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1

Drug Therapy: Alzheimer's Disease  

Science Journals Connector (OSTI)

...provide evidence supporting the concept that vitamin E, as well as vitamin C, has a role in delaying the onset of Alzheimer's disease.– Memantine. Memantine, an N-methyl-D-aspartate antagonist recently approved by the Food and Drug Administration (FDA) for the treatment of moderate-to-severe Alzheimer's... The prevalence of Alzheimer's disease is predicted to reach 13.2 million cases in the United States. This article considers current therapeutic approaches for Alzheimer's disease. Optimal management requires accurate diagnosis, which is increasingly based on an understanding of pathophysiology. Neuroprotective strategies, cholinesterase inhibitors, psychopharmacologic agents that may reduce behavioral disturbances, and newer agents such as memantine are discussed.

Cummings J.L.

2004-07-01T23:59:59.000Z

2

E-Print Network 3.0 - ada gene implies Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Machines for Detecting Alzheimer's Disease through... segmentation using different machine learning algo- rithms (1) hierarchical AdaBoost, (2) Support Vector... Machines (SVM)...

3

New Clues in Predicting Alzheimer's Disease  

ScienceCinema (OSTI)

Theres a new clue in the search to identify the harbingers of Alzheimers disease. More info: http://newscenter.lbl.gov/feature-stories/2008/12/16/predict-alzheimers-disease/

Jagust, William

2013-05-29T23:59:59.000Z

4

Inside Alzheimer's Disease  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

with illnesses ranging from cholera to vascular disease see the August 2011 and August 2014 issues of 1663, respectively. To that list, he and his Los Alamos colleague Ann...

5

alzheimer's disease: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and memory deterioration, a clinical hallmark of Alzheimer's disease that the primary factor in the pathogenesis of cognitive de ciencies in Alzheimer's disease is the...

6

Pharmacogenomics of Alzheimer’s Disease: Novel Therapeutic Strategies for Drug Development  

Science Journals Connector (OSTI)

Alzheimer’s disease (AD) is a major problem of health and disability, with a relevant economic impact on our society. Despite important advances in pathogenesis, diagnosis, and treatment, its primary causes st...

Ramón Cacabelos; Pablo Cacabelos…

2014-01-01T23:59:59.000Z

7

Donepezil and Memantine for Moderate-to-Severe Alzheimer's Disease  

Science Journals Connector (OSTI)

...when Alzheimer's disease becomes severe. Evidence of the efficacy of memantine has been shown primarily in patients with moderate or severe Alzheimer's disease. The findings of a study showing that combination therapy with memantine and a cholinesterase inhibitor was more effective than treatment with... Most studies evaluating cholinesterase inhibitors for the treatment of Alzheimer's disease have focused on patients with mild-to-moderate disease. Despite questions about the methods used in the trials1 and about the clinical significance of reported ...

Howard R.; McShane R.; Lindesay J.

2012-03-08T23:59:59.000Z

8

E-Print Network 3.0 - alzheimers disease brain Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

brain Search Powered by Explorit Topic List Advanced Search Sample search results for: alzheimers disease brain Page: << < 1 2 3 4 5 > >> 1 Understanding Alzheimer's Disease...

9

Understanding verbal fluency in healthy aging, Alzheimer’s disease, and Parkinson’s disease  

E-Print Network [OSTI]

McDowd, J., Hoffman, L., Rozek, E., Lyons, K., Pahwa, R., Burns, J. , & Kemper, S. (2011). Understanding verbal fluency in healthy aging, Alzheimer’s disease, and Parkinson’s disease. Neuropsychologia, 25, 210-225. DOI: 10.1037/a0021531.... Publisher’s official version: http://dx.doi.org/10.1037/a0021531. Open Access version: http://kuscholarworks.ku.edu/dspace/. 1 P le a se n o te t h a t th is is a n a u th o r- p ro d u ce d P D F o f a n a rt ic le a cc ep te d f o r p...

McDowd, Joan; Hoffman, Lesa; Rozek, Ellen Kathryn; Lyons, Kelly E.; Pahwa, Rajesh; Burns, Jeffrey M.; Kemper, Susan

2011-01-01T23:59:59.000Z

10

Journal of Alzheimer's Disease xx (20xx) xxx DOI 10.3233/JAD-132483  

E-Print Network [OSTI]

and Alzheimer's Disease as isoprostanes, neuroprostanes, acrolein, and hydrox- ynonenal (HNE), have also been

Mandal, Pravat K.

11

E-Print Network 3.0 - alzheimers disease caregivers Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

group for family caregivers and health... professionals The Alzheimer List is a free public service of the Alzheimer's Disease Research Center (ADRC... -mail based support...

12

Preventing Alzheimer's disease by means of natural selection  

Science Journals Connector (OSTI)

...Alzheimer's disease|natural selection|neuroenergetics...context of the amyloid cascade model. These features...solids, liquids and gases). Thermodynamic entropy...process, thus turning natural selection to our patients...matter-solid, liquid or gas. The quantity describes...

2015-01-01T23:59:59.000Z

13

Brain Iron as an Early Predictor of Alzheimer's Disease | Advanced...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

| 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed Brain Iron as an Early Predictor of Alzheimer's Disease JUNE 15, 2011 Bookmark and Share (A)...

14

Memantine in Moderate-to-Severe Alzheimer's Disease  

Science Journals Connector (OSTI)

...Memantine, an uncompetitive NMDA-receptor antagonist, could be of therapeutic value in Alzheimer's disease. A recent study in patients with advanced dementia (Alzheimer's disease and vascular dementia) suggested therapeutic benefits. Accordingly, we conducted a trial of the efficacy of memantine in... Overstimulation of the N-methyl-D-aspartate (NMDA) receptor by glutamate is implicated in neurodegenerative disorders. This 28-week study compared memantine, an NMDA-receptor antagonist, with placebo in persons with moderate-to-severe Alzheimer's disease. Among the patients who completed the study, memantine appeared to confer benefit in terms of activities of daily living and other measures; analysis of the last observation carried forward for the whole group supported this conclusion.

Reisberg B.; Doody R.; Stöffler A.

2003-04-03T23:59:59.000Z

15

E-Print Network 3.0 - alzheimers disease ad Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sample search results for: alzheimers disease ad Page: << < 1 2 3 4 5 > >> 1 4.2.5 NANOTECHNOLOGY TOWARDS CLINICAL DIAGNOSIS OF ALZHEIMER'S DISEASE D. Georganopoulu, L. Chang,...

16

Discontinuing Donepezil or Starting Memantine for Alzheimer's Disease  

Science Journals Connector (OSTI)

To the Editor: In the Donepezil and Memantine in Moderate to Severe Alzheimer's Disease (DOMINO) study, Howard and coauthors (March 8 issue) found that the magnitude of benefit, as assessed with the Standardized Mini–Mental State Examination (SMMSE) and the Bristol Activities of Daily Living Scale... To the Editor: In the Donepezil and Memantine in Moderate to Severe Alzheimer's Disease (DOMINO) study, Howard and coauthors (March 8 issue)1 found that the magnitude of benefit, as assessed with the Standardized Mini–Mental State Examination (SMMSE) and ...

2012-06-07T23:59:59.000Z

17

Discontinuing Donepezil or Starting Memantine for Alzheimer's Disease  

Science Journals Connector (OSTI)

...discontinue it, or switch to memantine, an N-methyl-D-aspartate–receptor antagonist that is specifically indicated for the treatment of moderate-to-severe Alzheimer's disease in both the United Kingdom and the United States. The NHS does not approve the addition of memantine to a cholinesterase inhibitor... Donepezil, the most frequently prescribed cholinesterase inhibitor for the treatment of Alzheimer's disease, was marketed in 1997 on the basis of the results of 3-month and 6-month clinical trials showing that patients had improvements in cognitive test ...

Schneider L.S.

2012-03-08T23:59:59.000Z

18

Memantine in Moderate-to-Severe Alzheimer's Disease  

Science Journals Connector (OSTI)

To the Editor: Reisberg et al. (April 3 issue) observed that the N-methyl-D-aspartate (NMDA) antagonist memantine appears to be helpful in patients with moderate-to-severe Alzheimer's disease. There is evidence that an increased plasma homocysteine level is an independent risk factor for the development... To the Editor: Reisberg et al. (April 3 issue)1 observed that the N-methyl-D-aspartate (NMDA) antagonist memantine2 appears to be helpful in patients with moderate-to-severe Alzheimer's disease. There is evidence that an increased plasma homocysteine ...

2003-08-07T23:59:59.000Z

19

Atlas-Based Hippocampus Segmentation In Alzheimer's Disease and Mild  

E-Print Network [OSTI]

Atlas-Based Hippocampus Segmentation In Alzheimer's Disease and Mild Cognitive Impairment Owen T of Chen to align the images to the Harvard atlas, MNI atlas, and randomly-selected, manually state, registration method, choice of atlas, and man- ual tracing protocol on the agreement between

20

Memory of myself: Autobiographical memory and identity in Alzheimer's disease  

E-Print Network [OSTI]

Memory of myself: Autobiographical memory and identity in Alzheimer's disease Donna Rose Addis autobiographical memory and identity. To test this we assessed the status of autobiographical memory and identity degree of autobiographical memory impairment was associated with changes in identity. Two tests

Addis, Donna Rose

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

E-Print Network 3.0 - alzheimers disease neuroimaging Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Disease... on NIA and ADEAR Websites...7 Alzheimer's Disease Education & Referral Center 2003 New CHID Resources... to examine how brains change as mild cognitive...

22

E-Print Network 3.0 - alzheimer disease human Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Disease... on NIA and ADEAR Websites...7 Alzheimer's Disease Education & Referral Center 2003 New CHID Resources... to examine how brains change as mild cognitive...

23

A nonsense mutation in PRNP associated with clinical Alzheimer's disease  

Science Journals Connector (OSTI)

Abstract Here, we describe a nonsense haplotype in PRNP associated with clinical Alzheimer's disease. The patient presented an early-onset of cognitive decline with memory loss as the primary cognitive problem. Whole-exome sequencing revealed a nonsense mutation in PRNP (NM_000311, c.C478T; p.Q160*; rs80356711) associated with homozygosity for the V allele at position 129 of the protein, further highlighting how very similar genotypes in PRNP result in strikingly different phenotypes.

Rita Guerreiro; José Brás; Aleksandra Wojtas; Rosa Rademakers; John Hardy; Neill Graff-Radford

2014-01-01T23:59:59.000Z

24

E-Print Network 3.0 - alzheimer type dementia Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Dementia Alzheimer's Disease 2010 Regional Alzheimer's Disease... Research Conference The Dementias: It's Not Always Alzheimer's Disease Alzheimer's Association Orange......

25

A new approach for improving diagnostic accuracy in Alzheimer’s disease and frontal lobe dementia utilising the intrinsic properties of the SPET dataset  

Science Journals Connector (OSTI)

Alzheimer’s disease (AD) and frontal lobe dementia (FLD) show characteristic patterns of regional cerebral blood flow (rCBF). However, these patterns may overlap with those observed in the aging brain in elder...

Marco Pagani; Vassili A. Kovalev…

2003-11-01T23:59:59.000Z

26

COGNITIVE NEUROLOGY AND ALZHEIMER'S DISEASE CENTER  

E-Print Network [OSTI]

the use of memantine (Namenda®) in those with a diagnosis of frontotemporal dementia (FTD). Memantine's disease suggests memantine may reduce damage to brain cells and therefore may also be effective in people with FTD. This study is designed to evaluate the safety and tolerability of memantine in FTD

Chisholm, Rex L.

27

E-Print Network 3.0 - alzheimer disease patterns Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Carnegie Mellon University Collection: Biology and Medicine 25 Modeling Intrinsically Disordered Proteins A number of neurodegenerative disorders such as Alzheimer's disease...

28

Alzheimer’s Disease: Pathophysiology and Applications of Magnetic Nanoparticles as MRI Theranostic Agents  

Science Journals Connector (OSTI)

Rademakers, R., Cruts, M., and Van Broeckhoven, C. ( 2003) Genetics of early-onset Alzheimer dementia Sci. ...

Houshang Amiri; Kolsoum Saeidi; Parvin Borhani; Arash Manafirad; Mahdi Ghavami; Valerio Zerbi

2013-09-11T23:59:59.000Z

29

Integrating discretization and association rule-based classification for Alzheimer's disease diagnosis  

Science Journals Connector (OSTI)

This paper shows a computer aided diagnosis (CAD) combining continuous attribute discretization and association rule mining for the early diagnosis of Alzheimer's disease (AD) based on emission computed tomography images. A mask is obtained from the ... Keywords: Alzheimer's disease, Association rules, Computed aided diagnosis, Discretization, Image histogram

R. Chaves; J. RamíRez; J. M. GóRriz

2013-04-01T23:59:59.000Z

30

Foundation for the Support of Research on Alzheimer's Disease and other Neurodegenerative Diseases Synapsis Foundation, Fabrikstrasse 50, CH-8031 Zrich  

E-Print Network [OSTI]

Foundation for the Support of Research on Alzheimer's Disease and other Neurodegenerative Diseases Synapsis Foundation, Fabrikstrasse 50, CH-8031 Zürich Tel. +41 (0)44 271 35 11, Fax +41 (0)44 271 35 12 Submission Deadline 31st August, 2011 SYNAPSIS FOUNDATION with its research programme "Alzheimer Research

Richner, Heinz

31

Innovative Alzheimer's disease clinical trial design in the coming age of biomarkers  

E-Print Network [OSTI]

Alzheimer's disease (AD) is a field with huge unmet need and only a few symptomatic treatments with limited efficacy have been made available to patients. With the testing of disease-modifying drugs in recent years, the ...

Hillerstrom, Hampus

2008-01-01T23:59:59.000Z

32

The Ethics of Early Evidence — Preparing for a Possible Breakthrough in Alzheimer's Disease  

Science Journals Connector (OSTI)

Being on the cusp of a potential medical breakthrough for a serious disease can pose substantial ethical challenges. One current example arises from a recent study demonstrating — in a single mouse model in one laboratory — that the drug bexarotene is effective in treating Alzheimer's disease (see... A recent study demonstrated, in a mouse model in one lab, that bexarotene (FDA-approved for use in non-Hodgkin's lymphoma) is effective against Alzheimer's disease. What should physicians do if patients with Alzheimer's disease begin seeking off-label prescriptions?

Lowenthal J.Hull S.C.Pearson S.D.

2012-08-09T23:59:59.000Z

33

Aluminum and silica intake in drinking water and the risk of Alzheimer's disease or cognitive decline: findings of the  

E-Print Network [OSTI]

Aluminum and silica intake in drinking water and the risk of Alzheimer's disease or cognitive,2 , Commenges Daniel1,2 , Helmer Catherine2,3 , Jean-François Dartigues2,3 . Abbreviations: Al, Aluminum; AD, Alzheimer's Disease; MMSE, Mini Mental State Examination; Si, Silica Running head: Aluminum, silica in water

Paris-Sud XI, Université de

34

Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients  

SciTech Connect (OSTI)

Mitochondrial DNA (mtDNA) variants associated with Alzheimer disease (AD) and Parkinson disease (PD) were sought by restriction endonuclease analysis in a cohort of 71 late-onset Caucasian patients. A tRNA[sup Gln] gene variant at nucleotide pair (np) 4336 that altered a moderately conserved nucleotide was present in 9/173 (5.2%) of the patients surveyed but in only 0.7% of the general Caucasian controls. One of these patients harbored an additional novel 12S rRNA 5-nucleotide insertion at np 956-965, while a second had a missense variant at np 3397 that converted a highly conserved methionine to a valine. This latter mutation was also found in an independent AD + PD patient, as was a heteroplasmic 16S rRNA variant at np 3196. Additional studies will be required to determine the significance, if any, of these mutations. 122 refs., 4 figs., 2 tabs.

Shoffner, J.M.; Brown, M.D.; Torroni, A.; Lott, M.T.; Cabell, M.F.; Mirra, S.S.; Yang, C.C.; Gearing, M.; Salvo, R. (Emory Univ. School of Medicine, Atlanta, GA (United States)); Beal, M.F. (Harvard Medical School, Boston, MA (United States)) (and others)

1993-07-01T23:59:59.000Z

35

BrainPrint in the Computer-Aided Diagnosis of Alzheimer's Disease  

E-Print Network [OSTI]

BrainPrint in the Computer-Aided Diagnosis of Alzheimer's Disease C. Wachinger1,2 , K cognitive impairment. We employ BrainPrint to obtain an extensive characterization of the shape of brain structures. BrainPrint captures shape information of an ensemble of cortical and subcortical structures

Golland, Polina

36

Cost-effectiveness of memantine in community-based Alzheimer’s disease patients: an adaptation in Spain  

Science Journals Connector (OSTI)

Several clinical trials have demonstrated the efficacy and safety of the NMDA antagonist memantine in moderately severe to severe Alzheimer’s ... compared to placebo. Long-term implications of memantine treatment...

Fernando Antonanzas; Benoit Rive…

2006-06-01T23:59:59.000Z

37

Micro-FTIR reveals co-localization of lipid oxidation and amyloid plaques in human Alzheimer disease brains  

Science Journals Connector (OSTI)

Micro-FTIR reveals co-localization of lipid oxidation and amyloid plaques in human Alzheimer disease brains ... However, it is known that plaques can be detected in the brains of some non-AD individuals. ...

Nuria Benseny-Cases; Oxana Klementieva; Marine Cotte; Isidre Ferrer; Josep Cladera

2014-11-21T23:59:59.000Z

38

Variable expression of presenilin 1 is not a major determinant of risk for late-onset Alzheimer's Disease  

Science Journals Connector (OSTI)

We have previously reported a significant association between early-onset Alzheimer's disease (EOAD) and an allele in the promoter of presenilin 1 (PSEN1) significantly decreasing PSEN1 expression in vitro. For ...

B. Dermaut; G. Roks; J. Theuns; R. Rademakers…

2001-11-01T23:59:59.000Z

39

Vitamin E and memantine in Alzheimer's disease: Clinical trial methods and baseline data  

Science Journals Connector (OSTI)

Background Alzheimer's disease (AD) has been associated with both oxidative stress and excessive glutamate activity. A clinical trial was designed to compare the effectiveness of (i) alpha-tocopherol, a vitamin E antioxidant; (ii) memantine (Namenda), an N-methyl-D-aspartate antagonist; (iii) their combination; and (iv) placebo in delaying clinical progression in AD. Methods The Veterans Affairs Cooperative Studies Program initiated a multicenter, randomized, double-blind, placebo-controlled trial in August 2007, with enrollment through March 2012 and follow-up continuing through September 2012. Participants with mild-to-moderate AD who were taking an acetylcholinesterase inhibitor were assigned randomly to 2000 IU/day of alpha-tocopherol, 20 mg/day memantine, 2000 IU/day alpha-tocopherol plus 20 mg/day memantine, or placebo. The primary outcome for the study is the Alzheimer's Disease Cooperative Study/Activities of Daily Living Inventory. Secondary outcome measures include the Mini-Mental State Examination; the Alzheimer's Disease Assessment Scale, cognitive portion; the Dependence Scale; the Neuropsychiatric Inventory; and the Caregiver Activity Survey. Patient follow-up ranged from 6 months to 4 years. Results A total of 613 participants were randomized. The majority of the patients were male (97%) and white (86%), with a mean age of 79 years. The mean Alzheimer's Disease Cooperative Study/Activities of Daily Living Inventory score at entry was 57 and the mean Mini-Mental State Examination score at entry was 21. Conclusion This large multicenter trial will address the unanswered question of the long-term safety and effectiveness of alpha-tocopherol, memantine, and their combination in patients with mild-to-moderate AD taking an acetylcholinesterase inhibitor. The results are expected in early 2013.

Maurice W. Dysken; Peter D. Guarino; Julia E. Vertrees; Sanjay Asthana; Mary Sano; Maria Llorente; Muralidhar Pallaki; Susan Love; Gerard D. Schellenberg; J. Riley McCarten; Julie Malphurs; Susana Prieto; Peijun Chen; David J. Loreck; Sara Carney; George Trapp; Rajbir S. Bakshi; Jacobo E. Mintzer; Judith L. Heidebrink; Ana Vidal-Cardona; Lillian M. Arroyo; Angel R. Cruz; Neil W. Kowall; Mohit P. Chopra; Suzanne Craft; Stephen Thielke; Carolyn L. Turvey; Catherine Woodman; Kimberly A. Monnell; Kimberly Gordon; Julie Tomaska; Govind Vatassery

2014-01-01T23:59:59.000Z

40

Correlates of Hippocampal Neuron Number in Alzheimer's Disease and Ischemic  

E-Print Network [OSTI]

White, MD,6 and Helena C. Chui, MD7 The cornu ammonis 1 region of the hippocampus (CA1) sector-vessel disease, and leukoariosis.1 The cornu ammonis 1 region of the hippocampus (CA1) sector of hippocampus

California at Davis, University of

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

The Role of HIV-1 Proteins in Alzheimer's Disease Pathology.  

E-Print Network [OSTI]

??Prevalence of HIV-associated cognitive impairment is rising, the worst form of which is HIV-associated dementia (HAD). The disease is fuiled by a chronic innate type… (more)

Giunta, Brian Nelson

2011-01-01T23:59:59.000Z

42

Variant of TREM2 Associated with the Risk of Alzheimer's Disease  

Science Journals Connector (OSTI)

...were primarily obtained through RAI 2.0 for Nursing Homes, which is a comprehensive and standardized instrument originally developed for residential facilities for the elderly, with additional information provided by the InterRAI Assessment for Home Care. We assessed cognitive function using the MDS Cognitive... This study shows that a variant of TREM2, which encodes a protein that suppresses inflammation, causes susceptibility to Alzheimer's disease. Although the variant is rare, its effect on the risk of disease is similar to that of the ?4 allele of apolipoprotein E.

Jonsson T.; Stefansson H.; Steinberg S.

2013-01-10T23:59:59.000Z

43

E-Print Network 3.0 - ada-deficient severe combined Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of genetic diseases such as hemo- philia, cystic fibrosis, adenosine deaminase (ADA... of personnel, and use of operating savings. The Op- tions Team evaluated several structural...

44

EA-0896; Research in Alzheimer's Disease Health Sciences Center - West Virginia University Environmental Assessment and (FONSI) Center For Nuclear Medicine Research In Alzheimer's Disease Health Sciences Center - West Virginia University  

Broader source: Energy.gov (indexed) [DOE]

6; Research in Alzheimer's Disease Health Sciences Center - West 6; Research in Alzheimer's Disease Health Sciences Center - West Virginia University Environmental Assessment and (FONSI) Center for Nuclear Medicine Research in Alzheimer's Disease Health Sciences Center - West Virginia University TABLE OF CONTENTS 1.0 DOCUMENT SUMMARY 1.1. Description 1.2 Alternatives 1.3 Affected Environment 1.4 Construction Impacts 1.5 Operating Impacts 2.0 PURPOSE AND NEED FOR AGENCY ACTION 3.0 DESCRIPTION OF ALTERNATIVES INCLUDING THE PROPOSED ACTION 3.1 Description of the Proposed Action 3.2.1 Construction Activities 3.2.2 Operation Activities 3.3 The No Action Alternative 3.4 Site Alternatives 4.0 THE AFFECTED ENVIRONMENT 5.0 ENVIRONMENTAL CONSEQUENCES OF THE PROPOSED ACTION AND ALTERNATIVES 5.1 Construction Impacts 5.1.1 Sensitive Resources

45

Plasma protein associations with hippocampal atrophy across the cognitive spectrum from normal aging to Alzheimer s disease  

E-Print Network [OSTI]

Plasma protein associations with hippocampal atrophy across the cognitive spectrum from normal aging to Alzheimer s disease Methods: We analyzed the imaging and plasma protein biomarker data from EDTA plasma samples were collected and analyzed with a 190 analyte multiplex immunoassay panel based

Thompson, Paul

46

In Vivo Characterization of CLR01, an Aggregation and Toxicity Inhibitor, with an Alzheimer's Disease Focus  

E-Print Network [OSTI]

NMDA receptors and memantine--searching for the connections.insults: focus on memantine. Behavioural Pharmacology 17:by the Alzheimer drug memantine. Journal of Biological

Attar, Aida

2013-01-01T23:59:59.000Z

47

Proteomic profiling of brain cortex tissues in a Tau transgenic mouse model of Alzheimer's disease  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer A transgenic mouse model expressing NSE-htau23 was used. Black-Right-Pointing-Pointer 2D-gel electrophoresis to analyze the cortex proteins of transgenic mice was used. Black-Right-Pointing-Pointer Differentially expressed spots in different stages of AD were identified. Black-Right-Pointing-Pointer GSTP1 and CAII were downregulated with the progression of AD. Black-Right-Pointing-Pointer SCRN1 and ATP6VE1 were up regulated and down regulated differentially. -- Abstract: Alzheimer's disease (AD) involves regionalized neuronal death, synaptic loss, and an accumulation of intracellular neurofibrillary tangles and extracellular senile plaques. Although there have been numerous studies on tau proteins and AD in various stages of neurodegenerative disease pathology, the relationship between tau and AD is not yet fully understood. A transgenic mouse model expressing neuron-specific enolase (NSE)-controlled human wild-type tau (NSE-htau23), which displays some of the typical Alzheimer-associated pathological features, was used to analyze the brain proteome associated with tau tangle deposition. Two-dimensional electrophoresis was performed to compare the cortex proteins of transgenic mice (6- and 12-month-old) with those of control mice. Differentially expressed spots in different stages of AD were identified with ESI-Q-TOF (electrospray ionization quadruple time-of-flight) mass spectrometry and liquid chromatography/tandem mass spectrometry. Among the identified proteins, glutathione S-transferase P 1 (GSTP1) and carbonic anhydrase II (CAII) were down-regulated with the progression of AD, and secerin-1 (SCRN1) and V-type proton ATPase subunit E 1 (ATP6VE1) were up-regulated only in the early stages, and down-regulated in the later stages of AD. The proteins, which were further confirmed by RT-PCR at the mRNA level and with western blotting at the protein level, are expected to be good candidates as drug targets for AD. The study of up- and down-regulation of proteins during the progression of AD helps to explain the mechanisms associated with neuronal degeneration in AD.

Chang, Seong-Hun; Jung, In-Soo; Han, Gi-Yeon; Kim, Nam-Hee; Kim, Hyun-Jung [School of Life Sciences and Biotechnology, Korea University, Seoul 136-701 (Korea, Republic of)] [School of Life Sciences and Biotechnology, Korea University, Seoul 136-701 (Korea, Republic of); Kim, Chan-Wha, E-mail: cwkim@korea.ac.kr [School of Life Sciences and Biotechnology, Korea University, Seoul 136-701 (Korea, Republic of)] [School of Life Sciences and Biotechnology, Korea University, Seoul 136-701 (Korea, Republic of)

2013-01-11T23:59:59.000Z

48

DEVELOPMENT OF AUTOMATED SOFTWARE PROGRAM FOR THE ANALYSIS OF ALZHEIMER'S DISEASE BETA-AMYLOID SCANS  

SciTech Connect (OSTI)

Study goal: A Phase 1 evaluation of the kinetics, clearance and cerebral distribution of one novel peripheral benzodiazepine receptors(PBR)positron emission tomography (PET) imaging agent, 18F-PBR-111 following intravenous administration in healthy volunteers and Alzheimer's disease (AD) patients. Short title: Evaluation of PET imaging with PBR-111 in HV and AD subjects Proof of Mechanism. Primary Objective: To evaluate the cerebral distribution of PBR-111 positron emission tomography (PET) for detection/exclusion of microglial activation in patients with Alzheimer's disease subjects compared to healthy volunteers. Secondary objectives: - To assess the dynamic uptake and washout of [18F]PBR-111, a potential imaging bio-marker for inflammatory changes in brain, using positron emission tomography in subjects with Alzheimer's disease (AD) and healthy volunteers (HV). - To perform blood metabolite characterization of [18F]PBR-111 in subjects with AD and HV to determine the nature of metabolites in assessment of [18F]-PBR-111 as a PET brain imaging agent. Name of radioactive drug substance: PBR-111 Dose(s): The applied PBR-111 radioactive dose will be up to 5.0 mCi, diluted in a maximum of 10 ml of saline. The radioligand will be administered as a slow intravenous bolus injection (i.e., 6 sec/ml) into a large vein (e.g., antecubital vein). Route of administration: Intravenous injection Duration of treatment: Single administration of a diagnostic agent Indication: PBR-111 positron emission tomography (PET) imaging has the potential to detect microglial activation. In the presence of PBR-111 uptake (representative of microglial activation), inflammation in the brain can be detected. Diagnosis and main criteria for inclusion: Study participants will be HVs and patients diagnosed with probable AD. HVs must be 18 years of age (at least four subjects 50 years of age) and have no evidence of cognitive impairment or other neurologic disease by medical history. The lack of cognitive impairment will also be based on a Clinical Dementia Rating (CDR) of 0. Patients with probable AD must be 50 years of age and must fulfill the National Institute of Neurological and Communicative Disorders and Stroke, Alzheimer's Disease and Related Disorders Association [NINCDS-ADRDA] criteria for probable AD. The CDR score must be 1.0 and 2.0 and have a modified Hachinski of 4. All HVs and all patients with probable AD must be able to comply with all study procedures. Study design: This is a Phase 1, open-label, single-center, non-randomized single dose study to assess the kinetics, clearance and cerebral distribution of PBR-111 PET imaging in detecting microglial activation in the brain in patients with probable AD compared to HVs. All aspects related to image acquisition, processing, and visual as well as quantitative evaluation will be developed, optimized, and validated (where required). Each subject will be required to visit the study center during the screening phase and on the PBR-111 PET imaging day (baseline). A telephone follow-up visit will be performed 7 days (± 3 days) after PBR-111 PET administration. At the screening visit, each subject (or caregiver in the case of AD subjects) will be asked to provide written informed consent or assent. During the screening phase (maximum duration of 60 days) subject medical, neurological, and surgical history, clinical assessments, and a neuro-psychiatric evaluation will be performed on all eligible subjects. Subjects will be allowed to leave the center after all evaluations have been completed. During this period an MRI of the brain will be performed during the screening period. If an MRI of the brain has been performed within six months of the imaging visit using the methods described in the protocol, and there has been no medically significant events in the interim, the previous MRI may be used. During the PBR-111 PET imaging day, all subjects will receive a single intravenous injection of PBR-111 and scanning will be performed over a 3.5 hour period. Each subject will have a telephone follow-up 7 da

Mariotti, Jack; Zubal, George

2013-12-18T23:59:59.000Z

49

Deterioration in donepezil-induced PR prolongation after a coadministration of memantine in a patient with Alzheimer's disease  

Science Journals Connector (OSTI)

Abstract The side effects and interaction of memantine and donepezil hydrochloride when used concomitantly are currently unknown. We encountered a case of a 77-year-old female with Alzheimer's disease in which the concomitant use of memantine exacerbated the prolonged electrocardiogram PR interval which appeared while donepezil hydrochloride was being orally administered. In terms of the cardiac circulation system side effects caused by donepezil hydrochloride and memantine, bradycardia has been reported. However, clinicians should be also aware of PR prolongation associated with the concomitant use of donepezil and memantine.

Hirofumi Igeta; Yutaro Suzuki; Takaharu Motegi; Aiko Sasaki; Yuichi Yokoyama; Toshiyuki Someya

2013-01-01T23:59:59.000Z

50

Label-Free Quantitative LC?MS Proteomics of Alzheimer&rsquo...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Label-Free Quantitative LC?MS Proteomics of Alzheimer’s Disease and Normally Aged Human Brains. Label-Free Quantitative LC?MS Proteomics of Alzheimer’s...

51

iCons, 2011 Alzheimers and Aluminum: Lesson Plan  

E-Print Network [OSTI]

© iCons, 2011 Alzheimers and Aluminum: Lesson Plan Handouts to explore mechanistic link between Alzheimer's and aluminum 5. Brief proposal expanding Points to Aluminum's Link With Alzheimer's Disease" from 1989. Provide handout

Auerbach, Scott M.

52

Colored figures Franke & Gaser (2012): Longitudinal changes in individual BrainAGE in healthy aging, mild cognitive impairment, and Alzheimer's disease  

E-Print Network [OSTI]

Colored figures Franke & Gaser (2012): Longitudinal changes in individual BrainAGE in healthy aging, mild cognitive impairment, and Alzheimer's disease Figure 1: Depiction of the BrainAGE concept. A: The model of healthy brain aging is trained with the chronological age and preprocessed structural MRI data

Gaser, Christian

53

Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-  

Science Journals Connector (OSTI)

In order to understand the molecular basis of action of the Alzheimer's disease passive immunotherapy candidate bapineuzumab, the Fab fragment of this antibody was crystallized in complexes with A peptides. The best crystals diffracted to a resolution of 2.0 ? (A residues 1-8) and 2.2 ? (A residues 1-28).

Crespi, G.A.N.

2014-02-20T23:59:59.000Z

54

ADA ES Inc | Open Energy Information  

Open Energy Info (EERE)

ADA ES Inc ADA ES Inc Jump to: navigation, search Name ADA-ES Inc Place Littleton, Colorado Zip 80120 Product Offers proprietary environmental technology and specialty chemicals to mitigate the environmental impact from electric power and industrial companies while reducing operating costs. Coordinates 39.697285°, -80.51095° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":39.697285,"lon":-80.51095,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

55

Supporting Ada in a distributed environment  

Science Journals Connector (OSTI)

This paper describes a set of tools which support a pre-partitioning approach to programming distributed systems in Ada. It also considers how these tools can be modified to support fault-tolerant applications.

A. D. Hutcheon; A. J. Wellings

1988-06-01T23:59:59.000Z

56

Using yeast to study neurodegenerative diseases : amyloid formation as a protective mechanism and a new Alzheimer's disease model  

E-Print Network [OSTI]

Numerous neurodegenerative diseases are pathologically characterized by idiosyncratic protein amyloid inclusions. Not surprisingly amyloid fibrils have long been proposed to be the toxic protein species in these neurodegenerative ...

