National Library of Energy BETA

Sample records for alzheimer disease ada

  1. Alzheimer's Disease and Vitamin E

    E-Print Network [OSTI]

    Empey, Matthew

    1998-01-01

    Adelman A. Selegiline and vitamin E in Alzheimer's disease.bomb. Geriatrics Traber MG. Vitamin E in humans: Demand andJ, Cole GM, Schubert D. Vitamin E protects nerve cells from

  2. New Clues in Predicting Alzheimer's Disease

    ScienceCinema (OSTI)

    Jagust, William

    2013-05-29

    Theres a new clue in the search to identify the harbingers of Alzheimers disease. More info: http://newscenter.lbl.gov/feature-stories/2008/12/16/predict-alzheimers-disease/

  3. Inflammation as a potential mediator for the association between periodontal disease and Alzheimer’s disease

    E-Print Network [OSTI]

    Watts, Amber; Crimmins, Eileen M.; Gatz, Margaret

    2008-09-10

    Periodontal disease (PDD) is associated with increased risk of cardiovascular disease, cerebrovascular disease, and mortality in many studies, while other studies have begun to suggest an association of PDD with Alzheimer’s disease (AD). This paper...

  4. Differential Network Analyses of Alzheimer’s Disease Identify Early Events in Alzheimer’s Disease Pathology

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Xia, Jing; Rocke, David M.; Perry, George; Ray, Monika

    2014-01-01

    In late-onset Alzheimer’s disease (AD), multiple brain regions are not affected simultaneously. Comparing the gene expression of the affected regions to identify the differences in the biological processes perturbed can lead to greater insight into AD pathogenesis and early characteristics. We identified differentially expressed (DE) genes from single cell microarray data of four AD affected brain regions: entorhinal cortex (EC), hippocampus (HIP), posterior cingulate cortex (PCC), and middle temporal gyrus (MTG). We organized the DE genes in the four brain regions into region-specific gene coexpression networks. Differential neighborhood analyses in the coexpression networks were performed to identify genes with lowmore »topological overlap (TO) of their direct neighbors. The low TO genes were used to characterize the biological differences between two regions. Our analyses show that increased oxidative stress, along with alterations in lipid metabolism in neurons, may be some of the very early events occurring in AD pathology. Cellular defense mechanisms try to intervene but fail, finally resulting in AD pathology as the disease progresses. Furthermore, disease annotation of the low TO genes in two independent protein interaction networks has resulted in association between cancer, diabetes, renal diseases, and cardiovascular diseases.« less

  5. Systematic review and meta-analysis of transgenic mouse models of Alzheimer’s disease 

    E-Print Network [OSTI]

    Egan, Kieren

    2014-07-05

    The increasing prevalence of Alzheimer’s disease poses a considerable socioeconomic challenge in the years ahead. There are few clinical treatments available and none capable of halting or slowing the progressive nature ...

  6. Functional Genomics of Brain Aging and Alzheimer’s Disease: Focus on Selective Neuronal Vulnerability

    E-Print Network [OSTI]

    Wang, Xinkun; Michaelis, Mary L.; Michaelis, Elias K.

    2010-10-21

    Pivotal brain functions, such as neurotransmission, cognition, and memory, decline with advancing age and, especially, in neurodegenerative conditions associated with aging, such as Alzheimer’s disease (AD). Yet, deterioration in structure...

  7. Why Do We Get Alzheimer's Disease?

    SciTech Connect (OSTI)

    Wyss-Coray, Tony (Stanford University) [Stanford University

    2006-01-02

    Neurodegenerative diseases and Alzheimer's disease (AD) in particular, are among the major health concerns of the elderly in industrialized societies. The cause of AD is unknown and no disease-modifying treatments are available. The disease is characterized clinically by a progressive dementia and pathologically by the accumulation of protein aggregates in the brain and a profound loss of nerve cells. It has also become clear recently that local immune responses are activated in the AD brain and may have a role in the disease. Our laboratory uses genetic mouse models to understand the disease process and to identify potential therapeutic targets.

  8. Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration.

    E-Print Network [OSTI]

    2007-01-01

    in Alzheimer’s disease causes neuronal death. FASEB J. 2001;Manuscript Figure 1. UbB + 1 causes neuritic beading andfound in Alzheimer’s disease causes neuritic beading of

  9. Social Cognition in Frontotemporal Dementia, Motor Neurone Disease, and Alzheimer's Disease 

    E-Print Network [OSTI]

    Oliver, Lindsay

    2011-11-23

    cognition across a number of neurodegenerative diseases, a test battery and two questionnaires were administered to frontal variant frontotemporal dementia (fvFTD), motor neurone disease (MND), Alzheimer`s disease, and healthy control participant groups...

  10. Identification of genetic influences in late-onset Alzheimer’s disease (LOAD) 

    E-Print Network [OSTI]

    Allen, Mariet

    2011-11-25

    Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia, with an incidence of up to 50% in western populations over the age of 85 and a high heritability (up to 80%). The identification of risk factors ...

  11. Motor signs predict poor outcomes in Alzheimer disease

    E-Print Network [OSTI]

    CME Motor signs predict poor outcomes in Alzheimer disease N. Scarmeas, MD; M. Albert, PhD; J--Objective: To examine whether the presence of motor signs has predictive value for important outcomes in Alzheimer months for a total of 3,149 visit-assessments, average 5.9 per patient), the presence of motor signs

  12. Multivariate and univariate neuroimaging biomarkers of Alzheimer's disease

    E-Print Network [OSTI]

    Multivariate and univariate neuroimaging biomarkers of Alzheimer's disease Christian Habeck January 2008 Available online 14 February 2008 We performed univariate and multivariate discriminant univariate and multivariate analyses produced markers with high classification accuracy in the derivation

  13. Neuroimaging of Discourse Processing in Aging and Alzheimer's Disease

    E-Print Network [OSTI]

    Wang, Clarice

    2011-12-31

    Detection of very early stages of Alzheimer's Disease (AD) has been an area of difficulty for researchers due to confounds with age. Prose recall has been suggested as a diagnostically sensitive test of episodic memory declines in AD; however...

  14. Motor signs during the course of Alzheimer disease

    E-Print Network [OSTI]

    to 13.1 years (mean 3.6 years) in five centers in Europe and the United States. MOSIs were rated using signs (MOSIs) are common in Alzheimer disease (AD) and may be associated with rates of cognitive decline a standardized portion of the Unified Parkinson's Disease Rating Scale. Overall, 3,030 visits

  15. Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla

    E-Print Network [OSTI]

    Thompson, Paul

    Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla and Alzheimer's disease based on high resolution MRI at 3 Tesla. T1-weighted images were acquired from 19

  16. Emotion Regulation Deficits in Frontotemporal Lobar Degeneration and Alzheimer's Disease

    E-Print Network [OSTI]

    Levenson, Robert W.

    Emotion Regulation Deficits in Frontotemporal Lobar Degeneration and Alzheimer's Disease Madeleine instructed and spontaneous emotion regulation in patients with frontotemporal lobar degeneration (FTLD, N 32) unwarned without instructions to down-regulate, (b) warned without instructions to down-regulate, and (c

  17. Learning Brain Connectivity of Alzheimer's Disease from Neuroimaging Data

    E-Print Network [OSTI]

    Li, Jing

    Learning Brain Connectivity of Alzheimer's Disease from Neuroimaging Data Shui Huang2 , Jing Li2 to alternation in the functional brain network, i.e., the functional connectivity among different brain regions. In this paper, we consider the problem of learning functional brain connectivity from neuroimaging, which holds

  18. Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy

    E-Print Network [OSTI]

    2009-01-01

    myocytes of leptomeningeal vessels. Acta Neuropathol 87:233–amyloid in the cortical vessel wall in Alzheimer’s disease.beta from neurons to vessels, contributing to amyloid

  19. Proteomic response to metabolic stress and cellular dysfunction in relation to Alzheimer's disease 

    E-Print Network [OSTI]

    Herrmann, Abigail Grace

    2014-06-28

    Vascular risk factors inducing a state of chronic cerebral hypoperfusion and metabolic stress are thought to influence the onset and progression of Alzheimer’s disease (AD). To investigate the complex molecular ...

  20. White matter integrity and visual short-term memory binding in familial Alzheimer's disease 

    E-Print Network [OSTI]

    Heikkila, Heini

    2011-11-23

    The asymptomatic phase of familial Alzheimer’s disease caused by E280A mutation in presenilin-1 gene is characterized by intact performance in traditional neuropsychological tasks including memory, language, and executive ...

  1. Ageing and Dual Task Ability - Development of a new test for Alzheimer's Disease 

    E-Print Network [OSTI]

    Young, Gregor

    2009-07-03

    Patients with Alzheimer’s disease (AD) display a specific deficit in the ability to perform dual tasks requiring working memory. This executive function deficit has been shown in a number of different research paradigms ...

  2. Personality traits distinguishing dementia with Lewy bodies from Alzheimer disease

    E-Print Network [OSTI]

    Galvin, James E.; Malcom, Heather; Johnson, David Kevin; Morris, John C.

    2007-05-29

    Personality traits distinguishing dementia with Lewy bodies from Alzheimer disease James E. Galvin, MD, MPH Heather Malcom David Johnson, PhD John C. Morris, MD ABSTRACT Objective: To identify personality traits that distinguish dementia with Lewy... and differentiation in conjunction with other DLB features. METHODS Research participants. Beginning in 1979, over 3,000 individuals have been enrolled in our longitudinal studies of healthy aging and dementia and over 800 of these participants have been studied...

  3. Oxidative Damage of DJ-1 Is Linked to Sporadic Parkinson and Alzheimer Diseases*

    E-Print Network [OSTI]

    Li, Lian

    Oxidative Damage of DJ-1 Is Linked to Sporadic Parkinson and Alzheimer Diseases* Received an autosomal recessive, early onset familial form of Parkinson disease (PD). However, little is presently known with sporadic PD and AD. Alzheimer disease (AD)2 and Parkinson disease (PD) are the two most common

  4. The impact of healthy ageing on dual task performance using a novel dual task paradigm: Implications for clinical use in Alzheimer’s disease

    E-Print Network [OSTI]

    Sotiriou, Sarah

    2011-06-29

    Abstract Primary objective: To explore the impact of healthy ageing on dual tasking abilities using a novel dual task paradigm and to consider any clinical implications in aiding the diagnosis of Alzheimer’s disease ...

  5. Oxidative Modifications and Aggregation of Cu,Zn-Superoxide Dismutase Associated with Alzheimer and Parkinson Diseases*

    E-Print Network [OSTI]

    Li, Lian

    and Parkinson Diseases* Received for publication, December 20, 2004, and in revised form, January 18, 2005 oxidative stress has been strongly impli- cated in the pathogenesis of Alzheimer disease (AD) and Parkinson(s) that could potentially be tar- geted by similar therapeutic strategies. Alzheimer disease (AD),1 Parkinson

  6. Iron and aluminum interaction with amyloid-beta peptides associated with Alzheimer’s disease

    SciTech Connect (OSTI)

    Drochioiu, Gabi; Ion, Laura; Murariu, Manuela; Habasescu, Laura

    2014-10-06

    An elevation in the concentration of heavy metal ions in Alzheimer’s disease (AD) brain has been demonstrated in many studies. A? precipitation and toxicity in AD brains seem to be caused by abnormal interactions with neocortical metal ions, especially iron, copper, zinc, and aluminum [1–3]. There is increasing evidence that iron and aluminum ions are involved in the mechanisms that underlie the neurodegenerative diseases [4,5]. However, evidence was brought to demonstrate that some A? fragments, at physiological pH, are not able to form binary complexes with Fe(III) ions of sufficient stability to compete with metal hydroxide precipitation [6]. On the contrary, multiple metal ions are known to interact with A? peptides [7]. Consequently, we investigated here the interaction of Fe(II/III) and Al(III) ions with some amyloid-? peptides and fragments that results in peptide aggregation and fibrillation [8,9]. Infrared spectroscopy, atomic force microscopy, scanning electron microscopy, electrophoresis and mass spectrometry demonstrated conformational changes of peptides in the presence of such metals.

  7. Analyzing and modeling the kinetics of amyloid beta pores associated with Alzheimer’s disease pathology

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Ullah, Ghanim; Demuro, Angelo; Parker, Ian; Pearson, John E.; Xu, Shang -Zhong

    2015-09-08

    Amyloid beta (A?) oligomers associated with Alzheimer’s disease (AD) form Ca2+-permeable plasma membrane pores, leading to a disruption of the otherwise well-controlled intracellular calcium (Ca2+) homeostasis. The resultant up-regulation of intracellular Ca2+ concentration has detrimental implications for memory formation and cell survival. The gating kinetics and Ca2+ permeability of A? pores are not well understood. We have used computational modeling in conjunction with the ability of optical patch-clamping for massively parallel imaging of Ca2+ flux through thousands of pores in the cell membrane of Xenopus oocytes to elucidate the kinetic properties of A? pores. The fluorescence time-series data from individualmore »pores were idealized and used to develop data-driven Markov chain models for the kinetics of the A? pore at different stages of its evolution. Our study provides the first demonstration of developing Markov chain models for ion channel gating that are driven by optical-patch clamp data with the advantage of experiments being performed under close to physiological conditions. As a result, we demonstrate the up-regulation of gating of various Ca2+ release channels due to A? pores and show that the extent and spatial range of such up-regulation increases as A? pores with low open probability and Ca2+ permeability transition into those with high open probability and Ca2+ permeability.« less

  8. Metabonomic Profiling of TASTPM Transgenic Alzheimer's Disease Mouse Model

    SciTech Connect (OSTI)

    Hu, Zeping; Browne, Edward R.; Liu, Tao; Angel, Thomas E.; Ho, Paul C.; Chun Yong Chan, Eric

    2012-12-07

    Identification of molecular mechanisms underlying early stage Alzheimer’s disease (AD) is important for the development of new therapies against and diagnosis of AD. In this study, non-targeted metabotyping of TASTPM transgenic AD mice was performed. The metabolic profiles of both brain and plasma of TASTPM mice were characterized using gas chromatography-mass spectrometry and compared to those of wild type C57BL/6J mice. TASTPM mice were metabolically distinct compared to wild type mice (Q28 Y = 0.587 and 0.766 for PLS-DA models derived from brain and plasma, respectively). A number of metabolites were found to be perturbed in TASTPM mice in both brain (D11 fructose, L-valine, L-serine, L-threonine, zymosterol) and plasma (D-glucose, D12 galactose, linoleic acid, arachidonic acid, palmitic acid and D-gluconic acid). In addition, enzyme immunoassay confirmed that selected endogenous steroids were significantly perturbed in brain (androstenedione and 17-OH-progesterone) and plasma (cortisol and testosterone) of TASTPM mice. Ingenuity pathway analysis revealed that perturbations related to amino acid metabolism (brain), steroid biosynthesis (brain), linoleic acid metabolism (plasma) and energy metabolism (plasma) accounted for the differentiation of TASTPM and wild-type

  9. Nanoimaging to Prevent and Treat Alzheimer’s and Parkinson’s Diseases. Scientific/Technical report

    SciTech Connect (OSTI)

    Yuri L. Lyubchenko, PhD, DSc

    2012-12-20

    This project will develop innovative approaches to characterization of the very early stages of protein aggregation that eventually can be translated to the development of early diagnostic tools and efficient treatments for Alzheimer’s, Parkinson’s and Huntington’s diseases. Funding will be used to acquire nanoimaging technology for nanoscale imaging, manipulation and analysis of biomedical materials to develop treatments that will repair disabled proteins and cure diseases that result from protein malfunction, specifically Alzheimer’s and Parkinson’s diseases. Expected outcomes include tests for early diagnosis and therapeutic treatments for these devastating neurological diseases. To elucidate the mechanisms of protein misfolding, we will establish an extensive program of experimental studies using a broad arsenal of advanced nanoscale and traditional techniques that will be integrated with molecular-scale modeling of protein misfolding and the nucleation of aggregate structures. To identify intracellular machinery or/and multicomponent complexes critically involved in protein misfolding, we will characterize interactions between targeted proteins and specific intracellular components or metabolites that impact on protein conformational pathways leading to protein misfolding accompanied by formation of toxic aggregated morphologies. To design innovative nanotechnology tools for the control of intracellular protein misfolding and aggregation processes, we will develop a predictive molecular scale model for intracellular protein misfolding and the formation of toxic aggregates. Verified through experimental studies, the objective is to establish an enabling foundation for the engineering of novel molecular diagnostics and therapeutics for various cellular pathologies.

  10. Multivariate Protein Signatures of Pre-Clinical Alzheimer's Disease in the Alzheimer's Disease Neuroimaging Initiative (ADNI) Plasma Proteome Dataset

    E-Print Network [OSTI]

    Johnstone, Daniel; Milward, Elizabeth A.; Berretta, Regina; Moscato, Pablo

    2012-01-01

    Multivariate Protein Signatures of Pre-Clinical Alzheimer’s= 2.3610 213 ). We applied a multivariate approach based onInitiative (2012) Multivariate Protein Signatures of Pre-

  11. Dual task performance in early Alzheimer's disease, amnestic mild cognitive impairment and depression 

    E-Print Network [OSTI]

    Tierney, K. M.; Lonie, J. A.; Donaghey, C.; Ebmeier, K. P.; Lee, A.; Herrmann, L. L.; O'Carroll, R. E.

    Background. The dual task paradigm (Baddeley et al. 1986; Della Sala et al. 1995) has been proposed as a sensitive measure of Alzheimer's dementia, early in the disease process. Method. We investigated this claim by ...

  12. Automated MRI measures identify individuals with mild cognitive impairment and Alzheimer's disease

    E-Print Network [OSTI]

    Desikan, Rahul S.

    Mild cognitive impairment can represent a transitional state between normal ageing and Alzheimer's disease. Non-invasive diagnostic methods are needed to identify mild cognitive impairment individuals for early therapeutic ...

  13. Review article Nutrition and Alzheimer's disease: The detrimental role of a high carbohydrate diet

    E-Print Network [OSTI]

    Seneff, Stephanie

    Review article Nutrition and Alzheimer's disease: The detrimental role of a high carbohydrate diet and Computer Science, MIT Cambridge, MA, USA b Independent Reader of Research, Leeds, United Kingdom c Comando

  14. Repurposing Drugs for Alzheimer's Disease and Related Dementias Request for Proposals (RFP)

    E-Print Network [OSTI]

    Charette, André

    Repurposing Drugs for Alzheimer's Disease and Related Dementias Request for Proposals (RFP) Neurodegenerative diseases represent one of the most difficult classes of diseases for which to develop drugs, yet, offering a huge opportunity to target some of these pathways with repurposed drugs approved

  15. Educational attainment and rate of cognitive decline in Alzheimer's disease 

    E-Print Network [OSTI]

    Hemmy, Laura Sue

    2009-05-15

    progressive neurodegenerative dementia at his or her most recent clinic visit, (2) had been seen in the GRECC Memory Loss Clinic and administered either the Mini-Mental State Exam (MMSE) on a minimum of three occasions or the Cognitive Performance Test (CPT... clinical database. Measures Mini-Mental State Exam. Cognitive decline was assessed using the Mini-Mental State Exam (MMSE; Folstein et al., 1975), a measure with both advantages and disadvantages in characterizing change in Alzheimer?s patients...

  16. Monte Carlo Simulation of Alzheimer's Disease in the United States: 2010-2060

    E-Print Network [OSTI]

    Feres, Renato

    Monte Carlo Simulation of Alzheimer's Disease in the United States: 2010-2060 Michael Blech concerns facing the United States over the next 50 years. This progressive disease is currently the sixth on the United States population, and second, the simulation models both prevalence and mortality. Both

  17. Aging is the primary risk factor for the majority of neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million

    E-Print Network [OSTI]

    Liu, Taosheng

    Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million people aged 65 and genetics that promote healthy aging will decrease the incidence of these diseases in the general populationAging is the primary risk factor for the majority of neurodegenerative diseases, including

  18. Aging is the primary risk factor for the majority of neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million

    E-Print Network [OSTI]

    Liu, Taosheng

    Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million people aged 65 and genetics that promote healthy aging will decrease the incidence of these diseases in the general population James Parkinson first described the clinical symptoms of Parkinson's disease (PD) in his 1817 monograph

  19. Aging is the primary risk factor for the majority of neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million

    E-Print Network [OSTI]

    Liu, Taosheng

    Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million people aged 65 and genetics that promote healthy aging will decrease the incidence of these diseases in the general population array of neurobiological disorders, including Parkinson's disease, epilepsy, essential tremor, Tourette

  20. Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease,

    E-Print Network [OSTI]

    Nyholt, Dale R.

    proportion of total variation tagged by all SNPs was 0.26 (SE 0.04) for ED, 0.24 (SE 0.03) for AD and 0 that a substantial proportion of variation in liability is explained by common SNPs, and thereby give insightsEstimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease

  1. Automated ventricular mapping with multi-atlas fluid image alignment reveals genetic effects in Alzheimer's disease

    E-Print Network [OSTI]

    Thompson, Paul

    in Alzheimer's disease Yi-Yu Chou,a Natasha Leporé,a Greig I. de Zubicaray,b Owen T. Carmichael,c James T. Becker,d Arthur W. Toga,a and Paul M. Thompsona, a Laboratory of Neuro Imaging, Department of Neurology

  2. VENTRICULAR MAPS IN 804 SUBJECTS CORRELATE WITH COGNITIVE DECLINE, CSF PATHOLOGY, AND IMMINENT ALZHEIMER'S DISEASE

    E-Print Network [OSTI]

    Thompson, Paul

    ALZHEIMER'S DISEASE Yi-Yu Chou1 , Natasha Leporé1 , Priya Saharan1 , Sarah K. Madsen1 , Xue Hua1 , Clifford R. Jack2 , Leslie M. Shaw3 , John Q. Trojanowski3 , Michael W. Weiner4 , Arthur W. Toga1 , Paul M

  3. DICOVERY OF "BIOMARKERS" FOR ALZHEIMER'S DISEASE PREDICTION FROM STRUCTURAL MR IMAGES

    E-Print Network [OSTI]

    DICOVERY OF "BIOMARKERS" FOR ALZHEIMER'S DISEASE PREDICTION FROM STRUCTURAL MR IMAGES Y. Liu1,2,3 , L. A. Teverovskiy2 , O. L. Lopez3 , H. Aizenstein3 , C. C. Meltzer3,4 , J. T. Becker3 1 Penn State discrimination using high-resolutionMagnetic Resonance (MR) brain images. We focus on the exploration of a very

  4. Changes in Painting Styles of Two Artists With Alzheimer's Disease Benjamin van Buren and Bianca Bromberger

    E-Print Network [OSTI]

    Chatterjee, Anjan

    Changes in Painting Styles of Two Artists With Alzheimer's Disease Benjamin van Buren and Bianca of literature supports the idea that systematic changes can occur in artists' painting styles after the onset, emotion, symbolism, realism, and animacy), we found that both AD patients produced paintings with more

  5. Identifying Alzheimers Disease-Related Brain Regions from Multi-Modality Neuroimaging Data

    E-Print Network [OSTI]

    Li, Jing

    1 Identifying Alzheimers Disease-Related Brain Regions from Multi-Modality Neuroimaging Data using sensitivity and specificity. The fast growing neuroimaging techniques hold great promise.8 Research so far has focused on single neuroimaging modalities. However, as different modalities9 provide complementary

  6. Will our final years be golden? Mortality by Alzheimer's disease in the United States 

    E-Print Network [OSTI]

    Davis, Mary Ann

    2007-09-17

    Alzheimer'Ã?Â?Ã?Â?s disease (AD) is the fifth leading cause of death among the elderly. This study uses National Center for Health Statistics (NCHS) Multiple Cause of Death data for the United States for the years 1998 to ...

  7. ADA Retrofit and Construction

    E-Print Network [OSTI]

    Minnesota, University of

    ADA Retrofit and Construction Management Richfield, MN Breckenridge, MN #12;Introduction & Outline Design vs. Construction § Case Studies § City of Richfield's Transition Plan #12;How Detailed Should, MN #12;Case Study Breckenridge, MN #12;§ Construction Plans § Intersection Details for "tough

  8. Motor signs predict poor outcomes in Alzheimer disease

    E-Print Network [OSTI]

    ) in five University-based AD centers in the United States and European Union. Four outcomes, assessed every index, and death. Using a standardized portion of the Unified PD Rating Scale (administered every 6 disease (AD). Methods: A total of 533 patients with AD at early stages (mean Folstein Mini-Mental State

  9. Parallel programming with Ada

    SciTech Connect (OSTI)

    Kok, J.

    1988-01-01

    To the human programmer the ease of coding distributed computing is highly dependent on the suitability of the employed programming language. But with a particular language it is also important whether the possibilities of one or more parallel architectures can efficiently be addressed by available language constructs. In this paper the possibilities are discussed of the high-level language Ada and in particular of its tasking concept as a descriptional tool for the design and implementation of numerical and other algorithms that allow execution of parts in parallel. Language tools are explained and their use for common applications is shown. Conclusions are drawn about the usefulness of several Ada concepts.

  10. Optimizing power to track brain degeneration in Alzheimer's disease and mild cognitive impairment with tensor-based morphometry

    E-Print Network [OSTI]

    Thompson, Paul

    . Leow a,b , Yi-Yu Chou a , April J. Ho a , Boris Gutman a , Arthur W. Toga a , Clifford R. Jack Jr d,j , Gene E. Alexander l , Michael W. Weiner i,j,k,l , Paul M. Thompson a, and the Alzheimer's Disease

  11. Alzheimer's Disease: NMR Studies of Asialo (GM1) and Trisialo (GT1b) Ganglioside Interactions with A (1-40)

    E-Print Network [OSTI]

    Mandal, Pravat K.

    447 Alzheimer's Disease: NMR Studies of Asialo (GM1) and Trisialo (GT1b) Ganglioside Interactions-like membranes composed of gangliosides. Ganglioside GM1 binds tightly with A and it is specu- lated that GM1 dodecyl sulphate (SDS) micelles, a membrane-mimicking environment. These studies reveal that asialoGM1

  12. What Do Family Caregivers of Alzheimer's Disease Patients Desire in Smart Home Technologies?

    E-Print Network [OSTI]

    Rialle, Vincent; Guigui, Carole; Hervé, Christian

    2009-01-01

    Objectives - The authors' aim was to investigate the representations, wishes, and fears of family caregivers (FCs) regarding 14 innovative technologies (IT) for care aiding and burden alleviation, given the severe physical and psychological stress induced by dementia care, and the very slow uptake of these technologies in our society. Methods - A cluster sample survey based on a self-administered questionnaire was carried out on data collected from 270 families of patients with Alzheimer's disease or related disorders, located in the greater Paris area. Multiple Correspondence Analysis was used in addition to usual statistical tests to identify homogenous FCs clusters concerning the appreciation or rejection of the considered technologies. Results - Two opposite clusters were clearly defined: FCs in favor of a substantial use of technology, and those rather or totally hostile. Furthermore the distributions of almost all the answers of appreciations were U shaped. Significant relations were demonstrated betwee...

  13. Key residues for the oligomerization of A{beta}42 protein in Alzheimer's disease

    SciTech Connect (OSTI)

    Ngo, Sam [Department of Neurology, Brain Research Institute, Molecular Biology Institute, University of California, Los Angeles, CA 90095 (United States)] [Department of Neurology, Brain Research Institute, Molecular Biology Institute, University of California, Los Angeles, CA 90095 (United States); Guo, Zhefeng, E-mail: zhefeng@ucla.edu [Department of Neurology, Brain Research Institute, Molecular Biology Institute, University of California, Los Angeles, CA 90095 (United States)] [Department of Neurology, Brain Research Institute, Molecular Biology Institute, University of California, Los Angeles, CA 90095 (United States)

    2011-10-28

    Highlights: Black-Right-Pointing-Pointer A{beta} oligomers are neurotoxins and likely the causing agents for Alzheimer's disease. Black-Right-Pointing-Pointer A{beta}42 fusion protein form globular oligomers. Black-Right-Pointing-Pointer A{beta}42 fusion protein oligomers contain SDS-resistant tetramers and hexamers. Black-Right-Pointing-Pointer Cysteine substitutions at residues 31, 32, 34, 39-41 disrupt A{beta}42 oligomerization. -- Abstract: Deposition of amyloid fibrils consisting of amyloid {beta} (A{beta}) protein as senile plaques in the brain is a pathological hallmark of Alzheimer's disease. However, a growing body of evidence shows that soluble A{beta} oligomers correlate better with dementia than fibrils, suggesting that A{beta} oligomers may be the primary toxic species. The structure and oligomerization mechanism of these A{beta} oligomers are crucial for developing effective therapeutics. Here we investigated the oligomerization of A{beta}42 in the context of a fusion protein containing GroES and ubiquitin fused to the N-terminus of A{beta} sequence. The presence of fusion protein partners, in combination with a denaturing buffer containing 8 M urea at pH 10, is unfavorable for A{beta}42 aggregation, thus allowing only the most stable structures to be observed. Transmission electron microscopy showed that A{beta}42 fusion protein formed globular oligomers, which bound weakly to thioflavin T and Congo red. SDS-PAGE shows that A{beta}42 fusion protein formed SDS-resistant hexamers and tetramers. In contrast, A{beta}40 fusion protein remained as monomers on SDS gel, suggesting that the oligomerization of A{beta}42 fusion protein is not due to the fusion protein partners. Cysteine scanning mutagenesis at 22 residue positions further revealed that single cysteine substitutions of the C-terminal hydrophobic residues (I31, I32, L34, V39, V40, and I41) led to disruption of hexamer and tetramer formation, suggesting that hydrophobic interactions between these residues are most critical for A{beta}42 oligomerization.

