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We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

alzheimers disease amyloid: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Alzheimer???s Disease Medications. Open Access Theses and Dissertations Summary: ??The brain of Alzheimer???s disease (AD) is characterized by accumulations of ??-amyloid peptide...

2

alzheimer disease amyloid: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Alzheimer???s Disease Medications. Open Access Theses and Dissertations Summary: ??The brain of Alzheimer???s disease (AD) is characterized by accumulations of ??-amyloid peptide...

3

New Clues in Predicting Alzheimer's Disease  

ScienceCinema (OSTI)

Theres a new clue in the search to identify the harbingers of Alzheimers disease. More info: http://newscenter.lbl.gov/feature-stories/2008/12/16/predict-alzheimers-disease/

Jagust, William

2013-05-29T23:59:59.000Z

4

alzheimer's disease: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and memory deterioration, a clinical hallmark of Alzheimer's disease that the primary factor in the pathogenesis of cognitive de ciencies in Alzheimer's disease is the...

5

Why Do We Get Alzheimer's Disease?  

SciTech Connect (OSTI)

Neurodegenerative diseases and Alzheimer's disease (AD) in particular, are among the major health concerns of the elderly in industrialized societies. The cause of AD is unknown and no disease-modifying treatments are available. The disease is characterized clinically by a progressive dementia and pathologically by the accumulation of protein aggregates in the brain and a profound loss of nerve cells. It has also become clear recently that local immune responses are activated in the AD brain and may have a role in the disease. Our laboratory uses genetic mouse models to understand the disease process and to identify potential therapeutic targets.

Wyss-Coray, Tony (Stanford University) [Stanford University

2006-01-02T23:59:59.000Z

6

Measuring Dementia of the Alzheimer Type More Precisely  

E-Print Network [OSTI]

in clinical research may be inappropriate for these populations. The Alzheimer Disease Assessment Scale-cognitive (ADAS-cog), a commonly used cognitive battery in AD research, is most sensitive in the moderate range of cognitive impairment. It focuses...

Lowe, Deborah Anne

2012-11-29T23:59:59.000Z

7

Journal of Alzheimer's Disease xx (20xx) xxx DOI 10.3233/JAD-132483  

E-Print Network [OSTI]

and Alzheimer's Disease as isoprostanes, neuroprostanes, acrolein, and hydrox- ynonenal (HNE), have also been

Mandal, Pravat K.

8

E-Print Network 3.0 - alzheimers disease caregivers Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

group for family caregivers and health... professionals The Alzheimer List is a free public service of the Alzheimer's Disease Research Center (ADRC... -mail based support...

9

alzheimers disease neuroimaging: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Learning Brain Connectivity of Alzheimer's Disease from Neuroimaging Data Mathematics Websites...

10

BONE LOSS IN RELATION TO HYPOTHALAMIC ATROPHY IN ALZHEIMER'S DISEASE  

E-Print Network [OSTI]

considerable burden on the health system, patients, and caregivers. 1.2 Alzheimer’s Disease and Bone Loss Bone health is an important issue in aging and AD. Osteoporosis–related fractures are among the major health and socioeconomic concerns in aging... of bone fractures, and a determining factor in clinical diagnosis of osteoporosis (Ammann and Rizzoli 2003). Several studies in women suggest that low BMD is associated with poorer cognitive function and subsequent cognitive decline (Yaffe, Browner et al...

Loskutova, Natalia Y.

2011-05-12T23:59:59.000Z

11

E-Print Network 3.0 - alzheimers disease ad Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sample search results for: alzheimers disease ad Page: << < 1 2 3 4 5 > >> 1 4.2.5 NANOTECHNOLOGY TOWARDS CLINICAL DIAGNOSIS OF ALZHEIMER'S DISEASE D. Georganopoulu, L. Chang,...

12

Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla  

E-Print Network [OSTI]

Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla and Alzheimer's disease based on high resolution MRI at 3 Tesla. T1-weighted images were acquired from 19

Thompson, Paul

13

alzheimer disease brain: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

alzheimer disease brain First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Brain MRI segmentation for the...

14

Atlas-Based Hippocampus Segmentation In Alzheimer's Disease and Mild  

E-Print Network [OSTI]

Atlas-Based Hippocampus Segmentation In Alzheimer's Disease and Mild Cognitive Impairment Owen T of Chen to align the images to the Harvard atlas, MNI atlas, and randomly-selected, manually state, registration method, choice of atlas, and man- ual tracing protocol on the agreement between

15

Learning Brain Connectivity of Alzheimer's Disease from Neuroimaging Data  

E-Print Network [OSTI]

Learning Brain Connectivity of Alzheimer's Disease from Neuroimaging Data Shui Huang2 , Jing Li2 to alternation in the functional brain network, i.e., the functional connectivity among different brain regions. In this paper, we consider the problem of learning functional brain connectivity from neuroimaging, which holds

Li, Jing

16

E-Print Network 3.0 - alzheimers disease brain Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

September... disease other than incipient Alzheimer's disease, any history of significant brain lesions or head trauma... ... Source: Thompson, Paul - Laboratory of Neuro Imaging,...

17

Utilization of Fibroblast Steroidogeic Capacity as a Predictive Marker for Alzheimer's Disease  

E-Print Network [OSTI]

the cause of AD must be related to aging · Figure 1. Sex Hormone Dyscrasia Following Menopause Post, including coronary heart disease, stroke, Alzheimer's disease and osteoporosis. Since circulating

Wisconsin at Madison, University of

18

A Novel Sensitive Method of Detecting Mnemonic Decline in Mouse Model of Alzheimer's Disease  

E-Print Network [OSTI]

of the requirements for the designation as UNDERGRADUATE RESEARCH SCHOLAR A Junior Scholars Thesis by REBECCA KAYE SIMMONS A NOVEL SENSITIVE METHOD OF DETECTING MNEMONIC DECLINE IN MOUSE MODEL OF ALZHEIMER?S DISEASE Approved by: Research... as UNDERGRADUATE RESEARCH SCHOLAR A Junior Scholars Thesis by REBECCA KAYE SIMMONS iii ABSTRACT A Novel Sensitive Method of Detecting Mnemonic Decline in Mouse Models of Alzheimer?s Disease. (April 2009) Rebecca Kaye Simmons Department of Psychology...

Simmons, Rebecca

2011-01-11T23:59:59.000Z

19

E-Print Network 3.0 - alzheimer disease molecular Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of Earth and Environmental Sciences, Wesleyan University Collection: Geosciences 2 COGNITIVE NEUROLOGY AND ALZHEIMER'S DISEASE CENTER Summary: CNADC COGNITIVE NEUROLOGY AND...

20

Gist Memory in Alzheimer's Disease: Evidence From Categorized Pictures Andrew E. Budson  

E-Print Network [OSTI]

Gist Memory in Alzheimer's Disease: Evidence From Categorized Pictures Andrew E. Budson Edith of items (gist memory; Reyna & Brainerd, 1995; Schacter, Norman, & Koutstaal, 1998). We have argued

Schacter, Daniel

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Towards an Objective Assessment of Alzheimer's Disease: The Application of a Novel Evolutionary Algorithm  

E-Print Network [OSTI]

the way out of a large building. It also affects the drawing of simple three- dimensional geometric shapes countries [4]. The disease occurs when the amyloid -protein forms miliary bodies (plaques) and dense bundles conclusions are drawn in Section 5. 2. ALZHEIMER'S DISEASE Alzheimer's disease (AD) is the most common form

Fernandez, Thomas

22

Iron and aluminum interaction with amyloid-beta peptides associated with Alzheimer’s disease  

SciTech Connect (OSTI)

An elevation in the concentration of heavy metal ions in Alzheimer’s disease (AD) brain has been demonstrated in many studies. A? precipitation and toxicity in AD brains seem to be caused by abnormal interactions with neocortical metal ions, especially iron, copper, zinc, and aluminum [1–3]. There is increasing evidence that iron and aluminum ions are involved in the mechanisms that underlie the neurodegenerative diseases [4,5]. However, evidence was brought to demonstrate that some A? fragments, at physiological pH, are not able to form binary complexes with Fe(III) ions of sufficient stability to compete with metal hydroxide precipitation [6]. On the contrary, multiple metal ions are known to interact with A? peptides [7]. Consequently, we investigated here the interaction of Fe(II/III) and Al(III) ions with some amyloid-? peptides and fragments that results in peptide aggregation and fibrillation [8,9]. Infrared spectroscopy, atomic force microscopy, scanning electron microscopy, electrophoresis and mass spectrometry demonstrated conformational changes of peptides in the presence of such metals.

Drochioiu, Gabi; Ion, Laura [Alexandru Ioan Cuza University of Iasi, 11 Carol I, Iasi 700506 (Romania); Murariu, Manuela; Habasescu, Laura [Petru Poni Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, Iasi 700487 (Romania)

2014-10-06T23:59:59.000Z

23

Foundation for the Support of Research on Alzheimer's Disease and other Neurodegenerative Diseases Synapsis Foundation, Fabrikstrasse 50, CH-8031 Zrich  

E-Print Network [OSTI]

Foundation for the Support of Research on Alzheimer's Disease and other Neurodegenerative Diseases Synapsis Foundation, Fabrikstrasse 50, CH-8031 Zürich Tel. +41 (0)44 271 35 11, Fax +41 (0)44 271 35 12 Submission Deadline 31st August, 2011 SYNAPSIS FOUNDATION with its research programme "Alzheimer Research

Richner, Heinz

24

Innovative Alzheimer's disease clinical trial design in the coming age of biomarkers  

E-Print Network [OSTI]

Alzheimer's disease (AD) is a field with huge unmet need and only a few symptomatic treatments with limited efficacy have been made available to patients. With the testing of disease-modifying drugs in recent years, the ...

Hillerstrom, Hampus

2008-01-01T23:59:59.000Z

25

Metabonomic Profiling of TASTPM Transgenic Alzheimer's Disease Mouse Model  

SciTech Connect (OSTI)

Identification of molecular mechanisms underlying early stage Alzheimer’s disease (AD) is important for the development of new therapies against and diagnosis of AD. In this study, non-targeted metabotyping of TASTPM transgenic AD mice was performed. The metabolic profiles of both brain and plasma of TASTPM mice were characterized using gas chromatography-mass spectrometry and compared to those of wild type C57BL/6J mice. TASTPM mice were metabolically distinct compared to wild type mice (Q28 Y = 0.587 and 0.766 for PLS-DA models derived from brain and plasma, respectively). A number of metabolites were found to be perturbed in TASTPM mice in both brain (D11 fructose, L-valine, L-serine, L-threonine, zymosterol) and plasma (D-glucose, D12 galactose, linoleic acid, arachidonic acid, palmitic acid and D-gluconic acid). In addition, enzyme immunoassay confirmed that selected endogenous steroids were significantly perturbed in brain (androstenedione and 17-OH-progesterone) and plasma (cortisol and testosterone) of TASTPM mice. Ingenuity pathway analysis revealed that perturbations related to amino acid metabolism (brain), steroid biosynthesis (brain), linoleic acid metabolism (plasma) and energy metabolism (plasma) accounted for the differentiation of TASTPM and wild-type

Hu, Zeping; Browne, Edward R.; Liu, Tao; Angel, Thomas E.; Ho, Paul C.; Chun Yong Chan, Eric

2012-12-07T23:59:59.000Z

26

Nanoimaging to Prevent and Treat Alzheimer’s and Parkinson’s Diseases. Scientific/Technical report  

SciTech Connect (OSTI)

This project will develop innovative approaches to characterization of the very early stages of protein aggregation that eventually can be translated to the development of early diagnostic tools and efficient treatments for Alzheimer’s, Parkinson’s and Huntington’s diseases. Funding will be used to acquire nanoimaging technology for nanoscale imaging, manipulation and analysis of biomedical materials to develop treatments that will repair disabled proteins and cure diseases that result from protein malfunction, specifically Alzheimer’s and Parkinson’s diseases. Expected outcomes include tests for early diagnosis and therapeutic treatments for these devastating neurological diseases. To elucidate the mechanisms of protein misfolding, we will establish an extensive program of experimental studies using a broad arsenal of advanced nanoscale and traditional techniques that will be integrated with molecular-scale modeling of protein misfolding and the nucleation of aggregate structures. To identify intracellular machinery or/and multicomponent complexes critically involved in protein misfolding, we will characterize interactions between targeted proteins and specific intracellular components or metabolites that impact on protein conformational pathways leading to protein misfolding accompanied by formation of toxic aggregated morphologies. To design innovative nanotechnology tools for the control of intracellular protein misfolding and aggregation processes, we will develop a predictive molecular scale model for intracellular protein misfolding and the formation of toxic aggregates. Verified through experimental studies, the objective is to establish an enabling foundation for the engineering of novel molecular diagnostics and therapeutics for various cellular pathologies.

Yuri L. Lyubchenko, PhD, DSc

2012-12-20T23:59:59.000Z

27

E-Print Network 3.0 - alzheimers disease patients Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

in brain size, indicated by the white areas... by awareness of growing debility and lost in a fog of confusion. At that time, Alzheimer's disease was rarely... away," says...

28

E-Print Network 3.0 - alzheimer disease patients Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

in brain size, indicated by the white areas... by awareness of growing debility and lost in a fog of confusion. At that time, Alzheimer's disease was rarely... away," says...

29

alzheimer amyloid peptide: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Alzheimer???s Disease Medications. Open Access Theses and Dissertations Summary: ??The brain of Alzheimer???s disease (AD) is characterized by accumulations of ??-amyloid peptide...

30

alzheimer disease brains: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Brain MRI segmentation for the longitudinal follow-up of regional atrophy in Alzheimers...

31

Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients  

SciTech Connect (OSTI)

Mitochondrial DNA (mtDNA) variants associated with Alzheimer disease (AD) and Parkinson disease (PD) were sought by restriction endonuclease analysis in a cohort of 71 late-onset Caucasian patients. A tRNA[sup Gln] gene variant at nucleotide pair (np) 4336 that altered a moderately conserved nucleotide was present in 9/173 (5.2%) of the patients surveyed but in only 0.7% of the general Caucasian controls. One of these patients harbored an additional novel 12S rRNA 5-nucleotide insertion at np 956-965, while a second had a missense variant at np 3397 that converted a highly conserved methionine to a valine. This latter mutation was also found in an independent AD + PD patient, as was a heteroplasmic 16S rRNA variant at np 3196. Additional studies will be required to determine the significance, if any, of these mutations. 122 refs., 4 figs., 2 tabs.

Shoffner, J.M.; Brown, M.D.; Torroni, A.; Lott, M.T.; Cabell, M.F.; Mirra, S.S.; Yang, C.C.; Gearing, M.; Salvo, R. (Emory Univ. School of Medicine, Atlanta, GA (United States)); Beal, M.F. (Harvard Medical School, Boston, MA (United States)) (and others)

1993-07-01T23:59:59.000Z

32

Aluminum and silica intake in drinking water and the risk of Alzheimer's disease or cognitive decline: findings of the  

E-Print Network [OSTI]

Aluminum and silica intake in drinking water and the risk of Alzheimer's disease or cognitive,2 , Commenges Daniel1,2 , Helmer Catherine2,3 , Jean-François Dartigues2,3 . Abbreviations: Al, Aluminum; AD, Alzheimer's Disease; MMSE, Mini Mental State Examination; Si, Silica Running head: Aluminum, silica in water

Paris-Sud XI, Université de

33

BrainPrint in the Computer-Aided Diagnosis of Alzheimer's Disease  

E-Print Network [OSTI]

BrainPrint in the Computer-Aided Diagnosis of Alzheimer's Disease C. Wachinger1,2 , K cognitive impairment. We employ BrainPrint to obtain an extensive characterization of the shape of brain structures. BrainPrint captures shape information of an ensemble of cortical and subcortical structures

Golland, Polina

34

Label-Free Quantitative LC?MS Proteomics of Alzheimer’s Disease and Normally Aged Human Brains  

SciTech Connect (OSTI)

Quantitative proteomics analysis of cortical samples of 10 Alzheimer’s disease (AD) brains versus 10 normally aged brains was performed by following the accurate mass and time tag (AMT) approach with the high resolution LTQ Orbitrap mass spectrometer. More than 1400 proteins were identified and quantitated. A conservative approach of selecting only the consensus results of four normalization methods was suggested and used. A total of 197 proteins were shown to be significantly differentially abundant (p-values <0.05, corrected for multiplicity of testing) in AD versus control brain samples. Thirty-seven of these proteins were reported as differentially abundant or modified in AD in previous proteomics and transcriptomics publications. The rest to the best of our knowledge are new. Mapping of the discovered proteins with bioinformatic tools revealed significant enrichment with differentially abundant proteins of pathways and processes known to be important in AD, including signal transduction, regulation of protein phosphorylation, immune response, cytoskeleton organization, lipid metabolism, energy production, and cell death.

Andreev, Victor P.; Petyuk, Vladislav A.; Brewer, Heather M.; Karpievitch, Yuliya; Xie, Fang; Clarke, Jennifer; Camp, David G.; Smith, Richard D.; Lieberman, Andrew P.; Albin, Roger L.; Nawaz, Zafar; Hokayem, Jimmy E.; Myers, Amanda J.

2012-06-17T23:59:59.000Z

35

ADA Retrofit and Construction  

E-Print Network [OSTI]

ADA Retrofit and Construction Management Richfield, MN Breckenridge, MN #12;Introduction & Outline Design vs. Construction § Case Studies § City of Richfield's Transition Plan #12;How Detailed Should, MN #12;Case Study Breckenridge, MN #12;§ Construction Plans § Intersection Details for "tough

Minnesota, University of

36

Correlates of Hippocampal Neuron Number in Alzheimer's Disease and Ischemic  

E-Print Network [OSTI]

White, MD,6 and Helena C. Chui, MD7 The cornu ammonis 1 region of the hippocampus (CA1) sector-vessel disease, and leukoariosis.1 The cornu ammonis 1 region of the hippocampus (CA1) sector of hippocampus

California at Davis, University of

37

3D Local Binary Pattern for PET image classification by SVM Application to early Alzheimer disease diagnosis  

E-Print Network [OSTI]

3D Local Binary Pattern for PET image classification by SVM Application to early Alzheimer disease of Fluorodeoxyglucose PET scans might become a possibility to make early diagnosis more efficient. Temporal and parietal lobes are the main location of medical findings. We have clues that in PET images these lobes contain

Paris-Sud XI, Université de

38

AUTOMATIC CLASSIFICATION OF ALZHEIMER'S DISEASE VS. FRONTOTEMPORAL DEMENTIA: A SPATIAL DECISION TREE APPROACH WITH FDG-PET  

E-Print Network [OSTI]

TREE APPROACH WITH FDG-PET N. Sadeghi1 , N. L. Foster2 , A. Y. Wang2 , S. Minoshima3 , A. P. Lieberman4 48109 ABSTRACT We introduce a novel approach for the automatic classifica- tion of FDG-PET scans-- Brain imaging, decision tree, FDG-PET, Alzheimer's Disease, Frontotemporal dementia. 1. INTRODUCTION

Utah, University of

39

Proteomic profiling of brain cortex tissues in a Tau transgenic mouse model of Alzheimer's disease  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer A transgenic mouse model expressing NSE-htau23 was used. Black-Right-Pointing-Pointer 2D-gel electrophoresis to analyze the cortex proteins of transgenic mice was used. Black-Right-Pointing-Pointer Differentially expressed spots in different stages of AD were identified. Black-Right-Pointing-Pointer GSTP1 and CAII were downregulated with the progression of AD. Black-Right-Pointing-Pointer SCRN1 and ATP6VE1 were up regulated and down regulated differentially. -- Abstract: Alzheimer's disease (AD) involves regionalized neuronal death, synaptic loss, and an accumulation of intracellular neurofibrillary tangles and extracellular senile plaques. Although there have been numerous studies on tau proteins and AD in various stages of neurodegenerative disease pathology, the relationship between tau and AD is not yet fully understood. A transgenic mouse model expressing neuron-specific enolase (NSE)-controlled human wild-type tau (NSE-htau23), which displays some of the typical Alzheimer-associated pathological features, was used to analyze the brain proteome associated with tau tangle deposition. Two-dimensional electrophoresis was performed to compare the cortex proteins of transgenic mice (6- and 12-month-old) with those of control mice. Differentially expressed spots in different stages of AD were identified with ESI-Q-TOF (electrospray ionization quadruple time-of-flight) mass spectrometry and liquid chromatography/tandem mass spectrometry. Among the identified proteins, glutathione S-transferase P 1 (GSTP1) and carbonic anhydrase II (CAII) were down-regulated with the progression of AD, and secerin-1 (SCRN1) and V-type proton ATPase subunit E 1 (ATP6VE1) were up-regulated only in the early stages, and down-regulated in the later stages of AD. The proteins, which were further confirmed by RT-PCR at the mRNA level and with western blotting at the protein level, are expected to be good candidates as drug targets for AD. The study of up- and down-regulation of proteins during the progression of AD helps to explain the mechanisms associated with neuronal degeneration in AD.

Chang, Seong-Hun; Jung, In-Soo; Han, Gi-Yeon; Kim, Nam-Hee; Kim, Hyun-Jung [School of Life Sciences and Biotechnology, Korea University, Seoul 136-701 (Korea, Republic of)] [School of Life Sciences and Biotechnology, Korea University, Seoul 136-701 (Korea, Republic of); Kim, Chan-Wha, E-mail: cwkim@korea.ac.kr [School of Life Sciences and Biotechnology, Korea University, Seoul 136-701 (Korea, Republic of)] [School of Life Sciences and Biotechnology, Korea University, Seoul 136-701 (Korea, Republic of)

2013-01-11T23:59:59.000Z

40

Key residues for the oligomerization of A{beta}42 protein in Alzheimer's disease  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer A{beta} oligomers are neurotoxins and likely the causing agents for Alzheimer's disease. Black-Right-Pointing-Pointer A{beta}42 fusion protein form globular oligomers. Black-Right-Pointing-Pointer A{beta}42 fusion protein oligomers contain SDS-resistant tetramers and hexamers. Black-Right-Pointing-Pointer Cysteine substitutions at residues 31, 32, 34, 39-41 disrupt A{beta}42 oligomerization. -- Abstract: Deposition of amyloid fibrils consisting of amyloid {beta} (A{beta}) protein as senile plaques in the brain is a pathological hallmark of Alzheimer's disease. However, a growing body of evidence shows that soluble A{beta} oligomers correlate better with dementia than fibrils, suggesting that A{beta} oligomers may be the primary toxic species. The structure and oligomerization mechanism of these A{beta} oligomers are crucial for developing effective therapeutics. Here we investigated the oligomerization of A{beta}42 in the context of a fusion protein containing GroES and ubiquitin fused to the N-terminus of A{beta} sequence. The presence of fusion protein partners, in combination with a denaturing buffer containing 8 M urea at pH 10, is unfavorable for A{beta}42 aggregation, thus allowing only the most stable structures to be observed. Transmission electron microscopy showed that A{beta}42 fusion protein formed globular oligomers, which bound weakly to thioflavin T and Congo red. SDS-PAGE shows that A{beta}42 fusion protein formed SDS-resistant hexamers and tetramers. In contrast, A{beta}40 fusion protein remained as monomers on SDS gel, suggesting that the oligomerization of A{beta}42 fusion protein is not due to the fusion protein partners. Cysteine scanning mutagenesis at 22 residue positions further revealed that single cysteine substitutions of the C-terminal hydrophobic residues (I31, I32, L34, V39, V40, and I41) led to disruption of hexamer and tetramer formation, suggesting that hydrophobic interactions between these residues are most critical for A{beta}42 oligomerization.

Ngo, Sam [Department of Neurology, Brain Research Institute, Molecular Biology Institute, University of California, Los Angeles, CA 90095 (United States)] [Department of Neurology, Brain Research Institute, Molecular Biology Institute, University of California, Los Angeles, CA 90095 (United States); Guo, Zhefeng, E-mail: zhefeng@ucla.edu [Department of Neurology, Brain Research Institute, Molecular Biology Institute, University of California, Los Angeles, CA 90095 (United States)] [Department of Neurology, Brain Research Institute, Molecular Biology Institute, University of California, Los Angeles, CA 90095 (United States)

2011-10-28T23:59:59.000Z

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

DEVELOPMENT OF AUTOMATED SOFTWARE PROGRAM FOR THE ANALYSIS OF ALZHEIMER'S DISEASE BETA-AMYLOID SCANS  

SciTech Connect (OSTI)

Study goal: A Phase 1 evaluation of the kinetics, clearance and cerebral distribution of one novel peripheral benzodiazepine receptors(PBR)positron emission tomography (PET) imaging agent, 18F-PBR-111 following intravenous administration in healthy volunteers and Alzheimer's disease (AD) patients. Short title: Evaluation of PET imaging with PBR-111 in HV and AD subjects Proof of Mechanism. Primary Objective: To evaluate the cerebral distribution of PBR-111 positron emission tomography (PET) for detection/exclusion of microglial activation in patients with Alzheimer's disease subjects compared to healthy volunteers. Secondary objectives: - To assess the dynamic uptake and washout of [18F]PBR-111, a potential imaging bio-marker for inflammatory changes in brain, using positron emission tomography in subjects with Alzheimer's disease (AD) and healthy volunteers (HV). - To perform blood metabolite characterization of [18F]PBR-111 in subjects with AD and HV to determine the nature of metabolites in assessment of [18F]-PBR-111 as a PET brain imaging agent. Name of radioactive drug substance: PBR-111 Dose(s): The applied PBR-111 radioactive dose will be up to 5.0 mCi, diluted in a maximum of 10 ml of saline. The radioligand will be administered as a slow intravenous bolus injection (i.e., 6 sec/ml) into a large vein (e.g., antecubital vein). Route of administration: Intravenous injection Duration of treatment: Single administration of a diagnostic agent Indication: PBR-111 positron emission tomography (PET) imaging has the potential to detect microglial activation. In the presence of PBR-111 uptake (representative of microglial activation), inflammation in the brain can be detected. Diagnosis and main criteria for inclusion: Study participants will be HVs and patients diagnosed with probable AD. HVs must be 18 years of age (at least four subjects 50 years of age) and have no evidence of cognitive impairment or other neurologic disease by medical history. The lack of cognitive impairment will also be based on a Clinical Dementia Rating (CDR) of 0. Patients with probable AD must be 50 years of age and must fulfill the National Institute of Neurological and Communicative Disorders and Stroke, Alzheimer's Disease and Related Disorders Association [NINCDS-ADRDA] criteria for probable AD. The CDR score must be 1.0 and 2.0 and have a modified Hachinski of 4. All HVs and all patients with probable AD must be able to comply with all study procedures. Study design: This is a Phase 1, open-label, single-center, non-randomized single dose study to assess the kinetics, clearance and cerebral distribution of PBR-111 PET imaging in detecting microglial activation in the brain in patients with probable AD compared to HVs. All aspects related to image acquisition, processing, and visual as well as quantitative evaluation will be developed, optimized, and validated (where required). Each subject will be required to visit the study center during the screening phase and on the PBR-111 PET imaging day (baseline). A telephone follow-up visit will be performed 7 days (± 3 days) after PBR-111 PET administration. At the screening visit, each subject (or caregiver in the case of AD subjects) will be asked to provide written informed consent or assent. During the screening phase (maximum duration of 60 days) subject medical, neurological, and surgical history, clinical assessments, and a neuro-psychiatric evaluation will be performed on all eligible subjects. Subjects will be allowed to leave the center after all evaluations have been completed. During this period an MRI of the brain will be performed during the screening period. If an MRI of the brain has been performed within six months of the imaging visit using the methods described in the protocol, and there has been no medically significant events in the interim, the previous MRI may be used. During the PBR-111 PET imaging day, all subjects will receive a single intravenous injection of PBR-111 and scanning will be performed over a 3.5 hour period. Each subject will have a telephone follow-up 7 da

Mariotti, Jack; Zubal, George

2013-12-18T23:59:59.000Z

42

E-Print Network 3.0 - alzheimer disease prevention Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Collection: Physics 26 Alzheimer's Research Trust -Guide to Applicants G89v1MLART-GRANT TRACKER February 2010 Page 1 of 16 Summary: to funding scientific studies to find ways to...

