Sample records for alzheimer disease ada

  1. Inside Alzheimer's Disease

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    reveal conditions that lead to the disease's signature tangles and plaques in the brain March 12, 2015 Inside Alzheimer's Disease Neuron membrane disruption may underlie...

  2. alzheimers disease amyloid: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Alzheimer???s Disease Medications. Open Access Theses and Dissertations Summary: ??The brain of Alzheimer???s disease (AD) is characterized by accumulations of ??-amyloid peptide...

  3. alzheimer disease amyloid: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Alzheimer???s Disease Medications. Open Access Theses and Dissertations Summary: ??The brain of Alzheimer???s disease (AD) is characterized by accumulations of ??-amyloid peptide...

  4. New Clues in Predicting Alzheimer's Disease

    ScienceCinema (OSTI)

    Jagust, William

    2013-05-29T23:59:59.000Z

    Theres a new clue in the search to identify the harbingers of Alzheimers disease. More info: http://newscenter.lbl.gov/feature-stories/2008/12/16/predict-alzheimers-disease/

  5. alzheimer disease current: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    diagnosis of Alzheimers disease: CiteSeer Summary: update on combining genetic and brain-imaging measures Gary W. Small, MD Diagnosis of Alzheimers disease is often missed...

  6. S100 Inhibitors: A New Paradigm for Treating Alzheimer’s Disease 

    E-Print Network [OSTI]

    Mathai, David 1991-

    2011-04-27T23:59:59.000Z

    Alzheimer’s disease (AD) is the most common form of dementia, a neurological condition characterized by cognitive impairment and the inability to perform daily tasks. Neuritic protein aggregates in the brain, known as ...

  7. Why Do We Get Alzheimer's Disease?

    SciTech Connect (OSTI)

    Wyss-Coray, Tony (Stanford University) [Stanford University

    2006-01-02T23:59:59.000Z

    Neurodegenerative diseases and Alzheimer's disease (AD) in particular, are among the major health concerns of the elderly in industrialized societies. The cause of AD is unknown and no disease-modifying treatments are available. The disease is characterized clinically by a progressive dementia and pathologically by the accumulation of protein aggregates in the brain and a profound loss of nerve cells. It has also become clear recently that local immune responses are activated in the AD brain and may have a role in the disease. Our laboratory uses genetic mouse models to understand the disease process and to identify potential therapeutic targets.

  8. Educational attainment and rate of cognitive decline in Alzheimer's disease

    E-Print Network [OSTI]

    Hemmy, Laura Sue

    2009-05-15T23:59:59.000Z

    Alzheimer’s disease (AD) progression and hypotheses of the cognitive reserve theory were investigated by testing for a relation between educational attainment and rate of decline in patients with Mild Cognitive Impairment, possible AD, probable AD...

  9. Learning Brain Connectivity of Alzheimer's Disease from Neuroimaging Data

    E-Print Network [OSTI]

    Li, Jing

    Learning Brain Connectivity of Alzheimer's Disease from Neuroimaging Data Shui Huang2 , Jing Li2 Recent advances in neuroimaging techniques provide great potentials for effective diagnosis of Alzheimer. In this paper, we consider the problem of learning functional brain connectivity from neuroimaging, which holds

  10. Journal of Alzheimer's Disease xx (20xx) xxx DOI 10.3233/JAD-132483

    E-Print Network [OSTI]

    Mandal, Pravat K.

    and Alzheimer's Disease as isoprostanes, neuroprostanes, acrolein, and hydrox- ynonenal (HNE), have also been

  11. alzheimers disease neuroimaging: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Learning Brain Connectivity of Alzheimer's Disease from Neuroimaging Data Mathematics Websites...

  12. BONE LOSS IN RELATION TO HYPOTHALAMIC ATROPHY IN ALZHEIMER'S DISEASE

    E-Print Network [OSTI]

    Loskutova, Natalia Y.

    2011-05-12T23:59:59.000Z

    considerable burden on the health system, patients, and caregivers. 1.2 Alzheimer’s Disease and Bone Loss Bone health is an important issue in aging and AD. Osteoporosis–related fractures are among the major health and socioeconomic concerns in aging... of bone fractures, and a determining factor in clinical diagnosis of osteoporosis (Ammann and Rizzoli 2003). Several studies in women suggest that low BMD is associated with poorer cognitive function and subsequent cognitive decline (Yaffe, Browner et al...

  13. Motor signs during the course of Alzheimer disease

    E-Print Network [OSTI]

    to 13.1 years (mean 3.6 years) in five centers in Europe and the United States. MOSIs were rated using signs (MOSIs) are common in Alzheimer disease (AD) and may be associated with rates of cognitive decline a standardized portion of the Unified Parkinson's Disease Rating Scale. Overall, 3,030 visits

  14. Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla

    E-Print Network [OSTI]

    Thompson, Paul

    Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla and Alzheimer's disease based on high resolution MRI at 3 Tesla. T1-weighted images were acquired from 19

  15. Emotion Regulation Deficits in Frontotemporal Lobar Degeneration and Alzheimer's Disease

    E-Print Network [OSTI]

    Levenson, Robert W.

    Emotion Regulation Deficits in Frontotemporal Lobar Degeneration and Alzheimer's Disease Madeleine instructed and spontaneous emotion regulation in patients with frontotemporal lobar degeneration (FTLD, N 32) unwarned without instructions to down-regulate, (b) warned without instructions to down-regulate, and (c

  16. alzheimer disease brain: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    alzheimer disease brain First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Brain MRI segmentation for the...

  17. alzheimers disease brain: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    alzheimers disease brain First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Brain MRI segmentation for the...

  18. Utilization of Fibroblast Steroidogeic Capacity as a Predictive Marker for Alzheimer's Disease

    E-Print Network [OSTI]

    Wisconsin at Madison, University of

    the cause of AD must be related to aging · Figure 1. Sex Hormone Dyscrasia Following Menopause Post, including coronary heart disease, stroke, Alzheimer's disease and osteoporosis. Since circulating

  19. Gist Memory in Alzheimer's Disease: Evidence From Categorized Pictures Andrew E. Budson

    E-Print Network [OSTI]

    Schacter, Daniel

    Gist Memory in Alzheimer's Disease: Evidence From Categorized Pictures Andrew E. Budson Edith of items (gist memory; Reyna & Brainerd, 1995; Schacter, Norman, & Koutstaal, 1998). We have argued

  20. Towards an Objective Assessment of Alzheimer's Disease: The Application of a Novel Evolutionary Algorithm

    E-Print Network [OSTI]

    Fernandez, Thomas

    the way out of a large building. It also affects the drawing of simple three- dimensional geometric shapes countries [4]. The disease occurs when the amyloid -protein forms miliary bodies (plaques) and dense bundles conclusions are drawn in Section 5. 2. ALZHEIMER'S DISEASE Alzheimer's disease (AD) is the most common form

  1. Iron and aluminum interaction with amyloid-beta peptides associated with Alzheimer’s disease

    SciTech Connect (OSTI)

    Drochioiu, Gabi; Ion, Laura [Alexandru Ioan Cuza University of Iasi, 11 Carol I, Iasi 700506 (Romania); Murariu, Manuela; Habasescu, Laura [Petru Poni Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, Iasi 700487 (Romania)

    2014-10-06T23:59:59.000Z

    An elevation in the concentration of heavy metal ions in Alzheimer’s disease (AD) brain has been demonstrated in many studies. A? precipitation and toxicity in AD brains seem to be caused by abnormal interactions with neocortical metal ions, especially iron, copper, zinc, and aluminum [1–3]. There is increasing evidence that iron and aluminum ions are involved in the mechanisms that underlie the neurodegenerative diseases [4,5]. However, evidence was brought to demonstrate that some A? fragments, at physiological pH, are not able to form binary complexes with Fe(III) ions of sufficient stability to compete with metal hydroxide precipitation [6]. On the contrary, multiple metal ions are known to interact with A? peptides [7]. Consequently, we investigated here the interaction of Fe(II/III) and Al(III) ions with some amyloid-? peptides and fragments that results in peptide aggregation and fibrillation [8,9]. Infrared spectroscopy, atomic force microscopy, scanning electron microscopy, electrophoresis and mass spectrometry demonstrated conformational changes of peptides in the presence of such metals.

  2. Seropositivity to Herpes Simplex Virus Antibodies and Risk of Alzheimer's Disease: A Population-Based Cohort

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Seropositivity to Herpes Simplex Virus Antibodies and Risk of Alzheimer's Disease: A Population for Studies in Aging, Montreal, Quebec, Canada Abstract Background: Herpes Simplex Virus (HSV) infection has) Seropositivity to Herpes Simplex Virus Antibodies and Risk of Alzheimer's Disease: A Population-Based Cohort

  3. Innovative Alzheimer's disease clinical trial design in the coming age of biomarkers

    E-Print Network [OSTI]

    Hillerstrom, Hampus

    2008-01-01T23:59:59.000Z

    Alzheimer's disease (AD) is a field with huge unmet need and only a few symptomatic treatments with limited efficacy have been made available to patients. With the testing of disease-modifying drugs in recent years, the ...

  4. Metabonomic Profiling of TASTPM Transgenic Alzheimer's Disease Mouse Model

    SciTech Connect (OSTI)

    Hu, Zeping; Browne, Edward R.; Liu, Tao; Angel, Thomas E.; Ho, Paul C.; Chun Yong Chan, Eric

    2012-12-07T23:59:59.000Z

    Identification of molecular mechanisms underlying early stage Alzheimer’s disease (AD) is important for the development of new therapies against and diagnosis of AD. In this study, non-targeted metabotyping of TASTPM transgenic AD mice was performed. The metabolic profiles of both brain and plasma of TASTPM mice were characterized using gas chromatography-mass spectrometry and compared to those of wild type C57BL/6J mice. TASTPM mice were metabolically distinct compared to wild type mice (Q28 Y = 0.587 and 0.766 for PLS-DA models derived from brain and plasma, respectively). A number of metabolites were found to be perturbed in TASTPM mice in both brain (D11 fructose, L-valine, L-serine, L-threonine, zymosterol) and plasma (D-glucose, D12 galactose, linoleic acid, arachidonic acid, palmitic acid and D-gluconic acid). In addition, enzyme immunoassay confirmed that selected endogenous steroids were significantly perturbed in brain (androstenedione and 17-OH-progesterone) and plasma (cortisol and testosterone) of TASTPM mice. Ingenuity pathway analysis revealed that perturbations related to amino acid metabolism (brain), steroid biosynthesis (brain), linoleic acid metabolism (plasma) and energy metabolism (plasma) accounted for the differentiation of TASTPM and wild-type

  5. Nanoimaging to Prevent and Treat Alzheimer’s and Parkinson’s Diseases. Scientific/Technical report

    SciTech Connect (OSTI)

    Yuri L. Lyubchenko, PhD, DSc

    2012-12-20T23:59:59.000Z

    This project will develop innovative approaches to characterization of the very early stages of protein aggregation that eventually can be translated to the development of early diagnostic tools and efficient treatments for Alzheimer’s, Parkinson’s and Huntington’s diseases. Funding will be used to acquire nanoimaging technology for nanoscale imaging, manipulation and analysis of biomedical materials to develop treatments that will repair disabled proteins and cure diseases that result from protein malfunction, specifically Alzheimer’s and Parkinson’s diseases. Expected outcomes include tests for early diagnosis and therapeutic treatments for these devastating neurological diseases. To elucidate the mechanisms of protein misfolding, we will establish an extensive program of experimental studies using a broad arsenal of advanced nanoscale and traditional techniques that will be integrated with molecular-scale modeling of protein misfolding and the nucleation of aggregate structures. To identify intracellular machinery or/and multicomponent complexes critically involved in protein misfolding, we will characterize interactions between targeted proteins and specific intracellular components or metabolites that impact on protein conformational pathways leading to protein misfolding accompanied by formation of toxic aggregated morphologies. To design innovative nanotechnology tools for the control of intracellular protein misfolding and aggregation processes, we will develop a predictive molecular scale model for intracellular protein misfolding and the formation of toxic aggregates. Verified through experimental studies, the objective is to establish an enabling foundation for the engineering of novel molecular diagnostics and therapeutics for various cellular pathologies.

  6. Oxidative Modifications and Aggregation of Cu,Zn-Superoxide Dismutase Associated with Alzheimer and Parkinson Diseases*

    E-Print Network [OSTI]

    Li, Lian

    to cysteic acid in AD and PD brains. Quantitative Western blot analyses demonstrate that the total level(s) that could potentially be tar- geted by similar therapeutic strategies. Alzheimer disease (AD),1 Parkinson

  7. alzheimer amyloid peptide: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Alzheimer???s Disease Medications. Open Access Theses and Dissertations Summary: ??The brain of Alzheimer???s disease (AD) is characterized by accumulations of ??-amyloid peptide...

  8. alzheimer disease brains: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Brain MRI segmentation for the longitudinal follow-up of regional atrophy in Alzheimers...

  9. Monte Carlo Simulation of Alzheimer's Disease in the United States: 2010-2060

    E-Print Network [OSTI]

    Feres, Renato

    Monte Carlo Simulation of Alzheimer's Disease in the United States: 2010-2060 Michael Blech concerns facing the United States over the next 50 years. This progressive disease is currently the sixth on the United States population, and second, the simulation models both prevalence and mortality. Both

  10. What do family caregivers of Alzheimer's disease patients desire in smart home technologies? Contrasted results of a wide survey.

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 What do family caregivers of Alzheimer's disease patients desire in smart home technologies misuse. Keywords: Smart homes, Dementia care, Alzheimer's disease, Family caregivers, Acceptability. I. Introduction This article presents a survey on the views and perceptions of innovative smart home technologies

  11. Aluminum and silica intake in drinking water and the risk of Alzheimer's disease or cognitive decline: findings of the

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Aluminum and silica intake in drinking water and the risk of Alzheimer's disease or cognitive,2 , Commenges Daniel1,2 , Helmer Catherine2,3 , Jean-François Dartigues2,3 . Abbreviations: Al, Aluminum; AD, Alzheimer's Disease; MMSE, Mini Mental State Examination; Si, Silica Running head: Aluminum, silica in water

  12. Will our final years be golden? Mortality by Alzheimer's disease in the United States

    E-Print Network [OSTI]

    Davis, Mary Ann

    2007-09-17T23:59:59.000Z

    Page A.1 Magnetic Resonance Imaging (MRI) of Brain Atrophy in Alzheimer's Disease........................................................... 125 A.2 Population Pyramid Summary for the United States ............. 126 A.3 Percentage..., Decedents Over Age 60, United States 1998-2002.................................................................... 157 G.2 Frequency of Mortality by Ethnicity in Decedents Over Age 60 in the United States, 1998...

  13. Identifying Alzheimers Disease-Related Brain Regions from Multi-Modality Neuroimaging Data

    E-Print Network [OSTI]

    Li, Jing

    1 Identifying Alzheimers Disease-Related Brain Regions from Multi-Modality Neuroimaging Data using sensitivity and specificity. The fast growing neuroimaging techniques hold great promise.8 Research so far has focused on single neuroimaging modalities. However, as different modalities9 provide complementary

  14. Automated ventricular mapping with multi-atlas fluid image alignment reveals genetic effects in Alzheimer's disease

    E-Print Network [OSTI]

    Thompson, Paul

    in Alzheimer's disease Yi-Yu Chou,a Natasha Leporé,a Greig I. de Zubicaray,b Owen T. Carmichael,c James T. Becker,d Arthur W. Toga,a and Paul M. Thompsona, a Laboratory of Neuro Imaging, Department of Neurology

  15. VENTRICULAR MAPS IN 804 SUBJECTS CORRELATE WITH COGNITIVE DECLINE, CSF PATHOLOGY, AND IMMINENT ALZHEIMER'S DISEASE

    E-Print Network [OSTI]

    Thompson, Paul

    ALZHEIMER'S DISEASE Yi-Yu Chou1 , Natasha Leporé1 , Priya Saharan1 , Sarah K. Madsen1 , Xue Hua1 , Clifford R. Jack2 , Leslie M. Shaw3 , John Q. Trojanowski3 , Michael W. Weiner4 , Arthur W. Toga1 , Paul M

  16. Label-Free Quantitative LC?MS Proteomics of Alzheimer’s Disease and Normally Aged Human Brains

    SciTech Connect (OSTI)

    Andreev, Victor P.; Petyuk, Vladislav A.; Brewer, Heather M.; Karpievitch, Yuliya; Xie, Fang; Clarke, Jennifer; Camp, David G.; Smith, Richard D.; Lieberman, Andrew P.; Albin, Roger L.; Nawaz, Zafar; Hokayem, Jimmy E.; Myers, Amanda J.

    2012-06-17T23:59:59.000Z

    Quantitative proteomics analysis of cortical samples of 10 Alzheimer’s disease (AD) brains versus 10 normally aged brains was performed by following the accurate mass and time tag (AMT) approach with the high resolution LTQ Orbitrap mass spectrometer. More than 1400 proteins were identified and quantitated. A conservative approach of selecting only the consensus results of four normalization methods was suggested and used. A total of 197 proteins were shown to be significantly differentially abundant (p-values <0.05, corrected for multiplicity of testing) in AD versus control brain samples. Thirty-seven of these proteins were reported as differentially abundant or modified in AD in previous proteomics and transcriptomics publications. The rest to the best of our knowledge are new. Mapping of the discovered proteins with bioinformatic tools revealed significant enrichment with differentially abundant proteins of pathways and processes known to be important in AD, including signal transduction, regulation of protein phosphorylation, immune response, cytoskeleton organization, lipid metabolism, energy production, and cell death.

  17. Taurine in drinking water recovers learning and memory in the adult APP/PS1 mouse model of Alzheimer's disease

    E-Print Network [OSTI]

    Kim, Hye Yun

    Alzheimer's disease (AD) is a lethal progressive neurological disorder affecting the memory. Recently, US Food and Drug Administration mitigated the standard for drug approval, allowing symptomatic drugs that only improve ...

  18. Motor signs predict poor outcomes in Alzheimer disease

    E-Print Network [OSTI]

    ) in five University-based AD centers in the United States and European Union. Four outcomes, assessed every index, and death. Using a standardized portion of the Unified PD Rating Scale (administered every 6 disease (AD). Methods: A total of 533 patients with AD at early stages (mean Folstein Mini-Mental State

  19. Longitudinal assessment of global and regional atrophy rates in Alzheimer's disease and dementia with Lewy bodies

    E-Print Network [OSTI]

    Mak, Elijah; Su, Li; Williams, Guy B.; Watson, Rosie

    2015-02-07T23:59:59.000Z

    statistical analysis of atrophy across subjects using SIENAr, an extension of SIENA from the FSL package (Bartsch et al., 2004). Built upon the result of the previous SIENA analy- sis, the edge displacement image was dilated for each subject, trans- formed... with Lewy bodies and Alzheimer3s disease using cortical pattern matching: diagnosis and gender effects. Neuroimage 23 (1), 325–335. http://dx.doi.org/10.1016/j. neuroimage.2004.04.02615325380. Bartsch, A.J., De Stefano, N., Homola, G., Smith, S., 2004...

  20. 3D Local Binary Pattern for PET image classification by SVM Application to early Alzheimer disease diagnosis

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    3D Local Binary Pattern for PET image classification by SVM Application to early Alzheimer disease of Fluorodeoxyglucose PET scans might become a possibility to make early diagnosis more efficient. Temporal and parietal lobes are the main location of medical findings. We have clues that in PET images these lobes contain

  1. AUTOMATIC CLASSIFICATION OF ALZHEIMER'S DISEASE VS. FRONTOTEMPORAL DEMENTIA: A SPATIAL DECISION TREE APPROACH WITH FDG-PET

    E-Print Network [OSTI]

    Utah, University of

    TREE APPROACH WITH FDG-PET N. Sadeghi1 , N. L. Foster2 , A. Y. Wang2 , S. Minoshima3 , A. P. Lieberman4 48109 ABSTRACT We introduce a novel approach for the automatic classifica- tion of FDG-PET scans-- Brain imaging, decision tree, FDG-PET, Alzheimer's Disease, Frontotemporal dementia. 1. INTRODUCTION

  2. Optimizing power to track brain degeneration in Alzheimer's disease and mild cognitive impairment with tensor-based morphometry

    E-Print Network [OSTI]

    Thompson, Paul

    . Leow a,b , Yi-Yu Chou a , April J. Ho a , Boris Gutman a , Arthur W. Toga a , Clifford R. Jack Jr d,j , Gene E. Alexander l , Michael W. Weiner i,j,k,l , Paul M. Thompson a, and the Alzheimer's Disease

  3. What Do Family Caregivers of Alzheimer's Disease Patients Desire in Smart Home Technologies?

    E-Print Network [OSTI]

    Rialle, Vincent; Guigui, Carole; Hervé, Christian

    2009-01-01T23:59:59.000Z

    Objectives - The authors' aim was to investigate the representations, wishes, and fears of family caregivers (FCs) regarding 14 innovative technologies (IT) for care aiding and burden alleviation, given the severe physical and psychological stress induced by dementia care, and the very slow uptake of these technologies in our society. Methods - A cluster sample survey based on a self-administered questionnaire was carried out on data collected from 270 families of patients with Alzheimer's disease or related disorders, located in the greater Paris area. Multiple Correspondence Analysis was used in addition to usual statistical tests to identify homogenous FCs clusters concerning the appreciation or rejection of the considered technologies. Results - Two opposite clusters were clearly defined: FCs in favor of a substantial use of technology, and those rather or totally hostile. Furthermore the distributions of almost all the answers of appreciations were U shaped. Significant relations were demonstrated betwee...

  4. Key residues for the oligomerization of A{beta}42 protein in Alzheimer's disease

    SciTech Connect (OSTI)

    Ngo, Sam [Department of Neurology, Brain Research Institute, Molecular Biology Institute, University of California, Los Angeles, CA 90095 (United States)] [Department of Neurology, Brain Research Institute, Molecular Biology Institute, University of California, Los Angeles, CA 90095 (United States); Guo, Zhefeng, E-mail: zhefeng@ucla.edu [Department of Neurology, Brain Research Institute, Molecular Biology Institute, University of California, Los Angeles, CA 90095 (United States)] [Department of Neurology, Brain Research Institute, Molecular Biology Institute, University of California, Los Angeles, CA 90095 (United States)

    2011-10-28T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer A{beta} oligomers are neurotoxins and likely the causing agents for Alzheimer's disease. Black-Right-Pointing-Pointer A{beta}42 fusion protein form globular oligomers. Black-Right-Pointing-Pointer A{beta}42 fusion protein oligomers contain SDS-resistant tetramers and hexamers. Black-Right-Pointing-Pointer Cysteine substitutions at residues 31, 32, 34, 39-41 disrupt A{beta}42 oligomerization. -- Abstract: Deposition of amyloid fibrils consisting of amyloid {beta} (A{beta}) protein as senile plaques in the brain is a pathological hallmark of Alzheimer's disease. However, a growing body of evidence shows that soluble A{beta} oligomers correlate better with dementia than fibrils, suggesting that A{beta} oligomers may be the primary toxic species. The structure and oligomerization mechanism of these A{beta} oligomers are crucial for developing effective therapeutics. Here we investigated the oligomerization of A{beta}42 in the context of a fusion protein containing GroES and ubiquitin fused to the N-terminus of A{beta} sequence. The presence of fusion protein partners, in combination with a denaturing buffer containing 8 M urea at pH 10, is unfavorable for A{beta}42 aggregation, thus allowing only the most stable structures to be observed. Transmission electron microscopy showed that A{beta}42 fusion protein formed globular oligomers, which bound weakly to thioflavin T and Congo red. SDS-PAGE shows that A{beta}42 fusion protein formed SDS-resistant hexamers and tetramers. In contrast, A{beta}40 fusion protein remained as monomers on SDS gel, suggesting that the oligomerization of A{beta}42 fusion protein is not due to the fusion protein partners. Cysteine scanning mutagenesis at 22 residue positions further revealed that single cysteine substitutions of the C-terminal hydrophobic residues (I31, I32, L34, V39, V40, and I41) led to disruption of hexamer and tetramer formation, suggesting that hydrophobic interactions between these residues are most critical for A{beta}42 oligomerization.

  5. DEVELOPMENT OF AUTOMATED SOFTWARE PROGRAM FOR THE ANALYSIS OF ALZHEIMER'S DISEASE BETA-AMYLOID SCANS

    SciTech Connect (OSTI)

    Mariotti, Jack; Zubal, George

    2013-12-18T23:59:59.000Z

    Study goal: A Phase 1 evaluation of the kinetics, clearance and cerebral distribution of one novel peripheral benzodiazepine receptors(PBR)positron emission tomography (PET) imaging agent, 18F-PBR-111 following intravenous administration in healthy volunteers and Alzheimer's disease (AD) patients. Short title: Evaluation of PET imaging with PBR-111 in HV and AD subjects Proof of Mechanism. Primary Objective: To evaluate the cerebral distribution of PBR-111 positron emission tomography (PET) for detection/exclusion of microglial activation in patients with Alzheimer's disease subjects compared to healthy volunteers. Secondary objectives: - To assess the dynamic uptake and washout of [18F]PBR-111, a potential imaging bio-marker for inflammatory changes in brain, using positron emission tomography in subjects with Alzheimer's disease (AD) and healthy volunteers (HV). - To perform blood metabolite characterization of [18F]PBR-111 in subjects with AD and HV to determine the nature of metabolites in assessment of [18F]-PBR-111 as a PET brain imaging agent. Name of radioactive drug substance: PBR-111 Dose(s): The applied PBR-111 radioactive dose will be up to 5.0 mCi, diluted in a maximum of 10 ml of saline. The radioligand will be administered as a slow intravenous bolus injection (i.e., 6 sec/ml) into a large vein (e.g., antecubital vein). Route of administration: Intravenous injection Duration of treatment: Single administration of a diagnostic agent Indication: PBR-111 positron emission tomography (PET) imaging has the potential to detect microglial activation. In the presence of PBR-111 uptake (representative of microglial activation), inflammation in the brain can be detected. Diagnosis and main criteria for inclusion: Study participants will be HVs and patients diagnosed with probable AD. HVs must be 18 years of age (at least four subjects 50 years of age) and have no evidence of cognitive impairment or other neurologic disease by medical history. The lack of cognitive impairment will also be based on a Clinical Dementia Rating (CDR) of 0. Patients with probable AD must be 50 years of age and must fulfill the National Institute of Neurological and Communicative Disorders and Stroke, Alzheimer's Disease and Related Disorders Association [NINCDS-ADRDA] criteria for probable AD. The CDR score must be 1.0 and 2.0 and have a modified Hachinski of 4. All HVs and all patients with probable AD must be able to comply with all study procedures. Study design: This is a Phase 1, open-label, single-center, non-randomized single dose study to assess the kinetics, clearance and cerebral distribution of PBR-111 PET imaging in detecting microglial activation in the brain in patients with probable AD compared to HVs. All aspects related to image acquisition, processing, and visual as well as quantitative evaluation will be developed, optimized, and validated (where required). Each subject will be required to visit the study center during the screening phase and on the PBR-111 PET imaging day (baseline). A telephone follow-up visit will be performed 7 days (± 3 days) after PBR-111 PET administration. At the screening visit, each subject (or caregiver in the case of AD subjects) will be asked to provide written informed consent or assent. During the screening phase (maximum duration of 60 days) subject medical, neurological, and surgical history, clinical assessments, and a neuro-psychiatric evaluation will be performed on all eligible subjects. Subjects will be allowed to leave the center after all evaluations have been completed. During this period an MRI of the brain will be performed during the screening period. If an MRI of the brain has been performed within six months of the imaging visit using the methods described in the protocol, and there has been no medically significant events in the interim, the previous MRI may be used. During the PBR-111 PET imaging day, all subjects will receive a single intravenous injection of PBR-111 and scanning will be performed over a 3.5 hour period. Each subject will have a telephone follow-up 7 da

  6. Neuronal networks with coupling through amyloid beta: towards a theory for Alzheimer's disease

    E-Print Network [OSTI]

    V. Resmi; G. Ambika; R. E. Amritkar; G. Rangarajan

    2010-11-18T23:59:59.000Z

    Alzheimer's disease (AD) is a common form of dementia observed in the elderly due to neurodegenerative disorder and dysfunction. This arises from alterations in synaptic functioning of neurons leading to cognitive impairment and memory loss. Recent experimental studies indicate that the amyloid beta (A beta) protein, in its dimer and oligomer forms, affects the synaptic activity of neurons in the early stages of AD. However, the precise mechanism underlying A beta induced synaptic depression is still not clearly understood. In this paper, we introduce an electrical model that provides a possible mechanism for this. Our studies show that the competing effects of synaptic activity and the indirect interaction mediated by A beta, can disrupt the synchrony among neurons and severely affect the neuronal activity. This then leads to sub-threshold activity or synaptic silencing. This is in agreement with the reported disruption of cortical synaptic integration in the presence of A beta in transgenic mice. We suggest that direct electrophysiological measurements of A beta activity can establish its role in AD and the possible revival, proposed in our model. The mechanism proposed here is quite general and could account for the role of the relevant protein in other neuronal disorders also.

