Sample records for advanced plant pharmaceuticals

  1. Advanced Plant Pharmaceuticals Inc | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating SolarElectric Coop,SaveWhiskeyEnergyAd-VentaAddison is aAdenaAdrian

  2. Advanced nuclear plant control complex

    DOE Patents [OSTI]

    Scarola, Kenneth (Windsor, CT); Jamison, David S. (Windsor, CT); Manazir, Richard M. (North Canton, CT); Rescorl, Robert L. (Vernon, CT); Harmon, Daryl L. (Enfield, CT)

    1993-01-01T23:59:59.000Z

    An advanced control room complex for a nuclear power plant, including a discrete indicator and alarm system (72) which is nuclear qualified for rapid response to changes in plant parameters and a component control system (64) which together provide a discrete monitoring and control capability at a panel (14-22, 26, 28) in the control room (10). A separate data processing system (70), which need not be nuclear qualified, provides integrated and overview information to the control room and to each panel, through CRTs (84) and a large, overhead integrated process status overview board (24). The discrete indicator and alarm system (72) and the data processing system (70) receive inputs from common plant sensors and validate the sensor outputs to arrive at a representative value of the parameter for use by the operator during both normal and accident conditions, thereby avoiding the need for him to assimilate data from each sensor individually. The integrated process status board (24) is at the apex of an information hierarchy that extends through four levels and provides access at each panel to the full display hierarchy. The control room panels are preferably of a modular construction, permitting the definition of inputs and outputs, the man machine interface, and the plant specific algorithms, to proceed in parallel with the fabrication of the panels, the installation of the equipment and the generic testing thereof.

  3. Steam Conservation and Boiler Plant Efficiency Advancements

    E-Print Network [OSTI]

    Fiorino, D. P.

    This paper examines several cost-effective steam conservation and boiler plant efficiency advancements that were implemented during a recently completed central steam boiler plant replacement project at a very large semiconductor manufacturing...

  4. advanced power plant: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  5. advanced nuclear plant: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  6. advanced nuclear plants: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  7. advanced steam plant: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  8. advanced steam plants: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  9. advanced passive plant: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  10. advanced power plants: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  11. advanced astroculture plant: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  12. Advanced Power Plant Development and Analysis Methodologies

    SciTech Connect (OSTI)

    A.D. Rao; G.S. Samuelsen; F.L. Robson; B. Washom; S.G. Berenyi

    2006-06-30T23:59:59.000Z

    Under the sponsorship of the U.S. Department of Energy/National Energy Technology Laboratory, a multi-disciplinary team led by the Advanced Power and Energy Program of the University of California at Irvine is defining the system engineering issues associated with the integration of key components and subsystems into advanced power plant systems with goals of achieving high efficiency and minimized environmental impact while using fossil fuels. These power plant concepts include 'Zero Emission' power plants and the 'FutureGen' H2 co-production facilities. The study is broken down into three phases. Phase 1 of this study consisted of utilizing advanced technologies that are expected to be available in the 'Vision 21' time frame such as mega scale fuel cell based hybrids. Phase 2 includes current state-of-the-art technologies and those expected to be deployed in the nearer term such as advanced gas turbines and high temperature membranes for separating gas species and advanced gasifier concepts. Phase 3 includes identification of gas turbine based cycles and engine configurations suitable to coal-based gasification applications and the conceptualization of the balance of plant technology, heat integration, and the bottoming cycle for analysis in a future study. Also included in Phase 3 is the task of acquiring/providing turbo-machinery in order to gather turbo-charger performance data that may be used to verify simulation models as well as establishing system design constraints. The results of these various investigations will serve as a guide for the U. S. Department of Energy in identifying the research areas and technologies that warrant further support.

  13. Advanced Power Plant Development and Analyses Methodologies

    SciTech Connect (OSTI)

    G.S. Samuelsen; A.D. Rao

    2006-02-06T23:59:59.000Z

    Under the sponsorship of the U.S. Department of Energy/National Energy Technology Laboratory, a multi-disciplinary team led by the Advanced Power and Energy Program of the University of California at Irvine is defining the system engineering issues associated with the integration of key components and subsystems into advanced power plant systems with goals of achieving high efficiency and minimized environmental impact while using fossil fuels. These power plant concepts include ''Zero Emission'' power plants and the ''FutureGen'' H{sub 2} co-production facilities. The study is broken down into three phases. Phase 1 of this study consisted of utilizing advanced technologies that are expected to be available in the ''Vision 21'' time frame such as mega scale fuel cell based hybrids. Phase 2 includes current state-of-the-art technologies and those expected to be deployed in the nearer term such as advanced gas turbines and high temperature membranes for separating gas species and advanced gasifier concepts. Phase 3 includes identification of gas turbine based cycles and engine configurations suitable to coal-based gasification applications and the conceptualization of the balance of plant technology, heat integration, and the bottoming cycle for analysis in a future study. Also included in Phase 3 is the task of acquiring/providing turbo-machinery in order to gather turbo-charger performance data that may be used to verify simulation models as well as establishing system design constraints. The results of these various investigations will serve as a guide for the U. S. Department of Energy in identifying the research areas and technologies that warrant further support.

  14. ARIES-AT: AN ADVANCED TOKAMAK, ADVANCED TECHNOLOGY FUSION POWER PLANT

    E-Print Network [OSTI]

    California at San Diego, University of

    ARIES-AT: AN ADVANCED TOKAMAK, ADVANCED TECHNOLOGY FUSION POWER PLANT F. Najmabadi, S. C. Jardin*,6 of high-performance tokamak plasmas together with advanced technology in a fusion power plant. Several and advanced technology leads to attractive fusion power plant with excellent safety and environmental

  15. Energy Efficiency Improvement and Cost Saving Opportunities for the Pharmaceutical Industry. An ENERGY STAR Guide for Energy and Plant Managers

    SciTech Connect (OSTI)

    Galitsky, Christina; Galitsky, Christina; Chang, Sheng-chieh; Worrell, Ernst; Masanet, Eric

    2008-03-01T23:59:59.000Z

    The U.S. pharmaceutical industry consumes almost $1 billion in energy annually. Energy efficiency improvement is an important way to reduce these costs and to increase predictable earnings, especially in times of high energy price volatility. There are a variety of opportunities available at individual plants in the U.S. pharmaceutical industry to reduce energy consumption in a cost-effective manner. This Energy Guide discusses energy efficiency practices and energy efficient technologies that can be implemented at the component, process, system, and organizational levels. A discussion of the trends, structure, and energy consumption characteristics of the U.S. pharmaceutical industry is provided along with a description of the major process steps in the pharmaceutical manufacturing process. Expected savings in energy and energy-related costs are given for many energy efficiency measures, based on case study data from real-world applications in pharmaceutical and related facilities worldwide. Typical measure payback periods and references to further information in the technical literature are also provided, when available. The information in this Energy Guide is intended to help energy and plant managers reduce energy consumption in a cost-effective manner while meeting regulatory requirements and maintaining the quality of products manufactured. At individual plants, further research on the economics of the measures?as well as their applicability to different production practices?is needed to assess potential implementation of selected technologies.

  16. Plant maintenance and advanced reactors issue, 2008

    SciTech Connect (OSTI)

    Agnihotri, Newal (ed.)

    2009-09-15T23:59:59.000Z

    The focus of the September-October issue is on plant maintenance and advanced reactors. Major articles/reports in this issue include: Technologies of national importance, by Tsutomu Ohkubo, Japan Atomic Energy Agency, Japan; Modeling and simulation advances brighten future nuclear power, by Hussein Khalil, Argonne National Laboratory, Energy and desalination projects, by Ratan Kumar Sinha, Bhabha Atomic Research Centre, India; A plant with simplified design, by John Higgins, GE Hitachi Nuclear Energy; A forward thinking design, by Ray Ganthner, AREVA; A passively safe design, by Ed Cummins, Westinghouse Electric Company; A market-ready design, by Ken Petrunik, Atomic Energy of Canada Limited, Canada; Generation IV Advanced Nuclear Energy Systems, by Jacques Bouchard, French Commissariat a l'Energie Atomique, France, and Ralph Bennett, Idaho National Laboratory; Innovative reactor designs, a report by IAEA, Vienna, Austria; Guidance for new vendors, by John Nakoski, U.S. Nuclear Regulatory Commission; Road map for future energy, by John Cleveland, International Atomic Energy Agency, Vienna, Austria; and, Vermont's largest source of electricity, by Tyler Lamberts, Entergy Nuclear Operations, Inc. The Industry Innovation article is titled Intelligent monitoring technology, by Chris Demars, Exelon Nuclear.

  17. Advanced nuclear plant control room complex

    DOE Patents [OSTI]

    Scarola, Kenneth (Windsor, CT); Jamison, David S. (Windsor, CT); Manazir, Richard M. (North Canton, CT); Rescorl, Robert L. (Vernon, CT); Harmon, Daryl L. (Enfield, CT)

    1993-01-01T23:59:59.000Z

    An advanced control room complex for a nuclear power plant, including a discrete indicator and alarm system (72) which is nuclear qualified for rapid response to changes in plant parameters and a component control system (64) which together provide a discrete monitoring and control capability at a panel (14-22, 26, 28) in the control room (10). A separate data processing system (70), which need not be nuclear qualified, provides integrated and overview information to the control room and to each panel, through CRTs (84) and a large, overhead integrated process status overview board (24). The discrete indicator and alarm system (72) and the data processing system (70) receive inputs from common plant sensors and validate the sensor outputs to arrive at a representative value of the parameter for use by the operator during both normal and accident conditions, thereby avoiding the need for him to assimilate data from each sensor individually. The integrated process status board (24) is at the apex of an information hierarchy that extends through four levels and provides access at each panel to the full display hierarchy. The control room panels are preferably of a modular construction, permitting the definition of inputs and outputs, the man machine interface, and the plant specific algorithms, to proceed in parallel with the fabrication of the panels, the installation of the equipment and the generic testing thereof.

  18. Energy Efficiency Improvement and Cost Saving Opportunities for the Pharmaceutical Industry. An ENERGY STAR Guide for Energy and Plant Managers

    E-Print Network [OSTI]

    Galitsky, Christina

    2008-01-01T23:59:59.000Z

    Journal. July: 40-51. Pharmaceutical Industry Association ofthan 25% of the U.S. pharmaceutical industry’s total valueadded of the U.S. pharmaceutical industry, Billion $/year

  19. Energy Efficiency Improvement and Cost Saving Opportunities for the Pharmaceutical Industry. An ENERGY STAR Guide for Energy and Plant Managers

    E-Print Network [OSTI]

    Galitsky, Christina

    2008-01-01T23:59:59.000Z

    often used is that boiler efficiency can be increased by 1%gas by 1% increases boiler efficiency by 2.5% (CIPEC 2001).Conservation and Boiler Plant Efficiency Advancements. 22 nd

  20. Cost-Effective Industrial Boiler Plant Efficiency Advancements

    E-Print Network [OSTI]

    Fiorino, D. P.

    Natural gas and electricity are expensive to the extent that annual fuel and power costs can approach the initial cost of an industrial boiler plant. Within this context, this paper examines several cost-effective efficiency advancements that were...

  1. Announcement Advances in Photosynthesis and Respiration: Focus on Plant

    E-Print Network [OSTI]

    Govindjee "Gov"

    Announcement Advances in Photosynthesis and Respiration: Focus on Plant Respiration I am delighted to announce the publication, in the Advances in Photosynthesis and Respiration (AIPH) series, of two books, Michael T. Madigan and Carl E. Bauer, editors, 1995); 3. Biophysical Techniques in Photosynthesis (Jan

  2. Software Framework for Advanced Power Plant Simulations

    SciTech Connect (OSTI)

    John Widmann; Sorin Munteanu; Aseem Jain; Pankaj Gupta; Mark Moales; Erik Ferguson; Lewis Collins; David Sloan; Woodrow Fiveland; Yi-dong Lang; Larry Biegler; Michael Locke; Simon Lingard; Jay Yun

    2010-08-01T23:59:59.000Z

    This report summarizes the work accomplished during the Phase II development effort of the Advanced Process Engineering Co-Simulator (APECS). The objective of the project is to develop the tools to efficiently combine high-fidelity computational fluid dynamics (CFD) models with process modeling software. During the course of the project, a robust integration controller was developed that can be used in any CAPE-OPEN compliant process modeling environment. The controller mediates the exchange of information between the process modeling software and the CFD software. Several approaches to reducing the time disparity between CFD simulations and process modeling have been investigated and implemented. These include enabling the CFD models to be run on a remote cluster and enabling multiple CFD models to be run simultaneously. Furthermore, computationally fast reduced-order models (ROMs) have been developed that can be 'trained' using the results from CFD simulations and then used directly within flowsheets. Unit operation models (both CFD and ROMs) can be uploaded to a model database and shared between multiple users.

  3. Gasification CFD Modeling for Advanced Power Plant Simulations

    SciTech Connect (OSTI)

    Zitney, S.E.; Guenther, C.P.

    2005-09-01T23:59:59.000Z

    In this paper we have described recent progress on developing CFD models for two commercial-scale gasifiers, including a two-stage, coal slurry-fed, oxygen-blown, pressurized, entrained-flow gasifier and a scaled-up design of the PSDF transport gasifier. Also highlighted was NETL’s Advanced Process Engineering Co-Simulator for coupling high-fidelity equipment models with process simulation for the design, analysis, and optimization of advanced power plants. Using APECS, we have coupled the entrained-flow gasifier CFD model into a coal-fired, gasification-based FutureGen power and hydrogen production plant. The results for the FutureGen co-simulation illustrate how the APECS technology can help engineers better understand and optimize gasifier fluid dynamics and related phenomena that impact overall power plant performance.

  4. Advanced binary geothermal power plants: Limits of performance

    SciTech Connect (OSTI)

    Bliem, C.J.; Mines, G.L.

    1991-01-01T23:59:59.000Z

    The Heat Cycle Research Program is investigating potential improvements to power cycles utilizing moderate temperature geothermal resources to produce electrical power. Investigations have specifically examined Rankine cycle binary power systems. Binary Rankine cycles are more efficient than the flash steam cycles at moderate resource temperature, achieving a higher net brine effectiveness. At resource conditions similar to those at the Heber binary plant, it has been shown that mixtures of saturated hydrocarbons (alkanes) or halogenated hydrocarbons operating in a supercritical Rankine cycle gave improved performance over Rankine cycles with the pure working fluids executing single or dual boiling cycles or supercritical cycles. Recently, other types of cycles have been proposed for binary geothermal service. This report explores the feasible limits on efficiency of a plant given practical limits on equipment performance and discusses the methods used in these advanced concept plants to achieve the maximum possible efficiency. (Here feasible is intended to mean reasonably achievable and not cost-effective.) No direct economic analysis has been made because of the sensitivity of economic results to site specific input. The limit of performance of three advanced plants were considered in this report. The performance predictions were taken from the developers of each concept. The advanced plants considered appear to be approaching the feasible limit of performance. Ultimately, the plant designer must weigh the advantages and disadvantages of the the different cycles to find the best plant for a given service. In addition, this report presents a standard of comparison of the work which has been done in the Heat Cycle Research Program and in the industrial sector by Exergy, Inc. and Polythermal Technologies. 18 refs., 16 figs., 1 tab.

  5. Over the last decade, some of the most exciting advances in healthcare have been the result of pharmaceutical research and development. These life-enhancing

    E-Print Network [OSTI]

    Lin, Xiaodong

    with a special knowledge of the healthcare and pharmaceutical industry. Designed to answer this need, the Rutgers in the pharmaceutical industry. New Jersey's Connection to Industry Rutgers Business School has turned a geographic, Pharmaceutical Industry Scholar; Manager, Bristol-Myers Squibb. Pharmaceutical Management MBA Come with your

  6. Over the last decade, some of the most exciting advances in healthcare have been the result of pharmaceutical research and development. These life-enhancing

    E-Print Network [OSTI]

    Lin, Xiaodong

    with a special knowledge of the healthcare and pharmaceutical industry. Designed to answer this need, the Rutgers in the pharmaceutical industry. New Jersey's Connection to Industry Rutgers Business School has turned a geographic Whitney Lesch, MBA `10, Pharmaceutical Industry Scholar; Manager, Bristol-Myers Squibb. Pharmaceutical

  7. Requirements for advanced simulation of nuclear reactor and chemicalseparation plants.

    SciTech Connect (OSTI)

    Palmiotti, G.; Cahalan, J.; Pfeiffer, P.; Sofu, T.; Taiwo, T.; Wei,T.; Yacout, A.; Yang, W.; Siegel, A.; Insepov, Z.; Anitescu, M.; Hovland,P.; Pereira, C.; Regalbuto, M.; Copple, J.; Willamson, M.

    2006-12-11T23:59:59.000Z

    This report presents requirements for advanced simulation of nuclear reactor and chemical processing plants that are of interest to the Global Nuclear Energy Partnership (GNEP) initiative. Justification for advanced simulation and some examples of grand challenges that will benefit from it are provided. An integrated software tool that has its main components, whenever possible based on first principles, is proposed as possible future approach for dealing with the complex problems linked to the simulation of nuclear reactor and chemical processing plants. The main benefits that are associated with a better integrated simulation have been identified as: a reduction of design margins, a decrease of the number of experiments in support of the design process, a shortening of the developmental design cycle, and a better understanding of the physical phenomena and the related underlying fundamental processes. For each component of the proposed integrated software tool, background information, functional requirements, current tools and approach, and proposed future approaches have been provided. Whenever possible, current uncertainties have been quoted and existing limitations have been presented. Desired target accuracies with associated benefits to the different aspects of the nuclear reactor and chemical processing plants were also given. In many cases the possible gains associated with a better simulation have been identified, quantified, and translated into economical benefits.

  8. Indicator system for advanced nuclear plant control complex

    DOE Patents [OSTI]

    Scarola, Kenneth (Windsor, CT); Jamison, David S. (Windsor, CT); Manazir, Richard M. (North Canton, CT); Rescorl, Robert L. (Vernon, CT); Harmon, Daryl L. (Enfield, CT)

    1993-01-01T23:59:59.000Z

    An advanced control room complex for a nuclear power plant, including a discrete indicator and alarm system (72) which is nuclear qualified for rapid response to changes in plant parameters and a component control system (64) which together provide a discrete monitoring and control capability at a panel (14-22, 26, 28) in the control room (10). A separate data processing system (70), which need not be nuclear qualified, provides integrated and overview information to the control room and to each panel, through CRTs (84) and a large, overhead integrated process status overview board (24). The discrete indicator and alarm system (72) and the data processing system (70) receive inputs from common plant sensors and validate the sensor outputs to arrive at a representative value of the parameter for use by the operator during both normal and accident conditions, thereby avoiding the need for him to assimilate data from each sensor individually. The integrated process status board (24) is at the apex of an information hierarchy that extends through four levels and provides access at each panel to the full display hierarchy. The control room panels are preferably of a modular construction, permitting the definition of inputs and outputs, the man machine interface, and the plant specific algorithms, to proceed in parallel with the fabrication of the panels, the installation of the equipment and the generic testing thereof.

  9. Requirements for Advanced Simulation of Nuclear Reactor and Chemical Separation Plants

    E-Print Network [OSTI]

    Anitescu, Mihai

    Requirements for Advanced Simulation of Nuclear Reactor and Chemical Separation Plants ANL-AFCI-168 of Nuclear Reactor and Chemical Separation Plants ANL-AFCI-168 by G. Palmiotti, J. Cahalan, P. Pfeiffer, T;2 ANL-AFCI-168 Requirements for Advanced Simulation of Nuclear Reactor and Chemical Separation Plants G

  10. Advanced Neutron Source reactor control and plant protection systems design

    SciTech Connect (OSTI)

    Anderson, J.L.; Battle, R.E.; March-Leuba, J. (Oak Ridge National Lab., TN (United States)); Khayat, M.I. (Tennessee Univ., Knoxville, TN (United States))

    1992-01-01T23:59:59.000Z

    This paper describes the reactor control and plant protection systems' conceptual design of the Advanced Neutron Source (ANS). The Plant Instrumentation, Control, and Data Systems and the Reactor Instrumentation and Control System of the ANS are planned as an integrated digital system with a hierarchical, distributed control structure of qualified redundant subsystems and a hybrid digital/analog protection system to achieve the necessary fast response for critical parameters. Data networks transfer information between systems for control, display, and recording. Protection is accomplished by the rapid insertion of negative reactivity with control rods or other reactivity mechanisms to shut down the fission process and reduce heat generation in the fuel. The shutdown system is designed for high functional reliability by use of conservative design features and a high degree of redundance and independence to guard against single failures. Two independent reactivity control systems of different design principles are provided, and each system has multiple independent rods or subsystems to provide appropriate margin for malfunctions such as stuck rods or other single failures. Each system is capable of maintaining the reactor in a cold shutdown condition independently of the functioning of the other system. A highly reliable, redundant channel control system is used not only to achieve high availability of the reactor, but also to reduce challenges to the protection system by maintaining important plant parameters within appropriate limits. The control system has a number of contingency features to maintain acceptable, off-normal conditions in spite of limited control or plant component failures thereby further reducing protection system challenges.

  11. Advanced Li-Ion Polymer Battery Cell Manufacturing Plant in USA...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Li-Ion Polymer Battery Cell Manufacturing Plant in USA Advanced Li-Ion Polymer Battery Cell Manufacturing Plant in USA 2012 DOE Hydrogen and Fuel Cells Program and Vehicle...

  12. The ARIES Advanced And Conservative Tokamak (ACT) Power Plant Study

    SciTech Connect (OSTI)

    Kessel, C. E.; Poli, F. M.; Ghantous, K.; Gorelenkov, N. [Princeton Plasma Physics Lab., Princeton, NJ (United States)] [Princeton Plasma Physics Lab., Princeton, NJ (United States); Tillack, M. S.; Najmabadi, F.; Wang, X. R.; Navaei, D.; Toudeshki, H. H. [Univ. of California, San Diego, CA (United States)] [Univ. of California, San Diego, CA (United States); Koehly, C. [Karlsruhe Inst. of Technology, Karlsruhe (Germany)] [Karlsruhe Inst. of Technology, Karlsruhe (Germany); El-Guebaly, L.; Blanchard, J. P.; Martin, C. J.; Mynsburge, L. [Univ. of Wisconsin, Madison, WI (United States)] [Univ. of Wisconsin, Madison, WI (United States); Humrickhouse, P. [Idaho National Lab., Idaho Falls, ID (United States)] [Idaho National Lab., Idaho Falls, ID (United States); Rensink, M. E.; Rognlien, T. D. [Lawrence Livermore National Lab., Livermore, CA (United States)] [Lawrence Livermore National Lab., Livermore, CA (United States); Yoda, M.; Abdel-Khalik, S. I.; Hageman, M. D.; Mills, B. H.; Radar, J. D.; Sadowski, D. L. [Georgia Inst. of Technology, Atlanta, GA (United States)] [Georgia Inst. of Technology, Atlanta, GA (United States); Snyder, P. B.; St. John, H.; Turnbull, A. D. [General Atomics, La Jolla, CA (United States)] [General Atomics, La Jolla, CA (United States); Waganer, L. M.; Malang, S.; Rowcliffe, A. F.

    2014-03-05T23:59:59.000Z

    Tokamak power plants are studied with advanced and conservative design philosophies in order to identify the impacts on the resulting designs and to provide guidance to critical research needs. Incorporating updated physics understanding, and using more sophisticated engineering and physics analysis, the tokamak configurations have developed a more credible basis compared to older studies. The advanced configuration assumes a self-cooled lead lithium (SCLL) blanket concept with SiC composite structural material with 58% thermal conversion efficiency. This plasma has a major radius of 6.25 m, a toroidal field of 6.0 T, a q95 of 4.5, a {beta}N{sup total} of 5.75, H{sub 98} of 1.65, n/nGr of 1.0, and peak divertor heat flux of 13.7 MW/m{sup 2}. The conservative configuration assumes a dual coolant lead lithium (DCLL) blanket concept with ferritic steel structural material and helium coolant, achieving a thermal conversion efficiency of 45%. The plasma major radius is 9.75 m, a toroidal field of 8.75 T, a q95 of 8.0, a {beta}N{sup total} of 2.5, H{sub 98} of 1.25, n/n{sub Gr} of 1.3, and peak divertor heat flux of 10 MW/m{sup 2}. The divertor heat flux treatment with a narrow power scrape-off width has driven the plasmas to larger major radius. Edge and divertor plasma simulations are targeting a basis for high radiated power fraction in the divertor, which is necessary for solutions to keep the peak heat flux in the range of 10-15 MW/m{sup 2}. Combinations of the advanced and conservative approaches show intermediate sizes. A new systems code using a database approach has been used and shows that the operating point is really an operating zone with some range of plasma and engineering parameters and very similar costs of electricity. Papers in this issue provide more detailed discussion of the work summarized here.

  13. Evaluation of air toxic emissions from advanced and conventional coal-fired power plants

    SciTech Connect (OSTI)

    Chu, P.; Epstein, M. [Electric Power Research Institute, Palo Alto, CA (United States); Gould, L. [Department of Energy, Pittsburgh, PA (United States); Botros, P. [Department of Energy, Morgantown, WV (United States)

    1995-12-31T23:59:59.000Z

    This paper evaluates the air toxics measurements at three advanced power systems and a base case conventional fossil fuel power plant. The four plants tested include a pressurized fluidized bed combustor, integrated gasification combined cycle, circulating fluidized bed combustor, and a conventional coal-fired plant.

  14. Impact of Advanced Physics and Technology on the Attractiveness of Tokamak Fusion Power Plants

    E-Print Network [OSTI]

    Najmabadi, Farrokh

    Impact of Advanced Physics and Technology on the Attractiveness of Tokamak Fusion Power Plants--During the past ten years, the ARIES Team has studied a variety of tokamak power plants with different degrees to apply lessons learned from each ARIES design to the next. The results of ARIES tokamak power plant

  15. Defining the needs for gas centrifuge enrichment plants advanced safeguards

    SciTech Connect (OSTI)

    Boyer, Brian David [Los Alamos National Laboratory; Erpenbeck, Heather H [Los Alamos National Laboratory; Miller, Karen A [Los Alamos National Laboratory; Swinhoe, Martyn T [Los Alamos National Laboratory; Ianakiev, Kiril [Los Alamos National Laboratory; Marlow, Johnna B [Los Alamos National Laboratory

    2010-04-05T23:59:59.000Z

    Current safeguards approaches used by the International Atomic Energy Agency (IAEA) at gas centrifuge enrichment plants (GCEPs) need enhancement in order to verify declared low-enriched (LEU) production, detect undeclared LEU production and detect highly enriched uranium (HEU) production with adequate detection probability using nondestructive assay (NDA) techniques. At present inspectors use attended systems, systems needing the presence of an inspector for operation, during inspections to verify the mass and {sup 235}U enrichment of declared UF{sub 6} containers used in the process of enrichment at GCEPs. In verifying declared LEU production, the inspectors also take samples for off-site destructive assay (DA) which provide accurate data, with 0.1% to 0.5% measurement uncertainty, on the enrichment of the UF{sub 6} feed, tails, and product. However, taking samples of UF{sub 6} for off-site analysis is a much more labor and resource intensive exercise for the operator and inspector. Furthermore, the operator must ship the samples off-site to the IAEA laboratory which delays the timeliness of results and interruptions to the continuity of knowledge (CofK) of the samples during their storage and transit. This paper contains an analysis of possible improvements in unattended and attended NDA systems such as process monitoring and possible on-site analysis of DA samples that could reduce the uncertainty of the inspector's measurements and provide more effective and efficient IAEA GCEPs safeguards. We also introduce examples advanced safeguards systems that could be assembled for unattended operation.

  16. Saft America Advanced Batteries Plant Celebrates Grand Opening...

    Energy Savers [EERE]

    Florida, factory, which will produce advanced lithium-ion batteries to power electric vehicles and other applications. Saft America estimates it will create nearly 280...

  17. Microstructure and Creep Strength of Welds in Advanced Ferritic Power Plant Steels

    E-Print Network [OSTI]

    Cambridge, University of

    Microstructure and Creep Strength of Welds in Advanced Ferritic Power Plant Steels Fujio ABE) power plant at 650 o C (923 K).1 Critical issues for the development of ferritic steels for 650 o C USC joints for tungsten-strengthened advanced 9-12%Cr steels, ASME-P92 (9Cr-0.5Mo-1.8W-VNb), ASME-P122 (11Cr

  18. Advances in Energy Reduction in Methanol Plant Design

    E-Print Network [OSTI]

    Huggins, P. J.; Griffiths, G. W.

    1982-01-01T23:59:59.000Z

    which are still under development are outlined. In particular, the paper presents Davy McKee's version of the next generation of synthesis reactor. The paper also examines the economic justification of the energy saving steps. To complement advances...