43

Automatic Classification of Alzheimers Disease vs. Frontotemporal Dementia: A Decision Tree Approach  

E-Print Network [OSTI]

Sadeghi1 , Tolga Tasdizen1 , Norman L. Foster2 , Angela Y. Wang2 , Satoshi Minoshima3 , Andrew P Approach with FDG-PET Neda Sadeghi , Tolga Tasdizen , Norman L. Foster , Angela Y. Wang , Satoshi Minoshima , Andrew P. Lieberman § . School of Computing, University of Utah, Center for Alzheimers Care

Utah, University of

44

Label-Free Quantitative LC?MS Proteomics of Alzheimer&rsquo...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Label-Free Quantitative LC?MS Proteomics of Alzheimer’s Disease and Normally Aged Human Brains. Label-Free Quantitative LC?MS Proteomics of Alzheimer’s...

45

iCons, 2011 Alzheimers and Aluminum: Lesson Plan  

E-Print Network [OSTI]

© iCons, 2011 Alzheimers and Aluminum: Lesson Plan Handouts to explore mechanistic link between Alzheimer's and aluminum 5. Brief proposal expanding Points to Aluminum's Link With Alzheimer's Disease" from 1989. Provide handout

Auerbach, Scott M.

46

The hallmark of Alzheimer's disease is the deposition of plaques composed of amyloid fibrils of the 40-or 42-residue -amyloid  

E-Print Network [OSTI]

The hallmark of Alzheimer's disease is the deposition of plaques composed of amyloid fibrils of the 40- or 42-residue -amyloid peptide (A(1-40) and A(1-42), respectively) in the brain. Recently, solid-42) oligomers reveal chemical shifts of labeled residues that are indicative of -strand secondary structure

Weston, Ken

47

Colored figures Franke & Gaser (2012): Longitudinal changes in individual BrainAGE in healthy aging, mild cognitive impairment, and Alzheimer's disease  

E-Print Network [OSTI]

Colored figures Franke & Gaser (2012): Longitudinal changes in individual BrainAGE in healthy aging, mild cognitive impairment, and Alzheimer's disease Figure 1: Depiction of the BrainAGE concept. A: The model of healthy brain aging is trained with the chronological age and preprocessed structural MRI data

Gaser, Christian

48

Regional dynamics of -amyloid deposition in healthy elderly, Mild Cognitive Impairment and Alzheimer's disease: a voxelwise PiB-PET longitudinal study  

E-Print Network [OSTI]

and Alzheimer's disease: a voxelwise PiB-PET longitudinal study Nicolas Villain1,2,3,4 , Gaël Chételat1 CHU de Caen, U1077, Caen, France 5. Dept of Nuclear Medicine and Centre for PET, Austin Health, VIC;2 Corresponding author: Victor Villemagne, Department of Nuclear Medicine and Centre for PET, Austin Health, 145

Paris-Sud XI, Université de

49

/ www.sciencexpress.org / 9 February 2012/ Page 1 / 10.1126/science.1217697 Alzheimer's disease is associated with impaired clearance  

E-Print Network [OSTI]

by apolipoprotein E (ApoE). ApoE expression is transcriptionally induced through the action of the nuclear receptors of Alzheimer's disease resulted in enhanced clearance of soluble A within hours in an apoE- dependent manner factor for sporadic AD is allelic variation in the apolipoprotein E (APOE) gene. Possession of an APOE4

Cavusoglu, Cenk

50

Brain Imaging with Positron Emission Tomography: Quantification and Biomedical Applications in Alzheimer's Disease and Brain Tumors  

E-Print Network [OSTI]

Diseases of the brain can result from errors introduced into its chemical systems by viruses, bacteria, genetic abnormalities, drugs, trauma, environmental

Wardak, Mirwais

2013-01-01T23:59:59.000Z

51

Cyclophilin D Deficiency Rescues Axonal Mitochondrial Transport in Alzheimer’s Neurons  

E-Print Network [OSTI]

of synapses relevant to the pathogenesis of Alzheimer’s disease (AD). However, the mechanisms controlling axonal mitochondrial function and transport alterations in AD remain elusive. Here, we report an unexplored role of cyclophilin D (Cyp...

Guo, Lan; Du, Heng; Yan, Shiqiang; Wu, Xiaoping; Mckhann, Guy M.; Chen, John Xi; Yan, Shirley ShiDu

2013-01-31T23:59:59.000Z

52

Using yeast to study neurodegenerative diseases : amyloid formation as a protective mechanism and a new Alzheimer's disease model  

E-Print Network [OSTI]

Numerous neurodegenerative diseases are pathologically characterized by idiosyncratic protein amyloid inclusions. Not surprisingly amyloid fibrils have long been proposed to be the toxic protein species in these neurodegenerative ...

Treusch, Sebastian

2011-01-01T23:59:59.000Z

53

ada: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and 2.3 (i, Finalize, Swap, and Display. The package BuiltInTypes supplies these operations for Ada's built-in scalar Initialize, Finalize, Swap, Copy, TestIfEqual and...

54

DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT  

E-Print Network [OSTI]

, Farlow MR, Doody RS, et al.: A 24-week double-blind, placebo-controlled trial of donepezil in patients with Alzhe- imer's disease. Neurology 1998, 44:2308-2314. 4. Corey-Bloom J, Anand R, Veach J: A randomized trial evaluating the efficacy and safety... , 58:427-433. 25. Holmes C, Wilkinson D, Dean C, et al.: The efficacy of donepezil in the treatment of neuropsychiatric symptoms in Alzhe- imer disease. Neurology 2004, 63:214-219. 26. Tariot PN, Farlow MR, Grossberg GT, et al.: Memantine Treat- ment...

Jones, Rob; Sheehan, Bart; Phillips, Patrick; Juszczak, Ed; Adams, Jessica; Baldwin, Ashley; Ballard, Clive; Banerjee, Sube; Barber, Bob; Bentham, Peter; Brown, Richard; Burns, Alistair; Dening, Tom; Findlay, David; Gray, Richard; Griffin, Mary; Holmes, Clive; Hughes, Alan; Jacoby, Robin; Johnson, Tony; Jones, Roy; Knapp, Martin; Lindesay, James; McKeith, Ian; McShane, Rupert; Macharouthu, Ajay; O'Brien, John; Onions, Caroline; Passmore, Peter; Raftery, James; Ritchie, Craig; Howard, Rob; Domino-ad Team

2009-07-24T23:59:59.000Z

55

Ada Yonath: Another Pioneering Woman in Science | Department...  

Broader source: Energy.gov (indexed) [DOE]

Pioneering Woman in Science March 25, 2011 - 4:51pm Addthis Nobel Prize winner in Chemistry, Ada Yonath | Credit nobelprize.org Nobel Prize winner in Chemistry, Ada Yonath |...

56

Early Brain Response to Low-Dose Radiation Exposure Involves Molecular Networks and Pathways Associated with Cognitive Functions, Advanced Aging and Alzheimer's Disease  

SciTech Connect (OSTI)

Understanding the cognitive and behavioral consequences of brain exposures to low-dose ionizing radiation has broad relevance for health risks from medical radiation diagnostic procedures, radiotherapy, environmental nuclear contamination, as well as earth orbit and space missions. Analyses of transcriptome profiles of murine brain tissue after whole-body radiation showed that low-dose exposures (10 cGy) induced genes not affected by high dose (2 Gy), and low-dose genes were associated with unique pathways and functions. The low-dose response had two major components: pathways that are consistently seen across tissues, and pathways that were brain tissue specific. Low-dose genes clustered into a saturated network (p < 10{sup -53}) containing mostly down-regulated genes involving ion channels, long-term potentiation and depression, vascular damage, etc. We identified 9 neural signaling pathways that showed a high degree of concordance in their transcriptional response in mouse brain tissue after low-dose radiation, in the aging human brain (unirradiated), and in brain tissue from patients with Alzheimer's disease. Mice exposed to high-dose radiation did not show these effects and associations. Our findings indicate that the molecular response of the mouse brain within a few hours after low-dose irradiation involves the down-regulation of neural pathways associated with cognitive dysfunctions that are also down regulated in normal human aging and Alzheimer's disease.

Lowe, Xiu R; Bhattacharya, Sanchita; Marchetti, Francesco; Wyrobek, Andrew J.

2008-06-06T23:59:59.000Z

57

Inside Alzheimer's Disease  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-SeriesFlickrinformation for and Novel Computational Impact onParticlesPhysics

58

Inside Alzheimer's Disease  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfrared Land Surface Emissivity inFermilabWhich1 Welcome to63 January 2015 27

59

MRI Study on Maple Syrup Urine Disease via the LONI Pipeline With the creation of large image datasets for quantitative disease classification and diagnosis, like the Alzheimer's Disease  

E-Print Network [OSTI]

MRI Study on Maple Syrup Urine Disease via the LONI Pipeline Overview: With the creation of large pipeline implementation. Given this need, software tools like STAMPS (http://www.ncbi.nlm.nih.gov/pubmed/19346025) and the LONI Pipeline (http://pipeline.loni.ucla.edu/) were developed. These tools integrate

Bjørnstad, Ottar Nordal

60

ada compiler system: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

in Gypsy Boyer, Robert Stephen 2 Modularization of the DADAISM Ada Database System Architecture Computer Technologies and Information Sciences Websites Summary: Page 1...

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

ADA ES Inc | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating SolarElectric Coop,SaveWhiskey FlatshydroMultiple GeothermalHawaiiFlowchart JumpADA ES

62

CD147 is a regulatory subunit of the gamma-secretase complex inAlzheimer's disease amyloid beta-peptide production  

SciTech Connect (OSTI)

{gamma}-secretase is a membrane protein complex that cleaves the {beta}-amyloid precursor protein (APP) within the transmembrane region, following prior processing by {beta}-secretase, producing amyloid {beta}-peptides (A{beta}{sub 40} and A{beta}{sub 42}). Errant production of A{beta}-peptides that substantially increases A{beta}{sub 42} production has been associated with the formation of amyloid plaques in Alzheimer's disease patients. Biophysical and genetic studies indicate that presenilin-1 (Psn-1), which contains the proteolytic active site, and three other membrane proteins, nicastrin (Nct), APH-1, and PEN-2 are required to form the core of the active {gamma}-secretase complex. Here, we report the purification of the native {gamma}-secretase complexes from HeLa cell membranes and the identification of an additional {gamma}-secretase complex subunit, CD147, a transmembrane glycoprotein with two immunoglobulin-like domains. The presence of this subunit as an integral part of the complex itself was confirmed through co-immunoprecipitation studies of the purified protein from HeLa cells and solubilized complexes from other cell lines such as neural cell HCN-1A and HEK293. Depletion of CD147 by RNA interference was found to increase the production of A{beta} peptides without changing the expression level of the other {gamma}-secretase components or APP substrates while CD147 overexpression had no statistically significant effect on amyloid {beta}-peptide production, other {gamma}-secretase components or APP substrates, indicating that the presence of the CD147 subunit within the {gamma}-secretase complex directly down-modulates the production of A{beta}-peptides. {gamma}-secretase was first recognized through its role in the production of the A{beta} peptides that are pathogenic in Alzheimer's disease (AD) (1). {gamma}-secretase is a membrane protein complex with unusual aspartyl protease activity that cleaves a variety of type I membrane proteins, such as APP, CD44, DCC, ErbB4, E-cadherin, LRP, N-cadherin, Nectin-1, and Notch, within their transmembranous regions (2-11); therefore, in addition to its role in AD, {gamma}-secretase has been found to participate in other important biological functions, such as intracellular signaling. {gamma}-secretase processing of APP requires prior removal of a major fragment of the APP extracellular domain (sAPP{sub {beta}}) by {beta}-secretase to yield a membrane bound fragment (APP CTF{sub {beta}}). Subsequent cleavage of this membrane bound fragment by {gamma}-secretase results in the release of the Alzheimer's disease (AD) associated amyloid {beta}-peptides (12). The proteolytic activity of {gamma}-secretase is found not to be critically dependent on the specific sequence, but instead on the size of the extracellular domain (13); such sequence independent characteristics of the substrate are reminiscent of those of the 26S proteasome complex that cleaves substrates in a non-sequence specific manner. {gamma}-secretase is present in almost all animal species, vertebrates and invertebrates; it is expressed in many human organs and tissues.

Zhou, Shuxia; Zhou, Hua; Walian, Peter J.; Jap, Bing K.

2005-04-06T23:59:59.000Z

63

adenosin deaminasa ada: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

James A Zwiebel; Eli Gilboa; R Michael Blaese; Arthur Nienhuis; Richard J O& apos; reilly; W. French Anderson 1987-01-01 12 ADA: A Language for Robot Programming? Computer...

64

E-Print Network 3.0 - alzheimer type onset Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Alzheimer's disease (EOAD) and late-onset... ), with the parents and siblings of 131 LOAD patients (diagnosed at or ... Source: Columbia University, Taub Institute, Cognitive...

65

Ohio State ADA Coordinator to Provide Assistance in Indonesia  

E-Print Network [OSTI]

Ohio State ADA Coordinator to Provide Assistance in Indonesia L. Scott Lissner, The Ohio State in Indonesia on disability policy and practice. The trip, from September 15 ­ October 2, 2013, is sponsored, and university professors and students, the U.S. Embassy, along with Helen Keller International Indonesia [a U

Howat, Ian M.

66

ADA Requirements for Workplace Charging Installation | Department of Energy  

Energy Savers [EERE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustionImprovement3 Beryllium-Associated Worker2014DepartmentI325 8ADA Requirements for Workplace

67

City of Ada, Minnesota (Utility Company) | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of Inspector GeneralDepartmentAUDIT REPORTOpenWendeGuoCatalystPathways CalculatorinAcworth, Georgia (UtilityAda

68

E-Print Network 3.0 - act ada accessibility Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of Brest, France... LISyCEA 3883 singhoff@univ-brest.fr Ada-Europe'08 tutorial, Venice - Page 179 ... Source: Brest, Universit de - Dpartement Informatique,...

69

Ada County, Idaho: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating SolarElectric Coop,SaveWhiskeyEnergyAd-Venta Jump to: navigation, search Logo:Ada

70

A restudy of the cylindrical amphoras from the seventh-century Yassi Ada shipwreck  

E-Print Network [OSTI]

, this re-examination of the cylindrical amphoras from the Yassi Ada shipwreck provides evidence for a somewhat similar metrological system in use by the 7th c. This restudy of the Yassi Ada cargo also offers a new interpretation of the shipwreck...

Van Alfen, Peter Gerritt

1995-01-01T23:59:59.000Z

71

E-Print Network 3.0 - ancianos con alzheimer Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

a Shelby C con w named valedictoria... By APRIL TOLER DAILY SUN THE VILLAGES -- H aving lost her mother to Alzheimer's disease and coping... with a sister who has been diagnosed,...

72

Mechanistic insights into mode of action of potent natural antagonists of BACE-1 for checking Alzheimer’s plaque pathology  

SciTech Connect (OSTI)

Highlights: •Accumulation of A? plaques is one of the major pathology associated with Alzheimer’s disease. •Inhibition of ?-Secretase or BACE-1 offers a viable prospect to check the growth of these plaques. •A large virtual dataset of natural compounds was screened against BACE-1. •Top two hits were analyzed for thermodynamic and structural stability using MD simulations. •Their detailed binding mode of actions were elucidated. -- Abstract: Alzheimer’s is a neurodegenerative disorder resulting in memory loss and decline in cognitive abilities. Accumulation of extracellular beta amyloidal plaques is one of the major pathology associated with this disease. ?-Secretase or BACE-1 performs the initial and rate limiting step of amyloidic pathway in which 37–43 amino acid long peptides are generated which aggregate to form plaques. Inhibition of this enzyme offers a viable prospect to check the growth of these plaques. Numerous efforts have been made in recent years for the generation of BACE-1 inhibitors but many of them failed during the preclinical or clinical trials due to drug related or drug induced toxicity. In the present work, we have used computational methods to screen a large dataset of natural compounds to search for small molecules having BACE-1 inhibitory activity with low toxicity to normal cells. Molecular dynamics simulations were performed to analyze molecular interactions between the screened compounds and the active residues of the enzyme. Herein, we report two natural compounds of inhibitory nature active against ?-secretase enzyme of amyloidic pathway and are potent lead molecules against Alzheimer’s disease.

Dhanjal, Jaspreet Kaur [School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067 (India)] [School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067 (India); Goyal, Sukriti [Apaji Institute of Mathematics and Applied Computer Technology, Banasthali University, Tonk 304022, Rajasthan (India)] [Apaji Institute of Mathematics and Applied Computer Technology, Banasthali University, Tonk 304022, Rajasthan (India); Sharma, Sudhanshu [Department of Biotechnology, Delhi Technological University, New Delhi 110042 (India)] [Department of Biotechnology, Delhi Technological University, New Delhi 110042 (India); Hamid, Rabia [Department of Biochemistry, University of Kashmir, Srinagar 190006 (India)] [Department of Biochemistry, University of Kashmir, Srinagar 190006 (India); Grover, Abhinav, E-mail: abhinavgr@gmail.com [School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067 (India)] [School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067 (India)

2014-01-17T23:59:59.000Z

73

ADA/EEO Talking Notes Slide 1-Welcome to the New Employee Orientation session presented by the Office of Equal  

E-Print Network [OSTI]

ADA/EEO Talking Notes Slide 1-Welcome to the New Employee Orientation session presented by the Office of Equal Opportunity & Compliance or EOC. Slide2-This overview will cover EEO, ADA, Retaliation in the workplace. Please direct any of your questions regarding today's overview directly to EOC. Slide 3-The

Weston, Ken

74

David Goodsell PRION ALZHEIMER'S  

E-Print Network [OSTI]

genes HSF activators are an exception - but is that good? (see recent Cell paper on HSF -- problem not just fertility but cancer) unique genes directly relevent to human disease #12;-synuclein: small lipid mining urban pollution drug abuse #12;Mul$ple' Disease'' Genes!" YPK9" Human'disease5related'gene' Gene

Sabatini, David M.

75

How to Run Turing Machines on Encrypted Data Shafi Goldwasser Yael Kalai Raluca Ada Popa  

E-Print Network [OSTI]

How to Run Turing Machines on Encrypted Data Shafi Goldwasser Yael Kalai Raluca Ada Popa Vinod encryption, and garbling schemes work by modeling algorithms as circuits rather than as Turing machines cryptographic schemes for computing Turing machines on encrypted data that avoid the worst-case problem

Sabatini, David M.

76

CryptDB: A Practical Encrypted Relational DBMS Raluca Ada Popa, Nickolai Zeldovich, and Hari Balakrishnan  

E-Print Network [OSTI]

CryptDB: A Practical Encrypted Relational DBMS Raluca Ada Popa, Nickolai Zeldovich, and Hari Balakrishnan {raluca, nickolai, hari}@csail.mit.edu ABSTRACT CryptDB is a DBMS that provides provable. When individual users or enterprises store their sensitive data in a DBMS today, they must trust

Sabatini, David M.

77

Structural imaging biomarkers of Alzheimer's disease: predicting disease progression  

E-Print Network [OSTI]

of Statistics, Biostatistics & Medical Informatics, c Department of Radiology University of Wisconsin - Madison of Pediatric Otorhinolaryngology, 49, 197-206. 10. Vorperian, H. K., Kent, R. D., Lindstrom, M. J., Kalina, C

Boyer, Edmond

78

PROTEIN INTERACTIONS AND DISEASE MARICEL KANN  

E-Print Network [OSTI]

and illnesses, including AIDS, cancer, and Alzheimer's disease. The goal of this session is to discuss interaction data to identify active pathways re- lated to HIV pathogenesis. A functional analysis for successful inference of protein interactions. Chen et al. developed a framework to mine disease

Radivojac, Predrag

79

Functional Genomics of Brain Aging and Alzheimer’s Disease: Focus on Selective Neuronal Vulnerability  

E-Print Network [OSTI]

between two tis- sues (Spearman rank correlation, r, and significance P val- ues), the frontal pole of the Lu et al. study and one of the tissues studied by Khaitovich et al. The investigators de- scribed a highly significant correlation between... the frontal pole in the Lu et al. study and each of the four regions of the cerebral cortex in the Khaitovich et al. study (anterior cingu- late cortex, Broca’s area, prefrontal cortex, and primary vis- ual cortex, r>0.8 and p<0.02), but a lack...

Wang, Xinkun; Michaelis, Mary L.; Michaelis, Elias K.

2010-10-21T23:59:59.000Z

80

Macrophages in Alzheimer’s disease: the blood-borne identity  

E-Print Network [OSTI]

limited capacity to divide (Graeber et al. 1992; Kennedy andImmu- nity 19(1):71–82 Graeber MB, Streit WJ, Buringer D,

Gate, David; Rezai-Zadeh, Kavon; Jodry, Dominique; Rentsendorj, Altan; Town, Terrence

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

S100 Inhibitors: A New Paradigm for Treating Alzheimer’s Disease  

E-Print Network [OSTI]

identified, this mechanistic information can be used toward the development of S100 inhibitors that improve memory loss in patients. The availability of novel pharmacological interventions for AD will significantly reduce the monetary and societal impacts...

Mathai, David 1991-

2011-04-27T23:59:59.000Z

82

Free membership Agriculture Alzheimer Antibiotics  

E-Print Network [OSTI]

Davis News Service, Tel:(530) 752-6101 Source: UC Davis Views: 13 views Report this Article Comments (0 Climate DNA Diabetes Diseases Drugs Earth Science Ecology Energy Engineering Environment Genes Genetics by a team of researchers at the University of California, Davis. The recordings provide new information

Kowalczykowski, Stephen C.

83

What is new and exciting in Alzheimer's disease research?  

E-Print Network [OSTI]

Jonsson1 et al., Nature | Letter 2012 1deCODE genetics, 101 Reykjavik, Iceland #12;#12;Alan Turing) at the National Codes Centre at Bletchley Park In 2012 two 70-year-old papers by Alan Turing on the theory of code

84

Educational attainment and rate of cognitive decline in Alzheimer's disease  

E-Print Network [OSTI]

with older adults (B?ckman, Small, Wahlin, & Larsson, 1999; Fillenbaum, Hughes, Heyman, George, & Blazer, 1988; Folstein, Folstein, & McHugh, 1975; Scherr et al., 1988; Snowdon, Ostwald, Kane, & Keenan, 1989). In a qualitative review of the literature...

Hemmy, Laura Sue

2009-05-15T23:59:59.000Z

85

alzheimer disease pathology: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and temporomandibular joints resulted in astrocyte and microglial activation in the brain, accompanied by upregulation of inflammation-related gene expression. The biological...

86

A State-Wide Research Network for Alzheimer's Disease  

SciTech Connect (OSTI)

The Specific Aim of the proposal was to develop an administrative structure that will facilitate the development of AD research across the state of SC by providing key services such as (but not limited to) seeking funding research opportunities, financial tracking, regulatory management, central recruitment, training for investigators and coordinators, data collection, data storing, and data processing to researchers across the state.

Mintzer, Jacobo E.; Bachman, D. L.; Stuckey, M.; Ebeling, M.; Wagner, M. T.; Evans, W. J.; Hirth, V.; Walker, A.; Joglekar, R.; Faison, W.

2014-03-13T23:59:59.000Z

87

Cognitive Reserve and Alzheimer Disease Yaakov Stern, PhD  

E-Print Network [OSTI]

that individual differences in how tasks are processed provide differential reserve against brain pathology or age-related changes. This may take 2 forms. In neural reserve, preexisting brain networks that are more efficient of reserve against brain damage stems from the repeated observation that there does not seem to be a direct

88

Introduction Alzheimer's disease (AD) has an apparent multifactoral  

E-Print Network [OSTI]

methylation of proteins, phospholipids, neurotransmitters and nucleic acids. In addition, S,9-11). Transgenic mice homozygously-lacking apolipoprotein E (ApoE-/-; 12-14) undergo markedly more severe oxidative damage and cognitive impairment when maintained on a folate-deficient diet than do normal mice (15

Graves, Michael V.

89

MEDIMAGE A Multimedia Database Management System for Alzheimer's Disease Patients  

E-Print Network [OSTI]

to serve as a resource for the pediatric neuroimaging research community [6], (2) Brigham RAD Teaching Case Database Department of Radiology, Brigham and Women's Hospital Harvard Medical School [2], (3) Brain Web

Stanchev, Peter

90

A Graph Theoretic Mathematical Model for Alzheimer's disease  

E-Print Network [OSTI]

by microglia, a cytokine that inhibits the secretion of IL1 and TNA. Dysregulation of lipid metabolism lipids that is dysregulated, though its exact mechanism in the AD process is not well

Baras, John S.

91

Insight into Alzheimer's, cancer, anemia gleaned from ribosome...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Insights from ribosome research Insight into Alzheimer's, cancer, anemia gleaned from ribosome research Groundbreaking study of the human ribosome reveals tiny molecular machine is...

92

Multivariate Protein Signatures of Pre-Clinical Alzheimer's Disease in the Alzheimer's Disease Neuroimaging Initiative (ADNI) Plasma Proteome Dataset  

E-Print Network [OSTI]

these samples. Following dataset pruning, 17 analytes passedwere incorporated back into the dataset for assessment ofADNI) Plasma Proteome Dataset Daniel Johnstone 1,2 ,

Johnstone, Daniel; Milward, Elizabeth A.; Berretta, Regina; Moscato, Pablo

2012-01-01T23:59:59.000Z

93

Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer¿s disease from normal cognitive aging  

E-Print Network [OSTI]

Pullman R, Bressman SS, Flint Beal M: Metabolomic profilingMatson WR, Henchcliffe C, Beal MF, Bogdanov M: MetabolomicK, Matson TD, Newhall KM, Beal MF, Brown RH Jr, Kaddurah-

2013-01-01T23:59:59.000Z

94

Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer¿s disease from normal cognitive aging  

E-Print Network [OSTI]

FDA approval of florbetapir F18 injection. N Engl J Medand the florbetapir F18 PET scan—for the detection of

2013-01-01T23:59:59.000Z

95

Data:Bd967143-17e5-468b-839e-4ada02ae4134 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onb5-dcc1fcffd1f2 NoBcfd1c1f-01b6-4a11-8667-d236d8565086 No revision has been4ada02ae4134 No revision has been approved

96

Data:E43ada81-47c3-4830-a717-6cb806a5e67e | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Pagec-01b596aa1744b55997c1cc No revision has been approved for-1837723ccd6b No revisionE43ada81-47c3-4830-a717-6cb806a5e67e No

97

Twisted Protein Aggregates and Disease: The Stability of Sickle Hemoglobin Fibers M. S. Turner,1,* R.W. Briehl,2  

E-Print Network [OSTI]

in diseases from Alzheimer's to sickle cell disease. In this Letter we argue that the twisted nature be fundamentally responsible for the meta- stability, and hence proliferation of, pathological sickle cell fibers. Sickle cell hemoglobin (HbS) possesses a single muta- tion at the #12;6 site (glu ! val) leading

Turner, Matthew

98

Frontiers in Disease Therapies UCSB's integration of critical aspects of biological engineering (drug delivery, systems biology, biomateri-  

E-Print Network [OSTI]

the many diseases that UCSB has cross-disciplinary efforts in, including cancer, diabetes, PTSD, Alzheimer targeting therapeutics to cancer cells while sparing healthy ones. In cancer and diabetes, another failure diabetic patients using closed-loop devices in clinical trials. For more insight into our approach

Akhmedov, Azer

99

Alzheimer's amyloid-? and the disordered structural ensemble characterized using molecular dynamics and NMR spectroscopy  

E-Print Network [OSTI]

NL et al. (2008) Structure and dynamics of the Abeta(21-30)study of the structure and dynamics of the Alzheimer'sShaw DE (2012) Structure and dynamics of an unfolded protein

Ball, Katherine Aurelia

2013-01-01T23:59:59.000Z

100

From Auditory and Visual to Immersive Neurofeedback: Application to Diagnosis of Alzheimer's Disease  

E-Print Network [OSTI]

Advanced Institute of Science and Technology, South Korea elgendi@ntu.edu.sg, jdauwels@ntu.edu.sg, fvialatte@brain.riken.jp, mconstable@ntu.edu.sg, cia@brain.riken.jp, Abstract. In neurofeedback, brain waves immersive activity is enjoyable, stimulating, and can have a healing effect. As an illustration

Cichocki, Andrzej

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Recommendations for ICT use in Alzheimer's Disease assessment: Monaco CTAD expert meeting  

E-Print Network [OSTI]

and NeuroSciences, Maastricht University Medical Center, Maastricht, the Netherlands 15 Palo Alto Veterans Affairs Health Care System, Palo Alto, CA and Department of Psychiatry and Behavioral Sciences, Stanford systems within the aging population. It is therefore important to develop better instruments for assessing

Paris-Sud XI, Université de

102

APOE associated hemispheric asymmetry of entorhinal cortical thickness in aging and Alzheimer's disease  

E-Print Network [OSTI]

with developmental dyslexia. Brain and Language 39, 289–301.asymmetry reductions in dyslexia patients or gender-

2013-01-01T23:59:59.000Z

103

Sleep and markers of cardiovascular disease risk in elderly Alzheimer's caregivers  

E-Print Network [OSTI]

as previous heart attack, heart failure, angina, heartn (%) Includes heart attack, heart failure, angina, heartas previous heart attack, heart failure, angina, heart

Schwartz, Jennifer

2012-01-01T23:59:59.000Z

104

E-Print Network 3.0 - alzheimers disease centers Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

for both normal elderly... persons and those suffering from ... Source: Kim, Mi-Ok - Department of Statistics, University of Kentucky Collection: Mathematics 3 From the...