  7. UncorrectedAuthorProof Journal of Alzheimer's Disease xx (20xx) xxx

    E-Print Network [OSTI]

    30 31 Correspondence to: Jesse Mez, Gertrude H. Sergievsky Center, College of Physicians and Surgeons;UncorrectedAuthorProof 2 J. Mez et al. / Language versus Memory Alzheimer's Subgroups tion of patients with AD

  8. Exploration of the role of gangliosides and cholesterol in the mechanism of ?-amyloid neurotoxicity in Alzheimer's disease

    E-Print Network [OSTI]

    Yoo, Suk Joon

    2002-01-01T23:59:59.000Z

    Submitted to Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE Approved as to the style and content by: Theresa A. Good (Chair of Committee) Gerard L Cote (Member) David M. Ford (Member7-, , g7..., B. S. , Korea University Chair of Advisory Committee Dr. Theresa A. Good Alzheimer's disease (AD) is the most common form of the dementia in the aging population. p-amylotd peptide (Ap l has been indicated as the most important hallmark of AD...

  9. Automatic Classification of Alzheimers Disease vs. Frontotemporal Dementia: A Decision Tree Approach

    E-Print Network [OSTI]

    Utah, University of

    Sadeghi1 , Tolga Tasdizen1 , Norman L. Foster2 , Angela Y. Wang2 , Satoshi Minoshima3 , Andrew P Approach with FDG-PET Neda Sadeghi , Tolga Tasdizen , Norman L. Foster , Angela Y. Wang , Satoshi Minoshima , Andrew P. Lieberman § . School of Computing, University of Utah, Center for Alzheimers Care

  10. A comparative study of synchrony measures for the early diagnosis of Alzheimer's disease based on EEG

    E-Print Network [OSTI]

    Vialatte, François

    Stochastic event synchrony Hilbert transform Wavelet transform It is well known that EEG signals of Alzheimer with an increase of power in the low-frequency range (delta and theta) and a decrease of power in the high. It is noteworthy, however, that those two effects are not always easily detectable: there tends to be large

  11. iCons, 2011 Alzheimers and Aluminum: Lesson Plan

    E-Print Network [OSTI]

    Auerbach, Scott M.

    © iCons, 2011 Alzheimers and Aluminum: Lesson Plan Handouts to explore mechanistic link between Alzheimer's and aluminum 5. Brief proposal expanding Points to Aluminum's Link With Alzheimer's Disease" from 1989. Provide handout

  12. New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc

    E-Print Network [OSTI]

    Corona, C; Pensalfini, A; Frazzini, V; Sensi, S L

    2011-01-01T23:59:59.000Z

    39;s disease: brain deregulation of calcium and zinc [39;s disease: brain deregulation of calcium and zinc39;s disease: brain deregulation of calcium and zinc Gotz

  13. Regional dynamics of -amyloid deposition in healthy elderly, Mild Cognitive Impairment and Alzheimer's disease: a voxelwise PiB-PET longitudinal study

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    and Alzheimer's disease: a voxelwise PiB-PET longitudinal study Nicolas Villain1,2,3,4 , Gaël Chételat1 CHU de Caen, U1077, Caen, France 5. Dept of Nuclear Medicine and Centre for PET, Austin Health, VIC;2 Corresponding author: Victor Villemagne, Department of Nuclear Medicine and Centre for PET, Austin Health, 145

  14. / www.sciencexpress.org / 9 February 2012/ Page 1 / 10.1126/science.1217697 Alzheimer's disease is associated with impaired clearance

    E-Print Network [OSTI]

    Cavusoglu, Cenk

    by apolipoprotein E (ApoE). ApoE expression is transcriptionally induced through the action of the nuclear receptors of Alzheimer's disease resulted in enhanced clearance of soluble A within hours in an apoE- dependent manner factor for sporadic AD is allelic variation in the apolipoprotein E (APOE) gene. Possession of an APOE4

  15. Cyclophilin D Deficiency Rescues Axonal Mitochondrial Transport in Alzheimer’s Neurons

    E-Print Network [OSTI]

    Guo, Lan; Du, Heng; Yan, Shiqiang; Wu, Xiaoping; Mckhann, Guy M.; Chen, John Xi; Yan, Shirley ShiDu

    2013-01-31T23:59:59.000Z

    of synapses relevant to the pathogenesis of Alzheimer’s disease (AD). However, the mechanisms controlling axonal mitochondrial function and transport alterations in AD remain elusive. Here, we report an unexplored role of cyclophilin D (Cyp...

  16. Measuring Dementia of the Alzheimer Type More Precisely

    E-Print Network [OSTI]

    Lowe, Deborah Anne

    2012-11-29T23:59:59.000Z

    Alzheimer’s disease (AD) progressively impairs cognitive and functional abilities. Research on pharmacological treatment of AD is shifting to earlier forms of the disease, including preclinical stages. However, assessment methods traditionally used...

  17. Using yeast to study neurodegenerative diseases : amyloid formation as a protective mechanism and a new Alzheimer's disease model

    E-Print Network [OSTI]

    Treusch, Sebastian

    2011-01-01T23:59:59.000Z

    Numerous neurodegenerative diseases are pathologically characterized by idiosyncratic protein amyloid inclusions. Not surprisingly amyloid fibrils have long been proposed to be the toxic protein species in these neurodegenerative ...

  18. ARTICLE IN PRESS 3 Mapping cortical change in Alzheimer's disease, brain development,

    E-Print Network [OSTI]

    Thompson, Paul

    's disease, schizo- 19 phrenia, normal aging, and abnormal brain development based on 20 imaging data, not seen in individual brain scans, often emerge when 45population-based brain data are averaged School of Medicine, Los Angeles, CA 90095-1769, United States 9 b Child Psychiatry Branch, NIMH, Bethesda

  19. Command Line Arguments in Ada95 Mark Allen Weiss

    E-Print Network [OSTI]

    Weiss, Mark Allen

    Command Line Arguments in Ada95 Mark Allen Weiss School of Computer Science Florida International (additional) arguments: ''­w'' and ''echo args.adb''. These are known as command line arguments. Command line on a command line can be accessed in an Ada program. In Ada83 there was no standard way of doing this. Ada95

  20. ada: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and 2.3 (i, Finalize, Swap, and Display. The package BuiltInTypes supplies these operations for Ada's built-in scalar Initialize, Finalize, Swap, Copy, TestIfEqual and...

  1. Ada Yonath: Another Pioneering Woman in Science

    Broader source: Energy.gov [DOE]

    In honor of Women's History Month, we're highlighting Ada Yonath, whose studies of the structure and function of the ribosome won her a Nobel Prize in Chemistry in 2009.

  2. Early Brain Response to Low-Dose Radiation Exposure Involves Molecular Networks and Pathways Associated with Cognitive Functions, Advanced Aging and Alzheimer's Disease

    SciTech Connect (OSTI)

    Lowe, Xiu R; Bhattacharya, Sanchita; Marchetti, Francesco; Wyrobek, Andrew J.

    2008-06-06T23:59:59.000Z

    Understanding the cognitive and behavioral consequences of brain exposures to low-dose ionizing radiation has broad relevance for health risks from medical radiation diagnostic procedures, radiotherapy, environmental nuclear contamination, as well as earth orbit and space missions. Analyses of transcriptome profiles of murine brain tissue after whole-body radiation showed that low-dose exposures (10 cGy) induced genes not affected by high dose (2 Gy), and low-dose genes were associated with unique pathways and functions. The low-dose response had two major components: pathways that are consistently seen across tissues, and pathways that were brain tissue specific. Low-dose genes clustered into a saturated network (p < 10{sup -53}) containing mostly down-regulated genes involving ion channels, long-term potentiation and depression, vascular damage, etc. We identified 9 neural signaling pathways that showed a high degree of concordance in their transcriptional response in mouse brain tissue after low-dose radiation, in the aging human brain (unirradiated), and in brain tissue from patients with Alzheimer's disease. Mice exposed to high-dose radiation did not show these effects and associations. Our findings indicate that the molecular response of the mouse brain within a few hours after low-dose irradiation involves the down-regulation of neural pathways associated with cognitive dysfunctions that are also down regulated in normal human aging and Alzheimer's disease.

  3. Ada : context-sensitive context-sensing on mobile devices

    E-Print Network [OSTI]

    Chen, Yu-Han, S.M. Massachusetts Institute of Technology

    2013-01-01T23:59:59.000Z

    This thesis describes the design, implementation, and evaluation of Ada, a context-sensing service for mobile devices. Ada explores new points in the accuracy-energy-responsiveness design space for mobile context sensing. ...

  4. Inside Alzheimer's Disease

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of experience, Gonzales is the group's de facto guru. The other three members-Zachary Leonard, Monica Martinez-Archuleta, and Randy Merker-are all former math or science teachers...

  5. A novel approach to the identification and quantitative elemental analysis of amyloid deposits-Insights into the pathology of Alzheimer's disease

    SciTech Connect (OSTI)

    Rajendran, Reshmi; Minqin, Ren [Centre for Ion Beam Applications, Department of Physics, Blk S 12, Faculty of Science, National University of Singapore, 2, Science Drive 3, Singapore 117542 (Singapore)] [Centre for Ion Beam Applications, Department of Physics, Blk S 12, Faculty of Science, National University of Singapore, 2, Science Drive 3, Singapore 117542 (Singapore); Ynsa, Maria Dolores [Centro de Micro-Analisis de Materiales (CMAM), Universidad Autonoma de Madrid, Campus de Cantoblanco, 28049 Madrid (Spain)] [Centro de Micro-Analisis de Materiales (CMAM), Universidad Autonoma de Madrid, Campus de Cantoblanco, 28049 Madrid (Spain); Casadesus, Gemma [Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106 (United States)] [Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106 (United States); Smith, Mark A.; Perry, George [Department of Pathology, Case Western Reserve University, Cleveland, OH 44106 (United States)] [Department of Pathology, Case Western Reserve University, Cleveland, OH 44106 (United States); Halliwell, Barry [Department of Biochemistry, National University of Singapore (Singapore)] [Department of Biochemistry, National University of Singapore (Singapore); Watt, Frank, E-mail: phywattf@nus.edu.sg [Centre for Ion Beam Applications, Department of Physics, Blk S 12, Faculty of Science, National University of Singapore, 2, Science Drive 3, Singapore 117542 (Singapore)] [Centre for Ion Beam Applications, Department of Physics, Blk S 12, Faculty of Science, National University of Singapore, 2, Science Drive 3, Singapore 117542 (Singapore)

    2009-04-24T23:59:59.000Z

    There is considerable interest in the role of metals such as iron, copper, and zinc in amyloid plaque formation in Alzheimer's disease. However to convincingly establish their presence in plaques in vivo, a sensitive technique is required that is both quantitatively accurate and avoids isolation of plaques or staining/fixing brain tissue, since these processes introduce contaminants and redistribute elements within the tissue. Combining the three ion beam techniques of scanning transmission ion microscopy, Rutherford back scattering spectrometry and particle induced X-ray emission in conjunction with a high energy (MeV) proton microprobe we have imaged plaques in freeze-dried unstained brain sections from CRND-8 mice, and simultaneously quantified iron, copper, and zinc. Our results show increased metal concentrations within the amyloid plaques compared with the surrounding tissue: iron (85 ppm compared with 42 ppm), copper (16 ppm compared to 6 ppm), and zinc (87 ppm compared to 34 ppm).

  6. alzheimer type onset: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (up to 80%). The identification of risk factors ... Allen, Mariet 2011-11-25 2 Shift in brain metabolism in late onset Alzheimer's disease: Implications for biomarkers and...

  7. ada compiler system: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in Gypsy Boyer, Robert Stephen 2 Modularization of the DADAISM Ada Database System Architecture Computer Technologies and Information Sciences Websites Summary: Page 1...

  8. act ada accessibility: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    functional encryption, and garbling 113 CryptDB: A Practical Encrypted Relational DBMS Raluca Ada Popa, Nickolai Zeldovich, and Hari Balakrishnan Biology and Medicine...

  9. CD147 is a regulatory subunit of the gamma-secretase complex inAlzheimer's disease amyloid beta-peptide production

    SciTech Connect (OSTI)

    Zhou, Shuxia; Zhou, Hua; Walian, Peter J.; Jap, Bing K.

    2005-04-06T23:59:59.000Z

    {gamma}-secretase is a membrane protein complex that cleaves the {beta}-amyloid precursor protein (APP) within the transmembrane region, following prior processing by {beta}-secretase, producing amyloid {beta}-peptides (A{beta}{sub 40} and A{beta}{sub 42}). Errant production of A{beta}-peptides that substantially increases A{beta}{sub 42} production has been associated with the formation of amyloid plaques in Alzheimer's disease patients. Biophysical and genetic studies indicate that presenilin-1 (Psn-1), which contains the proteolytic active site, and three other membrane proteins, nicastrin (Nct), APH-1, and PEN-2 are required to form the core of the active {gamma}-secretase complex. Here, we report the purification of the native {gamma}-secretase complexes from HeLa cell membranes and the identification of an additional {gamma}-secretase complex subunit, CD147, a transmembrane glycoprotein with two immunoglobulin-like domains. The presence of this subunit as an integral part of the complex itself was confirmed through co-immunoprecipitation studies of the purified protein from HeLa cells and solubilized complexes from other cell lines such as neural cell HCN-1A and HEK293. Depletion of CD147 by RNA interference was found to increase the production of A{beta} peptides without changing the expression level of the other {gamma}-secretase components or APP substrates while CD147 overexpression had no statistically significant effect on amyloid {beta}-peptide production, other {gamma}-secretase components or APP substrates, indicating that the presence of the CD147 subunit within the {gamma}-secretase complex directly down-modulates the production of A{beta}-peptides. {gamma}-secretase was first recognized through its role in the production of the A{beta} peptides that are pathogenic in Alzheimer's disease (AD) (1). {gamma}-secretase is a membrane protein complex with unusual aspartyl protease activity that cleaves a variety of type I membrane proteins, such as APP, CD44, DCC, ErbB4, E-cadherin, LRP, N-cadherin, Nectin-1, and Notch, within their transmembranous regions (2-11); therefore, in addition to its role in AD, {gamma}-secretase has been found to participate in other important biological functions, such as intracellular signaling. {gamma}-secretase processing of APP requires prior removal of a major fragment of the APP extracellular domain (sAPP{sub {beta}}) by {beta}-secretase to yield a membrane bound fragment (APP CTF{sub {beta}}). Subsequent cleavage of this membrane bound fragment by {gamma}-secretase results in the release of the Alzheimer's disease (AD) associated amyloid {beta}-peptides (12). The proteolytic activity of {gamma}-secretase is found not to be critically dependent on the specific sequence, but instead on the size of the extracellular domain (13); such sequence independent characteristics of the substrate are reminiscent of those of the 26S proteasome complex that cleaves substrates in a non-sequence specific manner. {gamma}-secretase is present in almost all animal species, vertebrates and invertebrates; it is expressed in many human organs and tissues.

  10. Ada, Minnesota: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnualProperty Edit withTianlinPapersWindeySanta Clara, California Sector:New Hampshire:Ada

  11. Ada, Oklahoma: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnualProperty Edit withTianlinPapersWindeySanta Clara, California Sector:New Hampshire:AdaOklahoma:

  12. ada holcar slovenia: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and 2.3 (i, Finalize, Swap, and Display. The package BuiltInTypes supplies these operations for Ada's built-in scalar Initialize, Finalize, Swap, Copy, TestIfEqual and...

  13. adenosin deaminasa ada: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    James A Zwiebel; Eli Gilboa; R Michael Blaese; Arthur Nienhuis; Richard J O& apos; reilly; W. French Anderson 1987-01-01 12 ADA: A Language for Robot Programming? Computer...

  14. Formal Modeling of Synchronization Methods forFormal Modeling of Synchronization Methods for Concurrent Objects inConcurrent Objects in Ada 95Ada 95

    E-Print Network [OSTI]

    Xu, Haiping

    isAda programming is to aid engineering of concurrent andto aid engineering of concurrent capabilities to support the engineering of distributed software. One of the principle objectives of concurrent for Concurrent Objects inConcurrent Objects in Ada 95Ada 95 Ravi K. Gedela Dept. of EECS Concurrent Software Lab

  15. Neddylation dysfunction in Alzheimer's disease

    E-Print Network [OSTI]

    Chen, Yuzhi

    Ubiquitin-dependent proteolysis is a major mechanism that downregulates misfolded proteins or those that have finished a programmed task. In the last two decades, neddylation has emerged as a major regulatory pathway for ...

  16. Ohio State ADA Coordinator to Provide Assistance in Indonesia

    E-Print Network [OSTI]

    Howat, Ian M.

    Ohio State ADA Coordinator to Provide Assistance in Indonesia L. Scott Lissner, The Ohio State in Indonesia on disability policy and practice. The trip, from September 15 ­ October 2, 2013, is sponsored, and university professors and students, the U.S. Embassy, along with Helen Keller International Indonesia [a U

  17. Ada County, Idaho: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnualProperty Edit withTianlinPapersWindeySanta Clara, California Sector:New Hampshire:Ada County,

  18. City of Ada, Minnesota (Utility Company) | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual Siteof EnergyInnovationin Urban Transport | OpenChristianCimarronCity & CountyCityAda,

  19. A restudy of the cylindrical amphoras from the seventh-century Yassi Ada shipwreck

    E-Print Network [OSTI]

    Van Alfen, Peter Gerritt

    1995-01-01T23:59:59.000Z

    , this re-examination of the cylindrical amphoras from the Yassi Ada shipwreck provides evidence for a somewhat similar metrological system in use by the 7th c. This restudy of the Yassi Ada cargo also offers a new interpretation of the shipwreck...

  20. The U.S. Equal Employment Opportunity Commission The ADA: Your Reponsibilities as an Employer

    E-Print Network [OSTI]

    Pantaleone, Jim

    The U.S. Equal Employment Opportunity Commission The ADA: Your Reponsibilities as an Employer ADDENDUM Since The Americans with Disabilities Act: Your Responsibilities as an Employer was published to discriminate in employment against a qualified individual with a disability. The ADA also outlaws

  1. The U.S. Equal Employment Opportunity Commission The ADA: Your Employment Rights as an Individual

    E-Print Network [OSTI]

    Pantaleone, Jim

    The U.S. Equal Employment Opportunity Commission The ADA: Your Employment Rights as an Individual With a Disability The Americans with Disabilities Act of 1990 (ADA) makes it unlawful to discriminate in employment is enforced by the U.S. Equal Employment Opportunity Commission and State and local civil rights enforcement

  2. Free membership Agriculture Alzheimer Astronomy

    E-Print Network [OSTI]

    Lovley, Derek

    Membership Free membership signup! Categories Agriculture Alzheimer Astronomy Astrophysics Bacteria that was released to the environment as a result of ore milling, nuclear fuel fabrication or processing activities

  3. Patterns of Cognitive Decline in Alzheimer's Dementia: An Application of Hierarchical Bayesian Multiphase Models

    E-Print Network [OSTI]

    Langford, Zachary Denver

    2012-12-31T23:59:59.000Z

    As the Alzheimer's disease process progresses in time measurements of cognitive functioning exhibit nonlinearity. Multiphase models were used to quantify this nonlinearity for thirty-six well characterized individuals(~12 observations per individual...

  4. U.S. Environmental Protection Agency's Robert S. Kerr Environmental Research Center, Ada, Oklahoma

    SciTech Connect (OSTI)

    Farrar-Nagy, S.; Voss, P.; Van Geet, O.

    2006-10-01T23:59:59.000Z

    U.S. EPA's Robert S. Kerr Environmental Research Center, Ada, Oklahoma, has reduced its annual energy consumption by 45% by upgrading its building mechanical system and incorporating renewable energy.

  5. Body Composition in Early Alzheimer's Disease

    E-Print Network [OSTI]

    Burns, Jeffrey M.

    2009-01-09T23:59:59.000Z

    measures of memory (WMS-R Logical Memory I and II, Free and Cued Selective Reminding Task), language (Boston Naming Test ? 15 item), working memory (WMS III Digit Span Forwards and Backwards, WAIS Letter-number sequencing), executive function...

  6. Longitudinal Medication Usage in Alzheimer Disease Patients

    E-Print Network [OSTI]

    on ChEIs.1,5­8 In addition to ChEIs and memantine, AD patients are likely to be prescribed other examined in detail patterns of cholinesterase inhibitors (ChEIs) and memantine use and explored characteristics on ChEIs/ memantine use over time. Independent variables included measures of function, cognition

  7. EVALUATION OF THE ADA TECHNOLOGIES' ELECTRO-DECON PROCESS TO REMOVE RADIOLOGICAL CONTAMINATION

    SciTech Connect (OSTI)

    Pao, Jenn-Hai; Demmer, Rick L.; Argyle, Mark D.; Veatch, Brad D.

    2003-02-27T23:59:59.000Z

    A surface decontamination system featuring the use of ADA's electrochemical process was tested and evaluated. The process can be flexibly deployed by using an electrolyte delivery system that has been demonstrated to be reliable and effective. Experimental results demonstrate the effectiveness of this system for the surface decontamination of radiologically contaminated stainless steel.

  8. AEDC-TR-91-24 AD-A244 075

    E-Print Network [OSTI]

    McLachlan, Robert

    AEDC-TR-91-24 AD-A244 075 Asymptotic Theory of Transonic Wind Tunnel Wall Interference N. D-00201 ARNOLD ENGINEERING DEVELOPMENT CENTER ARNOLD AIR FORCE BASE, TENNESSEE AIR FORCE SYSTEMS COMMAND UNITED STATES AIR FORCE #12;NOTICES When U. S. Government drawings, specifications, or other data are used

  9. CryptDB: A Practical Encrypted Relational DBMS Raluca Ada Popa, Nickolai Zeldovich, and Hari Balakrishnan

    E-Print Network [OSTI]

    Sabatini, David M.

    CryptDB: A Practical Encrypted Relational DBMS Raluca Ada Popa, Nickolai Zeldovich, and Hari Balakrishnan {raluca, nickolai, hari}@csail.mit.edu ABSTRACT CryptDB is a DBMS that provides provable. When individual users or enterprises store their sensitive data in a DBMS today, they must trust

  10. Inflammation as a potential mediator for the association between periodontal disease and Alzheimer’s disease

    E-Print Network [OSTI]

    Watts, Amber; Crimmins, Eileen M.; Gatz, Margaret

    2008-09-10T23:59:59.000Z

    antibodies (Aiello et al 2006). HSV-1 is found in a high proportion of non-AD elderly brains (Jamieson et al 1992) and is most often not found to be associated with dementia. This does not preclude the role of HSV in AD, because presence of a virus... health does not improve despite treatment and proper hygiene, release higher levels of IL-1? and prostaglandin-E2 than patients with non- refractory periodontitis (Hernichel-Gorbach et al 1994). Polymorphisms for genes involved in inflammatory process...

  11. Faster Cognitive and Functional Decline in Dysexecutive versus Amnestic Alzheimer's Subgroups: A Longitudinal

    E-Print Network [OSTI]

    : A Longitudinal Analysis of the National Alzheimer's Coordinating Center (NACC) Database Jesse Mez1: A dysexecutive subgroup of AD has a unique disease course in addition to cognitive phenotype. Citation: Mez J June 3, 2013 Copyright: ß 2013 Mez et al. This is an open-access article distributed under the terms

  12. Locomotive Micro-Implant with Active Electromagnetic Propulsion Daniel Pivonka, Ada S. Y. Poon, and Teresa H. Meng

    E-Print Network [OSTI]

    Poon, Ada

    Locomotive Micro-Implant with Active Electromagnetic Propulsion Daniel Pivonka, Ada S. Y. Poon An active locomotive technique requiring only an ex- ternal power source and a static magnetic field is pre- sented, and its operation is analyzed and simulated. For a modest static MRI magnetic field of 1 T

  13. RAGE and Alzheimer’s Disease: A Progression Factor for Amyloid-?-Induced Cellular Perturbation?

    E-Print Network [OSTI]

    Yan, Shirley ShiDu; Bierhaus, Angelika; Nawroth, Peter P.; Stern, David M.

    2009-04-01T23:59:59.000Z

    Receptor for Advanced Glycation Endproducts (RAGE) is a multiligand member of the immunoglobulin superfamily of cell surface molecules which serves as a receptor for amyloid-? peptide (A?) on neurons, microglia, astrocytes, ...

  14. Sense of identity in Alzheimer's Disease Sense of identity in advanced Alzheimer's dementia: a cognitive

    E-Print Network [OSTI]

    Boyer, Edmond

    (AD) and if its profile remains the same between two examinations. A specifically designed protocol was administered to 16 AD patients in the mild to severe stages of dementia and to 16 matched healthy controls patients. The patterns of their responses were similar to those of controls, and remained consistent over

  15. S100 Inhibitors: A New Paradigm for Treating Alzheimer’s Disease

    E-Print Network [OSTI]

    Mathai, David 1991-

    2011-04-27T23:59:59.000Z

    identified, this mechanistic information can be used toward the development of S100 inhibitors that improve memory loss in patients. The availability of novel pharmacological interventions for AD will significantly reduce the monetary and societal impacts...

  16. Macrophages in Alzheimer’s disease: the blood-borne identity

    E-Print Network [OSTI]

    Gate, David; Rezai-Zadeh, Kavon; Jodry, Dominique; Rentsendorj, Altan; Town, Terrence

    2010-01-01T23:59:59.000Z

    limited capacity to divide (Graeber et al. 1992; Kennedy andImmu- nity 19(1):71–82 Graeber MB, Streit WJ, Buringer D,

  17. Insight into Alzheimer's, cancer, anemia gleaned from ribosome...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Insights from ribosome research Insight into Alzheimer's, cancer, anemia gleaned from ribosome research Groundbreaking study of the human ribosome reveals tiny molecular machine is...

  18. What is new and exciting in Alzheimer's disease research?

    E-Print Network [OSTI]

    Jonsson1 et al., Nature | Letter 2012 1deCODE genetics, 101 Reykjavik, Iceland #12;#12;Alan Turing) at the National Codes Centre at Bletchley Park In 2012 two 70-year-old papers by Alan Turing on the theory of code

  19. Introduction Alzheimer's disease (AD) is the most common type of

    E-Print Network [OSTI]

    Appanna, Vasu

    of methionine (MET), 5- hydroxyindoleacetic acid (5-HIAAA), vanillylmandelic acid and xanthosine (8 disturbances in glycolytic glucose breakdown, pyruvate oxidation as well as excessive protein degradation

  20. A State-Wide Research Network for Alzheimer's Disease

    SciTech Connect (OSTI)

    Mintzer, Jacobo E.; Bachman, D. L.; Stuckey, M.; Ebeling, M.; Wagner, M. T.; Evans, W. J.; Hirth, V.; Walker, A.; Joglekar, R.; Faison, W.

    2014-03-13T23:59:59.000Z

    The Specific Aim of the proposal was to develop an administrative structure that will facilitate the development of AD research across the state of SC by providing key services such as (but not limited to) seeking funding research opportunities, financial tracking, regulatory management, central recruitment, training for investigators and coordinators, data collection, data storing, and data processing to researchers across the state.

  1. Introduction Alzheimer's disease (AD) has an apparent multifactoral

    E-Print Network [OSTI]

    Graves, Michael V.

    methylation of proteins, phospholipids, neurotransmitters and nucleic acids. In addition, S,9-11). Transgenic mice homozygously-lacking apolipoprotein E (ApoE-/-; 12-14) undergo markedly more severe oxidative damage and cognitive impairment when maintained on a folate-deficient diet than do normal mice (15

  2. alzheimer disease pathology: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and temporomandibular joints resulted in astrocyte and microglial activation in the brain, accompanied by upregulation of inflammation-related gene expression. The biological...

