Sample records for american lung association

  1. AmericanLungAssociationStateofLungDiseaseinDiverseCommunities2010 55 Lung Cancer

    E-Print Network [OSTI]

    Kaski, Samuel

    AmericanLungAssociationStateofLungDiseaseinDiverseCommunities2010 55 Lung Cancer Lung cancer is the uncontrolled growth of abnormal cells in one or both of the lungs . While normal cells reproduce and develop into healthy lung tissue, these abnormal cells reproduce faster and never grow into normal lung tissue . Lumps

  2. american lung association: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of Materials Research (DMR) and funding organizations in Africa, Asia and Europe. Funding organizations in t Massachusetts at Lowell, University of 10 American Economic...

  3. AMERICAN THORACIC SOCIETY PATIENT HEALTH SERIES Lung Cancer Prevention

    E-Print Network [OSTI]

    Kaski, Samuel

    AMERICAN THORACIC SOCIETY PATIENT HEALTH SERIES Lung Cancer Prevention What are the chances that I will develop lung cancer? The #1 cause of lung cancer is exposure to tobacco smoke. Your chances increase others (second-hand smoke), the greater your chances of developing lung cancer. People who have never

  4. Moore honored with American Statistical Association award

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    American Statistical Association Award Moore honored with American Statistical Association award Lisa Moore is the recipient of the 2013 Don Owen Award presented by the American...

  5. American Wind Energy Association Offshore WINDPOWER Conference...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    American Wind Energy Association Offshore WINDPOWER Conference & Exhibition American Wind Energy Association Offshore WINDPOWER Conference & Exhibition October 7, 2014 9:00AM EDT...

  6. Undifferentiated Connective Tissue Disease-Associated Interstitial Lung Disease: Changes in Lung Function

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    Lung (2010) 188:143–149 DOI 10.1007/s00408-009-Tissue Disease-Associated Interstitial Lung Disease:Changes in Lung Function Brent W. Kinder • Cyrus Shariat •

  7. AMERICAN STATISTICAL ASSOCIATION

    U.S. Energy Information Administration (EIA) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro IndustriesTownDells,1 U.S. Department of Energygasoline4Residential17.Keeping PaceAMERICAN

  8. American Statistical Association National Science Foundation

    E-Print Network [OSTI]

    Bermúdez, José Luis

    American Statistical Association National Science Foundation U.S. Census Bureau ASA American Statistical Association 732 North Washington Street Alexandria, VA 22314-1943 U.S. government and analysis, statistical methodology and computing, information and behavioral science, and geography

  9. Conditional deletion of epithelial IKKbeta impairs alveolar formation through apoptosis and decreased VEGF expression during early mouse lung morphogenesis

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    HL076538, V.L. ); American Lung Association of CA ResearchBL performed the lung morphometric and quantitativedouble transgenic animals and lung dissections. JX performed

  10. American Statistical Association Names Fellows for 2010 ALEXANDRIA VA (PRWEB) MAY 20, 2010 The American Statistical Association (ASA), the

    E-Print Network [OSTI]

    Ponce, V. Miguel

    American Statistical Association Names Fellows for 2010 ALEXANDRIA VA (PRWEB) MAY 20, 2010 ­ The American Statistical Association (ASA), the nation's preeminent professional statistical society, today the American Statistical Association The American Statistical Association (ASA), a scientific and educational

  11. AMERICAN JOURNAL OF INDUSTRIAL MEDICINE 49:709718 (2006) Smoking Imputation and Lung Cancer in

    E-Print Network [OSTI]

    Reid, Nancy

    2006-01-01T23:59:59.000Z

    AMERICAN JOURNAL OF INDUSTRIAL MEDICINE 49:709­718 (2006) Smoking Imputation and Lung Cancer exhaust exposure and lung cancer mortality in a large retrospective cohort study of US railroad workers­1996. Mortality analyses incorporated the effect of smoking on lung cancer risk. Results The smoking adjusted

  12. american statistical association: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    23 Grant Title: AMERICAN ASSOCIATION OF UNIVERSITY WOMEN (AAUW) -AMERICAN FELLOWSHIPS Funding Opportunity Number: NA Engineering Websites Summary: Grant Title: AMERICAN...

  13. American Wind Energy Association Wind Energy Finance and Investment...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    American Wind Energy Association Wind Energy Finance and Investment Seminar American Wind Energy Association Wind Energy Finance and Investment Seminar October 20, 2014 8:00AM EDT...

  14. Jump to first page American Planning Association

    E-Print Network [OSTI]

    to first page How Smart is your Community? Small group exercise 5. CENTRAL CITY VITALITY Examples: GradeJump to first page American Planning Association Core Smart Growth Principles 1) INCREASED CITIZEN, adaptive re-use) 5) CENTRAL CITY VITALITY 6) GREATER MIX OF USES AND HOUSING CHOICES FOCUSED AROUND HUMAN

  15. TruLifesaver American Heart Association Basic Life Support Course

    E-Print Network [OSTI]

    Gering, Jon C.

    TruLifesaver American Heart Association Basic Life Support Course The Truman Institute P: 660 concepts of high-quality CPR · The American Heart Association Chain of Survival · Differences between Cost includes all instruction, materials and two year certification with the American Heart Association

  16. Genome-wide association study of lung function phenotypes in a founder population

    E-Print Network [OSTI]

    Abney, Mark

    Genome-wide association study of lung function phenotypes in a founder population Tsung-Chieh Yao, Detroit, Mich, Baltimore, Md, Madison, Wis, and Taoyuan, Taiwan Background: Lung function is a long) associated with lung function. Methods: We performed a genome-wide association study (GWAS) of FEV1, forced

  17. american planning association: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Page Topic Index 1 Associate at the American Planning Association. Planning for Solar Energy CiteSeer Summary: There is a growing desire among communities to become more...

  18. Telomere Length in Circulating Leukocytes Is Associated with Lung Function and Disease

    E-Print Network [OSTI]

    Nyholt, Dale R.

    Telomere Length in Circulating Leukocytes Is Associated with Lung Function and Disease Eva Albrecht. Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Munich, Germany

  19. American Wind Energy Association Wind Energy Finance and Investment Seminar

    Broader source: Energy.gov [DOE]

    The American Wind Energy Association Wind Energy Finance and Investment Seminar will be attended by representatives in the financial sector, businesses, bankers, government and other nonprofit...

  20. Telomere length in circulating leukocytes is associated with lung function and

    E-Print Network [OSTI]

    Nyholt, Dale R.

    Telomere length in circulating leukocytes is associated with lung function and disease Eva Albrecht intrinsic age-related processes contribute to the interindividual variability of lung function. Our meta-analysis of 14 studies included 934 COPD cases with 15846 controls defined according to the Global Lungs

  1. Multi-walled carbon nanotube-induced gene expression in the mouse lung: Association with lung pathology

    SciTech Connect (OSTI)

    Pacurari, M. [Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506-9300 (United States); Qian, Y., E-mail: yaq2@cdc.gov [Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Porter, D.W.; Wolfarth, M. [Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Wan, Y.; Luo, D. [Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506-9300 (United States); Ding, M. [Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Castranova, V. [Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506-9300 (United States); Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Guo, N.L., E-mail: lguo@hsc.wvu.edu [Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506-9300 (United States); Department of Community Medicine, School of Medicine, West Virginia University, Morgantown, WV 26506-9190 (United States)

    2011-08-15T23:59:59.000Z

    Due to the fibrous shape and durability of multi-walled carbon nanotubes (MWCNT), concerns regarding their potential for producing environmental and human health risks, including carcinogenesis, have been raised. This study sought to investigate how previously identified lung cancer prognostic biomarkers and the related cancer signaling pathways are affected in the mouse lung following pharyngeal aspiration of well-dispersed MWCNT. A total of 63 identified lung cancer prognostic biomarker genes and major signaling biomarker genes were analyzed in mouse lungs (n = 80) exposed to 0, 10, 20, 40, or 80 {mu}g of MWCNT by pharyngeal aspiration at 7 and 56 days post-exposure using quantitative PCR assays. At 7 and 56 days post-exposure, a set of 7 genes and a set of 11 genes, respectively, showed differential expression in the lungs of mice exposed to MWCNT vs. the control group. Additionally, these significant genes could separate the control group from the treated group over the time series in a hierarchical gene clustering analysis. Furthermore, 4 genes from these two sets of significant genes, coiled-coil domain containing-99 (Ccdc99), muscle segment homeobox gene-2 (Msx2), nitric oxide synthase-2 (Nos2), and wingless-type inhibitory factor-1 (Wif1), showed significant mRNA expression perturbations at both time points. It was also found that the expression changes of these 4 overlapping genes at 7 days post-exposure were attenuated at 56 days post-exposure. Ingenuity Pathway Analysis (IPA) found that several carcinogenic-related signaling pathways and carcinogenesis itself were associated with both the 7 and 11 gene signatures. Taken together, this study identifies that MWCNT exposure affects a subset of lung cancer biomarkers in mouse lungs. - Research Highlights: > Multi-Walled Carbon Nanotubes affect lung cancer biomarkers in mouse lungs. > The results suggest potentially harmful effects of MWCNT exposure on human lungs. > The results could potentially be used for the medical surveillance of workers.

  2. QER- Comment of American Wind Energy Association 1

    Broader source: Energy.gov [DOE]

    Attached please find the comments of the American Wind Energy Association (AWEA) on the QER. Please don’t hesitate to contact me if you have any questions. Thank you. Tom

  3. Virtual Mentor American Medical Association Journal of Ethics

    E-Print Network [OSTI]

    Fujimura, Joan

    Virtual Mentor American Medical Association Journal of Ethics August 2012, Volume 14, Number 8: 657, such as a particular genetic variant that might be related www.virtualmentor.org Virtual Mentor, August 2012--Vol 14

  4. The respiratory health and lung function of Anglo-American children in a smelter town

    SciTech Connect (OSTI)

    Dodge, R.

    1983-02-01T23:59:59.000Z

    Cooper smelters are large, usually isolated, sources of air pollution. Arizona has several such plants on the periphery of small communities. The smelters emit predominantly sulfur oxides and particulates, and the residents of these communities intermittently are exposed to high concentrations (24-h sulfur dioxide (SO2) . 250 to 500 micrograms/m3) of smelter smoke but little other pollution. This study compared the respiratory health of Anglo-American school children who lived in one smelter community with children living in another small community in Arizona that was free of smelter air pollution. The prevalence of cough, as determined by questionnaire, was 25.6% in the smelter town children and 14.3% in the nonsmelter town children (p less than 0.05). Pulmonary function at the study onset was equal in the two groups. Over the course of the 4 yr of study, lung function growth (measured as actual forced expiratory volume in one second (FEV1) after 4 yr of study minus predicted FEV1) was also equal in the smelter town and nonsmelter town children. These results suggest that children in smelter communities have slightly more cough when compared with children living in other communities, but no differences in initial lung function or lung function at yearly testing over the period of the study.

  5. EV Community Readiness projects: American Lung Association of...

    Broader source: Energy.gov (indexed) [DOE]

    TN) - Promote PEVs and educate the public through a variety of events, such as the Better Living Show, community events and at the science museum. - Spread the word on PEV tourism...

  6. Didactic Program in Dietetics is accredited by the American Dietetic Association.

    E-Print Network [OSTI]

    Gallo, Linda C.

    330 Didactic Program in Dietetics is accredited by the American Dietetic Association. Faculty didactic program in foods and nutrition allows students eligibility for membership in the American Dietetic

  7. Didactic Program in Dietetics is accredited by the American Dietetic Association.

    E-Print Network [OSTI]

    Gallo, Linda C.

    337 Didactic Program in Dietetics is accredited by the American Dietetic Association. Faculty didactic program in foods and nutrition allows students eligibility for membership in the American Dietetic

  8. American Gas Association | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The Future of1Albuquerque, NM -Alicia MoultonPassEnergy InnovatorTurningAmerican

  9. Moore honored with American Statistical Association award

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated Codes |IsLove Your1 SECTIONES2008-54174 ThisBackground TheandAmerican

  10. Identifying HotSpots in Lung Cancer Data Using Association Rule Mining Ankit Agrawal and Alok Choudhary

    E-Print Network [OSTI]

    Kuzmanovic, Aleksandar

    Identifying HotSpots in Lung Cancer Data Using Association Rule Mining Ankit Agrawal and Alok, IL 60201, USA Email: {ankitag,choudhar}@eecs.northwestern.edu Abstract--We analyze the lung cancer. The resulting rules conform with existing biomedical knowledge and provide interesting insights into lung cancer

  11. Guidelines for Term Papers American Psychological Association 6

    E-Print Network [OSTI]

    Kasman, Alex

    Guidelines for Term Papers American Psychological Association ­ 6 th edition, 2010 Information from-spaced, alphabetized, using the hanging indention function. INDENTATION: Paragraphs: Indent five spaces the first line of each paragraph. (The tab key should be set to this amount and can be used to indent at the beginning

  12. QER- Comment of American Public Power Association 6

    Broader source: Energy.gov [DOE]

    To whom it may concern: Please find attached comments jointly filed by the American Public Power Association, Large Public Power Council, and Transmission Access Policy Study Group, in relation to the issues discussed at the October 6, 2014, QER Public Stakeholder Meeting on Finance (Transmission, Storage and Distribution).

  13. American Gas Association | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed off Energy.gov. Are you0 ARRA Newsletters 20103-03EnergyAlternativeAmerica's NextAssociation

  14. External Fellowships American Psychological Association (APA) Minority Fellowship Program (MFP) Research Training

    E-Print Network [OSTI]

    Ford, James

    Program: http://www.sreb.org/page/1074/doctoral_scholars.html February American Statistical Association.aera.net/grantsprogram/res_training/diss_grants/DGFly.html American Statistical Association: Mary G. and Joseph Natrella Scholarship: httpExternal Fellowships January American Psychological Association (APA) Minority Fellowship Program

  15. University of Calgary Press Canadian Association of Latin American and Caribbean Studies

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    University of Calgary Press Canadian Association of Latin American and Caribbean Studies REDES DUARTE Source: Canadian Journal of Latin American and Caribbean Studies / Revue canadienne des études Press on behalf of Canadian Association of Latin American and Caribbean Studies Stable URL: http

  16. AGA encouraging industry to adopt gas option. [American Gas Association

    SciTech Connect (OSTI)

    Lawrence, G.H.

    1980-03-03T23:59:59.000Z

    The American Gas Association (AGA) supports a policy of increasing conventional natural gas production and sustaining the higher level for at least 40 years in addition to developing unconventional sources by coal gasification, methane, biomass, and other technologies. International efforts to shift from petroleum to gas are responding to the need for appropriate policies. With gas supplying 40% of the energy consumed by American buildings and by industry and agriculture, the country has a significant financial investment in equipment and distribution systems. Although deregulation of gas prices will not prevent a decline in conventional production for the next decade, new sources and technologies will combine to maintain supplies. Policies are needed to enhance the US coal gasification capability and to promote the use of dual-fired furnaces. The worldwide gas option is an appropriate to other oil-importing countries as it is to the US. (DCK)

  17. ASA HONORS 63 NEW FELLOWS ALEXANDRIA VA, JUNE 11, 2014 The American Statistical Association (ASA), the nation's preeminent

    E-Print Network [OSTI]

    Zhu, Mu

    1 ASA HONORS 63 NEW FELLOWS ALEXANDRIA VA, JUNE 11, 2014 ­ The American Statistical Association the American Statistical Association The American Statistical Association is the world's largest community information about the American Statistical Association, please visit the ASA website at www

  18. american erionite-associated mesothelioma: Topics by E-print...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    K 1998-01-01 160 Socioeconomic Characteristics of American Indians in Los Angeles County University of California eScholarship Repository Summary: American Indians is critical...

  19. Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury

    E-Print Network [OSTI]

    Sapru, Anil; Curley, Martha A.; Brady, Sandra; Matthay, Michael A.; Flori, Heidi

    2010-01-01T23:59:59.000Z

    pediatric patients with acute lung injury Abstract Purpose:in part at the mark of acute lung injury (ALI). Society fordistress syndrome Á Acute lung injury Á Clinical studies Á

  20. QER- Comment of American Public Power Association 1

    Broader source: Energy.gov [DOE]

    Attached are the American Public Power Association 's (APPA) statement for the April 11 QER public meeting, Duane Highley's statement for the same meeting since we reference it, and Sue Kelly's (APPA President & CEO) testimony from last Thursday's (April 10) Senate Energy and Natural Resources Committee hearing entitled "Keeping the Lights On – Are We Doing Enough to Ensure the Reliability and Security of the US Electric Grid?" since her testimony covers everything in regards to this meeting. Thank you in advance for your consideration of our attached documents for the QER. Please let me know if you have any questions. Best, Seth Seth Voyles Director, Government Relations 1875 Connecticut Ave., NW, Suite 1200, Washington, D.C. 20009-5715 www.publicpower.org

  1. Lung cancer-derived Dickkopf1 is associated with bone metastasis and the mechanism involves the inhibition of osteoblast differentiation

    SciTech Connect (OSTI)

    Chu, Tianqing; Teng, Jiajun; Jiang, Liyan; Zhong, Hua; Han, Baohui, E-mail: baohuihan1@163.com

    2014-01-17T23:59:59.000Z

    Highlights: •DKK1 level was associated with NSCLC bone metastases. •Lung tumor cells derived DKK1 inhibited osteoblast differentiation. •Lung tumor cells derived DKK1 modulates ?-catenin and RUNX2. -- Abstract: Wnt/?-catenin signaling and Dickkopf1 (DKK1) play important roles in the progression of lung cancer, which preferably metastasizes to skeleton. But the role of them in bone dissemination is poorly understood. This study aims to define the role of DKK1 in lung cancer bone metastases and investigate the underlying mechanism. Our results demonstrated that DKK1 over-expression was a frequent event in non-small-cell lung cancer (NSCLC) blood samples, and serous DKK1 level was much higher in bone metastatic NSCLC compared to non-bone metastatic NSCLC. We also found that conditioned medium from DKK1 over-expressing lung cancer cells inhibited the differentiation of osteoblast, determined by alkaline phosphatase activity and osteocalcin secretion, whereas the conditioned medium from DKK1 silencing lung cancer cells exhibited the opposite effects. Mechanistically, DKK1 reduced the level of ?-catenin and RUNX2, as well as inhibiting the nuclear translocation of ?-catenin. Taken together, these results suggested that lung cancer-produced DKK1 may be an important mechanistic link between NSCLC and bone metastases, and targeting DKK1 may be an effective method to treat bone metastase of NSCLC.

  2. ISSN: 1524-4563 Copyright 2006 American Heart Association. All rights reserved. Print ISSN: 0194-911X. Online

    E-Print Network [OSTI]

    Hammock, Bruce D.

    ISSN: 1524-4563 Copyright © 2006 American Heart Association. All rights reserved. Print ISSN: 0194-911X. Online 72514 Hypertension is published by the American Heart Association. 7272 Greenville Avenue

  3. ISSN: 1524-4571 Copyright 2005 American Heart Association. All rights reserved. Print ISSN: 0009-7330. Online

    E-Print Network [OSTI]

    Hammock, Bruce D.

    ISSN: 1524-4571 Copyright © 2005 American Heart Association. All rights reserved. Print ISSN: 0009-7330. Online TX 72514 Circulation Research is published by the American Heart Association. 7272 Greenville

  4. ISSN: 1524-4563 Copyright 2005 American Heart Association. All rights reserved. Print ISSN: 0194-911X. Online

    E-Print Network [OSTI]

    Hammock, Bruce D.

    ISSN: 1524-4563 Copyright © 2005 American Heart Association. All rights reserved. Print ISSN: 0194-911X. Online 72514 Hypertension is published by the American Heart Association. 7272 Greenville Avenue

  5. ISSN: 1524-4636 Copyright 2010 American Heart Association. All rights reserved. Print ISSN: 1079-5642. Online

    E-Print Network [OSTI]

    Hammock, Bruce D.

    ISSN: 1524-4636 Copyright © 2010 American Heart Association. All rights reserved. Print ISSN: 1079 is published by the American Heart Association. DOI: 10.1161/ATVBAHA.110.204099 2010; 2010

  6. ISSN: 1524-4563 Copyright 2008 American Heart Association. All rights reserved. Print ISSN: 0194-911X. Online

    E-Print Network [OSTI]

    Hammock, Bruce D.

    ISSN: 1524-4563 Copyright © 2008 American Heart Association. All rights reserved. Print ISSN: 0194-911X. Online 72514 Hypertension is published by the American Heart Association. 7272 Greenville Avenue

  7. ISSN: 1524-4636 Copyright 2007 American Heart Association. All rights reserved. Print ISSN: 1079-5642. Online

    E-Print Network [OSTI]

    Hammock, Bruce D.

    ISSN: 1524-4636 Copyright © 2007 American Heart Association. All rights reserved. Print ISSN: 1079 is published by the American Heart Association. DOI: 10.1161/ATVBAHA.107.152074 13, 2007; 2007

  8. ISSN: 1524-4636 Copyright 2008 American Heart Association. All rights reserved. Print ISSN: 1079-5642. Online

    E-Print Network [OSTI]

    Ismagilov, Rustem F.

    ISSN: 1524-4636 Copyright © 2008 American Heart Association. All rights reserved. Print ISSN: 1079 is published by the American Heart Association. DOI: 10.1161/ATVBAHA.108.173930 Aug 14, 2008; 2008

  9. American Statistical Association Announces 2011 Award Recipients Awards ceremony to be held at Joint Statistical Meetings in Miami Beach, FL

    E-Print Network [OSTI]

    Washington at Seattle, University of

    American Statistical Association Announces 2011 Award Recipients Awards ceremony to be held at Joint Statistical Meetings in Miami Beach, FL MIAMI BEACH, FL (PRWEB) AUGUST 1, 2011 ­ The American Statistical Association (ASA), the nation's preeminent professional statistical society, today announced

  10. american surgical association: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of Materials Research (DMR) and funding organizations in Africa, Asia and Europe. Funding organizations in t Massachusetts at Lowell, University of 10 American Economic...

  11. american gastroenterological association: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of Materials Research (DMR) and funding organizations in Africa, Asia and Europe. Funding organizations in t Massachusetts at Lowell, University of 12 American Economic...

  12. american urological association: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of Materials Research (DMR) and funding organizations in Africa, Asia and Europe. Funding organizations in t Massachusetts at Lowell, University of 13 American Economic...

  13. African American Federal Executive Association, Inc. 9th Annual Training Workshop

    Broader source: Energy.gov [DOE]

    The African American Federal Executive Association, Inc. (AAFEA) will hold its 9th Annual Training Workshop (TW) September 16-17, 2013 in Washington, DC.  The theme of this year’s TW is “LEADING...

  14. IMPAIRED PHYSICIAN FOCUS ON SUBSTANCE ABUSE 1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders IV.

    E-Print Network [OSTI]

    Yates, Andrew

    IMPAIRED PHYSICIAN FOCUS ON SUBSTANCE ABUSE REFERENCES 1 1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders IV. 4th ed. Washington, DC: American Psychiatric Association; 1994. 2. American Society of Addiction Medicine. Patient Placement Criteria for the Treatment

  15. Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study

    E-Print Network [OSTI]

    Niu, Nifang

    Background: Taxane is one of the first line treatments of lung cancer. In order to identify novel single nucleotide polymorphisms (SNPs) that might contribute to taxane response, we performed a genome-wide association study ...

  16. Comment submitted by the North American Association of Food Equipment Manufacturers (NAFEM) regarding the Energy Star Verification Testing Program

    Broader source: Energy.gov [DOE]

    This document is a comment submitted by the North American Association of Food Equipment Manufacturers (NAFEM) regarding the Energy Star Verification Testing Program

  17. American Gas Association (AGA) for DOE Furnace Product Class | Department

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you're a16-17,2-13) All Other EditionsAmandaAmericanTurningof

  18. CDK-associated Cullin 1 promotes cell proliferation with activation of ERK1/2 in human lung cancer A549 cells

    SciTech Connect (OSTI)

    Chen, Tian Jun [Respiratory Department, The First Affiliated Hospital, Xi’an Jiaotong University College of Medicine, Xi’an 710061 (China)] [Respiratory Department, The First Affiliated Hospital, Xi’an Jiaotong University College of Medicine, Xi’an 710061 (China); Gao, Fei [Hua-shan Central Hospital of Xi’an, Xi’an 710043 (China)] [Hua-shan Central Hospital of Xi’an, Xi’an 710043 (China); Yang, Tian; Thakur, Asmitanand; Ren, Hui; Li, Yang; Zhang, Shuo; Wang, Ting [Respiratory Department, The First Affiliated Hospital, Xi’an Jiaotong University College of Medicine, Xi’an 710061 (China)] [Respiratory Department, The First Affiliated Hospital, Xi’an Jiaotong University College of Medicine, Xi’an 710061 (China); Chen, Ming Wei, E-mail: xjtucmw@163.com [Respiratory Department, The First Affiliated Hospital, Xi’an Jiaotong University College of Medicine, Xi’an 710061 (China)

    2013-07-19T23:59:59.000Z

    Highlights: •CDK-associated Cullin 1 (CAC1) expression increases in human lung carcinoma. •CAC1 promotes the proliferation of lung cancer A549 cells. •CAC1 promotes human lung cancer A549 cell proliferation with activation of ERK1/2. -- Abstract: Lung cancer is one of the most common causes of cancer-related death in the world, but the mechanisms remain unknown. In this study, we investigated the expression of CDK-associated Cullin 1 (CAC1) in lung cancer, the effect of CAC1 on the proliferation of human lung cancer A549 cells, and the activation of signaling pathways of mitogen-activated protein kinases (MAPKs). Results showed that CAC1 expression was higher levels in human lung carcinoma than normal lung tissue, and CAC1 siRNA reduced the proliferation of lung cancer A549 cells by decreasing cell activity and cell division in vitro. The proportion of cells treated with CAC1 siRNA increased in the G1 phase and decreased in the S and G2/M phase, indicative of G1 cell cycle arrest. Furthermore, the proportions of early/late apoptosis in lung cancer A549 cells were enhanced with CAC1 siRNA treatment. It was also found that activation of extracellular signal-regulated protein kinase (ERK) and p38 signaling pathways were involved in the proliferation of A549 cells. After CAC1 siRNA treatment, p-ERK1/2 levels decreased, and meanwhile p-p38 level increased, A549 cell proliferation increased when ERK1/2 signaling is activated by PMA. Our findings demonstrated that CAC1 promoted the proliferation of human lung cancer A549 cells with activation of ERK1/2 signaling pathways, suggesting a potential cure target for treatment of human lung cancer.

  19. ISSN: 1524-4571 Copyright 2006 American Heart Association. All rights reserved. Print ISSN: 0009-7330. Online

    E-Print Network [OSTI]

    Hammock, Bruce D.

    ISSN: 1524-4571 Copyright © 2006 American Heart Association. All rights reserved. Print ISSN: 0009-7330. Online TX 72514 Circulation Research is published by the American Heart Association. 7272 Greenville Function Role of Soluble Epoxide Hydrolase in Postischemic Recovery of Heart http

  20. Aerosol Science and Technology, 43:641652, 2009 Copyright American Association for Aerosol Research

    E-Print Network [OSTI]

    Aerosol Science and Technology, 43:641­652, 2009 Copyright © American Association for Aerosol is the irreversibility of the hygroscopic growth fac- tor of aerosol particles. The instrument uses the hysteresis for ideal instrument performance in application to a test aerosol of fully deliquesce- able particles

  1. Aerosol Science and Technology, 43:799807, 2009 Copyright American Association for Aerosol Research

    E-Print Network [OSTI]

    Aerosol Science and Technology, 43:799­807, 2009 Copyright © American Association for Aerosol and Efflorescence of Potassium Salts Relevant to Biomass-Burning Aerosol Particles Evelyn J. Freney,1 Scot T. Martin mate- rial into the atmosphere. Such aerosol particles affect the climate in part because

  2. Aerosol Science and Technology, 42:115, 2008 Copyright c American Association for Aerosol Research

    E-Print Network [OSTI]

    Aerosol Science and Technology, 42:1­15, 2008 Copyright c American Association for Aerosol Research of a Fast-Response Aerosol Size Spectrometer Jason S. Olfert and Jian Wang Atmospheric Science Department by the mixing of the aerosol in the inlet of the instrument, which `smears' the detected aerosol over a range

  3. Aerosol Science and Technology, 47:9398, 2013 Copyright C American Association for Aerosol Research

    E-Print Network [OSTI]

    Huang, Jiaxing

    Aerosol Science and Technology, 47:93­98, 2013 Copyright C American Association for Aerosol of Pt-Nanoparticles-Laden Graphene Crumples by Aerosol Spray Pyrolysis and Evaluation of aqueous chloroplatinic acid (H2PtCl6) and graphene oxide (GO) sheets via aerosol spray pyrol- ysis (ASP

  4. Aerosol Science and Technology, 46:12391245, 2012 Copyright C American Association for Aerosol Research

    E-Print Network [OSTI]

    Nizkorodov, Sergey

    Aerosol Science and Technology, 46:1239­1245, 2012 Copyright C American Association for Aerosol of Surfactants in Nanoparticles Produced by an Electrospray Aerosol Generator Amanda C. MacMillan,1 John B, USA Electrospray aerosol generators (EAGs) disperse conducting solutions into air, promptly neutralize

  5. Aerosol Science and Technology, 41:10891101, 2007 Copyright c American Association for Aerosol Research

    E-Print Network [OSTI]

    Aerosol Science and Technology, 41:1089­1101, 2007 Copyright c American Association for Aerosol Interferometric Aerosol Absorption Spectrometry Arthur Sedlacek and Jeonghoon Lee Brookhaven National Laboratory, Atmospheric Sciences, Upton, New York, USA Aerosol light absorption still remains a difficult quantity to mea

  6. Aerosol Science and Technology, 40:97106, 2006 Copyright c American Association for Aerosol Research

    E-Print Network [OSTI]

    Aerosol Science and Technology, 40:97­106, 2006 Copyright c American Association for Aerosol the aerosol particles, namely by vaporizing and condensing granular sodium chloride and by electrospraying materials are available for this article. Go to the publisher's online edition of Aerosol Science and Tech

  7. Aerosol Science and Technology, 46:937949, 2012 Copyright C American Association for Aerosol Research

    E-Print Network [OSTI]

    Aerosol Science and Technology, 46:937­949, 2012 Copyright C American Association for Aerosol Distributions following Condensational Growth in Continuous Flow Aerosol Reactors as Derived from Residence Time Distributions: Theoretical Development and Application to Secondary Organic Aerosol Mikinori Kuwata and Scot T

  8. Aerosol Science and Technology, 44:11401145, 2010 Copyright American Association for Aerosol Research

    E-Print Network [OSTI]

    Huang, Jiaxing

    Aerosol Science and Technology, 44:1140­1145, 2010 Copyright © American Association for Aerosol-Assembly of Nanoparticles in Evaporating Aerosol Droplets: Preparation of Nanoporous Pt/TiO2 Composite Particles Hee Dong, USA Nanoporous Pt/TiO2 micro-particles were synthesized via an aerosol assisted co-assembly (AACA

  9. American Wind Energy Association, Denver, May 2005 Uncertainties in Results of Measure-Correlate-Predict Analyses

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    American Wind Energy Association, Denver, May 2005 Uncertainties in Results of Measure-correlate-predict (MCP) algorithms are used to predict the wind resource at target sites for wind power development. MCP methods model the relationship between wind data (speed and direction) measured at the target site

  10. CHAPTER 6. BIBLIOGRAPHY AAPG 2005--American Association of Petroleum Geologists. Recent Uranium Industry Developments,

    E-Print Network [OSTI]

    Industry Developments, Exploration, Mining and Environmental Programs in the U.S. and Overseas. Uranium6-1 CHAPTER 6. BIBLIOGRAPHY AAPG 2005--American Association of Petroleum Geologists. Recent Uranium Committee, Energy Minerals Division. Tulsa, OK: March 25, 2005. http://emd.aapg.org/technical areas/uranium

  11. THE JOURNAL OF THE AMERICAN PUBLIC GARDENS ASSOCIATION VOL 28, NO 1 2013 VISITOR-CENTRIC

    E-Print Network [OSTI]

    Pasternack, Gregory B.

    THE JOURNAL OF THE AMERICAN PUBLIC GARDENS ASSOCIATION VOL 28, NO 1 · 2013 VISITOR on the power of collaboration and the energy of co-creation. Our leadership style--highly adaptive, experimental, and very inclusive--seeks to harness the energy of collaboration. We leverage funds, goodwill

  12. WATER RESOURCES BULLETIN AMERICAN WATER RESOURCES ASSOCIATION JUNE 1993VOL. 29, NO.3

    E-Print Network [OSTI]

    MacDonald, Lee

    WATER RESOURCES BULLETIN AMERICAN WATER RESOURCES ASSOCIATION JUNE 1993VOL. 29, NO.3 DEVELOPING the lack of a field and laboratory component in hydrologic education at the uni- versity level. Cons~uences of this lack include: (1) an unwan"anted faith in published data; (2) lack of appreciation for the spatial

  13. The association between fatalistic beliefs and late stage at diagnosis of lung and colorectal cancer

    E-Print Network [OSTI]

    Lyratzopoulos, Georgios; Liu, Michael Pang-Hsiang; Abel, Gary A.; Wardle, Jane; Keating, Nancy L.