  19. ECONOMIC COMPARISON OF MHD EQUILIBRIUM OPTIONS FOR ADVANCED STEADY STATE TOKAMAK POWER PLANTS

    E-Print Network [OSTI]

    Najmabadi, Farrokh

    ECONOMIC COMPARISON OF MHD EQUILIBRIUM OPTIONS FOR ADVANCED STEADY STATE TOKAMAK POWER PLANTS D for commercial tokamak power plants. The economic prospects of future designs are compared for several tokamak a simplified economic model and selecting uniform engineering performance parameters, this comparison

  20. INTERNATIONAL CONFERENCE ON ADVANCES IN PLANT SCIENCES (ICAPS 2012)

    E-Print Network [OSTI]

    in Biodiversity Conservation", covered various aspects of plant sciences, including agro-biodiversity culture and the biodiversity in Thailand. I want to thank the NRF and the DST/NRF Centre of Excellence

  1. Agua Caliente, World's Largest Solar Photovoltaic Plant, Helps Advance

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion |Energy UsageAUDITVehicles » Alternative FuelNewsWashington Auto ShowAtoActiveAdvanced

  2. Interacting With the Pharmaceutical Industry

    E-Print Network [OSTI]

    Hayden, Stephen R

    2003-01-01T23:59:59.000Z

    INTERACTING WITH THE PHARMACEUTICAL INDUSTRY Stephen R.to interactions with the pharmaceutical industry! This is ancome from the pharmaceutical industry. It is also reality

  3. The advanced PFB process: Pilot plant results and design studies

    SciTech Connect (OSTI)

    Robertson, A. [Foster Wheeler Development Corp., Livingston, NJ (United States); Domeracki, W. [Westinghouse Power Generation Business Group, Orlando, FL (United States); Horazak, D. [Gilbert/Commonwealth, Green Hills, PA (United States); Newby, R. [Westinghouse Science and Technology Center, Pittsburgh, PA (United States); Rehmat, A. [Institute of Gas Technology, Chicago IL (United States)

    1993-11-01T23:59:59.000Z

    The plant being developed is a hybrid of two technologies; it incorporates the partial gasification of coal in a vessel called the carbonizer and the combustion of the resultant char residue in a circulating pressurized fluidized bed combustor (CPFBC). In this plant, coal is fed to a pressurized carbonizer that produces a low-Btu fuel gas and char. After passing through a cyclone and a ceramic barrier filter to remove gas-entrained particulates, the fuel gas is burned in a topping combustor to produce the energy required to drive a gas turbine. The gas turbine drives a generator and a compressor that feeds air to the carbonizer, a CPFBC, and a fluidized bed heat exchanger (FBHE). The carbonizer char is burned in the CPFBC with high excess air. The vitiated air from the CPFBC supports combustion of the fuel gas in the gas turbine topping combustor. Steam generated in a heat-recovery steam generator (HRSG) downstream of the gas turbine and in the FBHE associated with the CPFBC drives the steam turbine generator that furnishes the balance of electric power delivered by the plant. The low-Btu gas is produced in the carbonizer by pyrolysis/mild devolatilization of coal in a fluidized bed reactor. Because this unit operates at temperatures much lower than gasifiers currently under development, it also produces a char residue. Left untreated, the fuel gas will contain hydrogen sulfide and sulfur-containing tar/light oil vapors; therefore, lime-based sorbents are injected into the carbonizer to catalytically enhance tar cracking and to capture sulfur as calcium sulfide. Sulfur is captured in situ, and the raw fuel gas is fired hot. Thus the expensive, complex, fuel gas heat exchangers and the chemical or sulfur-capturing bed cleanup systems that are part of the coal gasification combined-cycle plants now being developed are eliminated.

  4. Performance and risks of advanced pulverized-coal plants

    SciTech Connect (OSTI)

    Nalbandian, H. [IEA Clean Coal Centre, London (United Kingdom)

    2009-07-01T23:59:59.000Z

    This article is based on an in-depth report of the same title published by the IEA Clean Coal Centre, CCC/135 (see Coal Abstracts entry Sep 2008 00535). It discusses the commercial, developmental and future status of pulverized fuel power plants including subcritical supercritical and ultra supercritical systems of pulverized coal combustion, the most widely used technology in coal-fired power generation. 1 fig., 1 tab.

  5. Advanced conceptual design report: T Plant secondary containment and leak detection upgrades. Project W-259

    SciTech Connect (OSTI)

    Hookfin, J.D.

    1995-05-12T23:59:59.000Z

    The T Plant facilities in the 200-West Area of the Hanford site were constructed in the early 1940s to produce nuclear materials in support of national defense activities. T Plant includes the 271-T facility, the 221-T facility, and several support facilities (eg, 2706-T), utilities, and tanks/piping systems. T Plant has been recommended as the primary interim decontamination facility for the Hanford site. Project W-259 will provide capital upgrades to the T Plant facilities to comply with Federal and State of Washington environmental regulations for secondary containment and leak detection. This document provides an advanced conceptual design concept that complies with functional requirements for the T Plant Secondary Containment and Leak Detection upgrades.

  6. Study of Pu consumption in Advanced Light Water Reactors. Evaluation of GE Advanced Boiling Water Reactor plants

    SciTech Connect (OSTI)

    Not Available

    1993-05-13T23:59:59.000Z

    Timely disposal of the weapons plutonium is of paramount importance to permanently safeguarding this material. GE`s 1300 MWe Advanced Boiling Water Reactor (ABWR) has been designed to utilize fill] core loading of mixed uranium-plutonium oxide fuel. Because of its large core size, a single ABWR reactor is capable of disposing 100 metric tons of plutonium within 15 years of project inception in the spiking mode. The same amount of material could be disposed of in 25 years after the start of the project as spent fuel, again using a single reactor, while operating at 75 percent capacity factor. In either case, the design permits reuse of the stored spent fuel assemblies for electrical energy generation for the remaining life of the plant for another 40 years. Up to 40 percent of the initial plutonium can also be completely destroyed using ABWRS, without reprocessing, either by utilizing six ABWRs over 25 years or by expanding the disposition time to 60 years, the design life of the plants and using two ABWRS. More complete destruction would require the development and testing of a plutonium-base fuel with a non-fertile matrix for an ABWR or use of an Advanced Liquid Metal Reactor (ALMR). The ABWR, in addition, is fully capable of meeting the tritium target production goals with already developed target technology.

  7. ADVANCED HYDROGEN TRANSPORT MEMBRANES FOR VISION 21 FOSSIL FUEL PLANTS

    SciTech Connect (OSTI)

    Shane E. Roark; Tony F. Sammells; Richard A. Mackay; Adam E. Calihman; Lyrik Y. Pitzman; Tom F. Barton; Sara L. Rolfe; Richard N. Kleiner; James E. Stephan; Mike J. Holmes; Aaron L. Wagner

    2001-07-30T23:59:59.000Z

    Eltron Research Inc., and team members, are developing an environmentally benign, inexpensive, and efficient method for separating hydrogen from gas mixtures produced during industrial processes, such as coal gasification. This project was motivated by the National Energy Technology Laboratory (NETL) Vision 21 initiative which seeks to economically eliminate environmental concerns associated with the use of fossil fuels. This objective is being pursued using dense membranes based in part on Eltron-patented ceramic materials with a demonstrated ability for proton and electron conduction. The technical goals are being addressed by modifying single-phase and composite membrane composition and microstructure to maximize proton and electron conductivity without loss of material stability. Ultimately, these materials must enable hydrogen separation at practical rates under ambient and high-pressure conditions, without deactivation in the presence of feedstream components such as carbon dioxide, water, and sulfur. During this quarter, ceramic, cermet (ceramic/metal), and thin film membranes were prepared, characterized, and evaluated for H{sub 2} transport. For selected ceramic membrane compositions an optimum range for transition metal doping was identified, and it was determined that highest proton conductivity occurred for two-phase ceramic materials. Furthermore, a relationship between transition metal dopant atomic number and conductivity was observed. Ambipolar conductivities of {approx}6 x 10{sup -3} S/cm were achieved for these materials, and {approx} 1-mm thick membranes generated H{sub 2} transport rates as high as 0.3 mL/min/cm{sup 2}. Cermet membranes during this quarter were found to have a maximum conductivity of 3 x 10{sup -3} S/cm, which occurred at a metal phase contact of 36 vol.%. Homogeneous dense thin films were successfully prepared by tape casting and spin coating; however, there remains an unacceptably high difference in shrinkage rates between the film and support, which led to membrane instability. Further improvements in high pressure membrane seals also were achieved during this quarter, and a maximum pressure of 100 psig was attained. CoorsTek optimized many of the processing variables relevant to manufacturing scale production of ceramic H{sub 2} transport membranes, and SCI used their expertise to deposit a range of catalysts compositions onto ceramic membrane surfaces. Finally, MTI compiled relevant information regarding Vision 21 fossil fuel plant operation parameters, which will be used as a starting point for assessing the economics of incorporating a H{sub 2} separation unit.

  8. Effects of regional insolation differences upon advanced solar thermal electric power plant performance and energy costs

    SciTech Connect (OSTI)

    Latta, A.F.; Bowyer, J.M.; Fujita, T.; Richter, P.H.

    1980-02-01T23:59:59.000Z

    This study determines the performance and cost of four 10 MWe advanced solar thermal electric power plants sited in various regions of the continental United States. The solar plants are conceptualized to begin commercial operation in the year 2000. It is assumed that major subsystem performance will have improved substantially as compared to that of pilot plants currently operating or under construction. The net average annual system efficiency is therefore roughly twice that of current solar thermal electric power plant designs. Similarly, capital costs reflecting goals based on high-volume mass production that are considered to be appropriate for the year 2000 have been used. These costs, which are approximately an order of magnitude below the costs of current experimental projects, are believed to be achievable as a result of the anticipated sizeable solar penetration into the energy market in the 1990 to 2000 timeframe. The paraboloidal dish, central receiver, cylindrical parabolic trough, and compound parabolic concentrators comprise the advanced collector concepts studied. All concepts exhibit their best performance when sited in regional areas such as the sunbelt where the annual insolation is high. The regional variation in solar plant performance has been assessed in relation to the expected rise in the future cost of residential and commercial electricity in the same regions. A discussion of the regional insolation data base, a description of the solar systems performance and costs, and a presentation of a range for the forecast cost of conventional electricity by region and nationally over the next several decades are given.

  9. Advanced Reactor Licensing: Experience with Digital I&C Technology in Evolutionary Plants

    SciTech Connect (OSTI)

    Wood, RT

    2004-09-27T23:59:59.000Z

    This report presents the findings from a study of experience with digital instrumentation and controls (I&C) technology in evolutionary nuclear power plants. In particular, this study evaluated regulatory approaches employed by the international nuclear power community for licensing advanced l&C systems and identified lessons learned. The report (1) gives an overview of the modern l&C technologies employed at numerous evolutionary nuclear power plants, (2) identifies performance experience derived from those applications, (3) discusses regulatory processes employed and issues that have arisen, (4) captures lessons learned from performance and regulatory experience, (5) suggests anticipated issues that may arise from international near-term deployment of reactor concepts, and (6) offers conclusions and recommendations for potential activities to support advanced reactor licensing in the United States.

  10. Mapping Complexity Sources in Nuclear Power Plant Domains Understanding the sources of complexity in advanced Nuclear Power Plant (NPP) control rooms and their

    E-Print Network [OSTI]

    Cummings, Mary "Missy"

    Mapping Complexity Sources in Nuclear Power Plant Domains Understanding the sources of complexity in advanced Nuclear Power Plant (NPP) control rooms and their effects on human reliability is critical of complexity leveraging network theory. INTRODUCTION The nuclear power industry in United States has declined

  11. The Physics Basis For An Advanced Physics And Advanced Technology Tokamak Power Plant Configuration, ARIES-ACT1

    SciTech Connect (OSTI)

    Charles Kessel, et al

    2014-03-05T23:59:59.000Z

    The advanced physics and advanced technology tokamak power plant ARIES-ACT1 has a major radius of 6.25 m at aspect ratio of 4.0, toroidal field of 6.0 T, strong shaping with elongation of 2.2 and triangularity of 0.63. The broadest pressure cases reached wall stabilized ?N ~ 5.75, limited by n=3 external kink mode requiring a conducting shell at b/a = 0.3, and requiring plasma rotation, feedback, and or kinetic stabilization. The medium pressure peaking case reached ?N = 5.28 with BT = 6.75, while the peaked pressure case reaches ?N < 5.15. Fast particle MHD stability shows that the alpha particles are unstable, but this leads to redistribution to larger minor radius rather than loss from the plasma. Edge and divertor plasma modeling show that about 75% of the power to the divertor can be radiated with an ITER-like divertor geometry, while over 95% can be radiated in a stable detached mode with an orthogonal target and wide slot geometry. The bootstrap current fraction is 91% with a q95 of 4.5, requiring about ~ 1.1 MA of external current drive. This current is supplied with 5 MW of ICRF/FW and 40 MW of LHCD. EC was examined and is most effective for safety factor control over ? ~ 0.2-0.6 with 20 MW. The pedestal density is ~ 0.9x1020 /m3 and the temperature is ~ 4.4 keV. The H98 factor is 1.65, n/nGr = 1.0, and the net power to LH threshold power is 2.8- 3.0 in the flattop.

  12. Development of Advanced Concept for Shortening Construction Period of ABWR Plant

    SciTech Connect (OSTI)

    Hiroshi Ijichi; Toshio Yamashita; Masahiro Tsutagawa; Hiroya Mori [Toshiba Corporation (Japan); Nobuaki Ooshima; Jun Miura [Hitachi Ltd. (Japan); Minoru Kanechika [Kajima Corporation (Japan); Nobuaki Miura [Shimizu Corporation (Japan)

    2002-07-01T23:59:59.000Z

    Construction of a nuclear power plant (NPP) requires a very long period because of large amount of construction materials and many issues for negotiation among multiple sections. Shortening the construction period advances the date of return on an investment, and can also result in reduced construction cost. Therefore, the study of this subject has a very high priority for utilities. We achieved a construction period of 37 months from the first concrete work to fuel loading (F/L) (51.5 months from the inspection of the foundation (I/F) to the start of commercial operation (C/O)) at the Kashiwazaki-Kariwa NPPs No. 6 and 7 (KK-6/7), which are the first ABWR plants in the world. At TEPCO's next plant, we think that a construction period of less than 36 months (45 months from I/F to C/O) can be realized based on conventional methods such as early start of equipment installation and blocking of equipment to be brought in advance. Furthermore, we are studying the feasibility of a 21.5-month construction period (30 months from I/F to C/O) with advanced ideas and methods. The important concepts for a 21.5-month construction period are adoption of a new building structure that is the steel plate reinforced concrete (SC) structure and promotion of extensive modularization of equipment and building structure. With introducing these new concepts, we are planning the master schedule (M/S) and finding solutions to conflicts in the schedule of area release from building construction work to equipment installation work (schedule-conflicts.) In this report, we present the shortest construction period and an effective method to put it into practice for the conventional general arrangement (GA) of ABWR. In the future, we will continue the study on the improvement of building configuration and arrangements, and make clear of the concept for large composite modules of building structures and equipment. (authors)

  13. Improving energy efficiency in a pharmaceutical manufacturing environment -- production facility

    E-Print Network [OSTI]

    Zhang, Endong, M. Eng. Massachusetts Institute of Technology

    2009-01-01T23:59:59.000Z

    The manufacturing plant of a pharmaceutical company in Singapore had low energy efficiency in both its office buildings and production facilities. Heating, Ventilation and Air-Conditioning (HVAC) system was identified to ...

  14. Advanced virtual energy simulation training and research: IGCC with CO2 capture power plant

    SciTech Connect (OSTI)

    Zitney, S.; Liese, E.; Mahapatra, P.; Bhattacharyya, D.; Provost, G.

    2011-01-01T23:59:59.000Z

    In this presentation, we highlight the deployment of a real-time dynamic simulator of an integrated gasification combined cycle (IGCC) power plant with CO{sub 2} capture at the Department of Energy's (DOE) National Energy Technology Laboratory's (NETL) Advanced Virtual Energy Simulation Training and Research (AVESTARTM) Center. The Center was established as part of the DOE's accelerating initiative to advance new clean coal technology for power generation. IGCC systems are an attractive technology option, generating low-cost electricity by converting coal and/or other fuels into a clean synthesis gas mixture in a process that is efficient and environmentally superior to conventional power plants. The IGCC dynamic simulator builds on, and reaches beyond, conventional power plant simulators to merge, for the first time, a 'gasification with CO{sub 2} capture' process simulator with a 'combined-cycle' power simulator. Fueled with coal, petroleum coke, and/or biomass, the gasification island of the simulated IGCC plant consists of two oxygen-blown, downward-fired, entrained-flow, slagging gasifiers with radiant syngas coolers and two-stage sour shift reactors, followed by a dual-stage acid gas removal process for CO{sub 2} capture. The combined cycle island consists of two F-class gas turbines, steam turbine, and a heat recovery steam generator with three-pressure levels. The dynamic simulator can be used for normal base-load operation, as well as plant start-up and shut down. The real-time dynamic simulator also responds satisfactorily to process disturbances, feedstock blending and switchovers, fluctuations in ambient conditions, and power demand load shedding. In addition, the full-scope simulator handles a wide range of abnormal situations, including equipment malfunctions and failures, together with changes initiated through actions from plant field operators. By providing a comprehensive IGCC operator training system, the AVESTAR Center is poised to develop a workforce well-prepared to operate and control commercial-scale gasification-based power plants capable of 90% pre-combustion CO{sub 2} capture and compression, as well as low sulfur, mercury, and NOx emissions. With additional support from the NETL-Regional University Alliance (NETL-RUA), the Center will educate and train engineering students and researchers by providing hands-on 'learning by operating' experience The AVESTAR Center also offers unique collaborative R&D opportunities in high-fidelity dynamic modeling, advanced process control, real-time optimization, and virtual plant simulation. Objectives and goals are aimed at safe and effective management of power generation systems for optimal efficiency, while protecting the environment. To add another dimension of realism to the AVESTAR experience, NETL will introduce an immersive training system with innovative three-dimensional virtual reality technology. Wearing a stereoscopic headset or eyewear, trainees will enter an interactive virtual environment that will allow them to move freely throughout the simulated 3-D facility to study and learn various aspects of IGCC plant operation, control, and safety. Such combined operator and immersive training systems go beyond traditional simulation and include more realistic scenarios, improved communication, and collaboration among co-workers.

  15. Study of Pu consumption in advanced light water reactors: Evaluation of GE advanced boiling water reactor plants - compilation of Phase 1B task reports

    SciTech Connect (OSTI)

    NONE

    1993-09-15T23:59:59.000Z

    This report contains an extensive evaluation of GE advanced boiling water reactor plants prepared for United State Department of Energy. The general areas covered in this report are: core and system performance; fuel cycle; infrastructure and deployment; and safety and environmental approval.

  16. Electrospinning for pharmaceutical applications

    E-Print Network [OSTI]

    Brettmann, Blair Kathryn

    2012-01-01T23:59:59.000Z

    The pharmaceutical industry is currently shifting from batch to continuous manufacturing, and for downstream processes, this shift can reduce costs and improve quality provided the new unit operations are chosen properly. ...

  17. The Relationship Between Pharmaceutical Companies and Physicians

    E-Print Network [OSTI]

    Aggarwal, Khushbu

    2010-01-01T23:59:59.000Z

    Faculty and the Pharmaceutical Industry: One Medical School’Physicians and the Pharmaceutical Industry: Is a Gift Everfunds from the pharmaceutical industry to survive in the

  18. The Next Generation Nuclear Plant/Advanced Gas Reactor Fuel Irradiation Experiments in the Advanced Test Reactor

    SciTech Connect (OSTI)

    S. Blaine Grover

    2009-09-01T23:59:59.000Z

    The United States Department of Energy’s Next Generation Nuclear Plant (NGNP) Program will be irradiating eight separate low enriched uranium (LEU) tri-isotopic (TRISO) particle fuel (in compact form) experiments in the Advanced Test Reactor (ATR) located at the Idaho National Laboratory (INL). The ATR has a long history of irradiation testing in support of reactor development and the INL has been designated as the new United States Department of Energy’s lead laboratory for nuclear energy development. The ATR is one of the world’s premiere test reactors for performing long term, high flux, and/or large volume irradiation test programs. These irradiations and fuel development are being accomplished to support development of the next generation reactors in the United States, and will be irradiated over the next ten years to demonstrate and qualify new particle fuel for use in high temperature gas reactors. The goals of the irradiation experiments are to provide irradiation performance data to support fuel process development, to qualify fuel for normal operating conditions, to support development and validation of fuel performance and fission product transport models and codes, and to provide irradiated fuel and materials for post irradiation examination (PIE) and safety testing. The experiments, which will each consist of at least six separate capsules, will be irradiated in an inert sweep gas atmosphere with individual on-line temperature monitoring and control of each capsule. The sweep gas will also have on-line fission product monitoring on its effluent to track performance of the fuel in each individual capsule during irradiation. The first experiment (designated AGR-1) started irradiation in December 2006, and the second experiment (AGR-2) is currently in the design phase. The design of test trains, as well as the support systems and fission product monitoring system that will monitor and control the experiment during irradiation will be discussed. In addition, the purpose and differences between the two experiments will be compared and the irradiation results to date on the first experiment will be presented.

  19. Advancing the Deployment of Utility-Scale Photovoltaic Plants in the Northeast

    SciTech Connect (OSTI)

    Lofaro R.; Villaran, M; Colli, A.

    2012-06-03T23:59:59.000Z

    As one of the premier research laboratories operated by the Department of Energy, Brookhaven National Laboratory (BNL) is pursuing an energy research agenda that focuses on renewable energy systems and will help to secure the nation's energy security. A key element of the BNL research is the advancement of grid-connected utility-scale solar photovoltaic (PV) plants, particularly in the northeastern part of the country where BNL is located. While a great deal of information has been generated regarding solar PV systems located in mostly sunny, hot, arid climates of the southwest US, very little data is available to characterize the performance of these systems in the cool, humid, frequently overcast climates experienced in the northeastern portion of the country. Recognizing that there is both a need and a market for solar PV generation in the northeast, BNL is pursuing research that will advance the deployment of this important renewable energy resource. BNL's research will leverage access to unique time-resolved data sets from the 37MWp solar array recently developed on its campus. In addition, BNL is developing a separate 1MWp solar research array on its campus that will allow field testing of new PV system technologies, including solar modules and balance of plant equipment, such as inverters, energy storage devices, and control platforms. These research capabilities will form the cornerstone of the new Northeast Solar Energy Research Center (NSERC) being developed at BNL. In this paper, an overview of BNL's energy research agenda is given, along with a description of the 37MWp solar array and the NSERC.

  20. Rebuttal: Interacting With the Pharmaceutical Industry

    E-Print Network [OSTI]

    Stone, Susan; Herbert, Mel

    2003-01-01T23:59:59.000Z

    9. 6. Angell M. The pharmaceutical industry: To whom is ithas shown that the pharmaceutical industry has profited some

  1. SiC/SiC Composite for an Advanced Fusion Power Plant Blanket A. R. Raffray1

    E-Print Network [OSTI]

    SiC/SiC Composite for an Advanced Fusion Power Plant Blanket A. R. Raffray1 , L. El-Guebaly2 , D. K, and constraints relating to the SiC/SiC properties are discussed. INTRODUCTION The use of SiC/SiC composite

  2. Advanced regulatory control and coordinated plant-wide control strategies for IGCC targeted towards improving power ramp-rates

    SciTech Connect (OSTI)

    Mahapatra, P.; Zitney, S.

    2012-01-01T23:59:59.000Z

    As part of ongoing R&D activities at the National Energy Technology Laboratory's (NETL) Advanced Virtual Energy Simulation Training & Research (AVESTAR™) Center, this paper highlights strategies for enhancing low-level regulatory control and system-wide coordinated control strategies implemented in a high-fidelity dynamic simulator for an Integrated Gasification Combined Cycle (IGCC) power plant with carbon capture. The underlying IGCC plant dynamic model contains 20 major process areas, each of which is tightly integrated with the rest of the power plant, making individual functionally-independent processes prone to routine disturbances. Single-loop feedback control although adequate to meet the primary control objective for most processes, does not take into account in advance the effect of these disturbances, making the entire power plant undergo large offshoots and/or oscillations before the feedback action has an opportunity to impact control performance. In this paper, controller enhancements ranging from retuning feedback control loops, multiplicative feed-forward control and other control techniques such as split-range control, feedback trim and dynamic compensation, applicable on various subsections of the integrated IGCC plant, have been highlighted and improvements in control responses have been given. Compared to using classical feedback-based control structure, the enhanced IGCC regulatory control architecture reduces plant settling time and peak offshoots, achieves faster disturbance rejection, and promotes higher power ramp-rates. In addition, improvements in IGCC coordinated plant-wide control strategies for “Gasifier-Lead”, “GT-Lead” and “Plantwide” operation modes have been proposed and their responses compared. The paper is concluded with a brief discussion on the potential IGCC controller improvements resulting from using advanced process control, including model predictive control (MPC), as a supervisory control layer.

  3. Qualification issues associated with the use of advanced instrumentation and control systems hardware in nuclear power plants

    SciTech Connect (OSTI)

    Korsah, K. [Oak Ridge National Lab., TN (United States); Antonescu, C. [Nuclear Regulatory Commission, Rockville, MD (United States). Office of Nuclear Regulatory Research

    1993-10-01T23:59:59.000Z

    The instrumentation and control (I&C) systems in advanced reactors will make extensive use of digital controls, microprocessors, multiplexing, and Tiber-optic transmission. Elements of these advances in I&C have been implemented on some current operating plants. However, the widespread use of the above technologies, as well as the use of artificial intelligence with minimum reliance on human operator control of reactors, highlights the need to develop standards for qualifying I&C used in the next generation of nuclear power plants. As a first step in this direction, the protection system I&C for present-day plants was compared to that proposed for advanced light water reactors (ALWRs). An evaluation template was developed by assembling a configuration of a safety channel instrument string for a generic ALWR, then comparing the impact of environmental stressors on that string to their effect on an equivalent instrument string from an existing light water reactor. The template was then used to address reliability issues for microprocessor-based protection systems. Standards (or lack thereof) for the qualification of microprocessor-based safety I&C systems were also identified. This approach addresses in part issues raised in Nuclear Regulatory Commission policy document SECY-91-292. which recognizes that advanced I&C systems for the nuclear industry are ``being developed without consensus standards, as the technology available for design is ahead of the technology that is well understood through experience and supported by application standards.``

  4. Analysis of the effectiveness of gas centrifuge enrichment plants advanced safeguards

    SciTech Connect (OSTI)

    Boyer, Brian David [Los Alamos National Laboratory; Erpenbeck, Heather H [Los Alamos National Laboratory; Miller, Karen A [Los Alamos National Laboratory; Swinjoe, Martyn T [Los Alamos National Laboratory; Ianakiev, Kiril D [Los Alamos National Laboratory; Marlow, Johnna B [Los Alamos National Laboratory

    2010-01-01T23:59:59.000Z

    Current safeguards approaches used by the International Atomic Energy Agency (IAEA) at gas centrifuge enrichment plants (GCEPs) need enhancement in order to verify declared low-enriched uranium (LEU) production, detect undeclared LEU production and detect highly enriched uranium (HEU) production with adequate detection probability using non destructive assay (NDA) techniques. At present inspectors use attended systems, systems needing the presence of an inspector for operation, during inspections to verify the mass and 235U enrichment of declared UF6 containers used in the process of enrichment at GCEPs. This paper contains an analysis of possible improvements in unattended and attended NDA systems including process monitoring and possible on-site destructive assay (DA) of samples that could reduce the uncertainty of the inspector's measurements. These improvements could reduce the difference between the operator's and inspector's measurements providing more effective and efficient IAEA GCEPs safeguards. We also explore how a few advanced safeguards systems could be assembled for unattended operation. The analysis will focus on how unannounced inspections (UIs), and the concept of information-driven inspections (IDS) can affect probability of detection of the diversion of nuclear materials when coupled to new GCEPs safeguards regimes augmented with unattended systems.

  5. Gas centrifuge enrichment plants inspection frequency and remote monitoring issues for advanced safeguards implementation

    SciTech Connect (OSTI)

    Boyer, Brian David [Los Alamos National Laboratory; Erpenbeck, Heather H [Los Alamos National Laboratory; Miller, Karen A [Los Alamos National Laboratory; Ianakiev, Kiril D [Los Alamos National Laboratory; Reimold, Benjamin A [Los Alamos National Laboratory; Ward, Steven L [Los Alamos National Laboratory; Howell, John [GLASGOW UNIV.

    2010-09-13T23:59:59.000Z

    Current safeguards approaches used by the IAEA at gas centrifuge enrichment plants (GCEPs) need enhancement in order to verify declared low enriched uranium (LEU) production, detect undeclared LEU production and detect high enriched uranium (BEU) production with adequate probability using non destructive assay (NDA) techniques. At present inspectors use attended systems, systems needing the presence of an inspector for operation, during inspections to verify the mass and {sup 235}U enrichment of declared cylinders of uranium hexafluoride that are used in the process of enrichment at GCEPs. This paper contains an analysis of how possible improvements in unattended and attended NDA systems including process monitoring and possible on-site destructive analysis (DA) of samples could reduce the uncertainty of the inspector's measurements providing more effective and efficient IAEA GCEPs safeguards. We have also studied a few advanced safeguards systems that could be assembled for unattended operation and the level of performance needed from these systems to provide more effective safeguards. The analysis also considers how short notice random inspections, unannounced inspections (UIs), and the concept of information-driven inspections can affect probability of detection of the diversion of nuclear material when coupled to new GCEPs safeguards regimes augmented with unattended systems. We also explore the effects of system failures and operator tampering on meeting safeguards goals for quantity and timeliness and the measures needed to recover from such failures and anomalies.

  6. Advances

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth (AOD)ProductssondeadjustsondeadjustAbout the BuildingInnovation PortalScienceScripting forAdvances in

  7. Engineering Pharmaceutical Nanoparticles

    E-Print Network [OSTI]

    Berkland, Cory

    2006-10-26T23:59:59.000Z

    enough to enter cells. Particle size >200 nm enables intracellular delivery. www.genovis.com 6 Particle engineering is critical for pharmaceutical applications. ? Dissolution rate #0;z Control size ? Pulmonary delivery #0;z ~3 microns ? Nasal... delivery #0;z ~5-20 microns ? Embolism #0;z ~10-20 microns ? Avoid RES #0;z >150 nm ? Target ?leaky? vessels #0;z <250 nm ? Endocytosis #0;z ~200 nm #0;z Control particle? ? Size and distribution ? Morphology ? Surface roughness #0;z Dispersibility...

  8. Mirror Advanced Reactor Study (MARS). Final report. Volume 1-B. Commercial fusion electric plant

    SciTech Connect (OSTI)

    Donohue, M.L.; Price, M.E. (eds.)

    1984-07-01T23:59:59.000Z

    Volume 1-B contains the following chapters: (1) blanket and reflector; (2) central cell shield; (3) central cell structure; (4) heat transport and energy conversion; (5) tritium systems; (6) cryogenics; (7) maintenance; (8) safety; (9) radioactivity, activation, and waste disposal; (10) instrumentation and control; (11) balance of plant; (12) plant startup and operation; (13) plant availability; (14) plant construction; and (15) economic analysis.