  14. DEVELOPMENT OF AUTOMATED SOFTWARE PROGRAM FOR THE ANALYSIS OF ALZHEIMER'S DISEASE BETA-AMYLOID SCANS

    SciTech Connect (OSTI)

    Mariotti, Jack; Zubal, George

    2013-12-18

    Study goal: A Phase 1 evaluation of the kinetics, clearance and cerebral distribution of one novel peripheral benzodiazepine receptors(PBR)positron emission tomography (PET) imaging agent, 18F-PBR-111 following intravenous administration in healthy volunteers and Alzheimer's disease (AD) patients. Short title: Evaluation of PET imaging with PBR-111 in HV and AD subjects Proof of Mechanism. Primary Objective: To evaluate the cerebral distribution of PBR-111 positron emission tomography (PET) for detection/exclusion of microglial activation in patients with Alzheimer's disease subjects compared to healthy volunteers. Secondary objectives: - To assess the dynamic uptake and washout of [18F]PBR-111, a potential imaging bio-marker for inflammatory changes in brain, using positron emission tomography in subjects with Alzheimer's disease (AD) and healthy volunteers (HV). - To perform blood metabolite characterization of [18F]PBR-111 in subjects with AD and HV to determine the nature of metabolites in assessment of [18F]-PBR-111 as a PET brain imaging agent. Name of radioactive drug substance: PBR-111 Dose(s): The applied PBR-111 radioactive dose will be up to 5.0 mCi, diluted in a maximum of 10 ml of saline. The radioligand will be administered as a slow intravenous bolus injection (i.e., 6 sec/ml) into a large vein (e.g., antecubital vein). Route of administration: Intravenous injection Duration of treatment: Single administration of a diagnostic agent Indication: PBR-111 positron emission tomography (PET) imaging has the potential to detect microglial activation. In the presence of PBR-111 uptake (representative of microglial activation), inflammation in the brain can be detected. Diagnosis and main criteria for inclusion: Study participants will be HVs and patients diagnosed with probable AD. HVs must be 18 years of age (at least four subjects 50 years of age) and have no evidence of cognitive impairment or other neurologic disease by medical history. The lack of cognitive impairment will also be based on a Clinical Dementia Rating (CDR) of 0. Patients with probable AD must be 50 years of age and must fulfill the National Institute of Neurological and Communicative Disorders and Stroke, Alzheimer's Disease and Related Disorders Association [NINCDS-ADRDA] criteria for probable AD. The CDR score must be 1.0 and 2.0 and have a modified Hachinski of 4. All HVs and all patients with probable AD must be able to comply with all study procedures. Study design: This is a Phase 1, open-label, single-center, non-randomized single dose study to assess the kinetics, clearance and cerebral distribution of PBR-111 PET imaging in detecting microglial activation in the brain in patients with probable AD compared to HVs. All aspects related to image acquisition, processing, and visual as well as quantitative evaluation will be developed, optimized, and validated (where required). Each subject will be required to visit the study center during the screening phase and on the PBR-111 PET imaging day (baseline). A telephone follow-up visit will be performed 7 days (± 3 days) after PBR-111 PET administration. At the screening visit, each subject (or caregiver in the case of AD subjects) will be asked to provide written informed consent or assent. During the screening phase (maximum duration of 60 days) subject medical, neurological, and surgical history, clinical assessments, and a neuro-psychiatric evaluation will be performed on all eligible subjects. Subjects will be allowed to leave the center after all evaluations have been completed. During this period an MRI of the brain will be performed during the screening period. If an MRI of the brain has been performed within six months of the imaging visit using the methods described in the protocol, and there has been no medically significant events in the interim, the previous MRI may be used. During the PBR-111 PET imaging day, all subjects will receive a single intravenous injection of PBR-111 and scanning will be performed over a 3.5 hour period. Each subject will have a telephone follow-up 7 da

  15. Neuronal networks with coupling through amyloid beta: towards a theory for Alzheimer's disease

    E-Print Network [OSTI]

    V. Resmi; G. Ambika; R. E. Amritkar; G. Rangarajan

    2010-11-18

    Alzheimer's disease (AD) is a common form of dementia observed in the elderly due to neurodegenerative disorder and dysfunction. This arises from alterations in synaptic functioning of neurons leading to cognitive impairment and memory loss. Recent experimental studies indicate that the amyloid beta (A beta) protein, in its dimer and oligomer forms, affects the synaptic activity of neurons in the early stages of AD. However, the precise mechanism underlying A beta induced synaptic depression is still not clearly understood. In this paper, we introduce an electrical model that provides a possible mechanism for this. Our studies show that the competing effects of synaptic activity and the indirect interaction mediated by A beta, can disrupt the synchrony among neurons and severely affect the neuronal activity. This then leads to sub-threshold activity or synaptic silencing. This is in agreement with the reported disruption of cortical synaptic integration in the presence of A beta in transgenic mice. We suggest that direct electrophysiological measurements of A beta activity can establish its role in AD and the possible revival, proposed in our model. The mechanism proposed here is quite general and could account for the role of the relevant protein in other neuronal disorders also.

  16. Multivariate Data Analysis for Neuroimaging Data: Overview and Application to Alzheimer's Disease

    E-Print Network [OSTI]

    REVIEW Multivariate Data Analysis for Neuroimaging Data: Overview and Application to Alzheimer for sophisticated neuroimaging analysis becomes more apparent. Multivariate analysis techniques have recently. Multivariate techniques also lend themselves much better to prospective application of results from

  17. with Disabilities Act Requirements Workplace ADA Requirements...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Americans with Disabilities Act (ADA) is a federal civil rights law that prohibits discrimination in public places against individuals with disabilities. As an employer installing...

  18. Fourier Transform Infrared Imaging Showing Reduced Unsaturated Lipid Content in the Hippocampus of a mouse Model of Alzheimer's Disease

    SciTech Connect (OSTI)

    Leskovjan, A.C.; Kretlow, A.; Miller, L.M.

    2010-04-01

    Polyunsaturated fatty acids are essential to brain functions such as membrane fluidity, signal transduction, and cell survival. It is also thought that low levels of unsaturated lipid in the brain may contribute to Alzheimer's disease (AD) risk or severity. However, it is not known how accumulation of unsaturated lipids is affected in different regions of the hippocampus, which is a central target of AD plaque pathology, during aging. In this study, we used Fourier transform infrared imaging (FTIRI) to visualize the unsaturated lipid content in specific regions of the hippocampus in the PSAPP mouse model of AD as a function of plaque formation. Specifically, the unsaturated lipid content was imaged using the olefinic {double_bond}CH stretching mode at 3012 cm{sup -1}. The axonal, dendritic, and somatic layers of the hippocampus were examined in the mice at 13, 24, 40, and 56 weeks old. Results showed that lipid unsaturation in the axonal layer was significantly increased with normal aging in control (CNT) mice (p < 0.01) but remained low and relatively constant in PSAPP mice. Thus, these findings indicate that unsaturated lipid content is reduced in hippocampal white matter during amyloid pathogenesis and that maintaining unsaturated lipid content early in the disease may be critical in avoiding progression of the disease.

  19. Grape-derived polyphenolics prevent A? oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease

    E-Print Network [OSTI]

    2008-01-01

    153:185–192. nisms of green tea polyphenols in Alzheimer’sGreen CE, Krafft GA, Klein WL (1998) Diffusible, nonfibrillar ligands derived tea

  20. Asset Management for ADA Compliance Using Advanced Technologies

    E-Print Network [OSTI]

    Bertini, Robert L.

    Asset Management for ADA Compliance Using Advanced Technologies Portland State University Center National Cooperative Highway Research Program (NCHRP), Asset Management Approaches to ADA Compliance, NCHRP

  1. Using yeast to study neurodegenerative diseases : amyloid formation as a protective mechanism and a new Alzheimer's disease model

    E-Print Network [OSTI]

    Treusch, Sebastian

    2011-01-01

    Numerous neurodegenerative diseases are pathologically characterized by idiosyncratic protein amyloid inclusions. Not surprisingly amyloid fibrils have long been proposed to be the toxic protein species in these neurodegenerative ...

  2. Measuring Dementia of the Alzheimer Type More Precisely 

    E-Print Network [OSTI]

    Lowe, Deborah Anne

    2012-11-29

    Alzheimer’s disease (AD) progressively impairs cognitive and functional abilities. Research on pharmacological treatment of AD is shifting to earlier forms of the disease, including preclinical stages. However, assessment methods traditionally used...

  3. ARTICLE IN PRESS 3 Mapping cortical change in Alzheimer's disease, brain development,

    E-Print Network [OSTI]

    Thompson, Paul

    's disease, schizo- 19 phrenia, normal aging, and abnormal brain development based on 20 imaging data, not seen in individual brain scans, often emerge when 45population-based brain data are averaged School of Medicine, Los Angeles, CA 90095-1769, United States 9 b Child Psychiatry Branch, NIMH, Bethesda

  4. Ada : context-sensitive context-sensing on mobile devices

    E-Print Network [OSTI]

    Chen, Yu-Han, S.M. Massachusetts Institute of Technology

    2013-01-01

    This thesis describes the design, implementation, and evaluation of Ada, a context-sensing service for mobile devices. Ada explores new points in the accuracy-energy-responsiveness design space for mobile context sensing. ...

  5. Neuroinflammation in Alzheimer's disease

    E-Print Network [OSTI]

    2015-01-01

    pathogens. Activation of the proteolytic complement cascade results in opsonisation and, ultimately, in lysis of microorganisms.

  6. Neuroinflammation in Alzheimer's disease

    E-Print Network [OSTI]

    2015-01-01

    Research Group. Naproxen and celecoxib do not prevent AD inResearch Group (2007 and Celecoxib 100 mg twice daily orResearch Group (2007 and Celecoxib 100 mg twice daily or

  7. Neuroinflammation in Alzheimer's disease

    E-Print Network [OSTI]

    2015-01-01

    PS, Schmeidler J, Pasinetti GM. Randomized pilot study of6, interleukin 1?, and GM-CSF. 66 This observation suggests

  8. CAMPUS PEDESTRIAN FACILITIES ADA ASSESSMENT & SURVEY

    E-Print Network [OSTI]

    Escher, Christine

    CAMPUS PEDESTRIAN FACILITIES ADA ASSESSMENT & SURVEY OREGONSTATEUNIVERSITY(OSU) #12;SZSCONSULTING) 130 Oak Creek Corvallis, OR 97331-2001 Re: OSU Campus Accessibility Survey and Assessment ­ Pedestrian Facilities Dear Mike, We are pleased to submit this facility report for the campus pedestrian facility

  9. A novel approach to the identification and quantitative elemental analysis of amyloid deposits-Insights into the pathology of Alzheimer's disease

    SciTech Connect (OSTI)

    Rajendran, Reshmi; Minqin, Ren [Centre for Ion Beam Applications, Department of Physics, Blk S 12, Faculty of Science, National University of Singapore, 2, Science Drive 3, Singapore 117542 (Singapore)] [Centre for Ion Beam Applications, Department of Physics, Blk S 12, Faculty of Science, National University of Singapore, 2, Science Drive 3, Singapore 117542 (Singapore); Ynsa, Maria Dolores [Centro de Micro-Analisis de Materiales (CMAM), Universidad Autonoma de Madrid, Campus de Cantoblanco, 28049 Madrid (Spain)] [Centro de Micro-Analisis de Materiales (CMAM), Universidad Autonoma de Madrid, Campus de Cantoblanco, 28049 Madrid (Spain); Casadesus, Gemma [Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106 (United States)] [Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106 (United States); Smith, Mark A.; Perry, George [Department of Pathology, Case Western Reserve University, Cleveland, OH 44106 (United States)] [Department of Pathology, Case Western Reserve University, Cleveland, OH 44106 (United States); Halliwell, Barry [Department of Biochemistry, National University of Singapore (Singapore)] [Department of Biochemistry, National University of Singapore (Singapore); Watt, Frank, E-mail: phywattf@nus.edu.sg [Centre for Ion Beam Applications, Department of Physics, Blk S 12, Faculty of Science, National University of Singapore, 2, Science Drive 3, Singapore 117542 (Singapore)] [Centre for Ion Beam Applications, Department of Physics, Blk S 12, Faculty of Science, National University of Singapore, 2, Science Drive 3, Singapore 117542 (Singapore)

    2009-04-24

    There is considerable interest in the role of metals such as iron, copper, and zinc in amyloid plaque formation in Alzheimer's disease. However to convincingly establish their presence in plaques in vivo, a sensitive technique is required that is both quantitatively accurate and avoids isolation of plaques or staining/fixing brain tissue, since these processes introduce contaminants and redistribute elements within the tissue. Combining the three ion beam techniques of scanning transmission ion microscopy, Rutherford back scattering spectrometry and particle induced X-ray emission in conjunction with a high energy (MeV) proton microprobe we have imaged plaques in freeze-dried unstained brain sections from CRND-8 mice, and simultaneously quantified iron, copper, and zinc. Our results show increased metal concentrations within the amyloid plaques compared with the surrounding tissue: iron (85 ppm compared with 42 ppm), copper (16 ppm compared to 6 ppm), and zinc (87 ppm compared to 34 ppm).

  10. Ada, Ohio: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION JEnvironmental Jump to:EAand DaltonSolar Energy LLC Jump to:Izu-Oshima Volcano, CentralAda

  11. ADA ES Inc | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX ECoop IncIowa (UtilityMichigan)data bookresult9) JumpMultipleSpringsACHP - SectionADA ES

  12. Improving Static Analysis Accuracy on Concurrent Ada Programs

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    Improving Static Analysis Accuracy on Concurrent Ada Programs: Complexity Results and Empirical presents several techniques for improving the accuracy of static analysis of concurrent Ada programs. We the complexity of performing analysis on those representations. Inaccuracies in the static analysis are reflected

  13. Hydraulic Capacity of an ADA Compliant Street Drain Grate

    SciTech Connect (OSTI)

    Lottes, Steven A.; Bojanowski, Cezary

    2015-09-01

    Resurfacing of urban roads with concurrent repairs and replacement of sections of curb and sidewalk may require pedestrian ramps that are compliant with the American Disabilities Act (ADA), and when street drains are in close proximity to the walkway, ADA compliant street grates may also be required. The Minnesota Department of Transportation ADA Operations Unit identified a foundry with an available grate that meets ADA requirements. Argonne National Laboratory’s Transportation Research and Analysis Computing Center used full scale three dimensional computational fluid dynamics to determine the performance of the ADA compliant grate and compared it to that of a standard vane grate. Analysis of a parametric set of cases was carried out, including variation in longitudinal, gutter, and cross street slopes and the water spread from the curb. The performance of the grates was characterized by the fraction of the total volume flow approaching the grate from the upstream that was captured by the grate and diverted into the catch basin. The fraction of the total flow entering over the grate from the side and the fraction of flow directly over a grate diverted into the catch basin were also quantities of interest that aid in understanding the differences in performance of the grates. The ADA compliant grate performance lagged that of the vane grate, increasingly so as upstream Reynolds number increased. The major factor leading to the performance difference between the two grates was the fraction of flow directly over the grates that is captured by the grates.

  14. Rice Diseases

    E-Print Network [OSTI]

    Jones, Roger K.

    1987-01-01

    Alzheimer's disease (AD) is the most common form of the dementia in the aging population. ?-amyloid peptide (A?) has been indicated as the most important hallmark of AD and also is believed to be the central trigger of ...

  15. Modularization of the DADAISM Ada Database System Architecture

    E-Print Network [OSTI]

    Keller, Arthur M.

    implemen­ tation paradigm is necessary to handle the evolution of database systems over the next fewPage 1 Modularization of the DADAISM Ada Database System Architecture Arthur M. Keller Gio Wiederhold Stanford University Draft of May 21, 1991 Abstract. We describe a new database management system

  16. Modularization of the DADAISM Ada Database System Architecture

    E-Print Network [OSTI]

    Keller, Arthur M.

    implemen- tation paradigm is necessary to handle the evolution of database systems over the next fewPage 1 Modularization of the DADAISM Ada Database System Architecture Arthur M. Keller Gio Wiederhold Stanford University Draft of May 21, 1991 Abstract. We describe a new database management system

  17. Integrative Analysis of Common Neurodegenerative Diseases Using Gene Association, Interaction Networks and mRNA Expression Data

    E-Print Network [OSTI]

    Koyuturk, Mehmet

    , Inc., Cleveland OH. * Corresponding author Abstract Alzheimer's and Parkinson's diseases (AD and PD Alzheimer's disease (AD) and Parkinson's disease (PD) are caused by progressive degeneration and/or deathIntegrative Analysis of Common Neurodegenerative Diseases Using Gene Association, Interaction

  18. ADA Requirements for Workplace Charging Installation | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative FuelsofProgram:Y-12 Beta-3 Racetracks25 AMOSystemADA Requirements for Workplace

  19. Ada Yonath: Another Pioneering Woman in Science | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergy Webinar: DemonstrationProgramAcquisitionfor theActivities andAda

  20. Ada County, Idaho: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX ECoop IncIowa (UtilityMichigan)dataSuccessful SmartAcomita Lake,Acton,Georgia:Ada

  1. PRE-FIGHT DETECTION Classification of Fighting Situations Using Heirachical AdaBoost

    E-Print Network [OSTI]

    Fisher, Bob

    PRE-FIGHT DETECTION Classification of Fighting Situations Using Heirachical AdaBoost Scott J@inf.ed.ac.uk Keywords: Fight, Pre Fight, Cuboid, AdaBoost. Abstract: Abstract: This paper investigates the detection and classification of fighting and pre and post fighting events when viewed from a video camera. Specifically we

  2. Enhancing synaptogenesis in diseases characterized by deficiencies in brain synapses

    E-Print Network [OSTI]

    Wurtman, Richard Jay

    The loss of hippocampal and cortical synapses, resulting from impaired synaptogenesis, accelerated synaptic degeneration, or both, is one of the earliest neuropathologic findings in Alzheimer’s Disease and is the finding ...

  3. Synaptic Mitochondrial Pathology in Alzheimer’s Disease

    E-Print Network [OSTI]

    Du, Heng; Guo, Lan; Yan, Shirley ShiDu

    2012-06-15

    that synaptic mito- chondria are long lived but are more vulnerable to cumulative damage than nonsynaptic mitochondria (4). Several labora- tories including ours have shown that synaptic mitochondria undergo increased oxidation during aging (2, 25, 54). In ad...- mission, which entails presynaptic neurotransmitter release to synaptic cleft to stimulate postsynaptic neurons. ATP is essential to many steps of synaptic transmission such as the tethering, uncoating, and refilling of synaptic vesicles (50, 59, 81...

  4. O2-06-05 AVOXEL-BASED MORPHOMETRY STUDY OF VOLUMETRIC MRI IN FAMILIAL ALZHEIMER'S

    E-Print Network [OSTI]

    Thompson, Paul

    O2-06-05 AVOXEL-BASED MORPHOMETRY STUDY OF VOLUMETRIC MRI IN FAMILIAL ALZHEIMER'S DISEASE David the different groups. Tissue segmentation and spatial normalization of volumetric T1-weighted images were

  5. Discriminative MR Image Feature Analysis for Automatic Schizophrenia and Alzheimer's

    E-Print Network [OSTI]

    neuroradiologists. Most work in automatic or semi- automatic MR neuroimage classification [1,5,14,7,16] has beenDiscriminative MR Image Feature Analysis for Automatic Schizophrenia and Alzheimer's Disease Classification Yanxi Liu1 , Leonid Teverovskiy1 , Owen Carmichael1 , Ron Kikinis2 , Martha Shenton2 , Cameron S

  6. U.S. Environmental Protection Agency's Robert S. Kerr Environmental Research Center, Ada, Oklahoma

    SciTech Connect (OSTI)

    Farrar-Nagy, S.; Voss, P.; Van Geet, O.

    2006-10-01

    U.S. EPA's Robert S. Kerr Environmental Research Center, Ada, Oklahoma, has reduced its annual energy consumption by 45% by upgrading its building mechanical system and incorporating renewable energy.

  7. Molecular regulators of neurogenesis in Alzheimer's disease

    E-Print Network [OSTI]

    Crews, Leslie Anne

    2010-01-01

    451-460. Lazarov, O. , and Marr, R. A. (2009). NeurogenesisNeurology 67, 1486- Singer O, Marr RA, Rockenstein E, Crewsmodels, please see ( Lazarov and Marr, 2009)). However, the

  8. Body Composition in Early Alzheimer's Disease

    E-Print Network [OSTI]

    Burns, Jeffrey M.

    2009-01-09

    performance) to 57 (best performance). 9 Neuropsychological Assessment: A trained psychometrician administered a standard psychometric battery to all participants as previously described. 14-16 The battery included standard measures of memory (WMS... total body lean mass (in kg) by the square of height (m 2 ). Neuroimaging: Structural MRI was obtained on all participants using a Siemens 3.0 Tesla Allegra MRI scanner at the Hoglund Brain Imaging Center. High-resolution T1- weighted anatomic...

  9. Longitudinal Medication Usage in Alzheimer Disease Patients

    E-Print Network [OSTI]

    on ChEIs.1,5­8 In addition to ChEIs and memantine, AD patients are likely to be prescribed other examined in detail patterns of cholinesterase inhibitors (ChEIs) and memantine use and explored characteristics on ChEIs/ memantine use over time. Independent variables included measures of function, cognition

  10. Alberta Alzheimer Research Program III Description

    E-Print Network [OSTI]

    Michelson, David G.

    Alberta Alzheimer Research Program III Description The Alzheimer Society of Alberta and Northwest Territories (ASANT) and the Alberta Prion Research Institute (Prion Institute) present the Alberta Alzheimer Research Program (AARP) III. The AARP III allows qualified Alberta-based investigators to seek funding

  11. GARLIC : GenericAda ReusableLibrary for Interpartition Yvon Kermarrec

    E-Print Network [OSTI]

    Tardieu, Samuel

    GARLIC : GenericAda ReusableLibrary for Interpartition Yvon Kermarrec TBlkom Bretagne DCpartement on issues of interprocessor communication, since this is the core element of our software architecture. We system comprises a network of computers and the software applications that execute on them

  12. Structural imaging biomarkers of Alzheimer's disease: predicting disease progression

    E-Print Network [OSTI]

    Boyer, Edmond

    relatively high accuracy on all baseline ADNI1 data (excluding the 3% failing 5800), Bor- deaux, France c McConnell Brain Imaging Centre, Montreal Neurological@cfin.au.dk 1 Data used in the preparation of this article were obtained from

  13. Ada County, Idaho ASHRAE 169-2006 Climate Zone | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION JEnvironmental Jump to:EAand DaltonSolar Energy LLC Jump to:Izu-Oshima Volcano, CentralAda County,

  14. Neurodegenerative diseases: Lessons from genome-wide screens in small model organisms Molecular mechanisms of aging-related neurodegenerative diseases: emerging views

    E-Print Network [OSTI]

    Breitling, Rainer

    , including Parkinson's disease, polyglutamine expansion diseases and Alzheimer's disease, are associated used to model these diseases and high throughput genetic screens using these models have led-analysis #12;3 Introduction Several age-related neurodegenerative diseases, including Parkinson's disease

  15. Locomotive Micro-Implant with Active Electromagnetic Propulsion Daniel Pivonka, Ada S. Y. Poon, and Teresa H. Meng

    E-Print Network [OSTI]

    Poon, Ada

    Locomotive Micro-Implant with Active Electromagnetic Propulsion Daniel Pivonka, Ada S. Y. Poon An active locomotive technique requiring only an ex- ternal power source and a static magnetic field is pre- sented, and its operation is analyzed and simulated. For a modest static MRI magnetic field of 1 T

  16. Learning to predict is spared in mild cognitive impairment due to Alzheimer’s disease

    E-Print Network [OSTI]

    Baker, Rosalind; Bentham, Peter; Kourtzi, Zoe

    2015-06-24

    and longer response times (Curran, 1997; Simon, Yokomizo, & Bottino, 2012). In contrast, using an explicit prediction test, we demonstrate that predictions related to identification of objects are facilitated by implicit knowledge of temporal context. Our... -driven attention in the brain. Nature Reviews Neuroscience, 3(3), 201-215. doi: 10.1038/nrn755 Curran, T. (1997). Effects of aging on implicit sequence learning: Accounting for sequence structure and explicit knowledge. Psychology Research, 60, 24 - 41...

  17. RAGE and Alzheimer’s Disease: A Progression Factor for Amyloid-?-Induced Cellular Perturbation?

    E-Print Network [OSTI]

    Yan, Shirley ShiDu; Bierhaus, Angelika; Nawroth, Peter P.; Stern, David M.

    2009-04-01

    Receptor for Advanced Glycation Endproducts (RAGE) is a multiligand member of the immunoglobulin superfamily of cell surface molecules which serves as a receptor for amyloid-? peptide (A?) on neurons, microglia, astrocytes, ...

  18. S100 Inhibitors: A New Paradigm for Treating Alzheimer’s Disease 

    E-Print Network [OSTI]

    Mathai, David 1991-

    2011-04-27

    pathology. These plaques are deposits of the amyloid-beta (A-Beta) peptide, which is derived from a larger molecule known as the amyloid precursor protein (APP). APP can be processed in one of two ways: in the non-amyloidogenic pathway, APP cleavage...

  19. Brain-targeted proanthocyanidin metabolites for Alzheimer's disease treatment

    E-Print Network [OSTI]

    2012-01-01

    WY (2006) Metabolism of green tea catechins: an overview.Town T, Tan J (2005) Green tea epigallocatechin-3-gallate (

  20. What is new and exciting in Alzheimer's disease research?

    E-Print Network [OSTI]

    Jonsson1 et al., Nature | Letter 2012 1deCODE genetics, 101 Reykjavik, Iceland #12;#12;Alan Turing) at the National Codes Centre at Bletchley Park In 2012 two 70-year-old papers by Alan Turing on the theory of code

  1. BONE LOSS IN RELATION TO HYPOTHALAMIC ATROPHY IN ALZHEIMER'S DISEASE

    E-Print Network [OSTI]

    Loskutova, Natalia Y.

    2011-05-12

    . The body of presented work extends the literature on a relationship between bone loss and AD. Overall, the presented work provides initial evidence that accelerated bone loss observed in individuals in the early stages of AD may be partially due...

  2. A State-Wide Research Network for Alzheimer's Disease

    SciTech Connect (OSTI)

    Mintzer, Jacobo E.; Bachman, D. L.; Stuckey, M.; Ebeling, M.; Wagner, M. T.; Evans, W. J.; Hirth, V.; Walker, A.; Joglekar, R.; Faison, W.

    2014-03-13

    The Specific Aim of the proposal was to develop an administrative structure that will facilitate the development of AD research across the state of SC by providing key services such as (but not limited to) seeking funding research opportunities, financial tracking, regulatory management, central recruitment, training for investigators and coordinators, data collection, data storing, and data processing to researchers across the state.

  3. Selective disruption of the cerebral neocortex in alzheimer's disease

    E-Print Network [OSTI]

    2010-01-01

    Martin Reuter 1 , Howard J. Cabral 3 , Christopher P. Hess1048–1055. 21. Desikan RS, Cabral HJ, Hess CP, Dillon WP,25. Desikan RS, Fischl B, Cabral HJ, Kemper TL, Guttmann CR,

  4. Decreasing your risk for Alzheimer's disease through diet

    E-Print Network [OSTI]

    ) #12;Resveratrol A plant-based polyphenol In dark red/purple plants Apples Blueberries Blackberries Acai berries Red grapes #12;Resveratrol Antioxidant, anti-inflammatory In animal models, shown

  5. Insight into Alzheimer's, cancer, anemia gleaned from ribosome...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Insights from ribosome research Insight into Alzheimer's, cancer, anemia gleaned from ribosome research Groundbreaking study of the human ribosome reveals tiny molecular machine is...

  6. Available online at www.sciencedirect.com A cellular perspective on conformational disease: the role of

    E-Print Network [OSTI]

    Morimoto, Richard

    of destabilized proteins. Genetic mutations in conformational disease-associated proteins, as well as exposure in the genetic background may account for some of the cell-type specificity observed in disease, even when neurodegenerative diseases, including Alzheimer's Dis- ease (AD), Parkinson's Disease (PD), Amyotrophic Lat- eral

  7. Exploring candidate genes for human brain diseases from a brain-specific gene network

    E-Print Network [OSTI]

    Jiang,Tianzi

    identifying multiple candidate genes for genetic human brain diseases from a brain-specific gene network; Candidate genes Many common human brain diseases, such as schizo- phrenia, Alzheimer's disease, Parkinson's disease, depres- sion, etc., have prominent genetic components [1,2]. Most researchers think that large

  8. Multivariate Protein Signatures of Pre-Clinical Alzheimer's Disease in the Alzheimer's Disease Neuroimaging Initiative (ADNI) Plasma Proteome Dataset

    E-Print Network [OSTI]

    Johnstone, Daniel; Milward, Elizabeth A.; Berretta, Regina; Moscato, Pablo

    2012-01-01

    Peptide (BNP) *Betacellulin (BTC) CD5 Fas Ligand (FasL)II & Betacellulin (ApoA-II – BTC) Angiopoietin-2 & Neuronal

  9. DISEASE-SPECIFIC PROBABILISTIC BRAIN ATLASES

    E-Print Network [OSTI]

    Thompson, Paul

    algorithms for knowledge-based image analysis, automated image labeling, tissue classification, data mining School of Medicine, Los Angeles, CA 2 Alzheimer's Disease Center, UCLA School of Medicine, Los Angeles Westwood Plaza, Los Angeles, CA 90095-1769 Phone: (310) 206-2101 Fax: (310) 206-5518 E-mail: thompson

  10. Enabling Security in Cloud Storage SLAs with CloudProof Raluca Ada Popa Jacob R. Lorch David Molnar Helen J. Wang Li Zhuang

    E-Print Network [OSTI]

    Enabling Security in Cloud Storage SLAs with CloudProof Raluca Ada Popa Jacob R. Lorch David Molnar,dmolnar,helenw,lizhuang}@microsoft.com ABSTRACT Several cloud storage systems exist today, but none of them provide security guaranteesProof, a secure storage system specifically de- signed for the cloud. In CloudProof, customers can not only detect

  11. Virginia Commonwealth University is committed to a policy of nondiscrimination in employment and education and complies with the requirements of the Americans with Disabilities Act of 1990 (ADA) and the Rehabilitation

    E-Print Network [OSTI]

    Hammack, Richard

    ) and the Rehabilitation Act of 1973, which prohibit discrimination against persons with disabilities. The University ADA and The Rehabilitation Act #12;Students or faculty seeking additional information regarding academic-related issues

  12. Alzheimer caregiving stress and atherosclerotic disease : psychosocial and physiological pathways linking chronic stress to disease

    E-Print Network [OSTI]

    Buehler, Susan Kyung; Buehler, Susan Kyung

    2012-01-01

    Medicine, 52(3-4), 208-212. O'Leary, D. H. , Polak, J. F. ,A. , Sidney, S. , & O'Leary, D. H. (2010). Segment-specificand myocardial infarction (O'Leary et al. , 1999). Moreover,

  13. Dual tasking, executive functioning and socio-behavioural functioning in healthy ageing and Alzheimer’s Disease

    E-Print Network [OSTI]

    Crompton, Catherine

    2011-06-29

    This between groups experimental design study explores the relationship between executive functioning, dual task ability and socio-behavioural performance in healthy ageing. Case study methodology was also used to explore ...

  14. Multimodal Imaging of Alzheimer Pathophysiology in the Brain's Default Mode Network

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Shin, Jonghan; Kepe, Vladimir; Small, Gary W.; Phelps, Michael E.; Barrio, Jorge R.