    2015-02-03T23:59:59.000Z

    -based cohort of 4,319 U.S. patients with newly-diagnosed lung or colorectal cancer participating in the Cancer Care Outcomes and Research Surveillance (CanCORS) study. Fatalistic beliefs were assessed with an established measure. A fatalism score (range 4...

  14. Amit,Y.,Grenander,U. and Piccioni,M(1991), Structural image restoration through deformable templates, Jour nal of the American Statistical Association 86 376387.

    E-Print Network [OSTI]

    Iba, Yukito

    1991-01-01T23:59:59.000Z

    templates, Jour­ nal of the American Statistical Association 86 376­387. Barry,D. and Hartigan,J.A.(1993), A Bayesian analysis for change point problems, Journal of the American Statistical Association 88 309 to nonnormal and nonlinear state­ space modeling, Journal of the American Statistical Association 87 493

  15. Adjuvant and Salvage Radiation Therapy After Prostatectomy: American Society for Radiation Oncology/American Urological Association Guidelines

    SciTech Connect (OSTI)

    Valicenti, Richard K., E-mail: Richard.valicenti@ucdmc.ucdavis.edu [Department of Radiation Oncology, University of California, Davis School of Medicine, Davis, California (United States); Thompson, Ian [Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, Texas (United States); Albertsen, Peter [Division of Urology, University of Connecticut Health Center, Farmington, Connecticut (United States); Davis, Brian J. [Department of Radiation Oncology, Mayo Medical School, Rochester, Minnesota (United States); Goldenberg, S. Larry [Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia (Canada); Wolf, J. Stuart [Department of Urology, University of Michigan, Ann Arbor, Michigan (United States); Sartor, Oliver [Department of Medicine and Urology, Tulane Medical School, New Orleans, Louisiana (United States); Klein, Eric [Glickman Urological Kidney Institute, Cleveland Clinic, Cleveland, Ohio (United States); Hahn, Carol [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States); Michalski, Jeff [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri (United States); Roach, Mack [Department of Radiation Oncology, University of California, San Francisco, San Francisco, California (United States); Faraday, Martha M. [Four Oaks, Inc (United States)

    2013-08-01T23:59:59.000Z

    Purpose: The purpose of this guideline was to provide a clinical framework for the use of radiation therapy after radical prostatectomy as adjuvant or salvage therapy. Methods and Materials: A systematic literature review using PubMed, Embase, and Cochrane database was conducted to identify peer-reviewed publications relevant to the use of radiation therapy after prostatectomy. The review yielded 294 articles; these publications were used to create the evidence-based guideline statements. Additional guidance is provided as Clinical Principles when insufficient evidence existed. Results: Guideline statements are provided for patient counseling, use of radiation therapy in the adjuvant and salvage contexts, defining biochemical recurrence, and conducting a restaging evaluation. Conclusions: Physicians should offer adjuvant radiation therapy to patients with adverse pathologic findings at prostatectomy (ie, seminal vesicle invastion, positive surgical margins, extraprostatic extension) and salvage radiation therapy to patients with prostate-specific antigen (PSA) or local recurrence after prostatectomy in whom there is no evidence of distant metastatic disease. The offer of radiation therapy should be made in the context of a thoughtful discussion of possible short- and long-term side effects of radiation therapy as well as the potential benefits of preventing recurrence. The decision to administer radiation therapy should be made by the patient and the multidisciplinary treatment team with full consideration of the patient's history, values, preferences, quality of life, and functional status. The American Society for Radiation Oncology and American Urological Association websites show this guideline in its entirety, including the full literature review.

  16. Association Between White Blood Cell Count Following Radiation Therapy With Radiation Pneumonitis in Non-Small Cell Lung Cancer

    SciTech Connect (OSTI)

    Tang, Chad; Gomez, Daniel R. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Wang, Hongmei [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou (China); Levy, Lawrence B. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Zhuang, Yan [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Xu, Ting; Nguyen, Quynh; Komaki, Ritsuko [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Liao, Zhongxing, E-mail: zliao@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2014-02-01T23:59:59.000Z

    Purpose: Radiation pneumonitis (RP) is an inflammatory response to radiation therapy (RT). We assessed the association between RP and white blood cell (WBC) count, an established metric of systemic inflammation, after RT for non-small cell lung cancer. Methods and Materials: We retrospectively analyzed 366 patients with non-small cell lung cancer who received ?60 Gy as definitive therapy. The primary endpoint was whether WBC count after RT (defined as 2 weeks through 3 months after RT completion) was associated with grade ?3 or grade ?2 RP. Median lung volume receiving ?20 Gy (V{sub 20}) was 31%, and post-RT WBC counts ranged from 1.7 to 21.2 × 10{sup 3} WBCs/?L. Odds ratios (ORs) associating clinical variables and post-RT WBC counts with RP were calculated via logistic regression. A recursive-partitioning algorithm was used to define optimal post-RT WBC count cut points. Results: Post-RT WBC counts were significantly higher in patients with grade ?3 RP than without (P<.05). Optimal cut points for post-RT WBC count were found to be 7.4 and 8.0 × 10{sup 3}/?L for grade ?3 and ?2 RP, respectively. Univariate analysis revealed significant associations between post-RT WBC count and grade ?3 (n=46, OR=2.6, 95% confidence interval [CI] 1.4?4.9, P=.003) and grade ?2 RP (n=164, OR=2.0, 95% CI 1.2?3.4, P=.01). This association held in a stepwise multivariate regression. Of note, V{sub 20} was found to be significantly associated with grade ?2 RP (OR=2.2, 95% CI 1.2?3.4, P=.01) and trended toward significance for grade ?3 RP (OR=1.9, 95% CI 1.0-3.5, P=.06). Conclusions: Post-RT WBC counts were significantly and independently associated with RP and have potential utility as a diagnostic or predictive marker for this toxicity.

  17. aallll IIrreell aanndd ccaanncceerr ssttaattiissttiiccss sseeccoonndd rreeppoorrtt 11999988--22000000 Lung cancer Lung cancer Lung cancer Lung c

    E-Print Network [OSTI]

    Paxton, Anthony T.

    --22000000 34 Lung cancer Lung cancer Lung cancer Lung c ancer Lung cancer Lung cancer Lung cancer L ung cancer Lung cancer Lung cancer Lung can cer Lung cancer Lung cancer Lung cancer Lun g cancer Lung cancer Lung cancer Lung cance r Lung cancer Lung cancer Lung cancer Lung cancer Lung cancer Lung cancer Lung cancer

  18. Complications associated with brachytherapy alone or with laser in lung cancer

    SciTech Connect (OSTI)

    Khanavkar, B.; Stern, P.; Alberti, W.; Nakhosteen, J.A. (Augusta Teaching Hospital, Bochum (West Germany))

    1991-05-01T23:59:59.000Z

    Relatively little has been reported about destruction through brachytherapy of mucosa-perforating and extraluminary tumors with probable large vessel involvement causing major hemorrhagic or fistular complications. We report 12 patients subjected to laser and brachytherapy for centrally occluding lung cancer, whom we have periodically followed up from June 1986 until they died. Although all laser procedures were free from complications, necrotic cavitation in five cases, two of which were accompanied by large bronchoesophageal fistulas, and massive fatal hemoptysis occurred in six. Minor complications included radiation mucositis (two), noncritical mucosal scarring (two), and cough (four). Characteristics that will identify patients at risk of developing fatal hemoptysis and fistulas should be better defined by imaging and endoscopic techniques. In such cases, modifying the protocol or using alternative procedures should be considered. Minor complications, such as cough, can be avoided by using topical steroid therapy (eg, beclomethasone dipropionate).

  19. Organization Web Link American Association for Retired Person's http://www.grandfactsheets.org/doc/oklahoma07-final.pdf

    E-Print Network [OSTI]

    Veiga, Pedro Manuel Barbosa

    Organization Web Link American Association for Retired Person's http://www.grandfactsheets.org/doc/oklahoma-572-6831 Address: 1414 S. Division, Guthrie, OK 73044 Phone: 405-264-2700 , 800-572-6831 Oklahoma, North Address: 2409 N. Kelly, P.O. Box 26768, Oklahoma City, OK 73126 Phone: 405-522-5818, 800-884-1534 Address: 2409

  20. Functional Promoter Variant rs2868371 of HSPB1 Is Associated With Risk of Radiation Pneumonitis After Chemoradiation for Non-Small Cell Lung Cancer

    SciTech Connect (OSTI)

    Pang, Qingsong [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States) [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States); Department of Radiation Oncology and Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin (China); Wei, Qingyi [Department of Epidemiology, The University of Texas MD Anderson Cancer Center (United States)] [Department of Epidemiology, The University of Texas MD Anderson Cancer Center (United States); Xu, Ting [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States)] [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States); Yuan, Xianglin [Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan (China)] [Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan (China); Lopez Guerra, Jose Luis [Department of Medicine, Universitat Autònoma de Barcelona (Spain)] [Department of Medicine, Universitat Autònoma de Barcelona (Spain); Levy, Lawrence B. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States)] [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States); Liu, Zhensheng [Department of Epidemiology, The University of Texas MD Anderson Cancer Center (United States)] [Department of Epidemiology, The University of Texas MD Anderson Cancer Center (United States); Gomez, Daniel R. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States)] [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States); Zhuang, Yan [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center (United States)] [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center (United States); Wang, Li-E. [Department of Epidemiology, The University of Texas MD Anderson Cancer Center (United States)] [Department of Epidemiology, The University of Texas MD Anderson Cancer Center (United States); Mohan, Radhe [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center (United States)] [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center (United States); Komaki, Ritsuko [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States)] [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States); Liao, Zhongxing, E-mail: zliao@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States)] [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center (United States)

    2013-04-01T23:59:59.000Z

    Purpose: To date, no biomarkers have been found to predict, before treatment, which patients will develop radiation pneumonitis (RP), a potentially fatal toxicity, after chemoradiation for lung cancer. We investigated potential associations between single nucleotide polymorphisms (SNPs) in HSPB1 and risk of RP after chemoradiation for non-small cell lung cancer (NSCLC). Methods and Materials: Subjects were patients with NSCLC treated with chemoradiation at 1 institution. The training data set comprised 146 patients treated from 1999 to July 2004; the validation data set was 125 patients treated from August 2004 to March 2010. We genotyped 2 functional SNPs of HSPB1 (rs2868370 and rs2868371) from all patients. We used Kaplan-Meier analysis to assess the risk of grade ?2 or ?3 RP in both data sets and a parametric log-logistic survival model to evaluate the association of HSPB1 genotypes with that risk. Results: Grade ?3 RP was experienced by 13% of those with CG/GG and 29% of those with CC genotype of HSPB1 rs2868371 in the training data set (P=.028); corresponding rates in the validation data set were 2% CG/GG and 14% CC (P=.02). Univariate and multivariate analysis confirmed the association of CC of HSPB1 rs2868371 with higher risk of grade ?3 RP than CG/GG after adjustment for sex, age, performance status, and lung mean dose. This association was validated both in the validation data set and with Harrell's C statistic. Conclusions: The CC genotype of HSPB1 rs2868371 was associated with severe RP after chemoradiation for NSCLC.

  1. LUNG CANCER 6. LUNG CANCER

    E-Print Network [OSTI]

    Paxton, Anthony T.

    LUNG CANCER 47 6. LUNG CANCER 6.1. SUMMARY Lung cancer was the third most common cancer in Ireland (Table 6.1). The average number of new lung cancer cases diagnosed each year was 1,000 in women and 1 for women and 1% for men. The risk of developing lung cancer up to the age of 74 was 1 in 37 for women and 1

  2. EV Community Readiness projects: American Lung Association of the Southwest (CO); Oregon Business Development Department (OR, WA)

    Broader source: Energy.gov [DOE]

    2013 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting

  3. Richness of plantinsect associations in Eocene Patagonia: A legacy for South American biodiversity

    E-Print Network [OSTI]

    Wilf, Peter

    and insect herbivory is sparse. We quantified insect feeding on 3,599 leaves from the speciose Laguna del- and middle-Eocene floras from the following sites in North America: Republic, WA; Green River, UT; and Sourdough, WY. We found significantly more damage diversity at Laguna del Hunco than in the North American

  4. The associate of applied science degree in dental hygiene is an intensive, full-time endeavor that prepares you to take the American

    E-Print Network [OSTI]

    Hartman, Chris

    DENTAL HYGIENE The associate of applied science degree in dental hygiene is an intensive, full-time endeavor that prepares you to take the American Dental Association National Board Dental Hygiene exam-CTC@ALASKA.EDU WWW.CTC.UAF.EDU DENTAL HYGIENE Visit the Dental Hygiene Website: WWW.CTC.UAF.EDU/DH SAMPLE COURSES

  5. 159L I t e R A t U R e C I t e D American Forest and Paper Association. 2009. Our industry-paper. Washington, DC: American Forest

    E-Print Network [OSTI]

    , water and people: drinking water supply and forest lands in the Northeast and Midwest United States. NA.]. 2008. Mapping U.S. forest biomass using nationwide forest inventory data and moderate resolution159L I t e R A t U R e C I t e D American Forest and Paper Association. 2009. Our industry

  6. Associations of symptoms related to isocyanate, ureaformol, and formophenolic exposures with respiratory symptoms and lung function in coal miners

    SciTech Connect (OSTI)

    Bertrand, J.P.; Simon, V.; Chau, N. [Houilleres Bassin Lorraine, Freyming Merlebach (France)

    2007-04-15T23:59:59.000Z

    The respiratory effects of diphenylmethane diisocyanate (MDI)-based resins and ureaformol- and formophenolic-based resins, used in coal mining, are unknown. This cross-sectional study of 354 miners evaluated respiratory health in miners with MDI-related symptoms (IS) and ureaformol/formophenolic-related symptoms (UFS). The protocol included clinical examination, chest radiograph, questionnaire on respiratory symptoms, smoking habit, job history, resin handling, and spirometry. Resin handling concerned 27.7% of the miners. IS affected 5.6%, and 1.4% also after work. UFS affected 22.6%, and 2.3% also after work. Wheezing affected 35.6%; chronic cough, expectoration, or bronchitis about 10%; dyspnea 5.4%; and asthma 2.8%. The miners with UFS had significantly more frequent chronic cough, expectoration, chronic bronchitis, dyspnea, and wheezing, whereas those with IS at and after work had markedly lower FVC, FEV1, MMEF, FEF50% and FEF25%. These findings raise the possibility of deleterious effects of exposures to MDI and ureaformol/ ormophenolic resins on respiratory health and lung function in coal miners during their working life.

  7. Bullous Lung Disease

    E-Print Network [OSTI]

    Goldberg, Corey; Carey, Kathleen E

    2013-01-01T23:59:59.000Z

    thorascopic surgery. Bullous Lung Disease REFERENCES 1.S, Kaiser LR. Giant bullous lung disease: evaluation,for bullous disease of the lung. Eur J Cardiothorac Surg.

  8. Jpurnal of the Americun Mosquito Control Assot'itttion,19(4):316-3ttl. 2003 Copyright e 2003 by the American Mosquito Control Association.Inc.

    E-Print Network [OSTI]

    Jpurnal of the Americun Mosquito Control Assot'itttion,19(4):316-3ttl. 2003 Copyright e 2003 by the American Mosquito Control Association.Inc. EXPANDED POLYSTYRENE(EPS)trLOATSF'ORSURVEILLANCE OF OCHLEROTATUS container-dwelling Aede.sand Ochlerotetus species.Eggs from Ochler- otatusjaponic.u.s,Oc. triseriotus, Oc

  9. Journal of Experimental Psychology: Copyright 1996 by the American Psychological Association, Inc. Human Perception and Performance 0096-1523/96/$3.00

    E-Print Network [OSTI]

    Todd, James T.

    Journal of Experimental Psychology: Copyright 1996 by the American Psychological Association, Inc. Human Perception and Performance 0096-1523/96/$3.00 1996, Vol. 22, No. 4, 930-944 Perception of Local Three-Dimensional Shape Flip Phillips and James T. Todd The Ohio State University The authors present

  10. Journal of Experimental Psychology: Copyright 1996 by the American Psychological Association, Inc. Human Perception and Performance 0096-1523/96/$3.00

    E-Print Network [OSTI]

    Todd, James T.

    Journal of Experimental Psychology: Copyright 1996 by the American Psychological Association, Inc. Human Perception and Performance 0096-1523/96/$3.00 1996, Vol. 22, No. 4, 869-878 Surface Range Universiteit Utrecht James T. Todd, J. Farley Norman, and Flip Phillips Ohio State University The authors

  11. Journal of Experimental Psychology: Copyright 1996 by the American Psychological Association, Inc. Human Perception and Performance 0096-1523/96/$3.00

    E-Print Network [OSTI]

    Todd, James T.

    Journal of Experimental Psychology: Copyright 1996 by the American Psychological Association, Inc. Human Perception and Performance 0096-1523/96/$3.00 1996, Vol. 22, No. 3, 695-706 Effects of Changing Viewing Conditions on the Perceived Structure of Smoothly Curved Surfaces James T. Todd Ohio State

  12. Hastie, T., Tibshirani, R. & Buja, A. (1994b), `Flexible discriminant analysis by optimal scoring', Journal of the American Statistical Association 89, 1255--

    E-Print Network [OSTI]

    Hastie, Trevor

    ', Journal of the American Statistical Association 89, 1255-- 1270. Hertz, J., Krogh, A. & Palmer, R. (1991. 1994a). References Becker, R., Chambers, J. & Wilks, A. (1988), The New S Language, WadsworthHastie, T., Tibshirani, R. & Buja, A. (1994b), `Flexible discriminant analysis by optimal scoring

  13. american subtropical area: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    English American Studies Sussex, University of 30 Grant Title: AMERICAN ASSOCIATION OF UNIVERSITY WOMEN (AAUW) -AMERICAN FELLOWSHIPS Funding Opportunity Number: NA Engineering...

  14. Influence of radiation therapy on the lung-tissue in breast cancer patients: CT-assessed density changes and associated symptoms

    SciTech Connect (OSTI)

    Rotstein, S.; Lax, I.; Svane, G. (Karolinska Hospital, Stockholm (Sweden))

    1990-01-01T23:59:59.000Z

    The relative electron density of lung tissue was measured from computer tomography (CT) slices in 33 breast cancer patients treated by various techniques of adjuvant radiotherapy. The measurements were made before radiotherapy, 3 months and 9 months after completion of radiation therapy. The changes in lung densities at 3 months and 9 months were compared to radiation induced radiological (CT) findings. In addition, subjective symptoms such as cough and dyspnoea were assessed before and after radiotherapy. It was observed that the mean of the relative electron density of lung tissue varied from 0.25 when the whole lung was considered to 0.17 when only the anterior lateral quarter of the lung was taken into account. In patients with positive radiological (CT) findings the mean lung density of the anterior lateral quarter increased 2.1 times 3 months after radiotherapy and was still increased 1.6 times 6 months later. For those patients without findings, in the CT pictures the corresponding values were 1.2 and 1.1, respectively. The standard deviation of the pixel values within the anterior lateral quarter of the lung increased 3.8 times and 3.2 times at 3 months and 9 months, respectively, in the former group, as opposed to 1.2 and 1.1 in the latter group. Thirteen patients had an increase in either cough or dyspnoea as observed 3 months after completion of radiotherapy. In eleven patients these symptoms persisted 6 months later. No significant correlation was found between radiological findings and subjective symptoms. However, when three different treatment techniques were compared among 29 patients the highest rate of radiological findings was observed in patients in which the largest lung volumes received the target dose. A tendency towards an increased rate of subjective symptoms was also found in this group.

  15. SUPPORT FOR CHEMISTRY SYMPOSIA AT THE 2011 AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE MEETING FEBRUARY 17-21, 2011

    SciTech Connect (OSTI)

    Prof. Charles Casey, University of Wisconsin-Madison

    2011-08-20T23:59:59.000Z

    This proposal supported Chemistry Symposia at the 2011 American Association for the Advancement of Science (AAAS) Meeting in Washington, DC February 17-21, 2011. The Chemistry Section of AAAS presented an unusually strong set of symposia for the 2011 AAAS meeting to help celebrate the 2011 International Year of Chemistry. The AAAS meeting provided an unusual opportunity to convey the excitement and importance of chemistry to a very broad audience and allowed access to a large contingent of the scientific press. Excellent suggestions for symposia were received from AAAS Chemistry Fellows and from the chairs of the American Chemical Society Technical Divisions. The AAAS Chemistry executive committee selected topics that would have wide appeal to scientists, the public, and the press for formal proposals of symposia. The symposia proposals were peer reviewed by AAAS. The Chemistry Section made a strong case to the program selection committee for approval of the chemistry symposia and 6 were approved for the 2011 annual meeting. The titles of the approved symposia were: (1) Powering the Planet: Generation of Clean Fuels from Sunlight and Water, (2) Biological Role and Consequences of Intrinsic Protein Disorder, (3) Chemically Speaking: How Organisms Talk to Each Other, (4) Molecular Self-Assembly and Artificial Molecular Machines, (5) Frontiers in Organic Materials for Information Processing, Energy and Sensors, and (6) Celebrating Marie Curie's 100th Anniversary of Her Nobel Prize in Chemistry. The Chemistry Section of AAAS is provided with funds to support only 1-2 symposia a year. Because of the much greater number of symposia approved in conjunction with observance of the 2011 International Year of Chemistry, additional support was sought from DOE to help support the 30 invited speakers and 8 symposia moderators/organizers. Support for the symposia provided the opportunity to highlight the excitement of current chemical research, to educate the public about the achievements of chemistry and its contributions to the well-being of humankind. The 2011 AAAS Annual Meeting provided an important opportunity to play a prominent role in the global celebration of the 2011 International Year of Chemistry.

  16. AMERICAN STATISTICAL ASSOCIATION

    U.S. Energy Information Administration (EIA) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro IndustriesTownDells,1 U.S. Department of Energygasoline pricessummer8Flow, 34AEP1) June 2013

  17. AMERICAN STATISTICAL ASSOCIATION

    U.S. Energy Information Administration (EIA) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro IndustriesTownDells,1 U.S. Department of Energygasoline pricessummer8Flow, 34AEP1) June 2013

  18. AMERICAN STATISTICAL ASSOCIATION

    U.S. Energy Information Administration (EIA) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro IndustriesTownDells,1 U.S. Department of Energygasoline pricessummer8Flow, 34AEP1) June 2013

  19. AMERICAN STATISTICAL ASSOCIATION (ASA)

    U.S. Energy Information Administration (EIA) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro IndustriesTownDells,1 U.S. Department of Energygasoline4Residential17.Keeping

  20. Advances in Lung Volume

    E-Print Network [OSTI]

    Jones, Michelle

    Advances in Lung Volume Reduction Surgery The Ohio University Medical Center Lung Volume Reduction LungVolumeReductionSurgery Spring 2010 © 2010 The Ohio State University Medical Center ­ 04 Consult Ohio State's #12;The Ohio State University Medical Center Lung Volume Reduction Surgery Patient

  1. Proceedings: 15th International American Coal Ash Association Symposium on Management and Use of Coal Combustion Products (CCPs): Building Partnerships for Sustainability

    SciTech Connect (OSTI)

    None

    2003-01-01T23:59:59.000Z

    Topics discussed at the 15th International American Coal Ash Association (ACAA) Symposium, ''Management and Use of Coal Combustion Products (CCPs),'' included fundamental CCP use, research, product marketing, applied research, CCP management and environmental issues, and commercial uses. There is a continuing international research interest in CCP use because of its commercial value and its environmental benefits, such as reducing greenhouse gas emissions, reducing landfill needs, and utilizing recycled materials instead of virgin materials. CCP use also can reduce disposal costs and generate revenue from CCP sales.

  2. Skin metastases from lung cancer

    E-Print Network [OSTI]

    Mollet, Todd W; Garcia, Carlos A; Koester, Glenn

    2009-01-01T23:59:59.000Z

    cutaneous metastases from the lung frequently indicate aof skin metastases from lung cancer. Intern Med. 1996; 35:9. Coslett LM, Katlic MR. Lung cancer with skin metastasis.

  3. A new mouse model to explore the initiation, progression, and therapy of BRAF(V600E)-induced lung tumors

    E-Print Network [OSTI]

    Dankort, David; Filenova, Elena; Collado, Manuel; Serrano, Manuel; Jones, Kirk; McMahon, Martin

    2007-01-01T23:59:59.000Z

    and RAS mutations in human lung cancer and melanoma. Cancerreceptor signaling pathway in lung cancers. Int. J. Can- ceractivated in non-small-cell lung cancer and associated with

  4. american indian women: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    communities Duarte, Meredith Laura 2012-01-01 24 Grant Title: AMERICAN ASSOCIATION OF UNIVERSITY WOMEN (AAUW) -AMERICAN FELLOWSHIPS Funding Opportunity Number: NA Engineering...

  5. Join us for the Third North American Congress

    E-Print Network [OSTI]

    Barthelat, Francois

    Oncology (ASPO) American Statistical Association-Epidemiology (ASA-EPI) Council of State and Territorial Society (AES) American Heart Association -Epidemiology Section(AHA-EPI) American Society for Preventive) International Society for Pharmacoepidemiology (ISPE) Mol Epi Group/American Association of Cancer Research (MEG

  6. Lung Link: Improved Artificial Lung Conduits Clinical Problem

    E-Print Network [OSTI]

    McGaughey, Alan

    Lung Link: Improved Artificial Lung Conduits Clinical Problem · Lung Disease takes nearly 335,000 lives each year in the Unites States alone and is a growing problem [1]. · The waiting list for lung]. · A new artificial and portable assistance device for the lung would aid extend patients lives until

  7. 2 A New Map of Global Ecological Land Units --An Ecophysiographic Stratification Approach A Special Publication of the Association of American Geographers 3 A New Map of Global Ecological Land Units --

    E-Print Network [OSTI]

    Fleskes, Joe

    disasters, 3) manage water, biological, energy, and mineral resources, and 4) enhance and protect our#12;2 A New Map of Global Ecological Land Units -- An Ecophysiographic Stratification Approach A Special Publication of the Association of American Geographers 3 A New Map of Global Ecological Land Units

  8. Submitted to the Journal of the American Water Resources Association Potential Human Health Effects Associated with Pathogens in Urban Wet Weather Flows

    E-Print Network [OSTI]

    Pitt, Robert E.

    Effects Associated with Pathogens in Urban Wet Weather Flows Robert Pitt1 , Melinda Lalor2 , and John stormwater conveyance systems, or wet weather sewage overflows, may adversely impact many of the desired uses. Urban runoff or wet weather flows include not only precipitation and washoff from lawns and landscaped

  9. Lung cancer...115 Chapter 11

    E-Print Network [OSTI]

    Paxton, Anthony T.

    NICR/NCRI Lung cancer...115 Chapter 11: Lung cancer (including trachea, bronchus and lung; C33-C34 of lung cancer diagnosed each year in Ireland during 2000-2004. o Male incidence rates decreased by 1 by 2.7%. o Higher levels of treatment occurred among those with small cell lung cancer (compared to non

  10. STATISTICAL MODELING OF THE LUNG NODULES IN LOW DOSE COMPUTED TOMOGRAPHY SCANS OF THE CHEST

    E-Print Network [OSTI]

    Louisville, University of

    the Center for Disease Control (CDC) of the United States reported 90139 men and 69078 women death cases due cancer is the second most common cancer in the United States among white, African American and American]. Research studies to reach an optimal detection rate for early detection of lung cancer, is the hope

  11. Weight Gain in Advanced Non-Small-Cell Lung Cancer Patients During Treatment With Split-Course Concurrent Chemoradiotherapy Is Associated With Superior Survival

    SciTech Connect (OSTI)

    Gielda, Benjamin T., E-mail: Benjamin_gielda@rush.edu [Department of Radiation Oncology, Rush University Medical Center, Chicago, IL (United States); Mehta, Par [Department of Radiation Oncology at Rush Copley Medical Center, Aurora, IL (United States); Khan, Atif [Department of Radiation Oncology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School and Cancer Institute of New Jersey, New Brunswick, NJ (United States); Marsh, James C.; Zusag, Thomas W. [Department of Radiation Oncology, Rush University Medical Center, Chicago, IL (United States); Warren, William H. [Department of Cardiothoracic Surgery, Rush University Medical Center, Chicago, IL (United States); Fidler, Mary Jo [Section of Medical Oncology, Rush University Medical Center, Chicago, IL (United States); Abrams, Ross A. [Department of Radiation Oncology, Rush University Medical Center, Chicago, IL (United States); Bonomi, Philip [Section of Medical Oncology, Rush University Medical Center, Chicago, IL (United States); Liptay, Michael; Faber, L. Penfield [Department of Cardiothoracic Surgery, Rush University Medical Center, Chicago, IL (United States)

    2011-11-15T23:59:59.000Z

    Background: Preoperative concurrent chemoradiotherapy (CRT) is an accepted treatment for potentially resectable, locally advanced, non-small-cell lung cancer (NSCLC). We reviewed a decade of single institution experience with preoperative split-course CRT followed by surgical resection to evaluate survival and identify factors that may be helpful in predicting outcome. Methods and Materials: All patients treated with preoperative split-course CRT and resection at Rush University Medical Center (RUMC) between January 1999 and December 2008 were retrospectively analyzed. Endpoints included overall survival (OS), progression-free survival (PFS), local-regional progression-free survival (LRPFS), and distant metastasis-free survival (DMFS). Patient and treatment related variables were assessed for correlation with outcomes. Results: A total of 54 patients were analyzed, 76% Stage IIIA, 18% Stage IIIB, and 6% oligometastatic. The pathologic complete response (pCR) rate was 31.5%, and the absence of nodal metastases (pN0) was 64.8%. Median OS and 3-year actuarial survival were 44.6 months and 50%, respectively. Univariate analysis revealed initial stage (p < 0.01) and percent weight change during CRT (p < 0.01) significantly correlated with PFS/OS. On multivariate analysis initial stage (HR, 2.4; 95% CI, 1.18-4.90; p = 0.02) and percent weight change (HR, 0.79; 95% CI, 0.67-0.93; p < 0.01) maintained significance with respect to OS. There were no cases of Grade 3+ esophagitis, and there was a single case of Grade 3 febrile neutropenia. Conclusions: The strong correlation between weight change during CRT and OS/PFS suggests that this clinical parameter may be useful as a complementary source of predictive information in addition to accepted factors such as pathological response.

  12. Decrements in Lung Function Related to Arsenic in Drinking Water in West Bengal, India

    E-Print Network [OSTI]

    California at Berkeley, University of

    Decrements in Lung Function Related to Arsenic in Drinking Water in West Bengal, India Ondine S­2000, the authors investigated relations between lung function, respiratory symptoms, and arsenic in drinking water, consumption of arsenic-contaminated water was associated with respiratory symptoms and reduced lung function

  13. Clinical Investigation: Breast Cancer Predicting the Risk of Secondary Lung Malignancies

    E-Print Network [OSTI]

    Brenner, David Jonathan

    Clinical Investigation: Breast Cancer Predicting the Risk of Secondary Lung Malignancies Associated. Accepted for publication Sep 19, 2011 Summary The risk of secondary lung cancers after whole breast lower risk of secondary lung malignancy than treatment with the supine breast tech- nique. Breast

  14. The Heparan Sulfate Proteoglycan GPC3 Is a Potential Lung Tumor Suppressor

    E-Print Network [OSTI]

    Tian, Weidong

    The Heparan Sulfate Proteoglycan GPC3 Is a Potential Lung Tumor Suppressor Han Kim,* Guo-Liang Xu University School of Medicine, Boston, Massachusetts Recently, we used gene expression profiling of lung pathways associated with ciga- rette smoking and lung carcinogenesis. The gene encoding Glypican 3

  15. Race Matters: Disparities in African-American Children with Attention Deficit Hyperactivity Disorder

    E-Print Network [OSTI]

    Omiecinski, Curtis

    . As defined by the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders) inattention, (2) impulsivity, and (3) hyperactivity, the American Psychiatric Association (APA) believed145 145 Race Matters: Disparities in African-American Children with Attention Deficit Hyperactivity

  16. The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis

    E-Print Network [OSTI]

    Niese, Kathryn A; Chiaramonte, Monica G; Ellies, Lesley G; Rothenberg, Marc E; Zimmermann, Nives

    2010-01-01T23:59:59.000Z

    acid transporter 2 is induced in inflammatory lung modelsand regulates lung fibrosis Respiratory Research 2010, 11:872 is induced in inflammatory lung models and regulates lung

  17. SU-E-J-249: Correlation of Mean Lung Ventilation Value with Ratio of Total Lung Volumes

    SciTech Connect (OSTI)

    Yu, N; Qu, H; Xia, P [Cleveland Clinic, Cleveland, OH (United States)

    2014-06-01T23:59:59.000Z

    Purpose: Lung ventilation function measured from 4D-CT and from breathing correlated CT images is a novel concept to incorporate the lung physiologic function into treatment planning of radiotherapy. The calculated ventilation functions may vary from different breathing patterns, affecting evaluation of the treatment plans. The purpose of this study is to correlate the mean lung ventilation value with the ratio of the total lung volumes obtained from the relevant CTs. Methods: A ventilation map was calculated from the variations of voxel-to-voxel CT densities from two breathing phases from either 4D-CT or breathing correlated CTs. An open source image registration tool of Plastimatch was used to deform the inhale phase images to the exhale phase images. To calculate the ventilation map inside lung, the whole lung was delineated and the tissue outside the lung was masked out. With a software tool developed in house, the 3D ventilation map was then converted in the DICOM format associated with the planning CT images. The ventilation map was analyzed on a clinical workstation. To correlate ventilation map thus calculated with lung volume change, the total lung volume change was compared the mean ventilation from our method. Results: Twenty two patients who underwent stereotactic body irradiation for lung cancer was selected for this retrospective study. For this group of patients, the ratio of lung volumes for the inhale (Vin ) and exhale phase (Vex ) was shown to be linearly related to the mean of the local ventilation (Vent), Vin/Vex=1.+0.49*Vent (R2=0.93, p<0.01). Conclusion: The total lung volume change is highly correlated with the mean of local ventilation. The mean of local ventilation may be useful to assess the patient's lung capacity.

