approximately 3% relative improvement in local-regional control; this is another way of expressing the finding that the pool-adjusted hazard ratio as a function of tBED was 0.97. Conclusions: Higher radiotherapy dose intensity is associated with improved local-regional control and

  10. Legacy Guidance: The Buy American Provision of the Recovery Act |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Legacy Guidance: The Buy American Provision of the Recovery Act Legacy Guidance: The Buy American Provision of the Recovery Act Projects funded by the American Recovery and Reinvestment Act of 2009 (Recovery Act) were required to follow the Buy American Provision. This guidance only applied to Funding Opportunity Announcements (FOAs) associated with the Recovery Act. If the FOA received another source of funding-not from the Recovery Act-then the Buy America provision

  11. White Paper Developed by the American Gas Association and American...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... except natural draft" and "Gas-fired- natural draft." 12 This ... without undue burden. 14 1. Packaged Terminal Air Conditioners (PTAC) and Heat Pumps (PTHP). ...

  12. American Recovery and Reinvestment Act

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    American Recovery and Reinvestment Act American Recovery and Reinvestment Act LANL was able to accelerate demolition and cleanup thanks to a 212 million award from the American...

  13. Tiny plastic lung mimics human pulmonary function

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Tiny plastic lung mimics human pulmonary function Tiny plastic lung mimics human pulmonary function Scientists are developing a miniature, tissue-engineered artificial lung that ...

  14. Lung pair phantom

    DOE Patents [OSTI]

    Olsen, Peter C.; Gordon, N. Ross; Simmons, Kevin L.

    1993-01-01

    The present invention is a material and method of making the material that exhibits improved radiation attenuation simulation of real lungs, i.e., an "authentic lung tissue" or ALT phantom. Specifically, the ALT phantom is a two-part polyurethane medium density foam mixed with calcium carbonate, potassium carbonate if needed for K-40 background, lanthanum nitrate, acetone, and a nitrate or chloride form of a radionuclide. This formulation is found to closely match chemical composition and linear attenuation of real lungs. The ALT phantom material is made according to established procedures but without adding foaming agents or preparing thixotropic concentrate and with a modification for ensuring uniformity of density of the ALT phantom that is necessary for accurate simulation. The modification is that the polyurethane chemicals are mixed at a low temperature prior to pouring the polyurethane mixture into the mold.

  15. Lung pair phantom

    DOE Patents [OSTI]

    Olsen, P.C.; Gordon, N.R.; Simmons, K.L.

    1993-11-30

    The present invention is a material and method of making the material that exhibits improved radiation attenuation simulation of real lungs, i.e., an ``authentic lung tissue`` or ALT phantom. Specifically, the ALT phantom is a two-part polyurethane medium density foam mixed with calcium carbonate, potassium carbonate if needed for K-40 background, lanthanum nitrate, acetone, and a nitrate or chloride form of a radionuclide. This formulation is found to closely match chemical composition and linear attenuation of real lungs. The ALT phantom material is made according to established procedures but without adding foaming agents or preparing thixotropic concentrate and with a modification for ensuring uniformity of density of the ALT phantom that is necessary for accurate simulation. The modification is that the polyurethane chemicals are mixed at a low temperature prior to pouring the polyurethane mixture into the mold.

  16. Lung inflammation biomarkers and lung function in children chronically exposed to arsenic

    SciTech Connect (OSTI)

    Olivas-Calderón, Edgar; Recio-Vega, Rogelio; Gandolfi, A. Jay; Lantz, R. Clark; González-Cortes, Tania; Gonzalez-De Alba, Cesar; Froines, John R.; Espinosa-Fematt, Jorge A.

    2015-09-01

    Evidence suggests that exposure to arsenic in drinking water during early childhood or in utero has been associated with an increase in respiratory symptoms or diseases in the adulthood, however only a few studies have been carried out during those sensitive windows of exposure. Recently our group demonstrated that the exposure to arsenic during early childhood or in utero in children was associated with impairment in the lung function and suggested that this adverse effect could be due to a chronic inflammation response to the metalloid. Therefore, we designed this cross-sectional study in a cohort of children associating lung inflammatory biomarkers and lung function with urinary As levels. A total of 275 healthy children were partitioned into four study groups according with their arsenic urinary levels. Inflammation biomarkers were measured in sputum by ELISA and the lung function was evaluated by spirometry. Fifty eight percent of the studied children were found to have a restrictive spirometric pattern. In the two highest exposed groups, the soluble receptor for advanced glycation end products' (sRAGE) sputum level was significantly lower and matrix metalloproteinase-9 (MMP-9) concentration was higher. When the biomarkers were correlated to the urinary arsenic species, negative associations were found between dimethylarsinic (DMA), monomethylarsonic percentage (%MMA) and dimethylarsinic percentage (%DMA) with sRAGE and positive associations between %DMA with MMP-9 and with the MMP-9/tissue inhibitor of metalloproteinase (TIMP-1) ratio. In conclusion, chronic arsenic exposure of children negatively correlates with sRAGE, and positively correlated with MMP-9 and MMP-9/TIMP-1 levels, and increases the frequency of an abnormal spirometric pattern. Arsenic-induced alterations in inflammatory biomarkers may contribute to the development of restrictive lung diseases. - Highlights: • First study in children evaluating lung inflammatory biomarkers and As levels

  17. Early Lung Cancer Detection Program

    Broader source: Energy.gov [DOE]

    Since 2000, DOE has made screening for occupational lung cancer with low-dose helical computed tomography (CT) scans available to workers at high risk for lung cancer. Because former workers undertook essential activities to fulfill the Department's mission, many of them were at risk for lung cancer.

  18. Terwilliger named American Crystallographic Association Fellow

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    over 140 publications, Terwilliger has published in Nature, Science, Proceedings of the National Academy of Sciences, Nature Biotechnology, and other major journals. He is a...

  19. Los Alamos' Terwilliger named American Crystallographic Association...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the structures of molecules using X-ray lasers and new methods for obtaining clear ... Many members of the ACA look at the shapes of protein molecules, which are the molecular ...

  20. Los Alamos' Terwilliger named American Crystallographic Association

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the structures of molecules using X-ray lasers and new methods for obtaining clear ... the ACA look at the shapes of protein molecules, which are the molecular machines of life. ...

  1. QER- Comment of American Gas Association 1

    Office of Energy Efficiency and Renewable Energy (EERE)

    Attached please find AGA's comments on methane emissions issues in the first phase of the DOE Quadrennial Energy Review (QER), consisting of a cover letter and attachments. Dr. Kathryn Clay will be submitting AGA's comments on other aspects of the QER. Please let me know if you have any questions.

  2. QER- Comment of American Gas Association 4

    Office of Energy Efficiency and Renewable Energy (EERE)

    From: Peterson, Christopher (EIA)Sent: Tuesday, October 14, 2014 12:11 PMTo: Pierpoint, LaraSubject: FW: AGA comments to QER: Natural Gas Emissions Section

  3. Native American Finance Officers Association Conference

    Broader source: Energy.gov [DOE]

    This event will take place on March 20-21, 2012, in New Orleans, Louisiana. Learn more and register on the NAFOA website.

  4. QER- Comment of American Gas Association 2

    Office of Energy Efficiency and Renewable Energy (EERE)

    Attached please find AGA's comments relating to critical issues facing the natural gas distribution industry, which we believe could be usefully addressed in the first phase of the DOE Quadrennial Energy Review (QER). Our comments as submitted here consist of a cover letter and four additional attachments. My colleague Pam Lacey has previously submitted AGA's comments relating to methane emissions under separate cover.

  5. Moore honored with American Statistical Association award

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Before his death in 1991, Professor Owen was the Distinguished Professor of Statistics at Southern Methodist University in Dallas, Texas. His illustrious career serves as the ...

  6. American Public Power Association Statement Quadrennial Energy...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... market is a mechanism to provide revenue to a power plant owner to stand ready to supply power when needed, or to customers who agree to curtail their load (i.e., demand response). ...

  7. American Gas Association Ex Parte Communication | Department...

    Office of Environmental Management (EM)

    and staff of the U.S. Department of Energy (DOE) to discuss the notice of proposed rulemaking (NOPR) on minimum energy efficiency standards for residential natural gas furnaces. ...

  8. Buy American Program Guidance

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    PROJECTS FUNDED BY THE AMERICAN RECOVERY AND REINVESTMENT ACT OF 2009 AND ADMINISTERED BY THE OFFICE OF ENERGY EFFICIENCY AND RENEWABLE ENERGY NOTICE EFFECTIVE DATE: December 17, 2009 SUBJECT: GUIDANCE ON THE BUY AMERICAN PROVISIONS AS APPLIED TO ENERGY EFFICIENCY AND RENEWABLE ENERGY PROJECTS FUNDED BY THE AMERICAN RECOVERY AND REINVESTMENT ACT OF 2009 AND ADMINISTERED BY THE OFFICE OF ENERGY EFFICIENCY AND RENEWABLE ENERGY PURPOSE: Provides guidance to financial assistance recipients regarding

  9. Native American Venture Acceleration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Native American Venture Acceleration Fund provides boost to six regional businesses February 26, 2013 LANS, LANL fostering economic development in Northern New Mexico LOS ALAMOS, New Mexico, Feb. 26, 2013-Six Native American businesses received grants through a new Native American Venture Acceleration Fund created by Los Alamos National Security, LLC (LANS) and the Regional Development Corporation. The grants are designed to help the recipients create jobs, increase their revenue base and help

  10. American Venture Acceleration Fund

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    regional businesses receive Native American Venture Acceleration Fund grants February 1, 2016 Investing in Northern New Mexico's economy through jobs, new revenue LOS ALAMOS, N.M., Feb. 1, 2016-Four Northern New Mexico Native American- owned and operated businesses received a total of $60,000 in grants through a Native American Venture Acceleration Fund created by Los Alamos National Security, LLC (LANS) and the Regional Development Corporation. The grants are designed to help the recipients

  11. Native American Heritage Month

    Broader source: Energy.gov [DOE]

    This month, we celebrate the rich heritage and myriad contributions of American Indians and Alaska Natives, and we rededicate ourselves to supporting tribal sovereignty, tribal self-determination,...

  12. Petroleo moderno. [Latin American

    SciTech Connect (OSTI)

    Berger, B.; Anderson, K.

    1980-01-01

    The Latin American petroleum industry is discussed. Emphasis is placed upon the business aspects of the industry as well as the present stage of industrial development. (JMT)

  13. Crystallographic Association Fellow

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    named American Crystallographic Association Fellow January 4, 2013 The American Crystallographic Association (ACA) honored Thomas Terwilliger of LANL's Biosecurity and Public Health group with the rank of Fellow. He was inducted during the ACA annual meeting in Boston. The ACA Fellows program celebrates the excellence of its members and promotes their recognition worldwide. ACA Fellows serve as scientific ambassadors to the broader scientific community and the general public to advance science

  14. Historical review of lung counting efficiencies for low energy photon emitters

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Jeffers, Karen L.; Hickman, David P.