    2011-01-01

    The spatial correlations between the brain's default mode network (DMN) and the brain regions known to develop pathophysiology in Alzheimer's disease (AD) have recently attracted much attention. In this paper, we compare results of different functional and structural imaging modalities, including MRI and PET, and highlight different patterns of anomalies observed within the DMN. Multitracer PET imaging in subjects with and without dementia has demonstrated that [C-11]PIB- and [F-18]FDDNP-binding patterns in patients with AD overlap within nodes of the brain's default network including the prefrontal, lateral parietal, lateral temporal, and posterior cingulate cortices, with the exception of the medial temporalmore »cortex (especially, the hippocampus) where significant discrepancy between increased [F-18]FDDNP binding and negligible [C-11]PIB-binding was observed. [F-18]FDDNP binding in the medial temporal cortex—a key constituent of the DMN—coincides with both the presence of amyloid and tau pathology, and also with cortical areas with maximal atrophy as demonstrated by T1-weighted MR imaging of AD patients.« less

  15. In Vivo Characterization of CLR01, an Aggregation and Toxicity Inhibitor, with an Alzheimer's Disease Focus

    E-Print Network [OSTI]

    Attar, Aida

    2013-01-01

    Hou H, et al. (2005) Green tea epigallocatechin-3-gallate (neurorestorative activity of green tea polyphenols: specialHou H, et al. (2005) Green tea epigallocatechin-3-gallate (

  16. Multiple Events Lead to Dendritic Spine Loss in Triple Transgenic Alzheimer's Disease Mice

    E-Print Network [OSTI]

    2010-01-01

    amyloid deposition leads to local synaptic abnormalities andMultiple Events Lead to Dendritic Spine Loss in Tripleal. (2010) Multiple Events Lead to Dendritic Spine Loss in

  17. DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease

    E-Print Network [OSTI]

    2013-01-01

    Institute of Oncology of Asturias (IUOPA), HUCA, Universidada del Principado de Asturias (IUOPA), HUCA, Universidad de

  18. Multimodality MRI-based Brain Network Analysis: Applications to Genetic Risk for Alzheimer's Disease

    E-Print Network [OSTI]

    Brown, Jesse Aaron

    2013-01-01

    Robert Landick, Francisco J. Asturias, Seth A. Darst (2010).Hudmon, Francisco J. Asturias, Roger D. Kornberg (2006).advisor, Dr. Francisco Asturias. He took a chance on me when

  19. Journal of Alzheimer's Disease 29 (2012) 112 DOI 10.3233/JAD-2012-120166

    E-Print Network [OSTI]

    Mandal, Pravat K.

    2012-01-01

    Centre, Gurgaon, India bDepartment of Neurology, All India Institute of Medical Sciences, New Delhi, India Accepted 1 March 2012 Abstract. Magnetic resonance spectroscopy (MRS) plays an important role towards alkaline side compared to MCI but did not reach statistical significance level. The pH (left

  20. Effects of Familial Alzheimer's Disease Mutations on the Folding Nucleation of the Amyloid ?-Protein

    E-Print Network [OSTI]

    2008-01-01

    nucleation of amyloid ?-protein folding. Proc. Natl Acad.dynamics method for protein folding. Chem. Phys. Lett. 314,Atomic simulations of protein folding using the replica

  1. Nutrition and Alzheimer's Disease: The Role of Folate and Vitamin B

    E-Print Network [OSTI]

    Edmonds, Zachary V.

    1999-01-01

    Karlinsky H. Folate, vitamin B12 and cognitive impairment inH, Surron L, Ueland PU. Folate, vitamin B12, and serum totalBottiglieri T. Folate, vitamin B12, and neuropyschiatric

  2. DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease

    E-Print Network [OSTI]

    2013-01-01

    PLoS One 2009; 2: e895. Song CX, Szulwach KE, Fu Y, Dai Q,Szulwach KE, Li X, Li Y, Song CX, Wu H, Dai Q, et al. 5-hmC-cells), cerebral cortex (CX, CA1, CA3 and den- tate gyrus)

  3. Improved Classification of Alzheimer's Disease Data via Removal of Nuisance Variability

    E-Print Network [OSTI]

    Koikkalainen, Juha; Polonen, Harri; Mattila, Jussi; van Gils, Mark; Soininen, Hilkka; Lotjonen, Jyrki

    2012-01-01

    Initiative 1 VTT Technical Research Centre of Finland,Tampere, Finland, 2 Department ofUniversity of Eastern Finland, Kuopio, Finland, 3 Department

  4. Longitudinal assessment of global and regional atrophy rates in Alzheimer's disease and dementia with Lewy bodies

    E-Print Network [OSTI]

    Mak, Elijah; Su, Li; Williams, Guy B.; Watson, Rosie

    2015-02-07

    dementia using serial magnetic resonance imaging. Mov. Disord. 20 (12), 1571–1576. http://dx.doi.org/10.1002/mds.2065216116613. Cover, K.S., van Schijndel, R.A., van Dijk, B.W., Redolfi, A., Knol, D.L., Frisoni, G.B., Barkhof, F., Vrenken, H., neu...

  5. Multimodality MRI-based Brain Network Analysis: Applications to Genetic Risk for Alzheimer's Disease

    E-Print Network [OSTI]

    Brown, Jesse Aaron

    2013-01-01

    Acad. Sci. U.S.A. 107, 4734–4739. Brown, J. A. , Terashima,Acad. Sci. U.S.A. 107, 4734–4739. Bondi, M.W. , Houston,

  6. DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease

    E-Print Network [OSTI]

    2013-01-01

    putamen, substantia nigra, hypothalamus, globus pallidus andÀ 0.90 to À 0.95), hypothalamus ( À 0.82), globus pallidus (

  7. Targeting the brain : identifying and inhibiting harmful protein-amyloid interactions in Alzheimer's disease

    E-Print Network [OSTI]

    Habib, Lila K.

    2011-01-01

    mixed with 5% potassium ferrocyanide and incubated at roomfor 15 minutes. Potassium ferrocyanide reacts with ferriciron to form ferric ferrocyanide, a blue colloidal complex

  8. UncorrectedAuthorProof Journal of Alzheimer's Disease xx (20xx) xxx

    E-Print Network [OSTI]

    , PH9 Center, room 210, 630 West 168th Street, New York, NY 10032, USA. Tel.: +1 212 3054730; E. / Lessons from Epidemiologic Research about Risk Factors Thomson Reuters Bibliometric analysis tool called33

  9. DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT

    E-Print Network [OSTI]

    Jones, Rob; Sheehan, Bart; Phillips, Patrick; Juszczak, Ed; Adams, Jessica; Baldwin, Ashley; Ballard, Clive; Banerjee, Sube; Barber, Bob; Bentham, Peter; Brown, Richard; Burns, Alistair; Dening, Tom; Findlay, David; Gray, Richard; Griffin, Mary; Holmes, Clive; Hughes, Alan; Jacoby, Robin; Johnson, Tony; Jones, Roy; Knapp, Martin; Lindesay, James; McKeith, Ian; McShane, Rupert; Macharouthu, Ajay; O'Brien, John; Onions, Caroline; Passmore, Peter; Raftery, James; Ritchie, Craig; Howard, Rob; Domino-ad Team

    2009-07-24

    . Method DOMINO-AD is a pragmatic, 15 centre, double-blind, randomized, placebo controlled trial. Patients with AD, currently living at home, receiving donepezil 10 mg daily, and with Standardized Mini-Mental State Examination (SMMSE) scores between 5...

  10. Sleep and markers of cardiovascular disease risk in elderly Alzheimer's caregivers

    E-Print Network [OSTI]

    Schwartz, Jennifer

    2012-01-01

    30(12):645-52. Espeland MA, O'Leary D H, Terry JG, Morgan T,82(4):1230-42. Espeland MA, O'Leary D H, Terry JG, Morgan T,circulation 2004;35(9):2150-4. O'Leary DH, Polak JF, Kronmal

  11. Improving the Quality of EEG Data in Patients with Alzheimers Disease Using ICA

    E-Print Network [OSTI]

    Cichocki, Andrzej

    , electromyographic, elec- trodermal, electrovascular, and respiratory signals) may interfere with the EEG in the form

  12. Brain Imaging with Positron Emission Tomography: Quantification and Biomedical Applications in Alzheimer's Disease and Brain Tumors

    E-Print Network [OSTI]

    Wardak, Mirwais

    2013-01-01

    AB, Elson LM. The human brain coloring book. 1st ed. New21. Toga AW, Mazziotta JC. Brain mapping : the systems. SanSR, Phelps ME. Imaging Brain Function with Positron Emission

  13. Targeting the brain : identifying and inhibiting harmful protein-amyloid interactions in Alzheimer's disease

    E-Print Network [OSTI]

    Habib, Lila K.

    2011-01-01

    for enhanced delivery of quinine dihydrochloride to theand anti- malarial medications (quinine dihydrochloride and

  14. A Novel Sensitive Method of Detecting Mnemonic Decline in Mouse Model of Alzheimer's Disease 

    E-Print Network [OSTI]

    Simmons, Rebecca

    2011-01-11

    be used as an early diagnostic tool for such decline, and a rodent model that is sensitive to this deficit could be valuable in the search for therapies to prevent or reverse such impairments. The goal of this study is to develop an analogous animal model...

  15. UNCORRECTEDPROOF 2 3D characterization of brain atrophy in alzheimer's disease and mild

    E-Print Network [OSTI]

    Thompson, Paul

    ,a Arthur W. Toga,a Natasha Lepore,a 5 Yi-Yu Chou,a Caroline Brun,a Ming-Chang Chiang,a Marina Barysheva Harvey,e John Kornak,f Norbert Schuff,g Lauren Boreta,g Gene E. Alexander,i 9 Michael W. Weiner,g,h Paul

  16. The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer's disease

    E-Print Network [OSTI]

    2011-01-01

    and Dot Blot Assay Presence of Ab epitope in WSN-Ab 1-10 or WSN-Ab 1-7 was confirmed by Western blot using anti-Abwith rabbit polyclonal anti-WSN serum (gift of Drs. Thomas

  17. THREE-DIMENSIONAL STRUCTURE OF THE LITHOSTATHINE PROTOFIBRIL, A PROTEIN INVOLVED IN ALZHEIMER'S DISEASE

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    interactions into a tetramer. Each tetramer then linked up with another tetramer as the result of longitudinal

  18. Associations between potentially modifiable risk factors and Alzheimer's disease: A Mendelian random

    E-Print Network [OSTI]

    Østergaard, Søren D.; Mukherjee, Shubhabrata; Sharp, Stephen J.; Proitsi, Petroula; Lotta, Luca A.; Day, Felix; Perry, John R. B.; Boehme, Kevin L.; Walter, Stefan; Kauwe, John S.; Gibbons, Laura E.; Alzheimer’s Disease Genetics Consortium; The Genetic and Environmental Risk in AD Consortium; The EPIC-InterAct consortium; Larson, Eric B.; Powell, John F.; Laugenberg, Claudia; Crane, Paul K.; Wareham, Nicholas J.; Scott, Robert A.

    2015-06-09

    of insulin resistance and body fat distribution in type 2 diabetes, independently of obesity. Diabetes. 2014. 16. Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, et al. Association analyses of 249,796 individuals reveal 18 new... with autopsy-confirmed diagnosis and no clinical diagnosis, the age at death was used for age at diagnosis. For all studies, the age used for CNEs was the age of last exam or age at death for those for whom age at exam was not available. Case and CNE subjects...

  19. Journal of Alzheimer's Disease 14 (2008) 235245 235 Three-Dimensional Tomographic Imaging

    E-Print Network [OSTI]

    Dunin-Borkowski, Rafal E.

    2008-01-01

    of Denmark, DK-2800 Kongens Lyngby, Denmark e Department of Pathology, Case Western Reserve University microscopy (HR-TEM), energy dispersive X-ray (EDX) spectroscopy and electron energy-loss spectroscopy (EELS of these important roles, iron can also be toxic, with certain forms participating in the production of free radicals

  20. Automated MRI measures identify individuals with mild cognitive impairment and Alzheimers disease

    E-Print Network [OSTI]

    2009-01-01

    S. Desikan, 1,2 Howard J. Cabral, 3 Christopher P. Hess, 431: 968–80. Desikan RS, Cabral HJ, Settecase F, Hess CP,

  1. In Vivo Characterization of CLR01, an Aggregation and Toxicity Inhibitor, with an Alzheimer's Disease Focus

    E-Print Network [OSTI]

    Attar, Aida

    2013-01-01

    M, et al. (2010) Resveratrol selectively remodels solubleneurotrophic factor and resveratrol that is currently in3-gallate [283,284], resveratrol [285], A?42 C-terminal

  2. Induced pluripotent stem-cell-derived models of sporadic and familial Alzheimer's disease

    E-Print Network [OSTI]

    Israel, Mason Arthur

    2011-01-01

    Induced pluripotent stem-cell-derived models of sporadic andcells, glia and neurons derived from human pluripotent stemhuman ES and iPS cell-derived neurons. Proc. Natl. Acad.

  3. Sorghum Diseases

    E-Print Network [OSTI]

    Amador, Jose; Berry, Robert W.; Frederiksen, Richard A.; Horne, C. Wendell; Thames, Walter H.; Toler, Robert W.

    1969-01-01

    Foreign animal disease can cause serious damage to the United States (US) agricultural sector and foot-and-mouth disease (FMD), in particular, poses a serious threat. FMD causes death and reduced fecundity in infected ...

  4. Information Regarding MENINGOCOCCAL DISEASE

    E-Print Network [OSTI]

    . Meningococcal disease is a serious disease, caused by bacteria. Meningococcal disease is a contagious

  5. Characterisation of a mouse model of chronic cerebral hypoperfusion and its application to investigating the impact of hypoperfusion on the development of Alzheimer’s disease 

    E-Print Network [OSTI]

    Coltman, Robin Bruce

    2012-06-22

    The integrity of brain white matter is vital for the interneuronal signalling between distinct brain regions required for normal cognitive function. White matter integrity is compromised with ageing and could contribute ...

  6. In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer¿s disease pathology

    E-Print Network [OSTI]

    2013-01-01

    Celular, Genetica y Fisiologia, Facultad de Ciencias,Celular, Genetica y Fisiologia, Facultad de Ciencias,

  7. Tumor necrosis factor-alpha synthesis inhibitor 3,6' -dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease

    E-Print Network [OSTI]

    2012-01-01

    markedly elevated in old versus adult vehicle-treated 3xTg-and hippocampus of old versus adult 3xTg-AD mice, which wasthe drug-treated old and both sets of adult mice. Data are

  8. GPR50, a potential factor involved in psychiatric disorders interacts with Alzheimer’s disease-related protein ?- secretase (BACE1) 

    E-Print Network [OSTI]

    Li, Qian

    2014-11-28

    GPR50, an X-linked orphan G protein-coupled receptor (GPCR), is a risk factor for bipolar disorder (BD) in female subjects. It has been shown that GPR50 plays a part in neurite outgrowth, glucocorticoid receptor signalling ...

  9. Simultaneous Segmentation and Grading of Hippocampus for Patient Classification with Alzheimer's

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Simultaneous Segmentation and Grading of Hippocampus for Patient Classification with Alzheimer library used during our experiments was composed by 2 populations, 50 Cognitively Normal subjects (CN of the HC at the same time resulted in an efficient patient classification with a success rate of 90

  10. Ovariectomy Induces a Shift in Fuel Availability and Metabolism in the Hippocampus of the Female Transgenic Model of Familial Alzheimer's

    E-Print Network [OSTI]

    Ding, Fan; Yao, Jia; Zhao, Liqin; Mao, Zisu; Chen, Shuhua; Brinton, Roberta Diaz

    2013-03-26

    Previously, we demonstrated that reproductive senescence in female triple transgenic Alzheimer's (3×TgAD) mice was paralleled by a shift towards a ketogenic profile with a concomitant decline in mitochondrial activity in ...

  11. Beryllium disease

    SciTech Connect (OSTI)

    Not Available

    1991-12-20

    After two workers at the nuclear weapons plant at Oak Ridge National Laboratory in Tennessee were diagnosed earlier this year with chronic beryllium disease (CBD), a rare and sometimes fatal scarring of the lungs, the Department of Energy ordered up a 4-year probe. Now, part of that probe has begun - tests conducted by the Oak Ridge Associated Universities' Center for Epidemiological Research measuring beryllium sensitivity in 3,000 people who've been exposed to the metal's dust since Manhattan Project managers opened the Y-12 plant at Oak Ridge in 1943. Currently, 119 Y-12 employees process beryllium, which has a number of industrial uses, including rocket heat shields and nuclear weapon and electrical components. The disease often takes 20 to 25 years to develop, and the stricken employees haven't worked with beryllium for years. There is no cure for CBD, estimated to strike 2% of people exposed to the metal. Anti-inflammatory steroids alleviate such symptoms as a dry cough, weight loss, and fatigue. Like other lung-fibrosis diseases that are linked to lung cancer, some people suspect CBD might cause some lung cancer. While difficult to diagnose, about 900 cases of CBD have been reported since a Beryllium Case Registry was established in 1952. The Department of Energy (DOE) estimates that about 10,000 DOE employees and 800,000 people in private industry have worked with beryllium.

  12. A learning deficit related to age and b-amyloid plaques in a mouse model of Alzheimer's disease 

    E-Print Network [OSTI]

    Chen, Guiquan; Chen, Karen S; Knox, Jane H; Inglis, Jennifer; Bernard, Andrew; Martin, Stephen J; Justice, Alan; McConlogue, Lisa; Games, Dora; Freedman, Stephen B; Morris, Richard G M

    2000-12-21

    Mice that overexpress the human mutant amyloid precursor protein (hAPP) show learning deficits, but the apparent lack of a relationship between these deficits and the progressive b-amyloid plaque formation that the hAPP ...

  13. The effect of delay on conceptual and perceptual priming in Alzheimer's disease : relationship to attention and cortical activation

    E-Print Network [OSTI]

    Kane, Amy E.

    2009-01-01

    for each group. The cost index was defined as the difference38) = 7.67, p cost index was significantly largerwith group (AD,EC) and index (cost, benefit) as factors

  14. Exploration of the role of gangliosides and cholesterol in the mechanism of ?-amyloid neurotoxicity in Alzheimer's disease 

    E-Print Network [OSTI]

    Yoo, Suk Joon

    2002-01-01

    observed in the brains of AD patients. Currently, a variety of evidence indicates that A?-membrane interactions play an important role in the mechanism of A? neurotoxicity. In particular, cholesterol and gangliosides were reported to be related closely...

  15. Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study

    E-Print Network [OSTI]

    2012-01-01

    ters in the placebo group, seven in the 2 gm/day group, andsubjects in the placebo group, seven in the 2 gm/day group,

  16. Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study

    E-Print Network [OSTI]

    2012-01-01

    in the 2 gm/day group, and eight in the 4 gm/day group. Twoin the 2 gm/day group, and for eight in the 4 gm/day group.

  17. Minute Effects of Sex on the Aging Brain: A Multisample Magnetic Resonance Imaging Study of Healthy Aging and Alzheimer's Disease

    E-Print Network [OSTI]

    Fjell, Anders M.

    Age is associated with substantial macrostructural brain changes. While some recent magnetic resonance imaging studies have reported larger age effects in men than women, others find no sex differences. As brain morphometry ...

  18. THE ASSOCIATION BETWEEN PHYSICAL ACTIVITY, COGNITIVE FUNCTION, AND PERFORMANCE OF ACTIVITIES OF DAILY LIVING IN PATIENTS WITH EARLY ALZHEIMER'S DISEASE

    E-Print Network [OSTI]

    Jaber, Ala'a Fayez

    2010-05-31

    psychometric battery. Structural MRI was obtained using a Siemens 3.0 Tesla Allegra MRI scanner at the Hoglund Brain Imaging Center located adjacent to the Center on Aging. The outcome measures included: 1) Physical Activity Scale in the Elderly (PASE) and a... modified Community Healthy Activities Model Program for Seniors (CHAMPS): Both questionnaires were used to assess physical activity levels; 2) Physical Performance Test (PPT): This short battery of timed physical tasks was used as a measure of physical...

  19. Binding information in short-term memory: evidence from healthy individuals, Alzheimer's Disease and other clinical populations 

    E-Print Network [OSTI]

    Rodríguez, Mario Alfredo Parra

    Memory binding is a cognitive process that enables complex objects to be stored or retrieved coherently during perception, learning, or action. Binding functions are aimed at reducing the misattribution of the features ...

  20. Supplemental Material to "Identifying Alzheimer's Disease-Related Brain Regions from Multi-Modality Neuroimaging Data using Sparse

    E-Print Network [OSTI]

    Li, Jing

    -Modality Neuroimaging Data using Sparse Composite Linear Discrimination Analysis" I ­ How does the formulation (5) serve

  1. Grape-derived polyphenolics prevent A? oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease

    E-Print Network [OSTI]

    2008-01-01

    also re- ported that resveratrol, a natural polyphe- nolP, Zhao H, Davies P (2005) Resveratrol promotes clearance of

  2. Decreased Proteolytic Activity of the Mitochondrial Amyloid-? Degrading Enzyme, PreP Peptidasome, in Alzheimer's Disease Brain Mitochondria

    E-Print Network [OSTI]

    Alikhani, Nyosha; Guo, Lan; Yan, Shiqiang; Du, Heng; Pinho, Catarina Moreira; Chen, John Xi; Glaser, Elzbieta; Yan, Shirley ShiDu

    2011-01-01

    by the presequence protease, hPreP. J Bioenerg Biomembr 41, 447-451. [29] Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S (2003) Insulin-degrading enzyme regulates the levels of insulin, amyloid beta... by the presequence protease, hPreP. J Bioenerg Biomembr 41, 447-451. [29] Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S (2003) Insulin-degrading enzyme regulates the levels of insulin, amyloid beta...

  3. Gaucher Disease Inherited disorder

    E-Print Network [OSTI]

    Brutlag, Doug

    , spleen, and bone marrow ¡ Many types ¡ Possible link to Parkinson's Disease ¡ Affects 1 in 100,000 #12/> ¡ "Gaucher Disease." Genetics Home Reference ­ Your Guide to Understanding Genetic Conditions. US National Disease." Gene Review. Web 2 Oct. 2012. Genetics

  4. Activity Leader Facilitation of a Rhythm Activity to Engage Persons with Late Stage Alzheimer's-Type Dementia: A Feasibility Study

    E-Print Network [OSTI]

    Coury, Sarah Nicole

    2013-12-31

    The purpose of this study was to determine if an activity leader with little to no formal music background could engage individuals with late stage Alzheimer's-type dementia in a rhythm activity following training by a board-certified music...

  5. Formulation of a Medical Food Cocktail for Alzheimer's Disease: Beneficial Effects on Cognition and Neuropathology in a Mouse Model of the Disease

    E-Print Network [OSTI]

    Parachikova, Anna; Green, Kim N.; Hendrix, Curt; LaFerla, Frank M.

    2010-01-01

    the neuroprotective actions of the green tea polyphenol (-)-is an active ingredient of green tea. It exhibits potent

  6. Role of paraoxonase 1 (PON1) in organophosphate metabolism: Implications in neurodegenerative diseases

    SciTech Connect (OSTI)

    Androutsopoulos, Vasilis P.; Kanavouras, Konstantinos; Tsatsakis, Aristidis M.

    2011-11-15

    Organophosphate pesticides are a class of compounds that are widely used in agricultural and rural areas. Paraoxonase 1 (PON1) is a phase-I enzyme that is involved in the hydrolysis of organophosphate esters. Environmental poisoning by organophosphate compounds has been the main driving force of previous research on PON1 enzymes. Recent discoveries in animal models have revealed the important role of the enzyme in lipid metabolism. However although PON1 function is well established in experimental models, the contribution of PON1 in neurodegenerative diseases remains unclear. In this minireview we summarize the involvement of PON1 genotypes in the occurrence of Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis. A brief overview of latest epidemiological studies, regarding the two most important PON1 coding region polymorphisms PON1-L55M and PON1-Q192R is presented. Positive and negative associations of PON1 with disease occurrence are reported. Notably the MM and RR alleles contribute a risk enhancing effect for the development of some neurodegenerative diseases, which may be explained by the reduced lipoprotein free radical scavenging activity that may give rise to neuronal damage, through distinct mechanism. Conflicting findings that fail to support this postulate may represent the human population ethnic heterogeneity, different sample size and environmental parameters affecting PON1 status. We conclude that further epidemiological studies are required in order to address the exact contribution of PON1 genome in combination with organophosphate exposure in populations with neurodegenerative diseases.

  7. Interim Chronic Beryllium Disease

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-12-08

    Establishes Departmental expectations for addressing chronic beryllium disease throughout the Department until a Departmental rule on beryllium is promulgated. This Notice was replaced by final rule 10 CFR Part 850, Chronic Beryllium Disease Prevention Program, published December 8, 1999.

  8. Understanding Heart Disease

    E-Print Network [OSTI]

    Shen, Jun

    1 Understanding Heart Disease Vietnamese Aspire For Healthy Hearts What Is Heart Disease? Heart the blood vessels going to the heart become narrow and clogged. Blood vessels are long, hollow tubes arteries. When arteries become clogged, it increases the risk of developing heart disease. When the heart

  9. CV Ada Ortiz 1 CURRICULUM VITAE

    E-Print Network [OSTI]

    Sanahuja, Blai

    in Granollers (Spain) Present address: Departament d'Astronomia i Meteorologia Universitat de Barcelona Facultat

  10. Autodetektion mit AdaBoost Magisterarbeit

    E-Print Network [OSTI]

    Grabner, Helmut

    Verfahren erm¨oglicht eine sehr schnelle Verarbeitung, obwohl hohe Detektionsraten erreicht werden k geb¨uhrt meinen Eltern, die mir das Studium nicht zuletzt durch ihre finanzielle Unterst¨utzung erm

  11. Ada, Minnesota: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX ECoop IncIowa (UtilityMichigan)dataSuccessful SmartAcomita

  12. Ada, Oklahoma: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX ECoop IncIowa (UtilityMichigan)dataSuccessful SmartAcomitaOklahoma: Energy Resources

  13. Indiana-Illinois Workshop on Scientific Computing 2014

    E-Print Network [OSTI]

    ... diabetic retinopathy), neurodegenerative diseases (e.g. Alzheimer's disease, Parkinson's disease) and other systemic diseases (e.g. hypertension, diabetes).

  14. Wheat Diseases Atlas. 

    E-Print Network [OSTI]

    McCoy, Norman L.; Berry, Robert W.

    1982-01-01

    to wheat producers over the state on whose farms demonstrations have been conducted and pic tures for this publication were made. WhEAT DisEASES ATLAs Norman L. McCoy and Robert W Berry* INTRODUCTION Wheat diseases have caused untold human suffer ing...

  15. Adventures in Infectious Diseases

    ScienceCinema (OSTI)

    Fisher-Hoch, Susan [University of Texas School of Public Health

    2014-06-25

    Dr. Susan Fisher-Hoch, Virologist and Epidemiologist, will discuss her research and travels associated with viral hemorrhagic fevers. From the Ebola outbreak in Reston, Virginia to outbreaks of Crimean Congo Hemorrhagic Fever in South Africa, Senegal, and Saudi Arabia, Dr. Fisher-Hoch has studied and tracked the pathophysiology of these viral diseases. These studies have led her from the Center for Disease Control in the United States, to Lyon, France where she was instrumental in designing, constructing, and rendering operational a laboratory capable of containing some of the world's most dangerous diseases.

  16. Chronic obstructive pulmonary disease, pulmonary function and cardiovascular disease 

    E-Print Network [OSTI]

    McAllister, David Anthony

    2011-07-05

    Cardiovascular disease is common in Chronic Obstructive Pulmonary Disease (COPD), and forced expiratory volume in one second (FEV1) independently predicts cardiovascular morbidity and mortality. Pathological changes in ...

  17. Osteocytes and Bone Diseases 

    E-Print Network [OSTI]

    Ren, Yinshi

    2015-05-06

    For many centuries, the osteoblast is considered to be responsible for bone formation. It is also believed that an imbalance of osteoblasts (weak) and osteoclasts (strong) is the main cause for bone diseases such as ...

  18. Health & Medicine Heart Disease

    E-Print Network [OSTI]

    Rogers, John A.

    See Also: Health & Medicine Heart Disease· Medical Imaging· Vioxx· Matter & Energy Electronics· Technology· Medical Technology· Reference Artificial heart· Biosensor· Circuit design· Machine· Science and stretchable electronics can map waves of electrical activity in the heart with better resolution and speed

  19. Soybean Diseases Atlas. 

    E-Print Network [OSTI]

    Anonymous,

    1979-01-01

    new disease which causes root and stem rot to soybeans and other legumes in several southern states. The earliest sympt om is yellowing of leaves of individual plants or patches of plants across fields. Leaves of damaged plants usually develop... new soybean disease restricts root development and causes an absence of nitrogen-fixing nodules. Plants are stunted in an irregular pattern that may resemble manganese toxicity, or moisture or potash deficiency. High nematode populations often...

  20. 2014 PROGRAM TO ACCELERATE CLINICAL TRIALS (PACT) RFP The true test for new Alzheimer's drugs is in human clinical trials. Numerous treatments for

    E-Print Network [OSTI]

    Charette, André

    2014 PROGRAM TO ACCELERATE CLINICAL TRIALS (PACT) RFP The true test for new Alzheimer's drugs of these potentially successful drugs have not been brought to human trials because of the increased cost and risk Trials (PACT). The goal of this Request for Proposals (RFP) is to increase the number of innovative drugs

  1. Early Brain Response to Low-Dose Radiation Exposure Involves Molecular Networks and Pathways Associated with Cognitive Functions, Advanced Aging and Alzheimer's Disease

    E-Print Network [OSTI]

    Lowe, Xiu R

    2009-01-01

    map (modified from IPA), all genes that were modulated in the mouse brain by exposure to ionizing radiationmap (modified from IPA), the genes that were modulated in the mouse brain by exposure to ionizing radiation

  2. Early Brain Response to Low-Dose Radiation Exposure Involves Molecular Networks and Pathways Associated with Cognitive Functions, Advanced Aging and Alzheimer's Disease

    E-Print Network [OSTI]

    Lowe, Xiu R

    2009-01-01

    Early brain response to low-dose radiation exposure involvesRunning Title: Low dose radiation affects cognitive functionEarly brain response to low-dose radiation exposure involves

  3. Inhibition of Amyloid-? (A?) Peptide-Binding Alcohol Dehydrogenase-A? Interaction Reduces A? Accumulation and Improves Mitochondrial Function in a Mouse Model of Alzheimer's Disease

    E-Print Network [OSTI]

    Yao, Jun; Du, Heng; Yan, Shiqiang; Fang, Fang; Wang, Chaodong; Lue, Lih-Fen; Guo, Lan; Chen, Doris; Stern, David M.; Moore, Frank J. Gunn; Chen, John Xi; Arancio, Ottavio; Yan, Shirley ShiDu

    2011-02-09

    Amyloid-? (A?) peptide-binding alcohol dehydrogenase (ABAD), an enzyme present in neuronal mitochondria, exacerbates A?-induced cell stress. The interaction of ABAD with A? exacerbates A?-induced mitochondrial and neuronal ...

  4. Mapping Ventricular Expansion and its Clinical Correlates in Alzheimer's Disease and Mild Cognitive Impairment using Multi-Atlas Fluid Image Alignment

    E-Print Network [OSTI]

    Thompson, Paul

    analysis pipeline to analyze 3D changes in ventricular morphology; it provides a highly sensitive (risk genes, treatments) that influence progression. Ventricular expansion appears to provide

  5. A rare case of trigeminal trophic syndrome with an extensive scalp, forehead, and upper eyelid ulceration in a patient with undiagnosed Alzheimer disease

    E-Print Network [OSTI]

    Incel Uysal, Pinar; Artuz, Refika Ferda; Yalcin, Basak Arslan

    2015-01-01

    trophic syndrome treated with thermoplastic occlusion. Thevariable responses [6,8]. Thermoplastic dressings were shown

  6. Mapping Ventricular Expansion and its Clinical Correlates in Alzheimer's Disease and Mild Cognitive Impairment using Multi-Atlas Fluid Image Alignment

    E-Print Network [OSTI]

    Thompson, Paul

    Impairment using Multi-Atlas Fluid Image Alignment Yi-Yu Chou1 , Natasha Leporé1 , Christina Avedissian1 , Sarah K. Madsen1 , Xue Hua1 , Clifford R. Jack, Jr. 2 , Michael W. Weiner3 , Arthur W. Toga1 , Paul M

  7. Neural Substrates of Insulin-Mediated Memory Facilitation in Early Alzheimer's Disease; The Impact of the Apolipoprotein E-Epsilon-4 Allele on Hippocampal Insulin Responses

    E-Print Network [OSTI]

    Thomas, George Patrick, Jr.