  3. alzheimer disease patients: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Lana became her fathers primary caregiver, even as she was starting a career and family. For several years after his diagnosis, Bakers father was able to live in his own...

  4. alzheimers disease patients: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Lana became her fathers primary caregiver, even as she was starting a career and family. For several years after his diagnosis, Bakers father was able to live in his own...

  5. alzheimers disease caregivers: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    families what they are doing that merits that designation. She also pushed legislation to protect a couples financial assets when one is receiving Medicaid home- and...

  6. DISEASE-SPECIFIC PROBABILISTIC BRAIN ATLASES

    E-Print Network [OSTI]

    Thompson, Paul

    algorithms for knowledge-based image analysis, automated image labeling, tissue classification, data mining School of Medicine, Los Angeles, CA 2 Alzheimer's Disease Center, UCLA School of Medicine, Los Angeles Westwood Plaza, Los Angeles, CA 90095-1769 Phone: (310) 206-2101 Fax: (310) 206-5518 E-mail: thompson

  7. Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model

    E-Print Network [OSTI]

    Brinton, Roberta Diaz

    Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model and suggests therapeutic targets for prevention of AD. ABAD aging bioenergetics brain hypometabolism mitochondria The essential role of mitochondria in cellular bioenergetics and survival has been well

  8. Alzheimer caregiving stress and atherosclerotic disease : psychosocial and physiological pathways linking chronic stress to disease

    E-Print Network [OSTI]

    Buehler, Susan Kyung; Buehler, Susan Kyung

    2012-01-01T23:59:59.000Z

    Medicine, 52(3-4), 208-212. O'Leary, D. H. , Polak, J. F. ,A. , Sidney, S. , & O'Leary, D. H. (2010). Segment-specificand myocardial infarction (O'Leary et al. , 1999). Moreover,

  9. ADA Retrofit and Construction

    E-Print Network [OSTI]

    Minnesota, University of

    Design vs. Construction § Case Studies § City of Richfield's Transition Plan #12;How Detailed Should survey "tough" intersections § Smart level & tape measure for "easy" intersections Case Study Breckenridge, MN #12;Case Study Breckenridge, MN #12;Case Study Breckenridge, MN #12;Case Study Breckenridge

  10. ECE567/BME532 MODERN BIOMEDICAL IMAGING Instructor: Dr. Ying (Ada) Chen E-mail: adachen@siu.edu

    E-Print Network [OSTI]

    Chen, Ying "Ada"

    of various diseases in modern society. The rapid advances in medical imaging technology make it possible to create high-resolution, three-dimensional anatomical and physiological images to enable powerful advances Textbook and references Textbook: The Essential Physics of Medical Imaging (2nd Edition), J. T. Bushberg, J

  11. Crude caffeine reduces memory impairment and amyloid b142 levels in an Alzheimer's mouse model

    E-Print Network [OSTI]

    Lockery, Shawn

    Crude caffeine reduces memory impairment and amyloid b1­42 levels in an Alzheimer's mouse model Yi the elderly. Crude caffeine (CC), a major by-product of the decaffeination of coffee, has potent hydrophilic

  12. Alzheimer's amyloid-? and the disordered structural ensemble characterized using molecular dynamics and NMR spectroscopy

    E-Print Network [OSTI]

    Ball, Katherine Aurelia

    2013-01-01T23:59:59.000Z

    NL et al. (2008) Structure and dynamics of the Abeta(21-30)study of the structure and dynamics of the Alzheimer'sShaw DE (2012) Structure and dynamics of an unfolded protein

  13. Frontiers in Disease Therapies UCSB's integration of critical aspects of biological engineering (drug delivery, systems biology, biomateri-

    E-Print Network [OSTI]

    Akhmedov, Azer

    the many diseases that UCSB has cross-disciplinary efforts in, including cancer, diabetes, PTSD, Alzheimer targeting therapeutics to cancer cells while sparing healthy ones. In cancer and diabetes, another failure diabetic patients using closed-loop devices in clinical trials. For more insight into our approach

  14. Genetic Studies of Complex Human Diseases: Characterizing SNP-Disease Associations Using Bayesian Networks

    E-Print Network [OSTI]

    Han, Bing; Chen, Xue-wen; Talebizadeh, Zohreh; Xu, Hua

    2012-12-17T23:59:59.000Z

    (Suppl 3):S14 http://www.biomedcentral.com/1752-0509/6/S3/S14 © 2012 Han et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2...) heuristic search method can solve the classical XOR (Exclusive or) pro- blem [14]. We apply the EpiBN method to simulated datasets based on four disease models and three real datasets: Age-related Macular Degeneration (AMD) dataset, late-onset Alzheimer...

  15. Brain Imaging with Positron Emission Tomography: Quantification and Biomedical Applications in Alzheimer's Disease and Brain Tumors

    E-Print Network [OSTI]

    Wardak, Mirwais

    2013-01-01T23:59:59.000Z

    a kinetic microarray, similar to how gene expression levelsof gene expression (1, 13-19). The tracer kinetic method is

  16. Brain Imaging with Positron Emission Tomography: Quantification and Biomedical Applications in Alzheimer's Disease and Brain Tumors

    E-Print Network [OSTI]

    Wardak, Mirwais

    2013-01-01T23:59:59.000Z

    via inhalation into the lungs, direct injection into thebilateral metastasis to the lung (arrow) from a previousproduces poor images of the lung, is not able to show

  17. Estrogen regulation of glucose metabolism and mitochondrial function: Therapeutic implications for prevention of Alzheimer's disease

    E-Print Network [OSTI]

    Brinton, Roberta Diaz

    glycolysis and citric acid cycle-driven oxidative phosphorylation and ATP generation. Data derived from, enhanced glycolysis coupled to the citric acid cycle (aerobic glycolysis), sustained and enhanced glycolysis (oxidative phosphorylation coupled to pyruvate metabolism). The enhanced aerobic glycolysis

  18. DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    al. Figure 3 Epigenetic deregulation of target genes in the3027 Figure 2 Epigenetic deregulation of target genes in

  19. Brain Imaging with Positron Emission Tomography: Quantification and Biomedical Applications in Alzheimer's Disease and Brain Tumors

    E-Print Network [OSTI]

    Wardak, Mirwais

    2013-01-01T23:59:59.000Z

    AB, Elson LM. The human brain coloring book. 1st ed. New21. Toga AW, Mazziotta JC. Brain mapping : the systems. SanSR, Phelps ME. Imaging Brain Function with Positron Emission

  20. DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    PLoS One 2009; 2: e895. Song CX, Szulwach KE, Fu Y, Dai Q,Szulwach KE, Li X, Li Y, Song CX, Wu H, Dai Q, et al. 5-hmC-cells), cerebral cortex (CX, CA1, CA3 and den- tate gyrus)

  1. MCI CONFERENCE PAPER HORMONAL TREATMENT, MILD COGNITIVE IMPAIRMENT, AND ALZHEIMER'S DISEASE

    E-Print Network [OSTI]

    Boyer, Edmond

    lost at menopause would prevent many of the manifestations of aging, including osteoporosis on the neurotransmitter systems implicated in cognition. Recent hormonal replacement therapy trials in non- demented post-menopausal to the widespread use of Hormone Replacement Therapy (HT) after the menopause, but following the recent publication

  2. Synchronizing an aging brain: can entraining circadian clocks by food slow Alzheimer's disease?

    E-Print Network [OSTI]

    Kent, Brianne A.

    2014-09-01T23:59:59.000Z

    in the external environment. When the SCN is unable to entrain to light-dark cycles, such as when the SCN is experimentally ablated or an animal is in con- ditions of constant darkness, daylight no longer acts as a zeitgeber and circadian organization gradually... . The behavioral arrhythmia was not due to a failing central clock. If these findings translate to AD patients, then it would suggest that the SCN would stay entrained to daylight while the peripheral rhythms affecting behavior become out of sync. If circadian...

  3. Brain Imaging with Positron Emission Tomography: Quantification and Biomedical Applications in Alzheimer's Disease and Brain Tumors

    E-Print Network [OSTI]

    Wardak, Mirwais

    2013-01-01T23:59:59.000Z

    HC, Ysaguirre T, inventors; Siemens Medical Solutions USA,HC, Ysaguirre T, inventors; Siemens Medical Solutions USA,ECAT EXACT HR+ PET scanner (Siemens/CTI, Inc. ) consists of

  4. Brain Imaging with Positron Emission Tomography: Quantification and Biomedical Applications in Alzheimer's Disease and Brain Tumors

    E-Print Network [OSTI]

    Wardak, Mirwais

    2013-01-01T23:59:59.000Z

    of tumors with only modest increases in glucose metabolism (of tumors with only modest increases in glucose metabolism,

  5. Multiple Events Lead to Dendritic Spine Loss in Triple Transgenic Alzheimer's Disease Mice

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    amyloid deposition leads to local synaptic abnormalities andMultiple Events Lead to Dendritic Spine Loss in Tripleal. (2010) Multiple Events Lead to Dendritic Spine Loss in

  6. APOE associated hemispheric asymmetry of entorhinal cortical thickness in aging and Alzheimer's disease

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    with developmental dyslexia. Brain and Language 39, 289–301.asymmetry reductions in dyslexia patients or gender-

  7. Microstructural white matter changes in Alzheimer's disease : a diffusion tensor imaging study

    E-Print Network [OSTI]

    Horne, Nikki Renee

    2008-01-01T23:59:59.000Z

    CP = cerebral peduncles, FSRP = Framingham Stroke Riskimaging FOV field of view FSRP Framingham Stroke RiskStroke Risk Profile (FSRP, D'Agostino, Wolf, Belanger, &

  8. Multiple Events Lead to Dendritic Spine Loss in Triple Transgenic Alzheimer's Disease Mice

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    Simon M. Ochs 1 , Nadine Hoffmann 1 , Gerda Mitteregger 1 ,M, Burgold S, Ochs SM, Hoffmann N, et al. (2010) Multiple

  9. Targeting the brain : identifying and inhibiting harmful protein-amyloid interactions in Alzheimer's disease

    E-Print Network [OSTI]

    Habib, Lila K.

    2011-01-01T23:59:59.000Z

    dishes (MatTek Co. , Ashland, MA) and incubated overnight.collagen (MatTek Co. , Ashland, MA) and incubated overnightdishes (MatTek Co. , Ashland, MA) and incubated overnight.

  10. Associations between potentially modifiable risk factors and Alzheimer's disease: A Mendelian random

    E-Print Network [OSTI]

    Østergaard, Søren D.; Mukherjee, Shubhabrata; Sharp, Stephen J.; Proitsi, Petroula; Lotta, Luca A.; Day, Felix; Perry, John R. B.; Boehme, Kevin L.; Walter, Stefan; Kauwe, John S.; Gibbons, Laura E.; Alzheimer’s Disease Genetics Consortium; The Genetic and Environmental Risk in AD Consortium; The EPIC-InterAct consortium; Larson, Eric B.; Powell, John F.; Laugenberg, Claudia; Crane, Paul K.; Wareham, Nicholas J.; Scott, Robert A.

    2015-06-09T23:59:59.000Z

    of insulin resistance and body fat distribution in type 2 diabetes, independently of obesity. Diabetes. 2014. 16. Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, et al. Association analyses of 249,796 individuals reveal 18 new... with autopsy-confirmed diagnosis and no clinical diagnosis, the age at death was used for age at diagnosis. For all studies, the age used for CNEs was the age of last exam or age at death for those for whom age at exam was not available. Case and CNE subjects...

  11. A Novel Sensitive Method of Detecting Mnemonic Decline in Mouse Model of Alzheimer's Disease

    E-Print Network [OSTI]

    Simmons, Rebecca

    2011-01-11T23:59:59.000Z

    in initial discrimination learning or on the ability to ransfer this learned information to the altered context. In contrast, at 12 months of age, APP+PS1 mice learned the initial concurrent discriminations on par with iv NTgs but were impaired when... involves nondemented patients on a series of eight concurrent discriminations with each pair consisting of two objects that vary in color or two colors that vary in shape. Therefore, each pair consists of a relevant and irrelevant feature. Patients...

  12. In Vivo Characterization of CLR01, an Aggregation and Toxicity Inhibitor, with an Alzheimer's Disease Focus

    E-Print Network [OSTI]

    Attar, Aida

    2013-01-01T23:59:59.000Z

    structural basis of protein folding and its links with human93. Dobson CM (2003) Protein folding and misfolding. NatureCM (2004) Principles of protein folding, misfolding and

  13. Microstructural white matter changes in Alzheimer's disease : a diffusion tensor imaging study

    E-Print Network [OSTI]

    Horne, Nikki Renee

    2008-01-01T23:59:59.000Z

    62(10), 1862-1864. Van Petten, C. (2004). Relationship42(10), 1394-1413. Van Petten, C. , Plante, E. , Davidson,regions (Raz, 2005; Van Petten et al. , 2004). This pattern

  14. Journal of Alzheimer's Disease 14 (2008) 235245 235 Three-Dimensional Tomographic Imaging

    E-Print Network [OSTI]

    Dunin-Borkowski, Rafal E.

    2008-01-01T23:59:59.000Z

    , Cleveland Ohio, USA f College of Sciences, University of Texas at San Antonio, San Antonio, Texas, USA g microscopy (HR-TEM), energy dispersive X-ray (EDX) spectroscopy and electron energy-loss spectroscopy (EELS of these important roles, iron can also be toxic, with certain forms participating in the production of free radicals

  15. Impaired Adult Neurogenesis in the Dentate Gyrus of a Triple Transgenic Mouse Model of Alzheimer's Disease

    E-Print Network [OSTI]

    2008-01-01T23:59:59.000Z

    Masashi Tabuchi 1 , Stuart M. Allan 1 , Elysse M. Knight 1 ,JJ, Jones VC, Tabuchi M, Allan SM, Knight EM, et al. (2008)

  16. Sleep and markers of cardiovascular disease risk in elderly Alzheimer's caregivers

    E-Print Network [OSTI]

    Schwartz, Jennifer

    2012-01-01T23:59:59.000Z

    14. Vgontzas AN, Liao D, Bixler EO, Chrousos GP, Vela-BuenoVgontzas AN, Tsigos C, Bixler EO, et al. Chronic insomnia14. Vgontzas AN, Liao D, Bixler EO, Chrousos GP, Vela-Bueno

  17. Body mass index is associated with biological CSF markers of core brain pathology of Alzheimer's disease

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    Schneider JA, Leurgans S, Bennett DA. Physical frailty inJA, Wilson RS, Bienias JL, Bennett DA. Body mass index inFitzpatrick e , David Bennett f , Lennart Minthun d , John

  18. Brain Imaging with Positron Emission Tomography: Quantification and Biomedical Applications in Alzheimer's Disease and Brain Tumors

    E-Print Network [OSTI]

    Wardak, Mirwais

    2013-01-01T23:59:59.000Z

    and the combination of PET and CT into one imaging system (dose (35). Since the PET and CT components are attachedionizing radiation (unlike PET and CT), provides excellent

  19. Brain Imaging with Positron Emission Tomography: Quantification and Biomedical Applications in Alzheimer's Disease and Brain Tumors

    E-Print Network [OSTI]

    Wardak, Mirwais

    2013-01-01T23:59:59.000Z

    but may also lead to a loss of information and even uselesscan also lead to a loss in the information content contained

  20. A novel invertebrate chordate model for Alzheimer's disease using the ascidian ciona intestinalis

    E-Print Network [OSTI]

    Virata, Michael J.

    2009-01-01T23:59:59.000Z

    H (2006) Regulation of tyrosinase trafficking and processingthe pigment cell marker tyrosinase (data unpublished) haverole in both regulating tyrosinase activity, a biosynthetic

  1. Sleep and markers of cardiovascular disease risk in elderly Alzheimer's caregivers

    E-Print Network [OSTI]

    Schwartz, Jennifer

    2012-01-01T23:59:59.000Z

    30(12):645-52. Espeland MA, O'Leary D H, Terry JG, Morgan T,82(4):1230-42. Espeland MA, O'Leary D H, Terry JG, Morgan T,circulation 2004;35(9):2150-4. O'Leary DH, Polak JF, Kronmal

  2. DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT

    E-Print Network [OSTI]

    Jones, Rob; Sheehan, Bart; Phillips, Patrick; Juszczak, Ed; Adams, Jessica; Baldwin, Ashley; Ballard, Clive; Banerjee, Sube; Barber, Bob; Bentham, Peter; Brown, Richard; Burns, Alistair; Dening, Tom; Findlay, David; Gray, Richard; Griffin, Mary; Holmes, Clive; Hughes, Alan; Jacoby, Robin; Johnson, Tony; Jones, Roy; Knapp, Martin; Lindesay, James; McKeith, Ian; McShane, Rupert; Macharouthu, Ajay; O'Brien, John; Onions, Caroline; Passmore, Peter; Raftery, James; Ritchie, Craig; Howard, Rob; Domino-ad Team

    2009-07-24T23:59:59.000Z

    ) factorial (2 × 2) design, whether there is worthwhile ben- efit for patients, for whom there is uncertainty on whether related quality of life after 12 months compared to those patients continuing on either monotherapy; Trials 2009, 10:57 http... and health related quality of life. Methods Design This is a pragmatic, multicentre, double-blind (with patient, carer, clinician, outcome assessor and investiga- tors blinded), randomized, placebo controlled (double dummy), parallel group, 2 × 2 factorial...

  3. UNCORRECTEDPROOF 2 3D characterization of brain atrophy in alzheimer's disease and mild

    E-Print Network [OSTI]

    Thompson, Paul

    ,a Arthur W. Toga,a Natasha Lepore,a 5 Yi-Yu Chou,a Caroline Brun,a Ming-Chang Chiang,a Marina Barysheva Harvey,e John Kornak,f Norbert Schuff,g Lauren Boreta,g Gene E. Alexander,i 9 Michael W. Weiner,g,h Paul

  4. THREE-DIMENSIONAL STRUCTURE OF THE LITHOSTATHINE PROTOFIBRIL, A PROTEIN INVOLVED IN ALZHEIMER'S DISEASE

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    interactions into a tetramer. Each tetramer then linked up with another tetramer as the result of longitudinal

  5. 3D structure of Alzheimer's amyloid-{beta}(1-42) fibrils Dbeli, David Schubert, and Roland Riek

    E-Print Network [OSTI]

    Riek, Roland

    3D structure of Alzheimer's amyloid-{beta}(1-42) fibrils Döbeli, David Schubert, and Roland Riek.pnas.org/misc/reprints.shtml To order reprints, see: Notes: #12;3D structure of Alzheimer's amyloid- (1­42) fibrils Thorsten Lu¨ hrs fibrils (2, 3). Only one 3D structure of an engineered amyloid fibril has yet been determined (4), owing

  6. Information Regarding MENINGOCOCCAL DISEASE

    E-Print Network [OSTI]

    . Meningococcal disease is a serious disease, caused by bacteria. Meningococcal disease is a contagious

  7. In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer¿s disease pathology

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    Departamento de Biologia Celular, Genetica y Fisiologia,Departamento de Biologia Celular, Genetica y Fisiologia,

  8. GPR50, a potential factor involved in psychiatric disorders interacts with Alzheimer’s disease-related protein ?- secretase (BACE1) 

    E-Print Network [OSTI]

    Li, Qian

    2014-11-28T23:59:59.000Z

    GPR50, an X-linked orphan G protein-coupled receptor (GPCR), is a risk factor for bipolar disorder (BD) in female subjects. It has been shown that GPR50 plays a part in neurite outgrowth, glucocorticoid receptor signalling ...

  9. Simultaneous Segmentation and Grading of Hippocampus for Patient Classification with Alzheimer's

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Simultaneous Segmentation and Grading of Hippocampus for Patient Classification with Alzheimer library used during our experiments was composed by 2 populations, 50 Cognitively Normal subjects (CN of the HC at the same time resulted in an efficient patient classification with a success rate of 90

  10. ALZHEIMER'S AMYLOID-BETA PEPTIDE INHIBITS SODIUM/CALCIUM EXCHANGE MEASURED IN RAT AND

    E-Print Network [OSTI]

    ALZHEIMER'S AMYLOID-BETA PEPTIDE INHIBITS SODIUM/CALCIUM EXCHANGE MEASURED IN RAT AND HUMAN BRAIN-beta1­40 (A 1­40) and A 25­35 reduced vesicular Ca2+ content. Both peptides produced a maximal reduction in Ca2+ content of approximately 50%. The peptides reduced Ca2+ content with similar potency and half

  11. Pesticides and human chronic diseases: Evidences, mechanisms, and perspectives

    SciTech Connect (OSTI)

    Mostafalou, Sara; Abdollahi, Mohammad, E-mail: Mohammad.Abdollahi@UToronto.Ca

    2013-04-15T23:59:59.000Z

    Along with the wide use of pesticides in the world, the concerns over their health impacts are rapidly growing. There is a huge body of evidence on the relation between exposure to pesticides and elevated rate of chronic diseases such as different types of cancers, diabetes, neurodegenerative disorders like Parkinson, Alzheimer, and amyotrophic lateral sclerosis (ALS), birth defects, and reproductive disorders. There is also circumstantial evidence on the association of exposure to pesticides with some other chronic diseases like respiratory problems, particularly asthma and chronic obstructive pulmonary disease (COPD), cardiovascular disease such as atherosclerosis and coronary artery disease, chronic nephropathies, autoimmune diseases like systemic lupus erythematous and rheumatoid arthritis, chronic fatigue syndrome, and aging. The common feature of chronic disorders is a disturbance in cellular homeostasis, which can be induced via pesticides' primary action like perturbation of ion channels, enzymes, receptors, etc., or can as well be mediated via pathways other than the main mechanism. In this review, we present the highlighted evidence on the association of pesticide's exposure with the incidence of chronic diseases and introduce genetic damages, epigenetic modifications, endocrine disruption, mitochondrial dysfunction, oxidative stress, endoplasmic reticulum stress and unfolded protein response (UPR), impairment of ubiquitin proteasome system, and defective autophagy as the effective mechanisms of action. - Highlights: ? There is a link between exposure to pesticides and incidence of chronic diseases. ? Genotoxicity and proteotoxicity are two main involved mechanisms. ? Epigenetic knowledge may help diagnose the relationships. ? Efficient policies on safe use of pesticides should be set up.

  12. Beryllium disease

    SciTech Connect (OSTI)

    Not Available

    1991-12-20T23:59:59.000Z

    After two workers at the nuclear weapons plant at Oak Ridge National Laboratory in Tennessee were diagnosed earlier this year with chronic beryllium disease (CBD), a rare and sometimes fatal scarring of the lungs, the Department of Energy ordered up a 4-year probe. Now, part of that probe has begun - tests conducted by the Oak Ridge Associated Universities' Center for Epidemiological Research measuring beryllium sensitivity in 3,000 people who've been exposed to the metal's dust since Manhattan Project managers opened the Y-12 plant at Oak Ridge in 1943. Currently, 119 Y-12 employees process beryllium, which has a number of industrial uses, including rocket heat shields and nuclear weapon and electrical components. The disease often takes 20 to 25 years to develop, and the stricken employees haven't worked with beryllium for years. There is no cure for CBD, estimated to strike 2% of people exposed to the metal. Anti-inflammatory steroids alleviate such symptoms as a dry cough, weight loss, and fatigue. Like other lung-fibrosis diseases that are linked to lung cancer, some people suspect CBD might cause some lung cancer. While difficult to diagnose, about 900 cases of CBD have been reported since a Beryllium Case Registry was established in 1952. The Department of Energy (DOE) estimates that about 10,000 DOE employees and 800,000 people in private industry have worked with beryllium.

  13. Bullous Lung Disease

    E-Print Network [OSTI]

    Goldberg, Corey; Carey, Kathleen E

    2013-01-01T23:59:59.000Z

    thorascopic surgery. Bullous Lung Disease REFERENCES 1.S, Kaiser LR. Giant bullous lung disease: evaluation,for bullous disease of the lung. Eur J Cardiothorac Surg.

  14. Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    ters in the placebo group, seven in the 2 gm/day group, andsubjects in the placebo group, seven in the 2 gm/day group,

  15. Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    in the 2 gm/day group, and eight in the 4 gm/day group. Twoin the 2 gm/day group, and for eight in the 4 gm/day group.

  16. Hormonal treatment, mild cognitive impairment and Alzheimer's disease Ryan Joanne , Scali Jaqueline , Carriere Isabelle , Ritchie Karen , Ancelin Marie-Laure *

    E-Print Network [OSTI]

    Boyer, Edmond

    lost at menopause would prevent many of the manifestations of aging, including osteoporosis systems implicated in cognition. Recent hormonal replacement therapy trials in non-demented post-menopausal to the widespread use of Hormone Replacement Therapy (HT) after the menopause, but following the recent publication

  17. Assessment of Alzheimer's disease risk with structural and functional magnetic resonance imaging : an arterial spin labeling study

    E-Print Network [OSTI]

    Bangen, Katherine J.

    2010-01-01T23:59:59.000Z

    Framingham Stroke Risk Pro?le (FSRP; D’Agostino, et al. ,1994). The FSRP is a validated scale that was developed torisk burden. The FSRP provides gender-corrected scores based

  18. A learning deficit related to age and b-amyloid plaques in a mouse model of Alzheimer's disease 

    E-Print Network [OSTI]

    Chen, Guiquan; Chen, Karen S; Knox, Jane H; Inglis, Jennifer; Bernard, Andrew; Martin, Stephen J; Justice, Alan; McConlogue, Lisa; Games, Dora; Freedman, Stephen B; Morris, Richard G M

    2000-12-21T23:59:59.000Z

    Mice that overexpress the human mutant amyloid precursor protein (hAPP) show learning deficits, but the apparent lack of a relationship between these deficits and the progressive b-amyloid plaque formation that the hAPP ...

  19. Exploration of the role of gangliosides and cholesterol in the mechanism of ?-amyloid neurotoxicity in Alzheimer's disease 

    E-Print Network [OSTI]

    Yoo, Suk Joon

    2002-01-01T23:59:59.000Z

    to A? toxicity. In this work, we explored the role of gangliosides and cholesterol in the mechanism of A? neurotoxicity in AD. Specifically, we investigated the feasibility that the binding between A? and the cell membrane, which is proposed...

  20. This article examines the possible involvement of nutrients in the pathogenesis, prevention, or management of Alzheimer's disease (AD).

    E-Print Network [OSTI]

    Wurtman, Richard

    -enzymatic processes (e.g., acting as antioxidants). This article first considers the evidence that deficiencies subnormal levels of a characteristic peptide, A-beta 1­42, in cerebrospinal fluid (CSF) and abnormal brain

  1. Supplemental Material to "Identifying Alzheimer's Disease-Related Brain Regions from Multi-Modality Neuroimaging Data using Sparse

    E-Print Network [OSTI]

    Li, Jing

    -Modality Neuroimaging Data using Sparse Composite Linear Discrimination Analysis" I ­ How does the formulation (5) serve

  2. Molecular Bioinformatics for Diseases

    E-Print Network [OSTI]

    Radivojac, Predrag

    . Curr Opin Pediatr, 13: 22 (2001). Leads to sickle cell anemia Manifestation of disease vastly different

  3. Kidney Disease of Diabetes

    E-Print Network [OSTI]

    Baker, Chris I.