    2014-03-01

    This publication reviews the measured efficiency and variability over time of a high purity planar germanium in vivo lung count system for multiple photon energies using increasingly thick overlays with the Lawrence Livermore Torso Phantom. Furthermore, the measured variations in efficiency are compared with the current requirement for in vivo bioassay performance as defined by the American National Standards Institute Standard.

  15. American Photovoltaics | Open Energy Information

    Open Energy Info (EERE)

    Photovoltaics Jump to: navigation, search Logo: American Photovoltaics Name: American Photovoltaics Place: Houston, Texas Zip: 77002 Region: Texas Area Sector: Solar Product: Will...

  16. QER- Comment of American Hydrogen Northeast, Inc.

    Office of Energy Efficiency and Renewable Energy (EERE)

    Dear Sir or Madam, Attached please find the Hydrogen Association and the American Hydrogen Northeast,inc's Comments on the first round of QER review. I wish to thank Secretary Moniz and Senator Reed for attending the Providence hearing and providing this opportunity to submit these comments.

  17. American Nuclear Society Awards

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ans awards American Nuclear Society Awards Established in 1999 by the Fusion Energy Division of the American Nuclear Society (ANS) and named after LLNL's co-founder, the Edward Teller Medal recognizes pioneering research and leadership in the use of laser and ion-particle beams to produce unique high-temperature and high-density matter for scientific research and for controlled thermonuclear fusion. Name Year Name of Award and Citation Susana Reyes 2012 Mary Jane Oestmann Professional Women's

  18. American Physical Society Awards

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    aps awards American Physical Society Awards American Physical Society (APS) is one of the most important professional societies for gauging the quality of R&D done at the Laboratory. The APS sponsors a number of awards including the John Dawson Award of Excellence in Plasma Physics, James Clerk Maxwell Prize for Plasma Physics, as well as Dinstinguised Lectuerer and Doctoral Dissertation prizes. Name Year Name of Award and Citation Yu-hsin Chen 2012 Marshall N. Rosenbluth Outstanding

  19. American Physical Society Fellows

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    aps fellows American Physical Society Fellows American Physical Society (APS) Fellowships recognize those who have made advances in knowledge through original research or have made significant and innovative contributions in the application of physics to science and technology. Each year, no more than one-half of one percent of APS's current membership is recognized by their peers for election to the status of Fellow. The hundred-year-old society numbers tens of thousands of physicists

  20. American Process - Alpena Biorefinery

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Sugar is the New Crude® 1 American Process - Alpena Biorefinery Lessons Learned: Theodora Retsina CEO American Process Company History * Conducted over 400 projects, in USA, Canada, Brazil, Europe, Australia * In more than 150 forest industry plants * Performed O&M services 1995 - 2010 * Designed EPC and operated power cogeneration facilities "across the fence" * Designed projects for mill shutdown installations 1999 - 2010 * Invested in biorefinery R&D - Over 48 patents

  1. American Chemical Society Fellows

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    selected as American Chemical Society Fellows August 7, 2014 Chamberlin and Porterfield named ACS Fellows LOS ALAMOS, N.M., Aug. 7, 2014-Rebecca Chamberlin and Donivan Porterfield, both of Los Alamos National Laboratory's Actinide Analytical Chemistry group, have been selected as a 2014 Fellows of the American Chemical Society (ACS). Rebecca Chamberlin An inorganic chemist and radiochemist, Chamberlin is currently the co-principal investigator for development of novel microreactor-based systems

  2. American Physical Society

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Los Alamos scientists honored by American Physical Society November 12, 2015 LOS ALAMOS, N.M., Nov. 12, 2015-Ten Los Alamos National Laboratory scientists are new Fellows of the American Physical Society. Tariq Aslam, Steven Batha, Eric Bauer, Hou-Tong Chen, Diego Alejandro Dalvit, Dinh Nguyen, Alan Perelson, Filip Ronning, Alexander Saunders and Glen Wurden were named this week by the national organization. "We're extremely pleased that the technical accomplishments of our talented staff

  3. American Physical Society awards

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    awards fellowships to Los Alamos scientists December 18, 2012 American Physical Society Awards Fellowships to Los Alamos Scientists LOS ALAMOS, NEW MEXICO, December 18, 2012-Ten scientists at Los Alamos National Laboratory are being inducted into the ranks of fellowship in the American Physical Society (APS) for 2012. The criterion for election as an APS Fellow is exceptional contributions to the physics enterprise; such as performing outstanding physics research, important applications of

  4. American Venture Acceleration Fund

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    February 4, 2014 LANS, LANL fostering economic development in Northern New Mexico LOS ALAMOS, N.M., Feb. 4, 2014-Six Northern New Mexico Native American-owned and operated businesses received a total of $60,000 in grants through a new Native American Venture Acceleration Fund created by Los Alamos National Security, LLC (LANS) and the Regional Development Corporation. The grants are designed to help the recipients create jobs, increase their revenue base and help diversify the area economy. - 2

  5. Economic Impact of 8(a) and Native American Contractors

    Broader source: Energy.gov [DOE]

    Editor's Note: This blog post was guest written by Jennine Elias, Director of External Affairs for the Native American Contractors Association (www.nativecontractors.org)

  6. Residential radon and lung cancer incidence in a Danish cohort

    SciTech Connect (OSTI)

    Braeuner, Elvira V.; Andersen, Claus E.; Sorensen, Mette; Jovanovic Andersen, Zorana; Center for Epidemiology Screening, Department of Public Health, University of Copenhagen ; Gravesen, Peter; Ulbak, Kaare; Hertel, Ole; Pedersen, Camilla; Overvad, Kim; Tjonneland, Anne; Raaschou-Nielsen, Ole

    2012-10-15

    High-level occupational radon exposure is an established risk factor for lung cancer. We assessed the long-term association between residential radon and lung cancer risk using a prospective Danish cohort using 57,053 persons recruited during 1993-1997. We followed each cohort member for cancer occurrence until 27 June 2006, identifying 589 lung cancer cases. We traced residential addresses from 1 January 1971 until 27 June 2006 and calculated radon at each of these addresses using information from central databases regarding geology and house construction. Cox proportional hazards models were used to estimate incidence rate ratios (IRR) and 95% confidence intervals (CI) for lung cancer risk associated with residential radon exposure with and without adjustment for sex, smoking variables, education, socio-economic status, occupation, body mass index, air pollution and consumption of fruit and alcohol. Potential effect modification by sex, traffic-related air pollution and environmental tobacco smoke was assessed. Median estimated radon was 35.8 Bq/m{sup 3}. The adjusted IRR for lung cancer was 1.04 (95% CI: 0.69-1.56) in association with a 100 Bq/m{sup 3} higher radon concentration and 1.67 (95% CI: 0.69-4.04) among non-smokers. We found no evidence of effect modification. We find a positive association between radon and lung cancer risk consistent with previous studies but the role of chance cannot be excluded as these associations were not statistically significant. Our results provide valuable information at the low-level radon dose range.

  7. H-1 Nuclear Magnetic Resonance Metabolomics Analysis Identifies Novel Urinary Biomarkers for Lung Function

    SciTech Connect (OSTI)

    MCClay, Joseph L.; Adkins, Daniel E.; Isern, Nancy G.; O'Connell, Thomas M.; Wooten, Jan B.; Zedler, Barbara K.; Dasika, Madhukar S.; Webb, B. T.; Webb-Robertson, Bobbie-Jo M.; Pounds, Joel G.; Murrelle, Edward L.; Leppert, Mark F.; van den Oord, Edwin J.

    2010-06-04

    Chronic obstructive pulmonary disease (COPD), characterized by chronic airflow limitation, is a serious and growing public health concern. The major environmental risk factor for COPD is tobacco smoking, but the biological mechanisms underlying COPD are not well understood. In this study, we used proton nuclear magnetic resonance (1H-NMR) spectroscopy to identify and quantify metabolites associated with lung function in COPD. Plasma and urine were collected from 197 adults with COPD and from 195 adults without COPD. Samples were assayed using a 600 MHz NMR spectrometer, and the resulting spectra were analyzed against quantitative spirometric measures of lung function. After correcting for false discoveries and adjusting for covariates (sex, age, smoking) several spectral regions in urine were found to be significantly associated with baseline lung function. These regions correspond to the metabolites trigonelline, hippurate and formate. Concentrations of each metabolite, standardized to urinary creatinine, were associated with baseline lung function (minimum p-value = 0.0002 for trigonelline). No significant associations were found with plasma metabolites. Two of the three urinary metabolites positively associated with baseline lung function, i.e. hippurate and formate, are often related to gut microflora. This suggests that the microbiome composition is variable between individuals with different lung function. Alternatively, the nature and origins of all three associated metabolites may reflect lifestyle differences affecting overall health. Our results will require replication and validation, but demonstrate the utility of NMR metabolomics as a screening tool for identifying novel biomarkers of lung disease or disease risk.

  8. Kathryn Clay, Ph.D. Vice President of Policy Strategy American...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Remarks of Kathryn Clay, Ph.D. Vice President of Policy Strategy American Gas Association PUBLIC MEETING ON ENERGY INFRASTRUCTURE SITING DEPARTMENT OF ENERGY QUADRENNIAL ENERGY ...

  9. American Venture Acceleration Fund

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    March 3, 2015 Nearly $700,000 in new revenue generated last two years LOS ALAMOS, N.M., March 3, 2015-Six Northern New Mexico Native American- owned and operated businesses received a total of $60,000 in grants through a Native American Venture Acceleration Fund created by Los Alamos National Security, LLC (LANS) and the Regional Development Corporation. The grants are designed to help the recipients create jobs, increase their revenue base and help diversify the area economy. "Our Native

  10. American Agri diesel LLC | Open Energy Information

    Open Energy Info (EERE)

    American Agri diesel LLC Jump to: navigation, search Name: American Agri-diesel LLC Place: Colorado Springs, Colorado Product: Biodiesel producer in Colorado. References: American...

  11. Lienert named American Welding Society Fellow

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Lienert Named American Welding Society Fellow Lienert named American Welding Society Fellow Lienert was inducted into the American Welding Society's 2012 Class of Fellows during...

  12. American Ag Fuels LLC | Open Energy Information

    Open Energy Info (EERE)

    American Ag Fuels LLC Jump to: navigation, search Name: American Ag Fuels LLC Place: Defiance, Ohio Zip: 43512 Product: Biodiesel producer in Defiance, Ohio. References: American...