105

Multiple Events Lead to Dendritic Spine Loss in Triple Transgenic Alzheimer's Disease Mice  

E-Print Network [OSTI]

Simon M. Ochs 1 , Nadine Hoffmann 1 , Gerda Mitteregger 1 ,M, Burgold S, Ochs SM, Hoffmann N, et al. (2010) Multiple

2010-01-01T23:59:59.000Z

106

Targeting the brain : identifying and inhibiting harmful protein-amyloid interactions in Alzheimer's disease  

E-Print Network [OSTI]

dishes (MatTek Co. , Ashland, MA) and incubated overnight.collagen (MatTek Co. , Ashland, MA) and incubated overnightdishes (MatTek Co. , Ashland, MA) and incubated overnight.

Habib, Lila K.

2011-01-01T23:59:59.000Z

107

Alzheimer's disease skin fibroblasts selectively express a bradykinin signaling pathway mediating  

E-Print Network [OSTI]

, is generated under conditions known as risk factors for AD, including stroke and traumatic head injury. BK B2 increases I/L B2 BK receptors in AD skin fibroblasts In established human fetal lung fibroblast models of protein kinase C (PKC). We now show that skin fibro- blasts of patients with AD developing around age 35

Steinbach, Joe Henry

108

Brain Imaging with Positron Emission Tomography: Quantification and Biomedical Applications in Alzheimer's Disease and Brain Tumors  

E-Print Network [OSTI]

AB, Elson LM. The human brain coloring book. 1st ed. New21. Toga AW, Mazziotta JC. Brain mapping : the systems. SanSR, Phelps ME. Imaging Brain Function with Positron Emission

Wardak, Mirwais

2013-01-01T23:59:59.000Z

109

Improved Classification of Alzheimer's Disease Data via Removal of Nuisance Variability  

E-Print Network [OSTI]

Initiative 1 VTT Technical Research Centre of Finland,Tampere, Finland, 2 Department ofUniversity of Eastern Finland, Kuopio, Finland, 3 Department

Koikkalainen, Juha; Polonen, Harri; Mattila, Jussi; van Gils, Mark; Soininen, Hilkka; Lotjonen, Jyrki

2012-01-01T23:59:59.000Z

110

Journal of Alzheimer's Disease 14 (2008) 235245 235 Three-Dimensional Tomographic Imaging  

E-Print Network [OSTI]

, Cleveland Ohio, USA f College of Sciences, University of Texas at San Antonio, San Antonio, Texas, USA g microscopy (HR-TEM), energy dispersive X-ray (EDX) spectroscopy and electron energy-loss spectroscopy (EELS of these important roles, iron can also be toxic, with certain forms participating in the production of free radicals

Dunin-Borkowski, Rafal E.

2008-01-01T23:59:59.000Z

111

Impaired Adult Neurogenesis in the Dentate Gyrus of a Triple Transgenic Mouse Model of Alzheimer's Disease  

E-Print Network [OSTI]

Masashi Tabuchi 1 , Stuart M. Allan 1 , Elysse M. Knight 1 ,JJ, Jones VC, Tabuchi M, Allan SM, Knight EM, et al. (2008)

2008-01-01T23:59:59.000Z

112

Estrogen regulation of glucose metabolism and mitochondrial function: Therapeutic implications for prevention of Alzheimer's disease  

E-Print Network [OSTI]

in the aging brain would be predicted to prevent conversion of the brain to using alternative sources of fuel Sciences, University of Southern California, School of Pharmacy Pharmaceutical Sciences Center, Los Angeles glycolysis and citric acid cycle-driven oxidative phosphorylation and ATP generation. Data derived from

Brinton, Roberta Diaz

113

Synchronizing an aging brain: can entraining circadian clocks by food slow Alzheimer's disease?  

E-Print Network [OSTI]

in the external environment. When the SCN is unable to entrain to light-dark cycles, such as when the SCN is experimentally ablated or an animal is in con- ditions of constant darkness, daylight no longer acts as a zeitgeber and circadian organization gradually... . The behavioral arrhythmia was not due to a failing central clock. If these findings translate to AD patients, then it would suggest that the SCN would stay entrained to daylight while the peripheral rhythms affecting behavior become out of sync. If circadian...

Kent, Brianne A.

2014-09-01T23:59:59.000Z

114

Brain Imaging with Positron Emission Tomography: Quantification and Biomedical Applications in Alzheimer's Disease and Brain Tumors  

E-Print Network [OSTI]

HC, Ysaguirre T, inventors; Siemens Medical Solutions USA,HC, Ysaguirre T, inventors; Siemens Medical Solutions USA,ECAT EXACT HR+ PET scanner (Siemens/CTI, Inc. ) consists of

Wardak, Mirwais

2013-01-01T23:59:59.000Z

115

E-Print Network 3.0 - alzheimer disease victim Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Fact ... Source: Washington University in St. Louis, Department of Psychology, Cognitive Control and Psychopathology Laboratory Collection: Biology and Medicine 3...

116

E-Print Network 3.0 - alzheimer disease gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

on ... Source: Washington University in St. Louis, Department of Psychology, Cognitive Control and Psychopathology Laboratory Collection: Biology and Medicine 2 SSV 2010...

117

E-Print Network 3.0 - alzheimer disease analise Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Fact ... Source: Washington University in St. Louis, Department of Psychology, Cognitive Control and Psychopathology Laboratory Collection: Biology and Medicine 3...

118

E-Print Network 3.0 - alzheimer disease Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Fact ... Source: Washington University in St. Louis, Department of Psychology, Cognitive Control and Psychopathology Laboratory Collection: Biology and Medicine 3...

119

E-Print Network 3.0 - alzheimer disease current Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

MAPS ... Source: Washington University in St. Louis, Department of Psychology, Cognitive Control and Psychopathology Laboratory Collection: Biology and Medicine 2 From the...

120

E-Print Network 3.0 - alzheimers disease facts Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

... Source: Washington University in St. Louis, Department of Psychology, Cognitive Control and Psychopathology Laboratory Collection: Biology and Medicine 3 From the...

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Journal of Alzheimer's Disease 31 (2012) 120 DOI 10.3233/JAD-2012-120412  

E-Print Network [OSTI]

Structural Brain Atlases: Design, Rationale, and Applications in Normal and Pathological Cohorts Pravat K Brain Research Center, Gurgaon, India bDepartment of Radiology, Johns Hopkins Medicine, Baltimore, MD magnetic resonance imaging (MRI) provides anatomical information about the brain in healthy as well

Mandal, Pravat K.

122

In Vivo Characterization of CLR01, an Aggregation and Toxicity Inhibitor, with an Alzheimer's Disease Focus  

E-Print Network [OSTI]

structural basis of protein folding and its links with human93. Dobson CM (2003) Protein folding and misfolding. NatureCM (2004) Principles of protein folding, misfolding and

Attar, Aida

2013-01-01T23:59:59.000Z

123

Body mass index is associated with biological CSF markers of core brain pathology of Alzheimer's disease  

E-Print Network [OSTI]

Schneider JA, Leurgans S, Bennett DA. Physical frailty inJA, Wilson RS, Bienias JL, Bennett DA. Body mass index inFitzpatrick e , David Bennett f , Lennart Minthun d , John

2011-01-01T23:59:59.000Z

124

Targeting the brain : identifying and inhibiting harmful protein-amyloid interactions in Alzheimer's disease  

E-Print Network [OSTI]

NANOpure DIamond water purification system from Barnstead (NANOpure DIamond water purification system from Barnstead (

Habib, Lila K.

2011-01-01T23:59:59.000Z

125

Brain Imaging with Positron Emission Tomography: Quantification and Biomedical Applications in Alzheimer's Disease and Brain Tumors  

E-Print Network [OSTI]

but may also lead to a loss of information and even uselesscan also lead to a loss in the information content contained

Wardak, Mirwais

2013-01-01T23:59:59.000Z

126

A novel invertebrate chordate model for Alzheimer's disease using the ascidian ciona intestinalis  

E-Print Network [OSTI]

H (2006) Regulation of tyrosinase trafficking and processingthe pigment cell marker tyrosinase (data unpublished) haverole in both regulating tyrosinase activity, a biosynthetic

Virata, Michael J.

2009-01-01T23:59:59.000Z

127

MCI CONFERENCE PAPER HORMONAL TREATMENT, MILD COGNITIVE IMPAIRMENT, AND ALZHEIMER'S DISEASE  

E-Print Network [OSTI]

lost at menopause would prevent many of the manifestations of aging, including osteoporosis on the neurotransmitter systems implicated in cognition. Recent hormonal replacement therapy trials in non- demented post-menopausal to the widespread use of Hormone Replacement Therapy (HT) after the menopause, but following the recent publication

Boyer, Edmond

128

Sleep and markers of cardiovascular disease risk in elderly Alzheimer's caregivers  

E-Print Network [OSTI]

was defined as previous heart attack, heart failure, angina,n (%) Includes heart attack, heart failure, angina, heartwas defined as previous heart attack, heart failure, angina,

Schwartz, Jennifer

2012-01-01T23:59:59.000Z

129

3D structure of Alzheimer's amyloid-{beta}(1-42) fibrils Dbeli, David Schubert, and Roland Riek  

E-Print Network [OSTI]

3D structure of Alzheimer's amyloid-{beta}(1-42) fibrils Döbeli, David Schubert, and Roland Riek.pnas.org/misc/reprints.shtml To order reprints, see: Notes: #12;3D structure of Alzheimer's amyloid- (1­42) fibrils Thorsten Lu¨ hrs fibrils (2, 3). Only one 3D structure of an engineered amyloid fibril has yet been determined (4), owing

Riek, Roland

130

Data:82bc8ea2-8b5c-4fec-a440-32b1c2a7ada9 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office695810186 No revisione0a2d50bdf No revision has9-c45258b300ac Noc1e69d7992 No050573 No revisiona440-32b1c2a7ada9

131

BAYSIDE LOT PERMIT and ADA  

E-Print Network [OSTI]

POTREROAVE ILLINOISST TO 101/280 South via Potrero Ave TO 101 North/ Golden Gate Br Turn right on S. Van Ness BRIDGE subject to long delays TO Bay Bridge 80 East TO Bay Bridge 80 East TO Downtown COURTESY OF MISSION

Derisi, Joseph

132

Pesticides and human chronic diseases: Evidences, mechanisms, and perspectives  

SciTech Connect (OSTI)

Along with the wide use of pesticides in the world, the concerns over their health impacts are rapidly growing. There is a huge body of evidence on the relation between exposure to pesticides and elevated rate of chronic diseases such as different types of cancers, diabetes, neurodegenerative disorders like Parkinson, Alzheimer, and amyotrophic lateral sclerosis (ALS), birth defects, and reproductive disorders. There is also circumstantial evidence on the association of exposure to pesticides with some other chronic diseases like respiratory problems, particularly asthma and chronic obstructive pulmonary disease (COPD), cardiovascular disease such as atherosclerosis and coronary artery disease, chronic nephropathies, autoimmune diseases like systemic lupus erythematous and rheumatoid arthritis, chronic fatigue syndrome, and aging. The common feature of chronic disorders is a disturbance in cellular homeostasis, which can be induced via pesticides' primary action like perturbation of ion channels, enzymes, receptors, etc., or can as well be mediated via pathways other than the main mechanism. In this review, we present the highlighted evidence on the association of pesticide's exposure with the incidence of chronic diseases and introduce genetic damages, epigenetic modifications, endocrine disruption, mitochondrial dysfunction, oxidative stress, endoplasmic reticulum stress and unfolded protein response (UPR), impairment of ubiquitin proteasome system, and defective autophagy as the effective mechanisms of action. - Highlights: ? There is a link between exposure to pesticides and incidence of chronic diseases. ? Genotoxicity and proteotoxicity are two main involved mechanisms. ? Epigenetic knowledge may help diagnose the relationships. ? Efficient policies on safe use of pesticides should be set up.

Mostafalou, Sara; Abdollahi, Mohammad, E-mail: Mohammad.Abdollahi@UToronto.Ca

2013-04-15T23:59:59.000Z

133

Data:Ebe2f59a-da2e-484b-a50b-f7e9b86dc38b | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Pagec-01b596aa1744b55997c1cc No revision hasa3e396ee3ebbed0-6678a6880d18Ebe2f59a-da2e-484b-a50b-f7e9b86dc38b No revision has

134

Sorghum Diseases.  

E-Print Network [OSTI]

of organisms attacking seeds. Environmental conditions 1 encourage seed rot development also W~II increase the amount of damage caused by seedling disease. Vigorous seedlings produc:d from high-quality seed can withstand attack much better than low.... This fungus can cause considerable sorghum damage, although it usually is confined to individual fields or areas within fields that are occasionally flooded. Sorghum downy mildew, Sclerospora sorghi (Kulk) Weston & Uppal, was found first in Texas in 196...

Amador, Jose; Berry, Robert W.; Frederiksen, Richard A.; Horne, C. Wendell; Thames, Walter H.; Toler, Robert W.

1969-01-01T23:59:59.000Z

135

Beryllium disease  

SciTech Connect (OSTI)

After two workers at the nuclear weapons plant at Oak Ridge National Laboratory in Tennessee were diagnosed earlier this year with chronic beryllium disease (CBD), a rare and sometimes fatal scarring of the lungs, the Department of Energy ordered up a 4-year probe. Now, part of that probe has begun - tests conducted by the Oak Ridge Associated Universities' Center for Epidemiological Research measuring beryllium sensitivity in 3,000 people who've been exposed to the metal's dust since Manhattan Project managers opened the Y-12 plant at Oak Ridge in 1943. Currently, 119 Y-12 employees process beryllium, which has a number of industrial uses, including rocket heat shields and nuclear weapon and electrical components. The disease often takes 20 to 25 years to develop, and the stricken employees haven't worked with beryllium for years. There is no cure for CBD, estimated to strike 2% of people exposed to the metal. Anti-inflammatory steroids alleviate such symptoms as a dry cough, weight loss, and fatigue. Like other lung-fibrosis diseases that are linked to lung cancer, some people suspect CBD might cause some lung cancer. While difficult to diagnose, about 900 cases of CBD have been reported since a Beryllium Case Registry was established in 1952. The Department of Energy (DOE) estimates that about 10,000 DOE employees and 800,000 people in private industry have worked with beryllium.

Not Available

1991-12-20T23:59:59.000Z

136

Alzheimer's Disease: NMR Studies of Asialo (GM1) and Trisialo (GT1b) Ganglioside Interactions with A (1-40)  

E-Print Network [OSTI]

component of amyloid deposits is a 39­42 amino acid residue peptide, A (2,3), a product of proteolytic worldwide and is associated with progressive deposits of amyloid plaques (1) in the brain. The prin- cipal). In this report, A refers to the 1­40 amino acid residue peptide unless designated otherwise. A link between

Mandal, Pravat K.

137

Assessment of Alzheimer's disease risk with structural and functional magnetic resonance imaging : an arterial spin labeling study  

E-Print Network [OSTI]

175-182. Wierenga, C.E. , Stricker, N.R. , McCauley, A. ,ofAging, 30, 1276-1287. Stricker, N.H. , Schweinsburg,W. Bondi, Ph.D. , Nikki H. Stricker, Ph.D. , Amy J. Jak,

Bangen, Katherine J.

2010-01-01T23:59:59.000Z

138

Am J Epidemiol . Author manuscript Aluminum and silica in drinking water and the risk of Alzheimers disease'  

E-Print Network [OSTI]

Am J Epidemiol . Author manuscript Page /1 10 Aluminum and silica in drinking water and the risk associations between exposure to aluminum or silica from drinking water and risk of cognitive decline, dementia of dementia, aged' 65 years and over living in 91 civil drinking water areas in Southern France. Two measures

Paris-Sud XI, Université de

139

Hormonal treatment, mild cognitive impairment and Alzheimer's disease Ryan Joanne , Scali Jaqueline , Carriere Isabelle , Ritchie Karen , Ancelin Marie-Laure *  

E-Print Network [OSTI]

lost at menopause would prevent many of the manifestations of aging, including osteoporosis systems implicated in cognition. Recent hormonal replacement therapy trials in non-demented post-menopausal to the widespread use of Hormone Replacement Therapy (HT) after the menopause, but following the recent publication

Boyer, Edmond

140

Label-Free Quantitative LC&minus;MS Proteomics of Alzheimer&rsquo;s Disease  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: VegetationEquipment Surfaces and Interfaces Sample6, 2011 LOSEngineering |LabVideo Lab-Corpsand Normally

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Exploration of the role of gangliosides and cholesterol in the mechanism of ?-amyloid neurotoxicity in Alzheimer's disease  

E-Print Network [OSTI]

to A? toxicity. In this work, we explored the role of gangliosides and cholesterol in the mechanism of A? neurotoxicity in AD. Specifically, we investigated the feasibility that the binding between A? and the cell membrane, which is proposed...

Yoo, Suk Joon

2002-01-01T23:59:59.000Z

142

Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease  

E-Print Network [OSTI]

Pharmacol. Lin, M.T. , Beal, M.F. , 2006. Mitochondrialcharacteristic of AD (Lin and Beal, 2006). AD is a complex

Bondy, Stephen Bondy C

2011-01-01T23:59:59.000Z

143

Interim Chronic Beryllium Disease  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

Establishes Departmental expectations for addressing chronic beryllium disease throughout the Department until a Departmental rule on beryllium is promulgated. This Notice was replaced by final rule 10 CFR Part 850, Chronic Beryllium Disease Prevention Program, published December 8, 1999.

1999-12-08T23:59:59.000Z

144

Reproductive Diseases in Cattle  

E-Print Network [OSTI]

This publication describes prevention measures, symptoms, diagnosis and treatment options for the most common reproductive diseases in cattle: brucellosis (Bang's disease); leptospirosis; infectious bovine rhinotracheitis (IBR) and bovine diarrhea...

Sprott, L. R.; Field, Bob

1998-12-03T23:59:59.000Z

145

Cardiovascular Disease (CVD) Coronary heart disease  

E-Print Network [OSTI]

have a greater prevalence in women · Osteoporosis · Autoimmune disease A. Osteoporosis · Osteoporosis ­ disorder of low bone mass, microarchitectural denegra7on% of all women >65 years old have osteoporosis (15% of all Caucasian women

Dever, Jennifer A.

146

Using Wikipedia to forecast diseases  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Using Wikipedia to forecast diseases Using Wikipedia to forecast diseases Scientists can now monitor and forecast diseases around the globe more effectively by analyzing views of...

147

ADAS WORKSHOP 23-25 September 2012  

E-Print Network [OSTI]

-cation and atom-molecule reactive collisions in the cold regions of the fusion plasmas 20' F. Guzmán New molecular of the Institut de Recherche sur la Fusion Magnétique 08.50­08.55 Adjustments and ratification of the agenda. 1st 20' Discussion 10.30 Coffee #12;2nd session: Atomic physics and fusion plasma diagnostics 10

Strathclyde, University of

148

Ada, Minnesota: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating SolarElectric Coop,SaveWhiskeyEnergyAd-Venta Jump to: navigation, search Logo:Adais a

149

Ada, Oklahoma: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating SolarElectric Coop,SaveWhiskeyEnergyAd-Venta Jump to: navigation, search Logo:Adais

150

Ada, Ohio: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home5b9fcbce19 NoPublic Utilities Address: 160 East 300 SouthWaterBrasil Jump to: navigation,Diagram Jump694969°, -83.8227148°

151

The 2006 Harvard / Paul F. Glenn Symposium on Aging  

E-Print Network [OSTI]

diseases of aging, such as diabetes, cancer, Alzheimer's and heart disease. A recent study1 concluded

Church, George M.

152

Published: December 30, 2010 r 2010 American Chemical Society 301 dx.doi.org/10.1021/cb1001729 |ACS Chem. Biol. 2011, 6, 301307  

E-Print Network [OSTI]

of diseases including Alzheimer's disease, muscular dystrophy, cancer, diabetes, obesity, and asthma,6

Weiss, Gregory A.

153

IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS 1 High Specificity Binding of Lectins to  

E-Print Network [OSTI]

that affect mankind, including cancer, diabetes, heart diseases, infectious diseases, flu, Alzheimer

Dagenais, Mario

154

June 17, 2013 Symposium on Aging  

E-Print Network [OSTI]

to forestall and treat diseases of aging such as diabetes, cancer, Alzheimer's and heart disease. Today

Church, George M.

155

Radiology of thoracic diseases  

SciTech Connect (OSTI)

This book presents the essential clinical and radiologic findings of a wide variety of thoracic diseases. The authors include conventional, CT and MR images of each disease discussed. In addition, they present practical differential diagnostic considerations for most of the radiographic findings or patterns portrayed.

Swensen, S.J.; Pugatch, R.D.

1989-01-01T23:59:59.000Z

156

Adventures in Infectious Diseases  

ScienceCinema (OSTI)

Dr. Susan Fisher-Hoch, Virologist and Epidemiologist, will discuss her research and travels associated with viral hemorrhagic fevers. From the Ebola outbreak in Reston, Virginia to outbreaks of Crimean Congo Hemorrhagic Fever in South Africa, Senegal, and Saudi Arabia, Dr. Fisher-Hoch has studied and tracked the pathophysiology of these viral diseases. These studies have led her from the Center for Disease Control in the United States, to Lyon, France where she was instrumental in designing, constructing, and rendering operational a laboratory capable of containing some of the world's most dangerous diseases.

Fisher-Hoch, Susan [University of Texas School of Public Health

2014-06-25T23:59:59.000Z

157

Chronic Conditions and Disease Prevention  

E-Print Network [OSTI]

, diabetes, heart disease and osteoarthritis. One-on-One Nutrition Counseling Help with weight management and supportive program for those who have chronic diseases such as diabetes, heart disease, stroke, arthritis

158

ELSEVIER Molecular Brain Research 34 (1995) 118-126 Research report  

E-Print Network [OSTI]

effects in vitro (neurite extension and glial proliferation). In Alzheimer's disease and Down's syndrome of Alzheimer's disease (AD) and Down's syndrome (DS), among other neurodegenerative disorders, are marked

Homes, Christopher C.

159

E-Print Network 3.0 - alleviates age-related oxidative Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Collection: Biology and Medicine 4 Journal of Alzheimer's Disease 6 (2004) 2730 27 Apple juice prevents oxidative stress induced Summary: , neuroblastoma, Alzheimer's disease...

160

Periodontal Disease and Heart Health  

E-Print Network [OSTI]

Periodontal Disease and Heart Health Deaf HealthTalks Presenter: Christopher Lehfeldt, DDS Elmwood #12;X-ray showing bone loss rickwilsondmd.typepad.com Thursday, March 15, 12 #12;5. What is heart disease? · The medical name for heart disease is cardiovascular disease (CVD) · An American dies from CVD

Goldman, Steven A.

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Health & Medicine Heart Disease  

E-Print Network [OSTI]

See Also: Health & Medicine Heart Disease· Medical Imaging· Vioxx· Matter & Energy Electronics· Technology· Medical Technology· Reference Artificial heart· Biosensor· Circuit design· Machine· Science and stretchable electronics can map waves of electrical activity in the heart with better resolution and speed

Rogers, John A.

162

Early Brain Response to Low-Dose Radiation Exposure Involves Molecular Networks and Pathways Associated with Cognitive Functions, Advanced Aging and Alzheimer's Disease  

E-Print Network [OSTI]

and Ingenuity Pathway Analysis (IPA 5.0). GO analyses wasdistribution (p ? 0.001). The IPA knowledge base includesgenes were also analyzed in IPA 5.0 for pathway enrichments

Lowe, Xiu R

2009-01-01T23:59:59.000Z

163

Alterations of brain and cerebellar proteomes linked to ABeta and tau pathology in a female triple-transgenic murine model of Alzheimer's disease  

E-Print Network [OSTI]

Ingenuity Pathway Analysis (IPA), we inferred the functionalKnowledge Base search using the IPA application. This tooland canonical pathways. The IPA- generated networks show the

2010-01-01T23:59:59.000Z

164

Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Abeta/amyloid burden in a transgenic mouse model of Alzheimer's disease  

E-Print Network [OSTI]

correlation of Ab with TGFb and SDF-1. Immunized males showlevels of MCP-1, IL-10, SDF-1, and RANTES in PBS-treatedT, Gawaz M: Decreased CXCL12 (SDF-1) plasma levels in early

2010-01-01T23:59:59.000Z

165

Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease  

E-Print Network [OSTI]

University, Canberra, ACT, Australia. Correspondence: Dr M131 Garran Road, Canberra, ACT 0200, Australia. E-mail:

2012-01-01T23:59:59.000Z

166

Inherited risk for common disease  

E-Print Network [OSTI]

Linkage disequilibrium studies have discovered few gene-disease associations for common diseases. The explanation has been offered that complex modes of inheritance govern risk for cancers, cardiovascular and cerebrovascular ...

Banava, Helen

2007-01-01T23:59:59.000Z

167

E-Print Network 3.0 - arch jacob disease Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

for Psy- chopathology in Alzheimer's ... Source: Columbia University, Taub Institute, Cognitive Neuroscience Division Collection: Biology and Medicine 3 Memory and Executive...

168

EA-0896: Final Environmental Assessment  

Broader source: Energy.gov [DOE]

Center for Nuclear Medicine Research in Alzheimer's Disease Health Sciences Center- West Virginia University

169

A Manual of Poultry Diseases.  

E-Print Network [OSTI]

" of ocular leucosis is specific. Hatchery and Breeder Flock Health Management Sanitation is a much used, but poorly defined word. The usual implication is that sanitation is a universally understood practice that may be applied to prevent all diseases... must be based on the nature of specific diseases. The ;kmbiguity surrounding the term "sanitation" can be avoided by using a term "management and sanitation for disease prevention." This phrase then would be defined as all practices, specific...

Bell, R. R.; Flowers, A. I.; Grumbles, L. C.; Meinecke, C. F.; Patterson, C. M.; Wormell, B. C.; Hall, C. F.

1965-01-01T23:59:59.000Z

170

Genomic mosaicism in the human brain  

E-Print Network [OSTI]

Zlokovic BV (2008) The blood-brain barrier in health andmosaicism in the human brain ………………………………………. Chapter Threethe Alzheimer’s disease brain ………………………………. Chapter Five DNA

Westra, Jurjen Willem

2008-01-01T23:59:59.000Z

171

MFR PAPER 1300 Shellfish Diseases  

E-Print Network [OSTI]

promise for the efficient recycling of organic waste materials, such as agricultural wastes, and metazoan parasitic and infectious agents. In addition, predators, toxic agents, and fouling organisms studied. DISEASES OF SHELLFISH A list of organisms that cause com- mon diseases in oysters is shown

172

Lessons from a rare disease  

E-Print Network [OSTI]

Progeria is a genetic aging disease of childhood affecting an estimated one in four to eight million births. Children with progeria experience a range of developmental disorders and aging-like symptoms, including wrinkled ...