    Kidney Disease of Diabetes National Kidney and Urologic Diseases Information Clearinghouse is the final stage of chronic kidney disease (CKD). Diabetes is the most common cause of kidney failure, accounting for nearly 44 percent of new cases.1 Even when diabetes is controlled, the disease can lead to CKD

  4. Role of paraoxonase 1 (PON1) in organophosphate metabolism: Implications in neurodegenerative diseases

    SciTech Connect (OSTI)

    Androutsopoulos, Vasilis P. [Center of Toxicology Science and Research, University of Crete, Heraklion, Crete (Greece)] [Center of Toxicology Science and Research, University of Crete, Heraklion, Crete (Greece); Kanavouras, Konstantinos [Laboratory of Neurological Sciences, University of Crete, Heraklion, Crete (Greece)] [Laboratory of Neurological Sciences, University of Crete, Heraklion, Crete (Greece); Tsatsakis, Aristidis M., E-mail: aris@med.uoc.gr [Center of Toxicology Science and Research, University of Crete, Heraklion, Crete (Greece)

    2011-11-15T23:59:59.000Z

    Organophosphate pesticides are a class of compounds that are widely used in agricultural and rural areas. Paraoxonase 1 (PON1) is a phase-I enzyme that is involved in the hydrolysis of organophosphate esters. Environmental poisoning by organophosphate compounds has been the main driving force of previous research on PON1 enzymes. Recent discoveries in animal models have revealed the important role of the enzyme in lipid metabolism. However although PON1 function is well established in experimental models, the contribution of PON1 in neurodegenerative diseases remains unclear. In this minireview we summarize the involvement of PON1 genotypes in the occurrence of Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis. A brief overview of latest epidemiological studies, regarding the two most important PON1 coding region polymorphisms PON1-L55M and PON1-Q192R is presented. Positive and negative associations of PON1 with disease occurrence are reported. Notably the MM and RR alleles contribute a risk enhancing effect for the development of some neurodegenerative diseases, which may be explained by the reduced lipoprotein free radical scavenging activity that may give rise to neuronal damage, through distinct mechanism. Conflicting findings that fail to support this postulate may represent the human population ethnic heterogeneity, different sample size and environmental parameters affecting PON1 status. We conclude that further epidemiological studies are required in order to address the exact contribution of PON1 genome in combination with organophosphate exposure in populations with neurodegenerative diseases.

  5. Amyloid Deposits: Protection Against Toxic Protein Species?

    E-Print Network [OSTI]

    Lindquist, Susan

    Neurodegenerative diseases ranging from Alzheimer’s disease and polyglutamine diseases to transmissible spongiform encephalopathies are associated with the aggregation and accumulation of misfolded proteins. In several ...

  6. Interim Chronic Beryllium Disease

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-12-08T23:59:59.000Z

    Establishes Departmental expectations for addressing chronic beryllium disease throughout the Department until a Departmental rule on beryllium is promulgated. This Notice was replaced by final rule 10 CFR Part 850, Chronic Beryllium Disease Prevention Program, published December 8, 1999.

  7. Cardiovascular Disease (CVD) Coronary heart disease

    E-Print Network [OSTI]

    Dever, Jennifer A.

    have a greater prevalence in women · Osteoporosis · Autoimmune disease A. Osteoporosis · Osteoporosis ­ disorder of low bone mass, microarchitectural denegra7on% of all women >65 years old have osteoporosis (15% of all Caucasian women

  8. PSU University Housing ADA Accommodation Request Form

    E-Print Network [OSTI]

    Bertini, Robert L.

    , Suite 210 Portland, OR 97211 Fax (503) 725-4394 * Phone (503) 725-4333 OFFICE USE ONLY Date received

  9. ADA REGIONAL PROJECT COORDINATORS (December 2013)

    E-Print Network [OSTI]

    Walter, M.Todd

    Group (718) 482 - 4016 Mark.Maglienti@dot.ny.gov MAIN OFFICE - ALBANY Vanessa Saari Policy and Planning (518) 457 - 0637 Vanessa.Saari@dot.ny.gov #12;

  10. ADA ES Inc | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnualProperty Edit withTianlinPapersWindey Wind6:00-06:00 U.S.ratios in CenozoicACALADA ES Inc Jump

  11. Ada, Ohio: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to:Ezfeedflag JumpID-fTriWildcat 1AMEE Jump to:Ohio: Energy Resources Jump to: navigation, search

  12. The 2006 Harvard / Paul F. Glenn Symposium on Aging

    E-Print Network [OSTI]

    Church, George M.

    diseases of aging, such as diabetes, cancer, Alzheimer's and heart disease. A recent study1 concluded

  13. Published: December 30, 2010 r 2010 American Chemical Society 301 dx.doi.org/10.1021/cb1001729 |ACS Chem. Biol. 2011, 6, 301307

    E-Print Network [OSTI]

    Weiss, Gregory A.

    of diseases including Alzheimer's disease, muscular dystrophy, cancer, diabetes, obesity, and asthma,6

  14. IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS 1 High Specificity Binding of Lectins to

    E-Print Network [OSTI]

    Dagenais, Mario

    that affect mankind, including cancer, diabetes, heart diseases, infectious diseases, flu, Alzheimer

  15. June 17, 2013 Symposium on Aging

    E-Print Network [OSTI]

    Church, George M.

    to forestall and treat diseases of aging such as diabetes, cancer, Alzheimer's and heart disease. Today

  16. Adventures in Infectious Diseases

    ScienceCinema (OSTI)

    Fisher-Hoch, Susan [University of Texas School of Public Health

    2014-06-25T23:59:59.000Z

    Dr. Susan Fisher-Hoch, Virologist and Epidemiologist, will discuss her research and travels associated with viral hemorrhagic fevers. From the Ebola outbreak in Reston, Virginia to outbreaks of Crimean Congo Hemorrhagic Fever in South Africa, Senegal, and Saudi Arabia, Dr. Fisher-Hoch has studied and tracked the pathophysiology of these viral diseases. These studies have led her from the Center for Disease Control in the United States, to Lyon, France where she was instrumental in designing, constructing, and rendering operational a laboratory capable of containing some of the world's most dangerous diseases.

  17. Chronic Conditions and Disease Prevention

    E-Print Network [OSTI]

    , diabetes, heart disease and osteoarthritis. One-on-One Nutrition Counseling Help with weight management and supportive program for those who have chronic diseases such as diabetes, heart disease, stroke, arthritis

  18. Large scale disease prediction

    E-Print Network [OSTI]

    Schmid, Patrick R. (Patrick Raphael)

    2008-01-01T23:59:59.000Z

    The objective of this thesis is to present the foundation of an automated large-scale disease prediction system. Unlike previous work that has typically focused on a small self-contained dataset, we explore the possibility ...

  19. Health & Medicine Heart Disease

    E-Print Network [OSTI]

    Rogers, John A.

    See Also: Health & Medicine Heart Disease· Medical Imaging· Vioxx· Matter & Energy Electronics· Technology· Medical Technology· Reference Artificial heart· Biosensor· Circuit design· Machine· Science and stretchable electronics can map waves of electrical activity in the heart with better resolution and speed

  20. Periodontal Disease and Heart Health

    E-Print Network [OSTI]

    Goldman, Steven A.

    Periodontal Disease and Heart Health Deaf HealthTalks Presenter: Christopher Lehfeldt, DDS Elmwood #12;X-ray showing bone loss rickwilsondmd.typepad.com Thursday, March 15, 12 #12;5. What is heart disease? · The medical name for heart disease is cardiovascular disease (CVD) · An American dies from CVD

  1. Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Abeta/amyloid burden in a transgenic mouse model of Alzheimer's disease

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    correlation of Ab with TGFb and SDF-1. Immunized males showlevels of MCP-1, IL-10, SDF-1, and RANTES in PBS-treatedT, Gawaz M: Decreased CXCL12 (SDF-1) plasma levels in early

  2. Inhibition of Amyloid-? (A?) Peptide-Binding Alcohol Dehydrogenase-A? Interaction Reduces A? Accumulation and Improves Mitochondrial Function in a Mouse Model of Alzheimer's Disease

    E-Print Network [OSTI]

    Yao, Jun; Du, Heng; Yan, Shiqiang; Fang, Fang; Wang, Chaodong; Lue, Lih-Fen; Guo, Lan; Chen, Doris; Stern, David M.; Moore, Frank J. Gunn; Chen, John Xi; Arancio, Ottavio; Yan, Shirley ShiDu

    2011-02-09T23:59:59.000Z

    that inhibition of the ABAD-A? interaction, using a decoy peptide (DP) in vitro and in vivo, protects against aberrant mitochondrial and neuronal function and improves spatial learning/memory. Intraperitoneal administration of ABAD-DP [fused to the transduction...

  3. Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    University, Canberra, ACT, Australia. Correspondence: Dr M131 Garran Road, Canberra, ACT 0200, Australia. E-mail:

  4. Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    46: 561--584. 7 Efron B. Bootstrap methods: another look atof the number of bootstrap samples. J Stat Plann Inferencemp ORIGINAL ARTICLE Pooling/bootstrap-based GWAS (pbGWAS)

  5. Mapping Ventricular Expansion and its Clinical Correlates in Alzheimer's Disease and Mild Cognitive Impairment using Multi-Atlas Fluid Image Alignment

    E-Print Network [OSTI]

    Thompson, Paul

    Impairment using Multi-Atlas Fluid Image Alignment Yi-Yu Chou1 , Natasha Leporé1 , Christina Avedissian1 , Sarah K. Madsen1 , Xue Hua1 , Clifford R. Jack, Jr. 2 , Michael W. Weiner3 , Arthur W. Toga1 , Paul M

  6. Reproductive Diseases in Cattle

    E-Print Network [OSTI]

    Sprott, L. R.; Field, Bob

    1998-12-03T23:59:59.000Z

    susceptible. Droplets of urine from infected cows can infect normal cows after contact with the eye or mucous membranes of the nose or mouth. The disease infects more cattle each day, preventing cows from settling and lengthening their calving intervals... abortus) fetal membranes from aborting heifers at 4-12 not vaccinate bulls. cow; fetus; months. placenta Leptospirosis Bacterial (At least Urine of infected Any stage, Sample 10 Every 6 months Laboratory should deter- 5 serotypes) animals...

  7. Inherited risk for common disease

    E-Print Network [OSTI]

    Banava, Helen

    2007-01-01T23:59:59.000Z

    Linkage disequilibrium studies have discovered few gene-disease associations for common diseases. The explanation has been offered that complex modes of inheritance govern risk for cancers, cardiovascular and cerebrovascular ...

  8. EA-0896: Final Environmental Assessment

    Broader source: Energy.gov [DOE]

    Center for Nuclear Medicine Research in Alzheimer's Disease Health Sciences Center- West Virginia University

  9. EA-0896: Finding of No Significant Impact

    Broader source: Energy.gov [DOE]

    Center for Nuclear Medicine Research in Alzheimer's Disease Health Sciences Center- West Virginia University

  10. Development of Graves' disease following radiation therapy in Hodgkin's disease

    SciTech Connect (OSTI)

    Loeffler, J.S.; Tarbell, N.J.; Garber, J.R.; Mauch, P.

    1988-01-01T23:59:59.000Z

    Radiation-related thyroid dysfunction is a common occurrence in patients with Hodgkin's disease treated with mantle field radiation. Although chemical and clinical hypothyroidism are most commonly seen, Graves' disease has also been described. We have examined the records of 437 surgically staged patients who received mantle field irradiation between April 1969 and December 1980 to ascertain the frequency of manifestations of Graves' disease. Within this group, seven patients developed hyperthyroidism accompanied by ophthalmic findings typical of those seen in Graves' disease. The actuarial risk of developing Graves' disease at 10 years following mantle irradiation for Hodgkin's disease was 3.3% in female patients and 1% in male patients in this study. The observed/expected ratios were 5.9 and 5.1 for female and male patients, respectively. This observed risk significantly exceeded that seen in the general population.

  11. Genomic mosaicism in the human brain

    E-Print Network [OSTI]

    Westra, Jurjen Willem

    2008-01-01T23:59:59.000Z

    Zlokovic BV (2008) The blood-brain barrier in health andmosaicism in the human brain ………………………………………. Chapter Threethe Alzheimer’s disease brain ………………………………. Chapter Five DNA

  12. A Manual of Poultry Diseases.

    E-Print Network [OSTI]

    Bell, R. R.; Flowers, A. I.; Grumbles, L. C.; Meinecke, C. F.; Patterson, C. M.; Wormell, B. C.; Hall, C. F.

    1965-01-01T23:59:59.000Z

    " of ocular leucosis is specific. Hatchery and Breeder Flock Health Management Sanitation is a much used, but poorly defined word. The usual implication is that sanitation is a universally understood practice that may be applied to prevent all diseases... must be based on the nature of specific diseases. The ;kmbiguity surrounding the term "sanitation" can be avoided by using a term "management and sanitation for disease prevention." This phrase then would be defined as all practices, specific...

  13. Using Wikipedia to forecast diseases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    said. "In the same way we check the weather each morning, individuals and public health officials can monitor disease incidence and plan for the future based on today's...

  14. Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence

    E-Print Network [OSTI]

    Brinton, Roberta Diaz

    Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive Bioenergetics Reproductive senescence Alzheimer's disease Estrogen Background: We have previously demonstrated that mitochondrial bioenergetic deficits precede Alzheimer's pathology in the female triple transgenic Alzheimer's (3

  15. MFR PAPER 1300 Shellfish Diseases

    E-Print Network [OSTI]

    promise for the efficient recycling of organic waste materials, such as agricultural wastes, and metazoan parasitic and infectious agents. In addition, predators, toxic agents, and fouling organisms studied. DISEASES OF SHELLFISH A list of organisms that cause com- mon diseases in oysters is shown

  16. Early detection of contagious diseases

    DOE Patents [OSTI]

    Colston, Jr., Billy W. (San Ramon, CA); Milanovich, Fred P. (Lafayette, CA); Estacio, Pedro (Mission San Jose, CA); Chang, John (Walnut Creek, CA)

    2011-08-09T23:59:59.000Z

    This invention provides an electronic proximity apparatus and a surveillance method using such an apparatus for alerting individuals that are exposed to a contagious disease. When a person becomes symptomatic and is diagnosed as positive for a given contagious agent, individuals that have recently maintained a threshold proximity with respect to an infected individual are notified and advised to seek immediate medial care. Treatment of individuals in the very early phases of infection (pre-symptomatic) significantly reduces contagiousness of the infected population first exposed to the contagious disease, thus preventing spread of the disease throughout the general population.

  17. Lessons from a rare disease

    E-Print Network [OSTI]

    Dutchen, Stephanie Lynn

    2009-01-01T23:59:59.000Z

    Progeria is a genetic aging disease of childhood affecting an estimated one in four to eight million births. Children with progeria experience a range of developmental disorders and aging-like symptoms, including wrinkled ...

  18. A Manual of Poultry Diseases.

    E-Print Network [OSTI]

    Hall, C. F.; Bell, R. R.; Clifford, R. L., Jr.; Glass, S. E.; Grimes, J. E.; Grumbles, L. C.; Keahey, E. E.; Wormell, B. C.

    1971-01-01T23:59:59.000Z

    surrounding the term "sanitation" can be avoided by using the expression "management and sanitation for disease preven- , tion." This phrase then would be defined as all practices, specific and nonspecific, that the poultry- man applies to ptevent.... Change litter and thoroughly clean and disinfect the house and equipment between each group of birds. While litter selection and management is a large subject, applying this recommendation as a general practice will prevent many disease and parasite...

  19. A Century of Progress: Milestones in Sickle Cell Disease

    E-Print Network [OSTI]

    Bandettini, Peter A.

    Disease? Sickle cell disease, also known as sickle cell anemia, is inherited. People who have the disease

  20. Imaging Lung Disease in Systemic Sclerosis

    E-Print Network [OSTI]

    Strollo, Diane; Goldin, Jonathan

    2010-01-01T23:59:59.000Z

    W, et al. : Interstitial lung disease in progressiveGL, Myers JL: Diffuse lung disease: diagnostic accuracy ofsurgical biopsy of the lung. Radiology 1997, 205:229–234.

  1. Heart Disease and Early Heart Attack Care

    E-Print Network [OSTI]

    Ohta, Shigemi

    Heart Disease and Early Heart Attack Care Pamela Kostic, RN, CCCC, Chest Pain Coordinator, Stony Risk Factors · EHAC & Prevention #12;Heart disease includes a number of problems affecting the heart and the blood vessels in the heart. #12;Types of heart disease include: · Coronary artery disease (CAD) · Angina

  2. Radiologic atlas of rheumatic diseases

    SciTech Connect (OSTI)

    Dihlmann, W.

    1986-01-01T23:59:59.000Z

    This book is an ''atlas of rheumatic joint disease'' selected from 20 years of personal experience by the author. The author sets a goal of demonstrating the value of soft-tissue imaging in the diagnosis of early joint disease. This goal is achieved with high quality reproductions, many of which are presented in duplicate to illustrate bone and soft-tissue changes. The contents include an introductory overview of the ''Mosaic of Arthritis'' followed by sections on adult rheumatoid arthritis, seronegative spondyloarthropathies, classic collagen disease, enthesiopathies, and lastly a section on gout and psuedogout. The subject index is specific and indexes figures with boldface type. Each section is introduced by a brief outline or overview of the radiographic spectrum of the joint disorder to be illustrated.

  3. Asset Management for ADA Compliance Using Advanced Technologies

    E-Print Network [OSTI]

    Bertini, Robert L.

    , the standard for what constitutes acceptable practice (and, by extension, what could become a best practice Side Flare #12;#12;Field Documentation Equipped with a digital camera, graphic interface, & data entry

  4. ada releases updated: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Buffalo Foundation. 1983 Research Assistant to Expedition. PROFESSIONAL SOCIETIES and REVIEW BOARDS Professional Societal Affiliations (member) American Association Hood, Craig...

  5. adenosine deaminase ada: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    James A Zwiebel; Eli Gilboa; R Michael Blaese; Arthur Nienhuis; Richard J O& apos; reilly; W. French Anderson 1987-01-01 7 A Role for Adenosine Deaminase in Drosophila Larval...

  6. Modularization of the DADAISM Ada Database System Architecture

    E-Print Network [OSTI]

    Keller, Arthur M.

    the modularization of a new data- base management system architecture. This DBMS is not intended to be viewed 22, 1986 at Beijing, China. of modulespeci cations for a DBMS, which can be used to support any implemen- tation paradigm is necessary to handle the evolution of database systems over the next few

  7. Modularization of the DADAISM Ada Database System Architecture

    E-Print Network [OSTI]

    Keller, Arthur M.

    the modularization of a new data­ base management system architecture. This DBMS is not intended to be viewed--22, 1986 at Beijing, China. of module specifications for a DBMS, which can be used to support any of those implemen­ tation paradigm is necessary to handle the evolution of database systems over the next few

  8. MONITORING AN ADA SOFTWARE DEVELOPMEN T Victor R. Basili

    E-Print Network [OSTI]

    Basili, Victor R.

    and Elizabeth Kruesi are now with Software Metrics, Inc. Sylvia Sheppard is with Booz, Allen, and Hamilton, Inc

  9. ADA Requirements for Workplace Charging Installation | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy China 2015ofDepartmentDepartment of Energy-Chapter 7.1 (May 2012) 2PolicyThe Americans

  10. Venkatraman Ramakrishnan, Thomas A. Steitz, Ada E. Yonath, and Ribosome

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del SolStrengthening aTurbulenceUtilize Available ResourcesVehicleMayo 2010

  11. ADA Requirements for Workplace Charging Installation | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The Future of1 A Strategic Framework for SMRA ViewNo.PLANNING REFERENCESADA

  12. with Disabilities Act Requirements Workplace ADA Requirements for Workplace

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed off Energy.gov. Are you sure you want toworldPower 2010 1 T he utility world hasDate RecComplying

  13. Easy Gardening.....Disease Control 

    E-Print Network [OSTI]

    Johnson, Jerral; Johnson, Jerral

    2009-05-29T23:59:59.000Z

    on plant roots and cause stunted plants. The most damaging nematode in the home garden is root knot. It causes galls or knots on susceptible plants such as toma- A good home gardener recognizes the symptoms of plant diseases quickly and takes steps...

  14. Environmental Contributions to Allergic Disease

    E-Print Network [OSTI]

    Levetin, Estelle

    with increased exposure to air pollution and indoor contaminants such as house dust mites, cockroaches linked to the severity of allergic disease. The contribution of house dust mites, cockroaches, animal some of the strongest evidence sug- gests a compelling link between exposure to passive smoking

  15. MENINGOCOCCAL DISEASE WHAT YOU NEED TO KNOW

    E-Print Network [OSTI]

    Missouri-Rolla, University of

    , coughing and having close social contact (living in the same household) are examples of how this disease

  16. Are You at Risk for Heart Disease?

    E-Print Network [OSTI]

    Bandettini, Peter A.

    Are You at Risk for Heart Disease? Healthy Heart, Healthy Family Nangangamba Ka Bang Magkaroon ng Are You at Risk for Heart Disease? Healthy Heart, Healthy Family Nangangamba Ka Bang Magkaroon ng Sakit sa Puso? Malusog na Puso, Malusog na Pamilya #12;Did you know that heart disease is a serious problem

  17. Coronary Heart Disease, Hypertension, Stroke, and

    E-Print Network [OSTI]

    Meagher, Mary

    Coronary Heart Disease, Hypertension, Stroke, and Diabetes #12;Coronary Heart Disease: Overview by atherosclerosis ­ Narrowing of coronary arteries, the vessels that supply the heart · Disease process: coronary and arms Myocardial infarction - heart attack, ischemia - local blood supply decreased resulting in cell

  18. Clioquinol promotes the degradation of metal-dependent amyloid-?  (A?) oligomers to restore endocytosis and ameliorate A?  toxicity

    E-Print Network [OSTI]

    Lindquist, Susan

    Alzheimer’s disease (AD) is a common, progressive neurodegenerative disorder without effective disease-modifying therapies. The accumulation of amyloid-? peptide (A?) is associated with AD. However, identifying new compounds ...

  19. Controlling Diseases on Ornamental Plants.

    E-Print Network [OSTI]

    Horne, C. Wendell; Johnson, Jerral D.; Walla, Walter J.

    1979-01-01T23:59:59.000Z

    powder is used as a spray to control powdery mildew and foliage diseases. It is available as Daconil 2787?, Bravo? and Ferti-Iome Broad Spectrum Liquid Fungicide?. Formaldehyde: This is a 37 percent solution in water and methanol which is used... and move it over the loosened soil. Drain tile or iron pipe buried in the soil helps to distribute the ste~m. Heat the soil until a medium-sized potato buried several inches deep is cooked thoroughly. Use formaldehyde as manufacturer directs. Water...

  20. Diseases of Peaches and Plums.

    E-Print Network [OSTI]

    Johnson, Jerral D.

    1980-01-01T23:59:59.000Z

    Uetial ' . " ~. -~c _ '1-" ,," 'J .~. ," .. " Each year diseases destroy a large portion of the potential fruit crop in Texas. This loss begins in the orchard and continues until the fruit is con sumed. Complete lack of production on improperly sprayed trees... enough pressure to break through the bark and flow down the outside of a tree limb. Cankers will have a sour smell similar to that fol lowing a freeze. Although leaf spotting has been reported, it does not always occur. In Texas, leaf spotting has...

  1. The 2008 Harvard / Paul F. Glenn Symposium on Aging

    E-Print Network [OSTI]

    Church, George M.

    of aging such as diabetes, cancer, Alzheimer's and heart disease. Thus, a major goal in the coming years

  2. The 2009 Harvard / Paul F. Glenn Symposium on Aging

    E-Print Network [OSTI]

    Church, George M.

    of aging such as diabetes, cancer, Alzheimer's and heart disease. Thus, a major goal in the coming years

  3. Characterization of Lung's Emphysema Distribution: Numerical Assessment of Disease Development

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Characterization of Lung's Emphysema Distribution: Numerical Assessment of Disease Development M, Egypt. Abstract--Chronic Obstructive Pulmonary Disease (COPD) refers to a group of lung diseases bronchitis. Pulmonary emphysema is defined as a lung disease characterized by "abnormal enlargement

  4. Blood Sugar and Brothers' Voices: An Exploratory Study Of The Self-Care Management Experiences of African-American Men Living With Type 2 Diabetes

    E-Print Network [OSTI]

    Sherman, Ledric D

    2013-07-23T23:59:59.000Z

    - dependent diabetes, is the most common form of diabetes (ADA, 2011). xi TABLE OF CONTENTS Page ABSTRACT .............................................................................................................. ii...-Americans, Native Hawaiians, and other Pacific Islanders (ADA, 2011). Epidemiology of Type 2 Diabetes According the 2010 Center for Disease Control and Prevention estimated figures, 25.8 million people in the United States aged 20 years and older are affected...

  5. Imaging Lung Disease in Systemic Sclerosis

    E-Print Network [OSTI]

    Strollo, Diane; Goldin, Jonathan

    2010-01-01T23:59:59.000Z

    undergoing surgical biopsy of the lung. Radiology 1997, 205:disease. In Pathology of the Lung. Edited by Thurlbeck WM,organs, most frequently the lungs and gastrointes- tinal

  6. Enzyme replacement therapy for Pompe disease

    E-Print Network [OSTI]

    Burris, Ryan Jonathan William

    2010-01-01T23:59:59.000Z

    CALIFORNIA, SAN DIEGO Enzyme Replacement Therapy for Pompe3 1.3 Enzyme Replacement Therapy for Pompe Disease…………………… 5Receptor ERT – Enzyme Replacement Therapy LSD – Lysosomal

  7. Mathematical Model Applications to Disease and Homeland ...

    E-Print Network [OSTI]

    Mathematical Model Applications to Disease and Homeland Security The events of ... but have no data or reliable information that would help in the planning or ...

  8. Fracture, aging and disease in bone

    E-Print Network [OSTI]

    Ager, J.W.; Balooch, G.; Ritchie, R.O.

    2006-01-01T23:59:59.000Z

    on glucocorticoid-induced osteoporosis. Rheumatic DiseaseGlucocorticoid-induced osteoporosis. Endocrinol Metab. Clin.of cortico-steroid osteoporosis. A meta-analysis. Osteoporos

  9. Undifferentiated Connective Tissue Disease-Associated Interstitial Lung Disease: Changes in Lung Function

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    Lung (2010) 188:143–149 DOI 10.1007/s00408-009-Tissue Disease-Associated Interstitial Lung Disease:Changes in Lung Function Brent W. Kinder • Cyrus Shariat •

  10. COMMON DISEASES OF FUR BEARING ANIMALS II. DISEASES OF CHINCHILLAS, NUTRIA, AND RABBITS*

    E-Print Network [OSTI]

    COMMON DISEASES OF FUR BEARING ANIMALS II. DISEASES OF CHINCHILLAS, NUTRIA, AND RABBITS* T. J. Pridhamt, Joan Buddt, and L. H. A. Karstadt DISEASES OF THE CHINCHILLA BACTERIAL INFECTIONS and errors in management are the most common causes of death in the chinchillas submitted to this laboratory. LISTERIOSIS

  11. Coronary Heart Disease, Hypertension, Stroke, and

    E-Print Network [OSTI]

    Meagher, Mary

    Coronary Heart Disease, Hypertension, Stroke, and Diabetes #12;Coronary Heart Disease: Overview to illnesses caused by atherosclerosis ­ Narrowing of coronary arteries, the vessels that supply the heart that radiates across the chest and arms Ø Myocardial infarction - heart attack, ischemia - local blood supply

  12. X-ray atlas of rheumatic diseases

    SciTech Connect (OSTI)

    Dihlmann, W.

    1986-01-01T23:59:59.000Z

    This atlas comprises instructive X-rays of the various inflammatory rheumatic joint diseases in all stages at the extremities and the spinal column. In addition, the complex pattern of the wide range of arthroses, also known as degenerative rheumatic disease is included. Besides the instructive pointers to X-ray diagnosis, the book is also a guide to differential diagnosis. Hence, this book is actually an X-ray atlas of joint diseases in general. Selected Contents: Introduction: What Does ''Rheumatism'' Actually Mean./Radiographic Methodology in Rheumatic Diseases of the Locomotor System/The Mosaic of Arthritis/Adult Rheumatoid Arthritis/Seronegative Spondylarthritis/Classic Collagen Diseases/Enthesiopathies/Gout-Pseudogout

  13. Study of collagen structure in canine myxomatous mitral valve disease 

    E-Print Network [OSTI]

    Hadian, Mojtaba

    2009-01-01T23:59:59.000Z

    Myxomatous mitral valve disease (MMVD) is the single most common acquired cardiac disease of dogs, and is a disease of significant veterinary importance. It also bears close similarities to mitral valve prolapse in humans ...

  14. Behavioral impulsivity and hallucinations : insights from Parkinson's disease

    E-Print Network [OSTI]

    Ashourian, Paymon

    2011-01-01T23:59:59.000Z

    Parkinson's disease (PD) is an age-related degenerative disease of the brain, characterized by motor, cognitive, and psychiatric symptoms. Neurologists and neuroscientists now understand that several symptoms of the disease, ...