  13. Building an American Economy to Last: American Competiveness in

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Manufacturing | Department of Energy an American Economy to Last: American Competiveness in Manufacturing Building an American Economy to Last: American Competiveness in Manufacturing August 16, 2012 - 9:20am Addthis Saving Energy and Resources 1 of 4 Saving Energy and Resources Thanks to additive manufacturing technology, Oak Ridge National Laboratory was able to fabricate a robotic hand with less energy use and material waste. The novel, lightweight, low-cost fluid powered hand was

  14. American Disabilities Act

    Broader source: Energy.gov [DOE]

    The Americans with Disabilities Act prohibits private employers, state and local governments, employment agencies and labor unions from discriminating against qualified individuals with disabilities in job application procedures, hiring, firing, advancement, compensation, job training, and other terms, conditions, and privileges of employment.

  15. American Recovery and Reinvestment Act

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    American Recovery and Reinvestment Act American Recovery and Reinvestment Act LANL was able to accelerate demolition and cleanup thanks to a $212 million award from the American Recovery and Reinvestment Act. August 1, 2013 Excavation trench and enclosure at TA-21. To protect air quality, MDA B is excavated under a dome. By September 2011, all projects were complete. In 2010 and 2011, LANL received $212 million in funding from the American Recovery and Reinvestment Act to complete three

  16. Buy American | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Buy American Buy American * What is the Buy American Act? * Buy America requirements for lighting components for projects funded by the Recovery Act * Does Buy America apply to ARRA grants to investor-owned utility companies? * Applicability of the Recovery Act Buy American provisions to rebates provided to homeowners * How flexible is the "unreasonable cost" exception in subpart 25.603? * Can a subrecipient seek a nonavailability waiver based on substandard energy efficiency of a U.S.

  17. North American Electric Reliability Corporation Interconnections...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Interconnections North American Electric Reliability Corporation Interconnections Map of the North American Electric Reliability Corporation Interconnection showing the Eastern, ...

  18. The American Recovery

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    American Recovery and Reinvestment Act Smart Grid Highlights Jumpstarting a Modern Grid October 2014 2 The Office of Electricity Delivery and Energy Reliability (OE) provides national leadership to ensure that the nation's energy delivery system is secure, resilient, and reliable. OE works to develop new technologies to improve the infrastructure that brings electricity into our homes, offices, and factories in partnership with industry, other federal agencies, and state and local governments.

  19. Overview of North American Hydrogen Sensor Standards

    SciTech Connect (OSTI)

    O'Malley, Kathleen; Lopez, Hugo; Cairns, Julie; Wichert, Richard; Rivkin, Carl; Burgess, Robert; Buttner, William

    2015-08-11

    An overview of the main North American codes and standards associated with hydrogen safety sensors is provided. The distinction between a code and a standard is defined, and the relationship between standards and codes is clarified, especially for those circumstances where a standard or a certification requirement is explicitly referenced within a code. The report identifies three main types of standards commonly applied to hydrogen sensors (interface and controls standards, shock and hazard standards, and performance-based standards). The certification process and a list and description of the main standards and model codes associated with the use of hydrogen safety sensors in hydrogen infrastructure are presented.

  20. Buy American Program Guidance | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Buy American Program Guidance Buy American Program Guidance Provides information on the December 17, 2009, Buy American Guidance eere_program_guidance_buy_american_121709.pdf (122 KB) More Documents & Publications Projects Funded by the American Recovery and Reinvestment Act of 2009 and Administered by the Office of Energy Efficiency and Renewable Energy (EERE) Notice Buy American Guidance Documents FAQs Docs for the Buy American Provision

  1. Iron supplementation at high altitudes induces inflammation and oxidative injury to lung tissues in rats

    SciTech Connect (OSTI)

    Salama, Samir A.; Omar, Hany A.; Maghrabi, Ibrahim A.; AlSaeed, Mohammed S.; EL-Tarras, Adel E.

    2014-01-01

    Exposure to high altitudes is associated with hypoxia and increased vulnerability to oxidative stress. Polycythemia (increased number of circulating erythrocytes) develops to compensate the high altitude associated hypoxia. Iron supplementation is, thus, recommended to meet the demand for the physiological polycythemia. Iron is a major player in redox reactions and may exacerbate the high altitudes-associated oxidative stress. The aim of this study was to explore the potential iron-induced oxidative lung tissue injury in rats at high altitudes (6000 ft above the sea level). Iron supplementation (2 mg elemental iron/kg, once daily for 15 days) induced histopathological changes to lung tissues that include severe congestion, dilatation of the blood vessels, emphysema in the air alveoli, and peribronchial inflammatory cell infiltration. The levels of pro-inflammatory cytokines (IL-1?, IL-6, and TNF-?), lipid peroxidation product and protein carbonyl content in lung tissues were significantly elevated. Moreover, the levels of reduced glutathione and total antioxidant capacity were significantly reduced. Co-administration of trolox, a water soluble vitamin E analog (25 mg/kg, once daily for the last 7 days of iron supplementation), alleviated the lung histological impairments, significantly decreased the pro-inflammatory cytokines, and restored the oxidative stress markers. Together, our findings indicate that iron supplementation at high altitudes induces lung tissue injury in rats. This injury could be mediated through excessive production of reactive oxygen species and induction of inflammatory responses. The study highlights the tissue injury induced by iron supplementation at high altitudes and suggests the co-administration of antioxidants such as trolox as protective measures. - Highlights: Iron supplementation at high altitudes induced lung histological changes in rats. Iron induced oxidative stress in lung tissues of rats at high altitudes. Iron increased

  2. Central American resource studies

    SciTech Connect (OSTI)

    Van Eeckhout, E.; Laughlin, A.W.

    1989-01-01

    Los Alamos National Laboratory has been working with five Central American countries to assist in the development of their energy and mineral resources. Since 1985, mineral resources in Costa Rica, peat resources in Costa Rica and Panama, geothermal energy resources in Honduras and Guatemala, and geothermal field development in El Salvador and Costa Rica have been topics of study. This paper presents an overview of this work -- within these proceedings are papers that deal with specific aspects of each topic, and these will be duly noted. 15 refs., 4 figs.

  3. American Physical Society

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    American Fuel Cell Bus Project Evaluation: Second Report Leslie Eudy and Matthew Post National Renewable Energy Laboratory Technical Report NREL/TP-5400-64344 September 2015 NREL is a national laboratory of the U.S. Department of Energy Office of Energy Efficiency & Renewable Energy Operated by the Alliance for Sustainable Energy, LLC This report is available at no cost from the National Renewable Energy Laboratory (NREL) at www.nrel.gov/publications. Contract No. DE-AC36-08GO28308 National

  4. American Elements | Open Energy Information

    Open Energy Info (EERE)

    Elements Jump to: navigation, search Name: American Elements Place: Los Angeles, California Zip: 90024 Product: US-based manufacturer and supplier of PV feedstocks such as silicon,...

  5. Native American Leadership Forum- East

    Broader source: Energy.gov [DOE]

    The Native American Leadership Forum - East is a hands-on training to provide opportunities to practice and master leadership and management communications for tribal and organizational success.

  6. New American Home 2009 (Brochure)

    SciTech Connect (OSTI)

    Not Available

    2008-12-01

    This brochure details the New American Home 2009, which demonstrates the use of innovative building materials, cutting-edge design, and the latest construction techniques.

  7. american museum of science and energy | National Nuclear Security

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Administration american museum of science and energy Smithsonian Associates Study Tour visits Y-12 The Smithsonian Associates Study Tour. This year marks the second year that the Smithsonian Institution has featured an Oak Ridge tour for its annual Associates Study Tour. Forty-three teachers and two tour leaders traveled from Washington to Oak Ridge for the three-day workshop packed with history

  8. South American oil

    SciTech Connect (OSTI)

    Not Available

    1992-06-01

    GAO reviewed the petroleum industries of the following eight South American Countries that produce petroleum but are not major exporters: Argentina, Bolivia, Brazil, Chile, Colombia, Ecuador, Peru, and Trinidad and Tobago. This report discusses the amount of crude oil the United States imports from the eight countries, expected crude oil production for these countries through the year 2010, and investment reforms that these countries have recently made in their petroleum industries. In general, although the United States imports some oil from these countries, as a group, the eight countries are currently net oil importers because combined domestic oil consumption exceeds oil production. Furthermore, the net oil imports are expected to continue to increase through the year 2010, making it unlikely that the United States will obtain increased oil shipments from these countries.

  9. American Transmission Systems Inc | Open Energy Information

    Open Energy Info (EERE)

    American Transmission Systems Inc Jump to: navigation, search Name: American Transmission Systems Inc Place: Ohio Website: www.atcllc.com Twitter: @amertransco References: EIA...

  10. American Electric Vehicles Inc | Open Energy Information

    Open Energy Info (EERE)

    Vehicles Inc Jump to: navigation, search Name: American Electric Vehicles Inc Place: Palmer Lake, Colorado Zip: 80133 Sector: Vehicles Product: American Electric Vehicles (AEV)...

  11. Lienert named American Welding Society Fellow

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Lienert named American Welding Society Fellow November 29, 2012 Thomas J. Lienert of the Lab's Metallurgy group was inducted into the American Welding Society's 2012 Class of...

  12. American Electric Technologies Inc | Open Energy Information

    Open Energy Info (EERE)

    Technologies Inc Jump to: navigation, search Name: American Electric Technologies Inc Place: Houston, Texas Zip: TX 77087 Sector: Services Product: American Electric Technologies...

  13. Energy Innovation: Green Button Initiative Empowering Americans...

    Office of Environmental Management (EM)

    Innovation: Green Button Initiative Empowering Americans to Save Energy and Money Energy Innovation: Green Button Initiative Empowering Americans to Save Energy and Money February ...

  14. President Obama's Commitment to American Energy | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    President Obama's Commitment to American Energy President Obama's Commitment to American Energy Addthis Speakers President Barack Obama Duration 4:38 Topic Energy Sector Jobs ...

  15. American Way Solar AWS | Open Energy Information

    Open Energy Info (EERE)

    navigation, search Name: American Way Solar (AWS) Place: Plzen, Czech Republic Sector: Solar Product: Czech subsidiary of US PV panel manufacturer, American Way Solar (AWS)....

  16. American Wind Capital | Open Energy Information

    Open Energy Info (EERE)

    Capital Jump to: navigation, search Name: American Wind Capital Place: Essex, Connecticut Zip: 64260 Sector: Wind energy Product: Connecticut-based American Wind Capital buys wind...

  17. American Capital Energy | Open Energy Information

    Open Energy Info (EERE)

    Energy Jump to: navigation, search Logo: American Capital Energy Name: American Capital Energy Address: 15 Tyngsboro Rd. Suite 4A Place: North Chelmsford, Massachusetts Zip: 01863...