  18. QUESTIONS & ANSWERS ABOUT LUNG CANCER

    E-Print Network [OSTI]

    QUESTIONS & ANSWERS ABOUT LUNG CANCER Q: What are the early signs of lung cancer? How would I know I have it? A: Some of the early warning signs of lung cancer are: · A cough that doesn't go away what may be causing these symptoms. Q: How is lung cancer diagnosed? A: Your doctor may do one or more

  19. WON EXPOSURE AND LUNG CANCER RISK

    E-Print Network [OSTI]

    unknown authors

    As information on indoor air quality accumulated * it became apparent that radon and its progeny are invariably present in indoor environments and that concentrations may reach unacceptably high levels. The lung cancer excess anong miners exposed to radon progeny raised concern that exposure to radon progeny might also cause lung cancer in the general population. This presentation first provides an ovemiew of radon daughter carcinogenesis, and then reviews the recent BEIR IV report. The report described a statistical model * based on analysis of data from four studies of miners, for estimating the lung cancer risk associated with exposure to radon progeny. Tbe analyses showed that the risk of radon exposure declines with time since exposure and with increasing age. The BEIR IV committee concluded that radon progeny and cigarette smoking interact in a multiplicative fashion and that exposure-dose relationships are similar for exposure in homes and in mines.

  20. Sandia National Laboratories: American Institute of Aeronautics...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Institute of Aeronautics and Astronautics Two Sandia Leaders Elected American Association for the Advancement of Science Fellows On December 15, 2014, in Climate, Energy,...

  1. Imaging Lung Disease in Systemic Sclerosis

    E-Print Network [OSTI]

    Strollo, Diane; Goldin, Jonathan

    2010-01-01T23:59:59.000Z

    undergoing surgical biopsy of the lung. Radiology 1997, 205:disease. In Pathology of the Lung. Edited by Thurlbeck WM,organs, most frequently the lungs and gastrointes- tinal

  2. Imaging Lung Disease in Systemic Sclerosis

    E-Print Network [OSTI]

    Strollo, Diane; Goldin, Jonathan

    2010-01-01T23:59:59.000Z

    W, et al. : Interstitial lung disease in progressiveGL, Myers JL: Diffuse lung disease: diagnostic accuracy ofsurgical biopsy of the lung. Radiology 1997, 205:229–234.

  3. Pneumothorax in a Single Lung Patient

    E-Print Network [OSTI]

    Sauneuf, Bertrand; Champigneulle, Benoit; Pène, Frédéric

    2012-01-01T23:59:59.000Z

    Pneumothorax in a Single Lung Patient Bertrand Sauneuf, MD*encapsulation of the diseased lung and containment of therevealed a single right lung expanded through the entire

  4. APA 6th is an author-year style from the American Psychological Association. This style is most commonly used in psychology, economics, education and health sciences.

    E-Print Network [OSTI]

    Johansen, Tom Henning

    on the guidelines for referencing given in chapters 6 and 7 of in the APA's Publication manual (American quote of 40 words or more is written as a separate, indented paragraph without quotation marks

  5. American Association of Petroleum Geologists

    E-Print Network [OSTI]

    Kaufman, Alan Jay

    Hyatt Regency, Crystal City Arlington, Virginia ON THE EDGE OF A NEW ENERGY FRONTIER #12;MEETING HOSTS Level of the Hyatt Regency -Crystal City (our host hotel). Sunday, September 25, 11:30 am ­ 7:30 pm in the Washington, DC, metro area, a rare opportunity to sample the latest tech- nology and make your voice heard

  6. The American Medical Association Foundation

    E-Print Network [OSTI]

    that America's first president wore wooden teeth. He is also credited with verifyingthe remains of Adolf Hitler

  7. Copyright American Museum of Natural History 2001 ISSN 0003-0082 PUBLISHED BY THE AMERICAN MUSEUM OF NATURAL HISTORY

    E-Print Network [OSTI]

    Clark, James M.

    Copyright American Museum of Natural History 2001 ISSN 0003-0082 PUBLISHED BY THE AMERICAN MUSEUM Associate Curator and Chairman, Department of Vertebrate Paleontology, Natural History Museum of Los Angeles, American Museum of Natural History. 2 Chairman, Division of Paleontology, American Museum of Natural

  8. Copyright American Museum of Natural History 2002 ISSN 0003-0082 PUBLISHED BY THE AMERICAN MUSEUM OF NATURAL HISTORY

    E-Print Network [OSTI]

    Clark, James M.

    Copyright American Museum of Natural History 2002 ISSN 0003-0082 PUBLISHED BY THE AMERICAN MUSEUM Washington University, Washington, DC 20052. Research Associate, Division of Paleontology, American Museum of Natural History. e-mail: jclark@gwu.edu 2 Chairman, Division of Paleontology, American Museum of Natural

  9. Does aluminum smelting cause lung disease

    SciTech Connect (OSTI)

    Abramson, M.J.; Wlodarczyk, J.H.; Saunders, N.A.; Hensley, M.J.

    1989-04-01T23:59:59.000Z

    The evidence concerning a relationship between work in the aluminum industry and lung disease has been reviewed using epidemiologic criteria. Adequate data on environmental exposure are rarely presented. Case series on aluminum potroom workers over the past 50 years have identified an asthmalike syndrome that appears to be due to an irritant rather than an allergic mechanism. These studies have been supported by evidence of within shift variability of measures of lung function. However, to date, there is inadequate evidence to resolve the question of whether potroom exposure initiates asthma or merely precipitates asthmalike symptoms in a predisposed individual. Cross-sectional studies have demonstrated evidence of reduced lung function, consistent with chronic airflow limitation. In exposed aluminum smelter workers compared to unexposed control subjects. Cigarette smoking, the major potential confounding variable, has been measured and accounted for in multivariate analyses. To date, evidence is lacking from longitudinal studies about the development of disabling chronic obstructive lung disease. Exposure to coal tar pitch volatiles in the production and consumption of anodes has biologic plausibility for an association of lung cancer with work in an aluminum smelter. Although retrospective mortality studies have failed to account for the probable high prevalence of smoking in blue collar workers, the relative risk of lung cancer is very low if present at all. Pulmonary fibrosis has not been shown to be a significant problem in aluminum smelter workers. Future research in the aluminum industry needs to concentrate on longitudinal studies, preferably with an inception cohort for the investigation of potroom asthma. 92 references.

  10. Lung pair phantom

    DOE Patents [OSTI]

    Olsen, Peter C. (West Richland, WA); Gordon, N. Ross (Kennewick, WA); Simmons, Kevin L. (Kennewick, WA)

    1993-01-01T23:59:59.000Z

    The present invention is a material and method of making the material that exhibits improved radiation attenuation simulation of real lungs, i.e., an "authentic lung tissue" or ALT phantom. Specifically, the ALT phantom is a two-part polyurethane medium density foam mixed with calcium carbonate, potassium carbonate if needed for K-40 background, lanthanum nitrate, acetone, and a nitrate or chloride form of a radionuclide. This formulation is found to closely match chemical composition and linear attenuation of real lungs. The ALT phantom material is made according to established procedures but without adding foaming agents or preparing thixotropic concentrate and with a modification for ensuring uniformity of density of the ALT phantom that is necessary for accurate simulation. The modification is that the polyurethane chemicals are mixed at a low temperature prior to pouring the polyurethane mixture into the mold.

  11. Lung pair phantom

    DOE Patents [OSTI]

    Olsen, P.C.; Gordon, N.R.; Simmons, K.L.

    1993-11-30T23:59:59.000Z

    The present invention is a material and method of making the material that exhibits improved radiation attenuation simulation of real lungs, i.e., an ``authentic lung tissue`` or ALT phantom. Specifically, the ALT phantom is a two-part polyurethane medium density foam mixed with calcium carbonate, potassium carbonate if needed for K-40 background, lanthanum nitrate, acetone, and a nitrate or chloride form of a radionuclide. This formulation is found to closely match chemical composition and linear attenuation of real lungs. The ALT phantom material is made according to established procedures but without adding foaming agents or preparing thixotropic concentrate and with a modification for ensuring uniformity of density of the ALT phantom that is necessary for accurate simulation. The modification is that the polyurethane chemicals are mixed at a low temperature prior to pouring the polyurethane mixture into the mold.

  12. Center for Latin American, Caribbean & Latino Studies Center for Latin American,

    E-Print Network [OSTI]

    Rosen, Jay

    CLACLS Center for Latin American, Caribbean & Latino Studies Center for Latin American, Caribbean Psychology Ph.D. Program Quantitative Research Associate Center for Latin American, Caribbean & Latino, Caribbean and Latino Studies is a research institute that works for the advancement of the study of Latin

  13. Early Lung Cancer Detection Program

    Broader source: Energy.gov [DOE]

    Since 2000, DOE has made screening for occupational lung cancer with low-dose helical computed tomography (CT) scans available to workers at high risk for lung cancer. Because former workers undertook essential activities to fulfill the Department's mission, many of them were at risk for lung cancer.

  14. Latin american and caribbean StudieS

    E-Print Network [OSTI]

    Dresden, Gregory

    209 Latin american and caribbean StudieS (LacS) cOre FacuLtY: Professor barnett AssociAte Professor MAyock AssistAnt Professors BottA, cArey, Dickovick, eAstwooD the Program in Latin american and caribbean, culture, and society as applied to the region of Latin America and the caribbean. the program's curriculum

  15. 1 American Studies AMERICAN STUDIES

    E-Print Network [OSTI]

    Vertes, Akos

    1 American Studies AMERICAN STUDIES An innovative department with 15 core faculty and 12 affiliated of culture, ideas and religious beliefs; the development and transformation of public cultures and spaces. Topics include the civil rights movement, the student movement, the Vietnam War, and the counterculture

  16. American Society for Quality Data Reconciliation and Gross Error Detection in Chemical Process Networks

    E-Print Network [OSTI]

    Bustamante, Fabián E.

    ), pp. 409-422 Published by: American Statistical Association and American Society for Quality Stable access to Technometrics. http://www.jstor.org #12;?1985 American Statistical Association of scholarship. For more information about JSTOR, please contact support@jstor.org. American Statistical

  17. American Society for Quality Procedures for Detecting Outlying Observations in Samples

    E-Print Network [OSTI]

    Masci, Frank

    Statistical Association and American Society for Quality Stable URL: http://www.jstor.org/stable/1266761@jstor.org. American Statistical Association and American Society for Quality are collaborating with JSTOR to digitize, Committee E-ll on Statistical Methods, The American Society for Testing Materials (ASTM). This work

  18. Lung Transplantation for Advanced Bronchiectasis

    E-Print Network [OSTI]

    Turner, Monica G.

    Lung Transplantation for Advanced Bronchiectasis Don Hayes Jr., M.D., F.A.A.P., F.A.C.P., F.C.C.P.1 and Keith C. Meyer, M.D., M.S., F.A.C.P., F.C.C.P.2 ABSTRACT Lung transplant (LT) can be successfully performed on patients with advanced bronchiectatic lung disease with subsequent good posttransplant quality

  19. Cutaneous metastasis of primitive neuroectodermal lung tumor

    E-Print Network [OSTI]

    Garcia Romero, Diana; Hilara Sanchez, Yolanda; Perez Alvarez, Javier; Ramirez Garcia, Jose Ramon; de Pable Martin, Maria Pilar

    2013-01-01T23:59:59.000Z

    neuroectodermal tumour of the lung: report of two cases.metastasis due to small-cell lung cancer: a case report.Cell Carcinoma of the Lung. Actas Dermosifiliogr. 2008;99:

  20. Respiratory survey of North American Indian children living in proximity to an aluminum smelter

    SciTech Connect (OSTI)

    Ernst, P.; Thomas, D.; Becklake, M.R.

    1986-02-01T23:59:59.000Z

    We explored the relationship of respiratory symptoms and lung function to exposure to ambient air pollution consisting of particulate and gaseous fluorides. The subjects were 253 North American Indian children 11 to 17 yr of age living on the Akwasasne reserve, which is adjacent to an aluminum smelter. Among boys, closing volume (CV/VC%) was increased in those raised closest to the smelter as opposed to those having lived most of their lives farthest from this source of air pollution. In both sexes, there was a significant linear relationship between increasing CV/VC% and the amount of fluoride contained in a spot urine sample. We conclude that exposure to fluoride air pollution in the community may be associated with abnormalities in small airways. The implication of these abnormalities for future respiratory health is unknown.

  1. Sandia Energy - American Institute of Aeronautics and Astronautics...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Astronautics Elects Sandian as Associate Fellow Home Renewable Energy Energy News Wind Energy News & Events American Institute of Aeronautics and Astronautics Elects Sandian as...

  2. Peptide targeting and imaging of damaged lung tissue in influenza-infected mice

    E-Print Network [OSTI]

    Li, Na

    In this study, we investigate whether pH (low) insertion peptide (pHLIP) can target regions of lung injury associated with influenza infection. Materials & methods: Fluorophore-conjugated pHLIP was injected intraperitoneally ...

  3. Automated segmentation of lungs with severe interstitial lung disease in CT

    E-Print Network [OSTI]

    Automated segmentation of lungs with severe interstitial lung disease in CT Jiahui Wang Department: Accurate segmentation of lungs with severe interstitial lung disease ILD in thoracic computed tomography CT developed in this study a texture analysis-based method for accurate segmentation of lungs with severe ILD

  4. Superthreshold Behavior of Ultrasound-Induced Lung

    E-Print Network [OSTI]

    Illinois at Urbana-Champaign, University of

    Superthreshold Behavior of Ultrasound-Induced Lung Hemorrhage in Adult Rats Role of Pulse of an earlier ultrasound-induced lung hemorrhage study (Ultrasound Med Biol 2003; 29:1625­1634) that estimated, at least for the lung. Key Words: duty factor; lung hemorrhage; pulsed ultrasound; pulse duration; pulse

  5. Development of a microfluidic device for blood oxygenation by photocatalysis

    E-Print Network [OSTI]

    Ullah, Tania

    2009-01-01T23:59:59.000Z

    Recent statistics provided by the American Lung Association assert that over 400,000 Americans die every year from lung disorders and more than 35 million are now living with symptoms of lung disease. Mortality rates of ...

  6. INTRODUCTION Acute lung injury is characterized by lesions of both lung

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    INTRODUCTION Acute lung injury is characterized by lesions of both lung endothelial and alveolar collagenase (Pardo et al., 1997). The latter was increased following acute lung injury induced by hyperoxia

  7. Bisphosphonate-Associated Osteonecrosis of the Jaw: Report of a Task Force of the American Society for Bone and Mineral Research

    E-Print Network [OSTI]

    Dennett, Daniel

    Editorial Bisphosphonate-Associated Osteonecrosis of the Jaw: Report of a Task Force reports were also reviewed. Results and Conclusions: A case definition was developed so that subsequent studies could report on the same condition. The task force defined ONJ as the presence of exposed bone

  8. Journal of Heredity 2003:94(4):341351 2003 The American Genetic Association DOI: 10.1093/jhered/esg061

    E-Print Network [OSTI]

    Volis, Sergei

    of variation was ambiguous. Although two alleles exhibited a pattern of distribution that cannot be explained examining the association of genetic variation with discrete environmental heterogeneity (soil type, sun.g., rainfall, temperature, or salinity) (Hedrick et al. 1976). This methodology is explicit in tests

  9. Ohio State adds 18 new AAAS fellows Eighteen Ohio State faculty were elected among the newest class of Fellows of the American Association for the

    E-Print Network [OSTI]

    ) to test and expand a university-developed technology that can produce biogas from solid organic wastes and bioenergy crops, such as yard waste, crop residue, and lignocellulosic food waste. The integrated anaerobic digestion system (iADs), a patent-pending technology developed by Yebo Li, associate professor of food

  10. Imaging-Histologic Discordance at Percutaneous Biopsy of the Lung

    E-Print Network [OSTI]

    2015-01-01T23:59:59.000Z

    in small pe- ripheral lung cancers. AJR Am J Roentgenolin reports indicating ‘‘primary lung cancer’’ or ‘‘benignspecified,’’ ‘‘primary lung cancer,’’ or ‘‘metastatic

  11. American Society for Quality Design of Experiments for Comparing Treatments with a Control: Tables of Optimal

    E-Print Network [OSTI]

    Bustamante, Fabián E.

    : Technometrics, Vol. 25, No. 1 (Feb., 1983), pp. 87-95 Published by: American Statistical Association of scholarship. For more information about JSTOR, please contact support@jstor.org. American Statistical Association and American Society for Quality are collaborating with JSTOR to digitize, preserve and extend

  12. 2012 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies, pages 783792, Montreal, Canada, June 3-8, 2012. c 2012 Association for Computational Linguistics

    E-Print Network [OSTI]

    Dredze, Mark

    associations underly- ing corpora. Since the introduction of latent Dirich- let allocation (LDA) (Blei et al, such as adding supervision (Blei and McAuliffe, 2007), non-parametric priors (Blei et al., 2004; Teh et al., 2006), topic correla- tions (Li and McCallum, 2006; Mimno et al., 2007; Blei and Lafferty, 2006) and sparsity

  13. Iron supplementation at high altitudes induces inflammation and oxidative injury to lung tissues in rats

    SciTech Connect (OSTI)

    Salama, Samir A., E-mail: salama.3@buckeyemail.osu.edu [High Altitude Research Center, Taif University, Al-Haweiah, Taif 21974 (Saudi Arabia); Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11751 (Egypt); Department of Pharmacology and GTMR Unit, College of Clinical Pharmacy, Taif University, Al-Haweiah, Taif 21974 (Saudi Arabia); Omar, Hany A. [Department of Pharmacology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514 (Egypt); Maghrabi, Ibrahim A. [Department of Clinical Pharmacy, College of Clinical Pharmacy, Taif University, Al-Haweiah, Taif 21974 (Saudi Arabia); AlSaeed, Mohammed S. [Department of Surgery, College of Medicine, Taif University, Al-Haweiah, Taif 21974 (Saudi Arabia); EL-Tarras, Adel E. [High Altitude Research Center, Taif University, Al-Haweiah, Taif 21974 (Saudi Arabia)

    2014-01-01T23:59:59.000Z

    Exposure to high altitudes is associated with hypoxia and increased vulnerability to oxidative stress. Polycythemia (increased number of circulating erythrocytes) develops to compensate the high altitude associated hypoxia. Iron supplementation is, thus, recommended to meet the demand for the physiological polycythemia. Iron is a major player in redox reactions and may exacerbate the high altitudes-associated oxidative stress. The aim of this study was to explore the potential iron-induced oxidative lung tissue injury in rats at high altitudes (6000 ft above the sea level). Iron supplementation (2 mg elemental iron/kg, once daily for 15 days) induced histopathological changes to lung tissues that include severe congestion, dilatation of the blood vessels, emphysema in the air alveoli, and peribronchial inflammatory cell infiltration. The levels of pro-inflammatory cytokines (IL-1?, IL-6, and TNF-?), lipid peroxidation product and protein carbonyl content in lung tissues were significantly elevated. Moreover, the levels of reduced glutathione and total antioxidant capacity were significantly reduced. Co-administration of trolox, a water soluble vitamin E analog (25 mg/kg, once daily for the last 7 days of iron supplementation), alleviated the lung histological impairments, significantly decreased the pro-inflammatory cytokines, and restored the oxidative stress markers. Together, our findings indicate that iron supplementation at high altitudes induces lung tissue injury in rats. This injury could be mediated through excessive production of reactive oxygen species and induction of inflammatory responses. The study highlights the tissue injury induced by iron supplementation at high altitudes and suggests the co-administration of antioxidants such as trolox as protective measures. - Highlights: • Iron supplementation at high altitudes induced lung histological changes in rats. • Iron induced oxidative stress in lung tissues of rats at high altitudes. • Iron increased the levels of IL-1?, IL-6 and TNF-? in lung tissues at high altitudes. • Trolox alleviated the iron-induced histological and biochemical changes to the lungs.

  14. VOLUME 87, NUMBER 8 P H Y S I C A L R E V I E W L E T T E R S 20 AUGUST 2001 Avalanche Dynamics of Crackle Sound in the Lung

    E-Print Network [OSTI]

    Alencar, Adriano Mesquita

    of Crackle Sound in the Lung Adriano M. Alencar,1,2 Sergey V. Buldyrev,2 Arnab Majumdar,2 H. Eugene Stanley,2, called "crackles," which are associated with explosive openings of airways during lung inflation-field solution of the model which provides information about lung inflation. DOI: 10.1103/PhysRevLett.87

  15. Radiofrequency Ablation of Subpleural Lung Malignancy: Reduced Pain Using an Artificially Created Pneumothorax

    SciTech Connect (OSTI)

    Lee, Edward W., E-mail: EdwardLee@mednet.ucla.edu; Suh, Robert D., E-mail: rsuh@mednet.ucla.ed [David Geffen School of Medicine at UCLA, Department of Radiological Sciences, Thoracic Imaging and Intervention, Center for the Health Sciences (CHS), UCLA Medical Center (United States); Zeidler, Michelle R. [David Geffen School of Medicine at UCLA, Department of Internal Medicine, Pulmonary and Critical Care (United States); Tsai, Irene S. [David Geffen School of Medicine at UCLA, Department of Radiological Sciences, Thoracic Imaging and Intervention, Center for the Health Sciences (CHS), UCLA Medical Center (United States); Cameron, Robert B. [David Geffen School of Medicine at UCLA, Department of Surgery, Thoracic Oncology (United States); Abtin, Fereidoun G.; Goldin, Jonathan G. [David Geffen School of Medicine at UCLA, Department of Radiological Sciences, Thoracic Imaging and Intervention, Center for the Health Sciences (CHS), UCLA Medical Center (United States)

    2009-07-15T23:59:59.000Z

    One of the main issues with radiofrequency (RF) ablation of the subpleural lung malignancy is pain management during and after RF ablation. In this article, we present a case that utilized a technique to decrease the pain associated with RF ablation of a malignancy located within the subpleural lung. Under CT guidance, we created an artificial pneumothorax prior to the RF ablation, which resulted in minimizing the pain usually experienced during and after the procedure. It also decreased the amount of pain medications usually used in patients undergoing RF ablation of a subpleural lung lesion.

  16. Comprehensive molecular profiling of lung adenocarcinoma

    E-Print Network [OSTI]

    Lander, Eric S.

    Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, ...

  17. National Heart, Lung, and Blood Institute

    E-Print Network [OSTI]

    Bandettini, Peter A.

    National Heart, Lung, and Blood Institute A T - A - G L A N C E : Coronary Heart Disease C oronary is available from the National Heart, Lung, and Blood Institute (NHLBI) Web site at www.nhlbi.nih.gov (under

  18. National Heart, Lung, and Blood Institute

    E-Print Network [OSTI]

    Bandettini, Peter A.

    National Heart, Lung, and Blood Institute A T - A - G L A N C E : Atherosclerosis A therosclerosis, Lung, and Blood Institute (NHLBI) Web site at www.nhlbi.nih.gov (under Health Information

  19. National Heart, Lung, and Blood Institute

    E-Print Network [OSTI]

    Bandettini, Peter A.

    National Heart, Lung, and Blood Institute A T - A - G L A N C E : What You Need To Know About High on lowering cholesterol is available from the National Heart, Lung, and Blood Institute (NHLBI) Web site

  20. National Heart, Lung, and Blood Institute

    E-Print Network [OSTI]

    Bandettini, Peter A.

    National Heart, Lung, and Blood Institute A T - A - G L A N C E : Healthy Sleep S leep is not just information on healthy sleep and sleep disorders is available from the National Heart, Lung, and Blood

  1. National Heart, Lung, and Blood Institute

    E-Print Network [OSTI]

    Bandettini, Peter A.

    National Heart, Lung, and Blood Institute A T - A - G L A N C E : Physical Activity and Your Heart benefits. It can strengthen your heart and improve lung func- tion, and it may help prevent certain types

  2. National Heart, Lung, and Blood Institute

    E-Print Network [OSTI]

    Bandettini, Peter A.

    National Heart, Lung, and Blood Institute A T - A - G L A N C E : Facts About Healthy Weight Why indicator of your risk for a variety of diseases. To check your BMI, use the National Heart, Lung, and Blood

  3. Survival after bilateral lung transplantation versus single lung transplantation for patients with chronic obstructive pulmonary disease.

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Survival after bilateral lung transplantation versus single lung transplantation for patients, Pennsylvania, USA. 8 International Heart and Lung Transplant Registry, Addison, Texas. Word count: 3204 Background: Both single and bilateral lung transplantation (LT) are recognized options for patients with end

  4. What Lung Cancer Patients Need to Know

    E-Print Network [OSTI]

    Kaski, Samuel

    What Lung Cancer Patients Need to Know About Bone Health A Publication of The Bone and Cancer Foundation #12;Contents THIS PUBLICATION PROVIDES IMPORTANT INFORMATION ABOUT THE RELATIONSHIP BETWEEN LUNG CANCER AND BONE HEALTH. HOW BONE WORKS (PAGE 2). WHAT LUNG CANCER CAN DO TO BONE (PAGE 2). TREATING BONE

  5. The branching programme of mouse lung development

    E-Print Network [OSTI]

    Klein, Ophir

    ARTICLES The branching programme of mouse lung development Ross J. Metzger1 {, Ophir D. Klein2 {, Gail R. Martin2 & Mark A. Krasnow1 Mammalian lungs are branched networks containing thousands by three geometrically simple local modes of branching used in three different orders throughout the lung

  6. National Heart, Lung, and Blood Institute

    E-Print Network [OSTI]

    Bandettini, Peter A.

    National Heart, Lung, and Blood Institute A T - A - G L A N C E : Asthma A sthma is a chronic (longterm) lung dis ease that inflames and narrows the air ways. This makes the airways swollen and very, the muscles around them tighten. This causes the airways to nar row, and less air flows to your lungs

  7. Superthreshold Behavior of Ultrasound-Induced Lung

    E-Print Network [OSTI]

    Illinois at Urbana-Champaign, University of

    Superthreshold Behavior of Ultrasound-Induced Lung Hemorrhage in Adult Rats Role of Pulse and reevaluate the ultra- sound-induced lung hemorrhage findings of a previous 5 × 3 factorial design study, 250, and 500 Hz) and exposure duration (ED; 5, 10, and 20 s) on ultrasound-induced lung hemorrhage

  8. Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK

    E-Print Network [OSTI]

    Katayama, Ryohei

    The echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion oncogene represents a molecular target in a small subset of non-small cell lung cancers (NSCLCs). This fusion leads to ...

  9. American Academy of Sleep Medicine American Academy of Sleep Medicine

    E-Print Network [OSTI]

    Goldman, Steven A.

    © American Academy of Sleep Medicine American Academy of Sleep Medicine The following product has been developed by the American Academy of Sleep Medicine Copyright © 2003 American Academy of Sleep: (708) 492-0943 Visit Us at www.aasmnet.org #12;© American Academy of Sleep Medicine American Academy

  10. Laminin ?2 fragments are increased in the circulation of patients with early phase acute lung injury

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    with early phase acute lung injury ing ?uids of patientsepithelial repair in acute lung injury—a translationalmatrix biology in the lung. Am J Physiol Lung Cell Mol

  11. The Cold War and American Education

    E-Print Network [OSTI]

    Marden, David L.

    1975-10-01T23:59:59.000Z

    and Historical Society curator Richard Morgan lost his post be­ cause of his presumed associations with Communists. A bela­ ted American Anthropology Association investigation deter­ mined that the dismissal in no way reflected upon Morgan's professional... competence. The Society's president explained: There are no charges on file against Mr. Morgan affecting his personal or professional, status.... He was not re-elected because his wife and stepson and their Communist associations were involved...

  12. WAYNE STATE UNIVERSITY AMERICAN ASSOCIATION OF

    E-Print Network [OSTI]

    Berdichevsky, Victor

    /No Lockout ..................................................................... 13 Article X: Layoff

  13. QER- Comment of American Gas Association 2

    Broader source: Energy.gov [DOE]

    Attached please find AGA's comments relating to critical issues facing the natural gas distribution industry, which we believe could be usefully addressed in the first phase of the DOE Quadrennial Energy Review (QER). Our comments as submitted here consist of a cover letter and four additional attachments. My colleague Pam Lacey has previously submitted AGA's comments relating to methane emissions under separate cover.

  14. Native American Finance Officers Association Conference

    Broader source: Energy.gov [DOE]

    This event will take place on March 20-21, 2012, in New Orleans, Louisiana. Learn more and register on the NAFOA website.

  15. QER- Comment of American Gas Association 1

    Broader source: Energy.gov [DOE]

    Attached please find AGA's comments on methane emissions issues in the first phase of the DOE Quadrennial Energy Review (QER), consisting of a cover letter and attachments. Dr. Kathryn Clay will be submitting AGA's comments on other aspects of the QER. Please let me know if you have any questions.

  16. QER- Comment of American Gas Association 4

    Broader source: Energy.gov [DOE]

    From: Peterson, Christopher (EIA)Sent: Tuesday, October 14, 2014 12:11 PMTo: Pierpoint, LaraSubject: FW: AGA comments to QER: Natural Gas Emissions Section

  17. QER- Comment of American Gas Association 3

    Broader source: Energy.gov [DOE]

    Dear Ms. Pickett: Attached please find AGA's comments on natural gas vehicle fueling infrastructure as part of our response to the first phase of the DOE Quadrennial Energy Review (QER), consisting of a cover letter and attachments. Respectfully submitted, Kathryn Clay

  18. Terwilliger named American Crystallographic Association Fellow

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del SolStrengthening a solidSynthesis of 2D AlloysTrailsAND RESOLUTIONTerwilliger Named

  19. ORIGINAL PAPER Range expansion and prey use of American mink

    E-Print Network [OSTI]

    Boyer, Edmond

    ORIGINAL PAPER Range expansion and prey use of American mink in Argentinean Patagonia: dilemmas of American mink as an introduced species in Patagonia and elsewhere, together with our own survey, we discuss the implications of this invasion for biodiversity conservation in Argentinean Patagonia and the associated

  20. Thursday, April 10, 2008 A Fuller Picture of Your Lungs

    E-Print Network [OSTI]

    Walsworth, Ronald L.

    Thursday, April 10, 2008 A Fuller Picture of Your Lungs A cheap MRI machine images lung function poor pictures of the lungs, which are full of air, and gives an incomplete picture of lung functions a cheap MRI machine that uses a weak magnetic field to image critical aspects of lung physiology

  1. What can I do with this major? AMERICAN STUDIES

    E-Print Network [OSTI]

    Escher, Christine

    and historical sites Historical associations and societies Cultural heritage organizations Historical projects Historical homes Special collections Historical societies Natural history museums Living history museums Art grant writing, budgeting, and legal is- sues surrounding historical artifacts. #12;(American Studies

  2. Anderson-Cook named American Society for Quality Fellow

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Anderson-Cook has worked at LANL since 2004. She also is a Fellow of the American Statistical Association and in 2011 was one of 20 women in New Mexico who received a Governor's...