Dutchen, Stephanie Lynn

2009-01-01T23:59:59.000Z

173

A Manual of Poultry Diseases.  

E-Print Network [OSTI]

surrounding the term "sanitation" can be avoided by using the expression "management and sanitation for disease preven- , tion." This phrase then would be defined as all practices, specific and nonspecific, that the poultry- man applies to ptevent.... Change litter and thoroughly clean and disinfect the house and equipment between each group of birds. While litter selection and management is a large subject, applying this recommendation as a general practice will prevent many disease and parasite...

Hall, C. F.; Bell, R. R.; Clifford, R. L., Jr.; Glass, S. E.; Grimes, J. E.; Grumbles, L. C.; Keahey, E. E.; Wormell, B. C.

1971-01-01T23:59:59.000Z

174

Diarrheal Disease in Show Swine  

E-Print Network [OSTI]

cause disease in humans. Contaminated water is the main source of Giardia spp. Bacterial Causes Swine dysentery or ?bloody dysentery? from infec- tion with Brachyspira (Serpulina) hyodysenteriae is a major cause of diarrheal disease in show pigs... (the same area as whipworms) and prevents reabsorption of fluids. Affected pigs severe- ly dehydrate and up to 30 percent can die. Most affected pigs will drink but will not eat. Pigs that recover are intermittent shedders of B. hyodysenteriae and are a...

Lawhorn, D. Bruce

2007-02-27T23:59:59.000Z

175

E-Print Network 3.0 - atherothrombotic cardiovascular disease...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

disease, the number one killer of all Americans. Cardiovascular disease, or heart disease is the primary cause Summary: Kidney disease is both a cause and a consequence...

176

Heart Disease and Early Heart Attack Care  

E-Print Network [OSTI]

Heart Disease and Early Heart Attack Care Pamela Kostic, RN, CCCC, Chest Pain Coordinator, Stony Risk Factors · EHAC & Prevention #12;Heart disease includes a number of problems affecting the heart and the blood vessels in the heart. #12;Types of heart disease include: · Coronary artery disease (CAD) · Angina

Ohta, Shigemi

177

Radiologic atlas of rheumatic diseases  

SciTech Connect (OSTI)

This book is an ''atlas of rheumatic joint disease'' selected from 20 years of personal experience by the author. The author sets a goal of demonstrating the value of soft-tissue imaging in the diagnosis of early joint disease. This goal is achieved with high quality reproductions, many of which are presented in duplicate to illustrate bone and soft-tissue changes. The contents include an introductory overview of the ''Mosaic of Arthritis'' followed by sections on adult rheumatoid arthritis, seronegative spondyloarthropathies, classic collagen disease, enthesiopathies, and lastly a section on gout and psuedogout. The subject index is specific and indexes figures with boldface type. Each section is introduced by a brief outline or overview of the radiographic spectrum of the joint disorder to be illustrated.

Dihlmann, W.

1986-01-01T23:59:59.000Z

178

MONITORING AN ADA SOFTWARE DEVELOPMEN T Victor R. Basili  

E-Print Network [OSTI]

and Elizabeth Kruesi are now with Software Metrics, Inc. Sylvia Sheppard is with Booz, Allen, and Hamilton, Inc

Basili, Victor R.

179

ada releases updated: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Buffalo Foundation. 1983 Research Assistant to Expedition. PROFESSIONAL SOCIETIES and REVIEW BOARDS Professional Societal Affiliations (member) American Association Hood, Craig...

180

adenosine deaminase ada: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

James A Zwiebel; Eli Gilboa; R Michael Blaese; Arthur Nienhuis; Richard J O& apos; reilly; W. French Anderson 1987-01-01 7 A Role for Adenosine Deaminase in Drosophila Larval...

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

COMPETITIVE ADVERTISING WITHIN STORE FLYERS: A WINWIN Ada MIMOUNI CHAABANE*  

E-Print Network [OSTI]

, promote new products and stores, and communicate about price specials (Miranda and Konya, 2006; Pieters et (Burton et al., 1999; Volle, 2001; Gijsbrechts et al., 2003; Miranda and Konya, 2007), increase purchases

Paris-Sud XI, Université de

182

Modularization of the DADAISM Ada Database System Architecture  

E-Print Network [OSTI]

the modularization of a new data- base management system architecture. This DBMS is not intended to be viewed 22, 1986 at Beijing, China. of modulespeci cations for a DBMS, which can be used to support any implemen- tation paradigm is necessary to handle the evolution of database systems over the next few

Keller, Arthur M.

183

Modularization of the DADAISM Ada Database System Architecture  

E-Print Network [OSTI]

the modularization of a new data­ base management system architecture. This DBMS is not intended to be viewed--22, 1986 at Beijing, China. of module specifications for a DBMS, which can be used to support any of those implemen­ tation paradigm is necessary to handle the evolution of database systems over the next few

Keller, Arthur M.

184

Venkatraman Ramakrishnan, Thomas A. Steitz, Ada E. Yonath, and Ribosome  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLasDelivered energy consumption by sectorlongUpdatesValley wins 2015Mayo 2010 la

185

with Disabilities Act Requirements Workplace ADA Requirements for Workplace  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion |Energy UsageAUDIT REPORT Americium/Curium Vitrification Project At TheComplying with

186

Environmental Contributions to Allergic Disease  

E-Print Network [OSTI]

with increased exposure to air pollution and indoor contaminants such as house dust mites, cockroaches linked to the severity of allergic disease. The contribution of house dust mites, cockroaches, animal some of the strongest evidence sug- gests a compelling link between exposure to passive smoking

Levetin, Estelle

187

MENINGOCOCCAL DISEASE WHAT YOU NEED TO KNOW  

E-Print Network [OSTI]

, coughing and having close social contact (living in the same household) are examples of how this disease

Missouri-Rolla, University of

188

Heart Valve Disease James S. Gammie, MD  

E-Print Network [OSTI]

Heart Valve Disease James S. Gammie, MD Professor and Chief Division of Cardiac Surgery University USA Source: CDC #12;#12;CARDIOTHORACIC SURGEON: A SURGEON THAT TREATS HEART AND LUNG DISEASE #12;Valvular Heart Disease: Common and Under-diagnosed 0 2 4 6 8 10 12 14 18 - 44 45 - 54 55 - 64 65 - 74 > 75

Weber, David J.

189

Coronary Heart Disease, Hypertension, Stroke, and  

E-Print Network [OSTI]

Coronary Heart Disease, Hypertension, Stroke, and Diabetes #12;Coronary Heart Disease: Overview by atherosclerosis ­ Narrowing of coronary arteries, the vessels that supply the heart · Disease process: coronary and arms Myocardial infarction - heart attack, ischemia - local blood supply decreased resulting in cell

Meagher, Mary

190

Controlling Diseases on Ornamental Plants.  

E-Print Network [OSTI]

powder is used as a spray to control powdery mildew and foliage diseases. It is available as Daconil 2787?, Bravo? and Ferti-Iome Broad Spectrum Liquid Fungicide?. Formaldehyde: This is a 37 percent solution in water and methanol which is used... and move it over the loosened soil. Drain tile or iron pipe buried in the soil helps to distribute the ste~m. Heat the soil until a medium-sized potato buried several inches deep is cooked thoroughly. Use formaldehyde as manufacturer directs. Water...

Horne, C. Wendell; Johnson, Jerral D.; Walla, Walter J.

1979-01-01T23:59:59.000Z

191

Insight into the principles of amphipathic peptide self-assembly.  

E-Print Network [OSTI]

??Amyloid is associated with protein pathologies such as Alzheimer's disease, Parkinson's Disease, Spongiform Encephalopthies (Mad Cow's Disease), as well as Type II Diabetes. In recent… (more)

Bowerman, Charles James (1985 - ); Nilsson, Bradley L.; Ryan, Derek M. (1985 - ); Nissan, David A.; Liyanage, Wathsala N.

2012-01-01T23:59:59.000Z

192

Clioquinol promotes the degradation of metal-dependent amyloid-?  (A?) oligomers to restore endocytosis and ameliorate A?  toxicity  

E-Print Network [OSTI]

Alzheimer’s disease (AD) is a common, progressive neurodegenerative disorder without effective disease-modifying therapies. The accumulation of amyloid-? peptide (A?) is associated with AD. However, identifying new compounds ...

Lindquist, Susan

193

Therapeutic target for protozoal diseases  

DOE Patents [OSTI]

A novel Fasciclin Related Adhesive Protein (FRAP) from Plasmodium and related parasites is provided as a target for therapeutic intervention in diseases caused by the parasites. FRAP has been shown to play a critical role in adhesion to, or invasion into, host cells by the parasite. Furthermore, FRAP catalyzes the neutralization of heme by the parasite, by promoting its polymerization into hemozoin. This invention provides methods and compositions for therapies based on the administration of protein, DNA or cell-based vaccines and/or antibodies based on FRAP, or antigenic epitopes of FRAP, either alone or in combination with other parasite antigens. Methods for the development of compounds that inhibit the catalytic activity of FRAP, and diagnostic and laboratory methods utilizing FRAP are also provided.

Rathore, Dharmendar (Blacksburg, VA); Jani, Dewal (Blacksburg, VA); Nagarkatti, Rana (Blacksburg, VA)

2008-10-21T23:59:59.000Z

194

Fracture, aging and disease in bone  

E-Print Network [OSTI]

on glucocorticoid-induced osteoporosis. Rheumatic DiseaseGlucocorticoid-induced osteoporosis. Endocrinol Metab. Clin.of cortico-steroid osteoporosis. A meta-analysis. Osteoporos

Ager, J.W.; Balooch, G.; Ritchie, R.O.

2006-01-01T23:59:59.000Z

195

"Artificial" brains, electrical grids, and disease modeling:...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Science discoveries unveiled "Artificial" brains, electrical grids, and disease modeling: Los Alamos science discoveries unveiled September 15 The event is an opportunity for...

196

Functional cardiovascular assessment in congenital heart disease.  

E-Print Network [OSTI]

??abstractAdequate and serial functional cardiovascular assessment is important in patients with congenital heart disease because many show disruption of normal myocardial geometry, which may or… (more)

W.J.B.W. van den Berg

2007-01-01T23:59:59.000Z

197

Enzyme replacement therapy for Pompe disease  

E-Print Network [OSTI]

CALIFORNIA, SAN DIEGO Enzyme Replacement Therapy for Pompe3 1.3 Enzyme Replacement Therapy for Pompe Disease…………………… 5Receptor ERT – Enzyme Replacement Therapy LSD – Lysosomal

Burris, Ryan Jonathan William

2010-01-01T23:59:59.000Z

198

The 2008 Harvard / Paul F. Glenn Symposium on Aging  

E-Print Network [OSTI]

of aging such as diabetes, cancer, Alzheimer's and heart disease. Thus, a major goal in the coming years

Church, George M.

199

The 2009 Harvard / Paul F. Glenn Symposium on Aging  

E-Print Network [OSTI]

of aging such as diabetes, cancer, Alzheimer's and heart disease. Thus, a major goal in the coming years

Church, George M.

200

The definitive version is available at www.blackwell-synergy.com Analysis of the effect of aluminum in drinking water  

E-Print Network [OSTI]

of aluminum in drinking water and transferrin C2 allele on Alzheimer's disease. a Virginie Rondeau, b Albert.Rondeau@isped.u-bordeaux2.fr Key words: aluminum, drinking water, transferrin, apolipoprotein E, Alzheimer's disease Word of a link between aluminum in drinking water and Alzheimer's disease (AD) has been supported by several

Paris-Sud XI, Université de

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Are You at Risk for Heart Disease?  

E-Print Network [OSTI]

vessels going to the heart get narrow and clogged. A heart attack can happen when these blood vesselsAre You at Risk for Heart Disease? Healthy Heart, Healthy Family Nangangamba Ka Bang Magkaroon ng Are You at Risk for Heart Disease? Healthy Heart, Healthy Family Nangangamba Ka Bang Magkaroon ng Sakit sa

Bandettini, Peter A.

202

Coronary Heart Disease, Hypertension, Stroke, and  

E-Print Network [OSTI]

Coronary Heart Disease, Hypertension, Stroke, and Diabetes #12;Coronary Heart Disease: Overview to illnesses caused by atherosclerosis ­ Narrowing of coronary arteries, the vessels that supply the heart that radiates across the chest and arms � Myocardial infarction - heart attack, ischemia - local blood supply

Meagher, Mary

203

HANFORD THYROID DISEASE STUDY FINAL REPORT  

E-Print Network [OSTI]

HANFORD THYROID DISEASE STUDY FINAL REPORT Study Management Team Scott Davis, Ph.D., Principal;Acknowledgments Many individuals have contributed to the success of the Hanford Thyroid Disease Study. We wish: Dr. Floyd Frost and Mr. Eugene Sobota; 3) history of Hanford: Dr. Michelle Stenejhem; 4) statistical

204

X-ray atlas of rheumatic diseases  

SciTech Connect (OSTI)

This atlas comprises instructive X-rays of the various inflammatory rheumatic joint diseases in all stages at the extremities and the spinal column. In addition, the complex pattern of the wide range of arthroses, also known as degenerative rheumatic disease is included. Besides the instructive pointers to X-ray diagnosis, the book is also a guide to differential diagnosis. Hence, this book is actually an X-ray atlas of joint diseases in general. Selected Contents: Introduction: What Does ''Rheumatism'' Actually Mean./Radiographic Methodology in Rheumatic Diseases of the Locomotor System/The Mosaic of Arthritis/Adult Rheumatoid Arthritis/Seronegative Spondylarthritis/Classic Collagen Diseases/Enthesiopathies/Gout-Pseudogout

Dihlmann, W.

1986-01-01T23:59:59.000Z

205

Synthesis and applications of side chain-functionalized polylactic acid-based polymers and studies toward a chemical method to degrade Alzheimer's disease-related beta-amyloid peptides  

E-Print Network [OSTI]

1999, 32 (23), 7711-7718. Ugi, I. ; Fetzer, U. ; Eholzer,isocyanides for the ugi reaction and its application to the2.2 The Ugi and Passerini reactions in organic

Rubinshtein, Mark

2011-01-01T23:59:59.000Z

206

Synthesis and applications of side chain-functionalized polylactic acid-based polymers and studies toward a chemical method to degrade Alzheimer's disease-related beta-amyloid peptides  

E-Print Network [OSTI]

TM (Barnstead) water purification system before use. All NMRTM (Barnstead) water purification system before use. 1-(Diamond TM (Barnstead) water purification system before use.

Rubinshtein, Mark

2011-01-01T23:59:59.000Z

207

Synthesis and applications of side chain-functionalized polylactic acid-based polymers and studies toward a chemical method to degrade Alzheimer's disease-related beta-amyloid peptides  

E-Print Network [OSTI]

Pignatello, R. ; Puglisi, G. , PLA/PLGA nanoparticles forV. ; Ferreira, M. L. , PLA nano- and microparticles for druginto PLA..

Rubinshtein, Mark

2011-01-01T23:59:59.000Z

208

Behavioral impulsivity and hallucinations : insights from Parkinson's disease  

E-Print Network [OSTI]

Parkinson's disease (PD) is an age-related degenerative disease of the brain, characterized by motor, cognitive, and psychiatric symptoms. Neurologists and neuroscientists now understand that several symptoms of the disease, ...

Ashourian, Paymon

2011-01-01T23:59:59.000Z

209

HLB in Argentina: a New Disease Outbreak  

E-Print Network [OSTI]

Vol. 1 (2014) HLB in Argentina: a New Disease Outbreak Outi,E. 6 SENASA, Bs. As. Argentina MAGyP Bs. As INTA Montecarlo,Paraná, 300 km away from Argentina’s Northeastern border. In

2014-01-01T23:59:59.000Z

210

INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH, BANGLADESH  

E-Print Network [OSTI]

©INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH, BANGLADESH J HEALTH POPUL NUTR 2009 00 managers can target resources to identify if such clusters exist. If so, they can then ensure supervi

Scharfstein, Daniel

211

What You Should Know About Plant Diseases.  

E-Print Network [OSTI]

when applied before the attack, thus serving as a preventive measure. With many crops, the occurrence of these attacks is predictable on the basis of past experience. Dusting Plants One may use dusts when controlling diseases with chemicals..., but they are not as effective as spraying. Usually, dusts shoultl be used to supple- ment sprays. Dust preparations are ready-mixed in the proper concentration, ready for application. Crop Rotation and Sanitation During the winter many plant disease organisms may live...

Horne, C. Wendell; Smith, Harlan E.

1962-01-01T23:59:59.000Z

212

Major Oak Diseases and Their Control.  

E-Print Network [OSTI]

)OC ?A245 Q7 173 . \\00 ILl78 , LIBRARY -?'?AUG 3 1?1S84 r ex.J$ MM University MAJOR OAK DISEASES AND THEIR CONTROL 8-1478 J ~ Texas Agricultural Extension Service. The Texas A&M University System ? Zerle L. Carpenter, Director. College... Station, Texas (Blaok Page bl-?OriglulBidletial? / . , ,;..,' ,- ; ~ ~ " OAK DISEASES AND THEIR CONTROL Jerral D. Johnson and David N. Appel* Oaks represent the major shade trees of Texas and are also...

Johnson, Jerral D.; Appel, David N.

1984-01-01T23:59:59.000Z

213

Integrated Molecular Signature of Disease: Analysis of Influenza...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of Disease: Analysis of Influenza Virus-Infected Macaques through Functional Genomics and Integrated Molecular Signature of Disease: Analysis of Influenza Virus-Infected...

214

The Seattle Structure Genomics Center for Infectious Disease...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

The Seattle Structure Genomics Center for Infectious Disease (SSGCID). The Seattle Structure Genomics Center for Infectious Disease (SSGCID). Abstract: The NIAID-funded Seattle...

215

Structural genomics of infectious disease drug targets: the SSGCID...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of infectious disease drug targets: the SSGCID. Structural genomics of infectious disease drug targets: the SSGCID. Abstract: The NIAID-funded SSGCID is a consortium established to...

216

Commercial Pecans: Controlling Rosette, Diseases and Zinc Deficiency  

E-Print Network [OSTI]

Pecan losses from diseases and insufficient zinc nutrition can be prevented by following effective grove management practices. Descriptions of diseases and recommendations for controls are included....

Lee, Thomas A.; Krausz, Joseph P.

2006-04-13T23:59:59.000Z

217

anthracnose disease caused: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

disease of papaya Babak Madani a,*, Mahmud Tengku Muda Mohamed a,**, Alan R. Biggs c , Jugah Kadir October 2013 Keywords: Papaya Anthracnose Calcium Disease incidence...

218

adult celiac disease: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Websites Summary: with a dietitian or physician who specializes in celiac disease. People with celiac disease should always read food for Celiac Awareness; Cynthia Kupper,...

219

ASSISTANT/ASSOCIATE/FULL PROFESSOR Diabetes, Obesity, Metabolic Disease  

E-Print Network [OSTI]

ASSISTANT/ASSOCIATE/FULL PROFESSOR Diabetes, Obesity, Metabolic Disease Department strengths in diabetes, obesity and metabolic disease. Outstanding candidates with expertise

Cinabro, David

220

A Systems Biology Approach to Infectious Disease Research: Innovating...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm. A Systems Biology Approach to Infectious Disease Research: Innovating the...

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Restoration of Endangered White Abalone, Haliotis sorenseni: Resource Assessment, Genetics, Disease and Culture of Captive Abalone  

E-Print Network [OSTI]

Haliotis sorenseni: Resource Assessment, Genetics, Disease,Haliotis sorenseni: Resource Assessment, Genetics, Disease,Haliotis sorenseni: Resource Assessment, Genetics, Disease,

Burton, Ronald S.; McCormick, Thomas B.; Moore, James D.; Friedman, Carolyn S.

2008-01-01T23:59:59.000Z

222

E-Print Network 3.0 - adults cardiovascular disease Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

disease, the number one killer of all Americans. Cardiovascular disease, or heart disease is the primary cause Summary: Kidney disease is both a cause and a consequence...

223

E-Print Network 3.0 - affect cardiovascular disease Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

disease, the number one killer of all Americans. Cardiovascular disease, or heart disease is the primary cause Summary: Kidney disease is both a cause and a consequence...

224

E-Print Network 3.0 - addressing cardiovascular disease Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

disease, the number one killer of all Americans. Cardiovascular disease, or heart disease is the primary cause Summary: Kidney disease is both a cause and a consequence...

225

Chronic beryllium disease: Diagnosis and management  

SciTech Connect (OSTI)

Chronic beryllium disease is predominantly a pulmonary granulomatosis that was originally described in 1946. Symptoms usually include dyspnea and cough. Fever, anorexia, and weight loss are common. Skin lesions are the most common extrathoracic manifestation. Granulomatous hepatitis, hypercalcemia, and kidney stones can also occur. Radiographic and physiologic abnormalities are similar to those in sarcoidosis. While traditionally the pathologic changes included granulomas and cellular interstitial changes, the hallmark of the disease today is the well-formed granuloma. Immunologic studies have demonstrated a cell-mediated response to beryllium that is due to an accumulation of CD4{sup +} T cells at the site of disease activity. Diagnosis depends on the demonstration of pathologic changes (i.e., granuloma) and evidence that the granuloma was caused by a hypersensitivity to beryllium (i.e., positive lung proliferative response to beryllium). Using these criteria, the diagnosis of chronic beryllium disease can now be made before the onset of clinical symptoms. Whether, with early diagnosis, the natural course of this condition will be the same as when it was traditionally diagnosed is not known. Currently, corticosteroids are used to treat patients with significant symptoms or evidence of progressive disease. 21 refs.

Rossman, M.D. [Hospital of the Univ. of Pennsylvania, Philadelphia, PA (United States)

1996-10-01T23:59:59.000Z

226

E-Print Network 3.0 - apoe ko male Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of Disease Common Alzheimer's Disease Risk Variant within the CLU Summary: ; Stricker et al., 2009). Additionally, the apolipoprotein E allele 4 (APOE4)--a widely...

227

acid biomarker detection: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Websites Summary: .g., cancer, Alzheimer's disease) by positron emission tomography (PET).3 In a similar vein, we have developedDisease Detection by Ultrasensitive...

228

Tracking Living Cells as They Differentiate in Real Time  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

these projects will target Alzheimer's disease, macular degeneration of the retina in diabetes, and mitochondrial diseases in children. In addition, specific processes like protein...

229

HORTICULTURAL & FOREST CROPS 2014 Nursery Crops: Diseases 4-1  

E-Print Network [OSTI]

chemicals available. Only chemicals registered by the Environmental Protection Agency (EPA) are recommended.1 - Common Diseases and Chemical Control Options Plant Disease Fungicide Rate/100 Gal Remarks Ajuga;HORTICULTURAL & FOREST CROPS 2014 4-2 Nursery Crops: Diseases Table 4.1 - Common Diseases and Chemical Control

Liskiewicz, Maciej

230

Vascular pathology in the aged human brain  

E-Print Network [OSTI]

vascular pathology, and the AD brain. Neurology 65: 259–265brospinal ?uid from the rat brain. Acta Neuropathol (Berl)and Alzheimer’s disease in the brains of elderly individuals

Grinberg, Lea Tenenholz; Thal, Dietmar Rudolf

2010-01-01T23:59:59.000Z

231

Despite its role in assembly, methionine 35 is not necessary for amyloid ?-protein toxicity  

E-Print Network [OSTI]

An important component of the pathologic process underlying Alzheimer’s disease is oxidative stress. Met[superscript 35] in amyloid ?-protein (A?) is prone to participating in redox reactions promoting oxidative stress, ...

Maiti, Panchanan

232

Mouse and human embryonic stem cells: can they improve human health by preventing disease?  

E-Print Network [OSTI]

diseases, they also have equally great potential to prevent disease by identifying dangerous environmental chemicals

Talbot, Prue

2013-01-01T23:59:59.000Z

233

Purdue Extension Muskmelon and Watermelon Diseases  

E-Print Network [OSTI]

to muskmelons than watermelons. The disease is caused by a fungus (Alternaria cucumerina) that can rapidly Conditions · A brief introduction to the Melcast concept. III. Using Melcast · Acquiring Environmental Data - A description of data requirements for running Melcast. · Translating Environmental Data into EFI Values

234

Vaccine approaches with Edinburgh Infectious Diseases  

E-Print Network [OSTI]

Vaccine approaches with Edinburgh Infectious Diseases Alexander Corbishley #12;The technology approaches to knowledge exchange · October 2013: three technology scouts seconded for 12 months, to identify Congress 2014 (Washington DC) · Local partnering meetings with SMEs · Discussions with Open Innovation

Maizels, Rick

235

Osteoporosis Osteoporosis is a disease character-  

E-Print Network [OSTI]

SS-167-R05 Osteoporosis Osteoporosis is a disease character- ized by structural deterioration of bone tissue, leading to fragile bones and low bone mass. Osteoporosis can weaken bones and cause them" because bone loss occurs with- out symptoms. Many people may not know that they have osteoporosis until

236

DISEASES OF AQUATIC ORGANISMS Dis Aquat Org  

E-Print Network [OSTI]

), and hybrid striped bass (Evans et al. 2000). Clinical symptoms of S. iniae infection in fish include loss from the freshwater dolphin Inia geoffrensis (Pier & Madin 1976), S. iniae infects a wide range of fish infection in humans who have handled diseased fish (Weinstein et al. 1997). Despite the need for novel

Nizet, Victor

237

Northern Kentucky University Communicable Disease Protocol  

E-Print Network [OSTI]

Northern Kentucky University Communicable Disease Protocol Approved 12/6/2011 1.0 Scope To develop procedures and policies for Northern Kentucky University students who reside on or off- campus who have been those required as outlined in 902 KAR 2:020 to be reported to the Northern Kentucky Health Department

Boyce, Richard L.

238

Disease Prediction Models and Operational Readiness  

SciTech Connect (OSTI)

INTRODUCTION: The objective of this manuscript is to present a systematic review of biosurveillance models that operate on select agents and can forecast the occurrence of a disease event. One of the primary goals of this research was to characterize the viability of biosurveillance models to provide operationally relevant information for decision makers to identify areas for future research. Two critical characteristics differentiate this work from other infectious disease modeling reviews. First, we reviewed models that attempted to predict the disease event, not merely its transmission dynamics. Second, we considered models involving pathogens of concern as determined by the US National Select Agent Registry (as of June 2011). Methods: We searched dozens of commercial and government databases and harvested Google search results for eligible models utilizing terms and phrases provided by public health analysts relating to biosurveillance, remote sensing, risk assessments, spatial epidemiology, and ecological niche-modeling, The publication date of search results returned are bound by the dates of coverage of each database and the date in which the search was performed, however all searching was completed by December 31, 2010. This returned 13,767 webpages and 12,152 citations. After de-duplication and removal of extraneous material, a core collection of 6,503 items was established and these publications along with their abstracts are presented in a semantic wiki at http://BioCat.pnnl.gov. Next, PNNL’s IN-SPIRE visual analytics software was used to cross-correlate these publications with the definition for a biosurveillance model resulting in the selection of 54 documents that matched the criteria resulting Ten of these documents, However, dealt purely with disease spread models, inactivation of bacteria, or the modeling of human immune system responses to pathogens rather than predicting disease events. As a result, we systematically reviewed 44 papers and the results are presented in this analysis.

Corley, Courtney D.; Pullum, Laura L.; Hartley, David M.; Benedum, Corey M.; Noonan, Christine F.; Rabinowitz, Peter M.; Lancaster, Mary J.

2014-03-19T23:59:59.000Z

239

Free membership Agriculture Alzheimer Astronomy  

E-Print Network [OSTI]

Ecology Energy Engineering Environment Genetics Geology Global warming HIV Health Heart Immune system Life geophysics Browse Articles Category: All Articles Better Bioremediation at Uranium Mill Tailings Site Published on 16 February 2009, 08:42 Last Update: 11 hour(s) ago by Insciences Tags: Uranium U

Lovley, Derek

240

Poultry Diseases Expert System using Dempster-Shafer Theory  

E-Print Network [OSTI]

Based on World Health Organization (WHO) fact sheet in the 2011, outbreaks of poultry diseases especially Avian Influenza in poultry may raise global public health concerns due to their effect on poultry populations, their potential to cause serious disease in people, and their pandemic potential. In this research, we built a Poultry Diseases Expert System using Dempster-Shafer Theory. In this Poultry Diseases Expert System We describe five symptoms which include depression, combs, wattle, bluish face region, swollen face region, narrowness of eyes, and balance disorders. The result of the research is that Poultry Diseases Expert System has been successfully identifying poultry diseases.