  9. The Pfizer Institute for Pharmaceutical Materials Science The Pfizer Institute for Pharmaceutical

    E-Print Network [OSTI]

    Lasenby, Joan

    and exacting process and the pharmaceutical industry strives to increase efficiency and productivityThe Pfizer Institute for Pharmaceutical Materials Science The Pfizer Institute for Pharmaceutical Materials Science #12;The Pfizer Institute for Pharmaceutical Materials Science Modelling and Experimental

  10. Sponsored by Stevens Pharmaceutical Center and AIChE The Pharmaceutical Industry /

    E-Print Network [OSTI]

    Fisher, Frank

    Sponsored by Stevens Pharmaceutical Center and AIChE The Pharmaceutical Industry / Academia discuss the educational and technical skills needed by the Pharmaceutical industry and how Universities & Bioanalytical Development Pharmaceutical Development, Bristol-Myers Squibb Company ABSTRACT Dr. Scypinski

  11. Process systems engineering of continuous pharmaceutical manufacturing

    E-Print Network [OSTI]

    Abel, Matthew J

    2010-01-01T23:59:59.000Z

    Continuous manufacturing offers a number of operational and financial benefits to pharmaceutical companies. This research examines the critical blending step for continuous pharmaceutical manufacturing and the characteristics ...

  12. Development of a Multi-Step Synthesis and Workup Sequence for an Integrated, Continuous Manufacturing Process of a Pharmaceutical

    E-Print Network [OSTI]

    Heider, Patrick L.

    The development and operation of the synthesis and workup steps of a fully integrated, continuous manufacturing plant for synthesizing aliskiren, a small molecule pharmaceutical, are presented. The plant started with ...

  13. Impact of Advanced Turbine Systems on coal-based power plants

    SciTech Connect (OSTI)

    Bechtel, T.F.

    1993-12-31T23:59:59.000Z

    The advanced power-generation products currently under development in our program show great promise for ultimate commercial use. Four of these products are referred to in this paper: Integrated Gasification Combined Cycle (IGCC), Pressurized Fluidized Bed Combustion (PFBC), Externally Fired Combined Cycle (EFCC), and Integrated Gasification Fuel Cell (IGFC). Three of these products, IGCC, PFBC, and EFCC, rely on advanced gas turbines as a key enabling technology and the foundation for efficiencies in the range of 52 to 55 percent. DOE is funding the development of advanced gas turbines in the newly instituted Advanced Turbine Systems (ATS) Program, one of DOE`s highest priority natural gas initiatives. The turbines, which will have natural gas efficiencies of 60 percent, are being evaluated for coal gas compatibility as part of that program.

  14. Advanced Condenser Boosts Geothermal Power Plant Output (Fact Sheet), The Spectrum of Clean Energy Innovation

    SciTech Connect (OSTI)

    Not Available

    2010-12-01T23:59:59.000Z

    When power production at The Geysers geothermal power complex began to falter, the National Renewable Energy Laboratory (NREL) stepped in, developing advanced condensing technology that dramatically boosted production efficiency - and making a major contribution to the effective use of geothermal power. NREL developed advanced direct-contact condenser (ADCC) technology to condense spent steam more effectively, improving power production efficiency in Unit 11 by 5%.

  15. The study of inventory management of raw materials for a pharmaceutical company

    E-Print Network [OSTI]

    Khor, Si Ming Thomas

    2007-01-01T23:59:59.000Z

    TCG is a multinational pharmaceutical company. As part of its drive to adopt lean manufacturing methodology in the plant and to stay competitive in the industry, TCG plans to effectively maximize its capital assets and ...

  16. Introduction The essence of pharmaceutical materi-

    E-Print Network [OSTI]

    Elliott, James

    , crystalline, and amorphous materials of relevance to the pharmaceutical industry. Like its parent discipline of pharmaceutical dosage forms. However, it was not until the early 1950s that the pharmaceutical industry beganIntroduction The essence of pharmaceutical materi- als science is the application of fundamen- tal

  17. Modeling Creep-Fatigue-Environment Interactions in Steam Turbine Rotor Materials for Advanced Ultra-supercritical Coal Power Plants

    SciTech Connect (OSTI)

    Shen, Chen

    2014-01-20T23:59:59.000Z

    The goal of this project is to model creep-fatigue-environment interactions in steam turbine rotor materials for advanced ultra-supercritical (A-USC) coal power Alloy 282 plants, to develop and demonstrate computational algorithms for alloy property predictions, and to determine and model key mechanisms that contribute to the damages caused by creep-fatigue-environment interactions. The nickel based Alloy 282 is selected for this project because it is one of the leading candidate materials for the high temperature/pressure section of an A-USC steam turbine. The methods developed in the project are expected to be applicable to other metal alloys in similar steam/oxidation environments. The major developments are: ? failure mechanism and microstructural characterization ? atomistic and first principles modeling of crack tip oxygen embrittlement ? modeling of gamma prime microstructures and mesoscale microstructure-defect interactions ? microstructure and damage-based creep prediction ? multi-scale crack growth modeling considering oxidation, viscoplasticity and fatigue The technology developed in this project is expected to enable more accurate prediction of long service life of advanced alloys for A-USC power plants, and provide faster and more effective materials design, development, and implementation than current state-of-the-art computational and experimental methods. This document is a final technical report for the project, covering efforts conducted from January 2011 to January 2014.

  18. Advanced Power Ultra-Uprates of Existing Plants (APPU) Final Scientific/Technical Report

    SciTech Connect (OSTI)

    Rubiolo, Pablo R.; Conway, Lawarence E.; Oriani, Luca; Lahoda, Edward J.; DeSilva, Greg (Westinghouse Science and Technology Department); Hu, Min H.; Hartz, Josh; Bachrach, Uriel; Smith, Larry; Dudek, Daniel F. (Westinghouse Nuclear Services Division); Toman, Gary J, (Electric Power Research Institute); Feng, Dandong; Hejzlar, Pavel; Kazimi, Mujid S. (Massachusetts Institute of Technology)

    2006-03-31T23:59:59.000Z

    This project assessed the feasibility of a Power Ultra-Uprate on an existing nuclear plant. The study determined the technical and design limitations of the current components, both inside and outside the containment. Based on the identified plant bottlenecks, the design changes for major pieces of equipment required to meet the Power Ultra-Uprate throughput were determined. Costs for modified pieces of equipment and for change-out and disposal of the replaced equipment were evaluated. These costs were then used to develop capital, fuel and operating and maintenance cost estimates for the Power Ultra-Uprate plant. The cost evaluation indicates that the largest cost components are the replacement of power (during the outage required for the uprate) and the new fuel loading. Based on these results, the study concluded that, for a ?standard? 4-loop plant, the proposed Power Ultra-Uprate is technically feasible. However, the power uprate is likely to be more expensive than the cost (per Kw electric installed) of a new plant when large capacity uprates are considered (>25%). Nevertheless, the concept of the Power Ultra-Uprate may be an attractive option for specific nuclear power plants where a large margin exists in the steam and power conversion system or where medium power increases (~600 MWe) are needed. The results of the study suggest that development efforts on fuel technologies for current nuclear power plants should be oriented towards improving the fuel performance (fretting-wear, corrosion, uranium load, manufacturing, safety) required to achieve higher burnup rather focusing on potential increases in the fuel thermal output.

  19. Endocrine Active Chemicals, Pharmaceuticals, and Other Chemicals of Concern in Surface Water, Wastewater-

    E-Print Network [OSTI]

    , Wastewater- Treatment Plant Effluent, and Bed Sediment, and Biological Characteristics in Selected Streams Chemicals, Pharmaceuticals, and Other Chemicals of Concern in Surface Water, Wastewater- Treatment Plant, and Data, 2009 #12;Front cover. Industrial wastewater-treatment plant outflow in Worthington, Minnesota

  20. Proceedings of the 2012 International Congress on Advances in National Power Plants - ICAPP '12

    SciTech Connect (OSTI)

    NONE

    2012-07-01T23:59:59.000Z

    ICAPP '12 provides a forum for leaders of the nuclear industry to exchange information, present results from their work, review the state of the industry, and discuss future directions and needs for the deployment of new nuclear power plant systems around the world. These proceedings gather 326 papers covering the following topics: 1. Water-Cooled Reactor Programs; 2. High Temperature Gas Cooled Reactors; 3. LMFR and Innovative Reactor Programs; 4. Operation, Performance and Reliability Management; 5. Plant Safety Assessment and Regulatory Issues; 6. Reactor Physics and Analysis; 7. Thermal Hydraulics Analysis and Testing; 8. Fuel Cycle and Waste Management; 9. Materials and Structural Issues; 10. Nuclear Energy and Global Environment; 11. Deployment and Cross-Cutting Issues; 12. Plant Licensing and International Regulatory Issues.

  1. JB RISOE 20-05-2003 Advanced 700C PF Power Plant

    E-Print Network [OSTI]

    prices of imported coal · Security of supply is threatened without coal · Clean Coal Technology in efficiency of Elsam's coal-fired power plants 1950 19701960 19901980 20202000 2010 30 32 34 36 38 40 42 44 46 of Coal Based Power Generation · Abundant reserves · Many independent producers of coal · Low and stable

  2. Development of Advanced Technologies to Reduce Design, Fabrication and Construction Costs for Future Nuclear Power Plants

    SciTech Connect (OSTI)

    Camillo A. DiNunzio Framatome ANP DE& S; Dr. Abhinav Gupta Assistant Professor NCSU; Dr. Michael Golay Professor MIT Dr. Vincent Luk Sandia National Laboratories; Rich Turk Westinghouse Electric Company Nuclear Systems; Charles Morrow, Sandia National Laboratories; Geum-Taek Jin, Korea Power Engineering Company Inc.

    2002-11-30T23:59:59.000Z

    OAK-B135 This report presents a summation of the third and final year of a three-year investigation into methods and technologies for substantially reducing the capital costs and total schedule for future nuclear plants. In addition, this is the final technical report for the three-year period of studies.

  3. Advanced Multi-Product Coal Utilization By-Product Processing Plant

    SciTech Connect (OSTI)

    John Groppo; Thomas Robl

    2006-09-30T23:59:59.000Z

    The objective of the project is to build a multi-product ash beneficiation plant at Kentucky Utilities 2,200-MW Ghent Generating Station, located in Carroll County, Kentucky. This part of the study includes an investigation of the secondary classification characteristics of the ash feedstock excavated from the lower ash pond at Ghent Station.

  4. Pharmaceutical Companies and Patient Care – The Mixed Effects Model

    E-Print Network [OSTI]

    Gururangan, Kapil

    2012-01-01T23:59:59.000Z

    Print. [17] Pharmaceutical Industry Profile. Publication.Changes in Pharmaceutical Industry. ” Health Affairs 29.7 (In Global Health: A Pharmaceutical Industry Perspective. ”

  5. Pharmaceutical Industry Sponsorship and Research Outcome and Quality: Systematic Review

    E-Print Network [OSTI]

    Lexchin, Joel; Bero, Lisa A. Ph.D.; Djulbegovic, Benjamin; Clark, Otavio

    2003-01-01T23:59:59.000Z

    D. Impact of pharmaceutical industry funding of clinicalPapers Pharmaceutical industry sponsorship and researchstudies by the pharmaceutical industry is associated with

  6. Vertical Integration and Market Entry in the Generic Pharmaceutical Industry

    E-Print Network [OSTI]

    Kubo, Kensuke

    2011-01-01T23:59:59.000Z

    in the Generic Pharmaceutical Industry . 2.2.1 Marketingin the Generic Pharmaceutical Industry 3.4 EconometricIntegration in the Generic Pharmaceutical Industry 2.1

  7. Advanced Light Water Reactor Plants System 80+{trademark} Design Certification Program. Annual progress report, October 1, 1992--September 30, 1993

    SciTech Connect (OSTI)

    Not Available

    1993-12-31T23:59:59.000Z

    The purpose of this report is to provide a status of the progress that was made towards Design Certification of System 80+{trademark} during the US government`s 1993 fiscal year. The System 80+ Advanced Light Water Reactor (ALWR) is a 3931 MW{sub t} (1350 MWe) Pressurized Water Reactor (PWR). The design consists of an essentially complete plant. It is based on evolutionary improvements to the Standardized System 80 nuclear steam supply system in operation at Palo Verde Units 1, 2, and 3, and the Duke Power Company P-81 balance-of-plant (BOP) that was designed and partially constructed at the Cherokee plant site. The System 80/P-81 original design has been substantially enhanced to increase conformance with the EPRI ALWR Utility Requirements Document (URD). Some design enhancements incorporated in the System 80+ design are included in the four units currently under construction in the Republic of Korea. These units form the basis of the Korean standardization program. The full System 80+ standard design has been offered to the Republic of China, in response to their recent bid specification. The ABB-CE Standard Safety Analysis Report (CESSAR-DC) was submitted to the NRC and a Draft Safety Evaluation Report was issued by the NRC in October 1992. CESSAR-DC contains the technical basis for compliance with the EPRI URD for simplified emergency planning. The Nuclear Steam Supply System (NSSS) is the standard ABB-Combustion Engineering two-loop arrangement with two steam generators, two hot legs and four cold legs each with a reactor coolant pump. The System 80+ standard plant includes a sperical steel containment vessel which is enclosed in a concrete shield building, thus providing the safety advantages of a dual containment.

  8. Systems Analyses of Advanced Brayton Cycles For High Efficiency Zero Emission Plants

    SciTech Connect (OSTI)

    A. D. Rao; J. Francuz; H. Liao; A. Verma; G. S. Samuelsen

    2006-11-01T23:59:59.000Z

    Table 1 shows that the systems efficiency, coal (HHV) to power, is 35%. Table 2 summarizes the auxiliary power consumption within the plant. Thermoflex was used to simulate the power block and Aspen Plus the balance of plant. The overall block flow diagram is presented in Figure A1.3-1 and the key unit process flow diagrams are shown in subsequent figures. Stream data are given in Table A1.3-1. Equipment function specifications are provided in Tables A1.3-2 through 17. The overall plant scheme consists of a cryogenic air separation unit supplying 95% purity O{sub 2} to GE type high pressure (HP) total quench gasifiers. The raw gas after scrubbing is treated in a sour shift unit to react the CO with H{sub 2}O to form H{sub 2} and CO{sub 2}. The gas is further treated to remove Hg in a sulfided activated carbon bed. The syngas is desulfurized and decarbonized in a Selexol acid gas removal unit and the decarbonized syngas after humidification and preheat is fired in GE 7H type steam cooled gas turbines. Intermediate pressure (IP) N{sub 2} from the ASU is also supplied to the combustors of the gas turbines as additional diluent for NOx control. A portion of the air required by the ASU is extracted from the gas turbines. The plant consists of the following major process units: (1) Air Separation Unit (ASU); (2) Gasification Unit; (3) CO Shift/Low Temperature Gas Cooling (LTGC) Unit; (4) Acid Gas Removal Unit (AGR) Unit; (5) Fuel Gas Humidification Unit; (6) Carbon Dioxide Compression/Dehydration Unit; (7) Claus Sulfur Recovery/Tail Gas Treating Unit (SRU/TGTU); and (8) Power Block.

  9. Paducah and Portsmouth Sites Advance Operations at DUF6 Plants | Department

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of EnergyEnergyENERGY TAXBalanced ScorecardReactorBatteries for Advanced P -Major DOEEnergyof Energy

  10. Improving central heating plant performance at the defense construction supply center (DCSC): Advanced operation and maintenance methods. Final report

    SciTech Connect (OSTI)

    Savoie, M.J.; Standerfer, J.; Schmidt, C.M.; Gostich, J.; Mignacca, J.

    1994-11-01T23:59:59.000Z

    A 1987 air pollution emissions test done by the U.S. Army Environmental Hygiene Agency (USAEHA) identified several problems with the central heating plant (CHP) at the Defense Construction Supply Center (DCSC), Columbus, OH. Though DCSC repaired the specified problems, improved coal specifications, and tried to reduce air infiltration, CHP performance remained at unacceptable levels. Consequently, DCSC contracted the U.S. Army Construction Engineering Research Laboratories (USACERL) to apply advanced operation and maintenance procedures to improve its combustion system. This study employed a system-wide approach to evaluate the CHP 5 fuel storage, combustion, heat distribution, and the control of air emissions. Many short-term improvements to the CHP were identified and tested. Subsequent combustion and air emissions tests revealed that the recommended improvements successfully increased CHP efficiency. Long-term improvements were also recommended to help maintain the short-term improvements.

  11. Advanced Outage and Control Center: Strategies for Nuclear Plant Outage Work Status Capabilities

    SciTech Connect (OSTI)

    Gregory Weatherby

    2012-05-01T23:59:59.000Z

    The research effort is a part of the Light Water Reactor Sustainability (LWRS) Program. LWRS is a research and development program sponsored by the Department of Energy, performed in close collaboration with industry to provide the technical foundations for licensing and managing the long-term, safe and economical operation of current nuclear power plants. The LWRS Program serves to help the US nuclear industry adopt new technologies and engineering solutions that facilitate the continued safe operation of the plants and extension of the current operating licenses. The Outage Control Center (OCC) Pilot Project was directed at carrying out the applied research for development and pilot of technology designed to enhance safe outage and maintenance operations, improve human performance and reliability, increase overall operational efficiency, and improve plant status control. Plant outage management is a high priority concern for the nuclear industry from cost and safety perspectives. Unfortunately, many of the underlying technologies supporting outage control are the same as those used in the 1980’s. They depend heavily upon large teams of staff, multiple work and coordination locations, and manual administrative actions that require large amounts of paper. Previous work in human reliability analysis suggests that many repetitive tasks, including paper work tasks, may have a failure rate of 1.0E-3 or higher (Gertman, 1996). With between 10,000 and 45,000 subtasks being performed during an outage (Gomes, 1996), the opportunity for human error of some consequence is a realistic concern. Although a number of factors exist that can make these errors recoverable, reducing and effectively coordinating the sheer number of tasks to be performed, particularly those that are error prone, has the potential to enhance outage efficiency and safety. Additionally, outage management requires precise coordination of work groups that do not always share similar objectives. Outage managers are concerned with schedule and cost, union workers are concerned with performing work that is commensurate with their trade, and support functions (safety, quality assurance, and radiological controls, etc.) are concerned with performing the work within the plants controls and procedures. Approaches to outage management should be designed to increase the active participation of work groups and managers in making decisions that closed the gap between competing objectives and the potential for error and process inefficiency.

  12. Steam Oxidation of Fossil Power Plant Materials: Collaborative Research to Enable Advanced Steam Power Cycles

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    A. T. Fry; I. G Wright; N. J Simms; B. McGhee; G. R. Holcomb

    2013-11-19T23:59:59.000Z

    Research into improved materials systems and associated manufacturing and reliability issues is a major part of initiatives to produce cleaner and cheaper energy systems in the UK and the USA. Under the auspices of a Memorandum of Understanding on Energy R&D, a work programme concerned with steam oxidation has been conducted. The focus was on the generation of definitive information regarding the oxidation behaviour in steam of current and developmental ferritic steels, austenitic steels, and nickelbased alloys required to enable advanced steam power cycles. The results were intended to provide a basis for quantifying the rate of metal loss expected under advanced steam cycle conditions, as well as understanding of the evolution of oxide scale morphologies with time and temperature to identify features that could influence scale exfoliation characteristics. This understanding and acquired data were used to develop and validate models of oxide growth and loss by exfoliation. This paper provides an overview of the activity and highlights a selection of the results coming from the programme.

  13. Commercial-Scale Performance Predictions for High-Temperature Electrolysis Plants Coupled to Three Advanced Reactor Types

    SciTech Connect (OSTI)

    M. G. McKellar; J. E. O'Brien; J. S. Herring

    2007-09-01T23:59:59.000Z

    This report presents results of system analyses that have been developed to assess the hydrogen production performance of commercial-scale high-temperature electrolysis (HTE) plants driven by three different advanced reactor – power-cycle combinations: a high-temperature helium cooled reactor coupled to a direct Brayton power cycle, a supercritical CO2-cooled reactor coupled to a direct recompression cycle, and a sodium-cooled fast reactor coupled to a Rankine cycle. The system analyses were performed using UniSim software. The work described in this report represents a refinement of previous analyses in that the process flow diagrams include realistic representations of the three advanced reactors directly coupled to the power cycles and integrated with the high-temperature electrolysis process loops. In addition, this report includes parametric studies in which the performance of each HTE concept is determined over a wide range of operating conditions. Results of the study indicate that overall thermal-to- hydrogen production efficiencies (based on the low heating value of the produced hydrogen) in the 45 - 50% range can be achieved at reasonable production rates with the high-temperature helium cooled reactor concept, 42 - 44% with the supercritical CO2-cooled reactor and about 33 - 34% with the sodium-cooled reactor.

  14. International Pharmaceutical Abstracts (IPA) What is International Pharmaceutical Abstracts?

    E-Print Network [OSTI]

    Saskatchewan, University of

    topic into the search box. #12;2 2. Click on Search to continue. 3. Enter terms to describe another in your search results. "Or" broadens your search by letting you search for related terms or synonyms. #12-related health topics. Searching International Pharmaceutical Abstracts The example below illustrates a step

  15. Assessment of instrumentation needs for advanced coal power plant applications: Final report

    SciTech Connect (OSTI)

    Nelson, E.T.; Fischer, W.H.; Lipka, J.V.; Rutkowski, M.D.; Zaharchuk, R.

    1987-10-01T23:59:59.000Z

    The purpose of this study was to identify contaminants, identify instrumentation needs, assess available instrumentation and identify instruments that should be developed for controlling and monitoring gas streams encountered in the following power plants: Integrated Gasification Combined Cycle, Pressurized Fluidized Bed Combustion, and Gasification Molten Carbonate Fuel Cell. Emphasis was placed on hot gas cleanup system gas stream analysis, and included process control, research and environmental monitoring needs. Commercial process analyzers, typical of those currently used for process control purposes, were reviewed for the purpose of indicating commercial status. No instrument selection guidelines were found which were capable of replacing user interaction with the process analyzer vendors. This study leads to the following conclusions: available process analyzers for coal-derived gas cleanup applications satisfy current power system process control and regulatory requirements, but they are troublesome to maintain; commercial gas conditioning systems and in situ analyzers continue to be unavailable for hot gas cleanup applications; many research-oriented gas stream characterization and toxicity assessment needs can not be met by commercially available process analyzers; and greater emphasis should be placed on instrumentation and control system planning for future power plant applications. Analyzers for specific compounds are not recommended other than those needed for current process control purposes. Instead, some generally useful on-line laser-based and inductively coupled plasma methods are recommended for further development because of their potential for use in present hot gas cleanup research and future optimization, component protection and regulation compliance activities. 48 refs., 21 figs., 26 tabs.

  16. Advanced Multi-Product Coal Utilization By-Product Processing Plant

    SciTech Connect (OSTI)

    Andrew Jackura; John Groppo; Thomas Robl

    2006-12-31T23:59:59.000Z

    The objective of the project is to build a multi-product ash beneficiation plant at Kentucky Utilities 2,200-MW Ghent Generating Station, located in Carroll County, Kentucky. This part of the study includes an investigation of the secondary classification characteristics of the ash feedstock excavated from the lower ash pond at Ghent Station. The market study for the products of the processing plant (Subtask 1.6), conducted by Cemex, is reported herein. The study incorporated simplifying assumptions and focused only on pozzolan and ultra fine fly ash (UFFA). It found that the market for pozzolan in the Ghent area was oversupplied, with resultant poor pricing structure. Reachable export markets for the Ghent pozzolan market were mostly locally served with the exception of Florida. It was concluded that a beneficiated material for that market may be at a long term disadvantage. The market for the UFFA was more complex as this material would compete with other beneficiated ash and potential metakaolin and silica fume as well. The study concluded that this market represented about 100,000 tons of sales per year and, although lucrative, represented a widely dispersed niche market.

  17. Farmbio2010/33 DepartmentofPharmaceutical

    E-Print Network [OSTI]

    Uppsala Universitet

    , pharmaceutical industries and the government. For example, in 2009 the Swedish council for working life that they will be able to make significant contributions in the academia and pharmaceutical industry in the future European universities and pharmaceutical industry make joint efforts to train especially employees

  18. Advanced Multi-Product Coal Utilization By-Product Processing Plant

    SciTech Connect (OSTI)

    Thomas Robl; John Groppo

    2007-03-31T23:59:59.000Z

    The objective of the project is to build a multi-product ash beneficiation plant at Kentucky Utilities 2,200-MW Ghent Generating Station, located in Carroll County, Kentucky. Phase 1 was completed successfully, but the project did not continue on to Phase 2 due to withdrawal of CEMEX from the project. Attempts at replacing CEMEX were not successful. Problematic to the continuation of the project was its location in the Ohio Valley which is oversupplied and has low prices for fly ash and the change in CEMEX priorities due to merger and acquisitions. Thus, CAER concurred with the DOE to conclude the project at the end of Budget Period 1, March 31, 2007.

  19. A two-day (11-12 April 2011) will discuss recent advances in plant genomics and will be followed by a combining lectures with practical

    E-Print Network [OSTI]

    Gent, Universiteit

    A two-day (11-12 April 2011) will discuss recent advances in plant genomics and will be followed by a combining lectures with practical sessions covering data integration, comparative genomics-gen genome sequencing genome evolution comparative transcriptomics ChIPprofiling regulatorynetworks

  20. Fate of a representative pharmaceutical in the environment

    E-Print Network [OSTI]

    Morse, Audra; Jackson, Andrew

    to the build-up of resistance in microbial populations. Antibiotics enter the environment from a variety of sources including discharges from domestic wastewater treatment plants and pharmaceutical companies, runoff from animal feeding operations, infiltration... typically range from nanogram/liter (ng/L) to microgram/liter (mg/L); the consequences of their presence at these concentrations are unknown. The overall potential for antibiotic removal by biological and physiochemical treatment systems and simultaneous...

  1. Evaluation of the applicability of existing nuclear power plant regulatory requirements in the U.S. to advanced small modular reactors.

    SciTech Connect (OSTI)

    LaChance, Jeffrey L.; Wheeler, Timothy A.; Farnum, Cathy Ottinger; Middleton, Bobby D.; Jordan, Sabina Erteza; Duran, Felicia Angelica; Baum, Gregory A.

    2013-05-01T23:59:59.000Z

    The current wave of small modular reactor (SMR) designs all have the goal of reducing the cost of management and operations. By optimizing the system, the goal is to make these power plants safer, cheaper to operate and maintain, and more secure. In particular, the reduction in plant staffing can result in significant cost savings. The introduction of advanced reactor designs and increased use of advanced automation technologies in existing nuclear power plants will likely change the roles, responsibilities, composition, and size of the crews required to control plant operations. Similarly, certain security staffing requirements for traditional operational nuclear power plants may not be appropriate or necessary for SMRs due to the simpler, safer and more automated design characteristics of SMRs. As a first step in a process to identify where regulatory requirements may be met with reduced staffing and therefore lower cost, this report identifies the regulatory requirements and associated guidance utilized in the licensing of existing reactors. The potential applicability of these regulations to advanced SMR designs is identified taking into account the unique features of these types of reactors.

  2. Operating results of the advanced ceramic tube filter (ACTF) at Wakamatus 71 MW PFBC demonstration plant

    SciTech Connect (OSTI)

    Toriyama, Akira; Higashi, Katsumi; Maeno, Hiroshi; Saito, Tsunehiro; Mori, Mineo; Hori, Junji; Tsuji, Yasujiro

    1999-07-01T23:59:59.000Z

    The ACTF installed at the 71 MWe pressurized fluidized bed combustion (PFBC) demonstration plant at Wakamatsu Power Station of Electric Power Development Co., Ltd. is featured by inside to outside gas flow configuration with vertically arranged tubes in three compartments. This unique configuration offers advantages in the gas cleaning system for high-temperature and high-pressure applications of commercial scale. During Phase-1 demonstration program in Wakamatsu completed in December 1997, the ACTF showed the outstanding performance in terms of dust removal efficiency, pressure drop stability and reliability. The accumulated operating time of the ACTF in Phase-1 reached more than 6,000 hours and the continuous operating time record for 785 hours has been established. The successful results of ACTF and PFBC in Phase-1 lead to a two-year extension of the demonstration program (Phase-2). In Phase-2, it is aimed to demonstrate the further reliability and the possibility of cost reduction of the ACTF. The modified configuration of the boiler in Phase-2 (elimination of the existing pre-cleaning cyclones, etc.) magnifies the inlet dust loading at the ACTF and it calls for modifications in the ACTF to make it feasible with inlet gas with much higher dust loading. The modification works are under way and will continue until July 1998. The test operation is planned to resume in August 1998. This paper reviews the operating results of the ACTF during Wakamatsu demonstration test Phase-1 and gives brief description of the Phase-2 program.