  3. american psychiatric publishing: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of this guideline, may be available in the Psychiatric Practice section of the APA web site at www.psych.org. 1 Copyright 2013, American Psychiatric Association. APA makes...

  4. Comprehensive genomic characterization of squamous cell lung cancers

    E-Print Network [OSTI]

    Lander, Eric S.

    Lung squamous cell carcinoma is a common type of lung cancer, causing approximately 400,000 deaths per year worldwide. Genomic alterations in squamous cell lung cancers have not been comprehensively characterized, and no ...

  5. Multigenerational epigenetic effects of nicotine on lung function

    E-Print Network [OSTI]

    Leslie, Frances M

    2013-01-01T23:59:59.000Z

    effects of nicotine on lung function. BMC Medicine 2013 11:homeostasis, and repair of the lung. PPAR Res 2012, 8.effects of nicotine on lung function Frances M Leslie

  6. Bleb Point: Mimicker of Pneumothorax in Bullous Lung Disease

    E-Print Network [OSTI]

    Gelabert, Christopher; Nelson, Mathew

    2015-01-01T23:59:59.000Z

    G, Biderman P, et al. “The lung point”: an REFERENCESof cystic and bullous lung disease. Chest Surg Clin N Am.S, Kaiser LR. Giant bullous lung disease: chest radiography

  7. Characterization of Lung's Emphysema Distribution: Numerical Assessment of Disease Development

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Characterization of Lung's Emphysema Distribution: Numerical Assessment of Disease Development M, Egypt. Abstract--Chronic Obstructive Pulmonary Disease (COPD) refers to a group of lung diseases bronchitis. Pulmonary emphysema is defined as a lung disease characterized by "abnormal enlargement

  8. Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing

    E-Print Network [OSTI]

    Lander, Eric S.

    Lung adenocarcinoma, the most common subtype of non-small cell lung cancer, is responsible for more than 500,000 deaths per year worldwide. Here, we report exome and genome sequences of 183 lung adenocarcinoma tumor/normal ...

  9. Associate at the American Planning Association. Planning for Solar Energy

    E-Print Network [OSTI]

    This Pas; Quicknotes Erin Musiol

    There is a growing desire among communities to become more sustainable. Energy conservation and renewable energy production (including solar energy) play a significant role in community sustainability goals. Public officials and engaged citizens have many opportunities throughout the planning process to help support and advance solar energy initiatives in their communities. LONG-RANGE COMMUNITY VISIONING AND GOAL SETTING Community visioning is often the first step in developing any type of community plan, for establishing new standards, policies, and incentives, for doing development work, and for making public investment decisions. Whether part of a planning process or on its own, visioning is an important first chance to identify new opportunities and priorities—including those related to solar energy. Planners often conduct visioning exercises that produce a community’s long-term goals and objectives. By expressing their views of renewable energy generation during these visioning exercises (including responding to surveys and participating in visioning meetings), citizens enable planners to gauge the level of awareness and importance of solar energy in the community. Planners use this information to develop policies and action items for the community. Once a community agrees upon its long-range goals and objectives, municipal officials should look to them when reviewing development proposals, making budget decisions, and performing other related tasks. Both citizens and public officials should use these visioning meetings to discuss how solar energy is connected to other community goals and values and how solar energy could help achieve other community goals. A PV System installed on a residence. (Photo credit:

  10. High Prevalence of Lung Cancer in a Surgical Cohort of Lung Cancer Patients A Decade After Smoking Cessation

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    AJ, Samet M: Epidemiology of Lung Cancer. Chest 2003, 123:The accumulated evidence on lung cancer and environmentalMR, Fueger JJ, et al: “Lung carcinoma in former smokers”.

  11. QER- Comment of American Hydrogen Northeast, Inc.

    Broader source: Energy.gov [DOE]

    Dear Sir or Madam, Attached please find the Hydrogen Association and the American Hydrogen Northeast,inc's Comments on the first round of QER review. I wish to thank Secretary Moniz and Senator Reed for attending the Providence hearing and providing this opportunity to submit these comments.

  12. allergic lung inflammation: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the air pollutants which damage lungs and are linked to respiratory problems such as asthma. A Low symptoms, inflammation in the lung, exposure to traffic-related air...

  13. Software Architecture Decomposition Using Attributes Chung-Horng Lung

    E-Print Network [OSTI]

    Lung, Chung-Horng

    1 Software Architecture Decomposition Using Attributes Chung-Horng Lung Xia Xu Department and Eppinger [29] in other engineering disciplines. Inspired by Alexander, Andreu [2] and Lung,

  14. Automatic Lung Vessel Segmentation via Stacked Multiscale Feature Learning

    E-Print Network [OSTI]

    Toronto, University of

    Automatic Lung Vessel Segmentation via Stacked Multiscale Feature Learning Ryan Kiros, Karteek We introduce a representation learning approach to segmenting vessels in the lungs. Our algorithm

  15. Parenteral Hydrocarbon Injection and Associated Toxicities: Two Case Reports

    E-Print Network [OSTI]

    Nelson, Michael E.; Nasr, Isam

    2013-01-01T23:59:59.000Z

    Annual Report of the American Association of Poison ControlCenters’ National Poison Data System (NPDS): 29 th AnnualToxikon Consortium, Illinois Poison Control Center, Chicago,

  16. Molecular Markers of Lung Cancer in MAYAK Workers

    SciTech Connect (OSTI)

    Steven A. Belinsky, PhD

    2007-02-15T23:59:59.000Z

    The molecular mechanisms that result in the elevated risk for lung cancer associated with exposure to radiation have not been well characterized. Workers from the MAYAK nuclear enterprise are an ideal cohort in which to study the molecular epidemiology of cancer associated with radiation exposure and to identify the genes targeted for inactivation that in turn affect individual risk for radiation-induced lung cancer. Epidemiology studies of the MAYAK cohort indicate a significantly higher frequency for adenocarcinoma and squamous cell carcinoma (SCC) in workers than in a control population and a strong correlation between these tumor types and plutonium exposure. Two hypotheses will be evaluated through the proposed studies. First, radiation exposure targets specific genes for inactivation by promoter methylation. This hypothesis is supported by our recent studies with the MAYAK population that demonstrated the targeting of the p16 gene for inactivation by promoter methylation in adenocarcinomas from workers (1). Second, genes inactivated in tumors can serve as biomarkers for lung cancer risk in a cancer-free population of workers exposed to plutonium. Support for this hypothesis is based on exciting preliminary results of our nested, case-control study of persons from the Colorado cohort. In that study, a panel of methylation markers for predicting lung cancer risk is being evaluated in sputum samples from incident lung cancer cases and controls. The first hypothesis will be tested by determining the prevalence for promoter hypermethylation of a panel of genes shown to play a critical role in the development of either adenocarcinoma and/or SCC associated with tobacco. Our initial studies on adenocarcinoma in MAYAK workers will be extended to evaluate methylation of the PAX5 {alpha}, PAX5 {beta}, H-cadherin, GATA5, and bone morphogenesis 3B (BMP3B) genes in the original sample set described under Preliminary studies. In addition, studies will be initiated in SCC from workers and controls to identify genes targeted for inactivation by plutonium in this other common histologic form of lung cancer. We will examine methylation of the p16, O{sup 6}-methylguanine-DNA methyl-transferase (MGMT), and death associated protein kinase genes ([DAP-K], evaluated previously in adenocarcinomas) as well as the new genes being assessed in the adenocarcinomas. The second hypothesis will be tested in a cross-sectional study of cancer-free workers exposed to plutonium and an unexposed population. A cohort of 700 cancer-free workers and 700 unexposed persons is being assembled, exposures are being defined, and induced sputum collected at initial entry into the study and approximately 1-year later. Exposed and unexposed persons will be matched by 5-year age intervals and smoking status (current and former). The frequency for methylation of four genes that show the greatest difference in prevalence in tumors from workers and controls will be determined in exfoliated cells within sputum. These studies will extend those in primary tumors to determine whether difference in prevalence for individual or multiple genes are detected in sputum samples from high-risk subjects exposed to plutonium. Follow-up of this cohort offers the opportunity to validate these endpoints and future biomarkers as true markers for lung cancer risk.

  17. This sheet has sample occupations, work settings, employers, and career development activities associated with this major. Some of these options may require additional training and career planning. You are not limited to these options when choosing a poss

    E-Print Network [OSTI]

    Ronquist, Fredrik

    Service Recreational Facilities Research & Consulting Organizations Shipping, Water, & Transport Companies Unlimited. American Academy of Forensic Science - Colorado Springs, CO www.aafs.org American Association

  18. american raptor american: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    K 1998-01-01 163 Socioeconomic Characteristics of American Indians in Los Angeles County University of California eScholarship Repository Summary: American Indians is critical...

  19. AMERICAN ANTHROPOLOGIST Public Anthropology

    E-Print Network [OSTI]

    Illinois at Chicago, University of

    AMERICAN ANTHROPOLOGIST Public Anthropology 2012 Public Anthropology Year in Review: Actually, Rick a torrent of criticism from anthropologists, including an online response by #12;Year in Review: Public

  20. Native American Heritage Month

    Broader source: Energy.gov [DOE]

    This month, we celebrate the rich heritage and myriad contributions of American Indians and Alaska Natives, and we rededicate ourselves to supporting tribal sovereignty, tribal self-determination,...

  1. Precedents in African American architecture

    E-Print Network [OSTI]

    Sass, Lawrence

    1994-01-01T23:59:59.000Z

    As a sub-sets of American culture, African Americans have not been able to offer culturally specific architectural elements to the design process because the history of African American form and space has not been recognized ...

  2. The Insistence Upon Community in the Contemporary Afro-American Novel

    E-Print Network [OSTI]

    Schultz, Elizabeth A.

    1979-01-01T23:59:59.000Z

    ELIZABETH A. SCHULTZ The Insistence Upon Community in the Contemporary Afro-American Novel BIGGER THOMAS WAITS DEFIANTLY AND ALONE for death at the conclusion of Richard Wright's Native Son (1940). The narrator of Ralph Ellison's Invisible Man...). Elizabeth A. Schultz is associate professor of English at the University of Kansas and associate ditor of American Studies. In addition to articles on black American literature and music, Professor Schultz has published several poems, short stories...

  3. Osteoporosis: diagnosis, treatment, and its association with lung disease

    E-Print Network [OSTI]

    Minikel, Michelle L

    2005-01-01T23:59:59.000Z

    osteoporosis have already been identified. Women, especially those who have already gone through menopause

  4. Osteoporosis: diagnosis, treatment, and its association with lung disease

    E-Print Network [OSTI]

    Minikel, Michelle L

    2005-01-01T23:59:59.000Z

    from the National Osteoporosis Risk Assessment. Jama, 2001.4. httpts‘twww.no?org/osteoporosis/diseasefacts.htm. FastFacts. 2004, National Osteoporosis Foundation. 38 10. 11.

  5. Research results on biomagnetic imaging of the lung tumors Laurel O. Silleruda,b

    E-Print Network [OSTI]

    Coutsias, Evangelos

    of the leading causes of cancer-related death in the United States. One of the difficulties associated that the death rate for lung cancer is so high is a reflection of the suboptimal state of current therapeutic of initial diagnosis 5-year cure rates are ~50% 1 . For patients with more-advanced, nonresectable initial

  6. Defect in lung growth* Comparative study of three diagnostic criteria.

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Defect in lung growth* Comparative study of three diagnostic criteria. P. DECHELOTTE, A. LABBE, O and fetuses (49 pathological cases and 25 controls) to detect defects in lung growth. In each case lung disease. RA count is low in lung hypoplasia but is not an entirely reliable diagnostic criterion since

  7. Lung, Artificial: Basic Principles and Current Applications William J. Federspiel

    E-Print Network [OSTI]

    Federspiel, William J.

    Lung, Artificial: Basic Principles and Current Applications William J. Federspiel Kristie A. Henchir University of Pittsburgh, Pittsburgh, Pennsylvania, U.S.A. INTRODUCTION Artificial lungs currently of the lung, which is to oxygenate the blood and remove carbon dioxide. Current artificial lungs are also

  8. GREIT: towards a consensus EIT algorithm for lung images

    E-Print Network [OSTI]

    Adler, Andy

    GREIT: towards a consensus EIT algorithm for lung images Andy Adler1 , John Arnold2 , Richard in the patient's lungs. However, most clinical and physiological research in lung EIT is done using older reconstruction algorithm for lung EIT, called GREIT (Graz consensus Reconstruc- tion algorithm for EIT

  9. Immune Reactions of the Lung in Infection and Allergy

    E-Print Network [OSTI]

    Manstein, Dietmar J.

    Immune Reactions of the Lung in Infection and Allergy ¡ Interactions of microorganisms with cells of the lung ¡ Cells and mediators in immune reactions of the lung Sabine Ehrt, New York, USA Rees Kassen, Hannover Characterization of pulmonary host defense mechanisms in chronic lung disease 10.00 ­ 10.40 Albert

  10. Estimating Volumes of Simulated Lung Cancer Nodules David E. Gilsinn

    E-Print Network [OSTI]

    Gilsinn, David E.

    Estimating Volumes of Simulated Lung Cancer Nodules David E. Gilsinn Bruce R. Borchardt Amelia Tebbe§ July 15, 2009 Abstract Lung cancer is a disease of uncontrolled cell growth in tissues of the lung. Computed to- mography (CT) shows promise in detecting lung cancers at earlier, more operable

  11. Collapsibility of Lung Volume by Paired Inspiratory and Expiratory CT

    E-Print Network [OSTI]

    Collapsibility of Lung Volume by Paired Inspiratory and Expiratory CT Scans: Correlations with Lung Function and Mean Lung Density Tsuneo Yamashiro, MD, Shin Matsuoka, MD, PhD, Brian J. Bartholmai, MD, Rau: To evaluate the relationship between measurements of lung volume (LV) on inspiratory/expiratory computed

  12. NHLBI Workshop Summaries Resident Cellular Components of the Human Lung

    E-Print Network [OSTI]

    Engelhardt, John F.

    NHLBI Workshop Summaries Resident Cellular Components of the Human Lung Current Knowledge and Goals, Maryland; 5 Lung Diseases, National Heart, Lung and Blood Institute, National Institutes of Health and Cell Biology, The University of Iowa, Iowa City, Iowa; 11 Developmental Lung Biology Research

  13. Smithsonian American Art Museum INVENTORIES OF AMERICAN PAINTING AND SCULPTURE

    E-Print Network [OSTI]

    Mathis, Wayne N.

    Smithsonian American Art Museum INVENTORIES OF AMERICAN PAINTING AND SCULPTURE GUIDELINES FOR REPORTING WORKS The INVENTORIES OF AMERICAN PAINTING AND SCULPTURE were created by the Smithsonian American collections around the country. The database for the Inventories references over 360,000 works from two

  14. Lung Cancer . Author manuscript p16INK4A inactivation mechanisms in non-small-cell lung cancer patients

    E-Print Network [OSTI]

    Boyer, Edmond

    Lung Cancer . Author manuscript Page /1 10 p16INK4A inactivation mechanisms in non-small-cell lung occupational risk factor and that asbestos acts synergistically with tobacco smoking to induce lung cancer. Although some somatic gene alterations in lung cancer have been linked to tobacco smoke, few data

  15. The role of uPAR signaling in lung cancer Background and significance

    E-Print Network [OSTI]

    Gleeson, Joseph G.

    The role of uPAR signaling in lung cancer Background and significance Lung cancer is the leading of lung cancer ­ non-small-cell-lung cancer (about 85% of all lung cancer cases) and small- cell-lung cancer (about 15%) (Herbst et al., 2008). Small cell lung carcinoma (SCLC) is rapidly growing and often

  16. New American Home{reg_sign}: Atlanta, Georgia - 2001; Building America--The New American Home

    SciTech Connect (OSTI)

    IBACOS; Anderson, R.

    2001-07-19T23:59:59.000Z

    The New American Home{reg_sign} is an annual showcase project designed by committee and co-sponsored by the National Association of Home Builders' National Council of the Housing Industry, BUILDERS Magazine, and Ladies Home Journal. Hedgewood Properties teamed with Building America's IBACOS Consortium and Southface Energy Institute to build a house with a Home Energy Rating Systems (HERS) level of 90.

  17. White Paper Developed by the American Gas Association and American Public Gas Association

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilA group currentBradley NickellApril 16, 2008 TBD-0075 -In the Matter 1 White

  18. Bitumen fume-induced gene expression profile in rat lung

    SciTech Connect (OSTI)

    Gate, Laurent [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France)]. E-mail: laurent.gate@inrs.fr; Langlais, Cristina [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Micillino, Jean-Claude [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Nunge, Herve [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Bottin, Marie-Claire [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Wrobel, Richard [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Binet, Stephane [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France)

    2006-08-15T23:59:59.000Z

    Exposure to bitumen fumes during paving and roofing activities may represent an occupational health risk. To date, most of the studies performed on the biological effect of asphalt fumes have been done with regard to their content in carcinogenic polycyclic aromatic hydrocarbons (PAH). In order to gain an additional insight into the mechanisms of action of bitumen fumes, we studied their pulmonary effects in rodents following inhalation using the microarray technology. Fisher 344 rats were exposed for 5 days, 6 h/day to bitumen fumes generated at road paving temperature (170 {sup o}C) using a nose-only exposition device. With the intention of studying the early transcriptional events induced by asphalt fumes, lung tissues were collected immediately following exposure and gene expression profiles in control and exposed rats were determined by using oligonucleotide microarrays. Data analysis revealed that genes involved in lung inflammatory response as well as genes associated with PAH metabolization and detoxification were highly expressed in bitumen-exposed animals. In addition, the expression of genes related to elastase activity and its inhibition which are associated with emphysema was also modulated. More interestingly genes coding for monoamine oxidases A and B involved in the metabolism of neurotransmitters and xenobiotics were downregulated in exposed rats. Altogether, these data give additional information concerning the bitumen fumes biological effects and would allow to better review the health effects of occupational asphalt fumes exposure.

  19. Lung Nodule Detection in Screening Computed Tomography

    E-Print Network [OSTI]

    Gori, I; Cerello, P; Cheran, S C; De Nunzio, G; Fantacci, M E; Kasae, P; Masala, G L; Pérez-Martínez, A; Retico, A

    2007-01-01T23:59:59.000Z

    A computer-aided detection (CAD) system for the identification of pulmonary nodules in low-dose multi-detector helical Computed Tomography (CT) images with 1.25 mm slice thickness is presented. The basic modules of our lung-CAD system, a dot-enhancement filter for nodule candidate selection and a neural classifier for false-positive finding reduction, are described. The results obtained on the collected database of lung CT scans are discussed.

  20. The NOD/RIP2 Pathway Is Essential for Host Defenses Against Chlamydophila pneumoniae Lung Infection

    E-Print Network [OSTI]

    2009-01-01T23:59:59.000Z

    bacterial infection of the lung in predisposition/protectionof Pseudomonas aeruginosa in the lung following bone marrowneutrophil recruitment to the lungs. Levels of IL-6 and IFN-

  1. Lung Cancer as a Second Primary Malignancy: Increasing Prevalence and Its Influence on Survival

    E-Print Network [OSTI]

    Quadrelli, Silvia; Lyons, Gustavo; Colt, Henri; Chimondeguy, Domingo; Silva, Carlos

    2009-01-01T23:59:59.000Z

    therapy for multiple primary lung cancers. Chest. REFERENCEMR. Multiple primary lung cancers. J Thorac Cardiovasc Surg.606–12. 2. Johnson BE. Second lung cancers in patients after

  2. THE KINETICS OF REVERSIBLE-SEQUESTRATION OF LEUKOCYTES BY THE ISOLATED PERFUSED RAT LUNG

    E-Print Network [OSTI]

    Goliaei, Bahrain.

    2010-01-01T23:59:59.000Z

    Granulocytes. , c. II. The Lung . . Material and Method .Isolated Perfusion rfused Lung Preparation. , B. C. Single-1954). "Role of Am. J. the Lungs in Regulation of the White

  3. Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    Molecular pathogenesis of lung cancer,” Annual Review ofp63 immunoreac- tivity in lung cancer: yet another player inprotein-related genes in lung cancer: correlation with drug

  4. The effects of PTHrP-mediated ERK activation on non-small cell lung carcinoma

    E-Print Network [OSTI]

    Phun, Jennifer

    2011-01-01T23:59:59.000Z

    knockout mouse shows delayed lung development. Pediatric ResL.J. (1991). All major lung cancer cell types produceregulates apoptosis in lung cancer cells through protein

  5. Unbalanced Data Classification Using Support Vector Machines with Active Learning on Scleroderma Lung Disease Patterns

    E-Print Network [OSTI]

    Lee, Jongyoon

    2013-01-01T23:59:59.000Z

    Scleroderma Lung Study (SLS) . . . . . . . . . . . . .vi List of Figures CT scans of Normal Lung (NL), Lung Fibrosis (LF), and Honeycomb (HC) . Denoised

  6. Effects of combined hyperoxia and cyclooxygenase inhibition in neonatal rat lungs

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    K. Effect of indomethacin on lung development in postnatalinhibition & neonatal rat lungs the fetal ductus arteriosus.expression in human lungs of newborns with congenital

  7. Aerosol Deposition in Healthy and Emphysematous Rat Lungs : : Insights From MRI Measurements and Computational Simulations

    E-Print Network [OSTI]

    Oakes, Jessica M.

    1.1 Lung Physiology . . . . . . . . . . . . . .Particle Concentration Calibration . . . 4.2.6 Lung Particle1.2 Particle Deposition in the Lung . . . . . . . . 1.3

  8. Latin American Theatre Review, Volume 06, Number 2: Front Matter

    E-Print Network [OSTI]

    1973-04-01T23:59:59.000Z

    LATIN AMERICAN THEATRE REVIEW a Journal devoted to the Theatre and Drama of Spanish and Portuguese America Editor (il.OR(,l. W. WoODYARI) Associate Editor JOHN S. BRIMIWOOD Assistant Editors WILLIAM R. BLUL RAYMOND D. SOUZA Ml... are available at $4.00 each. Please direct all correspondence to: Lditors, Latin Amernan Theatre Renew. The Center of Latin American Studies, The University of Kansas, Lawrence, Kansas 66U-H. 6/2 LATIN AMERICAN THEATRE REVIEW SPRING1973 Contents Esa luna...

  9. The great American garage

    E-Print Network [OSTI]

    Miller, B. Alex (Brian Alex), 1977-

    2004-01-01T23:59:59.000Z

    How does one explore the suburban home? Go in through the garage, of course. Sales, bands, suicides, and business startups: The suburban garage is the most culturally flexible space in the entire American domestic environment. ...

  10. Asian American women entrepreneurs

    E-Print Network [OSTI]

    Suh, Clara J

    2014-01-01T23:59:59.000Z

    There are an estimated 620,300 firms owned by Asian American women nationwide, and they contribute $105 billion to the U.S. economy. They are also active in Greater Boston's innovation and entrepreneurship communities. ...

  11. Radiation-induced lung injury

    SciTech Connect (OSTI)

    Rosiello, R.A.; Merrill, W.W. (Yale Univ. Medical Center, New Haven, CT (USA))

    1990-03-01T23:59:59.000Z

    The use of radiation therapy is limited by the occurrence of the potentially fatal clinical syndromes of radiation pneumonitis and fibrosis. Radiation pneumonitis usually becomes clinically apparent from 2 to 6 months after completion of radiation therapy. It is characterized by fever, cough, dyspnea, and alveolar infiltrates on chest roentgenogram and may be difficult to differentiate from infection or recurrent malignancy. The pathogenesis is uncertain, but appears to involve both direct lung tissue toxicity and an inflammatory response. The syndrome may resolve spontaneously or may progress to respiratory failure. Corticosteroids may be effective therapy if started early in the course of the disease. The time course for the development of radiation fibrosis is later than that for radiation pneumonitis. It is usually present by 1 year following irradiation, but may not become clinically apparent until 2 years after radiation therapy. It is characterized by the insidious onset of dyspnea on exertion. It most often is mild, but can progress to chronic respiratory failure. There is no known successful treatment for this condition. 51 references.

  12. Survival after Radiofrequency Ablation in 122 Patients with Inoperable Colorectal Lung Metastases

    SciTech Connect (OSTI)

    Gillams, Alice, E-mail: alliesorting@gmail.com [The London Clinic, Radiology Department (United Kingdom); Khan, Zahid [Countess of Chester Hospital (United Kingdom); Osborn, Peter [Queen Alexandra Hospital (United Kingdom); Lees, William [University College London Medical School (United Kingdom)

    2013-06-15T23:59:59.000Z

    Purpose. To analyze the factors associated with favorable survival in patients with inoperable colorectal lung metastases treated with percutaneous image-guided radiofrequency ablation. Methods. Between 2002 and 2011, a total of 398 metastases were ablated in 122 patients (87 male, median age 68 years, range 29-90 years) at 256 procedures. Percutaneous CT-guided cool-tip radiofrequency ablation was performed under sedation/general anesthesia. Maximum tumor size, number of tumors ablated, number of procedures, concurrent/prior liver ablation, previous liver or lung resection, systemic chemotherapy, disease-free interval from primary resection to lung metastasis, and survival from first ablation were recorded prospectively. Kaplan-Meier analysis was performed, and factors were compared by log rank test. Results. The initial number of metastases ablated was 2.3 (range 1-8); the total number was 3.3 (range 1-15). The maximum tumor diameter was 1.7 (range 0.5-4) cm, and the number of procedures was 2 (range 1-10). The major complication rate was 3.9 %. Overall median and 3-year survival rate were 41 months and 57 %. Survival was better in patients with smaller tumors-a median of 51 months, with 3-year survival of 64 % for tumors 2 cm or smaller versus 31 months and 44 % for tumors 2.1-4 cm (p = 0.08). The number of metastases ablated and whether the tumors were unilateral or bilateral did not affect survival. The presence of treated liver metastases, systemic chemotherapy, or prior lung resection did not affect survival. Conclusion. Three-year survival of 57 % in patients with inoperable colorectal lung metastases is better than would be expected with chemotherapy alone. Patients with inoperable but small-volume colorectal lung metastases should be referred for ablation.

  13. RESEARCH Open Access Cellular transcriptional profiling in human lung

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    RESEARCH Open Access Cellular transcriptional profiling in human lung epithelial cells infected expression profiles of human lung A549 cells infected by five different subtypes of human and avian influenza

  14. Differentiation of normal and cancerous lung tissues by multiphoton imaging

    E-Print Network [OSTI]

    Wang, Chun-Chin

    We utilize multiphoton microscopy for the label-free diagnosis of noncancerous, lung adenocarcinoma (LAC), and lung squamous cell carcinoma (SCC) tissues from humans. Our results show that the combination of second-harmonic ...

  15. NF-?B Fans the Flames of Lung Carcinogenesis

    E-Print Network [OSTI]

    Jacks, Tyler E.

    This perspective on Deng et al. (beginning on p. 424 in this issue of the journal) examines the link between NF-?B and lung tumorigenesis. Experiments in genetically engineered mouse models of lung cancers are elucidating ...

  16. CENTER FOR ENVIRONMENTAL MEDICINE, ASTHMA AND LUNG BIOLOGY PUBLICATIONS (2008)

    E-Print Network [OSTI]

    Crews, Stephen

    2008-01-01T23:59:59.000Z

    CENTER FOR ENVIRONMENTAL MEDICINE, ASTHMA AND LUNG BIOLOGY PUBLICATIONS (2008) Alexis NE, Muhlebach MS, Peden DB, Noah TL. Attenuation of host defense function of lung phagocytes in early cystic

  17. ORIGINAL RESEARCH Chung-Horng Lung Joseph E. Urban

    E-Print Network [OSTI]

    Lung, Chung-Horng

    ORIGINAL RESEARCH Chung-Horng Lung Æ Joseph E. Urban Gerald T. Mackulak Analogy-based domain problem that shares significant aspects with the past problem and C.-H. Lung (&) Department of Systems

  18. Andrew Case "American Environmental History"

    E-Print Network [OSTI]

    Wisconsin at Madison, University of

    Andrew Case History "American Environmental History" Spring 2008 Advisor: William Cronon Classics, Richard. "It's Your Misfortune and None of My Own": A New History of the American West. (Norman

  19. Polarized Helium to Image the Lung

    E-Print Network [OSTI]

    Leduc, M; Leduc, Mich\\`{e}le; Nacher, Pierre-Jean

    2006-01-01T23:59:59.000Z

    The main findings of the european PHIL project (Polarised Helium to Image the Lung) are reported. State of the art optical pumping techniques for polarising ^3He gas are described. MRI methodological improvements allow dynamical ventilation images with a good resolution, ultimately limited by gas diffusion. Diffusion imaging appears as a robust method of lung diagnosis. A discussion of the potential advantage of low field MRI is presented. Selected PHIL results for emphysema are given, with the perspectives that this joint work opens up for the future of respiratory medicine.

  20. of October 2002 African Americans

    E-Print Network [OSTI]

    Kammen, Daniel M.

    the impact of air pollution from coal-fired power plants upon the African American community. The Black

  1. Contribution of Gular Pumping to Lung Ventilation in Monitor

    E-Print Network [OSTI]

    Brainerd, Elizabeth

    Contribution of Gular Pumping to Lung Ventilation in Monitor Lizards Tomasz Owerkowicz,1 * Colleen that lizards are subject to a speed- dependent axial constraint that prevents effective lung ventilation during locomotion, varanids use a positive pressure gular pump to assist lung ventilation. Disabling the gular pump

  2. THE MECHANICS OF LUNG TISSUE UNDER HIGH-FREQUENCY VENTILATION

    E-Print Network [OSTI]

    Lewis, Mark

    THE MECHANICS OF LUNG TISSUE UNDER HIGH-FREQUENCY VENTILATION MARKUS R. OWEN AND MARK A. LEWIS SIAM­1761 Abstract. High-frequency ventilation is a radical departure from conventional lung ventilation question concerns ventilator-induced damage to the lung tissue, and a clear protocol for the most effective

  3. THE MECHANICS OF LUNG TISSUE UNDER HIGH-FREQUENCY VENTILATION

    E-Print Network [OSTI]

    THE MECHANICS OF LUNG TISSUE UNDER HIGH-FREQUENCY VENTILATION MARKUS R. OWEN AND MARK A. LEWIS Abstract. High frequency ventilation is a radical departure from conventional lung ventilation question concerns ventilator induced damage to the lung tissue, and a clear protocol for the most effective

  4. Changes in Model Lung Surfactant Monolayers Induced by Palmitic Acid

    E-Print Network [OSTI]

    Zasadzinski, Joseph A.

    Changes in Model Lung Surfactant Monolayers Induced by Palmitic Acid Frank Bringezu, Junqi Ding of model lung surfactant lipid monolayers. Adding increasing fractions of palmitic acid (PA) to a 77/23 (wt to the rational design of replacement lung surfactants for the treatment of respiratory distress syndrome

  5. ccsd00004040, Polarized Helium to Image the Lung

    E-Print Network [OSTI]

    ccsd­00004040, version 1 ­ 24 Jan 2005 Polarized Helium to Image the Lung Mich#18;ele Leduc the Lung) are reported. State of the art optical pumping techniques for polarising 3 He gas are described limited by gas di#11;usion. Di#11;usion imaging appears as a robust method of lung diagnosis. A discussion

  6. Tomographic Digital Subtraction Angiography for Lung Perfusion Estimation in Rodents

    E-Print Network [OSTI]

    Tomographic Digital Subtraction Angiography for Lung Perfusion Estimation in Rodents Cristian T. The capabilities of TDSA are established in studies on lung perfusion in rats. Using an imaging system developed in to therapeutics. Keywords X-ray; digital subtraction angiography; tomosynthesis; small animal; lung; perfusion

  7. Biomaterials 28 (2007) 31313139 Towards improved artificial lungs through biocatalysis

    E-Print Network [OSTI]

    Federspiel, William J.

    2007-01-01T23:59:59.000Z

    Biomaterials 28 (2007) 3131­3139 Towards improved artificial lungs through biocatalysis Joel L in the development of artificial lungs and respiratory assist devices, which use hollow fiber membranes (HFMs intervention involves the use of mechan- ical ventilators to provide breathing support while the lungs recover

  8. Visualization of Density Variation in Lung Aristofanes C. Silva

    E-Print Network [OSTI]

    Endler, Markus

    Visualization of Density Variation in Lung Nodules Arist´ofanes C. Silva e-mail: ari-Rio Inf.MCC09/02 June, 2002 Abstract We propose a method for visualize lung nodule, in order to emphasize, limiar. #12;1 Introduction Lung cancer is known to be the form of cancer with the smallest survival rate

  9. The Comprehensive Imaging-Based Analysis of the Lung

    E-Print Network [OSTI]

    Virginia Tech

    The Comprehensive Imaging-Based Analysis of the Lung: A Forum for Team Science1 Eric A. Hoffman, Ph description and understanding of the human lung and its response to disease, injury, and treatment, which for the need to volumetrically im- age the lung and to provide objective, quantitative measures characterizing

  10. Lung, Artificial: Current Research and Future Directions William J. Federspiel

    E-Print Network [OSTI]

    Federspiel, William J.