Maseleno, Andino

2012-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Texas Plant Disease Diagnostic Lab Information Form  

E-Print Network [OSTI]

TEXAS PLANT DISEASE DIAGNOSTIC LABORATORY 1500 Research Parkway, Suite A130 Texas A&M University Research Park College Station, Texas 77845 e-mail: plantclinic@ag.tamu.edu phone: 979.845.8032 fax: 979.845.6499 http..., disability, religion, age, or national origin. The Texas A&M System, U.S. Department of Agriculture, and the County Commissioners Courts of Texas cooperating. Please complete form for diagnostic services. Please PRINT and mark ? all that apply. PLANT...

Barnes, Larry W.

2009-01-16T23:59:59.000Z

242

Women and Heart Disease: Neglected Directions for Future Research  

E-Print Network [OSTI]

009-9110-0 Women and Heart Disease: Neglected Directions forage 65, women have less heart disease than men. For many1980s showed a lower risk of heart attacks in postmenopausal

Barrett-Connor, Elizabeth

2009-01-01T23:59:59.000Z

243

alberta kidney disease: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

for nearly 44 percent of new cases.1 Even when diabetes is controlled, the disease can lead to CKD Baker, Chris I. 2 Kidney Dysplasia National Kidney and Urologic Diseases...

244

animal virus diseases: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Physics Websites Summary: Modelling the spread of foot-and-mouth disease virus F Moutou B Durand CNEVA, Laboratoire Central-and-mouth disease is an economically important viral...

245

animal disease models: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Physics Websites Summary: Modelling the spread of foot-and-mouth disease virus F Moutou B Durand CNEVA, Laboratoire Central-and-mouth disease is an economically important viral...

246

Characterization of a Drosophila model of Huntington's disease  

E-Print Network [OSTI]

Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation ...

Lee, Wyan-Ching Mimi

2006-01-01T23:59:59.000Z

247

Annular lichen planus in association with Crohn disease  

E-Print Network [OSTI]

of Crohn disease and a sickle cell trait. Therapy withparasites were excluded. Sickle cell trait was diagnosed (

Serrão, Vasco Vieira; Organ, Vasili; Pereira, Luís; Vale, Esmeralda; Correia, Suzete

2008-01-01T23:59:59.000Z

248

A Century of Progress: Milestones in Sickle Cell Disease  

E-Print Network [OSTI]

A Century of Progress: Milestones in Sickle Cell Disease Research and Care Introduction In 1910 to be known as sickle cell disease. One hundred years later we know that the sickle-shaped cells are due take the characteristic "C"-shape that is the hallmark of sickle cell disease. What is Sickle Cell

Bandettini, Peter A.

249

Harvesting can increase severity of wildlife disease epidemics  

E-Print Network [OSTI]

Harvesting can increase severity of wildlife disease epidemics Marc Choisy1,* and Pejman Rohani1 extinction. Surprisingly, infectious diseases have not been accounted for in harvest models, which is a major and harvesting can substantially increase both disease prevalence and the absolute number of infectious

250

PRINCIPAL DISEASES OF COMMERCIALLY IMPORTANT MARINE BIVALVE MOLLUSCA AND CRUSTACEA  

E-Print Network [OSTI]

of disease-resistant strains of shellfish, environmental manipulation (dredging of grow. ing areas, chemical has ex- panded, it has become evident that disease, among other environmental variables, can drasPRINCIPAL DISEASES OF COMMERCIALLY IMPORTANT MARINE BIVALVE MOLLUSCA AND CRUSTACEA By Carl J

251

Disparities in Emergency Department Quality of Care among Patients with and without Coronary Heart Disease Diagnoses  

E-Print Network [OSTI]

coronary heart disease and heart attack, and perceive theyheart disease and heart attack, and tend to perceive thatfor heart disease and heart attack, and do not recognize

Sammartinova, Jitka

2013-01-01T23:59:59.000Z

252

Impact of Palivizumab on RSV Hospitalizations for Children with Hemodynamically Significant Congenital Heart Disease  

E-Print Network [OSTI]

in infants with congenital heart disease. Pediatrics 114:children with congenital heart disease. The Cardiac StudySigni?cant Congenital Heart Disease Ruey-Kang R. Chang •

Chang, Ruey-Kang R.; Chen, Alex Y.

2010-01-01T23:59:59.000Z

253

Smoking and Ischemic Heart Disease Disparities Between Studies, Genders, Times, and Socioeconomic Strata  

E-Print Network [OSTI]

predictors of coronary heart disease among women. Americanon the risk for coronary heart disease even stronger thanx Smoking and Ischemic Heart Disease Disparities Between

Leistikow, Bruce N.

2009-01-01T23:59:59.000Z

254

E-Print Network 3.0 - acute diarrhoeal disease Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

(collectively) the diarrhoeal diseases. Each... .4. Diarrhoeal diseases 4.4.1. Deprive resources needed to fight disease The most common fatal complication... arising from...

255

E-Print Network 3.0 - advanced eye disease Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Safety PRogRam Summary: . Leptospirosis Leptospirosis is a bacterial disease that causes abortion, eye problems and kidney disease... Horse Transmitted DiseasesSaddle Up SAFELY...

256

E-Print Network 3.0 - acute kawasaki disease Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Nile Virus and Encephalitis; Kawasaki disease that may be transmitted by an unknown... problems. Vector borne diseases and Kawasaki Disease are two areas CAPCCCC are currently...

257

Analysis of Dose Response for Circulatory Disease After Radiotherapy for Benign Disease  

SciTech Connect (OSTI)

Purpose: To assess the shape of the dose-response for various circulatory disease endpoints, and modifiers by age and time since exposure. Methods and Materials: This was an analysis of the US peptic ulcer data testing for heterogeneity of radiogenic risk by circulatory disease endpoint (ischemic heart, cerebrovascular, other circulatory disease). Results: There were significant excess risks for all circulatory disease, with an excess relative risk Gy{sup -1} of 0.082 (95% CI 0.031-0.140), and ischemic heart disease, with an excess relative risk Gy{sup -1} of 0.102 (95% CI 0.039-0.174) (both p = 0.01), and indications of excess risk for stroke. There were no statistically significant (p > 0.2) differences between risks by endpoint, and few indications of curvature in the dose-response. There were significant (p < 0.001) modifications of relative risk by time since exposure, the magnitude of which did not vary between endpoints (p > 0.2). Risk modifications were similar if analysis was restricted to patients receiving radiation, although the relative risks were slightly larger and the risk of stroke failed to be significant. The slopes of the dose-response were generally consistent with those observed in the Japanese atomic bomb survivors and in occupationally and medically exposed groups. Conclusions: There were excess risks for a variety of circulatory diseases in this dataset, with significant modification of risk by time since exposure. The consistency of the dose-response slopes with those observed in radiotherapeutically treated groups at much higher dose, as well as in lower dose-exposed cohorts such as the Japanese atomic bomb survivors and nuclear workers, implies that there may be little sparing effect of fractionation of dose or low-dose-rate exposure.

Little, Mark P., E-mail: mark.little@nih.gov [Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza South, Rockville, Maryland (United States); Kleinerman, Ruth A. [Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza South, Rockville, Maryland (United States)] [Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza South, Rockville, Maryland (United States); Stovall, Marilyn; Smith, Susan A. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Mabuchi, Kiyohiko [Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza South, Rockville, Maryland (United States)] [Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza South, Rockville, Maryland (United States)

2012-12-01T23:59:59.000Z

258

A study of the pecan shuck disease  

E-Print Network [OSTI]

29 Micro. 28 + Macro. 27 10 11 Cyprex 12 33 Mi cro . 34 + Zinc 35 36 37 Zinc 38 26 25 24 23 22 21 Micro. Cyprex + Macro. 13 Cyprex 14 + Micro. 15 16 Cyprex 17 + Zinc 18 0 I a 'o tU 4J m w 4J o 39 20 19... in the study of the effect of various treatments on the incidence of pecan shuck disease. 12 Fig. 3-3. John Bean sprayer used to make the foliar applications of zinc, Cyprex fungicide and microelements. A) Front view, B) Side view. 13 Table 3...

Williams, James Mclaren

1969-01-01T23:59:59.000Z

259

Chemicals for Plant Disease Control at Home  

E-Print Network [OSTI]

name/type Product name Brand T/O V F 1. biological Serenade Garden Disease Control Agraquest y y y 2. botanical Lawn & Turf Fungicide Garlic GP y n n E-rase RTU Monterey y y y Organic Rose & Flower Spray Greenlight y n n Paradigm Parkway Research y n n... product Oil and Lime Sulfur Bonide y n y 8. mancozeb Mancozeb Flowable Bonide y y n Dithane M-45 Southern Ag y y n 9. maneb Maneb Garden Fungicide Hi-Yield y y n 10. myclobutanil F-Stop Fertilome y n n Fung-Away Systemic Lawn Fungicide Granules Greenlight...

Ong, Kevin

2007-10-30T23:59:59.000Z

260

diseases based upon common toxicogenomic profiles at CTD  

E-Print Network [OSTI]

The Comparative Toxicogenomics Database (CTD) is a free resource that describes chemical-gene-disease networks to help understand the effects of environmental exposures on human health. The database contains more than 13,500 chemical-disease and 14,200 gene-disease interactions. In CTD, chemicals and genes are associated with a disease via two types of relationships: as a biomarker or molecular mechanism for the disease (M-type) or as a real or putative therapy for the disease (T-type). We leveraged these curated datasets to compute similarity indices that can be used to produce lists of comparable diseases (“DiseaseComps”) based upon shared toxicogenomic profiles. This new metric now classifies diseases with common molecular characteristics, instead of the traditional approach of using histology or tissue of origin to define the disorder. In the dawning era of “personalized medicine”, this feature provides a new way to view and describe diseases and will help develop testable hypotheses about chemical-gene-disease networks. Availability: CTD is freely available at

Allan Peter Davis; Michael C. Rosenstein; Thomas Conrad Wiegers; Carolyn J. Mattingly

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

E-Print Network 3.0 - adult kawasakis disease Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Starvation nutritional deficiencies Concurrent diseasesConcurrent diseases Poor immunoglobulin levelsPoor immunoglobulin... facilities RenderedRendered--product...

262

FISH CONSUMPTION, METHYLMERCURY, AND HUMAN HEART DISEASE.  

SciTech Connect (OSTI)

Environmental mercury continues to be of concern to public health advocates, both in the U.S. and abroad, and new research continues to be published. A recent analysis of potential health benefits of reduced mercury emissions has opened a new area of public health concern: adverse effects on the cardiovascular system, which could account for the bulk of the potential economic benefits. The authors were careful to include caveats about the uncertainties of such impacts, but they cited only a fraction of the applicable health effects literature. That literature includes studies of the potentially harmful ingredient (methylmercury, MeHg) in fish, as well as of a beneficial ingredient, omega-3 fatty acids or ''fish oils''. The U.S. Food and Drug Administration (FDA) recently certified that some of these fat compounds that are primarily found in fish ''may be beneficial in reducing coronary heart disease''. This paper briefly summarizes and categorizes the extensive literature on both adverse and beneficial links between fish consumption and cardiovascular health, which are typically based on studies of selected groups of individuals (cohorts). Such studies tend to comprise the ''gold standard'' of epidemiology, but cohorts tend to exhibit a great deal of variability, in part because of the limited numbers of individuals involved and in part because of interactions with other dietary and lifestyle considerations. Note that eating fish will involve exposure to both the beneficial effects of fatty acids and the potentially harmful effects of contaminants like Hg or PCBs, all of which depend on the type of fish but tend to be correlated within a population. As a group, the cohort studies show that eating fish tends to reduce mortality, especially due to heart disease, for consumption rates up to about twice weekly, above which the benefits tend to level off. A Finnish cohort study showed increased mortality risks in the highest fish-consuming group ({approx}3 times/wk), which had mercury exposures (mean hair content of 3.9 ppm) much higher than those seen in the United States. As an adjunct to this cursory review, we also present some new ''ecological'' analyses based on international statistics on hair Hg, fish consumption, other dietary and lifestyle factors, and selected cardiovascular health endpoints. We searched for consistent differences between primarily fish-consuming nations, like Japan or the Seychelles, and others who traditionally eat much less fish , such as in central Europe, for example. We use data on cigarette sales, smoking prevalence surveys, and national lung cancer mortality rates to control for the effects of smoking on heart disease. These ecological analyses do not find significant adverse associations of either fish consumption or hair Hg with cardiovascular health; instead, there is a consistent trend towards beneficial effects, some of which are statistically significant. However, such ecological studies cannot distinguish differences due to variations in individual rates of fish consumption. We conclude that the extant epidemiological evidence does not support the existence of significant heart disease risks associated with mercury in fish, for the United States. The most prudent advice would continue to be that of maintaining a well-balanced diet, including fish or shellfish at least once per week. There may be additional benefits from fatty fish.

LIPFERT, F.W.; SULLIVAN, T.M.

2005-09-21T23:59:59.000Z

263

Chronic Beryllium Disease Prevention Program Report  

SciTech Connect (OSTI)

This document describes how Lawrence Livermore National Laboratory (LLNL) meets the requirements and management practices of federal regulation 10 CFR 850, 'Chronic Beryllium Disease Prevention Program (CBDPP).' This revision of the LLNL CBDPP incorporates clarification and editorial changes based on lessons learned from employee discussions, observations and reviews of Department of Energy (DOE) Complex and commercial industry beryllium (Be) safety programs. The information is used to strengthen beryllium safety practices at LLNL, particularly in the areas of: (1) Management of small parts and components; and (2) Communication of program status to employees. Future changes to LLNL beryllium activities and on-going operating experience will be incorporated into the program as described in Section S, 'Performance Feedback.'

Lee, S

2012-03-29T23:59:59.000Z

264

Infectious Disease Proteome Biomarkers: Final Technical Report  

SciTech Connect (OSTI)

Research for the DOE Infectious Disease Proteome Biomarkers focused on Rift Valley fever virus (RVFV) and Venezuelan Equine Encephalitis Virus (VEEV). RVFV and VEEV are Category A and B pathogens respectively. Among the priority threats, RVFV and VEEV rank high in their potential for being weaponized and introduced to the United States, spreading quickly, and having a large health and economic impact. In addition, they both have live attenuated vaccine, which allows work to be performed at BSL-2. While the molecular biology of RVFV and VEEV are increasingly well-characterized, little is known about its host-pathogen interactions. Our research is aimed at determining critical alterations in host signaling pathways to identify therapeutics targeted against the host.

Bailey, Charles L.

2011-12-31T23:59:59.000Z

265

Respiratory disease in Utah coal miners  

SciTech Connect (OSTI)

Two hundred forty-two Utah underground coal miners volunteered to participate in a respiratory disease study. They were an older group (mean, 56 years of age) and had spent a mean of 29 years in the coal-mining industry. The prevalence of chronic bronchitis was 57%, and that of coal worker's pneumoconiosis, 25%; only one worker had progressive massive fibrosis. Significant impairment of pulmonary function was found among those with a history of cigarette smoking. Chronic bronchitis or coal worker's penumoconiosis among nonsmokers did not impair pulmonary function. There was a significant association among the nonsmokers between increasing exposure to coal dust and coal worker's pneumoconiosis, but not for changes in pulmonary function. Coal mine dust had a significant influence in causing the symptom complex of chronic cough and sputum production, and coal worker's pneumoconiosis.

Rom, W.N.; Kanner, R.E.; Renzetti, A.D. Jr.; Shigeoka, J.W.; Barkman, H.W.; Nichols, M.; Turner, W.A.; Coleman, M.; Wright, W.E.

1981-04-01T23:59:59.000Z

266

Respiratory disease in Utah coal miners  

SciTech Connect (OSTI)

Two hundred forty-two Utah underground coal miners volunteered to participate in a respiratory disease study. They were an older group (mean, 56 years of age) and had spent a mean of 29 years in the coal-mining industry. The prevalence of chronic bronchitis was 57%, and that of coal worker's pneumoconiosis, 25%; only one worker had progressive massive fibrosis. Significant impairment of pulmonary function was found among those with a history of cigarette smoking. Chronic bronchitis or coal worker's pneumoconiosis among nonsmokers did not impair pulmonary function. There was a significant association among the nonsmokers between increasing exposure to coal dust and coal worker's pneumoconiosis, but not for changes in pulmonary function. Coal mine dust had a significant influence in causing the symptom complex of chronic cough and sputum production, and coal worker's pneumoconiosis.

Rom, W.N.; Kanner, R.E.; Renzetti, A.D. Jr.; Shigeoka, J.W.; Barkman, H.W.; Nichols, M.; Turner, W.A.; Coleman, M.; Wright, W.E.

1981-04-01T23:59:59.000Z

267

Automated diagnostic kiosk for diagnosing diseases  

DOE Patents [OSTI]

An automated and autonomous diagnostic apparatus that is capable of dispensing collection vials and collections kits to users interesting in collecting a biological sample and submitting their collected sample contained within a collection vial into the apparatus for automated diagnostic services. The user communicates with the apparatus through a touch-screen monitor. A user is able to enter personnel information into the apparatus including medical history, insurance information, co-payment, and answer a series of questions regarding their illness, which is used to determine the assay most likely to yield a positive result. Remotely-located physicians can communicate with users of the apparatus using video tele-medicine and request specific assays to be performed. The apparatus archives submitted samples for additional testing. Users may receive their assay results electronically. Users may allow the uploading of their diagnoses into a central databank for disease surveillance purposes.

Regan, John Frederick; Birch, James Michael

2014-02-11T23:59:59.000Z

268

Optical detection dental disease using polarized light  

DOE Patents [OSTI]

A polarization sensitive optical imaging system is used to detect changes in polarization in dental tissues to aid the diagnosis of dental disease such as caries. The degree of depolarization is measured by illuminating the dental tissue with polarized light and measuring the polarization state of the backscattered light. The polarization state of this reflected light is analyzed using optical polarimetric imaging techniques. A hand-held fiber optic dental probe is used in vivo to direct the incident beam to the dental tissue and collect the reflected light. To provide depth-resolved characterization of the dental tissue, the polarization diagnostics may be incorporated into optical coherence domain reflectometry and optical coherence tomography (OCDR/OCT) systems, which enables identification of subsurface depolarization sites associated with demineralization of enamel or bone.

Everett, Matthew J. (Livermore, CA); Colston, Jr., Billy W. (Livermore, CA); Sathyam, Ujwal S. (Livermore, CA); Da Silva, Luiz B. (Danville, CA); Fried, Daniel (San Francisco, CA)

2003-01-01T23:59:59.000Z

269

Does aluminum smelting cause lung disease  

SciTech Connect (OSTI)

The evidence concerning a relationship between work in the aluminum industry and lung disease has been reviewed using epidemiologic criteria. Adequate data on environmental exposure are rarely presented. Case series on aluminum potroom workers over the past 50 years have identified an asthmalike syndrome that appears to be due to an irritant rather than an allergic mechanism. These studies have been supported by evidence of within shift variability of measures of lung function. However, to date, there is inadequate evidence to resolve the question of whether potroom exposure initiates asthma or merely precipitates asthmalike symptoms in a predisposed individual. Cross-sectional studies have demonstrated evidence of reduced lung function, consistent with chronic airflow limitation. In exposed aluminum smelter workers compared to unexposed control subjects. Cigarette smoking, the major potential confounding variable, has been measured and accounted for in multivariate analyses. To date, evidence is lacking from longitudinal studies about the development of disabling chronic obstructive lung disease. Exposure to coal tar pitch volatiles in the production and consumption of anodes has biologic plausibility for an association of lung cancer with work in an aluminum smelter. Although retrospective mortality studies have failed to account for the probable high prevalence of smoking in blue collar workers, the relative risk of lung cancer is very low if present at all. Pulmonary fibrosis has not been shown to be a significant problem in aluminum smelter workers. Future research in the aluminum industry needs to concentrate on longitudinal studies, preferably with an inception cohort for the investigation of potroom asthma. 92 references.

Abramson, M.J.; Wlodarczyk, J.H.; Saunders, N.A.; Hensley, M.J.

1989-04-01T23:59:59.000Z

270

Genomics of emerging infectious disease: A PLoS collection.  

E-Print Network [OSTI]

Origins and evolutionary genomics of the 2009 swine-originan Infectious Diseases Genomics Project predict and preventRavel J (2009) The role of genomics in the identification,

Eisen, Jonathan A; MacCallum, Catriona J

2009-01-01T23:59:59.000Z

271

ORNL, UTGSM study compares structures of Huntington's disease...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

ORNL, UTGSM study compares structures of Huntington's disease protein Researchers used neutron scattering experiments to clarify structural differences between the normal (left)...

272

Strategies of survival; lectures on population, disease, war, famine  

E-Print Network [OSTI]

Lectures on the theories of Malthus, and on disease, war and famine, including theories of McKeown, Adam Smith and Amartya Sen...

Macfarlane, Alan

2007-02-14T23:59:59.000Z

273

aleutian disease virus: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

cause diseases with long incubation periods, insidious onsets, and slowly progressive courses (1). The members of the virus group include visna virus of sheep, caprine...

274

LANL spinoff receives NIH grant for respiratory disease diagnostic...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

LANL spinoff receives NIH grant LANL spinoff receives NIH grant for respiratory disease diagnostic device Mesa Tech has been awarded a grant to develop an inexpensive,...

275

adnexal diseases: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

diseases Ulcer treatment has been revolutionized by recently discovered knowledge about Helicobacter pylori, a bacterium commonly found in the human gastrointestinal tract. These...

276

avium complex disease: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Characterizing SNP-Disease Associations Using Bayesian Networks University of Kansas - KU ScholarWorks Summary: of computational methods in epistatic interaction...

277

E-Print Network 3.0 - atherosclerotic cardiovascular disease...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the molecular Summary: .Riou@ujf-grenoble.fr > LMR and AB equally contributed to this work Abstract Cardiovascular diseases (CVD) are the leading... ; vulnerable coronary...

278

Do changes in traditional coronary heart disease risk factors over time explain the association between socio-economic status and coronary heart disease?  

E-Print Network [OSTI]

case-control study. Heart 2009, Franks P, Tancredi DJ,status in coronary heart disease risk estimation. Ann Famstatus and coronary heart disease risk prediction. JAMA

Franks, Peter; Winters, Paul C; Tancredi, Daniel J; Fiscella, Kevin A

2011-01-01T23:59:59.000Z

279

Inherited Neuronal Ion Channelopathies: New Windows on Complex Neurological Diseases  

E-Print Network [OSTI]

cause of these diseases. Key words: sodium channels; calcium channels; epilepsy; migraine; pain; genetic diseases Introduction Voltage-gated sodium and calcium channels are closely related members of the ion­IV), which each consists of six -helical trans- membrane segments (S1­S6) and a pore loop connecting S5 and S

Meisler, Miriam

280

Harnessing plasticity to understand learning and treat disease  

E-Print Network [OSTI]

Harnessing plasticity to understand learning and treat disease Michael P. Kilgard The University, USA A large body of evidence suggests that neural plasticity contributes to learning and disease. Recent studies sug- gest that cortical map plasticity is typically a transient phase that improves

Kilgard, Michael P.

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Diseases of plantation forestry trees in eastern and southern Africa  

E-Print Network [OSTI]

Diseases of plantation forestry trees in eastern and southern Africa J. Roux a*, G. Meke b , B are being allocated to the training of forestry staff andtreeimprovement.Theseefforts,aimedatstrengtheningthe forestry business, also embrace research on pests and diseases that might significantly reduce the value

282

Arsenic in drinking water Increases mortality from cardiovascular disease  

E-Print Network [OSTI]

Arsenic in drinking water Increases mortality from cardiovascular disease Allan H Smith professor of inorganic arsenic in drinking water causes cancer of the skin, bladder, lung, liver, and kidney.1 2 Mounting of a link between cardiovascular disease and arsenic in drinking water came in 1980 from Antofagasta, Chile

California at Berkeley, University of

283

Asbestos-related pulmonary disease in boilermakers  

SciTech Connect (OSTI)

Boilermakers are skilled building tradesmen who construct, repair, and dismantle boilers. The present study reports on the evaluation of members of a Michigan boilermaker's union for the presence of signs and symptoms of chronic pulmonary disease. Study variables included standardized evaluations of chest x-ray findings, pulmonary function testing, physical examination, and respiratory symptoms. An overall participation rate of 69% was achieved. A non-participant survey identified no significant differences between participants and non-participants in dyspnea, cough, age, or smoking history. Among participants with greater than 20 years experience in the trade, the mean FVC was 91% of predicted; the FEV1 was 86% of predicted; 25% showed at least a 1/0 profusion of interstitial markings on chest x-ray; 30% had bilateral pleural abnormalities; and 52% had audible inspiratory rales on physical examination. Forced vital capacity and forced expiratory volume at one second both decreased with years in the trade. Chest x-ray findings of interstitial fibrosis and pleural plaques were related to ten or more years in the trade, as were respiratory symptoms of pulmonary rales, wheeze, and dyspnea.

Demers, R.Y.; Neale, A.V.; Robins, T.; Herman, S.C. (Wayne State Univ., Detroit, MI (USA))

1990-01-01T23:59:59.000Z

284

antimicrobial peptides isolated: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

has attracted surprisingly Maurice Charlet; Serguey Chernysh; Charles Hetru; Jules A. Hoffmann 2 Alzheimer's Disease Antimicrobial Peptides Mathematics Websites Summary: Keywords...

285

antimicrobial peptide isolated: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

has attracted surprisingly Maurice Charlet; Serguey Chernysh; Charles Hetru; Jules A. Hoffmann 2 Alzheimer's Disease Antimicrobial Peptides Mathematics Websites Summary: Keywords...

286

Please contact Susan Gordon, Research Information Specialist, at gordosc@mcmaster.ca or extension 23138 if you would like to subscribe/unsubscribe to the Funding Opportunities Bulletin mailing list or if you would like assistance searching for  

E-Print Network [OSTI]

, Linda Crnic Institute for Down Syndrome and the Global Down Syndrome Foundation: Understanding the Development and Devising Treatments for Alzheimer's Disease in Individuals with Down Syndrome ­ Letter

Haykin, Simon

287

Modeling of Mitochondria Bioenergetics Using a Composable Chemiosmotic Energy Transduction Rate Law: Theory and Experimental Validation  

E-Print Network [OSTI]

2010) Modeling mitochondrial bioenerget- ics with integrated2009) Mitochondrial bioenergetic deficit precedes alzheimer’diseases. Journal of Bioenergetics and Biomembranes 40: 59–

Chang, Ivan; Heiske, Margit; Letellier, Thierry; Wallace, Douglas; Baldi, Pierre

2011-01-01T23:59:59.000Z

288

E-Print Network 3.0 - ad modifies clinicopathological Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

sever- ity of Alzheimer disease ... Source: Columbia University, Taub Institute, Cognitive Neuroscience Division Collection: Biology and Medicine 2 Therapeutics, Targets, and...

289

apolipoprotein a-i significance: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Parasuraman, Raja 23 Prospective Memory and Apolipoprotein E in Healthy Aging and Early Stage Alzheimer's Disease Biology and Medicine Websites Summary: Prospective Memory and...

290

E-Print Network 3.0 - antioxidant cocktail supplementation Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

a mouse model of Alzheimer's ... Source: Wisconsin at Madison, University of - Solar Energy Laboratory Collection: Renewable Energy 54 Neurobiology of Disease Nrf2 Activation in...

291

nAture methods | VOL.10 NO.2 | FEBRUARY2013 | 147 measurement of protease activity in living cells or organisms  

E-Print Network [OSTI]

, such as gout6, atherosclerosis7, type 2 diabetes8 and Alzheimer's disease9, engagement of the NLRP3­ASC

Cai, Long

292

Statistical shape analysis of neuroanatomical structures based on spherical wavelet transformation  

E-Print Network [OSTI]

Evidence suggests that morphological changes of neuroanatomical structures may reflect abnormalities in neurodevelopment, or relate to a variety of disorders, such as schizophrenia and Alzheimer's disease (AD). Advances ...