    2009-01-10

    -blind, counterbalanced, crossover memory encoding BOLD-based functional MRI study. We also assessed the effects of insulin on non-cognitive brain function with an fMRI motor task, and mean cerebral blood flow with arterial spin-labeled MRI. Last, insulin's effect...

  8. Common Rose Diseases 

    E-Print Network [OSTI]

    Johnk, Janell

    2000-01-11

    is implied. 1. Plant roses in full sun.2. Use drip irrigation or soaker hoses. 3. Water in early morning.4. Selectively prune to open canopy and increase aircirculation. 5. Manage weeds and insects to prevent the spread of viruses. F i ve S te p..., making it moresusceptible to insect problems andother diseases.Management?Prune damaged orinfected canes . The black spot fungusover winters oncanes. Carefulpruning removesdamaged or infectedcanes and slowsdisease development. B lack Spot Rose varieties...

  9. Peanut Diseases Atlas. 

    E-Print Network [OSTI]

    Horne, Wendell C.

    1974-01-01

    Acknowledgments This publication was made possible by a grant from the Texas Peanut Producers Board to the Texas Agricultural Extension Service. This educational support in the area of peanut disease control is appreciated. The author also expresses... appreciation to producers who contributed through the voluntary check-off program and to those Extension staff members and research plant pathologists and nematologists who gave assistance and counsel during the prepara tion of this publication . Peanut...

  10. Inherited risk for common disease

    E-Print Network [OSTI]

    Banava, Helen

    2007-01-01

    Linkage disequilibrium studies have discovered few gene-disease associations for common diseases. The explanation has been offered that complex modes of inheritance govern risk for cancers, cardiovascular and cerebrovascular ...

  11. Vannida Ket Disease Case Presentation

    E-Print Network [OSTI]

    Brutlag, Doug

    -Sachs disease is classically diagnosed by an eye examination or behavior observation. Ganglion cells in the eye

  12. PLANT DISEASES IN SOUTH CAROLINA

    E-Print Network [OSTI]

    Stuart, Steven J.

    INDEX OF PLANT DISEASES IN SOUTH CAROLINA James H. Blake, Ed.D. Director, Home & Garden Information to compile a list of plant diseases occurring on cultivated and native plants in South Carolina. The data or conclusive list of the diseases of plants in South Carolina. New plants as well as new plant pathogens

  13. A Manual of Poultry Diseases

    E-Print Network [OSTI]

    Bell, R. R.; Flowers, A. I.; Grumbles, L. C.; Meinecke, C. F.; Patterson, C. M.; Wormell, B. C.; Hall, C. F.

    1965-01-01

    ............................................ Botlv Defense Against Disease 6 Manifestations of Disease ...................................................... 7 ........ Hatcherv and Breeder Flock Health Management 7 Hatchcrv Management and Sanitation ......... .... ........... 8 Principles... ......................................................... 10 Vaccination No Substitute for Sanitation .................... .. 11 Diseases for 'lIrhich Vaccines Are Available .................... 11 ....................... .................. Acl~ninistration of Vaccines ......... 11 -4 Suggested...

  14. Enhancement of Chaperone-Mediated Protein Folding Through Substrate Protein Interactions with the Groel C-Termini 

    E-Print Network [OSTI]

    Weaver, Jeremy Scott

    2015-04-28

    aggregation is the basis of many neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Creutzfeldt–Jakob disease [115,117-119]. 9 Although Alzheimer’s and cystic fibrosis are very different pathologically, both of these diseases, as well... Folding............................................................................... 1 Troubled Folding and Protein Folding Diseases ................................................. 6 GroEL: the Essential Folding Machine...

  15. EA-0896: Final Environmental Assessment

    Broader source: Energy.gov [DOE]

    Center for Nuclear Medicine Research in Alzheimer's Disease Health Sciences Center- West Virginia University

  16. EA-0896: Finding of No Significant Impact

    Broader source: Energy.gov [DOE]

    Center for Nuclear Medicine Research in Alzheimer's Disease Health Sciences Center- West Virginia University

  17. Development of Graves' disease following radiation therapy in Hodgkin's disease

    SciTech Connect (OSTI)

    Loeffler, J.S.; Tarbell, N.J.; Garber, J.R.; Mauch, P.

    1988-01-01

    Radiation-related thyroid dysfunction is a common occurrence in patients with Hodgkin's disease treated with mantle field radiation. Although chemical and clinical hypothyroidism are most commonly seen, Graves' disease has also been described. We have examined the records of 437 surgically staged patients who received mantle field irradiation between April 1969 and December 1980 to ascertain the frequency of manifestations of Graves' disease. Within this group, seven patients developed hyperthyroidism accompanied by ophthalmic findings typical of those seen in Graves' disease. The actuarial risk of developing Graves' disease at 10 years following mantle irradiation for Hodgkin's disease was 3.3% in female patients and 1% in male patients in this study. The observed/expected ratios were 5.9 and 5.1 for female and male patients, respectively. This observed risk significantly exceeded that seen in the general population.

  18. The etiology of loin disease 

    E-Print Network [OSTI]

    Greeley, Ralph Gordon

    1966-01-01

    treatment has been discovered and the etiology of the disease has never been proven. In South Africa a similar disease, larnsiekte, has been recorded for centuries. In the 1920's intensive research in that country un- covered a chain of conditions... the similarity of lamsiekte and loin disease, and of the phosphorus deficiency that soils of South Africa and the Texas coastal plains have in common. In 1924 he began recommending the routine supplemental feeding of phos- phorus to range cattle (8). Where...

  19. Using Wikipedia to forecast diseases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Molecular Biologist, of the Mathematical and Computational Epidemiology Team at Los Alamos National Laboratory Science Friday Interviews Mining Wikipedia Data to Track Disease...

  20. Laboratory Directed Research and Development Program FY 2009 for Lawrence Berkeley National Laboratory

    E-Print Network [OSTI]

    Hansen, Todd C.

    2010-01-01

    low-dose radiation exposure involves molecular networks and pathways associated with cognitive functions, advanced aging, and Alzheimer’s disease,” Radiation Research

  1. Genomic mosaicism in the human brain

    E-Print Network [OSTI]

    Westra, Jurjen Willem

    2008-01-01

    Zlokovic BV (2008) The blood-brain barrier in health andmosaicism in the human brain ………………………………………. Chapter Threethe Alzheimer’s disease brain ………………………………. Chapter Five DNA

  2. Environmental Contributions to Allergic Disease

    E-Print Network [OSTI]

    Levetin, Estelle

    with increased exposure to air pollution and indoor contaminants such as house dust mites, cockroaches disease is more complex than increased exposure to pollution and allergens and that early childhood of outdoor factors to allergic disease. Influence of Exposure to Pollutants on the Manifestation of Allergic

  3. Publications Fish Disease Diagnosis and

    E-Print Network [OSTI]

    Publications Fish Disease Diagnosis and Basic Fishery Computer Programs The second edition of "Disease Diagnosis and Control in North American Marine Aquaculture," edited by Carl J. Sindermann edition should be a big help to aquaculturists and others involved in the detection, prevention

  4. Occupational Disease in Connecticut, 2014

    E-Print Network [OSTI]

    Oliver, Douglas L.

    Occupational Disease in Connecticut, 2014 This report covers data for 2012 and was prepared under contract for the State of Connecticut Workers' Compensation Commission, John A. Mastropietro, Chairman, as part of the Occupational Disease Surveillance Program, operated in cooperation with the Connecticut

  5. Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence

    E-Print Network [OSTI]

    Brinton, Roberta Diaz

    Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive Bioenergetics Reproductive senescence Alzheimer's disease Estrogen Background: We have previously demonstrated that mitochondrial bioenergetic deficits precede Alzheimer's pathology in the female triple transgenic Alzheimer's (3

  6. Early detection of contagious diseases

    DOE Patents [OSTI]

    Colston, Jr., Billy W. (San Ramon, CA); Milanovich, Fred P. (Lafayette, CA); Estacio, Pedro (Mission San Jose, CA); Chang, John (Walnut Creek, CA)

    2011-08-09

    This invention provides an electronic proximity apparatus and a surveillance method using such an apparatus for alerting individuals that are exposed to a contagious disease. When a person becomes symptomatic and is diagnosed as positive for a given contagious agent, individuals that have recently maintained a threshold proximity with respect to an infected individual are notified and advised to seek immediate medial care. Treatment of individuals in the very early phases of infection (pre-symptomatic) significantly reduces contagiousness of the infected population first exposed to the contagious disease, thus preventing spread of the disease throughout the general population.

  7. A Manual of Poultry Diseases

    E-Print Network [OSTI]

    Hall, C. F.; Bell, R. R.; Clifford, R. L., Jr.; Glass, S. E.; Grimes, J. E.; Grumbles, L. C.; Keahey, E. E.; Wormell, B. C.

    1971-01-01

    ........................................................ 7 Flock Health Management 7 Hatchery Management and Sanitation ............................ 8 Principles of Reasonable Drug Administration ................. .... 9 Drug Administration... Vaccines Are ................................................................... 10 Dangers of Vaccination ........................................................... 10 Vaccination-No Substitute for Sanitation ..... .................... 11 Diseases...

  8. Prudent behaviour accelerates disease transmission

    E-Print Network [OSTI]

    Scarpino, Samuel V; Hebert-Dufresne, Laurent

    2015-01-01

    Infectious diseases often spread faster near their peak than would be predicted given early data on transmission. Despite the commonality of this phenomena, there are no known general mechanisms able to cause an exponentially spreading dis- ease to begin spreading faster. Indeed most features of real world social networks, e.g. clustering1,2 and community structure3, and of human behaviour, e.g. social distancing4 and increased hygiene5, will slow disease spread. Here, we consider a model where individuals with essential societal roles-e.g. teachers, first responders, health-care workers, etc.- who fall ill are replaced with healthy individuals. We refer to this process as relational exchange. Relational exchange is also a behavioural process, but one whose effect on disease transmission is less obvious. By incorporating this behaviour into a dynamic network model, we demonstrate that replacing individuals can accelerate disease transmission. Furthermore, we find that the effects of this process are trivial w...

  9. Diarrheal Disease in Show Swine 

    E-Print Network [OSTI]

    Lawhorn, D. Bruce

    2007-02-27

    from the feces of recovered car- rier pigs or from contaminated premises, trailers or scales. Pigs affected with this disease usually become very sick. This organism infects the cells lining the cecum and spiral colon (the same area as whipworms... disease in show pigs. Infection occurs after pigs ingest microscopic whipworm eggs while rooting or eating in a contaminat- ed environment. Whipworm eggs remain viable for as long as 6 years so contaminated premises are an impor- tant source of infection...

  10. Controlling Diseases on Ornamental Plants. 

    E-Print Network [OSTI]

    Horne, C. Wendell; Johnson, Jerral D.; Walla, Walter J.

    1979-01-01

    on elms and other shade trees. Mushroom-type fu ngal growths appear on trunk, limbs or roots near the soil surface. Rots may be present for several years before mushrooms ap pear. Tree becomes sus ceptible to wi nd damage. Plants may die back..., irises, lilies, narcissus and tulips. ROOT DISEASES Disease Cotton root rot (fungi) Crown gall Mushroom root rot Symptoms Small flowering plants die within a few days. Shrubs and trees die more slowly. Large trees may die within several...

  11. Computational and experimental investigations of forces in protein folding 

    E-Print Network [OSTI]

    Schell, David Andrew

    2005-02-17

    Properly folded proteins are necessary for all living organisms. Incorrectly folded proteins can lead to a variety of diseases such as Alzheimer?s Disease or Bovine Spongiform Encephalitis (Mad Cow Disease). Understanding ...

  12. the heart truth What is heart Disease?

    E-Print Network [OSTI]

    Shen, Jun

    the heart truth® for Women What is heart Disease? Coronary heart disease (CHD) is the most common form of heart disease. Usually referred to simply as "heart disease," it is a disorder of the blood vessels of the heart in which a waxy substance called plaque builds up in the coronary (heart) arteries

  13. 200 Plant Disease / Vol. 87 No. 2200 Disease Notes

    E-Print Network [OSTI]

    Pappu, Hanu R.

    Leaf Curl Begomoviruses from Pakistan. S. L. Shih, W. S. Tsai, and S. K. Green, The Asian Vegetable Disease Research Institute, National Agricultural Research Centre, Islamabad, Pakistan; M. A. Rezaian in Pakistan. One chili sample with leaf curl symptoms was collected in 1998 in Multan (Punjab Province

  14. City of Ada, Minnesota (Utility Company) | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LISTStar Energy LLCLtd Jump

  15. Venkatraman Ramakrishnan, Thomas A. Steitz, Ada E. Yonath, and Ribosome

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefield Municipal GasAdministrationTechnicalTechnicalScience.gov App Find science information

  16. ADA Requirements for Workplace Charging Installation | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i n c i p a l De p u t y A s s iof1 ofDensified Large

  17. with Disabilities Act Requirements Workplace ADA Requirements for Workplace

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on DeliciousMathematics And Statistics » USAJobsMotion to Withdrawp_2p_3o_04302013.xlsxworldPower 2010 1 TDate

  18. MAR 384 -DISEASES OF AQUATIC ORGANISMS (3 credits)

    E-Print Network [OSTI]

    Allam, Bassem

    . Disease management 26. Advances in aquatic animal disease Part I (vaccination, probiotics) 27. Advances

  19. Patching genes to fight disease

    SciTech Connect (OSTI)

    Holzman, D.

    1990-09-03

    The National Institutes of Health has approved the first gene therapy experiments, one of which will try to cure cancer by bolstering the immune system. The applications of such therapy are limited, but the potential aid to people with genetic diseases is great.

  20. Disease Management in Organic Plantings

    E-Print Network [OSTI]

    Isaacs, Rufus

    cooling or proper drying · Clean harvesting and processing equipment · Control insects that may createGard (Gliocladium virens) Blight Ban (Pseudomonas fluorescens) PlantShield (Trichoderma harzianum) Agri Antibiotics for control of bacterial diseases #12;Effect of Trichoderma hamatum (T382) in potting mix

  1. Easy Gardening.....Disease Control 

    E-Print Network [OSTI]

    Johnson, Jerral; Johnson, Jerral

    2009-05-29

    on plant roots and cause stunted plants. The most damaging nematode in the home garden is root knot. It causes galls or knots on susceptible plants such as toma- A good home gardener recognizes the symptoms of plant diseases quickly and takes steps...

  2. Best Management Practices for Equine Disease Prevention 

    E-Print Network [OSTI]

    Scott, Brett D.

    2008-10-06

    AnimalDiseases,Revised1998] SchoolofVeterinaryMedicine,UniversityofWisconsin- Madison. Zoonotic Diseases Tutorial. www.vetmed.wisc.edu/pbs/zoonoses Hammer,Carolyn,2005, Equine Biological Risk Management.IowaStateUniversity. www.cfsph.iastate.edu Griffin...

  3. Karnal Bunt: A Disease of Wheat 

    E-Print Network [OSTI]

    Schuster, Greta; Krausz, Joseph P.; Rush, Charlie

    2002-11-20

    Karnal bunt is a fungal disease that affects wheat, durum wheat and triticale. This publication explains the life cycle of the disease, how it spreads, and methods of control....

  4. Does Drinking Tea Protect Against Cardiovascular Disease?

    E-Print Network [OSTI]

    Thompson, Natasha

    2003-01-01

    Maclure M, Muller JE et al. Tea consumption and mortalityU, Poole C, Arab L. Does Tea Affect Cardiovascular Disease?al. Regular Ingestion of black tea improves brachial artery

  5. MENINGOCOCCAL DISEASE WHAT YOU NEED TO KNOW

    E-Print Network [OSTI]

    Missouri-Rolla, University of

    , coughing and having close social contact (living in the same household) are examples of how this disease

  6. Biomarker for Lung and Inflammatory Diseases

    E-Print Network [OSTI]

    Heydari, Payam

    Biomarker for Lung and Inflammatory Diseases Tech ID: 23381 / UC Case 2012-660-0 BACKGROUND and clinical research. We describe herein a novel biomarker and method of detecting interstitial lung disease have discovered that patients with interstitial lung and intestinal inflammatory diseases, for example

  7. Linkage Disequilibrium Mapping and Parkinson's Disease

    E-Print Network [OSTI]

    Parkinson's Disease Genetics Study Group, Science 279, 1116 (1998); T. Lynch et al., ibid., 278, 1212 (1997Linkage Disequilibrium Mapping and Parkinson's Disease Several investigators (1) have questioned with Parkinson's disease (PD) in four appar- ently unrelated Italian and Greek families, may be a cause

  8. Akt Isoforms in Vascular Disease

    E-Print Network [OSTI]

    Yu, Haixiang; Littlewood, Trevor; Bennett, Martin

    2015-04-28

    aneurysm; eNOS, endothelial nitric oxide synthase;mTOR,mammalian target of rapamycin. 44 1223 331505. . This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). orms in vascular disease, Vascul. Pharmacol. (2015... p85 subunit and a catalytic p110 subunit that directly phosphorylates the ribosomal protein kinase p70s6k [29], the rho family polypeptide Rac [30], the serum and glucocorticoid-induced kinases SGK [31–33], and the serine/threonine kinase Akt [34...

  9. Diseases of Peaches and Plums. 

    E-Print Network [OSTI]

    Johnson, Jerral D.

    1980-01-01

    the possibility of root injury during cultivation as much as possible. Mushroom Root Rot Mushroom root rot is a fungal disease commonly known as "post oak root rot," "shoestring root rot" or "mushroom root rot." It attacks peach, pear, plum, apple and many... trees. Do not replant trees in old orchard sites infested with mushroom root rot. Cotton Root Rot Peach and plum trees die suddenly after show ing first symptoms of wilting. When roots are pulled from the soil, the bark is decayed, and covered...

  10. The Aging Brain: Are two pathologies worse than one? White matter hyperintensities, beta-amyloid, and cognition in normal elderly

    E-Print Network [OSTI]

    Onami, Susan

    2010-01-01

    related with cognition in aging and early Alzheimer disease,is normal, Neurobiology of Aging, 26.4, 9. Jeerakathil, T. ,related with cognition in aging and early Alzheimer disease,

  11. Current Medicinal Chemistry, 2008, 15, 47-60 47 0929-8673/08 $55.00+.00 2008 Bentham Science Publishers Ltd.

    E-Print Network [OSTI]

    Li, Lian

    pathological feature common to many age- related neurodegenerative diseases, including Parkinson's disease-related neurodegenerative diseases, including Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD Publishers Ltd. Aggresome Formation and Neurodegenerative Diseases: Therapeutic Implications J.A. Olzmann1

  12. Therapeutic target for protozoal diseases

    DOE Patents [OSTI]

    Rathore, Dharmendar (Blacksburg, VA); Jani, Dewal (Blacksburg, VA); Nagarkatti, Rana (Blacksburg, VA)

    2008-10-21

    A novel Fasciclin Related Adhesive Protein (FRAP) from Plasmodium and related parasites is provided as a target for therapeutic intervention in diseases caused by the parasites. FRAP has been shown to play a critical role in adhesion to, or invasion into, host cells by the parasite. Furthermore, FRAP catalyzes the neutralization of heme by the parasite, by promoting its polymerization into hemozoin. This invention provides methods and compositions for therapies based on the administration of protein, DNA or cell-based vaccines and/or antibodies based on FRAP, or antigenic epitopes of FRAP, either alone or in combination with other parasite antigens. Methods for the development of compounds that inhibit the catalytic activity of FRAP, and diagnostic and laboratory methods utilizing FRAP are also provided.

  13. 636 IEEE TRANSACTIONS ON IMAGE PROCESSING, VOL. 16, NO. 3, MARCH 2007 A Hybrid EulerianLagrangian Approach

    E-Print Network [OSTI]

    Prince, Jerry L.

    ], and decreased thickness may be related to Alzheimer's disease [8]­[11] and anorexia nervosa [12]. In the heart

  14. Major Oak Diseases and Their Control. 

    E-Print Network [OSTI]

    Johnson, Jerral D.; Appel, David N.

    1984-01-01

    in many areas where oaks are the predominant native tree species. Research shows that much of this mortality is due to disease-causing organisms or disease complexes 10- volving environmental stress and pathogens. FOLIAR DISEASES Anthracnose (Fungus... tor nado, hurricane, severe hail or following a period of mechanical activity around oak trees. Heavy equip- ment working around trees can create large wounds. When this occurs, insects are attracted to the site and may be carrying the wilt...

  15. Diseases of Small Grains in Texas. 

    E-Print Network [OSTI]

    Atkins, I. M.; Futrell, M. C.

    1958-01-01

    Diseases - of SMALL GRAINS in cooperation with the UNITED STATES DEPARTMENT OF AGRICULTURE TEXAS AGRICULTURAL EXPERIMENT STATION R. D. LEWIS, DIRECTOR. COLLEGE STATIOKJ. TEXAS DIGEST CONTENTS 1 Diseases of small grains are important factors... and international signif- icance. The fall infection, winter survival and spring increase in South Texas of airborne pathogens, such as the cereal rusts, may endanger the small grain crops throughout Texas and other states. Diseases of wheat, which consistently...

  16. Mathematical Model Applications to Disease and Homeland ...

    E-Print Network [OSTI]

    Mathematical Model Applications to Disease and Homeland Security The events of ... but have no data or reliable information that would help in the planning or ...

  17. HANFORD THYROID DISEASE STUDY FINAL REPORT

    E-Print Network [OSTI]

    HANFORD THYROID DISEASE STUDY FINAL REPORT Study Management Team Scott Davis, Ph.D., Principal Gilman, Jennifer Sporleder, Jan Kikuchi, Bill Mullin, Liza Noonan, Chuck Wiggins, Belen Gallardo

  18. "Artificial" brains, electrical grids, and disease modeling:...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science discoveries unveiled "Artificial" brains, electrical grids, and disease modeling: Los Alamos science discoveries unveiled September 15 The event is an opportunity for...

  19. Disease management Applying Stylet Oil, Sulforix or

    E-Print Network [OSTI]

    Isaacs, Rufus

    1 Disease management Applying Stylet Oil, Sulforix or Armicarb now to vines with powdery mildew will reduce disease pressure next year. Do not apply Sulforix to sulfur-sensitive grapes. Bunch rots are best controlled by leaf pulling, but application of Fungastop may help reduce sour rot. Insect management Low

  20. What You Should Know About Plant Diseases

    E-Print Network [OSTI]

    Horne, C. Wendell; Smith, Harlan E.

    1962-01-01

    lodge, the grain is shrivelled and yields are low. The disease movement is shown in figure 6. " Seedling Disease ig. 7. See, caused b - -.-!.. ~. &> dling dise; y a comp' L , ase of cot1 lex of mic 11, *L^ -1. .fore its el tter it emf...

  1. The implications of human metabolic network topology for disease comorbidity

    E-Print Network [OSTI]

    of different (and often disease-causing) genetic and epigenetic variations are not restricted but may spread, certain diseases, such as diabetes and obesity, or Gaucher disease and Parkinson disease, often cooccurThe implications of human metabolic network topology for disease comorbidity D.-S. Lee* , J. Park

  2. Disease Prevention in the Home Garden. 

    E-Print Network [OSTI]

    Johnson, Jerral D.

    1980-01-01

    . 12. Rotation. Avoid soil disease buildup. ?13. Insect control. Prevent virus spread. 14. Proper harvesting. Avoid storage decay. 15. Sanitation. Prevent buildup of diseased plant tissue in garden. 16. Fungicide application. Control diseases should...H to approximately 5.2; 10 Ibs. of sulfur per 1000 sq . ft. d rops the pH .5. Examp le: Ori- ginal pH 7.5; desired pH 5.5; 40 Ibs. of sulfur requ ired to adjust pH 3. Ring rot Bacterium I nfected seed pieces Introduction of Rotation and sanitation Equipment...

  3. Behavioral impulsivity and hallucinations : insights from Parkinson's disease

    E-Print Network [OSTI]

    Ashourian, Paymon

    2011-01-01

    Parkinson's disease (PD) is an age-related degenerative disease of the brain, characterized by motor, cognitive, and psychiatric symptoms. Neurologists and neuroscientists now understand that several symptoms of the disease, ...

  4. Study of collagen structure in canine myxomatous mitral valve disease 

    E-Print Network [OSTI]

    Hadian, Mojtaba

    2009-01-01

    Myxomatous mitral valve disease (MMVD) is the single most common acquired cardiac disease of dogs, and is a disease of significant veterinary importance. It also bears close similarities to mitral valve prolapse in humans ...

  5. Epidemiology and evolution of Marek’s Disease virus 

    E-Print Network [OSTI]

    Atkins, Katherine E.

    2010-01-01

    Marek’s disease (MD) is an oncogenic disease affecting chickens and is estimated to cost the worldwide poultry industry $1-2 billion annually. The causative agent of MD, Marek’s disease virus (MDV), provides a ...

  6. HLB in Argentina: a New Disease Outbreak

    E-Print Network [OSTI]

    2014-01-01

    Vol. 1 (2014) HLB in Argentina: a New Disease Outbreak Outi,E. 6 SENASA, Bs. As. Argentina MAGyP Bs. As INTA Montecarlo,Paraná, 300 km away from Argentina’s Northeastern border. In

  7. Metabolomics reveals metabolic biomarkers of Crohn's disease

    SciTech Connect (OSTI)

    Jansson, J.K.; Willing, B.; Lucio, M.; Fekete, A.; Dicksved, J.; Halfvarson, J.; Tysk, C.; Schmitt-Kopplin, P.

    2009-06-01

    The causes and etiology of Crohn's disease (CD) are currently unknown although both host genetics and environmental factors play a role. Here we used non-targeted metabolic profiling to determine the contribution of metabolites produced by the gut microbiota towards disease status of the host. Ion Cyclotron Resonance Fourier Transform Mass Spectrometry (ICR-FT/MS) was used to discern the masses of thousands of metabolites in fecal samples collected from 17 identical twin pairs, including healthy individuals and those with CD. Pathways with differentiating metabolites included those involved in the metabolism and or synthesis of amino acids, fatty acids, bile acids and arachidonic acid. Several metabolites were positively or negatively correlated to the disease phenotype and to specific microbes previously characterized in the same samples. Our data reveal novel differentiating metabolites for CD that may provide diagnostic biomarkers and/or monitoring tools as well as insight into potential targets for disease therapy and prevention.

  8. Management of cotton seedling disease complexes 

    E-Print Network [OSTI]

    Fichtner, Scott Michael

    2001-01-01

    The objective of this research was to evaluate combinations of approaches for the management of seedling diseases of cotton caused by soilborne pathogens, including the use of host resistance. Over 200 cotton lines were ...

  9. MFR PAPER 1208 Minchinia nelsoni (MSX) Disease

    E-Print Network [OSTI]

    of the disease in each of these areas has been thoroughly stud- 22 ied and reported (Haskin et aI., 1965; Andrews, 1966, 1968; Rosenfield and Sindermann, 1966; Andrews and Wood, 1967; Couch and Rosenfield, 1968; Ford

  10. Is chytridiomycosis an emerging disease in Asia?

    E-Print Network [OSTI]

    Brown, Rafe M.

    2011-01-01

    Museum of Natural Sciences, Raleigh, North Carolina, United States of America, 26Museo Nacional de Ciencias Naturales, Madrid, Spain Abstract The disease chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis (Bd), has caused dramatic... Museum of Natural Sciences, Raleigh, North Carolina, United States of America, 26Museo Nacional de Ciencias Naturales, Madrid, Spain Abstract The disease chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis (Bd), has caused dramatic...

  11. How should environmental stress affect the population dynamics of disease?

    E-Print Network [OSTI]

    Holt, Robert D.

    in pollution (Khan 1990), malnutrition (Beck & Levander 2000) and thermal stress from climate change (Harvell and disease in natural populations. Keywords Disease, dynamics, host, infectious, model, pollution, population

  12. ATTACHMENT 1: HANFORD SITE CHRONIC BERYLLIUM DISEASE PREVENTION...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    : HANFORD SITE CHRONIC BERYLLIUM DISEASE PREVENTION PROGRAM (CBDPP) COMMITTEE CHARTER The Hanford Site Chronic Beryllium Disease Prevention Program (CBDPP) Committee is established...

  13. Disease-Specific Symptoms and Health-Related Quality of Life in Children and Adolescents with Inflammatory Bowel Disease 

    E-Print Network [OSTI]

    Vaughan-Dark, Chelsea Ann

    2013-07-17

    This study assesses generic and disease-specific Health-Related Quality of Life (HRQOL) in children and adolescents with Inflammatory Bowel Disease (IBD). More specifically, the purpose of the study is to address the relationship between disease...

  14. Photo-environment affects disease progression in bacterial artificial chromosome (BAC) Huntington s disease mouse model

    E-Print Network [OSTI]

    HUEI-BIN, WANG,

    2015-01-01

    OF CALIFORNIA Los Angeles Photo-environment affects diseaseABSTRACT OF THE THESIS Photo-environment affects diseaseshow that inappropriate photo-environment such as constant

  15. Tracking Living Cells as They Differentiate in Real Time

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    these projects will target Alzheimer's disease, macular degeneration of the retina in diabetes, and mitochondrial diseases in children. In addition, specific processes like protein...

  16. L. Martini (Eds.) Progress in Brain Research, Vol. 182

    E-Print Network [OSTI]

    Brinton, Roberta Diaz

    on Alzheimer's disease risk and therapy Victor W. Henderson1,Ã and Roberta Diaz Brinton2 1 Departments-containing hormone therapy increases dementia risk and probably does not improve Alzheimer's disease symptoms earlier estrogen exposures. Some observational results imply that effects of hormone therapy on Alzheimer

  17. Transgenic Mouse Model of Chronic Beryllium Disease

    SciTech Connect (OSTI)

    Gordon, Terry

    2009-05-26

    Animal models provide powerful tools for dissecting dose-response relationships and pathogenic mechanisms and for testing new treatment paradigms. Mechanistic research on beryllium exposure-disease relationships is severely limited by a general inability to develop a sufficient chronic beryllium disease animal model. Discovery of the Human Leukocyte Antigen (HLA) - DPB1Glu69 genetic susceptibility component of chronic beryllium disease permitted the addition of this human beryllium antigen presentation molecule to an animal genome which may permit development of a better animal model for chronic beryllium disease. Using FVB/N inbred mice, Drs. Rubin and Zhu, successfully produced three strains of HLA-DPB1 Glu 69 transgenic mice. Each mouse strain contains a haplotype of the HLA-DPB1 Glu 69 gene that confers a different magnitude of odds ratio (OR) of risk for chronic beryllium disease: HLA-DPB1*0401 (OR = 0.2), HLA-DPB1*0201 (OR = 15), HLA-DPB1*1701 (OR = 240). In addition, Drs. Rubin and Zhu developed transgenic mice with the human CD4 gene to permit better transmission of signals between T cells and antigen presenting cells. This project has maintained the colonies of these transgenic mice and tested the functionality of the human transgenes.