Treusch, Sebastian

2011-01-01T23:59:59.000Z

57

Long-term associations between cholinesterase inhibitors and memantine use and health outcomes among patients with Alzheimer's disease  

Science Journals Connector (OSTI)

Objectives To examine in an observational study (1) relationships between cholinesterase inhibitors (ChEI) and memantine use, and functional and cognitive end points and mortality in patients with Alzheimer's disease (AD); (2) relationships between other patient characteristics and these clinical end points; and (3) whether effects of the predictors change across time. Methods The authors conducted a multicenter, natural history study that included three university-based AD centers in the United States. A total of 201 patients diagnosed with probable AD with modified Mini-Mental State Examination (MMSE) scores ? 30 at study entry were monitored annually for 6 years. Discrete-time hazard analyses were used to examine relationships between ChEI and memantine use during the previous 6 months reported at each assessment, and time to cognitive (MMSE score ? 10) and functional (Blessed Dementia Rating Scale score ? 10) end points and mortality. Analyses controlled for clinical characteristics, including baseline cognition, function, and comorbid conditions, and presence of extrapyramidal signs and psychiatric symptoms at each assessment interval. Demographic characteristics included baseline age, sex, education, and living arrangement at each assessment interval. Results ChEI use was associated with delayed time in reaching the functional end point and death. Memantine use was associated with delayed time to death. Different patient characteristics were associated with different clinical end points. Conclusions Results suggest long-term beneficial effects of ChEI and memantine use on patient outcomes. As for all observational cohort studies, observed relationships should not be interpreted as causal effects.

Carolyn W. Zhu; Elayne E. Livote; Nikolaos Scarmeas; Marilyn Albert; Jason Brandt; Deborah Blacker; Mary Sano; Yaakov Stern

2013-01-01T23:59:59.000Z

58

Multimodal EEG, MRI and PET Data Fusion for Alzheimer's Disease Diagnosis  

E-Print Network [OSTI]

in combining EEG, MRI and PET data using an ensemble of classifiers based decision fusion ap- proach using each individual data source. I. INTRODUCTION lhzeimer's disease is a neurodegenerative disorder, causing neuronal death that leads to cognitive function decline. Two misfolded proteins, -amyloid

Polikar, Robi

59

5-Hydroxymethylfurfural, an antioxidant agent from Alpinia oxyphylla Miq. improves cognitive impairment in A?1–42 mouse model of Alzheimer's disease  

Science Journals Connector (OSTI)

Abstract 5-Hydroxymethylfurfural (5-HMF) is a main effective compound of Alpinia oxyphylla Miq. ethanol extract, which showed memory improvement activity against Alzheimer's disease in previous study. In order to identify a potential therapeutic agent, the neuroprotective effects of 5-HMF on impairment of cognition and memory function induced by intracerebroventricular (ICV) injection of A?1–42 were investigated in vivo. The mice were treated with 5-HMF at dose of 15 ?g/kg and 150 ?g/kg (ICV) for five consecutive days after ICV-A?1–42. The results showed that 5-HMF significantly ameliorated learning and memory impairment evaluated by the locomotor activity, Y-maze test, and Morris water maze test. Furthermore, 5-HMF significantly inhibited the ?-secretase activity, decreased the content of A?1–42 and malondialdehyde (MDA), and increased the antioxidative enzyme activities including superoxide dismutase (SOD) and glutathione peroxidase (GPx). Results of hippocampus slices showed that neuronal were integrated and regularly arranged in the groups which were administered along with 5-HMF, indicating that 5-HMF could mitigate the degree of neuronal damage. The present study indicated that 5-HMF may serve as a potential therapeutic agent for the treatment of Alzheimer's disease.

Aijing Liu; Xu Zhao; Huan Li; Zhi Liu; Bing Liu; Xin Mao; Lin Guo; Kaishun Bi; Ying Jia

2014-01-01T23:59:59.000Z

60

Ada Yonath: Another Pioneering Woman in Science | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Ada Yonath: Another Pioneering Woman in Science Ada Yonath: Another Pioneering Woman in Science Ada Yonath: Another Pioneering Woman in Science March 25, 2011 - 4:51pm Addthis Nobel Prize winner in Chemistry, Ada Yonath | Credit nobelprize.org Nobel Prize winner in Chemistry, Ada Yonath | Credit nobelprize.org April Saylor April Saylor Former Digital Outreach Strategist, Office of Public Affairs In honor of Women's History Month, we've told you about a few great women in science and technology. Today we are highlighting another woman of present-day science, Ada Yonath, whose studies of the structure and function of the ribosome won her a Nobel Prize in Chemistry in 2009.{C}{C} According to the autobiography provided on NobelPrize.org, Yonath was born in Jerusalem in 1939 to a poor family that shared a small apartment with

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While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

MRI Study on Maple Syrup Urine Disease via the LONI Pipeline With the creation of large image datasets for quantitative disease classification and diagnosis, like the Alzheimer's Disease  

E-Print Network [OSTI]

MRI Study on Maple Syrup Urine Disease via the LONI Pipeline Overview: With the creation of large pipeline implementation. Given this need, software tools like STAMPS (http://www.ncbi.nlm.nih.gov/pubmed/19346025) and the LONI Pipeline (http://pipeline.loni.ucla.edu/) were developed. These tools integrate

Bjørnstad, Ottar Nordal

62

A novel approach to the identification and quantitative elemental analysis of amyloid deposits-Insights into the pathology of Alzheimer's disease  

SciTech Connect (OSTI)

There is considerable interest in the role of metals such as iron, copper, and zinc in amyloid plaque formation in Alzheimer's disease. However to convincingly establish their presence in plaques in vivo, a sensitive technique is required that is both quantitatively accurate and avoids isolation of plaques or staining/fixing brain tissue, since these processes introduce contaminants and redistribute elements within the tissue. Combining the three ion beam techniques of scanning transmission ion microscopy, Rutherford back scattering spectrometry and particle induced X-ray emission in conjunction with a high energy (MeV) proton microprobe we have imaged plaques in freeze-dried unstained brain sections from CRND-8 mice, and simultaneously quantified iron, copper, and zinc. Our results show increased metal concentrations within the amyloid plaques compared with the surrounding tissue: iron (85 ppm compared with 42 ppm), copper (16 ppm compared to 6 ppm), and zinc (87 ppm compared to 34 ppm).

Rajendran, Reshmi; Minqin, Ren [Centre for Ion Beam Applications, Department of Physics, Blk S 12, Faculty of Science, National University of Singapore, 2, Science Drive 3, Singapore 117542 (Singapore)] [Centre for Ion Beam Applications, Department of Physics, Blk S 12, Faculty of Science, National University of Singapore, 2, Science Drive 3, Singapore 117542 (Singapore); Ynsa, Maria Dolores [Centro de Micro-Analisis de Materiales (CMAM), Universidad Autonoma de Madrid, Campus de Cantoblanco, 28049 Madrid (Spain)] [Centro de Micro-Analisis de Materiales (CMAM), Universidad Autonoma de Madrid, Campus de Cantoblanco, 28049 Madrid (Spain); Casadesus, Gemma [Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106 (United States)] [Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106 (United States); Smith, Mark A.; Perry, George [Department of Pathology, Case Western Reserve University, Cleveland, OH 44106 (United States)] [Department of Pathology, Case Western Reserve University, Cleveland, OH 44106 (United States); Halliwell, Barry [Department of Biochemistry, National University of Singapore (Singapore)] [Department of Biochemistry, National University of Singapore (Singapore); Watt, Frank, E-mail: phywattf@nus.edu.sg [Centre for Ion Beam Applications, Department of Physics, Blk S 12, Faculty of Science, National University of Singapore, 2, Science Drive 3, Singapore 117542 (Singapore)] [Centre for Ion Beam Applications, Department of Physics, Blk S 12, Faculty of Science, National University of Singapore, 2, Science Drive 3, Singapore 117542 (Singapore)

2009-04-24T23:59:59.000Z

63

E-Print Network 3.0 - ada-europe international conference Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

for Artificial Intelligence A+ Summary: European Simulation Multiconference B ESS European Simulation Symposium B EuAda Ada-Europe International... Intelligence A+ AAMAS...

64

Alzheimer’s Amyloid-? Oligomers Rescue Cellular Prion Protein Induced Tau Reduction via the Fyn Pathway  

Science Journals Connector (OSTI)

(a) Dermaut, B., Croes, E. A., Rademakers, R., Van den Broeck, M., Cruts, M., Hofman, A., van Duijn, C. M., and Van Broeckhoven, C. ( 2003) PRNP Val129 homozygosity increases risk for early-onset Alzheimer’s disease Ann. ... Dermaut, Bart; Croes, Esther A.; Rademakers, Rosa; Van den Broeck, Marleen; Cruts, Marc; Hofman, Albert; van Duijn, Cornelia M.; Van Broeckhoven, Christine ...

Rong-Jie Chen; Wei-Wei Chang; Yu-Chun Lin; Pei-Lin Cheng; Yun-Ru Chen

2013-06-27T23:59:59.000Z

65

Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family  

Science Journals Connector (OSTI)

...Lovestone John C. Morris Leon Thal Michael Owen Julie Williams Alison Goate Andrew Grupe * Celera Diagnostics, Alameda, CA 94502...inheritance was assumed, was performed separately for each pair-wise combination of genotypes against disease status, showing significant...

Yonghong Li; Petra Nowotny; Peter Holmans; Scott Smemo; John S. K. Kauwe; Anthony L. Hinrichs; Kristina Tacey; Lisa Doil; Ryan van Luchene; Veronica Garcia; Charles Rowland; Steve Schrodi; Diane Leong; Goran Gogic; Joanne Chan; Anibal Cravchik; David Ross; Kit Lau; Shirley Kwok; Sheng-Yung Chang; Joe Catanese; John Sninsky; Thomas J. White; John Hardy; John Powell; Simon Lovestone; John C. Morris; Leon Thal; Michael Owen; Julie Williams; Alison Goate; Andrew Grupe

2004-01-01T23:59:59.000Z

66

City of Ada, Minnesota (Utility Company) | Open Energy Information  

Open Energy Info (EERE)

Ada, Minnesota (Utility Company) Ada, Minnesota (Utility Company) Jump to: navigation, search Name City of Ada Place Minnesota Utility Id 87 Utility Location Yes Ownership M NERC Location MRO NERC MRO Yes ISO MISO Yes Activity Distribution Yes References EIA Form EIA-861 Final Data File for 2010 - File1_a[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Utility Rate Schedules Grid-background.png Commercial Rates Commercial Demand Charge Industrial Rates Industrial Off Peak Commercial Commercial Off Peak Industrial Industrial Off Peak Rate Residential Residential Residential Rates Residential Water Heating Rates Residential Average Rates Residential: $0.0728/kWh Commercial: $0.0620/kWh Industrial: $0.0547/kWh

67

Micelle-Like Architecture of the Monomer Ensemble of Alzheimer's Amyloid-Peptide in Aqueous Solution and  

E-Print Network [OSTI]

, intrinsically disordered protein; CHC, central hydrophobic core; REMC, replica-exchange Monte Carlo; PMFMicelle-Like Architecture of the Monomer Ensemble of Alzheimer's Amyloid- Peptide in Aqueous. Case Keywords: Alzheimer's disease; Monte Carlo simulations; conformational equilibria; disorder

Caflisch, Amedeo

68

E-Print Network 3.0 - alzheimer type onset Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Alzheimer's disease (EOAD) and late-onset... ), with the parents and siblings of 131 LOAD patients (diagnosed at or ... Source: Columbia University, Taub Institute, Cognitive...

69

Neurological Disease  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Iron and neurodegenerative disease Iron and neurodegenerative disease A novel technique to study intracerebral iron oxide particles associated with Alzheimer's, Huntington's, and Parkinson's diseases has been developed. Researchers crafted a system of mirrors and lenses to tap one of the high-brightness x-ray sources at the Advanced Photon Source for the purpose of analyzing brain tissue. Mark Davidson (left in the photo), University of Florida, and Joanna Collingwood, Keele University in the United Kingdom (UK, who is supported by a UK Alzheimer's Society Research Fellowship and Dunhill Medical Trust), align a sample of Alzheimer's brain tissue at the microfocus facility, MR-CAT, beamline 10-ID. According to Davidson: "Unusual iron mineral nanoscale deposits have been associated with many neurodegenerative diseases, such as Alzheimer's,

70

Ada County, Idaho: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

Ada County, Idaho: Energy Resources Ada County, Idaho: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 43.478767°, -116.2420304° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":43.478767,"lon":-116.2420304,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

71

E-Print Network 3.0 - ada compiler system Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

part of any Ada compilation system. These are the runtime and tasking exec- utive, the library... , Information Systems ... Source: Schonberg, Edmond - Computer Science...

72

E-Print Network 3.0 - act ada accessibility Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of Brest, France... LISyCEA 3883 singhoff@univ-brest.fr Ada-Europe'08 tutorial, Venice - Page 179 ... Source: Brest, Universit de - Dpartement Informatique,...

73

STATEMENT OF CONSIDERATIONS REQUEST BY ADA ENVIRONMENTAL SOLUTIONS, FOR AN ADVANCE WAIVER OF  

Broader source: Energy.gov (indexed) [DOE]

ADA ENVIRONMENTAL SOLUTIONS, FOR AN ADVANCE WAIVER OF ADA ENVIRONMENTAL SOLUTIONS, FOR AN ADVANCE WAIVER OF DOMESTIC AND FOREIGN INVENTION RIGHTS IN SUBCONTRACTOR SHAW ENERGY & CHEMICALS, UNDER DOE COOPERATIVE AGREEMENT NO. DE- FE0004343, W(A)-2011-048, CH-1625 The Petitioner, ADA Environmental Solutions, LLC (ADAES) was awarded this cooperative agreement for the performance of work entitled , "Evaluation of Solid Sorbents as a Retrofit Technology for C0 2 Capture". ADAES is a small business, having the right to elect title to its inventions pursuant to the "Patent Rights-Small Business Fi rms and Nonprofit Organizations" clause of its contract. It is petition ing for rights to inventions of its large business subcontractor, Shaw Energy and Chemicals. A letter from Shaw agreeing to this disposition of invention rights is

74

Abstract--The prevalence of Alzheimer's disease (AD) is ris-ing alarmingly as the average age of our population increases.  

E-Print Network [OSTI]

be effectively used for early diagnosis of AD using an ensemble of classifiers based decision fusion approach. INTRODUCTION lzheimer's disease is a neurodegenerative disorder cha- racterized by progressive cognitive by accumulation of two misfolded proteins, -amyloid and hyperphosphorylated­au, which can only be detected

Polikar, Robi

75

E-Print Network 3.0 - ancianos con alzheimer Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

a Shelby C con w named valedictoria... By APRIL TOLER DAILY SUN THE VILLAGES -- H aving lost her mother to Alzheimer's disease and coping... with a sister who has been diagnosed,...

76

New Alzheimer's Treatments That May Ease the Mind  

Science Journals Connector (OSTI)

...Alzheimer's disease is a drug called memantine that works on a different neurotransmitter...and can overexcite neurons to death. Memantine is now in phase III clinical trials in...It showed that patients who received memantine maintained more mental abilities and...

Laura Helmuth

2002-08-23T23:59:59.000Z

77

Mechanistic insights into mode of action of potent natural antagonists of BACE-1 for checking Alzheimer’s plaque pathology  

SciTech Connect (OSTI)

Highlights: •Accumulation of A? plaques is one of the major pathology associated with Alzheimer’s disease. •Inhibition of ?-Secretase or BACE-1 offers a viable prospect to check the growth of these plaques. •A large virtual dataset of natural compounds was screened against BACE-1. •Top two hits were analyzed for thermodynamic and structural stability using MD simulations. •Their detailed binding mode of actions were elucidated. -- Abstract: Alzheimer’s is a neurodegenerative disorder resulting in memory loss and decline in cognitive abilities. Accumulation of extracellular beta amyloidal plaques is one of the major pathology associated with this disease. ?-Secretase or BACE-1 performs the initial and rate limiting step of amyloidic pathway in which 37–43 amino acid long peptides are generated which aggregate to form plaques. Inhibition of this enzyme offers a viable prospect to check the growth of these plaques. Numerous efforts have been made in recent years for the generation of BACE-1 inhibitors but many of them failed during the preclinical or clinical trials due to drug related or drug induced toxicity. In the present work, we have used computational methods to screen a large dataset of natural compounds to search for small molecules having BACE-1 inhibitory activity with low toxicity to normal cells. Molecular dynamics simulations were performed to analyze molecular interactions between the screened compounds and the active residues of the enzyme. Herein, we report two natural compounds of inhibitory nature active against ?-secretase enzyme of amyloidic pathway and are potent lead molecules against Alzheimer’s disease.

Dhanjal, Jaspreet Kaur [School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067 (India)] [School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067 (India); Goyal, Sukriti [Apaji Institute of Mathematics and Applied Computer Technology, Banasthali University, Tonk 304022, Rajasthan (India)] [Apaji Institute of Mathematics and Applied Computer Technology, Banasthali University, Tonk 304022, Rajasthan (India); Sharma, Sudhanshu [Department of Biotechnology, Delhi Technological University, New Delhi 110042 (India)] [Department of Biotechnology, Delhi Technological University, New Delhi 110042 (India); Hamid, Rabia [Department of Biochemistry, University of Kashmir, Srinagar 190006 (India)] [Department of Biochemistry, University of Kashmir, Srinagar 190006 (India); Grover, Abhinav, E-mail: abhinavgr@gmail.com [School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067 (India)] [School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067 (India)

2014-01-17T23:59:59.000Z

78

Hyperspectral imaging signatures detect amyloidopathy in Alzheimer’s mouse retina well before onset of cognitive decline  

Science Journals Connector (OSTI)

The technique was found useful for monitoring retinal and brain amyloidopathy in an ongoing preclinical anti-AD study, attesting to the technique’s sensitivity and specificity. ... Interestingly, the technique was found applicable not just to excised brain tissue, but also to isolated mouse retina. ... With the retina being heralded widely as a (diagnostic) extension of the CNS and retinal amyloidopathy occurring well before that in the brain, this development raises a possibility for the first direct retinal imaging diagnosis of early, asymptomatic Alzheimer’s disease. ...

Swati Sudhakar More; Robert Vince

2014-10-29T23:59:59.000Z

79

ADA/EEO Talking Notes Slide 1-Welcome to the New Employee Orientation session presented by the Office of Equal  

E-Print Network [OSTI]

ADA/EEO Talking Notes Slide 1-Welcome to the New Employee Orientation session presented by the Office of Equal Opportunity & Compliance or EOC. Slide2-This overview will cover EEO, ADA, Retaliation in the workplace. Please direct any of your questions regarding today's overview directly to EOC. Slide 3-The

Weston, Ken

80

How to Run Turing Machines on Encrypted Data Shafi Goldwasser Yael Kalai Raluca Ada Popa  

E-Print Network [OSTI]

How to Run Turing Machines on Encrypted Data Shafi Goldwasser Yael Kalai Raluca Ada Popa Vinod encryption, and garbling schemes work by modeling algorithms as circuits rather than as Turing machines cryptographic schemes for computing Turing machines on encrypted data that avoid the worst-case problem

Sabatini, David M.

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Longitudinal Medication Usage in Alzheimer Disease Patients  

E-Print Network [OSTI]

examined in detail patterns of cholinesterase inhibitors (ChEIs) and memantine use and explored characteristics on ChEIs/ memantine use over time. Independent variables included measures of function, cognition. During a 6-year study period, rate of ChEIs use decreased (80.6% to 73.0%) whereas memantine use

82

David Goodsell PRION ALZHEIMER'S  

E-Print Network [OSTI]

genes HSF activators are an exception - but is that good? (see recent Cell paper on HSF -- problem not just fertility but cancer) unique genes directly relevent to human disease #12;-synuclein: small lipid mining urban pollution drug abuse #12;Mul$ple' Disease'' Genes!" YPK9" Human'disease5related'gene' Gene

Sabatini, David M.

83

Proceedings of the 2011 ACM annual international conference on Special interest group on the ada programming language  

Science Journals Connector (OSTI)

Welcome to the 2011 Annual International Conference of the Association for Computing Machinery's (ACM's) Special Interest Group on the Ada Programming Language (SIGAda), being held in Denver, Colorado, in the heart of the western United States. We offer ...

Ricky E. Sward; Jeff Boleng; Michael Feldman; Dan Eilers; Jean-Pierre Rosen; Frank Singhoff; Julien DeLange; Mark Gardinier; Karl Nyberg

2011-11-01T23:59:59.000Z

84

Structural imaging biomarkers of Alzheimer's disease: predicting disease progression  

E-Print Network [OSTI]

of Statistics, Biostatistics & Medical Informatics, c Department of Radiology University of Wisconsin - Madison of Pediatric Otorhinolaryngology, 49, 197-206. 10. Vorperian, H. K., Kent, R. D., Lindstrom, M. J., Kalina, C

Boyer, Edmond

85

O/sup 6/-methylguanine-DNA methyltransferase in wild-type and ada mutants of Escherichia coli  

SciTech Connect (OSTI)

O/sup 6/-Methylguanine-DNA methyltransferase is induced in Escherichia coli during growth in low levels of N-methyl-N'-nitro-N-nitrosoguanidine. We have developed a sensitive assay for quantitating low levels of this activity with a synthetic DNA substrate containing /sup 3/H-labeled O/sup 6/-methylguanine as the only modified base. Although both wild-type and adaptation-deficient (ada) mutants of E. coli contained low but comparable numbers (from 13 to 60) of the enzyme molecules per cell, adaptation treatment caused a significant increase of the enzyme in the wild type but not in the ada mutants, suggesting that the ada mutation is in a regulatory locus and not in the structural gene for the methyltransferase.

Mitra, S.; Pal, B.C.; Foote, R.S.

1982-10-01T23:59:59.000Z

86

Single molecule profiling of tau gene expression in Alzheimer's Chris Conrad,*,1  

E-Print Network [OSTI]

Single molecule profiling of tau gene expression in Alzheimer's disease Chris Conrad,*,1 Jun Zhu and AD. Here, we applied a single-molecule-based technology, polymerase colony or polony is an emerging area of drug development, and a well-defined and quantitative assay for monitoring single

Church, George M.

87

AdaBoost for text detection Jung-Jin Lee, Pyoung-Hean Lee, Christof Koch and Alan Yuille  

E-Print Network [OSTI]

- cations, including robotics, vehicle license plate recognition system and text reading programsAdaBoost for text detection Jung-Jin Lee, Pyoung-Hean Lee, Christof Koch and Alan Yuille Department of Brain and Cognitive Engineering, Korea University, Seoul, 136-713, Korea Computation and Neural Systems

Yuille, Alan L.

88

Data:3822632d-04ff-4075-ada1-cd71f00dfd4e | Open Energy Information  

Open Energy Info (EERE)

04ff-4075-ada1-cd71f00dfd4e 04ff-4075-ada1-cd71f00dfd4e No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: South Central Public Pwr Dist Effective date: 2012/05/01 End date if known: Rate name: Area&Directional Lighting Service Rate N723 Sector: Lighting Description: Source or reference: Illinois State University Rate Binder #10 Source Parent: Comments Applicability Demand (kW) Minimum (kW): Maximum (kW): History (months): Energy (kWh) Minimum (kWh): Maximum (kWh): History (months): Service Voltage Minimum (V): Maximum (V): Character of Service Voltage Category: Phase Wiring: << Previous 1 2 3 Next >>

89

Data:05678b80-1064-4294-ada5-7dfc029a9989 | Open Energy Information  

Open Energy Info (EERE)

1064-4294-ada5-7dfc029a9989 1064-4294-ada5-7dfc029a9989 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Austin Energy Effective date: End date if known: Rate name: General Service - Non-Demand Commercial Sector: Commercial Description: * This rate is applicable to electric service required by any customer to whom no other specific rate applies and whose demand for power does not meet or exceed 20 kilowatts for any month within the most recent six summer billing months or as determined by the City of Austin. This rate is also applicable to athletic field accounts whose connected load is more than 85% attributable to lighting as verified by the City of Austin.

90

Data:67840de4-3847-44f1-bfe8-ada958568a98 | Open Energy Information  

Open Energy Info (EERE)

67840de4-3847-44f1-bfe8-ada958568a98 67840de4-3847-44f1-bfe8-ada958568a98 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: City of Elizabethton, Tennessee (Utility Company) Effective date: 2013/12/01 End date if known: Rate name: General Power - Schedule GSA 3 Sector: Commercial Description: Source or reference: http://www.eesonline.org/bill/current-rates/ Source Parent: Comments Applicability Demand (kW) Minimum (kW): Maximum (kW): History (months): Energy (kWh) Minimum (kWh): Maximum (kWh): History (months): Service Voltage Minimum (V): Maximum (V): Character of Service Voltage Category: Phase Wiring: << Previous

91

Data:22906034-05f1-4732-80ad-a02fc19b8535 | Open Energy Information  

Open Energy Info (EERE)

-05f1-4732-80ad-a02fc19b8535 -05f1-4732-80ad-a02fc19b8535 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Turlock Irrigation District Effective date: 2011/01/01 End date if known: Rate name: Schedule LC Street Lighting - Customer Owned-200 watt sodium vapor lamp Sector: Lighting Description: Applicability This schedule is applicable to lighting service for the illumination of public streets, alleys, highways and other publicly-dedicated outdoor places and is available to cities, counties, lighting districts or other public bodies where the District supplies electrical energy only, and the customer furnishes, installs, owns, operates and completely maintains lighting units including switching and all other associated equipment. Monthly Usage: 83kWh

92

Data:806c5379-9829-4db9-ada1-864a88763c03 | Open Energy Information  

Open Energy Info (EERE)

-9829-4db9-ada1-864a88763c03 -9829-4db9-ada1-864a88763c03 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: City of Smithville, Tennessee (Utility Company) Effective date: 2012/10/01 End date if known: Rate name: GSA-1 Sector: Commercial Description: Source or reference: ISU Archive Source Parent: Comments Applicability Demand (kW) Minimum (kW): Maximum (kW): History (months): Energy (kWh) Minimum (kWh): Maximum (kWh): History (months): Service Voltage Minimum (V): Maximum (V): Character of Service Voltage Category: Phase Wiring: << Previous 1 2 3 Next >> << Previous 1 2 3 Next >> Seasonal/Monthly Demand Charge Structures

93

Data:543ada29-6609-443c-908e-19b346647d34 | Open Energy Information  

Open Energy Info (EERE)

ada29-6609-443c-908e-19b346647d34 ada29-6609-443c-908e-19b346647d34 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Delta Electric Power Assn Effective date: 2008/07/01 End date if known: Rate name: 13 Street Lighting Mercury Vapor 175 Watt open Sector: Lighting Description: Available to governmental entities for lighting public streets, highways, alleys, parks, rest areas, playgrounds, and other public areas with controlled lighting provided by the Association. Service is from dusk to dawn. All street lighting equipment including lamps, fixtures, controls, and the necessary street lighting circuits, transformers, and additional guys and fittings will be owner, maintained, and operated by the Association. Lamp replacement will be by the Association.

94

Data:A74d3f9d-3ada-4581-befb-259264616b5c | Open Energy Information  

Open Energy Info (EERE)

d3f9d-3ada-4581-befb-259264616b5c d3f9d-3ada-4581-befb-259264616b5c No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: City of Anaheim Effective date: 2012/09/12 End date if known: Rate name: Residential- Schedule D Sector: Residential Description: Applicable to domestic service including lighting, heating, cooking and power or combination thereof in a single-family accommodation. Source or reference: http://www.anaheim.net/utilities/ElectricRules/SCHD-D.pdf Source Parent: Comments Applicability Demand (kW) Minimum (kW): Maximum (kW): History (months): Energy (kWh) Minimum (kWh): Maximum (kWh): History (months):

95

Data:08c71545-a256-4e92-ada2-ef5568659916 | Open Energy Information  

Open Energy Info (EERE)

545-a256-4e92-ada2-ef5568659916 545-a256-4e92-ada2-ef5568659916 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Otter Tail Power Co Effective date: 2011/10/01 End date if known: Rate name: Farm Service Single Phase Sector: Commercial Description: RULES AND REGULATIONS: Terms and conditions of this electric rate schedule and the General Rules and Regulations govern use of this service. APPLICATION OF SCHEDULE: This schedule is applicable to general Farm and home use. The Customer may elect to have the following service offerings in the farm home (for residential uses); Residential Service (Section 9.01) or Residential Demand Control Service Schedule (Section 9.02) if all the requirements specified for the schedules are satisfied.

96

Long-term associations between cholinesterase inhibitors and memantine use and health outcomes among patients with Alzheimer's  

E-Print Network [OSTI]

Long-term associations between cholinesterase inhibitors and memantine use and health outcomesEI) and memantine use, and functional and cognitive end points and mortality in patients with Alzheimer's disease to examine relationships between ChEI and memantine use during the previous 6 months reported at each

97

PROTEIN INTERACTIONS AND DISEASE MARICEL KANN  

E-Print Network [OSTI]

and illnesses, including AIDS, cancer, and Alzheimer's disease. The goal of this session is to discuss interaction data to identify active pathways re- lated to HIV pathogenesis. A functional analysis for successful inference of protein interactions. Chen et al. developed a framework to mine disease

Radivojac, Predrag

98

Regional variability of imaging biomarkers in autosomal dominant Alzheimer’s disease  

Science Journals Connector (OSTI)

...Bateman Nigel J. Cairns Anne M. Fagan Alison Goate Daniel S. Marcus Paul S. Aisen...Information (Figs. S6–S8). For vertex-wise group analyses, uncorrected SUVR images...all cross-sectional ROI and vertex-wise measures was performed using the nlme package...

Tammie L. S. Benzinger; Tyler Blazey; Clifford R. Jack; Jr.; Robert A. Koeppe; Yi Su; Chengjie Xiong; Marcus E. Raichle; Abraham Z. Snyder; Beau M. Ances; Randall J. Bateman; Nigel J. Cairns; Anne M. Fagan; Alison Goate; Daniel S. Marcus; Paul S. Aisen; Jon J. Christensen; Lindsay Ercole; Russ C. Hornbeck; Angela M. Farrar; Patricia Aldea; Mateusz S. Jasielec; Christopher J. Owen; Xianyun Xie; Richard Mayeux; Adam Brickman; Eric McDade; William Klunk; Chester A. Mathis; John Ringman; Paul M. Thompson; Bernardino Ghetti; Andrew J. Saykin; Reisa A. Sperling; Keith A. Johnson; Stephen Salloway; Stephen Correia; Peter R. Schofield; Colin L. Masters; Christopher Rowe; Victor L. Villemagne; Ralph Martins; Sebastien Ourselin; Martin N. Rossor; Nick C. Fox; David M. Cash; Michael W. Weiner; David M. Holtzman; Virginia D. Buckles; Krista Moulder; John C. Morris

2013-01-01T23:59:59.000Z

99

Functional Genomics of Brain Aging and Alzheimer’s Disease: Focus on Selective Neuronal Vulnerability  

E-Print Network [OSTI]

between two tis- sues (Spearman rank correlation, r, and significance P val- ues), the frontal pole of the Lu et al. study and one of the tissues studied by Khaitovich et al. The investigators de- scribed a highly significant correlation between... the frontal pole in the Lu et al. study and each of the four regions of the cerebral cortex in the Khaitovich et al. study (anterior cingu- late cortex, Broca’s area, prefrontal cortex, and primary vis- ual cortex, r>0.8 and p<0.02), but a lack...

Wang, Xinkun; Michaelis, Mary L.; Michaelis, Elias K.

2010-10-21T23:59:59.000Z

100

Memantine in Moderately-Severe-to-Severe Alzheimer’s Disease  

Science Journals Connector (OSTI)

Background:...Postmarketing surveillance studies (PMS) are an important tool for evaluating a drug’s effectiveness and safety in clinical practice. To our knowledge, no PMS on memantine monothera...

Dr Francesca Clerici; Nicola Vanacore; Antonietta Elia…

2009-04-01T23:59:59.000Z

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Memantine and Cholinesterase Inhibitors: Complementary Mechanisms in the Treatment of Alzheimer’s Disease  

Science Journals Connector (OSTI)

This review describes the preclinical mechanisms that may underlie the increased therapeutic benefit of combination therapy—with the N-methyl-d-aspartate receptor antagonist, memantine, and an acetylcholinesteras...

Chris G. Parsons; Wojciech Danysz; Andrzej Dekundy; Irena Pulte

2013-10-01T23:59:59.000Z

102

Free membership Agriculture Alzheimer Antibiotics  

E-Print Network [OSTI]

Davis News Service, Tel:(530) 752-6101 Source: UC Davis Views: 13 views Report this Article Comments (0 Climate DNA Diabetes Diseases Drugs Earth Science Ecology Energy Engineering Environment Genes Genetics by a team of researchers at the University of California, Davis. The recordings provide new information

Kowalczykowski, Stephen C.

103

A State-Wide Research Network for Alzheimer's Disease  

SciTech Connect (OSTI)

The Specific Aim of the proposal was to develop an administrative structure that will facilitate the development of AD research across the state of SC by providing key services such as (but not limited to) seeking funding research opportunities, financial tracking, regulatory management, central recruitment, training for investigators and coordinators, data collection, data storing, and data processing to researchers across the state.

Mintzer, Jacobo E.; Bachman, D. L.; Stuckey, M.; Ebeling, M.; Wagner, M. T.; Evans, W. J.; Hirth, V.; Walker, A.; Joglekar, R.; Faison, W.

2014-03-13T23:59:59.000Z

104

Alzheimer's disease: a disorder of cortical cholinergic innervation  

Science Journals Connector (OSTI)

...program for the elec-tric power industry. EPRI selects and...systems-Tennessee Valley Authority and the Bonneville Power Administration. About 150 non-member utilities...Tennessee Valley Au-thority and Bonneville Power Adminis-tration, no...