  18. American Veterans Hiring Event | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    American Veterans Hiring Event American Veterans Hiring Event May 18, 2016 10:00AM to 2:20PM EDT AMVETS, Takoma, WA Contact Ed Agodoa

  19. American Solar Energy | Open Energy Information

    Open Energy Info (EERE)

    American Solar Energy Name: American Solar Energy Address: 11497 Columbia Drive West, Suite 10 Place: Jacksonville, Florida Zip: 32258 Sector: Solar Product: solar energy systems...

  20. American Alternative Energy Systems | Open Energy Information

    Open Energy Info (EERE)

    Alternative Energy Systems Jump to: navigation, search Name: American Alternative Energy Systems Place: Denton, Texas Zip: 76209 Product: An American company involved in project...

  1. North American Electric Reliability Corporation Interconnections...

    Broader source: Energy.gov (indexed) [DOE]

    Map of the North American Electric Reliability Corporation Interconnection showing the Eastern, Western, and Teaxs Interconnectins. North American Electric Reliability Corporation...

  2. American Renewable Energy | Open Energy Information

    Open Energy Info (EERE)

    Energy Jump to: navigation, search Name: American Renewable Energy Place: Evanston, Illinois Zip: 60202 Sector: Geothermal energy, Renewable Energy, Solar Product: American...

  3. American Clean Coal Fuels | Open Energy Information

    Open Energy Info (EERE)

    American Clean Coal Fuels Retrieved from "http:en.openei.orgwindex.php?titleAmericanCleanCoalFuels&oldid768408" Categories: Organizations Energy Generation Organizations...

  4. Energy Innovation: Green Button Initiative Empowering Americans...

    Energy Savers [EERE]

    Energy Innovation: Green Button Initiative Empowering Americans to Save Energy and Money Energy Innovation: Green Button Initiative Empowering Americans to Save Energy and Money...

  5. NORTH AMERICAN ELECTRIC RELIABILITY COUNCIL: Preliminary Disturbance...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    NORTH AMERICAN ELECTRIC RELIABILITY COUNCIL: Preliminary Disturbance Report (40.43 KB) More Documents & Publications North American Electric Reliability Council Power Outage Update ...

  6. Four Snapshots of American Energy Use

    Broader source: Energy.gov [DOE]

    Americans used more energy in 2013 than they did in 2012, including more renewable, nuclear and fossil energy. Learn other facts about American energy use trends.

  7. American Solar Energy Society | Open Energy Information

    Open Energy Info (EERE)

    American Solar Energy Society Name: American Solar Energy Society Address: 2400 Central Ave Place: Boulder, Colorado Zip: 80301 Region: Rockies Area Website: www.ases.org...

  8. Moore named an American Statistical Society Fellow

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Moore named an American Statistical Society Fellow Moore named an American Statistical Society Fellow The ASA inducted Leslie (Lisa) Moore as a Fellow at the 2014 Joint Statistical...

  9. Thomas selected as American Chemical Society Fellow

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Thomas selected as ACS Fellow Thomas selected as American Chemical Society Fellow Kimberly ... first Los Alamos researcher to be named a Fellow of the American Chemical Society (ACS). ...

  10. Comments of North American Electric Reliability Corporation ...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    North American Electric Reliability Corporation (NERC) to DOE Smart Grid RFI: Addressing Policy and Logistical Challenges Comments of North American Electric Reliability Corporation ...

  11. North American Electric Reliability Corporation (NERC): Reliability...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Integration of Smart Grid North American Electric Reliability Corporation (NERC): Reliability Considerations from the Integration of Smart Grid North American Electric ...

  12. North American Electric Reliability Corporation (NERC): Ensuring...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    North American Electric Reliability Corporation (NERC): Ensuring a Reliable Bulk Electric System North American Electric Reliability Corporation (NERC): Ensuring a Reliable Bulk ...

  13. Cars af Tomorrow and the American Community

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cars of Tomorrow and the American Community High School Curriculum Created by Northeast Sustainable Energy Association (NESEA) Click on the links below to take you to the Chapter heading: Cover Page and Orientation Availability and Distribution of Alternative Fuels Health, Pollution, and Safety Operation, Maintenance, and Refueling Fuel Fact Sheets H I G H S C H O O L C U R R I C U L U M O N A L T E R N A T I V E F U E L S 50 Miles Street, Suite 3, Greenfield, MA 01301 www.nesea.org June, 2002

  14. American Samoa Energy Action Plan

    SciTech Connect (OSTI)

    Haase, Scott; Esterly, Sean; Herdrich, David; Bodell, Tim; Visser, Charles

    2013-08-01

    Describes the five near-term strategies selected by the American Samoa Renewable Energy Committee (ASREC) during action planning workshops conducted in May 2013, and outlines the actions being taken to implement those strategies. Each option is tied to a priority identified in the earlier draft American Samoa Strategic Energy Plan as being an essential component of reducing American Samoa'spetroleum energy consumption. The actions described for each strategy provide a roadmap to facilitate the implementation of each strategy. This document is intended to evolve along with the advancement of the projects, and will be updated to reflect progress.

  15. Real-Time Tumor Tracking in the Lung Using an Electromagnetic Tracking System

    SciTech Connect (OSTI)

    Shah, Amish P.; Kupelian, Patrick A.; Waghorn, Benjamin J.; Willoughby, Twyla R.; Rineer, Justin M.; Maon, Rafael R.; Vollenweider, Mark A.; Meeks, Sanford L.

    2013-07-01

    Purpose: To describe the first use of the commercially available Calypso 4D Localization System in the lung. Methods and Materials: Under an institutional review board-approved protocol and an investigational device exemption from the US Food and Drug Administration, the Calypso system was used with nonclinical methods to acquire real-time 4-dimensional lung tumor tracks for 7 lung cancer patients. The aims of the study were to investigate (1) the potential for bronchoscopic implantation; (2) the stability of smooth-surface beacon transponders (transponders) after implantation; and (3) the ability to acquire tracking information within the lung. Electromagnetic tracking was not used for any clinical decision making and could only be performed before any radiation delivery in a research setting. All motion tracks for each patient were reviewed, and values of the average displacement, amplitude of motion, period, and associated correlation to a sinusoidal model (R{sup 2}) were tabulated for all 42 tracks. Results: For all 7 patients at least 1 transponder was successfully implanted. To assist in securing the transponder at the tumor site, it was necessary to implant a secondary fiducial for most transponders owing to the transponder's smooth surface. For 3 patients, insertion into the lung proved difficult, with only 1 transponder remaining fixed during implantation. One patient developed a pneumothorax after implantation of the secondary fiducial. Once implanted, 13 of 14 transponders remained stable within the lung and were successfully tracked with the tracking system. Conclusions: Our initial experience with electromagnetic guidance within the lung demonstrates that transponder implantation and tracking is achievable though not clinically available. This research investigation proved that lung tumor motion exhibits large variations from fraction to fraction within a single patient and that improvements to both transponder and tracking system are still necessary

  16. Crisis in American mining

    SciTech Connect (OSTI)

    Not Available

    1984-05-01

    The crisis in American mining is discussed. The discussion focuses on the outlook for coal in the overall energy picture. Because of the Arab oil embargo of 1973, the Iranian disruption of 1979, and the tenfold increase in oil prices over the past decade, radical changes have taken place in energy supply and demand patterns. Two of the most important of these changes relate to investment. First, large investments have been made in energy-efficient plants, equipment, buildings, and vehicles. Their effect will restrain energy demand growth for the foreseeable future. Second, investments have been made in fuel-switching, from oil to coal and nuclear power. As a result the oil demand at the end of this century will be at approximately the same level as it is today. Natural gas demand is also likely to be flat. Coal demand, on the other hand, is expected to increase steadily over the long term. Recent conditions in the coal industry are reviewed, and a specific 10-year forecast is given.

  17. African-American Partner Program

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Afghanistan NNSA program strengthens national security from afar The Nuclear Smuggling Detection and Deterrence (NSDD) program is a key component of NNSA's core mission to reduce nuclear threats. The program, part of NNSA's Office of Defense Nuclear Nonproliferation, provides partners tools and training to deter, detect, and investigate smuggling of

    AAPP African-American Partner Program Graduate career research experiences for African-American students in STEM disciplines Contacts Tommy

  18. Working In Indian Country: Building Successful Business Relationships with American Indian Tribes

    Broader source: Energy.gov [DOE]

    Sponsored by Association on American Indian Affairs, this interactive one-day workshop is designed for federal, state, and local government officials and business leaders who need or are required to develop working relationships with Indian tribes and organizations.

  19. Working in Indian Country: Building Successful Business Relationships with American Indian Tribes Workshop

    Broader source: Energy.gov [DOE]

    Sponsored by the Association on American Indian Affairs, this one-day conference is for federal, state, and local government officials and business leaders who have a need to develop working relationships with tribes and organizations.

  20. Working in Indian Country: Building Successful Business Relationships with American Indian Tribes Workshop

    Broader source: Energy.gov [DOE]

    Sponsored by the Association on American Indian Affairs, this one-day conference is for federal, state, and local government officials and business leaders who have a need to develop working...

  1. Response of Human Lung Epithelial Cells to Engineered Nanoparticles...

    Office of Scientific and Technical Information (OSTI)

    Response of Human Lung Epithelial Cells to Engineered Nanoparticles. Citation Details In-Document Search Title: Response of Human Lung Epithelial Cells to Engineered Nanoparticles. ...

  2. Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor...

    Office of Scientific and Technical Information (OSTI)

    Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of ... Citation Details In-Document Search Title: Structures of Lung Cancer-Derived EGFR Mutants ...

  3. Role of reactive nitrogen species generated via inducible nitric oxide synthase in vesicant-induced lung injury, inflammation and altered lung functioning

    SciTech Connect (OSTI)

    Sunil, Vasanthi R.; Shen, Jianliang; Patel-Vayas, Kinal; Gow, Andrew J.; Laskin, Jeffrey D.; Laskin, Debra L.