Yu, Peng, Ph. D. Massachusetts Institute of Technology

2008-01-01T23:59:59.000Z

293

Adapting ADA Architectural Design Knowledge to Product Design: Groundwork for a Function Based Approach  

E-Print Network [OSTI]

and 4th digits come as a pair. For example, b 7 is neuromusculoskeletal and movement related functions, where b750 to b789 cover movement functions; b750 is motor reflex functions, b760 is control of voluntary movements, b7601 is control of complex.... (August 2010) Shraddha Chandrakant Sangelkar, B. Tech., Veermata Jijabai Technological Institute, India Chair of Advisory Committee: Dr. Daniel A. McAdams Disability is seen as a result of an interaction between a person and that person...

Sangelkar, Shraddha Chandrakant

2011-10-21T23:59:59.000Z

294

ada-europe international conference: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Fuels Websites Summary: , Simulation and Environmental Impact of Energy systems turku Finland Call for Papers ECOS2014- 27th International Conference on Efficiency, Cost,...

295

ada-deficient severe combined: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

James A Zwiebel; Eli Gilboa; R Michael Blaese; Arthur Nienhuis; Richard J O& apos; reilly; W. French Anderson 1987-01-01 12 Spatial joins are one of the most important...

296

Long Range Campus Development Plan ADA The abbreviation for Americans with Disabilities Act.  

E-Print Network [OSTI]

is the student government association serving as the elected voice of the students of Montana State University to simultaneously generate both electricity and useful heat. Districts A district is an area of concentrated similar The abbreviation for the Facilities Planning, Design and Construction department within University Services. FTE

Maxwell, Bruce D.

297

E-Print Network 3.0 - ada holcar slovenia Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Department - Wood Energy WISDOM - Slovenia Spatial woodfuel production... Slovenia Forest Service Based on: the work carried out in the framework of the FAOGovernment of...

298

E-Print Network 3.0 - ada accessibility guidelines Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Source: Texas at Austin, University of - Center for Transportation Research Collection: Energy Storage, Conversion and Utilization 54 THE NEWSLETTER OF CAMPUS DIVERSITY 1 2 A...

299

E-Print Network 3.0 - ada2p yields insight Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

up to 70 %-wt. In this process, the biomass is heated to temperatures of 400... hydrotreating catalysts with respect to oil yield (up to 60 %-wt.) and deoxygenation level (up...

300

Ada County, Idaho ASHRAE 169-2006 Climate Zone | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home5b9fcbce19 NoPublic Utilities Address: 160 East 300 SouthWaterBrasil Jump to: navigation,Diagram Jump

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Molecular Biology of the Cell Vol. 18, 38353844, October 2007  

E-Print Network [OSTI]

phosphorylation of APP is a pathological trait of Alzheimer's disease. APP is overexpressed in Down's syndrome's disease and Down's syndrome--in the context of normal neuronal func- tion and during degeneration and tau (Selkoe, 2001). Patients with Down's syndrome also develop Alzheimer's disease pathology

Muresan, Virgil

302

Inefficient degradation of truncated polyglutamine proteins by the proteasome  

E-Print Network [OSTI]

Comprehensive Cancer Center, Northwestern University, Evanston, IL, USA Accumulation of mutant proteins of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and the polygluta- mine disorders that cells expressing mutant ataxin-1 or Huntingtin exhibit decreased proteasome activity

Matouschek, Andreas

303

O R E G O N of the Hanford Thyroid Disease Study  

E-Print Network [OSTI]

WASHINGTON O R E G O N IDAHO HANFORD Summary of the Hanford Thyroid Disease Study Summary of the Hanford Thyroid Disease Study Final Report F I N A L R E P O R T AbouttheHanfordThyroidDiseaseStudy(HTDS) The Hanford Thyroid Disease Study (HTDS) is a study of thyroid disease among people who were exposed

304

Particulate matter and heart disease: Evidence from epidemiological studies  

SciTech Connect (OSTI)

The association between particulate matter and heart disease was noted in the mid-nineties of last century when the epidemiological evidence for an association between air pollution and hospital admissions due to cardiovascular disease accumulated and first hypotheses regarding the pathomechanism were formulated. Nowadays, epidemiological studies have demonstrated coherent associations between daily changes in concentrations of ambient particles and cardiovascular disease mortality, hospital admission, disease exacerbation in patients with cardiovascular disease and early physiological responses in healthy individuals consistent with a risk factor profile deterioration. In addition, evidence was found that annual average PM{sub 2.5} exposures are associated with increased risks for mortality caused by ischemic heart disease and dysrhythmia. Thereby, evidence is suggesting not only a short-term exacerbation of cardiovascular disease by ambient particle concentrations but also a potential role of particles in defining patients' vulnerability to acute coronary events. While this concept is consistent with the current understanding of the factors defining patients' vulnerability, the mechanisms and the time-scales on which the particle-induced vulnerability might operate are unknown.

Peters, Annette [GSF-National Research Center for Environment and Health, Institute of Epidemiology, Ingolstaedter Landstr. 1, 85764 Neuherberg (Germany)]. E-mail: peters@gsf.de

2005-09-01T23:59:59.000Z

305

Red Blood cell Alloimmunization in Sickle Cell Disease: Pathophysiology, Risk Factors, and Transfusion Management  

E-Print Network [OSTI]

1 Red Blood cell Alloimmunization in Sickle Cell Disease: Pathophysiology, Risk Factors; email: france.noizat-pirenne@efs.sante.fr Keywords: sickle cell disease, alloimmunization, DHTR with sickle cell disease (SCD). Transfusions can lead to erythrocyte alloimmunization, however, with serious

Boyer, Edmond

306

Medicating race : heart disease and durable preoccupations with difference  

E-Print Network [OSTI]

This dissertation is an examination of intersections of race, pharmaceuticals, and heart disease over the course of the 20th century and today. Each of these parts has had a dynamic history, and when they are invoked ...

Pollock, Anne, 1975-

2007-01-01T23:59:59.000Z

307

Real-time Raman system for in vivo disease diagnosis  

E-Print Network [OSTI]

Raman spectroscopy has been well established as a powerful in vitro method for studying biological tissue and diagnosing disease. The recent development of efficient, high-throughput, low-background optical fiber Raman ...

Motz, Jason T.

308

Quantitative Neuroimaging : : Applications to Normal Aging and Neurodegenerative Disease  

E-Print Network [OSTI]

and metabolism of lipoproteins. Ann Endocrinol 44(1), 59-65.Disease by Elizabeth Ann Murphy Doctor of Philosophy ina tale of two proteins. Ann Neurol. 2006;59(3);449-458.

Murphy, Elizabeth Ann

309

Striatal origin of the pathologic beta oscillations in Parkinson's disease  

E-Print Network [OSTI]

Enhanced oscillations at beta frequencies (8–30 Hz) are a signature neural dynamic pathology in the basal ganglia and cortex of Parkinson's disease patients. The mechanisms underlying these pathological beta oscillations ...

Boyden, Edward Stuart

310

Modelling power-law spread of infectious diseases  

E-Print Network [OSTI]

Short-time human travel behaviour can be well described by a power law with respect to distance. We incorporate this information in space-time models for infectious disease surveillance data to better capture the dynamics of disease spread. Two previously established model classes are extended, which both decompose disease risk additively into endemic and epidemic components: a space-time point process model for individual point-referenced data, and a multivariate time series model for aggregated count data. In both frameworks, the power-law spread is embedded into the epidemic component and its decay parameter is estimated simultaneously with all other unknown parameters using (penalised) likelihood inference. The performance of the new approach is investigated by a re-analysis of individual cases of invasive meningococcal disease in Germany (2002-2008), and count data on influenza in 140 administrative districts of Southern Germany (2001-2008). In both applications, the power-law formulations substantially ...

Meyer, Sebastian

2013-01-01T23:59:59.000Z

311

Collaborative Help in Chronic Disease Management: Supporting Individualized Problems  

E-Print Network [OSTI]

Collaborative Help in Chronic Disease Management: Supporting Individualized Problems ABSTRACT for how diabetes patient support groups help one another find individualized strategies for managing diabetes community, and interviews, we found several help interactions that are critical in helping

Anderson, Richard

312

A biophysical marker of severity in sickle cell disease  

E-Print Network [OSTI]

The search for predictive indicators of disease has largely focused on molecular markers. However, biophysical markers, which can integrate multiple pathways, may provide a more global picture of pathophysiology. Sickle ...

Mahadevan, L.

313

452 Plant Disease / Vol. 82 No. 5 A. R. Biggs  

E-Print Network [OSTI]

452 Plant Disease / Vol. 82 No. 5 A. R. Biggs West Virginia University, Kearneysville G. G. Grove-illustrated "fact sheets" Dr. Biggs' address is: West Virginia University, University Experiment Farm, P. O. Box 609

Biggs, Alan R.

314

Status Report, Department of Energy's Chronic Beryllium Disease...  

Broader source: Energy.gov (indexed) [DOE]

of 10 C.F.R. Part 850, Chronic Beryllium Disease Prevention Program, at the Department of Energy (DOE). The report is based on the results of evaluations of the effectiveness of...

315

CENTERS FOR DISEASE CONTROL ,,~V'CIl'1I  

E-Print Network [OSTI]

EXECUTIVESECRETARY Houk, Vernon N., M.D. Director Center for Environmental Health Centers for Disease Conlrol Atlanla Hahnemann UniversilY Broad and Vine Streets Philadelphia, Pennsylvania 19102 Cole, Jerome F., S

316

artery disease involving: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

E. Lundquist; James P. Ward 72 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

317

autoimmune disease triggered: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

disease (PD), to date there is still no definite cause or accepted treatment Hlava, Debbie Joy 2012-01-01 44 One (1) Postdoctoral position available at IMBB-FORTH, Heraklion,...

318

artery disease evaluation: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

GIUSEPPE, RACHELE 2012-01-01 53 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

319

artery disease studied: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

pressure Hielscher, Andreas 8 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

320

artery disease selection: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Andrew J. Lees 1991-01-01 56 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

arterial occlusive disease: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

have Chen, Yiling 65 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

322

artery disease potential: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

fo... Yi, Li Ting 2013-01-01 56 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

323

artery disease comparison: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

have Chen, Yiling 45 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

324

artery disease assessed: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

have Chen, Yiling 60 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

325

arterial occlusive diseases: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

have Chen, Yiling 65 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

326

artery disease outcomes: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

have Chen, Yiling 53 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

327

artery disease assessment: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

have Chen, Yiling 60 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

328

artery disease increased: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Mervyn J. Monteiro 1997-01-01 52 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

329

artery occlusive disease: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

have Chen, Yiling 65 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

330

artery disease evaluated: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

GIUSEPPE, RACHELE 2012-01-01 53 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

331

arterial disease study: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

pressure Hielscher, Andreas 8 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

332

arterial disease lack: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

have Chen, Yiling 42 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

333

RESEARCH OF ANIMAL DISEASE INFORMATION SYSTEM BASED ON GIS  

E-Print Network [OSTI]

RESEARCH OF ANIMAL DISEASE INFORMATION SYSTEM BASED ON GIS TECHNOLOGY Hongbin Wang *, Lin Li, Jing.1007/978-3-642-12220-0_9 #12;2 Hongbin Wang, Lin Li, Jing Dong, Danning Xu, Jing Li distribution. It is evident

Boyer, Edmond

334

Disease Ecology: Community Structure and Pathogen Dynamics [Review  

E-Print Network [OSTI]

BOOKS & MEDIA Disease Ecology: Community Structure and Pathogen Dynamics Sharon K. Collinge and Chris Ray, editors Oxford University Press, Cary, North Carolina, 2006 ISBN: 0198567073 Pages: 227; Price: US $124.50 The disciplines of community...

Peterson, A. Townsend

2007-01-01T23:59:59.000Z

335

Thiacetarsamide therapy of heartworm disease in cats: a pharmacokinetic study  

E-Print Network [OSTI]

. An idiopathic acute respiratory distress syndrome occurred in 3 of the treated cats, causing fulminant pulmonary edema, respiratory failure, and death within 1 to 3 hours after the second dose of thi acetarsamide. Administration of thi acetarsamide... OF THE LITERATURE Heartworm Disease Overview Dirof i 1 ari asi s is one of the most common infectious diseases requiring clinical evaluation and treatment in veterinary medicine. The heartworm, Di rofi lari a immiti s, is ubiquitous in both tropical...

Turner, Janet Lynn

2012-06-07T23:59:59.000Z

336

Engineering disease resistance with pectate lyase-like genes  

DOE Patents [OSTI]

A mutant gene coding for pectate lyase and homologs thereof is provided, which when incorporated in transgenic plants effect an increased level disease resistance in such plants. Also is provided the polypeptide sequence for the pectate lyase of the present invention. Methods of obtaining the mutant gene, producing transgenic plants which include the nucleotide sequence for the mutant gene and producing improved disease resistance in a crop of such transgenic plants are also provided.

Vogel, John; Somerville, Shauna

2005-03-08T23:59:59.000Z

337

Effect of Insulators on the Expression of betaAS3 in Lentiviral Gene Therapy for Sickle Cell Disease  

E-Print Network [OSTI]

al. (2001). Correction of sickle cell disease in transgenicto human bone marrow for sickle cell disease. Journal ofal. (2011). Correction of sickle cell disease in adult mice

Wherley, Jennifer Patricia

2013-01-01T23:59:59.000Z

338

E-Print Network 3.0 - acute diarrheal disease Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

fever Diarrheal disease caused by a parasite... Human Transport of Disease SARS The Cough Heard Round the World Severe ... Source: Otter, Ryan R. - Department of Biology,...

339

Rheumatic Heart Disease and Beta-hemolytic Streptococci in Salvador, Brazil: A Study of Slum Health  

E-Print Network [OSTI]

rheumatic fever and rheumatic heart disease in Africa. S Afrthe chain that links the heart to the throat? Lancet Infectchildren with rheumatic heart disease. J Thorac Cardiovasc

Tartof, Sara Yee

2010-01-01T23:59:59.000Z

340

E-Print Network 3.0 - acromegaly cushing disease Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

pigmented nodular adrenocortical disease (PPNAD). PPNAD, a rare cause of Cushing's syndrome, is due... is the most common treatment for Cushing's syndrome due to PPNAD. Disease...

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

E-Print Network 3.0 - atypical vogt-koyanagi-harada disease Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

differences in size, form, flower, fruit, foliage, and disease resistant... in the trade; these vary greatly in their aesthetic, size and shape, and disease resistance...

342

E-Print Network 3.0 - atypical kawasaki disease Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

differences in size, form, flower, fruit, foliage, and disease resistant... in the trade; these vary greatly in their aesthetic, size and shape, and disease resistance...

343

E-Print Network 3.0 - assessing disease activity Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

> >> 1 MAR 554 -DISEASES OF AQUATIC ORGANISMS (3 credits) Summary: and public health 21. Impact of natural environmental factors on diseases 22. Impact of human activities......

344

E-Print Network 3.0 - animal disease outbreaks Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sample search results for: animal disease outbreaks Page: << < 1 2 3 4 5 > >> 1 Economic Consideration of Mitigation of Foreign Animal Disease Introduction * Summary:...

345

E-Print Network 3.0 - advanced liver disease Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

useful for advancing therapeutic interventions for individuals with liver disease... diseases (e.g. hepatitis B and hepatitis C infection, toxin-induced liver failure, tyrosinemia...

346

E-Print Network 3.0 - addison disease Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and the Transmission of Infectious Diseases Summary: Tropical Environments, Human Activities, and the Transmission of Infectious Diseases LISA... host-pathogen interactions;...

347

E-Print Network 3.0 - atherosclerotic heart disease Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

heart disease Search Powered by Explorit Topic List Advanced Search Sample search results for: atherosclerotic heart disease Page: << < 1 2 3 4 5 > >> 1 Stent's unique nature may...

348

E-Print Network 3.0 - airborne infectious diseases Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Physics Investigation of airborne foot-and-mouth disease virus transmission during low-wind conditions... ) provides a more de- tailed analysis of the airborne disease...

349

Disease-Specific Symptoms and Health-Related Quality of Life in Children and Adolescents with Inflammatory Bowel Disease  

E-Print Network [OSTI]

, & Tennen, 2006). Therefore, HRQOL provides valuable information about patient outcomes in terms of successful adaptation to chronic illness (Livneh, 2001; Varni, Burwinkle, & Lane, 2005). Although HRQOL is a broad concept that may encompass a number...; Cortina, McGraw, deAlarcon, Rothenberg, & Drotar, 2010; Varni et al., 2006; Varni et al., 2007). Within the category of gastrointestinal disorders, Crohn?s disease and ulcerative colitis, two conditions subsumed under the overarching disease category...

Vaughan-Dark, Chelsea Ann

2013-07-17T23:59:59.000Z

350

Seamless Correction of the Sickle Cell Disease Mutation of the HBB Gene in Human Induced  

E-Print Network [OSTI]

Seamless Correction of the Sickle Cell Disease Mutation of the HBB Gene in Human Induced ABSTRACT: Sickle cell disease (SCD) is the most common human genetic disease which is caused by a single effector nucleases; induced pluripotent stem cells; piggyBac transposon; sickle cell disease; gene therapy

Zhao, Huimin

351

Association Between Celiac Disease and Iron Deficiency in Caucasians, but not Non-Caucasians  

E-Print Network [OSTI]

autoimmune gastritis, Helicobacter pylori and celiac diseaserole of celiac disease, helicobacter pylori, and autoimmune

2013-01-01T23:59:59.000Z

352

Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The  

E-Print Network [OSTI]

Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease contributes to the development of coronary heart disease (CHD). Soluble epoxide hydrolase metabolizes as a potential cardiovascular disease- susceptibility gene. INTRODUCTION Coronary heart disease (CHD) is a major

Hammock, Bruce D.

353

Curr Pharm Des . Author manuscript Bisphosphonates and bone diseases: past, present and future  

E-Print Network [OSTI]

involving excessive bone resorption which include post-menopausal osteoporosis, Paget s disease of bone

Paris-Sud XI, Université de

354

Detection of bone disease in dogs by radioisotope scanning  

E-Print Network [OSTI]

DETECTION OZ BONE DISEASE IN DOGS BY RADIOISOTOPE SCANNING A Thesis EARL LOUIS MORRIS Submitted to the Graduate College of Texas A8cM University in partial fulfillment of' the requirement for the degree of MASTER OP SCIENCE May 1971 Major...' Bone Disease in Dogs by Radioisotope Scanning. (May 1971) Earl Louis Morris, B. S. , Texas Ad:I University; B. S. , Texas MM University; D. V. M. , Texas A8cM University; Directed by: Dan Eightower, D. V. M. The use of radioisotope scintiscanning...

Morris, Earl Louis

1971-01-01T23:59:59.000Z

355

Fruit and Nut Disease Control Products for Use in Texas  

E-Print Network [OSTI]

and/or distributors Contents 3 Fruit and Nut Disease Control PRODUCTS FOR USE IN TEXAS By George L.Philley* his listing of chemicals to control fruit diseases is a reference for county Extension agents and fruit producers in Texas... interval in days DF ?dry flowable F ?flowable L?liquid WDG ?wettable dispersable granule WG ?wettable granule WP?wettable powder days. Example: 7* indicates a 7-day interval from last application to har- vest. At the end of the publication is a listing...

Philley, George L.

2004-02-23T23:59:59.000Z

356

Fish oil can help reduce deaths from heart disease,  

E-Print Network [OSTI]

the risk of irregu- lar heart beats -- particularly in individuals with a recent heart attack. Paul CoatesFish oil can help reduce deaths from heart disease, according to new evidence reports announced evi- dence that long-chain omega- 3 fatty acids reduce heart at- tack and other problems, re- lated

Bandettini, Peter A.

357

PEBC Breast Cancer Disease Site Group page at:  

E-Print Network [OSTI]

Evidence-based Series 8-3 was reviewed in 2011 and ARCHIVED by the Melanoma Disease Site Group (DSG) on May 20, 2011. Evidence-based Series (EBS) 8-3 ARCHIVED 2011, the resulting review report, consists of the following 5 parts:

Program In Evidence-based Care (pebc; Cancer Care Ontario (cco

2011-01-01T23:59:59.000Z

358

A Predator-Prey Model with Disease Dynamics Chris Flake  

E-Print Network [OSTI]

a diseased fish population and their predators. Analysis of the system is performed to determine among the Tilapia fish of the Salton Sea and their predator, the pelican. This model is of interest deaths not only among the fish themselves, but also in the pelican population. Studies have indicated

Logan, David

359

GUANYLATE CYCLASE-ACTIVATING PROTEINS AND RETINA DISEASE  

E-Print Network [OSTI]

in visual trans- duction that transcends to other neuronal Ca2+ homeostasis processes Keywords: Calcium, rod hyperpolarize. Open CNG 71 E. Carafoli and M. Brini (eds.), Calcium Signalling and Disease, 71­91. © 2007*, and PDE*). Deactivation of Figure 1. Negative cGMP/Ca2+ feedback loop. Light activates PDE which rapidly

Palczewski, Krzysztof

360

A Unified Framework for MR Based Disease Classification  

E-Print Network [OSTI]

A Unified Framework for MR Based Disease Classification Kilian M. Pohl1,2 and Mert R. Sabuncu2 1-hippocampal gyrus. On this small size data set, our approach, which performs classification based on the MR images with the accuracy achieved by state-of-the-art techniques in schizophrenia MRI research. 1 Introduction Thanks to in

Pohl, Kilian M.

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Rapid communication Identification of a Crohn's disease specific  

E-Print Network [OSTI]

to be due to a combination of factors involving diet, genetic background, immunological responses presented antigen, in individuals with a particular genetic back- ground may be involved in the lack that of their respective proteins appear to be useful as specific markers for unequivocally distinguishing Crohn's disease

Perreault, Jean-Pierre

362

Introduction The number of catalogued emerging infectious diseases (EIDs), and  

E-Print Network [OSTI]

). Perhaps even more immediate than these other factors are the implications of large- scale deforestation on disease emergence. The global rate of tropical deforestation appears to be increasing readily; between of deforestation in parts of Africa are near 1% per year (FAO, 2009). Deforestation is also increasing in temperate

Sehgal, Ravinder

363

Prediction and Informative Risk Factor Selection of Bone Diseases  

E-Print Network [OSTI]

data and use these integrated features to effectively predict osteoporosis and bone fractures. We; disease memory; osteoporosis; bone fracture. ! 1 INTRODUCTION Risk factor (RF) analysis based on patients on the study of osteoporosis and bone fracture prediction. Over the past few decades, osteoporosis has been

Zhang, Aidong

364

An approach for mining care trajectories for chronic diseases  

E-Print Network [OSTI]

An approach for mining care trajectories for chronic diseases Elias Egho1 ,Nicolas Jay1 , Chedy Ra of chronic patients. In this context, temporal data mining methods are promising tools, though lacking. We show the interest of our approach with the analysis of trajectories of care for colorectal cancer

Boyer, Edmond

365

Real-Time Event Extraction Infectious Disease Outbreaks  

E-Print Network [OSTI]

; potentially relevant stories are fed to an information extraction engine, whose output is used to update Yangarber roman@cs.nyu.edu ABSTRACT We describe a system for creating and automatically updating a data base of information on infectious disease outbreaks. A web crawler is used to retrieve current news stories

366

Structural Location of Disease-associated Single-nucleotide Polymorphisms  

E-Print Network [OSTI]

Structural Location of Disease-associated Single-nucleotide Polymorphisms Nathan O. Stitziel1 , Yan-synonymous single-nucleotide polymorphism (nsSNP) of genes introduces amino acid changes to proteins, and plays reserved Keywords: single-nucleotide polymorphism; alpha shape; hidden Markov model; surface pockets

Pervouchine, Dmitri D.

367

National Center for Immunization and Respiratory Diseases No More Excuses  

E-Print Network [OSTI]

to protect yourself and your family. If you miss getting your flu vaccine in the fall, make it a New Year Vaccine WrongThe flu (influenza) is a contagious disease which affects the lungs and can lead to serious protect against non-flu viruses. · Oryoumighthavebeenexposedtoflu after you got vaccinated but before

Liblit, Ben

368

Comparing Online Community Structure of Patients of Chronic Diseases  

E-Print Network [OSTI]

In this paper we compare the social network structure of people talking about Crohn's disease, Cystic Fibrosis, and Type 1 diabetes on Facebook and Twitter. We find that the Crohn's community's contributors are most emotional on Facebook and Twitter and most negative on Twitter, while the T1D community's communication network structure is most cohesive.

Maddali, Hanuma Teja; Margolis, Peter

2015-01-01T23:59:59.000Z

369

REVIEW ARTICLE Potato soil-borne diseases. A review  

E-Print Network [OSTI]

REVIEW ARTICLE Potato soil-borne diseases. A review Marie Fiers & Véronique Edel /Published online: 24 June 2011 # INRA and Springer Science+Business Media B.V. 2011 Abstract Potato crop potato and cause severe damages especially on tubers, the economically most impor- tant part of the plant

Paris-Sud XI, Université de

370

K. A. Garrett and C. M. Cox. Applied biodiversity science: Managing emerging diseases in agriculture and linked natural systems using 1 ecological principles. Pages 368-386 in Infectious disease ecology: The effects of ecosystems on disease and of disease  

E-Print Network [OSTI]

in agriculture and linked natural systems using 1 ecological principles. Pages 368-386 in Infectious disease in Agriculture and Linked Natural Systems Using Ecological Principles K. A. Garrett and C. M. Cox Summary particular crop species or genotypes are very common. Nonetheless, production agriculture is dominated

Garrett, Karen A.

371

Cross-Species Pathogen Transmission and Disease Emergence in Primates  

E-Print Network [OSTI]

to their rapidly growing human populations, close proximity to apes, and population centers with high density and Ebola, are zoonotic, having shifted from wildlife populations. Critical questions for predicting disease is greatest. We find that central Africa and Amazonia are hotspots for cross-species transmission events

Pedersen, Amy B.

372

Cancer is a genetic disease1 . Although environmental  

E-Print Network [OSTI]

Cancer is a genetic disease1 . Although environmental and other non-genetic factors have roles in many stages of tumorigenesis,it is widely accepted that cancer arises because of mutations in cancer,however,does not suffice to give rise to full-blown cancer.For progression towards malignancyandinvasion

Nowak, Martin A.

373

PUBLICATION 600-080 Fish Health and Disease  

E-Print Network [OSTI]

PUBLICATION 600-080 Fish Health and Disease Striped bass (Morone saxitilis) and hybrid striped bass these fish are commonly raised in high densities under intensive aquaculture situations (e.g., cages, ponds of the viral, bacterial, fungal, and parasitic pathogens, but the fish become increasingly susceptible

Liskiewicz, Maciej

374

Invest in Your Bones Osteoporosis--The Silent Disease  

E-Print Network [OSTI]

Invest in Your Bones Osteoporosis--The Silent Disease Leaflet 2 Osteoporosis, a painful of State Health Services, 2008). Osteoporosis is preventable and/or treatable. Accordingly, osteoporosis of height, and chronic back pain. Hip fracture, the most serious consequence of osteoporosis, threatens one

375

Selection of a multiple disease resistant runner-type peanut  

E-Print Network [OSTI]

Four F2:4 populations of peanut (Arachis hypogaea L.) resulting from the complex cross Tamrun 96 X Tx901639-3 X Sun Oleic 95R were grown in three disease nurseries over a 2 year period. Three separate selection techniques were applied to determine...