  15. Chemicals for Plant Disease Control at Home

    E-Print Network [OSTI]

    Ong, Kevin

    2007-10-30T23:59:59.000Z

    common chemical names and the corresponding chemical name for each active ingredient. Kevin Ong* ?Assistant Professor and Extension Plant Pathologist, The Texas A&M University System Table 1. Plant disease control chemicals. Common name Chemical name 1...

  16. HLB in Argentina: a New Disease Outbreak

    E-Print Network [OSTI]

    2014-01-01T23:59:59.000Z

    Vol. 1 (2014) HLB in Argentina: a New Disease Outbreak Outi,E. 6 SENASA, Bs. As. Argentina MAGyP Bs. As INTA Montecarlo,Paraná, 300 km away from Argentina’s Northeastern border. In

  17. acid biomarker detection: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Websites Summary: .g., cancer, Alzheimer's disease) by positron emission tomography (PET).3 In a similar vein, we have developedDisease Detection by Ultrasensitive...

  18. antioxidant metabolism leading: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    end into a range of disorders such as Alzheimers disease, Parkinsons disease, aging and many other neural disorders. Toxicity of free radicals contributes to proteins and...

  19. Tracking Living Cells as They Differentiate in Real Time

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    these projects will target Alzheimer's disease, macular degeneration of the retina in diabetes, and mitochondrial diseases in children. In addition, specific processes like protein...

  20. Restoration of Endangered White Abalone, Haliotis sorenseni: Resource Assessment, Genetics, Disease and Culture of Captive Abalone

    E-Print Network [OSTI]

    Burton, Ronald S.; McCormick, Thomas B.; Moore, James D.; Friedman, Carolyn S.

    2008-01-01T23:59:59.000Z

    Haliotis sorenseni: Resource Assessment, Genetics, Disease,Haliotis sorenseni: Resource Assessment, Genetics, Disease,Haliotis sorenseni: Resource Assessment, Genetics, Disease,

  1. adult celiac disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Websites Summary: with a dietitian or physician who specializes in celiac disease. People with celiac disease should always read food for Celiac Awareness; Cynthia Kupper,...

  2. arthritis disease activity: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    systemic, inflammatory disease causing disability. Identifying factors that influence the impact of the disease is important for planning adequate (more) Kuhlow, Heide 2007-01-01...

  3. ASSISTANT/ASSOCIATE/FULL PROFESSOR Diabetes, Obesity, Metabolic Disease

    E-Print Network [OSTI]

    Cinabro, David

    ASSISTANT/ASSOCIATE/FULL PROFESSOR Diabetes, Obesity, Metabolic Disease Department strengths in diabetes, obesity and metabolic disease. Outstanding candidates with expertise

  4. Integrated Molecular Signature of Disease: Analysis of Influenza...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of Disease: Analysis of Influenza Virus-Infected Macaques through Functional Genomics and Integrated Molecular Signature of Disease: Analysis of Influenza Virus-Infected...

  5. Structural genomics of infectious disease drug targets: the SSGCID...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of infectious disease drug targets: the SSGCID. Structural genomics of infectious disease drug targets: the SSGCID. Abstract: The NIAID-funded SSGCID is a consortium established to...

  6. The Seattle Structure Genomics Center for Infectious Disease...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The Seattle Structure Genomics Center for Infectious Disease (SSGCID). The Seattle Structure Genomics Center for Infectious Disease (SSGCID). Abstract: The NIAID-funded Seattle...

  7. anthracnose disease control: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    disease of papaya Babak Madani a,*, Mahmud Tengku Muda Mohamed a,**, Alan R. Biggs c , Jugah Kadir October 2013 Keywords: Papaya Anthracnose Calcium Disease incidence...

  8. anthracnose disease caused: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    disease of papaya Babak Madani a,*, Mahmud Tengku Muda Mohamed a,**, Alan R. Biggs c , Jugah Kadir October 2013 Keywords: Papaya Anthracnose Calcium Disease incidence...

  9. A Systems Biology Approach to Infectious Disease Research: Innovating...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm. A Systems Biology Approach to Infectious Disease Research: Innovating the...

  10. Vascular pathology in the aged human brain

    E-Print Network [OSTI]

    Grinberg, Lea Tenenholz; Thal, Dietmar Rudolf

    2010-01-01T23:59:59.000Z

    vascular pathology, and the AD brain. Neurology 65: 259–265brospinal ?uid from the rat brain. Acta Neuropathol (Berl)and Alzheimer’s disease in the brains of elderly individuals

  11. Nanofluidic biosensing for beta-amyloid detection 

    E-Print Network [OSTI]

    Chou, I-Hsien

    2009-05-15T23:59:59.000Z

    A nanofluidic biosensor using surface-enhanced Raman scattering (SERS) was developed to detect the ?-amyloid (A?) protein, one of the biomarkers of Alzheimer’s disease (AD). Recent studies have indicated that investigating changes in relative...

  12. Nanofluidic biosensing for beta-amyloid detection

    E-Print Network [OSTI]

    Chou, I-Hsien

    2009-05-15T23:59:59.000Z

    A nanofluidic biosensor using surface-enhanced Raman scattering (SERS) was developed to detect the ?-amyloid (A?) protein, one of the biomarkers of Alzheimer’s disease (AD). Recent studies have indicated that investigating changes in relative...

  13. Free membership Agriculture Alzheimer Astronomy

    E-Print Network [OSTI]

    Espinosa, Horacio D.

    Technology Vaccines Water prostate cancer New Nanodiamond Tool for Next-Generation Cancer Treatments be used both as a research tool in the development of next-generation cancer treatments Biochemistry Biology Blood Brain Breast Cancer Cancer Cardiology Cell Biology Cells Chemistry Climate DNA

  14. Chronic beryllium disease: Diagnosis and management

    SciTech Connect (OSTI)

    Rossman, M.D. [Hospital of the Univ. of Pennsylvania, Philadelphia, PA (United States)

    1996-10-01T23:59:59.000Z

    Chronic beryllium disease is predominantly a pulmonary granulomatosis that was originally described in 1946. Symptoms usually include dyspnea and cough. Fever, anorexia, and weight loss are common. Skin lesions are the most common extrathoracic manifestation. Granulomatous hepatitis, hypercalcemia, and kidney stones can also occur. Radiographic and physiologic abnormalities are similar to those in sarcoidosis. While traditionally the pathologic changes included granulomas and cellular interstitial changes, the hallmark of the disease today is the well-formed granuloma. Immunologic studies have demonstrated a cell-mediated response to beryllium that is due to an accumulation of CD4{sup +} T cells at the site of disease activity. Diagnosis depends on the demonstration of pathologic changes (i.e., granuloma) and evidence that the granuloma was caused by a hypersensitivity to beryllium (i.e., positive lung proliferative response to beryllium). Using these criteria, the diagnosis of chronic beryllium disease can now be made before the onset of clinical symptoms. Whether, with early diagnosis, the natural course of this condition will be the same as when it was traditionally diagnosed is not known. Currently, corticosteroids are used to treat patients with significant symptoms or evidence of progressive disease. 21 refs.

  15. Transgenic Mouse Model of Chronic Beryllium Disease

    SciTech Connect (OSTI)

    Gordon, Terry

    2009-05-26T23:59:59.000Z

    Animal models provide powerful tools for dissecting dose-response relationships and pathogenic mechanisms and for testing new treatment paradigms. Mechanistic research on beryllium exposure-disease relationships is severely limited by a general inability to develop a sufficient chronic beryllium disease animal model. Discovery of the Human Leukocyte Antigen (HLA) - DPB1Glu69 genetic susceptibility component of chronic beryllium disease permitted the addition of this human beryllium antigen presentation molecule to an animal genome which may permit development of a better animal model for chronic beryllium disease. Using FVB/N inbred mice, Drs. Rubin and Zhu, successfully produced three strains of HLA-DPB1 Glu 69 transgenic mice. Each mouse strain contains a haplotype of the HLA-DPB1 Glu 69 gene that confers a different magnitude of odds ratio (OR) of risk for chronic beryllium disease: HLA-DPB1*0401 (OR = 0.2), HLA-DPB1*0201 (OR = 15), HLA-DPB1*1701 (OR = 240). In addition, Drs. Rubin and Zhu developed transgenic mice with the human CD4 gene to permit better transmission of signals between T cells and antigen presenting cells. This project has maintained the colonies of these transgenic mice and tested the functionality of the human transgenes.

  16. Thomas E. Hinds Although many diseases attack aspen, relatively few

    E-Print Network [OSTI]

    DISEASES Thomas E. Hinds Although many diseases attack aspen, relatively few kill or seriously of aspen, whereas there are subtle differ- ences in distribution between the important decay fungi. Foliage Diseases Fungus Diseases Many fungi are capable of attacking aspen leaves, from juvenile growth

  17. ATP Release and Signaling via P2Y Receptors Regulate Cardiac Fibroblast Phenotype and Activity

    E-Print Network [OSTI]

    Lu, David

    ADA PSB 603 P2 (P2Y 2 ) Cx(43,45) ATP collagen ?-SMA PAI-1from ventricular CFs in vitro via Cx hemi-channels and thatCVD cardiovascular disease Cx connexin DAG diacyl glycerol

  18. Huntington's disease: underlying molecular mechanisms and emerging

    E-Print Network [OSTI]

    Morimoto, Richard

    transcriptional mechanism also dictates the expression of polygluta- mine proteins. Here, we summarize the key with no disease modifying treatments available [1]. At the molecular level, HD is caused by a CAG trinu- cleotide is composed of proteins involved in transcription, DNA maintenance, cell cycle regulation, cellular orga

  19. News you can use Disease management

    E-Print Network [OSTI]

    Isaacs, Rufus

    DISEASE MANAGEMENT PAGE 9 CALENDAR A u g u s t 2 5 , 2 0 1 0 V O L 1 , I S S U E 1 5 A Michigan State. Elm Valley Road in Suttons Bay. Speaker: Rufus Isaacs will discuss late-season insect management. More

  20. Major Oak Diseases and Their Control.

    E-Print Network [OSTI]

    Johnson, Jerral D.; Appel, David N.

    1984-01-01T23:59:59.000Z

    Station, Texas (Blaok Page bl-?OriglulBidletial? / . , ,;..,' ,- ; ~ ~ " trees of Texas and are also... important components of forests and rangelands. They are normally long-lived, possess the ability to withstand adverse weather and have been considered disease resistant. During the drought in the mid 1950s large expanses of oak trees began dying...

  1. Osteoporosis Osteoporosis is a disease character-

    E-Print Network [OSTI]

    SS-167-R05 Osteoporosis Osteoporosis is a disease character- ized by structural deterioration of bone tissue, leading to fragile bones and low bone mass. Osteoporosis can weaken bones and cause them" because bone loss occurs with- out symptoms. Many people may not know that they have osteoporosis until

  2. INFLAMMATORY BOWEL DISEASE: THE INSIDE DISH

    E-Print Network [OSTI]

    Stanford, Kyle

    to be aware of advances that can improve quality of life. UC Irvine Healthcare's H.H. Chao Comprehensive Center at UC Irvine Medical Center. Patients with Crohn's disease or ulcerative colitis benefit from 101 Jocelyne Miller, MD Medication Fix ­ Overview of Medical Treatments Nimisha K. Parekh, MD, MPH

  3. DISEASES OF AQUATIC ORGANISMS Dis Aquat Org

    E-Print Network [OSTI]

    Nizet, Victor

    ), and hybrid striped bass (Evans et al. 2000). Clinical symptoms of S. iniae infection in fish include loss from the freshwater dolphin Inia geoffrensis (Pier & Madin 1976), S. iniae infects a wide range of fish infection in humans who have handled diseased fish (Weinstein et al. 1997). Despite the need for novel

  4. Motor Control Abnormalities in Parkinson's Disease

    E-Print Network [OSTI]

    Motor Control Abnormalities in Parkinson's Disease Pietro Mazzoni, Britne Shabbott, and Juan Camilo Corte´s Motor Performance Laboratory, The Neurological Institute, Columbia University, New York, New. Motor symptoms can also be described in terms of motor control, a level of description that explains how

  5. Disease Prediction Models and Operational Readiness

    SciTech Connect (OSTI)

    Corley, Courtney D.; Pullum, Laura L.; Hartley, David M.; Benedum, Corey M.; Noonan, Christine F.; Rabinowitz, Peter M.; Lancaster, Mary J.

    2014-03-19T23:59:59.000Z

    INTRODUCTION: The objective of this manuscript is to present a systematic review of biosurveillance models that operate on select agents and can forecast the occurrence of a disease event. One of the primary goals of this research was to characterize the viability of biosurveillance models to provide operationally relevant information for decision makers to identify areas for future research. Two critical characteristics differentiate this work from other infectious disease modeling reviews. First, we reviewed models that attempted to predict the disease event, not merely its transmission dynamics. Second, we considered models involving pathogens of concern as determined by the US National Select Agent Registry (as of June 2011). Methods: We searched dozens of commercial and government databases and harvested Google search results for eligible models utilizing terms and phrases provided by public health analysts relating to biosurveillance, remote sensing, risk assessments, spatial epidemiology, and ecological niche-modeling, The publication date of search results returned are bound by the dates of coverage of each database and the date in which the search was performed, however all searching was completed by December 31, 2010. This returned 13,767 webpages and 12,152 citations. After de-duplication and removal of extraneous material, a core collection of 6,503 items was established and these publications along with their abstracts are presented in a semantic wiki at http://BioCat.pnnl.gov. Next, PNNL’s IN-SPIRE visual analytics software was used to cross-correlate these publications with the definition for a biosurveillance model resulting in the selection of 54 documents that matched the criteria resulting Ten of these documents, However, dealt purely with disease spread models, inactivation of bacteria, or the modeling of human immune system responses to pathogens rather than predicting disease events. As a result, we systematically reviewed 44 papers and the results are presented in this analysis.

  6. What You Should Know About Plant Diseases.

    E-Print Network [OSTI]

    Horne, C. Wendell; Smith, Harlan E.

    1962-01-01T23:59:59.000Z

    . From 1845 to 1860, plant disease caused a disaster in Irelantl. Late blight struck the potato- yrowing region and turned the fields into a black- ened, rotting mass. A million people diet1 because I the potato crop failed; numerous families.... OTHER CONDITIONS WHICH MAY CAUSE PLANT IN JURY 1. Drying winds 2. Excessive light 3. Excessive lime in the soil 4. Over-use of commercial fertilizer 5. Gas injury PARASITIC OR SAPROPHYTIC PLANTS MISTLETOE-Mistletoe is a parasitic flowering plant...

  7. Soil Fumigation for Plant Disease Control.

    E-Print Network [OSTI]

    Young, P. A. (Paul Allen); Godfrey, G. H. (George Harold)

    1943-01-01T23:59:59.000Z

    satisfactory results were secured wikh xylene, ethylene dichloride, sodium cyanide and formaldehyde. Paper impregnated wit11 hoof-and-horn glue, casein glue, or vegetttble paste, and adequately sealed at the edges, was most satisfactory for con- fining... of the fumigants were effec- tive when the funligants were tightly confined in the soil. Soil fumigation boxes, made gas-tight by glueing the boards together and sealing the cover, were very effective for confining fumeants to kill plant-disease fungi and other...

  8. Characterization of a Drosophila model of Huntington's disease

    E-Print Network [OSTI]

    Lee, Wyan-Ching Mimi

    2006-01-01T23:59:59.000Z

    Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation ...

  9. Women and Heart Disease: Neglected Directions for Future Research

    E-Print Network [OSTI]

    Barrett-Connor, Elizabeth

    2009-01-01T23:59:59.000Z

    009-9110-0 Women and Heart Disease: Neglected Directions forage 65, women have less heart disease than men. For many1980s showed a lower risk of heart attacks in postmenopausal

  10. Bleb Point: Mimicker of Pneumothorax in Bullous Lung Disease

    E-Print Network [OSTI]

    Gelabert, Christopher; Nelson, Mathew

    2015-01-01T23:59:59.000Z

    G, Biderman P, et al. “The lung point”: an REFERENCESof cystic and bullous lung disease. Chest Surg Clin N Am.S, Kaiser LR. Giant bullous lung disease: chest radiography

  11. alberta kidney disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    for nearly 44 percent of new cases.1 Even when diabetes is controlled, the disease can lead to CKD Baker, Chris I. 2 Kidney Dysplasia National Kidney and Urologic Diseases...

  12. asbestos induced diseases: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    disease in a patient may be a marker for disease in household contacts. Patients with family members heavily exposed to asbestos should be strongly encouraged to quit smoking in...

  13. animal virus diseases: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Physics Websites Summary: Modelling the spread of foot-and-mouth disease virus F Moutou B Durand CNEVA, Laboratoire Central-and-mouth disease is an economically important viral...

  14. animal disease models: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Physics Websites Summary: Modelling the spread of foot-and-mouth disease virus F Moutou B Durand CNEVA, Laboratoire Central-and-mouth disease is an economically important viral...

  15. Should we expect population thresholds for wildlife disease?

    E-Print Network [OSTI]

    Getz, Wayne M.

    of Zoology and Entomology, University of Pretoria, 0002 South Africa 6 Energy and Resources Group, University , Adam B. Smith6 and Andrea Swei4 1 Department of Environmental Science, Policy and Management of infectious disease are core concepts of disease ecology and underlie disease control policies based

  16. Understanding Equine Strangles: Signs of Disease, Management and Prevention1

    E-Print Network [OSTI]

    Watson, Craig A.

    in 1251. The infection is highly contagious in horse populations and can recur on farms with previous outbreaks of the disease. It is one of the most commonly diagnosed contagious diseases of the horse signs of infection. Complications of Disease Fortunately, although strangles is highly contagious

  17. A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN

    E-Print Network [OSTI]

    A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN BY R. R. RUCKER, W. J. WHIPPLE, J. R A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN By R. R. Rucker, W. J. Whipple, J. R. Parvin and C. A #12;A CONTAGIOUS DISEASE OF SALMON, POSSIBLY OF VIRUS ORIGIN By R. R. Rucker,! Fishery Research

  18. Identification of Early Interstitial Lung Disease in Smokers from the

    E-Print Network [OSTI]

    Identification of Early Interstitial Lung Disease in Smokers from the COPDGene Study George R interstitial lung disease (ILD) on chest computed tomographic (CT) scans. Materials and Methods: The CT scans: Early interstitial lung disease; CT scan; smoker. ªAUR, 2010 I diopathic pulmonary fibrosis (IPF

  19. Smoking and Ischemic Heart Disease Disparities Between Studies, Genders, Times, and Socioeconomic Strata

    E-Print Network [OSTI]

    Leistikow, Bruce N.

    2009-01-01T23:59:59.000Z

    predictors of coronary heart disease among women. Americanon the risk for coronary heart disease even stronger thanx Smoking and Ischemic Heart Disease Disparities Between

  20. Impact of Palivizumab on RSV Hospitalizations for Children with Hemodynamically Significant Congenital Heart Disease

    E-Print Network [OSTI]

    Chang, Ruey-Kang R.; Chen, Alex Y.

    2010-01-01T23:59:59.000Z

    in infants with congenital heart disease. Pediatrics 114:children with congenital heart disease. The Cardiac StudySigni?cant Congenital Heart Disease Ruey-Kang R. Chang •

  1. Visualizing Brain Metals in Health and Disease

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron SpinPrincetonUsing Maps1 -Visualizing Brain Metals in Health and Disease

  2. Genetic Contributions to Infectious Disease Risk Infectious disease in cattle production

    E-Print Network [OSTI]

    Life Research, Texas A&M University, West· Texas A&M University, Texas Tech University, and USDA associated with disease resistance. Researchers at Texas AgriLife Research are well positioned to address collaborations including scientists in the College of Veterinary Medicine and Bio- medical Sciences at Texas A

  3. Automated diagnostic kiosk for diagnosing diseases

    DOE Patents [OSTI]

    Regan, John Frederick; Birch, James Michael

    2014-02-11T23:59:59.000Z

    An automated and autonomous diagnostic apparatus that is capable of dispensing collection vials and collections kits to users interesting in collecting a biological sample and submitting their collected sample contained within a collection vial into the apparatus for automated diagnostic services. The user communicates with the apparatus through a touch-screen monitor. A user is able to enter personnel information into the apparatus including medical history, insurance information, co-payment, and answer a series of questions regarding their illness, which is used to determine the assay most likely to yield a positive result. Remotely-located physicians can communicate with users of the apparatus using video tele-medicine and request specific assays to be performed. The apparatus archives submitted samples for additional testing. Users may receive their assay results electronically. Users may allow the uploading of their diagnoses into a central databank for disease surveillance purposes.

  4. Respiratory disease in Utah coal miners

    SciTech Connect (OSTI)

    Rom, W.N.; Kanner, R.E.; Renzetti, A.D. Jr.; Shigeoka, J.W.; Barkman, H.W.; Nichols, M.; Turner, W.A.; Coleman, M.; Wright, W.E.

    1981-04-01T23:59:59.000Z

    Two hundred forty-two Utah underground coal miners volunteered to participate in a respiratory disease study. They were an older group (mean, 56 years of age) and had spent a mean of 29 years in the coal-mining industry. The prevalence of chronic bronchitis was 57%, and that of coal worker's pneumoconiosis, 25%; only one worker had progressive massive fibrosis. Significant impairment of pulmonary function was found among those with a history of cigarette smoking. Chronic bronchitis or coal worker's penumoconiosis among nonsmokers did not impair pulmonary function. There was a significant association among the nonsmokers between increasing exposure to coal dust and coal worker's pneumoconiosis, but not for changes in pulmonary function. Coal mine dust had a significant influence in causing the symptom complex of chronic cough and sputum production, and coal worker's pneumoconiosis.

  5. Respiratory disease in Utah coal miners

    SciTech Connect (OSTI)

    Rom, W.N.; Kanner, R.E.; Renzetti, A.D. Jr.; Shigeoka, J.W.; Barkman, H.W.; Nichols, M.; Turner, W.A.; Coleman, M.; Wright, W.E.

    1981-04-01T23:59:59.000Z

    Two hundred forty-two Utah underground coal miners volunteered to participate in a respiratory disease study. They were an older group (mean, 56 years of age) and had spent a mean of 29 years in the coal-mining industry. The prevalence of chronic bronchitis was 57%, and that of coal worker's pneumoconiosis, 25%; only one worker had progressive massive fibrosis. Significant impairment of pulmonary function was found among those with a history of cigarette smoking. Chronic bronchitis or coal worker's pneumoconiosis among nonsmokers did not impair pulmonary function. There was a significant association among the nonsmokers between increasing exposure to coal dust and coal worker's pneumoconiosis, but not for changes in pulmonary function. Coal mine dust had a significant influence in causing the symptom complex of chronic cough and sputum production, and coal worker's pneumoconiosis.

  6. Optical detection dental disease using polarized light

    DOE Patents [OSTI]

    Everett, Matthew J. (Livermore, CA); Colston, Jr., Billy W. (Livermore, CA); Sathyam, Ujwal S. (Livermore, CA); Da Silva, Luiz B. (Danville, CA); Fried, Daniel (San Francisco, CA)

    2003-01-01T23:59:59.000Z

    A polarization sensitive optical imaging system is used to detect changes in polarization in dental tissues to aid the diagnosis of dental disease such as caries. The degree of depolarization is measured by illuminating the dental tissue with polarized light and measuring the polarization state of the backscattered light. The polarization state of this reflected light is analyzed using optical polarimetric imaging techniques. A hand-held fiber optic dental probe is used in vivo to direct the incident beam to the dental tissue and collect the reflected light. To provide depth-resolved characterization of the dental tissue, the polarization diagnostics may be incorporated into optical coherence domain reflectometry and optical coherence tomography (OCDR/OCT) systems, which enables identification of subsurface depolarization sites associated with demineralization of enamel or bone.

  7. Chronic Beryllium Disease Prevention Program Report

    SciTech Connect (OSTI)

    Lee, S

    2012-03-29T23:59:59.000Z

    This document describes how Lawrence Livermore National Laboratory (LLNL) meets the requirements and management practices of federal regulation 10 CFR 850, 'Chronic Beryllium Disease Prevention Program (CBDPP).' This revision of the LLNL CBDPP incorporates clarification and editorial changes based on lessons learned from employee discussions, observations and reviews of Department of Energy (DOE) Complex and commercial industry beryllium (Be) safety programs. The information is used to strengthen beryllium safety practices at LLNL, particularly in the areas of: (1) Management of small parts and components; and (2) Communication of program status to employees. Future changes to LLNL beryllium activities and on-going operating experience will be incorporated into the program as described in Section S, 'Performance Feedback.'

  8. Does aluminum smelting cause lung disease

    SciTech Connect (OSTI)

    Abramson, M.J.; Wlodarczyk, J.H.; Saunders, N.A.; Hensley, M.J.

    1989-04-01T23:59:59.000Z

    The evidence concerning a relationship between work in the aluminum industry and lung disease has been reviewed using epidemiologic criteria. Adequate data on environmental exposure are rarely presented. Case series on aluminum potroom workers over the past 50 years have identified an asthmalike syndrome that appears to be due to an irritant rather than an allergic mechanism. These studies have been supported by evidence of within shift variability of measures of lung function. However, to date, there is inadequate evidence to resolve the question of whether potroom exposure initiates asthma or merely precipitates asthmalike symptoms in a predisposed individual. Cross-sectional studies have demonstrated evidence of reduced lung function, consistent with chronic airflow limitation. In exposed aluminum smelter workers compared to unexposed control subjects. Cigarette smoking, the major potential confounding variable, has been measured and accounted for in multivariate analyses. To date, evidence is lacking from longitudinal studies about the development of disabling chronic obstructive lung disease. Exposure to coal tar pitch volatiles in the production and consumption of anodes has biologic plausibility for an association of lung cancer with work in an aluminum smelter. Although retrospective mortality studies have failed to account for the probable high prevalence of smoking in blue collar workers, the relative risk of lung cancer is very low if present at all. Pulmonary fibrosis has not been shown to be a significant problem in aluminum smelter workers. Future research in the aluminum industry needs to concentrate on longitudinal studies, preferably with an inception cohort for the investigation of potroom asthma. 92 references.

  9. Thiacetarsamide therapy of heartworm disease in cats: a pharmacokinetic study

    E-Print Network [OSTI]

    Turner, Janet Lynn

    1988-01-01T23:59:59.000Z

    . Coughing and exerci se intolerance are common clinical signs. Coughing may be related to the severe pulmonary arterial disease or may be due to pneumonitis induced by the heartworm ~nfection. Severe cases of dirofilariasis may have hemoptysis... intermittent coughing and dyspnea, as well as anorexia and vomiting. Necropsies of cats with heartworm disease usually demonstrate a low worm burden. ' Cardiomegaly is less common in cats than in 23, 30-34 dogs with heartworm disease. Pulmonary arterial...

  10. Neuronal Protection by a Novel C-terminal Hsp90 Modulator

    E-Print Network [OSTI]

    Menchen, Heather Ann

    2012-08-31T23:59:59.000Z

    Alzheimer's disease (AD), like most neurodegenerative disorders, is characterized by accumulation of misfolded and aggregated proteins, indicating that the protein quality control machinery is compromised. Enhancing the ...

  11. ad mild cognitive: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    56, 52-60. space is visualized Wang, Yalin 5 Cognitive and affective theory of mind in mild to moderate Alzheimer's disease Computer Technologies and Information Sciences...

  12. apolipoprotein a-i significance: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Parasuraman, Raja 23 Prospective Memory and Apolipoprotein E in Healthy Aging and Early Stage Alzheimer's Disease Biology and Medicine Websites Summary: Prospective Memory and...

  13. Statistical shape analysis of neuroanatomical structures based on spherical wavelet transformation

    E-Print Network [OSTI]

    Yu, Peng, Ph. D. Massachusetts Institute of Technology

    2008-01-01T23:59:59.000Z

    Evidence suggests that morphological changes of neuroanatomical structures may reflect abnormalities in neurodevelopment, or relate to a variety of disorders, such as schizophrenia and Alzheimer's disease (AD). Advances ...