    Lung, Artificial: Current Research and Future Directions William J. Federspiel Robert G. Svitek University of Pittsburgh, Pittsburgh, Pennsylvania, U.S.A. INTRODUCTION Artificial lungs are medical devices designed to take over or supplement the respiratory function of the lung: oxygenating the blood

  11. Measurement of Regional Lung Function in Rats Using Hyperpolarized 3

    E-Print Network [OSTI]

    Measurement of Regional Lung Function in Rats Using Hyperpolarized 3 Helium Dynamic MRI Ben T. Chen,* Anja C.S. Brau, and G. Allan Johnson Dynamic regional lung function was investigated in rats using by a constant flow ventila- tor. Based on regional differences in the behavior of inspired air, the lung

  12. ORIGINAL ARTICLE Effect of Different Sitting Postures on Lung Capacity,

    E-Print Network [OSTI]

    Makhsous, Mohsen

    ORIGINAL ARTICLE Effect of Different Sitting Postures on Lung Capacity, Expiratory Flow, and Lumbar, Makhsous M. Effect of different sitting postures on lung capacity, expiratory flow, and lumbar lordosis. Arch Phys Med Rehabil 2006;87:504-9. Objective: To investigate the effect of sitting posture on lung

  13. VARIATIONAL APPROACH FOR SEGMENTATION OF LUNG NODULES Amal A. Faraga

    E-Print Network [OSTI]

    Louisville, University of

    VARIATIONAL APPROACH FOR SEGMENTATION OF LUNG NODULES Amal A. Faraga , Hossam Abdelmunimab , James, Louisville, Kentucky g University of Louisville, Department of Radiology ABSTRACT Lung nodules from low dose CT (LDCT) scans may be used for early detection of lung cancer. However, these nodules vary in size

  14. Asymmetries in Electrical Impedance Tomography Lung Images Bartlomiej Grychtol1

    E-Print Network [OSTI]

    Adler, Andy

    Asymmetries in Electrical Impedance Tomography Lung Images Bartlomiej Grychtol1 and Andy Adler2 1, it has been used to image the thorax, to monitor the movement of blood and gas in the heart and lungs. One key application of EIT is to determine the distribution of ventilation within the lungs

  15. Cell Stem Cell Generation of Multipotent Lung and Airway

    E-Print Network [OSTI]

    Mootha, Vamsi K.

    Cell Stem Cell Article Generation of Multipotent Lung and Airway Progenitors from Mouse ESCs.01.018 SUMMARY Deriving lung progenitors from patient-specific pluripotent cells is a key step in producing differenti- ated lung epithelium for disease modeling and trans- plantation. By mimicking the signaling

  16. Predicting Panel Ratings for Semantic Characteristics of Lung Nodules

    E-Print Network [OSTI]

    Schaefer, Marcus

    Predicting Panel Ratings for Semantic Characteristics of Lung Nodules Dmitriy Zinovev De@cdm.depaul.edu ABSTRACT In reading CT scans with potentially malignant lung nodules, radiologists make use of high level a second opinion - predicting these semantic characteristics for lung nodules. In our previous work, we

  17. NHLBI Workshop Future Directions in Early Cystic Fibrosis Lung

    E-Print Network [OSTI]

    Engelhardt, John F.

    NHLBI Workshop Future Directions in Early Cystic Fibrosis Lung Disease Research An NHLBI Workshop of Washington School of Medicine, Seattle, Washington; 3 National Heart, Lung, and Blood Institute, National substantial progress toward under- standing the molecular basis for CF lung disease, leading to the discovery

  18. Computational Model for Forced Expiration from Asymmetric Normal Lungs

    E-Print Network [OSTI]

    Lutchen, Kenneth

    Computational Model for Forced Expiration from Asymmetric Normal Lungs ADAM G. POLAK 1 losses along the airway branches. Calculations done for succeeding lung volumes result in the semidynamic to the choke points, characteristic differences of lung regional pressures and volumes, and a shape

  19. Special Article Elucidating Nature's Solutions to Heart, Lung, and Blood

    E-Print Network [OSTI]

    Storz, Jay F.

    Special Article Elucidating Nature's Solutions to Heart, Lung, and Blood Diseases and Sleep defenses, and oxygen transport. In 2006, the National Heart, Lung, and Blood Institute released a funding understanding of nature's solutions to heart, lung, blood, and sleep disorders through future research

  20. Identification of Early Interstitial Lung Disease in Smokers from the

    E-Print Network [OSTI]

    Identification of Early Interstitial Lung Disease in Smokers from the COPDGene Study George R interstitial lung disease (ILD) on chest computed tomographic (CT) scans. Materials and Methods: The CT scans: Early interstitial lung disease; CT scan; smoker. ªAUR, 2010 I diopathic pulmonary fibrosis (IPF

  1. Computerised lung sound analysis to improve the specificity of paediatric

    E-Print Network [OSTI]

    Elhilali, Mounya

    Computerised lung sound analysis to improve the specificity of paediatric pneumonia diagnosis that pulmonary pathology can be differentiated from normal using computerised lung sound analysis (CLSA). The authors will record lung sounds from 600 children aged #5 years, 100 each with consolidative pneumonia

  2. Lung Cancer and Arsenic Concentrations in Drinking Water in Chile

    E-Print Network [OSTI]

    California at Berkeley, University of

    Lung Cancer and Arsenic Concentrations in Drinking Water in Chile Catterina Ferreccio,1,2 Claudia- trations have since been reduced to 40 g/liter. We investi- gated the relation between lung cancer and arsenic in drinking water in northern Chile in a case-control study involving patients diagnosed with lung

  3. Evaluation of Plasma Resistant Hollow Fiber Membranes For Artificial Lungs

    E-Print Network [OSTI]

    Federspiel, William J.

    Evaluation of Plasma Resistant Hollow Fiber Membranes For Artificial Lungs HEIDE J. EASH,* HEATHER in artificial lungs (ox- ygenators) undergo plasma leakage (or wetting) in which blood plasma slowly fills2 gas permeance of a plasma resistant fiber imposes the greatest constraint upon artificial lung

  4. Lung Disease in Pediatrics: is it all in the Genes?

    E-Print Network [OSTI]

    Lung Disease in Pediatrics: is it all in the Genes? Jay K. Kolls, M.D.Jay K. Kolls, M.D. Chair with CF do worse than other? #12;· Outcomes are better at CF centers · There is huge variation in lung with the same mutation do worse than others? · Modifier genes ­ lung disease ­ Tgfb1 ­ Irfd1 ­ neutrophil

  5. Diversity of gene expression in adenocarcinoma of the lung

    E-Print Network [OSTI]

    Botstein, David

    Diversity of gene expression in adenocarcinoma of the lung Mitchell E. Garber*, Olga G. Troyanskaya Contributed by David Botstein, September 21, 2001 The global gene expression profiles for 67 human lung tumors pathologic analysis. Four main histologic subtypes of lung cancer are regularly distinguished by tumor

  6. Dynamic Lung Morphology of Methacholine-Induced Heterogeneous Bronchoconstriction

    E-Print Network [OSTI]

    Dynamic Lung Morphology of Methacholine-Induced Heterogeneous Bronchoconstriction Ben T. Chen and G). The method provides direct visualization of the venti- lated regions within the lung. Heterogeneous bronchoconstric- tion following the i.v. MCh injection was evident using this technique. These 3 He dynamic lung

  7. EIT measurement of heart and lung perfusion Helga Ross1

    E-Print Network [OSTI]

    Adler, Andy

    EIT measurement of heart and lung perfusion Helga Ross1 , Benjamin J.W. Chow2 , and Andy Adler1 1. Introduction Electrical Impedance Tomography (EIT) shows promise for monitoring a patient's heart and lungs matching in the lungs. The goal of this research is to determine the accuracy of EIT measurements of blood

  8. Cardiopulmonary Function in RatsWith Lung Hemorrhage

    E-Print Network [OSTI]

    Illinois at Urbana-Champaign, University of

    Cardiopulmonary Function in RatsWith Lung Hemorrhage Induced by Pulsed Ultrasound Exposure Jeffery using superthreshold exposure conditions known to produce sig- nificant lung hemorrhage. Methods. In 1 in the left lung of each rat. In a second group of 6 rats, 5 foci of ultrasound-induced hemorrhage were

  9. a bStomach Lung cell zone Clara cell

    E-Print Network [OSTI]

    Krasnow, Mark A.

    a bStomach Lung Chief-cell zone Stem-cell zone Mucus- cell zone Clara cell Tracheal airway Basal independent studies show that, if push comes to shove, differentiated cells of the stomach and lung can act and the other by Stange et al.2 published in Cell, find that followingdepletionofstemcellsinthestomach or lung

  10. -Glutamyl transferase deficiency results in lung oxidant stress in normoxia

    E-Print Network [OSTI]

    Marc, Robert E.

    -Glutamyl transferase deficiency results in lung oxidant stress in normoxia JYH CHANG JEAN,1 YUE E. Marc, Elizabeth Klings, and Martin Joyce-Brady. -Glutamyl transferase deficiency results in lung oxidant stress in normoxia. Am J Physiol Lung Cell Mol Physiol 283: L766­L776, 2002. First published May 3

  11. RESEARCH ARTICLE Open Access Occupational exposure to asbestos and lung

    E-Print Network [OSTI]

    Boyer, Edmond

    RESEARCH ARTICLE Open Access Occupational exposure to asbestos and lung cancer in men: evidence consistently demonstrated that workplace exposure to it increases the risk of developing lung cancer. Few of lung cancer, and 2,053 controls recruited from 8 Canadian provinces between 1994 and 1997. Self

  12. Early Recognition of Lung's Air Sacs Wall Collapsing

    E-Print Network [OSTI]

    Boyer, Edmond

    Early Recognition of Lung's Air Sacs Wall Collapsing M. EMAM, J-F RENAUD de la Faverie, N. GHARBI discusses the possibility of applying a non- liner analysis approach on air density distribution within lung airways tree at any level of branching1. Computed Tomography (CT) 2 source images of the lung

  13. INVESTIGATION The Lsktm1 Locus Modulates Lung and Skin

    E-Print Network [OSTI]

    Broman, Karl W.

    INVESTIGATION The Lsktm1 Locus Modulates Lung and Skin Tumorigenesis in the Mouse Antonella Galvan to both skin and lung tumorigenesis over the susceptibility of the SWR/J strain. In an effort to map tumor.93) and lung (LOD score = 8.74) tumorigenesis. Two genes, Igfbp5 and Igfbp2, residing in this locus

  14. Original article Lentivirus-induced interstitial lung disease

    E-Print Network [OSTI]

    Boyer, Edmond

    Original article Lentivirus-induced interstitial lung disease: pulmonary pathology in sheep a chronic disease in sheep affecting, among other organs, the lungs. Interstitial pneumonitis is similar the pathological features of lungs of sheep naturally infected with visna-maedi virus with the results obtained

  15. Latin American and Caribbean Studies

    E-Print Network [OSTI]

    Saldin, Dilano

    Latin American and Caribbean Studies Certificate About Us UWM graduates in the 21st century American and Caribbean Studies Certificate Program (LACS) will be especially well-prepared for careers academic focus in Latin American and Caribbean languages, histories, and cultures. However, the LACS

  16. Poor Baseline Pulmonary Function May Not Increase the Risk of Radiation-Induced Lung Toxicity

    SciTech Connect (OSTI)

    Wang, Jingbo [Department of Radiation Oncology, University of Michigan/Ann Arbor Veterans Health System, Ann Arbor, Michigan (United States) [Department of Radiation Oncology, University of Michigan/Ann Arbor Veterans Health System, Ann Arbor, Michigan (United States); Department of Radiation Oncology, Cancer Hospital, Chinese Academic Medical Sciences and Peking Union Medical College, Beijing (China); Cao, Jianzhong [Department of Radiation Oncology, Cancer Hospital, Chinese Academic Medical Sciences and Peking Union Medical College, Beijing (China)] [Department of Radiation Oncology, Cancer Hospital, Chinese Academic Medical Sciences and Peking Union Medical College, Beijing (China); Yuan, Shuanghu [Department of Radiation Oncology, University of Michigan/Ann Arbor Veterans Health System, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan/Ann Arbor Veterans Health System, Ann Arbor, Michigan (United States); Ji, Wei [Department of Radiation Oncology, Cancer Hospital, Chinese Academic Medical Sciences and Peking Union Medical College, Beijing (China)] [Department of Radiation Oncology, Cancer Hospital, Chinese Academic Medical Sciences and Peking Union Medical College, Beijing (China); Arenberg, Douglas [Department of Internal Medicine, University of Michigan/Ann Arbor Veterans Health System, Ann Arbor, Michigan (United States)] [Department of Internal Medicine, University of Michigan/Ann Arbor Veterans Health System, Ann Arbor, Michigan (United States); Dai, Jianrong [Department of Radiation Oncology, Cancer Hospital, Chinese Academic Medical Sciences and Peking Union Medical College, Beijing (China)] [Department of Radiation Oncology, Cancer Hospital, Chinese Academic Medical Sciences and Peking Union Medical College, Beijing (China); Stanton, Paul; Tatro, Daniel; Ten Haken, Randall K. [Department of Radiation Oncology, University of Michigan/Ann Arbor Veterans Health System, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan/Ann Arbor Veterans Health System, Ann Arbor, Michigan (United States); Wang, Luhua, E-mail: wlhwq@yahoo.com [Department of Radiation Oncology, Cancer Hospital, Chinese Academic Medical Sciences and Peking Union Medical College, Beijing (China)] [Department of Radiation Oncology, Cancer Hospital, Chinese Academic Medical Sciences and Peking Union Medical College, Beijing (China); Kong, Feng-Ming, E-mail: fengkong@med.umich.edu [Department of Radiation Oncology, University of Michigan/Ann Arbor Veterans Health System, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan/Ann Arbor Veterans Health System, Ann Arbor, Michigan (United States)

    2013-03-01T23:59:59.000Z

    Purpose: Poor pulmonary function (PF) is often considered a contraindication to definitive radiation therapy for lung cancer. This study investigated whether baseline PF was associated with radiation-induced lung toxicity (RILT) in patients with non-small cell lung cancer (NSCLC) receiving conformal radiation therapy (CRT). Methods and Materials: NSCLC patients treated with CRT and tested for PF at baseline were eligible. Baseline predicted values of forced expiratory volume in 1 sec (FEV1), forced vital capacity (FVC), and diffusion capacity of lung for carbon monoxide (DLCO) were analyzed. Additional factors included age, gender, smoking status, Karnofsky performance status, coexisting chronic obstructive pulmonary disease (COPD), tumor location, histology, concurrent chemotherapy, radiation dose, and mean lung dose (MLD) were evaluated for RILT. The primary endpoint was symptomatic RILT (SRILT), including grade ?2 radiation pneumonitis and fibrosis. Results: There was a total of 260 patients, and SRILT occurred in 58 (22.3%) of them. Mean FEV1 values for SRILT and non-SRILT patients were 71.7% and 65.9% (P=.077). Under univariate analysis, risk of SRILT increased with MLD (P=.008), the absence of COPD (P=.047), and FEV1 (P=.077). Age (65 split) and MLD were significantly associated with SRILT in multivariate analysis. The addition of FEV1 and age with the MLD-based model slightly improved the predictability of SRILT (area under curve from 0.63-0.70, P=.088). Conclusions: Poor baseline PF does not increase the risk of SRILT, and combining FEV1, age, and MLD may improve the predictive ability.

  17. Fireclimate interactions in the American West since 1400 CE Valerie Trouet,1

    E-Print Network [OSTI]

    Stephens, Scott L.

    Trouet,1 Alan H. Taylor,2 Eugene R. Wahl,3 Carl N. Skinner,4 and Scott L. Stephens5 Received 6 November in the American West that needs to be accounted for in fire models. Citation: Trouet, V., A. H. Taylor, E. R. Wahl of the American West are generally associated with drought [Heyerdahl et al., 2002; Swetnam, 1993; Taylor et al

  18. A Case Report of 20 Lung Radiofrequency Ablation Sessions for 50 Lung Metastases from Parathyroid Carcinoma Causing Hyperparathyroidism

    SciTech Connect (OSTI)

    Tochio, Maki, E-mail: m-tochio@clin.medic.mie-u.ac.jp; Takaki, Haruyuki; Yamakado, Koichiro; Uraki, Junji; Kashima, Masataka; Nakatsuka, Atsuhiro [Mie University School of Medicine, Department of Radiology (Japan); Takao, Motoshi; Shimamoto, Akira; Tarukawa, Tomohito; Shimpo, Hideto [Mie University School of Medicine, Department of Thoracic and Cardiovascular Surgery (Japan); Takeda, Kan [Mie University School of Medicine, Department of Radiology (Japan)

    2010-06-15T23:59:59.000Z

    A 47-year-old man presented with multiple lung metastases from parathyroid carcinoma that caused hyperparathyroidism and refractory hypercalcemia. Lung radiofrequency (RF) ablation was repeated to decrease the serum calcium and parathyroid hormone levels and improve general fatigue. Pulmonary resection was combined for lung hilum metastases. The patient is still alive 4 years after the initial RF session. He has received 20 RF sessions for 50 lung metastases during this period.

  19. Mouse models of lung cancer : understanding the molecular and cellular basis of lung tumorigenesis

    E-Print Network [OSTI]

    Jackson, Erica L. (Erica Lynn), 1973-

    2003-01-01T23:59:59.000Z

    Lung cancer is the leading cause of cancer deaths worldwide. Patients are typically diagnosed with advanced disease and have a high fatality:case ratio. Despite its prevalence, the identity of the cell of origin, precursor ...

  20. Am J Physiol Lung Cell Mol Physiol . Author manuscript Defective angiogenesis in hypoplastic human fetal lungs correlates with

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Am J Physiol Lung Cell Mol Physiol . Author manuscript Page /1 12 Defective angiogenesis in hypoplastic human fetal lungs correlates with nitric oxide synthase deficiency that occurs despite enhanced.bourbon@inserm.fr > Abstract Lung hypoplasia (LH) is a life-threatening congenital abnormality with various causes. It involves

  1. Differential Expression of Cyclic Nucleotide Phosphodiesterases 4 in Developing Rat Lung Running Title: PDE4 in developing rat lung

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Differential Expression of Cyclic Nucleotide Phosphodiesterases 4 in Developing Rat Lung Running Title: PDE4 in developing rat lung Emmanuel Lopez 1,2,3,4 , Pierre-Henri Jarreau 1,2,3,4 , Elodie Zana 1 Dynamics 239, 9 (2010) 2470-8" DOI : 10.1002/dvdy.22374 #12;2 Abstract During the perinatal period, lungs

  2. Influence of Manufacturing Processes on the Performance of Phantom Lungs

    SciTech Connect (OSTI)

    Traub, Richard J.

    2008-10-01T23:59:59.000Z

    Chest counting is an important tool for estimating the radiation dose to individuals who have inhaled radioactive materials. Chest counting systems are calibrated by counting the activity in the lungs of phantoms where the activity in the phantom lungs is known. In the United States a commonly used calibration phantom was developed at the Lawrence Livermore National Laboratory and is referred to as the Livermore Torso Phantom. An important feature of this phantom is that the phantom lungs can be interchanged so that the counting system can be challenged by different combinations of radionuclides and activity. Phantom lungs are made from lung tissue substitutes whose constituents are foaming plastics and various adjuvants selected to make the lung tissue substitute similar to normal healthy lung tissue. Some of the properties of phantom lungs cannot be readily controlled by phantom lung manufacturers. Some, such as density, are a complex function of the manufacturing process, while others, such as elemental composition of the bulk plastic are controlled by the plastics manufacturer without input, or knowledge of the phantom manufacturer. Despite the fact that some of these items cannot be controlled, they can be measured and accounted for. This report describes how manufacturing processes can influence the performance of phantom lungs. It is proposed that a metric that describes the brightness of the lung be employed by the phantom lung manufacturer to determine how well the phantom lung approximates the characteristics of a human lung. For many purposes, the linear attenuation of the lung tissue substitute is an appropriate surrogate for the brightness.

  3. Small RNA combination therapy for lung cancer

    E-Print Network [OSTI]

    Tammela, Tuomas

    MicroRNAs (miRNAs) and siRNAs have enormous potential as cancer therapeutics, but their effective delivery to most solid tumors has been difficult. Here, we show that a new lung-targeting nanoparticle is capable of delivering ...

  4. Journal Titles American Orthoptic

    E-Print Network [OSTI]

    Sprott, Julien Clinton

    Search Journal Titles American Orthoptic Journal Arctic Anthropology Contemporary Literature Ecological Restoration Journal of Human Resources Land Economics Land Management Pkg Landscape Journal Luso-Brazilian Review Monatshefte Native Plants Journal SubStance Article Copies/Permissions Journal Ebooks Library

  5. This is an un-copyedited author manuscript that was accepted for publication in Hypertension, copyright The American Heart Association. This may not be duplicated or reproduced, other than for personal use or within the "Fair Use of Copyrighted Materials"

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    This is an un-copyedited author manuscript that was accepted for publication in Hypertension author manuscript Hypertension 05/2005; 45(5): 974-9 #12;Abstract Myogenic tone (MT), a fundamental by postural changes, and a rise in the amplitude of MT is associated with hypertension (2) and diabetes

  6. Individual differences in arsenic metabolism and lung cancer in a case-control study in Cordoba, Argentina

    SciTech Connect (OSTI)

    Steinmaus, Craig, E-mail: craigs@berkeley.ed [Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, CA (United States); School of Public Health, University of California, Berkeley, CA (United States); Yuan Yan [School of Public Health, University of California, Berkeley, CA (United States); Kalman, Dave [School of Public Health and Community Medicine, University of Washington, Seattle, WA (United States); Rey, Omar A. [Facultad de Medicina, Universidad Catolica de Cordoba, Cordoba (Argentina); Skibola, Christine F.; Dauphine, Dave; Basu, Anamika; Porter, Kristin E.; Hubbard, Alan; Bates, Michael N.; Smith, Martyn T.; Smith, Allan H. [School of Public Health, University of California, Berkeley, CA (United States)

    2010-09-01T23:59:59.000Z

    In humans, ingested inorganic arsenic is metabolized to monomethylarsenic (MMA) then to dimethylarsenic (DMA), although in most people this process is not complete. Previous studies have identified associations between the proportion of urinary MMA (%MMA) and increased risks of several arsenic-related diseases, although none of these reported on lung cancer. In this study, urinary arsenic metabolites were assessed in 45 lung cancer cases and 75 controls from arsenic-exposed areas in Cordoba, Argentina. Folate has also been linked to arsenic-disease susceptibility, thus an exploratory assessment of associations between single nucleotide polymorphisms in folate metabolizing genes, arsenic methylation, and lung cancer was also conducted. In analyses limited to subjects with metabolite concentrations above detection limits, the mean %MMA was higher in cases than in controls (17.5% versus 14.3%, p = 0.01). The lung cancer odds ratio for subjects with %MMA in the upper tertile compared to those in the lowest tertile was 3.09 (95% CI, 1.08-8.81). Although the study size was too small for a definitive conclusion, there was an indication that lung cancer risks might be highest in those with a high %MMA who also carried cystathionine {beta}-synthase (CBS) rs234709 and rs4920037 variant alleles. This study is the first to report an association between individual differences in arsenic metabolism and lung cancer, a leading cause of arsenic-related mortality. These results add to the increasing body of evidence that variation in arsenic metabolism plays an important role in arsenic-disease susceptibility.

  7. Decreased respiratory system compliance on the sixth day of mechanical ventilation is a predictor of death in patients with established acute lung injury

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    with established acute lung injury. Respiratory Researchof patients with acute lung injury. Predictors of mortality.of mortality in acute lung injury during the era of lung

  8. Working in Indian Country: Building Successful Business Relationships with American Indian Tribes Workshop

    Broader source: Energy.gov [DOE]

    Sponsored by the Association on American Indian Affairs, this one-day conference is for federal, state, and local government officials and business leaders who have a need to develop working relationships with tribes and organizations.

  9. An educator in the landscape : a new identity for American wilderness architecture

    E-Print Network [OSTI]

    Rabitaille, Reilly Paul

    2008-01-01T23:59:59.000Z

    This thesis dispenses with the traditional, now nostalgic, "rustic" style typically associated with the American wilderness, in favor of proposing a new identity - that of Educator in the Landscape. By blending bio-technology ...

  10. Optimum BMI Cut Points to Screen Asian Americans for Type 2 Diabetes

    E-Print Network [OSTI]

    2015-01-01T23:59:59.000Z

    A, Chang HK. A1C and diabetes diagnosis among Filipinoand Native Hawai- ians. Diabetes Care 2010;33:2626–2628 22.RA, et al. ; American Diabetes Association. Impaired fasting

  11. Whole Slide Image Analysis Quantification using Aperio Digital Imaging in a Mouse Lung Metastasis Ronne L. Surface2

    E-Print Network [OSTI]

    Zhou, Yaoqi

    Whole Slide Image Analysis Quantification using Aperio Digital Imaging in a Mouse Lung Metastasis quantitate metastatic mouse lung tumors in a lung section using a H&E stain. Lung sections from a mouse lung of view from each slide representing a whole lung lobe with multiple lung metastases was selected

  12. Arsenic methylation and lung and bladder cancer in a case-control study in northern Chile

    SciTech Connect (OSTI)

    Melak, Dawit [Global Health Sciences, University of California, San Francisco, San Francisco, CA (United States); Ferreccio, Catterina [Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago (Chile); Kalman, David [School of Public Health and Community Medicine, University of Washington, Seattle, WA (United States); Parra, Roxana [Hospital Regional de Antofagasta, Antofagasta (Chile); Acevedo, Johanna; Pérez, Liliana; Cortés, Sandra [Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago (Chile); Smith, Allan H.; Yuan, Yan; Liaw, Jane [Arsenic Health Effects Research Group, School of Public Health, University of California, Berkeley, Berkeley, CA (United States); Steinmaus, Craig, E-mail: craigs@berkeley.edu [Arsenic Health Effects Research Group, School of Public Health, University of California, Berkeley, Berkeley, CA (United States); Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, CA (United States)

    2014-01-15T23:59:59.000Z

    In humans, ingested inorganic arsenic is metabolized to monomethylarsenic (MMA) then to dimethylarsenic (DMA), although this process is not complete in most people. The trivalent form of MMA is highly toxic in vitro and previous studies have identified associations between the proportion of urinary arsenic as MMA (%MMA) and several arsenic-related diseases. To date, however, relatively little is known about its role in lung cancer, the most common cause of arsenic-related death, or about its impacts on people drinking water with lower arsenic concentrations (e.g., < 200 ?g/L). In this study, urinary arsenic metabolites were measured in 94 lung and 117 bladder cancer cases and 347 population-based controls from areas in northern Chile with a wide range of drinking water arsenic concentrations. Lung cancer odds ratios adjusted for age, sex, and smoking by increasing tertiles of %MMA were 1.00, 1.91 (95% confidence interval (CI), 0.99–3.67), and 3.26 (1.76–6.04) (p-trend < 0.001). Corresponding odds ratios for bladder cancer were 1.00, 1.81 (1.06–3.11), and 2.02 (1.15–3.54) (p-trend < 0.001). In analyses confined to subjects only with arsenic water concentrations < 200 ?g/L (median = 60 ?g/L), lung and bladder cancer odds ratios for subjects in the upper tertile of %MMA compared to subjects in the lower two tertiles were 2.48 (1.08–5.68) and 2.37 (1.01–5.57), respectively. Overall, these findings provide evidence that inter-individual differences in arsenic metabolism may be an important risk factor for arsenic-related lung cancer, and may play a role in cancer risks among people exposed to relatively low arsenic water concentrations. - Highlights: • Urine arsenic metabolites were measured in cancer cases and controls from Chile. • Higher urine %MMA values were associated with increased lung and bladder cancer. • %MMA-cancer associations were seen at drinking water arsenic levels < 200 ?g/L.

  13. 86 BYU 20072008 Undergraduate Catalog American Heritage

    E-Print Network [OSTI]

    Hart, Gus

    86 BYU 2007­2008 Undergraduate Catalog American Heritage American Heritage 100. American Heritage, and patterns of historical development. American Studies American Studies Office 4095 JFSB Kerry Soper; literary criticism; historical research; and social, political, and economic analysis. The program provides

  14. Effects of a superoxide dismutase mimetic on biomarkers of lung angiogenesis and alveolarization during hyperoxia with intermittent hypoxia

    E-Print Network [OSTI]

    Chang, Michael; Bany-Mohammed, Fayez; Kenney, M Cristina; Beharry, Kay D

    2013-01-01T23:59:59.000Z

    Dif- ferential responses in the lungs of newborn mouse pupsdismutase protein in the lungs of patients with respiratoryventilation exposes the lungs of ELGANs to oxidative stress

  15. Phenotypic Plasticity in the Lungs of Deer Mice (Peromyscus maniculatus) at High Altitude and the Relationship With Aerobic Performance

    E-Print Network [OSTI]

    Shirkey, Nicholas Joseph

    2013-01-01T23:59:59.000Z

    Induced Mitogenic Factor in Lung With Vasoconstrictive andin growing dogs enhances lung diffusing capacity for oxygenJ. and Banchero, N. (1980). Lung morphometry in guinea pigs

  16. The site of action of PTHrP's proliferative inhibition in non-small cell lung carcinoma

    E-Print Network [OSTI]

    Vander Werff, Ryan Peter

    2010-01-01T23:59:59.000Z

    hormone-related protein in lung cancer cell survival, Chesttreat human non-small cell lung carcinoma through inhibitingthe Growth of Orthotopic Human Lung Tumors in Athymic Mice

  17. Characterization of Lung Tissues using Liquid-Crystal Tunable Filter and Hyperspectral Imaging System

    E-Print Network [OSTI]

    Won, Chang-Hee

    Characterization of Lung Tissues using Liquid-Crystal Tunable Filter and Hyperspectral Imaging to characterize lung tissue for detecting emphysematous tissues in lung volume reduction surgery. The system, the spectral signature of healthy lung tissue and simulated smokers lung tissue is obtained and compared

  18. Lung EIT: Should we reconstruct resistivity or conductivity? Bartlomiej Grychtol1

    E-Print Network [OSTI]

    Adler, Andy

    Lung EIT: Should we reconstruct resistivity or conductivity? Bartlomiej Grychtol1 , Andy Adler2 1.grychtol@dkfz.de MOTIVATION: In lung EIT, the quantity of interest is the change in regional air volume in the lungs. However. The model contains two non-conductive objects that represent the lungs. Assuming that lung resistivity

  19. New American Home 2009 (Brochure)

    SciTech Connect (OSTI)

    Not Available

    2008-12-01T23:59:59.000Z

    This brochure details the New American Home 2009, which demonstrates the use of innovative building materials, cutting-edge design, and the latest construction techniques.

  20. Leonard Wood and the American Empire 

    E-Print Network [OSTI]

    Pruitt, James Herman

    2012-07-16T23:59:59.000Z

    During the ten years following the Spanish American War (1898 to 1908), Major General Leonard Wood served as the primary agent of American imperialism. Wood was not only a proconsul of the new American Empire; he was a ...

  1. RESEARCHARTICLE Copyright 2009 American Scientific Publishers

    E-Print Network [OSTI]

    Frey, Pascal

    to the lungs is extremely difficult, mainly due to their low inertia, and for this reason they are often loaded, and require little or no coordination of actuation and inhalation.2 Local delivery of medication to the lungs mechanisms before reaching the deep lung. It is generally accepted that the size of par- ticles targeted

  2. Methods for testing interactions, with applications to occupational exposures, smoking, and lung cancer

    SciTech Connect (OSTI)

    Thomas, D.C.; Whittemore, A.S.

    1988-01-01T23:59:59.000Z

    Various approaches to assessing the interaction between smoking and occupational exposures are described. The definition of interaction depends on the measure of association under consideration and can be expressed in terms of disease risk, time, or dose. Simple descriptive methods and maximum likelihood model fitting methods are presented for analyzing interactions in terms of joint effects on disease risk. Methods for assessing the influence of exposures on times to disease, using appropriate denominators, are also described. The various approaches are illustrated with published data on lung cancer in relation to asbestos, radon daughters, chloromethyl ethers, and arsenic. Some of the mechanisms that can be invoked to explain the observed patterns include initiation and promotion, lung clearance, transport across cell membranes, and mucous secretion.