JT Coyle; DL Price; MR DeLong

1983-03-11T23:59:59.000Z

105

Educational attainment and rate of cognitive decline in Alzheimer's disease  

E-Print Network [OSTI]

with older adults (B?ckman, Small, Wahlin, & Larsson, 1999; Fillenbaum, Hughes, Heyman, George, & Blazer, 1988; Folstein, Folstein, & McHugh, 1975; Scherr et al., 1988; Snowdon, Ostwald, Kane, & Keenan, 1989). In a qualitative review of the literature...

Hemmy, Laura Sue

2009-05-15T23:59:59.000Z

106

100 Years and Counting: Prospects for Defeating Alzheimer's Disease  

Science Journals Connector (OSTI)

...acetylcholine after its release at synapses. Memantine prevents overstimulation of the N-methyl...both cholinesterase inhibitors and memantine have shown beneficial but modest effects...has been questioned (10). Because memantine is beneficial in patients already taking...

Erik D. Roberson; Lennart Mucke

2006-11-03T23:59:59.000Z

107

Utilization of Antihypertensives, Antidepressants, Antipsychotics, and Hormones in Alzheimer Disease  

E-Print Network [OSTI]

characteristics included use of cholinesterase inhibitors and/or memantine, function, cognition, living situation significant. Antihypertensive use was associated with poorer functioning, concurrent use of memantine inhibitors and memantine. Hormone use was associated with being female and younger age. Findings suggest

108

Analysis of Senate Bill 415: Prescription Drugs for Alzheimer's Disease  

E-Print Network [OSTI]

R, Sherriff F. (2004). Memantine for dementia. CochraneMcShane et al. , 2004 Memantine NPI: WMD ?3.5 to ?3.6Katona C. (2004). The place of memantine in the treatment of

California Health Benefits Review Program (CHBRP)

2005-01-01T23:59:59.000Z

109

Combining Multichannel ERP Data for Early Diagnosis of Alzheimer's Disease  

E-Print Network [OSTI]

. A neurodegenerative disorder, AD is caused by neuronal death due two misfolded proteins, -amyloid and describe an ensemble of classifiers based ap- proach that combines decision and data fusion techniques

Polikar, Robi

110

Cognitive Reserve and Alzheimer Disease Yaakov Stern, PhD  

E-Print Network [OSTI]

that individual differences in how tasks are processed provide differential reserve against brain pathology or age-related changes. This may take 2 forms. In neural reserve, preexisting brain networks that are more efficient of reserve against brain damage stems from the repeated observation that there does not seem to be a direct

111

A Graph Theoretic Mathematical Model for Alzheimer's disease  

E-Print Network [OSTI]

by microglia, a cytokine that inhibits the secretion of IL1 and TNA. Dysregulation of lipid metabolism lipids that is dysregulated, though its exact mechanism in the AD process is not well

Baras, John S.

112

Translating cell biology into therapeutic advances in Alzheimer's disease  

Science Journals Connector (OSTI)

... the past two decades have sought to provide information about one or more of three interrelated questions. First, what are the causes of the disorder? Second, regardless of cause ... plaques and tangles were end-stage lesions that apparently represented the tombstones of the pathogenic process, such knowledge would provide little useful information about aetiology and early pathogenesis. It has ...

Dennis J. Selkoe

1999-06-24T23:59:59.000Z

113

Data:5293078a-2a3d-4e05-a383-ada08086ae33 | Open Energy Information  

Open Energy Info (EERE)

2a3d-4e05-a383-ada08086ae33 2a3d-4e05-a383-ada08086ae33 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: City of Emerson, Nebraska (Utility Company) Effective date: 2013/01/01 End date if known: Rate name: Irrigation-Time of Use Sector: Commercial Description: Available for service to irrigation pumps, subject to District's established rules and regulations. Rural Residential $ 13.70 per month Town Residential $ 12.25 per month Farm Single Ph. $ 13.70 per month Rural 3 Phase $ 23.85 per month Gen. Service Sing. Ph. $ 15.60 per month Gen. Service 3 Phase $ 21.20 per month Source or reference: http://www.nnppd.com/billing/rates/files/SCHEDULE_I-T-O-U_2012.pdf

114

Multivariate Protein Signatures of Pre-Clinical Alzheimer's Disease in the Alzheimer's Disease Neuroimaging Initiative (ADNI) Plasma Proteome Dataset  

E-Print Network [OSTI]

these samples. Following dataset pruning, 17 analytes passedwere incorporated back into the dataset for assessment ofADNI) Plasma Proteome Dataset Daniel Johnstone 1,2 ,

Johnstone, Daniel; Milward, Elizabeth A.; Berretta, Regina; Moscato, Pablo

2012-01-01T23:59:59.000Z

115

Data:49499f69-1a41-406e-8894-7e38ada87b2d | Open Energy Information  

Open Energy Info (EERE)

1a41-406e-8894-7e38ada87b2d 1a41-406e-8894-7e38ada87b2d No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Imperial Irrigation District Effective date: 1994/11/01 End date if known: Rate name: SCHEDULE SL-3 STREET AND HIGHWAY LIGHTING SERVICE-MERCURY VAPOR 100W Sector: Lighting Description: APPLICABILITY Applicable to service to street and highway lighting installations where the customer owns the equipment and the District furnishes energy at one or more central points and maintains the equipment in accordance with Special Conditions set forth herein. Monthly Usage: 45kWh Source or reference: http://www.iid.com/Modules/ShowDocument.aspx?documentid=2579

116

Data:Fe881325-eb71-45ad-a4cd-f2fe3c28f436 | Open Energy Information  

Open Energy Info (EERE)

325-eb71-45ad-a4cd-f2fe3c28f436 325-eb71-45ad-a4cd-f2fe3c28f436 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Orange County Rural E M C Effective date: 2012/01/01 End date if known: Rate name: Rate 101- 2012 Rate Schedule for Standard Service Sector: Residential Description: Wholesale Power Cost Tracker changes quarterly. Available to any member of the REMC located on its lines for standard service whose installed capacity does not exceed 50KVA. Source or reference: http://www.orangecountyremc.org/electricrates.html Source Parent: Comments Applicability Demand (kW) Minimum (kW): Maximum (kW):

117

Data:E96dc2d1-abdc-4cde-bd0d-b1ada38fdae7 | Open Energy Information  

Open Energy Info (EERE)

d1-abdc-4cde-bd0d-b1ada38fdae7 d1-abdc-4cde-bd0d-b1ada38fdae7 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Austin Energy Effective date: 2012/10/01 End date if known: Rate name: City of Austin - Owned Outdoor Lighting - 400 W Mercury Vapor Sector: Description: Power Supply Adjustment fee - plus an adjustment for variable costs, calculated under the Power Supply Adjustment rate schedule , multiplied by the billable kWh. Source or reference: www.austinenergy.com/About Us/Rates/index.htm Source Parent: Comments Applicability Demand (kW) Minimum (kW): Maximum (kW): History (months): Energy (kWh)

118

Data:6566d0ea-5fa8-44a0-9769-3061ada5b1aa | Open Energy Information  

Open Energy Info (EERE)

6d0ea-5fa8-44a0-9769-3061ada5b1aa 6d0ea-5fa8-44a0-9769-3061ada5b1aa No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Nebraska Public Power District Effective date: 2013/01/01 End date if known: Rate name: Directional Lighting HPS 400 W Metered 824 Sector: Lighting Description: 824 To directional lighting of farmyards, backyards, patios, parking lots, storage yards, trailer courts, industrial sites, schools, churches, apartments, businesses, and many other applications where lighting is needed for identification, merchandising, environment, aesthetics, safety, protection, or convenience. Equipment Rental Charge means the district will install, own, operate, and maintain the lighting equipment.

119

Data:Ac089801-c85b-40ec-8ada-424ba89c3e6e | Open Energy Information  

Open Energy Info (EERE)

1-c85b-40ec-8ada-424ba89c3e6e 1-c85b-40ec-8ada-424ba89c3e6e No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: City of Blaine, Washington (Utility Company) Effective date: End date if known: Rate name: Electrical Rates - Federal Agencies Under 400 Amp Sector: Commercial Description: Source or reference: http://www.cityofblaine.com/DocumentCenter/Home/View/2461 Source Parent: Comments Applicability Demand (kW) Minimum (kW): Maximum (kW): History (months): Energy (kWh) Minimum (kWh): Maximum (kWh): History (months): Service Voltage Minimum (V): Maximum (V): Character of Service Voltage Category: Phase Wiring:

120

Data:A76d100c-a27a-403d-9136-ada03a66d4a7 | Open Energy Information  

Open Energy Info (EERE)

0c-a27a-403d-9136-ada03a66d4a7 0c-a27a-403d-9136-ada03a66d4a7 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Northeast Nebraska P P D Effective date: 2013/01/01 End date if known: Rate name: Schedule L - Metered Lighting Sector: Commercial Description: Source or reference: http://www.nnppd.com/billing/rates/ Source Parent: Comments Applicability Demand (kW) Minimum (kW): Maximum (kW): History (months): Energy (kWh) Minimum (kWh): Maximum (kWh): History (months): Service Voltage Minimum (V): Maximum (V): Character of Service Voltage Category: Phase Wiring: << Previous 1 2 3 Next >> << Previous

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Data:Fe64b4ff-5480-4a5e-ada6-6bb44608a901 | Open Energy Information  

Open Energy Info (EERE)

ff-5480-4a5e-ada6-6bb44608a901 ff-5480-4a5e-ada6-6bb44608a901 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: PUD No 1 of Okanogan County Effective date: 2013/04/01 End date if known: Rate name: Irrigation Service Schedule No. 6 Sector: Commercial Description: Electrical service for irrigation, drainage and incidental farm use. Schedule is based on continuous service for the irrigation season of April 1 through October 31. Basic Charge: $12.00 per month (during the irrigation season) Source or reference: https://www.okanoganpud.org/electric/rates/irrigation Source Parent: Comments Applicability

122

Data:Ada0589a-81ba-4b89-bfef-6695c4d9b4a8 | Open Energy Information  

Open Energy Info (EERE)

Ada0589a-81ba-4b89-bfef-6695c4d9b4a8 Ada0589a-81ba-4b89-bfef-6695c4d9b4a8 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: City of Columbus, Ohio (Utility Company) Effective date: End date if known: Rate name: Electricity Area Lighting Rates (400 MH Private Area Lighting) Sector: Commercial Description: Source or reference: http://publicutilities.columbus.gov/uploadedFiles/Public_Utilities/Document_Library/Residential_Bills_and_Payments/2011_Rates_and_Information/Electricity%20Area%20Lighting%20Rates%202011.pdf Source Parent: Comments Applicability Demand (kW) Minimum (kW): Maximum (kW): History (months):

123

Data:B186150c-7120-4086-af95-2a1f95d75ada | Open Energy Information  

Open Energy Info (EERE)

0c-7120-4086-af95-2a1f95d75ada 0c-7120-4086-af95-2a1f95d75ada No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Omaha Public Power District Effective date: 2013/01/01 End date if known: Rate name: CONSUMER OWNED STREET LIGHTING Mercury Vapor 1000 Sector: Lighting Description: CONSUMER OWNED SYSTEM OPERATED BY DISTRICT Source or reference: http://ww3.oppd.com/rates/OppdRateManual.pdf#nameddest=110 Source Parent: Comments Applicability Demand (kW) Minimum (kW): Maximum (kW): History (months): Energy (kWh) Minimum (kWh): Maximum (kWh): History (months): Service Voltage Minimum (V): Maximum (V): Character of Service

124

Data:13c42567-1f9b-44a4-bfc9-687cbd7ada86 | Open Energy Information  

Open Energy Info (EERE)

f9b-44a4-bfc9-687cbd7ada86 f9b-44a4-bfc9-687cbd7ada86 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: City of Independence, Missouri (Utility Company) Effective date: 2012/07/01 End date if known: Rate name: Private Outdoor Lighting- (175 W Mercury Vapor) Sector: Lighting Description: When mercury vapor area light fixture is mounted on an existing wood distribution pole where secondary voltage exists Source or reference: http://www.ci.independence.mo.us/PL/Rates.aspx Source Parent: Comments Applicability Demand (kW) Minimum (kW): Maximum (kW): History (months): Energy (kWh) Minimum (kWh):

125

Data:3214f6f9-77c4-490d-b77a-09ada1f3290a | Open Energy Information  

Open Energy Info (EERE)

77c4-490d-b77a-09ada1f3290a 77c4-490d-b77a-09ada1f3290a No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: City of Seneca, South Carolina (Utility Company) Effective date: End date if known: Rate name: Industrial Sector: Industrial Description: Source or reference: https://cas.sharepoint.illinoisstate.edu/grants/Sunshot/Lists/DATA%20ENTRY%20Rates%20Collected/Attachments/628/Seneca%20Light%20and%20Water.pdf Source Parent: Comments Applicability Demand (kW) Minimum (kW): Maximum (kW): History (months): Energy (kWh) Minimum (kWh): Maximum (kWh): History (months): Service Voltage Minimum (V): Maximum (V):

126

Data:807b2bcb-2fa8-4de2-ada8-c173b5342254 | Open Energy Information  

Open Energy Info (EERE)

bcb-2fa8-4de2-ada8-c173b5342254 bcb-2fa8-4de2-ada8-c173b5342254 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Salmon River Electric Coop Inc Effective date: 2006/04/01 End date if known: Rate name: Irrigation -Small Less than 30 KW Short Term Sector: Commercial Description: The type of service provided under this schedule is three phase, at secondary or primary voltage and supplied through one meter at one point of delivery. If service is provided at primary voltage, the contract for service shall specify the point of delivery, establish all metering costs to be paid by the member, and delineate ownership and control of such facilities.

127

Data:9ed9ba61-8cfa-4d35-80ee-bcd9adae3a8d | Open Energy Information  

Open Energy Info (EERE)

1-8cfa-4d35-80ee-bcd9adae3a8d 1-8cfa-4d35-80ee-bcd9adae3a8d No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Village of Stratford, Wisconsin (Utility Company) Effective date: 2008/11/18 End date if known: Rate name: Street Lighting- 400W HPS Sector: Lighting Description: This schedule will be applied to municipal street lighting and private area lighting. The utility will furnish, install, and maintain lighting units. This rate is subject to a Power Cost Adjustment, which is a charge per all kWh that varies monthly. The Commitment to Community Program Rider fee is denoted in the Flat Rate Adjustments Field.

128

Data:D93dfb4a-da6d-474d-9123-ba6d0f228916 | Open Energy Information  

Open Energy Info (EERE)

dfb4a-da6d-474d-9123-ba6d0f228916 dfb4a-da6d-474d-9123-ba6d0f228916 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Village of Ludlow, Vermont (Utility Company) Effective date: 2013/01/01 End date if known: Rate name: 07 Commercial & Industrial Demand Metered Single Phase CT Metering Customer Owned Transformer Sector: Description: Source or reference: ISU Documentation DOE Sharepoint Source Parent: Comments Applicability Demand (kW) Minimum (kW): Maximum (kW): History (months): Energy (kWh) Minimum (kWh): Maximum (kWh): History (months): Service Voltage Minimum (V): Maximum (V): Character of Service

129

Proteins' Amazing Origami Powers: Insight for Potential Disease Treatments  

Broader source: Energy.gov (indexed) [DOE]

Proteins' Amazing Origami Powers: Insight for Potential Disease Proteins' Amazing Origami Powers: Insight for Potential Disease Treatments Proteins' Amazing Origami Powers: Insight for Potential Disease Treatments October 4, 2011 - 12:46pm Addthis This is a visualization of drug molecules ("parade day-like balloons") in a simulated attack of the ribbon-like protein fibrils that are believed to be the cause of Alzheimer’s disease. Click here to see more amazing supercomputer simulations. | Image courtesy of ORNL. This is a visualization of drug molecules ("parade day-like balloons") in a simulated attack of the ribbon-like protein fibrils that are believed to be the cause of Alzheimer's disease. Click here to see more amazing

130

A New F-18 Labeled PET Agent For Imaging Alzheimer's Plaques  

SciTech Connect (OSTI)

Amyloid plaques and neurofibrillary tangles are hallmarks of Alzheimer's disease (AD). Advances in development of imaging agents have focused on targeting amyloid plaques. Notable success has been the development of C-11 labeled PIB (Pittsburgh Compound) and a number of studies have demonstrated the utility of this agent. However, the short half life of C-11 (t1/2: 20 min), is a limitation, thus has prompted the development of F-18 labeled agents. Most of these agents are derivatives of amyloid binding dyes; Congo red and Thioflavin. Some of these agents are in clinical trials with encouraging results. We have been exploring new class of agents based on 8-hydroxy quinoline, a weak metal chelator, targeting elevated levels of metals in plaques. Iodine-123 labeled clioquinol showed affinity for amyloid plaques however, it had limited brain uptake and was not successful in imaging in intact animals and humans. We have been successful in synthesizing F-18 labeled 8-hydroxy quinoline. Small animal PET/CT imaging studies with this agent showed high (7-10% ID/g), rapid brain uptake and fast washout of the agent from normal mice brains and delayed washout from transgenic Alzheimer's mice. These promising results encouraged us in further evaluation of this class of compounds for imaging AD plaques.

Kulkarni, Padmakar V.; Hao Guiyang; Arora, Veera; Long, Michael; Slavine, Nikolai; Chiguru, Srinivas; Qu Baoxi; Sun Xiankai; Bennett, Michael; Antich, Peter P.; Bonte, Frederick J. [UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390 (United States); Vasdev, Neil [CAMH PET Centre and Department of Psychiatry, University of Toronto, Toronto ONT, M5T-1R8 (Canada)

2011-06-01T23:59:59.000Z

131

Abnormal daytime sleepiness in dementia with Lewy bodies compared to Alzheimer’s disease using the Multiple Sleep Latency Test  

Science Journals Connector (OSTI)

Excessive daytime sleepiness is a commonly reported problem in dementia with Lewy bodies (DLB). We examined the relationship between nighttime sleep continuity and the propensity to fall asleep during the day ...

Tanis J Ferman; Glenn E Smith; Dennis W Dickson…

2014-12-01T23:59:59.000Z

132

Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer¿s disease from normal cognitive aging  

E-Print Network [OSTI]

inhibitors and memantine), as well as antidepressants,cholinesterase inhibitor and/or memantine, in a subset of ADInhibitor Memantine F % Taking Statins F

2013-01-01T23:59:59.000Z

133

Resource Utilisation and Cost Analysis of Memantine in Patients with Moderate to Severe Alzheimer’s Disease  

Science Journals Connector (OSTI)

Objective:...To determine the effects of 28 weeks of memantine treatment for patients with AD on resource...

Dr Anders Wimo; Bengt Winblad; Albrecht Stöffler; Yvonne Wirth…

2003-04-01T23:59:59.000Z

134

Label-Free Quantitative LC–MS Proteomics of Alzheimer’s Disease and Normally Aged Human Brains  

Science Journals Connector (OSTI)

GO processes are the categories defined in the Gene Ontology project. ... Note that 41 out of 197 proteins are flagged with “CIM” standing for “complete informative missingness”, meaning that they were observed in all 10 samples in one group and not observed in any of 10 samples of another group. ...

Victor P. Andreev; Vladislav A. Petyuk; Heather M. Brewer; Yuliya V. Karpievitch; Fang Xie; Jennifer Clarke; David Camp; Richard D. Smith; Andrew P. Lieberman; Roger L. Albin; Zafar Nawaz; Jimmy El Hokayem; Amanda J. Myers

2012-05-05T23:59:59.000Z

135

Serotonin 5-HT6 Receptor Antagonists for the Treatment of Cognitive Deficiency in Alzheimer’s Disease  

Science Journals Connector (OSTI)

Lindner, M. D.; Hodges, D. B., Jr; Hogan, J. B.; Orie, A. F.; Corsa, J. A.; Barten, D. M.; Polson, C.; Robertson, B. J.; Guss, V. L.; Gillman, K. W.; Starrett, J. E., Jr.; Gribkoff, V. K. ... Lindner, Mark D.; Hodges, Donald B., Jr.; Hogan, John B.; Orie, Anitra F.; Corsa, Jason A.; Barten, Donna M.; Polson, Craig; Robertson, Barbara J.; Guss, Valerie L.; Gillman, Kevin W.; Starrett, John E., Jr.; Gribkoff, Valentin K. ...

Bellinda Benhamú; Mar Martín-Fontecha; Henar Vázquez-Villa; Leonardo Pardo; María L. López-Rodríguez

2014-05-21T23:59:59.000Z

136

Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer¿s disease from normal cognitive aging  

E-Print Network [OSTI]

Pullman R, Bressman SS, Flint Beal M: Metabolomic profilingMatson WR, Henchcliffe C, Beal MF, Bogdanov M: MetabolomicK, Matson TD, Newhall KM, Beal MF, Brown RH Jr, Kaddurah-

2013-01-01T23:59:59.000Z

137

Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer¿s disease from normal cognitive aging  

E-Print Network [OSTI]

FDA approval of florbetapir F18 injection. N Engl J Medand the florbetapir F18 PET scan—for the detection of

2013-01-01T23:59:59.000Z

138

Data:Dd1e1a9d-dc62-479a-ada5-cd015624c86b | Open Energy Information  

Open Energy Info (EERE)

e1a9d-dc62-479a-ada5-cd015624c86b e1a9d-dc62-479a-ada5-cd015624c86b No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Northeast Nebraska P P D Effective date: 2013/01/01 End date if known: Rate name: LP2 Large Power Service - Sub-Transmission Substation Sector: Industrial Description: 1.1 This Rate Schedule LP-2 is offered for the entire electrical requirements at a single location of any industrial or manufacturing Customer requiring 5,000 kVa or more of installed transformer capacity, and for which there exists an executed power Purchase Contract between the Customer and the District. Resale of energy taken under this rate schedule by the Customer is not permitted.

139

Data:5ebd20e8-220d-40ad-a43c-ded8ebbba944 | Open Energy Information  

Open Energy Info (EERE)

ebd20e8-220d-40ad-a43c-ded8ebbba944 ebd20e8-220d-40ad-a43c-ded8ebbba944 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Cedarburg Light & Water Comm Effective date: 2011/01/01 End date if known: Rate name: Small Power Optional Time-of-Day Rate - between 50kW and 200kW Demand Primary Metering and Transformer Ownership Discount Sector: Industrial Description: "On-Peak" period: 8 a.m. to 8 p.m., Monday through Friday, excluding holidays. Customers on this or the optional time-of-day rate who are metered on the primary side receive a discount. A discount is also available for customers who own and maintain their own transformer.

140

Data:0ada1957-9e17-45f9-9171-b4e69af2b2c1 | Open Energy Information  

Open Energy Info (EERE)

ada1957-9e17-45f9-9171-b4e69af2b2c1 ada1957-9e17-45f9-9171-b4e69af2b2c1 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Coast Electric Power Assn Effective date: 2011/04/01 End date if known: Rate name: Light Service Ornamental 175 W w/ Ornamental Pole Sector: Lighting Description: *Fixed monthly charge is the sum of fixture charge, energy charge, and pole charge. Adjustment includes power cost adjustment rider and tax expense adjustment rider Source or reference: http://www.coastepa.com/documents/Rate7H.pdf Source Parent: Comments Applicability Demand (kW) Minimum (kW): Maximum (kW): History (months):

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
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they are not comprehensive nor are they the most current set.
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141

Data:7543b570-f6e7-4edb-be1b-803a1764ada2 | Open Energy Information  

Open Energy Info (EERE)

70-f6e7-4edb-be1b-803a1764ada2 70-f6e7-4edb-be1b-803a1764ada2 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Jackson County Rural E M C Effective date: 2011/10/01 End date if known: Rate name: Primary Service(Option Y-Flat Rate) Sector: Commercial Description: Character of Service - Alternating current, sixty Hz, at a nominal voltage of 7,200 volts phase to ground and 12,470 volts phase to phase Availability - Available to any account with capacity requirements of 2500 kVa or less. A customer taking service under this schedule must have a written agreement with Jackson County REMC that clarifies customer duties and responsibilities.

142

Data:B8243a0f-d6b8-4171-ba0f-dafd77ad6ada | Open Energy Information  

Open Energy Info (EERE)

43a0f-d6b8-4171-ba0f-dafd77ad6ada 43a0f-d6b8-4171-ba0f-dafd77ad6ada No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Otter Tail Power Co Effective date: 2011/10/01 End date if known: Rate name: LARGE GENERAL SERVICE - TIME OF DAY Secondary Shoulder Sector: Commercial Description: Facilities Charge per Month per annual max. kW (minimum 80 kW per Month) Less than 1000 kW: $0.33/kW Greater than or equal to 1000 kW: $0.24/kW RULES AND REGULATIONS: Terms and conditions of this electric rate schedule and the General Rules and Regulations govern use of this service. CC APPLICATION OF SCHEDULE: This schedule is applicable to nonresidential Customers with a measured Demand of at least 80 kW within the most recent 12 months.

143

Data:66943ada-bbe5-45dd-b5da-94fc2bffa63d | Open Energy Information  

Open Energy Info (EERE)

ada-bbe5-45dd-b5da-94fc2bffa63d ada-bbe5-45dd-b5da-94fc2bffa63d No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: City of Springfield, Oregon (Utility Company) Effective date: 2012/04/01 End date if known: Rate name: Private Lighting 400 W MV L-3 Sector: Lighting Description: New Lighting systems shall be overhead construction consisting of wood poles, aerial circuits, and conventional street lighting luminaries with mast arms not longer than ten feet, or floodlighting luminaries with no mast arms. The installed luminaries shall use low-pressure sodium lamps. All equipment used to provide service under this schedule will be furnished, owned, operated and maintained by the Springfield Utility Board.

144

Data:C17942b6-ada9-4d27-b902-a8dc1a8cea90 | Open Energy Information  

Open Energy Info (EERE)

b6-ada9-4d27-b902-a8dc1a8cea90 b6-ada9-4d27-b902-a8dc1a8cea90 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: City of Marshfield, Wisconsin (Utility Company) Effective date: 2012/02/01 End date if known: Rate name: Cp-2 Large Power Time-of-Day Service between 200kW and 500kW Demand Primary Metering Discount Sector: Industrial Description: Power Cost Adjustment Clause - All metered rates shall be subject to a positive or negative power cost adjustment charge equivalent to the amount by which the current cost of power (per kilowatt-hour of sales) is greater or lesser than the base cost of power purchased (per kilowatt-hour of sales). The base cost of power (U) is $0.0515 per kilowatt-hour.

145

Data:811e388a-7802-47ad-a218-22f235907b91 | Open Energy Information  

Open Energy Info (EERE)

e388a-7802-47ad-a218-22f235907b91 e388a-7802-47ad-a218-22f235907b91 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: City of Chattanooga, Tennessee (Utility Company) Effective date: 2011/10/01 End date if known: Rate name: SMSB- Season Large Manufacturing Sector: Industrial Description: This rate shall apply to the firm electric power requirements where (a) a customer's currently effective contract demand is greater than 5,000 kW but not more than 15,000 kW and (b) the major use of electricity is for activities conducted at the delivery point serving that customer which are classified with a 2-digit Standard Industrial Classification Code between 20 and 39

146

Data:8d338ada-7bd9-41e6-950d-fd4a447a6f5b | Open Energy Information  

Open Energy Info (EERE)

ada-7bd9-41e6-950d-fd4a447a6f5b ada-7bd9-41e6-950d-fd4a447a6f5b No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Wisconsin Rapids W W & L Comm Effective date: 2009/01/01 End date if known: Rate name: General Service TOU Single Phase (8am to 8pm) Sector: Commercial Description: This rate schedule is optional to all Gs-1, General Service customers. Customers that wish to be served on this rate schedule must apply to the utility for service. Once an optional customer begins service on this rate schedule, the customer shall remain on the rate for a minimum of one year. (8am to 8pm) This rate is subject to a Public Benefits Charge of 3% of the combined monthly electric charges, not to exceed $1.75.

147

Data:F344f0f2-403a-496b-ada2-58f1dc6b8504 | Open Energy Information  

Open Energy Info (EERE)

f2-403a-496b-ada2-58f1dc6b8504 f2-403a-496b-ada2-58f1dc6b8504 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Village of Mt Horeb, Wisconsin (Utility Company) Effective date: 2009/04/01 End date if known: Rate name: Gs-2 General Service Three Phase Optional Time-of-Day 7am-7pm with Parallel Generation(20kW or less) Sector: Commercial Description: Power Cost Adjustment Clause - All metered rates shall be subject to a positive or negative power cost adjustment charge equivalent to the amount by which the current cost of power (per kilowatt-hour of sales) is greater or lesser than the base cost of power purchased (per kilowatt-hour of sales). The base cost of power (U) is $0.0753 per kilowatt-hour.

148

Data:E43ada81-47c3-4830-a717-6cb806a5e67e | Open Energy Information  

Open Energy Info (EERE)

ada81-47c3-4830-a717-6cb806a5e67e ada81-47c3-4830-a717-6cb806a5e67e No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Park Electric Coop Inc Effective date: End date if known: Rate name: Residential - Net-Metered - Base #2 Sector: Residential Description: * Service on this schedule is limited to single phase consumers requiring not more than 50 KVA of installed transformer capacity. Park Electric will provide as standard service, up to 200 Amp capacity for the base rate. Over 200 Amp service will be $.50 per KVA in excess of 15 KVA plus the base rate. Line extension minimums under contract will supersede these minimums, if the line extension minimum is higher.

149

Data:Adae4065-2bd9-492f-a94e-89243675cb0d | Open Energy Information  

Open Energy Info (EERE)

Adae4065-2bd9-492f-a94e-89243675cb0d Adae4065-2bd9-492f-a94e-89243675cb0d No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: City of Plymouth, Wisconsin (Utility Company) Effective date: 2011/12/22 End date if known: Rate name: Gs-1 Rural General Service Single Phase Sector: Commercial Description: Power Cost Adjustment Clause - All metered rates shall be subject to a positive or negative power cost adjustment charge equivalent to the amount by which the current cost of power (per kilowatt-hour of sales) is greater or lesser than the base cost of power purchased (per kilowatt-hour of sales). The base cost of power (U) is $0.0774 per kilowatt-hour.

150

Data:De88db36-773b-4fd0-ada2-2e0336056d9e | Open Energy Information  

Open Energy Info (EERE)

8db36-773b-4fd0-ada2-2e0336056d9e 8db36-773b-4fd0-ada2-2e0336056d9e No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Austin Energy Effective date: End date if known: Rate name: Large Primary Service - Industrial TOU Sector: Industrial Description: * This rate is applicable to electric service required by any customer who receives service at 12,500 volts (nominal) or higher and whose demand for power meets or exceeds 3,000 kilowatts for any two months within the previous twelve months or as determined by the City of Austin. This rate is also available for buildings, parks, and other establishments owned and operated by the City of Austin that implement conservation and peak shaving technologies, such as thermal energy storage systems.

151

Data:A0129e7a-ada7-491c-8707-28ed1f0a5388 | Open Energy Information  

Open Energy Info (EERE)

e7a-ada7-491c-8707-28ed1f0a5388 e7a-ada7-491c-8707-28ed1f0a5388 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Decatur County Rural E M C Effective date: 2010/04/01 End date if known: Rate name: SECURITY LIGHT ELECTRIC SERVICE (HIGH PRESSURE SODIUM) 20,000 lumens Sector: Lighting Description: Dusk to dawn lighting service, using photo-electric controlled equipment, mast arm, street light type luminare with lamp, maintenance of the complete assembly and the cost of electrical operation are included in this service. Any additional investment beyond one span of secondary line and one pole, for the sole purpose of providing this service, will require a contribution by the member.

152

Data:909cb0ad-9159-40ad-a117-2d7740c2d61e | Open Energy Information  

Open Energy Info (EERE)

cb0ad-9159-40ad-a117-2d7740c2d61e cb0ad-9159-40ad-a117-2d7740c2d61e No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Nodak Electric Coop Inc Effective date: 2012/05/20 End date if known: Rate name: GS High Density-Single Phase Sector: Industrial Description: Additional Meters (Off-Peak Included) $ 3.60/Meter/Month Available for service to locations in a High Density area. A High Density area is defined as: ï‚· An enlargement (generally 160 acres) with 20 or more active locations, or ï‚· A cluster of 20 or more active locations, or ï‚· A cluster with 10 or more active locations that adjoins an enlargement with 20 or more active locations, or ï‚· An area adjacent to an incorporated town with 20 or more active locations. Renewable Energy Market Adjustment $0.003/KWH (Added to All Above Energy Rates) Controlled Water Heater Credit $.00736/KWH Applies to the first 1,000 KWHs each month (October-March)

153

Data:Aa1ada0c-ecbc-424e-90d6-76a85c64d44b | Open Energy Information  

Open Energy Info (EERE)

ada0c-ecbc-424e-90d6-76a85c64d44b ada0c-ecbc-424e-90d6-76a85c64d44b No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Two Rivers Water & Light Effective date: 2011/01/01 End date if known: Rate name: General Service- Three-Phase- Time-of-Day- 8am-8pm Sector: Commercial Description: This rate schedule is optional to all Gs-1, General Service customers. Customers that wish to be served on this rate schedule must apply to the utility for service. Once an optional customer begins service on this rate schedule, the customer shall remain on the rate for a minimum of one year. Any customer choosing to be served on this rate schedule waives all rights to billing adjustments arising from a claim that the bill for service would be less on another rate schedule than under this rate schedule.