  14. nAture methods | VOL.10 NO.2 | FEBRUARY2013 | 147 measurement of protease activity in living cells or organisms

    E-Print Network [OSTI]

    Cai, Long

    , such as gout6, atherosclerosis7, type 2 diabetes8 and Alzheimer's disease9, engagement of the NLRP3­ASC

  15. antimicrobial peptides isolated: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    has attracted surprisingly Maurice Charlet; Serguey Chernysh; Charles Hetru; Jules A. Hoffmann 2 Alzheimer's Disease Antimicrobial Peptides Mathematics Websites Summary: Keywords...

  16. antimicrobial peptide isolated: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    has attracted surprisingly Maurice Charlet; Serguey Chernysh; Charles Hetru; Jules A. Hoffmann 2 Alzheimer's Disease Antimicrobial Peptides Mathematics Websites Summary: Keywords...

  17. Nanofluidic Biosensing for -Amyloid Detection Using Surface Enhanced

    E-Print Network [OSTI]

    Cote, Gerard L

    Nanofluidic Biosensing for -Amyloid Detection Using Surface Enhanced Raman Spectroscopy I a large impact in understanding and diagnosing Alzheimer's disease. We demonstrate how a novel nanofluidic

  18. avium complex disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Characterizing SNP-Disease Associations Using Bayesian Networks University of Kansas - KU ScholarWorks Summary: of computational methods in epistatic interaction...

  19. aleutian mink disease virus: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    cause diseases with long incubation periods, insidious onsets, and slowly progressive courses (1). The members of the virus group include visna virus of sheep, caprine...

  20. aleutian disease virus: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    cause diseases with long incubation periods, insidious onsets, and slowly progressive courses (1). The members of the virus group include visna virus of sheep, caprine...

  1. asbestos-related pleuropulmonary diseases: Topics by E-print...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    diseases Ulcer treatment has been revolutionized by recently discovered knowledge about Helicobacter pylori, a bacterium commonly found in the human gastrointestinal tract. These...

  2. adnexal diseases: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    diseases Ulcer treatment has been revolutionized by recently discovered knowledge about Helicobacter pylori, a bacterium commonly found in the human gastrointestinal tract. These...

  3. anus diseases: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    diseases Ulcer treatment has been revolutionized by recently discovered knowledge about Helicobacter pylori, a bacterium commonly found in the human gastrointestinal tract. These...

  4. assessing disease activity: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    marked geographic clustering, and lack of reliable data on incidence, duration, and impact of the various disease syndromes. Non-health effects such as impoverishment,...

  5. adult kawasakis disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    association. Renee D. Goodwin; Daniel S. Pine 24 MRI-based Three dimensional shape analysis of thigh muscles: people with Chronic Obstructive Pulmonary Disease versus healthy...

  6. Genomics of emerging infectious disease: A PLoS collection.

    E-Print Network [OSTI]

    Eisen, Jonathan A; MacCallum, Catriona J

    2009-01-01T23:59:59.000Z

    Origins and evolutionary genomics of the 2009 swine-originan Infectious Diseases Genomics Project predict and preventRavel J (2009) The role of genomics in the identification,

  7. Recombinant herpes simplex virus useful for treating neoplastic disease

    DOE Patents [OSTI]

    Whitley, Richard J.; Roizman, Bernard

    2010-06-29T23:59:59.000Z

    Recombinant herpes simplex viruses comprising DNA encoding cytokines and methods for treating neoplastic diseases using the inventive recombinant viruses are disclosed.

  8. Do changes in traditional coronary heart disease risk factors over time explain the association between socio-economic status and coronary heart disease?

    E-Print Network [OSTI]

    Franks, Peter; Winters, Paul C; Tancredi, Daniel J; Fiscella, Kevin A

    2011-01-01T23:59:59.000Z

    case-control study. Heart 2009, Franks P, Tancredi DJ,status in coronary heart disease risk estimation. Ann Famstatus and coronary heart disease risk prediction. JAMA

  9. Diseases of plantation forestry trees in eastern and southern Africa

    E-Print Network [OSTI]

    Diseases of plantation forestry trees in eastern and southern Africa J. Roux a*, G. Meke b , B are being allocated to the training of forestry staff andtreeimprovement.Theseefforts,aimedatstrengtheningthe forestry business, also embrace research on pests and diseases that might significantly reduce the value

  10. Harnessing plasticity to understand learning and treat disease

    E-Print Network [OSTI]

    Kilgard, Michael P.

    Harnessing plasticity to understand learning and treat disease Michael P. Kilgard The University, USA A large body of evidence suggests that neural plasticity contributes to learning and disease. Recent studies sug- gest that cortical map plasticity is typically a transient phase that improves

  11. Lung Disease in Pediatrics: is it all in the Genes?

    E-Print Network [OSTI]

    Lung Disease in Pediatrics: is it all in the Genes? Jay K. Kolls, M.D.Jay K. Kolls, M.D. Chair with CF do worse than other? #12;· Outcomes are better at CF centers · There is huge variation in lung with the same mutation do worse than others? · Modifier genes ­ lung disease ­ Tgfb1 ­ Irfd1 ­ neutrophil

  12. Original article Lentivirus-induced interstitial lung disease

    E-Print Network [OSTI]

    Boyer, Edmond

    Original article Lentivirus-induced interstitial lung disease: pulmonary pathology in sheep a chronic disease in sheep affecting, among other organs, the lungs. Interstitial pneumonitis is similar the pathological features of lungs of sheep naturally infected with visna-maedi virus with the results obtained

  13. Asbestos-related pulmonary disease in boilermakers

    SciTech Connect (OSTI)

    Demers, R.Y.; Neale, A.V.; Robins, T.; Herman, S.C. (Wayne State Univ., Detroit, MI (USA))

    1990-01-01T23:59:59.000Z

    Boilermakers are skilled building tradesmen who construct, repair, and dismantle boilers. The present study reports on the evaluation of members of a Michigan boilermaker's union for the presence of signs and symptoms of chronic pulmonary disease. Study variables included standardized evaluations of chest x-ray findings, pulmonary function testing, physical examination, and respiratory symptoms. An overall participation rate of 69% was achieved. A non-participant survey identified no significant differences between participants and non-participants in dyspnea, cough, age, or smoking history. Among participants with greater than 20 years experience in the trade, the mean FVC was 91% of predicted; the FEV1 was 86% of predicted; 25% showed at least a 1/0 profusion of interstitial markings on chest x-ray; 30% had bilateral pleural abnormalities; and 52% had audible inspiratory rales on physical examination. Forced vital capacity and forced expiratory volume at one second both decreased with years in the trade. Chest x-ray findings of interstitial fibrosis and pleural plaques were related to ten or more years in the trade, as were respiratory symptoms of pulmonary rales, wheeze, and dyspnea.

  14. Efficient Time Series Matching by Wavelets Kinpong Chan and Ada Waichee Fu

    E-Print Network [OSTI]

    Fu, Ada Waichee

    since the effectiveness of power concentration of a partic­ ular transformation depends on the nature to other problems. While large pieces reduce the power of multi­resolution, small pieces has weakness­Trees for fast retrieval. Due to the dimensionality curse problem, transformations are applied to time series

  15. ada-deficient severe combined: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    James A Zwiebel; Eli Gilboa; R Michael Blaese; Arthur Nienhuis; Richard J O& apos; reilly; W. French Anderson 1987-01-01 12 Spatial joins are one of the most important...

  16. Long Range Campus Development Plan ADA The abbreviation for Americans with Disabilities Act.

    E-Print Network [OSTI]

    Maxwell, Bruce D.

    is the student government association serving as the elected voice of the students of Montana State University to simultaneously generate both electricity and useful heat. Districts A district is an area of concentrated similar The abbreviation for the Facilities Planning, Design and Construction department within University Services. FTE

  17. ada2p yields insight: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the United States Environmental Sciences and Ecology Websites Summary: of this grass as a bioenergy crop, these studies have not been integrated. In this study, we present and...

  18. Colorado School of Mines Americans with Disabilities Act (ADA) Request Procedures

    E-Print Network [OSTI]

    diversity and inclusion at Mines. These actions will include, but are not limited to, the making as help during an emergency evacuation) because of a medical condition; C) To individuals investigating

  19. ada-europe international conference: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fuels Websites Summary: , Simulation and Environmental Impact of Energy systems turku Finland Call for Papers ECOS2014- 27th International Conference on Efficiency, Cost,...

  20. Automatic Performance Management in Component Based Software Systems Ada Diaconescu1

    E-Print Network [OSTI]

    of component-based enterprise applications is presented. A non-intrusive monitoring and diagnosis module by integrating low-overhead and non-intrusive monitoring with application adaptation techniques. The framework is inserted in the components upon a non-intrusive introspection process Application Server Component

  1. Ada County, Idaho ASHRAE 169-2006 Climate Zone | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to:Ezfeedflag JumpID-fTriWildcat 1AMEE Jump to:

  2. Quantum Leaps in Disease Detection Luis Garcia-Rubio, Ph.D.

    E-Print Network [OSTI]

    Meyers, Steven D.

    Quantum Leaps in Disease Detection Luis Garcia-Rubio, Ph.D. USF researchers are making quantum leaps in disease detection with the develop- ment of portable biosensors that can detect deadly diseases

  3. autoimmune disease triggered: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    disease (PD), to date there is still no definite cause or accepted treatment Hlava, Debbie Joy 2012-01-01 44 One (1) Postdoctoral position available at IMBB-FORTH, Heraklion,...

  4. artery disease results: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 49 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  5. artery disease evaluation: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GIUSEPPE, RACHELE 2012-01-01 53 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  6. artery disease share: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    David Andrew 2007-01-01 49 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  7. artery disease combined: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 52 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  8. artery disease focus: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 49 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  9. artery disease metabolismo: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 40 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  10. artery disease quantification: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 49 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  11. artery disease studied: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    pressure Hielscher, Andreas 8 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  12. artery disease selection: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Andrew J. Lees 1991-01-01 56 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  13. artery disease trial: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 50 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  14. arterial occlusive disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 65 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  15. artery disease potential: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    fo... Yi, Li Ting 2013-01-01 56 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  16. artery disease involving: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    E. Lundquist; James P. Ward 60 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  17. artery disease comparison: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 45 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  18. artery disease left: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Du Toit, Henning 2007-01-01 52 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  19. artery disease assessed: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 60 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  20. artery disease longitudinal: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 51 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  1. artery disease cad: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hanson, Stephen Jos 18 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  2. arterial occlusive diseases: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 65 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  3. artery disease drugs: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 74 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  4. artery disease outcomes: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 53 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  5. artery disease undergoing: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 42 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  6. artery disease accuracy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 42 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  7. artery disease 24-month: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 40 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  8. artery disease assessment: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 60 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  9. artery disease increased: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mervyn J. Monteiro 1997-01-01 52 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  10. artery occlusive disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 65 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  11. artery disease stroke: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A; Bachmann, Max O 2011-02-28 72 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  12. artery disease evaluated: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GIUSEPPE, RACHELE 2012-01-01 53 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  13. artery disease insights: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 50 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  14. arterial disease study: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    pressure Hielscher, Andreas 8 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  15. arterial disease severity: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    with chronic Roche, Benjamin 62 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  16. artery disease severity: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    with chronic Roche, Benjamin 62 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  17. artery disease subanalysis: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 38 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  18. arterial disease lack: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 42 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  19. ameliorate coral disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Functionally diverse reef-fish communities ameliorate coral disease Biology and Medicine Websites Summary:...

  20. advanced hiv disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HIV-1 infection, with extremes of very rapid disease progression (,2 years) and long-term non-progression (.15 years). To reveal additional host genetic factors that may impact on...

  1. Medicating race : heart disease and durable preoccupations with difference

    E-Print Network [OSTI]

    Pollock, Anne, 1975-

    2007-01-01T23:59:59.000Z

    This dissertation is an examination of intersections of race, pharmaceuticals, and heart disease over the course of the 20th century and today. Each of these parts has had a dynamic history, and when they are invoked ...

  2. Intrinsically Disordered Proteins: Regulation and Disease Regulation of IDPs

    E-Print Network [OSTI]

    Babu, M. Madan

    31st Jan 2011 Intrinsically Disordered Proteins: Regulation and Disease Regulation of IDPs M. Madan ...........................................................................................................................................................................1 2. The need for regulating IDPs.................................................................................................................................................1 3. General principles of IDP regulation

  3. Striatal origin of the pathologic beta oscillations in Parkinson's disease

    E-Print Network [OSTI]

    Boyden, Edward Stuart

    Enhanced oscillations at beta frequencies (8–30 Hz) are a signature neural dynamic pathology in the basal ganglia and cortex of Parkinson's disease patients. The mechanisms underlying these pathological beta oscillations ...

  4. Modelling power-law spread of infectious diseases

    E-Print Network [OSTI]

    Meyer, Sebastian

    2013-01-01T23:59:59.000Z

    Short-time human travel behaviour can be well described by a power law with respect to distance. We incorporate this information in space-time models for infectious disease surveillance data to better capture the dynamics of disease spread. Two previously established model classes are extended, which both decompose disease risk additively into endemic and epidemic components: a space-time point process model for individual point-referenced data, and a multivariate time series model for aggregated count data. In both frameworks, the power-law spread is embedded into the epidemic component and its decay parameter is estimated simultaneously with all other unknown parameters using (penalised) likelihood inference. The performance of the new approach is investigated by a re-analysis of individual cases of invasive meningococcal disease in Germany (2002-2008), and count data on influenza in 140 administrative districts of Southern Germany (2001-2008). In both applications, the power-law formulations substantially ...

  5. A PROTEOMIC STUDY OF OXIDATIVE STRESS IN ALCOHOLIC LIVER DISEASE

    E-Print Network [OSTI]

    Newton, Billy W.

    2010-01-16T23:59:59.000Z

    Alcoholic steatosis (AS) is the initial pathology associated with early stage alcoholic liver disease and is characterized by the accumulation of fat in the liver. AS is considered clinically benign as it is reversible, as compared with alcoholic...

  6. Human alkaloid biosynthesis : chemical inducers of Parkinson's disease?

    E-Print Network [OSTI]

    Hatzios, Stavroula K. (Stavroula-Artemis K.)

    2005-01-01T23:59:59.000Z

    The occurrence of certain alkaloids in the human brain appears to be associated with the onset of Parkinson's disease (PD). Recently, a human protein bearing homology to an alkaloid synthase in plants was identified. This ...

  7. Real-time Raman system for in vivo disease diagnosis

    E-Print Network [OSTI]

    Motz, Jason T.

    Raman spectroscopy has been well established as a powerful in vitro method for studying biological tissue and diagnosing disease. The recent development of efficient, high-throughput, low-background optical fiber Raman ...

  8. Dopamine Release and Uptake in Animal Models of Neurological Diseases

    E-Print Network [OSTI]

    Fulks, Jenny Lynn

    Fast scan cyclic voltammetry (FSCV) can be utilized to detect neurotransmitter release and uptake in brain slices. When combining this technique with disease state animals models, information for therapeutic targets can ...

  9. Quantitative Neuroimaging : : Applications to Normal Aging and Neurodegenerative Disease

    E-Print Network [OSTI]

    Murphy, Elizabeth Ann

    and metabolism of lipoproteins. Ann Endocrinol 44(1), 59-65.Disease by Elizabeth Ann Murphy Doctor of Philosophy ina tale of two proteins. Ann Neurol. 2006;59(3);449-458.

  10. Huntington's Disease: Can Mice Lead the Way to Treatment?

    E-Print Network [OSTI]

    Crook, Zachary Ryan

    Mouse models for Huntington's Disease (HD) and HD patients demonstrate motor and behavioral dysfunctions, such as progressive loss of coordination and memory, and share similar transcriptional profiles and striatal neuron ...

  11. Array-based detection of genetic alterations associated with disease

    DOE Patents [OSTI]

    Pinkel, Daniel; Albertson, Donna G.; Gray, Joe W.

    2007-09-11T23:59:59.000Z

    The present invention relates to DNA sequences from regions of copy number change on chromosome 20. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases.

  12. A biophysical marker of severity in sickle cell disease

    E-Print Network [OSTI]

    Mahadevan, L.

    The search for predictive indicators of disease has largely focused on molecular markers. However, biophysical markers, which can integrate multiple pathways, may provide a more global picture of pathophysiology. Sickle ...

  13. Timing of testing and treatment for asymptomatic diseases

    SciTech Connect (OSTI)

    K?rk?zlar, Eser [State Univ. of New York (SUNY), Plattsburgh, NY (United States); Faissol, Daniel M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Griffin, Paul M. [Pennsylvania State Univ., State College, PA (United States); Swann, Julie L. [Georgia Inst. of Technology, Atlanta, GA (United States)

    2010-07-01T23:59:59.000Z

    Many papers in the medical literature analyze the cost-effectiveness of screening for diseases by comparing a limited number of a priori testing policies under estimated problem parameters. However, this may be insufficient to determine the best timing of the tests or incorporate changes over time. In this paper, we develop and solve a Markov Decision Process (MDP) model for a simple class of asymptomatic diseases in order to provide the building blocks for analysis of a more general class of diseases. We provide a computationally efficient method for determining a cost-effective dynamic intervention strategy that takes into account (i) the results of the previous test for each individual and (ii) the change in the individual’s behavior based on awareness of the disease. We demonstrate the usefulness of the approach by applying the results to screening decisions for Hepatitis C (HCV) using medical data, and compare our findings to current HCV screening recommendations.

  14. 452 Plant Disease / Vol. 82 No. 5 A. R. Biggs

    E-Print Network [OSTI]

    Biggs, Alan R.

    452 Plant Disease / Vol. 82 No. 5 A. R. Biggs West Virginia University, Kearneysville G. G. Grove-illustrated "fact sheets" Dr. Biggs' address is: West Virginia University, University Experiment Farm, P. O. Box 609

  15. Nature of language impairment in motor neurone disease 

    E-Print Network [OSTI]

    Rewaj, Phillipa Jane

    2014-07-01T23:59:59.000Z

    Background: Language impairment associated with Motor Neurone Disease (MND) has been documented since the late 19th century, yet little is understood about the pervasiveness or nature of these deficits. The common clinical ...

  16. acute liver disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    primary biliary cirrhosis (PBC) are progressive autoimmune liver diseases (AiLD) that can lead to liver cirrhosis, hepatic (more) Ngu, Jing Hieng 2013-01-01 3 P ICHAI et al...

  17. RESEARCH OF ANIMAL DISEASE INFORMATION SYSTEM BASED ON GIS

    E-Print Network [OSTI]

    Boyer, Edmond

    RESEARCH OF ANIMAL DISEASE INFORMATION SYSTEM BASED ON GIS TECHNOLOGY Hongbin Wang *, Lin Li, Jing.1007/978-3-642-12220-0_9 #12;2 Hongbin Wang, Lin Li, Jing Dong, Danning Xu, Jing Li distribution. It is evident

  18. Disease Ecology: Community Structure and Pathogen Dynamics [Review

    E-Print Network [OSTI]

    Peterson, A. Townsend

    2007-01-01T23:59:59.000Z

    BOOKS & MEDIA Disease Ecology: Community Structure and Pathogen Dynamics Sharon K. Collinge and Chris Ray, editors Oxford University Press, Cary, North Carolina, 2006 ISBN: 0198567073 Pages: 227; Price: US $124.50 The disciplines of community...

  19. CENTERS FOR DISEASE CONTROL ,,~V'CIl'1I

    E-Print Network [OSTI]

    EXECUTIVESECRETARY Houk, Vernon N., M.D. Director Center for Environmental Health Centers for Disease Conlrol Atlanla Hahnemann UniversilY Broad and Vine Streets Philadelphia, Pennsylvania 19102 Cole, Jerome F., S

  20. Host nutrition and infectious disease: an ecological view

    E-Print Network [OSTI]

    Smith, Val H.; Jones II, Tyrees P.; Smith, Marilyn S.

    2005-06-01T23:59:59.000Z

    Nutrition is typically discussed in terms of maintaining a proper diet and avoiding nutrient deficiency diseases. However, nutrition can also be viewed from an ecological standpoint: mammalian hosts and their pathogens ...

  1. CORAL HEALTH AND DISEASE: A COMPARISON OF COOK’S AND ‘OPUNOHU BAYS IN MOOREA, FRENCH POLYNESIA

    E-Print Network [OSTI]

    Shea, Alessandra

    2011-01-01T23:59:59.000Z

    Predictive  Modeling  of  Coral  Disease  Distribution Baseline levels of coral disease  in  the  northwestern 2011.   Patterns  of  Coral  Disease  across  Hawaiian 

  2. Engineering disease resistance with pectate lyase-like genes

    DOE Patents [OSTI]

    Vogel, John; Somerville, Shauna

    2005-03-08T23:59:59.000Z

    A mutant gene coding for pectate lyase and homologs thereof is provided, which when incorporated in transgenic plants effect an increased level disease resistance in such plants. Also is provided the polypeptide sequence for the pectate lyase of the present invention. Methods of obtaining the mutant gene, producing transgenic plants which include the nucleotide sequence for the mutant gene and producing improved disease resistance in a crop of such transgenic plants are also provided.

  3. Digital subtraction angiography in pediatric cerebrovascular occlusive disease

    SciTech Connect (OSTI)

    Faerber, E.N.; Griska, L.A.B.; Swartz, J.D.; Capitanio, M.A.; Popky, G.L.

    1984-08-01T23:59:59.000Z

    While conventional angiography has been used to demonstrate cerebrovascular occlusive disease in the past, digital subtraction angiography (DSA) is capable of showing progressive vascular involvement with ease, simplicity, and extremely low morbidity, making it particularly well suited for children and outpatients either alone or coordinated with computed tomography. The authors discuss the usefulness and advantages of DSA as demonstrated in 7 infants and children with hemiplegia, 4 of whom had sickle-cell disease.

  4. Field Diseases of the Sweet Potato in Texas.

    E-Print Network [OSTI]

    Taubenhaus, J. J. (Jacob Joseph)

    1919-01-01T23:59:59.000Z

    TEXAS AGRICULTURAL EXPERIMENT STATION AGRICULTURAL AND MECHANICAL COLLEGE OF TEXAS W. B. BIZZELL. President BULLETIN NO. 249 SEPTEMBER, 1919 DIVISION OF PLANT PATHOLOGY AND PHYSIOLOGY FIELD DISEASES OF THE SWEET POTATO IN TEXAS B. YOUNGBLO OD... Medicine. A: & M. College of Texas. 'In cooperatloll with the Unlted States Department of A,mculture. . tIn cooperation with School of Agriculture, A. & M. College of Texas. - BULLETIN NO. 249. SEPTEMBER, 1 919. FIELD DISEASES OF THE SWEET POTATO...

  5. Structural Genomics and Drug Discovery for Infectious Diseases

    SciTech Connect (OSTI)

    Anderson, W.F.

    2010-09-03T23:59:59.000Z

    The application of structural genomics methods and approaches to proteins from organisms causing infectious diseases is making available the three dimensional structures of many proteins that are potential drug targets and laying the groundwork for structure aided drug discovery efforts. There are a number of structural genomics projects with a focus on pathogens that have been initiated worldwide. The Center for Structural Genomics of Infectious Diseases (CSGID) was recently established to apply state-of-the-art high throughput structural biology technologies to the characterization of proteins from the National Institute for Allergy and Infectious Diseases (NIAID) category A-C pathogens and organisms causing emerging, or re-emerging infectious diseases. The target selection process emphasizes potential biomedical benefits. Selected proteins include known drug targets and their homologs, essential enzymes, virulence factors and vaccine candidates. The Center also provides a structure determination service for the infectious disease scientific community. The ultimate goal is to generate a library of structures that are available to the scientific community and can serve as a starting point for further research and structure aided drug discovery for infectious diseases. To achieve this goal, the CSGID will determine protein crystal structures of 400 proteins and protein-ligand complexes using proven, rapid, highly integrated, and cost-effective methods for such determination, primarily by X-ray crystallography. High throughput crystallographic structure determination is greatly aided by frequent, convenient access to high-performance beamlines at third-generation synchrotron X-ray sources.

  6. Non-Chemical Control of Plant Diseases in the Home Garden

    E-Print Network [OSTI]

    Philley, George L.; Kaufman, Harold W.

    2000-02-16T23:59:59.000Z

    Plant diseases can be caused by certain organisms or by environmental factors. This publication discusses non-chemical methods that suppress disease-causing organisms....

  7. Smoking and Ischemic Heart Disease Disparities Between Studies, Genders, Times, and Socioeconomic Strata

    E-Print Network [OSTI]

    Leistikow, Bruce N.

    2009-01-01T23:59:59.000Z

    United States White heart disease mortality rates by gender–year–years of education, ages 25–64 years Heart disease death rate*

  8. Rheumatic Heart Disease and Beta-hemolytic Streptococci in Salvador, Brazil: A Study of Slum Health

    E-Print Network [OSTI]

    Tartof, Sara Yee

    2010-01-01T23:59:59.000Z

    rheumatic fever and rheumatic heart disease in Africa. S Afrthe chain that links the heart to the throat? Lancet Infectchildren with rheumatic heart disease. J Thorac Cardiovasc

  9. Thoracic irradiation in Hodgkin's disease: Disease control and long-term complications

    SciTech Connect (OSTI)

    Tarbell, N.J.; Thompson, L.; Mauch, P. (Harvard Medical School, Boston, MA (USA))

    1990-02-01T23:59:59.000Z

    A total of 590 patients with Stage IA-IIIB Hodgkin's disease received mantle irradiation at the Joint Center for Radiation Therapy between April 1969 and December 1984 as part of their initial treatment. Recurrence patterns as well as pulmonary, cardiac and thyroid complications were analyzed. Pulmonary recurrence was more frequently seen in patients with large mediastinal adenopathy (LMA); 11% of patients with LMA recurred in the lung in contrast to 3.1% with small or no mediastinal disease, p = 0.003. Hilar involvement, when corrected for size of mediastinal involvement, was not predictive of lung relapse. Patients with LMA also had a high rate of nodal relapse above the diaphragm (40%) following radiation therapy (RT) alone as compared to similarly treated patients with small or no mediastinal adenopathy (6.5%), p less than 0.0001. This risk of nodal recurrence was greatly reduced (4.7%) for LMA patients receiving combined radiation therapy and chemotherapy (CMT), p less than 0.0001. Sixty-seven patients (11%) with hilar or large mediastinal involvement received prophylactic, low dose, whole lung irradiation. No decrease in the frequency of lung recurrence was seen with the use of whole lung irradiation. Radiation pneumonitis was seen in 3% of patients receiving radiation therapy alone. In contrast, the use of whole lung irradiation was associated with a 15% risk of pneumonitis, p = 0.006. The risk of pneumonitis was also significantly increased with the use of chemotherapy (11%), p = 0.0001. Cardiac complications were uncommon with pericarditis being the most common complication (2.2%). Thyroid dysfunction was seen in 25% of patients and appeared to be age-related. These data suggest that the long-term complications of mantle irradiation are uncommon with the use of modern radiotherapeutic techniques.

  10. Costs of chronic disease and an alternative to reduce these costs: case study of End Stage Renal Disease (ESRD)

    E-Print Network [OSTI]

    Jang, Won-Ik

    2005-02-17T23:59:59.000Z

    COSTS OF CHRONIC DISEASE AND AN ALTERNATIVE TO REDUCE THESE COSTS: CASE STUDY OF END STAGE RENAL DISEASE (ESRD) A Dissertation by WON-IK JANG Submitted to the Office of Graduate Studies of Texas A&M University in partial...) A Dissertation by WON-IK JANG Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY Approved as to style and content by...

  11. Disease-Specific Symptoms and Health-Related Quality of Life in Children and Adolescents with Inflammatory Bowel Disease

    E-Print Network [OSTI]

    Vaughan-Dark, Chelsea Ann

    2013-07-17T23:59:59.000Z

    , & Tennen, 2006). Therefore, HRQOL provides valuable information about patient outcomes in terms of successful adaptation to chronic illness (Livneh, 2001; Varni, Burwinkle, & Lane, 2005). Although HRQOL is a broad concept that may encompass a number...; Cortina, McGraw, deAlarcon, Rothenberg, & Drotar, 2010; Varni et al., 2006; Varni et al., 2007). Within the category of gastrointestinal disorders, Crohn?s disease and ulcerative colitis, two conditions subsumed under the overarching disease category...