  3. Advanced Multi-Product Coal Utilization By-Product Processing Plant

    SciTech Connect (OSTI)

    Thomas Robl; John Groppo

    2009-06-30T23:59:59.000Z

    The overall objective of this project is to design, construct, and operate an ash beneficiation facility that will generate several products from coal combustion ash stored in a utility ash pond. The site selected is LG&E's Ghent Station located in Carroll County, Kentucky. The specific site under consideration is the lower ash pond at Ghent, a closed landfill encompassing over 100 acres. Coring activities revealed that the pond contains over 7 million tons of ash, including over 1.5 million tons of coarse carbon and 1.8 million tons of fine (<10 {micro}m) glassy pozzolanic material. These potential products are primarily concentrated in the lower end of the pond adjacent to the outlet. A representative bulk sample was excavated for conducting laboratory-scale process testing while a composite 150 ton sample was also excavated for demonstration-scale testing at the Ghent site. A mobile demonstration plant with a design feed rate of 2.5 tph was constructed and hauled to the Ghent site to evaluate unit processes (i.e. primary classification, froth flotation, spiral concentration, secondary classification, etc.) on a continuous basis to determine appropriate scale-up data. Unit processes were configured into four different flowsheets and operated at a feed rate of 2.5 tph to verify continuous operating performance and generate bulk (1 to 2 tons) products for product testing. Cementitious products were evaluated for performance in mortar and concrete as well as cement manufacture process addition. All relevant data from the four flowsheets was compiled to compare product yields and quality while preliminary flowsheet designs were generated to determine throughputs, equipment size specifications and capital cost summaries. A detailed market study was completed to evaluate the potential markets for cementitious products. Results of the study revealed that the Ghent local fly ash market is currently oversupplied by more than 500,000 tpy and distant markets (i.e. Florida) are oversupplied as well. While the total US demand for ultrafine pozzolan is currently equal to demand, there is no reason to expect a significant increase in demand. Despite the technical merits identified in the pilot plant work with regard to beneficiating the entire pond ash stream, market developments in the Ohio River Valley area during 2006-2007 were not conducive to demonstrating the project at the scale proposed in the Cooperative Agreement. As a result, Cemex withdrew from the project in 2006 citing unfavorable local market conditions in the foreseeable future at the demonstration site. During the Budget Period 1 extensions provided by the DOE, CAER has contacted several other companies, including cement producers and ash marketing concerns for private cost share. Based on the prevailing demand-supply situation, these companies had expressed interest only in limited product lines, rather than the entire ash beneficiation product stream. Although CAER had generated interest in the technology, a financial commitment to proceed to Budget Period 2 could not be obtained from private companies. Furthermore, the prospects of any decisions being reached within a reasonable time frame were dim. Thus, CAER concurred with the DOE to conclude the project at the end of Budget Period 1, March 31, 2007. The activities presented in this report were carried out during the Cooperative Agreement period 08 November 2004 through 31 March 2007.

  4. advanced ceramics advanced: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  5. Design of the Next Generation Nuclear Plant Graphite Creep Experiments for Irradiation in the Advanced Test Reactor

    SciTech Connect (OSTI)

    S. Blaine Grover

    2009-05-01T23:59:59.000Z

    The United States Department of Energy’s Next Generation Nuclear Plant (NGNP) Program will be irradiating six gas reactor graphite creep experiments in the Advanced Test Reactor (ATR) located at the Idaho National Laboratory (INL). The ATR has a long history of irradiation testing in support of reactor development and the INL has been designated as the new United States Department of Energy’s lead laboratory for nuclear energy development. The ATR is one of the world’s premiere test reactors for performing long term, high flux, and/or large volume irradiation test programs. These graphite irradiations are being accomplished to support development of the next generation reactors in the United States. The graphite experiments will be irradiated over the next six to eight years to support development of a graphite irradiation performance data base on the new nuclear grade graphites now available for use in high temperature gas reactors. The goals of the irradiation experiments are to obtain irradiation performance data at different temperatures and loading conditions to support design of the Next Generation Nuclear Plant Very High Temperature Gas Reactor, as well as other future gas reactors. The experiments will each consist of a single capsule that will contain seven separate stacks of graphite specimens. Six of the specimen stacks will have half of their graphite specimens under a compressive load, while the other half of the specimens will not be subjected to a compressive load during irradiation. The six stacks will be organized into pairs with a different compressive load being applied to the top half of each pair of specimen stacks. The seventh stack will not have a compressive load on the graphite specimens during irradiation. The specimens will be irradiated in an inert sweep gas atmosphere with on-line temperature and compressive load monitoring and control. There will also be the capability of sampling the sweep gas effluent to determine if any oxidation or off-gassing of the specimens occurs during initial start-up of the experiment. The final design phase for the first experiment was completed in September 2008, and the fabrication and assembly of the experiment test train as well as installation and testing of the control and support systems that will monitor and control the experiment during irradiation are being completed in early calendar 2009. The first experiment is scheduled to be ready for insertion in the ATR by April 30, 2009. This paper will discuss the design of the experiment including the test train and the temperature and compressive load monitoring, control, and data collection systems.

  6. NRC review of Electric Power Research Institute`s advanced light water reactor utility requirements document. Passive plant designs, chapter 1, project number 669

    SciTech Connect (OSTI)

    Not Available

    1994-08-01T23:59:59.000Z

    The Electric Power Research Institute (EPRI) is preparing a compendium of technical requirements, referred to as the {open_quotes}Advanced Light Water Reactor [ALWR] Utility Requirements Document{close_quotes}, that is acceptable to the design of an ALWR power plant. When completed, this document is intended to be a comprehensive statement of utility requirements for the design, construction, and performance of an ALWR power plant for the 1990s and beyond. The Requirements Document consists of three volumes. Volume 1, {open_quotes}ALWR Policy and Summary of Top-Tier Requirements{close_quotes}, is a management-level synopsis of the Requirements Document, including the design objectives and philosophy, the overall physical configuration and features of a future nuclear plant design, and the steps necessary to take the proposed ALWR design criteria beyond the conceptual design state to a completed, functioning power plant. Volume II consists of 13 chapters and contains utility design requirements for an evolutionary nuclear power plant [approximately 1350 megawatts-electric (MWe)]. Volume III contains utility design requirements for nuclear plants for which passive features will be used in their designs (approximately 600 MWe). In April 1992, the staff of the Office of Nuclear Reactor Regulation, U.S. Nuclear Regulatory Commission, issued Volume 1 and Volume 2 (Parts 1 and 2) of its safety evaluation report (SER) to document the results of its review of Volumes 1 and 2 of the Requirements Document. Volume 1, {open_quotes}NRC Review of Electric Power Research Institute`s Advanced Light Water Reactor Utility Requirements Document - Program Summary{close_quotes}, provided a discussion of the overall purpose and scope of the Requirements Document, the background of the staff`s review, the review approach used by the staff, and a summary of the policy and technical issues raised by the staff during its review.

  7. NRC review of Electric Power Research Institute`s advanced light water reactor utility requirements document. Passive plant designs, chapters 2-13, project number 669

    SciTech Connect (OSTI)

    Not Available

    1994-08-01T23:59:59.000Z

    The Electric Power Research Institute (EPRI) is preparing a compendium of technical requirements, referred to as the {open_quotes}Advanced Light Water Reactor [ALWR] Utility Requirements Document{close_quotes}, that is acceptable to the design of an ALWR power plant. When completed, this document is intended to be a comprehensive statement of utility requirements for the design, construction, and performance of an ALWR power plant for the 1990s and beyond. The Requirements Document consists of three volumes. Volume I, {open_quotes}ALWR Policy and Summary of Top-Tier Requirements{close_quotes}, is a management-level synopsis of the Requirements Document, including the design objectives and philosophy, the overall physical configuration and features of a future nuclear plant design, and the steps necessary to take the proposed ALWR design criteria beyond the conceptual design state to a completed, functioning power plant. Volume II consists of 13 chapters and contains utility design requirements for an evolutionary nuclear power plant [approximately 1350 megawatts-electric (MWe)]. Volume III contains utility design requirements for nuclear plants for which passive features will be used in their designs (approximately 600 MWe). In April 1992, the staff of the Office of Nuclear Reactor Regulation, U.S. Nuclear Regulatory Commission, issued Volume 1 and Volume 2 (Parts 1 and 2) of its safety evaluation report (SER) to document the results of its review of Volumes 1 and 2 of the Requirements Document. Volume 1, {open_quotes}NRC Review of Electric Power Research Institute`s Advanced Light Water Reactor Utility Requirements Document - Program Summary{close_quotes}, provided a discussion of the overall purpose and scope of the Requirements Document, the background of the staff`s review, the review approach used by the staff, and a summary of the policy and technical issues raised by the staff during its review.

  8. Emerging Concepts of Pharmaceutical Research Funding

    E-Print Network [OSTI]

    Moeller, Ralf

    and the pharmaceutical industry to foster development of products that are highly beneficial for a larger partEmerging Concepts of Pharmaceutical Research Funding For a More Sustainable Society March 18th 2014 drawback is the lack of motivation to develop products targeted towards regions outside industrialized

  9. Virtually simulating the next generation of clean energy technologies: NETL's AVESTAR Center is dedicated to the safe, reliable and efficient operation of advanced energy plants with carbon capture

    SciTech Connect (OSTI)

    Zitney, S.

    2012-01-01T23:59:59.000Z

    Imagine using a real-time virtual simulator to learn to fly a space shuttle or rebuild your car's transmission without touching a piece of equipment or getting your hands dirty. Now, apply this concept to learning how to operate and control a state-of-the-art, electricity-producing power plant capable of carbon dioxide (CO{sub 2}) capture. That's what the National Energy Technology Laboratory's (NETL) Advanced Virtual Energy Simulation Training and Research (AVESTAR) Center (www.netl.doe.gov/avestar) is designed to do. Established as part of the Department of Energy's (DOE) initiative to advance new clean energy technology for power generation, the AVESTAR Center focuses primarily on providing simulation-based training for process engineers and energy plant operators, starting with the deployment of a first-of-a-kind operator training simulator for an integrated gasification combined cycle (IGCC) power plant with CO{sub 2} capture. The IGCC dynamic simulator builds on, and reaches beyond, conventional power plant simulators to merge, for the first time, a 'gasification with CO{sub 2} capture' process simulator with a 'combined-cycle' power simulator. Based on Invensys Operations Management's SimSci-Esscor DYNSIM software, the high-fidelity dynamic simulator provides realistic training on IGCC plant operations, including normal and faulted operations, as well as plant start-up, shutdown and power demand load changes. The highly flexible simulator also allows for testing of different types of fuel sources, such as petcoke and biomass, as well as co-firing fuel mixtures. The IGCC dynamic simulator is available at AVESTAR's two locations, NETL (Figure 1) and West Virginia University's National Research Center for Coal and Energy (www.nrcce.wvu.edu), both in Morgantown, W.Va. By offering a comprehensive IGCC training program, AVESTAR aims to develop a workforce well prepared to operate, control and manage commercial-scale gasification-based power plants with CO{sub 2} capture. The facility and simulator at West Virginia University promotes NETL's outreach mission by offering hands-on simulator training and education to researchers and university students.

  10. ADVANCED BUSINESS CERTIFICATE (ABC) HEALTH CARE FINANCE AND INSURANCE

    E-Print Network [OSTI]

    Alpay, S. Pamir

    Management (HSMG 5686) Global Healthcare Systems (HSMG 5687) Risk Management and Quality Across Borders (HSMG Management & Insurance Studies offers an Advanced Business Certificate for business professionals who, hospitals, health plans, pharmaceutical companies, long-term care facilities, physician practice management

  11. Continuous blending of dry pharmaceutical powders

    E-Print Network [OSTI]

    Pernenkil, Lakshman

    2008-01-01T23:59:59.000Z

    Conventional batch blending of pharmaceutical powders coupled with long quality analysis times increases the production cycle time leading to strained cash flows. Also, scale-up issues faced in process development causes ...

  12. Assessing the assessments: Pharmaceuticals in the environment

    SciTech Connect (OSTI)

    Enick, O.V. [Department of Biological Sciences, Simon Fraser University, Burnaby, BC, V5A 1S6 (Canada)], E-mail: oana.enick@gov.bc.ca; Moore, M.M. [Department of Biological Sciences, Simon Fraser University, Burnaby, BC, V5A 1S6 (Canada)], E-mail: mmoore@sfu.ca

    2007-11-15T23:59:59.000Z

    The relatively new issue of pharmaceutical contamination of the environment offers the opportunity to explore the application of values to the construction, communication and management of risk. The still-developing regulatory policies regarding environmental contamination with pharmaceuticals provide fertile ground for the introduction of values into the definition and management of risk. In this report, we summarize the current knowledge regarding pharmaceutical contamination of the environment and discuss specific attributes of pharmaceuticals that require special consideration. We then present an analysis showing that if values are incorporated into assessing, characterizing and managing risk, the results of risk assessments will more accurately reflect the needs of various stakeholders. Originating from an acknowledgement of the inherent uncertainty and value-laden nature of risk assessment, the precautionary principle (and later, the multi-criteria, integrated risk assessment), provides a direction for further research and policy development.

  13. Advances in Energy Efficiency, Capital Cost, and Installation Schedules for Large Capacity Cooling Applications Using a Packaged Chiller Plant Approach

    E-Print Network [OSTI]

    Pierson, T. L.; Andrepont, J. S.

    reductions in unit capital costs of installed chiller plant capacity on a dollar per ton basis, 2) marked improvements in total procurement and installation schedules, 3) significantly smaller space requirements, and 4) enhanced control over total system...

  14. Cost benefits from applying advanced heat rejection concepts to a wet/dry-cooled binary geothermal plant

    SciTech Connect (OSTI)

    Faletti, D.W.

    1981-03-01T23:59:59.000Z

    Optimized ammonia heat rejection system designs were carried out for three water allocations equivalent to 9, 20, and 31% of that of a 100% wet-cooled plant. The Holt/Procon design of a 50-MWe binary geothermal plant for the Heber site was used as a design basis. The optimization process took into account the penalties for replacement power, gas turbine capital, and lost capacity due to increased heat rejection temperature, as well as added base plant capacity and fuel to provide fan and pump power to the heat rejection system. Descriptions of the three plant designs are presented. For comparison, a wet tower loop was costed out for a 100% wet-cooled plant using the parameters of the Holt/Procon design. Wet/dry cooling was found to increase the cost of electricity by 28% above that of a 100% wet-cooled plant for all three of the water allocations studied (9, 20, and 31%). The application selected for a preconceptual evaluation of the BCT (binary cooling tower) system was the use of agricultural waste water from the New River, located in California's Imperial Valley, to cool a 50-MWe binary geothermal plant. Technical and cost evaluations at the preconceptual level indicated that performance estimates provided by Tower Systems Incorporated (TSI) were reasonable and that TSI's tower cost, although 2 to 19% lower than PNL estimates, was also reasonable. Electrical cost comparisonswere made among the BCT system, a conventional 100% wet system, and a 9% wet/dry ammonia system, all using agricultural waste water with solar pond disposal. The BCT system cost the least, yielding a cost of electricity only 13% above that of a conventional wet system using high quality water and 14% less than either the conventional 100% wet or the 9% wet/dry ammonia system.

  15. Advanced intelligent coordinated control of coal fired power plant based on fuzzy reasoning and auto-tuning

    SciTech Connect (OSTI)

    Li, S.Y.; Liu, H.B.; Cai, W.J.; Soh, Y.C.; Xie, L.H. [Shanghai Jiao Tong University, Shanghai (China)

    2004-07-01T23:59:59.000Z

    The load following operation of coal-fired boiler-turbine unit in power plants can lead to changes in operating points, and it results in nonlinear variations of the plant variables and parameters. As there exist strong couplings between the main steam pressure control loop and the power output control loop in the boiler-turbine unit with large time-delay and uncertainties, automatic coordinated control of the two loops is a very challenging problem. This paper presents a new coordinated control strategy (CCS) which is organized into two levels: a basic control level and a high supervision level. PID-type controllers are used in the basic level to perform basic control functions while the decoupling between two control loops can be realized in the high level. Moreover, PID-type controllers can be auto-tuned to achieve a better control performance in the whole operating range and to reject the unmeasurable disturbances. A special subclass of fuzzy inference systems, namely the Gaussian partition system with evenly spaced midpoints, is also proposed to auto-tune the PID controller in the main steam pressure loop based on the error signal and its first difference to overcome uncertainties caused by changing fuel calorific value, machine wear, contamination of the boiler heating surfaces and plant modeling errors, etc. The developed CCS has been implemented in a power plant in China, and satisfactory industrial operation results demonstrate that the proposed control strategy has enhanced the adaptability and robustness of the process.

  16. A Generic Solution? Pharmaceuticals and the Politics of the Similar in Mexico

    E-Print Network [OSTI]

    Hayden, Corinne P.

    2007-01-01T23:59:59.000Z

    and outside the pharmaceutical industry often lament a long­by the transnational pharmaceutical industry (represented inthe transnational pharmaceutical industry-led by its

  17. Rebuttal: Should Academic Emergency Departments Collaborate In Pharmaceutical Industry-Sponsored Research?

    E-Print Network [OSTI]

    Hayden, Stephen R

    2003-01-01T23:59:59.000Z

    5. Angell M. The pharmaceutical industry - —to whom is itinvestigators and the pharmaceutical industry. NEJM. 7.their ties to the pharmaceutical industry. The question is

  18. Should Academic Emergency Departments Collaborate In Pharmaceutical Industry-Sponsored Research?

    E-Print Network [OSTI]

    Stone, Susan; Herbert, Mel

    2003-01-01T23:59:59.000Z

    investigators and the pharmaceutical industry. NEJM. 7.5. Angell M. The pharmaceutical industry - —to whom is itacademic centers. The pharmaceutical industry now runs much

  19. Pharmaceutical digital marketing and governance: illicit actors and challenges to global patient safety and public health

    E-Print Network [OSTI]

    Mackey, Tim K; Liang, Bryan A

    2013-01-01T23:59:59.000Z

    2012. 51. INTERPOL and pharmaceutical industry launch globalFederation of Pharmaceutical Industries and Associations,and generic pharmaceutical and wholesaler industries, the

  20. Advanced Coal Wind Hybrid: Economic Analysis

    E-Print Network [OSTI]

    Phadke, Amol

    2008-01-01T23:59:59.000Z

    farms with advanced coal generation facilities and operatingfarms with advanced coal generation facilities and operatingin the stand-alone coal generation option (IGCC+CCS plant)

  1. Advanced Coal Wind Hybrid: Economic Analysis

    E-Print Network [OSTI]

    Phadke, Amol

    2008-01-01T23:59:59.000Z

    advanced coal-wind hybrid combined cycle power plant naturalwhen the wind generation drops, the power plant needs toa CSP plant, a wind plant produces power during all hours of

  2. Advanced Pipe Replacement Procedure for a Defective CRDM Housing Nozzle Enables Continued Normal Operation of a Nuclear Power Plant

    SciTech Connect (OSTI)

    Gilmore, Geoff; Becker, Andrew [Climax Portable Machine Tools, Inc., 2712 East Second Street, Newberg, OR 97132 (United States)

    2006-07-01T23:59:59.000Z

    During the 2003 outage at the Ringhals Nuclear Plant in Sweden, a leak was found in the vicinity of a Control Rod Drive Mechanism (CRDM) housing nozzle at Unit 1. Based on the ALARA principle for radioactive contamination, a unique repair process was developed. The repair system includes utilization of custom, remotely controlled GTAW-robots, a CNC cutting and finishing machine, snake-arm robots and NDE equipment. The success of the repair solution was based on performing the machining and welding operations from the inside of the SCRAM pipe through the CRDM housing since accessibility from the outside was extremely limited. Before the actual pipe replacement procedure was performed, comprehensive training programs were conducted. Training was followed by certification of equipment, staff and procedures during qualification tests in a full scale mock-up of the housing nozzle. Due to the ingenuity of the overall repair solution and training programs, the actual pipe replacement procedure was completed in less than half the anticipated time. As a result of the successful pipe replacement, the nuclear power plant was returned to normal operation. (authors)

  3. E-Print Network 3.0 - air conditioning plants Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    plants Search Powered by Explorit Topic List Advanced Search Sample search results for: air conditioning plants...

  4. E-Print Network 3.0 - air conditioning plant Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    plant Search Powered by Explorit Topic List Advanced Search Sample search results for: air conditioning plant...

  5. The Chemical and Pharmaceutical Industry Susan Brench (1984)

    E-Print Network [OSTI]

    Goldschmidt, Christina

    The Chemical and Pharmaceutical Industry Susan Brench (1984) If you have any questions, or would:alumnae@murrayedwards.cam.ac.uk The products and services of the chemical and pharmaceutical industry deliver clean water, vital medicines? · Chemical and pharmaceutical businesses in the UK are a £60 billion industry. · Every day for the past

  6. Market Size and Pharmaceutical Innovation Pierre Dubois, Olivier de Mouzony

    E-Print Network [OSTI]

    Sekhon, Jasjeet S.

    market size and innovation in the pharmaceutical industry using improved, and newer, methods and data. We and innovation in the pharmaceutical industry. More precisely we shall estimate the elasticity of innovation (asMarket Size and Pharmaceutical Innovation Pierre Dubois, Olivier de Mouzony , Fiona Scott

  7. Modelling the mechanical behaviour of pharmaceutical powders during compaction

    E-Print Network [OSTI]

    Elliott, James

    are made of dry powder through a powder compaction process. In the pharmaceutical industry, billionsModelling the mechanical behaviour of pharmaceutical powders during compaction C.-Y. Wua,T, O.M. Ruddyb , A.C. Benthamb , B.C. Hancockc , S.M. Besta , J.A. Elliotta a Pfizer Institute for Pharmaceutical

  8. RISK MANAGEMENT IN REAL OPTIONS BASED PHARMACEUTICAL PORTFOLIO PLANNING

    E-Print Network [OSTI]

    Maranas, Costas

    : 814-863-9958. Fax: 814-865-7846. In the pharmaceutical industry, the optimal management of the newRISK MANAGEMENT IN REAL OPTIONS BASED PHARMACEUTICAL PORTFOLIO PLANNING Michael J. Rogers, Anshuman incorporate a Monte Carlo simulation procedure to a stochastic optimization model (OptFolio) of pharmaceutical

  9. COORDINATING ON LOWER PRICES: PHARMACEUTICAL PRICING

    E-Print Network [OSTI]

    Sadoulet, Elisabeth

    of political activity on pharmaceutical prices, focusing on the health care reform period. We characterize health care reform discussions in 1993, large-scale efforts to curb drug prices were debated and seemed everywhere from the Catastrophic Health Insurance Bill to proposals for Medicare coverage of drugs. During

  10. Applications of Nanotechnology to Pharmaceutical Product Development

    E-Print Network [OSTI]

    Fisher, Frank

    Applications of Nanotechnology to Pharmaceutical Product Development Wednesday January 27, 2010 physical forms can create limitations in terms of product performance and/or safety. Nanotechnology can of the clinical benefits of using nanotechnology in drug product development.. Bill Bosch has been involved

  11. Pharmaceuticals, Hormones, and Other Organic Wastewater

    E-Print Network [OSTI]

    and ecological health effects resulting from the production, use, and disposal of numerous chemicals that offer discharges to water and air resources. Household chemicals, pharmaceuticals, and other consumables as well (i.e. downstream of intense urbanization and livestock production). OWCs were prevalent during

  12. Improving Energy Efficiency in Pharmaceutical ManufacturingOperations -- Part I: Motors, Drives and Compressed Air Systems

    SciTech Connect (OSTI)

    Galitsky, Christina; Chang, Sheng-chien; Worrell, Ernst; Masanet,Eric

    2006-04-01T23:59:59.000Z

    In Part I of this two-part series, we focus on efficient use of motors, drives and pumps, both for process equipment and compressed air systems. Pharmaceutical manufacturing plants in the U.S. spend nearly $1 billion each year for the fuel and electricity they need to keep their facilities running (Figure 1, below). That total that can increase dramatically when fuel supplies tighten and oil prices rise, as they did last year. Improving energy efficiency should be a strategic goal for any plant manager or manufacturing professional working in the drug industry today. Not only can energy efficiency reduce overall manufacturing costs, it usually reduces environmental emissions, establishing a strong foundation for a corporate greenhouse-gas-management program. For most pharmaceutical manufacturing plants, Heating, Ventilation and Air Conditioning (HVAC) is typically the largest consumer of energy, as shown in Table 1 below. This two-part series will examine energy use within pharmaceutical facilities, summarize best practices and examine potential savings and return on investment. In this first article, we will focus on efficient use of motors, drives and pumps, both for process equipment and compressed air systems. Part 2, to be published in May, will focus on overall HVAC systems, building management and boilers.

  13. Agua Caliente, World's Largest Solar Photovoltaic Plant, Helps...

    Office of Environmental Management (EM)

    Agua Caliente, World's Largest Solar Photovoltaic Plant, Helps Advance America's Solar Leadership Agua Caliente, World's Largest Solar Photovoltaic Plant, Helps Advance America's...

  14. aicd advanced: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  15. advanced quantra fticr: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  16. advanced nuclear reactor: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  17. abwr advanced boiling: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  18. advanced nuclear power: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  19. advanced computational model: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  20. advanced metal-membrane technology-commercialization: Topics...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  1. advanced boiling curve: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  2. advanced thermal reactor: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  3. advanced dynamic models: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  4. advanced power group: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  5. advanced applications singapore: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  6. advanced burner reactors: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  7. advanced application examples: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  8. applying advanced model: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  9. advanced accelerator applications: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  10. advanced cervix carcinoma: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  11. advanced power systems: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  12. advanced burner reactor: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  13. advanced modeling tool: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  14. advanced oropharyngeal carcinoma: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  15. advanced unresectable rectal: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  16. advanced vulvar carcinomas: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  17. advanced maxillary sinus: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  18. advanced epidermoid carcinoma: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  19. advanced nsclc patients: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  20. advanced hypopharyngeal carcinoma: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  1. advanced intrahepatic cholangiocarcinoma: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  2. advanced large power: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  3. advanced radioisotope power: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  4. advanced melanoma results: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  5. advanced hippotherapy simulator: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  6. advanced model approaches: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  7. advanced nuclear reactors: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  8. advanced applications kyoto: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  9. advanced orthotopic hepatocellular: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  10. advanced nasopharyngeal carcinoma: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  11. advanced thermal reactor fugen: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  12. advanced coolside sorbent: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  13. advanced power system: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  14. advanced computational modeling: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  15. advanced fimbrial ectopic: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  16. advanced mixing models: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  17. aries advanced power: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  18. The Blanche and Irwin Lerner Center for the Study of Pharmaceutical

    E-Print Network [OSTI]

    Lin, Xiaodong

    involved with the pharmaceutical and biotechnology industries better understand the structure, competitive pharmaceutical industry, containing specialized analyses of drug pricing and reimbursement, sales and marketing with extensive experience in the pharmaceutical and biotechnology industries, as well as Rutgers Business School

  19. SSPPS STRATEGIC PLAN Pharmacy Education, Pharmaceutical Sciences Research, Clinical Pharmacy Practice

    E-Print Network [OSTI]

    Gleeson, Joseph G.

    and medical centers, community pharmacy settings, academia, government and the pharmaceutical industry 3SSPPS STRATEGIC PLAN Pharmacy Education, Pharmaceutical Sciences Research, Clinical Pharmacy of Pharmacy and Pharmaceutical Sciences (SSPPS). The plan emanates from the work of three committees and has

  20. Monitoring Industrial Pharmaceutical Crystallization Processes Using Acoustic Emission in Pure and Impure Media.

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Monitoring Industrial Pharmaceutical Crystallization Processes Using Acoustic Emission in Pure processes was almost never evaluated in the field of industrial pharmaceutical crystallization. Few papers. Introduction The pharmaceutical industry is set against strong requests on behalf of both consumers

  1. Looking For Traces of Pharmaceuticals in Drinking Water

    E-Print Network [OSTI]

    Nebraska-Lincoln, University of

    Looking For Traces of Pharmaceuticals in Drinking Water By Daniel D. Snow, Ph.D. Director traces of drugs in the public drinking water supplies of 24 major U.S. metropolitan areas. This has in drinking water supplies is not new, but the classes of contaminants being tested for are. Pharmaceuticals

  2. Technology Reports Solution Concentration Prediction for Pharmaceutical Crystallization Processes

    E-Print Network [OSTI]

    Braatz, Richard D.

    Using Robust Chemometrics and ATR FTIR Spectroscopy Timokleia Togkalidou, Hsien-Hsin Tung,*, Yongkui Sun systems in the presence of impurities and over a wide range of temperature. To our best knowledge in pharmaceutical industry such as crystal size distribution (CSD) and crystal shape of the product pharmaceuticals

  3. Lean supply chain in pharmaceutical industry : modeling and simulation of a SAP environment

    E-Print Network [OSTI]

    Hou, Billy

    2011-01-01T23:59:59.000Z

    The global pharmaceutical business environment has been rapidly changing and has more competitive. Competition in pharmaceutical industry extended far beyond the traditional battle field, research and development. Bayer ...

  4. E-Print Network 3.0 - american pharmaceutical association Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    all... Jersey in 2000, Marc worked for a small pharmaceutical research firm and then for Dow Jones. After taking... in pharmaceutical management. "The school has great...

  5. Toward Direct Biosynthesis of Drop-in Ready Biofuels in Plants: Rapid Screening and Functional Genomic Characterization of Plant-derived Advanced Biofuels and Implications for Coproduction in Lignocellulosic Feedstocks.

    E-Print Network [OSTI]

    Joyce, Blake Lee

    2013-01-01T23:59:59.000Z

    ??Advanced biofuels that are “drop-in” ready, completely fungible with petroleum fuels, and require minimal infrastructure to process a finished fuel could provide transportation fuels in… (more)

  6. Thorium, uranium and rare earth elements content in lanthanide concentrate (LC) and water leach purification (WLP) residue of Lynas advanced materials plant (LAMP)

    SciTech Connect (OSTI)

    AL-Areqi, Wadeeah M., E-mail: walareqi@yahoo.com; Majid, Amran Ab., E-mail: walareqi@yahoo.com; Sarmani, Sukiman, E-mail: walareqi@yahoo.com [Nuclear Science Programme, School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi (Malaysia)

    2014-02-12T23:59:59.000Z

    Lynas Advanced Materials Plant (LAMP) has been licensed to produce the rare earths elements since early 2013 in Malaysia. LAMP processes lanthanide concentrate (LC) to extract rare earth elements and subsequently produce large volumes of water leach purification (WLP) residue containing naturally occurring radioactive material (NORM). This residue has been rising up the environmental issue because it was suspected to accumulate thorium with significant activity concentration and has been classified as radioactive residue. The aim of this study is to determine Th-232, U-238 and rare earth elements in lanthanide concentrate (LC) and water leach purification (WLP) residue collected from LAMP and to evaluate the potential radiological impacts of the WLP residue on the environment. Instrumental Neutron Activation Analysis and ?-spectrometry were used for determination of Th, U and rare earth elements concentrations. The results of this study found that the concentration of Th in LC was 1289.7 ± 129 ppm (5274.9 ± 527.6Bq/kg) whereas the Th and U concentrations in WLP were determined to be 1952.9±17.6 ppm (7987.4 ± 71.9 Bq/kg) and 17.2 ± 2.4 ppm respectively. The concentrations of Th and U in LC and WLP samples determined by ?- spectrometry were 1156 ppm (4728 ± 22 Bq/kg) and 18.8 ppm and 1763.2 ppm (7211.4 Bq/kg) and 29.97 ppm respectively. This study showed that thorium concentrations were higher in WLP compare to LC. This study also indicate that WLP residue has high radioactivity of {sup 232}Th compared to Malaysian soil natural background (63 - 110 Bq/kg) and come under preview of Act 304 and regulations. In LC, the Ce and Nd concentrations determined by INAA were 13.2 ± 0.6% and 4.7 ± 0.1% respectively whereas the concentrations of La, Ce, Nd and Sm in WLP were 0.36 ± 0.04%, 1.6%, 0.22% and 0.06% respectively. This result showed that some amount of rare earth had not been extracted and remained in the WLP and may be considered to be reextracted.