  3. Method and apparatus for measuring lung density by Compton backscattering

    DOE Patents [OSTI]

    Loo, Billy W. (Oakland, CA); Goulding, Frederick S. (Lafayette, CA)

    1991-01-01T23:59:59.000Z

    The density of the lung of a patient suffering from pulmonary edema is monitored by irradiating the lung by a single collimated beam of monochromatic photons and measuring the energies of photons Compton backscattered from the lung by a single high-resolution, high-purity germanium detector. A compact system geometry and a unique data extraction scheme are utilized to monimize systematic errors due to the presence of the chestwall and multiple scattering.

  4. Method and apparatus for measuring lung density by Compton backscattering

    DOE Patents [OSTI]

    Loo, B.W.; Goulding, F.S.

    1988-03-11T23:59:59.000Z

    The density of the lung of a patient suffering from pulmonary edema is monitored by irradiating the lung by a single collimated beam of monochromatic photons and measuring the energies of photons compton back-scattered from the lung by a single high-resolution, high-purity germanium detector. A compact system geometry and a unique data extraction scheme are utilized to minimize systematic errors due to the presence of the chestwall and multiple scattering. 11 figs., 1 tab.

  5. A System for Open-Access 3 He Human Lung

    E-Print Network [OSTI]

    Walsworth, Ronald L.

    A System for Open-Access 3 He Human Lung Imaging at Very Low Field I.C. RUSET,1 L.L. TSAI,2,3 R describe a prototype system built to allow open-access very-low-field MRI of human lungs using laser images of human lungs. We include discussion on challenges unique to imaging at 50­200 kHz, including

  6. Weatherization Formula Grants - American Recovery and Reinvestment...

    Energy Savers [EERE]

    Weatherization Formula Grants - American Recovery and Reinvestment Act (ARRA) Weatherization Formula Grants - American Recovery and Reinvestment Act (ARRA) U.S. Department of...

  7. Energy Innovation: Green Button Initiative Empowering Americans...

    Energy Savers [EERE]

    Energy Innovation: Green Button Initiative Empowering Americans to Save Energy and Money Energy Innovation: Green Button Initiative Empowering Americans to Save Energy and Money...

  8. Toward A Quantitative Understanding of Gas Exchange in the Lung

    E-Print Network [OSTI]

    Chang, Yulin V

    2010-01-01T23:59:59.000Z

    In this work we present a mathematical framework that quantifies the gas-exchange processes in the lung. The theory is based on the solution of the one-dimensional diffusion equation on a simplified model of lung septum. Gases dissolved into different compartments of the lung are all treated separately with physiologically important parameters. The model can be applied in magnetic resonance of hyperpolarized xenon for quantification of lung parameters such as surface-to-volume ratio and the air-blood barrier thickness. In general this model provides a description of a broad range of biological exchange processes that are driven by diffusion.

  9. Metabolomics in Lung Inflammation: A High Resolution H NMR Study...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Exposed to Silica Dust . Abstract: First ¹H NMR metabolomics studies on excised lungs and bronchoalveolar lavage fluids (BALF) from mice exposed to crystalline silica are...

  10. abscessus lung disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in patient health by reducing ventilator induced lung injury (VILI) 1 . To protect against VILI, many novel modes Adler, Andy 31 Fibroblast growth factor 10 and...

  11. asthma lung function: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Junfeng Guo; Kalman Palagyi; Kenneth C. Beck; Geoffrey Mclennan 38 Effet of Combined Nitrogen Dioxide and Carbon Nanoparticle Exposure on Lung Function During Computer...

  12. Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

    E-Print Network [OSTI]

    Karsli-Uzunbas, Gizem

    Macroautophagy (autophagy hereafter) recycles intracellular components to sustain mitochondrial metabolism that promotes the growth, stress tolerance, and malignancy of lung cancers, suggesting that autophagy inhibition ...

  13. Bruce Walcheck: Role of neutrophils in acute lung injury, bacterial lung infection, and sepsis (cell based assays and in vivo studies in mice).

    E-Print Network [OSTI]

    Blanchette, Robert A.

    Bruce Walcheck: Role of neutrophils in acute lung injury, bacterial lung infection, and sepsis, eosinophils, and macrophages in the ( ) oapplie lungs (cell based assays and in vivo studies in mice) Alice). Mike Murtaugh: Pathogenesis of lung inflammation during bacterial and viral pneumonia (cell based

  14. Cell Cycle Related Differentiation of Bone Marrow Cells into Lung Cells

    E-Print Network [OSTI]

    Aliotta, Jason M.

    2008-01-01T23:59:59.000Z

    mice can be detected in the lungs of transplanted mice andto 5.43% of cells within the lung are GFP CD45 , which weIn nonirradiated mice, homing to the lung was significantly

  15. THE KINETICS OF REVERSIBLE-SEQUESTRATION OF LEUKOCYTES BY THE ISOLATED PERFUSED RAT LUNG

    E-Print Network [OSTI]

    Goliaei, Bahrain.

    2010-01-01T23:59:59.000Z

    Granulocytes. , c. II. The Lung . . Material and Method . A.1954). "Role of Am. J. the Lungs in Regulation of the WhiteJ. R. ; eds. (1977). of the Lung. Marcel Dekker, Inc. , New

  16. Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis

    E-Print Network [OSTI]

    2004-01-01T23:59:59.000Z

    fibrocytes traffic to the lungs in response to CXCL12 andto CXCL12 and traffics to the lungs in a murine model of+ fibrocytes also traffic to the lungs in response to a

  17. Phenotypic Plasticity of the Lung Surfactant System at High Altitude in Deer Mice, Peromyscus maniculatus

    E-Print Network [OSTI]

    Diaz, Sonia

    2012-01-01T23:59:59.000Z

    Surfactant System. In The Lung: Development, Aging and theJr. and Martin, T. R. (1988). The lung at high altitude:Alveolar dimensions in the lungs of animals raised at high

  18. Laminin ?2 fragments are increased in the circulation of patients with early phase acute lung injury

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    Extracellular matrix biology in the lung. Am J Physiol Lungstep in restoring the lung to its normal architecture [2,was inserted into the lungs. The bronchial micro-sampling

  19. Chlamydia pneumoniae Infection in Mice Induces Chronic Lung Inflammation, iBALT Formation, and Fibrosis

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    lymphoid aggregates in the lungs To determine the kineticslocal host defence in the lung. The Journal of pathologyterm chronic changes in the lungs. We infected C57BL/6 mice

  20. Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    of lung cancer,” Clinical Cancer Research, vol. 4, no. 7,pathogenesis of lung cancer,” Annual Review of Physiology,immunoreac- tivity in lung cancer: yet another player in the

  1. Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    as: Ware et al. : Biomarkers of lung epithelial injury andN, Ware LB: Biomarkers in acute lung injury–marking forwardMA, May AK, Ware LB: Acute lung injury in patients with

  2. The NOD/RIP2 Pathway Is Essential for Host Defenses Against Chlamydophila pneumoniae Lung Infection

    E-Print Network [OSTI]

    2009-01-01T23:59:59.000Z

    production in Rip2 2/2 mice. Lung tissues of WT and Rip2 2/21610 6 IFU). After 5 days, lungs were collected and thebacterial counts in lung tissue homogenates were

  3. Cell Cycle Related Differentiation of Bone Marrow Cells into Lung Cells

    E-Print Network [OSTI]

    Aliotta, Jason M.

    2008-01-01T23:59:59.000Z

    Bone marrow production of lung cells: the impact of G-CSF,bone marrow to reconstitute lung epithelium. Am. J. Respirof Bone Marrow Cells into Lung Cells Mark S. Dooner 1 *,

  4. Lung tumor tracking, trajectory reconstruction, and motion artifact removal using rotational cone-beam projections

    E-Print Network [OSTI]

    Lewis, John Henry

    2010-01-01T23:59:59.000Z

    breast and prostate cancer are more common than lung cancer,but lung cancer causes the most deaths. Courtesy of theSB Jiang, Markerless lung tumor tracking and trajectory

  5. The ultrastructure of book lung development in the bark scorpion Centruroides gracilis (Scorpiones: Buthidae)

    E-Print Network [OSTI]

    Farley, Roger D

    2011-01-01T23:59:59.000Z

    channels of adult book lungs in scorpions and spiders [to the relationship of the lung-book of Scorpio to the gill-of scorpions. 5. The lungs. Q J Microsc Sci 1926, 70:135-

  6. Phenotypic Plasticity of the Lung Surfactant System at High Altitude in Deer Mice, Peromyscus maniculatus

    E-Print Network [OSTI]

    Diaz, Sonia

    2012-01-01T23:59:59.000Z

    edema. Characteristics of lung lavage fluid. JAMA 256, 63-9.in cultured ATII cells and lung fibroblasts. Am J Physiolof oxygen effects on lung tissue. AMRL-TR-66-120. AMRL TR,

  7. Physiological and Computed Tomographic Predictors of Outcome from Lung Volume Reduction Surgery

    E-Print Network [OSTI]

    Physiological and Computed Tomographic Predictors of Outcome from Lung Volume Reduction Surgery: Previous investigations have identified several potential predictors of outcomes from lung volume reduction: To identify objective radiographic and physiological indices of lung disease that have prognostic value

  8. Lung Extraction, Lobe Segmentation and Hierarchical Region Assessment for Quantitative Analysis on High

    E-Print Network [OSTI]

    Lung Extraction, Lobe Segmentation and Hierarchical Region Assessment for Quantitative Analysis Care Division, Brigham and Women's Hospital, Boston, MA Abstract. Regional assessment of lung disease specific to different lung regions on high resolution computed tomography (HRCT) datasets. We present

  9. Sex-specific differences in hyperoxic lung injury in mice: Implications for acute and chronic lung disease in humans

    SciTech Connect (OSTI)

    Lingappan, Krithika, E-mail: lingappa@bcm.edu [Department of Pediatrics, Section of Neonatology, Texas Children's Hospital, Baylor College of Medicine, 1102 Bates Avenue, MC: FC530.01, Houston, TX 77030 (United States); Jiang, Weiwu; Wang, Lihua; Couroucli, Xanthi I. [Department of Pediatrics, Section of Neonatology, Texas Children's Hospital, Baylor College of Medicine, 1102 Bates Avenue, MC: FC530.01, Houston, TX 77030 (United States); Barrios, Roberto [Department of Pathology and Genomic Medicine, The Methodist Hospital Physician Organization, 6565 Fannin Street, Suite M227, Houston, TX 77030 (United States); Moorthy, Bhagavatula [Department of Pediatrics, Section of Neonatology, Texas Children's Hospital, Baylor College of Medicine, 1102 Bates Avenue, MC: FC530.01, Houston, TX 77030 (United States)

    2013-10-15T23:59:59.000Z

    Sex-specific differences in pulmonary morbidity in humans are well documented. Hyperoxia contributes to lung injury in experimental animals and humans. The mechanisms responsible for sex differences in the susceptibility towards hyperoxic lung injury remain largely unknown. In this investigation, we tested the hypothesis that mice will display sex-specific differences in hyperoxic lung injury. Eight week-old male and female mice (C57BL/6J) were exposed to 72 h of hyperoxia (FiO{sub 2} > 0.95). After exposure to hyperoxia, lung injury, levels of 8-iso-prostaglandin F{sub 2} alpha (8-iso-PGF 2?) (LC–MS/MS), apoptosis (TUNEL) and inflammatory markers (suspension bead array) were determined. Cytochrome P450 (CYP)1A expression in the lung was assessed using immunohistochemistry and western blotting. After exposure to hyperoxia, males showed greater lung injury, neutrophil infiltration and apoptosis, compared to air-breathing controls than females. Pulmonary 8-iso-PGF 2? levels were higher in males than females after hyperoxia exposure. Sexually dimorphic increases in levels of IL-6 (F > M) and VEGF (M > F) in the lungs were also observed. CYP1A1 expression in the lung was higher in female mice compared to males under hyperoxic conditions. Overall, our results support the hypothesis that male mice are more susceptible than females to hyperoxic lung injury and that differences in inflammatory and oxidative stress markers contribute to these sex-specific dimorphic effects. In conclusion, this paper describes the establishment of an animal model that shows sex differences in hyperoxic lung injury in a temporal manner and thus has important implications for lung diseases mediated by hyperoxia in humans. - Highlights: • Male mice were more susceptible to hyperoxic lung injury than females. • Sex differences in inflammatory markers were observed. • CYP1A expression was higher in females after hyperoxia exposure.

  10. The American Recovery

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently AskedEnergyIssuesEnergy Solar Decathlon2001 Power PlantAPRIL 1, 2011TheAmerican

  11. American Physical Society awards

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office511041cloth DocumentationProductsAlternative FuelsSanta Fe MetroWeinbergAmerican Physical Society

  12. American Venture Acceleration Fund

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office511041cloth DocumentationProductsAlternative FuelsSanta Fe MetroWeinbergAmericanSix regional

  13. American Physical Society Fellows

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625govInstrumentstdmadapInactiveVisiting the TWP TWPAlumni Alumni PARC/I-CARES CERTIFICATE INofNuclear SocietyAmerican

  14. Comments of the Southern Environmental Law Center and the American Lung

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011AT&T, Inc.'sEnergyTexas1.Space Data Corporation Comments oftheLowerof

  15. Comments of the Southern Environmental Law Center and the American Lung

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 111 1,613PortsmouthBartlesville EnergyDepartment. CashDay-June 22, 2015PolicyofDepartment

  16. Accelerating Alternatives for Minnesota Drivers

    Broader source: Energy.gov (indexed) [DOE]

    Energy * Xcel Energy Other * American Lung Association in Minnesota * Boyer Ford * Eaton Corporation * Environmental Initiative * PlugInConnect * University of Minnesota -...

  17. Lisa Thurstin

    Broader source: Energy.gov [DOE]

    Lisa Thurstin is the coordinator for the Twin Cities Clean Cities coalition, which is based out of the American Lung Association of the Upper Midwest.

  18. Dose impact in radiographic lung injury following lung SBRT: Statistical analysis and geometric interpretation

    SciTech Connect (OSTI)

    Yu, Victoria; Kishan, Amar U.; Cao, Minsong; Low, Daniel; Lee, Percy; Ruan, Dan, E-mail: druan@mednet.ucla.edu [Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90024 (United States)] [Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90024 (United States)

    2014-03-15T23:59:59.000Z

    Purpose: To demonstrate a new method of evaluating dose response of treatment-induced lung radiographic injury post-SBRT (stereotactic body radiotherapy) treatment and the discovery of bimodal dose behavior within clinically identified injury volumes. Methods: Follow-up CT scans at 3, 6, and 12 months were acquired from 24 patients treated with SBRT for stage-1 primary lung cancers or oligometastic lesions. Injury regions in these scans were propagated to the planning CT coordinates by performing deformable registration of the follow-ups to the planning CTs. A bimodal behavior was repeatedly observed from the probability distribution for dose values within the deformed injury regions. Based on a mixture-Gaussian assumption, an Expectation-Maximization (EM) algorithm was used to obtain characteristic parameters for such distribution. Geometric analysis was performed to interpret such parameters and infer the critical dose level that is potentially inductive of post-SBRT lung injury. Results: The Gaussian mixture obtained from the EM algorithm closely approximates the empirical dose histogram within the injury volume with good consistency. The average Kullback-Leibler divergence values between the empirical differential dose volume histogram and the EM-obtained Gaussian mixture distribution were calculated to be 0.069, 0.063, and 0.092 for the 3, 6, and 12 month follow-up groups, respectively. The lower Gaussian component was located at approximately 70% prescription dose (35 Gy) for all three follow-up time points. The higher Gaussian component, contributed by the dose received by planning target volume, was located at around 107% of the prescription dose. Geometrical analysis suggests the mean of the lower Gaussian component, located at 35 Gy, as a possible indicator for a critical dose that induces lung injury after SBRT. Conclusions: An innovative and improved method for analyzing the correspondence between lung radiographic injury and SBRT treatment dose has been demonstrated. Bimodal behavior was observed in the dose distribution of lung injury after SBRT. Novel statistical and geometrical analysis has shown that the systematically quantified low-dose peak at approximately 35 Gy, or 70% prescription dose, is a good indication of a critical dose for injury. The determined critical dose of 35 Gy resembles the critical dose volume limit of 30 Gy for ipsilateral bronchus in RTOG 0618 and results from previous studies. The authors seek to further extend this improved analysis method to a larger cohort to better understand the interpatient variation in radiographic lung injury dose response post-SBRT.

  19. 3D MRI of Non-Gaussian He Gas Diffusion in the Rat Lung. | EMSL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Results show that the non-Gaussian effects of ³He gas diffusion in healthy rat lungs are directly attributed to the anisotropic geometry of lung microstructure, and that...

  20. Lung Toxicity and Mutagenicity of Emissions From Heavy-Duty Compressed...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Lung Toxicity and Mutagenicity of Emissions From Heavy-Duty Compressed Natural Gas (CNG)-Powered Vehicles Lung Toxicity and Mutagenicity of Emissions From Heavy-Duty Compressed...

  1. A Systematic Analysis of Epigenetic Genes across Different Stages of Lung Adenocarcinoma Akshay Desai1

    E-Print Network [OSTI]

    Zhou, Yaoqi

    A Systematic Analysis of Epigenetic Genes across Different Stages of Lung Adenocarcinoma Akshay across different stages of lung adenocarcinoma (LUAD). Method: An integrative system biology approach

  2. Lung Cancer (2005) 47, 41--47 Improving the specificity of fluorescence

    E-Print Network [OSTI]

    Duin, Robert P.W.

    2005-01-01T23:59:59.000Z

    Lung Cancer (2005) 47, 41--47 Improving the specificity of fluorescence bronchoscopy spectroscopy; Lung cancer; Bronchoscopy Summary Detection of malignancies of the bronchial tree in an early

  3. Investigating the initiation and progression of small cell lung cancer

    E-Print Network [OSTI]

    Brauneis, Alison Dooley

    2011-01-01T23:59:59.000Z

    Small cell lung cancer (SCLC) comprises 18% of all lung cancer cases and is an aggressive disease with a five-year survival rate of less than 5%, mainly due to the advanced nature of the disease at the time of diagnosis. ...

  4. First Floor Smithsonian American Art Museum

    E-Print Network [OSTI]

    Mathis, Wayne N.

    First Floor Smithsonian American Art Museum American Experience Folk Art Special ExhibitionsMillan Education Center Folk Art One Life Archives of American Art Gallery Recent AcquisitionsMuseum Store Museum Museum Graphic Arts American Art through 1940 America's Presidents The Struggle for Justice

  5. Professor, Communication Studies and African American Studies

    E-Print Network [OSTI]

    Miami, University of

    Professor, Communication Studies and African American Studies Director of African American of Communication and Theatre Arts and Director of the African American Studies Program at the University of Puget Book Chapter Award from the African American Communication and Culture Division and the Black Caucus

  6. Lung tissue engineering : in vitro synthesis of lung tissue from neonatal and fetal rat lung cells cultured in a three-dimensional collagen matrix

    E-Print Network [OSTI]

    Chen, Patty P., 1981-

    2004-01-01T23:59:59.000Z

    The focus of this study was to investigate the histology of tissue formed when fetal (16-20 days gestation) and neonatal (2 days old) rat lung cells were grown in a collagen-glycosaminoglycan scaffold. This project employed ...

  7. Serum Amyloid A as a Predictive Marker for Radiation Pneumonitis in Lung Cancer Patients

    SciTech Connect (OSTI)

    Wang, Yu-Shan [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China) [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China); Department of Animal Science, National Ilan University, Ilan, Taiwan (China); Chang, Heng-Jui [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China)] [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China); Chang, Yue-Cune [Department of Mathematics, Tamkang University, Taipei, Taiwan (China)] [Department of Mathematics, Tamkang University, Taipei, Taiwan (China); Huang, Su-Chen; Ko, Hui-Ling; Chang, Chih-Chia [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China)] [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China); Yeh, Yu-Wung; Jiang, Jiunn-Song [Department of Chest Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China)] [Department of Chest Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China); Lee, Cheng-Yen; Chi, Mau-Shin [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China)] [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China); Chi, Kwan-Hwa, E-mail: M006565@ms.skh.org.tw [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China) [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China); Institute of Radiation Science and School of Medicine, National Yang-Ming University, Taipei, Taiwan (China)

    2013-03-01T23:59:59.000Z

    Purpose: To investigate serum markers associated with radiation pneumonitis (RP) grade ?3 in patients with lung cancer who were treated with radiation therapy. Methods and Materials: Pretreatment serum samples from patients with stage Ib-IV lung cancer who developed RP within 1 year after radiation therapy were analyzed to identify a proteome marker able to stratify patients prone to develop severe RP by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS). Dosimetric parameters and 3 biological factors were compared. Results: Serum samples from 16 patients (28%) with severe RP (grade 3-4) and 42 patients (72%) with no or mild RP (grade 0-2) were collected for analysis. All patients received a median of 54 Gy (range, 42-70 Gy) of three-dimensional conformal radiation therapy with a mean lung dose (MLD) of 1502 cGy (range, 700-2794 cGy). An m/z peak of 11,480 Da was identified by SELDI-TOF-MS, and serum amyloid A (SAA) was the primary splitter serum marker. The receiver operating characteristic area under the curve of SAA (0.94; 95% confidence interval [CI], 0.87-1.00) was higher than those of C-reactive protein (0.83; 95% CI, 0.72-0.94), interleukin-6 (0.79; 95% CI, 0.65-0.94), and MLD (0.57; 95% CI, 0.37-0.77). The best sensitivity and specificity of combined SAA and MLD for predicting RP were 88.9% and 96.0%, respectively. Conclusions: Baseline SAA could be used as an auxiliary marker for predicting severe RP. Extreme care should be taken to limit the lung irradiation dose in patients with high SAA.

  8. The effects of neighborhood environments on the level of physical activity among older african american women in Texas 

    E-Print Network [OSTI]

    Shin, Woo Hwa

    2009-05-15T23:59:59.000Z

    The older African American women living Texas fall into one of the most inactive population segments. Recently, the importance of socio-ecological models on human health behavior and more complex associations between ...

  9. Christopher M. Jones Staff Research Associate

    E-Print Network [OSTI]

    Kammen, Daniel M.

    Christopher M. Jones Staff Research Associate Renewable and Appropriate Energy Laboratory ­ 2005 M.S. Energy and Resources, University of California, Berkeley 2002 ­ 2005 M.A. Latin American, Berkeley Berkeley Graduate Student Instructor, Sociology 101 c. Selected Publications 1. Jones, C.M

  10. North American SynchroPhasor Initiative (NASPI) Technical Report...

    Energy Savers [EERE]

    the North American SynchroPhasor Initiative, a collaboration between the North American electric industry (utilities, grid operators, vendors and consultants), the North American...

  11. Society of American Indian Government Employees Annual National Training Program

    Broader source: Energy.gov [DOE]

    Event includes plenary session, American Indian law classes, Native American youth workshops, cultural presentations, and a veterans program. Sponsored by the Society of American Indian Government...

  12. Impact of tumor size and tracer uptake heterogeneity in F-FDG PET and CT NonSmall Cell Lung Cancer

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    heterogeneity on various PET uptake delineation approaches. Methods: 25 NSCLC cancer patients with 18F-FDG PET/CT increasingly used for staging Non-small Cell Lung Cancer (NSCLC) (1). In addition, the use of 18 F-FDG PET/CT F-FDG), associated with Computed Tomography (CT) since the development of PET/CT devices, has been

  13. www.thelancet.com Vol 372 October 25, 2008 1473 Effects of smoking and solid-fuel use on COPD, lung cancer,

    E-Print Network [OSTI]

    Cohen, Ted

    and cooking.2 Tobacco smoking and indoor air pollution from solid-fuel use are the most important global risk an independent risk factor for tuberculosis5­7 and suggested a positive association between indoor air pollution COPD, lung cancer, and tuberculosis will be a ected by trends in smoking and indoor air pollution

  14. Welfare and Conversion: The Catholic Church in African American Communities in the South, 1884-1939

    E-Print Network [OSTI]

    Collopy, William

    2012-02-14T23:59:59.000Z

    : An Investigation of Catholic Activity in Behalf of the Negroes in the United States and a Survey of the Present Condition of the Colored Missions. Gillard dedicated his work, which countless students of the African American apostolate have referenced over...; Associated Archives of St. Mary?s Seminary and University; Archives of the Society of the Divine Word; Archives of the Sisters of the Holy Family; Reginald F. Lewis Museum of Maryland African American History and Culture; Archives of the Congregation...

  15. Geothermal energy for American Samoa

    SciTech Connect (OSTI)

    Not Available

    1980-03-01T23:59:59.000Z

    The geothermal commercialization potential in American Samoa was investigated. With geothermal energy harnessed in American Samoa, a myriad of possibilities would arise. Existing residential and business consumers would benefit from reduced electricity costs. The tuna canneries, demanding about 76% of the island's process heat requirements, may be able to use process heat from a geothermal source. Potential new industries include health spas, aquaculture, wood products, large domestic and transhipment refrigerated warehouses, electric cars, ocean nodule processing, and a hydrogen economy. There are no territorial statutory laws of American Samoa claiming or reserving any special rights (including mineral rights) to the territorial government, or other interests adverse to a land owner, for subsurface content of real property. Technically, an investigation has revealed that American Samoa does possess a geological environment conducive to geothermal energy development. Further studies and test holes are warranted.

  16. energy company opens American branch

    E-Print Network [OSTI]

    Lin, C.-Y. Cynthia

    in clean-energy investment and delivering unique projects and innovative products and servicesenergy company opens American branch in West Sacramento Substainible energy for sustainable energy supply. Ecostream markets such things as solar roof panel installations and other long

  17. Effect of Two Models of Intrauterine Growth Restriction on Alveolarization in Rat Lungs: Morphometric and Gene

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Effect of Two Models of Intrauterine Growth Restriction on Alveolarization in Rat Lungs L-NAME impairs lung development before alveolarization. Known growth factors involved in lung on Alveolarization in Rat Lungs: Morphometric and Gene Expression Analysis. PLoS ONE 8(11): e78326. doi:10

  18. TP53 gene mutations of lung cancer patients in upper northern Thailand and environmental risk factors

    E-Print Network [OSTI]

    TP53 gene mutations of lung cancer patients in upper northern Thailand and environmental risk mutations are observed in about 40e70% of lung cancer tissues, and the hot spot codon mu- tations factors that influence TP53 gene mutation in lung cancer patients residing areas with high lung cancer

  19. Mesenchymal Nuclear factor I B regulates cell proliferation and epithelial differentiation during lung maturation

    E-Print Network [OSTI]

    Gronostajski, Richard M.

    lung maturation Yu-Chih Hsu a , Jason Osinski a , Christine E. Campbell a , E. David Litwack b , Dan 2011 Accepted 6 April 2011 Available online 13 April 2011 Keywords: NFI-B Lung development Mesenchymal is expressed in both lung mesenchyme and epithelium and mice lacking Nfib have severe lung maturation defects

  20. Automatic Lung Nodule Detection from Chest CT Data Using Geometrical Features: Initial Results

    E-Print Network [OSTI]

    Whelan, Paul F.

    Automatic Lung Nodule Detection from Chest CT Data Using Geometrical Features: Initial Results for automatic lung nodule detection from Chest CT data is proposed. The proposed system includes the methods of lung segmentation and nodule detection from CT data. The algorithm for lung segmentation consists

  1. Homogenization of a Multiscale Viscoelastic Model with Nonlocal Damping, Application to the Human Lungs

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Lungs PAUL CAZEAUX, Laboratoire J.­L. Lions, UMR 7598, Université Pierre et Marie Curie-Paris 6, 4 Place of the deformation of the human lung tissue, called the lung parenchyma, during the respiration process bronchi and enters the lungs. It is then distributed by the bronchial tree to the acini or alveolar

  2. He Lung Imaging in an Open Access, Very-Low-Field Human Magnetic Resonance Imaging System

    E-Print Network [OSTI]

    Walsworth, Ronald L.

    3 He Lung Imaging in an Open Access, Very-Low-Field Human Magnetic Resonance Imaging System R. W. Butler,6 F. W. Hersman,4 and R. L. Walsworth1 The human lung and its functions are extremely sensitive lung restrict sub- jects to lying horizontally. Imaging of human lungs using inhaled laser-polarized 3

  3. Ultrasound-induced lung hemorrhage: Role of acoustic boundary conditions at the pleural surface

    E-Print Network [OSTI]

    Illinois at Urbana-Champaign, University of

    Ultrasound-induced lung hemorrhage: Role of acoustic boundary conditions at the pleural surface intercostal tissue and lung was evaluated as a possible explanation for the enhanced lung damage the volume of air inspired and expired. The acoustic impedance difference between intercostal tissue and lung

  4. Impedance measurements of ex vivo rat lung at different volumes of inflation

    E-Print Network [OSTI]

    Illinois at Urbana-Champaign, University of

    Impedance measurements of ex vivo rat lung at different volumes of inflation Michael L. Oelze that the occurrence of ultrasonically induced lung hemorrhage in rats was directly correlated to the level of lung inflation. In that study, it was hypothesized that the lung could be modeled as two components consisting

  5. Elastin protein levels are a vital modifier affecting normal lung development and susceptibility to emphysema

    E-Print Network [OSTI]

    Mecham, Robert

    Elastin protein levels are a vital modifier affecting normal lung development and susceptibility modifier affecting normal lung development and susceptibility to emphysema. Am J Physiol Lung Cell Mol-induced emphysema is highly variable, and numerous genetic and environmental factors are thought to mitigate lung

  6. NEURAL PCA NETWORK FOR LUNG OUTLINE RECONSTRUCTION IN VQ SCAN IMAGES

    E-Print Network [OSTI]

    Serpen, Gursel

    NEURAL PCA NETWORK FOR LUNG OUTLINE RECONSTRUCTION IN VQ SCAN IMAGES G. Serpen1 , Ph. D., R. Iyer1 system takes the digitized ventilation-perfusion scan images of lungs as input, identify a template according to the size and shape of the lungs and thereby approximate and reconstruct the outline of the lung

  7. Evaluation of a Pumping Assist Lung That Uses a Rotating Fiber Bundle

    E-Print Network [OSTI]

    Federspiel, William J.

    Evaluation of a Pumping Assist Lung That Uses a Rotating Fiber Bundle ROBERT G. SVITEK,* BRIAN J. FRANKOWSKI,* AND WILLIAM J. FEDERSPIEL,*§ A paracorporeal respiratory assist lung (PRAL) is being devel- oped for supplemental gas exchange to allow the native lungs of acute lung failure patients to heal. The device consists

  8. Differential regulation of RANTES and IL-8 expression in lung adenocarcinoma cells

    E-Print Network [OSTI]

    Boyer, Edmond

    1 Differential regulation of RANTES and IL-8 expression in lung adenocarcinoma cells Corinne expression in lung adenocarcinoma cells HALauthormanuscriptinserm-00143972,version1 HAL author manuscript Lung Cancer 56, 2 (2007) 167-74 #12;2 Summary In lung adenocarcinoma, expression of Regulated upon

  9. Synthetic Lung Tumor Data Sets for Comparison of Volumetric Algorithms1

    E-Print Network [OSTI]

    Bernal, Javier

    Synthetic Lung Tumor Data Sets for Comparison of Volumetric Algorithms1 Adele P. Peskin of synthetic lung tumor data in which synthetic tumors of known volume are embedded in clinical lung computerized tomographic (CT) data in different background settings in the lung. Because the change

  10. Lung Cancer (2004) 46, 333--340 High serum YKL-40 level in patients with small

    E-Print Network [OSTI]

    Price, Paul A.