  18. Chronic beryllium disease: Diagnosis and management

    SciTech Connect (OSTI)

    Rossman, M.D.

    1996-10-01

    Chronic beryllium disease is predominantly a pulmonary granulomatosis that was originally described in 1946. Symptoms usually include dyspnea and cough. Fever, anorexia, and weight loss are common. Skin lesions are the most common extrathoracic manifestation. Granulomatous hepatitis, hypercalcemia, and kidney stones can also occur. Radiographic and physiologic abnormalities are similar to those in sarcoidosis. While traditionally the pathologic changes included granulomas and cellular interstitial changes, the hallmark of the disease today is the well-formed granuloma. Immunologic studies have demonstrated a cell-mediated response to beryllium that is due to an accumulation of CD4{sup +} T cells at the site of disease activity. Diagnosis depends on the demonstration of pathologic changes (i.e., granuloma) and evidence that the granuloma was caused by a hypersensitivity to beryllium (i.e., positive lung proliferative response to beryllium). Using these criteria, the diagnosis of chronic beryllium disease can now be made before the onset of clinical symptoms. Whether, with early diagnosis, the natural course of this condition will be the same as when it was traditionally diagnosed is not known. Currently, corticosteroids are used to treat patients with significant symptoms or evidence of progressive disease. 21 refs.

  19. Global disease monitoring and forecasting with Wikipedia

    SciTech Connect (OSTI)

    Generous, Nicholas; Fairchild, Geoffrey; Deshpande, Alina; Del Valle, Sara Y.; Priedhorsky, Reid; Salathé, Marcel

    2014-11-13

    Infectious disease is a leading threat to public health, economic stability, and other key social structures. Efforts to mitigate these impacts depend on accurate and timely monitoring to measure the risk and progress of disease. Traditional, biologically-focused monitoring techniques are accurate but costly and slow; in response, new techniques based on social internet data, such as social media and search queries, are emerging. These efforts are promising, but important challenges in the areas of scientific peer review, breadth of diseases and countries, and forecasting hamper their operational usefulness. We examine a freely available, open data source for this use: access logs from the online encyclopedia Wikipedia. Using linear models, language as a proxy for location, and a systematic yet simple article selection procedure, we tested 14 location-disease combinations and demonstrate that these data feasibly support an approach that overcomes these challenges. Specifically, our proof-of-concept yields models with up to 0.92, forecasting value up to the 28 days tested, and several pairs of models similar enough to suggest that transferring models from one location to another without re-training is feasible. Based on these preliminary results, we close with a research agenda designed to overcome these challenges and produce a disease monitoring and forecasting system that is significantly more effective, robust, and globally comprehensive than the current state of the art.

  20. Global disease monitoring and forecasting with Wikipedia

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Generous, Nicholas; Fairchild, Geoffrey; Deshpande, Alina; Del Valle, Sara Y.; Priedhorsky, Reid; Salathé, Marcel

    2014-11-13

    Infectious disease is a leading threat to public health, economic stability, and other key social structures. Efforts to mitigate these impacts depend on accurate and timely monitoring to measure the risk and progress of disease. Traditional, biologically-focused monitoring techniques are accurate but costly and slow; in response, new techniques based on social internet data, such as social media and search queries, are emerging. These efforts are promising, but important challenges in the areas of scientific peer review, breadth of diseases and countries, and forecasting hamper their operational usefulness. We examine a freely available, open data source for this use: accessmore »logs from the online encyclopedia Wikipedia. Using linear models, language as a proxy for location, and a systematic yet simple article selection procedure, we tested 14 location-disease combinations and demonstrate that these data feasibly support an approach that overcomes these challenges. Specifically, our proof-of-concept yields models with up to 0.92, forecasting value up to the 28 days tested, and several pairs of models similar enough to suggest that transferring models from one location to another without re-training is feasible. Based on these preliminary results, we close with a research agenda designed to overcome these challenges and produce a disease monitoring and forecasting system that is significantly more effective, robust, and globally comprehensive than the current state of the art.« less

  1. 788 Plant Disease / Vol. 83 No. 9 Snow mold diseases are caused by fungi

    E-Print Network [OSTI]

    Hsiang, Tom

    788 Plant Disease / Vol. 83 No. 9 Snow mold diseases are caused by fungi that grow and attack limit the activity and number of com- petitors and antagonists of snow mold fungi, and allow these pathogens to mo- nopolize the nutrient-rich but weakened plant tissues (42). Most snow mold fungi that have

  2. An immuno-epidemiological model for Johne's disease in cattle

    E-Print Network [OSTI]

    Martcheva, Maia

    An immuno-epidemiological model for Johne's disease in cattle Maia Martcheva1 Email: maia's disease in dairy cattle, this paper illustrates a novel way to link a within-host model for Mycobacterium reproduction model. Introduction Johne's disease (JD) in dairy cattle is a chronic infectious disease

  3. Vascular pathology in the aged human brain

    E-Print Network [OSTI]

    Grinberg, Lea Tenenholz; Thal, Dietmar Rudolf

    2010-01-01

    vascular pathology, and the AD brain. Neurology 65: 259–265brospinal ?uid from the rat brain. Acta Neuropathol (Berl)and Alzheimer’s disease in the brains of elderly individuals

  4. Nanofluidic biosensing for beta-amyloid detection 

    E-Print Network [OSTI]

    Chou, I-Hsien

    2009-05-15

    A nanofluidic biosensor using surface-enhanced Raman scattering (SERS) was developed to detect the ?-amyloid (A?) protein, one of the biomarkers of Alzheimer’s disease (AD). Recent studies have indicated that investigating ...

  5. Despite its role in assembly, methionine 35 is not necessary for amyloid ?-protein toxicity

    E-Print Network [OSTI]

    Maiti, Panchanan

    An important component of the pathologic process underlying Alzheimer’s disease is oxidative stress. Met[superscript 35] in amyloid ?-protein (A?) is prone to participating in redox reactions promoting oxidative stress, ...

  6. Melatonin, oxidative stress and the aging brain

    E-Print Network [OSTI]

    Bondy, SC; Sharman, EH

    2010-01-01

    markers in healthy aging and Alzheimer’s disease.Neurobiol Aging. 8. Kim R, Emi M, Tanabe K. Role ofFree radicals and brain aging. Clin Geriatr Med. 2004;20:

  7. 2011LandesBioscience. Donotdistribute.

    E-Print Network [OSTI]

    Shorter, James

    Alzheimer disease, Huntington disease, Parkinson disease and amyo- trophic lateral sclerosis (ALS). Although, dopaminer- gic neurons are preferentially affected in Parkinson disease, whereas striatal neu- rons sclerosis (ALS, also known as Lou Gehrig's disease) is a debilitating and universally fatal

  8. Alzheimer's Alzheimer's & Dementia 4 (2008) 5153-5168

    E-Print Network [OSTI]

    Wurtman, Richard

    2008-01-01

    to phosphocholine). The actions of DHA aere reproduced by eicosapentaenoic acid, another omega-3 compound

  9. ATP Release and Signaling via P2Y Receptors Regulate Cardiac Fibroblast Phenotype and Activity

    E-Print Network [OSTI]

    Lu, David

    ADA PSB 603 P2 (P2Y 2 ) Cx(43,45) ATP collagen ?-SMA PAI-1from ventricular CFs in vitro via Cx hemi-channels and thatCVD cardiovascular disease Cx connexin DAG diacyl glycerol

  10. Oxidative Modifications and Down-regulation of Ubiquitin Carboxyl-terminal Hydrolase L1 Associated with Idiopathic

    E-Print Network [OSTI]

    Li, Lian

    with Idiopathic Parkinson's and Alzheimer's Diseases* Received for publication, December 23, 2003 Published, JBC of Texas Health Science Center, San Antonio, Texas 78229 Alzheimer's disease (AD) and Parkinson's disease's disease (AD)1 and Parkinson's disease (PD) are the two most common neurodegenerative disorders in humans

  11. interdisciplinary Glyphosate, pathways to modern diseases II

    E-Print Network [OSTI]

    Seneff, Stephanie

    rashes, depression, and nutrient deficiencies. Usually, but not always, a strict gluten-free diet caninterdisciplinary Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance, and, more generally, gluten intolerance, is a growing problem worldwide, but especially in North

  12. ISSUE 58 APRIL 2009 Will coeliac disease

    E-Print Network [OSTI]

    Rambaut, Andrew

    ISSUE 58 APRIL 2009 Will coeliac disease always mean gluten-free? Pen-pushers Meet the winning is to deliver a free, Darwin-inspired experiment to every schoolchild in the country. For primary schools, we of the Wellcome Trust Wellcome News Wellcome News is published four times a year and is available free of charge

  13. Centers for Disease Control and Prevention (CDC)

    E-Print Network [OSTI]

    and Terrorism and Director of Global Health Activities for the Division of Environmental Hazards and Health based environmental health assessments #12;Government Agencies Visited · The United States AgencyCenters for Disease Control and Prevention (CDC) National Center for Environmental Health CDC

  14. Injury vs Disease Lifestyles of pathogens

    E-Print Network [OSTI]

    Nowak, Robert S.

    of plant disease Nematodes alone cost ~$100 billions worldwide In the US, yearly cost ~ $15 billions #12 of temperature 3 Days After #12;#12;Effects of wind Mostly dispersal of pathogens In some cases, wind can prevent the development of new infections because it dries the surface of plants Wind can cause injury

  15. Injury vs Disease Lifestyles of pathogens

    E-Print Network [OSTI]

    Nowak, Robert S.

    In the US, yearly cost ~ $15 billions #12;4/29/2015 15 Impacts of plant disease In a worldwide scale 27 of wind Mostly dispersal of pathogens In some cases, wind can prevent the development of new infections because it dries the surface of plants Wind can cause injury (mechanical abrasion) Effects of temperature

  16. Genetically Determined Height and Coronary Artery Disease

    E-Print Network [OSTI]

    Nelson, Christopher P.; Hamby, Stephen E.; Saleheen, Danish; Hopewell, Jenna C.; Zeng, Lingyao; Assimes, Themistocles L.; Kanoni, Stavroula; Willenborg, Christina; Burgess, Stephen; Amouyel, Philippe; Anand, Sonia; Blankenberg, Stefan; Boehm, Bernhard O.; Clarke, Robert J.; Collins, Rory; Dedoussis, George; Farrall, Martin; Franks, Paul W.; Groop, Leif; Hall, Alistair S.; Hamsten, Anders; Hengstenberg, Christian; Hovingh, G. Kees; Ingelsson, Erik; Kathiresan, Sekar; Kee, Frank; König, Inke R.; Kooner, Jaspal; Lehtimäki, Terho; März, Winifred; McPherson, Ruth; Metspalu, Andres; Nieminen, Markku S.; O'Donnell, Christopher J.; Palmer, Colin N.A.; Peters, Annette; Perola, Markus; Reilly, Muredach P.; Ripatti, Samuli; Roberts, Robert; Salomaa, Veikko; Shah, Svati H.; Schreiber, Stefan; Siegbahn, Agneta; Thorsteinsdottir, Unnur; Veronesi, Giovani; Wareham, Nicholas J.; Willer, Cristen J.; Zalloua, Pierre A.; Erdmann, Jeanette; Deloukas, Panos; Watkins, Hugh; Schunkert, Heribert; Danesh, John; Thompson, John R.; Samani, Nilesh J.

    2015-04-23

    of Tampere, Tampere (T.L.), and the Division of Cardiology, Department of Medicine, Helsinki University Central Hospital (M.S.N.), Department of Chronic Disease Prevention, National Institute for Health and Welfare (M.P., V.S.), and Hjelt Institute The New...

  17. 3301DEVELOPMENT AND DISEASE RESEARCH ARTICLE INTRODUCTION

    E-Print Network [OSTI]

    Gibson, Matt

    smooth muscle cells (SMC) and SM pathology is associated with several diseases, including asthma, lung the urinary bladder, and a failure of this activity causes `functional' flow impairment leading to urinary tract may be an important primary cause of functional obstruction and hydronephrosis. Between mouse

  18. Treatment of Anthrax Disease Frequently Asked Questions

    SciTech Connect (OSTI)

    Judd, Kathleen S.; Young, Joan E.; Lesperance, Ann M.; Malone, John D.

    2010-05-14

    This document provides a summary of Frequently Asked Questions (FAQs) on the treatment of anthrax disease caused by a wide-area release of Bacillus anthracis spores as an act bioterrorism. These FAQs are intended to provide the public health and medical community, as well as others, with guidance and communications to support the response and long-term recovery from an anthrax event.

  19. ISSUE 55 JULY 2008 Genes and disease

    E-Print Network [OSTI]

    Rambaut, Andrew

    ISSUE 55 JULY 2008 FUNDING Genes and disease In this issue... FUNDING AND UPDATES 2­5 Project building, in Kenya, South Africa, Uganda and elsewhere in Africa (see page 5). The largest ever study. The Institute will devote a large part of its high-throughput genotyping pipeline, headed by Dr Panos Deloukas

  20. DISEASES OF AQUATIC ORGANISMS Dis Aquat Org

    E-Print Network [OSTI]

    Harvell, Catherine Drew

    and disease in Mexico J. R. Ward1,*, K. L. Rypien1 , J. F. Bruno2 , C. D. Harvell1 , E. Jordán-Dahlgren3 , K Sciences, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3300, USA 3

  1. Disease Prediction Models and Operational Readiness

    SciTech Connect (OSTI)

    Corley, Courtney D.; Pullum, Laura L.; Hartley, David M.; Benedum, Corey M.; Noonan, Christine F.; Rabinowitz, Peter M.; Lancaster, Mary J.

    2014-03-19

    INTRODUCTION: The objective of this manuscript is to present a systematic review of biosurveillance models that operate on select agents and can forecast the occurrence of a disease event. One of the primary goals of this research was to characterize the viability of biosurveillance models to provide operationally relevant information for decision makers to identify areas for future research. Two critical characteristics differentiate this work from other infectious disease modeling reviews. First, we reviewed models that attempted to predict the disease event, not merely its transmission dynamics. Second, we considered models involving pathogens of concern as determined by the US National Select Agent Registry (as of June 2011). Methods: We searched dozens of commercial and government databases and harvested Google search results for eligible models utilizing terms and phrases provided by public health analysts relating to biosurveillance, remote sensing, risk assessments, spatial epidemiology, and ecological niche-modeling, The publication date of search results returned are bound by the dates of coverage of each database and the date in which the search was performed, however all searching was completed by December 31, 2010. This returned 13,767 webpages and 12,152 citations. After de-duplication and removal of extraneous material, a core collection of 6,503 items was established and these publications along with their abstracts are presented in a semantic wiki at http://BioCat.pnnl.gov. Next, PNNL’s IN-SPIRE visual analytics software was used to cross-correlate these publications with the definition for a biosurveillance model resulting in the selection of 54 documents that matched the criteria resulting Ten of these documents, However, dealt purely with disease spread models, inactivation of bacteria, or the modeling of human immune system responses to pathogens rather than predicting disease events. As a result, we systematically reviewed 44 papers and the results are presented in this analysis.

  2. Free membership Agriculture Alzheimer Antibiotics

    E-Print Network [OSTI]

    Kowalczykowski, Stephen C.

    Astrophysics Atmosphere Bacteria Behavioral sciences Biochemistry Biology Blood Brain Cancer Cells Chemistry of Service | Privacy Policy | Contact Home Events Groups Jobs Articles insciences.org - Human DNA

  3. Laterality of Motor Symptom Onset, Disease Progression, and Cognition in Parkinson's Disease

    E-Print Network [OSTI]

    Chau, Phuong My

    2010-08-31

    The current study examined whether laterality of initial motor symptom onset (left-sided onset vs. right-sided onset) in Parkinson's disease (PD) would predict the pattern and/or severity of cognitive deficits measured at ...

  4. Disease resistance and performance of blended populations of creepi 

    E-Print Network [OSTI]

    Abernathy, Scott David

    1999-01-01

    Plant diseases are a major problem on creeping bentgrass greens and can significantly decrease putting quality. Blended populations comprised of two or more cultivars within the same species have been utilized to decrease disease development...

  5. Goal-directed Behaviour & Apathy in Parkinson's Disease 

    E-Print Network [OSTI]

    Cox, Simon

    2009-11-26

    Apathy has been described as a highly-prevalent symptom of Parkinson's disease that has a significant effect upon quality of life, even when the motor symptoms of the disease are taken into account.

  6. Characterization of a Drosophila model of Huntington's disease

    E-Print Network [OSTI]

    Lee, Wyan-Ching Mimi

    2006-01-01

    Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation ...

  7. Mycosphaerella species causing leaf disease in South African Eucalyptus plantations

    E-Print Network [OSTI]

    Mycosphaerella species causing leaf disease in South African Eucalyptus plantations Gavin C. HUNTER Eucalyptus plantations provide an important source of hardwood for forestry industries, worldwide. Several species of Mycosphaerella are associated with a destructive Eucalyptus leaf disease known

  8. Women and Heart Disease: Neglected Directions for Future Research

    E-Print Network [OSTI]

    Barrett-Connor, Elizabeth

    2009-01-01

    009-9110-0 Women and Heart Disease: Neglected Directions forage 65, women have less heart disease than men. For many1980s showed a lower risk of heart attacks in postmenopausal

  9. Endemic models for the spread of infectious diseases with arbitrarily ...

    E-Print Network [OSTI]

    SIAM (#1) 1035 1999 Jan 20 12:53:14

    2000-10-03

    have general length distributions and disease survival functions, the different time ..... In order to describe the duration of the various stages and the related disease ...... Approaches to Problems in Resource Management and Epidemiology, ...

  10. Role of the hedgehog signalling pathway in inflammatory bowel disease 

    E-Print Network [OSTI]

    Lees, Charles William

    2009-01-01

    Introduction. The inflammatory bowel diseases (IBD), Crohn’s disease (CD) and ulcerative colitis (UC), are common in Western Europe (200-400 cases /100,000) and associated with substantial morbidity, although mortality ...

  11. (See reverse side) Information about Meningococcal Disease and Vaccination

    E-Print Network [OSTI]

    Dennett, Daniel

    is infected and is coughing or sneezing. Who is at most risk for getting meningococcal disease? High

  12. Exploring Disease Transmission On Networks with Winfried Just

    E-Print Network [OSTI]

    Just, Winfried

    the relevant contact network, depends on the particular disease. Think of the flu vs. a computer virus vs of disease transmission Infectious diseases are caused by pathogens (such as viruses, bacteria, fungi identical. Such models can be embodied in computer code as agent-based models. Winfried Just and Ying Xin

  13. Disease transmission by cannibalism: rare event or common occurrence?

    E-Print Network [OSTI]

    Antonovics, Janis

    Disease transmission by cannibalism: rare event or common occurrence? Volker H. W. Rudolf Cannibalism has been documented as a possible disease transmission route in several species, including humans. However, the dynamics resulting from this type of disease transmission are not well understood. Using

  14. Neurobiology of Disease Parkin Directly Modulates 26S Proteasome Activity

    E-Print Network [OSTI]

    Lübbert, Hermann

    . Introduction Parkinson's disease (PD) is a major neurodegenerative disease characterized by the degenerationNeurobiology of Disease Parkin Directly Modulates 26S Proteasome Activity Ji Won Um,1 Eunju Im,1-University Bochum, D-44780 Bochum, Germany, and 4Biofrontera Bioscience GmbH, D-51377 Leverkusen, Germany Parkinson

  15. Neuroinflammation in Parkinson's Disease Animal Models: A Cell Stress Response

    E-Print Network [OSTI]

    Sulzer, David

    in a wide range of toxin-based, inflammatory and genetic Parkinson's disease animal models. KeywordsNeuroinflammation in Parkinson's Disease Animal Models: A Cell Stress Response or a Step neuroin- flammatory processes are exacerbated in Parkinson's disease, including glial- mediated reactions

  16. Pluripotent stem cells in neurodegenerative and neurodevelopmental diseases

    E-Print Network [OSTI]

    Bellugi, Ursula

    such as Parkinson's disease and amyotrophic lateral sclerosis where patients' cells have been successfully repro the end-stage of the disease. Mouse models provide a means to mimic human genetic forms of diseases. Owingto tech- nical challenges, species differences and genetic background, even neurologic

  17. Emerging infectious diseases of plants: pathogen pollution, climate change

    E-Print Network [OSTI]

    Schweik, Charles M.

    Emerging infectious diseases of plants: pathogen pollution, climate change and agrotechnology, Boston, MA 02115, USA Emerging infectious diseases (EIDs) pose threats to conservation and public health a series of emerging plant diseases. We include EIDs of cultivated and wild plants, some of which

  18. Understanding Equine Strangles: Signs of Disease, Management and Prevention1

    E-Print Network [OSTI]

    Watson, Craig A.

    in 1251. The infection is highly contagious in horse populations and can recur on farms with previous outbreaks of the disease. It is one of the most commonly diagnosed contagious diseases of the horse signs of infection. Complications of Disease Fortunately, although strangles is highly contagious

  19. A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN

    E-Print Network [OSTI]

    A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN BY R. R. RUCKER, W. J. WHIPPLE, J. R A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN By R. R. Rucker, W. J. Whipple, J. R. Parvin and C. A #12;A CONTAGIOUS DISEASE OF SALMON, POSSIBLY OF VIRUS ORIGIN By R. R. Rucker,! Fishery Research

  20. Identification of Early Interstitial Lung Disease in Smokers from the

    E-Print Network [OSTI]

    Identification of Early Interstitial Lung Disease in Smokers from the COPDGene Study George R interstitial lung disease (ILD) on chest computed tomographic (CT) scans. Materials and Methods: The CT scans: Early interstitial lung disease; CT scan; smoker. ªAUR, 2010 I diopathic pulmonary fibrosis (IPF

  1. Investigation of the phenotypic and genotypic determinants of disease susceptibility and progression in Crohn’s Disease 

    E-Print Network [OSTI]

    Phillips, Anne Mairead

    2011-07-05

    The inflammatory bowel diseases (IBD), encompassing Crohn’s disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders of the gastrointestinal tract. Their aetiology is not fully understood but is thought ...

  2. An investigation of the genetic determinants of succeptibility and disease behavoir in early onset Inflammatory Bowel Disease in Scottish children. 

    E-Print Network [OSTI]

    Russell, Richard K

    2008-01-01

    A series of investigations examining the importance of genetic factors in the development of the inflammatory bowel diseases (IBD) namely Crohn’s disease (CD), Ulcerative Colitis (UC) and Indeterminate Colitis (IC) has ...

  3. THE INSTITUTES AT NORTHWESTERN MEDICINE FOR TRANSLATIONAL

    E-Print Network [OSTI]

    Chisholm, Rex L.

    neurodegenerative diseases, what are their genetic implications, and how can they be treated? · What degeneration (CBD), Parkinson's disease (PD), Lewy body dementia (LBD), motor neuron disease (MND MEDICINE COGNITIVE NEUROLOGY AND ALZHEIMER'S DISEASE CENTER #12;THE INSTITUTES AT NORTHWESTERN MEDICINE

  4. Impact of Palivizumab on RSV Hospitalizations for Children with Hemodynamically Significant Congenital Heart Disease

    E-Print Network [OSTI]

    Chang, Ruey-Kang R.; Chen, Alex Y.

    2010-01-01

    in infants with congenital heart disease. Pediatrics 114:children with congenital heart disease. The Cardiac StudySigni?cant Congenital Heart Disease Ruey-Kang R. Chang •

  5. Smoking and Ischemic Heart Disease Disparities Between Studies, Genders, Times, and Socioeconomic Strata

    E-Print Network [OSTI]

    Leistikow, Bruce N.

    2009-01-01

    predictors of coronary heart disease among women. Americanon the risk for coronary heart disease even stronger thanx Smoking and Ischemic Heart Disease Disparities Between

  6. Personalized medicine strategies for managing patients with Parkinsonism and cognitive deficits

    E-Print Network [OSTI]

    Wurtman, Richard

    and behavioral symptoms may arise from Parkinson's disease [PD] per se, but they can also characterize Lewy Body dementia [LBD] or concurrent Parkinson's and Alzheimer's diseases [PD & AD]. Abnormalities of both movement with parkinsonism, Alzheimer's disease and Huntington's disease (HD) and by the variety of regional and temporal

  7. Understanding diseases at a molecular level

    SciTech Connect (OSTI)

    Rosev, Tatjana K [Los Alamos National Laboratory

    2008-01-01

    A group of scientists at Los Alamos National Laboratory in 2008 successfully pioneered a microscope able to track protein-sized, hard to see particles in three dimensions. The 3D Tracking Microscope, designed and developed by James H. Werner, Guillaume A. Lessard, Nathan Wells and Peter M. Goodwin of LANL's Center for Integrated Nanotechnologies, won a 2008 R&D 100 award. The team's invention is a unique confocal 3D tracking microscope capable of following the motion of nanometer-sized objects, such as individual molecules, quantum dots, organic fluorophores and single green fluorescent proteins as they zoom through three-dimensional space at rates faster than many intracellular transport processes. The 3D tracking microscope can follow the transport of nanometer-sized particles at micrometer per second rates. This enables researchers to follow individual protein, ribonucleic acid (RNA), or deoxyribonucleic acid (DNA) motion throughout the full three-dimensional volume of a cell to discover the path a particular biomolecule takes, the method it employs to get there and the specific proteins it may be interacting with along the way. In addition to applications in molecular spectroscopy and materials research, the 3D tracking microscope is a powerful tool primarily in the fields of cellular biology and biomedical research, Werner said. 'The 3D tracking microscope will advance our understanding of the molecular basis and kinetics of many diseases, such as cancer, diabetes, or muscular dystrophy,' he said. 'We anticipate the microscope will become a valuable weapon in the arsenal of biomedical researchers who are fighting to find cures for cancer, heart disease and other protein or DNA-based diseases.'

  8. Respiratory disease in Utah coal miners

    SciTech Connect (OSTI)

    Rom, W.N.; Kanner, R.E.; Renzetti, A.D. Jr.; Shigeoka, J.W.; Barkman, H.W.; Nichols, M.; Turner, W.A.; Coleman, M.; Wright, W.E.

    1981-04-01

    Two hundred forty-two Utah underground coal miners volunteered to participate in a respiratory disease study. They were an older group (mean, 56 years of age) and had spent a mean of 29 years in the coal-mining industry. The prevalence of chronic bronchitis was 57%, and that of coal worker's pneumoconiosis, 25%; only one worker had progressive massive fibrosis. Significant impairment of pulmonary function was found among those with a history of cigarette smoking. Chronic bronchitis or coal worker's penumoconiosis among nonsmokers did not impair pulmonary function. There was a significant association among the nonsmokers between increasing exposure to coal dust and coal worker's pneumoconiosis, but not for changes in pulmonary function. Coal mine dust had a significant influence in causing the symptom complex of chronic cough and sputum production, and coal worker's pneumoconiosis.

  9. Respiratory disease in Utah coal miners

    SciTech Connect (OSTI)

    Rom, W.N.; Kanner, R.E.; Renzetti, A.D. Jr.; Shigeoka, J.W.; Barkman, H.W.; Nichols, M.; Turner, W.A.; Coleman, M.; Wright, W.E.

    1981-04-01

    Two hundred forty-two Utah underground coal miners volunteered to participate in a respiratory disease study. They were an older group (mean, 56 years of age) and had spent a mean of 29 years in the coal-mining industry. The prevalence of chronic bronchitis was 57%, and that of coal worker's pneumoconiosis, 25%; only one worker had progressive massive fibrosis. Significant impairment of pulmonary function was found among those with a history of cigarette smoking. Chronic bronchitis or coal worker's pneumoconiosis among nonsmokers did not impair pulmonary function. There was a significant association among the nonsmokers between increasing exposure to coal dust and coal worker's pneumoconiosis, but not for changes in pulmonary function. Coal mine dust had a significant influence in causing the symptom complex of chronic cough and sputum production, and coal worker's pneumoconiosis.

  10. Chronic Beryllium Disease Prevention Program Report

    SciTech Connect (OSTI)

    Lee, S

    2012-03-29

    This document describes how Lawrence Livermore National Laboratory (LLNL) meets the requirements and management practices of federal regulation 10 CFR 850, 'Chronic Beryllium Disease Prevention Program (CBDPP).' This revision of the LLNL CBDPP incorporates clarification and editorial changes based on lessons learned from employee discussions, observations and reviews of Department of Energy (DOE) Complex and commercial industry beryllium (Be) safety programs. The information is used to strengthen beryllium safety practices at LLNL, particularly in the areas of: (1) Management of small parts and components; and (2) Communication of program status to employees. Future changes to LLNL beryllium activities and on-going operating experience will be incorporated into the program as described in Section S, 'Performance Feedback.'

  11. Automated diagnostic kiosk for diagnosing diseases

    DOE Patents [OSTI]

    Regan, John Frederick; Birch, James Michael

    2014-02-11

    An automated and autonomous diagnostic apparatus that is capable of dispensing collection vials and collections kits to users interesting in collecting a biological sample and submitting their collected sample contained within a collection vial into the apparatus for automated diagnostic services. The user communicates with the apparatus through a touch-screen monitor. A user is able to enter personnel information into the apparatus including medical history, insurance information, co-payment, and answer a series of questions regarding their illness, which is used to determine the assay most likely to yield a positive result. Remotely-located physicians can communicate with users of the apparatus using video tele-medicine and request specific assays to be performed. The apparatus archives submitted samples for additional testing. Users may receive their assay results electronically. Users may allow the uploading of their diagnoses into a central databank for disease surveillance purposes.

  12. Optical detection dental disease using polarized light

    DOE Patents [OSTI]

    Everett, Matthew J. (Livermore, CA); Colston, Jr., Billy W. (Livermore, CA); Sathyam, Ujwal S. (Livermore, CA); Da Silva, Luiz B. (Danville, CA); Fried, Daniel (San Francisco, CA)

    2003-01-01

    A polarization sensitive optical imaging system is used to detect changes in polarization in dental tissues to aid the diagnosis of dental disease such as caries. The degree of depolarization is measured by illuminating the dental tissue with polarized light and measuring the polarization state of the backscattered light. The polarization state of this reflected light is analyzed using optical polarimetric imaging techniques. A hand-held fiber optic dental probe is used in vivo to direct the incident beam to the dental tissue and collect the reflected light. To provide depth-resolved characterization of the dental tissue, the polarization diagnostics may be incorporated into optical coherence domain reflectometry and optical coherence tomography (OCDR/OCT) systems, which enables identification of subsurface depolarization sites associated with demineralization of enamel or bone.

  13. PERIORAL BIOMECHANICS, KINEMATICS, AND ELECTROPHYSIOLOGY IN PARKINSON'S DISEASE

    E-Print Network [OSTI]

    Chu, Shin Ying

    2010-11-21

    This investigation quantitatively characterized the orofacial biomechanics, labial kinematics, and associated electromyography (EMG) patterns in individuals with Parkinson's disease (PD) as a function of anti-PD medication ...