  12. Association Between Celiac Disease and Iron Deficiency in Caucasians, but not Non-Caucasians

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    autoimmune gastritis, Helicobacter pylori and celiac diseaserole of celiac disease, helicobacter pylori, and autoimmune

  13. Curr Pharm Des . Author manuscript Bisphosphonates and bone diseases: past, present and future

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    involving excessive bone resorption which include post-menopausal osteoporosis, Paget s disease of bone

  14. Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The

    E-Print Network [OSTI]

    Hammock, Bruce D.

    Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease contributes to the development of coronary heart disease (CHD). Soluble epoxide hydrolase metabolizes as a potential cardiovascular disease- susceptibility gene. INTRODUCTION Coronary heart disease (CHD) is a major

  15. 17?-Estradiol and Progesterone Regulate Expression of ?-Amyloid Clearance Factors in Primary Neuron Cultures and Female Rat Brain

    E-Print Network [OSTI]

    Jayaraman, Anusha; Carroll, Jenna C.; Morgan, Todd E.; Lin, Sharon; Zhao, Liqin; Arimoto, Jason M.; Murphy, M. Paul; Beckett, Tina L.; Finch, Caleb E.; Brinton, Roberta Diaz; Pike, Christian J.

    2012-01-01T23:59:59.000Z

    polymorphism. Ann NY Acad Sci 1019: 24–28 7. Henderson VW, Buckwalter JG 1994 Cognitive deficits of men and women with Alzheimer’s disease. Neurology 44:90–96 8. Barnes LL,Wilson RS, Bienias JL, Schneider JA, Evans DA, Bennett DA 2005 Sex differences...:833–837 10. Rosario ER, Chang L, Head EH, Stanczyk FZ, Pike CJ 2011 Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer’s disease. Neurobiol Aging 32:604–613 11. Yue X, LuM, Lancaster T, Cao P, Honda S, Staufenbiel...

  16. esyN: Network Building, Sharing and Publishing

    E-Print Network [OSTI]

    Bean, Daniel M.; Heimbach, Joshua; Ficorella, Lorenzo; Micklem, Gos; Oliver, Stephen G.; Favrin, Giorgio

    2014-09-02T23:59:59.000Z

    esyN: Network Building, Sharing and Publishing Daniel M. Bean1,2, Joshua Heimbach1, Lorenzo Ficorella1,2,3, Gos Micklem1,4, Stephen G. Oliver1,2, Giorgio Favrin1,2* 1Cambridge Systems Biology Centre, University of Cambridge, Cambridge, United... identifies APOE epsilon4 effectors in Alzheimer’s disease. Nature 500: 45–50. 27. Shang H, Liu G, Jiang Y, Fu J, Zhang B, et al. (2014) Pathway Analysis of Two Amyotrophic Lateral Sclerosis GWAS Highlights Shared Genetic Signals with Alzheimer’s Disease...

  17. Compositions and Methods for the Treatment of Pierce's Disease

    DOE Patents [OSTI]

    Gupta, Goutam (Santa Fe, NM)

    2008-10-07T23:59:59.000Z

    Chimeric anti-microbial proteins, compositions, and methods for the therapeutic and prophylactic treatment of plant diseases caused by the bacterial pathogen Xylella fastidiosa are provided. The anti-microbial proteins of the invention generally comprise a surface recognition domain polypeptide, capable of binding to a bacterial membrane component, fused to a bacterial lysis domain polypeptide, capable of affecting lysis or rupture of the bacterial membrane, typically via a fused polypeptide linker. In particular, methods and compositions for the treatment or prevention of Pierce's disease of grapevines are provided. Methods for the generation of transgenic Vitus vinefera plants expressing xylem-secreted anti-microbial chimeras are also provided.

  18. Sex affects health: women are different I. Body composition & metabolism

    E-Print Network [OSTI]

    Dever, Jennifer A.

    . Cardiovascular Disease III. Chronic Conditions A. Osteoporosis B. Autoimmune conditions C. Alzheimer's Disease-femoral fat þ Hormonal changes may increase a female's appetite þ Menopause is associated with a shift toward

  19. Death signaling 1. Wang, X. The expanding role of mitochondria in apoptosis. Genes Dev 15, 2922-2933.

    E-Print Network [OSTI]

    Wu, Hao

    of degenerative disorders such as Alzheimer's disease, ischemic injury from stroke (heart disease), post-menopausal osteoporosis... #12;Two types of DNA fragmentation Detection of DNA fragmentation · By gel electrophoresis

  20. Death signaling 1. Wang, X. The expanding role of mitochondria in apoptosis. Genes Dev 15, 2922-2933.

    E-Print Network [OSTI]

    Wu, Hao

    of degenerative disorders such as Alzheimer's disease, ischemic injury from stroke (heart disease), post-menopausal osteoporosis... Apoptosis-cellular suicide-programmed cell death · `active' (not passive) form of cell death

  1. June 18, 2012 Symposium on Aging

    E-Print Network [OSTI]

    Church, George M.

    , anemia, muscular dystrophy, and diabetes. The reasons for accelerating research into the molecular diseases of aging such as diabetes, cancer, Alzheimer's and heart disease. Today's attendees come not only

  2. Effects of Chronic Nicotine Exposure and Lack of High Affinity Nicotinic Receptors on Cortico-Hippocampal Areas in the Aging Mouse Brain

    E-Print Network [OSTI]

    Huang, Pei-San

    2012-07-16T23:59:59.000Z

    performance. Epidemiology studies show that smoking is negatively correlated with the incidence of Parkinson's disease and Alzheimer's disease. Postmortem research and neuroimaging studies show that loss of nicotinic binding sites in the brain is the major...

  3. Amino acids in the first transmembrane domain affecting function of the extracellular domain of truncated ?4?2 chimeras of the nicotinic acetylcholine receptor 

    E-Print Network [OSTI]

    Galvan, Adri M

    2014-09-08T23:59:59.000Z

    Important neurological and psychiatric diseases, including Alzheimer disease, nicotine addiction, and schizophrenia, are influenced by nicotinic acetylcholine receptors (nAChRs). Understanding the structure and function of nAChRs will provide a...

  4. K. A. Garrett and C. M. Cox. Applied biodiversity science: Managing emerging diseases in agriculture and linked natural systems using 1 ecological principles. Pages 368-386 in Infectious disease ecology: The effects of ecosystems on disease and of disease

    E-Print Network [OSTI]

    Garrett, Karen A.

    in agriculture and linked natural systems using 1 ecological principles. Pages 368-386 in Infectious disease in Agriculture and Linked Natural Systems Using Ecological Principles K. A. Garrett and C. M. Cox Summary particular crop species or genotypes are very common. Nonetheless, production agriculture is dominated

  5. Comparing Online Community Structure of Patients of Chronic Diseases

    E-Print Network [OSTI]

    Maddali, Hanuma Teja; Margolis, Peter

    2015-01-01T23:59:59.000Z

    In this paper we compare the social network structure of people talking about Crohn's disease, Cystic Fibrosis, and Type 1 diabetes on Facebook and Twitter. We find that the Crohn's community's contributors are most emotional on Facebook and Twitter and most negative on Twitter, while the T1D community's communication network structure is most cohesive.

  6. Review article Aujeszky's disease virus: opportunities and challenges

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Review article Aujeszky's disease virus: opportunities and challenges Federico A. ZUCKERMANN les réponses immunitaires humorale et cellulaire chez le porc ont été mises en évidence. Cet article infection in swine similar to that of herpes simplex virus (HSV) in man. ADV is a neuroinvasive virus

  7. PUBLICATION 600-080 Fish Health and Disease

    E-Print Network [OSTI]

    Liskiewicz, Maciej

    PUBLICATION 600-080 Fish Health and Disease Striped bass (Morone saxitilis) and hybrid striped bass these fish are commonly raised in high densities under intensive aquaculture situations (e.g., cages, ponds of the viral, bacterial, fungal, and parasitic pathogens, but the fish become increasingly susceptible

  8. What college students should know about Meningococcal Disease

    E-Print Network [OSTI]

    Wisconsin at Madison, University of

    is relatively rare, occurring at a rate of less than 1 in 100,000 people in the United States. Q. Who is at risk in their throat or nose in a harmless state without developing an illness. Meningococcal bacteria are spread and death within a few hours. Q. How can meningococcal disease be prevented? A. A vaccine is available

  9. Invest in Your Bones Osteoporosis--The Silent Disease

    E-Print Network [OSTI]

    Invest in Your Bones Osteoporosis--The Silent Disease Leaflet 2 Osteoporosis, a painful of State Health Services, 2008). Osteoporosis is preventable and/or treatable. Accordingly, osteoporosis of height, and chronic back pain. Hip fracture, the most serious consequence of osteoporosis, threatens one

  10. Neurobiology of Disease Psychosine Accumulates in Membrane Microdomains in the

    E-Print Network [OSTI]

    Bongarzone, Ernesto R.

    Neurobiology of Disease Psychosine Accumulates in Membrane Microdomains in the Brain of Krabbe of GALC ( -galactosylceramidase) that leads to a progressive accumulation of some galactosyl-sphingolipids in the brain. We hypothesized that the accumulation of psychosine (galactosyl-sphingosine) in the TWI CNS may

  11. Detecting Acromegaly: Screening for Disease with a Morphable Model

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    ridge, and cheek bones. The disease is often missed by physicians and progresses beyond where it might of Blanz and Vetter. The model parameters capture many features of the 3D shape of the subject's head from just a single photograph, and are used directly for classification. We report encouraging results

  12. A Unified Framework for MR Based Disease Classification

    E-Print Network [OSTI]

    Pohl, Kilian M.

    A Unified Framework for MR Based Disease Classification Kilian M. Pohl1,2 and Mert R. Sabuncu2 1-hippocampal gyrus. On this small size data set, our approach, which performs classification based on the MR images with the accuracy achieved by state-of-the-art techniques in schizophrenia MRI research. 1 Introduction Thanks to in

  13. HYGIENIC BEHAVIOR OF HONEY BEES IN RELATION TO CHALKBROOD DISEASE

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    HYGIENIC BEHAVIOR OF HONEY BEES IN RELATION TO CHALKBROOD DISEASE Martha GILLIAM, Stephen TABER III classified as resistant or susceptible on the basis of good or poor hygienic behavior, respectively. Colonies colonies that exhibit poor hygienic behavior. Therefore, good hygienic behavior of bees aids in control

  14. Cerebral blood flow in sickle cell cerebrovascular disease

    SciTech Connect (OSTI)

    Huttenlocher, P.R.; Moohr, J.W.; Johns, L.; Brown, F.D.

    1984-05-01T23:59:59.000Z

    Cerebral blood flow (CBF) has been studied by the xenon-133 (/sup 133/Xe) inhalation method in 16 children with suspected sickle cell cerebrovascular disease. Abnormalities consisting of decreases in total, hemispheral, or regional CBF were found in 17 of 26 studies. Eleven studies performed immediately after stroke, transient ischemic attack, or depression of state of alertness showed abnormalities. In addition to confirming regional cerebrovascular insufficiency in children with stroke due to major cerebral artery occlusion, the method detected diffuse decrease in CBF in children with stupor, coma, and seizures who had normal angiographic findings. In contrast, six of seven studies obtained after exchange transfusion or during maintenance on hypertransfusion therapy showed normal findings. The difference between results in patients with acute neurologic disturbances and those receiving transfusion therapy was statistically significant (P less than .005). The data indicate that the /sup 133/Xe method reliably demonstrates cerebrovascular impairment in sickle cell disease. They also suggest that CBF changes in patients with sickle cell disease can be reversed by exchange transfusion and by hypertransfusion therapy. The /sup 133/Xe CBF method may be useful for following up children with sickle cell disease who are at high risk for recurrent stroke.

  15. Botryosphaeriaceae associated with Eucalyptus canker diseases in Colombia

    E-Print Network [OSTI]

    Botryosphaeriaceae associated with Eucalyptus canker diseases in Colombia By C. A. Rodas1,3 , B, Pretoria, 0002, South Africa; 3 Smurfit Carto´n de Colombia, Investigacio´n Forestal, Carrera 3 No. 10-36, Cali, Valle, Colombia. 4 E-mail: bernard.slippers@fabi.up.ac.za (for correspondence) Summary

  16. Cancer is a genetic disease1 . Although environmental

    E-Print Network [OSTI]

    Nowak, Martin A.

    Cancer is a genetic disease1 . Although environmental and other non-genetic factors have roles in many stages of tumorigenesis,it is widely accepted that cancer arises because of mutations in cancer,however,does not suffice to give rise to full-blown cancer.For progression towards malignancyandinvasion

  17. A Predator-Prey Model with Disease Dynamics Chris Flake

    E-Print Network [OSTI]

    Logan, David

    a diseased fish population and their predators. Analysis of the system is performed to determine among the Tilapia fish of the Salton Sea and their predator, the pelican. This model is of interest deaths not only among the fish themselves, but also in the pelican population. Studies have indicated

  18. Rapid communication Identification of a Crohn's disease specific

    E-Print Network [OSTI]

    Perreault, Jean-Pierre

    to be due to a combination of factors involving diet, genetic background, immunological responses presented antigen, in individuals with a particular genetic back- ground may be involved in the lack that of their respective proteins appear to be useful as specific markers for unequivocally distinguishing Crohn's disease

  19. Selection of a multiple disease resistant runner-type peanut

    E-Print Network [OSTI]

    Baring, Michael Robert

    2007-09-17T23:59:59.000Z

    Four F2:4 populations of peanut (Arachis hypogaea L.) resulting from the complex cross Tamrun 96 X Tx901639-3 X Sun Oleic 95R were grown in three disease nurseries over a 2 year period. Three separate selection techniques were applied to determine...

  20. Introduction The number of catalogued emerging infectious diseases (EIDs), and

    E-Print Network [OSTI]

    Sehgal, Ravinder

    ). Perhaps even more immediate than these other factors are the implications of large- scale deforestation on disease emergence. The global rate of tropical deforestation appears to be increasing readily; between of deforestation in parts of Africa are near 1% per year (FAO, 2009). Deforestation is also increasing in temperate

  1. Food, Poverty and Epidemic Disease, Edinburgh: 1840-1850 

    E-Print Network [OSTI]

    MacGillivray, Neil

    2004-01-01T23:59:59.000Z

    epidemic disease is studied, concentrating on the fever epidemics of 184 1- 44, 1847-49 and the cholera outbreak of 1848-49 but reviewing also the lesser epidemics of measles, whooping cough and scarlet fever. The history of the identification of typhus...

  2. Prediction and Informative Risk Factor Selection of Bone Diseases

    E-Print Network [OSTI]

    Zhang, Aidong

    data and use these integrated features to effectively predict osteoporosis and bone fractures. We; disease memory; osteoporosis; bone fracture. ! 1 INTRODUCTION Risk factor (RF) analysis based on patients on the study of osteoporosis and bone fracture prediction. Over the past few decades, osteoporosis has been

  3. Random Disease on the Square Grid J ozsef Balogh

    E-Print Network [OSTI]

    Balogh, Jozsef

    a disease process. The initial configuration is called contagious or successful if the corresponding) squares in a contagious configuration. The solution of the initial exercise is the following: Fact. [Folklore] G(n) = n. Proof. If we paint the squares of a diagonal black, it will be a contagious

  4. Structural Location of Disease-associated Single-nucleotide Polymorphisms

    E-Print Network [OSTI]

    Pervouchine, Dmitri D.

    Structural Location of Disease-associated Single-nucleotide Polymorphisms Nathan O. Stitziel1 , Yan-synonymous single-nucleotide polymorphism (nsSNP) of genes introduces amino acid changes to proteins, and plays reserved Keywords: single-nucleotide polymorphism; alpha shape; hidden Markov model; surface pockets

  5. National Center for Immunization and Respiratory Diseases No More Excuses

    E-Print Network [OSTI]

    Liblit, Ben

    to protect yourself and your family. If you miss getting your flu vaccine in the fall, make it a New Year Vaccine WrongThe flu (influenza) is a contagious disease which affects the lungs and can lead to serious protect against non-flu viruses. · Oryoumighthavebeenexposedtoflu after you got vaccinated but before

  6. Prevalence of chronic obstructive pulmonary disease in rural women of

    E-Print Network [OSTI]

    Silver, Whendee

    for refining disease burden assessments attributable to household biomass combustion Priscilla Johnson1 January and May 2007. COPD assessments were done using a combination of clinical examination spend !2 hours/day in the kitchen involved in cooking. Use of solid fuel was associated with higher risk

  7. AT A GLANCE....INSECTS AND DISEASE PROBLEMS THAT SHOULD BE CONSIDERED THIS PEST/DISEASE/CULTURE

    E-Print Network [OSTI]

    Goodman, Robert M.

    /DISEASE/CULTURE JULY 8- JULY 15 HARVEST JULY 15- JULY 22 HARVEST SPOTTED WING DROSOPHILA Lannate, Imidan, Malathion effective against aphids and maggot when possible. Monitor with traps, and use materials that are also effective against aphids and maggot when possible. BLUEBERRY MAGGOT See list from previous newsletter

  8. Unusual thoracic radiographic findings in children treated for Hodgkin's disease

    SciTech Connect (OSTI)

    Jochelson, M.S.; Tarbell, N.J.; Weinstein, H.J.

    1986-06-01T23:59:59.000Z

    Mantle irradiation is often part of the treatment for Hodgkin's disease. Localized pneumonitis and fibrosis are well-known sequelae of this treatment. We report nine patients with unusual thoracic radiographic findings following treatment for Hodgkin's disease. All nine had mediastinal widening. Seven of these patients received combined modality therapy in which prednisone was given with their MOPP. In these seven patients, an increase in mediastinal width developed at the same time as the radiographic changes of radiation pneumonitis. Two patients developed bilateral infiltrates extending beyond the field of radiation to the lung periphery. In one of these patients, a spontaneous pneumomediastinum developed. One patient underwent mediastinal biopsy that revealed inflammatory changes similar to those seen in radiation pneumonitis. All patients either responded to steroids or had spontaneous regression of radiographic abnormalities supporting the presumed diagnosis of treatment related changes. Recognition of these unusual sequelae of mantle irradiation will aid in differentiating them from infection or tumor and lead to prompt, appropriate treatment.

  9. Programming of cardiovascular disease across the life-course

    E-Print Network [OSTI]

    Blackmore, Heather L.; Ozanne, Susan E.

    2014-12-12T23:59:59.000Z

    is critical in defining an individual’s risk in later life. Left unresolved sub- clinical conditions manifest into diseases such as atherosclerosis, myocardial infarction, stroke and heart failure. Although adverse lifestyle choices in adulthood (poor diet... ]. Maternal protein restriction is one of the most widely studied models of maternal undernutrition and similarly to global caloric restriction, offspring of protein-restricted dams have been shown to have high blood pressure in adulthood [36-39]. However...

  10. I N T H I S I S S U E Lyme disease communication

    E-Print Network [OSTI]

    I N T H I S I S S U E · Lyme disease communication to countryside users · Providing public benefits in private woodlands, causes of wildfires in South Wales and communicating animal disease (Lyme) risks

  11. Morphological, cellular and proteomic features of canine myxomatous mitral valve disease 

    E-Print Network [OSTI]

    Han, Richard I-Ming

    2009-01-01T23:59:59.000Z

    Myxomatous mitral valve degeneration (MMVD) is the single most common cardiac disease of the dog, and is analogous to Mitral Valve Prolapse in humans. Very little is known about the aetiopathogenesis of this disease or ...

  12. Design of a numerical model for simulation of blood microcirculation and study of sickle cell disease

    E-Print Network [OSTI]

    Le Floch-Yin, François T. (François Thomas)

    2010-01-01T23:59:59.000Z

    Sickle cell disease is nowadays one of the most challenging blood diseases, where patients suffer from both chronic and acute episodes of painful medical conditions. In particular, unpredictable crises due to blood vessel ...

  13. A common allele on chromosome 9 associated with coronary heart disease

    E-Print Network [OSTI]

    2007-01-01T23:59:59.000Z

    M. Appleyard, European Heart Journal 3, Suppl H. , H1 (associated with Coronary Heart Disease in whites. Minor9 associated with coronary heart disease Ruth McPherson 1* ,

  14. Correlation of Klebsiella pneumoniae Comparative Genetic Analyses with Virulence Profiles in a Murine Respiratory Disease Model

    E-Print Network [OSTI]

    Fodah, Ramy A.

    Klebsiella pneumoniae is a bacterial pathogen of worldwide importance and a significant contributor to multiple disease presentations associated with both nosocomial and community acquired disease. ATCC 43816 is a well-studied ...

  15. Fluid and structural modeling of the disease-free and atherosclerotic human carotid bifurcation

    E-Print Network [OSTI]

    Younis, Hesham F. (Hesham Farouk)

    2002-01-01T23:59:59.000Z

    Cardiovascular disease is the leading cause of death in the United States. It claims more lives each year than the next 7 leading causes of death combined. Atherosclerosis is a major cause of cardiovascular disease and is ...

  16. Integrated training in Cardiovascular Diseases Sponsored by the Division of Cardiology

    E-Print Network [OSTI]

    Gleeson, Joseph G.

    and interventional procedures such as percutaneous interventions such as angioplasty and stent placement Knowlton, Division Head I. Major Diseases 1. Coronary artery disease 2. Congestive Heart Failure 3. Cardiac

  17. Di#erential equation models for Aujeszky's Disease Virus (ADV) in Irish pig herds

    E-Print Network [OSTI]

    , Dublin City University, Dublin 9, Ireland Abstract Aujeszky's Disease virus, (ADV) is a contagious viral Aladar Aujeszky, when he distinguished psuedorabies from rabies [23]. Aujeszky's Disease is a contagious

  18. Micro-Simulations of Infectious Disease using Official Register Data The Case of Smallpox

    E-Print Network [OSTI]

    Boman, Magnus

    , for example. #12;Introduction Should an infection of a contagious disease occur, the potential threat must be seen as an example of a predominantly airborne, fairly contagious vaccine-preventable disease where

  19. Differential equation models for Aujeszky's Disease Virus (ADV) in Irish pig herds

    E-Print Network [OSTI]

    ) is a contagious viral disease that affects the cen- tral nervous system of almost all animals, but swine are its Aladar Aujeszky, when he distinguished psuedorabies from rabies [23]. Aujeszky's Disease is a contagious

  20. asian foot-and-mouth disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Physics Websites Summary: Modelling the spread of foot-and-mouth disease virus F Moutou B Durand CNEVA, Laboratoire Central-and-mouth disease is an economically important viral...

  1. attenuated foot-and-mouth disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Physics Websites Summary: Modelling the spread of foot-and-mouth disease virus F Moutou B Durand CNEVA, Laboratoire Central-and-mouth disease is an economically important viral...

  2. assess foot-and-mouth disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Physics Websites Summary: Modelling the spread of foot-and-mouth disease virus F Moutou B Durand CNEVA, Laboratoire Central-and-mouth disease is an economically important viral...

  3. Three surveillance systems for describing the spatial distribution of Johne's disease seropositivity in Texas cattle

    E-Print Network [OSTI]

    Pearce, Brielle H.

    2009-05-15T23:59:59.000Z

    distribution of Johne’s disease seropositvity, based on the three surveillance systems, confirmed our hypothesis that estimation of disease distribution is dependant upon the source of surveillance samples....

  4. Pharmacological Chaperone Design for Reducing Risk Factor of Parkinson’s Disease from Traditional Chinese Medicine

    E-Print Network [OSTI]

    Huang, Hung-Jin

    Dysfunction of ?-glucocerebrosidase (GCase) has no hydrolytic activity in patients of Gaucher's disease and increasing the risk factor for Parkinson’s disease occurrence. Pharmacological chaperone design has been used to ...

  5. Point-of-care diagnostics for noncommunicable diseases using synthetic urinary biomarkers and paper microfluidics

    E-Print Network [OSTI]

    Warren, Andrew David

    With noncommunicable diseases (NCDs) now constituting the majority of global mortality, there is a growing need for low-cost, noninvasive methods to diagnose and treat this class of diseases, especially in resource-limited ...

  6. Ann Occup Hyg . Author manuscript Asbestos-related diseases in automobile mechanics

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Ann Occup Hyg . Author manuscript Page /1 7 Asbestos-related diseases in automobile mechanics Abstract Purpose Automobile mechanics have been exposed to asbestos number of automobile mechanics, little is known about the non-malignant respiratory diseases observed

  7. Research Summary Assessing and communicating animal disease risks for countryside users

    E-Print Network [OSTI]

    to the collection of available leaflets on Lyme disease and to analyse their content mco-supervise a RELU Ph

  8. Proposed measures for the control of three diseases of veterinary public health significance in Bolivia

    E-Print Network [OSTI]

    Justiniano, Mario Miguel

    1981-01-01T23:59:59.000Z

    designed to suppress or eradicate disease has been presented. Plans for the development of effective programs for control of foot-and-mouth disease, brucellosis, and rabies have been presented along with recom- mendations for utilizing a task force... manuscripts of my thesis. TABLE OF CONTENTS Page INTRODUCTION. REVIEW OF THE LITERATURE. Geography Topography. Demography. Livestock Production. 10 Foot-and-Mouth Disease. Veterinary Public Health Aspects of Foot-and-Mouth Disease. 12 Control...

  9. Cardiovascular Disease and Functional Foods: The Effect of Milk Derived Peptides on Hypertension

    E-Print Network [OSTI]

    Nottingham, University of

    1 Cardiovascular Disease and Functional Foods: The Effect of Milk Derived Peptides on Hypertension and Hypertension Cardiovascular disease (CVD) encompasses many conditions including coronary heart disease, heart attack (myocardial infarction), stroke and hypertension. In 2003, CVD accounted for 16.7 million

  10. "Red Sore Disease"in Game Fish1 Peggy Reed and Ruth Francis-Floyd2

    E-Print Network [OSTI]

    Watson, Craig A.

    VM85 "Red Sore Disease"in Game Fish1 Peggy Reed and Ruth Francis-Floyd2 1. This document is VM85 fish is generically referred to as "red sore disease." This problem usually occurs in the spring on their fish. Typically, "red sore disease" is caused by two organisms, Aeromonas hydrophila , a bacterium

  11. Arsenic exposure from drinking water and mortality from cardiovascular disease in Bangladesh: prospective cohort

    E-Print Network [OSTI]

    van Geen, Alexander

    13 million residents in the United States.1 Although the International Agency for Research on Cancer Death from cardiovascular disease. Results 198 people died from diseases of circulatory system, accounting for 43% of total mortality in the population. The mortality rate for cardiovascular disease

  12. Machine Learning Algorithms for Predicting Severe Crises of Sickle Cell Disease

    E-Print Network [OSTI]

    Emilion, Richard

    thalassemia, another inherited anemia). The eects of sickle cell disease vary greatly from one personMachine Learning Algorithms for Predicting Severe Crises of Sickle Cell Disease Clara Allayous of an acute splenic sequestration crisis (ASSC), a serious symptom of sickle cell disease (SCD). Precisely

  13. THe heartTruTH Heart disease is the #1 killer of

    E-Print Network [OSTI]

    Baker, Chris I.