    2012-05-15

    Pulmonary toxicity induced by sulfur mustard and related vesicants is associated with oxidative stress. In the present studies we analyzed the role of reactive nitrogen species (RNS) generated via inducible nitric oxide synthase (iNOS) in lung injury and inflammation induced by vesicants using 2-chloroethyl ethyl sulfide (CEES) as a model. C57Bl/6 (WT) and iNOS ?/? mice were sacrificed 3 days or 14 days following intratracheal administration of CEES (6 mg/kg) or control. CEES intoxication resulted in transient (3 days) increases in bronchoalveolar lavage (BAL) cell and protein content in WT, but not iNOS ?/? mice. This correlated with expression of Ym1, a marker of oxidative stress in alveolar macrophages and epithelial cells. In contrast, in iNOS ?/? mice, Ym1 was only observed 14 days post-exposure in enlarged alveolar macrophages, suggesting that they are alternatively activated. This is supported by findings that lung tumor necrosis factor and lipocalin Lcn2 expression, mediators involved in tissue repair were also upregulated at this time in iNOS ?/? mice. Conversely, CEES-induced increases in the proinflammatory genes, monocyte chemotactic protein-1 and cyclooxygenase-2, were abrogated in iNOS ?/? mice. In WT mice, CEES treatment also resulted in increases in total lung resistance and decreases in compliance in response to methacholine, effects blunted by loss of iNOS. These data demonstrate that RNS, generated via iNOS play a role in the pathogenic responses to CEES, augmenting oxidative stress and inflammation and suppressing tissue repair. Elucidating inflammatory mechanisms mediating vesicant-induced lung injury is key to the development of therapeutics to treat mustard poisoning. -- Highlights: ? Lung injury, inflammation and oxidative stress are induced by the model vesicant CEES ? RNS generated via iNOS are important in the CEES-induced pulmonary toxicity ? iNOS ?/? mice are protected from CEES-induced lung toxicity and altered lung functioning.

  4. Molecular Markers of Lung Cancer in MAYAK Workers

    SciTech Connect (OSTI)

    Steven A. Belinsky, PhD

    2007-02-15

    The molecular mechanisms that result in the elevated risk for lung cancer associated with exposure to radiation have not been well characterized. Workers from the MAYAK nuclear enterprise are an ideal cohort in which to study the molecular epidemiology of cancer associated with radiation exposure and to identify the genes targeted for inactivation that in turn affect individual risk for radiation-induced lung cancer. Epidemiology studies of the MAYAK cohort indicate a significantly higher frequency for adenocarcinoma and squamous cell carcinoma (SCC) in workers than in a control population and a strong correlation between these tumor types and plutonium exposure. Two hypotheses will be evaluated through the proposed studies. First, radiation exposure targets specific genes for inactivation by promoter methylation. This hypothesis is supported by our recent studies with the MAYAK population that demonstrated the targeting of the p16 gene for inactivation by promoter methylation in adenocarcinomas from workers (1). Second, genes inactivated in tumors can serve as biomarkers for lung cancer risk in a cancer-free population of workers exposed to plutonium. Support for this hypothesis is based on exciting preliminary results of our nested, case-control study of persons from the Colorado cohort. In that study, a panel of methylation markers for predicting lung cancer risk is being evaluated in sputum samples from incident lung cancer cases and controls. The first hypothesis will be tested by determining the prevalence for promoter hypermethylation of a panel of genes shown to play a critical role in the development of either adenocarcinoma and/or SCC associated with tobacco. Our initial studies on adenocarcinoma in MAYAK workers will be extended to evaluate methylation of the PAX5 {alpha}, PAX5 {beta}, H-cadherin, GATA5, and bone morphogenesis 3B (BMP3B) genes in the original sample set described under Preliminary studies. In addition, studies will be initiated in SCC

  5. Emerging Latin American air quality regulation

    SciTech Connect (OSTI)

    Hosmer, A.W.; Vitale, E.M.; Guerrero, C.R.; Solorzano-Vincent, L.

    1998-12-31

    Latin America is the most urbanized region in the developing world. In recent years, significant economic growth has resulted in population migration from rural areas to urban centers, as well as in a substantial rise in the standard of living within the Region. These changes have impacted the air quality of Latin American countries as increased numbers of industrial facilities and motor vehicles release pollutants into the air. With the advent of new free trade agreements such as MERCOSUR and NAFTA, economic activity and associated pollutant levels can only be expected to continue to expand in the future. In order to address growing air pollution problems, many Latin America countries including Argentina, Brazil, Chile, Columbia, Costa Rica, and Mexico have passed, or will soon pass, new legislation to develop and strengthen their environmental frameworks with respect to air quality. As a first step toward understanding the impacts that this increased environmental regulation will have, this paper will examine the regulatory systems in six Latin American countries with respect to ambient air quality and for each of these countries: review a short history of the air quality problems within the country; outline the legal and institutional framework including key laws and implementing institutions; summarize in brief the current status of the country in terms of program development and implementation; and identify projected future trends. In addition, the paper will briefly review the international treaties that have bearing on Latin American air quality. Finally, the paper will conclude by identifying and exploring emerging trends in individual countries and the region as a whole.

  6. Americans for Solar Power ASPv | Open Energy Information

    Open Energy Info (EERE)

    Americans for Solar Power ASPv Jump to: navigation, search Name: Americans for Solar Power (ASPv) Place: Tempe, Arizona Zip: 85282 Sector: Solar Product: Americans for Solar Power...

  7. EA-200-A American Electric Power Service Corporation | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    -A American Electric Power Service Corporation EA-200-A American Electric Power Service Corporation Order authorizing American Electric Power Service Corporation to export electric ...

  8. EA-200 American Electric Power Service Corporation | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    200 American Electric Power Service Corporation EA-200 American Electric Power Service Corporation Order authorizing American Electric Power Service Corporation to export electric ...

  9. EA-236-A American Electric Power Service Corporation | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    6-A American Electric Power Service Corporation EA-236-A American Electric Power Service Corporation Order authorizing American Electric Power Service Corporation to export ...

  10. Society of American Indian Government Employees Annual National Training Program

    Broader source: Energy.gov [DOE]

    Event includes plenary session, American Indian law classes, Native American youth workshops, cultural presentations, and a veterans program. Sponsored by the Society of American Indian Government...

  11. EIS-0468: American Centrifuge Plant in Piketon, OH | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    8: American Centrifuge Plant in Piketon, OH EIS-0468: American Centrifuge Plant in Piketon, OH May 20, 2011 EIS-0468: Final Environmental Impact Statement Proposed American...

  12. LOS ALAMOS, New Mexico, December 15, 2011-The American Association...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and understanding the biochemical and biophysical processes of algae and other energy plants. John Gordon, Chemistry Division, for distinguished contributions to chemistries...

  13. QER- Comment of American Wind Energy Association 2

    Broader source: Energy.gov [DOE]

    QER Task Force – Attached please find brief supplemental comments that AWEA would like to submit for your consideration as you continuing drafting the QER.

  14. QER- Comment of American Public Power Association 3

    Broader source: Energy.gov [DOE]

    Attached are APPA’s comments for the Second public QER meeting. I have tried to submit these before too, so please send me a confirmation e-mail. Thanks in advance for your consideration of my request.

  15. QER- Comment of American Public Power Association 4

    Office of Energy Efficiency and Renewable Energy (EERE)

    I am not sure these made the record for the QER either, so I am sending them again. Sorry for all the e-mail, but I want to make sure these documents make the record. Thanks, and please enjoy the rest of your Sunday.

  16. Fall 2006 Meeting of theAmerican Statistical Association

    U.S. Energy Information Administration (EIA) Indexed Site

    5 and 6, 2006 Washington, D.C. 1. The National Energy Modeling System: The Next Steps Forward, Susan H. Holte, Technical Assistant to the Administrator This presentation to the Committee provided a status report on EIA's effort to upgrade and enhance the National Energy Modeling System (NEMS). While NEMS has been continuously updated and revised over its 15-year life to maintain relevancy, the time is right to step back, reconsider parts of the model, and request additional resources in support

  17. American Wind Energy Association Offshore WINDPOWER Conference & Exhibition

    Broader source: Energy.gov [DOE]

    AWEA Offshore WINDPOWER 2014 Conference & Exhibition is the largest offshore wind energy event in North America. The conference and exhibition will be held at the Atlantic City Convention...

  18. OSTIblog Articles in the American Association for the Advancement...

    Office of Scientific and Technical Information (OSTI)

    Be sure to stop by OSTI's booth where you can ask questions and see how to get worldwide R&D results free and fast via single-point-of-access web portals, such as: Science ...

  19. American Gas Association Memorandum Summarizing Ex Parte Communication...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AGA Memorandum Summarizing Ex Parte Communication PDF icon Condensing Heating and Water Heating Equipment Workshop Agenda PDF icon October 9th Workshop Presentation - Melissa ...

  20. Home Energy Score Program Overview for the American Gas Association...

    Energy Savers [EERE]

    ... And then the last screen is our heating, cooling, and hot water systems. Here we can enter either the efficiency value -- the AFUE in the case of gas or propane or oil. If you ...

  1. OSTIblog Articles in the American Association for the Advancement...

    Office of Scientific and Technical Information (OSTI)

    web portals, such as: Science Accelerator (DOE resources) Science.gov(U.S. federal agency science information) WorldWideScience.org (global science information) OSTI offers web-b...

  2. Imaging of occupational and environmental lung diseases

    SciTech Connect (OSTI)

    Akira, M.

    2008-03-15

    The chest radiograph is the basic tool for identifying occupational and environmental lung diseases; however, its sensitivity and specificity for the diagnosis of occupational and environmental lung diseases are low. High-resolution CT is the optimal method of recognizing parenchymal abnormalities in occupational and environmental disease. With the exception of pleural plaques, the CT findings of occupational and environmental lung diseases are nonspecific. Therefore, correlation of imaging features with history of exposure, other clinical features, and sometimes pathology is needed for the diagnosis of pneumoconiosis.

  3. The New American Home 2011

    SciTech Connect (OSTI)

    2010-12-01

    The New American Home® is built annually as a showcase home for the International Builders’ Show® to demonstrate innovative technologies, construction techniques, products, and design trends for the homebuilding industry to use in any new or remodeled home.

  4. American Samoa Power Authority | Open Energy Information

    Open Energy Info (EERE)

    Samoa Power Authority Jump to: navigation, search Name: American Samoa Power Authority Place: American Samoa References: EIA Form EIA-861 Final Data File for 2010 - File1a1 EIA...

  5. American Range: Order (2014-CE-23006)

    Broader source: Energy.gov [DOE]

    DOE ordered American Range Corporation to pay a $8,000 civil penalty after finding American Range had failed to certify that certain models of cooking products comply with the applicable energy conservation standards.

  6. American Valve: Order (2010-CW-1411)

    Broader source: Energy.gov [DOE]

    DOE ordered American Valve, Inc. to pay a $5,000 civil penalty after finding American Valve had failed to certify that certain showerhead models comply with the applicable water conservation standards.