  7. A Synergistic Combination of Advanced Separation and Chemical Scale Inhibitor Technologies for Efficient Use of Imparied Water As Cooling Water in Coal-based Power Plants

    SciTech Connect (OSTI)

    Jasbir Gill

    2010-08-30T23:59:59.000Z

    Nalco Company is partnering with Argonne National Laboratory (ANL) in this project to jointly develop advanced scale control technologies that will provide cost-effective solutions for coal-based power plants to operate recirculating cooling water systems at high cycles using impaired waters. The overall approach is to use combinations of novel membrane separations and scale inhibitor technologies that will work synergistically, with membrane separations reducing the scaling potential of the cooling water and scale inhibitors extending the safe operating range of the cooling water system. The project started on March 31, 2006 and ended in August 30, 2010. The project was a multiyear, multi-phase project with laboratory research and development as well as a small pilot-scale field demonstration. In Phase 1 (Technical Targets and Proof of Concept), the objectives were to establish quantitative technical targets and develop calcite and silica scale inhibitor chemistries for high stress conditions. Additional Phase I work included bench-scale testing to determine the feasibility of two membrane separation technologies (electrodialysis ED and electrode-ionization EDI) for scale minimization. In Phase 2 (Technology Development and Integration), the objectives were to develop additional novel scale inhibitor chemistries, develop selected separation processes, and optimize the integration of the technology components at the laboratory scale. Phase 3 (Technology Validation) validated the integrated system's performance with a pilot-scale demonstration. During Phase 1, Initial evaluations of impaired water characteristics focused on produced waters and reclaimed municipal wastewater effluents. Literature and new data were collected and evaluated. Characteristics of produced waters vary significantly from one site to another, whereas reclaimed municipal wastewater effluents have relatively more uniform characteristics. Assessment to date confirmed that calcite and silica/silicate are two common potential cycle-limiting minerals for using impaired waters. For produced waters, barium sulfate and calcium sulfate are two additional potential cycle-limiting minerals. For reclaimed municipal wastewater effluents, calcium phosphate scaling can be an issue, especially in the co-presence of high silica. Computational assessment, using a vast amount of Nalco's field data from coal fired power plants, showed that the limited use and reuse of impaired waters is due to the formation of deposit caused by the presence of iron, high hardness, high silica and high alkalinity in the water. Appropriate and cost-effective inhibitors were identified and developed - LL99B0 for calcite and gypsum inhibition and TX-15060 for silica inhibition. Nalco's existing dispersants HSP-1 and HSP-2 has excellent efficacy for dispersing Fe and Mn. ED and EDI were bench-scale tested by the CRADA partner Argonne National Laboratory for hardness, alkalinity and silica removal from synthetic make-up water and then cycled cooling water. Both systems showed low power consumption and 98-99% salt removal, however, the EDI system required 25-30% less power for silica removal. For Phase 2, the EDI system's performance was optimized and the length of time between clean-in-place (CIP) increased by varying the wafer composition and membrane configuration. The enhanced EDI system could remove 88% of the hardness and 99% of the alkalinity with a processing flux of 19.2 gal/hr/m{sup 2} and a power consumption of 0.54 kWh/100 gal water. Bench tests to screen alternative silica/silicate scale inhibitor chemistries have begun. The silica/silicate control approaches using chemical inhibitors include inhibition of silicic acid polymerization and dispersion of silica/silicate crystals. Tests were conducted with an initial silica concentration of 290-300 mg/L as SiO{sub 2} at pH 7 and room temperature. A proprietary new chemistry was found to be promising, compared with a current commercial product commonly used for silica/silicate control. Additional pilot cooling tower testing confirmed

  8. List of Resident Sites for UC San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences Students

    E-Print Network [OSTI]

    Gleeson, Joseph G.

    Roche/Rutgers Kaiser Orange County/Irvine Oncology Fellowship - UCSD/Pfizer Pharmaceutical Industry Fellowship - Rutgers/F. Hoffman-LaRoche Pharmaceutical Industry Fellowship - Rutgers/Novartis Pharmaceutical Industry Fellowship - Rutgers/Schering-Plough Corporation Pharmaceutical Industry Fellowship - St. John

  9. Pharmaceutical Chemistry B.S. 1. General description and characteristics of the program.

    E-Print Network [OSTI]

    .D. degrees in chemistry work in the pharmaceutical industry. Pharmaceutical companies need employees to work productively in the pharmaceutical industry, especially in the areas of research and developmentPharmaceutical Chemistry B.S. 1. General description and characteristics of the program

  10. CERNA WORKING PAPER SERIES Pharmaceutical Regulation and Intellectual Property: the Third Side of the Triangle

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    &D-intensive industries, such as pharmaceuticals. The Pharmaceutical Sector Inquiry published by the European Commission3 of the pharmaceutical industry. It thus attempts to close the third side of the triangle formed by the vertices1 CERNA WORKING PAPER SERIES Pharmaceutical Regulation and Intellectual Property: the Third Side

  11. Advanced Process Management and Implementation

    E-Print Network [OSTI]

    Robinson, J.

    Advanced Process Management is a method to achieve optimum process performance during the life cycle of a plant through proper design, effective automation, and adequate operator decision support. Developing a quality process model is an effective...

  12. Computer-aided rational solvent selection for pharmaceutical crystallization

    E-Print Network [OSTI]

    Chen, Jie, Ph. D. Massachusetts Institute of Technology

    2010-01-01T23:59:59.000Z

    Solvents play an important role in crystallization, a commonly used separation and purification technique in the pharmaceutical, chemical and food industries. They affect crystal properties such as particle size distribution, ...

  13. Crystallization process development and spherical agglomerates for pharmaceutical processing applications

    E-Print Network [OSTI]

    Quon, Justin (Justin Louie)

    2013-01-01T23:59:59.000Z

    The control of crystallization steps is essential in the production of many materials in the pharmaceutical, materials, and chemical industries. Additionally, due to increasing costs of research and development, reductions ...

  14. Three essays on the development and diffusion of pharmaceutical innovations

    E-Print Network [OSTI]

    Azoulay, Pierre

    2001-01-01T23:59:59.000Z

    The thesis comprises three essays on various aspects of the development and diffusion of pharmaceutical innovations, woven together by the idea that the production of clinical knowl- edge influences organizational design, ...

  15. Achieving business and operational excellence in the pharmaceutical industry

    E-Print Network [OSTI]

    Coffey, Shonna (Shonna Marie)

    2008-01-01T23:59:59.000Z

    Historically the pharmaceutical industry has been highly profitable. However, the increasing regulatory requirements, bargaining power of buyers, and drug failures together with the threat of biosimilars and decreasing R&D ...

  16. Analysis of global channel costs for the pharmaceutical industry

    E-Print Network [OSTI]

    Rimling, Eric C. (Eric Christopher)

    2009-01-01T23:59:59.000Z

    The pharmaceutical industry creates products which often have more than one supply chain channel, defined as a route through the supply chain network from sourcing to the end market. Each channel's specific cost characteristics ...

  17. Business models for information commons in the pharmaceutical industry

    E-Print Network [OSTI]

    Bharadwaj, Ragu

    2009-01-01T23:59:59.000Z

    The pharmaceutical industry needs new modes of innovation. The industry's innovation system - based on massive investments in R&D protected by intellectual property rights - has worked well for many years, providing ...

  18. Hydroxyalkyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals

    DOE Patents [OSTI]

    Katti, K.V.; Singh, P.R.; Reddy, V.S.; Katti, K.K.; Volkert, W.A.; Ketring, A.R.

    1999-03-02T23:59:59.000Z

    This research discloses a compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises a functionalized hydroxyalkyl phosphine ligand and a metal combined with the ligand. 16 figs.

  19. Improving energy efficiency in a pharmaceutical manufacturing environment -- office building

    E-Print Network [OSTI]

    Li, Wu, M. Eng Massachusetts Institute of Technology

    2009-01-01T23:59:59.000Z

    Reducing energy consumption without compromising the quality of products in a pharmaceutical manufacturing environment and maintaining the comfort of employees is of critical important in maintaining the financial viability ...

  20. Exploration of parameters for the continuous blending of pharmaceutical powders

    E-Print Network [OSTI]

    Lin, Ben Chien Pang

    2011-01-01T23:59:59.000Z

    The transition from traditional batch blending to continuous blending is an opportunity for the pharmaceutical industry to reduce costs and improve quality control. This operational shift necessitates a deeper understanding ...

  1. Inventory management in a pharmaceutical company : minimizing discard practices

    E-Print Network [OSTI]

    Wang, Xiaojun, M. Eng. Massachusetts Institute of Technology

    2010-01-01T23:59:59.000Z

    Pharmaceutical company SPM has over 400 cases of inventory discards over the past five years which constitute a significant operating cost. Due to the complexity and randomness of each case, the root causes that result in ...

  2. Hydroxyalkyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals

    DOE Patents [OSTI]

    Katti, Kattesh V. (Columbia, MO); Singh, Prahlad R. (Columbia, MO); Reddy, V. Sreenivasa (Columbia, MO); Katti, Kavita K. (Columbia, MO); Volkert, Wynn A. (Columbia, MO); Ketring, Alan R. (Columbia, MO)

    1999-01-01T23:59:59.000Z

    A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises a functionalized hydroxyalkyl phosphine ligand and a metal combined with the ligand.

  3. Advanced LBB methodology and considerations

    SciTech Connect (OSTI)

    Olson, R.; Rahman, S.; Scott, P. [Battelle, Columbus, OH (United States)] [and others

    1997-04-01T23:59:59.000Z

    LBB applications have existed in many industries and more recently have been applied in the nuclear industry under limited circumstances. Research over the past 10 years has evolved the technology so that more advanced consideration of LBB can now be given. Some of the advanced considerations for nuclear plants subjected to seismic loading evaluations are summarized in this paper.

  4. What future physicians want : a comparative analysis of the perception of medical students and pharmaceutical industry executives regarding the future of pharmaceutical sales

    E-Print Network [OSTI]

    Khan, Rehan A. (Rehan Abbas)

    2007-01-01T23:59:59.000Z

    The leading publicly traded pharmaceutical companies ("Big Pharma) in the US are facing a commercial crisis - their sales structure collectively consisting of more than 100,000 pharmaceutical sales representatives, originally ...

  5. Advances in drug therapy for systemic lupus erythematosus

    E-Print Network [OSTI]

    Wallace, Daniel J

    2010-01-01T23:59:59.000Z

    2470-2480. 26. Teva Pharmaceutical Industries Ltd. : Pressbeing that patient, the pharmaceutical industry invested its

  6. Study of Pu consumption in light water reactors: Evaluation of GE advanced boiling water reactor plants, compilation of Phase 1C task reports

    SciTech Connect (OSTI)

    Not Available

    1994-01-15T23:59:59.000Z

    This report summarizes the evaluations conducted during Phase 1C of the Pu Disposition Study have provided further results which reinforce the conclusions reached during Phase 1A & 1B: These conclusions clearly establish the benefits of the fission option and the use of the ABWR as a reliable, proven, well-defined and cost-effective means available to disposition the weapons Pu. This project could be implemented in the near-term at a cost and on a schedule being validated by reactor plants currently under construction in Japan and by cost and schedule history and validated plans for MOX plants in Europe. Evaluations conducted during this phase have established that (1) the MOX fuel is licensable based on existing criteria for new fuel with limited lead fuel rod testing, (2) that the applicable requirements for transport, handling and repository storage can be met, and (3) that all the applicable safeguards criteria can be met.

  7. advanced gas-cooled reactor: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  8. advanced coal-based power: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  9. advanced test-analysis model: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  10. advanced self-shielding models: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  11. advanced t-stage nasopharyngeal: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  12. advanced beam-dynamics simulation: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  13. advanced unresectable non-small: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  14. advanced gas-cooled reactors: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    . . . . 18 3.4.1 Heat Exchanger - Code description . . . . . . . . . . . . . . . 18 3.4.2 Simulation ResultsADVANCED POWER PLANT MODELING WITH APPLICATIONS TO THE ADVANCED BOILING...

  15. Development of an Optimum Tracer Set for Apportioning Emissions of Individual Power Plants Using Highly Time-Resolved Measurements and Advanced Receptor Modeling

    SciTech Connect (OSTI)

    John Ondov; Gregory Beachley

    2007-07-05T23:59:59.000Z

    In previous studies, 11 elements (Al, As, Cd, Cr, Cu, Fe, Mn, Ni, Pb, Se, and Zn) were determined in 30-minute aerosol samples collected with the University of Maryland Semicontinuous Elements in Aerosol Sampler (SEAS; Kidwell and Ondov, 2001, 2004; SEAS-II) in several locations in which air quality is influenced by emissions from coal- or oil-fired power plants. At this time resolution, plumes from stationary high temperature combustion sources are readily detected as large excursions in ambient concentrations of elements emitted by these sources (Pancras et al. ). Moreover, the time-series data contain intrinsic information on the lateral diffusion of the plume (e.g., {sigma}{sub y}), which Park et al. (2005 and 2006) have exploited in their Pseudo-Deterministic Receptor Model (PDRM), to calculate emission rates of SO{sub 2} and 11 elements (mentioned above) from four individual coal- and oil-fired power plants in the Tampa Bay area. In the current project, we proposed that the resolving power of source apportionment methods might be improved by expanding the set of maker species and that there exist some optimum set of marker species that could be used. The ultimate goal was to determine the utility of using additional elements to better identify and isolate contributions of individual power plants to ambient levels of PM and its constituents. And, having achieved better resolution, achieve, also, better emission rate estimates. In this study, we optimized sample preparation and instrumental protocols for simultaneous analysis of 28 elements in dilute slurry samples collected with the SEAS with a new state-of-the-art Thermo-Systems, Inc., X-series II, Inductively Coupled Plasma Mass Spectroscopy (ICP-MS), and reanalyzed the samples previously collected in Tampa during the modeling period studied by Park et al. (2005) in which emission rates from four coal- and oil-fired power plants affected air quality at the sampling site. In the original model, Park et al. (2005), included 6 sources. Herein, we reassessed the number of contributing sources in light of the new data. A comprehensive list of sources was prepared and both our Gaussian Plume model and PMF were used to identify and predict the relative strengths of source contributions at the receptor sites. Additionally, PDRM was modified to apply National Inventory Emissions, Toxic Release Inventory, and Chemical Mass Balance source profile data to further constrain solutions. Both the original Tampa data set (SO{sub 2} plus 11 elements) and the new expanded data set (SO{sub 2} plus 23 elements) were used to resolve the contributions of particle constituents and PM to sources using Positive Matrix Factorization (PMF) and PDRM.

  16. Theoretical and experimental investigation of particle interactions in pharmaceutical powder blending

    E-Print Network [OSTI]

    Pu, Yu, Ph. D. Massachusetts Institute of Technology

    2007-01-01T23:59:59.000Z

    In pharmaceutical manufacturing practices, blending of active pharmaceutical ingredient (API) with excipients is a crucial step in that homogeneity of active ingredient after blending is a key issue for the quality assurance ...

  17. Design of a small-scale continuous linear motion pharmaceutical filtration module

    E-Print Network [OSTI]

    Wong, Katherine Wing-Shan

    2010-01-01T23:59:59.000Z

    A new small-scale continuous linear motion pharmaceutical filtration prototype was designed, fabricated, and tested. The goal of this unit is to filter an Active Pharmaceutical Ingredient (API) from a mixture of API ...

  18. Solid-State Physical Form Detection and Quantitation of Pharmaceuticals in Formulations

    E-Print Network [OSTI]

    Gorman, Eric

    2011-03-25T23:59:59.000Z

    The majority of pharmaceutical dosage forms are marketed as solids, and the active pharmaceutical ingredient (API) can exist in various physical forms. These physical forms can be either crystalline or amorphous, and will ...

  19. The pharmaceutical supply chain : a diagnosis of the state-of-the-art

    E-Print Network [OSTI]

    Singh, Mahender Pal, 1965-

    2005-01-01T23:59:59.000Z

    This study explores the current supply chain trends in the pharmaceutical industry. The main objective of the study is to characterize the pharmaceutical industry and identify excellent supply chain practices. Indeed, the ...

  20. Simulation modeling to predict drug pipeline throughput in early pharmaceutical R&D

    E-Print Network [OSTI]

    Heyman, Jeffrey B. (Jeffrey Brian)

    2010-01-01T23:59:59.000Z

    With high costs and growing concern about research and development (R&D) productivity, the pharmaceutical industry is under pressure to efficiently allocate R&D funds. Nonetheless, pharmaceutical R&D involves considerable ...

  1. Source Characterization and Pretreatment Evaluation of Pharmaceuticals and Personal Care Products in Healthcare Facility Wastewater

    E-Print Network [OSTI]

    Nagarnaik, Pranav Mukund

    2012-07-16T23:59:59.000Z

    Healthcare facility wastewaters are a potentially important and under characterized source of pharmaceuticals and personal care products to the environment. In this study the composition and magnitude of pharmaceuticals and personal care products...

  2. Data Warehouse Design for Pharmaceutical Drug Discovery Research Melinda G. Axel and Il-Yeol Song

    E-Print Network [OSTI]

    Song, Il-Yeol

    an analysis of the principal activities involved in drug discovery in the pharmaceutical industry, and a setData Warehouse Design for Pharmaceutical Drug Discovery Research Melinda G. Axel and Il-Yeol Song: axel@superlink.net, songiy@post.drexel.edu Abstract Pharmaceutical companies spend billions of dollars

  3. Clay and non-clay minerals in the pharmaceutical industry Part I. Excipients and medical applications

    E-Print Network [OSTI]

    Ahmad, Sajjad

    Clay and non-clay minerals in the pharmaceutical industry Part I. Excipients and medical in the pharmaceutical industry as lubricants, desiccants, disintegrants, diluents, binders, pigments and opaci ers form 17 July 2009 Accepted 22 July 2009 Available online 29 July 2009 Keywords: Minerals Pharmaceutical

  4. Review Article Clay and non-clay minerals in the pharmaceutical and cosmetic industries

    E-Print Network [OSTI]

    Ahmad, Sajjad

    Review Article Clay and non-clay minerals in the pharmaceutical and cosmetic industries Part II Pharmaceutical industry Cosmetic industry Active ingredients Physical and physico-chemical properties A wide range and variety of minerals are used in the pharmaceutical industry as active ingredients

  5. A modified Drucker-Prager Cap model for die compaction simulation of pharmaceutical powders

    E-Print Network [OSTI]

    Elliott, James

    ;1. Introduction As the most widely used dosage form for drug delivery in the pharmaceutical industry, tablets haveA modified Drucker-Prager Cap model for die compaction simulation of pharmaceutical powders L Institute for Pharmaceutical Materials Science, Department of Materials Science and Metallurgy, University

  6. CONSULTATION RESPONSE Wellcome Trust response to Physicians and the Pharmaceutical Industry Working

    E-Print Network [OSTI]

    Rambaut, Andrew

    CONSULTATION RESPONSE Wellcome Trust response to Physicians and the Pharmaceutical Industry Working Party April 2008 Page 1 of 4 Royal College of Physicians: Physicians and the Pharmaceutical Industry to respond to the Royal College of Physicians consultation on physicians and the pharmaceutical industry

  7. Pharm.D. / Ph.D. Program UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences

    E-Print Network [OSTI]

    Gleeson, Joseph G.

    students for positions in academia, government and the pharmaceutical industry that will require experience in the pharmaceutical industry. The program is a joint program between the SSPPS and selected graduate programsPharm.D. / Ph.D. Program UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences Information

  8. Determination of enantiomeric compositions of pharmaceutical products by near-infrared spectrometry

    E-Print Network [OSTI]

    Reid, Scott A.

    surprising that the pharmaceutical industry needs effective methods to determine the enantiomeric purityDetermination of enantiomeric compositions of pharmaceutical products by near-infrared spectrometry of chiral effects, the FAA in 1992 issued a mandate requiring pharmaceutical companies to evaluate

  9. What's in your water? An Overview of the Dangers of Pharmaceutical Waste

    E-Print Network [OSTI]

    Wang, Xiaorui "Ray"

    What's in your water? An Overview of the Dangers of Pharmaceutical Waste An environmental education regarding the dangers of pharmaceutical waste and the impact of improper disposal practices on our practicing safe disposal of pharmaceutical waste to prevent further damage to our water system, our food

  10. The Drivers of Mergers and Acquisitions in Pharmaceutical Industry

    E-Print Network [OSTI]

    Ji, Fan

    2012-07-16T23:59:59.000Z

    We examine the determinants and drivers of 112 mergers and acquisitions (M&A) activities exceed 50 million values in the pharmaceutical industry using COMPUSTAT, SDC and FDA data during the period 1980-2010 with random effect logit model. We find...

  11. Multifunctional ligand for use as a diagnostic or therapeutic pharmaceutical

    DOE Patents [OSTI]

    Katti, K.V.; Volkert, W.A.; Ketring, A.R.; Singh, P.R.

    1996-05-14T23:59:59.000Z

    A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical are revealed. The ligand comprises either a phosphorous or germanium core and at least two hydrazine groups forming a ligand for bonding to a metal extending from the phosphorous or germanium core.

  12. Multifunctional ligand for use as a diagnostic or therapeutic pharmaceutical

    DOE Patents [OSTI]

    Katti, Kattesh V. (Columbia, MO); Volkert, Wynn A. (Columbia, MO); Ketring, Alan R. (Columbia, MO); Singh, Prahlad R. (Columbia, MO)

    1996-01-01T23:59:59.000Z

    A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises either a phosphorous or germanium core and at least two hydrazine groups forming a ligand for bonding to a metal extending from the phosphorous or germanium core.

  13. Next Generation Safeguards Initiative: Analysis of Probability of Detection of Plausible Diversion Scenarios at Gas Centrifuge Enrichment Plants Using Advanced Safeguards

    SciTech Connect (OSTI)

    Hase, Kevin R. [Los Alamos National Laboratory; Hawkins Erpenbeck, Heather [Los Alamos National Laboratory; Boyer, Brian D. [Los Alamos National Laboratory

    2012-07-10T23:59:59.000Z

    Over the last decade, efforts by the safeguards community, including inspectorates, governments, operators and owners of centrifuge facilities, have given rise to new possibilities for safeguards approaches in enrichment plants. Many of these efforts have involved development of new instrumentation to measure uranium mass and uranium-235 enrichment and inspection schemes using unannounced and random site inspections. We have chosen select diversion scenarios and put together a reasonable system of safeguards equipment and safeguards approaches and analyzed the effectiveness and efficiency of the proposed safeguards approach by predicting the probability of detection of diversion in the chosen safeguards approaches. We analyzed the effect of redundancy in instrumentation, cross verification of operator instrumentation by inspector instrumentation, and the effects of failures or anomalous readings on verification data. Armed with these esults we were able to quantify the technical cost benefit of the addition of certain instrument suites and show the promise of these new systems.

  14. advanced simulation technologies: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of high-performance tokamak plasmas together with advanced technology in a fusion power plant. Several to ARIES-RS that led to plasmas with higher N and . Advanced...

  15. advanced simulation technology: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of high-performance tokamak plasmas together with advanced technology in a fusion power plant. Several to ARIES-RS that led to plasmas with higher N and . Advanced...

  16. Power Plant Power Plant

    E-Print Network [OSTI]

    Tingley, Joseph V.

    Basin Center for Geothermal Energy at University of Nevada, Reno (UNR) 2 Nevada Geodetic LaboratoryStillwater Power Plant Wabuska Power Plant Casa Diablo Power Plant Glass Mountain Geothermal Area Lassen Geothermal Area Coso Hot Springs Power Plants Lake City Geothermal Area Thermo Geothermal Area

  17. E-Print Network 3.0 - applying advanced molecular Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    molecular Search Powered by Explorit Topic List Advanced Search Sample search results for: applying advanced molecular Page: << < 1 2 3 4 5 > >> 1 16:765:510 Advanced Plant...

  18. Partnership between pharmaceutical industry and RBS ensures relevant curriculum producing top-talent graduates pharma companies need

    E-Print Network [OSTI]

    Lin, Xiaodong

    Partnership between pharmaceutical industry and RBS ensures relevant curriculum producing top and pharmaceutical industry. The Rutgers Pharmaceutical Management MBA has provided the industry a pipeline of the program is that many executives from the pharmaceutical industry teach RBS students themselves, offering

  19. argonne advanced research reactor: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and aerospace industry. ... enables methods, is used for in-service inspection of nuclear power plant components, such as tubing, piping the safe operationof advanced nuclear...

  20. activity advanced science: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in Plant Fields Modern Physical Chemistry). It is designed for undergraduates majoring in science and engineering. We will offer cutting edge classes in advanced sciences and...

  1. advancing pet science: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in Plant Fields Modern Physical Chemistry). It is designed for undergraduates majoring in science and engineering. We will offer cutting edge classes in advanced sciences and...

  2. advances compuational science: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in Plant Fields Modern Physical Chemistry). It is designed for undergraduates majoring in science and engineering. We will offer cutting edge classes in advanced sciences and...

  3. GMP Compliance for Pharmaceutical Excipients in the Glycerin Industry

    E-Print Network [OSTI]

    Elliot, Christina

    2008-12-19T23:59:59.000Z

    will be shared with Company XYZ. - iv - Acronyms API – Active Pharmaceutical Ingredient cGMP’s – Current Good Manufacturing Practices COA – Certificate of Analysis DEG – Diethylene Glycol FDA – Food and Drug Administration FMEA – Failure Mode... process flow diagram should be referenced and methods such as HACCP (Hazard Analysis and Critical Control Point) or FMEA (Failure Mode and Effects Analysis) may be used to help identify critical process points. (IPEC-PQG 2006, 3). For XYZ...

  4. BiotechnologyProfessional Development & Advancement Introduction to BioPharmaceutical Manufacturing

    E-Print Network [OSTI]

    Rhode Island, University of

    -277-5060 (preferred) / Email:bruce_birch@mail.uri.edu The lectures will be held at the URI Feinstein Providence Campus-26, 2014 August 5-7, 2014 Total Registration Fee enclosed: Contact: Bruce Birch: 401-277-5097 Fax: 401 special accommodationsshould indicate so on their registration form (check here ) or call Bruce Birch

  5. Oxidation of advanced steam turbine alloys

    SciTech Connect (OSTI)

    Holcomb, G.R.; Covino, B.S., Jr.; Bullard, S.J.; Ziomek-Moroz, M.

    2006-03-01T23:59:59.000Z

    Advanced or ultra supercritical (USC) steam power plants offer the promise of higher efficiencies and lower emissions. Current goals of the U.S. Department of Energy’s Advanced Power Systems Initiatives include coal generation at 60% efficiency, which would require steam temperatures of up to 760°C. This research examines the steamside oxidation of advanced alloys for use in USC systems, with emphasis placed on alloys for high- and intermediate-pressure turbine sections.

  6. Multi-scale analysis and simulation of powder blending in pharmaceutical manufacturing

    E-Print Network [OSTI]

    Ngai, Samuel S. H

    2005-01-01T23:59:59.000Z

    A Multi-Scale Analysis methodology was developed and carried out for gaining fundamental understanding of the pharmaceutical powder blending process. Through experiment, analysis and computer simulations, microscopic ...

  7. Design of hot extrusion molding device for the continuous production of pharmaceutical tablets

    E-Print Network [OSTI]

    Zampierollo, Giorgio (Giorgio Romano)

    2010-01-01T23:59:59.000Z

    Currently, pharmaceutical tablets are manufactured in large batch operations that have inefficiencies associated with the stopping, re-configuration and testing between batches. Continuous manufacturing has the potential ...

  8. No magic show: Real-world levitation to inspire better pharmaceuticals...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Technology Development & Commercialization is also interested in partnering with the pharmaceutical industry to develop the technology further as well as to license it for...

  9. E-Print Network 3.0 - alternative valproate pharmaceutical Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    rein- forcers and to strengthen executive... is the limited involve- ment of the pharmaceutical industry in the development of new medications. Issues Source: Meagher,...

  10. Assessing nutrient and pharmaceutical removal efficiency from wastewater using shallow wetland treatment mesocosms.

    E-Print Network [OSTI]

    Cardinal, Pascal

    2013-01-01T23:59:59.000Z

    ??Wastewaters from rural sewage lagoons in Manitoba contain pharmaceuticals that are potentially harmful to non-target organisms and reduce overall water quality when released. An option… (more)

  11. Countervailing Power in Wholesale Pharmaceuticals Sara Fisher Ellison Christopher M. Snyder

    E-Print Network [OSTI]

    Lotko, William

    Countervailing Power in Wholesale Pharmaceuticals Sara Fisher Ellison Christopher M. Snyder M liter- ature. We test the theories using data on wholesale prices for antibiotics sold to large

  12. E-Print Network 3.0 - adjuvants pharmaceutic Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A. deusinglaan 1, 9713 AV, Groningen... . deusinglaan 1, 9713 AV, Groningen, the netherlands european Journal of pharmaceutics and Biopharmaceutics (In Source: Groningen,...