  14. Structure of the Newcastle disease virus hemagglutinin-neuraminidase...

    Office of Scientific and Technical Information (OSTI)

    of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a four-helix bundle stalk Citation Details In-Document Search Title: Structure of the Newcastle...

  15. Proteins' Amazing Origami Powers: Insight for Potential Disease...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Senior Writer, Office of Science What are the key facts? Better knowledge of protein folding could in turn provide more insight into the diseases associated with malformed...

  16. Genomics of emerging infectious disease: A PLoS collection.

    E-Print Network [OSTI]

    Eisen, Jonathan A; MacCallum, Catriona J

    2009-01-01

    Origins and evolutionary genomics of the 2009 swine-originan Infectious Diseases Genomics Project predict and preventRavel J (2009) The role of genomics in the identification,

  17. Psoriasis disease severity affects patient satisfaction with treatment

    E-Print Network [OSTI]

    Korman, Neil J; Zhao, Yang; Lu, Jackie; Tran, Mary Helen

    2015-01-01

    among patients with psoriasis and psoriatic arthritis in thefindings from the National Psoriasis Foundation surveys,J. Mechanism of disease: psoriasis. N Engl J Med. 2009;361(

  18. Recombinant herpes simplex virus useful for treating neoplastic disease

    DOE Patents [OSTI]

    Whitley, Richard J.; Roizman, Bernard

    2010-06-29

    Recombinant herpes simplex viruses comprising DNA encoding cytokines and methods for treating neoplastic diseases using the inventive recombinant viruses are disclosed.

  19. AND NUCLEAR MEDICINE; DIAGNOSIS; DISEASES; GAMMA CAMERAS; GENETICS...

    Office of Scientific and Technical Information (OSTI)

    Converting energy to medical progress nuclear medicine NONE 62 RADIOLOGY AND NUCLEAR MEDICINE; DIAGNOSIS; DISEASES; GAMMA CAMERAS; GENETICS; NUCLEAR MEDICINE; PATIENTS; RADIATION...

  20. Bacteria Associated With Colitis and Inflammatory Bowel Disease

    E-Print Network [OSTI]

    Ye, Jingxiao

    2009-01-01

    bowel diseases: antibiotics, probiotics, and prebiotics."clinical trial of probiotics (Lactobacillus johnsonii, LA1)Besides antibiotics, probiotics might also be a potential

  1. 2012 ALS User Meeting Awards

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in areas that include Alzheimer's and Parkinson's disease, antibiotic resistance and food crop improvements. Klaus Halbach was a senior staff scientist at LBNL who pioneered the...

  2. Do changes in traditional coronary heart disease risk factors over time explain the association between socio-economic status and coronary heart disease?

    E-Print Network [OSTI]

    Franks, Peter; Winters, Paul C; Tancredi, Daniel J; Fiscella, Kevin A

    2011-01-01

    case-control study. Heart 2009, Franks P, Tancredi DJ,status in coronary heart disease risk estimation. Ann Famstatus and coronary heart disease risk prediction. JAMA

  3. Discrete Molecular Dynamics Study of wild-type and Arctic-mutant (E22G) A16-22

    E-Print Network [OSTI]

    Stanley, H. Eugene

    - structure 2 #12;Introduction Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson, Bethesda, MD 20892 Harvard-Partners Center for Genetics and Genomics, Brigham & Women's Hospital, Boston that amyloid -protein (A) forms assemblies with potent neurotoxic prop- erties that cause Alzheimer's disease

  4. Fish oil can help reduce deaths from heart disease,

    E-Print Network [OSTI]

    Shen, Jun

    Fish oil can help reduce deaths from heart disease, according to new evidence reports announced- ute to heart disease. The review also found other evidence indicating that fish oil can help lower in knowledge." Continued, page 2... Evidence Reports Confirm Benefits of Fish Oil Elizabeth Yetley, PhD Joins

  5. Harnessing plasticity to understand learning and treat disease

    E-Print Network [OSTI]

    Kilgard, Michael P.

    Harnessing plasticity to understand learning and treat disease Michael P. Kilgard The University, USA A large body of evidence suggests that neural plasticity contributes to learning and disease. Recent studies sug- gest that cortical map plasticity is typically a transient phase that improves

  6. Epidemiology / pidmiologie Climate change and plant diseases in Ontario

    E-Print Network [OSTI]

    Boland, Greg J.

    Epidemiology / Épidémiologie Climate change and plant diseases in Ontario G.J. Boland, M.S. Melzer in Ontario will significantly affect the occurrence of plant diseases in agriculture and forestry management plans. Adaptations in agriculture and forestry have been occurring in Ontario for over 100 years

  7. Original article Lentivirus-induced interstitial lung disease

    E-Print Network [OSTI]

    Boyer, Edmond

    Original article Lentivirus-induced interstitial lung disease: pulmonary pathology in sheep a chronic disease in sheep affecting, among other organs, the lungs. Interstitial pneumonitis is similar the pathological features of lungs of sheep naturally infected with visna-maedi virus with the results obtained

  8. Lung Disease in Pediatrics: is it all in the Genes?

    E-Print Network [OSTI]

    Lung Disease in Pediatrics: is it all in the Genes? Jay K. Kolls, M.D.Jay K. Kolls, M.D. Chair with CF do worse than other? #12;· Outcomes are better at CF centers · There is huge variation in lung with the same mutation do worse than others? · Modifier genes ­ lung disease ­ Tgfb1 ­ Irfd1 ­ neutrophil

  9. Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease

    E-Print Network [OSTI]

    Sulzer, David

    State Psychiatric Institute, New York City, NY 10032, USA Parkinson's disease arises from geneticMultiple hit hypotheses for dopamine neuron loss in Parkinson's disease David Sulzer Departments features. Although many genetic mutations have been suggested as causes or risk factors for Parkinson

  10. Ash dieback disease www.forestry.gov.uk/planthealth

    E-Print Network [OSTI]

    Ash dieback disease www.forestry.gov.uk/planthealth Pest Alert Distribution In Britain, most of the outbreaks of ash dieback disease in the natural environment are confined to East Anglia and Kent, although a small number of outlying cases have been confirmed in northeast England and Scotland. Common ash

  11. Chronic Beryllium Disease Prevention Environment, Safety, Health, and Quality Division

    E-Print Network [OSTI]

    Wechsler, Risa H.

    Chronic Beryllium Disease Prevention Program Environment, Safety, Health, and Quality Division SLAC-I-730-0A09M-001-R003 24 September 2013 #12;Publication Data This document was developed by the Beryllium program and published by ESHQ Publishing. Document Title: Chronic Beryllium Disease Prevention Program

  12. Economic Consideration of Mitigation of Foreign Animal Disease Introduction *

    E-Print Network [OSTI]

    McCarl, Bruce A.

    Economic Consideration of Mitigation of Foreign Animal Disease Introduction * Levan Elbakidze, Bruce A. McCarl Department of Agricultural Economics National Center for Foreign Animal and Zoonotic Disease Defense (FAZDD), Texas A&M University, College Station TX, USA The economic implications

  13. Research Fund for the Prevention and Treatment of Kidney Disease

    E-Print Network [OSTI]

    Weber, David J.

    and economic costs associated with these diseases. UMMC accommodates one million patient visits a year With a reputation for innovation and technical and surgical excellence, the UMSOM Division of Transplantation is one global cost for treatment of kidney disease in terms of dialysis and transplantation over the next decade

  14. Asbestos-related pulmonary disease in boilermakers

    SciTech Connect (OSTI)

    Demers, R.Y.; Neale, A.V.; Robins, T.; Herman, S.C. )

    1990-01-01

    Boilermakers are skilled building tradesmen who construct, repair, and dismantle boilers. The present study reports on the evaluation of members of a Michigan boilermaker's union for the presence of signs and symptoms of chronic pulmonary disease. Study variables included standardized evaluations of chest x-ray findings, pulmonary function testing, physical examination, and respiratory symptoms. An overall participation rate of 69% was achieved. A non-participant survey identified no significant differences between participants and non-participants in dyspnea, cough, age, or smoking history. Among participants with greater than 20 years experience in the trade, the mean FVC was 91% of predicted; the FEV1 was 86% of predicted; 25% showed at least a 1/0 profusion of interstitial markings on chest x-ray; 30% had bilateral pleural abnormalities; and 52% had audible inspiratory rales on physical examination. Forced vital capacity and forced expiratory volume at one second both decreased with years in the trade. Chest x-ray findings of interstitial fibrosis and pleural plaques were related to ten or more years in the trade, as were respiratory symptoms of pulmonary rales, wheeze, and dyspnea.

  15. Career Timelines Extracted from Wikipedia ada10fdi@student.lu.se

    E-Print Network [OSTI]

    of their work experience. We do this by connecting persons to professions through analysis of part of professions to work from. The baseline list of professions is obtained through first creating a graph where, it is determined to be a profession and is added to the list. We chose Occupation as the root node since Profession

  16. WINKENWERDER ADA COMPLIANCE On March 5, 2012, a work order was submitted to FSWorks

    E-Print Network [OSTI]

    Brown, Sally

    response was received: From: Thomas Berg Sent: Tuesday, October 09, 2012 8:05 AM To: Ming K. Jue Cc: Elliott Nutt Subject: RE: Winken-Warder (156057) Ming, I visited the site yesterday with Elliott Nutt to be considered for funding as a capital project next biennium [201315]. Thomas W. Berg Thomas W. Berg RA, LEED

  17. A restudy of the cylindrical amphoras from the seventh-century Yassi Ada shipwreck 

    E-Print Network [OSTI]

    Van Alfen, Peter Gerritt

    1995-01-01

    F.H. van Doorninck, Jr.'s recent work on the piriform amphoras recovered from the 11th c. A.D. shipwreck at Serge Liman, Turkey, has shown that the volume capacity of the amphoras in liters correlate to weight capacities ...

  18. Ada Numerica (1998), pp. 51-150 Cambridge University Press, 1998 Nonlinear approximation

    E-Print Network [OSTI]

    DeVore, Ronald

    1998-01-01

    References 146 1. Nonlinear approximation: an overview The fundamental problem of approximation theory functionals applied to the target function are known. This information is then used to construct by certain smoothness conditions which are significantly weaker than required in the linear theory. Emphasis

  19. Adapting ADA Architectural Design Knowledge to Product Design: Groundwork for a Function Based Approach 

    E-Print Network [OSTI]

    Sangelkar, Shraddha Chandrakant

    2011-10-21

    , generate user activity and product function association rules that can be applied to the universal design of products. Proposed research activities are to identify thirty existing universal products and compare with its typical version to identify... promise in using the International Classification of Functioning, Disability and Health (ICF) lexicon to model user limitation. The actionfunction diagram provides a structured way to approach a problem in the early stage of design. The rules generated...

  20. ADA/SCADA RTU protocol based on the 3-layer UCA model

    SciTech Connect (OSTI)

    Adamo, V.P.

    1995-12-31

    This paper describes an implementation of a DA/SCADA RTU communication protocol based on the 3-layer reference model for wide area networks specified in the Utility Communications Architecture (UCA) VL1.0. This protocol is based on the following international standards: EIA-232-D, High-level Data Link Control (HDLC) [ISO/IEC 3309], and Manufacturing Message Specification (MMS) [ISO/IEC 95061]. A description of the HDLC frame structure used in this implementation is provided. This includes a description of the extended transparency option for Start/Stop transmission, commonly referred to as {open_quotes}asynchronous HDLC{close_quotes}. This option allows for the transmission of HDLC frames using inexpensive asynchronous communication hardware. The data link topology described in this paper is an unbalanced, point-to-multipoint topology consisting of one primary, or, master station, and multiple secondary, or remote, stations. The data link operates in the Normal Response Mode (NRM). In this mode a secondary station may initiate transmissions only as a result of receiving explicit permission to do so from the primary station. The application layer protocol described in this paper is an implementation of the Manufacturing Message Specification (MMS). The MMS device model, or Virtual Manufacturing Device (VMD), for a DA/SCADA Remote Terminal Unit is provided. The current VMD model provides a view of common RTU data types, plus, A/C Input (ACI) data including phasor magnitude and mean readings, harmonics, and overcurrent alarm information.

  1. Long Range Campus Development Plan ADA The abbreviation for Americans with Disabilities Act.

    E-Print Network [OSTI]

    Lawrence, Rick L.

    by Grant Street, and east by South 6th Avenue. Cogeneration The use of a heat engine or power station Montana Hall, Hamilton Hall, Lewis Hall, Traphagen Hall, Herrick Hall, Linfield Hall, the Heating Plant

  2. A Variational Model for Oligomer-Formation Process of GNNQQNY Peptide from Yeast Prion Protein Sup35

    E-Print Network [OSTI]

    Zhang, Yang

    , Parkinson's disease, type II diabetes, and transmissible spongiform encephalopathies (1). Despite for the Alzheimer's disease, latrepirdine (Dimebon; Pfizer, Groton, CT) and tarenflurbil (Flurizan; Myriad Genetics Many human neurodegenerative diseases are associated with the aggregation of insoluble amyloid

  3. DOI 10.1007/s00018-013-1530-y Cellular and Molecular Life Sciences Cell. Mol. Life Sci. (2014) 71:18651879

    E-Print Network [OSTI]

    Gardner, Rich

    2014-01-01

    's disease, Parkinson's disease, Abstract The accumulation and aggregation of misfolded proteins Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis. Over 15 degenerative diseases by genetic mutations, synthesis errors, or post- synthesis damage caused by physical or chemical stresses

  4. Endogenously Nitrated Proteins in Mouse Brain: Links to Neurodegenerative Colette A. Sacksteder,, Wei-Jun Qian,,| Tatyana V. Knyushko, Haixing Wang,| Mark H. Chin, Goran Lacan,@

    E-Print Network [OSTI]

    Smith, Desmond J.

    proteins that have been identified are involved in Parkinson's disease, Alzheimer's disease, or otherEndogenously Nitrated Proteins in Mouse Brain: Links to Neurodegenerative Disease Colette A Laboratory, Richland, Washington 99352, and Department of Human Genetics and Department of Molecular

  5. Assessment Framework Report Volume 2: Research Profiles

    E-Print Network [OSTI]

    Rambaut, Andrew

    teams from across the UK to investigate the causes of Alzheimer's disease, Parkinson's disease and motor associated with Parkinson's disease. Research led by Dr J Mark Cooper (UCL) in collaboration with Professors genetic cause of Parkinson's, a mutation in the

  6. Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK

    E-Print Network [OSTI]

    Sulzer, David

    and 2 Department of Neurology, Center for Parkinson's Disease and Other Movement Disorders, Columbia Disease, polyglutamine disease (CAG repeat), and Parkinson disease (10). Ã To whom correspondence shouldAutophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and m

  7. Commercial Pecans: Controlling Rosette, Diseases and Zinc Deficiency 

    E-Print Network [OSTI]

    Lee, Thomas A.; Krausz, Joseph P.

    2006-04-13

    to be healthy and vigor- ous and for nut quality and yield to be satisfactory, producers must establish sound disease-management programs. Producers can pre- vent losses from diseases and insuff_i cient zinc by implementing ef_fective grove management... fall. Although the foliage is mature and no longer susceptible to the scab fun- gus, the shucks surrounding the nuts are immature and vulnerable to late-season infections. Factors inf_l uencing disease development As you develop a spray program...

  8. PrPSc complexity in different forms of Creutzfeldt-Jakob disease identified using biochemical approaches 

    E-Print Network [OSTI]

    Choi, Young Pyo

    2010-01-01

    Transmissible spongiform encephalopathies (TSEs) or prion diseases are a group of fatal neurodegenerative diseases affecting humans and animal species. Prion diseases are characterized by the conversion of the host encoded ...

  9. HUMAN DISEASE FROM RADON EXPOSURES: THE IMPACT OF ENERGY CONSERVATION IN RESIDENTIAL BUILDINGS

    E-Print Network [OSTI]

    Budnitz, R.J.

    2011-01-01

    Buildings H M N DISEASE FROM RADON EXPOSURES: U A THE IMPACTVent 78-6 HUMAN DISEASE FROM RADON EXPOSURES: THE IMPACT OFof conservation measures on radon levels, and the disease

  10. Tackling Africa's chronic disease burden: from the local to the global

    E-Print Network [OSTI]

    de-Graft Aikins, Ama; Unwin, Nigel; Agyemang, Charles; Allotey, Pascale; Campbell, Catherine; Arhinful, Daniel

    2010-04-19

    Abstract Africa faces a double burden of infectious and chronic diseases. While infectious diseases still account for at least 69% of deaths on the continent, age specific mortality rates from chronic diseases as a whole are actually higher in sub...

  11. Speaker for Nov. 1 Lecture to Discuss Deadliest Viral Diseases...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    These studies have led her from the U.S. Centers for Disease Control and Prevention to Lyon, France, where she was instrumental in designing, constructing and making operational a...

  12. Interpreting noncoding genetic variation in complex traits and human disease

    E-Print Network [OSTI]

    Kellis, Manolis

    Association studies provide genome-wide information about the genetic basis of complex disease, but medical research has focused primarily on protein-coding variants, owing to the difficulty of interpreting noncoding ...

  13. Striatal origin of the pathologic beta oscillations in Parkinson's disease

    E-Print Network [OSTI]

    Boyden, Edward Stuart

    Enhanced oscillations at beta frequencies (8–30 Hz) are a signature neural dynamic pathology in the basal ganglia and cortex of Parkinson's disease patients. The mechanisms underlying these pathological beta oscillations ...

  14. Superspreading and the impact of individual variation on disease emergence

    E-Print Network [OSTI]

    Getz, Wayne M.

    1 Superspreading and the impact of individual variation on disease emergence Supplementary.................................................................................................................................. 4 1.1 Factors contributing to variation in infectiousness 2.2.2 Parameter estimation from mean and proportion of zeros .................................... 8

  15. Introduction Multiple sclerosis (MS) is an inflammatory disease of the

    E-Print Network [OSTI]

    Strominger, Jack L.

    Introduction Multiple sclerosis (MS) is an inflammatory disease of the CNS affecting 0 the frequency of relapses by 30% in relapsing-remitting multiple sclerosis (MS) patients. In the present study

  16. Computational and experimental studies of collagen and related diseases

    E-Print Network [OSTI]

    Yang, Chen, M. Eng. Massachusetts Institute of Technology

    2005-01-01

    Collagen is the most abundant proteins in mammals, and collagen degradation is a process that may be associated with many diseases. In this research we use collagen-like peptides that model both cleavage and noncleavage ...

  17. A PROTEOMIC STUDY OF OXIDATIVE STRESS IN ALCOHOLIC LIVER DISEASE 

    E-Print Network [OSTI]

    Newton, Billy W.

    2010-01-16

    Alcoholic steatosis (AS) is the initial pathology associated with early stage alcoholic liver disease and is characterized by the accumulation of fat in the liver. AS is considered clinically benign as it is reversible, ...

  18. Peptide immunotherapy in models of allergic airways disease 

    E-Print Network [OSTI]

    MacKenzie, Karen Joan

    2011-11-25

    Allergen-reactive CD4+ T cells are implicated in the pathogenesis of allergic disease. Peptide immunotherapy (PIT) involves therapeutic administration of short immunodominant peptides from within the protein allergen to ...

  19. Ecologic niche modeling and spatial patterns of disease transmission

    E-Print Network [OSTI]

    Peterson, A. Townsend

    2006-12-01

    Ecologic niche modeling (ENM) is a growing field with many potential applications to questions regarding the geography and ecology of disease transmission. Specifically, ENM has the potential to inform investigations concerned ...

  20. Biological studies and characterization of the High Plains Disease pathogen 

    E-Print Network [OSTI]

    Mirabile, Joanna

    2001-01-01

    High Plains Disease (HPD), which is a recently recognized affliction causing up to 80% yield losses in corn and wheat, has been suspected to be of viral origin, however no clear evidence existed to validate this claim. ...

  1. Parenting styles, peer influences, and adolescent cardiovascular disease risk factors 

    E-Print Network [OSTI]

    Tramm, Amy Bishop

    2000-01-01

    Parenting and friendship styles were examined as indicators for obesity and risk of cardiovascular disease in 54 Texas adolescents. This study investigated the relationship between parental and peer influences on obesity ...

  2. Cognitive change in motor neurone disease : evidence of orbitofrontal dysfunction 

    E-Print Network [OSTI]

    McNeill, Ewan

    2006-01-01

    This study examines the presence of cognitive changes in amyotrophic lateral sclerosis (ALS), a subtype of motor neurone disease. Past research has shown executive dysfunction in patients with ALS and frontotemporal ...

  3. Marek’s disease virus pathogenesis and latency 

    E-Print Network [OSTI]

    Hunter, Gillian

    2012-11-30

    Marek’s Disease virus (MDV) is a highly contagious, widespread and persistent neoplastic ?-herpesvirus causing extensive lymphoblastic tumours in chickens. The virus is shed in feather dust and spread through inhalation. ...

  4. Nature of language impairment in motor neurone disease 

    E-Print Network [OSTI]

    Rewaj, Phillipa Jane

    2014-07-01

    Background: Language impairment associated with Motor Neurone Disease (MND) has been documented since the late 19th century, yet little is understood about the pervasiveness or nature of these deficits. The common clinical ...

  5. GUIDE FOR IDENTIFICATION OF IMPORTANT DISEASES IN STRAWBERRY IN CALIFORNIA

    E-Print Network [OSTI]

    Ullrich, Paul

    GUIDE FOR IDENTIFICATION OF IMPORTANT DISEASES IN STRAWBERRY IN CALIFORNIA Anthracnose Angular Leaf on the underside of the leaf is one of the most recognizable signs of bacterial infection on strawberry leaves

  6. Disease marketing and patient coping : a research study

    E-Print Network [OSTI]

    Lau, Hew Mun

    2012-01-01

    BACKGROUND: There is a high prevalence of disease marketing actions in the United States that are targeted towards patients with chronic illness. However, no study has assessed the direct effects of these marketing actions ...

  7. Transforming South–South Technical Support to Fight Noncommunicable Diseases

    E-Print Network [OSTI]

    Shakow, Aaron D.A.

    At the UN High-Level Meeting on non-communicable diseases (NCD) in September 2011, each member state was challenged to create a multisectoral national policy and plan for the prevention and control of non-communicable ...

  8. Polyamine pathway contributes to the pathogenesis of Parkinson disease

    E-Print Network [OSTI]

    Lewandowski, Nicole M.

    The full complement of molecular pathways contributing to the pathogenesis of Parkinson disease (PD) remains unknown. Here we address this issue by taking a broad approach, beginning by using functional MRI to identify ...

  9. Interactive Whole-Heart Segmentation in Congenital Heart Disease

    E-Print Network [OSTI]

    Pace, Danielle Frances

    We present an interactive algorithm to segment the heart chambers and epicardial surfaces, including the great vessel walls, in pediatric cardiac MRI of congenital heart disease. Accurate whole-heart ...

  10. Food, Poverty and Epidemic Disease, Edinburgh: 1840-1850 

    E-Print Network [OSTI]

    MacGillivray, Neil

    2004-01-01

    The thesis first examines the link between nutrition and disease, focusing on the poor of Edinburgh during the 184Os, a time of economic depression and food shortage. The development of nutritional science and the level ...

  11. Host nutrition and infectious disease: an ecological view

    E-Print Network [OSTI]

    Smith, Val H.; Jones II, Tyrees P.; Smith, Marilyn S.

    2005-06-01

    Nutrition is typically discussed in terms of maintaining a proper diet and avoiding nutrient deficiency diseases. However, nutrition can also be viewed from an ecological standpoint: mammalian hosts and their pathogens ...

  12. Strategic Global Alliances in Vaccine Development and Disease Control

    E-Print Network [OSTI]

    Schnaufer, Achim

    Strategic Global Alliances in Vaccine Development and Disease Control Dr Sadhana Sharma BBSRC · UK veterinary vaccinology network · Global veterinary vaccinology alliance #12;3 COORDINATION public engagement on bioscience What we do: #12;"Global Strategic Alliances for the Coordination

  13. Timing of testing and treatment for asymptomatic diseases

    SciTech Connect (OSTI)

    K?rk?zlar, Eser; Faissol, Daniel M.; Griffin, Paul M.; Swann, Julie L.

    2010-07-01

    Many papers in the medical literature analyze the cost-effectiveness of screening for diseases by comparing a limited number of a priori testing policies under estimated problem parameters. However, this may be insufficient to determine the best timing of the tests or incorporate changes over time. In this paper, we develop and solve a Markov Decision Process (MDP) model for a simple class of asymptomatic diseases in order to provide the building blocks for analysis of a more general class of diseases. We provide a computationally efficient method for determining a cost-effective dynamic intervention strategy that takes into account (i) the results of the previous test for each individual and (ii) the change in the individual’s behavior based on awareness of the disease. We demonstrate the usefulness of the approach by applying the results to screening decisions for Hepatitis C (HCV) using medical data, and compare our findings to current HCV screening recommendations.

  14. Medicating race : heart disease and durable preoccupations with difference

    E-Print Network [OSTI]

    Pollock, Anne, 1975-

    2007-01-01

    This dissertation is an examination of intersections of race, pharmaceuticals, and heart disease over the course of the 20th century and today. Each of these parts has had a dynamic history, and when they are invoked ...

  15. Mechanisms of disease pathogenesis in Spinal Muscular Atrophy 

    E-Print Network [OSTI]

    Mutsaers, Chantal

    2014-06-28

    Low levels of survival motor neuron (SMN) protein cause the autosomal recessive neurodegenerative disease spinal muscular atrophy (SMA), through mechanisms that are poorly defined. SMN protein is ubiquitously expressed, ...

  16. Field Diseases of the Sweet Potato in Texas. 

    E-Print Network [OSTI]

    Taubenhaus, J. J. (Jacob Joseph)

    1919-01-01

    the diseases of the sweet potato. Instead, the corrosive sub: mate treatment should be resorted to because of its efficiency as a fun$ cide arid because of the stimulating effect which it exerts on the resul ing sprouts. After carefully selecting the seed... sweet potatoes for shape (Fig. 1) and discarding all the "shoe strings" (Fig. 2), they should be disinfected with corrosive sublimate solution. This treatment aims at killing the spores of the various disease producing organisms which adhere...

  17. Engineering disease resistance with pectate lyase-like genes

    DOE Patents [OSTI]

    Vogel, John; Somerville, Shauna

    2005-03-08

    A mutant gene coding for pectate lyase and homologs thereof is provided, which when incorporated in transgenic plants effect an increased level disease resistance in such plants. Also is provided the polypeptide sequence for the pectate lyase of the present invention. Methods of obtaining the mutant gene, producing transgenic plants which include the nucleotide sequence for the mutant gene and producing improved disease resistance in a crop of such transgenic plants are also provided.

  18. Characterization of Resistance to Black Spot Disease of Rosa Spp. 

    E-Print Network [OSTI]

    Dong, Qianni

    2014-12-01

    Young-Ki Jo Joshua Yuan Head of Department, Daniel R. Lineberger December 2014 Choose an item. Choose an item. Major Subject: Horticulture Copyright.... These trials typically last 2-3 years to ensure sufficient disease pressure to properly assess the resistance of the plants (Carlson-Nilsson, 2000; Noack, 2003; Shupert, 2005). Lab based detached leaf 4 assay (DLA) is a tool for observing disease...

  19. The inflammatory response in transgastric surgery: gastric content leak leads to localized inflammatory response and higher adhesive disease

    E-Print Network [OSTI]

    2010-01-01

    response and higher adhesive disease Sonia L. Ramamoorthy Æin?ammatory markers, adhesive disease, and morbidity.cantly higher rate of adhesive disease in the SG compared

  20. Thoracic irradiation in Hodgkin's disease: Disease control and long-term complications

    SciTech Connect (OSTI)

    Tarbell, N.J.; Thompson, L.; Mauch, P. (Harvard Medical School, Boston, MA (USA))

    1990-02-01

    A total of 590 patients with Stage IA-IIIB Hodgkin's disease received mantle irradiation at the Joint Center for Radiation Therapy between April 1969 and December 1984 as part of their initial treatment. Recurrence patterns as well as pulmonary, cardiac and thyroid complications were analyzed. Pulmonary recurrence was more frequently seen in patients with large mediastinal adenopathy (LMA); 11% of patients with LMA recurred in the lung in contrast to 3.1% with small or no mediastinal disease, p = 0.003. Hilar involvement, when corrected for size of mediastinal involvement, was not predictive of lung relapse. Patients with LMA also had a high rate of nodal relapse above the diaphragm (40%) following radiation therapy (RT) alone as compared to similarly treated patients with small or no mediastinal adenopathy (6.5%), p less than 0.0001. This risk of nodal recurrence was greatly reduced (4.7%) for LMA patients receiving combined radiation therapy and chemotherapy (CMT), p less than 0.0001. Sixty-seven patients (11%) with hilar or large mediastinal involvement received prophylactic, low dose, whole lung irradiation. No decrease in the frequency of lung recurrence was seen with the use of whole lung irradiation. Radiation pneumonitis was seen in 3% of patients receiving radiation therapy alone. In contrast, the use of whole lung irradiation was associated with a 15% risk of pneumonitis, p = 0.006. The risk of pneumonitis was also significantly increased with the use of chemotherapy (11%), p = 0.0001. Cardiac complications were uncommon with pericarditis being the most common complication (2.2%). Thyroid dysfunction was seen in 25% of patients and appeared to be age-related. These data suggest that the long-term complications of mantle irradiation are uncommon with the use of modern radiotherapeutic techniques.

  1. Holdover inoculum of Pseudomonas syringae pv. alisalensis from broccoli raab causes disease in subsequent plantings

    E-Print Network [OSTI]

    Cintas, N A; Koike, S T; Bunch, R A; Bull, C T

    2006-01-01

    alisalensis from Broccoli Raab Causes Disease in Subsequentalisalensis from broccoli raab causes disease in subsequentsyringae pv. maculicola causes bacterial spot on many

  2. Rheumatic Heart Disease and Beta-hemolytic Streptococci in Salvador, Brazil: A Study of Slum Health

    E-Print Network [OSTI]

    Tartof, Sara Yee

    2010-01-01

    rheumatic fever and rheumatic heart disease in Africa. S Afrthe chain that links the heart to the throat? Lancet Infectchildren with rheumatic heart disease. J Thorac Cardiovasc

  3. Is coronary heart disease rising in India? A systematic review based on ECG defined coronary heart disease 

    E-Print Network [OSTI]

    Ahmad, N; Bhopal, Raj

    2005-01-01

    The aim of this study was to investigate whether coronary heart disease (CHD) is rising in India and assess the quality of the evidence. Thirty one studies were reviewed. The sample sizes of the studies varied from ...

  4. New insights into the natural history of thrombo-embolic disease provided by imaging and disease quantification 

    E-Print Network [OSTI]

    Murchison, John Tallach

    2013-07-06

    Venous thromboembolism (VTE) is a common disease with a myriad of presentation. It is often difficult to diagnosis with symptoms which are shared with many other disorders. Because of the overlap in symptomatology with ...

  5. Profoundly different prion diseases in knock-in mice carrying single PrP codon substitutions associated with human diseases

    E-Print Network [OSTI]

    Jackson, Walker S.

    In man, mutations in different regions of the prion protein (PrP) are associated with infectious neurodegenerative diseases that have remarkably different clinical signs and neuropathological lesions. To explore the roots ...