  7. QER- Comment of American Water

    Office of Energy Efficiency and Renewable Energy (EERE)

    Dear QER Team; Thank you for the opportunity to provide comments to the Quadrennial Energy Review Task Force to discuss the water and energy nexus, advances in water innovative technologies, and the impact of climate change on water issues. On behalf of American Water, I wish to submit the following White Papers which we have prepared on these critical issues: Innovations in Energy Use Sustainability and Resiliency Planning for Water Utilities One Water Water/Energy Correlation The Value of Water Challenges in the Water Industry: Climate Change Challenges in the Water Industry: Meeting Demand in the West Innovation Solutions Within the Water Industry: Desalination Innovation Solutions Within the Water Industry: Going Green Innovation Solutions Within the Water Industry: Water Reuse Bridging the Water Innovation Gap. Founded in 1886, American Water is the largest publicly traded U.S. water and wastewater utility company. With headquarters in Voorhees, NJ, the company employs approximately 6,600 dedicated professionals who provide drinking water, wastewater and other related services to an estimated 14 million people in more than 40 states. Please feel free to contact me if you have any questions or if there is any way American Water can be helpful to your mission. Respectfully Yours, Martin (See attached file: White Papers.pdf) Martin D. Kerckhoff Vice President and Divisional General Counsel Central Division American Water CONFIDENTIAL & PRIVILEGED COMMUNICATION This email and any attachments hereto constitute a legally confidential communication from the Legal Department of American Water. The information contained herein is subject to attorney-client privilege and is for the sole use of the intended original addressee. If you are not the intended original addressee, you are hereby notified that any reading, disclosure, copying, distribution, use, or taking of any action in reliance on the contents contained herein is strictly prohibited. If you have received this

  8. American Superconductor Corporation AMSC | Open Energy Information

    Open Energy Info (EERE)

    Superconductor Corporation AMSC Jump to: navigation, search Name: American Superconductor Corporation (AMSC) Place: Westborough, Massachusetts Zip: 15810 Sector: Wind energy...

  9. Clean Energy Manufacturing Initiative: Increasing American Competitive...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Manufacturing Initiative: Increasing American Competitiveness Through Innovation Clean ... Manufacturing Initiative (CEMI), a collaborative effort between the federal government, ...

  10. American Vanadium | Energy Systems Integration | NREL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    American Vanadium NREL researchers are collaborating with American Vanadium, an integrated energy storage company, to evaluate and demonstrate the first North American CellCube battery management system. Photo of the American Vanadium CellCube device in a laboratory in the Energy Systems Integration Facility Photo by Dennis Schroeder CellCubes can store megawatts of energy, providing an uninterrupted supply of power from solar and wind power stations, no matter the outdoor conditions. Work at

  11. North American Synchrophasor Initiative (NASPI) Program Information...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Synchrophasor Initiative (NASPI) Program Information North American Synchrophasor Initiative (NASPI) Program Information Summary of the Transmission Reliability program's North ...

  12. Predicting Pneumonitis Risk: A Dosimetric Alternative to Mean Lung Dose

    SciTech Connect (OSTI)

    Tucker, Susan L.; Mohan, Radhe; Liengsawangwong, Raweewan; Martel, Mary K.; Liao Zhongxing

    2013-02-01

    Purpose: To determine whether the association between mean lung dose (MLD) and risk of severe (grade {>=}3) radiation pneumonitis (RP) depends on the dose distribution pattern to normal lung among patients receiving 3-dimensional conformal radiation therapy for non-small-cell lung cancer. Methods and Materials: Three cohorts treated with different beam arrangements were identified. One cohort (2-field boost [2FB]) received 2 parallel-opposed (anteroposterior-posteroanterior) fields per fraction initially, followed by a sequential boost delivered using 2 oblique beams. The other 2 cohorts received 3 or 4 straight fields (3FS and 4FS, respectively), ie, all fields were irradiated every day. The incidence of severe RP was plotted against MLD in each cohort, and data were analyzed using the Lyman-Kutcher-Burman (LKB) model. Results: The incidence of grade {>=}3 RP rose more steeply as a function of MLD in the 2FB cohort (N=120) than in the 4FS cohort (N=138), with an intermediate slope for the 3FS group (N=99). The estimated volume parameter from the LKB model was n=0.41 (95% confidence interval, 0.15-1.0) and led to a significant improvement in fit (P=.05) compared to a fit with volume parameter fixed at n=1 (the MLD model). Unlike the MLD model, the LKB model with n=0.41 provided a consistent description of the risk of severe RP in all three cohorts (2FB, 3FS, 4FS) simultaneously. Conclusions: When predicting risk of grade {>=}3 RP, the mean lung dose does not adequately take into account the effects of high doses. Instead, the effective dose, computed from the LKB model using volume parameter n=0.41, may provide a better dosimetric parameter for predicting RP risk. If confirmed, these findings support the conclusion that for the same MLD, high doses to small lung volumes ('a lot to a little') are worse than low doses to large volumes ('a little to a lot').

  13. Competition and Reliability in North American Electricity Markets...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Electricity Markets Technical Workshop Competition and Reliability in North American Electricity Markets Technical Workshop Competition and Reliability in North American ...

  14. Announcing the American Indian Research and Education Initiative |

    Office of Environmental Management (EM)

    Annelise Plooster About Us Annelise Plooster - Special Assistant, Office of the Deputy Secretary Annelise Plooster is a special assistant in the Office of the Deputy Secretary. She has staffed the Deputy Secretary on official visits to over a dozen countries. Prior to this role, Annelise worked at the American Wind Energy Association in Washington, DC. In 2009, she served a year with AmeriCorps VISTA* working with at-risk youth in the criminal juvenile justice system. Annelise is a native Iowan,

  15. DOE - Office of Legacy Management -- American Machine and Foundry Co -

    Office of Legacy Management (LM)

    Alexandria - VA 06 Alexandria - VA 06 FUSRAP Considered Sites Site: American Machine and Foundry Co - Alexandria ( VA.06 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: 1101 N. Royal Street , Alexandria , Virginia VA.06-3 Evaluation Year: 1987 VA.06-1 Site Operations: Research/Development activities associated with fuel element fabrication. VA.06-1 Site Disposition: Eliminated - No Authority to perform remedial action -

  16. Transcription factor FOXA2-centered transcriptional regulation network in non-small cell lung cancer

    SciTech Connect (OSTI)

    Jang, Sang-Min; An, Joo-Hee; Kim, Chul-Hong; Kim, Jung-Woong Choi, Kyung-Hee

    2015-08-07

    Lung cancer is the leading cause of cancer-mediated death. Although various therapeutic approaches are used for lung cancer treatment, these mainly target the tumor suppressor p53 transcription factor, which is involved in apoptosis and cell cycle arrest. However, p53-targeted therapies have limited application in lung cancer, since p53 is found to be mutated in more than half of lung cancers. In this study, we propose tumor suppressor FOXA2 as an alternative target protein for therapies against lung cancer and reveal a possible FOXA2-centered transcriptional regulation network by identifying new target genes and binding partners of FOXA2 by using various screening techniques. The genes encoding Glu/Asp-rich carboxy-terminal domain 2 (CITED2), nuclear receptor subfamily 0, group B, member 2 (NR0B2), cell adhesion molecule 1 (CADM1) and BCL2-associated X protein (BAX) were identified as putative target genes of FOXA2. Additionally, the proteins including highly similar to heat shock protein HSP 90-beta (HSP90A), heat shock 70 kDa protein 1A variant (HSPA1A), histone deacetylase 1 (HDAC1) and HDAC3 were identified as novel interacting partners of FOXA2. Moreover, we showed that FOXA2-dependent promoter activation of BAX and p21 genes is significantly reduced via physical interactions between the identified binding partners and FOXA2. These results provide opportunities to understand the FOXA2-centered transcriptional regulation network and novel therapeutic targets to modulate this network in p53-deficient lung cancer. - Highlights: • Identification of new target genes of FOXA2. • Identifications of novel interaction proteins of FOXA2. • Construction of FOXA2-centered transcriptional regulatory network in non-small cell lung cancer.

  17. Linear dimensions and volumes of human lungs

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Hickman, David P.

    2012-03-30

    TOTAL LUNG Capacity is defined as “the inspiratory capacity plus the functional residual capacity; the volume of air contained in the lungs at the end of a maximal inspiration; also equals vital capacity plus residual volume” (from MediLexicon.com). Within the Results and Discussion section of their April 2012 Health Physics paper, Kramer et al. briefly noted that the lungs of their experimental subjects were “not fully inflated.” By definition and failure to obtain maximal inspiration, Kramer et. al. did not measure Total Lung Capacity (TLC). The TLC equation generated from this work will tend to underestimate TLC and does notmore » improve or update total lung capacity data provided by ICRP and others. Likewise, the five linear measurements performed by Kramer et. al. are only representative of the conditions of the measurement (i.e., not at-rest volume, but not fully inflated either). While there was significant work performed and the data are interesting, the data does not represent a maximal situation, a minimal situation, or an at-rest situation. Moreover, while interesting, the linear data generated by this study is limited by the conditions of the experiment and may not be fully comparative with other lung or inspiratory parameters, measures, or physical dimensions.« less

  18. Section 1605 Buy American Provision under ARRA | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    605 Buy American Provision under ARRA Section 1605 Buy American Provision under ARRA Additional information on the Buy American Provision under ARRA. Section 1605 Buy American Provision under ARRA (9.71 KB) More Documents & Publications Nationwide Limited Public Interest Waiver for LED and HVAC Units Questions and Answers for the Smart Grid Investment Grant Program: Buy American Buy American Guidance Documents

  19. Associate director for Physical and Life Sciences, Lawrence Livermore

    National Nuclear Security Administration (NNSA)

    National Laboratory | National Nuclear Security Administration | (NNSA) Associate director for Physical and Life Sciences, Lawrence Livermore National Laboratory William Goldstein William Goldstein American Association for the Advancement of Science (AAAS) Fellow William Goldstein has been awarded the distinction of American Association for the Advancement of Science (AAAS) Fellow. Election as a fellow is an honor bestowed upon AAAS members by their peers. Goldstein was elected for

  20. Radiation-induced lung injury

    SciTech Connect (OSTI)

    Rosiello, R.A.; Merrill, W.W. )

    1990-03-01

    The use of radiation therapy is limited by the occurrence of the potentially fatal clinical syndromes of radiation pneumonitis and fibrosis. Radiation pneumonitis usually becomes clinically apparent from 2 to 6 months after completion of radiation therapy. It is characterized by fever, cough, dyspnea, and alveolar infiltrates on chest roentgenogram and may be difficult to differentiate from infection or recurrent malignancy. The pathogenesis is uncertain, but appears to involve both direct lung tissue toxicity and an inflammatory response. The syndrome may resolve spontaneously or may progress to respiratory failure. Corticosteroids may be effective therapy if started early in the course of the disease. The time course for the development of radiation fibrosis is later than that for radiation pneumonitis. It is usually present by 1 year following irradiation, but may not become clinically apparent until 2 years after radiation therapy. It is characterized by the insidious onset of dyspnea on exertion. It most often is mild, but can progress to chronic respiratory failure. There is no known successful treatment for this condition. 51 references.