Baring, Michael Robert

2007-09-17T23:59:59.000Z

376

Plant pathology Firestop: a chemical against bacterial diseases  

E-Print Network [OSTI]

Plant pathology Firestop: a chemical against bacterial diseases of fruit trees recently available Erwinia amylovora (fire blight) in pear and apple, and Pseudomonas syringae pv persicae (bacterial dieback) was as efficient as Bordeaux mixture and less efficient than the conventional antibiotics, streptomycin

Paris-Sud XI, Université de

377

Tropical Environments, Human Activities, and the Transmission of Infectious Diseases  

E-Print Network [OSTI]

of water sources. The transmission of cholera, a water-borne disease, is related to sanitation practices decades as a consequence of large-scale agricultural development projects that have shifted the nature and quantity of water sources and potential mosquito breeding sites. Dracunculiasis is transmitted by a small

Gottgens, Hans

378

Prevalence of chronic obstructive pulmonary disease in rural women of  

E-Print Network [OSTI]

for refining disease burden assessments attributable to household biomass combustion Priscilla Johnson1 January and May 2007. COPD assessments were done using a combination of clinical examination spend !2 hours/day in the kitchen involved in cooking. Use of solid fuel was associated with higher risk

Silver, Whendee

379

esyN: Network Building, Sharing and Publishing  

E-Print Network [OSTI]

esyN: Network Building, Sharing and Publishing Daniel M. Bean1,2, Joshua Heimbach1, Lorenzo Ficorella1,2,3, Gos Micklem1,4, Stephen G. Oliver1,2, Giorgio Favrin1,2* 1Cambridge Systems Biology Centre, University of Cambridge, Cambridge, United... identifies APOE epsilon4 effectors in Alzheimer’s disease. Nature 500: 45–50. 27. Shang H, Liu G, Jiang Y, Fu J, Zhang B, et al. (2014) Pathway Analysis of Two Amyotrophic Lateral Sclerosis GWAS Highlights Shared Genetic Signals with Alzheimer’s Disease...

Bean, Daniel M.; Heimbach, Joshua; Ficorella, Lorenzo; Micklem, Gos; Oliver, Stephen G.; Favrin, Giorgio

2014-09-02T23:59:59.000Z

380

IntroductionIntroduction Mercury: Monitoring Patients with ParkinsonMercury: Monitoring Patients with Parkinson''s Diseases Disease  

E-Print Network [OSTI]

IntroductionIntroduction Mercury: Monitoring Patients with ParkinsonMercury: Monitoring Patients's Disease EvaluationEvaluation Mercury ArchitectureMercury Architecture Mercury is a wireless sensor network and disconnections Node Behavior Hardware PlatformHardware Platform Usage Scenario InternetInternet http://fiji.eecs.harvard.edu/Mercury

Chen, Yiling

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Effects of Chronic Nicotine Exposure and Lack of High Affinity Nicotinic Receptors on Cortico-Hippocampal Areas in the Aging Mouse Brain  

E-Print Network [OSTI]

performance. Epidemiology studies show that smoking is negatively correlated with the incidence of Parkinson's disease and Alzheimer's disease. Postmortem research and neuroimaging studies show that loss of nicotinic binding sites in the brain is the major...

Huang, Pei-San

2012-07-16T23:59:59.000Z

382

Sex affects health: women are different I. Body composition & metabolism  

E-Print Network [OSTI]

. Cardiovascular Disease III. Chronic Conditions A. Osteoporosis B. Autoimmune conditions C. Alzheimer's Disease-femoral fat þ Hormonal changes may increase a female's appetite þ Menopause is associated with a shift toward

Dever, Jennifer A.

383

Death signaling 1. Wang, X. The expanding role of mitochondria in apoptosis. Genes Dev 15, 2922-2933.  

E-Print Network [OSTI]

of degenerative disorders such as Alzheimer's disease, ischemic injury from stroke (heart disease), post-menopausal osteoporosis... #12;Two types of DNA fragmentation Detection of DNA fragmentation · By gel electrophoresis

Wu, Hao

384

Death signaling 1. Wang, X. The expanding role of mitochondria in apoptosis. Genes Dev 15, 2922-2933.  

E-Print Network [OSTI]

of degenerative disorders such as Alzheimer's disease, ischemic injury from stroke (heart disease), post-menopausal osteoporosis... Apoptosis-cellular suicide-programmed cell death · `active' (not passive) form of cell death

Wu, Hao

385

June 18, 2012 Symposium on Aging  

E-Print Network [OSTI]

, anemia, muscular dystrophy, and diabetes. The reasons for accelerating research into the molecular diseases of aging such as diabetes, cancer, Alzheimer's and heart disease. Today's attendees come not only

Church, George M.

386

Design of a numerical model for simulation of blood microcirculation and study of sickle cell disease  

E-Print Network [OSTI]

Sickle cell disease is nowadays one of the most challenging blood diseases, where patients suffer from both chronic and acute episodes of painful medical conditions. In particular, unpredictable crises due to blood vessel ...

Le Floch-Yin, François T. (François Thomas)

2010-01-01T23:59:59.000Z

387

Correlation of Klebsiella pneumoniae Comparative Genetic Analyses with Virulence Profiles in a Murine Respiratory Disease Model  

E-Print Network [OSTI]

Klebsiella pneumoniae is a bacterial pathogen of worldwide importance and a significant contributor to multiple disease presentations associated with both nosocomial and community acquired disease. ATCC 43816 is a well-studied ...

Fodah, Ramy A.

388

Integrated training in Cardiovascular Diseases Sponsored by the Division of Cardiology  

E-Print Network [OSTI]

and interventional procedures such as percutaneous interventions such as angioplasty and stent placement Knowlton, Division Head I. Major Diseases 1. Coronary artery disease 2. Congestive Heart Failure 3. Cardiac

Gleeson, Joseph G.

389

Fluid and structural modeling of the disease-free and atherosclerotic human carotid bifurcation  

E-Print Network [OSTI]

Cardiovascular disease is the leading cause of death in the United States. It claims more lives each year than the next 7 leading causes of death combined. Atherosclerosis is a major cause of cardiovascular disease and is ...

Younis, Hesham F. (Hesham Farouk)

2002-01-01T23:59:59.000Z

390

Ann Occup Hyg . Author manuscript Asbestos-related diseases in automobile mechanics  

E-Print Network [OSTI]

Ann Occup Hyg . Author manuscript Page /1 7 Asbestos-related diseases in automobile mechanics Abstract Purpose Automobile mechanics have been exposed to asbestos number of automobile mechanics, little is known about the non-malignant respiratory diseases observed

Paris-Sud XI, Université de

391

I N T H I S I S S U E Lyme disease communication  

E-Print Network [OSTI]

I N T H I S I S S U E · Lyme disease communication to countryside users · Providing public benefits in private woodlands, causes of wildfires in South Wales and communicating animal disease (Lyme) risks

392

E-Print Network 3.0 - acute vogt-koyanagi-harada disease Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

vogt-koyanagi-harada disease Search Powered by Explorit Topic List Advanced Search Sample search results for: acute vogt-koyanagi-harada disease Page: << < 1 2 3 4 5 > >> 1 sistent...

393

E-Print Network 3.0 - arthritis disease activity Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sample search results for: arthritis disease activity Page: << < 1 2 3 4 5 > >> 1 CURRICULUM VITAE DANIEL J. McCARTY, M.D. Summary: of Arthritis and Metabolic Diseases, Department...

394

E-Print Network 3.0 - amyloid heart disease Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

heart disease Search Powered by Explorit Topic List Advanced Search Sample search results for: amyloid heart disease Page: << < 1 2 3 4 5 > >> 1 Imaging and In Vivo Quantitation of...

395

E-Print Network 3.0 - arrhythmia-related heart disease Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

arrhythmia-related heart disease Search Powered by Explorit Topic List Advanced Search Sample search results for: arrhythmia-related heart disease Page: << < 1 2 3 4 5 > >> 1...

396

assess foot-and-mouth disease: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Physics Websites Summary: Modelling the spread of foot-and-mouth disease virus F Moutou B Durand CNEVA, Laboratoire Central-and-mouth disease is an economically important viral...

397

Three surveillance systems for describing the spatial distribution of Johne's disease seropositivity in Texas cattle  

E-Print Network [OSTI]

distribution of Johne’s disease seropositvity, based on the three surveillance systems, confirmed our hypothesis that estimation of disease distribution is dependant upon the source of surveillance samples....

Pearce, Brielle H.

2009-05-15T23:59:59.000Z

398

A common allele on chromosome 9 associated with coronary heart disease  

E-Print Network [OSTI]

M. Appleyard, European Heart Journal 3, Suppl H. , H1 (associated with Coronary Heart Disease in whites. Minor9 associated with coronary heart disease Ruth McPherson 1* ,

2007-01-01T23:59:59.000Z

399

E-Print Network 3.0 - ankylosing spondylitis disease Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

4 5 > >> 1 HLA and Disease Jean Dausset Summary: al (18) 2) As recommended by Macrae & Wright (19) 12;74 of the disease. Ankylosing spondylitis (AS... : the "illness susceptible"...

400

E-Print Network 3.0 - atheromatous cerebrovascular diseases Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Information Sciences 3 Cerebrovascular Management & Emerging Therapies Summary: 2010 Stroke & Cerebrovascular Disease Management & Emerging Therapies OCTOBER 30, 2010 ARNOLD... ,...

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

E-Print Network 3.0 - aortic valve disease Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

disease, fibrotic... aortic ... Source: Simmons, Craig A. - Department of Mechanical and Industrial Engineering, University of Toronto Collection: Engineering ; Biology and...

402

English walnut rootstocks help avoid blackline disease, but produce less than ‘Paradox’ hybrid  

E-Print Network [OSTI]

rootstock selection can help to prevent blackline infection.English walnut rootstocks help avoid blackline disease, but

Grant, Joseph A.; McGranahan, Gale H.

2005-01-01T23:59:59.000Z

403

E-Print Network 3.0 - acute coronary disease Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

under... Pediatrics, Pulmonary Medicine Improved Diagnosis and Management of Pediatric Respiratory Diseases using... , Implications and Treatment in Patients with...

404

E-Print Network 3.0 - advanced periodontal disease Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

devastating form of periodontal disease. Genetic analysis has revealed a cluster of tad genes responsible... of Actinobacillus actinomycetemcomitans. Periodontology 20,...

405

E-Print Network 3.0 - acid peptic disease Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

), asthma, chronic bronchitis, emphysema, epilepsy, gastricpeptic ulcer dis- ease, gout, ocular... and systemic hypertension, peripheral vascular disease, and stroke (ischemic...

406

E-Print Network 3.0 - allergic ocular diseases Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

), asthma, chronic bronchitis, emphysema, epilepsy, gastricpeptic ulcer dis- ease, gout, ocular... and systemic hypertension, peripheral vascular disease, and stroke (ischemic...

407

E-Print Network 3.0 - aleutian mink disease virus Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

mink lung cells... family (Borna disease ... Source: Sveriges Lantbruksuniversitet (Swedish University of Agricultural Sciences) Collection: Multidisciplinary Databases and...

408

Proposed measures for the control of three diseases of veterinary public health significance in Bolivia  

E-Print Network [OSTI]

designed to suppress or eradicate disease has been presented. Plans for the development of effective programs for control of foot-and-mouth disease, brucellosis, and rabies have been presented along with recom- mendations for utilizing a task force... manuscripts of my thesis. TABLE OF CONTENTS Page INTRODUCTION. REVIEW OF THE LITERATURE. Geography Topography. Demography. Livestock Production. 10 Foot-and-Mouth Disease. Veterinary Public Health Aspects of Foot-and-Mouth Disease. 12 Control...

Justiniano, Mario Miguel

1981-01-01T23:59:59.000Z

409

Eur Heart J. Author manuscript History of coronary heart disease and cognitive performance in midlife: the  

E-Print Network [OSTI]

Eur Heart J. Author manuscript Page /1 9 History of coronary heart disease and cognitive: Archana Singh-Manoux Abstract Aims Some studies show coronary heart for this association. Coronary heart disease is a global problem, with the risk of disease shown to increase as12

Paris-Sud XI, Université de

410

Machine Learning Algorithms for Predicting Severe Crises of Sickle Cell Disease  

E-Print Network [OSTI]

Machine Learning Algorithms for Predicting Severe Crises of Sickle Cell Disease Clara Allayous of an acute splenic sequestration crisis (ASSC), a serious symptom of sickle cell disease (SCD). Precisely, in contrast to the logistic regression approach. Keywords and phrases: sickle cell disease, ranking, ROC curve

Emilion, Richard

411

Cost-Sensitive Risk Stratification in the Diagnosis of Heart Disease  

E-Print Network [OSTI]

Cost-Sensitive Risk Stratification in the Diagnosis of Heart Disease Selen Uguroglu and Jaime Pittsburgh, PA 15212 Abstract We investigate machine learning methods for diagnos- tic screening of heart disease. Coronary heart disease is the leading cause of death in the US, causing more deaths than all

Carbonell, Jaime

412

THe heartTruTH Heart disease is the #1 killer of  

E-Print Network [OSTI]

THe heartTruTH® #12;Heart disease is the #1 killer of women, but many women do not know they are at risk. The Heart Truth® campaign aims to give women a personal and urgent wake-up call about their risk of heart disease. The red Dress® is the national symbol for women and heart disease awareness introduced

Baker, Chris I.

413

Heart . Author manuscript Effects of depressive symptoms and coronary heart disease and their  

E-Print Network [OSTI]

Heart . Author manuscript Page /1 11 Effects of depressive symptoms and coronary heart disease separately in patients with coronary heart disease (CHD) and in populations healthy at study inception and CHD status. OBJECTIVE To examine effects of depressive symptoms and coronary heart disease

Paris-Sud XI, Université de

414

Cardiovascular Disease and Functional Foods: The Effect of Milk Derived Peptides on Hypertension  

E-Print Network [OSTI]

1 Cardiovascular Disease and Functional Foods: The Effect of Milk Derived Peptides on Hypertension and Hypertension Cardiovascular disease (CVD) encompasses many conditions including coronary heart disease, heart attack (myocardial infarction), stroke and hypertension. In 2003, CVD accounted for 16.7 million

Nottingham, University of

415

Congestive heart failure: treat the disease, not the symptom: return to normalcy/Part II--the experimental approach.  

E-Print Network [OSTI]

Title: Congestive heart failure: treat the disease not theTITLE: Congestive heart failure: treat the disease not theGD. Congestive heart failure: treat the disease, not the

Buckberg, Gerald D

2007-01-01T23:59:59.000Z

416

The Diet-Heart Hypothesis: a critical appraisal of the relationship between diet and coronary artery disease  

E-Print Network [OSTI]

for Prevention of Coronary Heart Disease. JAMA. 2002;288:M. Fish consumption and coronary heart disease mortality: aacid and risk of ischemic heart disease among women. Am J

Jurewitz, Daniel L

2007-01-01T23:59:59.000Z

417

New England Foot and Mouth Disease Tabletop Exercise  

SciTech Connect (OSTI)

The Multiscale Epidemiologic/Economic Simulation and Analysis (MESA) Decision Support System (DSS) is the product of investments that began in FY05 by the Department of Homeland Security (DHS) Science and Technology Directorate and continue today with joint funding by both DHS and the US Department of Agriculture (USDA). The DSS consists of a coupled epidemiologic/economic model, a standalone graphical user interface (GUI) that supports both model setup and post-analysis, and a Scenario Bank archive to store all content related to foreign animal disease (FAD) studies (Figure 1). The MESA epi model is an object-oriented, agent-based, stochastic, spatio-temporal simulator that parametrically models FAD outbreaks and response strategies from initial disease introduction to conclusion over local, regional, and national scales. Through its output database, the epi model couples to an economic model that calculates farm-level impacts from animal infections, responsive control strategies and loss of trade. The MESA architecture contains a variety of internal models that implement the major components of the epi simulation, including disease introduction, intra-herd spread, inter-herd spread (direct and indirect), detection, and various control strategies (movement restrictions, culling, vaccination) in a highly configurable and extensible fashion. MESA will produce both overall and daily summary statistics for the outbreak, epidemic curves, and costs associated with the outbreak. This information can be used to reconstruct and analyze the course of the outbreak. Geographical information produced by MESA can be used to produce maps and movies as visual aids to understand the distribution characteristics of a simulated outbreak.

Hullinger, P

2008-09-30T23:59:59.000Z

418

Loss of Hsp70 Exacerbates Pathogenesis But Not Levels of Fibrillar Aggregates in a Mouse Model of Huntington's Disease  

E-Print Network [OSTI]

Endogenous protein quality control machinery has long been suspected of influencing the onset and progression of neurodegenerative diseases characterized by accumulation of misfolded proteins. Huntington's disease (HD) ...

Lindquist, Susan

419

Development of Biomarkers for Chronic Beryllium Disease in Mice  

SciTech Connect (OSTI)

Beryllium is a strategic metal, indispensable for national defense programs in aerospace, telecommunications, electronics, and weaponry. Exposure to beryllium is an extensively documented occupational hazard that causes irreversible, debilitating granulomatous lung disease in as much as 3 - 5% of exposed workers. Mechanistic research on beryllium exposure-disease relationships has been severely limited by a general lack of a sufficient CBD animal model. We have now developed and tested an animal model which can be used for dissecting dose-response relationships and pathogenic mechanisms and for testing new diagnostic and treatment paradigms. We have created 3 strains of transgenic mice in which the human antigen-presenting moiety, HLA-DP, was inserted into the mouse genome. Each mouse strain contains HLA-DPB1 alleles that confer different magnitude of risk for chronic beryllium disease (CBD): HLA-DPB1*0401 (odds ratio = 0.2), HLA-DPB1*0201 (odds ratio = 15), HLA-DPB1*1701 (odds ratio = 240). Our preliminary work has demonstrated that the *1701 allele, as predicted by human studies, results in the greatest degree of sensitization in a mouse ear swelling test. We have also completed dose-response experiments examining beryllium-induced lung granulomas and identified susceptible and resistant inbred strains of mice (without the human transgenes) as well as quantitative trait loci that may contain gene(s) that modify the immune response to beryllium. In this grant application, we propose to use the transgenic and Â?normal inbred strains of mice to identify biomarkers for the progression of beryllium sensitization and CBD. To achieve this goal, we propose to compare the sensitivity and accuracy of the lymphocyte proliferation test (blood and bronchoalveolar lavage fluid) with the ELISPOT test in the three HLA-DP transgenic mice strains throughout a 6 month treatment with beryllium particles. Because of the availability of high-throughput proteomics, we will also identify changes in potential protein biomarkers in beryllium-treated mice. We will correlate these findings with the ability of the transgenic mice to develop a beryllium-specific adaptive immune response in blood and bronchoalveolar lavage (BAL) fluid. We will also determine whether beryllium-responsive CD4+ T cells in blood and BAL correlate with the onset of granuloma formation. Thus, we will provide the scientific community with biomarkers of sensitization and disease progression for CBD. These biomarkers will serve as critical tools for development of improved industrial hygiene and therapeutic interventions.

Gordon, Terry

2013-01-25T23:59:59.000Z

420

Storage and Diseases of the Sweet Potato in Texas.  

E-Print Network [OSTI]

readily apparent upon casual examination of the lot, and that any damage from the caum mentionecl can be removed by the ordinary process of paring witnout appreciable increase in waste over that which would oc-cur if the sweet potatoes were perfect. d...TEXAS A~~RICUL~~R~L EXPERIMENT STATION AGRICULTURAL AND MECHANICAL COLLEGE OF TEXAS W. B. BIZZELL, President BULLETIN TuO. 250 OCTOBER, 1919 EXPERIMENT STATION AND EXTENSION SERVICE COOPERATING STORAGE AND DISEASES OF THE SWEET POTATO...

Youngblood, B. (Bonney)

1919-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Harvard University Division of Continuing Education Harvard Extension School Harvard Summer School  

E-Print Network [OSTI]

Harvard University Division of Continuing Education Harvard Extension School · Harvard Summer to programs and services. To establish that an individual is covered under the ADA, the docu- mentation must-IV- TR), and The International Statistical Classification of Diseases and Related Health Problems, Tenth

422

Data:67840de4-3847-44f1-bfe8-ada958568a98 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office695810186 No revision has been approvedea02758d3 No revision has1574de6f No revision has5994d773cb4991f6895

423

Data:C1752766-b721-4248-ada7-9110d76daba5 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onb5-dcc1fcffd1f2bb71-d4159a938742 No revision has been

424

Data:08c71545-a256-4e92-ada2-ef5568659916 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentratingRenewable Solutions6ae4e73fc Nof7e0a4fbc9b253bedd No7-e86f2fd7b7e6ef5568659916 No

425

Data:A5596080-04dc-4fb9-9014-5364adae679b | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office695810186 Nod2db5b31cb44 Noddefe0-db39-48c0-ac98-7941b3451e3c No revision-8d52bc60b99f Noadae679b No revision has

426

Data:9262283e-7ada-4133-b64e-06d0038344f2 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office695810186 No revisione0a2d50bdf35248292f1 No revision has been040c1bfd8de42-a04a-30c00314504f

427

Data:806c5379-9829-4db9-ada1-864a88763c03 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office695810186 No revisione0a2d50bdf No revision has been approveddf99225215d Noa88763c03 No revision has been

428

Bead-based microfluidic immunoassay for diagnosis of Johne's disease  

SciTech Connect (OSTI)

Microfluidics technology offers a platform for development of point-of-care diagnostic devices for various infectious diseases. In this study, we examined whether serodiagnosis of Johne s disease (JD) can be conducted in a bead-based microfluidic assay system. Magnetic micro-beads were coated with antigens of the causative agent of JD, Mycobacterium avium subsp. paratuberculosis. The antigen-coated beads were incubated with serum samples of JD-positive or negative serum samples and then with a fluorescently-labeled secondary antibody (SAB). To confirm binding of serum antibodies to the antigen, the beads were subjected to flow cytometric analysis. Different conditions (dilutions of serum and SAB, types of SAB, and types of magnetic beads) were optimized for a great degree of differentiation between the JD-negative and JD-positive samples. Using the optimized conditions, we tested a well-classified set of 155 serum samples from JD negative and JD-positive cattle by using the bead-based flow cytometric assay. Of 105 JD-positive samples, 63 samples (60%) showed higher antibody binding levels than a cut-off value determined by using antibody binding levels of JD-negative samples. In contrast, only 43-49 JD-positive samples showed higher antibody binding levels than the cut-off value when the samples were tested by commercially-available immunoassays. Microfluidic assays were performed by magnetically immobilizing a number of beads within a microchannel of a glass microchip and detecting antibody on the collected beads by laser-induced fluorescence. Antigen-coated magnetic beads treated with bovine serum sample and fluorescently-labeled SAB were loaded into a microchannel to measure the fluorescence (reflecting level of antibody binding) on the beads in the microfluidic system. When the results of five bovine serum samples obtained with the system were compared to those obtained with the flow cytometer, a high level of correlation (linear regression, r2 = 0.994) was observed. In a further experiment, we magnetically immobilized antigen-coated beads in a microchannel, reacted the beads with serum and SAB in the channel, and detected antibody binding to the beads in the microfluidic system. A strong antibody binding in JD-positive serum was detected, whereas there was only negligible binding in negative control experiments. Our data suggest that the bead-based microfluidic system may form a basis for development of an on-site serodiagnosis of JD. Key Words: Mycobacterium avium ssp. paratuberculosis, Johne s disease, microfluidics, lab-on-a-chip.

Wadhwa, Ashutosh [University of Tennessee, Center for Wildlife Health, Department of Forestry; Foote, Robert [ORNL; Shaw, Robert W [ORNL; Eda, Shigetoshi [ORNL

2012-01-01T23:59:59.000Z

429

When you hear the term "heart disease," what's your first reaction? Like many women, you may think, "That's a  

E-Print Network [OSTI]

When you hear the term "heart disease," what's your first reaction? Like many women, you may think, "That's a man's disease." But here's The Heart Truth: Heart disease is the #1 killer of Latinas in the United States. Together with stroke, heart disease accounts for a third of all deaths among Latinas

Bandettini, Peter A.

430

Bisphosphonates and Bone diseases: past, present and future Bisphosphonates are stable analogues of the naturally-occuring inorganic  

E-Print Network [OSTI]

involving excessive bone resorption which include post-menopausal osteoporosis, Paget's disease of bone

Paris-Sud XI, Université de

431

Ulcerative colitis and steroid-responsive, diffuse interstitial lung disease  

SciTech Connect (OSTI)

The authors describe a patient with ulcerative colitis and extracolonic manifestations in whom diffuse interstitial pulmonary disease developed that was responsive to glucocorticoid therapy one year after total proctocolectomy. The patient presented in December 1983 with a subacute course marked by cough and progressive exertional dyspnea, abnormal chest examination results, and a chest roentgenogram that revealed diffuse interstitital and alveolar infiltrates. A transbronchial biopsy specimen revealed a polymorphic interstitial infiltrate, mild interstitial fibrosis without apparent intraluminal fibrosis, and no vasculitis, granulomas, or significant eosinophilic infiltration. Within one week of the initiation of daily high-dose steroid therapy, the patient's symptoms dramatically improved; chest roentgenogram and forced vital capacity (60%) improved at a slower rate. All three measures deteriorated when alternate-day prednisone therapy was started but once again improved until the patient was totally asymptomatic, chest roentgenograms were normal, and forced vital capacity was 80% of the predicted value 2 1/2 years later.

Balestra, D.J.; Balestra, S.T.; Wasson, J.H.

1988-07-01T23:59:59.000Z

432

Neurological Complications Following Endoluminal Repair of Thoracic Aortic Disease  

SciTech Connect (OSTI)

Open surgery for thoracic aortic disease is associated with significant morbidity and the reported rates for paraplegia and stroke are 3%-19% and 6%-11%, respectively. Spinal cord ischemia and stroke have also been reported following endoluminal repair. This study reviews the incidence of paraplegia and stroke in a series of 186 patients treated with thoracic stent grafts. From July 1997 to September 2006, 186 patients (125 men) underwent endoluminal repair of thoracic aortic pathology. Mean age was 71 years (range, 17-90 years). One hundred twenty-eight patients were treated electively and 58 patients had urgent procedures. Anesthesia was epidural in 131, general in 50, and local in 5 patients. Seven patients developed paraplegia (3.8%; two urgent and five elective). All occurred in-hospital apart from one associated with severe hypotension after a myocardial infarction at 3 weeks. Four of these recovered with cerebrospinal fluid (CSF) drainage. One patient with paraplegia died and two had permanent neurological deficit. The rate of permanent paraplegia and death was 1.6%. There were seven strokes (3.8%; four urgent and three elective). Three patients made a complete recovery, one had permanent expressive dysphasia, and three died. The rate of permanent stroke and death was 2.1%. Endoluminal treatment of thoracic aortic disease is an attractive alternative to open surgery; however, there is still a risk of paraplegia and stroke. Permanent neurological deficits and death occurred in 3.7% of the patients in this series. We conclude that prompt recognition of paraplegia and immediate insertion of a CSF drain can be an effective way of recovering spinal cord function and improving the prognosis.

Morales, J. P.; Taylor, P. R.; Bell, R. E.; Chan, Y. C. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Vascular Surgery (United Kingdom); Sabharwal, T. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Interventional Radiology (United Kingdom); Carrell, T. W. G. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Vascular Surgery (United Kingdom); Reidy, J. F. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Interventional Radiology (United Kingdom)], E-mail: John.Reidy@gstt.nhs.uk

2007-09-15T23:59:59.000Z

433

Dual-Energy CT Angiography in Peripheral Arterial Occlusive Disease  

SciTech Connect (OSTI)

We sought to study the accuracy of dual-energy computed tomographic angiography (DE-CTA) for the assessment of symptomatic peripheral arterial occlusive disease of the lower extremity by using the dual-energy bone removal technique compared with a commercially available conventional bone removal tool. Twenty patients underwent selective digital subtraction angiography and DE-CTA of the pelvis and lower extremities. CTA data were postprocessed with two different applications: conventional bone removal and dual-energy bone removal. All data were reconstructed and evaluated as 3D maximum-intensity projections. Time requirements for reconstruction were documented. Sensitivity, specificity, accuracy, and concordance of DE-CTA regarding degree of stenosis and vessel wall calcification were calculated. A total of 359 vascular segments were analyzed. Compared with digital subtraction angiography, sensitivity, specificity, and accuracy, respectively, of CTA was 97.2%, 94.1%, and 94.7% by the dual-energy bone removal technique. The conventional bone removal tool delivered a sensitivity of 77.1%, a specificity of 70.7%, and an accuracy of 72.0%. Best results for both postprocessing methods were achieved in the vascular segments of the upper leg. In severely calcified segments, sensitivity, specificity, and accuracy stayed above 90% by the dual-energy bone removal technique, whereas the conventional bone removal technique showed a substantial decrease of sensitivity, specificity, and accuracy. DE-CTA is a feasible and accurate diagnostic method in the assessment of symptomatic peripheral arterial occlusive disease. Results obtained by DE-CTA are superior to the conventional bone removal technique and less dependent on vessel wall calcifications.