  6. Airborne spread of foot-and-mouth disease - model intercomparison

    SciTech Connect (OSTI)

    Gloster, J; Jones, A; Redington, A; Burgin, L; Sorensen, J H; Turner, R; Dillon, M; Hullinger, P; Simpson, M; Astrup, P; Garner, G; Stewart, P; D'Amours, R; Sellers, R; Paton, D

    2008-09-04

    Foot-and-mouth disease is a highly infectious vesicular disease of cloven-hoofed animals caused by foot-and-mouth disease virus. It spreads by direct contact between animals, by animal products (milk, meat and semen), by mechanical transfer on people or fomites and by the airborne route - with the relative importance of each mechanism depending on the particular outbreak characteristics. Over the years a number of workers have developed or adapted atmospheric dispersion models to assess the risk of foot-and-mouth disease virus spread through the air. Six of these models were compared at a workshop hosted by the Institute for Animal Health/Met Office during 2008. A number of key issues emerged from the workshop and subsequent modelling work: (1) in general all of the models predicted similar directions for 'at risk' livestock with much of the remaining differences strongly related to differences in the meteorological data used; (2) determination of an accurate sequence of events is highly important, especially if the meteorological conditions vary substantially during the virus emission period; and (3) differences in assumptions made about virus release, environmental fate, and subsequent infection can substantially modify the size and location of the downwind risk area. Close relationships have now been established between participants, which in the event of an outbreak of disease could be readily activated to supply advice or modelling support.

  7. Familial Parkinson's Disease-associated L166P Mutation Disrupts DJ-1 Protein Folding and Function*

    E-Print Network [OSTI]

    Li, Lian

    Familial Parkinson's Disease-associated L166P Mutation Disrupts DJ-1 Protein Folding and Function by which loss-of-function mutations in DJ-1 lead to Par- kinson's disease. Parkinson's disease (PD)1 of this devastating disease. Recent evidence indi- cates that at least 10 distinct genetic loci, PARK1­PARK10

  8. Clues to How Alpha-Synuclein Damages Neurons in Parkinson's Disease

    E-Print Network [OSTI]

    Sulzer, David

    -synuclein; Parkinson's disease a-SYN AS A CAUSE OF PARKINSON'S DISEASE Multiple genetic mutations can cause ParkinsonClues to How Alpha-Synuclein Damages Neurons in Parkinson's Disease David Sulzer, PhD* Departments vesicles. The pathogenic effects of a-syn leading to Parkin- son's disease (PD) appear to result from

  9. South Carolina Pest Management Handbook for Field Crops -2015 TOBACCO DISEASE MANAGEMENT

    E-Print Network [OSTI]

    Stuart, Steven J.

    South Carolina Pest Management Handbook for Field Crops - 2015 293 TOBACCO DISEASE MANAGEMENT Bruce and potentially devastating diseases of tobacco can best be managed through a combination of control methods. It is urged that growers identify disease problems in their fields and follow disease management suggestions

  10. Estimating Seasonal Drivers in Childhood Infectious Diseases with Continuous Time Models 

    E-Print Network [OSTI]

    Abbott, George H.

    2010-07-14

    similar results for a relatively unstudied city in childhood infectious disease research, Bangkok, Thailand....

  11. Remote sensing, global warming, and vector-borne disease

    SciTech Connect (OSTI)

    Wood, B.; Beck, L.; Dister, S.; Lobitz, B.

    1997-12-31

    The relationship between climate change and the pattern of vector-borne disease can be viewed at a variety of spatial and temporal scales. At one extreme are changes such as global warming, which are continental in scale and occur over periods of years, decades, or longer. At the opposite extreme are changes associated with severe weather events, which can occur at local and regional scales over periods of days, weeks, or months. Key ecological factors affecting the distribution of vector-borne diseases include temperature, precipitation, and habitat availability, and their impact on vectors, pathogens, reservoirs, and hosts. Global warming can potentially alter these factors, thereby affecting the spatial and temporal patterns of disease.

  12. Using dimension reduction to improve outbreak predictability of multistrain diseases

    E-Print Network [OSTI]

    Leah B. Shaw; Lora Billings; Ira B. Schwartz

    2006-07-12

    Multistrain diseases have multiple distinct coexisting serotypes (strains). For some diseases, such as dengue fever, the serotypes interact by antibody-dependent enhancement (ADE), in which infection with a single serotype is asymptomatic, but contact with a second serotype leads to higher viral load and greater infectivity. We present and analyze a dynamic compartmental model for multiple serotypes exhibiting ADE. Using center manifold techniques, we show how the dynamics rapidly collapses to a lower dimensional system. Using the constructed reduced model, we can explain previously observed synchrony between certain classes of primary and secondary infectives (Schwartz et al., Phys. Rev. E 72: 066201, 2005). Additionally, we show numerically that the center manifold equations apply even to noisy systems. Both deterministic and stochastic versions of the model enable prediction of asymptomatic individuals that are difficult to track during an epidemic. We also show how this technique may be applicable to other multistrain disease models, such as those with cross-immunity.

  13. Investigation of saliva of patients with periodontal disease using NAA

    SciTech Connect (OSTI)

    Zamboni, C. B.; Metairon, S.; Medeiros, I. M. M. A.

    2013-05-06

    In this study the non-stimulated whole saliva of 26 healthy subjects (mean age 33.9 {+-} 11.0 years, range: 26 to 49 years) and 11 patients with periodontal disease (mean age 41.7 {+-} 11.5 years; range 29 to 55 years) was investigated using Neutron Activation Analysis (NAA) technique. The samples were obtained from donors at Sao Paulo city (Brazil). The analyses were performed in the nuclear reactor IEA-R1 (3.5-4.5MW, pool type) at IPEN/CNEN-SP (Brazil). Considerable changes in Ca and S saliva's level were identified in patients with periodontal disease suggesting they can be used as monitors of periodontal diseases.

  14. Complications of treatment of Hodgkin's disease in children

    SciTech Connect (OSTI)

    Donaldson, S.S.; Kaplan, H.S.

    1982-04-01

    An analysis of complications of therapy requires long-term and frequent followup. Reported here is a review of 179 consecutive children with Hodgkin's disease from Stanford University Medical Center who were seen, treated, and followed over a 20-year period. Complications of treatment are related to the extent of disease and the aggressiveness of therapy. Severe complications from radiotherapy are associated with high-dose, extended-field treatment in preadolescent children. Severe chemotherapy-associated complications include immunosuppression, sterility, and secondary oncogenesis. As cure rates are increasingly optimistic among children with Hodgkin's disease, successful treatment with minimal morbidity remains our greatest challenge. Therapy programs require continual refinement utilizing assessment of short- and long-term side effects of treatment.

  15. Compositions and Methods for the Treatment of Pierce's Disease

    DOE Patents [OSTI]

    Gupta, Goutam (Santa Fe, NM)

    2008-10-07

    Chimeric anti-microbial proteins, compositions, and methods for the therapeutic and prophylactic treatment of plant diseases caused by the bacterial pathogen Xylella fastidiosa are provided. The anti-microbial proteins of the invention generally comprise a surface recognition domain polypeptide, capable of binding to a bacterial membrane component, fused to a bacterial lysis domain polypeptide, capable of affecting lysis or rupture of the bacterial membrane, typically via a fused polypeptide linker. In particular, methods and compositions for the treatment or prevention of Pierce's disease of grapevines are provided. Methods for the generation of transgenic Vitus vinefera plants expressing xylem-secreted anti-microbial chimeras are also provided.

  16. Neurobiology of Disease Cortical Folding Abnormalities in Autism Revealed by

    E-Print Network [OSTI]

    Van Essen, David

    Neurobiology of Disease Cortical Folding Abnormalities in Autism Revealed by Surface-based morphometry across a range of autism spectrum disorders (7.5­18 years of age). We generated sulcal depth maps autism spectrum disorder subgroups: low-functioning autism, high-functioning autism, and Asperger

  17. Disease Risks Associated with Importation of Nonindigenous Marine Animals

    E-Print Network [OSTI]

    at the Nonindigenous Marine Species Plan ning Mt;eting of the National Research Council, Washington, D.C., 7 May 1991 directed to the third-disease and its implications in introductions. This is entirely logical, since infections that may cause stunting (Kalagayan et aI., 1991). Experimental infections with IHHNV have been

  18. Azasugar inhibitors as pharmacological chaperones for Krabbe disease

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Hill, Chris H.; Viuff, Agnete H.; Spratley, Samantha J.; Salamone, Stéphane; Christensen, Stig H.; Read, Randy J.; Moriarty, Nigel W.; Jensen, Henrik H.; Deane, Janet E.

    2015-03-23

    Krabbe disease is a devastating neurodegenerative disorder characterized by rapid demyelination of nerve fibers. This disease is caused by defects in the lysosomal enzyme ?-galactocerebrosidase (GALC), which hydrolyzes the terminal galactose from glycosphingolipids. These lipids are essential components of eukaryotic cell membranes: substrates of GALC include galactocerebroside, the primary lipid component of myelin, and psychosine, a cytotoxic metabolite. Mutations of GALC that cause misfolding of the protein may be responsive to pharmacological chaperone therapy (PCT), whereby small molecules are used to stabilize these mutant proteins, thus correcting trafficking defects and increasing residual catabolic activity in cells. Here we describe amore »new approach for the synthesis of galacto-configured azasugars and the characterization of their interaction with GALC using biophysical, biochemical and crystallographic methods. We identify that the global stabilization of GALC conferred by azasugar derivatives, measured by fluorescence-based thermal shift assays, is directly related to their binding affinity, measured by enzyme inhibition. X-ray crystal structures of these molecules bound in the GALC active site reveal which residues participate in stabilizing interactions, show how potency is achieved and illustrate the penalties of aza/iminosugar ring distortion. The structure–activity relationships described here identify the key physical properties required of pharmacological chaperones for Krabbe disease and highlight the potential of azasugars as stabilizing agents for future enzyme replacement therapies. This work lays the foundation for new drug-based treatments of Krabbe disease.« less

  19. Transmission mode and disease thresholds in host communities Janis Antonovics,

    E-Print Network [OSTI]

    Antonovics, Janis

    1 Transmission mode and disease thresholds in host communities Janis Antonovics, Department of Biology, University of Virginia, VA 22904, USA E-mail: ja8n@virginia.edu Running title Transmission mode transmission have close analogies with thresholds for species persistence when there is competition

  20. Polymorphism in sexual versus non-sexual disease transmission

    E-Print Network [OSTI]

    Antonovics, Janis

    Polymorphism in sexual versus non-sexual disease transmission PETER H. THRALL AND JANIS ANTONOVICS conditions under which a genetic variant with one (e.g. sexual) transmission mode can invade and successfully displace a genetic variant with a different (e.g. non-sexual) transmission mode. Invasion by an STD

  1. GUANYLATE CYCLASE-ACTIVATING PROTEINS AND RETINA DISEASE

    E-Print Network [OSTI]

    Palczewski, Krzysztof

    of the rod cell contains high levels of cGMP (1­10 M) maintaining a number of CNG channels in an open state. Within milliseconds after a light flash, cGMP-gated (CNG) cation channels close and photoreceptor cells hyperpolarize. Open CNG 71 E. Carafoli and M. Brini (eds.), Calcium Signalling and Disease, 71­91. © 2007

  2. Intrinsically Disordered Proteins: Regulation and Disease Regulation of IDPs

    E-Print Network [OSTI]

    Babu, M. Madan

    31st Jan 2011 Intrinsically Disordered Proteins: Regulation and Disease Regulation of IDPs M. Madan.....................................................................................................................................2 3.1. IDPs are tightly regulated from transcript synthesis to protein degradation ......................................................................................................................................8 #12;1 Abstract Intrinsically disordered proteins (IDPs) are often enriched in signaling

  3. September/October 2000 New Disease Booklet Web Marketing

    E-Print Network [OSTI]

    Ishida, Yuko

    the Restrictions Strawberry Pollination CSBA Convention Schedule Honey Quality CA Organic Farming New Disease is the APHIS Publication Distribution Center. Strawberry Pollination We don't often look at state or provincial, of Manitoba Agriculture, devised experiments to determine the effect of insect pollination on a strawberry

  4. Bayesian approach to transforming public gene expression repositories into disease

    E-Print Network [OSTI]

    Zhou, Xianghong Jasmine

    expression data and heterogeneous disease annota- tions, allows analyzing both sources of information concepts. This effort requires the effective integration of the two major information sources in the GEO of Southern California, Los Angeles, CA 90089; and c Institute of Genomics and Bioinformatics, National Chung

  5. PUBLICATION 600-080 Fish Health and Disease

    E-Print Network [OSTI]

    Liskiewicz, Maciej

    PUBLICATION 600-080 Fish Health and Disease Striped bass (Morone saxitilis) and hybrid striped bass these fish are commonly raised in high densities under intensive aquaculture situations (e.g., cages, ponds of the viral, bacterial, fungal, and parasitic pathogens, but the fish become increasingly susceptible

  6. Mathematical models and the fight against diseases in Africa

    E-Print Network [OSTI]

    Getz, Wayne M.

    Mathematical models and the fight against diseases in Africa Wayne M.Getz a* ,Eleanor Gouws b theories. While South Africa has many talented scientists trained in quantitative methods, relatively few infrastructural investment is needed to address the health crises in Africa. Prior to the advent of HIV

  7. Diseases of plantation forestry trees in eastern and southern Africa

    E-Print Network [OSTI]

    Diseases of plantation forestry trees in eastern and southern Africa J. Roux a*, G. Meke b , B a Introduction Plantations of non-native trees have been grown in Africa for more than 100 years.1,2 The most especially for construction timber and fuel, while in southern Africa this timber also sustains a thriving

  8. Virus Specificity in Disease Systems: Are Species Redundant?

    E-Print Network [OSTI]

    Flecker, Alex

    Chapter 17 m Virus Specificity in Disease Systems: Are Species Redundant? Alison G. Power about the effects of plant viruses despite their ubiquitous distribution in plants. Several recent studies have stressed the prevalence of viruses in natural plant populations (e.g., Power and Remold 1996

  9. 2006 International Centre for Diarrhoeal Disease Research, Bangladesh

    E-Print Network [OSTI]

    California at Berkeley, University of

    © 2006 International Centre for Diarrhoeal Disease Research, Bangladesh J HEALTH POPUL NUTR 2006, including Inner Mongolia, Thailand, Cambodia, and Bangladesh (2-4). In all these regions, the main source suggests the presence of arsenic in ground- water in India and Bangladesh throughout the region defined

  10. Random Disease on the Square Grid J ozsef Balogh

    E-Print Network [OSTI]

    Balogh, Jozsef

    a disease process. The initial configuration is called contagious or successful if the corresponding) squares in a contagious configuration. The solution of the initial exercise is the following: Fact. [Folklore] G(n) = n. Proof. If we paint the squares of a diagonal black, it will be a contagious

  11. Comparing Online Community Structure of Patients of Chronic Diseases

    E-Print Network [OSTI]

    Maddali, Hanuma Teja; Margolis, Peter

    2015-01-01

    In this paper we compare the social network structure of people talking about Crohn's disease, Cystic Fibrosis, and Type 1 diabetes on Facebook and Twitter. We find that the Crohn's community's contributors are most emotional on Facebook and Twitter and most negative on Twitter, while the T1D community's communication network structure is most cohesive.

  12. Prediction and Informative Risk Factor Selection of Bone Diseases

    E-Print Network [OSTI]

    Buffalo, State University of New York

    --Electronic health records (EHRs); risk factor analysis; integrated feature extraction; risk factor selection1 Prediction and Informative Risk Factor Selection of Bone Diseases Hui Li, Xiaoyi Li, Murali and the overwhelming amount of electronic health records (EHRs) shared by healthcare institutions and practitioners, we

  13. A Network-Based Approach to Understanding and Predicting Diseases

    E-Print Network [OSTI]

    Chawla, Nitesh V.

    and emergent behavior over time. Our analysis reveals important insights with implications for modeling increases in cost of health care for the United States. Contributions: The aforementioned issues model to assess disease risk for individuals based on medical history. We evaluate the ability of our

  14. Order, disorder, and protein aggregation

    E-Print Network [OSTI]

    Gurry, Thomas

    2015-01-01

    Protein aggregation underlies a number of human diseases. Most notably, it occurs widely in neurodegenerative diseases, including Alzheimer's and Parkinson's. At the molecular level, neurotoxicity is thought to originate ...

  15. Effects of Chronic Nicotine Exposure and Lack of High Affinity Nicotinic Receptors on Cortico-Hippocampal Areas in the Aging Mouse Brain 

    E-Print Network [OSTI]

    Huang, Pei-San

    2012-07-16

    performance. Epidemiology studies show that smoking is negatively correlated with the incidence of Parkinson's disease and Alzheimer's disease. Postmortem research and neuroimaging studies show that loss of nicotinic binding sites in the brain is the major...

  16. AT A GLANCE....INSECTS AND DISEASE PROBLEMS THAT SHOULD BE CONSIDERED THIS PEST/DISEASE/CULTURE

    E-Print Network [OSTI]

    Goodman, Robert M.

    /DISEASE/CULTURE JULY 8- JULY 15 HARVEST JULY 15- JULY 22 HARVEST SPOTTED WING DROSOPHILA Lannate, Imidan, Malathion effective against aphids and maggot when possible. Monitor with traps, and use materials that are also effective against aphids and maggot when possible. BLUEBERRY MAGGOT See list from previous newsletter

  17. Visualization and Functional Analysis of Genome-Wide Association Results

    E-Print Network [OSTI]

    Li, Jing

    genetic risks of several complex diseases including cancers, obesity, and type 2 diabetes using GWAS such as neurodegenerative diseases (e.g., Alzheimer's disease (AD) and Parkinson's disease), cardiovascular diseases patterns of genetic markers and the trait of interest within families, and establish linkage of disease

  18. Surgical Neurology International Editor: James I. Ausman, MD, PhD

    E-Print Network [OSTI]

    , Alzheimer's disease (AD), depression, anxiety syndrome, Parkinson's disease (PD), and prion diseases to conditions such as PD and prion diseases. Key Words: Autism, cholestasis, glyphosate, manganese, Parkinson://www.surgicalneurologyint.com Original Article Glyphosate, pathways to modern diseases III: Manganese, neurological diseases

  19. Unusual thoracic radiographic findings in children treated for Hodgkin's disease

    SciTech Connect (OSTI)

    Jochelson, M.S.; Tarbell, N.J.; Weinstein, H.J.

    1986-06-01

    Mantle irradiation is often part of the treatment for Hodgkin's disease. Localized pneumonitis and fibrosis are well-known sequelae of this treatment. We report nine patients with unusual thoracic radiographic findings following treatment for Hodgkin's disease. All nine had mediastinal widening. Seven of these patients received combined modality therapy in which prednisone was given with their MOPP. In these seven patients, an increase in mediastinal width developed at the same time as the radiographic changes of radiation pneumonitis. Two patients developed bilateral infiltrates extending beyond the field of radiation to the lung periphery. In one of these patients, a spontaneous pneumomediastinum developed. One patient underwent mediastinal biopsy that revealed inflammatory changes similar to those seen in radiation pneumonitis. All patients either responded to steroids or had spontaneous regression of radiographic abnormalities supporting the presumed diagnosis of treatment related changes. Recognition of these unusual sequelae of mantle irradiation will aid in differentiating them from infection or tumor and lead to prompt, appropriate treatment.

  20. Travel and migration associated infectious diseases morbidity in Europe, 2008

    E-Print Network [OSTI]

    Field, Vanessa; Gautret, Philippe; Schlagenhauf, Patricia; Burchard, Gerd-Dieter; Caumes, Eric; Jensenius, Mogens; Castelli, Francesco; Gkrania-Klotsas, Effrossyni; Weld, Leisa; Lopez-Velez, Rogelio; de Vries, Peter; von Sonnenburg, Frank; Loutan, Louis; Parola, Philippe; Network, the EuroTravNet

    2010-11-17

    to adjust for the large number of statistical tests performed. Ethics approval The GeoSentinel International data-collection protocol used by EuroTravNet was reviewed by the institutional review board officer at the National Center for Infec- tious Diseases... on a return visit to his country of birth Algeria; three cases of toxo- plasmosis, 20 cases of acute Epstein Barr Virus infection, and one case of histoplasmosis. Bacterial infections accounted for most dermatological diagnoses followed by arthropod...

  1. Storage and Diseases of the Sweet Potato in Texas. 

    E-Print Network [OSTI]

    Youngblood, B. (Bonney)

    1919-01-01

    STATION AGRICULTURAL AND MECHANICAL COLLEGE OF TEXAS W. B. BIZZELL, President BULLETIN TuO. 250 OCTOBER, 1919 EXPERIMENT STATION AND EXTENSION SERVICE COOPERATING STORAGE AND DISEASES OF THE SWEET POTATO IN TEXAS B. YOUNGBLOOD, DIRECTOR College... cooperation with the United States Department of Agriculture. FOREWORD. Sweet potato storage is a comparatively new industry in Texas. Dur- ing the past few years, hoaeyer, a great deal of interest has been mani- fested in improved methods of storage...

  2. A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

    E-Print Network [OSTI]

    Pagliarini, David J.

    James G. Evans,8 David R. Thorburn,5,6 Steven A. Carr,3,* and Vamsi K. Mootha1,2,3,* 1Center for HumanA Mitochondrial Protein Compendium Elucidates Complex I Disease Biology David J. Pagliarini,1 A. Walford,1,2 Canny Sugiana,5 Avihu Boneh,5,6 William K. Chen,1,2 David E. Hill,7 Marc Vidal,7

  3. Pathogenesis of human papillomavirus-associated mucosal disease

    E-Print Network [OSTI]

    Groves, Ian J.; Coleman, Nicholas

    2014-12-08

    =UTF-8 For Peer Review Pathogenesis of human papillomavirus-associated mucosal disease. Journal: The Journal of Pathology Manuscript ID: Draft Wiley - Manuscript type: Invited Review Date Submitted by the Author: n/a Complete... advantage. Selection of integrated HRHPV occurs relatively early in cervical carcinogenesis and determinants of selection have been difficult to investigate adequately using clinical samples [36]. However, the W12 model of HPV16-associated cervical...

  4. Using Genomics to Study Human Biology and Disease

    SciTech Connect (OSTI)

    Myers, Ricard M.

    2005-04-06

    The Human Genome Project culminated in April 2003 with the finished DNA sequence of all of the human chromosomes. This book of information, particularly in conjunction with the genome sequences of many other organisms, has already begun to revolutionize the way that biomedical scientists study our species. The identification of essentially all of our genes has provided a template upon which researchers can discover basic processes that govern cells, organs, and the whole organism, and to understand the fundamental causes of the diseases that occur when something goes wrong with a gene or a set of genes. The Genome Project has already made it possible to identify the genes that are defective in more than 1,000 rare inherited diseases, and these discoveries have helped to understand the mechanisms of the more common forms of these disorders. This understanding of primary defects in diseases - which is translated as mutations in genes that encode proteins that serve specific functions - is transforming the way that biotechnology and pharmaceutical companies identify drug targets, and a few notable cases have already had a striking impact on specific diseases. In addition, it has become clear that the differential response to drugs in human populations is heavily influenced by genes, and a whole field called pharmacogenetics has begun to identify these genetic factors. Such knowledge will allow physicians to prescribe drugs targeted to each individual, with the potential to increase efficacy and decrease side-effects. Determining the DNA sequence of the human genome and identifying the genes has been an exciting endeavor, but we are only just beginning to understand the treasures present in all of our DNA. My presentation will briefly describe the road we took to get the sequence, as well as the tools that we are developing to unlock its secrets.

  5. Selection of a multiple disease resistant runner-type peanut 

    E-Print Network [OSTI]

    Baring, Michael Robert

    2007-09-17

    SELECTION OF A MULTIPLE DISEASE RESISTANT RUNNER-TYPE PEANUT A Thesis by MICHAEL ROBERT BARING Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE... of the requirements for the degree of MASTER OF SCIENCE Approved by: Chair of Committee, William Rooney Committee Members, Charles Simpson James Starr Robert Lemon Head of Department, C.W. Smith May 2006 Major Subject: Plant...

  6. Disease-induced resource constraints can trigger explosive epidemics

    E-Print Network [OSTI]

    Böttcher, Lucas; Araújo, Nuno A M; Herrmann, Hans J; Helbing, Dirk

    2015-01-01

    Advances in mathematical epidemiology have led to a better understanding of the risks posed by epidemic spreading and informed strategies to contain disease spread. However, a challenge that has been overlooked is that, as a disease becomes more prevalent, it can limit the availability of the capital needed to effectively treat those who have fallen ill. Here we use a simple mathematical model to gain insight into the dynamics of an epidemic when the recovery of sick individuals depends on the availability of healing resources that are generated by the healthy population. We find that epidemics spiral out of control into "explosive" spread if the cost of recovery is above a critical cost. This can occur even when the disease would die out without the resource constraint. The onset of explosive epidemics is very sudden, exhibiting a discontinuous transition under very general assumptions. We find analytical expressions for the critical cost and the size of the explosive jump in infection levels in terms of the...

  7. Gamma-Glutamyltransferase: A Predictive Biomarker of Cellular Antioxidant Inadequacy and Disease Risk

    E-Print Network [OSTI]

    Koenig, Gerald

    2015-01-01

    Gamma-glutamyltransferase (GGT) is a well-established serum marker for alcohol-related liver disease. However, GGT’s predictive utility applies well beyond liver disease: elevated GGT is linked to increased risk to a ...

  8. Approaches to in vitro tissue regeneration with application for human disease modeling and drug development

    E-Print Network [OSTI]

    Young, Carissa L.

    Reliable in vitro human disease models that capture the complexity of in vivo tissue behaviors are crucial to gain mechanistic insights into human disease and enable the development of treatments that are effective across ...

  9. Correlation of Klebsiella pneumoniae Comparative Genetic Analyses with Virulence Profiles in a Murine Respiratory Disease Model

    E-Print Network [OSTI]

    Fodah, Ramy A.

    Klebsiella pneumoniae is a bacterial pathogen of worldwide importance and a significant contributor to multiple disease presentations associated with both nosocomial and community acquired disease. ATCC 43816 is a well-studied ...

  10. Precision medicine in chronic disease management: The multiple sclerosis BioScreen

    E-Print Network [OSTI]

    2014-01-01

    Disease Management: The Multiple Sclerosis BioScreen Pierre-unpredictable disease like multiple sclerosis? Eur J NeurolHL. The challenge of multiple sclerosis: how do we cure a

  11. Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk

    E-Print Network [OSTI]

    Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk (Cervus). Subsequently, the disease was diagnosed in black-tailed deer, Rocky Mountain elk (Williams & Young, 1982, 1992

  12. Curing CNS autoimmune disease with myelin-reactive Foxp3+ Treg. 

    E-Print Network [OSTI]

    Stephens LA; Malpass KH; Anderton SM

    2009-01-01

    The potential use of CD4(+)Foxp3(+) Treg as a cellular therapy for autoimmune disease is of great interest. For clinical translation, the key objective is to reverse established disease. Here we demonstrate that myelin ...

  13. Inflammation and haemostasis in the development and progression of peripheral atherosclerotic disease 

    E-Print Network [OSTI]

    Tzoulaki, Ioanna

    2007-01-01

    Peripheral arterial disease (PAD) defines atherosclerotic disease of the arteries to the legs. PAD begins early in life and remains asymptomatic over long periods. The ankle brachial index (ABI) is an important diagnostic ...

  14. Morphological, cellular and proteomic features of canine myxomatous mitral valve disease 

    E-Print Network [OSTI]

    Han, Richard I-Ming

    2009-01-01

    Myxomatous mitral valve degeneration (MMVD) is the single most common cardiac disease of the dog, and is analogous to Mitral Valve Prolapse in humans. Very little is known about the aetiopathogenesis of this disease or ...

  15. Economic Consequences Associated with Johne’s Disease in Cow-Calf Operations 

    E-Print Network [OSTI]

    Bhattarai, Bikash

    2013-08-05

    Johne’s disease (JD) in cattle is a disease of economic importance caused by Mycobacterium avium subspecies paratuberculosis (MAP). Studies were conducted to estimate the losses due to lower weaning weight of beef calves ...

  16. HUMAN DISEASE FROM RADON EXPOSURES: THE IMPACT OF ENERGY CONSERVATION IN BUILDINGS

    E-Print Network [OSTI]

    Budnitz, R.J.

    2011-01-01

    Snihs, "The Significance of Radon and Its Progeny as NaturalDivision Human Disease from Radon Exposures: The I P ImpactVent 78-5 HUMAN DISEASE FROM RADON EXPOSURES: THE IMPACT OF

  17. v-abl causes hematopoietic disease distinct from that caused by bcr-abl.

    E-Print Network [OSTI]

    Scott, M L; Van Etten, R A; Daley, G Q; Baltimore, D

    1991-01-01

    Medical Sciences v-abl causes hematopoietic disease distinctcells. bcr-abl also causes a CML-like syndrome in mice whosevirus-containing sys- tem, causes disease similar to, but

  18. Structural Findings in the Basal Ganglia in Genetically Determined and Idiopathic Parkinson's Disease

    E-Print Network [OSTI]

    Gaser, Christian

    Structural Findings in the Basal Ganglia in Genetically Determined and Idiopathic Parkinson likely have an increased risk to develop Parkinson's disease (PD). We hypothesized BG morphological Key words: basal ganglia; magnetic resonance imaging; Parkinson's disease; Parkin mutation carriers

  19. Immunization with a Borrelia burgdorferi BB0172-Derived Peptide Protects Mice against Lyme Disease 

    E-Print Network [OSTI]

    Small, Christina M.; Ajithdoss, Dharani K.; Hoffmann, Aline Rodrigues; Mwangi, Waithaka; Esteve-Gassent, Maria D.

    2014-02-05

    Lyme disease is the most prevalent arthropod borne disease in the US and it is caused by the bacterial spirochete Borrelia burgdorferi (Bb), which is acquired through the bite of an infected Ixodes tick. Vaccine development efforts focused...

  20. The development of new tools for field and laboratory diagnosis of Pierces Disease 

    E-Print Network [OSTI]

    Bryan, Kelly Asbill

    2009-05-15

    Pierce’s Disease (PD), caused by Xylella fastidiosa, is a devastating bacterial disease of grapevines. One of the few control options is roguing. Roguing depends on precise diagnosis of PD in vines. These experiments were conducted to improve...

  1. High-Oleic Ground Beef and Risk Factors for Cardiovascular Disease in Men and Postmenopausal Women 

    E-Print Network [OSTI]

    Ghahramany, Ghazal

    2012-07-16

    About half of all deaths in developed countries are caused by cardiovascular disease. It is well known that cardiovascular disease (CVD) risk can be influenced by diet, but optimal dietary content of fatty acids continues ...