154

Data:Be99b22c-ada5-4bc1-9834-4d02f14f3307 | Open Energy Information  

Open Energy Info (EERE)

9b22c-ada5-4bc1-9834-4d02f14f3307 9b22c-ada5-4bc1-9834-4d02f14f3307 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: City of Orangeburg, South Carolina (Utility Company) Effective date: 2008/10/01 End date if known: Rate name: 2US75 - 15,000 Lumens (HPS) Caged Acorn, Underground wiring Sector: Lighting Description: The following is the rate schedule for lights installed for customers on the Department's standard poles which are a part of the Department's distribution system. Source or reference: http://www.orbgdpu.com/PDF%20files/Electric%20-%20Code%202L,2P,2U%20-%20Overhead%20Private%20Lights.pdf

155

Data:Ac9ace5f-ac04-4662-ada3-21a5711f4d40 | Open Energy Information  

Open Energy Info (EERE)

ace5f-ac04-4662-ada3-21a5711f4d40 ace5f-ac04-4662-ada3-21a5711f4d40 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: City of Johnson City, Tennessee (Utility Company) Effective date: 2003/10/01 End date if known: Rate name: SECURITY LIGHTS 250 WATT SODIUM VAPOR Sector: Lighting Description: PRESENT RATES FOR SECURITY LIGHTS - EFFECTIVE 10/1/03 - PLUS POLE CHARGE WHERE APPLICABLE Source or reference: http://www.jcpb.com/yourBusiness/meters/rates.asp#rateSheet Source Parent: Comments Applicability Demand (kW) Minimum (kW): Maximum (kW): History (months): Energy (kWh) Minimum (kWh): Maximum (kWh): History (months):

156

Data:16d43cdb-9ada-48ed-8cce-7c36c72d0e24 | Open Energy Information  

Open Energy Info (EERE)

cdb-9ada-48ed-8cce-7c36c72d0e24 cdb-9ada-48ed-8cce-7c36c72d0e24 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Corn Belt Energy Corporation Effective date: End date if known: Rate name: RATE 4 GENERAL SERVICE - THREE-PHASE(NR) Sector: Commercial Description: Applicable to commercial and industrial consumers for all uses including lighting, heating and power, subject to the established rules and regulations of the cooperative. Approval of the cooperative must be obtained prior to installation of any motor requiring starting current in excess of 260 amperes. Source or reference: http://www.cornbeltenergy.com/images/pdfs/701-04%20northern%20rate%204%20effective%2004-07.pdf

157

Data:A635059e-f9e8-43bd-815b-9ada9adc795c | Open Energy Information  

Open Energy Info (EERE)

9e-f9e8-43bd-815b-9ada9adc795c 9e-f9e8-43bd-815b-9ada9adc795c No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Northern Indiana Pub Serv Co Effective date: 2011/12/27 End date if known: Rate name: General Service - Small - Three Phase Sector: Commercial Description: TO WHOM AVAILABLE Available to non-residential General Service Customers for electric service who are located on the Company's Distribution Lines suitable and adequate for supplying the service requested, subject to the conditions set forth in this Rate Schedule and the Company Rules. CHARACTER OF SERVICE The Company will supply service from its electric supply lines at only such frequency, phase, regulation, and one standard secondary voltage or the available primary voltage as it has in the location where service is required. (See Company Rule 3 for the Company's standard voltages.) DETERMINATION OF AMOUNT OF ELECTRIC SERVICE SUPPLIED The electric service to be supplied under this Rate shall be measured as to Energy consumption by a Watt-Hour meter to be installed by the Company.

158

Data:31b4c8cc-8bc6-48ad-a00f-76ca719d7ef0 | Open Energy Information  

Open Energy Info (EERE)

c8cc-8bc6-48ad-a00f-76ca719d7ef0 c8cc-8bc6-48ad-a00f-76ca719d7ef0 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: City of Mascoutah, Illinois (Utility Company) Effective date: 2011/05/01 End date if known: Rate name: Customer Area Lighting Service- Rate 7: Mercury Vapor, 16,000 Lumen, 400 Watt Sector: Lighting Description: Note: pole rental add $1.00 per month Source or reference: Rates Binder 1, Illinois State University Source Parent: Comments Applicability Demand (kW) Minimum (kW): Maximum (kW): History (months): Energy (kWh) Minimum (kWh): Maximum (kWh): History (months): Service Voltage Minimum (V):

159

Data:Adae2e5a-c205-4ed9-abb9-0fd35eb235a6 | Open Energy Information  

Open Energy Info (EERE)

Adae2e5a-c205-4ed9-abb9-0fd35eb235a6 Adae2e5a-c205-4ed9-abb9-0fd35eb235a6 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: City of Williams - AZ, Arizona (Utility Company) Effective date: End date if known: Rate name: Residential Service (E 12) Sector: Description: Source or reference: Rate Binder#4 (Illinois State University) Source Parent: Comments Applicability Demand (kW) Minimum (kW): Maximum (kW): History (months): Energy (kWh) Minimum (kWh): Maximum (kWh): History (months): Service Voltage Minimum (V): Maximum (V): Character of Service Voltage Category: Phase Wiring: << Previous 1 2 3 Next >> << Previous

160

Data:Fcd6d1ad-a904-4a0b-94a6-e8c4396e132b | Open Energy Information  

Open Energy Info (EERE)

Fcd6d1ad-a904-4a0b-94a6-e8c4396e132b Fcd6d1ad-a904-4a0b-94a6-e8c4396e132b No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Town of Spiceland, Indiana (Utility Company) Effective date: 2013/02/01 End date if known: Rate name: Residential- Water Heater Service (75 gallons or greater capacity) Sector: Residential Description: Source or reference: Rate Binder#1 (Illinois State University) Source Parent: Comments Applicability Demand (kW) Minimum (kW): Maximum (kW): History (months): Energy (kWh) Minimum (kWh): Maximum (kWh): History (months): Service Voltage Minimum (V): Maximum (V): Character of Service Voltage Category:

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Twisted Protein Aggregates and Disease: The Stability of Sickle Hemoglobin Fibers M. S. Turner,1,* R.W. Briehl,2  

E-Print Network [OSTI]

in diseases from Alzheimer's to sickle cell disease. In this Letter we argue that the twisted nature be fundamentally responsible for the meta- stability, and hence proliferation of, pathological sickle cell fibers. Sickle cell hemoglobin (HbS) possesses a single muta- tion at the #12;6 site (glu ! val) leading

Turner, Matthew

162

Data:B392cd0d-6ada-4b87-b87d-58b413afe8de | Open Energy Information  

Open Energy Info (EERE)

2cd0d-6ada-4b87-b87d-58b413afe8de 2cd0d-6ada-4b87-b87d-58b413afe8de No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Indianapolis Power & Light Co Effective date: 2011/03/15 End date if known: Rate name: MU-1 - a1a - 400 watt MH Sector: Commercial Description: Lamps in enclosed fixtures, suspended from mast arms on wood poles and supplied from overhead circuits. APPLICABILITY: For Street and Traffic Lighting of public streets, parkways, improved alleys, boulevards, drives, bridges, parking areas, or other public places by Cities or Towns or by individuals, groups of individuals, associations and other than incorporated municipalities; and lighting of public parks, drives, bridges, parking areas or other public places by only Cities or Towns where there is a prospect that the capital expenditure is warranted. The capital expenditure will be warranted if the amount of revenue received in sixty (60) months exceeds the estimated cost of installation for the lights as calculated by the Company. If the 60-month revenue does not exceed the cost of installation, the Customer must pay two and one-half (2½) times the difference of the cost of installation and the 60-month revenue prior to installation of the lighting. The terms, prices and provisions of this rate schedule shall be applicable to a consolidated city of the first class only to the extent not inconsistent with the specifications, terms, prices and provisions in contracts which may be entered into by such city pursuant to I.C. § 36-9-9-1, et. seq.

163

Data:5617ac0e-3c6b-40ad-a852-daee53a7a636 | Open Energy Information  

Open Energy Info (EERE)

ac0e-3c6b-40ad-a852-daee53a7a636 ac0e-3c6b-40ad-a852-daee53a7a636 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Nodak Electric Coop Inc Effective date: End date if known: Rate name: Commercial - Distribution Delivery - Three Phase Sector: Commercial Description: Applies to all customers who historically meet the following criteria: 1. average greater than 50 KW monthly demand per year, or 2. have a monthly demand greater than 100 KW two or more times per year, or 3. require service to an irrigation site. Load Management Options - Two options are available to C/I customers who wish to lower their coincidental demand charges by participating in the Load Management Program. 1. Full load management - Under full load management, the customer is expected to curtail load during all hours of load management. Under this option, the customer can avoid all seasonal coincidental demand charges. 2. Incremental pricing - Customers also have the option of purchasing energy during certain control periods. Nodak will provide a signal at the load management receiver indicating whether or not incremental energy is available. The customer is responsible to monitor the load management system status. If the customer chooses to operate through periods when incremental energy is available, coincidental demand charges will not accrue; however, an incremental adder will be charged for each kilowatt-hour consumed during those hours. These charges are as follows: Irrigation incremental adder up to *$0.12/Kwh All other C/I accounts incremental adder up to *$0.095/Kwh

164

Data:80f185e9-049d-4656-8d8a-da1c73e6c807 | Open Energy Information  

Open Energy Info (EERE)

85e9-049d-4656-8d8a-da1c73e6c807 85e9-049d-4656-8d8a-da1c73e6c807 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Idaho Power Co Effective date: 2012/06/01 End date if known: Rate name: Schedule 55 - Power Cost Adjustment Sector: Description: BASE POWER COST The Base Power Cost of the Company's rates is computed by dividing the sum of the Company's power cost components by firm kWh sales. The power cost components are segmented into three categories: Category 1, Category 2 and Category 3. Category 1 power costs include the sum of fuel expense and purchased power expense (excluding purchases from cogeneration and small power producers), less the sum of off-system surplus sales revenue and revenue from market-based special contract pricing. Category 2 power costs include purchased power expense from cogeneration and small power producers. Category 3 power costs include demand response incentive payments. The Base Power Cost is 1.5102 cents per kWh, which is comprised of Category 1 power costs of 0.9699 cents per kWh, Category 2 power costs of 0.4549 cents per kWh and Category 3 power costs of 0.0854 cents per kWh.

165

Data:28f84daa-f868-4b80-ada2-4c9b92450967 | Open Energy Information  

Open Energy Info (EERE)

daa-f868-4b80-ada2-4c9b92450967 daa-f868-4b80-ada2-4c9b92450967 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Reedsburg Utility Comm Effective date: 2011/06/01 End date if known: Rate name: Cp-5 Coincident Demand Metering Rider Sector: Industrial Description: Application: Available to customers with multiple service entrances on contiguous property whose conjunctive demand at either the 4 kV or 69 kV service voltage levels in excess of 5,000 kilowatts (kW) per month for three or more months in a consecutive 12-month period with a load management system to reduce the customer's conjunctive load. Under this option, customers may choose to receive a single bill for multiple metered service points. The options described in this rider are voluntary. Billing Determinants: All the provisions of the Cp-4 rates schedule shall apply. Determination of Meter Charges: The monthly meter charge will equal the Cp-4 meter charge for the voltage level(s), plus an additional meter charge times the number of additionally metered locations. Determination of Distribution Demand: The Distribution Demand will equal the sum of the distribution demands of each metered locations. Determination of Maximum Coincident Demand: The Maximum Coincident Demand in any month shall be the greatest demand resulting from the combination of all separately metered services, which occurs in any 15 consecutive minutes during each month. Determination of Billed Demand: The Billed Demand is the Maximum Coincident On-Peak Demand.

166

Data:978d8818-4d6f-48d8-9bf0-923051e7ada7 | Open Energy Information  

Open Energy Info (EERE)

818-4d6f-48d8-9bf0-923051e7ada7 818-4d6f-48d8-9bf0-923051e7ada7 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: United Illuminating Co Effective date: 2008/10/22 End date if known: Rate name: FCDE Sector: Description: Availability: This Rider is available to any customer who installs a fuel cell to meet all or part of their load requirements and takes service in accordance with General Service Time-of-Use Rate GST or Large power Time-of-Use Rate LPT. In order to comply with Section 118 of Public Act 07-242, any demand charges incurred for the operation of a fuel cell in which loss of power is due to an interruption of distribution service or fuel cell unit shutdown occurring in the off-peak hours will be reviewed on a case by case basis, and billing adjustments will be made as appropriate. The Company will rely on information and communications from the customer describing and supporting a claim for waiver of a demand charge, and on meter and other technical data associated with both the fuel cell and the Company's distribution service location in order to qualify and quantify a charge amount to be waived. The charge waived will not exceed the amount result ing from the problem or shutdown.

167

Visualizing Brain Metals in Health and Disease  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Visualizing Brain Metals in Health and Visualizing Brain Metals in Health and Disease figure 1 Fig. 1. Rapid-scanning x-ray fluorescence mapping ex perimental setup. Synchrotron x-rays at 11 keV passed through a 50 µm aperture (Ap). The beam intensity was monitored with a N2-filled ion chamber (I0). The brain slice was mounted vertically on a motorized stage (St) at 45° to the incident x-ray beam and raster scanned in the beam. A 13-element Ge detector (Ge) was positioned at a 90° angle to the beam. We all require iron, copper and zinc for normal brain function but metal metabolism becomes dysregulated in a variety of neurodegenerative diseases. Metals accumulate in Alzheimer's dementia and Parkinson's disease and are deficient in Menkes disease. Whether excess metals appear as a cause or a

168

From genetics to pathology: tau and a–synuclein assemblies in neurodegenerative diseases  

Science Journals Connector (OSTI)

...protein kinase genes. The use of lithium chloride as a speci c inhibitor...four repeats may result in an excess of tau over available binding...Lee, V. M.-Y. 1997 Lithium reduces tau phosphorylation...Diaz-Nido, J. 1997 Lithium inhibits Alzheimer's disease-like...

2001-01-01T23:59:59.000Z

169

Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and alpha-synucleinopathies  

Science Journals Connector (OSTI)

...protein kinase genes. The use of lithium chloride as a speci c inhibitor...It therefore seems that an excess of tau over available binding...Lee, V. M.-Y. 1997 Lithium reduces tau phosphorylation...Diaz-Nido, J. 1997 Lithium inhibits Alzheimer's disease-like...

1999-01-01T23:59:59.000Z

170

Data:82bc8ea2-8b5c-4fec-a440-32b1c2a7ada9 | Open Energy Information  

Open Energy Info (EERE)

8b5c-4fec-a440-32b1c2a7ada9 8b5c-4fec-a440-32b1c2a7ada9 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: East Central Oklahoma Elec Coop Inc Effective date: 1996/05/02 End date if known: Rate name: Pumping Time of Use (Three-Phase), Schedule TOU-P Sector: Commercial Description: Business and industrial pumping service. Minimum Charge shall be the highest of: (a) Customer Charge of 15.00; or (b) As prescribed by the line extension policy of the rules and regulations of the Cooperative Subject to Power Cost Adjustment and Tax Adjustment Source or reference: Rates Binder B #4 Source Parent:

171

E-Print Network 3.0 - alzheimer type hypoperfusion Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sample search results for: alzheimer type hypoperfusion Page: << < 1 2 3 4 5 > >> 1 Brain (1997), 120, 12291244 Spatial-and object-based attentional deficits in Summary: , and...

172

Brain Imaging with Positron Emission Tomography: Quantification and Biomedical Applications in Alzheimer's Disease and Brain Tumors  

E-Print Network [OSTI]

AB, Elson LM. The human brain coloring book. 1st ed. New21. Toga AW, Mazziotta JC. Brain mapping : the systems. SanSR, Phelps ME. Imaging Brain Function with Positron Emission

Wardak, Mirwais

2013-01-01T23:59:59.000Z

173

Targeting the brain : identifying and inhibiting harmful protein-amyloid interactions in Alzheimer's disease  

E-Print Network [OSTI]

NANOpure DIamond water purification system from Barnstead (NANOpure DIamond water purification system from Barnstead (

Habib, Lila K.

2011-01-01T23:59:59.000Z

174

In Vivo Characterization of CLR01, an Aggregation and Toxicity Inhibitor, with an Alzheimer's Disease Focus  

E-Print Network [OSTI]

structural basis of protein folding and its links with human93. Dobson CM (2003) Protein folding and misfolding. NatureCM (2004) Principles of protein folding, misfolding and

Attar, Aida

2013-01-01T23:59:59.000Z

175

E-Print Network 3.0 - alzheimer disease victim Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Fact ... Source: Washington University in St. Louis, Department of Psychology, Cognitive Control and Psychopathology Laboratory Collection: Biology and Medicine 3...

176

E-Print Network 3.0 - alzheimer disease gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

on ... Source: Washington University in St. Louis, Department of Psychology, Cognitive Control and Psychopathology Laboratory Collection: Biology and Medicine 2 SSV 2010...

177

E-Print Network 3.0 - alzheimer disease analise Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Fact ... Source: Washington University in St. Louis, Department of Psychology, Cognitive Control and Psychopathology Laboratory Collection: Biology and Medicine 3...

178

E-Print Network 3.0 - alzheimer disease Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Fact ... Source: Washington University in St. Louis, Department of Psychology, Cognitive Control and Psychopathology Laboratory Collection: Biology and Medicine 3...

179

E-Print Network 3.0 - alzheimers disease facts Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

... Source: Washington University in St. Louis, Department of Psychology, Cognitive Control and Psychopathology Laboratory Collection: Biology and Medicine 3 From the...

180

Journal of Alzheimer's Disease 28 (2012) 823837 DOI 10.3233/JAD-2011-110989  

E-Print Network [OSTI]

) to evaluate whether all or only a subset of semantic domains are impaired in MCI patients; and 2) to assess the neural substrate of the semantic impairment in MCI patients using voxel-based analysis of MR grey matter participated in this study. All subjects underwent a full neuropsychological assessment, along with a battery

Barbeau, Emmanuel J.

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

From Auditory and Visual to Immersive Neurofeedback: Application to Diagnosis of Alzheimer's Disease  

E-Print Network [OSTI]

Advanced Institute of Science and Technology, South Korea elgendi@ntu.edu.sg, jdauwels@ntu.edu.sg, fvialatte@brain.riken.jp, mconstable@ntu.edu.sg, cia@brain.riken.jp, Abstract. In neurofeedback, brain waves immersive activity is enjoyable, stimulating, and can have a healing effect. As an illustration

Cichocki, Andrzej

182

Recommendations for ICT use in Alzheimer's Disease assessment: Monaco CTAD expert meeting  

E-Print Network [OSTI]

and NeuroSciences, Maastricht University Medical Center, Maastricht, the Netherlands 15 Palo Alto Veterans Affairs Health Care System, Palo Alto, CA and Department of Psychiatry and Behavioral Sciences, Stanford systems within the aging population. It is therefore important to develop better instruments for assessing

Paris-Sud XI, Université de

183

E-Print Network 3.0 - alzheimer disease molecular Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

WESLEYAN.EDU ISSUE II 2011 33 As a young neurologist at Massachusetts General Hospital in the early 1960s, Don Price '56 Summary: by awareness of growing debility and lost...

184

Sleep and markers of cardiovascular disease risk in elderly Alzheimer's caregivers  

E-Print Network [OSTI]

as previous heart attack, heart failure, angina, heartn (%) Includes heart attack, heart failure, angina, heartas previous heart attack, heart failure, angina, heart

Schwartz, Jennifer

2012-01-01T23:59:59.000Z

185

Alzheimer's disease skin fibroblasts selectively express a bradykinin signaling pathway mediating  

E-Print Network [OSTI]

, is generated under conditions known as risk factors for AD, including stroke and traumatic head injury. BK B2 increases I/L B2 BK receptors in AD skin fibroblasts In established human fetal lung fibroblast models of protein kinase C (PKC). We now show that skin fibro- blasts of patients with AD developing around age 35

Steinbach, Joe Henry

186

Therapy of addition for Alzheimer's Disease: combination with galantamine and memantine  

Science Journals Connector (OSTI)

The efficacy, safety, and tolerability of nootropic cholinergic agent: GALANTAMINE (with a dual mechanism of action on the cholinergic a system) and moderate affinity NMDA- receptor antagonist: MEMANTINE, were as...

Julio Zarra; Luisa Schmidt

2010-04-01T23:59:59.000Z

187

Journal of Alzheimer's Disease 39 (2014) 111 DOI 10.3233/JAD-131295  

E-Print Network [OSTI]

such as cholinesterase inhibitors, memantine, antipsychotics, and antidepressants do not substantially improve

Chatterjee, Anjan

188

New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc  

E-Print Network [OSTI]

MS, Rauw G, Baker GB, Kar S. Memantine protects rat corticalAlbrecht M, Rammes G, et al Memantine improves cognition andBakchine S, Loft H. Memantine treatment in patients with

Corona, C; Pensalfini, A; Frazzini, V; Sensi, S L

2011-01-01T23:59:59.000Z

189

A novel invertebrate chordate model for Alzheimer's disease using the ascidian ciona intestinalis  

E-Print Network [OSTI]

McDonald S, Gergel I (2004) Memantine treatment in patientsNMDA receptor blockade: memantine and beyond. Nat Rev Drugyears. popular drug memantine (Namenda ® ) Alternatively,

Virata, Michael J.

2009-01-01T23:59:59.000Z

190

Improved Classification of Alzheimer's Disease Data via Removal of Nuisance Variability  

E-Print Network [OSTI]

Initiative 1 VTT Technical Research Centre of Finland,Tampere, Finland, 2 Department ofUniversity of Eastern Finland, Kuopio, Finland, 3 Department

Koikkalainen, Juha; Polonen, Harri; Mattila, Jussi; van Gils, Mark; Soininen, Hilkka; Lotjonen, Jyrki

2012-01-01T23:59:59.000Z

191

Modeling Intrinsically Disordered Proteins A number of neurodegenerative disorders such as Alzheimer's disease and Parkinson's  

E-Print Network [OSTI]

Modeling Intrinsically Disordered Proteins A number of neurodegenerative disorders for disorder, a number of these proteins can form ordered aggregates both in vitro and in vivo issue is that the characterization of intrinsically disordered proteins is quite challenging because

Goldwasser, Shafi

192

Estrogen regulation of glucose metabolism and mitochondrial function: Therapeutic implications for prevention of Alzheimer's disease  

E-Print Network [OSTI]

in the aging brain would be predicted to prevent conversion of the brain to using alternative sources of fuel Sciences, University of Southern California, School of Pharmacy Pharmaceutical Sciences Center, Los Angeles glycolysis and citric acid cycle-driven oxidative phosphorylation and ATP generation. Data derived from

Brinton, Roberta Diaz

193

Journal of Alzheimer's Disease 31 (2012) 120 DOI 10.3233/JAD-2012-120412  

E-Print Network [OSTI]

Structural Brain Atlases: Design, Rationale, and Applications in Normal and Pathological Cohorts Pravat K Brain Research Center, Gurgaon, India bDepartment of Radiology, Johns Hopkins Medicine, Baltimore, MD magnetic resonance imaging (MRI) provides anatomical information about the brain in healthy as well

Mandal, Pravat K.

194

Membrane Biophysics and Mechanics in Alzheimer's Disease Xiaoguang Yang & Sholpan Askarova & James C-M. Lee  

E-Print Network [OSTI]

-assemble into large, voltage-independent, and nonselective ion channels at cell membranes. A can also perturb.-M. Lee (*) Department of Biological Engineering, University of Missouri, 240 Agricultural Engineering and the formation of ion channel and neurotoxicity [24, 25]. There are two types of A­membrane interactions

Lee, James

195

The phase shift index for marking functional asynchrony in Alzheimer's disease patients using fMRI  

E-Print Network [OSTI]

of spontaneous low- frequency (SLF) components. By using a theoretical model for SLF components, we demonstrated that the normalized CI does not depend on the SNR of the SLF components. Further analysis shows that by taking of the SNR, and the PSI provides an accurate measure of the phase shift between SLF components. By applying

Rowe, Daniel B.

196

Microstructural white matter changes in Alzheimer's disease : a diffusion tensor imaging study  

E-Print Network [OSTI]

ROI region of interest SLF superior longitudinal fasciculuslongitudinal fasciculus (SLF) and the inferior longitudinalfor each ROI (e.g. , SLF, ILF, CP, ICp, genu, splenium).

Horne, Nikki Renee

2008-01-01T23:59:59.000Z

197

The Role of Tau Oligomers in the Onset of Alzheimer's Disease Neuropathology  

Science Journals Connector (OSTI)

Mackenzie, I. R. and Rademakers, R. ( 2007) The molecular genetics and neuropathology of frontotemporal lobar degeneration: recent developments Neurogenetics 8, 237– 248 ... Mackenzie Ian R A; Rademakers Rosa ...

María del Carmen Cárdenas-Aguayo; Laura Gómez-Virgilio; Steven DeRosa; Marco Antonio Meraz-Ríos

2014-09-30T23:59:59.000Z

198

Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset?Alzheimer?disease  

Science Journals Connector (OSTI)

...de Bruijn M H L Coulson A R Drouin J Eperon I C Nierlich D P Roe B A Sanger F Schreier P H Smith A J H Staden R Young I G ( 1981 ) Nature (London) 290 : 457...Neurochem Res 19 : 1131 – 1137 , 7824065 . 36 Palmer A M Burns M A ( 1994 ) Brain Res 645 : 338 – 342 , 8062096 . 37 Smith...

Robert E. Davis; Scott Miller; Corinna Herrnstadt; Soumitra S. Ghosh; Eoin Fahy; Leslie A. Shinobu; Douglas Galasko; Leon J. Thal; M. Flint Beal; Neil Howell; W. Davis Parker; Jr.

1997-01-01T23:59:59.000Z

199

Sleep and markers of cardiovascular disease risk in elderly Alzheimer's caregivers  

E-Print Network [OSTI]

was defined as previous heart attack, heart failure, angina,n (%) Includes heart attack, heart failure, angina, heartwas defined as previous heart attack, heart failure, angina,

Schwartz, Jennifer

2012-01-01T23:59:59.000Z

200

Data:5e8e1db1-b6b5-4916-ada5-6d2a73bb4a00 | Open Energy Information  

Open Energy Info (EERE)

e1db1-b6b5-4916-ada5-6d2a73bb4a00 e1db1-b6b5-4916-ada5-6d2a73bb4a00 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Duke Energy Carolinas, LLC Effective date: 2011/08/26 End date if known: Rate name: PP-N (NC) Non-Hydroelectric Qualifying Facilities Purchased Power Sector: Description: Source or reference: Source Parent: Comments Option A, Variable Rate, Connected to the Distribution System Applicability Demand (kW) Minimum (kW): Maximum (kW): History (months): Energy (kWh) Minimum (kWh): Maximum (kWh): History (months): Service Voltage Minimum (V): Maximum (V): Character of Service Voltage Category: Phase Wiring:

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Data:0a6670af-b5e1-4c9b-ada1-5c6e425ac375 | Open Energy Information  

Open Energy Info (EERE)

0af-b5e1-4c9b-ada1-5c6e425ac375 0af-b5e1-4c9b-ada1-5c6e425ac375 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: Village of Lodi, Ohio (Utility Company) Effective date: 2007/03/15 End date if known: Rate name: Commercial Large Power Rate-In Village Discount Sector: Commercial Description: *Applicable for three phase industrial load management service for customers with 50 kVA or greater demands and/or served at primary distribution voltage through one meter. 5% discount for being inside village limits. Subject to Power Cost Adjustment and Ohio kWh Tax. State of Ohio Kilowatt-Hour Tax Tax rates are applied to all kWH usage:

202

Data:Ebe2f59a-da2e-484b-a50b-f7e9b86dc38b | Open Energy Information  

Open Energy Info (EERE)

Ebe2f59a-da2e-484b-a50b-f7e9b86dc38b Ebe2f59a-da2e-484b-a50b-f7e9b86dc38b No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: PUD No 1 of Chelan County Effective date: 2012/01/01 End date if known: Rate name: General Service Small Industrial Demand 0-39 kW Three phase Sector: Industrial Description: AVAILABILITY: 1. This Schedule is available throughout the area of Chelan County served by the District with the exception of the Stehekin area, and is applicable to commercial, small industrial, farm power and multiple-residential light, heat and power customers. 2. This rate is divided into two parts. Part A-2 is secondary metered services and Part B-23 is primary metered customers who own their own transformers and distribution service facilities and have a peak demand less than 800 KW. Part B-23 applies to existing customers as of April 15, 1994. No new customers will be furnished service under Part B-23.

203

BAYSIDE LOT PERMIT and ADA  

E-Print Network [OSTI]

POTREROAVE ILLINOISST TO 101/280 South via Potrero Ave TO 101 North/ Golden Gate Br Turn right on S. Van Ness BRIDGE subject to long delays TO Bay Bridge 80 East TO Bay Bridge 80 East TO Downtown COURTESY OF MISSION

Derisi, Joseph

205

Steady-State Pharmacokinetics of Rivastigmine in Patients with Mild to Moderate Alzheimer’s Disease Not Affected by Co-Administration of Memantine  

Science Journals Connector (OSTI)

Background and objective: It has been shown that combining memantine and a cholinesterase inhibitor, which each affect ... The present study was conducted to determine if memantine has any effect...

Joshua Shua-Haim; Juanita Smith; Franck Picard; Greg Sedek…

2008-06-01T23:59:59.000Z

206

Parkinson's Disease  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Parkinson's Disease Parkinson's Disease Name: saabsaab Status: N/A Age: N/A Location: N/A Country: N/A Date: Around 1993 Question: I am interested in collecting information on Parkinson's Disease. Can you help me? Replies: Some possible sources include a neuroscience reference, a neurology text, a neurologist, neuroanatomy references. Basically Parkinson's disease is a movement disorder. It gets more and more difficult to move. One of the primary brain lesions associated with this disease is a shrinkage of an area in the brain stem called the substantia nigra. This is thought to be associated with the neurotransmitter dopamine and there seems to decreased production of the dopamine in this area. Some medications do seem to help including a dopamine replacement medicine called Sinemet. There are some new medicines coming out that may also help. Another exciting area is trying to get new dopamine cells to grow in the substantia nigra area, one way is to insert a needle into the area and inject immature nerve cells into the area and hope they will grow up to be mature dopamine producers, so far it is still considered somewhat experimental. The disease is thought to be caused by progressive cell loss. Some cases have been caused by people who synthesized drugs to abuse and they made a mistake and a bunch of young people took the drug and ended up with the disease. The silver lining of this is that this drug also will do the same thing in rats, so now there is an animal model for Parkinson's.

207

Whipple's Disease  

Science Journals Connector (OSTI)

...treatment currently is daily parenteral administration of streptomycin (1 g) and benzylpenicillin...hypopituitarism. . J. Caroli C. Julien B. Bonneville La maladie de Whipple. Revue generale...A. Huizenga D. C. Dahlin M. H. Power Whipples disease-report of four cases...

Florence Fenollar; Didier Raoult

2001-01-01T23:59:59.000Z

208

Wildlife Diseases  

E-Print Network [OSTI]

and avoid contact with wild rodents and rabbits. Rocky Mountain Spotted Fever Rocky Mountain Spotted Fever is a serious disease caused by the bacterium Rickettsia rick- ettsii. It can be transmitted to people by several species of ticks, including the lone...

Texas Wildlife Services

2007-03-13T23:59:59.000Z

209

Sorghum Diseases.  

E-Print Network [OSTI]

of organisms attacking seeds. Environmental conditions 1 encourage seed rot development also W~II increase the amount of damage caused by seedling disease. Vigorous seedlings produc:d from high-quality seed can withstand attack much better than low.... This fungus can cause considerable sorghum damage, although it usually is confined to individual fields or areas within fields that are occasionally flooded. Sorghum downy mildew, Sclerospora sorghi (Kulk) Weston & Uppal, was found first in Texas in 196...

Amador, Jose; Berry, Robert W.; Frederiksen, Richard A.; Horne, C. Wendell; Thames, Walter H.; Toler, Robert W.

1969-01-01T23:59:59.000Z

210

Raaometry C. D. Whiteman, J. M. Alzheimer, G. A. Anderson, and W. J. Shaw  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Raaometry Raaometry C. D. Whiteman, J. M. Alzheimer, G. A. Anderson, and W. J. Shaw Pacific Northwest Laboratory Richland, WA 99352 Introduction magnetometer to measure platform heading; a data acquisition system; and, during special calibration experiments, two single-axis rate gyroscopes. A recent paper by Alzheimer et al. (1993) describes the Sky and Motion-Sensing platforms, and a paper by Shaw and Whiteman (1993) uses a numerical radiation model to assess the engineering performance requirements of the Sky Platform stabilization system. The model, which performs angular integrations of a variety of published sky radiance distributions, estimates the irradiance measurement errors that would be produced on tilted radiometers. It also assesses the effect of oscillatory

211

Diagnosis of Alzheimer's disease patients with Rapid Cognitive1 Decline in clinical practice: interest of the Deco questionnaire.2  

E-Print Network [OSTI]

cholinesterase inhibitors or memantine, 161 (59.6%)15 experienced a stabilization (29.2%) or an improvement (30

Paris-Sud XI, Université de

212

Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study  

E-Print Network [OSTI]

use of AchE-Is (93%) and memantine (77%), average age (73.5I’s (%) Number on memantine (%) Placebo (n = 11) Curcumin 2

2012-01-01T23:59:59.000Z

213

Stressful life events, social support, and cognitive function in middle-aged adults with a family history of Alzheimer's disease  

E-Print Network [OSTI]

is evidence that both perceived stress and social support can influence brain health and cognitive function

Scharer, John E.

214

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease  

Science Journals Connector (OSTI)

...t FI. 3o*~ . Imuncyochemsr of AD bri secin wit ai,r .s wt nue. lab;edi ., ;. 'ne .t plaqe ae laeld...Sternberger, L. A., Casanova, M. F., Struble, R. G. & Price, D. L. (1986) J. Neuropathol. Exp. Neurol. 45, 56-64...

K S Kosik; C L Joachim; D J Selkoe

1986-01-01T23:59:59.000Z

215

Assessment of Alzheimer's disease risk with structural and functional magnetic resonance imaging : an arterial spin labeling study  

E-Print Network [OSTI]

175-182. Wierenga, C.E. , Stricker, N.R. , McCauley, A. ,ofAging, 30, 1276-1287. Stricker, N.H. , Schweinsburg,W. Bondi, Ph.D. , Nikki H. Stricker, Ph.D. , Amy J. Jak,

Bangen, Katherine J.

2010-01-01T23:59:59.000Z

216

Cerebral amyloid angiopathy (CAA) affects a majority of Alzheimer's disease patients and is associated with a rapid  

E-Print Network [OSTI]

hemorrhage in CAA patients. Engineering Theranostic Nanovehicles to Target Cerebrovascular Amyloid E. Agyare1

McQuade, D. Tyler

217

Exploration of the role of gangliosides and cholesterol in the mechanism of ?-amyloid neurotoxicity in Alzheimer's disease  

E-Print Network [OSTI]

observed in the brains of AD patients. Currently, a variety of evidence indicates that A?-membrane interactions play an important role in the mechanism of A? neurotoxicity. In particular, cholesterol and gangliosides were reported to be related closely...