  1. Attenuation of acute nitrogen mustard-induced lung injury, inflammation and fibrogenesis by a nitric oxide synthase inhibitor

    SciTech Connect (OSTI)

    Malaviya, Rama; Venosa, Alessandro; Hall, LeRoy; Gow, Andrew J.; Sinko, Patrick J.; Laskin, Jeffrey D.; Laskin, Debra L.

    2012-12-15

    Nitrogen mustard (NM) is a toxic vesicant known to cause damage to the respiratory tract. Injury is associated with increased expression of inducible nitric oxide synthase (iNOS). In these studies we analyzed the effects of transient inhibition of iNOS using aminoguanidine (AG) on NM-induced pulmonary toxicity. Rats were treated intratracheally with 0.125 mg/kg NM or control. Bronchoalveolar lavage fluid (BAL) and lung tissue were collected 1 d28 d later and lung injury, oxidative stress and fibrosis assessed. NM exposure resulted in progressive histopathological changes in the lung including multifocal lesions, perivascular and peribronchial edema, inflammatory cell accumulation, alveolar fibrin deposition, bronchiolization of alveolar septal walls, and fibrosis. This was correlated with trichrome staining and expression of proliferating cell nuclear antigen (PCNA). Expression of heme oxygenase (HO)-1 and manganese superoxide dismutase (Mn-SOD) was also increased in the lung following NM exposure, along with levels of protein and inflammatory cells in BAL, consistent with oxidative stress and alveolar-epithelial injury. Both classically activated proinflammatory (iNOS{sup +} and cyclooxygenase-2{sup +}) and alternatively activated profibrotic (YM-1{sup +} and galectin-3{sup +}) macrophages appeared in the lung following NM administration; this was evident within 1 d, and persisted for 28 d. AG administration (50 mg/kg, 2 /day, 1 d3 d) abrogated NM-induced injury, oxidative stress and inflammation at 1 d and 3 d post exposure, with no effects at 7 d or 28 d. These findings indicate that nitric oxide generated via iNOS contributes to acute NM-induced lung toxicity, however, transient inhibition of iNOS is not sufficient to protect against pulmonary fibrosis. -- Highlights: ? Nitrogen mustard (NM) induces acute lung injury and fibrosis. ? Pulmonary toxicity is associated with increased expression of iNOS. ? Transient inhibition of iNOS attenuates acute lung injury

  2. North American Natural Gas Markets

    SciTech Connect (OSTI)

    Not Available

    1989-02-01

    This report summarizes die research by an Energy Modeling Forum working group on the evolution of the North American natural gas markets between now and 2010. The group's findings are based partly on the results of a set of economic models of the natural gas industry that were run for four scenarios representing significantly different conditions: two oil price scenarios (upper and lower), a smaller total US resource base (low US resource case), and increased potential gas demand for electric generation (high US demand case). Several issues, such as the direction of regulatory policy and the size of the gas resource base, were analyzed separately without the use of models.

  3. North American Natural Gas Markets

    SciTech Connect (OSTI)

    Not Available

    1988-12-01

    This report sunnnarizes the research by an Energy Modeling Forum working group on the evolution of the North American natural gas markets between now and 2010. The group's findings are based partly on the results of a set of economic models of the natural gas industry that were run for four scenarios representing significantly different conditions: two oil price scenarios (upper and lower), a smaller total US resource base (low US resource case), and increased potential gas demand for electric generation (high US demand case). Several issues, such as the direction of regulatory policy and the size of the gas resource base, were analyzed separately without the use of models.

  4. Lienert named American Welding Society Fellow

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Lienert Named American Welding Society Fellow Lienert named American Welding Society Fellow Lienert was inducted into the American Welding Society's 2012 Class of Fellows during the recent FABTECH meeting in Las Vegas, Nevada. November 29, 2012 Thomas J. Lienert Thomas J. Lienert Thomas J. Lienert has served the welding community and industry with great distinction as an individual who contributed significantly to the knowledge, science, and application of welding. Thomas J. Lienert of the Lab's

  5. Celebrating our work with Native American Students in STEM During National Native American Heritage Month

    Broader source: Energy.gov [DOE]

    Throughout November, we celebrate Native American Heritage Month as a country, honoring the first people who lived in the United States and the ways that American Indians and Alaska Natives enrich...

  6. American Energy Technologies Inc | Open Energy Information

    Open Energy Info (EERE)

    Technologies Inc Jump to: navigation, search Name: American Energy Technologies Inc Place: Wayne, New Jersey Zip: 74700 Product: New Jersey-based clean energy system designer and...

  7. Native American Concerns | Open Energy Information

    Open Energy Info (EERE)

    to: navigation, search Retrieved from "http:en.openei.orgwindex.php?titleNativeAmericanConcerns&oldid612161" Feedback Contact needs updating Image needs updating...

  8. American Distillation Inc | Open Energy Information

    Open Energy Info (EERE)

    Distillation Inc Jump to: navigation, search Name: American Distillation Inc. Place: Leland, North Carolina Zip: 28451 Product: Biodiesel producer in North Carolina. References:...

  9. American Solar Electric Inc | Open Energy Information

    Open Energy Info (EERE)

    Electric Inc Jump to: navigation, search Name: American Solar Electric Inc Place: Scottsdale, Arizona Zip: 85251 Product: US installer of residential, commercial and industrial PV...

  10. American Energy Systems Inc | Open Energy Information

    Open Energy Info (EERE)

    Systems Inc Jump to: navigation, search Name: American Energy Systems Inc Place: Minnesota Zip: 55350 Product: Biofuel burning appliance manufacturer (pellets & corn). References:...

  11. American Process Inc | Open Energy Information

    Open Energy Info (EERE)

    Process Inc Jump to: navigation, search Name: American Process Inc Place: Atlanta, Georgia Zip: 30309 Product: Consulting engineering specialist firm dedicated to energy cost...

  12. American Renewable Fuels | Open Energy Information

    Open Energy Info (EERE)

    Fuels Jump to: navigation, search Name: American Renewable Fuels Place: Dallas, Texas Zip: TX 75201 Sector: Renewable Energy Product: Developer of commercial scale renewable fuels...

  13. Native American companies receive economic development grants

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Native American VAF Community Connections: Your link to news and opportunities from Los Alamos National Laboratory Latest Issue: Dec. 2015-Jan. 2016 all issues All Issues submit...

  14. North American Hydro | Open Energy Information

    Open Energy Info (EERE)

    Hydro Jump to: navigation, search Name: North American Hydro Place: Schofield, Wisconsin Zip: 54476 Sector: Hydro Product: Focused on developing, upgrading, owning, and operating...

  15. American Municipal Power | Open Energy Information

    Open Energy Info (EERE)

    Municipal Power Jump to: navigation, search Name: American Municipal Power Place: Columbus, Ohio Zip: 43219 Product: AMP is a non-profit corporation that owns and operates electric...

  16. AMREL American Reliance ARI | Open Energy Information

    Open Energy Info (EERE)

    AMREL American Reliance ARI Jump to: navigation, search Name: AMRELAmerican Reliance (ARI) Place: El Monte, California Zip: 91731 Product: Manufacturer of programmable power...

  17. American Renewables LLC | Open Energy Information

    Open Energy Info (EERE)

    Renewables LLC Jump to: navigation, search Name: American Renewables LLC Place: Boston, Massachusetts Sector: Biomass Product: US developer of biomass-fueled power generating...

  18. North American Coating Laboratories | Open Energy Information

    Open Energy Info (EERE)

    Coating Laboratories Jump to: navigation, search Name: North American Coating Laboratories Address: 9450 Pineneedle Drive Place: Mentor, Ohio Zip: 44060 Sector: Services, Solar...

  19. North American Biofuels | Open Energy Information

    Open Energy Info (EERE)

    Biofuels Jump to: navigation, search Name: North American Biofuels Place: Bohemia, New York Product: Biodiesel eqwuipment manufacturer and producer of biodiesel Coordinates:...

  20. New American Home 2011, Orlando, Florida (Brochure)

    SciTech Connect (OSTI)

    Not Available

    2010-12-01

    This brochure details the New American Home 2011, which demonstrates the use of innovative building materials, cutting-edge design, and the latest construction techniques.

  1. American Capital Energy Inc | Open Energy Information

    Open Energy Info (EERE)

    Capital Energy Inc Jump to: navigation, search Name: American Capital Energy Inc Place: North Chelmsford, Massachusetts Zip: 1863 Sector: Services Product: Full-service PV...

  2. American Fusion News | Princeton Plasma Physics Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    American Fusion News General Atomics (GA) December 4, 2012 The Scorpion's Strategy: "Catch and Subdue" December 4, 2012 Frozen Bullets Tame Unruly Edge Plasmas in Fusion Experiment ...

  3. Sandia Energy - North American Electric Reliability Corporation...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    North American Electric Reliability Corporation (NERC) Report Posted Home Energy Assurance Infrastructure Security Grid Integration News News & Events Transmission Grid Integration...

  4. U.S. Department of Energy American ...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    In 1998, at the request of and in consultation with Indian Nations, DOE revised the Policy to effect greater and comprehensive implementation. A revised American Indian and Alaska ...

  5. American Range: Proposed Penalty (2014-CE-23006)

    Broader source: Energy.gov [DOE]

    DOE alleged in a Notice of Proposed Civil Penalty that American Range Corporation failed to certify cooking products as compliant with the applicable energy conservation standards.

  6. American Battery Charging Inc | Open Energy Information

    Open Energy Info (EERE)

    Battery Charging Inc Jump to: navigation, search Name: American Battery Charging Inc Place: Smithfield, Rhode Island Zip: 2917 Product: Manufacturer of industrial and railroad...

  7. North American Biodiesel | Open Energy Information

    Open Energy Info (EERE)

    North American Biodiesel Place: Menmonee Falls, Wisconsin Product: Biodiesel producer currently developing a biodiesel plant in Butler, Wisconsin and with plans to develop another...

  8. Asian American Pacific Islander Heritage Month

    Broader source: Energy.gov [DOE]

    Generations of Asian Americans and Pacific Islanders (AAPIs) have helped make America what it is today. Their histories recall bitter hardships and proud accomplishments -- from the laborers who...

  9. Americans with Disabilities Act Signed (1990)

    Broader source: Energy.gov [DOE]

    The Americans with Disabilities Act of 1990 (ADA) prohibits discrimination and ensures equal opportunity for persons with disabilities in employment, State and local government services, public...

  10. American Lithium Energy Corp | Open Energy Information

    Open Energy Info (EERE)

    Lithium Energy Corp Jump to: navigation, search Name: American Lithium Energy Corp Place: San Marcos, California Zip: 92069 Product: California-based developer of lithium ion...