  2. Di#erential equation models for Aujeszky's Disease Virus (ADV) in Irish pig herds

    E-Print Network [OSTI]

    , Dublin City University, Dublin 9, Ireland Abstract Aujeszky's Disease virus, (ADV) is a contagious viral Aladar Aujeszky, when he distinguished psuedorabies from rabies [23]. Aujeszky's Disease is a contagious

  3. Micro-Simulations of Infectious Disease using Official Register Data The Case of Smallpox

    E-Print Network [OSTI]

    Boman, Magnus

    , for example. #12;Introduction Should an infection of a contagious disease occur, the potential threat must be seen as an example of a predominantly airborne, fairly contagious vaccine-preventable disease where

  4. Pharmacological Chaperone Design for Reducing Risk Factor of Parkinson’s Disease from Traditional Chinese Medicine

    E-Print Network [OSTI]

    Huang, Hung-Jin

    Dysfunction of ?-glucocerebrosidase (GCase) has no hydrolytic activity in patients of Gaucher's disease and increasing the risk factor for Parkinson’s disease occurrence. Pharmacological chaperone design has been used to ...

  5. CNS Infiltration of Peripheral Immune Cells: D-Day for Neurodegenerative Disease?

    E-Print Network [OSTI]

    Rezai-Zadeh, Kavon; Gate, David; Town, Terrence

    2009-01-01

    encephalitis . multiple sclerosis . experimental autoimmunedisease (AD), multiple sclerosis (MS), and Parkinson'sdemyelinating disease multiple sclerosis) and may also be

  6. Association Analysis of the Extended MHC Region in Celiac Disease Implicates Multiple Independent Susceptibility Loci

    E-Print Network [OSTI]

    2012-01-01

    Symposium on Coeliac Disease. Tampere, Finland: Institute ofTechnology, University of Tampere. pp 265–274. 25. Hall RP,

  7. "Red Sore Disease"in Game Fish1 Peggy Reed and Ruth Francis-Floyd2

    E-Print Network [OSTI]

    Watson, Craig A.

    VM85 "Red Sore Disease"in Game Fish1 Peggy Reed and Ruth Francis-Floyd2 1. This document is VM85 fish is generically referred to as "red sore disease." This problem usually occurs in the spring on their fish. Typically, "red sore disease" is caused by two organisms, Aeromonas hydrophila , a bacterium

  8. The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit

    E-Print Network [OSTI]

    Guo, Ming

    of Parkinson's disease. pink1 acts upstream of parkin in a common genetic pathway to regulate mitochondrialThe Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion represent a novel therapeutic strategy for Parkinson's disease. mitofusin drp1 opa1 parkin-pink1 Parkinson

  9. 8 THE AMERICAN SOCIETY FOR CELL BIOLOGY PRESS BOOK 2004 arkinson's disease (PD) was named

    E-Print Network [OSTI]

    Feng, Jian

    as a progressive neurodegenerative disease. Parkinson's is caused by the selective death of neurons that produce-radical-damaged tubulin. In this fight, mutated parkin apparently arrives unarmed. Parkinson's Disease: Shootout8 THE AMERICAN SOCIETY FOR CELL BIOLOGY PRESS BOOK 2004 P arkinson's disease (PD) was named

  10. Neurodegeneration and Neuroprotection in Parkinson Disease Stanley Fahn and David Sulzer

    E-Print Network [OSTI]

    Sulzer, David

    Neurodegeneration and Neuroprotection in Parkinson Disease Stanley Fahn and David Sulzer Department Parkinson disease (PD) result primarily from the loss of the neuromelanin (NM)-containing dopamine (DA, with at least one of them being tremor-at-rest or brady- kinesia. Parkinson disease (PD) is the major cause

  11. Parkinson's disease (PD) is characterized by the rela-tively selective degeneration of dopaminergic neurons in

    E-Print Network [OSTI]

    Feng, Jian

    Parkinson's disease (PD) is characterized by the rela- tively selective degeneration into a stiff, hollow tube. Each Microtubule: A Common Target for Parkin and Parkinson's Disease Toxins JIAN performed on twins (Tanner and others 1999), reveal strong environmental connections to the disease

  12. Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by the

    E-Print Network [OSTI]

    Shorter, James

    Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by the loss motor and cognitive problems. Although the disease was first described in 1817 (Parkinson, 2002), few treatments exist today. These treatments do not target the cause of the disease and instead aim to increase

  13. Neurobiology of Disease Functional Analysis of VPS41-Mediated Neuroprotection in

    E-Print Network [OSTI]

    Caldwell, Guy

    elegans and Mammalian Models of Parkinson's Disease Adam J. Harrington,1 Talene A. Yacoubian,2 Sunny R Disruptionofthelysosomalsystemhasemergedasakeycellularpathwayintheneurotoxicityof -synuclein( -syn)andtheprogression of Parkinson's disease (PD). A large-scale RNA interference for the treatment of synucleinopathies like PD. Introduction Parkinson's disease (PD) is the second most common

  14. Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3

    E-Print Network [OSTI]

    Li, Lian

    Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase autosomal recessive forms of Parkinson disease (PD), but how these mutations trigger neurodegeneration pathway in the pathogenesis of PD. INTRODUCTION Parkinson disease (PD) is the most common neurodegenera

  15. Combined Analysis of Genome-wide Association Studies for Crohn Disease and Psoriasis

    E-Print Network [OSTI]

    Abecasis, Goncalo

    ARTICLE Combined Analysis of Genome-wide Association Studies for Crohn Disease and Psoriasis1,24,* Psoriasis (PS) and Crohn disease (CD) have been shown to be epidemiologically, pathologically and enlarge the map of shared genetic risk loci. Introduction Psoriasis (PS [MIM 177900]) and Crohn disease

  16. Cost-Sensitive Risk Stratification in the Diagnosis of Heart Disease

    E-Print Network [OSTI]

    Carbonell, Jaime

    Cost-Sensitive Risk Stratification in the Diagnosis of Heart Disease Selen Uguroglu and Jaime Pittsburgh, PA 15212 Abstract We investigate machine learning methods for diagnos- tic screening of heart disease. Coronary heart disease is the leading cause of death in the US, causing more deaths than all

  17. Arsenic exposure from drinking water and mortality from cardiovascular disease in Bangladesh: prospective cohort

    E-Print Network [OSTI]

    van Geen, Alexander

    13 million residents in the United States.1 Although the International Agency for Research on Cancer Death from cardiovascular disease. Results 198 people died from diseases of circulatory system, accounting for 43% of total mortality in the population. The mortality rate for cardiovascular disease

  18. The Diet-Heart Hypothesis: a critical appraisal of the relationship between diet and coronary artery disease

    E-Print Network [OSTI]

    Jurewitz, Daniel L

    2007-01-01

    for Prevention of Coronary Heart Disease. JAMA. 2002;288:M. Fish consumption and coronary heart disease mortality: aacid and risk of ischemic heart disease among women. Am J

  19. Detection of bone disease in dogs by radioisotope scanning 

    E-Print Network [OSTI]

    Morris, Earl Louis

    1971-01-01

    in dogs for the diagnosis and progression of bone disease was studied. Twc isotopes of strontium, Sr and 85 87m Sr, were studied. The Sr was purchased 85 commercially and the Sr was produced at the 87m Texas A8cM University Nuclear Science Center... by the irradiation oi' Sr(N05)2. Criteria for bone scanning in dogs using Sr 85 and Sr were determined. Pour normal young dogs 87m were injected with Sr and four with Sr. Doses 85 87m of 100 p&i of Sr and 1 mCi of Sr were found . to 85 87m produoe satisfactory...

  20. Development of Biomarkers for Chronic Beryllium Disease in Mice

    SciTech Connect (OSTI)

    Gordon, Terry

    2013-01-25

    Beryllium is a strategic metal, indispensable for national defense programs in aerospace, telecommunications, electronics, and weaponry. Exposure to beryllium is an extensively documented occupational hazard that causes irreversible, debilitating granulomatous lung disease in as much as 3 - 5% of exposed workers. Mechanistic research on beryllium exposure-disease relationships has been severely limited by a general lack of a sufficient CBD animal model. We have now developed and tested an animal model which can be used for dissecting dose-response relationships and pathogenic mechanisms and for testing new diagnostic and treatment paradigms. We have created 3 strains of transgenic mice in which the human antigen-presenting moiety, HLA-DP, was inserted into the mouse genome. Each mouse strain contains HLA-DPB1 alleles that confer different magnitude of risk for chronic beryllium disease (CBD): HLA-DPB1*0401 (odds ratio = 0.2), HLA-DPB1*0201 (odds ratio = 15), HLA-DPB1*1701 (odds ratio = 240). Our preliminary work has demonstrated that the *1701 allele, as predicted by human studies, results in the greatest degree of sensitization in a mouse ear swelling test. We have also completed dose-response experiments examining beryllium-induced lung granulomas and identified susceptible and resistant inbred strains of mice (without the human transgenes) as well as quantitative trait loci that may contain gene(s) that modify the immune response to beryllium. In this grant application, we propose to use the transgenic and Â?normal inbred strains of mice to identify biomarkers for the progression of beryllium sensitization and CBD. To achieve this goal, we propose to compare the sensitivity and accuracy of the lymphocyte proliferation test (blood and bronchoalveolar lavage fluid) with the ELISPOT test in the three HLA-DP transgenic mice strains throughout a 6 month treatment with beryllium particles. Because of the availability of high-throughput proteomics, we will also identify changes in potential protein biomarkers in beryllium-treated mice. We will correlate these findings with the ability of the transgenic mice to develop a beryllium-specific adaptive immune response in blood and bronchoalveolar lavage (BAL) fluid. We will also determine whether beryllium-responsive CD4+ T cells in blood and BAL correlate with the onset of granuloma formation. Thus, we will provide the scientific community with biomarkers of sensitization and disease progression for CBD. These biomarkers will serve as critical tools for development of improved industrial hygiene and therapeutic interventions.

  1. Programming of cardiovascular disease across the life-course

    E-Print Network [OSTI]

    Blackmore, Heather L.; Ozanne, Susan E.

    2014-12-12

    ]. This increase in lifespan brings about a rise in age-associated conditions such as type 2 diabetes, cancer and cardiovascular disease (CVD). As CVD has a long pre-clinical phase resulting in diagnosis in old age, the identification of biomarkers that precede... F, Carter F, Walsh SW, Kenny DA, Smith GW, Ireland JL, et al. Maternal undernutrition in cows impairs ovarian and cardiovascular systems in their offspring. Biol Reprod. 2013;88:92. [33] Gilbert JS, Lang AL, Grant AR, Nijland MJ. Maternal nutrient...

  2. The Emergence of ActualThe Emergence of Actual Human Disease as a Model forHuman Disease as a Model for

    E-Print Network [OSTI]

    Boguski, Mark S.

    + Chromosomome +e + ""icsics"" == GenomicsGenomics 1990 Human Genome Project launched1990 Human Genome Project launched 1998 Human Genome Project1998 Human Genome Project acceleratedaccelerated 20002000 ""DraftThe Emergence of ActualThe Emergence of Actual Human Disease as a Model forHuman Disease as a Model

  3. Osteogenic Sarcoma of the Maxilla: Neutron Therapy for Unresectable Disease

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Smoron, Geoffrey L.; Lennox, Arlene J.; Mcgee, James L.

    1999-01-01

    Purpose. To present a case study involving the use of fast neutron therapy to treat an extensive unresectable osteogenic sarcoma arising from the left maxilla. Patient. A 14-year-old male presented with a massive tumor producing severe distortion of his facial structures. He had already received six courses of chemotherapy, which had reduced his pain, but had not measurably reduced the tumor. Methods. The patient was treated with 66 MeV fast neutrons to a dose of 20.4 Gy in 13 fractions over 35 days. Results. CT assessments indicate gradually increasing calcification and noticeable reductionmore »of soft-tissue disease in the frontal sinus, orbit and maxillary antrum.There has been some recontouring of the facial structures.The boy conducts an active life, has no pain, and feels well. He was 17 years old at the last follow-up. Discussion. Fast neutrons have a greater biological effectiveness than conventional photon beams. Their use has been associated with improved chance for local control of unresectable disease.This case illustrates their effectiveness in controlling an unusual and aggressive osteogenic sarcoma of the facial bone and sinuses. « less

  4. Mechanistic Investigation of the Inhibition of A?42 Assembly and Neurotoxicity by A?42 C-terminal Fragments

    E-Print Network [OSTI]

    Benedek, George B.

    Oligomeric forms of amyloid ?-protein (A?) are key neurotoxins in Alzheimer’s disease (AD). Previously, we found that C-terminal fragments (CTFs) of A?42 interfered with assembly of full-length A?42 and inhibited A?42-induced ...

  5. Clifton folio Arizona 

    E-Print Network [OSTI]

    Lindgren, Waldemar, 1860-1939.

    1905-01-01

    years of the Alzheimer?s disease amyloid hypothesis: A genetic perspective. Cell 120:545-555 Thinakaran G, Koo EH (2008) Amyloid precursor protein trafficking, processing, and function. Biol Chem 283: 29615-29619. Turr?-Garriga O, L?pez-Pousa S...

  6. http://dx.doi.org/10.14336/AD *Correspondence should be addressed to: Gustavo C. Ferreira.Universidade do Extremo Sul Catarinense, Avenida

    E-Print Network [OSTI]

    Wenk, Gary

    and Parkinson's disease. These findings are also reported in inherited diseases such as phenylketonuria involved. Examples include Alzheimer's disease (AD), Parkinson's disease (PD), and others [1]. In most in these diseases, elicited by either genetic alterations (mitochondrial or nuclear DNA) or exogenous toxins

  7. Cyclophilin D Deficiency Rescues Axonal Mitochondrial Transport in Alzheimer’s Neurons

    E-Print Network [OSTI]

    Guo, Lan; Du, Heng; Yan, Shiqiang; Wu, Xiaoping; Mckhann, Guy M.; Chen, John Xi; Yan, Shirley ShiDu

    2013-01-31

    Normal axonal mitochondrial transport and function is essential for the maintenance of synaptic function. Abnormal mitochondrial motility and mitochondrial dysfunction within axons are critical for amyloid ? (A?)-induced synaptic stress and the loss...

  8. Bead-based microfluidic immunoassay for diagnosis of Johne's disease

    SciTech Connect (OSTI)

    Wadhwa, Ashutosh [University of Tennessee, Center for Wildlife Health, Department of Forestry; Foote, Robert [ORNL; Shaw, Robert W [ORNL; Eda, Shigetoshi [ORNL

    2012-01-01

    Microfluidics technology offers a platform for development of point-of-care diagnostic devices for various infectious diseases. In this study, we examined whether serodiagnosis of Johne s disease (JD) can be conducted in a bead-based microfluidic assay system. Magnetic micro-beads were coated with antigens of the causative agent of JD, Mycobacterium avium subsp. paratuberculosis. The antigen-coated beads were incubated with serum samples of JD-positive or negative serum samples and then with a fluorescently-labeled secondary antibody (SAB). To confirm binding of serum antibodies to the antigen, the beads were subjected to flow cytometric analysis. Different conditions (dilutions of serum and SAB, types of SAB, and types of magnetic beads) were optimized for a great degree of differentiation between the JD-negative and JD-positive samples. Using the optimized conditions, we tested a well-classified set of 155 serum samples from JD negative and JD-positive cattle by using the bead-based flow cytometric assay. Of 105 JD-positive samples, 63 samples (60%) showed higher antibody binding levels than a cut-off value determined by using antibody binding levels of JD-negative samples. In contrast, only 43-49 JD-positive samples showed higher antibody binding levels than the cut-off value when the samples were tested by commercially-available immunoassays. Microfluidic assays were performed by magnetically immobilizing a number of beads within a microchannel of a glass microchip and detecting antibody on the collected beads by laser-induced fluorescence. Antigen-coated magnetic beads treated with bovine serum sample and fluorescently-labeled SAB were loaded into a microchannel to measure the fluorescence (reflecting level of antibody binding) on the beads in the microfluidic system. When the results of five bovine serum samples obtained with the system were compared to those obtained with the flow cytometer, a high level of correlation (linear regression, r2 = 0.994) was observed. In a further experiment, we magnetically immobilized antigen-coated beads in a microchannel, reacted the beads with serum and SAB in the channel, and detected antibody binding to the beads in the microfluidic system. A strong antibody binding in JD-positive serum was detected, whereas there was only negligible binding in negative control experiments. Our data suggest that the bead-based microfluidic system may form a basis for development of an on-site serodiagnosis of JD. Key Words: Mycobacterium avium ssp. paratuberculosis, Johne s disease, microfluidics, lab-on-a-chip.

  9. ULTRASTRUCTURAL FEATURES OF CHROMATIN ~, BODIES ADA L. OLINS, MARILYN B. SENIOR, and DONALD E. OLINS. From the University of Tennessee-

    E-Print Network [OSTI]

    Olins, Ada L.

    prepared as usual (16, 18) except that the grids were stained and dried in 5 mM aqueous uranyl acetateH 7.0) (Eastman Kodak Co., Rochester, N.Y.), dried, and stained and dried in 5 mM aqueous uranyl

  10. UBC Social Ecological Economic Development Studies (SEEDS) Student Report Ada Cheung, Esther Lu, Fiona Wu, Liyan Zeng, Myeong Ju Jeon

    E-Print Network [OSTI]

    between subjects design. The data include results from compost or food, plastic or metal, paper, and waste, Fiona Wu, Liyan Zeng, Myeong Ju Jeon Changes in Waste-Sorting Behaviour with the Presence of Mirrors matter of a project/report". #12;Running Head: CHANGES IN WASTE-SORTING BEHAVIOUR 1 Changes in Waste

  11. Letters in Biomathematics An International Journal

    E-Print Network [OSTI]

    Rathinam, Muruhan

    Association (ADA), this set of diseases affects the lives of7 approximately 8.3% of the United States insulin. They exhibit electrical bursting behavior during insulin production that correlates with the rate. Simulations run with these mutations reveal the existence of a bursting death threshold, described

  12. Classification of interstitial lung disease patterns with topological texture features

    E-Print Network [OSTI]

    Huber, Markus B; Leinsinger, Gerda; Ray, Lawrence A; Wismüller, Axel; 10.1117/12.844318

    2010-01-01

    Topological texture features were compared in their ability to classify morphological patterns known as 'honeycombing' that are considered indicative for the presence of fibrotic interstitial lung diseases in high-resolution computed tomography (HRCT) images. For 14 patients with known occurrence of honey-combing, a stack of 70 axial, lung kernel reconstructed images were acquired from HRCT chest exams. A set of 241 regions of interest of both healthy and pathological (89) lung tissue were identified by an experienced radiologist. Texture features were extracted using six properties calculated from gray-level co-occurrence matrices (GLCM), Minkowski Dimensions (MDs), and three Minkowski Functionals (MFs, e.g. MF.euler). A k-nearest-neighbor (k-NN) classifier and a Multilayer Radial Basis Functions Network (RBFN) were optimized in a 10-fold cross-validation for each texture vector, and the classification accuracy was calculated on independent test sets as a quantitative measure of automated tissue characteriza...

  13. Ulcerative colitis and steroid-responsive, diffuse interstitial lung disease

    SciTech Connect (OSTI)

    Balestra, D.J.; Balestra, S.T.; Wasson, J.H.

    1988-07-01

    The authors describe a patient with ulcerative colitis and extracolonic manifestations in whom diffuse interstitial pulmonary disease developed that was responsive to glucocorticoid therapy one year after total proctocolectomy. The patient presented in December 1983 with a subacute course marked by cough and progressive exertional dyspnea, abnormal chest examination results, and a chest roentgenogram that revealed diffuse interstitital and alveolar infiltrates. A transbronchial biopsy specimen revealed a polymorphic interstitial infiltrate, mild interstitial fibrosis without apparent intraluminal fibrosis, and no vasculitis, granulomas, or significant eosinophilic infiltration. Within one week of the initiation of daily high-dose steroid therapy, the patient's symptoms dramatically improved; chest roentgenogram and forced vital capacity (60%) improved at a slower rate. All three measures deteriorated when alternate-day prednisone therapy was started but once again improved until the patient was totally asymptomatic, chest roentgenograms were normal, and forced vital capacity was 80% of the predicted value 2 1/2 years later.

  14. Why my disease is important: metrics of disease occurrence used in the introductory sections of papers in three leading general medical journals in 1993 and 2003

    E-Print Network [OSTI]

    Gouda, Hebe N.; Powles, John W.

    2011-05-23

    stream_source_info 1478-7954-9-14.pdf.txt stream_content_type text/plain stream_size 20996 Content-Encoding UTF-8 stream_name 1478-7954-9-14.pdf.txt Content-Type text/plain; charset=UTF-8 RESEARCH Open Access Why my disease... is important: metrics of disease occurrence used in the introductory sections of papers in three leading general medical journals in 1993 and 2003 Hebe N Gouda* and John W Powles Abstract Background: We assessed the metrics used in claims about disease...

  15. Development and application of mass spectrometry-based metabolomics methods for disease biomarker identification

    E-Print Network [OSTI]

    Tong, Lily Victoria

    2008-01-01

    Human societies face diverse health challenges including a rapidly aging population, rising incidence of metabolic disease, and increasing antibiotic resistance. These problems involve complex interactions between genes ...

  16. Relation of aortic valve calcium to chronic kidney disease (from the Chronic Renal Insufficiency Cohort Study)

    E-Print Network [OSTI]

    2015-01-01

    with calcific aortic valve disease. Cardiovascular HealthA, et al. Cardiac valve calcification in haemodialysisCurtis JR. Aortic and mitral valve calcification in patients

  17. Relation of Aortic Valve Calcium to Chronic Kidney Disease (from the Chronic Renal Insufficiency Cohort Study)

    E-Print Network [OSTI]

    2015-01-01

    with calcific aortic valve disease. Cardiovascular HealthA, et al. Cardiac valve calcification in haemodialysisCurtis JR. Aortic and mitral valve calcification in patients

  18. Integrated rotation systems for soilborne disease, weed and fertility management in strawberry/vegetable production

    E-Print Network [OSTI]

    2014-01-01

    dahliae infection rate of strawberry plants at the organicsoilborne diseases in strawberry using vegetable rotations.Fertility Management in Strawberry/Vegetable Production M.

  19. Possible common e,ological agent for strawberry disease and red mark syndrome in

    E-Print Network [OSTI]

    Kane, Andrew S.

    1 Possible common e,ological agent for strawberry disease and red mark Schering-Plough Animal Health, UK Possible common e,ological agent for strawberry

  20. Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease

    E-Print Network [OSTI]

    2014-01-01

    Integrative Genomics Reveals Novel Molecular Pathways and7 | e1004502 Integrative Genomics of Coronary Artery Disease2012) Use of functional genomics to identify candidate genes

  1. On the multiscale modeling of heart valve biomechanics in health and disease

    E-Print Network [OSTI]

    Weinberg, Eli J.; Shahmirzadi, Danial; Mofrad, Mohammad Reza

    2010-01-01

    carried out on simulating biomechanics of mechan- ical andmodeling of heart valve biomechanics in health and diseasemodeling of heart valve biomechanics in health and disease

  2. Testing new dairy cattle for disease can boost herd health, cut costs

    E-Print Network [OSTI]

    Moore, Dale A; Adaska, J M; Higginbotham, G E; Castillo, Alejandro R Dr.; Collar, Carol; Sischo, William M

    2009-01-01

    Article t Testing new dairy cattle for disease can boosttest or exam- ine incoming cattle, although these importantin purchased groups of dairy cattle, in order to pro- vide

  3. Psoriasis in a 3-month-old infant with Kawasaki disease

    E-Print Network [OSTI]

    Liao, Yi-Chen; Lee, Julia Yu-Yun

    2009-01-01

    pincer nail deformity. Psoriasis or pityriasis lichenoides2 Figure 1. KD-associated psoriasis in the acute phase of KDFinkelstein Y. Guttate psoriasis following Kawasaki disease.

  4. Diseases associated with hidranitis suppurativa: part 2 of a series on hidradenitis

    E-Print Network [OSTI]

    Scheinfeld, Noah

    2013-01-01

    lower leg of a patient with psoriasis vulgaris. Acta Dermleg of a patient with psoriasis vulgaris.Acta Derm Venereol.Behcet's disease, psoriasis and hidradenitis suppurativa.

  5. A model for the coupled disease dynamics of HIV and HSV-2 with ...

    E-Print Network [OSTI]

    Christina Alvey

    2015-05-19

    May 4, 2015 ... We conclude that homosexual transmission drastically changes the disease prevalences; hence, it is important to account for this interaction as ...

  6. The Human Phenotype Ontology: Semantic Unification of Common and Rare Disease

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Groza, Tudor; Köhler, Sebastian; Moldenhauer, Dawid; Vasilevsky, Nicole; Baynam, Gareth; Zemojtel, Tomasz; Schriml, Lynn Marie; Kibbe, Warren Alden; Schofield, Paul N.; Beck, Tim; et al

    2015-06-25

    The Human Phenotype Ontology (HPO) is widely used in the rare disease community for differential diagnostics, phenotype-driven analysis of next-generation sequence-variation data, and translational research, but a comparable resource has not been available for common disease. Here, we have developed a concept-recognition procedure that analyzes the frequencies of HPO disease annotations as identified in over five million PubMed abstracts by employing an iterative procedure to optimize precision and recall of the identified terms. We derived disease models for 3,145 common human diseases comprising a total of 132,006 HPO annotations. The HPO now comprises over 250,000 phenotypic annotations for over 10,000more »rare and common diseases and can be used for examining the phenotypic overlap among common diseases that share risk alleles, as well as between Mendelian diseases and common diseases linked by genomic location. The annotations, as well as the HPO itself, are freely available.« less

  7. Diseases associated with hidranitis suppurativa: part 2 of a series on hidradenitis

    E-Print Network [OSTI]

    Scheinfeld, Noah

    2013-01-01

    any joint disease of the vertebral column. As such, it is ainvolvement of the vertebral column from any type of joint

  8. The role of phenoloxidase suppression in QX disease outbreaks among Sydney rock oysters

    E-Print Network [OSTI]

    Raftos, David

    disease. Oysters from the same brood stock were harvested from QX prone and QX free growing areas over negative correlation between phenoloxidase activity and the intensity of parasitic infection ( p = 0 prevented effective management of QX disease in endemic areas. Current management regimes rely only

  9. Proceedings of the 2nd workshop on lyme disease in the Southeast

    SciTech Connect (OSTI)

    Apperson, C.S. [ed.] [North Carolina State Univ., Raleigh, NC (United States). Dept. of Entomology; Levine, J.F. [ed.] [North Carolina State Univ., Raleigh, NC (United States). Dept. of Microbiology, Pathology, and Parasitology; Snoddy, E.L. [ed.] [Tennessee Valley Authority, Muscle Shoals, AL (United States)

    1993-12-31

    This volume provides author prepared abstracts of oral presentation at the Second Workshop on Lyme Disease in the Southeast head in Raleigh, North Carolina September 7-9, 1993. The 33 presentations covered various aspects of the epidemic including geographical distribution of various species of ticks, transmission risks, Lyme Disease epidemiology, and taxonomic aspects.

  10. GIS-Based Epidemiological Modeling of an Emerging Forest Disease: Spread of

    E-Print Network [OSTI]

    247 GIS-Based Epidemiological Modeling of an Emerging Forest Disease: Spread of Sudden Oak Death applied in a GIS to real-world wildland landscapes. In this paper, we present and evaluate a GIS model was implemented (1990-2005) in a GIS to simulate disease spread across California at a spatial

  11. Automated segmentation of lungs with severe interstitial lung disease in CT

    E-Print Network [OSTI]

    Automated segmentation of lungs with severe interstitial lung disease in CT Jiahui Wang Department: Accurate segmentation of lungs with severe interstitial lung disease ILD in thoracic computed tomography CT developed in this study a texture analysis-based method for accurate segmentation of lungs with severe ILD

  12. South Carolina Pest Management Handbook for Field Crops -2015 SOYBEAN DISEASE CONTROL

    E-Print Network [OSTI]

    Stuart, Steven J.

    South Carolina Pest Management Handbook for Field Crops - 2015 259 SOYBEAN DISEASE CONTROL John D years. Soybean Rust is active in South Carolina primarily after mid-August in most years. Soybean South Carolina Soybean Production Guide for information on accurate identification of diseases based

  13. Lymphocystis Disease in Fish1 Roy P. E. Yanong, VMD2

    E-Print Network [OSTI]

    Watson, Craig A.

    FA181 Lymphocystis Disease in Fish1 Roy P. E. Yanong, VMD2 1. This document is FA181, one and marine fishes caused by infection with an iridovirus known as Lymphocystivirus or Lymphocystis disease does not cause significant mortalities, it does cause unsightly growths on fish that reduce

  14. Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding

    E-Print Network [OSTI]

    Morimoto, Richard

    Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding Daniela Martino homeostasis components that direct protein folding and function. To identify global principles of misfolding. In diseased cells, maladaptation alters protein structure­function relationships, impacts protein folding

  15. Thesis proposal CSF Brazil 2014 Dendrimers as new drugs against neglected tropical diseases

    E-Print Network [OSTI]

    Bordenave, Charles

    Thesis proposal CSF Brazil 2014 Title: Dendrimers as new drugs against neglected tropical diseases America, particularly in Brazil. The #12;disease is severe in people with weakened immune systems, finding new medications is of high interest both for France and Brazil. We propose to use dendrimers

  16. Asthma is a chronic inflammatory disease of the lungs that is increasingly observed in developed countries

    E-Print Network [OSTI]

    Cai, Long

    Asthma is a chronic inflammatory disease of the lungs that is increasingly observed in developed in the lungs. However, characteristic to both forms of the disease is the airway- wall accumulation of T helper are expressed either by skin8 or lung epithelial cells and can influence the way in which epithelial cells

  17. Assessing Patient Case Management Services with Adult Congenital Heart Disease Sensed Data

    E-Print Network [OSTI]

    Roussos, George

    1 Assessing Patient Case Management Services with Adult Congenital Heart Disease Sensed Data · Clinicians: Doctors & Nurses 7 How do Patients use Panaceia-iTV? Follow a treatment plan that includes-iTV Pilot Sites Brompton Hospital, London Adult Congenital Heart Center, Congenital Heart Disease Patients

  18. New Florida Cattle Identification Program to Protect Florida's Cattle Industry; Mitigate Spread of Disease

    E-Print Network [OSTI]

    Hill, Jeffrey E.

    New Florida Cattle Identification Program to Protect Florida's Cattle Industry; Mitigate Spread. In the past, Florida cattle have struggled with animal disease outbreaks, such as Brucellosis and Tuberculosis and those diseases, present in other states, still threaten our cattle today. The Florida Department

  19. A new shoot and stem disease of Eucalyptus species caused by Erwinia psidii

    E-Print Network [OSTI]

    A new shoot and stem disease of Eucalyptus species caused by Erwinia psidii T. A. Coutinho & C. L Eucalyptus grandis, E. dunnii, E. globulus and E. globulus subsp. maidenii has been observed in plantations previously observed on any species of Eucalyptus. In this study, we describe the symptoms of this new disease

  20. Mycosphaerella leaf disease (MLD) outbreak on Eucalyptus globulus in Brazil caused by Teratosphaeria (Mycosphaerella) nubilosa

    E-Print Network [OSTI]

    302 Mycosphaerella leaf disease (MLD) outbreak on Eucalyptus globulus in Brazil caused of young plantations of Eucalyptus globulus trees showing symptoms resembling My- cosphaerella leaf disease spread of T. nubilosa northwards into Brazil's main Eucalyptus-growing areas as well as to other South