    THe heartTruTH® #12;Heart disease is the #1 killer of women, but many women do not know they are at risk. The Heart Truth® campaign aims to give women a personal and urgent wake-up call about their risk of heart disease. The red Dress® is the national symbol for women and heart disease awareness introduced

  14. Cost-Sensitive Risk Stratification in the Diagnosis of Heart Disease

    E-Print Network [OSTI]

    Carbonell, Jaime

    Cost-Sensitive Risk Stratification in the Diagnosis of Heart Disease Selen Uguroglu and Jaime Pittsburgh, PA 15212 Abstract We investigate machine learning methods for diagnos- tic screening of heart disease. Coronary heart disease is the leading cause of death in the US, causing more deaths than all

  15. Checklist of Successful Health Plan Approaches to Heart Disease and Stroke Prevention

    E-Print Network [OSTI]

    Checklist of Successful Health Plan Approaches to Heart Disease and Stroke Prevention Yes at risk for heart disease, stroke, and related conditions and risk factors (e.g., routine screenings the health plan offer specialized disease management programs for members who have been diagnosed with heart

  16. Heart . Author manuscript Effects of depressive symptoms and coronary heart disease and their

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Heart . Author manuscript Page /1 11 Effects of depressive symptoms and coronary heart disease separately in patients with coronary heart disease (CHD) and in populations healthy at study inception and CHD status. OBJECTIVE To examine effects of depressive symptoms and coronary heart disease

  17. The Diet-Heart Hypothesis: a critical appraisal of the relationship between diet and coronary artery disease

    E-Print Network [OSTI]

    Jurewitz, Daniel L

    2007-01-01T23:59:59.000Z

    for Prevention of Coronary Heart Disease. JAMA. 2002;288:M. Fish consumption and coronary heart disease mortality: aacid and risk of ischemic heart disease among women. Am J

  18. Congestive heart failure: treat the disease, not the symptom: return to normalcy/Part II--the experimental approach.

    E-Print Network [OSTI]

    Buckberg, Gerald D

    2007-01-01T23:59:59.000Z

    Title: Congestive heart failure: treat the disease not theTITLE: Congestive heart failure: treat the disease not theGD. Congestive heart failure: treat the disease, not the

  19. Loss of Hsp70 Exacerbates Pathogenesis But Not Levels of Fibrillar Aggregates in a Mouse Model of Huntington's Disease

    E-Print Network [OSTI]

    Lindquist, Susan

    Endogenous protein quality control machinery has long been suspected of influencing the onset and progression of neurodegenerative diseases characterized by accumulation of misfolded proteins. Huntington's disease (HD) ...

  20. Clifton folio Arizona 

    E-Print Network [OSTI]

    Lindgren, Waldemar, 1860-1939.

    1905-01-01T23:59:59.000Z

    years of the Alzheimer?s disease amyloid hypothesis: A genetic perspective. Cell 120:545-555 Thinakaran G, Koo EH (2008) Amyloid precursor protein trafficking, processing, and function. Biol Chem 283: 29615-29619. Turr?-Garriga O, L?pez-Pousa S...

  1. A Table of Areas Under Disease Progress Curves. 

    E-Print Network [OSTI]

    Johnson, Dennis A.; Wilcoxson, Roy D.

    1980-01-01T23:59:59.000Z

    [Blank Page in Original Bulletin] A TABLE OF AREAS UNDER DISEASE PROGRESS CURVES Technical Bullet in Texas Agricultural Experiment Station Texas A & M University System- [Blank Page in Original Bulletin] A TABLE OF AREAS UNDER D I S E A S E... Chillicothe-Vernon, TX 76384; and Professor Department of Plant Pathology University of Minnesota St. Paul, MN 55108 A T a b l e o f A r e a s Under D i s e a s e P r o g r e s s Curves 3 Denn i s A. J o h n s o n and Roy D . \\ W i l c o x s o...

  2. Sorghum Ergot: New Disease Threat to the Sorghum Industry

    E-Print Network [OSTI]

    Krausz, Joseph P.; Isakeit, Thomas

    1998-07-20T23:59:59.000Z

    of the sorghum ergot pathogen and likely serves as an overwintering source of ergot inoculum in south Texas. E-461 6-98 Sorghum Ergot New Disease Threat to the Sorghum Industry *Extension Plant Pathologists, The Texas A&M University System. Newly formed honeydew... dripping from an infected panicle. Joseph Krausz and Thomas Isakeit* Ho w is it a Threat to Texas? Each f_lo wer infected with ergot represents a direct loss of one seed. Additional losses occur because the stickiness of infected panicles inter- feres...

  3. Commercial Pecans: Controlling Rosette, Diseases and Zinc Deficiency

    E-Print Network [OSTI]

    Lee, Thomas A.; Krausz, Joseph P.

    2006-04-13T23:59:59.000Z

    Company Rate/acre Diseases Remarks Abound Azoxystrobin Syngenta 6.21?2.3 oz Scab, anthracnose Maximum 1.16 qt/year. No more than 3 applications before switching fungicides. 7?21-day interval Sovran Kresoxim-methyl BASF Pre... 30 oz/season. Trifl oxystrobin No more than 3 applications at a time before alternating. 14- to 21-day interval Headline Pyraclostrobin BASF 6?7 oz/A Scab Maximum 4 applications/ season or max of 28 oz/ season...

  4. Development of Biomarkers for Chronic Beryllium Disease in Mice

    SciTech Connect (OSTI)

    Gordon, Terry

    2013-01-25T23:59:59.000Z

    Beryllium is a strategic metal, indispensable for national defense programs in aerospace, telecommunications, electronics, and weaponry. Exposure to beryllium is an extensively documented occupational hazard that causes irreversible, debilitating granulomatous lung disease in as much as 3 - 5% of exposed workers. Mechanistic research on beryllium exposure-disease relationships has been severely limited by a general lack of a sufficient CBD animal model. We have now developed and tested an animal model which can be used for dissecting dose-response relationships and pathogenic mechanisms and for testing new diagnostic and treatment paradigms. We have created 3 strains of transgenic mice in which the human antigen-presenting moiety, HLA-DP, was inserted into the mouse genome. Each mouse strain contains HLA-DPB1 alleles that confer different magnitude of risk for chronic beryllium disease (CBD): HLA-DPB1*0401 (odds ratio = 0.2), HLA-DPB1*0201 (odds ratio = 15), HLA-DPB1*1701 (odds ratio = 240). Our preliminary work has demonstrated that the *1701 allele, as predicted by human studies, results in the greatest degree of sensitization in a mouse ear swelling test. We have also completed dose-response experiments examining beryllium-induced lung granulomas and identified susceptible and resistant inbred strains of mice (without the human transgenes) as well as quantitative trait loci that may contain gene(s) that modify the immune response to beryllium. In this grant application, we propose to use the transgenic and Â?normal inbred strains of mice to identify biomarkers for the progression of beryllium sensitization and CBD. To achieve this goal, we propose to compare the sensitivity and accuracy of the lymphocyte proliferation test (blood and bronchoalveolar lavage fluid) with the ELISPOT test in the three HLA-DP transgenic mice strains throughout a 6 month treatment with beryllium particles. Because of the availability of high-throughput proteomics, we will also identify changes in potential protein biomarkers in beryllium-treated mice. We will correlate these findings with the ability of the transgenic mice to develop a beryllium-specific adaptive immune response in blood and bronchoalveolar lavage (BAL) fluid. We will also determine whether beryllium-responsive CD4+ T cells in blood and BAL correlate with the onset of granuloma formation. Thus, we will provide the scientific community with biomarkers of sensitization and disease progression for CBD. These biomarkers will serve as critical tools for development of improved industrial hygiene and therapeutic interventions.

  5. Chronic Beryllium Disease Prevention Program (10 CFR 850) | Department of

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011AT&T, Inc.'sEnergyTexas1. Feedstock &Energy Chronic Beryllium Disease

  6. Heart DiseaseHeart Disease--Learn to Love YourLearn to Love Your Michael McKee, M.D.Michael McKee, M.D.

    E-Print Network [OSTI]

    Goldman, Steven A.

    Heart DiseaseHeart Disease-- Learn to Love YourLearn to Love Your HeartHeart Michael McKee, M.D.Michael McKee, M.D. March 19, 2010March 19, 2010 #12;GoalsGoals ·· Learn more about heart disease for yourself andLearn more about heart disease for yourself and for your studentsfor your students ·· Learn

  7. ULTRASTRUCTURAL FEATURES OF CHROMATIN ~, BODIES ADA L. OLINS, MARILYN B. SENIOR, and DONALD E. OLINS. From the University of Tennessee-

    E-Print Network [OSTI]

    Olins, Ada L.

    (18). Dissociation of the histones and DNA was accomplished by overnight dialysis of nucleohistone (A2,0M MgCis, 10 mM Tris (pH 7.4), and 0.5% Nonidet P-40 (Particle Data Inc., Elm- hurst, Ill.). Nuclei

  8. Data:08c71545-a256-4e92-ada2-ef5568659916 | Open Energy Information

    Open Energy Info (EERE)

    Sector: Commercial Description: RULES AND REGULATIONS: Terms and conditions of this electric rate schedule and the General Rules and Regulations govern use of this service....

  9. Data:67840de4-3847-44f1-bfe8-ada958568a98 | Open Energy Information

    Open Energy Info (EERE)

    Utility name: City of Elizabethton, Tennessee (Utility Company) Effective date: 20131201 End date if known: Rate name: General Power - Schedule GSA 3 Sector: Commercial...

  10. Published in 2000 In M. Mifsud (ed.) Proceedings of the Third International Conference Ada Malta 29 March-2 April

    E-Print Network [OSTI]

    Boyer, Edmond

    Published in 2000 In M. Mifsud (ed.) Proceedings of the Third International Conference Aïda Malta Author manuscript, published in "Third International Conference of Aïda, Malta : Malta (2000)" #12;status

  11. Bead-based microfluidic immunoassay for diagnosis of Johne's disease

    SciTech Connect (OSTI)

    Wadhwa, Ashutosh [University of Tennessee, Center for Wildlife Health, Department of Forestry; Foote, Robert [ORNL; Shaw, Robert W [ORNL; Eda, Shigetoshi [ORNL

    2012-01-01T23:59:59.000Z

    Microfluidics technology offers a platform for development of point-of-care diagnostic devices for various infectious diseases. In this study, we examined whether serodiagnosis of Johne s disease (JD) can be conducted in a bead-based microfluidic assay system. Magnetic micro-beads were coated with antigens of the causative agent of JD, Mycobacterium avium subsp. paratuberculosis. The antigen-coated beads were incubated with serum samples of JD-positive or negative serum samples and then with a fluorescently-labeled secondary antibody (SAB). To confirm binding of serum antibodies to the antigen, the beads were subjected to flow cytometric analysis. Different conditions (dilutions of serum and SAB, types of SAB, and types of magnetic beads) were optimized for a great degree of differentiation between the JD-negative and JD-positive samples. Using the optimized conditions, we tested a well-classified set of 155 serum samples from JD negative and JD-positive cattle by using the bead-based flow cytometric assay. Of 105 JD-positive samples, 63 samples (60%) showed higher antibody binding levels than a cut-off value determined by using antibody binding levels of JD-negative samples. In contrast, only 43-49 JD-positive samples showed higher antibody binding levels than the cut-off value when the samples were tested by commercially-available immunoassays. Microfluidic assays were performed by magnetically immobilizing a number of beads within a microchannel of a glass microchip and detecting antibody on the collected beads by laser-induced fluorescence. Antigen-coated magnetic beads treated with bovine serum sample and fluorescently-labeled SAB were loaded into a microchannel to measure the fluorescence (reflecting level of antibody binding) on the beads in the microfluidic system. When the results of five bovine serum samples obtained with the system were compared to those obtained with the flow cytometer, a high level of correlation (linear regression, r2 = 0.994) was observed. In a further experiment, we magnetically immobilized antigen-coated beads in a microchannel, reacted the beads with serum and SAB in the channel, and detected antibody binding to the beads in the microfluidic system. A strong antibody binding in JD-positive serum was detected, whereas there was only negligible binding in negative control experiments. Our data suggest that the bead-based microfluidic system may form a basis for development of an on-site serodiagnosis of JD. Key Words: Mycobacterium avium ssp. paratuberculosis, Johne s disease, microfluidics, lab-on-a-chip.

  12. Bisphosphonates and Bone diseases: past, present and future Bisphosphonates are stable analogues of the naturally-occuring inorganic

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    involving excessive bone resorption which include post-menopausal osteoporosis, Paget's disease of bone

  13. When you hear the term "heart disease," what's your first reaction? Like many women, you may think, "That's a

    E-Print Network [OSTI]

    Bandettini, Peter A.

    When you hear the term "heart disease," what's your first reaction? Like many women, you may think, "That's a man's disease." But here's The Heart Truth: Heart disease is the #1 killer of Latinas in the United States. Together with stroke, heart disease accounts for a third of all deaths among Latinas

  14. When you hear the term "heart disease," what is your first reaction? Like many women, you may think, "That's a

    E-Print Network [OSTI]

    Bandettini, Peter A.

    When you hear the term "heart disease," what is your first reaction? Like many women, you may think, "That's a man's disease." But here's The Heart Truth: Heart disease is the #1 killer of women in the United States. It is also a leading cause of disability among women. If you've got a heart, heart disease

  15. A Table of Areas Under Disease Progress Curves.

    E-Print Network [OSTI]

    Johnson, Dennis A.; Wilcoxson, Roy D.

    1980-01-01T23:59:59.000Z

    o n s d a r i n g t h e development o f t h e ep idemic . The v a l u e s f o r AUDPC a r e l i s t e d under t h e days between t h e o b s e r v a t i o n s o f d i s e a s e . Thus , from d i s e a s e s e v e r i t i e s t a... a i d o f t h e m o d i f i e d c o b b Scale (12). The rus t sever i tyda tawere converted Fig. 2 Disease Progress Curves of Three Winter Wheat Cultivars Infected with Puccinia recondita f. sp. tritici. - TAM W-101 - - - I 1 A 0 ~ i m e...

  16. Ulcerative colitis and steroid-responsive, diffuse interstitial lung disease

    SciTech Connect (OSTI)

    Balestra, D.J.; Balestra, S.T.; Wasson, J.H.

    1988-07-01T23:59:59.000Z

    The authors describe a patient with ulcerative colitis and extracolonic manifestations in whom diffuse interstitial pulmonary disease developed that was responsive to glucocorticoid therapy one year after total proctocolectomy. The patient presented in December 1983 with a subacute course marked by cough and progressive exertional dyspnea, abnormal chest examination results, and a chest roentgenogram that revealed diffuse interstitital and alveolar infiltrates. A transbronchial biopsy specimen revealed a polymorphic interstitial infiltrate, mild interstitial fibrosis without apparent intraluminal fibrosis, and no vasculitis, granulomas, or significant eosinophilic infiltration. Within one week of the initiation of daily high-dose steroid therapy, the patient's symptoms dramatically improved; chest roentgenogram and forced vital capacity (60%) improved at a slower rate. All three measures deteriorated when alternate-day prednisone therapy was started but once again improved until the patient was totally asymptomatic, chest roentgenograms were normal, and forced vital capacity was 80% of the predicted value 2 1/2 years later.

  17. Neurological Complications Following Endoluminal Repair of Thoracic Aortic Disease

    SciTech Connect (OSTI)

    Morales, J. P.; Taylor, P. R.; Bell, R. E.; Chan, Y. C. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Vascular Surgery (United Kingdom); Sabharwal, T. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Interventional Radiology (United Kingdom); Carrell, T. W. G. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Vascular Surgery (United Kingdom); Reidy, J. F. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Interventional Radiology (United Kingdom)], E-mail: John.Reidy@gstt.nhs.uk

    2007-09-15T23:59:59.000Z

    Open surgery for thoracic aortic disease is associated with significant morbidity and the reported rates for paraplegia and stroke are 3%-19% and 6%-11%, respectively. Spinal cord ischemia and stroke have also been reported following endoluminal repair. This study reviews the incidence of paraplegia and stroke in a series of 186 patients treated with thoracic stent grafts. From July 1997 to September 2006, 186 patients (125 men) underwent endoluminal repair of thoracic aortic pathology. Mean age was 71 years (range, 17-90 years). One hundred twenty-eight patients were treated electively and 58 patients had urgent procedures. Anesthesia was epidural in 131, general in 50, and local in 5 patients. Seven patients developed paraplegia (3.8%; two urgent and five elective). All occurred in-hospital apart from one associated with severe hypotension after a myocardial infarction at 3 weeks. Four of these recovered with cerebrospinal fluid (CSF) drainage. One patient with paraplegia died and two had permanent neurological deficit. The rate of permanent paraplegia and death was 1.6%. There were seven strokes (3.8%; four urgent and three elective). Three patients made a complete recovery, one had permanent expressive dysphasia, and three died. The rate of permanent stroke and death was 2.1%. Endoluminal treatment of thoracic aortic disease is an attractive alternative to open surgery; however, there is still a risk of paraplegia and stroke. Permanent neurological deficits and death occurred in 3.7% of the patients in this series. We conclude that prompt recognition of paraplegia and immediate insertion of a CSF drain can be an effective way of recovering spinal cord function and improving the prognosis.

  18. Dual-Energy CT Angiography in Peripheral Arterial Occlusive Disease

    SciTech Connect (OSTI)

    Brockmann, Carolin, E-mail: carolin.brockmann@rad.ma.uni-heidelberg.de; Jochum, Susanne; Sadick, Maliha [University of Heidelberg, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim (Germany); Huck, Kurt [University of Heidelberg, I. Medical Clinic, Medical Faculty Mannheim (Germany); Ziegler, Peter [University of Heidelberg, Department of Surgery, Medical Faculty Mannheim (Germany); Fink, Christian; Schoenberg, Stefan O.; Diehl, Steffen J. [University of Heidelberg, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim (Germany)

    2009-07-15T23:59:59.000Z

    We sought to study the accuracy of dual-energy computed tomographic angiography (DE-CTA) for the assessment of symptomatic peripheral arterial occlusive disease of the lower extremity by using the dual-energy bone removal technique compared with a commercially available conventional bone removal tool. Twenty patients underwent selective digital subtraction angiography and DE-CTA of the pelvis and lower extremities. CTA data were postprocessed with two different applications: conventional bone removal and dual-energy bone removal. All data were reconstructed and evaluated as 3D maximum-intensity projections. Time requirements for reconstruction were documented. Sensitivity, specificity, accuracy, and concordance of DE-CTA regarding degree of stenosis and vessel wall calcification were calculated. A total of 359 vascular segments were analyzed. Compared with digital subtraction angiography, sensitivity, specificity, and accuracy, respectively, of CTA was 97.2%, 94.1%, and 94.7% by the dual-energy bone removal technique. The conventional bone removal tool delivered a sensitivity of 77.1%, a specificity of 70.7%, and an accuracy of 72.0%. Best results for both postprocessing methods were achieved in the vascular segments of the upper leg. In severely calcified segments, sensitivity, specificity, and accuracy stayed above 90% by the dual-energy bone removal technique, whereas the conventional bone removal technique showed a substantial decrease of sensitivity, specificity, and accuracy. DE-CTA is a feasible and accurate diagnostic method in the assessment of symptomatic peripheral arterial occlusive disease. Results obtained by DE-CTA are superior to the conventional bone removal technique and less dependent on vessel wall calcifications.

  19. Standardization of a Pan-Specific Test for the Diagnosis of Lyme Disease in Veterinary Medicine 

    E-Print Network [OSTI]

    Mcgregor, Erin 1990-

    2012-04-30T23:59:59.000Z

    for the designation as UNDERGRADUATE RESEARCH SCHOLAR A Senior Scholars Thesis by ERIN MCGREGOR STANDARDIZATION OF A PAN-SPECIFIC TEST FOR THE DIAGNOSIS OF LYME DISEASE IN VETERINARY MEDICINE Approved by: Research Advisor: Maria... of Veterinary Medicine and Biomedical Sciences Texas A&M University Research Advisor: Dr. Maria Esteve-Gassent Department of Veterinary Pathobiology Lyme disease (LD) is the most prevalent tick borne disease in the US with a total of 22,572 confirmed...

  20. Characterization of the Meq oncoproteins of Marek's disease virus vaccine strain CVI988/Rispens

    E-Print Network [OSTI]

    Ajithdoss, Dharani K.

    2010-07-14T23:59:59.000Z

    the condition in four adult male chickens in 1907 (Biggs, 1961; Marek, 1907). He described the disease as a "polyneuritis" or a ?neuritis interstitialis?, characterized by paralysis of the legs and wings. Grossly, the sacral plexuses and spinal cords were... leukosis virus (Biggs, 1961; Campbel, 1961; Elermann, 1922). Based on susceptibility, organs afected, and histopathogenesis, the disease can be distinguished from lymphoid leucosis and a new name, Marek?s disease, was proposed (Biggs, 1961). Later...

  1. E-Print Network 3.0 - aggravated creutzfeldt-jacob disease Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Proteins are the workhorses of the body, and the enigmatic process... secrets of protein folding that could lead to improved diagnosis and treatment of diseases Source: Daggett,...

  2. Soil fungicides in relation to cotton seedling disease at various temperature levels

    E-Print Network [OSTI]

    Ranney, Carleton David

    1955-01-01T23:59:59.000Z

    to obtain controlled spacing an4 4epth of seed ?hon ylanting, ~, , ~ 18 Xllnotration of seedling disease grades. Xi No evidence of diseases' energed 2 Sprouted' no e?L'donee of disease; no ssLergenoe. 5 Lesion less than three nao in length? 4i Lesion... of disease. 2, Emerged; lesion lees than three nn. long. ~Eaepgedj le&oh learn Qlall I%a ss, 10$$, gl aineb io the non proprietary nano ef sino ?thglene bi sdithiooarhanate. 4. Knerged~ sevorelF lesiono4, but not girdle4. 5? Energed~ dea4 or girdling...

  3. Relation of aortic valve calcium to chronic kidney disease (from the Chronic Renal Insufficiency Cohort Study)

    E-Print Network [OSTI]

    2015-01-01T23:59:59.000Z

    with calcific aortic valve disease. Cardiovascular HealthA, et al. Cardiac valve calcification in haemodialysisCurtis JR. Aortic and mitral valve calcification in patients

  4. Relation of Aortic Valve Calcium to Chronic Kidney Disease (from the Chronic Renal Insufficiency Cohort Study)

    E-Print Network [OSTI]

    2015-01-01T23:59:59.000Z

    with calcific aortic valve disease. Cardiovascular HealthA, et al. Cardiac valve calcification in haemodialysisCurtis JR. Aortic and mitral valve calcification in patients

  5. Edge effects, not connectivity, determine the incidence and development of a foliar fungal plant disease.

    SciTech Connect (OSTI)

    Johnson, Brenda, L.; Haddad, Nick, M.

    2011-08-01T23:59:59.000Z

    Using a model plant-pathogen system in a large-scale habitat corridor experiment, we found that corridors do not facilitate the movement of wind-dispersed plant pathogens, that connectivity of patches does not enhance levels of foliar fungal plant disease, and that edge effects are the key drivers of plant disease dynamics. Increased spread of infectious disease is often cited as a potential negative effect of habitat corridors used in conservation, but the impacts of corridors on pathogen movement have never been tested empirically. Using sweet corn (Zea mays) and southern corn leaf blight (Cochliobolus heterostrophus) as a model plant-pathogen system, we tested the impacts of connectivity and habitat fragmentation on pathogen movement and disease development at the Savannah River Site, South Carolina, USA. Over time, less edgy patches had higher proportions of diseased plants, and distance of host plants to habitat edges was the greatest determinant of disease development. Variation in average daytime temperatures provided a possible mechanism for these disease patterns. Our results show that worries over the potentially harmful effects of conservation corridors on disease dynamics are misplaced, and that, in a conservation context, many diseases can be better managed by mitigating edge effects.

  6. Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease

    E-Print Network [OSTI]

    2014-01-01T23:59:59.000Z

    Integrative Genomics Reveals Novel Molecular Pathways and7 | e1004502 Integrative Genomics of Coronary Artery Disease2012) Use of functional genomics to identify candidate genes

  7. Peripheral arterial disease and osteoporosis in older adults: the Rancho Bernardo Study

    E-Print Network [OSTI]

    von Mühlen, D.; Allison, M.; Jassal, S. K.; Barrett-Connor, E.

    2009-01-01T23:59:59.000Z

    calcification and the risk of osteoporosis and fractures. Jarterial disease and osteoporosis in older adults: theassociation between PAD and osteoporosis and bone loss only

  8. Development and application of mass spectrometry-based metabolomics methods for disease biomarker identification

    E-Print Network [OSTI]

    Tong, Lily Victoria

    2008-01-01T23:59:59.000Z

    Human societies face diverse health challenges including a rapidly aging population, rising incidence of metabolic disease, and increasing antibiotic resistance. These problems involve complex interactions between genes ...

  9. Modelling of Blood Diseases November 5-9, 2007, Lyon, France

    E-Print Network [OSTI]

    Maume-Deschamps, Véronique

    Workshop Modelling of Blood Diseases November 5-9, 2007, Lyon, France Scientific committee: M (CNRS) Topics: Blood coagulation Hemophilia Leukemia Atherosclerosis Stroke Angiogenesis Plenary

  10. Lymphocystis Disease in Fish1 Roy P. E. Yanong, VMD2

    E-Print Network [OSTI]

    Watson, Craig A.

    FA181 Lymphocystis Disease in Fish1 Roy P. E. Yanong, VMD2 1. This document is FA181, one and marine fishes caused by infection with an iridovirus known as Lymphocystivirus or Lymphocystis disease does not cause significant mortalities, it does cause unsightly growths on fish that reduce

  11. Spatially Regularized Logistic Regression for Disease Mapping on Large Moving Populations

    E-Print Network [OSTI]

    Vucetic, Slobodan

    . Categories and Subject Descriptors H.2.8 [Database Management]: Database Apps--Data Mining General Terms, Movement trajectories, Spatial-temporal data mining, Regularization, Privacy. 1. INTRODUCTION Disease, forestry, ecology, astronomy, and archeology [3]. There are two major methods for disease mapping

  12. Naam: mw. prof. dr. ir. Y.T. van der Schouw Leeropdracht Chronic Disease Epidemiology

    E-Print Network [OSTI]

    Utrecht, Universiteit

    differ between men and women, and how menopause and estrogens might be involved in this risk difference against chronic diseases of aging, such as cardiovascular disease, breast cancer, osteoporosis diabetics have been submitted. The third and most important area is the role of menopause and estrogens

  13. The Factors of Chronic Kidney Disease: Diabetes, Hypertension, Smoking, Drinking, Betelnut Chewing

    E-Print Network [OSTI]

    Chen, Chaur-Chin

    The Factors of Chronic Kidney Disease: Diabetes, Hypertension, Smoking, Drinking, Betelnut Chewing CKD 75 CKD Abstract The risk factors of Chronic Kidney Disease (CKD), including diabetes risk factors in a population-based cohort. Compared with single risk factors, diabetes (odds ratio 1

  14. Patterns of health and disease have undergone dramatic transitions during human history, reflecting social and

    E-Print Network [OSTI]

    Vermont, University of

    of infectious disease and infant mortality decreased, lengthening life expectancy.At the same time,noninfectious chronic disease rose, accounting for a greater share of over- all mortality. Greater water and air dispersed into new habitats by phoresy (i.e.,one organism transporting another), flight, or wind, but human

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    E-Print Network [OSTI]

    Standiford, Richard B.

    expanding root disease centers, in groups of various sizes, and as scattered individuals. Distribution impacts on resource and ecosystem values for a single site. Insofar as possible, the net effect in progressively expanding disease centers, in tree groups of various sizes, and in scattered individuals. One

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    E-Print Network [OSTI]

    Dykman, Mark

    studied in stochastic population dynamics. Spontaneous extinction of species is important alsoSpeeding up disease extinction with a limited amount of vaccine M. Khasin,1 M. I. Dykman,1 and B stable; disease extinction happens at random and requires a large fluctuation, which can come from

  17. The role of phenoloxidase suppression in QX disease outbreaks among Sydney rock oysters

    E-Print Network [OSTI]

    Raftos, David

    disease. Oysters from the same brood stock were harvested from QX prone and QX free growing areas over negative correlation between phenoloxidase activity and the intensity of parasitic infection ( p = 0 prevented effective management of QX disease in endemic areas. Current management regimes rely only

  18. Coronary Heart Disease: Overview #1 Killer in the U.S.

    E-Print Network [OSTI]

    Meagher, Mary

    #12;Coronary Heart Disease: Overview · #1 Killer in the U.S. · Accounts for more than one in five, the vessels that supply the heart · Disease process: coronary atherosclerosis (plagues in artery) involves flow, shortage of oxygen, pain that radiates across the chest and arms Myocardial infarction - heart

  19. Health Alert: Treating acid reflux disease Posted: Feb 6, 2008 03:03 PM CST

    E-Print Network [OSTI]

    Chiao, Jung-Chih

    Treating acid reflux disease Posted: Feb 6, 2008 03:03 PM CST Updated: Feb 6 Jiang Tang. Exciting news for patients like John who want to treat their nagging, reflux symptoms by Logan Smith 2/8/2008WIStv.com Columbia, SC: Health Alert: Treating acid reflux disease URL: http

  20. Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk

    E-Print Network [OSTI]

    Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk (Cervus in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA 2 Case Western Reserve Accepted 1 August 2006 Chronic wasting disease (CWD) of elk (Cervus elaphus nelsoni) and mule deer