Yoo, Suk Joon

2002-01-01T23:59:59.000Z

218

Am J Epidemiol . Author manuscript Aluminum and silica in drinking water and the risk of Alzheimers disease'  

E-Print Network [OSTI]

Am J Epidemiol . Author manuscript Page /1 10 Aluminum and silica in drinking water and the risk associations between exposure to aluminum or silica from drinking water and risk of cognitive decline, dementia of dementia, aged' 65 years and over living in 91 civil drinking water areas in Southern France. Two measures

Paris-Sud XI, Université de

219

Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease  

E-Print Network [OSTI]

Asturias, Oviedo, Spain 18. Affiliation: Servicio de Inmunología. Hospital Unviersitario de Gran Canaria Dr. Negrín. Bco. de la Ballena s/n, 35010 Las Palmas de Gran Canaria, Spain 19. Department of Geriatrics

220

Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease  

E-Print Network [OSTI]

Pharmacol. Lin, M.T. , Beal, M.F. , 2006. Mitochondrialcharacteristic of AD (Lin and Beal, 2006). AD is a complex

Bondy, Stephen Bondy C

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Drug Shows Promise for Advanced Disease  

Science Journals Connector (OSTI)

...session of the congress that the drug memantine significantly slowed the progression...transmit their signals. In contrast, memantine turns down the activity of the so-called...damage in Alzheimer's. In Germany, memantine has been approved for treating dementias...

Jean Marx

2000-07-21T23:59:59.000Z

222

Ada, Oklahoma: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

31°, -96.6783449° 31°, -96.6783449° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":34.774531,"lon":-96.6783449,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

223

Ada, Minnesota: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

9°, -96.5153463° 9°, -96.5153463° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":47.299689,"lon":-96.5153463,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

224

ADAS WORKSHOP 23-25 September 2012  

E-Print Network [OSTI]

-cation and atom-molecule reactive collisions in the cold regions of the fusion plasmas 20' F. Guzmán New molecular of the Institut de Recherche sur la Fusion Magnétique 08.50­08.55 Adjustments and ratification of the agenda. 1st 20' Discussion 10.30 Coffee #12;2nd session: Atomic physics and fusion plasma diagnostics 10

Strathclyde, University of

225

ADA Requirements for Workplace Charging Installation  

Broader source: Energy.gov [DOE]

Best Practices for installing PEV charging stations in compliance with the Americans with Disabilities Act.

226

Ada, Ohio: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

969°, -83.8227148° 969°, -83.8227148° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":40.7694969,"lon":-83.8227148,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

227

with Disabilities Act Requirements Workplace ADA Requirements...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

grasping, pinching, or twisting of the wrist or force more than 5 lbs. Excep- tion: Gas pumps Accessible Ramps A ramp or curb-cut must be accessible in order to allow for...

228

Interim Chronic Beryllium Disease  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

Establishes Departmental expectations for addressing chronic beryllium disease throughout the Department until a Departmental rule on beryllium is promulgated. This Notice was replaced by final rule 10 CFR Part 850, Chronic Beryllium Disease Prevention Program, published December 8, 1999.

1999-12-08T23:59:59.000Z

229

Global Health: Disease Eradication  

Science Journals Connector (OSTI)

...have been considered as potential candidates for eradication, but the World Health Organization (WHO) has targeted only two other diseases for global eradication after smallpox. In 1986, WHO's policymaking body, the World Health Assembly, adopted the elimination of dracunculiasis (guinea worm disease)... The most cost-effective intervention for certain infectious diseases is to eliminate them entirely. This article reviews the characteristics of potentially eradicable diseases and surveys current eradication methods.

Hopkins D.R.

2013-01-03T23:59:59.000Z

230

Host Plants and Their Diseases  

Science Journals Connector (OSTI)

The information telescoped into this section is taken in large part from the records of the Plant Disease Survey as given in the Plant Disease Reporter, Plant Diseases and from the Index of Plant Diseases in the ...

R. Kenneth Horst Ph.D.

2001-01-01T23:59:59.000Z

231

Host Plants and Their Diseases  

Science Journals Connector (OSTI)

The information telescoped in this section is taken in large part from the records of the Plant Disease Survey as given in the Plant Disease Reporter, Plant Diseases, and the Index of Plant Diseases in the United...

R. Kenneth Horst Ph.D.

1990-01-01T23:59:59.000Z

232

Radiology of thoracic diseases  

SciTech Connect (OSTI)

This book presents the essential clinical and radiologic findings of a wide variety of thoracic diseases. The authors include conventional, CT and MR images of each disease discussed. In addition, they present practical differential diagnostic considerations for most of the radiographic findings or patterns portrayed.

Swensen, S.J.; Pugatch, R.D.

1989-01-01T23:59:59.000Z

233

The Dutch Elm Disease  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Dutch Elm Disease Dutch Elm Disease Nature Bulletin No. 411-A March 20, 1971 Forest Preserve District of Cook County George W. Dunne, President Roland F. Eisenbeis, Supt. of Conservation THE DUTCH ELM DISEASE The American elm, far and away our most popular and important shade tree, is facing its most threatening enemy, the Dutch Elm Disease. A large part of them seem to be doomed unless up-to-date methods of control are used. In New England the appearance of whole towns has been changed by the loss of gigantic elms along entire streets. This same havoc is being repeated in most eastern states and, now, as far west as Missouri. The first diseased tree in Illinois was found downstate fifteen years ago. Since then, the infection has spread over most of the state, reaching the Chicago region in 1954.

234

Adventures in Infectious Diseases  

SciTech Connect (OSTI)

Dr. Susan Fisher-Hoch, Virologist and Epidemiologist, will discuss her research and travels associated with viral hemorrhagic fevers. From the Ebola outbreak in Reston, Virginia to outbreaks of Crimean Congo Hemorrhagic Fever in South Africa, Senegal, and Saudi Arabia, Dr. Fisher-Hoch has studied and tracked the pathophysiology of these viral diseases. These studies have led her from the Center for Disease Control in the United States, to Lyon, France where she was instrumental in designing, constructing, and rendering operational a laboratory capable of containing some of the world's most dangerous diseases.

Fisher-Hoch, Susan [University of Texas School of Public Health

2011-11-01T23:59:59.000Z

235

Nanomedicine and Cardiovascular Disease  

Science Journals Connector (OSTI)

Nanomedicine has become an important tool in the ... respect to cardiovascular disease and its sequelae, nanomedicine has the potential to detect and treat ... the most poignant examples of the utility of nanomedicine

Jason R. McCarthy

2010-02-01T23:59:59.000Z

236

Neuropathology of Salla disease  

Science Journals Connector (OSTI)

A neuropathological study was performed on two patients with Salla disease, one male and one female, from different families. They both died at the age of 41 years. Both patients showed increased excretion of ...

H. Autio-Harmainen; A. Oldfors; P. Sourander; M. Renlund…

1988-01-01T23:59:59.000Z

237

Periodontal Disease and Heart Health  

E-Print Network [OSTI]

Periodontal Disease and Heart Health Deaf HealthTalks Presenter: Christopher Lehfeldt, DDS Elmwood #12;X-ray showing bone loss rickwilsondmd.typepad.com Thursday, March 15, 12 #12;5. What is heart disease? · The medical name for heart disease is cardiovascular disease (CVD) · An American dies from CVD

Goldman, Steven A.

238

Handbook of Cerebrovascular Diseases  

Science Journals Connector (OSTI)

...medical education. There is a lot to keep up with. Thus, this major textbook focused on cerebrovascular diseases is timely. The second edition of Handbook of Cerebrovascular Diseases is a revised and expanded version of the first edition, published in 1994. It is a standard multiauthored book, but the... Stroke is hot right now. Even physicians who do not specialize in vascular neurology — the subspecialty that has just recently gained formal recognition — recognize that after decades of medicine's having very little to offer, therapeutic advances for ...

Mayer S.A.

2006-04-06T23:59:59.000Z

239

Health & Medicine Heart Disease  

E-Print Network [OSTI]

See Also: Health & Medicine Heart Disease· Medical Imaging· Vioxx· Matter & Energy Electronics· Technology· Medical Technology· Reference Artificial heart· Biosensor· Circuit design· Machine· Science and stretchable electronics can map waves of electrical activity in the heart with better resolution and speed

Rogers, John A.

240

Effect of tacrine, amiridine, akatinol memantine, and triazolam on phosphorylation, structure, and assembly of microtubules from brain microtubular proteins in Alzheimer diseases  

Science Journals Connector (OSTI)

In in vitro...experiments, amiridine in concentration of 100, 200, and 300 µM restored disturbed structure of microtubules assembled from tubulin and microtubule-associated proteins isolated from the brain of pat...

P. N. Shevtsov; E. F. Shevtsova…

2008-02-01T23:59:59.000Z

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Early Brain Response to Low-Dose Radiation Exposure Involves Molecular Networks and Pathways Associated with Cognitive Functions, Advanced Aging and Alzheimer's Disease  

E-Print Network [OSTI]

receptor inhibition by memantine. Cell Death Differ. 11, 18-receptor and its antagonist memantine (59). Genetic studies

Lowe, Xiu R

2009-01-01T23:59:59.000Z

242

Early Brain Response to Low-Dose Radiation Exposure Involves Molecular Networks and Pathways Associated with Cognitive Functions, Advanced Aging and Alzheimer's Disease  

E-Print Network [OSTI]

and Ingenuity Pathway Analysis (IPA 5.0). GO analyses wasdistribution (p ? 0.001). The IPA knowledge base includesgenes were also analyzed in IPA 5.0 for pathway enrichments

Lowe, Xiu R

2009-01-01T23:59:59.000Z

243

Alterations of brain and cerebellar proteomes linked to ABeta and tau pathology in a female triple-transgenic murine model of Alzheimer's disease  

E-Print Network [OSTI]

Ingenuity Pathway Analysis (IPA), we inferred the functionalKnowledge Base search using the IPA application. This tooland canonical pathways. The IPA- generated networks show the

2010-01-01T23:59:59.000Z

244

X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation  

Science Journals Connector (OSTI)

...light and electron microscopic particle counts. The remaining particles were small aggre- gates of...il t v X~e. r , . 4 a _% god By e I'd...and fluorescence-activated particle sorting (21). (Bar = 2...

D A Kirschner; C Abraham; D J Selkoe

1986-01-01T23:59:59.000Z

245

Soybean Diseases Atlas.  

E-Print Network [OSTI]

of the upper stern. In severe cases, the stem may have large lesions and numerous secondary roots may develop on the stem above the soil line. ... Lightning Injury Lightning sometimes Injures soybeans in the field. Lightning injury looks like a circular... are a clue to lightning damage. Since lightning damage can be mistaken for disease or insect injury, a careful examination of the field should be made before lightning in jury is diagnosed . ? ? Metribuzin (Sencor or Lexone) Injury Metribuzin...

Anonymous,

1979-01-01T23:59:59.000Z

246

Memantine  

Science Journals Connector (OSTI)

Two men with Alzheimer disease experienced loss of consciousness while receiving memantine [routes not stated].

2013-05-01T23:59:59.000Z

247

UNIVERSIT PARIS-SUD 11 FACULT DE PHARMACIE DE CHTENAY-MALABRY  

E-Print Network [OSTI]

BRAMBILLA POLYMERIC NANOPARTICLES AS ORIGINAL THERANOSTIC APPROACH FOR ALZHEIMERS DISEASE soutenue le : 11

Paris-Sud XI, Université de

248

Memantine  

Science Journals Connector (OSTI)

Memantine is used as an anti-dementia drug... Alzheimer’s disease . It reduces glutamatergic neurotransmission by acting as a low-affinity NMDA-rece...

Theodora Duka

2010-01-01T23:59:59.000Z

249

Foot-and-Mouth Disease  

Science Journals Connector (OSTI)

...Greenport, New York 11944 Foot-and-mouth disease (FMD...AGENT The recent outbreaks of foot-and-mouth disease (FMD...vesicular lesions on the tongue, feet, snout, and teats (see Pathogenesis...production, and loss of draught power, resulting in a loss in productivity...

Marvin J. Grubman; Barry Baxt

2004-04-01T23:59:59.000Z

250

The ethics of disease eradication  

Science Journals Connector (OSTI)

Abstract This paper provides an examination of the ethics of disease eradication policies. It examines three arguments that have been advanced for thinking that eradication is in some way ethically exceptional as a policy goal. These are (1) global eradication has symbolic importance, (2) disease eradication is a global public good and (3) disease eradication is a form of rescue. It argues that none of these provides a good reason to think that individuals have special duties to facilitate eradication campaigns, or that public health authorities have special permissions to pursue them. But the fact that these arguments fail does not entail that global disease eradication is ethically problematic, or that it should not be undertaken. Global eradication of a disease, if successful, is a way of providing an enormous health benefit that stretches far into the future. There is no need to reach for the idea that there is a special duty to eradicate disease; the same considerations that are in play in ordinary public health policy – of reducing the burden of disease equitably and efficiently – suffice to make global disease eradication a compelling goal where doing so is feasible.

James Wilson

2014-01-01T23:59:59.000Z

251

Occupational Disease in Connecticut, 2011  

E-Print Network [OSTI]

1 Occupational Disease in Connecticut, 2011 This report covers data for 2009 and was prepared under contract for the State of Connecticut Workers' Compensation Commission, John A. Mastropietro, Chairman, as part of the Occupational Disease Surveillance Program, operated in cooperation with the Connecticut

Oliver, Douglas L.

252

Occupational Disease in Connecticut, 2014  

E-Print Network [OSTI]

Occupational Disease in Connecticut, 2014 This report covers data for 2012 and was prepared under contract for the State of Connecticut Workers' Compensation Commission, John A. Mastropietro, Chairman, as part of the Occupational Disease Surveillance Program, operated in cooperation with the Connecticut

Oliver, Douglas L.

253

Turfgrass Disease Profiles Brown Patch  

E-Print Network [OSTI]

Turfgrass Disease Profiles Brown Patch Richard Latin, Professor of Plant Pathology Brown patch to algae and moss infestation. Even mild brown patch outbreaks can spoil the appearance of golf greens and perennial ryegrass) also may sustain damage from brown patch infection. Disease Characteristics and Symptom

254

\Reuschertrolder driver projectwriteupDeb finalTableConten  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

GM Project G.6 GM Project G.6 October 2000 xi ACRONYMS LIST AAA American Automobile Association AARP American Association of Retired Persons AD Alzheimer Disease ADA Americans with Disabilities Act ADL Activities of Daily Living AFDC Aid to Families with Dependent Children AHEAD Asset and Health Dynamics Among the Oldest Old AISG American Insurance Services Group ALS Activity Limitation Status AMA American Medical Association AoA Administration on Aging BEA Bureau of Economic Analysis BLS Bureau of Labor Statistics CODES Crash Outcome Data Evaluation System DHHS Department of Health and Human Services DOE Department of Energy DOT Department of Transportation EIA Energy Information Administration EPESE Established Populations for Epidemiologic Studies of the Elderly FARS Fatality Analysis Reporting System

255

OLDER DRIVER STUDY  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

xi xi ACRONYMS LIST AAA American Automobile Association AARP American Association of Retired Persons AD Alzheimer Disease ADA Americans with Disabilities Act ADL Activities of Daily Living AFDC Aid to Families with Dependent Children AHEAD Asset and Health Dynamics Among the Oldest Old AISG American Insurance Services Group ALS Activity Limitation Status AMA American Medical Association AoA Administration on Aging BEA Bureau of Economic Analysis BLS Bureau of Labor Statistics CODES Crash Outcome Data Evaluation System DHHS Department of Health and Human Services DOE Department of Energy DOT Department of Transportation EIA Energy Information Administration EPESE Established Populations for Epidemiologic Studies of the Elderly FARS Fatality Analysis Reporting System FHWA Federal Highway Administration

257

Polyphenols, Inflammation, and Cardiovascular Disease  

Science Journals Connector (OSTI)

Polyphenols are compounds found in foods such as tea, coffee, cocoa, olive oil, and red wine and have been studied to determine if their intake may modify cardiovascular disease (CVD) risk. Historically, biolo...

Christy C. Tangney; Heather E. Rasmussen

2013-03-01T23:59:59.000Z

258

Nanomedical Theranostics in Cardiovascular Disease  

Science Journals Connector (OSTI)

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. New diagnostic and therapeutic strategies are needed to mitigate this public health issue. Advances in nanotechnology have g...

Jun Tang; Mark E. Lobatto; Joanna C. Read…

2012-02-01T23:59:59.000Z

259

Blackberry Diseases and Their Control.  

E-Print Network [OSTI]

-plant soil fumigant to^ reduce nematode populations to acceptable levels. 2 . Anthracnsse, sometimes called dieback, is a common foliage and cane disease of blackberries and is first noticeable in the spring on new shoots and a s purple- bordered... common in your area. 2. Examine roots before planting to ensure ab- sence of crown gall. 3. Do not propagate cuttings from diseased plants. 4. Choose planting sites with good air circulation. 5. Destroy all wild berry plants and brambles inl nearby...

Philley, George L.; Smith, Leon R.

1982-01-01T23:59:59.000Z

260

Diarrheal Disease in Show Swine  

E-Print Network [OSTI]

are not important as a human disease. Cryptosporidium spp protozoa can rarely cause inap- parent infection or mild diarrhea in swine. Swine are not an important source for cryptosporidiosis in humans. Giardia spp protozoal infection in swine is rare, but it does... of gain. Lawsonia intracellularis is the causative bacterium. Though it is rarely the cause of diarrheal disease in show swine, veterinarians consider this organism as a potential cause when making a differ- ential diagnosis. L. intracellularis does...

Lawhorn, D. Bruce

2007-02-27T23:59:59.000Z

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Venkatraman Ramakrishnan, Thomas A. Steitz, Ada E. Yonath, and...  

Office of Scientific and Technical Information (OSTI)

led a group from the Weizmann Institute in Israel and the Max Planck Institute in Germany. The second group was led by Venki Ramakrishnan... .'3 'Steitz also performed work at...

262

COMPETITIVE ADVERTISING WITHIN STORE FLYERS: A WINWIN Ada MIMOUNI CHAABANE*  

E-Print Network [OSTI]

1 COMPETITIVE ADVERTISING WITHIN STORE FLYERS: A WIN­WIN STRATEGY? Aîda MIMOUNI CHAABANE* Associate & Consumer Services 17, 6 (2010) 478-486" #12;2 Competitive advertising within store flyers: a win­win strategy? Abstract This study investigates the effect of competitive advertising within store flyers

Paris-Sud XI, Université de

263

E-Print Network 3.0 - atherothrombotic cardiovascular disease...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

disease, the number one killer of all Americans. Cardiovascular disease, or heart disease is the primary cause Summary: Kidney disease is both a cause and a consequence...

264

Heart Disease and Early Heart Attack Care  

E-Print Network [OSTI]

Heart Disease and Early Heart Attack Care Pamela Kostic, RN, CCCC, Chest Pain Coordinator, Stony Risk Factors · EHAC & Prevention #12;Heart disease includes a number of problems affecting the heart and the blood vessels in the heart. #12;Types of heart disease include: · Coronary artery disease (CAD) · Angina

Ohta, Shigemi

265

Treatment of Ebola virus disease  

Science Journals Connector (OSTI)

As of October 17, 2014, a total of 9,216 cases of Ebola virus disease (EVD) and 4,555...1]. Assuming no change in the control measures for this epidemic, which seems to be the most realistic scenario for several ...

Yazdan Yazdanpanah; Jose Ramon Arribas; Denis Malvy

2014-11-01T23:59:59.000Z

266

Global mapping of infectious disease  

Science Journals Connector (OSTI)

...wide community of public health cartographers...patterns we observe in space and time? This level...disease in time and space, but also measure...operationally important public health inferences...model for mining public health topics from...NY: ACM Digital Library. 111 Kittur, A...

2013-01-01T23:59:59.000Z

267

Precision Nanomedicine in Neurodegenerative Diseases  

Science Journals Connector (OSTI)

Precision Nanomedicine in Neurodegenerative Diseases ... Laboratory of NanoMedicine, Department of Cell Research and Immunology, George S. Wise Faculty of Life Science, Department of Material Science and Engineering, and the Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv 69978, Israel ... (16) This work may serve as a novel nanomedicine for therapeutic intervention in AD. ...

Meir Goldsmith; Lilach Abramovitz; Dan Peer

2014-03-25T23:59:59.000Z

268

Plant Diseases and Their Pathogens  

Science Journals Connector (OSTI)

Because this is a reference book and not one to be read for pleasure or continuity, most of you will come to the material you need in this section by way of the index or the lists of diseases given under the d...

R. Kenneth Horst Ph.D.

2001-01-01T23:59:59.000Z

269

Melanized Fungi in Human Disease  

Science Journals Connector (OSTI)

...Several blood culture systems are available, and...when making an initial assessment of fungal disease with...models of central nervous system infection with R. mackenziei...agents of central nervous system phaeohyphomycosis...Laboratory and clinical assessment of ketoconazole in deep-seated...

Sanjay G. Revankar; Deanna A. Sutton

2010-10-01T23:59:59.000Z

270

Plant Diseases and Their Pathogens  

Science Journals Connector (OSTI)

Because this book is for reference, and not one to be read for pleasure or continuity, most of you will come to the material you need in this section by way of the index or the lists of diseases given under th...

R. Kenneth Horst Ph.D.

1990-01-01T23:59:59.000Z

271

Landscape epidemiology of plant diseases  

Science Journals Connector (OSTI)

...1094/PHYTO-96-1027 Gilbert, G.S 2002Evolutionary ecology...phyto.40.021202.110417 Gilbert, G.S , S.P Hubbell...345 Webb, C.O , G.S Gilbert, and M.J Donoghue2006Phylodiversity-dependent...Pesticides Plant Diseases microbiology statistics & numerical data...

2007-01-01T23:59:59.000Z

272

Christmas disease and haemophilia in Kenya  

Science Journals Connector (OSTI)

Christmas disease and haemophilia are thought to be rare in the African, but this paper reports 5 cases of Christmas disease and 5 of haemophilia in Kenyan Africans. With improvement in diagnostic facilities more cases will probably come to light.

Charles D. Forbes; Norman MacKay; Ashfaq Alam Khan

1966-01-01T23:59:59.000Z

273

Outbreaks of porcine parvovirus disease in Panama  

Science Journals Connector (OSTI)

The first recorded isolation of porcine parvovirus (PPV) in Panama is described. The outbreaks of PPV disease...

N. Obaldia III

1991-01-01T23:59:59.000Z

274

MENINGOCOCCAL DISEASE WHAT YOU NEED TO KNOW  

E-Print Network [OSTI]

, coughing and having close social contact (living in the same household) are examples of how this disease

Missouri-Rolla, University of

275

Heart Valve Disease James S. Gammie, MD  

E-Print Network [OSTI]

Heart Valve Disease James S. Gammie, MD Professor and Chief Division of Cardiac Surgery University USA Source: CDC #12;#12;CARDIOTHORACIC SURGEON: A SURGEON THAT TREATS HEART AND LUNG DISEASE #12;Valvular Heart Disease: Common and Under-diagnosed 0 2 4 6 8 10 12 14 18 - 44 45 - 54 55 - 64 65 - 74 > 75

Weber, David J.

276

Intraoral Radiology in Equine Dental Disease  

Science Journals Connector (OSTI)

Intraoral radiographs can be valuable aids in the diagnosis and management of equine dental disease. A step-by-step method is described for taking intraoral radiographs. Specific pathologic findings in equine dental disease are discussed. Utilization of this process facilitates diagnosis and treatment of dental disease and makes it possible to make a prognosis.

David O. Klugh

2005-01-01T23:59:59.000Z

277

Coronary Heart Disease, Hypertension, Stroke, and  

E-Print Network [OSTI]

Coronary Heart Disease, Hypertension, Stroke, and Diabetes #12;Coronary Heart Disease: Overview by atherosclerosis ­ Narrowing of coronary arteries, the vessels that supply the heart · Disease process: coronary and arms Myocardial infarction - heart attack, ischemia - local blood supply decreased resulting in cell

Meagher, Mary

278

Lyme Disease in Children in Southeastern Connecticut  

Science Journals Connector (OSTI)

...disease in southeastern Connecticut. Methods. Study Population. All children from five pediatric practices who were given a diagnosis of Lyme disease of recent onset were eligible to be enrolled in the study. The five pediatric practices are located in southeastern Connecticut, the area of the state with... Lyme disease has become a relatively common problem among children in areas of the country in which the disease is endemic.1,2 However, there are few prospective studies of the disease among children in the United States. Many parents fear that their ...

Gerber M.A.Shapiro E.D.Burke G.S.Parcells V.J.Bell G.L.

1996-10-24T23:59:59.000Z

279

Insight into the principles of amphipathic peptide self-assembly.  

E-Print Network [OSTI]

??Amyloid is associated with protein pathologies such as Alzheimer's disease, Parkinson's Disease, Spongiform Encephalopthies (Mad Cow's Disease), as well as Type II Diabetes. In recent… (more)

Bowerman, Charles James (1985 - ); Nilsson, Bradley L.; Ryan, Derek M. (1985 - ); Nissan, David A.; Liyanage, Wathsala N.

2012-01-01T23:59:59.000Z

280

Chapter 9 - Ebola Virus Disease  

Science Journals Connector (OSTI)

Five species of ebolavirus constitute the genus Ebolavirus, one member of the Filoviridae family. The Bundibugyo, Zaire, and Sudan ebolavirus species cause severe Ebola virus disease (EVD) outbreaks in humans whereas the Reston and Taï Forest species do not. EVD is a febrile hemorrhagic illness, which causes death in 25–90% of all clinically ill cases. EVD outbreaks occur primarily in remote villages in Central and West Africa, near tropical rainforests. The virus is transmitted to people from wild animals and spreads in the human population through human-to-human transmission. Fruit bats of the Pteropodidae family are considered to be the natural host of the Ebola virus. The laboratory diagnostic remains essential to confirm EVD cases. There is no treatment or vaccine available for either people or animals. Raising awareness of the risk factors of Ebola infection and the protective measures individuals can take is the only way to reduce human infection and death.

Pierre Formenty

2014-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Therapeutic target for protozoal diseases  

DOE Patents [OSTI]

A novel Fasciclin Related Adhesive Protein (FRAP) from Plasmodium and related parasites is provided as a target for therapeutic intervention in diseases caused by the parasites. FRAP has been shown to play a critical role in adhesion to, or invasion into, host cells by the parasite. Furthermore, FRAP catalyzes the neutralization of heme by the parasite, by promoting its polymerization into hemozoin. This invention provides methods and compositions for therapies based on the administration of protein, DNA or cell-based vaccines and/or antibodies based on FRAP, or antigenic epitopes of FRAP, either alone or in combination with other parasite antigens. Methods for the development of compounds that inhibit the catalytic activity of FRAP, and diagnostic and laboratory methods utilizing FRAP are also provided.

Rathore, Dharmendar (Blacksburg, VA); Jani, Dewal (Blacksburg, VA); Nagarkatti, Rana (Blacksburg, VA)

2008-10-21T23:59:59.000Z

282

Soil Fumigation for Plant Disease Control.  

E-Print Network [OSTI]

AGRICULTURAL AND MECHANICAL COLLEGE OF TEXAS T- 0. WALTON, President [Blank Page in Original Bulletin] The control of soit-borne plant diseases by soil fumigation hm been nhown to be efficient and practicable in greenhouses, seed Ws, cold frames, small... diseases. Undesirable weeds are als~ frequently present. This bulletin deals with soil fumigation clesignecl especially to control these disease-producing organisms that infest the soil. It is based on experi- ments conducted in the last seven years...

Young, P. A. (Paul Allen); Godfrey, G. H. (George Harold)

1943-01-01T23:59:59.000Z

283

N E W S AN D V I E W S NATURE MEDICINE VOLUME 12 | NUMBER 7 | JULY 2006 763  

E-Print Network [OSTI]

on Alzheimer disease published in 2004a Reference Times cited Tariot, P.N. Memantine treatment in patients

Cai, Long

284

Memantine  

Science Journals Connector (OSTI)

Three patients developed worsening or de novo agitation and visual hallucinations during memantine treatment for probable Alzheimer's disease.

2007-07-01T23:59:59.000Z

285

E-Print Network 3.0 - alpha -type protein Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

University Collection: Biotechnology ; Biology and Medicine 10 Modeling Intrinsically Disordered Proteins A number of neurodegenerative disorders such as Alzheimer's disease...

286

E-Print Network 3.0 - affects alpha-synuclein processing Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Polytechnique, Centre de mathmatiques Collection: Mathematics 47 Modeling Intrinsically Disordered Proteins A number of neurodegenerative disorders such as Alzheimer's disease...

287

Enzyme replacement therapy for Pompe disease  

E-Print Network [OSTI]

Transport of Active Enzymes to Lysosomes. Molecular therapyOF CALIFORNIA, SAN DIEGO Enzyme Replacement Therapy forDisease……………………………… 3 1.3 Enzyme Replacement Therapy for

Burris, Ryan Jonathan William

2010-01-01T23:59:59.000Z

288

"Artificial" brains, electrical grids, and disease modeling:...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Science discoveries unveiled "Artificial" brains, electrical grids, and disease modeling: Los Alamos science discoveries unveiled September 15 The event is an opportunity for...

289

Functional cardiovascular assessment in congenital heart disease.  

E-Print Network [OSTI]

??abstractAdequate and serial functional cardiovascular assessment is important in patients with congenital heart disease because many show disruption of normal myocardial geometry, which may or… (more)

W.J.B.W. van den Berg

2007-01-01T23:59:59.000Z

290

Metabolic Prosthesis for Treating Ischemic Diseases - Energy...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

have developed a new approach for treating ischemic diseases that will deliver oxygen directly to affected tissues by electrolysis of body fluids. Numerous treatments...

291

The definitive version is available at www.blackwell-synergy.com Analysis of the effect of aluminum in drinking water  

E-Print Network [OSTI]

of aluminum in drinking water and transferrin C2 allele on Alzheimer's disease. a Virginie Rondeau, b Albert.Rondeau@isped.u-bordeaux2.fr Key words: aluminum, drinking water, transferrin, apolipoprotein E, Alzheimer's disease Word of a link between aluminum in drinking water and Alzheimer's disease (AD) has been supported by several

Paris-Sud XI, Université de

292

THE HUMAN GENOME & GENETIC DISEASES MED263: Bioinformatic Applications to Human Disease  

E-Print Network [OSTI]

you will learn. History of the human genome project Structure and content of the human genome HapTHE HUMAN GENOME & GENETIC DISEASES MED263: Bioinformatic Applications to Human Disease #12;WhatMap project Categories of Human Disease: Monogenic (Single gene disorders) Multigenic (Complex disorders

Gleeson, Joseph G.

293

Models of foot-and-mouth disease  

Science Journals Connector (OSTI)

...before focusing on the three foot-and-mouth disease models...their prevalence. However, foot-and-mouth disease (FMD...causes blisters on the mouth and feet (hence the name) and a deterioration...recent years, the computational power has become available to solve...

2005-01-01T23:59:59.000Z

294

HANFORD THYROID DISEASE STUDY FINAL REPORT  

E-Print Network [OSTI]

HANFORD THYROID DISEASE STUDY FINAL REPORT Study Management Team Scott Davis, Ph.D., Principal;Acknowledgments Many individuals have contributed to the success of the Hanford Thyroid Disease Study. We wish: Dr. Floyd Frost and Mr. Eugene Sobota; 3) history of Hanford: Dr. Michelle Stenejhem; 4) statistical

295

Are You at Risk for Heart Disease?  

E-Print Network [OSTI]

vessels going to the heart get narrow and clogged. A heart attack can happen when these blood vesselsAre You at Risk for Heart Disease? Healthy Heart, Healthy Family Nangangamba Ka Bang Magkaroon ng Are You at Risk for Heart Disease? Healthy Heart, Healthy Family Nangangamba Ka Bang Magkaroon ng Sakit sa

Bandettini, Peter A.

296

Coronary Heart Disease, Hypertension, Stroke, and  

E-Print Network [OSTI]

Coronary Heart Disease, Hypertension, Stroke, and Diabetes #12;Coronary Heart Disease: Overview to illnesses caused by atherosclerosis ­ Narrowing of coronary arteries, the vessels that supply the heart that radiates across the chest and arms � Myocardial infarction - heart attack, ischemia - local blood supply

Meagher, Mary

297

COLORED PHOTOGRAPHS OF PLANT DISEASE SPECIMENS  

Science Journals Connector (OSTI)

...DISEASE SPECIMENS IN the preparation of a handbook of the diseases of vegetables by the...World in 1893. In 1896 the American Electrician was established, and this magazine...a high order. In 1906 the American Electrician was absorbed by the Electrical World...

Max W. Gardner; Geo. K. K. Link

1920-06-04T23:59:59.000Z

298

Synthesis and applications of side chain-functionalized polylactic acid-based polymers and studies toward a chemical method to degrade Alzheimer's disease-related beta-amyloid peptides  

E-Print Network [OSTI]

Diamond TM (Barnstead) water purification system before use.Diamond TM (Barnstead) water purification system before use.Diamond TM (Barnstead) water purification system before use.