    2004-01-01T23:59:59.000Z

    Lung Cancer (2004) 46, 333--340 High serum YKL-40 level in patients with small cell lung cancer May 2004; accepted 6 May 2004 KEYWORDS Small cell lung carcinoma; Tumor invasiveness; YKL-40; HC gp-39 evaluated serum YKL-40 in 131 patients with small cell lung cancer (SCLC). Twenty-two percent

  11. Automated Lung Nodule Segmentation Using Dynamic Programming and EM Based Classification

    E-Print Network [OSTI]

    Ahuja, Narendra

    Automated Lung Nodule Segmentation Using Dynamic Programming and EM Based Classification Ning Xua a robust and automated algorithm to segment lung nodules in three dimensional (3D) Computed Tomography (CT nodules but also the nodules attached to lung walls and vessels. Keywords: Lung nodule, Segmentation

  12. Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer

    E-Print Network [OSTI]

    Cai, Long

    Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer, Timothy Anderson6, Norman Gerry7, Joseph Keane4, Marc E Lenburg7 & Jerome S Brody1 Lung cancer smokers with suspicion of lung cancer could be used as a lung cancer biomarker. Using a training set (n

  13. Single-Session Radiofrequency Ablation of Bilateral Lung Metastases

    SciTech Connect (OSTI)

    Palussiere, Jean, E-mail: palussiere@bergonie.org; Gomez, Fernando; Cannella, Matthieu; Ferron, Stephane; Descat, Edouard [Institut Bergonie, Department of Radiology, Regional Cancer Centre (France); Fonck, Marianne [Institut Bergonie, Department of Digestive Oncology (France); Brouste, Veronique [Institut Bergonie, Clinical and Epidemiological Research Unit (France); Avril, Antoine [Institut Bergonie, Department of Surgery (France)

    2012-08-15T23:59:59.000Z

    Purpose: This retrospective study examined the feasibility and efficacy of bilateral lung radiofrequency ablation (RFA) performed in a single session. Methods: From 2002-2009, patients with bilateral lung metastases were treated by RFA, where possible in a single session under general anesthesia with CT guidance. The second lung was punctured only if no complications occurred after treatment of the first lung. Five lung metastases maximum per patient were treated by RFA and prospectively followed. The primary endpoint was the evaluation of acute and delayed complications. Secondary endpoints were calculation of hospitalization duration, local efficacy, median survival, and median time to tumor progression. Local efficacy was evaluated on CT or positron emission tomography (PET) CT. Results: Sixty-seven patients were treated for bilateral lung metastases with RFA (mean age, 62 years). Single-session treatment was not possible in 40 due to severe pneumothoraces (n = 24), bilateral pleural contact (n = 14), and operational exclusions (n = 2). Twenty-seven (41%) received single-session RFA of lesions in both lungs for 66 metastases overall. Fourteen unilateral and four bilateral pneumothoraces occurred (18 overall, 66.7%). Unilateral (n = 13) and bilateral (n = 2) chest tube drainage was required. Median hospitalization was 3 (range, 2-8) days. Median survival was 26 months (95% confidence interval (CI), 19-33). Four recurrences on RFA sites were observed (4 patients). Median time to tumor progression was 9.5 months (95% CI, 4.2-23.5). Conclusions: Although performing single-session bilateral lung RFA is not always possible due to pneumothoraces after RFA of first lung, when it is performed, this technique is safe and effective.

  14. AmericanGeneticAssociation ISSN 0022-1503 (Print)

    E-Print Network [OSTI]

    Browne, William E.

    Resources to Study Diverse Invertebrate Genomes GIGA CommunIty of SCIentIStS* Address correspondence to Dr a blastula stage, which is followed by cell differentiation and morphogenesis (Slack et al. 1993; Valentine

  15. source: American Forest & Paper Association Test Your Knowledge of Forest

    E-Print Network [OSTI]

    Beex, A. A. "Louis"

    years ago Question 4: Timber growth in the United States exceeds harvest and losses due to insects the SFI program, member companies reforested 1.3 million acres by planting, seeding, & natural regeneration bringing the three year total for reforested company lands to: a) 3.3 million b) 2.7 million c) 3

  16. American Gas Association Memorandum Summarizing Ex Parte Communication...

    Broader source: Energy.gov (indexed) [DOE]

    at WGLs Training Facility in Springfield, VA. AGA Memorandum Summarizing Ex Parte Communication Condensing Heating and Water Heating Equipment Workshop Agenda October 9th...

  17. american diabetes association: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and without diabetes in 2002 by sex, age, raceethnicity, type of medical condition, and health care setting. Health care use and total health care expenditures attributable to...

  18. LOS ALAMOS, New Mexico, December 15, 2011-The American Association...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    such projects as the improved efficiency of plant photosynthesis, advances in - 2 - algae production and harvesting, and understanding the biochemical and biophysical processes...

  19. QER- Comment of American Wind Energy Association 2

    Broader source: Energy.gov [DOE]

    QER Task Force – Attached please find brief supplemental comments that AWEA would like to submit for your consideration as you continuing drafting the QER.

  20. QER- Comment of American Public Power Association 3

    Broader source: Energy.gov [DOE]

    Attached are APPA’s comments for the Second public QER meeting. I have tried to submit these before too, so please send me a confirmation e-mail. Thanks in advance for your consideration of my request.

  1. QER- Comment of American Public Power Association 4

    Broader source: Energy.gov [DOE]

    I am not sure these made the record for the QER either, so I am sending them again. Sorry for all the e-mail, but I want to make sure these documents make the record. Thanks, and please enjoy the rest of your Sunday.

  2. Comments of the American Public Power Association | Department of Energy

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011AT&T, Inc.'sEnergyTexas1.Space Data Corporation Comments of

  3. American Wind Energy Association Offshore WINDPOWER Conference & Exhibition

    Broader source: Energy.gov [DOE]

    AWEA Offshore WINDPOWER 2014 Conference & Exhibition is the largest offshore wind energy event in North America. The conference and exhibition will be held at the Atlantic City Convention...

  4. Home Energy Score Program Overview for the American Gas Association...

    Energy Savers [EERE]

    Here we can enter either the efficiency value -- the AFUE in the case of gas or propane or oil. If you don't know that, you can use an installed year. This gives a...

  5. Comments of The American Public Power Association | Department of Energy

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 111 1,613PortsmouthBartlesville EnergyDepartment. CashDay-June 22, 2015Policy |

  6. SRS employees raise funds for American Heart Association | National Nuclear

    National Nuclear Security Administration (NNSA)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilA groupTuba City,Enriched UraniumPhysical SecurityRespondingSecurity

  7. Fall 2006 Meeting of theAmerican Statistical Association

    Annual Energy Outlook 2013 [U.S. Energy Information Administration (EIA)]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 111 1,613 122 40 Buildingto17 3400, U.S.MajorMarkets EnergyConsumption5Values shown FOR565

  8. American Gas Association Memorandum Summarizing Ex Parte Communication |

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed off Energy.gov. Are you0 ARRA Newsletters 20103-03EnergyAlternativeAmerica's Next

  9. American Gas Association Ex Parte Communication | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you're a16-17,2-13) All Other

  10. Comments of The American Public Power Association | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: Theof"Wave the WhiteNational Broadband PlanSpace Data Corporationfrom

  11. American Wind Energy Association AWEA | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual Siteof Energy 2,AUDIT REPORT Americium/CuriumAgua Caliente SolarAltenoASES JumpAWEA Jump

  12. American Bar Association Section on Environment | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to:Ezfeedflag JumpID-fTriWildcat Place:Alvan Blanch GreenAmeren Illinois Company

  13. American Gas Association (AGA) for DOE Furnace Product Class | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The Future of1Albuquerque, NM -Alicia MoultonPassEnergy InnovatorTurning Energyof

  14. American Gas Association Ex Parte Communication | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The Future of1Albuquerque, NM -Alicia MoultonPassEnergy InnovatorTurning

  15. Sandia Energy - Two Sandia Leaders Elected American Association for the

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiationImplementing Nonlinear757KelleyEffectsonSandia's StanBurner

  16. American Wind Energy Association (AWEA) | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual Siteof Energy 2,AUDITCaliforniaWeifangwikiAgouraAlbatechFuelsdieselEnergy Society

  17. Competition and Reliability in North American Electricity Markets...

    Energy Savers [EERE]

    Electricity Markets Technical Workshop Competition and Reliability in North American Electricity Markets Technical Workshop Competition and Reliability in North American...

  18. american students utilizing: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    PARTNERS American Institute of Chemical Engineers Alpha Omega Epsilon International Engineering & Technical Science Sorority American Society of Heating, Refrigerating and...

  19. Moral pressure : American democracy and Chinese human rights

    E-Print Network [OSTI]

    Chan, Stephanie Tze-Hua

    2011-01-01T23:59:59.000Z

    of the Sino-American agreement on nuclear cooperation, andof the Sino-American agreement on nuclear cooperation, and

  20. Fuel Cell Manufacturing: American Energy and Manufacturing Competitive...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Fuel Cell Manufacturing: American Energy and Manufacturing Competitiveness Summit Fuel Cell Manufacturing: American Energy and Manufacturing Competitiveness Summit Presentation on...

  1. IEEE TRANSACTIONS ON ROBOTICS AND AUTOMATION, VOL. 19, NO. 5, OCTOBER 2003 917 lung collapse and gas insufflation). To determine the effects of lung

    E-Print Network [OSTI]

    Whitcomb, Louis L.

    IEEE TRANSACTIONS ON ROBOTICS AND AUTOMATION, VOL. 19, NO. 5, OCTOBER 2003 917 lung collapse and gas insufflation). To determine the effects of lung collapse and insufflation, this port site

  2. Functional lung imaging in humans using Positron Emission Tomography

    E-Print Network [OSTI]

    Layfield, Dominick, 1971-

    2003-01-01T23:59:59.000Z

    This thesis deals with a method of functional lung imaging using Positron Emission Tomography (PET). In this technique, a radioactive tracer, nitrogen-13, is dissolved in saline solution, and injected into a peripheral ...

  3. Tumour microenvironment interactions of small cell lung cancer. 

    E-Print Network [OSTI]

    Hodkinson, Philip Simon

    2009-01-01T23:59:59.000Z

    Small cell lung cancer (SCLC) is characterised by rapid growth, early metastatic spread and poor long-term survival. The tumour is initially sensitive to chemotherapy and thus objective response rates are high. Unfortunately, ...

  4. Role of myeloid Hif-1? in acute lung injury 

    E-Print Network [OSTI]

    MacDuff, Andrew

    2011-07-05T23:59:59.000Z

    Acute Lung Injury, characterised clinically as the Acute Respiratory Distress Syndrome is a catastrophic response to a range of pulmonary and non-pulmonary insults. Despite much work the key mechanisms involved in generating the exaggerated immune...

  5. HIF-2? deletion promotes Kras-driven lung tumor development

    E-Print Network [OSTI]

    Jacks, Tyler E.

    Non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths worldwide. The oxygen-sensitive hypoxia inducible factor (HIF) transcriptional regulators HIF-1? and HIF-2? are overexpressed in many human NSCLCs, ...

  6. Selectins Mediate Small Cell Lung Cancer Systemic Metastasis

    E-Print Network [OSTI]

    Heidemann, Franziska

    Metastasis formation is the major reason for the extremely poor prognosis in small cell lung cancer (SCLC) patients. The molecular interaction partners regulating metastasis formation in SCLC are largely unidentified, ...

  7. a549 human lung: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human (more) Weems, Jessica Marie 2010-01-01 26 KILLING OF TARGET CELLS DUE TO RADON PROGENY IN THE HUMAN LUNG Physics Websites Summary: to the epidemiologically derived value...

  8. aerosol lung inhalation: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    This work describes a pilot study to calculate lung dose from the deposition of radon progeny, via estimates of cumulative exposure derived from in vivo measurements of sup 2...

  9. A statistical analysis of lead concentrations in human lung samples

    E-Print Network [OSTI]

    Stringer, Claude Allen

    1973-01-01T23:59:59.000Z

    A STATISTICAL ANALYSIS OF LEAD CONCENTRATIONS IN HUMAN LUNG SAMPLES A Thesis by CLAUDE ALLEN STRINGER, JR. Submitted to the Graduate College of Texas ASM University in partial fulfillment of the requirement for the degree of MASTER... OF SCIENCE May 1973 Major Subject: Chemistry A STATISTICAL ANALYSIS OF LEAD CONCENTRATIONS IN HUMAN LUNG SAMPLES A Thesis CLAUDE ALLEN STRINGER, JR. Approved as to style and content by: (Chairman of Commi e) (Head of Department) C Member (Memb...

  10. Combustion-derived flame generated ultrafine soot generates reactive oxygen species and activates Nrf2 antioxidants differently in neonatal and adult rat lungs

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    neonatal and adult rat lungs. Particle and Fibre Toxicologysensitivity of the postnatal lung to environmental insultsdevelopment of the human lung. Prog Clin Biol Res 1983, 140:

  11. A report by Civic Enterprises and the National Peace Corps Association in partnership with Peter D. Hart Research Associates

    E-Print Network [OSTI]

    Fraden, Seth

    . Hart Research Associates By: John M. Bridgeland, Harris Wofford, Kevin F.F. Quigley, Jessica A. Milano PASSPORTS--ONE STAMPED AMERICAN,PASSPORTS--ONE STAMPED AMERICAN, T H E O T H E R H U M A N B E I N G . W E A R ET H E O T H E R H U M A N B E I N G . W E A R E MEMBERS OF THE SAME GREAT RACE, BUTMEMBERS

  12. The Puzzle of Hypertension in African-Americans56 Scientific American February 1999 The Puzzle of

    E-Print Network [OSTI]

    Fraden, Seth

    The Puzzle of Hypertension in African-Americans56 Scientific American February 1999 The Puzzle of Hypertension in African-Americans by Richard S. Cooper, Charles N. Rotimi and Ryk Ward N early all Americans undergo a steady rise in blood pressure with age. Almost 25 percent cross the line into hypertension

  13. Information Technology: American National Standard for

    E-Print Network [OSTI]

    Information Technology: American National Standard for Information Systems-- Data Format Publication 500-245 Information Technology: American National Standard for Information Systems-- Data Format for the Interchange of Fingerprint, Facial, & Scar Mark & Tattoo (SMT) Information Sponsored by Information Technology

  14. American Range: Order (2014-CE-23006)

    Broader source: Energy.gov [DOE]

    DOE ordered American Range Corporation to pay a $8,000 civil penalty after finding American Range had failed to certify that certain models of cooking products comply with the applicable energy conservation standards.

  15. Heart Healthy Home Cooking African American Style

    E-Print Network [OSTI]

    Bandettini, Peter A.

    Heart Healthy Home Cooking African American Style With Every Heartbeat Is Life #12;#12;Heart Recipe Substitutions for Heart Healthy Cooking at the heart of African American family life and special celebrations. This recipe book brings together many

  16. American Valve: Order (2010-CW-1411)

    Broader source: Energy.gov [DOE]

    DOE ordered American Valve, Inc. to pay a $5,000 civil penalty after finding American Valve had failed to certify that certain showerhead models comply with the applicable water conservation standards.

  17. Information Technology: American National Standard for Information

    E-Print Network [OSTI]

    Information Technology: American National Standard for Information Systems-- Data Format-271 Information Technology: American National Standard for Information Systems-- Data Format for the Interchange Sponsored by Information Access Division Information Technology Laboratory National Institute of Standards

  18. Information Technology: American National Standard for Information

    E-Print Network [OSTI]

    Information Technology: American National Standard for Information Systems-- Data Format 500-275 Information Technology: American National Standard for Information Systems-- Data Format Coleman, and Patrice Yuh, Editors Sponsored by Information Access Division Information Technology

  19. Dissertations Recently Completed on Latin American Theatre

    E-Print Network [OSTI]

    1980-04-01T23:59:59.000Z

    4 LATIN AMERICAN THEATRE REVIEW Dissertations Recently Completed on Latin American Theatre Ascarrunz-Gilman, Graciela. "El sentido religioso del teatro de Carlos Solór- zano." (California, Davis) Bixler, Jacqueline Eyring. "Theory and Technique...

  20. Stat 301 Lab 7: Due October 27 Fall 2014 1. For many children with asthma, or other lung problems, measurement of lung function is an

    E-Print Network [OSTI]

    Carriquiry, Alicia

    1 Stat 301 Lab 7: Due October 27 Fall 2014 1. For many children with asthma, or other lung problems, measurement of lung function is an important part of staying healthy. Forced Expiratory Volume (FEV) is the volume of air that can be forcibly expelled from the lungs after full inspiration. A random sample of 100

  1. 60. LUNG .13 NORMAL VARIANT .31 BENIGN NEOPI,J.SM, CYST, 6l. RIGHT .131 NORMAL VARIANT, OTHER NEOPLS

    E-Print Network [OSTI]

    [ ~;{(, (1) Lungs 60. LUNG .13 NORMAL VARIANT .31 BENIGN NEOPI,J.SM, CYST, 6l. RIGHT .131 IN LUNG BRONCHI .221 SARCOIDOSIS, 672. SUPERIOR ADENOPATHY MEDIASTINUN .222 SARCOIDOSIS, 673 68. MORE THAN 1 LUNG PLRA, MEDIAST. , LOCATION (GNRLIZED) 69. OTHER-(LUNG, PLRA, MEDIAST

  2. TRANSACTIONS OF THE AMERICAN MATHEMATICAL SOCIETY

    E-Print Network [OSTI]

    Willenbring, Jeb F.

    fellowship. c 2002 American Mathematical Society 4393 #12;4394 JEB F. WILLENBRING on V , under the usual

  3. NATIVE AMERICAN HISTORY Libby R. Tronnes

    E-Print Network [OSTI]

    Wisconsin at Madison, University of

    , and Demography" CAIH (2002) Indians in the American South Post-Contact Gallay, Alan. The Indian Slave Trade

  4. SU-E-J-86: Lobar Lung Function Quantification by PET Galligas and CT Ventilation Imaging in Lung Cancer Patients

    SciTech Connect (OSTI)

    Eslick, E; Kipritidis, J; Keall, P [University of Sydney, Camperdown, NSW (Australia); Bailey, D; Bailey, E [Royal North Shore Hospital, St. Leonards, NSW (Australia)

    2014-06-01T23:59:59.000Z

    Purpose: The purpose of this study was to quantify the lobar lung function using the novel PET Galligas ([68Ga]-carbon nanoparticle) ventilation imaging and the investigational CT ventilation imaging in lung cancer patients pre-treatment. Methods: We present results on our first three lung cancer patients (2 male, mean age 78 years) as part of an ongoing ethics approved study. For each patient a PET Galligas ventilation (PET-V) image and a pair of breath hold CT images (end-exhale and end-inhale tidal volumes) were acquired using a Siemens Biograph PET CT. CT-ventilation (CT-V) images were created from the pair of CT images using deformable image registration (DIR) algorithms and the Hounsfield Unit (HU) ventilation metric. A comparison of ventilation quantification from each modality was done on the lobar level and the voxel level. A Bland-Altman plot was used to assess the difference in mean percentage contribution of each lobe to the total lung function between the two modalities. For each patient, a voxel-wise Spearmans correlation was calculated for the whole lungs between the two modalities. Results: The Bland-Altman plot demonstrated strong agreement between PET-V and CT-V for assessment of lobar function (r=0.99, p<0.001; range mean difference: ?5.5 to 3.0). The correlation between PET-V and CT-V at the voxel level was moderate(r=0.60, p<0.001). Conclusion: This preliminary study on the three patients data sets demonstrated strong agreement between PET and CT ventilation imaging for the assessment of pre-treatment lung function at the lobar level. Agreement was only moderate at the level of voxel correlations. These results indicate that CT ventilation imaging has potential for assessing pre-treatment lobar lung function in lung cancer patients.

  5. Economic Impact of the American Clean Energy

    E-Print Network [OSTI]

    Mohaghegh, Shahab

    Economic Impact of the American Clean Energy and Security Act of 2009 on the West Virginia Economy ........................................................................................................................ 1 American Clean Energy and Security Act of 2009 at reducing greenhouse gas emissions. This report examines the impact of the American Clean Energy

  6. Leonard Wood and the American Empire

    E-Print Network [OSTI]

    Pruitt, James Herman

    2012-07-16T23:59:59.000Z

    During the ten years following the Spanish American War (1898 to 1908), Major General Leonard Wood served as the primary agent of American imperialism. Wood was not only a proconsul of the new American Empire; he was a symbol of the empire...

  7. Local Failure in Resected N1 Lung Cancer: Implications for Adjuvant Therapy

    SciTech Connect (OSTI)

    Higgins, Kristin A., E-mail: kristin.higgins@duke.edu [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States); Chino, Junzo P. [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States); Berry, Mark [Department of Surgery, Division of Cardiovascular and Thoracic Surgery, Duke University Medical Center, Durham, NC (United States); Ready, Neal [Department of Medicine, Division of Medical Oncology, Duke University Medical Center, Durham, NC (United States); Boyd, Jessamy [US Oncology, Dallas, TX (United States); Yoo, David S.; Kelsey, Chris R. [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States)

    2012-06-01T23:59:59.000Z

    Purpose: To evaluate actuarial rates of local failure in patients with pathologic N1 non-small-cell lung cancer and to identify clinical and pathologic factors associated with an increased risk of local failure after resection. Methods and Materials: All patients who underwent surgery for non-small-cell lung cancer with pathologically confirmed N1 disease at Duke University Medical Center from 1995-2008 were identified. Patients receiving any preoperative therapy or postoperative radiotherapy or with positive surgical margins were excluded. Local failure was defined as disease recurrence within the ipsilateral hilum, mediastinum, or bronchial stump/staple line. Actuarial rates of local failure were calculated with the Kaplan-Meier method. A Cox multivariate analysis was used to identify factors independently associated with a higher risk of local recurrence. Results: Among 1,559 patients who underwent surgery during the time interval, 198 met the inclusion criteria. Of these patients, 50 (25%) received adjuvant chemotherapy. Actuarial (5-year) rates of local failure, distant failure, and overall survival were 40%, 55%, and 33%, respectively. On multivariate analysis, factors associated with an increased risk of local failure included a video-assisted thoracoscopic surgery approach (hazard ratio [HR], 2.5; p = 0.01), visceral pleural invasion (HR, 2.1; p = 0.04), and increasing number of positive N1 lymph nodes (HR, 1.3 per involved lymph node; p = 0.02). Chemotherapy was associated with a trend toward decreased risk of local failure that was not statistically significant (HR, 0.61; p = 0.2). Conclusions: Actuarial rates of local failure in pN1 disease are high. Further investigation of conformal postoperative radiotherapy may be warranted.

  8. Predictive Factors of Late Radiation Fibrosis: A Prospective Study in Non-Small Cell Lung Cancer

    SciTech Connect (OSTI)

    Mazeron, Renaud [University of Lyon, Centre Leon Berard, Department of Radiation Oncology, Lyon (France); Etienne-Mastroianni, Benedicte [Hopital Louis Pradel, Department of Pneumology, Lyon (France); Perol, David [University of Lyon, Centre Leon Berard, Departement of Public Health, Lyon (France); Arpin, Dominique [Hopital de la Croix-Rousse, Department of Pneumology, Lyon (France); Vincent, Michel [Hopital Saint Luc-Saint Joseph, Department of Pneumology, Lyon (France); Falchero, Lionel [Centre Hospitalier General, Department of Pneumology, Villefranche sur Saone (France); Martel-Lafay, Isabelle; Carrie, Christian [University of Lyon, Centre Leon Berard, Department of Radiation Oncology, Lyon (France); Claude, Line, E-mail: claude@lyon.fnclcc.f [University of Lyon, Centre Leon Berard, Department of Radiation Oncology, Lyon (France)

    2010-05-01T23:59:59.000Z

    Purpose: To determine predictive factors of late radiation fibrosis (RF) after conformal radiotherapy (3D-RT) in non-small cell lung cancer (NSCLC). Methods and Materials: Ninety-six patients with Stage IA-IIIB NSCLC were included in a prospective trial. Clinical evaluation, chest X-ray, and pulmonary functional tests including diffusion parameters were performed before and 6 months after radiotherapy. An independent panel of experts prospectively analyzed RF, using Late Effects in Normal Tissues-Subjective, Objective, Management and Analytic scales classification. Logistic regression analysis was performed to identify relationships between clinical, functional, or treatment parameters and incidence of RF. Variations of circulating serum levels of pro-inflammatory (interleukin-6, tumor necrosis factor alpha, tumor growth factor beta1) and anti-inflammatory (interleukin-10) cytokines during 3D-RT were examined to identify correlations with RF. Results: Of the 96 patients included, 72 were evaluable for RF at 6 months. Thirty-seven (51.4%) developed RF (Grade >=1), including six severe RF (Grades 2-3; 8.3%). In univariate analysis, only poor Karnofsky Performance Status and previous acute radiation pneumonitis were associated with RF (p < 0.05). Dosimetric factors (mean lung dose, percentage of lung volume receiving more than 10, 20, 30, 40, and 50 Gy) were highly correlated with RF (p < 0.001). In multivariate analysis, previous acute radiation pneumonitis and dosimetric parameters were significantly correlated with RF occurrence. It was not significantly correlated either with cytokines at baseline or with their variation during 3D-RT. Conclusions: This study confirms the importance of dosimetric parameters to limit the risk of RF. Contrary to acute radiation pneumonitis, RF was not correlated to cytokine variations during 3D-RT.

  9. Effects of dietary carotenoids on mouse lung genomic profiles and their modulatory effects on short-term cigarette smoke exposures

    E-Print Network [OSTI]

    2009-01-01T23:59:59.000Z

    effects on the activity of the lung transcriptome (*8,500of the two CARs on the lung transcriptome were further50 genes detected in the lungs of CS-exposed mice. These

  10. Phenotypic Plasticity in the Lungs of Deer Mice (Peromyscus maniculatus) at High Altitude and the Relationship With Aerobic Performance

    E-Print Network [OSTI]

    Shirkey, Nicholas Joseph

    2013-01-01T23:59:59.000Z

    altitude exposure on the lungs of young rats. RespirationDiffusing capacity of the lung in Caucasians native to 3,100of the ultrastructure of the lungs of wild mice living at

  11. Integrated analysis of microRNA expression and mRNA transcriptome in lungs of avian influenza virus infected broilers

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    expressed miRNAs in chicken lung and trachea with avianagainst Ventilator-induced Lung Injury. Am J Resp Crit Careand mRNA transcriptome in lungs of avian influenza virus

  12. Expression of Phosphorylated Raf Kinase Inhibitor Protein (pRKIP) is a Predictor of Lung Cancer Survival

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    pRKIP) is a predictor of lung cancer survival Sara Huerta-RKIP and phospho-RKIP in human lung cancer tissue microarrayand in those with early stage lung cancer. Conclusions: This

  13. Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction ¿ a randomised placebo-controlled trial (KARE): study protocol

    E-Print Network [OSTI]

    Cross, Laurence JM; O’Kane, Cecilia M; McDowell, Cliona; Elborn, Jospeh J; Matthay, Michael A; McAuley, Daniel F

    2013-01-01T23:59:59.000Z

    growth factor in acute lung injury to reduce pulmonaryV, Matthay MA: Acid-induced lung injury. Protective effectof patients with acute lung injury and the acute respiratory

  14. Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    disease in non-small cell lung cancer. Semin ThoracW, Khuri FR: The care of the lung cancer patient in the 21stJablons DM: Wnt signaling in lung cancer. Cancer Lett 2005,

  15. The Role of PKR/eIF2 alpha Signaling Pathway in Prognosis of Non-Small Cell Lung Cancer

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    Bronchioloalveolar carcinoma and lung adenocarcinoma: thePrognosis of Non-Small Cell Lung Cancer Yong He 1,2 , Arlenevariable for non-small cell lung cancer patients. Clin

  16. Evaluation of Irinotecan as a Third- or Fourth-line Treatment for Advanced Non-small Cell Lung Cancer

    E-Print Network [OSTI]

    Keener, James

    2013-01-01T23:59:59.000Z

    Advanced Non–Small-Cell Lung Cancer: An Individual PatientChemotherapy of Non-Small Cell Lung Cancer in the Elderly."Lung Cancer 38, Supplement 3.0 (2002): 67-70. Print. "

  17. Figure 6: An MTAH for 11 lung tumor contours generated by MDISC based on area, circularity, and extrusiveness.

    E-Print Network [OSTI]

    California at Los Angeles, University of

    Figure 6: An MTAH for 11 lung tumor contours generated by M­DISC based on area, circularity, and extrusiveness. Figure 7: The CT scanned lung image for image 6 (in Figure 3) with the lung tumor contour

  18. September 2010 American Recovery and

    E-Print Network [OSTI]

    Oak Ridge National Laboratory

    September 2010 i American Recovery and Reinvestment Act (ARRA) FEMP Technical Assistance U.S. Naval by applying GSHP systems. The current HVAC system for the building is a conventional Air Handling Unit (AHU) system with chiller. The heating and the DHW are provided by district steam. The building is close

  19. North American Cross-Border

    E-Print Network [OSTI]

    sourced steam coal burnt in power plants in the northeastern portion of the United States. As coal mining of electrical power from Canada appears to have little impact on the production of steam coal in VirginiaNorth American Cross-Border Electricity Trade Ian M. Loomis Virginia Center for Coal and Energy

  20. Accelerated hypofractionated radiation therapy compared to conventionally fractionated radiation therapy for the treatment of inoperable non-small cell lung cancer

    E-Print Network [OSTI]

    Amini, Arya; Lin, Steven H; Wei, Caimiao; Allen, Pamela; Cox, James D; Komaki, Ritsuko

    2012-01-01T23:59:59.000Z

    of inoperable non-small cell lung cancer. Radiation Oncologystage iii non-small cell lung cancer: randomized phase IIIfactors for non-small cell lung cancer. Lung Cancer 1997,

  1. Primary cystic lung light chain deposition disease: a clinicopathologic entity derived from unmutated B cells with a stereotyped IGHV4-34/IGKV1 receptor

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Primary cystic lung light chain deposition disease: a clinicopathologic entity derived from deposition disease (LCDD) presenting as a severe cystic lung disorder requiring lung transplantation lung transplantation and of serum free light chain ratio normalization after the procedure, we

  2. QER- Comment of American Water

    Broader source: Energy.gov [DOE]

    Dear QER Team; Thank you for the opportunity to provide comments to the Quadrennial Energy Review Task Force to discuss the water and energy nexus, advances in water innovative technologies, and the impact of climate change on water issues. On behalf of American Water, I wish to submit the following White Papers which we have prepared on these critical issues: Innovations in Energy Use Sustainability and Resiliency Planning for Water Utilities One Water Water/Energy Correlation The Value of Water Challenges in the Water Industry: Climate Change Challenges in the Water Industry: Meeting Demand in the West Innovation Solutions Within the Water Industry: Desalination Innovation Solutions Within the Water Industry: Going Green Innovation Solutions Within the Water Industry: Water Reuse Bridging the Water Innovation Gap. Founded in 1886, American Water is the largest publicly traded U.S. water and wastewater utility company. With headquarters in Voorhees, NJ, the company employs approximately 6,600 dedicated professionals who provide drinking water, wastewater and other related services to an estimated 14 million people in more than 40 states. Please feel free to contact me if you have any questions or if there is any way American Water can be helpful to your mission. Respectfully Yours, Martin (See attached file: White Papers.pdf) Martin D. Kerckhoff Vice President and Divisional General Counsel Central Division American Water CONFIDENTIAL & PRIVILEGED COMMUNICATION This email and any attachments hereto constitute a legally confidential communication from the Legal Department of American Water. The information contained herein is subject to attorney-client privilege and is for the sole use of the intended original addressee. If you are not the intended original addressee, you are hereby notified that any reading, disclosure, copying, distribution, use, or taking of any action in reliance on the contents contained herein is strictly prohibited. If you have received this message in error, please immediately notify us at 314.966.2241 and delete this message from your system. WARNING: Although American Water has taken reasonable precautions to ensure that no viruses are present in this email, it is the responsibility of the recipient to ensure that it is virus free. No responsibility is accepted by American Water for any loss or damage arising in any way from the receipt and/or use of this email.

  3. Renewable energy for federal facilities serving native Americans: preprint

    SciTech Connect (OSTI)

    Eiffert, P.; Sprunt Crawley, A.; Bartow, K.

    2000-05-15T23:59:59.000Z

    The Federal Energy Management Program (FEMP) in the U.S. Department of Energy (DOE) is targeting Federal facilities serving Native American populations for cost-effective renewable energy projects. These projects not only save energy and money, they also provide economic opportunities for the Native Americans who assist in producing, installing, operating, or maintaining the renewable energy systems obtained for the facilities. The systems include solar heating, solar electric (photovoltaic or PV), wind, biomass, and geothermal energy systems. In fiscal years 1998 and 1999, FEMP co-funded seven such projects, working with the Indian Health Service in the U.S. Department of Health and Human Services, the Bureau of Indian Affairs in the U.S. Department of the Interior, and their project partners. The new renewable energy systems are helping to save money that would otherwise be spent on conventional energy and reduce the greenhouse gases associated with burning fossil fuels.

  4. SU-E-J-185: Gated CBCT Imaging for Positioning Moving Lung Tumor in Lung SBRT Treatment

    SciTech Connect (OSTI)

    Li, X; Li, T; Zhang, Y; Burton, S; Karlovits, B; Clump, D; Heron, D; Huq, M [University of Pittsburgh Medical Center, Pittsburgh, PA (United States)

    2014-06-01T23:59:59.000Z

    Purpose: Lung stereo-tactic body radiotherapy(SBRT) treatment requires high accuracy of lung tumor positioning during treatment, which is usually accomplished by free breathing Cone-Beam computerized tomography (CBCT) scan. However, respiratory motion induced image artifacts in free breathing CBCT may degrade such positioning accuracy. The purpose of this study is to investigate the feasibility of gated CBCT imaging for lung SBRT treatment. Methods: Six Lung SBRT patients were selected for this study. The respiratory motion of the tumors ranged from 1.2cm to 3.5cm, and the gating windows for all patients were set between 35% and 65% of the respiratory phases. Each Lung SBRT patient underwent free-breathing CBCT scan using half-fan scan technique. The acquired projection images were transferred out for off-line analyses. An In-house semi-automatic algorithm was developed to trace the diaphragm movement from those projection images to acquire a patient's specific respiratory motion curve, which was used to correlate respiratory phases with each projection image. Afterwards, a filtered back-projection algorithm was utilized to reconstruct the gated CBCT images based on the projection images only within the gating window. Results: Target volumes determined by free breathing CBCT images were 71.9%±72% bigger than the volume shown in gated CBCT image. On the contrary, the target volume differences between gated CBCT and planning CT images at exhale stage were 5.8%±2.4%. The center to center distance of the targets shown in free breathing CBCT and gated CBCT images were 9.2±8.1mm. For one particular case, the superior boundary of the target was shifted 15mm between free breathing CBCT and gated CBCT. Conclusion: Gated CBCT imaging provides better representation of the moving lung tumor with less motion artifacts, and has the potential to improve the positioning accuracy in lung SBRT treatment.