Brockmann, Carolin, E-mail: carolin.brockmann@rad.ma.uni-heidelberg.de; Jochum, Susanne; Sadick, Maliha [University of Heidelberg, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim (Germany); Huck, Kurt [University of Heidelberg, I. Medical Clinic, Medical Faculty Mannheim (Germany); Ziegler, Peter [University of Heidelberg, Department of Surgery, Medical Faculty Mannheim (Germany); Fink, Christian; Schoenberg, Stefan O.; Diehl, Steffen J. [University of Heidelberg, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim (Germany)

2009-07-15T23:59:59.000Z

434

Characterization of the Meq oncoproteins of Marek's disease virus vaccine strain CVI988/Rispens  

E-Print Network [OSTI]

the condition in four adult male chickens in 1907 (Biggs, 1961; Marek, 1907). He described the disease as a "polyneuritis" or a ?neuritis interstitialis?, characterized by paralysis of the legs and wings. Grossly, the sacral plexuses and spinal cords were... leukosis virus (Biggs, 1961; Campbel, 1961; Elermann, 1922). Based on susceptibility, organs afected, and histopathogenesis, the disease can be distinguished from lymphoid leucosis and a new name, Marek?s disease, was proposed (Biggs, 1961). Later...

Ajithdoss, Dharani K.

2010-07-14T23:59:59.000Z

435

Isolation of the Left Innominate Artery in an Elderly Patient Without Congenital Heart Disease  

SciTech Connect (OSTI)

We report a rare anomaly consisting of a right aortic arch with an isolated left innominate artery in an elderly man without congenital heart disease.

Boren, Edwin L. Jr.; Matchett, W. Jean [Department of Radiology, Slot 556, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72210 (United States); Gagne, Paul J. [Department of Surgery, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72210 (United States); McFarland, David R. [Department of Radiology, Slot 556, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72210 (United States)

2000-01-15T23:59:59.000Z

436

Protein folding stress in neurodegenerative diseases: a glimpse into the ER .  

E-Print Network [OSTI]

??Several neurodegenerative diseases share common neuropathology, primarily featuring the presence in the brain of abnormal protein inclusions containing specific misfolded proteins. Recent evidence indicates that… (more)

Matus, Soledad

2011-01-01T23:59:59.000Z

437

E-Print Network 3.0 - aujeszky disease Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Summary: animals, the signs of disease are moderated and may just consist of a mild cough or mucopurulent nasal... studied in equine influenza. Notable exceptions outside the...

438

E-Print Network 3.0 - allergic eye diseases Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Measles, mumps, and rubella are serious diseases. Measles Measles virus causes rash, cough, runny nose... , eye irritation, and fever. It can lead to ear infection,...

439

E-Print Network 3.0 - artery disease results Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

? Peripheral Arterial Disease (PAD) is a serious condition that is associated with heart attack and stroke. PAD... results in a narrowing of the arteries that carry blood to...

440

E-Print Network 3.0 - artery disease risk Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

as well as powers of 10 to illustrate the magnitude of the research. Summary: factors for heart attack and coronary artery disease include: Bad genes (hereditary factors) ...

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

E-Print Network 3.0 - artery disease caused Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

? Peripheral Arterial Disease (PAD) is a serious condition that is associated with heart attack and stroke. PAD... results in a narrowing of the arteries that carry blood to...

442

E-Print Network 3.0 - addressing chronic disease Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Human Development Faculty Research Themes Summary: Cardiovascular and Circulatory Disease W. Larry Kenney Professor Kinesiology Email Address: W7K@PSU.EDU Research... ; the...

443

E-Print Network 3.0 - autosomal dominant diseases Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Alexander disease patients ... Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison...

444

E-Print Network 3.0 - apparent respiratory disease Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

San Joaquin Valley College CR BOISE STATE UNIVERSITY Associate of Science -Respiratory Care Course Equivalencies Summary: Current Topics in Respiratory Disease 3 RESPCARE 444...

445

Edge effects, not connectivity, determine the incidence and development of a foliar fungal plant disease.  

SciTech Connect (OSTI)

Using a model plant-pathogen system in a large-scale habitat corridor experiment, we found that corridors do not facilitate the movement of wind-dispersed plant pathogens, that connectivity of patches does not enhance levels of foliar fungal plant disease, and that edge effects are the key drivers of plant disease dynamics. Increased spread of infectious disease is often cited as a potential negative effect of habitat corridors used in conservation, but the impacts of corridors on pathogen movement have never been tested empirically. Using sweet corn (Zea mays) and southern corn leaf blight (Cochliobolus heterostrophus) as a model plant-pathogen system, we tested the impacts of connectivity and habitat fragmentation on pathogen movement and disease development at the Savannah River Site, South Carolina, USA. Over time, less edgy patches had higher proportions of diseased plants, and distance of host plants to habitat edges was the greatest determinant of disease development. Variation in average daytime temperatures provided a possible mechanism for these disease patterns. Our results show that worries over the potentially harmful effects of conservation corridors on disease dynamics are misplaced, and that, in a conservation context, many diseases can be better managed by mitigating edge effects.

Johnson, Brenda, L.; Haddad, Nick, M.

2011-08-01T23:59:59.000Z

446

Pediatric Intestinal Failure Associated Liver Disease is Revered with Six Months of Intravenous Fish Oil.  

E-Print Network [OSTI]

??Pediatric intestinal failure associated liver disease (IFALD) is associated with a high morbidity and mortality. Studies have suggested that when intravenous (IV) soybean oil (SO)… (more)

Calkins, Kara

2013-01-01T23:59:59.000Z

447

E-Print Network 3.0 - ameliorate coral disease Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Search Sample search results for: ameliorate coral disease Page: << < 1 2 3 4 5 > >> 1 Climate change impedes scleractinian corals as primary reef ecosystem engineers Summary:...

448

E-Print Network 3.0 - animal diseases host-pathogen Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

<< < 1 2 3 4 5 > >> 1 Vaccine and Infectious Disease Organization University of Saskatchewan Summary: .vido.org. Candidates are expected to have a strong background in...

449

E-Print Network 3.0 - asymptomatic gallstone disease Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of Biochemistry and Molecular Biology Collection: Biology and Medicine 13 AND THERAPY OF SICKLE CELL DISEASE Summary: S HPFH are asymptomatic and not anemic. Patients with SS or...

450

A Prioritized Research Agenda for Prevention and Control of Noncommunicable Diseases  

E-Print Network [OSTI]

haemoglobin disorders (sickle cell disease and thalassae-quality of care for sickle cell anaemia and thalassaemia * *carriers, such as sickle cell anaemia or thalassaemia); (ii)

WHO

2011-01-01T23:59:59.000Z

451

E-Print Network 3.0 - adult coeliac disease Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

FOR NEW PATIENTS Summary: , Colon, Prostate and Melanoma (Skin) Cancer; Thalassaemia or Sickle Cell, Coeliac Disease, Osteoporosis... YesNo Date(s) Details Diabetes Asthma Heart...

452

E-Print Network 3.0 - advanced hiv disease Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Chemistry ; Biology and Medicine 44 PRESS RELEA Oct. 28, 2009 Summary: Therapies for Sickle Cell Disease, HIVAIDS and Brain, Ovarian and Colorectal Cancers Three...

453

E-Print Network 3.0 - acute gallbladder disease Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Computer Technologies and Information Sciences ; Biology and Medicine 34 AND THERAPY OF SICKLE CELL DISEASE Summary: experiencing acute or severe exac- erbations of sickle cell...

454

Peripheral arterial disease and osteoporosis in older adults: the Rancho Bernardo Study  

E-Print Network [OSTI]

calcification and the risk of osteoporosis and fractures. Jarterial disease and osteoporosis in older adults: theassociation between PAD and osteoporosis and bone loss only

von Mühlen, D.; Allison, M.; Jassal, S. K.; Barrett-Connor, E.

2009-01-01T23:59:59.000Z

455

E-Print Network 3.0 - atherosclerotic vascular disease Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

provide objective quantitative data characterising Summary: . References: 1. Fact report: Heart, stroke and vascular diseases: AIHW Cat. No. CVD 27. Canberra: AIHW......

456

E-Print Network 3.0 - asbestos related disease Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Asbestos contamination in buildings is a significant environmental problem. Several diseases have... to the performance of emergency asbestos-related jobs. Licensed asbestos...

457

E-Print Network 3.0 - address diet-related diseases Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

pigments called... and fertilizers, that resist pests and diseases without the use of chemicals, and have improved nutritional... in India and Bangladesh alone. The global...

458

E-Print Network 3.0 - arsenic-induced proliferative diseases...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

results for: arsenic-induced proliferative diseases Page: << < 1 2 3 4 5 > >> 1 Environmental Health Perspectives VOLUME 108 | NUMBER 7 | July 2000 617 Arsenic-Induced Skin...

459

E-Print Network 3.0 - allergic lung disease Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

disease and promote... , teaches people with lung ... Source: National Center for Environmental Health- Publications and Products Collection: Environmental Sciences and Ecology 3...

460

E-Print Network 3.0 - artery disease drugs Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Drug Plan Benefit Guide Revised 101510 Summary: artery disease or congestive heart failure) are eligible for the Value-Based Prescription Drug Plan... (Coronary Artery...

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

E-Print Network 3.0 - aggravated creutzfeldt-jacob disease Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Proteins are the workhorses of the body, and the enigmatic process... secrets of protein folding that could lead to improved diagnosis and treatment of diseases Source: Daggett,...

462

A fuzzy logic controller for intestinal levodopa infusion in Parkinson’s disease.  

E-Print Network [OSTI]

?? The aim of this work is to evaluate the fuzzy system for different types of patients for levodopa infusion in Parkinson Disease based on… (more)

Jiang, Xiaowen

2010-01-01T23:59:59.000Z

463

E-Print Network 3.0 - animal disease management Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

certain measures for managing disease and improving livestock performance. Solution... farming in the UK was 3.5 billion. However, ... Source: Reading, University of - School...

464

E-Print Network 3.0 - affected vector-borne diseases Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

disease systems... between species diversity and ... Source: Cary Institute of Ecosystem Studies, Millbrook, New York; Holt, Robert D. - Department of Biology, University of...

465

Right Ventricular Assessment by Real-time Three-dimensional Echocardiography in Congenital Heart Disease.  

E-Print Network [OSTI]

??abstractThe remarkable improvement in survival of patients with congenital heart disease has led to a growing number of adult patients. In particular, patients with more… (more)

H.B. van der Zwaan (Heleen)

2011-01-01T23:59:59.000Z

466

Soil fungicides in relation to cotton seedling disease at various temperature levels  

E-Print Network [OSTI]

to obtain controlled spacing an4 4epth of seed ?hon ylanting, ~, , ~ 18 Xllnotration of seedling disease grades. Xi No evidence of diseases' energed 2 Sprouted' no e?L'donee of disease; no ssLergenoe. 5 Lesion less than three nao in length? 4i Lesion... of disease. 2, Emerged; lesion lees than three nn. long. ~Eaepgedj le&oh learn Qlall I%a ss, 10$$, gl aineb io the non proprietary nano ef sino ?thglene bi sdithiooarhanate. 4. Knerged~ sevorelF lesiono4, but not girdle4. 5? Energed~ dea4 or girdling...

Ranney, Carleton David

1955-01-01T23:59:59.000Z

467

E-Print Network 3.0 - acute gastrointestinal disease Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

erythematosus (SLE) 3. Scleroderma (Systemic sclerosis) 4. Crystal induced disease (Gout... : acute and chronic 3. Connective tissue 4. Joints (focus on synovium) 5....

468

E-Print Network 3.0 - acute bacterial diseases Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

erythematosus (SLE) 3. Scleroderma (Systemic sclerosis) 4. Crystal induced disease (Gout... : acute and chronic 3. Connective tissue 4. Joints (focus on synovium) 5....

469

E-Print Network 3.0 - active disease caused Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Princeton University Press. of foliar diseases caused by polycyclic, specialized, wind... K. A. Garrett and C. M. Cox. Applied biodiversity science: Managing emerging...

470

Development and application of mass spectrometry-based metabolomics methods for disease biomarker identification  

E-Print Network [OSTI]

Human societies face diverse health challenges including a rapidly aging population, rising incidence of metabolic disease, and increasing antibiotic resistance. These problems involve complex interactions between genes ...

Tong, Lily Victoria

2008-01-01T23:59:59.000Z

471

E-Print Network 3.0 - adult moyamoya disease Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

-intestinal, splenogonadal, and genital abnormalities. Neoplasms, nerve paralysis, Moya-Moya disease, and stroke are seen Source: Ober, Carole - Committee on Genetics &...

472

Holdover inoculum of Pseudomonas syringae pv. alisalensis from broccoli raab causes disease in subsequent plantings  

E-Print Network [OSTI]

about P. syringae pv. Plant Disease / August 2006 ABSTRACTsyringae pv. lachrymans in soil, plant debris, and thesyringae pv. tomato populations on field tomato plants.

Cintas, N A; Koike, S T; Bunch, R A; Bull, C T

2006-01-01T23:59:59.000Z

473

Associations between laryngeal and cough dysfunction in motor neuron disease with bulbar involvement.  

E-Print Network [OSTI]

??PURPOSE: Cough, a fundamental mechanism in airway protection, depends on true vocal fold (TVF) function and airflow. In individuals with motor neuron disease (MND), cough… (more)

Britton, Deanna J.

2013-01-01T23:59:59.000Z

474

E-Print Network 3.0 - anus diseases Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

University of Arizona Collection: Biology and Medicine ; Engineering 32 Local Scale Effects of Disease on Biodiversity Katherine F. Smith,1,2 Summary: Local Scale Effects...

475

Perceived Threat of a Heart Attack among Mexican Americans with Cardiovascular Disease Risk.  

E-Print Network [OSTI]

??Compared to the general population, Mexican Americans are at greater risk for cardiovascular disease (CVD) events, such as heart attack, due to the high prevalence… (more)

Florez, Elizabeth

2013-01-01T23:59:59.000Z

476

Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease  

E-Print Network [OSTI]

, and therein is regulated by injury. In the case of CNS demyelinating disease, K6 expression in CNS occurs in a tissue- specific fashion and are differentially regulated in response to CNS injury. While the human peripheral tissue. In a murine model of human CNS demyelinating inflammatory disease induced by Theiler's pi

Blaber, Michael

477

Health Alert: Treating acid reflux disease Posted: Feb 6, 2008 03:03 PM CST  

E-Print Network [OSTI]

Treating acid reflux disease Posted: Feb 6, 2008 03:03 PM CST Updated: Feb 6 Jiang Tang. Exciting news for patients like John who want to treat their nagging, reflux symptoms by Logan Smith 2/8/2008WIStv.com Columbia, SC: Health Alert: Treating acid reflux disease URL: http

Chiao, Jung-Chih

478

Modeling Disease Incidence Data with Spatial and Spatio-Temporal Dirichlet Process Mixtures  

E-Print Network [OSTI]

Modeling Disease Incidence Data with Spatial and Spatio-Temporal Dirichlet Process Mixtures approaches to analyze such data. We develop a hierarchical specification using spatial random effects modeled. Key words: Areal unit spatial data; Dirichlet process mixture models; Disease mapping; Dy- namic

Wolpert, Robert L

479

Lymphocystis Disease in Fish1 Roy P. E. Yanong, VMD2  

E-Print Network [OSTI]

FA181 Lymphocystis Disease in Fish1 Roy P. E. Yanong, VMD2 1. This document is FA181, one and marine fishes caused by infection with an iridovirus known as Lymphocystivirus or Lymphocystis disease does not cause significant mortalities, it does cause unsightly growths on fish that reduce

Watson, Craig A.

480

Asbestos-related diseases in automobile mechanics Jacques Ameille, MD1  

E-Print Network [OSTI]

1 Asbestos-related diseases in automobile mechanics Jacques Ameille, MD1 , Nicole Rosenberg, MD2-related diseases in automobile mechanics Corresponding author Jacques Ameille, MD, Unité de pathologie plaques, automobile mechanics, HRCT inserm-00671970,version1-20Feb2012 Author manuscript, published

Paris-Sud XI, Université de

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481

HOME GROUNDS & ANIMALS 2014 Home Fruit: Disease and Insects 3-1  

E-Print Network [OSTI]

HOME GROUNDS & ANIMALS 2014 Home Fruit: Disease and Insects 3-1 Disease and Insects Keith S. Yoder Pathologist, Alson H. Smith Jr. AREC Overview Growing fruits in the home orchard or garden can be an interesting and satisfying hobby, as well as a source of nutritious food for the home gardener. Tree fruits

Liskiewicz, Maciej

482

Patterns of health and disease have undergone dramatic transitions during human history, reflecting social and  

E-Print Network [OSTI]

of infectious disease and infant mortality decreased, lengthening life expectancy.At the same time,noninfectious chronic disease rose, accounting for a greater share of over- all mortality. Greater water and air dispersed into new habitats by phoresy (i.e.,one organism transporting another), flight, or wind, but human

Vermont, University of

483

Scientists Probe Immune System's Role in Brain Function and Neurological Disease  

E-Print Network [OSTI]

Scientists Probe Immune System's Role in Brain Function and Neurological Disease Bridget M. Kuehn E in normal brain development and in the healthy adult brain. Studies also suggest that per- turbations of these roles may under- lie some neurological diseases. Contrary to dogma that the blood- brain barrier

Boulanger, Lisa

484

Losses and Impact Distribution and Impacts of Annosus Root Disease in Forests of the  

E-Print Network [OSTI]

expanding root disease centers, in groups of various sizes, and as scattered individuals. Distribution impacts on resource and ecosystem values for a single site. Insofar as possible, the net effect in progressively expanding disease centers, in tree groups of various sizes, and in scattered individuals. One

Standiford, Richard B.

485

Speeding up disease extinction with a limited amount of vaccine M. Khasin,1  

E-Print Network [OSTI]

studied in stochastic population dynamics. Spontaneous extinction of species is important alsoSpeeding up disease extinction with a limited amount of vaccine M. Khasin,1 M. I. Dykman,1 and B stable; disease extinction happens at random and requires a large fluctuation, which can come from

Dykman, Mark

486

Home Monitoring of Oxygen Saturation and Symptoms for Sickle Cell Disease  

E-Print Network [OSTI]

Home Monitoring of Oxygen Saturation and Symptoms for Sickle Cell Disease Introduction and Aims There is evidence that the vaso-occlusive crises and other complications associated with sickle cell disease (SCD oxygen levels and the onset of sickle cell crises. A secondary objective of the study is to investigate

Oakley, Jeremy

487

National Center for Environmental Health Agency for Toxic Substances and Disease Registry  

E-Print Network [OSTI]

from exposure to environmental chemicals and selected other diseases that require advanced laboratoryNational Center for Environmental Health Agency for Toxic Substances and Disease Registry CS234527 environmental chemicals in blood and urine (5-year grants). · Newborn screening quality testing for more than

488

Real-Time Disease Surveillance Using Twitter Data: Demonstration on Flu and Cancer  

E-Print Network [OSTI]

, and text mining. The real-time analysis data is visually re- ported as U.S. disease activity map, timelinesReal-Time Disease Surveillance Using Twitter Data: Demonstration on Flu and Cancer Kathy Lee Ankit-effects, and so on. This makes publicly available social media data an invaluable resource for mining interesting

489

A medical game changer New device shows early promise for detecting heart disease  

E-Print Network [OSTI]

Fall 2012 A medical game changer New device shows early promise for detecting heart disease It as a functional test for people at high risk of developing heart disease, the leading cause of death in the United for enhancing auscultation (listening to heart sounds). Her husband, Robert Guion, was a convenient, good

Minnesota, University of

490

Coronary Heart Disease: Overview #1 Killer in the U.S.  

E-Print Network [OSTI]

#12;Coronary Heart Disease: Overview · #1 Killer in the U.S. · Accounts for more than one in five, the vessels that supply the heart · Disease process: coronary atherosclerosis (plagues in artery) involves flow, shortage of oxygen, pain that radiates across the chest and arms Myocardial infarction - heart

Meagher, Mary

491

Modeling Economic Resilience and Animal Disease Outbreaks in the Texas High Plains  

E-Print Network [OSTI]

. Enhanced surveillance is found to be a preferred mitigation strategy for U.S. consumers in the scenario of smaller feedlot disease introductions (e.g. Large Beef Grazing and Backyard) and for U.S. producers in the larger feedlot disease introduction...

Lin, Hen-I

2012-02-14T23:59:59.000Z

492

UPDATE ON THE POTATO PURPLE TOP DISEASE IN THE COLUMBIA BASIN J.E. MUNYANEZA1  

E-Print Network [OSTI]

UPDATE ON THE POTATO PURPLE TOP DISEASE IN THE COLUMBIA BASIN J.E. MUNYANEZA1 , J.M. CROSSLIN2 , A Washington State Potato Commission, Moses Lake, WA; 4 Oregon State University, Hermiston, OR; 5 Washington on the potato purple top disease in the Columbia Basin. In: Proceedings, 44th Annual Washington State Potato

Pappu, Hanu R.

493

3 Model Organisms in the Study of Development and Disease ETHAN BIER AND WILLIAM MCGINNIS  

E-Print Network [OSTI]

and invertebrates. This ancestor can be imagined as an advanced worm-like or primitive shrimp-like creature which for identifying and understanding genes that are altered in heritable human diseases and (2) the functions of many and inverte- brates. A systematic analysis of human disease gene homologs in Drosophila supports this view

McGinnis, William

494

Naam: mw. prof. dr. ir. Y.T. van der Schouw Leeropdracht Chronic Disease Epidemiology  

E-Print Network [OSTI]

differ between men and women, and how menopause and estrogens might be involved in this risk difference against chronic diseases of aging, such as cardiovascular disease, breast cancer, osteoporosis diabetics have been submitted. The third and most important area is the role of menopause and estrogens

Utrecht, Universiteit

495

"Red Sore Disease"in Game Fish1 Peggy Reed and Ruth Francis-Floyd2  

E-Print Network [OSTI]

frequently affected are game fish, particularly bluegill (bream), largemouth bass, and striped bass and itsVM85 "Red Sore Disease"in Game Fish1 Peggy Reed and Ruth Francis-Floyd2 1. This document is VM85 fish is generically referred to as "red sore disease." This problem usually occurs in the spring

Watson, Craig A.

496

The Factors of Chronic Kidney Disease: Diabetes, Hypertension, Smoking, Drinking, Betelnut Chewing  

E-Print Network [OSTI]

The Factors of Chronic Kidney Disease: Diabetes, Hypertension, Smoking, Drinking, Betelnut Chewing CKD 75 CKD Abstract The risk factors of Chronic Kidney Disease (CKD), including diabetes risk factors in a population-based cohort. Compared with single risk factors, diabetes (odds ratio 1

Chen, Chaur-Chin

497

Polycyclic aromatic hydrocarbons and fatal ischemic heart disease  

SciTech Connect (OSTI)

Several toxicologic and epidemiologic studies have produced evidence that occupational exposure to polycyclic aromatic hydrocarbons (PAH) is a risk factor for ischemic heart disease (IHD). However, a clear exposure-response relation has not been demonstrated. We studied a relation between exposure to PAH and mortality from IHD (418 cases) in a cohort of 12,367 male asphalt workers from Denmark, Finland, France, Germany, Israel, The Netherlands and Norway. Exposures to benzo(a)pyrene were assessed quantitatively using measurement-driven exposure models. Exposure to coal tar was assessed in a semiquantitative manner on the basis of information supplied by company representatives. We carried out sensitivity analyses to assess potential confounding by tobacco smoking. Both cumulative and average exposure indices for benzo(a)pyrene were positively associated with mortality from IHD. The highest relative risk for fatal IHD was observed for average benzo(a)pyrene exposures of 273 ng/m{sup 3} or higher, for which the relative risk was 1.64(95% confidence interval = 1.13-2.38). Similar results were obtained for coal tar exposure. Sensitivity analysis indicated that even in a realistic scenario of confounding by smoking, we would observe approximately 20% to 40% excess risk in IHD in the highest PAH-exposure categories. Our results lend support to the hypothesis that occupational PAH exposure causes fatal IHD and demonstrate a consistent exposure-response relation for this association.

Burstyn, I.; Kromhout, H.; Partanen, T.; Svane, O.; Langard, S.; Ahrens, W.; Kauppinen, T.; Stucker, I.; Shaham, J.; Heederik, D.; Ferro, G.; Heikkila, P.; Hooiveld, M.; Johansen, C.; Randem, B.G.; Boffetta, P. [International Agency for Research on Cancer, Lyon (France)

2005-11-01T23:59:59.000Z

498

Toxicological and pharmacological concerns on oxidative stress and related diseases  

SciTech Connect (OSTI)

Although reactive oxygen species (ROS) such as superoxide, hydrogen peroxide and hydroxyl radical are generated as the natural byproduct of normal oxygen metabolism, they can create oxidative damage via interaction with bio-molecules. The role of oxidative stress as a remarkable upstream part is frequently reported in the signaling cascade of inflammation as well as chemo attractant production. Even though hydrogen peroxide can control cell signaling and stimulate cell proliferation at low levels, in higher concentrations it can initiate apoptosis and in very high levels may create necrosis. So far, the role of ROS in cellular damage and death is well documented with implicating in a broad range of degenerative alterations e.g. carcinogenesis, aging and other oxidative stress related diseases (OSRDs). Reversely, it is cleared that antioxidants are potentially able to suppress (at least in part) the immune system and to enhance the normal cellular protective responses to tissue damage. In this review, we aimed to provide insights on diverse OSRDs, which are correlated with the concept of oxidative stress as well as its cellular effects that can be inhibited by antioxidants. Resveratrol, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, statins, nebivolol and carvedilol, pentaerythritol tetranitrate, mitochondria-targeted antioxidants, and plant-derived drugs (alone or combined) are the potential medicines that can be used to control OSRD.

Saeidnia, Soodabeh [Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411 (Iran, Islamic Republic of); College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon (Canada); Abdollahi, Mohammad, E-mail: Mohammad@TUMS.Ac.Ir [Department of Toxicology and Pharmacology, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 1417614411 (Iran, Islamic Republic of)

2013-12-15T23:59:59.000Z

499

Delays in Reducing Waterborne and Water-related Infectious Diseases in China under Climate Change  

SciTech Connect (OSTI)

Despite China’s rapid progress improving water, sanitation and hygiene (WSH) infrastructure and access, in 2011, 471 million people lacked access to improved sanitation, and 401 million people lacked access to household piped water. Infectious diseases are sensitive to changes in climate, particularly temperature, and WSH conditions. To explore possible impacts of climate change on these diseases in China in 2020 and 2030, we coupled estimates of the temperature sensitivity of diarrheal disease and three vector-borne diseases, temperature projections from global climate models using four emissions pathways, WSH-infrastructure development scenarios and projected demographic changes. By 2030, the projected impacts would delay China’s historically rapid progress toward reducing the burden of WSH-attributable infectious disease by 8-85 months. This developmental delay provides a key summary measure of the impact of climate change in China, and in other societies undergoing rapid social, economic, and environmental change.

Hodges, Maggie; Belle, Jessica; Carlton, Elizabeth; Liang, Song; Li, Huazhong; Luo, Wei; Freeman, Matthew C.; Liu, Yang; Gao, Yang; Hess, Jeremy; Remais, Justin V.

2014-12-01T23:59:59.000Z

500

Health Detectives: Uncovering the Mysteries of Disease (LBNL Science at the Theater)  

ScienceCinema (OSTI)

In this April 23, 2012 Science at the Theater event, Berkeley Lab scientists discuss how they uncover the mysteries of disease in unlikely places. Speakers and topics include: World-renowned cancer researcher Mina Bissell's pioneering research on the role of the cellular microenvironment in breast cancer has changed the conversation about the disease. How does DNA instability cause disease? To find out, Christie Canaria images neural networks to study disorders such as Huntington's disease. Fruit flies can tell us a lot about ourselves. Susan Celniker explores the fruit fly genome to learn how our genome works. DNA is not destiny. Gary Karpen explores how environmental factors shape genome function and disease through epigenetics.

Bissell, Mina; Canaria, Christie; Celnicker, Susan; Karpen, Gary

2014-05-06T23:59:59.000Z