Rubinshtein, Mark

2011-01-01T23:59:59.000Z

299

Synthesis and applications of side chain-functionalized polylactic acid-based polymers and studies toward a chemical method to degrade Alzheimer's disease-related beta-amyloid peptides  

E-Print Network [OSTI]

NMDA receptor antagonist memantine as a symptomatologicalC. G. ; Stoffler, A. , Memantine: a NMDA receptor antagonistfor AD treatment is memantine, an N-methyl-D-aspartase (

Rubinshtein, Mark

2011-01-01T23:59:59.000Z

300

Synthesis and applications of side chain-functionalized polylactic acid-based polymers and studies toward a chemical method to degrade Alzheimer's disease-related beta-amyloid peptides  

E-Print Network [OSTI]

1999, 32 (23), 7711-7718. Ugi, I. ; Fetzer, U. ; Eholzer,isocyanides for the ugi reaction and its application to the2.2 The Ugi and Passerini reactions in organic

Rubinshtein, Mark

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Synthesis and applications of side chain-functionalized polylactic acid-based polymers and studies toward a chemical method to degrade Alzheimer's disease-related beta-amyloid peptides  

E-Print Network [OSTI]

TM (Barnstead) water purification system before use. All NMRTM (Barnstead) water purification system before use. 1-(Diamond TM (Barnstead) water purification system before use.

Rubinshtein, Mark

2011-01-01T23:59:59.000Z

302

What You Should Know About Plant Diseases.  

E-Print Network [OSTI]

of the organism can be a guide for the length of rotation. Resistant Varieties Planting disease-resistan t varieties can be the most economical way to control a disease. For many years plant breeders have been experiment- ing with the disease resistance... procedure. Ihy Heat-Small quantities of soil used in flower pots may be sterilized by placing in an oven set at 160 degrees F. for 3 to 4 hours. Electricity-Electricity may be used for steriliz- ing small quantities of boxed soil in which heating...

Horne, C. Wendell; Smith, Harlan E.

1962-01-01T23:59:59.000Z

303

Ultraviolet Germicidal Irradiation for Preventing Infectious Disease  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Ultraviolet Germicidal Irradiation for Preventing Infectious Disease Ultraviolet Germicidal Irradiation for Preventing Infectious Disease Transmission Speaker(s): Peng Xu Date: February 19, 2002 - 12:00pm Location: Bldg. 90 The transmission of tuberculosis (TB) and other infectious diseases in health-care buildings has been a recognized hazard for decades. Ultraviolet germicidal irradiation (UVGI) of upper room air is used as an engineering control method to prevent the spread of airborne infectious disease. Under full-scale conditions, the efficacy of UVGI for inactivating airborne bacterial spores and active cells was evaluated. A test room fitted with a modern UVGI system was used to conduct bio-aerosol inactivation experiments. UVGI efficacy can be affected by environmental factors such as relative humidity (RH), and air mixing

304

INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH, BANGLADESH  

E-Print Network [OSTI]

©INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH, BANGLADESH J HEALTH POPUL NUTR 2009 00 managers can target resources to identify if such clusters exist. If so, they can then ensure supervi

Scharfstein, Daniel

305

Fracture, aging and disease in bone  

E-Print Network [OSTI]

by enhancing the materials resistance to microstructuralgrowth resistance of microcracking brittle materials. J. Am.resistance to fracture of the Page 4 Fracture, Aging and Disease in Bone underlying material.

Ager, J.W.; Balooch, G.; Ritchie, R.O.

2006-01-01T23:59:59.000Z

306

Interferon antibodies in patients with infectious diseases  

Science Journals Connector (OSTI)

Interferons (IFNs) are generally recognized as the most important therapeutic agent in some infectious diseases such as chronic hepatitis B and C. Since the early clinical trials it was documented that the the...

G. Antonelli; E. Simeoni; M. Currenti; F. De Pisa; V. Colizzi…

1997-01-01T23:59:59.000Z

307

Online GIS services for mapping and sharing disease information  

Science Journals Connector (OSTI)

Disease data sharing is important for the collaborative preparation, response, and recovery stages of disease control. Disease phenomena are strongly associated with spatial and temporal factors. Web-based Geo...

Sheng Gao; Darka Mioc; Francois Anton…

2008-02-01T23:59:59.000Z

308

Foot and mouth disease in Iraq: strategy and control.  

E-Print Network [OSTI]

??Foot-and-mouth disease (FMD) is a highly infectious viral disease of cattle, pigs, sheep, goats, buffalo, and artiodactyl wildlife species. Foot-and-mouth disease virus is endemic and… (more)

Mahdi, Ali Jafar

2010-01-01T23:59:59.000Z

309

on Infectious & Reportable Diseases HEALTH & SAFETY UNIT MAY 2009  

E-Print Network [OSTI]

POLICY on Infectious & Reportable Diseases HEALTH & SAFETY UNIT MAY 2009 #12;Policy on Infectious .......................................................................................... 6 5.2 Public Health (Infectious Diseases) Regulations 1988 ............................. 6 5.3 Reporting of Injuries, Diseases & Dangerous Occurrences Regulations 1995

310

Prevent the Spread of Zoonotic Diseases  

E-Print Network [OSTI]

Take Precautions when Handling and Caring for Animals During routine care of animals, take the following precautions against spread- ing germs that cause diseases. Wear personal protective clothing and equipment Personal protective clothing, boots..., and equipment can reduce the risk of exposing other animals or people to contagious diseases. Wear boots and a set of protective clothing that you wear only when ? handling and caring for animals. Examples are hat ? coveralls ? long-sleeved shirt (cotton...

Pena, Josefa

2008-11-10T23:59:59.000Z

311

Commercial Pecans: Controlling Rosette, Diseases and Zinc Deficiency  

E-Print Network [OSTI]

Pecan losses from diseases and insufficient zinc nutrition can be prevented by following effective grove management practices. Descriptions of diseases and recommendations for controls are included....

Lee, Thomas A.; Krausz, Joseph P.

2006-04-13T23:59:59.000Z

312

Disease-Specific Symptoms and Health-Related Quality of Life in Children and Adolescents with Inflammatory Bowel Disease  

E-Print Network [OSTI]

This study assesses generic and disease-specific Health-Related Quality of Life (HRQOL) in children and adolescents with Inflammatory Bowel Disease (IBD). More specifically, the purpose of the study is to address the relationship between disease...

Vaughan-Dark, Chelsea Ann

2013-07-17T23:59:59.000Z

313

Genetic Studies of Complex Human Diseases: Characterizing SNP-Disease Associations Using Bayesian Networks  

E-Print Network [OSTI]

Detecting epistatic interactions plays a significant role in improving pathogenesis, prevention, diagnosis, and treatment of complex human diseases. Applying machine learning or statistical methods to epistatic interaction ...

Han, Bing; Chen, Xue-wen; Talebizadeh, Zohreh; Xu, Hua

2012-12-17T23:59:59.000Z

314

E-Print Network 3.0 - adults cardiovascular disease Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

disease, the number one killer of all Americans. Cardiovascular disease, or heart disease is the primary cause Summary: Kidney disease is both a cause and a consequence...

315

E-Print Network 3.0 - affect cardiovascular disease Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

disease, the number one killer of all Americans. Cardiovascular disease, or heart disease is the primary cause Summary: Kidney disease is both a cause and a consequence...

316

E-Print Network 3.0 - addressing cardiovascular disease Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

disease, the number one killer of all Americans. Cardiovascular disease, or heart disease is the primary cause Summary: Kidney disease is both a cause and a consequence...

317

E-Print Network 3.0 - apoe ko male Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of Disease Common Alzheimer's Disease Risk Variant within the CLU Summary: ; Stricker et al., 2009). Additionally, the apolipoprotein E allele 4 (APOE4)--a widely...

318

Nanomedicine approaches in vascular disease: a review  

Science Journals Connector (OSTI)

Nanomedicine approaches have revolutionized the treatment of cancer and vascular diseases, where the limitations of rapid nonspecific clearance, poor biodistribution and harmful side effects associated with direct systemic drug administration can be overcome by packaging the agents within sterically stabilized, long-circulating nanovehicles that can be further surface-modified with ligands to actively target cellular/molecular components of the disease. With significant advancements in genetics, proteomics, cellular and molecular biology and biomaterials engineering, the nanomedicine strategies have become progressively refined regarding the modulation of surface and bulk chemistry of the nanovehicles, control of drug release kinetics, manipulation of nanoconstruct geometry and integration of multiple functionalities on single nanoplatforms. The current review aims to capture the various nanomedicine approaches directed specifically toward vascular diseases during the past two decades. Analysis of the promises and limitations of these approaches will help identify and optimize vascular nanomedicine systems to enhance their efficacy and clinical translation in the future. From the Clinical Editor Nanomedicine-based approaches have had a major impact on the treatment and diagnosis of malignancies and vascular diseases. This review discusses various nanomedicine approaches directed specifically toward vascular diseases during the past two decades, highlighting their advantages, limitations and offering new perspectives on future applications.

Anirban Sen Gupta

2011-01-01T23:59:59.000Z

319

The mathematics of diseases On Modeling Hong Kong's SARS Outbreak  

E-Print Network [OSTI]

The mathematics of diseases ­ On Modeling Hong Kong's SARS Outbreak Dr. Tuen Wai Ng Department disease modeling Epidemics: bovine spongiform encephalopathy (mad cow disease) Chicken flu #12;Infectious disease modeling Mathematical models can: predict rate of spread, peak, etc., of epidemics predict effects

Ng, Tuen Wai "Patrick"

320

CAMB 630 Topics in Human Genetics and Disease Course Directors  

E-Print Network [OSTI]

on the foundations of the Human Genome Project and parallel efforts in model organisms, research in human genetics in Human Genetics and Disease: I. Genome architecture and instability (Spinner) Chromosome specific of Mendelian disease Developmental pathways and genetic disease III. Human genomic variation and disease

Plotkin, Joshua B.

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Texas Plant Disease Diagnostic Lab Information Form  

E-Print Network [OSTI]

Specific test required: Additional cost: see http://plantclinic.tamu.edu for fees. Culture ? Oak wilt ? DED ELISA ? Pierce?s disease (grape) ? Bacterial leaf scorch ? Virus ? Other: ______________ PLANT DISEASE DIAGNOSIS FORM D...: report unless specified ? do not notify Recent pesticide & chemical application Product name Date Fertilizer(s) Fungicide(s) Insecticide(s) Herbicide(s) Other Th e T e x a s P l a n t D i s e a s e D i a g n o st i c L a b o r a t o r y ( T P D D L...

Barnes, Larry W.

2009-01-16T23:59:59.000Z

322

Deep-Brain Stimulation for Parkinson's Disease  

Science Journals Connector (OSTI)

...are related to electrical stimulation and may be addressed by adjustment of device programming or discontinuation of therapy. Neurologic side effects of deep-brain stimulation include cognitive impairment, memory deficits, difficulties with speech, disequilibrium, dysphagia, and motor and sensory disturbances... A 72-year-old man with Parkinson's disease is referred for consideration of deep-brain stimulation, which involves the implantation of electrodes in one of the nuclei of the basal ganglia and can result in significant improvement in some symptoms of Parkinson's disease.

Okun M.S.

2012-10-18T23:59:59.000Z

323

Rapid molecular theranostics in infectious diseases  

Science Journals Connector (OSTI)

The increasing availability of rapid and sensitive nucleic acid testing assays for infectious diseases will revolutionize the practice of medicine by gradually reducing the need for standard culture-based microbiological methods that take at least two days. Molecular theranostics in infectious diseases is an emerging concept in which molecular biology tools are used to provide rapid and accurate diagnostic assays to enable better initial management of patients and more efficient use of antimicrobials. Essential conditions and the quality control required for the development and validation of such molecular theranostic assays are reviewed.

François J Picard; Michel G Bergeron

2002-01-01T23:59:59.000Z

324

Minimal Residual Disease in Chronic Myeloid Leukemia  

Science Journals Connector (OSTI)

...treatment with chemotherapy. In a hematologic complete remission, we know that a large portion of the leukemic cells remain out of sight. These cells, invisible to the microscopist, are the components of an important clinical problem termed "minimal residual disease." The concept of minimal residual disease... For many years hematologists have used the microscope to identify a complete remission of leukemia after treatment with chemotherapy. In a hematologic complete remission, we know that a large portion of the leukemic cells remain out of sight. These cells, ...

Löwenberg B.

2003-10-09T23:59:59.000Z

325

Exploring the Zinc Metallome of Cultured Cortical Neurons Using Synchroton Radiation X-Ray Fluorescence Microscopy  

Science Journals Connector (OSTI)

Zinc is abundant in the brain, and dysregulation of zinc ion homeostasis has been implicated in Alzheimer’s disease pathology and neuronal death after brain ischemia. Many studies have established that cytosol...

Robert A. Colvin PhD; Christian J. Stork; Yang V. Li; Barry Lai

2012-01-01T23:59:59.000Z

326

An N-Heterocyclic Amine Chelate Capable of Antioxidant Capacity and Amyloid Disaggregation  

Science Journals Connector (OSTI)

‡ Institute for Aging and Alzheimer’s Disease Research, Department of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie, Ft. ... Synthetic beta amyloid1–40 peptide was purchased from Twenty-First Century Biochemicals. ...

Kimberly M. Lincoln; Timothy E. Richardson; Lauren Rutter; Paulina Gonzalez; James W. Simpkins; Kayla N. Green

2012-08-31T23:59:59.000Z

327

Influence of Environmental Enrichment and Depleted Uranium on Behaviour, Cholesterol and Acetylcholine in Apolipoprotein E-Deficient Mice  

Science Journals Connector (OSTI)

Alzheimer’s disease is associated with genetic risk factors, of which the apolipoprotein E (ApoE) is the most prevalent, and is affected by environmental factors that include education early in life and exposure ...

P. Lestaevel; F. Airault; R. Racine; H. Bensoussan…

2014-07-01T23:59:59.000Z

328

Memantine  

Science Journals Connector (OSTI)

Memantine is an uncompetitive, moderate-affinity NMDA receptor ... moderate to severe Alzheimer’s disease, oral memantine monotherapy improved outcomes in the area of ... trial, treatment differences did not reac...

Kate McKeage

2009-10-01T23:59:59.000Z

329

Memantine  

Science Journals Connector (OSTI)

A 77-year-old man with Alzheimer’s disease and behavioural disorders received memantine, titrated by 5mg each week to 20...route of administration not stated]. After titration his behavioural disorders improved, ...

2010-08-01T23:59:59.000Z

330

Purdue Extension Muskmelon and Watermelon Diseases  

E-Print Network [OSTI]

to muskmelons than watermelons. The disease is caused by a fungus (Alternaria cucumerina) that can rapidly Conditions · A brief introduction to the Melcast concept. III. Using Melcast · Acquiring Environmental Data - A description of data requirements for running Melcast. · Translating Environmental Data into EFI Values

331

Vaccine approaches with Edinburgh Infectious Diseases  

E-Print Network [OSTI]

Vaccine approaches with Edinburgh Infectious Diseases Alexander Corbishley #12;The technology approaches to knowledge exchange · October 2013: three technology scouts seconded for 12 months, to identify Congress 2014 (Washington DC) · Local partnering meetings with SMEs · Discussions with Open Innovation

Maizels, Rick

332

MFR PAPER 1143 A Septicemic Bacterial Disease  

E-Print Network [OSTI]

in Galveston. Mortalities from this disease ranged from a few shrimp lost per day in some cases to nearly 100 of Veterinary Microbiology, Texas A&M Univer- sity, College Station, TX 77843. This paper is Contribution No. 372 of the Galveston Laboratory, Gulf Coastal Fisheries Center, NMFS, NOAA, Galveston, TX 77550. food

333

Free membership Agriculture Alzheimer Astronomy  

E-Print Network [OSTI]

Ecology Energy Engineering Environment Genetics Geology Global warming HIV Health Heart Immune system Life geophysics Browse Articles Category: All Articles Better Bioremediation at Uranium Mill Tailings Site Published on 16 February 2009, 08:42 Last Update: 11 hour(s) ago by Insciences Tags: Uranium U

Lovley, Derek

334

Exclusion map of Salla disease: attempts to localize the disease gene using a computer program  

Science Journals Connector (OSTI)

Salla disease is a lysosomal storage disorder due to impaired transport of free sialic acid across the lysosomal membrane. The clinical presentation of this autosomal recessive trait is severe psychomotor reta...

Leena Haataja; Johanna Schlentker; Martin Renlund; Aarno Palotie…

1992-01-01T23:59:59.000Z

335

Modeling social response to the spread of an infectious disease  

E-Print Network [OSTI]

With the globalization of culture and economic trade, it is increasingly important not only to detect outbreaks of infectious disease early, but also to anticipate the social response to the disease. In this thesis, we use ...

Evans, Jane A. (Jane Amanda)

2012-01-01T23:59:59.000Z

336

Harvesting can increase severity of wildlife disease epidemics  

Science Journals Connector (OSTI)

...classes. In our model, neither catchability...However, we can predict that, in figure...infects rabbits. Our model could also potentially...disease like the avian flu that currently threatens...Resources Disease Outbreaks veterinary Models, Biological Population...

2006-01-01T23:59:59.000Z

337

Air Pollution and Oxidative Stress in Allergic Airway Diseases  

Science Journals Connector (OSTI)

With 30–40 % of the world’s population suffering from allergic diseases and with the increasing trends of this noncommunicable disease, especially in children in both the developed and developing, allergic diseas...

Ruby Pawankar M.D.; Ph.D.; F.R.C.P.; F.A.A.A.A.I.…

2014-01-01T23:59:59.000Z

338

Infectious Disease Modeling of Social Contagion in Networks  

E-Print Network [OSTI]

Many behavioral phenomena have been found to spread interpersonally through social networks, in a manner similar to infectious diseases. An important difference between social contagion and traditional infectious diseases, ...

Hill, Alison Lynn

339

Characterization of a Drosophila model of Huntington's disease  

E-Print Network [OSTI]

Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation ...

Lee, Wyan-Ching Mimi

2006-01-01T23:59:59.000Z

340

Preventing diet induced disease: bioavailable nutrient-rich, low-  

E-Print Network [OSTI]

induced disease, including the use of food nanotechnology. nanotechnology promises to transform medicine intake and noting the importance of cofactors). Micro- and nanotechnologies are already engineering nano problems and challenges for society). Key words: nanotechnology, diet, disease, cardiovascular, heart

Paris-Sud XI, Université de

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

University Guidance for the REPORTING OF ACCIDENTS, DISEASES AND  

E-Print Network [OSTI]

University Guidance for the REPORTING OF ACCIDENTS, DISEASES AND DANGEROUS OCCURANCES HEALTH INJURY, HOSPITALISATION, DISEASE AND DANGEROUS OCCURRENCES.2 Reporting Over Three Days Absence Injury.........................................2 4.3 Reporting a Dangerous

342

Women and Heart Disease: Neglected Directions for Future Research  

E-Print Network [OSTI]

009-9110-0 Women and Heart Disease: Neglected Directions forage 65, women have less heart disease than men. For many1980s showed a lower risk of heart attacks in postmenopausal

Barrett-Connor, Elizabeth

2009-01-01T23:59:59.000Z

343

Former Workers Medical Facilities with Experience Evaluating Chronic Beryllium Disease  

Broader source: Energy.gov [DOE]

This document provides a listing of medical facilities within the United States with experience in evaluating Chronic Beryllium Disease.

344

Annular lichen planus in association with Crohn disease  

E-Print Network [OSTI]

of Crohn disease and a sickle cell trait. Therapy withparasites were excluded. Sickle cell trait was diagnosed (

Serrão, Vasco Vieira; Organ, Vasili; Pereira, Luís; Vale, Esmeralda; Correia, Suzete

2008-01-01T23:59:59.000Z

345

RESEARCH OF ANIMAL DISEASE INFORMATION SYSTEM BASED ON GIS  

E-Print Network [OSTI]

in order to dynamically monitor and predict diseases distribution, and propagation, such as HPAI and FMD monitor and predict disease, as well as to support the disease prevention decision making, in order outbreak and propagation in some areas of China, . With HPAI for example,, in 2005 there were 13 areas

Boyer, Edmond

346

Modeling daily flow patterns individuals to characterize disease spread  

SciTech Connect (OSTI)

The effect of an individual's travels throughout a day on the spread of disease is examined using a deterministic SIR model. We determine which spatial and demographic characteristics most contribute to the disease spread and whether the progression of the disease can be slowed by appropriate vaccination of people belonging to a specific location-type.

Smallwood, J. (Jeanine); Hyman, J. M. (James M.); Mirchandani, Pitu B.

2002-11-17T23:59:59.000Z

347

Rapid evolutionary dynamics and disease threats to biodiversity  

E-Print Network [OSTI]

Rapid evolutionary dynamics and disease threats to biodiversity Sonia Altizer1 , Drew Harvell2 should enable hosts to respond better to future disease threats. Infectious diseases are recognized populations, or have been implicated as threats to already declining species [4­6]. Although infectious

348

A Century of Progress: Milestones in Sickle Cell Disease  

E-Print Network [OSTI]

A Century of Progress: Milestones in Sickle Cell Disease Research and Care Introduction In 1910 to be known as sickle cell disease. One hundred years later we know that the sickle-shaped cells are due take the characteristic "C"-shape that is the hallmark of sickle cell disease. What is Sickle Cell

Bandettini, Peter A.

349

Horticultural & Forest crops 2014 Floral Crops: Diseases 5-1  

E-Print Network [OSTI]

Horticultural & Forest crops 2014 Floral Crops: Diseases 5-1 Diseases Chuan Hong, Plant Pathologist humidity, low light intensity, and frequent watering, are favorable for the development of fungal and bacterial diseases. If insects are uncontrolled in the greenhouse, viruses can become a major problem

Liskiewicz, Maciej

350

The Clinical Differentiation of Primary Gout from Primary Renal Disease in Patients with Both Gout and Renal Disease  

Science Journals Connector (OSTI)

Renal disease is a well recognized complication of primary gout but it is less well recognized that ... patients with primary renal disease may also develop gout. Chronic lead nephropathy is the best recognized ....

B. T. Emmerson; P. J. Stride; Gail Williams

1980-01-01T23:59:59.000Z

351

Disparities in Emergency Department Quality of Care among Patients with and without Coronary Heart Disease Diagnoses  

E-Print Network [OSTI]

coronary heart disease and heart attack, and perceive theyheart disease and heart attack, and tend to perceive thatfor heart disease and heart attack, and do not recognize

Sammartinova, Jitka

2013-01-01T23:59:59.000Z

352

E-Print Network 3.0 - assessing disease activity Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

The disease... candidate genes for diverse diseases, even in the absence of text mining data. Gene-centric assessment... This evaluation treats each known gene-disease ......

353

E-Print Network 3.0 - advanced eye disease Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Safety PRogRam Summary: . Leptospirosis Leptospirosis is a bacterial disease that causes abortion, eye problems and kidney disease... Horse Transmitted DiseasesSaddle Up SAFELY...

354

Analysis of Dose Response for Circulatory Disease After Radiotherapy for Benign Disease  

SciTech Connect (OSTI)

Purpose: To assess the shape of the dose-response for various circulatory disease endpoints, and modifiers by age and time since exposure. Methods and Materials: This was an analysis of the US peptic ulcer data testing for heterogeneity of radiogenic risk by circulatory disease endpoint (ischemic heart, cerebrovascular, other circulatory disease). Results: There were significant excess risks for all circulatory disease, with an excess relative risk Gy{sup -1} of 0.082 (95% CI 0.031-0.140), and ischemic heart disease, with an excess relative risk Gy{sup -1} of 0.102 (95% CI 0.039-0.174) (both p = 0.01), and indications of excess risk for stroke. There were no statistically significant (p > 0.2) differences between risks by endpoint, and few indications of curvature in the dose-response. There were significant (p < 0.001) modifications of relative risk by time since exposure, the magnitude of which did not vary between endpoints (p > 0.2). Risk modifications were similar if analysis was restricted to patients receiving radiation, although the relative risks were slightly larger and the risk of stroke failed to be significant. The slopes of the dose-response were generally consistent with those observed in the Japanese atomic bomb survivors and in occupationally and medically exposed groups. Conclusions: There were excess risks for a variety of circulatory diseases in this dataset, with significant modification of risk by time since exposure. The consistency of the dose-response slopes with those observed in radiotherapeutically treated groups at much higher dose, as well as in lower dose-exposed cohorts such as the Japanese atomic bomb survivors and nuclear workers, implies that there may be little sparing effect of fractionation of dose or low-dose-rate exposure.

Little, Mark P., E-mail: mark.little@nih.gov [Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza South, Rockville, Maryland (United States); Kleinerman, Ruth A. [Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza South, Rockville, Maryland (United States)] [Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza South, Rockville, Maryland (United States); Stovall, Marilyn; Smith, Susan A. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Mabuchi, Kiyohiko [Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza South, Rockville, Maryland (United States)] [Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza South, Rockville, Maryland (United States)

2012-12-01T23:59:59.000Z

355

A study of the pecan shuck disease  

E-Print Network [OSTI]

29 Micro. 28 + Macro. 27 10 11 Cyprex 12 33 Mi cro . 34 + Zinc 35 36 37 Zinc 38 26 25 24 23 22 21 Micro. Cyprex + Macro. 13 Cyprex 14 + Micro. 15 16 Cyprex 17 + Zinc 18 0 I a 'o tU 4J m w 4J o 39 20 19... in the study of the effect of various treatments on the incidence of pecan shuck disease. 12 Fig. 3-3. John Bean sprayer used to make the foliar applications of zinc, Cyprex fungicide and microelements. A) Front view, B) Side view. 13 Table 3...

Williams, James Mclaren

1969-01-01T23:59:59.000Z

356

Hunger and Socioeconomic Disparities in Chronic Disease  

Science Journals Connector (OSTI)

...healthful foods could stem the tide of widening socioeconomic disparities in chronic disease. In developing and newly industrialized countries worldwide, food insecurity in the context of the globalization of food markets exposes low-income populations to the same low-cost, energy-dense, and nutritionally... The rate of food insecurity rose by 32% in 2008, to 14.6% of U.S. households. Drs. Hilary Seligman and Dean Schillinger argue that the widening price differential between unhealthful and healthful foods may increase socioeconomic disparities in the ...

Seligman H.K.; Schillinger D.

2010-07-01T23:59:59.000Z

357

Crohn's disease and the mycobacterioses: a review and comparison of two disease entities.  

Science Journals Connector (OSTI)

...after all? Dig. Dis. Sci. 29:1086-1088. 97. Gitnick, G., J...Thailand. Rev. Infect. Dis. 3:1085-1089. 264. Sroat, D. A. 1988. Ocular...disease. Dig. Dis. Sci. 29:1080-1085. 275. Thayer, W. R., B. Fixa...

R J Chiodini

1989-01-01T23:59:59.000Z

358

Rare is frequent and frequent is costly: rare diseases as a challenge for health care systems  

Science Journals Connector (OSTI)

Of 30,000 known diseases about 6,000–7,000 are defined as rare diseases, also commonly known as orphan diseases [1]. Within the European Union (EU), rare diseases are specified as indications with a prevalence of...

J.-Matthias Graf von der Schulenburg…

2014-10-01T23:59:59.000Z

359

OSTI, US Dept of Energy, Office of Scientific and Technical Information |  

Office of Scientific and Technical Information (OSTI)

disease Topic disease Topic Sharing Data Leads to Progress by Nena Moss 19 Aug, 2010 in Personal Perspectives My mother died in March 2010 after a 15-year battle with Alzheimer's, so I pay particular attention to news about this dreadful disease. A recent New York Times article caught my eye: "Sharing of Data Leads to Progress on Alzheimer's." How did sharing data lead to progress on Alzheimer's? A collaborative effort, the Alzheimer's Disease Neuroimaging Initiative, was formed to find the biological markers that show the progression of Alzheimer's disease in the human brain. The key was to share all the data, making every finding public immediately - "available to anyone with a computer anywhere in the world." Related Topics: ADNI, Alzheimer's, biomarkers, collaboration, corollary, data, disease, initiative, mission, neuroimaging, osti, research, sharing

360

Chronic Beryllium Disease Prevention Program Report  

SciTech Connect (OSTI)

This document describes how Lawrence Livermore National Laboratory (LLNL) meets the requirements and management practices of federal regulation 10 CFR 850, 'Chronic Beryllium Disease Prevention Program (CBDPP).' This revision of the LLNL CBDPP incorporates clarification and editorial changes based on lessons learned from employee discussions, observations and reviews of Department of Energy (DOE) Complex and commercial industry beryllium (Be) safety programs. The information is used to strengthen beryllium safety practices at LLNL, particularly in the areas of: (1) Management of small parts and components; and (2) Communication of program status to employees. Future changes to LLNL beryllium activities and on-going operating experience will be incorporated into the program as described in Section S, 'Performance Feedback.'

Lee, S

2012-03-29T23:59:59.000Z

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Automated diagnostic kiosk for diagnosing diseases  

DOE Patents [OSTI]

An automated and autonomous diagnostic apparatus that is capable of dispensing collection vials and collections kits to users interesting in collecting a biological sample and submitting their collected sample contained within a collection vial into the apparatus for automated diagnostic services. The user communicates with the apparatus through a touch-screen monitor. A user is able to enter personnel information into the apparatus including medical history, insurance information, co-payment, and answer a series of questions regarding their illness, which is used to determine the assay most likely to yield a positive result. Remotely-located physicians can communicate with users of the apparatus using video tele-medicine and request specific assays to be performed. The apparatus archives submitted samples for additional testing. Users may receive their assay results electronically. Users may allow the uploading of their diagnoses into a central databank for disease surveillance purposes.

Regan, John Frederick; Birch, James Michael

2014-02-11T23:59:59.000Z

362

FISH CONSUMPTION, METHYLMERCURY, AND HUMAN HEART DISEASE.  

SciTech Connect (OSTI)

Environmental mercury continues to be of concern to public health advocates, both in the U.S. and abroad, and new research continues to be published. A recent analysis of potential health benefits of reduced mercury emissions has opened a new area of public health concern: adverse effects on the cardiovascular system, which could account for the bulk of the potential economic benefits. The authors were careful to include caveats about the uncertainties of such impacts, but they cited only a fraction of the applicable health effects literature. That literature includes studies of the potentially harmful ingredient (methylmercury, MeHg) in fish, as well as of a beneficial ingredient, omega-3 fatty acids or ''fish oils''. The U.S. Food and Drug Administration (FDA) recently certified that some of these fat compounds that are primarily found in fish ''may be beneficial in reducing coronary heart disease''. This paper briefly summarizes and categorizes the extensive literature on both adverse and beneficial links between fish consumption and cardiovascular health, which are typically based on studies of selected groups of individuals (cohorts). Such studies tend to comprise the ''gold standard'' of epidemiology, but cohorts tend to exhibit a great deal of variability, in part because of the limited numbers of individuals involved and in part because of interactions with other dietary and lifestyle considerations. Note that eating fish will involve exposure to both the beneficial effects of fatty acids and the potentially harmful effects of contaminants like Hg or PCBs, all of which depend on the type of fish but tend to be correlated within a population. As a group, the cohort studies show that eating fish tends to reduce mortality, especially due to heart disease, for consumption rates up to about twice weekly, above which the benefits tend to level off. A Finnish cohort study showed increased mortality risks in the highest fish-consuming group ({approx}3 times/wk), which had mercury exposures (mean hair content of 3.9 ppm) much higher than those seen in the United States. As an adjunct to this cursory review, we also present some new ''ecological'' analyses based on international statistics on hair Hg, fish consumption, other dietary and lifestyle factors, and selected cardiovascular health endpoints. We searched for consistent differences between primarily fish-consuming nations, like Japan or the Seychelles, and others who traditionally eat much less fish , such as in central Europe, for example. We use data on cigarette sales, smoking prevalence surveys, and national lung cancer mortality rates to control for the effects of smoking on heart disease. These ecological analyses do not find significant adverse associations of either fish consumption or hair Hg with cardiovascular health; instead, there is a consistent trend towards beneficial effects, some of which are statistically significant. However, such ecological studies cannot distinguish differences due to variations in individual rates of fish consumption. We conclude that the extant epidemiological evidence does not support the existence of significant heart disease risks associated with mercury in fish, for the United States. The most prudent advice would continue to be that of maintaining a well-balanced diet, including fish or shellfish at least once per week. There may be additional benefits from fatty fish.

LIPFERT, F.W.; SULLIVAN, T.M.

2005-09-21T23:59:59.000Z

363

Networks and the Epidemiology of Infectious Disease  

E-Print Network [OSTI]

The science of networks has revolutionised research into the dynamics of interacting elements. It could be argued that epidemiology in particular has embraced the potential of network theory more than any other discipline. Here we review the growing body of research concerning the spread of infectious diseases on networks, focusing on the interplay between network theory and epidemiology. The review is split into four main sections, which examine: the types of network relevant to epidemiology; the multitude of ways these networks can be characterised; the statistical methods that can be applied to infer the epidemiological parameters on a realised network; and finally simulation and analytical methods to determine epidemic dynamics on a given network. Given the breadth of areas covered and the ever-expanding number of publications, a comprehensive review of all work is impossible. Instead, we provide a personalised overview into the areas of network epidemiology that have seen the greatest progress in recent ...

Danon, Leon; House, Thomas; Jewell, Chris P; Keeling, Matt J; Roberts, Gareth O; Ross, Joshua V; Vernon, Matthew C

2010-01-01T23:59:59.000Z

364

E-Print Network 3.0 - ada2p yields insight Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

InsightOversight for Commercial Crew Transportation Rev. N, March 10, 2010 Wayne Hale... to which NASA will require insight and oversight for the transportation of...

365

Adapting ADA Architectural Design Knowledge to Product Design: Groundwork for a Function Based Approach  

E-Print Network [OSTI]

and 4th digits come as a pair. For example, b 7 is neuromusculoskeletal and movement related functions, where b750 to b789 cover movement functions; b750 is motor reflex functions, b760 is control of voluntary movements, b7601 is control of complex.... (August 2010) Shraddha Chandrakant Sangelkar, B. Tech., Veermata Jijabai Technological Institute, India Chair of Advisory Committee: Dr. Daniel A. McAdams Disability is seen as a result of an interaction between a person and that person...

Sangelkar, Shraddha Chandrakant

2011-10-21T23:59:59.000Z

366

A restudy of the cylindrical amphoras from the seventh-century Yassi Ada shipwreck  

E-Print Network [OSTI]

, for red and white wine. These correlations demonstrate that, by the 1 lth c., there was a complex and controlled metrological system in use for the transportation and marketing of wine. Using the methodology developed by van Doorninck for his study...