  13. Development and Deployment of an Advanced Wind Forecasting Technique

    E-Print Network [OSTI]

    Kemner, Ken

    findings. Part 2 addresses how operators of wind power plants and power systems can incorporate advanced the output of advanced wind energy forecasts into decision support models for wind power plant and power and applications of power market simulation models around the world. Argonne's software tools are used extensively

  14. Advanced Combustion

    SciTech Connect (OSTI)

    Holcomb, Gordon R. [NETL

    2013-03-11T23:59:59.000Z

    The activity reported in this presentation is to provide the mechanical and physical property information needed to allow rational design, development and/or choice of alloys, manufacturing approaches, and environmental exposure and component life models to enable oxy-fuel combustion boilers to operate at Ultra-Supercritical (up to 650{degrees}C & between 22-30 MPa) and/or Advanced Ultra-Supercritical conditions (760{degrees}C & 35 MPa).

  15. ADVANCED TURBINE SYSTEMS PROGRAM

    SciTech Connect (OSTI)

    Gregory Gaul

    2004-04-21T23:59:59.000Z

    Natural gas combustion turbines are rapidly becoming the primary technology of choice for generating electricity. At least half of the new generating capacity added in the US over the next twenty years will be combustion turbine systems. The Department of Energy has cosponsored with Siemens Westinghouse, a program to maintain the technology lead in gas turbine systems. The very ambitious eight year program was designed to demonstrate a highly efficient and commercially acceptable power plant, with the ability to fire a wide range of fuels. The main goal of the Advanced Turbine Systems (ATS) Program was to develop ultra-high efficiency, environmentally superior and cost effective competitive gas turbine systems for base load application in utility, independent power producer and industrial markets. Performance targets were focused on natural gas as a fuel and included: System efficiency that exceeds 60% (lower heating value basis); Less than 10 ppmv NO{sub x} emissions without the use of post combustion controls; Busbar electricity that are less than 10% of state of the art systems; Reliability-Availability-Maintainability (RAM) equivalent to current systems; Water consumption minimized to levels consistent with cost and efficiency goals; and Commercial systems by the year 2000. In a parallel effort, the program was to focus on adapting the ATS engine to coal-derived or biomass fuels. In Phase 1 of the ATS Program, preliminary investigators on different gas turbine cycles demonstrated that net plant LHV based efficiency greater than 60% was achievable. In Phase 2 the more promising cycles were evaluated in greater detail and the closed-loop steam-cooled combined cycle was selected for development because it offered the best solution with least risk for achieving the ATS Program goals for plant efficiency, emissions, cost of electricity and RAM. Phase 2 also involved conceptual ATS engine and plant design and technology developments in aerodynamics, sealing, combustion, cooling, materials, coatings and casting development. The market potential for the ATS gas turbine in the 2000-2014 timeframe was assessed for combined cycle, simple cycle and integrated gasification combined cycle, for three engine sizes. The total ATS market potential was forecasted to exceed 93 GW. Phase 3 and Phase 3 Extension involved further technology development, component testing and W501ATS engine detail design. The technology development efforts consisted of ultra low NO{sub x} combustion, catalytic combustion, sealing, heat transfer, advanced coating systems, advanced alloys, single crystal casting development and determining the effect of steam on turbine alloys. Included in this phase was full-load testing of the W501G engine at the McIntosh No. 5 site in Lakeland, Florida.

  16. Advanced Technology Vehicle Testing

    SciTech Connect (OSTI)

    James Francfort

    2003-11-01T23:59:59.000Z

    The light-duty vehicle transportation sector in the United States depends heavily on imported petroleum as a transportation fuel. The Department of Energy’s Advanced Vehicle Testing Activity (AVTA) is testing advanced technology vehicles to help reduce this dependency, which would contribute to the economic stability and homeland security of the United States. These advanced technology test vehicles include internal combustion engine vehicles operating on 100% hydrogen (H2) and H2CNG (compressed natural gas) blended fuels, hybrid electric vehicles, neighborhood electric vehicles, urban electric vehicles, and electric ground support vehicles. The AVTA tests and evaluates these vehicles with closed track and dynamometer testing methods (baseline performance testing) and accelerated reliability testing methods (accumulating lifecycle vehicle miles and operational knowledge within 1 to 1.5 years), and in normal fleet environments. The Arizona Public Service Alternative Fuel Pilot Plant and H2-fueled vehicles are demonstrating the feasibility of using H2 as a transportation fuel. Hybrid, neighborhood, and urban electric test vehicles are demonstrating successful applications of electric drive vehicles in various fleet missions. The AVTA is also developing electric ground support equipment (GSE) test procedures, and GSE testing will start during the fall of 2003. All of these activities are intended to support U.S. energy independence. The Idaho National Engineering and Environmental Laboratory manages these activities for the AVTA.

  17. Second generation PFB for advanced power generation

    SciTech Connect (OSTI)

    Robertson, A.; Van Hook, J.

    1995-11-01T23:59:59.000Z

    Research is being conducted under a United States Department of Energy (USDOE) contract to develop a new type of coal-fueled plant for electric power generation. This new type of plant-called an advanced or second-generation pressurized fluidized bed combustion (APFBC) plant-offers the promise of 45-percent efficiency (HHV), with emissions and a cost of electricity that are significantly lower than conventional pulverized-coal-fired plants with scrubbers. This paper summarizes the pilot plant R&D work being conducted to develop this new type of plant. Although pilot plant testing is still underway, preliminary estimates indicate the commercial plant Will perform better than originally envisioned. Efficiencies greater than 46 percent are now being predicted.

  18. Plant design: Integrating Plant and Equipment Models

    SciTech Connect (OSTI)

    Sloan, David (Alstrom Power); Fiveland, Woody (Alstrom Power); Zitney, S.E.; Osawe, Maxwell (Ansys, Inc.)

    2007-08-01T23:59:59.000Z

    Like power plant engineers, process plant engineers must design generating units to operate efficiently, cleanly, and profitably despite fluctuating costs for raw materials and fuels. To do so, they increasingly create virtual plants to enable evaluation of design concepts without the expense of building pilot-scale or demonstration facilities. Existing computational models describe an entire plant either as a network of simplified equipment models or as a single, very detailed equipment model. The Advanced Process Engineering Co-Simulator (APECS) project (Figure 5) sponsored by the U.S. Department of Energy's National Energy Technology Laboratory (NETL) seeks to bridge the gap between models by integrating plant modeling and equipment modeling software. The goal of the effort is to provide greater insight into the performance of proposed plant designs. The software integration was done using the process-industry standard CAPE-OPEN (Computer Aided Process Engineering–Open), or CO interface. Several demonstration cases based on operating power plants confirm the viability of this co-simulation approach.

  19. Fee-For-Service Contracts in the Pharmaceutical Industry (Extended Abstract)

    E-Print Network [OSTI]

    Lin, Xiaodong

    Fee-For-Service Contracts in the Pharmaceutical Industry (Extended Abstract) Kathleen Martino and Yao Zhao Starting from 2005, the pharmaceutical industry has experienced a drastic change in the pricing contracts between manufacturers and distributors as the industry moved from the dominating Buy

  20. ocietal pressures to reduce healthcare costs, coupled with the pharmaceutical industry's need to maintain its eco-

    E-Print Network [OSTI]

    Peng, Yun

    ocietal pressures to reduce healthcare costs, coupled with the pharmaceutical industry's need. Augsburger, PhD, is Shangraw Professor of Industrial Pharmacy and Pharmaceutics, all in the Department to maintain its eco- nomic incentive to develop new drugs, have required that the industry increase speed

  1. Pharmaceuticals in wastewater: Behavior, preferences, and willingness to pay for a disposal program

    E-Print Network [OSTI]

    Kotchen, Matthew J.

    Pharmaceuticals in wastewater: Behavior, preferences, and willingness to pay for a disposal program Contingent valuation Willingness to pay Wastewater a b s t r a c t The presence of pharmaceutical compounds in treated wastewater and in surface waters is a growing environmental concern. This paper provides

  2. Approved Module Information for PH3704, 2014/5 Module Title/Name: Quality Assured Pharmaceutical

    E-Print Network [OSTI]

    Neirotti, Juan Pablo

    and processes, including the use of Standard Operating Procedures, Good Laboratory Practice, Good Pharmaceutical Technology Module Code: PH3704 School: Life and Health Sciences Module Type: Standard Module New Module of these materials. · To describe the role of quality assurance in the maintenance of the quality of pharmaceutical

  3. Advanced Combustion

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth (AOD)ProductssondeadjustsondeadjustAbout the Building TechnologiesS1!4T opAddress:AdolphusAdvanced Energy

  4. This program prepares you for careers in the pharmaceutical, consumer products, and healthcare industries. As a Pharmaceutical Science graduate, you are qualified to seek a diverse range of career options, including research and

    E-Print Network [OSTI]

    Rhode Island, University of

    industries. As a Pharmaceutical Science graduate, you are qualified to seek a diverse range of career options the pharmaceutical industry, in addition to careers in research and regulatory oversight within government agenciesThis program prepares you for careers in the pharmaceutical, consumer products, and healthcare

  5. Advanced Vehicle Testing & Evaluation

    Broader source: Energy.gov (indexed) [DOE]

    Provide benchmark data for advanced technology vehicles Develop lifecycle cost data for production vehicles utilizing advanced power trains Provide fleet...

  6. Chemistry Page 83Sonoma State University 2011-2012 Catalog rate for acceptance into advanced degree programs in chemistry

    E-Print Network [OSTI]

    Ravikumar, B.

    Chemistry Page 83Sonoma State University 2011-2012 Catalog rate for acceptance into advanced degree programs in chemistry and biochemistry; medical, dental, and veterinary schools; cell and molecular biology, space chemistry, teaching at all levels, medical technology, pharmaceuticals, patent law, materials

  7. Advanced LIGO

    E-Print Network [OSTI]

    The LIGO Scientific Collaboration

    2014-11-17T23:59:59.000Z

    The Advanced LIGO gravitational wave detectors are second generation instruments designed and built for the two LIGO observatories in Hanford, WA and Livingston, LA. The two instruments are identical in design, and are specialized versions of a Michelson interferometer with 4 km long arms. As in initial LIGO, Fabry-Perot cavities are used in the arms to increase the interaction time with a gravitational wave, and power recycling is used to increase the effective laser power. Signal recycling has been added in Advanced LIGO to improve the frequency response. In the most sensitive frequency region around 100 Hz, the design strain sensitivity is a factor of 10 better than initial LIGO. In addition, the low frequency end of the sensitivity band is moved from 40 Hz down to 10 Hz. All interferometer components have been replaced with improved technologies to achieve this sensitivity gain. Much better seismic isolation and test mass suspensions are responsible for the gains at lower frequencies. Higher laser power, larger test masses and improved mirror coatings lead to the improved sensitivity at mid- and high- frequencies. Data collecting runs with these new instruments are planned to begin in mid-2015.

  8. Bio-pharmaceutical entrepreneurship in two Japanese and French bio-clusters: differences in founder's profiles and experience.

    E-Print Network [OSTI]

    Boyer, Edmond

    breakthroughs, a new type of firm has emerged in the pharmaceutical industry, called the New Biotechnology FirmBio-pharmaceutical entrepreneurship in two Japanese and French bio- clusters: differences academia to the pharmaceutical market and facilitate technological incursions into drug development

  9. Advanced control documentation for operators

    SciTech Connect (OSTI)

    Ayral, T.E. (Mobil Oil, Torrance, CA (US)); Conley, R.C. (Profimatics, Inc., Thousand Oaks, CA (US)); England, J.; Antis, K. (Ashland Oil, Ashland, KY (US))

    1988-09-01T23:59:59.000Z

    Advanced controls were implemented on Ashland Oil's Reduced Crude Conversion (RCC) and Metals Removal System (MRS) units, the RCC and MRS main fractionators and the unit gas plant. This article describes the format used for the operator documentation at Ashland. Also, a potential process unit problem is described which can be solved by good operator documentation. The situation presented in the paper is hypothetical, however,the type of unit upset described an occur if proper precautions are not taken.

  10. Advanced Hydrogen Turbine Development

    SciTech Connect (OSTI)

    Joesph Fadok

    2008-01-01T23:59:59.000Z

    Siemens has developed a roadmap to achieve the DOE goals for efficiency, cost reduction, and emissions through innovative approaches and novel technologies which build upon worldwide IGCC operational experience, platform technology, and extensive experience in G-class operating conditions. In Phase 1, the technologies and concepts necessary to achieve the program goals were identified for the gas turbine components and supporting technology areas and testing plans were developed to mitigate identified risks. Multiple studies were conducted to evaluate the impact in plant performance of different gas turbine and plant technologies. 2015 gas turbine technologies showed a significant improvement in IGCC plant efficiency, however, a severe performance penalty was calculated for high carbon capture cases. Thermodynamic calculations showed that the DOE 2010 and 2015 efficiency targets can be met with a two step approach. A risk management process was instituted in Phase 1 to identify risk and develop mitigation plans. For the risks identified, testing and development programs are in place and the risks will be revisited periodically to determine if changes to the plan are necessary. A compressor performance prediction has shown that the design of the compressor for the engine can be achieved with additional stages added to the rear of the compressor. Tip clearance effects were studied as well as a range of flow and pressure ratios to evaluate the impacts to both performance and stability. Considerable data was obtained on the four candidate combustion systems: diffusion, catalytic, premix, and distributed combustion. Based on the results of Phase 1, the premixed combustion system and the distributed combustion system were chosen as having the most potential and will be the focus of Phase 2 of the program. Significant progress was also made in obtaining combustion kinetics data for high hydrogen fuels. The Phase 1 turbine studies indicate initial feasibility of the advanced hydrogen turbine that meets the aggressive targets set forth for the advanced hydrogen turbine, including increased rotor inlet temperature (RIT), lower total cooling and leakage air (TCLA) flow, higher pressure ratio, and higher mass flow through the turbine compared to the baseline. Maintaining efficiency with high mass flow Syngas combustion is achieved using a large high AN2 blade 4, which has been identified as a significant advancement beyond the current state-of-the-art. Preliminary results showed feasibility of a rotor system capable of increased power output and operating conditions above the baseline. In addition, several concepts were developed for casing components to address higher operating conditions. Rare earth modified bond coat for the purpose of reducing oxidation and TBC spallation demonstrated an increase in TBC spallation life of almost 40%. The results from Phase 1 identified two TBC compositions which satisfy the thermal conductivity requirements and have demonstrated phase stability up to temperatures of 1850 C. The potential to join alloys using a bonding process has been demonstrated and initial HVOF spray deposition trials were promising. The qualitative ranking of alloys and coatings in environmental conditions was also performed using isothermal tests where significant variations in alloy degradation were observed as a function of gas composition. Initial basic system configuration schematics and working system descriptions have been produced to define key boundary data and support estimation of costs. Review of existing materials in use for hydrogen transportation show benefits or tradeoffs for materials that could be used in this type of applications. Hydrogen safety will become a larger risk than when using natural gas fuel as the work done to date in other areas has shown direct implications for this type of use. Studies were conducted which showed reduced CO{sub 2} and NOx emissions with increased plant efficiency. An approach to maximize plant output is needed in order to address the DOE turbine goal for 20-30% reduction o

  11. Proposed Action Title: (0470-1517) Donald Danforth Plant Science...

    Broader source: Energy.gov (indexed) [DOE]

    Title: (0470-1517) Donald Danforth Plant Science Center - Center for Enahnced Camelina Oil Program or Field Office: Advanced Research Projects Agency - Energy Location(s) (City...

  12. ADVANCED SULFUR CONTROL CONCEPTS

    SciTech Connect (OSTI)

    Apostolos A. Nikolopoulos; Santosh K. Gangwal; William J. McMichael; Jeffrey W. Portzer

    2003-01-01T23:59:59.000Z

    Conventional sulfur removal in integrated gasification combined cycle (IGCC) power plants involves numerous steps: COS (carbonyl sulfide) hydrolysis, amine scrubbing/regeneration, Claus process, and tail-gas treatment. Advanced sulfur removal in IGCC systems involves typically the use of zinc oxide-based sorbents. The sulfides sorbent is regenerated using dilute air to produce a dilute SO{sub 2} (sulfur dioxide) tail gas. Under previous contracts the highly effective first generation Direct Sulfur Recovery Process (DSRP) for catalytic reduction of this SO{sub 2} tail gas to elemental sulfur was developed. This process is currently undergoing field-testing. In this project, advanced concepts were evaluated to reduce the number of unit operations in sulfur removal and recovery. Substantial effort was directed towards developing sorbents that could be directly regenerated to elemental sulfur in an Advanced Hot Gas Process (AHGP). Development of this process has been described in detail in Appendices A-F. RTI began the development of the Single-step Sulfur Recovery Process (SSRP) to eliminate the use of sorbents and multiple reactors in sulfur removal and recovery. This process showed promising preliminary results and thus further process development of AHGP was abandoned in favor of SSRP. The SSRP is a direct Claus process that consists of injecting SO{sub 2} directly into the quenched coal gas from a coal gasifier, and reacting the H{sub 2}S-SO{sub 2} mixture over a selective catalyst to both remove and recover sulfur in a single step. The process is conducted at gasifier pressure and 125 to 160 C. The proposed commercial embodiment of the SSRP involves a liquid phase of molten sulfur with dispersed catalyst in a slurry bubble-column reactor (SBCR).

  13. Insights into the issues facing pharmaceutical companies for information provision: a report on the P-D-R special meeting, La Grande Motte, 28-29

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    the pharmaceutical industry. The pharmaceutical industry is the only corporate sector with a long and profitable1 Insights into the issues facing pharmaceutical companies for information provision: a report: The article reports on the use of primary information in pharmaceutical companies, on global services arising

  14. Product traceability in the pharmaceutical supply chain : an analysis of the auto-ID approach

    E-Print Network [OSTI]

    Bellman, Attilio, 1967-

    2003-01-01T23:59:59.000Z

    This thesis analyzes how the Auto-ID technology and information infrastructure will change the management and distribution of pharmaceutical products within the health care industry by enabling item level product traceability ...

  15. The development of a thin-film rollforming process for pharmaceutical continuous manufacturing

    E-Print Network [OSTI]

    Slaughter, Ryan (Ryan R.)

    2013-01-01T23:59:59.000Z

    In this thesis, a continuous rollforming process for the folding of thin-films was proposed and studied as a key step in the continuous manufacturing of pharmaceutical tablets. HPMC and PEG based polymeric thin-films were ...

  16. The effect of die geometry on extruded paste flow for continuous production of pharmaceutical tablets

    E-Print Network [OSTI]

    Nagaraj, Aditi

    2011-01-01T23:59:59.000Z

    The design of an extruder-based continuous tablet forming process of a sample active pharmaceutical ingredient (API) and ethyl acetate requires a device to form and compress the tablets. The flow of the wet extrusion is ...

  17. Pharmaceutical R&D : an organizational design approach to enhancing productivity

    E-Print Network [OSTI]

    Adeusi, Sunny O. (Sunday Oluwasogo)

    2011-01-01T23:59:59.000Z

    The pharmaceutical industry is an $837 billion a year industry that is being plagued by low R&D productivity. This decline in productivity has resulted in significant erosion of value. From December 2000 to February 2008, ...

  18. A root cause analysis of stock-outs in the pharmaceutical industry

    E-Print Network [OSTI]

    Sun, Xuewen, M. Eng. Massachusetts Institute of Technology

    2014-01-01T23:59:59.000Z

    PharCo (an assumed name) is a leading global healthcare company with well-recognized brands of both pharmaceutical and consumer healthcare products. As PharCo continues to expand its global presence, product stock-outs in ...

  19. Optimal handling of Highly Active Pharmaceutical Ingredients during milling and blending operations

    E-Print Network [OSTI]

    Setty, Prashant (Prashant Neelappanavara)

    2013-01-01T23:59:59.000Z

    This thesis investigates best practices for Highly Active Pharmaceutical Ingredient (HAPI) milling and blending. We utilize a qualitative analysis centering on a benchmarking study and quantitative analyses using a ...

  20. Improving energy efficiency in a pharmaceutical manufacturing environment : analysis of EUI and cooling load

    E-Print Network [OSTI]

    Liu, Haoyu

    2009-01-01T23:59:59.000Z

    Reducing energy consumption without compromising the quality of products and the comfort of occupants is important in maintaining the competence of a pharmaceutical company. An energy management tool is developed to monitor ...

  1. The production planning and inventory management of intermediate products for a pharmaceutical company

    E-Print Network [OSTI]

    Kok, Yixiong

    2007-01-01T23:59:59.000Z

    TCG is a multinational pharmaceutical company. As part of its drive to stay lean and competitive, TCG hopes to effectively maximize its capital assets by reducing warehouse inventory. This thesis aims to reduce the inventory ...

  2. Healthcare reform in the United States and China: pharmaceutical market implications

    E-Print Network [OSTI]

    Daemmrich, Arthur; Mohanty, Ansuman

    2014-07-14T23:59:59.000Z

    . This article analyzes the implications of health system reforms in the United States and China for national pharmaceutical markets. It follows a historical institutionalist approach that identifies path dependency in the design and operation of national health...

  3. INVESTIGATING PHARMACEUTICAL CO-CRYSTALS AS A MEANS TO IMPROVE THE SOLUBILITY OF A DRUG

    E-Print Network [OSTI]

    Brown, Rebecca Anderson

    2012-05-31T23:59:59.000Z

    Recently co-crystals have emerged as a potential approach to improve the solubility, dissolution, and bioavailability of active pharmaceutical ingredients (API). Often co-crystal formation is studied in the development stage in order to solve...

  4. The Vaporization Enthalpies and Vapor Pressures of Some Primary Amines of Pharmaceutical Importance by Correlation Gas

    E-Print Network [OSTI]

    Chickos, James S.

    by Correlation Gas Chromatography Chase Gobble, Nigam Rath, and James Chickos* Department of Chemistry Information ABSTRACT: Vapor pressures, vaporization, and sublimation enthalpies of several pharmaceuticals and boiling temperatures when available. Sublimation enthalpies and vapor pressures are also evaluated for 1

  5. Inventory strategies for patented and generic products for a pharmaceutical supply chain

    E-Print Network [OSTI]

    Krishnamurthy, Prashanth, M. Eng. Massachusetts Institute of Technology

    2012-01-01T23:59:59.000Z

    This thesis presents a model to determine safety stock considering the distinct planning parameters for a pharmaceutical company. Traditional parameters such as forecast accuracy, service level requirements and average ...

  6. Technological learning and the evolution of the Indian pharmaceutical and biopharmaceutical sectors

    E-Print Network [OSTI]

    Srinivas, Smita

    2004-01-01T23:59:59.000Z

    The Indian pharmaceutical and biopharmaceutical sectors have been characterised by three features considered analogous to technological stagnation: low R&D investments, "copying" on-patent drugs (legal in India if a novel ...

  7. Strategic Entry Deterrence and the Behavior of Pharmaceutical Incumbents Prior to Patent Expiration

    E-Print Network [OSTI]

    Ellison, Glenn

    This paper develops a new approach to testing for strategic entry deterrence and applies it to the behavior of pharmaceutical incumbents before patent expiration. It examines a cross section of markets, determining whether ...

  8. Hydroxymethyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals and method of making same

    DOE Patents [OSTI]

    Katti, Kattesh V. (Columbia, MO); Karra, Srinivasa Rao (Columbia, MO); Berning, Douglas E. (Columbia, MO); Smith, C. Jeffrey (Columbia, MO); Volkert, Wynn A. (Columbia, MO); Ketring, Alan R. (Columbia, MO)

    1999-01-01T23:59:59.000Z

    A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises at least one functionalized hydroxyalkyl phosphine donor group and one or more sulfur or nitrogen donor and a metal combined with the ligand.

  9. Hydroxymethyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals and method of making same

    DOE Patents [OSTI]

    Katti, Kattesh V. (Columbia, MO); Karra, Srinivasa Rao (Columbia, MO); Berning, Douglas E. (Columbia, MO); Smith, C. Jeffrey (Columbia, MO); Volkert, Wynn A. (Columbia, MO); Ketring, Alan R. (Columbia, MO)

    2000-01-01T23:59:59.000Z

    A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises at least one functionalized hydroxyalkyl phosphine donor group and one or more sulfur or nitrogen donor and a metal combined with the ligand.

  10. The bicyclic amine that is the precursor to ~ $4 billion pharmaceutical industries

    E-Print Network [OSTI]

    Rzepa, Henry S.

    Tropane The bicyclic amine that is the precursor to ~ $4 billion pharmaceutical industries Quazi is a bicyclic amine that has a pyrrolidine and a piperidine ring sharing a common nitrogen atom and 2 carbon

  11. INSIDE Waitt Advanced Biophotonics Center Grand Opening One on One with...Thomas Albright REMEMBERINGWylie

    E-Print Network [OSTI]

    Bellugi, Ursula

    INSIDE » Waitt Advanced Biophotonics Center Grand Opening » One on One with...Thomas Albright Discovery of plant proteins may boost agricultural yields and biofuel production 20 Complex wiring

  12. Solar Thermochemical Advanced Reactor System, Wins R&D 100 Award...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    National Laboratory, the Solar Thermochemical Advanced Reactor System, or STARS, converts natural gas and sunlight into a more energy-rich fuel called syngas, which power plants...

  13. DOE Announces Transfer of Depleted Uranium to Advance the U.S...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Transfer of Depleted Uranium to Advance the U.S. National Security Interests, Extend Operations at Paducah Gaseous Diffusion Plant DOE Announces Transfer of Depleted Uranium to...

  14. E-Print Network 3.0 - advanced aqueous reprocessing Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cecil and Ida Green... then there have been major advances in our understanding of uranium geology. Because of the importance of uranium... plants are being planned, and...

  15. Ash Chemistry in MSW Incineration Plants

    E-Print Network [OSTI]

    Ash Chemistry in MSW Incineration Plants: Advanced Characterization and Thermodynamic to analyze MSW-derived ashes by use of CCSEM. Representative samples of 2nd -3rd pass and ESP/E-filter ashes

  16. Phytoplankton consists of one-celled marine and freshwater microalgae and other plant-like organisms.

    E-Print Network [OSTI]

    Florida, University of

    Phytoplankton consists of one-celled marine and freshwater microalgae and other plant-like organisms. They are used in the production of pharmaceuticals, diet supplements, pigments, and biofuels, taking up carbon dioxide and nutrients from the water and using light as an energy source. The microalgae

  17. advanced coal conversion: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the coal plant is transmitted over the transmission lines, Phadke, Amol 2008-01-01 7 Clean Coal Technology Program Advanced Coal Conversion Process Demonstration CiteSeer Summary:...

  18. Advanced Characterisation of Municipal Solid Waste Ashes

    E-Print Network [OSTI]

    Advanced Characterisation of Municipal Solid Waste Ashes Preparatory thesis Randi Skytte Pedersen is to investigate Municipal Solid Waste (MSW) ashes with respect to particle sizes, structures and composition with characterisation of Municipal Solid Waste (MSW) ashes from the Danish power plant M°abjergværket, Holstebro. MSW

  19. Advanced Process and Chemical Complex Analysis Systems Derya Ozyurtb

    E-Print Network [OSTI]

    Pike, Ralph W.

    157g Advanced Process and Chemical Complex Analysis Systems Derya Ozyurtb , Aimin Xub , Thomas for statements or opinions contained in papers or printed in its publications. #12;Abstract: The Advanced Process Analysis System is used to perform economic and environmental evaluations of a plant. The main components

  20. Next Generation Geothermal Power Plants

    SciTech Connect (OSTI)

    Brugman, John; Hattar, Mai; Nichols, Kenneth; Esaki, Yuri

    1995-09-01T23:59:59.000Z

    A number of current and prospective power plant concepts were investigated to evaluate their potential to serve as the basis of the next generation geothermal power plant (NGGPP). The NGGPP has been envisaged as a power plant that would be more cost competitive (than current geothermal power plants) with fossil fuel power plants, would efficiently use resources and mitigate the risk of reservoir under-performance, and minimize or eliminate emission of pollutants and consumption of surface and ground water. Power plant concepts were analyzed using resource characteristics at ten different geothermal sites located in the western United States. Concepts were developed into viable power plant processes, capital costs were estimated and levelized busbar costs determined. Thus, the study results should be considered as useful indicators of the commercial viability of the various power plants concepts that were investigated. Broadly, the different power plant concepts that were analyzed in this study fall into the following categories: commercial binary and flash plants, advanced binary plants, advanced flash plants, flash/binary hybrid plants, and fossil/geothed hybrid plants. Commercial binary plants were evaluated using commercial isobutane as a working fluid; both air-cooling and water-cooling were considered. Advanced binary concepts included cycles using synchronous turbine-generators, cycles with metastable expansion, and cycles utilizing mixtures as working fluids. Dual flash steam plants were used as the model for the commercial flash cycle. The following advanced flash concepts were examined: dual flash with rotary separator turbine, dual flash with steam reheater, dual flash with hot water turbine, and subatmospheric flash. Both dual flash and binary cycles were combined with other cycles to develop a number of hybrid cycles: dual flash binary bottoming cycle, dual flash backpressure turbine binary cycle, dual flash gas turbine cycle, and binary gas turbine cycle. Results of this study indicate that dual flash type plants are preferred at resources with temperatures above 400 F. Closed loop (binary type) plants are preferred at resources with temperatures below 400 F. A rotary separator turbine upstream of a dual flash plant can be beneficial at Salton Sea, the hottest resource, or at high temperature resources where there is a significant variance in wellhead pressures from well to well. Full scale demonstration is required to verify cost and performance. Hot water turbines that recover energy from the spent brine in a dual flash cycle improve that cycle's brine efficiency. Prototype field tests of this technology have established its technical feasibility. If natural gas prices remain low, a combustion turbine/binary hybrid is an economic option for the lowest temperature sites. The use of mixed fluids appear to be an attractive low risk option. The synchronous turbine option as prepared by Barber-Nichols is attractive but requires a pilot test to prove cost and performance. Dual flash binary bottoming cycles appear promising provided that scaling of the brine/working fluid exchangers is controllable. Metastable expansion, reheater, Subatmospheric flash, dual flash backpressure turbine, and hot dry rock concepts do not seem to offer any cost advantage over the baseline technologies. If implemented, the next generation geothermal power plant concept may improve brine utilization but is unlikely to reduce the cost of power generation by much more than 10%. Colder resources will benefit more from the development of a next generation geothermal power plant than will hotter resources. All values presented in this study for plant cost and for busbar cost of power are relative numbers intended to allow an objective and meaningful comparison of technologies. The goal of this study is to assess various technologies on an common basis and, secondarily, to give an approximate idea of the current costs of the technologies at actual resource sites. Absolute costs at a given site will be determined by the specifics of a given pr

  1. The effects of vendor and quality control variability in the procurement of raw materials in a bio-pharmaceutical company

    E-Print Network [OSTI]

    Wheeler, Jake T

    2011-01-01T23:59:59.000Z

    Pharmaceutical companies have traditionally placed little emphasis on supply chain efficiencies and operations costs. With the changing landscape of expiring intellectual property rights and increased market segmentation, ...