  11. 2005 American Conference on Theoretical Chemistry

    SciTech Connect (OSTI)

    Carter, Emily A

    2006-11-19

    The materials uploaded are meant to serve as final report on the funds provided by DOE-BES to help sponsor the 2005 American Conference on Theoretical Chemistry.

  12. American Wind Manufacturing | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    American Wind Manufacturing Addthis 1 of 9 Nordex USA -- a global manufacturer of wind turbines -- delivered and installed turbine components for the Power County Wind...

  13. 2014 American Energy & Manufacturing Competitiveness Summit in...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Summit. Image: John Harrington, Council on Competitiveness 6 of 10 Local Motors CEO Jay Rogers demonstrates the 3D-printed car during the American Energy & Manufacturing...

  14. American Valve: Proposed Penalty (2010-CW-1411)

    Broader source: Energy.gov [DOE]

    DOE alleged in a Notice of Proposed Civil Penalty that American Valve, Inc. failed to certify a variety of showerheads as compliant with the applicable water conservation standards.

  15. American Hydrogen Corporation | Open Energy Information

    Open Energy Info (EERE)

    Hydrogen Corporation Jump to: navigation, search Name: American Hydrogen Corporation Address: OU Innovation Center, 340 W State St. Unit 40 Place: Athens, Ohio Zip: 45701 Sector:...

  16. Weatherization Formula Grants - American Recovery and Reinvestment...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    More Documents & Publications Microsoft Word - nDE-FOA-0000051.rtf Weatherization Formula Grants - American Recovery and Reinvestment Act (ARRA) WPN 10-9: Amendment to ...

  17. 2015 American Energy and Manufacturing Competitiveness Summit

    Office of Energy Efficiency and Renewable Energy (EERE)

    The 2015 American Energy & Manufacturing Competitiveness (AEMC) Summit is a gathering of preeminent leaders from industry, academia, labor, the national laboratories, government and media to:

  18. American Energy and Manufacturing Competitiveness Summit

    Office of Energy Efficiency and Renewable Energy (EERE)

    The American Energy and Manufacturing Competitiveness Summit will bring together leaders and perspectives from industry, government, academia, national laboratories, labor, and policy organizations...

  19. Frequency Instability Problems in North American Interconnections

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Instability Problems in North American Interconnections Prepared by: Energy Sector Planning and Analysis (ESPA) ... would make the situation worse during an emergency event. ...

  20. Analysis of lung tumor initiation and progression in transgenic mice for Cre-inducible overexpression of Cul4A gene

    SciTech Connect (OSTI)

    Wang, Yang; Xu, Zhidong; Mao, Jian -Hua; Hung, Ming -Szu; Hsieh, David; Au, Alfred; Jablons, David M.; You, Liang

    2015-06-08

    Background: Lung cancer is the leading cause of morbidity and death worldwide. Although the available lung cancer animal models have been informative and further propel our understanding of human lung cancer, they still do not fully recapitulate the complexities of human lung cancer. The pathogenesis of lung cancer remains highly elusive because of its aggressive biologic nature and considerable heterogeneity, compared to other cancers. The association of Cul4A amplification with aggressive tumor growth and poor prognosis has been suggested. Our previous study suggested that Cul4A is oncogenic in vitro, but its oncogenic role in vivo has not been studied. Methods: Viral delivery approaches have been used extensively to model cancer in mouse models. In our experiments, we used Cre-recombinase induced overexpression of the Cul4A gene in transgenic mice to study the role of Cul4A on lung tumor initiation and progression and have developed a new model of lung tumor development in mice harboring a conditionally expressed allele of Cul4A. Results: Here we show that the use of a recombinant adenovirus expressing Cre-recombinase (“AdenoCre”) to induce Cul4A overexpression in the lungs of mice allows controls of the timing and multiplicity of tumor initiation. Following our mouse models, we are able to study the potential role of Cul4A in the development and progression in pulmonary adenocarcinoma as well. Conclusion: Our findings indicate that Cul4A is oncogenic in vivo, and this mouse model is a tool in understanding the mechanisms of Cul4A in human cancers and for testing experimental therapies targeting Cul4A.

  1. Analysis of lung tumor initiation and progression in transgenic mice for Cre-inducible overexpression of Cul4A gene

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Wang, Yang; Xu, Zhidong; Mao, Jian -Hua; Hung, Ming -Szu; Hsieh, David; Au, Alfred; Jablons, David M.; You, Liang

    2015-06-08

    Background: Lung cancer is the leading cause of morbidity and death worldwide. Although the available lung cancer animal models have been informative and further propel our understanding of human lung cancer, they still do not fully recapitulate the complexities of human lung cancer. The pathogenesis of lung cancer remains highly elusive because of its aggressive biologic nature and considerable heterogeneity, compared to other cancers. The association of Cul4A amplification with aggressive tumor growth and poor prognosis has been suggested. Our previous study suggested that Cul4A is oncogenic in vitro, but its oncogenic role in vivo has not been studied. Methods:more » Viral delivery approaches have been used extensively to model cancer in mouse models. In our experiments, we used Cre-recombinase induced overexpression of the Cul4A gene in transgenic mice to study the role of Cul4A on lung tumor initiation and progression and have developed a new model of lung tumor development in mice harboring a conditionally expressed allele of Cul4A. Results: Here we show that the use of a recombinant adenovirus expressing Cre-recombinase (“AdenoCre”) to induce Cul4A overexpression in the lungs of mice allows controls of the timing and multiplicity of tumor initiation. Following our mouse models, we are able to study the potential role of Cul4A in the development and progression in pulmonary adenocarcinoma as well. Conclusion: Our findings indicate that Cul4A is oncogenic in vivo, and this mouse model is a tool in understanding the mechanisms of Cul4A in human cancers and for testing experimental therapies targeting Cul4A.« less

  2. Fifth Annual Native American Housing Conference

    Broader source: Energy.gov [DOE]

    The Fifth Annual Native American Housing Conference will be held in conjunction with the Native American Economic Development Conference. Attendees will hear from top experts in the housing field on the state of housing in Native America and what programs are available to assist you in taking the next step.

  3. American Cooler Technologies: Order (2013-CE-5305)

    Broader source: Energy.gov [DOE]

    DOE ordered American Cooler Technologies to pay a $8,000 civil penalty after finding American Cooler Technologies had failed to certify that certain models of walk-in coolers or freezers (WICF) components comply with the applicable energy conservation standards.

  4. American Standard: Order (2013-CW-3001)

    Broader source: Energy.gov [DOE]

    DOE ordered AS America, Inc., d/b/a American Standard Brands to pay a $8,000 civil penalty after finding American Standard had failed to certify that certain models of water closets comply with the applicable water conservation standards.

  5. A Desk Guide to Buy American Provisions of the American Recovery and Reinvestment Act of 2009

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    a g e | 0 1 A Desk Guide to the Buy American Provisions of the Recovery Act- February 2011 2 A Desk Guide to the Buy American Provisions of the Recovery Act- February 2011 The US Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) Buy American team has prepared this desk guide for Award Recipients of EERE Recovery Act Awards to assist them in applying the Buy American provisions 1 of the American Recovery and Reinvestment Act of 2009 (Recovery Act) to EERE awards

  6. Effects of effluents of coal combustion and gasification upon lung structure and function. Annual report

    SciTech Connect (OSTI)

    Hinton, D.E.

    1980-01-01

    The overall objective of the proposed research is to correlate both structural and functional alterations in cells and tissues of the lung brought about by exposure to fluidized bed combustion and fixed bed gasification effluents and reagent grade oxides of metals known to be associated with coal combustion gasification. Projected milestones are described. Progress during the first year in setting up aerosol exposure facilities, intratracheal instillations, pulmonary mechanics, and morphometric examinations is reported. (DMC)

  7. Role of p53–fibrinolytic system cross-talk in the regulation of quartz-induced lung injury

    SciTech Connect (OSTI)

    Bhandary, Yashodhar P.; Shetty, Shwetha K.; Marudamuthu, Amarnath S.; Fu, Jian; Pinson, Barbara M.; Levin, Jeffrey; Shetty, Sreerama

    2015-03-01

    Silica is the major component of airborne dust generated by wind, manufacturing and/or demolition. Chronic occupational inhalation of silica dust containing crystalline quartz is by far the predominant form of silicosis in humans. Silicosis is a progressive lung disease that typically arises after a very long latency and is a major occupational concern with no known effective treatment. The mechanism of silicosis is not clearly understood. However, silicosis is associated with increased cell death, expression of redox enzymes and pro-fibrotic cytokines and chemokines. Since alveolar epithelial cell (AEC) death and disruption of alveolar fibrinolysis is often associated with both acute and chronic lung injuries, we explored whether p53-mediated changes in the urokinase-type plasminogen activator (uPA) system contributes to silica-induced lung injury. We further sought to determine whether caveolin-1 scaffolding domain peptide (CSP), which inhibits p53 expression, mitigates lung injury associated with exposure to silica. Lung tissues and AECs isolated from wild-type (WT) mice exposed to silica exhibit increased apoptosis, p53 and PAI-1, and suppression of uPA expression. Treatment of WT mice with CSP inhibits PAI-1, restores uPA expression and prevents AEC apoptosis by suppressing p53, which is otherwise induced in mice exposed to silica. The process involves CSP-mediated inhibition of serine-15 phosphorylation of p53 by inhibition of protein phosphatase 2A-C (PP2A-C) interaction with silica-induced caveolin-1 in AECs. These observations suggest that changes in the p53–uPA fibrinolytic system cross-talk contribute to lung injury caused by inhalation of silica dust containing crystalline quartz and is protected by CSP by targeting this pathway. - Highlights: • Chronic exposure to quartz dusts is a major cause of lung injury and silicosis. • The survival of patients with silicosis is bleak due to lack of effective treatments. • This study defines a new role of

  8. FAQs Docs for the Buy American Provision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    FAQs Docs for the Buy American Provision FAQs Docs for the Buy American Provision These documents answer the most frequently asked questions about the Buy American Provision. International Trade Agreements and the Recovery Act Buy American Provisions: Frequently Asked Questions (57.16 KB) Computer Hardware and Software: Frequently Asked Questions (50.6 KB) More Documents & Publications Questions and Answers for the Smart Grid Investment Grant Program: Buy American Buy American Guidance

  9. American Society of Mechanical Engineers/Savannah River National...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    American Society of Mechanical EngineersSavannah River National Laboratory (ASMESRNL) ... American Society of Mechanical EngineersSavannah River National Laboratory (ASMESRNL) ...

  10. Sino American Silicon Products Inc SAS | Open Energy Information

    Open Energy Info (EERE)

    Sino American Silicon Products Inc SAS Jump to: navigation, search Name: Sino-American Silicon Products Inc (SAS) Place: Hsinchu, Taiwan, Taiwan Product: Taiwan-based manufacturer...