Van Alfen, Peter Gerritt

2012-06-07T23:59:59.000Z

367

E-Print Network 3.0 - ada mutant strains Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

yhcQ mutant (strain U6) was constructed by the method... strain from ... Source: Matin, A.C. - Department of Microbiology and Immunology, Stanford University Collection: Biology...

368

E-Print Network 3.0 - ada accessibility guidelines Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Source: Texas at Austin, University of - Center for Transportation Research Collection: Energy Storage, Conversion and Utilization 54 THE NEWSLETTER OF CAMPUS DIVERSITY 1 2 A...

369

Relationship between dental disease and radiation necrosis of the mandible  

SciTech Connect (OSTI)

Preirradiation panoramic radiographs of forty-six dentate patients were examined for the presence of significant dental disease. Evidence of a positive association between dental disease present before radiation therapy and subsequent necrosis of the mandible was found leading to a recommendation that significant disease be eradicated before irradiation of oral tissues. Considerable suffering results from bone necrosis, which can be reduced by careful and rational dental diagnosis and treatment.

Murray, C.G.; Daly, T.E.; Zimmerman, S.O.

1980-02-01T23:59:59.000Z

370

Global Health: Measuring the Global Burden of Disease  

Science Journals Connector (OSTI)

...effective and high-quality care to patients without knowing their diagnoses; likewise, for health systems to be effective, it is necessary to understand the key challenges in efforts to improve population health and how these challenges are changing. Before the early 1990s, there was no comprehensive... The burden that disease places on societies around the world is complex and changing as communicable diseases are replaced by noncommunicable diseases. This article summarizes these changes and the current burden.

Murray C.J.L.; Lopez A.D.

2013-08-01T23:59:59.000Z

371

ORISE Research Participation Programs at the Centers for Disease...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Research Participation Programs at The Centers for Disease Control and Prevention Oak Ridge Institute for Science and Education Home About the CDC About ORISE Current Research...

372

ORNL, UTGSM study compares structures of Huntington's disease...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

ORNL, UTGSM study compares structures of Huntington's disease protein Researchers used neutron scattering experiments to clarify structural differences between the normal (left)...

373

Strategies of survival; lectures on population, disease, war, famine  

E-Print Network [OSTI]

Lectures on the theories of Malthus, and on disease, war and famine, including theories of McKeown, Adam Smith and Amartya Sen...

Macfarlane, Alan

2007-02-14T23:59:59.000Z

374

E-Print Network 3.0 - atherosclerotic cardiovascular disease...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the molecular Summary: .Riou@ujf-grenoble.fr > LMR and AB equally contributed to this work Abstract Cardiovascular diseases (CVD) are the leading... ; vulnerable coronary...

375

Do changes in traditional coronary heart disease risk factors over time explain the association between socio-economic status and coronary heart disease?  

E-Print Network [OSTI]

case-control study. Heart 2009, Franks P, Tancredi DJ,status in coronary heart disease risk estimation. Ann Famstatus and coronary heart disease risk prediction. JAMA

Franks, Peter; Winters, Paul C; Tancredi, Daniel J; Fiscella, Kevin A

2011-01-01T23:59:59.000Z

376

Modeling of Mitochondria Bioenergetics Using a Composable Chemiosmotic Energy Transduction Rate Law: Theory and Experimental Validation  

E-Print Network [OSTI]

2010) Modeling mitochondrial bioenerget- ics with integrated2009) Mitochondrial bioenergetic deficit precedes alzheimer’diseases. Journal of Bioenergetics and Biomembranes 40: 59–

Chang, Ivan; Heiske, Margit; Letellier, Thierry; Wallace, Douglas; Baldi, Pierre

2011-01-01T23:59:59.000Z

377

nAture methods | VOL.10 NO.2 | FEBRUARY2013 | 147 measurement of protease activity in living cells or organisms  

E-Print Network [OSTI]

, such as gout6, atherosclerosis7, type 2 diabetes8 and Alzheimer's disease9, engagement of the NLRP3­ASC

Cai, Long

378

E-Print Network 3.0 - affecting cerebrospinal fluid Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Memory Research Laboratory, University of California at San Diego Collection: Biology and Medicine 3 4.2.5 NANOTECHNOLOGY TOWARDS CLINICAL DIAGNOSIS OF ALZHEIMER'S DISEASE D....

379

E-Print Network 3.0 - assay ultra sensitive Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

A. - Division of Cell and Gene Therapy, University of Rochester Collection: Biology and Medicine 4 4.2.5 NANOTECHNOLOGY TOWARDS CLINICAL DIAGNOSIS OF ALZHEIMER'S DISEASE D....

380

Memantine  

Science Journals Connector (OSTI)

A 78-year-old woman, who was receiving memantine for Alzheimer's disease, developed myoclonus. Subsequently, while still receiving memantine, she developed delirium and exacerbation of her...

2008-03-01T23:59:59.000Z

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Donepezil/memantine  

Science Journals Connector (OSTI)

A 79-year-old woman with Alzheimer's disease (AD) developed myoclonus while receiving donepezil; myoclonus was exacerbated after addition of memantine to her therapy.

2007-08-01T23:59:59.000Z

382

Statistical shape analysis of neuroanatomical structures based on spherical wavelet transformation  

E-Print Network [OSTI]

Evidence suggests that morphological changes of neuroanatomical structures may reflect abnormalities in neurodevelopment, or relate to a variety of disorders, such as schizophrenia and Alzheimer's disease (AD). Advances ...

Yu, Peng, Ph. D. Massachusetts Institute of Technology

2008-01-01T23:59:59.000Z

383

E-Print Network 3.0 - ardb proteins reveals Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of Wisconsin at Madison Collection: Biology and Medicine 52 Modeling Intrinsically Disordered Proteins A number of neurodegenerative disorders such as Alzheimer's disease...

384

E-Print Network 3.0 - applying membrane-bound form Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

University of Sheffield Collection: Biology and Medicine 15 Abstract Amyloidogenic proteins (Ab peptide) in Alzheimer's disease (AD) and alpha-synuclein (a-Syn) Summary:...

385

OSTI, US Dept of Energy, Office of Scientific and Technical Informatio...  

Office of Scientific and Technical Information (OSTI)

the biological markers that show the progression of Alzheimer's disease in the human brain. The key was to share all the data, making every finding public immediately -...

386

E-Print Network 3.0 - atrophy affecting individuals Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sample search results for: atrophy affecting individuals Page: << < 1 2 3 4 5 > >> 1 Brain . Author manuscript Posterior cingulate hypometabolism in early Alzheimers disease:...

387

E-Print Network 3.0 - antioxidant cocktail supplementation Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

a mouse model of Alzheimer's ... Source: Wisconsin at Madison, University of - Solar Energy Laboratory Collection: Renewable Energy 54 Neurobiology of Disease Nrf2 Activation in...

388

E-Print Network 3.0 - activity recorded simultaneously Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Summary: corresponding to the gait periods were segmented from the full record, and a standard voice activity detection... simultaneously in patients with Alzheimer's disease...

389

E-Print Network 3.0 - acid docosahexaenoic acid Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

SAGE-Hindawi Access to Research International Journal of Alzheimer's Disease Summary: APP secretion 19. 2.2. Fatty Acids on Membrane Physical Properties and APP Processing. Fatty...

390

Disease avoidance as a functional basis for stigmatization  

Science Journals Connector (OSTI)

...broadening of the model allows for stigmatization...specified to predict the precise similarities...we propose a model of disease-avoidance-based...following the outbreak of severe acute...disease risk model and its alternatives...2009 Amid swine flu outbreak, racism goes...

2011-01-01T23:59:59.000Z

391

Disease avoidance as a functional basis for stigmatization  

Science Journals Connector (OSTI)

...race and disease in the 20th century America. Lancet 367, 531-533...the nineteenth and twentieth centuries. Bull. Hist. Med. 44...and nonhandicapped boys in a camp setting. J. Spec. Ed. 8...disease identity in twentieth century America. Baltimore, MD...

2011-01-01T23:59:59.000Z

392

Salivary Microbiota and Metabolome Associated with Celiac Disease  

Science Journals Connector (OSTI)

...disease (CD) under a gluten-free diet (treated celiac disease...ratios (5, 9). The gluten-free diet (GFD) is effective...properties in relation to gluten free diet in children with celiac...metabolome of children with autism and pervasive developmental...

Ruggiero Francavilla; Danilo Ercolini; Maria Piccolo; Lucia Vannini; Sonya Siragusa; Francesca De Filippis; Ilaria De Pasquale; Raffaella Di Cagno; Michele Di Toma; Giorgia Gozzi; Diana I. Serrazanetti; Maria De Angelis; Marco Gobbetti

2014-03-21T23:59:59.000Z

393

Affordable System for Rapid Detection and Mitigation of Emerging Diseases  

Science Journals Connector (OSTI)

South and South-East Asian countries are currently in the midst of a new epidemic of Dengue Fever. This paper presents disease surveillance systems in Sri Lanka and India, monitoring a handful of communicable diseases termed as notifiable. These systems ... Keywords: Alerting, Biosurveillance, Data Mining, Epidemiology, Interoperability, Mhealth, Spatio-Temporal Analysis

Nuwan Waidyanatha, Artur Dubrawski, Ganesan M., Gordon Gow

2011-01-01T23:59:59.000Z

394

Chronic Beryllium Disease Prevention Program (10 CFR 850)  

Broader source: Energy.gov [DOE]

The DOE established a chronic beryllium disease prevention program (CBDPP) to reduce the number of workers currently exposed to beryllium in the course of their work at DOE facilities managed by DOE or its contractors, minimize the levels of, and potential for, exposure to beryllium, and establish medical surveillance requirements to ensure early detection of the disease.

395

Inherited Neuronal Ion Channelopathies: New Windows on Complex Neurological Diseases  

E-Print Network [OSTI]

cause of these diseases. Key words: sodium channels; calcium channels; epilepsy; migraine; pain; genetic diseases Introduction Voltage-gated sodium and calcium channels are closely related members of the ion­IV), which each consists of six -helical trans- membrane segments (S1­S6) and a pore loop connecting S5 and S

Meisler, Miriam

396

CAMB 630 Topics in Human Genetics and Disease Course Directors  

E-Print Network [OSTI]

on the foundations of the Human Genome Project and parallel efforts in model organisms, research in human genetics in Human Genetics and Disease: I. Genome architecture and instability (Spinner) Chromosome specific variation II. Human genomic variation and disease (Devoto) History and substructure of the human population

Plotkin, Joshua B.

397

Arsenic in drinking water Increases mortality from cardiovascular disease  

E-Print Network [OSTI]

Arsenic in drinking water Increases mortality from cardiovascular disease Allan H Smith professor of inorganic arsenic in drinking water causes cancer of the skin, bladder, lung, liver, and kidney.1 2 Mounting of a link between cardiovascular disease and arsenic in drinking water came in 1980 from Antofagasta, Chile

California at Berkeley, University of

398

Status Report, Department of Energy's Chronic Beryllium Disease Prevention  

Broader source: Energy.gov (indexed) [DOE]

Status Report, Department of Energy's Chronic Beryllium Disease Status Report, Department of Energy's Chronic Beryllium Disease Prevention Program - February 2006 Status Report, Department of Energy's Chronic Beryllium Disease Prevention Program - February 2006 February 2006 Report on Implementation of 10 CFR Part 850, Chronic Beryllium Disease Prevention Program During calendar year 2005, the Office of Independent Oversight, within the Office of Security and Safety Performance Assurance, evaluated the effectiveness of U.S. Department of Energy (DOE) chronic beryllium disease protection programs (CBDPPs) at five sites as part of regularly scheduled inspections. These reviews focused on site programs for ensuring that workers are protected in accordance with the requirements of 10 CFR 850. This report summarizes the observations, insights, and lessons learned from

399

Status Report, Department of Energy's Chronic Beryllium Disease Prevention  

Broader source: Energy.gov (indexed) [DOE]

Status Report, Department of Energy's Chronic Beryllium Disease Status Report, Department of Energy's Chronic Beryllium Disease Prevention Program - February 2006 Status Report, Department of Energy's Chronic Beryllium Disease Prevention Program - February 2006 February 2006 Report on Implementation of 10 CFR Part 850, Chronic Beryllium Disease Prevention Program During calendar year 2005, the Office of Independent Oversight, within the Office of Security and Safety Performance Assurance, evaluated the effectiveness of U.S. Department of Energy (DOE) chronic beryllium disease protection programs (CBDPPs) at five sites as part of regularly scheduled inspections. These reviews focused on site programs for ensuring that workers are protected in accordance with the requirements of 10 CFR 850. This report summarizes the observations, insights, and lessons learned from

400

Ebola Virus Disease The current outbreak of Ebola Virus Disease (EVD) in West Africa has involved the  

E-Print Network [OSTI]

Ebola Virus Disease The current outbreak of Ebola Virus Disease (EVD) in West Africa has involved the countries of Sierra Leone, Liberia, Guinea, and Nigeria. This has become the largest outbreak of Ebola want to make sure you have the most accurate information about this illness. What is Ebola Virus

MacAdam, Keith

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Inefficient degradation of truncated polyglutamine proteins by the proteasome  

E-Print Network [OSTI]

Comprehensive Cancer Center, Northwestern University, Evanston, IL, USA Accumulation of mutant proteins of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and the polygluta- mine disorders that cells expressing mutant ataxin-1 or Huntingtin exhibit decreased proteasome activity

Matouschek, Andreas

402

Particulate matter and heart disease: Evidence from epidemiological studies  

SciTech Connect (OSTI)

The association between particulate matter and heart disease was noted in the mid-nineties of last century when the epidemiological evidence for an association between air pollution and hospital admissions due to cardiovascular disease accumulated and first hypotheses regarding the pathomechanism were formulated. Nowadays, epidemiological studies have demonstrated coherent associations between daily changes in concentrations of ambient particles and cardiovascular disease mortality, hospital admission, disease exacerbation in patients with cardiovascular disease and early physiological responses in healthy individuals consistent with a risk factor profile deterioration. In addition, evidence was found that annual average PM{sub 2.5} exposures are associated with increased risks for mortality caused by ischemic heart disease and dysrhythmia. Thereby, evidence is suggesting not only a short-term exacerbation of cardiovascular disease by ambient particle concentrations but also a potential role of particles in defining patients' vulnerability to acute coronary events. While this concept is consistent with the current understanding of the factors defining patients' vulnerability, the mechanisms and the time-scales on which the particle-induced vulnerability might operate are unknown.

Peters, Annette [GSF-National Research Center for Environment and Health, Institute of Epidemiology, Ingolstaedter Landstr. 1, 85764 Neuherberg (Germany)]. E-mail: peters@gsf.de

2005-09-01T23:59:59.000Z

403

Medical Progress: Tick-Borne Diseases in the United States  

Science Journals Connector (OSTI)

...reservoirs for Colorado tick fever, but other rodents and mammals, such as rabbits and deer, may be infected. Most human infections are acquired from tick bites, but the virus has been transmitted by blood transfusion. The disease occurs in mountainous regions of 11 western states: Colorado, Utah, South... In the United States, more vector-borne diseases are transmitted by ticks than by any other agent1. During the past 20 years, tick-borne diseases have taken on increased importance as humans have moved into rural areas and increased their recreational ...

Spach D.H.; Liles W.C.; Campbell G.L.

1993-09-23T23:59:59.000Z

404

OSTI, US Dept of Energy, Office of Scientific and Technical Information |  

Office of Scientific and Technical Information (OSTI)

initiative Topic initiative Topic Sharing Data Leads to Progress by Nena Moss 19 Aug, 2010 in Personal Perspectives My mother died in March 2010 after a 15-year battle with Alzheimer's, so I pay particular attention to news about this dreadful disease. A recent New York Times article caught my eye: "Sharing of Data Leads to Progress on Alzheimer's." How did sharing data lead to progress on Alzheimer's? A collaborative effort, the Alzheimer's Disease Neuroimaging Initiative, was formed to find the biological markers that show the progression of Alzheimer's disease in the human brain. The key was to share all the data, making every finding public immediately - "available to anyone with a computer anywhere in the world." Related Topics: ADNI, Alzheimer's, biomarkers, collaboration, corollary, data, disease, initiative, mission, neuroimaging, osti, research, sharing

405

OSTI, US Dept of Energy, Office of Scientific and Technical Information |  

Office of Scientific and Technical Information (OSTI)

corollary Topic corollary Topic Sharing Data Leads to Progress by Nena Moss 19 Aug, 2010 in Personal Perspectives My mother died in March 2010 after a 15-year battle with Alzheimer's, so I pay particular attention to news about this dreadful disease. A recent New York Times article caught my eye: "Sharing of Data Leads to Progress on Alzheimer's." How did sharing data lead to progress on Alzheimer's? A collaborative effort, the Alzheimer's Disease Neuroimaging Initiative, was formed to find the biological markers that show the progression of Alzheimer's disease in the human brain. The key was to share all the data, making every finding public immediately - "available to anyone with a computer anywhere in the world." Related Topics: ADNI, Alzheimer's, biomarkers, collaboration, corollary, data, disease, initiative, mission, neuroimaging, osti, research, sharing Read more...

406

OSTI, US Dept of Energy, Office of Scientific and Technical Information |  

Office of Scientific and Technical Information (OSTI)

sharing Topic sharing Topic Sharing Data Leads to Progress by Nena Moss 19 Aug, 2010 in Personal Perspectives My mother died in March 2010 after a 15-year battle with Alzheimer's, so I pay particular attention to news about this dreadful disease. A recent New York Times article caught my eye: "Sharing of Data Leads to Progress on Alzheimer's." How did sharing data lead to progress on Alzheimer's? A collaborative effort, the Alzheimer's Disease Neuroimaging Initiative, was formed to find the biological markers that show the progression of Alzheimer's disease in the human brain. The key was to share all the data, making every finding public immediately - "available to anyone with a computer anywhere in the world." Related Topics: ADNI, Alzheimer's, biomarkers, collaboration, corollary, data, disease, initiative, mission, neuroimaging, osti, research, sharing

407

OSTI, US Dept of Energy, Office of Scientific and Technical Information |  

Office of Scientific and Technical Information (OSTI)

ADNI Topic ADNI Topic Sharing Data Leads to Progress by Nena Moss 19 Aug, 2010 in Personal Perspectives My mother died in March 2010 after a 15-year battle with Alzheimer's, so I pay particular attention to news about this dreadful disease. A recent New York Times article caught my eye: "Sharing of Data Leads to Progress on Alzheimer's." How did sharing data lead to progress on Alzheimer's? A collaborative effort, the Alzheimer's Disease Neuroimaging Initiative, was formed to find the biological markers that show the progression of Alzheimer's disease in the human brain. The key was to share all the data, making every finding public immediately - "available to anyone with a computer anywhere in the world." Related Topics: ADNI, Alzheimer's, biomarkers, collaboration, corollary, data, disease, initiative, mission, neuroimaging, osti, research, sharing

408

OSTI, US Dept of Energy, Office of Scientific and Technical Information |  

Office of Scientific and Technical Information (OSTI)

biomarkers Topic biomarkers Topic Sharing Data Leads to Progress by Nena Moss 19 Aug, 2010 in Personal Perspectives My mother died in March 2010 after a 15-year battle with Alzheimer's, so I pay particular attention to news about this dreadful disease. A recent New York Times article caught my eye: "Sharing of Data Leads to Progress on Alzheimer's." How did sharing data lead to progress on Alzheimer's? A collaborative effort, the Alzheimer's Disease Neuroimaging Initiative, was formed to find the biological markers that show the progression of Alzheimer's disease in the human brain. The key was to share all the data, making every finding public immediately - "available to anyone with a computer anywhere in the world." Related Topics: ADNI, Alzheimer's, biomarkers, collaboration, corollary, data, disease, initiative, mission, neuroimaging, osti, research, sharing

409

OSTI, US Dept of Energy, Office of Scientific and Technical Information |  

Office of Scientific and Technical Information (OSTI)

neuroimaging Topic neuroimaging Topic Sharing Data Leads to Progress by Nena Moss 19 Aug, 2010 in Personal Perspectives My mother died in March 2010 after a 15-year battle with Alzheimer's, so I pay particular attention to news about this dreadful disease. A recent New York Times article caught my eye: "Sharing of Data Leads to Progress on Alzheimer's." How did sharing data lead to progress on Alzheimer's? A collaborative effort, the Alzheimer's Disease Neuroimaging Initiative, was formed to find the biological markers that show the progression of Alzheimer's disease in the human brain. The key was to share all the data, making every finding public immediately - "available to anyone with a computer anywhere in the world." Related Topics: ADNI, Alzheimer's, biomarkers, collaboration, corollary, data, disease, initiative, mission, neuroimaging, osti, research, sharing

410

Counting small RNA in disease-causing organisms  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Counting small RNA in disease-causing organisms Counting small RNA in disease-causing organisms Counting small RNA in disease-causing organisms Los Alamos researchers demonstrated improved technical methods capable of directly counting small RNA molecules in pathogenic (disease-causing) bacteria. June 17, 2013 Artist's concept of the fluorescence labeling and detection of small RNA in pathogenic bacteria. Artist's concept of the fluorescence labeling and detection of small RNA in pathogenic bacteria. The new technique reduced the number of false positives, which improved the accuracy of the count statistics, and it significantly reduced the image processing time. Small molecules of RNA (tens to hundreds of nucleotides in length) play a key regulatory role in bacteria. Due to their small size, directly

411

Retinal Diseases: Age-Related Macular Degeneration and Retinitis Pigmentosa  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Retinal Diseases: Age-Related Macular Degeneration and Retinitis Pigmentosa Retinal Diseases: Age-Related Macular Degeneration and Retinitis Pigmentosa Age-related macular degeneration (AMD) is an eye disease primarily affecting the central vision regions in people age 60 and older. According to the Macular Degeneration Research Fund, a case of AMD is diagnosed in the United States every 3 minutes. Each year, 1.2 million of the estimated 12 million people with AMD will suffer severe vision loss. Patients with AMD have dark areas in their vision caused by fluid leakage or bleeding in the macula, the center of the retina that produces the sharpest vision. The brain initially compensates for these dark patches. Early cellular dysfunction or spotting in the macula may go undetected until the disease is in advanced stages.

412

Current drivers and future directions of global livestock disease dynamics  

Science Journals Connector (OSTI)

...demand models other than...and HPAI outbreaks or threats...ability to predict changes is...Endemic disease outbreaks Greater private...and other models Livestock Revolution...2005 ) Models of foot-and-mouth...Web data predict flu . Nature...

Brian D. Perry; Delia Grace; Keith Sones

2013-01-01T23:59:59.000Z

413

Ebola virus disease: an update for anesthesiologists and intensivists  

Science Journals Connector (OSTI)

Ebola virus disease (EVD) is a viral hemorrhagic fever that is highly transmissible and all too often rapidly fatal. Recent outbreaks in West Africa reveal that this infection has the potential to be transmitt...

Duane J. Funk MD; Anand Kumar MD

2014-11-01T23:59:59.000Z

414

An Analysis of some Necrotic Virus Diseases of the Potato  

Science Journals Connector (OSTI)

1 June 1932 research-article An Analysis of some Necrotic Virus Diseases of the Potato Redcliffe N. Salaman F. C. Bawden The Royal Society is collaborating with JSTOR to digitize, preserve, and extend access to...

1932-01-01T23:59:59.000Z

415

Crinkle "A," an Infectious Disease of the Potato  

Science Journals Connector (OSTI)

14 January 1930 research-article Crinkle "A," an Infectious Disease of the Potato Redcliffe N. Salaman The Royal Society is collaborating with JSTOR to digitize, preserve, and extend access to Proceedings of...

1930-01-01T23:59:59.000Z

416

Brief Report: Recombinant Osteoprotegerin for Juvenile Paget's Disease  

Science Journals Connector (OSTI)

The change in the size and shape of the skeleton during growth and its renewal during adult life depend on the closely coordinated activity of bone-resorbing cells (osteoclasts) and bone-forming cells (osteoblasts). The receptor activator of nuclear factor-?B (RANK) ligand (RANKL)–osteoprotegerin–RANK... Juvenile Paget's disease, a genetic bone disease characterized by accelerated bone turnover, results from inactivating mutations in the gene encoding osteoprotegerin, a key regulator of osteoclastogenesis. The authors investigated the effects of recombinant osteoprotegerin in two adult siblings with juvenile Paget's disease. After 15 months, radial bone mass had increased, skeletal bisphosphonate retention had decreased, and there was radiographic improvement. Osteoprotegerin may be therapeutic in juvenile Paget's disease.

Cundy T.Davidson J.Rutland M.D.Stewart C.DePaoli A.M.

2005-09-01T23:59:59.000Z

417

Infectious diseases of animals and plants: an interdisciplinary approach  

Science Journals Connector (OSTI)

...interdisciplinary approach to studying the management of infectious...and natural science research...interdisciplinary approach, combining...and social sciences, to disease management. Firstly...interdisciplinary approach to studying the management of infectious...and natural science research...

2011-01-01T23:59:59.000Z

418

Global Change and Human Vulnerability to Vector-Borne Diseases  

Science Journals Connector (OSTI)

...climate change scenarios because solutions require the design of strategies...range of circumstances. Natural solutions for vector-borne diseases are...gas from the ground into the air by burning fossil fuels. The global consumption juggernaut...

Robert W. Sutherst

2004-01-01T23:59:59.000Z

419

Global Change and Human Vulnerability to Vector-Borne Diseases  

Science Journals Connector (OSTI)

...diseases depends on three capacities: effective...constraints (244) or sustainability and robustness (309...http://www.sustainability.com/philosophy...the key principles of sustainability are to think long-term...to grave, forms one pillar of any information...

Robert W. Sutherst

2004-01-01T23:59:59.000Z

420

What college students should know about Meningococcal Disease  

E-Print Network [OSTI]

. Sometimes these bacteria invade the body to infect the lining of the brain (causing meningitis. Brain damage, hearing loss, loss of limbs, or kidney failure can also occur. Meningococcal disease

Wisconsin at Madison, University of

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Collaborative Help in Chronic Disease Management: Supporting Individualized Problems  

E-Print Network [OSTI]

Collaborative Help in Chronic Disease Management: Supporting Individualized Problems ABSTRACT for how diabetes patient support groups help one another find individualized strategies for managing diabetes community, and interviews, we found several help interactions that are critical in helping

Anderson, Richard

422

A biophysical marker of severity in sickle cell disease  

E-Print Network [OSTI]

The search for predictive indicators of disease has largely focused on molecular markers. However, biophysical markers, which can integrate multiple pathways, may provide a more global picture of pathophysiology. Sickle ...

Mahadevan, L.

423

Involvement of interleukin-4 and -10 in inflammatory bowel disease  

Science Journals Connector (OSTI)

The pathogenesis of ulcerative colitis (UC) and Crohn's disease (CD) may be associated with a decreased production of cytokines suppressing macrophage and T-cell functions: interleukins (IL) -4 and IL-10. Seru...

Dr. O. H. Nielsen MD; DMSc; T. Køppen MSc…

1996-09-01T23:59:59.000Z

424

Status Report, Department of Energy's Chronic Beryllium Disease...  

Broader source: Energy.gov (indexed) [DOE]

of 10 C.F.R. Part 850, Chronic Beryllium Disease Prevention Program, at the Department of Energy (DOE). The report is based on the results of evaluations of the effectiveness of...

425

Ruptured sinus of valsalva masquerading as rheumatic heart disease  

Science Journals Connector (OSTI)

Ruptured sinus of Valsalva is a rare lesion in pediatric age group. We are reporting a twelve year old child with hyperdynamic circulation being diagnosed and treated as Rheumatic heart disease.

Mukesh Kumar Beniwal; Dinesh Kumar Yadav; Pankaj Kumar Gupta

2012-10-01T23:59:59.000Z

426

artery disease involving: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

E. Lundquist; James P. Ward 72 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

427

Disease Manifestations and Pathogenic Mechanisms of Group A Streptococcus  

Science Journals Connector (OSTI)

...streptococcal disease among household contacts of case patients and...respiratory tract pathogens in Japan. Int. J. Infect. Dis. 9...Streptococcus pyogenes isolated in Japan from patients with severe invasive...Beta-Haemolytic Streptococci in Japan. 2007. Distribution of emm...

Mark J. Walker; Timothy C. Barnett; Jason D. McArthur; Jason N. Cole; Christine M. Gillen; Anna Henningham; K. S. Sriprakash; Martina L. Sanderson-Smith; Victor Nizet

2014-04-01T23:59:59.000Z

428

Striatal origin of the pathologic beta oscillations in Parkinson's disease  

E-Print Network [OSTI]

Enhanced oscillations at beta frequencies (8–30 Hz) are a signature neural dynamic pathology in the basal ganglia and cortex of Parkinson's disease patients. The mechanisms underlying these pathological beta oscillations ...

Boyden, Edward Stuart

429

Red Blood cell Alloimmunization in Sickle Cell Disease: Pathophysiology, Risk Factors, and Transfusion Management  

E-Print Network [OSTI]

1 Red Blood cell Alloimmunization in Sickle Cell Disease: Pathophysiology, Risk Factors; email: france.noizat-pirenne@efs.sante.fr Keywords: sickle cell disease, alloimmunization, DHTR with sickle cell disease (SCD). Transfusions can lead to erythrocyte alloimmunization, however, with serious

Boyer, Edmond

430

Randomized Trial of Posaconazole and Benznidazole for Chronic Chagas' Disease  

Science Journals Connector (OSTI)

...partially susceptible T. cruzi strains, whereas only 76% were cured with benznidazole. In the model of chronic Chagas' disease, the differences were even greater: posaconazole was associated with cure rates of up to 60% in animals infected with susceptible and partially susceptible T. cruzi strains, whereas... There are limited treatment options for Trypanosoma cruzei infection, or Chagas' disease. Preclinical data had suggested that posaconazole might be an effective therapy. In this randomized trial, posaconazole monotherapy was found not to be effective.

Molina I.; Gómez i Prat J.; Salvador F.

2014-05-15T23:59:59.000Z

431

Effects of Vaccination on Invasive Pneumococcal Disease in South Africa  

Science Journals Connector (OSTI)

...through December 2012. Duplicate isolates cultured within 21 days after the initial positive culture were excluded. Serotyping and Susceptibility Testing. Pneumococci were serotyped with the use of the quellung reaction (Statens Serum Institut). Serotype 6C was distinguished from 6A throughout. We determined... Invasive pneumococcal disease is an important cause of severe illness. In South Africa, a national program to vaccinate children with the conjugated pneumococcal vaccine resulted in a substantial decline in invasive pneumococcal disease countrywide, including in adults.

von Gottberg A.; de Gouveia L.; Tempia S.

2014-11-13T23:59:59.000Z

432

Global Health: Behavioral and Dietary Risk Factors for Noncommunicable Diseases  

Science Journals Connector (OSTI)

...affected population health in the past or how they may do so in the future. In this article, we summarize the available data on trends in selected behavioral and dietary risk factors for noncommunicable diseases and examine the effects they have had, or may have in the future, on the health of populations... This review in the Global Health series focuses on the role of smoking, alcohol, and obesity in the burden of noncommunicable disease.

Ezzati M.; Riboli E.

2013-09-05T23:59:59.000Z

433

When Diseases Disappear — The Case of Familial Dysautonomia  

Science Journals Connector (OSTI)

...dysautonomia disappears, the historian Susan Lindee notes, a series of social and technological innovations will have made an invisible disease visible and then invisible once more. But it would be wrong to dismiss the condition as a 60-year-old problem that modern medicine eventually "fixed." For... The incidence of familial dysautonomia has decreased precipitously since population screening began in 2001. Dr. Barron Lerner writes that the potential disappearance of new cases of a disease raises profound questions.

Lerner B.H.

2009-10-22T23:59:59.000Z

434

Effect of Insulators on the Expression of betaAS3 in Lentiviral Gene Therapy for Sickle Cell Disease  

E-Print Network [OSTI]

al. (2001). Correction of sickle cell disease in transgenicto human bone marrow for sickle cell disease. Journal ofal. (2011). Correction of sickle cell disease in adult mice

Wherley, Jennifer Patricia

2013-01-01T23:59:59.000Z

435

E-Print Network 3.0 - agents causing diseases Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

disease is an inflammatory disease caused by a bacterium transmitted by ticks (small bloodsucking... that scientists think may transmit Ebola, a usually fatal ... Source:...

436

E-Print Network 3.0 - asymptomatic gallstone disease Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

-ray confirmed Graves' DiseaseHyperthyroidism Hypothyroidism Thyroid nodule (benign) Gout SLE (systemic lupus... other benign breast disease Confirmed by breast biopsy?...

437

E-Print Network 3.0 - atypical vogt-koyanagi-harada disease Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

differences in size, form, flower, fruit, foliage, and disease resistant... in the trade; these vary greatly in their aesthetic, size and shape, and disease resistance...

438

E-Print Network 3.0 - atypical kawasaki disease Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

differences in size, form, flower, fruit, foliage, and disease resistant... in the trade; these vary greatly in their aesthetic, size and shape, and disease resistance...

439

E-Print Network 3.0 - acalculous gallbladder disease Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

disease", and is in the OBO namespace mixed disease ontology. It is ... Source: Shapiro, Stuart C. - Department of Computer Science and Engineering, State University of...

440

E-Print Network 3.0 - alveolar hydatid disease Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Hydatid disease (echinococcosis) is due to infestation with cysts (metacestodes... . Poulin The Veterinary Journal 184 (2010) 9-13 12;hydatid disease may be more vulnerable to...

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

E-Print Network 3.0 - allergic lung disease Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

64 years of age who has a long- term health problem such as: heart disease lung disease sickle cell... Statements are available in Spanish and other languages. See...

442

E-Print Network 3.0 - animal disease outbreaks Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sample search results for: animal disease outbreaks Page: << < 1 2 3 4 5 > >> 1 Economic Consideration of Mitigation of Foreign Animal Disease Introduction * Summary:...

443

E-Print Network 3.0 - addison disease Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and the Transmission of Infectious Diseases Summary: Tropical Environments, Human Activities, and the Transmission of Infectious Diseases LISA... host-pathogen interactions;...