  2. Improved Economics of Nuclear Plant Life Management

    SciTech Connect (OSTI)

    Bond, Leonard J.; Doctor, Steven R.; Jarrell, Donald B.; Bond, Joseph W D.

    2007-07-31T23:59:59.000Z

    The adoption of new on-line monitoring, diagnostic and eventually prognostics technologies has the potential to impact the economics of the existing nuclear power plant fleet, new plants and future advanced designs. To move from periodic inspection to on-line monitoring for condition based maintenance and eventually prognostics will require advances in sensors, better understanding of what and how to measure within the plant; enhanced data interrogation, communication and integration; new predictive models for damage/aging evolution; system integration for real world deployments; quantification of uncertainties in what are inherently ill-posed problems and integration of enhanced condition based maintenance/prognostics philosophies into new plant designs, operation and O&M approaches. The move to digital systems in petrochemical, process and fossil fuel power plants is enabling major advances to occur in the instrumentation, controls and monitoring systems and approaches employed. The adoption within the nuclear power community of advanced on-line monitoring and advanced diagnostics has the potential for the reduction in costly periodic surveillance that requires plant shut-down , more accurate cost-benefit analysis, “just-in-time” maintenance, pre-staging of maintenance tasks, move towards true “operation without failures” and a jump start on advanced technologies for new plant concepts, such as those under the International Gen IV Program. There are significant opportunities to adopt condition-based maintenance when upgrades are implemented at existing facilities. The economic benefit from a predictive maintenance program based upon advanced on-line monitoring and advanced diagnostics can be demonstrated from a cost/benefit analysis. An analysis of the 104 US legacy systems has indicated potential savings at over $1B per year when applied to all key equipment; a summary of the supporting analysis is provided in this paper.

  3. Developer Installed Treatment Plants

    E-Print Network [OSTI]

    unknown authors

    2008-01-01T23:59:59.000Z

    -installed treatment plants. These treatment plants are more commonly known as package wastewater treatment plants. 1

  4. Proceedings: EPRI Manufactured Gas Plants 2003 Forum

    SciTech Connect (OSTI)

    None

    2004-02-01T23:59:59.000Z

    The EPRI Manufactured Gas Plants 2003 Forum covered a range of topics related to remediation and management of former manufactured gas plant (MGP) sites, with emphasis on technological advances and current issues associated with site cleanup. In specific, the forum covered MGP coal-tar delineation, soil and groundwater remediation technologies, improvements in air monitoring, and ecological risk characterization/risk management tools.

  5. TECHNICAL ADVANCE EVE (external variance estimation) increases statistical power

    E-Print Network [OSTI]

    Buehlmann, Peter

    TECHNICAL ADVANCE EVE (external variance estimation) increases statistical power for detecting Institute of Plant Sciences & Zurich­Basel Plant Science Center, ETH Zurich, CH-8092 Zurich, Switzerland, our simulation studies suggest that even limited numbers of replicates will usually result in good

  6. Advanced Critical Advanced Energy Retrofit Education and Training...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Critical Advanced Energy Retrofit Education and Training and Credentialing - 2014 BTO Peer Review Advanced Critical Advanced Energy Retrofit Education and Training and...

  7. Advanced nuclear fuel

    ScienceCinema (OSTI)

    Terrani, Kurt

    2014-07-15T23:59:59.000Z

    Kurt Terrani uses his expertise in materials science to develop safer fuel for nuclear power plants.

  8. Advanced nuclear fuel

    SciTech Connect (OSTI)

    Terrani, Kurt

    2014-07-14T23:59:59.000Z

    Kurt Terrani uses his expertise in materials science to develop safer fuel for nuclear power plants.

  9. Italian Academy Advanced Studies

    E-Print Network [OSTI]

    Qian, Ning

    The Italian Academy for Advanced Studies in America at Columbia University Annual Report 2006­2007 The Italian Academy for Advanced Studies in America at Columbia University Annual Report 2006­2007 #12;italian academy for advanced studies in america 1161 Amsterdam Avenue New York, NY 10027 tel: (212) 854-2306 fax

  10. Advanced Search Search Tips

    E-Print Network [OSTI]

    Kinosita Jr., Kazuhiko

    Advanced Search Search Tips Advanced Search Search Tips springerlink.com SpringerLink 2,000 40,000 20,000 2010 11 Please visit 7 http://www.springerlink.com GO 1997 1997 SpringerLink Advanced Search Search Tips CONTENT DOI CITATION DOI ISSN ISBN CATEGORY AND DATE LIMITERS Journals Books Protocols

  11. THE ARIES-CS COMPACT STELLARATOR FUSION POWER PLANT

    E-Print Network [OSTI]

    Raffray, A. René

    THE ARIES-CS COMPACT STELLARATOR FUSION POWER PLANT F. NAJMABADI* and A. R. RAFFRAY Center stellarator power plants, ARIES-CS, has been conducted to explore attrac- tive compact stellarator by earlier stellarator power plant studies had led to cost projections much higher than those of the advanced

  12. Advanced Geothermal Turbodrill

    SciTech Connect (OSTI)

    W. C. Maurer

    2000-05-01T23:59:59.000Z

    Approximately 50% of the cost of a new geothermal power plant is in the wells that must be drilled. Compared to the majority of oil and gas wells, geothermal wells are more difficult and costly to drill for several reasons. First, most U.S. geothermal resources consist of hot, hard crystalline rock formations which drill much slower than the relatively soft sedimentary formations associated with most oil and gas production. Second, high downhole temperatures can greatly shorten equipment life or preclude the use of some technologies altogether. Third, producing viable levels of electricity from geothermal fields requires the use of large diameter bores and a high degree of fluid communication, both of which increase drilling and completion costs. Optimizing fluid communication often requires creation of a directional well to intersect the best and largest number of fracture capable of producing hot geothermal fluids. Moineau motor stators made with elastomers cannot operate at geothermal temperatures, so they are limited to the upper portion of the hole. To overcome these limitations, Maurer Engineering Inc. (MEI) has developed a turbodrill that does not use elastomers and therefore can operate at geothermal temperatures. This new turbodrill uses a special gear assembly to reduce the output speed, thus allowing a larger range of bit types, especially tri-cone roller bits, which are the bits of choice for drilling hard crystalline formations. The Advanced Geothermal Turbodrill (AGT) represents a significant improvement for drilling geothermal wells and has the potential to significantly reduce drilling costs while increasing production, thereby making geothermal energy less expensive and better able to compete with fossil fuels. The final field test of the AGT will prepare the tool for successful commercialization.

  13. This document is a template memorandum of understanding ("MOU") between the National Institutes of Health ("NIH") and collaborating pharmaceutical companies in the NIH-Industry

    E-Print Network [OSTI]

    Bandettini, Peter A.

    of Health ("NIH") and collaborating pharmaceutical companies in the NIH-Industry Pilot Program: Discovering NCATS intends to work with experts in academia and the biotechnology and pharmaceutical industries the NIH and the specific collaborating pharmaceutical companies, this template MOU expresses the general

  14. The Blanche and Irwin Lerner Center for the Study of Pharmaceutical Management Issues 1 Washington Park, #1125B, Newark, NJ 07102

    E-Print Network [OSTI]

    Lin, Xiaodong

    was Regulations and Reimbursements: Trends and Issues Facing the Bio-Pharmaceutical Industry. The Keynote Speaker as an educational conduit between the pharmaceutical industry, the University and various other organizations facing the pharmaceutical, biotech and healthcare industries. · On-site customized executive training

  15. The Blanche and Irwin Lerner Center for the Study of Pharmaceutical Management Issues 1 Washington Park, #1125B Newark, NJ 07102

    E-Print Network [OSTI]

    Lin, Xiaodong

    as an educational conduit between the pharmaceutical industry, the University and various other organizations facing the pharmaceutical, biotech and healthcare industries. On-site customized executive trainingThe Blanche and Irwin Lerner Center for the Study of Pharmaceutical Management Issues 1 Washington

  16. "New Jersey is the pharmaceutical capital of the country and Rutgers is at the center of it all," says Marc Paolantonio. After receiving his under-

    E-Print Network [OSTI]

    Lin, Xiaodong

    's most respected and socially beneficial industries. Industry Scholars The Rutgers MBA in pharmaceutical, Regulatory, and Ethical Issues in the Pharmaceutical Industry, a course devel- oped by Professor Michael Prices Too High? hosted by Johnson & Johnson-Ortho Biotech Investing in the Pharmaceutical Industry

  17. Pharmaceutical Supply Chain Networks with Outsourcing Under Price and Quality Competition

    E-Print Network [OSTI]

    Nagurney, Anna

    Isenberg School of Management University of Massachusetts, Amherst, Massachusetts 01003 2 School and distribution. In addition to multimarket demand satisfaction, the pharmaceutical firm seeks to minimize its #12;1. Introduction Outsourcing is defined as the behavior of moving some of a firm's responsibilities

  18. Raspberry derived mesoporous carbon-tubules and fixed-bed adsorption of pharmaceutical drugs

    E-Print Network [OSTI]

    Ma, Lena

    Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing (Innovation Centre for Safety and Material Technology, TUMA), 50130 Mikkeli, Finland d Soil and Water Science Department, University of Florida, Gainesville, FL 32611-0290, USA 1. Introduction Pharmaceutical drugs (PD

  19. To: University of Utah Research and Pharmaceutical Departments From: Michael Smith-Buyer

    E-Print Network [OSTI]

    van den Berg, Jur

    -Buyer Date: April 23, 2012 Subject: Autodial Alarm Devices for Cooling Units Which Store Research requires that all cooling units containing research or pharmaceutical materials be equipped with autodial temperature change. These are remote alarms that will call a number of phone numbers in an attempt to notify

  20. Contamination levels of human pharmaceutical compounds in French surface and drinking water

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    -west France. 98 samples were analysed from 63 stations (surface water and drinking water produced from surfaceContamination levels of human pharmaceutical compounds in French surface and drinking water S therapeutic classes was analysed from resource and drinking water in two catchment basins located in north

  1. Hydroxymethyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals and method of making same

    DOE Patents [OSTI]

    Katti, K.V.; Karra, S.R.; Berning, D.E.; Smith, C.J.; Volkert, W.A.; Ketring, A.R.

    1999-01-05T23:59:59.000Z

    A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises at least one functionalized hydroxyalkyl phosphine donor group and one or more sulfur or nitrogen donor and a metal combined with the ligand. 21 figs.

  2. Hydroxyalkyl phosphine gold complexes for use as diagnostic and therapeutic pharmaceuticals and method of making same

    DOE Patents [OSTI]

    Katti, K.V.; Berning, D.E.; Volkert, W.A.; Ketring, A.R.

    1998-12-01T23:59:59.000Z

    A complex and method for making a diagnostic or therapeutic pharmaceutical includes a ligand comprising at least one hydroxyalkyl phosphine donor group bound to a gold atom to form a gold-ligand complex that is stable in aqueous solutions containing oxygen, serum and other body fluids. 20 figs.

  3. DEVELOPMENT OF MULTIPLE SAMPLE SOLID-STATE NMR PROBES FOR ANALYSIS OF PHARMACEUTICAL COMPOUNDS AND FORMULATIONS

    E-Print Network [OSTI]

    Nelson, Benjamin Nels

    2011-12-31T23:59:59.000Z

    Solid-state NMR spectroscopy (ssNMR) is an extremely powerful technique for the analysis of pharmaceutical dosage forms. A major limitation of ssNMR is the number of samples that can be analyzed in a given period of time. ...

  4. Hydroxyalkyl phosphine gold complexes for use as diagnostic and therapeutic pharmaceuticals and method of making same

    DOE Patents [OSTI]

    Katti, Kattesh V. (Columbia, MO); Berning, Douglas E. (Columbia, MO); Volkert, Wynn A. (Columbia, MO); Ketring, Alan R. (Columbia, MO)

    1998-01-01T23:59:59.000Z

    A complex and method for making same for use as a diagnostic or therapeutic pharmaceutical includes a ligand comprising at least one hydroxyalkyl phosphine donor group bound to a gold atom to form a gold-ligand complex that is stable in aqueous solutions containing oxygen, serum and other body fluids.

  5. E-Print Network 3.0 - automobile manufacturing plant Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Search Powered by Explorit Topic List Advanced Search Sample search results for: automobile manufacturing plant Page: << < 1 2 3 4 5 > >> 1 Welding Technology Program Director:...

  6. MWM-Array Sensors for In Situ Monitoring of High-Temperature Components in Power Plants

    E-Print Network [OSTI]

    Sheiretov, Yanko

    Utilization of America's substantial coal reserves for energy production has become a national priority. Advanced coal-fired power plants offer an environmentally friendly means to achieve that goal. These power plants, ...

  7. E-Print Network 3.0 - aquatic plant exudates Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    by Explorit Topic List Advanced Search Sample search results for: aquatic plant exudates Page: << < 1 2 3 4 5 > >> 1 Plant and Soil 222: 191202, 2000. 2000 Kluwer Academic...

  8. E-Print Network 3.0 - affects cotton plant Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    cotton plant Search Powered by Explorit Topic List Advanced Search Sample search results for: affects cotton plant Page: << < 1 2 3 4 5 > >> 1 Course Description Form Department or...

  9. Advanced Studies Institute

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Engineering Institute Advanced Studies Institute Contact Institute Director Charles Farrar (505) 663-5330 Email UCSD EI Director Michael Todd (858) 534-5951 Professional Staff...

  10. Advanced Reciprocating Engine Systems

    Broader source: Energy.gov [DOE]

    The Advanced Reciprocating Engine Systems (ARES) program is designed to promote separate but parallel engine development between the major stationary, gaseous fueled engine manufacturers in the...

  11. Advanced Propulsion Technology Strategy

    Broader source: Energy.gov (indexed) [DOE]

    Alternative Sources) Hydrogen Time ADVANCED PROPULSION TECHNOLOGY STRATEGY DOWNSIZED TURBO GAS ENGINE CHEVROLET CRUZE 1.4L TURBO ECOTEC Downsized SIDI Turbo Boosting HCCI -...

  12. Advanced Fuel Cycle Initiative

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Working with INL Community Outreach Visitor Information Calendar of Events ATR National Scientific User Facility Center for Advanced Energy Studies Light Water Reactor...

  13. Advanced Fuel Cycle Program

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Working with INL Community Outreach Visitor Information Calendar of Events ATR National Scientific User Facility Center for Advanced Energy Studies Light Water Reactor...

  14. Advances in Physical Chemistry

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hindawi Publishing Corporation Advances in Physical Chemistry Volume 2011, Article ID 907129, 18 pages doi:10.11552011907129 Review Article Contrast and Synergy between...

  15. Plants & Animals

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Los Alamos, NM 87545 (505) 667-0216 Email We sample many plants and animals, including wild and domestic crops, game animals, fish, and food products from animals, as well as...

  16. Advanced Demand Responsive Lighting

    E-Print Network [OSTI]

    Advanced Demand Responsive Lighting Host: Francis Rubinstein Demand Response Research Center demand responsive lighting systems ­ Importance of dimming ­ New wireless controls technologies · Advanced Demand Responsive Lighting (commenced March 2007) #12;Objectives · Provide up-to-date information

  17. Kansas Advanced Semiconductor Project

    SciTech Connect (OSTI)

    Baringer, P.; Bean, A.; Bolton, T.; Horton-Smith, G.; Maravin, Y.; Ratra, B.; Stanton, N.; von Toerne, E.; Wilson, G.

    2007-09-21T23:59:59.000Z

    KASP (Kansas Advanced Semiconductor Project) completed the new Layer 0 upgrade for D0, assumed key electronics projects for the US CMS project, finished important new physics measurements with the D0 experiment at Fermilab, made substantial contributions to detector studies for the proposed e+e- international linear collider (ILC), and advanced key initiatives in non-accelerator-based neutrino physics.

  18. Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands. Correspondence should be addressed to A

    E-Print Network [OSTI]

    Cai, Long

    and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht

  19. BOILER MATERIALS FOR ULTRASUPERCRITICAL COAL POWER PLANTS

    SciTech Connect (OSTI)

    R. Viswanathan; K. Coleman; R.W. Swindeman; J. Sarver; J. Blough; W. Mohn; M. Borden; S. Goodstine; I. Perrin

    2003-10-20T23:59:59.000Z

    The principal objective of this project is to develop materials technology for use in ultrasupercritical (USC) plant boilers capable of operating with 760 C (1400 F), 35 MPa (5000 psi) steam. This project has established a government/industry consortium to undertake a five-year effort to evaluate and develop of advanced materials that allow the use of advanced steam cycles in coal-based power plants. These advanced cycles, with steam temperatures up to 760 C, will increase the efficiency of coal-fired boilers from an average of 35% efficiency (current domestic fleet) to 47% (HHV). This efficiency increase will enable coal-fired power plants to generate electricity at competitive rates (irrespective of fuel costs) while reducing CO{sub 2} and other fuel-related emissions by as much as 29%. Success in achieving these objectives will support a number of broader goals. First, from a national prospective, the program will identify advanced materials that will make it possible to maintain a cost-competitive, environmentally acceptable coal-based electric generation option. High sulfur coals will specifically benefit in this respect by having these advanced materials evaluated in high-sulfur coal firing conditions and from the significant reductions in waste generation inherent in the increased operational efficiency. Second, from a national prospective, the results of this program will enable domestic boiler manufacturers to successfully compete in world markets for building high-efficiency coal-fired power plants.

  20. Design of a rapid, continuous, small-scale device for creating dry powders from concentrated suspensions containing active pharmaceutical ingredients

    E-Print Network [OSTI]

    Correll, Eric Owen

    2011-01-01T23:59:59.000Z

    Current methods of producing pharmaceutical compounds are large batch processes. The minimum time-to-patient for drug manufacturing is approximately 100 days. Using a continuous manufacturing process, the time-to-patient ...

  1. Impact of the Massachusetts Pharmaceutical and Medical Device Manufacturer Code of Conduct on medical device physician-industry collaboration

    E-Print Network [OSTI]

    Wolf, Daniel W. (Daniel William)

    2010-01-01T23:59:59.000Z

    The Massachusetts Pharmaceutical and Medical Device Manufacturer Code of Conduct (PCOC) or 105 CMR 970.000 was enacted by the Massachusetts state legislature and adopted by the Department of Public Health (DPH) in July ...

  2. Frequency domain photon migration measurements: a method to size powders and detect active pharmaceutical ingredients in blending operations

    E-Print Network [OSTI]

    Torrance, Sharnay Etasha

    2004-01-01T23:59:59.000Z

    means for process validation in the manufacture of solid pharmaceutics through its ability to characterize powder ingredients by particle size and ingredient composition. In this work, FDPM analysis techniques were utilized to extract particle size...

  3. Mapping complexity sources in nuclear power plant domains

    E-Print Network [OSTI]

    Sasangohar, Farzan

    Understanding the sources of complexity in advanced Nuclear Power Plant (NPP) control rooms and their effects on human reliability is critical for ensuring safe performance of both operators and the entire system. New ...

  4. ICI's Approach to Total Energy Savings on Ethylene Plants

    E-Print Network [OSTI]

    Hindmarsh, E.; Boland, D.

    Recent technological developments have led to the creation of the rigorous simulation models for ethylene plants which can be run in concert with advanced, thermodynamic “pinch” procedures. This new approach enables operators to determine...

  5. ADVANCED TURBINE SYSTEM CONCEPTUAL DESIGN AND PRODUCT DEVELOPMENT - Final Report

    SciTech Connect (OSTI)

    Albrecht H. Mayer

    2000-07-15T23:59:59.000Z

    Asea Brown Boveri (ABB) has completed its technology based program. The results developed under Work Breakdown Structure (WBS) 8, concentrated on technology development and demonstration have been partially implemented in newer turbine designs. A significant improvement in heat rate and power output has been demonstrated. ABB will use the knowledge gained to further improve the efficiency of its Advanced Cycle System, which has been developed and introduced into the marked out side ABB's Advanced Turbine System (ATS) activities. The technology will lead to a power plant design that meets the ATS performance goals of over 60% plant efficiency, decreased electricity costs to consumers and lowest emissions.

  6. Welcome DigiTop--USDA's Digital Desktop Library Sign in | Register Journals Home APSnet IS-MPMInet My Profile Help Subscribe Search Advanced Search

    E-Print Network [OSTI]

    -MPMInet My Profile Help Subscribe Search Advanced Search ISSN: 0191-2917 SEARCH Enter Keywords Phytopathology Plant Disease MPMI Advanced Search Inside the Journal BACK ISSUES (Issues before 1997) View Most

  7. Comparative pathophysiology, toxicology, and human cancer risk assessment of pharmaceutical-induced hibernoma

    SciTech Connect (OSTI)

    Radi, Zaher, E-mail: zaher.radi@pfizer.com [Pfizer Worldwide Research and Development, Drug Safety R and D, 1 Burtt Rd., Andover, MA 01810 (United States); Bartholomew, Phillip, E-mail: phillip.m.bartholomew@pfizer.com [Pfizer Worldwide Research and Development, Drug Safety R and D, Eastern Point Road, Groton, CT 06340 (United States); Elwell, Michael, E-mail: michael.elwell@covance.com [Covance Laboratories, Chantilly, VA 20151 (United States); Vogel, W. Mark, E-mail: w.mark.vogel@pfizer.com [Pfizer Worldwide Research and Development, Drug Safety R and D, 1 Burtt Rd., Andover, MA 01810 (United States)

    2013-12-15T23:59:59.000Z

    In humans, hibernoma is a very rare, benign neoplasm of brown adipose tissue (BAT) that typically occurs at subcutaneous locations and is successfully treated by surgical excision. No single cause has been accepted to explain these very rare human tumors. In contrast, spontaneous hibernoma in rats is rare, often malignant, usually occurs in the thoracic or abdominal cavity, and metastases are common. In recent years, there has been an increased incidence of spontaneous hibernomas in rat carcinogenicity studies, but overall the occurrence remains relatively low and highly variable across studies. There have only been four reported examples of pharmaceutical-induced hibernoma in rat carcinogenicity studies. These include phentolamine, an alpha-adrenergic antagonist; varenicline, a nicotine partial agonist; tofacitinib, a Janus kinase (JAK) inhibitor; and hydromorphone, an opiod analgesic. Potential non-genotoxic mechanisms that may contribute to the pathogenesis of BAT activation/proliferation and/or subsequent hibernoma development in rats include: (1) physiological stimuli, (2) sympathetic stimulation, (3) peroxisome proliferator-activated receptor (PPAR) agonism, and/or (4) interference or inhibition of JAK/Signal Transducer and Activator of Transcription (JAK/STAT) signaling. The evaluation of an apparent increase of hibernoma in rats from 2-year carcinogenicity studies of novel pharmaceutical therapeutics and its relevance to human safety risk assessment is complex. One should consider: the genotoxicity of the test article, dose/exposure and safety margins, and pathophysiologic and morphologic differences and similarities of hibernoma between rats and humans. Hibernomas observed to date in carcinogenicity studies of pharmaceutical agents do not appear to be relevant for human risk at therapeutic dosages. - Highlights: • Highly variable incidence of spontaneous hibernoma in carcinogenicity studies • Recent increase in the spontaneous incidence of hibernomas in Sprague–Dawley rats • Pharmaceutical-related hibernoma has been observed in rats, but not in humans. • Pathophysiologic and morphologic differences of hibernoma between rats and 7 humans. • Hibernomas are unlikely to be relevant to human risk assessment.

  8. Analytical Validation of Accelerator Mass Spectrometry for Pharmaceutical Development: the Measurement of Carbon-14 Isotope Ratio.

    SciTech Connect (OSTI)

    Keck, B D; Ognibene, T; Vogel, J S

    2010-02-05T23:59:59.000Z

    Accelerator mass spectrometry (AMS) is an isotope based measurement technology that utilizes carbon-14 labeled compounds in the pharmaceutical development process to measure compounds at very low concentrations, empowers microdosing as an investigational tool, and extends the utility of {sup 14}C labeled compounds to dramatically lower levels. It is a form of isotope ratio mass spectrometry that can provide either measurements of total compound equivalents or, when coupled to separation technology such as chromatography, quantitation of specific compounds. The properties of AMS as a measurement technique are investigated here, and the parameters of method validation are shown. AMS, independent of any separation technique to which it may be coupled, is shown to be accurate, linear, precise, and robust. As the sensitivity and universality of AMS is constantly being explored and expanded, this work underpins many areas of pharmaceutical development including drug metabolism as well as absorption, distribution and excretion of pharmaceutical compounds as a fundamental step in drug development. The validation parameters for pharmaceutical analyses were examined for the accelerator mass spectrometry measurement of {sup 14}C/C ratio, independent of chemical separation procedures. The isotope ratio measurement was specific (owing to the {sup 14}C label), stable across samples storage conditions for at least one year, linear over 4 orders of magnitude with an analytical range from one tenth Modern to at least 2000 Modern (instrument specific). Further, accuracy was excellent between 1 and 3 percent while precision expressed as coefficient of variation is between 1 and 6% determined primarily by radiocarbon content and the time spent analyzing a sample. Sensitivity, expressed as LOD and LLOQ was 1 and 10 attomoles of carbon-14 (which can be expressed as compound equivalents) and for a typical small molecule labeled at 10% incorporated with {sup 14}C corresponds to 30 fg equivalents. AMS provides an sensitive, accurate and precise method of measuring drug compounds in biological matrices.

  9. The Clinical Development of Molecularly Targeted Agents in Combination With Radiation Therapy: A Pharmaceutical Perspective

    SciTech Connect (OSTI)

    Ataman, Ozlem U., E-mail: ouataman@hotmail.com [Global Medicines Development, AstraZeneca, Alderley Park, Macclesfield, Cheshire (United Kingdom); Sambrook, Sally J. [Global Medicines Development, AstraZeneca, Alderley Park, Macclesfield, Cheshire (United Kingdom)] [Global Medicines Development, AstraZeneca, Alderley Park, Macclesfield, Cheshire (United Kingdom); Wilks, Chris [Innovative Medicines, AstraZeneca, Alderley Park, Macclesfield, Cheshire (United Kingdom)] [Innovative Medicines, AstraZeneca, Alderley Park, Macclesfield, Cheshire (United Kingdom); Lloyd, Andrew [Global Medicines Development, AstraZeneca, Alderley Park, Macclesfield, Cheshire (United Kingdom)] [Global Medicines Development, AstraZeneca, Alderley Park, Macclesfield, Cheshire (United Kingdom); Taylor, Amanda E. [Yellow Delaney Communications Ltd, Wilmslow, Cheshire (United Kingdom)] [Yellow Delaney Communications Ltd, Wilmslow, Cheshire (United Kingdom); Wedge, Stephen R. [Innovative Medicines, AstraZeneca, Alderley Park, Macclesfield, Cheshire (United Kingdom)] [Innovative Medicines, AstraZeneca, Alderley Park, Macclesfield, Cheshire (United Kingdom)

    2012-11-15T23:59:59.000Z

    Summary: This paper explores historical and current roles of pharmaceutical industry sponsorship of clinical trials testing radiation therapy combinations with molecularly targeted agents and attempts to identify potential solutions to expediting further combination studies. An analysis of clinical trials involving a combination of radiation therapy and novel cancer therapies was performed. Ongoing and completed trials were identified by searching the (clinicaltrials.gov) Web site, in the first instance, with published trials of drugs of interest identified through American Society of Clinical Oncology, European CanCer Organisation/European Society for Medical Oncology, American Society for Radiation Oncology/European Society for Therapeutic Radiology and Oncology, and PubMed databases and then cross-correlated with (clinicaltrials.gov) protocols. We examined combination trials involving radiation therapy with novel agents and determined their distribution by tumor type, predominant molecular mechanisms examined in combination to date, timing of initiation of trials relative to a novel agent's primary development, and source of sponsorship of such trials. A total of 564 studies of targeted agents in combination with radiation therapy were identified with or without concomitant chemotherapy. Most studies were in phase I/II development, with only 36 trials in phase III. The tumor site most frequently studied was head and neck (26%), followed by non-small cell lung cancer. Pharmaceutical companies were the sponsors of 33% of studies overall and provided support for only 16% of phase III studies. In terms of pharmaceutical sponsorship, Genentech was the most active sponsor of radiation therapy combinations (22%), followed by AstraZeneca (14%). Most radiation therapy combination trials do not appear to be initiated until after drug approval. In phase III studies, the most common (58%) primary endpoint was overall survival. Collectively, this analysis suggests that such trials are not given priority by pharmaceutical companies. The potential reasons for this and some challenges and possible solutions are discussed.

  10. Genomic Aspects of Research Involving Polyploid Plants

    SciTech Connect (OSTI)

    Yang, Xiaohan [ORNL; Ye, Chuyu [ORNL; Tschaplinski, Timothy J [ORNL; Wullschleger, Stan D [ORNL; Tuskan, Gerald A [ORNL

    2011-01-01T23:59:59.000Z

    Almost all extant plant species have spontaneously doubled their genomes at least once in their evolutionary histories, resulting in polyploidy which provided a rich genomic resource for evolutionary processes. Moreover, superior polyploid clones have been created during the process of crop domestication. Polyploid plants generated by evolutionary processes and/or crop domestication have been the intentional or serendipitous focus of research dealing with the dynamics and consequences of genome evolution. One of the new trends in genomics research is to create synthetic polyploid plants which provide materials for studying the initial genomic changes/responses immediately after polyploid formation. Polyploid plants are also used in functional genomics research to study gene expression in a complex genomic background. In this review, we summarize the recent progress in genomics research involving ancient, young, and synthetic polyploid plants, with a focus on genome size evolution, genomics diversity, genomic rearrangement, genetic and epigenetic changes in duplicated genes, gene discovery, and comparative genomics. Implications on plant sciences including evolution, functional genomics, and plant breeding are presented. It is anticipated that polyploids will be a regular subject of genomics research in the foreseeable future as the rapid advances in DNA sequencing technology create unprecedented opportunities for discovering and monitoring genomic and transcriptomic changes in polyploid plants. The fast accumulation of knowledge on polyploid formation, maintenance, and divergence at whole-genome and subgenome levels will not only help plant biologists understand how plants have evolved and diversified, but also assist plant breeders in designing new strategies for crop improvement.