  5. Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells

    SciTech Connect (OSTI)

    Stueckle, Todd A., E-mail: tstueckle@hsc.wvu.edu [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States); Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Lu, Yongju, E-mail: yongju6@hotmail.com [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States)] [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States); Davis, Mary E., E-mail: mdavis@wvu.edu [Department of Physiology, West Virginia University, Morgantown, WV 26506 (United States); Wang, Liying, E-mail: lmw6@cdc.gov [Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States)] [Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Jiang, Bing-Hua, E-mail: bhjiang@jefferson.edu [Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107 (United States)] [Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107 (United States); Holaskova, Ida, E-mail: iholaskova@hsc.wvu.edu [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States)] [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States); Schafer, Rosana, E-mail: rschafer@hsc.wvu.edu [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States)] [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States); Barnett, John B., E-mail: jbarnett@hsc.wvu.edu [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States); Rojanasakul, Yon, E-mail: yrojan@hsc.wvu.edu [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States)] [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States)

    2012-06-01T23:59:59.000Z

    Chronic arsenic exposure remains a human health risk; however a clear mode of action to understand gene signaling-driven arsenic carcinogenesis is currently lacking. This study chronically exposed human lung epithelial BEAS-2B cells to low-dose arsenic trioxide to elucidate cancer promoting gene signaling networks associated with arsenic-transformed (B-As) cells. Following a 6 month exposure, exposed cells were assessed for enhanced cell proliferation, colony formation, invasion ability and in vivo tumor formation compared to control cell lines. Collected mRNA was subjected to whole genome expression microarray profiling followed by in silico Ingenuity Pathway Analysis (IPA) to identify lung carcinogenesis modes of action. B-As cells displayed significant increases in proliferation, colony formation and invasion ability compared to BEAS-2B cells. B-As injections into nude mice resulted in development of primary and secondary metastatic tumors. Arsenic exposure resulted in widespread up-regulation of genes associated with mitochondrial metabolism and increased reactive oxygen species protection suggesting mitochondrial dysfunction. Carcinogenic initiation via reactive oxygen species and epigenetic mechanisms was further supported by altered DNA repair, histone, and ROS-sensitive signaling. NF-?B, MAPK and NCOR1 signaling disrupted PPAR?/?-mediated lipid homeostasis. A ‘pro-cancer’ gene signaling network identified increased survival, proliferation, inflammation, metabolism, anti-apoptosis and mobility signaling. IPA-ranked signaling networks identified altered p21, EF1?, Akt, MAPK, and NF-?B signaling networks promoting genetic disorder, altered cell cycle, cancer and changes in nucleic acid and energy metabolism. In conclusion, transformed B-As cells with their whole genome expression profile provide an in vitro arsenic model for future lung cancer signaling research and data for chronic arsenic exposure risk assessment. Highlights: ? Chronic As{sub 2}O{sub 3} exposure to lung epithelial cells resulted in a cancer-like phenotype. ? Mice injected with arsenic transformed (B-As) cells displayed metastatic tumors. ? Microarray profiling revealed changes in mitochondrial metabolism and ROS response. ? p21, EF1?, Akt, MAPK, PPAR? and NF-?B networks promoted pro-cancer signaling. ? B-As cells represent a lung cancer model to explore As-associated carcinogenesis.

  6. Is lung sequestration of indium-111-labeled granulocytes organ specific

    SciTech Connect (OSTI)

    Williams, J.H. Jr.; Wilson, A.F.; Moser, K.M. (Univ. of California, Irvine (USA))

    1989-09-01T23:59:59.000Z

    Transient sequestration of polymorphonuclear leukocytes (PMN) in the normal lungs of animals occurred immediately following intravenous injection of 111In-labeled PMN. We investigated the organ specificity of this process. Equal amounts of homologous PMN, derived from the intravascular space and labeled with (111In)oxine, were infused either intravenously (i.v.) or intraarterially (i.a.) into pairs of rats. Changes in radioactivity emitted from three regions--representing lung, liver and spleen, and lower body--were determined from images during the following hour. A nonspecific character was demonstrated by the transient sequestration of activity in the lower body following i.a. infusions. However, the rate of initial clearance of activity (first 30 min) from the lungs of i.v.-infused rats was relatively slower than from the lower body of i.a.-infused rats. This suggests the presence of a lung-specific as well, which may be important for localization of PMN-related events to the lung.

  7. Modifiers of Exposure-Response Estimates for Lung Cancer among Miners Exposed to Radon Progeny

    E-Print Network [OSTI]

    Richard W. Hornung; James Deddens; Robert Roscoe

    The association between lung cancer and exposure to radon decay products has been well established. Despite agreement on this point, there is still some degree of uncertainty regarding characteristics of the exposure-response relationship. The use of studies of underground miners to estimate lung cancer risks due to residential radon exposure depends upon a better understanding of factors potentially modifying the exposure-response relationship. Given the diversity in study populations regarding smoking status, mining conditions, risk analysis methodology, and referent populations, the risk estimates across studies are quite similar. However, several factors partially contributing to differences in risk estimates are modified by attained age, time since last exposure, exposure rate, and cigarette smoking patterns. There is growing agreement across studies that relative risk decreases with attained age and time since last exposure. Several studies have also found an inverse exposure-rate effect, i.e., low exposure rates for protracted duration of exposure are more hazardous than equivalent cumulative exposures received at higher rates for shorter periods of time. Additionally, the interaction between radon exposure and cigarette smoking appears to be intermediate between additive and multiplicative in a growing number of studies. Quantitative estimates of these modifying factors are given using a new analysis of data from the latest update of the Colorado Plateau uranium miners cohort.- Environ Health Perspect 1 03(Suppl 2):49-53 (1995)

  8. Journal of Biomechanics 40 (2007) 9931001 Pulmonary vascular remodeling in isolated mouse lungs

    E-Print Network [OSTI]

    Chesler, Naomi C.

    2007-01-01T23:59:59.000Z

    Journal of Biomechanics 40 (2007) 993­1001 Pulmonary vascular remodeling in isolated mouse lungs­flow relationships in mouse lungs and does so via structural remodeling. They also provide important baseline data

  9. Dr. Shih-Lung Shaw's Research on Space-Time GIS, Human Dynamics and Big Data

    E-Print Network [OSTI]

    Grissino-Mayer, Henri D.

    1 Dr. Shih-Lung Shaw's Research on Space-Time GIS, Human Dynamics and Big Data for Geography Department's Faculty Research Highlight October 12, 2014 Shih-Lung Shaw, Ph.D. Alvin and Sally Beaman

  10. The social evolution of Pseudomonas aeruginosa in the cystic fibrotic lung

    E-Print Network [OSTI]

    West, Stuart

    The social evolution of Pseudomonas aeruginosa in the cystic fibrotic lung Natalie Jiricny Christ in the cystic fibrotic lung 4 1.1.2 The siderophores of P. aeruginosa ­ the production of a public good 7 1

  11. Response and Resistance to NF-?B Inhibitors in Mouse Models of Lung Adenocarcinoma

    E-Print Network [OSTI]

    Xue, Wen

    Lung adenocarcinoma is a leading cause of cancer death worldwide. We recently showed that genetic inhibition of the NF-?B pathway affects both the initiation and the maintenance of lung cancer, identifying this pathway as ...

  12. Precision-cut lung slices: a novel model for respiratory tract toxicology

    E-Print Network [OSTI]

    Schwade, Lisa Schier

    1995-01-01T23:59:59.000Z

    emphasis on in vitro techniques for toxicologic research, the precision-cut lung slice model was extended to the mouse to determine the predictive value of this system for assessing interspecies differences in metabolism and toxicity. Validation of the lung...

  13. Precision-cut lung slices: a novel model for respiratory tract toxicology 

    E-Print Network [OSTI]

    Schwade, Lisa Schier

    1995-01-01T23:59:59.000Z

    emphasis on in vitro techniques for toxicologic research, the precision-cut lung slice model was extended to the mouse to determine the predictive value of this system for assessing interspecies differences in metabolism and toxicity. Validation of the lung...

  14. Spatiotemporal quantification of cell dynamics in the lung following influenza virus infection

    E-Print Network [OSTI]

    Yin, Lu

    Lung injury caused by influenza virus infection is widespread. Understanding lung damage and repair progression post infection requires quantitative spatiotemporal information on various cell types mapping into the tissue ...

  15. Major Shifts in the Spatio-Temporal Distribution of Lung Antioxidant Enzymes during Influenza Pneumonia

    E-Print Network [OSTI]

    Yamada, Yoshiyuki

    With the incessant challenge of exposure to the air we breathe, lung tissue suffers the highest levels of oxygen tension and thus requires robust antioxidant defenses. Furthermore, following injury or infection, lung tissue ...

  16. Quantification of Neuroepithelial Bodies and Their Innervation in Fawn-Hooded and Wistar Rat Lungs

    E-Print Network [OSTI]

    Burnstock, Geoffrey

    Quantification of Neuroepithelial Bodies and Their Innervation in Fawn-Hooded and Wistar Rat Lungs neuroendocrine system (DNES) of the lungs, the neuroendocrine cells of which have been shown to express

  17. Extracting k Most Important Groups from Data Efficiently Man Lung Yiu a

    E-Print Network [OSTI]

    Yiu, Man Lung

    Extracting k Most Important Groups from Data Efficiently Man Lung Yiu a , Nikos Mamoulis b.3 Optimization and Performance Contact Author: Man Lung Yiu #12;1. Introduction Aggregate queries summarize

  18. Program restructuring using clustering techniques Chung-Horng Lung a,*, Xia Xu a

    E-Print Network [OSTI]

    Lung, Chung-Horng

    Program restructuring using clustering techniques Chung-Horng Lung a,*, Xia Xu a , Marzia Zaman b. Tel.: +1 613 5202600; fax: +1 613 5205727. E-mail addresses: chlung@sce.carleton.ca (C.-H. Lung

  19. The early American motion picture industry: promoting American cultural hegemony

    E-Print Network [OSTI]

    Wier, Theresa Joanne

    1994-01-01T23:59:59.000Z

    : CULTURAL IMPERIALISM? Introduction Film as imperialism? Technology Cultural Imperialism Economic Trends Conclusion 67 67 69 72 74 79 81 Vl THE ADVENT OF SOUND 85 Introduction Europe Conclusion 85 95 99 VII CONCLUDING COMMENTS 100... classical imperialism to a new category of international exportation founded on the products of the second industrial revolution: steel, the internal combusion [sic] engine and electricity ? including motion pictures" (1980, 81). However, American...

  20. Perfusion lung scan: an aid in detection of lymphangitic carcinomatosis

    SciTech Connect (OSTI)

    Bates, S.E.; Tranum, B.L.

    1982-07-15T23:59:59.000Z

    Lymphangitic carcinomatosis is usually a late manifestation of metastatic disease. The patient usually presents with cough or dyspnea, and the chest radiograph is often nondiagnostic. Two patients are presented who developed symptoms while on adjuvant chemotherapy. Both had abnormal perfusion lung scans. One had matching ventilation defects; the other a normal ventilation study. Biopsy revealed metastatic carcinoma; in one case tumor was seen in both the pulmonary lymphatics and arterioles; in the other, tumor was identified but the site could not be specified. The radionuclide lung scan is a technique which can speed diagnosis and institution of therapy in lymphangitic carcinomatosis.

  1. Pulmonary Artery Pseudoaneurysm Related to Radiofrequency Ablation of Lung Tumor

    SciTech Connect (OSTI)

    Sakurai, Jun, E-mail: sakurai@cc.okayama-u.ac.jp; Mimura, Hidefumi; Gobara, Hideo; Hiraki, Takao; Kanazawa, Susumu [Okayama University Medical School, Department of Radiology (Japan)

    2010-04-15T23:59:59.000Z

    We describe a case of pulmonary artery (PA) pseudoaneurysm related to radiofrequency ablation (RFA) of lung tumor. We performed RFA for a pulmonary epithelioid hemangioendothelioma directly adjacent to a branch of the PA. Seventeen days later, the patient complained of hemoptysis. A chest CT image revealed PA pseudoaneurysm. Transcatheter coil embolization was performed 59 days after RFA. Although PA pseudoaneurysm is rare, with an incidence of 0.2% (1/538 sessions) at our institution, it should be recognized as a risk when treating lung tumors adjacent to a branch of the PA.

  2. Changes in Caribbean surface hydrography during the Pliocene shoaling of the Central American Seaway

    E-Print Network [OSTI]

    Gilli, Adrian

    Changes in Caribbean surface hydrography during the Pliocene shoaling of the Central American planktonic foraminifers from the Caribbean (Ocean Drilling Program sites 999 and 1000), the tropical east Bank) were used to examine Atlantic-Caribbean-Pacific atmospheric and oceanic linkages associated

  3. The Lung Image Database Consortium (LIDC) and Image Database Resource Initiative (IDRI): A Completed Reference Database of Lung Nodules on CT Scans

    SciTech Connect (OSTI)

    NONE

    2011-02-15T23:59:59.000Z

    Purpose: The development of computer-aided diagnostic (CAD) methods for lung nodule detection, classification, and quantitative assessment can be facilitated through a well-characterized repository of computed tomography (CT) scans. The Lung Image Database Consortium (LIDC) and Image Database Resource Initiative (IDRI) completed such a database, establishing a publicly available reference for the medical imaging research community. Initiated by the National Cancer Institute (NCI), further advanced by the Foundation for the National Institutes of Health (FNIH), and accompanied by the Food and Drug Administration (FDA) through active participation, this public-private partnership demonstrates the success of a consortium founded on a consensus-based process. Methods: Seven academic centers and eight medical imaging companies collaborated to identify, address, and resolve challenging organizational, technical, and clinical issues to provide a solid foundation for a robust database. The LIDC/IDRI Database contains 1018 cases, each of which includes images from a clinical thoracic CT scan and an associated XML file that records the results of a two-phase image annotation process performed by four experienced thoracic radiologists. In the initial blinded-read phase, each radiologist independently reviewed each CT scan and marked lesions belonging to one of three categories (''nodule{>=}3 mm,''''nodule<3 mm,'' and ''non-nodule{>=}3 mm''). In the subsequent unblinded-read phase, each radiologist independently reviewed their own marks along with the anonymized marks of the three other radiologists to render a final opinion. The goal of this process was to identify as completely as possible all lung nodules in each CT scan without requiring forced consensus. Results: The Database contains 7371 lesions marked ''nodule'' by at least one radiologist. 2669 of these lesions were marked ''nodule{>=}3 mm'' by at least one radiologist, of which 928 (34.7%) received such marks from all four radiologists. These 2669 lesions include nodule outlines and subjective nodule characteristic ratings. Conclusions: The LIDC/IDRI Database is expected to provide an essential medical imaging research resource to spur CAD development, validation, and dissemination in clinical practice.

  4. Mechanical Ventilation for Imaging the Small Animal Lung Laurence W. Hedlund and G. Allan Johnson

    E-Print Network [OSTI]

    Mechanical Ventilation for Imaging the Small Animal Lung Laurence W. Hedlund and G. Allan Johnson lung. Because me- chanical ventilation plays a key role in high-quality, high- resolution imaging of the small animal lung, the article focuses particularly on the problems of ventilation support, control

  5. Buccal oscillation and lung ventilation in a semi-aquatic turtle, Platysternon megacephalum

    E-Print Network [OSTI]

    Brainerd, Elizabeth

    Buccal oscillation and lung ventilation in a semi-aquatic turtle, Platysternon megacephalum Kelly A including feeding, lung ventilation, buccopharyngeal respiration, thermoregulation, olfaction, defense of these buccal oscillations is 7.8 times smaller than the mean tidal volume of lung ventilation (combined mean

  6. Lobe-based Estimating Ventilation and Perfusion from 3D CT scans of the Lungs

    E-Print Network [OSTI]

    Warren, Joe

    Lobe-based Estimating Ventilation and Perfusion from 3D CT scans of the Lungs Travis McPhail Joe are the ventilation (air flow) and perfusion (blood flow) in the patient's lungs. Given the flow of air and blood as possible. The current state of the art technology for assessing the ventilation in a patient's lungs

  7. Lung ventilation in vertebrates is accomplished by diverse respiratory pump mechanisms. Amniotes use an aspiration

    E-Print Network [OSTI]

    Brainerd, Elizabeth

    Lung ventilation in vertebrates is accomplished by diverse respiratory pump mechanisms. Amniotes primitive body form, and a recent study of lung ventilation in Necturus maculosus has suggested that studies). The mechanism of lung ventilation in N. maculosus is similar to the buccal pump used by lepidosirenid lungfishes

  8. Mathematical Modeling of the First Inflation of Degassed Lungs BELA SUKI,* JOSE S. ANDRADE, JR.,

    E-Print Network [OSTI]

    Stanley, H. Eugene

    Mathematical Modeling of the First Inflation of Degassed Lungs BE´LA SUKI,* JOSE´ S. ANDRADE, JR--The pressure­volume (P­V) relationship of de- gassed lungs during the first inflation is different from and degassed rabbit lungs. By fitting these data, we found that n 17 5, Plow 23 4 cmH2O

  9. Attenuation of tobacco smoke-induced lung inflammation by treatment with a soluble epoxide

    E-Print Network [OSTI]

    Hammock, Bruce D.

    Attenuation of tobacco smoke-induced lung inflammation by treatment with a soluble epoxide, December 21, 2004 Changes in the lungs due to smoking include inflammation, epi- thelial damage inflammation in the lungs. Soluble epoxide hydrolases (sEH) are enzymes that add water to epoxides forming

  10. Massive Hemoptysis from Pulmonary Artery Pseudoaneurysm Caused by Lung Radiofrequency Ablation: Successful Treatment by Coil Embolization

    SciTech Connect (OSTI)

    Yamakado, Koichiro, E-mail: yama@clin.medic.mie-u.ac.jp; Takaki, Haruyuki [Mie University School of Medicine, Department of Radiology (Japan); Takao, Motoshi [Mie University School of Medicine, Department of Thoracic Surgery (Japan); Murashima, Shuichi; Kodama, Hiroshi; Kashima, Masataka; Nakatsuka, Atsuhiro; Uraki, Junji [Mie University School of Medicine, Department of Radiology (Japan); Shimpo, Hideto [Mie University School of Medicine, Department of Thoracic Surgery (Japan); Takeda, Kan [Mie University School of Medicine, Department of Radiology (Japan)

    2010-04-15T23:59:59.000Z

    A 75-year-old man received lung radiofrequency (RF) ablation to treat lung metastases from hepatocellular carcinoma. Massive hemoptysis occurred 1 week after lung RF ablation. Emergent contrast-enhanced CT and pulmonary arteriography revealed a pulmonary artery pseudoaneurysm, which was embolized with coils. The postembolization course was uneventful. Hemoptysis did not recur for 5 months.

  11. Close Mimicry of Lung Surfactant Protein B by ``Clicked'' Dimers of Helical, Cationic Peptoids

    E-Print Network [OSTI]

    Barron, Annelise E.

    Close Mimicry of Lung Surfactant Protein B by ``Clicked'' Dimers of Helical, Cationic Peptoids-protein mixture that lines the air-liquid (a/l) interface of vertebrate lungs and varies surface tension (c, mN m, maximizes lung Michelle T. Dohm and Shannon L. Seurynck-Servoss contributed equally to this work. Contract

  12. Ultrafast MR Grid-Tagging Sequence for Assessment of Local Mechanical Properties of the Lungs

    E-Print Network [OSTI]

    Napadow, Vitaly

    Ultrafast MR Grid-Tagging Sequence for Assessment of Local Mechanical Properties of the Lungs Qun in MR imaging of lung parenchyma. In this study, a fast MR grid-tagging technique is described deformation of the lung. Quantitative analysis of the data shows that this method is capable of assessing

  13. Use of Lung Transplantation Survival Models to Refine Patient Selection in Cystic Fibrosis

    E-Print Network [OSTI]

    Adler, Fred

    Use of Lung Transplantation Survival Models to Refine Patient Selection in Cystic Fibrosis Theodore Angeles, California Lung transplantation in cystic fibrosis may improve survival for patients with low 5 and United Network for Organ Sharing data, we identified 845 lung transplant recipients from 1991

  14. Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines

    E-Print Network [OSTI]

    Immunity Article Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines 2 (Th2) cells in the lung is thought to be a cause of asthma. Here we report that innate lymphocytes termed lung natural helper (LNH) cells are a T cell-independent source of Th2 cell-type cytokines

  15. Increased lung cancer risks are similar whether arsenic is ingested ALLAN H. SMITHa

    E-Print Network [OSTI]

    California at Berkeley, University of

    Increased lung cancer risks are similar whether arsenic is ingested or inhaled ALLAN H. SMITHa that inorganic arsenic was a human lung carcinogen based on studies involving exposure through inhalation. In 2004, IARC listed arsenic in drinking water as a cause of lung cancer, making arsenic the first

  16. 26 UniPress 160/2014 Forschung Wenn Nanopartikel in der Lunge landen

    E-Print Network [OSTI]

    Richner, Heinz

    26 UniPress 160/2014 Forschung Wenn Nanopartikel in der Lunge landen Die Nanotechnologie ist ­ mit einem Gerät, das die menschliche Lunge nachahmt. Von Susanne Wenger Ein unscheinbarer Raum im Nano- partikeln auf die menschliche Lunge unter- sucht werden soll. Nanopartikel sind ultrakleine

  17. Real-Time Investigation of Lung Surfactant Respreading with Surface Vibrational Spectroscopy

    E-Print Network [OSTI]

    Real-Time Investigation of Lung Surfactant Respreading with Surface Vibrational Spectroscopy Gang, Columbus, Ohio 43210 ReceiVed May 24, 2006. In Final Form: September 22, 2006 The respreading of a lung (BBSFG) spectroscopy. The lung surfactant mixture contains chain perdeuterated

  18. Biophysical Mimicry of Lung Surfactant Protein B by Random Nylon-3 Copolymers

    E-Print Network [OSTI]

    Barron, Annelise E.

    Biophysical Mimicry of Lung Surfactant Protein B by Random Nylon-3 Copolymers Michelle T. Dohm as functional analogues of lung surfactant proteins B and C (SP-B and SP-C), two helical and amphiphilic evidence that sequence-random copolymers can mimic the in vitro surface-active behavior of lung surfactant

  19. Mathematical model of a three-stage innate immune response to a pneumococcal lung infection

    E-Print Network [OSTI]

    Adler, Fred

    Mathematical model of a three-stage innate immune response to a pneumococcal lung infection Amber M in the lung: resident alveolar macrophages, neutrophils and monocyte-derived macrophages. The alveolar migrate to the lungs resulting in a more serious infection. Nevertheless, only a small fraction

  20. LETTER doi:10.1038/nature13173 Reconstructing lineage hierarchies of the distal lung

    E-Print Network [OSTI]

    Quake, Stephen R.

    LETTER doi:10.1038/nature13173 Reconstructing lineage hierarchies of the distal lung epithelium The mammalian lung is a highly branched network in which the distal regions of the bronchial tree transform-mapping, the mechanisms that control the progression of lung progenitors along distinct lineages into mature alveolar cell

  1. Loss of Social Behaviours in Populations of Pseudomonas aeruginosa Infecting Lungs of Patients with Cystic

    E-Print Network [OSTI]

    West, Stuart

    Loss of Social Behaviours in Populations of Pseudomonas aeruginosa Infecting Lungs of Patients persistent and frequently fatal infections of the lung in patients with cystic fibrosis. Isolates from and this is widely interpreted as the result of adaptation to the lung environment. Typically, chronic strains carry

  2. Lung Health Dissertation Grant (LH) Program Description Page 1 of 6 5/25/2011

    E-Print Network [OSTI]

    Gleeson, Joseph G.

    Lung Health Dissertation Grant (LH) Program Description Page 1 of 6 5/25/2011 IMPORTANT NOTES REFERENCE. The objective of the Lung Health Research Dissertation Grant is to support pre-doctoral dissertation research in the various disciplines of social science examining risk factors affecting lung health

  3. DEPARTMENT OF DEFENSE LUNG CANCER RESEARCH PROGRAM FISCAL YEAR 2013 STRATEGIC PLAN

    E-Print Network [OSTI]

    von der Heydt, Rüdiger

    DEPARTMENT OF DEFENSE LUNG CANCER RESEARCH PROGRAM FISCAL YEAR 2013 STRATEGIC PLAN The Fiscal Year 2013 (FY13) Defense Appropriations Act provides for $10.5 million to the Department of Defense Lung Cancer Research Program (LCRP) to support innovative, high- impact lung cancer research. This program

  4. Allometric scaling of lung volume and its consequences for marine turtle diving performance

    E-Print Network [OSTI]

    Hays, Graeme

    Allometric scaling of lung volume and its consequences for marine turtle diving performance Sandra in revised form 15 May 2007; accepted 15 May 2007 Available online 21 May 2007 Abstract Marine turtle lungs have multiple functions including respiration, oxygen storage and buoyancy regulation, so lung size

  5. Lung collapse among aquatic reptiles and amphibians during long-term diving

    E-Print Network [OSTI]

    Brainerd, Elizabeth

    Lung collapse among aquatic reptiles and amphibians during long-term diving Gordon R. Ultscha requirements, but serves to keep lungs inflated that would otherwise collapse during prolonged submergence. We also suggest that lung deflation is routine in hibernating aquatic reptiles and amphibians

  6. Lung Cancer Discovery Award (LCD) Program Description Page 1 of 7 5/25/2011

    E-Print Network [OSTI]

    Gleeson, Joseph G.

    Lung Cancer Discovery Award (LCD) Program Description Page 1 of 7 5/25/2011 IMPORTANT NOTES REFERENCE. The Lung Cancer Discovery Award supports the development of novel medical treatments, advancing current treatment options and/or finding a cure for lung cancer through clinical, laboratory

  7. Mechanical interactions between collagen and proteoglycans: implications for the stability of lung tissue

    E-Print Network [OSTI]

    Alencar, Adriano Mesquita

    Mechanical interactions between collagen and proteoglycans: implications for the stability of lung- tions for the stability of lung tissue. J Appl Physiol 98: 672­679, 2005. First published September 24- ticity of the connective tissue including lung parenchyma. The gly- cosaminoglycans on the proteoglycans

  8. Acoustic evidence of airway opening during recruitment in excised dog lungs Z. Hantos,1

    E-Print Network [OSTI]

    Alencar, Adriano Mesquita

    Acoustic evidence of airway opening during recruitment in excised dog lungs Z. Hantos,1 J. Tolnai,1. Majumdar, and B. Suki. Acoustic evidence of airway opening during recruitment in excised dog lungs. J Appl-volume curve in the normal lung are primarily determined by airway reopen- ings via avalanches rather than

  9. ccsd-00004040,version1-24Jan2005 Polarized Helium to Image the Lung

    E-Print Network [OSTI]

    ccsd-00004040,version1-24Jan2005 Polarized Helium to Image the Lung Mich`ele Leduc and Pierre Jean Paris1 Abstract The main findings of the european PHIL project (Polarised Helium to Image the Lung diffusion. Diffusion imaging appears as a robust method of lung diagnosis. A discussion of the potential

  10. Assessment of morphometry of pulmonary acini in mouse lungs by nondestructive imaging using

    E-Print Network [OSTI]

    Wang, Ge

    Assessment of morphometry of pulmonary acini in mouse lungs by nondestructive imaging using a more complete understanding of the relationship of lung structure and function. We combined a special to separate individual acini in the mouse lung. Interior scans of the parenchyma at a resolution of 2 µm

  11. Original article Expression and activity of N-myristoyltransferase in lung

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Original article Expression and activity of N-myristoyltransferase in lung inflammation of cattle and inflamed lungs of the cattle are unknown. Therefore, we investigated the expression and activity of NMT in a bovine model of lung inflammation induced with Mannheimia hemolytica and in vitro in neutrophils

  12. AN INTEGRATED LUNG-ON-A-CHIP MICROFLUIDIC PLATFORM WITH REAL-TIME BIOCHEMICAL SENSING

    E-Print Network [OSTI]

    Kassegne, Samuel Kinde

    AN INTEGRATED LUNG-ON-A-CHIP MICROFLUIDIC PLATFORM WITH REAL-TIME BIOCHEMICAL SENSING, without finding it. ­ Lucius Annaeus Seneca #12;v ABSTRACT OF THE THESIS An Integrated Lung for detection. In this research, we replicate the Lung-on- a-Chip platform with a cystic fibrosis cell line

  13. Simulation of Lung Behaviour with Finite Elements : Inuence of Bio-Mechanical Parameters

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Simulation of Lung Behaviour with Finite Elements : Inuence of Bio-Mechanical Parameters Pierre by medical needs, we propose to simu- late lung deformation and motion during respiration to track tumours. This paper presents a model of lung behaviour based on a continuous media mechan- ics model and solved

  14. Lung and alveolar wall elastic and hysteretic behavior in rats: effects of in vivo elastase treatment

    E-Print Network [OSTI]

    Lutchen, Kenneth

    Lung and alveolar wall elastic and hysteretic behavior in rats: effects of in vivo elastase P. Ingenito, and Be´la Suki. Lung and alveolar wall elastic and hysteretic behavior in rats: effects behavior of the alveolar walls and the macroscopic mechanical properties of the whole lung in an in vivo

  15. Magnetic Resonance in Medicine 000:000000 (2011) Quantitative Analysis of Tumor Burden in Mouse Lung

    E-Print Network [OSTI]

    Nehorai, Arye

    2011-01-01T23:59:59.000Z

    Lung via MRI Vanessa K. Tidwell,1 Joel R. Garbow,2 Alexander S. Krupnick,3 John A. Engelbach,2 and Arye Nehorai1 Lung cancer is the leading cause of cancer death in the United States. Despite recent advances. Preclinical rodent models provide a unique opportu- nity to test novel therapeutic drugs for targeting lung

  16. ForPeerReview High Kallikrein-Related Peptidase 6 in Non-Small Cell Lung

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    ForPeerReview High Kallikrein-Related Peptidase 6 in Non-Small Cell Lung Cancer Cells: an indicator-4934.2009.00763.x #12;ForPeerReview 1 Research Paper High Kallikrein-Related Peptidase 6 in Non-Small Cell Lung in the development and dissemination of lung cancer, the leading cause of cancer mortality worldwide. We have

  17. Using a priori knowledge to classify in vivo images of the lung

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Using a priori knowledge to classify in vivo images of the lung Chesner D´esir1 , Caroline perspectives for this very challenging medical application. 1 Introduction The lungs are the essential, that includes the trachea, bronchi, and bronchioles, and (ii) the gas-exchange region, or lung parenchyma, made

  18. Decreased Lung Fibroblast Growth Factor 18 and Elastin in Congenital Diaphragmatic Hernia and Models

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Decreased Lung Fibroblast Growth Factor 18 and Elastin in Congenital Diaphragmatic Hernia,version1 HAL author manuscript #12;1 Abstract Rationale: Lung hypoplasia in congenital diaphragmatic of treatments. Methods: Human CDH and control lungs were collected post-mortem. Diaphragmatic hernia was created

  19. MOVEMENT OF WATER AND PROTEIN IN THE FETAL AND NEWBORN LUNG

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    MOVEMENT OF WATER AND PROTEIN IN THE FETAL AND NEWBORN LUNG R.D. BLAND, D.D. McMILLAN M.A. BRESSACK demonstrate that the fetal lung is not the dormant organ physiologists once thought it was. While it receives 14201 and HL 19185 and by a grant from the California Lung Associa- tion. Dr. McMillan received support

  20. SCENARIOS OF FUTURE LUNG CANCER INCIDENCE BY EDUCATIONAL LEVEL: MODELLING STUDY IN DENMARK

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 SCENARIOS OF FUTURE LUNG CANCER INCIDENCE BY EDUCATIONAL LEVEL: MODELLING STUDY IN DENMARK Gwenn : 10.1016/j.ejca.2010.07.027 #12;2 Abstract Objective: To model future trends in lung cancer incidence in Denmark by education under different scenarios for cigarette smoking. Methods: Lung cancer incidence until