444

E-Print Network 3.0 - atherosclerotic heart disease Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

heart disease Search Powered by Explorit Topic List Advanced Search Sample search results for: atherosclerotic heart disease Page: << < 1 2 3 4 5 > >> 1 Stent's unique nature may...

445

E-Print Network 3.0 - acute diarrheal disease Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

fever Diarrheal disease caused by a parasite... Human Transport of Disease SARS The Cough Heard Round the World Severe ... Source: Otter, Ryan R. - Department of Biology,...

446

E-Print Network 3.0 - activity disease characteristics Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of the summer. Symptoms and Disease Characteristics From a distance, the symptoms... Patch Necrotic Ring Spot Rhizoctonia Large Patch Yellow Patch Turfgrass Disease Profiles...

447

E-Print Network 3.0 - anthracnose disease caused Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Ecology 35 Turfgrass Disease Profiles Purdue extension Summary: that cause brown patch and the Rhizoctonia large patch of zoysia grass (for more on these diseases, see......

448

Rheumatic Heart Disease and Beta-hemolytic Streptococci in Salvador, Brazil: A Study of Slum Health  

E-Print Network [OSTI]

rheumatic fever and rheumatic heart disease in Africa. S Afrthe chain that links the heart to the throat? Lancet Infectchildren with rheumatic heart disease. J Thorac Cardiovasc

Tartof, Sara Yee

2010-01-01T23:59:59.000Z

449

Chapter 18 - Epigenetic Aberrations in Human Allergic Diseases  

Science Journals Connector (OSTI)

The epidemic rise in childhood allergic diseases is clear evidence that the developing immune system is highly vulnerable to modern environmental change. Together with observed presymptomatic differences in immune functions at birth, this suggests that environmental exposures during pregnancy are critical in determining the allergic risk of the offspring. A range of intrauterine exposures such as maternal dietary factors, exposure to microbes, pollutants, and maternal smoking are implicated in fetal immune programming and the risk of allergic diseases. Concepts of epigenetic modulation of gene expression now provide a mechanistic link for these complex early gene–environmental interactions which appear to alter subsequent disease predisposition and potential heritability of disease risk across generations. As such, epigenetic changes provide a novel framework to explain the exponential rise in the prevalence of allergic diseases and other immune disorders within several generations. This is now supported by preliminary evidence that specific intrauterine exposures are associated with epigenetic changes in the expression of genes linked with either immune programming or an allergic phenotype in the offspring. Moreover, there are now examples of how these specific epigenetic effects can be passed on to subsequent generations. This new frontier provides not only novel insights into the understanding of complex immune diseases but also offers new opportunities to explore environmental strategies that can curb or even reverse the allergy epidemic through safe and effective reprogramming of gene expression during early development. While this possibility might now only appear as a distant horizon, the inherent epigenetic plasticity and observed capacity for intergenerational changes in disease predisposition offer great hope.

Manori Amarasekera; David Martino; Meri K. Tulic; Richard Saffery; Susan Prescott

2012-01-01T23:59:59.000Z

450

OSTI, US Dept of Energy, Office of Scientific and Technical Information |  

Office of Scientific and Technical Information (OSTI)

Data Leads to Progress Data Leads to Progress by Nena Moss on Thu, 19 Aug, 2010 My mother died in March 2010 after a 15-year battle with Alzheimer's, so I pay particular attention to news about this dreadful disease. A recent New York Times article caught my eye: "Sharing of Data Leads to Progress on Alzheimer's." How did sharing data lead to progress on Alzheimer's? A collaborative effort, the Alzheimer's Disease Neuroimaging Initiative, was formed to find the biological markers that show the progression of Alzheimer's disease in the human brain. The key was to share all the data, making every finding public immediately - "available to anyone with a computer anywhere in the world." Alzheimer's research is an enormous task with limited returns. Dr. Michael W. Weiner of the San Francisco Department of Veterans Affairs said

451

Bush Administration to Expand Beryllium Disease Screening Program |  

Broader source: Energy.gov (indexed) [DOE]

Bush Administration to Expand Beryllium Disease Screening Program Bush Administration to Expand Beryllium Disease Screening Program Bush Administration to Expand Beryllium Disease Screening Program February 23, 2005 - 10:27am Addthis Former employees of DOE vendors eligible for free screening WASHINGTON, DC - U.S. Secretary of Energy Samuel W. Bodman today announced the Department of Energy (DOE) will expand a beryllium screening program to include former employees of now-defunct DOE beryllium vendor companies across the country. Beryllium is a component used in nuclear weapons built by the Department of Energy. "Through no fault of their own, these Cold Warriors were left out in the cold when their former employers went out of business. By expanding this screening program, President Bush and the Department of Energy honor these

452

Title 10 CFR Part 850, Chronic Beryllium Disease Prevention Program  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Wednesday Wednesday December 8, 1999 Part III Department of Energy 10 CFR Part 850 Chronic Beryllium Disease Prevention Program; Final Rule VerDate 29-OCT-99 10:58 Dec 07, 1999 Jkt 190000 PO 00000 Frm 00001 Fmt 4717 Sfmt 4717 E:\FR\FM\A08DE0.189 pfrm04 PsN: 08DER3 68854 Federal Register / Vol. 64, No. 235 / Wednesday, December 8, 1999 / Rules and Regulations DEPARTMENT OF ENERGY 10 CFR Part 850 [Docket No. EH-RM-98-BRYLM] RIN 1901-AA75 Chronic Beryllium Disease Prevention Program AGENCY: Office of Environment, Safety and Health, Department of Energy. ACTION: Final rule. SUMMARY: The Department of Energy (DOE) is today publishing a final rule to establish a chronic beryllium disease prevention program (CBDPP) to reduce the number of workers currently exposed to beryllium in the course of their work at DOE facilities managed by

453

Laser mass spectrometry for DNA sequencing, disease diagnosis, and fingerprinting  

SciTech Connect (OSTI)

Since laser mass spectrometry has the potential for achieving very fast DNA analysis, the authors recently applied it to DNA sequencing, DNA typing for fingerprinting, and DNA screening for disease diagnosis. Two different approaches for sequencing DNA have been successfully demonstrated. One is to sequence DNA with DNA ladders produced from Snager`s enzymatic method. The other is to do direct sequencing without DNA ladders. The need for quick DNA typing for identification purposes is critical for forensic application. The preliminary results indicate laser mass spectrometry can possibly be used for rapid DNA fingerprinting applications at a much lower cost than gel electrophoresis. Population screening for certain genetic disease can be a very efficient step to reducing medical costs through prevention. Since laser mass spectrometry can provide very fast DNA analysis, the authors applied laser mass spectrometry to disease diagnosis. Clinical samples with both base deletion and point mutation have been tested with complete success.

Winston Chen, C.H.; Taranenko, N.I.; Zhu, Y.F.; Chung, C.N.; Allman, S.L.

1997-03-01T23:59:59.000Z

454

Investigation of saliva of patients with periodontal disease using NAA  

SciTech Connect (OSTI)

In this study the non-stimulated whole saliva of 26 healthy subjects (mean age 33.9 {+-} 11.0 years, range: 26 to 49 years) and 11 patients with periodontal disease (mean age 41.7 {+-} 11.5 years; range 29 to 55 years) was investigated using Neutron Activation Analysis (NAA) technique. The samples were obtained from donors at Sao Paulo city (Brazil). The analyses were performed in the nuclear reactor IEA-R1 (3.5-4.5MW, pool type) at IPEN/CNEN-SP (Brazil). Considerable changes in Ca and S saliva's level were identified in patients with periodontal disease suggesting they can be used as monitors of periodontal diseases.

Zamboni, C. B.; Metairon, S.; Medeiros, I. M. M. A. [Instituto de Pesquisas Energeticas e Nucleares, IPEN - CNEN/SP Av. Professor Lineu Prestes 2242- 05508-000 Sao Paulo, SP (Brazil); Lewgoy, H. R. [Universidade Anhanguera Bandeirante, UNIBAN R. Maria Candida, 1813, Bloco G / 6o andar - 02071-013 Sao Paulo, SP (Brazil)

2013-05-06T23:59:59.000Z

455

Fungus Threatens the Viability of Cotton For more than a century, the fungal disease cotton root  

E-Print Network [OSTI]

Fungus Threatens the Viability of Cotton For more than a century, the fungal disease cotton root rot has been one of the most destructive cotton diseases in Texas. Cotton root rot reduces yield. With the disease essentially eliminating harvestable cotton on affected acres, economic losses from the disease

456

CytoCom: a Cytoscape app to visualize, query and analyse disease comorbidity networks  

Science Journals Connector (OSTI)

......that can be used to search, explore, analyse...disease-disease associations in terms of bipartite graphs...uk 1 Introduction The term comorbidity refers to...disease, user needs to enter the seed disease code in the search box; CytoCom makes......

Mohammad Ali Moni; Haoming Xu; Pietro Liò

2014-12-01T23:59:59.000Z

457

Seamless Correction of the Sickle Cell Disease Mutation of the HBB Gene in Human Induced  

E-Print Network [OSTI]

Seamless Correction of the Sickle Cell Disease Mutation of the HBB Gene in Human Induced ABSTRACT: Sickle cell disease (SCD) is the most common human genetic disease which is caused by a single effector nucleases; induced pluripotent stem cells; piggyBac transposon; sickle cell disease; gene therapy

Zhao, Huimin

458

Immunosuppression by N-Methyl-d-Aspartate Receptor Antagonists Is Mediated through Inhibition of Kv1.3 and KCa3.1 Channels in T Cells  

Science Journals Connector (OSTI)

...and the NMDAR open-channel blocker memantine is used to treat Alzheimer's disease...noncompetitive open-channel blockers MK801 and memantine (5). These pharmaceuticals have been...experimental autoimmune encephalomyelitis, and memantine is used to treat Alzheimer's disease...

Sascha Kahlfuß; Narasimhulu Simma; Judith Mankiewicz; Tanima Bose; Theresa Lowinus; Stefan Klein-Hessling; Rolf Sprengel; Burkhart Schraven; Martin Heine; Ursula Bommhardt

2013-12-16T23:59:59.000Z

459

Disordered binding of small molecules to A12-28 DISORDERED BINDING OF SMALL MOLECULES TO A12-28  

E-Print Network [OSTI]

.vitalis@bioc.uzh.ch. Keywords: Alzheimer's disease; intrinsically disordered proteins; molecular dynamics; protein aggregation of Alzheimer's amyloid- protein in subtle but complex fashion. Conclusion: Intrinsic disorder of diseaseDisordered binding of small molecules to A12-28 DISORDERED BINDING OF SMALL MOLECULES TO A12

Caflisch, Amedeo

460

Chapter 104 - Sphingolipid Disorders and the Neuronal Ceroid Lipofuscinoses or Batten Disease (Wolman Disease, Cholesteryl Ester Storage Disease, and Cerebrotendinous Xanthomatosis)  

Science Journals Connector (OSTI)

This article is a revision of the previous edition article by Rose-Mary Boustany, Talal Mousallem, volume 3, pp 2449–2485, © 2007, Elsevier Ltd. Advances have been made in the sphingolipidoses and the many forms of Batten disease. Defects in sphingolipid synthetic enzymes and new Batten genes are identified. There is improved understanding of genetic diseases. Enzyme replacement/substrate reduction therapy are proving beneficial. Chaperones raise residual enzyme activities. Drugs affecting biochemical processes are emerging. Presymptomatic bone marrow replacement benefits certain sphingolipidoses. Viral gene therapies are encouraging in animal models Neural/non-neural stem cell therapies are under study. Efficient enzyme delivery into brain of animals/humans is being developed. These novel interventions are imperfect, and medicine is complex. Screening programs/genetic counseling/prenatal diagnosis remain the mainstays of prevention.

Rose-Mary Boustany; Ibraheem Al-Shareef; Sariah El-Haddad

2013-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

LLNL Chronic Beryllium Disease Protection Program Effectiveness Review, March 2011  

Broader source: Energy.gov (indexed) [DOE]

LLNL-2011-03-25 LLNL-2011-03-25 Site: Lawrence Livermore National Laboratory Subject: Office of Enforcement and Oversight's Office of Safety and Emergency Management Evaluations Activity Report for the Lawrence Livermore National Laboratory Chronic Beryllium Disease Prevention Program Effectiveness Review Dates of Activity : 03/14/2011 - 03/25/2011 Report Preparer: Marvin Mielke Activity Description/Purpose: The Lawrence Livermore National Laboratory (LLNL) and the Livermore Site Office (LSO) chartered a team to conduct an effectiveness review of the issues identified with the LLNL Chronic Beryllium Disease Prevention Program (CBDPP). The team included members and observers from LLNL, LSO, the National Nuclear Security Administration (NNSA), and the

462

A Test for Creutzfeldt–Jakob Disease Using Nasal Brushings  

Science Journals Connector (OSTI)

...issue) concluded that real-time shaking-induced conversion (RT-QuIC) testing of olfactory mucosa samples from patients with suspected Creutzfeldt–Jakob disease is highly sensitive and specific, as compared with a similar test of cerebrospinal fluid samples. But Table 1 of the article shows that the... To the Editor: In their study, Orrú et al. (Aug. 7 issue)1 concluded that real-time shaking-induced conversion (RT-QuIC) testing of olfactory mucosa samples from patients with suspected Creutzfeldt–Jakob disease is highly sensitive and specific, as ...

2014-11-06T23:59:59.000Z

463

A Test for Creutzfeldt–Jakob Disease Using Nasal Brushings  

Science Journals Connector (OSTI)

A Test for Creutzfeldt–Jakob Disease Using Nasal Brushings Original Article, N Engl J Med 2014;371:519-529. In Table 1 (page 522), in the "Time between Clinical Onset and OM Brushing" column, the values given for Patient 6 and Patient 13 should have been 9.0 and 14.0, respectively, rather than ?9... A Test for Creutzfeldt–Jakob Disease Using Nasal Brushings Original Article, N Engl J Med 2014;371:519-529. In Table 1 (page 522), in the “Time between Clinical Onset and OM Brushing” column, the values given for Patient 6 and Patient 13 should have been ...

2014-11-06T23:59:59.000Z

464

Compositions and Methods for the Treatment of Pierce's Disease  

DOE Patents [OSTI]

Chimeric anti-microbial proteins, compositions, and methods for the therapeutic and prophylactic treatment of plant diseases caused by the bacterial pathogen Xylella fastidiosa are provided. The anti-microbial proteins of the invention generally comprise a surface recognition domain polypeptide, capable of binding to a bacterial membrane component, fused to a bacterial lysis domain polypeptide, capable of affecting lysis or rupture of the bacterial membrane, typically via a fused polypeptide linker. In particular, methods and compositions for the treatment or prevention of Pierce's disease of grapevines are provided. Methods for the generation of transgenic Vitus vinefera plants expressing xylem-secreted anti-microbial chimeras are also provided.

Gupta, Goutam (Santa Fe, NM)

2008-10-07T23:59:59.000Z

465

Ebola Virus Disease in the Democratic Republic of Congo  

Science Journals Connector (OSTI)

...EVD and had an epidemiologic link to a confirmed case but was not tested and did not have laboratory confirmation of the disease. A probable or suspected case was classified as confirmed when a sample from the affected person tested positive for EBOV in the laboratory. In this study, the final classification... On August 24, 2014, when the eyes of the world were on the spreading West African outbreak of Ebola virus disease (EVD), the World Health Organization (WHO) was notified of another EVD outbreak in the vicinity of Boende town, Équateur province, in western ...

2014-10-15T23:59:59.000Z

466

Fruit and Nut Disease Control Products for Use in Texas  

E-Print Network [OSTI]

and/or distributors Contents 3 Fruit and Nut Disease Control PRODUCTS FOR USE IN TEXAS By George L.Philley* his listing of chemicals to control fruit diseases is a reference for county Extension agents and fruit producers in Texas... interval in days DF ?dry flowable F ?flowable L?liquid WDG ?wettable dispersable granule WG ?wettable granule WP?wettable powder days. Example: 7* indicates a 7-day interval from last application to har- vest. At the end of the publication is a listing...

Philley, George L.

2004-02-23T23:59:59.000Z

467

Ebola Virus Disease in West Africa — Clinical Manifestations and Management  

Science Journals Connector (OSTI)

...testing positive for Ebola virus in blood by polymerase chain reaction (PCR). Although some patients tested positive on PCR within 24 hours after symptom onset, we found that a negative test result could not be relied on to rule out disease until 72 hours after symptoms began. Of the patients who tested... In resource-limited areas, isolation of the sick from the population at large has been the cornerstone of control of Ebola virus disease (EVD) since the virus was discovered in 1976.1 Although this strategy by itself may be effective in controlling small ...

2014-11-05T23:59:59.000Z

468

LLNL Chronic Beryllium Disease Protection Program Effectiveness Review, March 2011  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

LLNL-2011-03-25 LLNL-2011-03-25 Site: Lawrence Livermore National Laboratory Subject: Office of Enforcement and Oversight's Office of Safety and Emergency Management Evaluations Activity Report for the Lawrence Livermore National Laboratory Chronic Beryllium Disease Prevention Program Effectiveness Review Dates of Activity : 03/14/2011 - 03/25/2011 Report Preparer: Marvin Mielke Activity Description/Purpose: The Lawrence Livermore National Laboratory (LLNL) and the Livermore Site Office (LSO) chartered a team to conduct an effectiveness review of the issues identified with the LLNL Chronic Beryllium Disease Prevention Program (CBDPP). The team included members and observers from LLNL, LSO, the National Nuclear Security Administration (NNSA), and the

469

Disease pathways at the Rat Genome Database Pathway Portal: genes in context—a network approach to understanding the molecular mechanisms of disease  

Science Journals Connector (OSTI)

A new resource offering a range of pathway data and visualization, including disease pathways and related pathway suites.

Victoria Petri; G Hayman; Marek Tutaj; Jennifer R Smith; Stanley Laulederkind; Shur-Jen Wang; Rajni Nigam; Jeff De Pons; Mary Shimoyama; Melinda R Dwinell; Elizabeth A Worthey; Howard J Jacob

2014-09-30T23:59:59.000Z

470

Comparing disease expression across species: an examination of radiation and species specific disease expression in Mus musculus and Peromyscus leucopus  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

disease expression across species: an examination of radiation and species specific disease expression across species: an examination of radiation and species specific disease expression in Mus musculus and Peromyscus leucopus William Liu 1 , Benjamin Haley 1 , Mary J. Kwasny 2 , Tatjana Paunesku 1 , Gayle Woloschak 1 1. Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2. Department of Preventative Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 From 1969 to 1992, the Janus program at Argonne National Laboratory performed a large series of radiobiology experiments, examining the effects of varying doses of neutron and gamma radiation on two disparate species of mice, Mus musculus and Peromyscus leucopus. Much of this data has since been digitized and made freely accessible online. This study aims to revisit

471

Cancer is a genetic disease1 . Although environmental  

E-Print Network [OSTI]

Cancer is a genetic disease1 . Although environmental and other non-genetic factors have roles in many stages of tumorigenesis,it is widely accepted that cancer arises because of mutations in cancer,however,does not suffice to give rise to full-blown cancer.For progression towards malignancyandinvasion

Nowak, Martin A.

472

Disease invasion: impacts on biodiversity and human health  

Science Journals Connector (OSTI)

...syndrome, bird flu and swine flu, and the revision...either a disease outbreak that dies out...within-host models a viable exercise...and analytical models of the dynamics...identify and predict future threats...the rinderpest outbreak in nineteenth...

2012-01-01T23:59:59.000Z

473

Effects of Global Climate on Infectious Disease: the Cholera Model  

Science Journals Connector (OSTI)

...impossible to predict precisely the...building predictive models for disease...events and cholera outbreaks have been increasing...Bangladesh, cholera outbreaks are related to...the nonlinear models, and interannual...variability of cholera outbreaks (124). Because...to use ENSO to predict variability in...

Erin K. Lipp; Anwar Huq; Rita R. Colwell

2002-10-01T23:59:59.000Z

474

A Global Perspective on Hantavirus Ecology, Epidemiology, and Disease  

Science Journals Connector (OSTI)

...unpredictable HPS outbreaks. In the Americas...the southwest, outbreaks of HPS cases have...been sufficient to predict the spatiotemporal...and ecological models should incorporate...threshold for disease outbreaks (23, 442a, 446...multispecies SIR-type models suggests possible...

Colleen B. Jonsson; Luiz Tadeu Moraes Figueiredo; Olli Vapalahti

2010-04-01T23:59:59.000Z

475

Factors that make an infectious disease outbreak controllable  

Science Journals Connector (OSTI)

...infectious disease outbreak dynamics that...8). This model can be used...that can help predict whether simple...stage of an outbreak. In our analyses...low variance model is appropriate...data from an outbreak of the 1978 H1N1 flu in a boys boarding...

Christophe Fraser; Steven Riley; Roy M. Anderson; Neil M. Ferguson

2004-01-01T23:59:59.000Z

476

Towards Understanding Global Spread of Disease from Everyday Interpersonal Interactions  

E-Print Network [OSTI]

spread of disease. We consider the important task of predicting the prevalence of flu- like illness into the mechanisms of dis- ease spread and significantly improve predictabil- ity of future flu outbreaks. Our media--places em- phasis on predicting which specific individuals will become afflicted with flu

Kautz, Henry

477

Tropical Environments, Human Activities, and the Transmission of Infectious Diseases  

E-Print Network [OSTI]

of water sources. The transmission of cholera, a water-borne disease, is related to sanitation practices decades as a consequence of large-scale agricultural development projects that have shifted the nature and quantity of water sources and potential mosquito breeding sites. Dracunculiasis is transmitted by a small

Gottgens, Hans

478

Infectious disease agents mediate interaction in food webs and ecosystems  

Science Journals Connector (OSTI)

...disease agents mediate interaction in food webs and ecosystems Sanja Selakovic 1 Peter...Netherlands Infectious agents are part of food webs and ecosystems via the relationship with...interactions, infectious agents influence food webs in terms of structure, functioning and...

2014-01-01T23:59:59.000Z

479

VECTOR BORNE AND ZOONOTIC DISEASES Volume 2, Number 2, 2002  

E-Print Network [OSTI]

-to-first-appearance in the eastern town- ships of Connecticut by ~29.7% (spread was from west to east). TSA revealed a similar effect the effect of local, spatially distributed environmental heterogeneities on disease spread. Using the time-to-town- ship transmission rate using Trend Surface Analysis (TSA) and then compared these estimates with those

Long, Andy

480

The Consequence of Tree Pests and Diseases for Ecosystem Services  

Science Journals Connector (OSTI)

...caterpillar as the cause of an epidemic airborne disease: Survey and analysis . Br. J. Dermatol. 149 , 990 ( 2003...across spatial scales among forest dieback, fire, and erosion in northern New Mexico...large areas of dead pine stands present a fire hazard and there...

I. L. Boyd; P. H. Freer-Smith; C. A. Gilligan; H. C. J. Godfray

2013-11-15T23:59:59.000Z

Note: This page contains sample records for the topic "alzheimer disease ada" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Fish oil can help reduce deaths from heart disease,  

E-Print Network [OSTI]

the risk of irregu- lar heart beats -- particularly in individuals with a recent heart attack. Paul CoatesFish oil can help reduce deaths from heart disease, according to new evidence reports announced evi- dence that long-chain omega- 3 fatty acids reduce heart at- tack and other problems, re- lated

Bandettini, Peter A.

482

PEBC Breast Cancer Disease Site Group page at:  

E-Print Network [OSTI]

Evidence-based Series 8-3 was reviewed in 2011 and ARCHIVED by the Melanoma Disease Site Group (DSG) on May 20, 2011. Evidence-based Series (EBS) 8-3 ARCHIVED 2011, the resulting review report, consists of the following 5 parts:

Program In Evidence-based Care (pebc; Cancer Care Ontario (cco

2011-01-01T23:59:59.000Z

483

Biological Agents and Infectious Diseases in War and Terrorism  

Science Journals Connector (OSTI)

War and the preparation for war cause serious damage to human health and the environment. Several biologic agents can be weaponized, but biologic weapons have been rarely used during war or in terrorist attacks. Of much greater concern is the increased occurrence of infectious diseases during war and its aftermath due to damage to medical care and public health facilities and the health-supporting infrastructure, forced migration of refugees and internally displaced persons, and diversion of human and financial resources. Although biologic weapons have almost never been used effectively in war and terrorism, they represent a potential threat. Biologic weapons are difficult to develop, access, and use in warfare or terrorist attacks. Nevertheless, it is important for health professionals and others to have an awareness of these potential weapons and what can be done to control them and prevent their use. Infectious diseases frequently increase in occurrence or severity during war and its aftermath. These include diarrheal diseases, acute respiratory infections, measles, malaria, meningococcal disease, and tuberculosis. Health professionals and others can play important roles in addressing these issues, by working to minimize the adverse consequences of war and terrorism and by helping to create a world without war and terrorism.

B.S. Levy; V.W. Sidel

2011-01-01T23:59:59.000Z

484

Intrinsically Disordered Proteins: Regulation and Disease Regulation of IDPs  

E-Print Network [OSTI]

31st Jan 2011 Intrinsically Disordered Proteins: Regulation and Disease Regulation of IDPs M. Madan ......................................................................................................................................8 #12;1 Abstract Intrinsically disordered proteins (IDPs) are often enriched in signaling and regulatory functions because the features of disordered segments permit interaction with multiple proteins

Babu, M. Madan

485

GUANYLATE CYCLASE-ACTIVATING PROTEINS AND RETINA DISEASE  

E-Print Network [OSTI]

in visual trans- duction that transcends to other neuronal Ca2+ homeostasis processes Keywords: Calcium, rod hyperpolarize. Open CNG 71 E. Carafoli and M. Brini (eds.), Calcium Signalling and Disease, 71­91. © 2007*, and PDE*). Deactivation of Figure 1. Negative cGMP/Ca2+ feedback loop. Light activates PDE which rapidly

Palczewski, Krzysztof

486

An approach for mining care trajectories for chronic diseases  

E-Print Network [OSTI]

An approach for mining care trajectories for chronic diseases Elias Egho1 ,Nicolas Jay1 , Chedy Ra of chronic patients. In this context, temporal data mining methods are promising tools, though lacking. We show the interest of our approach with the analysis of trajectories of care for colorectal cancer

Boyer, Edmond

487

PUBLICATION 600-080 Fish Health and Disease  

E-Print Network [OSTI]

PUBLICATION 600-080 Fish Health and Disease Striped bass (Morone saxitilis) and hybrid striped bass these fish are commonly raised in high densities under intensive aquaculture situations (e.g., cages, ponds of the viral, bacterial, fungal, and parasitic pathogens, but the fish become increasingly susceptible

Liskiewicz, Maciej

488

REVIEW ARTICLE Potato soil-borne diseases. A review  

E-Print Network [OSTI]

REVIEW ARTICLE Potato soil-borne diseases. A review Marie Fiers & Véronique Edel /Published online: 24 June 2011 # INRA and Springer Science+Business Media B.V. 2011 Abstract Potato crop potato and cause severe damages especially on tubers, the economically most impor- tant part of the plant

Paris-Sud XI, Université de

489

The smallpox story: life and death of an old disease.  

Science Journals Connector (OSTI)

...of the local smallpox surveillance team leader (total contact time during that ride...Administration of immune globulin did not change the course of the disease, and smallpox...Hardjotanojo. 1980. Residual skin changes in patients who have recovered from variola...

A M Behbehani

1983-12-01T23:59:59.000Z

490

Trypanosoma cruzi and Chagas' Disease in the United States  

Science Journals Connector (OSTI)

...S. , et al. 2008. Histopathological changes in the placentas and fetuses of mice infected...of the intergenic spacer of spliced-leader genes. Int. J. Parasitol. 40 :1599-1607...emerging diseases, 8th ed. W.B. Saunders Company, Philadelphia, PA. 177. Maguire...

Caryn Bern; Sonia Kjos; Michael J. Yabsley; Susan P. Montgomery

2011-10-01T23:59:59.000Z

491

Introduction The number of catalogued emerging infectious diseases (EIDs), and  

E-Print Network [OSTI]

to the emergence of infectious diseases include urbanization, human population growth, agricultural development of deforestation in parts of Africa are near 1% per year (FAO, 2009). Deforestation is also increasing in temperate with open spaces, have been correlated with increased anopheline mosquito densities (Yasuoka and Levins

Sehgal, Ravinder

492

IntroductionIntroduction Mercury: Monitoring Patients with ParkinsonMercury: Monitoring Patients with Parkinson''s Diseases Disease  

E-Print Network [OSTI]

IntroductionIntroduction Mercury: Monitoring Patients with ParkinsonMercury: Monitoring Patients's Disease EvaluationEvaluation Mercury ArchitectureMercury Architecture Mercury is a wireless sensor network and disconnections Node Behavior Hardware PlatformHardware Platform Usage Scenario InternetInternet http://fiji.eecs.harvard.edu/Mercury

Chen, Yiling

493

Effects of Chronic Nicotine Exposure and Lack of High Affinity Nicotinic Receptors on Cortico-Hippocampal Areas in the Aging Mouse Brain  

E-Print Network [OSTI]

performance. Epidemiology studies show that smoking is negatively correlated with the incidence of Parkinson's disease and Alzheimer's disease. Postmortem research and neuroimaging studies show that loss of nicotinic binding sites in the brain is the major...

Huang, Pei-San

2012-07-16T23:59:59.000Z

494

LANL spinoff receives NIH grant for respiratory disease diagnostic device  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

LANL spinoff receives NIH grant LANL spinoff receives NIH grant LANL spinoff receives NIH grant for respiratory disease diagnostic device Mesa Tech has been awarded a grant to develop an inexpensive, instrument-free, nucleic-acid testing device to diagnose various respiratory diseases in record time. October 19, 2011 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials. Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy

495

A 3-D Link between Antibiotic Resistance and Brain Disease  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

A 3-D Link between Antibiotic Resistance and Brain Disease A 3-D Link between Antibiotic Resistance and Brain Disease The story of what makes certain types of bacteria resistant to a specific antibiotic has a sub-plot that gives insight into the cause of a rare form of brain degeneration among children, according to investigators at St. Jude Children's Research Hospital. The story takes a twist as key differences among the structures of its main molecular characters disappear and reappear as they are assembled in the cell. The story is based on a study of the three-dimensional (3-D) structure of an enzyme called pantothenate kinase, which triggers the first step in the production coenzyme A (CoA), a molecule that is indispensable to all forms of life. Enzymes are proteins that speed up biochemical reactions. CoA plays a pivotal role in the cells' ability to extract energy from fatty

496

Mapping infectious disease landscapes: unmanned aerial vehicles and epidemiology  

Science Journals Connector (OSTI)

The potential applications of unmanned aerial vehicles (UAVs), or drones, have generated intense interest across many fields. \\{UAVs\\} offer the potential to collect detailed spatial information in real time at relatively low cost and are being used increasingly in conservation and ecological research. Within infectious disease epidemiology and public health research, \\{UAVs\\} can provide spatially and temporally accurate data critical to understanding the linkages between disease transmission and environmental factors. Using \\{UAVs\\} avoids many of the limitations associated with satellite data (e.g., long repeat times, cloud contamination, low spatial resolution). However, the practicalities of using \\{UAVs\\} for field research limit their use to specific applications and settings. \\{UAVs\\} fill a niche but do not replace existing remote-sensing methods.

Kimberly M. Fornace; Chris J. Drakeley; Timothy William; Fe Espino; Jonathan Cox

2014-01-01T23:59:59.000Z

497

Using Genomics to Study Human Biology and Disease  

SciTech Connect (OSTI)

The Human Genome Project culminated in April 2003 with the finished DNA sequence of all of the human chromosomes. This book of information, particularly in conjunction with the genome sequences of many other organisms, has already begun to revolutionize the way that biomedical scientists study our species. The identification of essentially all of our genes has provided a template upon which researchers can discover basic processes that govern cells, organs, and the whole organism, and to understand the fundamental causes of the diseases that occur when something goes wrong with a gene or a set of genes. The Genome Project has already made it possible to identify the genes that are defective in more than 1,000 rare inherited diseases, and these discoveries have helped to understand the mechanisms of the more common forms of these disorders. This understanding of primary defects in diseases - which is translated as mutations in genes that encode proteins that serve specific functions - is transforming the way that biotechnology and pharmaceutical companies identify drug targets, and a few notable cases have already had a striking impact on specific diseases. In addition, it has become clear that the differential response to drugs in human populations is heavily influenced by genes, and a whole field called pharmacogenetics has begun to identify these genetic factors. Such knowledge will allow physicians to prescribe drugs targeted to each individual, with the potential to increase efficacy and decrease side-effects. Determining the DNA sequence of the human genome and identifying the genes has been an exciting endeavor, but we are only just beginning to understand the treasures present in all of our DNA. My presentation will briefly describe the road we took to get the sequence, as well as the tools that we are developing to unlock its secrets.

Myers, Ricard M. (Stanford University School of Medicine) [Stanford University School of Medicine

2005-04-06T23:59:59.000Z

498

Spatial simulations of infectious disease: environment, behaviour, and their interaction in a primate population.  

E-Print Network [OSTI]

??Recent trends in emerging and re-emerging human infectious disease indicate that zoonotic diseases are on the rise (e.g., SARS, Swine Flu, Bird flu, Ebola, and… (more)

Bonnell, Tyler

2014-01-01T23:59:59.000Z

499

E-Print Network 3.0 - autoimmune demyelinating disease Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

NeuroVirology Summary: virus-induced demyelinating disease Jami L Bennett,1 Adam Elhofy,1 Mauro C Dal Canto,1 Mari Tani,2... , immune-mediated demyelinating disease (Miller et al,...

500

Ann Occup Hyg . Author manuscript Asbestos-related diseases in automobile mechanics  

E-Print Network [OSTI]

Ann Occup Hyg . Author manuscript Page /1 7 Asbestos-related diseases in automobile mechanics Abstract Purpose Automobile mechanics have been exposed to asbestos number of automobile mechanics, little is known about the non-malignant respiratory diseases observed

Paris-Sud XI, Université de