  11. Draft Advanced Nuclear Energy Projects Solicitation | Department...

    Broader source: Energy.gov (indexed) [DOE]

    Draft Advanced Nuclear Energy Projects Solicitation Draft Advanced Nuclear Energy Projects Solicitation INFORMATIONAL MATERIALS DRAFT ADVANCED NUCLEAR ENERGY PROJECTS SOLICITATION...

  12. Fact Sheet: Energy Storage Technology Advancement Partnership...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Technology Advancement Partnership (October 2012) Fact Sheet: Energy Storage Technology Advancement Partnership (October 2012) The Energy Storage Technology Advancement Partnership...

  13. Third international congress of plant molecular biology: Molecular biology of plant growth and development

    SciTech Connect (OSTI)

    Hallick, R.B. [ed.

    1995-02-01T23:59:59.000Z

    The Congress was held October 6-11, 1991 in Tucson with approximately 3000 scientists attending and over 300 oral presentations and 1800 posters. Plant molecular biology is one of the most rapidly developing areas of the biological sciences. Recent advances in the ability to isolate genes, to study their expression, and to create transgenic plants have had a major impact on our understanding of the many fundamental plant processes. In addition, new approaches have been created to improve plants for agricultural purposes. This is a book of presentation and posters from the conference.

  14. Search Asia Advanced Search

    E-Print Network [OSTI]

    Asia Times Search Asia Times Advanced Search Southeast Asia Malaysia tackles illegal logging:52:14 AM Search #12;Asia Times illegal logging," he said, adding that nine Malaysians had been arrested

  15. Search Asia Advanced Search

    E-Print Network [OSTI]

    Asia Times Search Asia Times Advanced Search Southeast Asia Indonesia looks to curb log smuggling.html (1 of 2)9/4/2007 12:59:34 PM Search #12;Asia Times No material from Asia Times Online may

  16. Advanced Review Geometry optimization

    E-Print Network [OSTI]

    Schlegel, H. Bernhard

    Advanced Review Geometry optimization H. Bernhard Schlegel Geometry optimization is an important part of most quantum chemical calcu- lations. This article surveys methods for optimizing equilibrium geometries, lo- cating transition structures, and following reaction paths. The emphasis is on optimizations

  17. Advanced Materials | More Science | ORNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Advanced Materials SHARE Advanced Materials ORNL has the nation's most comprehensive materials research program and is a world leader in research that supports the development of...

  18. Renewable Chemicals and Advanced Biofuels

    Broader source: Energy.gov [DOE]

    Afternoon Plenary Session: Current Trends in the Advanced Bioindustry Advanced Biofuels & Policy—Brett Lund, Executive Vice President, General Counsel and Secretary, Gevo Inc.

  19. URI inAdvance Online Newsletter July 23, 2009

    E-Print Network [OSTI]

    Rhode Island, University of

    for students interested in the pharmaceutical, biomedical, consumer product, and health care industries, product marketing, sales, testing, and administrative positions within the pharmaceutical industry" by the organization in spring 2008. More... New 4-year pharmaceutical science program to be offered A new four

  20. Systems Analyses of Advanced Brayton Cycles

    SciTech Connect (OSTI)

    A.D. Rao; D.J. Francuz; J.D. Maclay; J. Brouwer; A. Verma; M. Li; G.S. Samuelsen

    2008-09-30T23:59:59.000Z

    The main objective is to identify and assess advanced improvements to the Brayton Cycle (such as but not limited to firing temperature, pressure ratio, combustion techniques, intercooling, fuel or combustion air augmentation, enhanced blade cooling schemes) that will lead to significant performance improvements in coal based power systems. This assessment is conducted in the context of conceptual design studies (systems studies) that advance state-of-art Brayton cycles and result in coal based efficiencies equivalent to 65% + on natural gas basis (LHV), or approximately an 8% reduction in heat rate of an IGCC plant utilizing the H class steam cooled gas turbine. H class gas turbines are commercially offered by General Electric and Mitsubishi for natural gas based combined cycle applications with 60% efficiency (LHV) and it is expected that such machine will be offered for syngas applications within the next 10 years. The studies are being sufficiently detailed so that third parties will be able to validate portions or all of the studies. The designs and system studies are based on plants for near zero emissions (including CO{sub 2}). Also included in this program is the performance evaluation of other advanced technologies such as advanced compression concepts and the fuel cell based combined cycle. The objective of the fuel cell based combined cycle task is to identify the desired performance characteristics and design basis for a gas turbine that will be integrated with an SOFC in Integrated Gasification Fuel Cell (IGFC) applications. The goal is the conceptualization of near zero emission (including CO{sub 2} capture) integrated gasification power plants producing electricity as the principle product. The capability of such plants to coproduce H{sub 2} is qualitatively addressed. Since a total systems solution is critical to establishing a plant configuration worthy of a comprehensive market interest, a baseline IGCC plant scheme is developed and used to study how alternative process schemes and power cycles might be used and integrated to achieve higher systems efficiency. To achieve these design results, the total systems approach is taken requiring creative integration of the various process units within the plant. Advanced gas turbine based cycles for Integrated gasification Combined cycle (IGCC) applications are identified by a screening analysis and the more promising cycles recommended for detailed systems analysis. In the case of the IGFC task, the main objective is met by developing a steady-state simulation of the entire plant and then using dynamic simulations of the hybrid Solid Oxide Fuel Cell (SOFC)/Gas Turbine sub-system to investigate the turbo-machinery performance. From these investigations the desired performance characteristics and a basis for design of turbo-machinery for use in a fuel cell gas turbine power block is developed.

  1. Synthesis of three advanced biofuels from ionic liquid-pretreated switchgrass using engineered Escherichia coli

    E-Print Network [OSTI]

    Bokinsky, Gregory

    One approach to reducing the costs of advanced biofuel production from cellulosic biomass is to engineer a single microorganism to both digest plant biomass and produce hydrocarbons that have the properties of petrochemical ...

  2. E-Print Network 3.0 - advanced breeding lines Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    breeding lines Page: << < 1 2 3 4 5 > >> 1 TEXAS A&M PLANT BREEDING Video by Dr. Wayne Smith, click to play Summary: croprelease.html). Over 30 students are seeking advanced...

  3. E-Print Network 3.0 - advanced industrial concepts Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SECA fuel cells available for FutureGen 2020 MW-Scale SECA fuel cells for Advanced Coal Power Plants... 2010 400kW Modules -Residential, Commercial, Industrial CHP...

  4. Energy Efficiency Improvement and Cost Saving Opportunities for the Pharmaceutical Industry. An ENERGY STAR Guide for Energy and Plant Managers

    E-Print Network [OSTI]

    Galitsky, Christina

    2008-01-01T23:59:59.000Z

    a predictive and preventive maintenance program. The Motorand could save considerable energy. Preventive maintenance.A general preventive maintenance (PM) program

  5. Energy Efficiency Improvement and Cost Saving Opportunities for the Pharmaceutical Industry. An ENERGY STAR Guide for Energy and Plant Managers

    E-Print Network [OSTI]

    Galitsky, Christina

    2008-01-01T23:59:59.000Z

    Oversized and Underloaded Electric Motor. Office of EnergyOptimization Electric Motor System at a Corporate CampusUnited States Industrial Electric Motor Systems Market

  6. Energy Efficiency Improvement and Cost Saving Opportunities for the Pharmaceutical Industry. An ENERGY STAR Guide for Energy and Plant Managers

    E-Print Network [OSTI]

    Galitsky, Christina

    2008-01-01T23:59:59.000Z

    NEMA Premium ® Efficiency Electric Motor specification wasUnderloaded Electric Motor. Office of Energy Efficiency andElectric Apparatus Service Association (EASA) (2003). The Effect of Repair/Rewinding on Motor Efficiency.

  7. Energy Efficiency Improvement and Cost Saving Opportunities for the Pharmaceutical Industry. An ENERGY STAR Guide for Energy and Plant Managers

    E-Print Network [OSTI]

    Galitsky, Christina

    2008-01-01T23:59:59.000Z

    perpetuate less energy efficient designs. When a companytips for the energy efficient design of new labs andEnergy Guide. Energy efficient system design. The greatest

  8. Energy Efficiency Improvement and Cost Saving Opportunities for the Pharmaceutical Industry. An ENERGY STAR Guide for Energy and Plant Managers

    E-Print Network [OSTI]

    Galitsky, Christina

    2008-01-01T23:59:59.000Z

    2002a, 2002b). The power-to- heat ratio of a steam turbine-of electricity. The power-to-heat ratio of a gas turbine-co-generation, combined heat & power and renewable energy

  9. Energy Efficiency Improvement and Cost Saving Opportunities for the Pharmaceutical Industry. An ENERGY STAR Guide for Energy and Plant Managers

    E-Print Network [OSTI]

    Galitsky, Christina

    2008-01-01T23:59:59.000Z

    2005). Guidelines for Energy Management. Washington, D.C.Caffal, C. (1995). Energy Management in Industry. Centre forfor improving your energy management practices. Resources

  10. Energy Efficiency Improvement and Cost Saving Opportunities for the Pharmaceutical Industry. An ENERGY STAR Guide for Energy and Plant Managers

    E-Print Network [OSTI]

    Galitsky, Christina

    2008-01-01T23:59:59.000Z

    feet per minute Combined heat and power Canadian Industrythe use of combined heat and power (CHP) systems may be ableCogeneration Combined heat and power Power recovery turbines

  11. Energy Efficiency Improvement and Cost Saving Opportunities for the Pharmaceutical Industry. An ENERGY STAR Guide for Energy and Plant Managers

    E-Print Network [OSTI]

    Galitsky, Christina

    2008-01-01T23:59:59.000Z

    costs, and increased energy awareness among employees (Wyethimprove the awareness of personnel with regard to energy useawareness Build capacity Not addressed No promotion of energy

  12. Energy Efficiency Improvement and Cost Saving Opportunities for the Pharmaceutical Industry. An ENERGY STAR Guide for Energy and Plant Managers

    E-Print Network [OSTI]

    Galitsky, Christina

    2008-01-01T23:59:59.000Z

    refrigeration systems lead to high compressor energy consumptionrefrigeration systems can help energy managers and facilities engineers track energy consumption,

  13. Energy Efficiency Improvement and Cost Saving Opportunities for the Pharmaceutical Industry. An ENERGY STAR Guide for Energy and Plant Managers

    E-Print Network [OSTI]

    Galitsky, Christina

    2008-01-01T23:59:59.000Z

    for its cooling tower water. Solar air heating. Solar airSolar air heating Building insulation Restriction of sash openings Variable-air-volume hoods Improved filtration quality and efficiency Cooling towers

  14. Energy Efficiency Improvement and Cost Saving Opportunities for the Pharmaceutical Industry. An ENERGY STAR Guide for Energy and Plant Managers

    E-Print Network [OSTI]

    Galitsky, Christina

    2008-01-01T23:59:59.000Z

    O&M Best Practices for Energy-Efficient Buildings. PreparedGenentech, Vacaville: New Energy Efficient Site. Oakland,200,000 per Year with Energy-Efficient Motors. New York, New

  15. Energy Efficiency Improvement and Cost Saving Opportunities for the Pharmaceutical Industry. An ENERGY STAR Guide for Energy and Plant Managers

    E-Print Network [OSTI]

    Galitsky, Christina

    2008-01-01T23:59:59.000Z

    in a strategic energy management program are depicted inelements of a strategic energy management program. Energyfocused and strategic energy management program will help to

  16. Energy Efficiency Improvement and Cost Saving Opportunities for the Pharmaceutical Industry. An ENERGY STAR Guide for Energy and Plant Managers

    E-Print Network [OSTI]

    Galitsky, Christina

    2008-01-01T23:59:59.000Z

    and M. Kushler. (1997). Energy Efficiency in Automotive andSummer Study on Energy Efficiency in Industry. AmericanCalifornia Institute of Energy Efficiency ( CIEE). (2000b).

  17. Energy Efficiency Improvement and Cost Saving Opportunities for the Pharmaceutical Industry. An ENERGY STAR Guide for Energy and Plant Managers

    E-Print Network [OSTI]

    Galitsky, Christina

    2008-01-01T23:59:59.000Z

    Characterization: Gas Turbines. Arlington, VA. February.is higher than that of a gas turbine-based CHP system (74%,electrical efficiency of a gas turbine-based CHP system is

  18. Energy Efficiency Improvement and Cost Saving Opportunities for the Pharmaceutical Industry. An ENERGY STAR Guide for Energy and Plant Managers

    E-Print Network [OSTI]

    Galitsky, Christina

    2008-01-01T23:59:59.000Z

    the effects of low refrigerant charge. The cost of automatedby applying this measure. Monitoring of refrigerant charge.A low refrigerant charge can exist in many small direct

  19. Energy Efficiency Improvement and Cost Saving Opportunities for the Pharmaceutical Industry. An ENERGY STAR Guide for Energy and Plant Managers

    E-Print Network [OSTI]

    Galitsky, Christina

    2008-01-01T23:59:59.000Z

    use and organizational goals for energy efficiency. Stafforganizational commitment to continuous improvement of energy efficiency.efficiency project, limited finances, poor accountability for measures, or organizational

  20. E-Print Network 3.0 - advanced drug delivery Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    nano-biomaterials, pharmaceuticals and drug delivery. They are exploring numerous... the pharmaceutical industry--the PTRC has created a novel inhaled drug delivery method that...

  1. ADVANCED HIGH PERFORMANCE SOLID WALL BLANKET CONCEPTS

    SciTech Connect (OSTI)

    WONG, CPC; MALANG, S; NISHIO, S; RAFFRAY, R; SAGARA, S

    2002-04-01T23:59:59.000Z

    OAK A271 ADVANCED HIGH PERFORMANCE SOLID WALL BLANKET CONCEPTS. First wall and blanket (FW/blanket) design is a crucial element in the performance and acceptance of a fusion power plant. High temperature structural and breeding materials are needed for high thermal performance. A suitable combination of structural design with the selected materials is necessary for D-T fuel sufficiency. Whenever possible, low afterheat, low chemical reactivity and low activation materials are desired to achieve passive safety and minimize the amount of high-level waste. Of course the selected fusion FW/blanket design will have to match the operational scenarios of high performance plasma. The key characteristics of eight advanced high performance FW/blanket concepts are presented in this paper. Design configurations, performance characteristics, unique advantages and issues are summarized. All reviewed designs can satisfy most of the necessary design goals. For further development, in concert with the advancement in plasma control and scrape off layer physics, additional emphasis will be needed in the areas of first wall coating material selection, design of plasma stabilization coils, consideration of reactor startup and transient events. To validate the projected performance of the advanced FW/blanket concepts the critical element is the need for 14 MeV neutron irradiation facilities for the generation of necessary engineering design data and the prediction of FW/blanket components lifetime and availability.

  2. Advanced Turbine Systems scoping and feasibility studies

    SciTech Connect (OSTI)

    Bannister, R.L.; Little, D.A.; Wiant, B.C. (Westinghouse Electric Corp., Orlando, FL (United States)); Archer, D.H. (Carnegie-Mellon Univ., Pittsburgh, PA (United States))

    1993-01-01T23:59:59.000Z

    The objective of the Advanced Turbine Systems (ATS) study was to investigate innovative natural gas fired cycle developments to determine the feasibility of achieving 60% (LHV) efficiency within a 10-year time frame. The potential ATS was to be environmentally superior, cost competitive and adaptable to coal-derived fuels. The National Energy Strategy (NES) calls for a balanced program of greater energy efficiency, use of alternative fuels, and the environmentally responsible development of all US energy resources> Consistent with the NES, a Department of Energy (DOE) program has been created to develop Advanced Turbine Systems. The objective of this 10-year program is to develop natural gas fired base load power plants that will have cycle efficiencies greater than 60% (LHV), be environmentally superior to current technology, and also be cost competitive.

  3. Advanced Hydride Laboratory

    SciTech Connect (OSTI)

    Motyka, T.

    1989-01-01T23:59:59.000Z

    Metal hydrides have been used at the Savannah River Tritium Facilities since 1984. However, the most extensive application of metal hydride technology at the Savannah River Site is being planned for the Replacement Tritium Facility, a $140 million facility schedules for completion in 1990 and startup in 1991. In the new facility, metal hydride technology will be used to store, separate, isotopically purify, pump, and compress hydrogen isotopes. In support of the Replacement Tritium Facility, a $3.2 million, cold,'' process demonstration facility, the Advanced Hydride Laboratory began operation in November of 1987. The purpose of the Advanced Hydride Laboratory is to demonstrate the Replacement Tritium Facility's metal hydride technology by integrating the various unit operations into an overall process. This paper will describe the Advanced Hydride Laboratory, its role and its impact on the application of metal hydride technology to tritium handling.

  4. Advanced Hydride Laboratory

    SciTech Connect (OSTI)

    Motyka, T.

    1989-12-31T23:59:59.000Z

    Metal hydrides have been used at the Savannah River Tritium Facilities since 1984. However, the most extensive application of metal hydride technology at the Savannah River Site is being planned for the Replacement Tritium Facility, a $140 million facility schedules for completion in 1990 and startup in 1991. In the new facility, metal hydride technology will be used to store, separate, isotopically purify, pump, and compress hydrogen isotopes. In support of the Replacement Tritium Facility, a $3.2 million, ``cold,`` process demonstration facility, the Advanced Hydride Laboratory began operation in November of 1987. The purpose of the Advanced Hydride Laboratory is to demonstrate the Replacement Tritium Facility`s metal hydride technology by integrating the various unit operations into an overall process. This paper will describe the Advanced Hydride Laboratory, its role and its impact on the application of metal hydride technology to tritium handling.

  5. Advanced Vehicle Electrification and Transportation Sector Electrifica...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    More Documents & Publications Advanced Vehicle Electrification and Transportation Sector Electrification Advanced Vehicle Electrification & Transportation Sector...

  6. Metal fire implications for advanced reactors. Part 1, literature review.

    SciTech Connect (OSTI)

    Nowlen, Steven Patrick; Radel, Ross F.; Hewson, John C.; Olivier, Tara Jean; Blanchat, Thomas K.

    2007-10-01T23:59:59.000Z

    Public safety and acceptance is extremely important for the nuclear power renaissance to get started. The Advanced Burner Reactor and other potential designs utilize liquid sodium as a primary coolant which provides distinct challenges to the nuclear power industry. Fire is a dominant contributor to total nuclear plant risk events for current generation nuclear power plants. Utilizing past experience to develop suitable safety systems and procedures will minimize the chance of sodium leaks and the associated consequences in the next generation. An advanced understanding of metal fire behavior in regards to the new designs will benefit both science and industry. This report presents an extensive literature review that captures past experiences, new advanced reactor designs, and the current state-of-knowledge related to liquid sodium combustion behavior.

  7. Eva Kisdi, University of Helsinki, Finland. F1000 Ecology 17 Jul 2012 | New Finding, Technical Advance

    E-Print Network [OSTI]

    Hermisson, Joachim

    , Technical Advance 1. A simple fitness proxy for structured populations with continuous traits, with case of feedstocks for cellulosic biofuels Heather Youngs, Chris Somerville Plant-soil interactions in a changing and Sharing Relevant Sections Export More Options Search... Evaluated Articles Advanced Search Evaluated

  8. Advanced Optical Technologies

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinanInformation InInformationCenterResearch Highlights MediaFuelAbout Us >Portal AdvancedAdvanced

  9. Annual Report: Advanced Combustion (30 September 2012)

    SciTech Connect (OSTI)

    Hawk, Jeffrey [NETL] [NETL; Richards, George

    2012-09-30T23:59:59.000Z

    The Advanced Combustion Project addresses fundamental issues of fire-side and steam-side corrosion and materials performance in oxy-fuel combustion environments and provides an integrated approach into understanding the environmental and mechanical behavior such that environmental degradation can be ameliorated and long-term microstructural stability, and thus, mechanical performance can lead to longer lasting components and extended power plant life. The technical tasks of this effort are Oxy-combustion Environment Characterization, Alloy Modeling and Life Prediction, and Alloy Manufacturing and Process Development.

  10. "Nanotechnology Enabled Advanced Industrial Heat Transfer Fluids"

    SciTech Connect (OSTI)

    Dr. Ganesh Skandan; Dr. Amit Singhal; Mr. Kenneth Eberts; Mr. Damian Sobrevilla; Prof. Jerry Shan; Stephen Tse; Toby Rossmann

    2008-06-12T23:59:59.000Z

    ABSTRACT Nanotechnology Enabled Advanced industrial Heat Transfer Fluids” Improving the efficiency of Industrial Heat Exchangers offers a great opportunity to improve overall process efficiencies in diverse industries such as pharmaceutical, materials manufacturing and food processing. The higher efficiencies can come in part from improved heat transfer during both cooling and heating of the material being processed. Additionally, there is great interest in enhancing the performance and reducing the weight of heat exchangers used in automotives in order to increase fuel efficiency. The goal of the Phase I program was to develop nanoparticle containing heat transfer fluids (e.g., antifreeze, water, silicone and hydrocarbon-based oils) that are used in transportation and in the chemical industry for heating, cooling and recovering waste heat. Much work has been done to date at investigating the potential use of nanoparticle-enhanced thermal fluids to improve heat transfer in heat exchangers. In most cases the effect in a commercial heat transfer fluid has been marginal at best. In the Phase I work, we demonstrated that the thermal conductivity, and hence heat transfer, of a fluid containing nanoparticles can be dramatically increased when subjected to an external influence. The increase in thermal conductivity was significantly larger than what is predicted by commonly used thermal models for two-phase materials. Additionally, the surface of the nanoparticles was engineered so as to have a minimal influence on the viscosity of the fluid. As a result, a nanoparticle-laden fluid was successfully developed that can lead to enhanced heat transfer in both industrial and automotive heat exchangers

  11. Advanced fuel chemistry for advanced engines.

    SciTech Connect (OSTI)

    Taatjes, Craig A.; Jusinski, Leonard E.; Zador, Judit; Fernandes, Ravi X.; Miller, James A.

    2009-09-01T23:59:59.000Z

    Autoignition chemistry is central to predictive modeling of many advanced engine designs that combine high efficiency and low inherent pollutant emissions. This chemistry, and especially its pressure dependence, is poorly known for fuels derived from heavy petroleum and for biofuels, both of which are becoming increasingly prominent in the nation's fuel stream. We have investigated the pressure dependence of key ignition reactions for a series of molecules representative of non-traditional and alternative fuels. These investigations combined experimental characterization of hydroxyl radical production in well-controlled photolytically initiated oxidation and a hybrid modeling strategy that linked detailed quantum chemistry and computational kinetics of critical reactions with rate-equation models of the global chemical system. Comprehensive mechanisms for autoignition generally ignore the pressure dependence of branching fractions in the important alkyl + O{sub 2} reaction systems; however we have demonstrated that pressure-dependent 'formally direct' pathways persist at in-cylinder pressures.

  12. Solar-thermal hybridization of Advanced Zero Emissions Power Plants

    E-Print Network [OSTI]

    El Khaja, Ragheb Mohamad Fawaz

    2012-01-01T23:59:59.000Z

    Carbon Dioxide emissions from power production are believed to have significant contributions to the greenhouse effect and global warming. Alternative energy resources, such as solar radiation, may help abate emissions but ...

  13. Impact of Advanced Technologies on Fusion Power Plant Characteristics

    E-Print Network [OSTI]

    California at San Diego, University of

    Reliable Power Source: · Closed tritium fuel cycle on site; · Ability to operate at partial load conditions

  14. ADVANCED HYDROGEN TRANSPORT MEMBRANES FOR VISION 21 FOSSIL FUEL PLANTS

    SciTech Connect (OSTI)

    Shane E. Roark; Anthony F. Sammells; Richard A. Mackay; Lyrik Y. Pitzman; Thomas A. Zirbel; Thomas F. Barton; Sara L. Rolfe; U. (Balu) Balachandran; Richard N. Kleiner; James E. Stephan; Frank E. Anderson; George Farthing; Dan Rowley; Tim R. Armstrong; R.D. Carneim; P.F. Becher; C-H. Hsueh; Aaron L. Wagner; Jon P. Wagner

    2002-04-30T23:59:59.000Z

    Eltron Research Inc., and team members CoorsTek, McDermott Technology, inc., Sued Chemie, Argonne National Laboratory, and Oak Ridge National Laboratory are developing an environmentally benign, inexpensive, and efficient method for separating hydrogen from gas mixtures produced during industrial processes, such as coal gasification. This project was motivated by the National Energy Technology Laboratory (NETL) Vision 21 initiative which seeks to economically eliminate environmental concerns associated with the use of fossil fuels. This objective is being pursued using dense membranes based in part on Eltron-patented ceramic materials with a demonstrated ability for proton and electron conduction. The technical goals are being addressed by modifying single-phase and composite membrane composition and microstructure to maximize proton and electron conductivity without loss of material stability. Ultimately, these materials must enable hydrogen separation at practical rates under ambient and high-pressure conditions, without deactivation in the presence of feedstream components such as carbon dioxide, water, and sulfur.

  15. ADVANCED HYDROGEN TRANSPORT MEMBRANES FOR VISION 21 FOSSIL FUEL PLANTS

    SciTech Connect (OSTI)

    Shane E. Roark; Tony F. Sammells; Adam E. Calihman; Lyrik Y. Pitzman; Pamela M. Van Calcar; Richard A. Mackay; Tom F. Barton; Sara L. Rolfe; Richard N. Kleiner; James E. Stephan; Tim R. Armstrong; Mike J. Holmes; Aaron L. Wagner

    2001-04-30T23:59:59.000Z

    Eltron Research Inc., and team members, are developing an environmentally benign, inexpensive, and efficient method for separating hydrogen from gas mixtures produced during industrial processes, such as coal gasification. This project was motivated by the National Energy Technology Laboratory (NETL) Vision 21 initiative which seeks to economically eliminate environmental concerns associated with the use of fossil fuels. This objective is being pursued using dense membranes based in part on Eltron-patented ceramic materials with a demonstrated ability for proton and electron conduction. The technical goals are being addressed by modifying single-phase and composite membrane composition and microstructure to maximize proton and electron conductivity without loss of material stability. Ultimately, these materials must enable hydrogen separation at practical rates under ambient and high-pressure conditions, without deactivation in the presence of feedstream components such as carbon dioxide, water, and sulfur. During this quarter, it was demonstrated that increasing the transition metal loading in a model perovskite composition resulted in an increase in hydrogen flux. Improved flux corresponded to the emergence of additional phases in the ceramic membrane, and highest flux was achieved for a composite consisting of pseudo-cubic and rhombohedral perovskite phases. A 0.9-mm thick membrane of this material generated a hydrogen flux in excess of 0.1 mL/min/cm{sup 2}, which was approximately 35 times greater than analogs with lower transition metal levels. The dopant level and crystal structure also correlated with membrane density and coefficient of thermal expansion, but did not appear to affect grain size or shape. Additionally, preliminary ceramic-metal (cermet) composite membranes demonstrated a 10-fold increase in flux relative to analogous membranes composed of only the ceramic component. The hydrogen flux for these cermet samples corresponded to a conductivity of {approx} 10{sup -3} S/cm, which was consistent with the predicted proton conductivity of the ceramic phase. Increasing the sweep gas flow rate in test reactors was found to significantly increase hydrogen flux, as well as apparent material conductivity for all samples tested. Adding humidity to the feed gas stream produced a small increase in hydrogen flux. However, the catalyst on ceramic membrane surfaces did not affect flux, which suggested that the process was membrane-diffusion limited. Representative samples and fabrication processes were evaluated on the basis of manufacturing practicality. it was determined that optimum membrane densification occurs over a very narrow temperature range for the subject ceramics. Additionally, calcination temperatures currently employed result in powders that are difficult mill and screen. These issues must be addressed to improve large-scale fabricability.

  16. ADVANCED HYDROGEN TRANSPORT MEMBRANES FOR VISION 21 FOSSIL FUEL PLANTS

    SciTech Connect (OSTI)

    Shane E. Roark; Anthony F. Sammells; Richard A. Mackay; Lyrik Y. Pitzman; Thomas A. Zirbel; Thomas F. Barton; Sara L. Rolfe; U. (Balu) Balachandran; Richard N. Kleiner; James E. Stephan; Frank E. Anderson; George Farthing; Dan Rowley; Tim R. Armstrong; M.K. Ferber; Aaron L. Wagner; Jon P. Wagner

    2002-07-30T23:59:59.000Z

    Eltron Research Inc. and their team members are developing an environmentally benign, inexpensive, and efficient method for separating hydrogen from gas mixtures produced during industrial processes, such as coal gasification. This project was motivated by the National Energy Technology Laboratory (NETL) Vision 21 initiative which seeks to economically eliminate environmental concerns associated with the use of fossil fuels. This objective is being pursued using dense membranes based in part on Eltron-patented ceramic materials with a demonstrated ability for proton and electron conduction. The technical goals are being addressed by modifying single-phase and composite membrane composition and microstructure to maximize proton and electron conductivity without loss of material stability. Ultimately, these materials must enable hydrogen separation at practical rates under ambient and high-pressure conditions, without deactivation in the presence of feedstream components such as carbon dioxide, water, and sulfur. During this quarter, new cermet compositions were tested that demonstrated similar performance to previous materials. A 0.5-mm thick membrane achieved at H{sub 2} transport rate of 0.2 mL/min/cm{sup 2} at 950 C, which corresponded to an ambipolar conductivity of 3 x 10{sup -3} S/cm. Although these results were equivalent to those for other cermet compositions, this new composition might be useful if it demonstrates improved chemical or mechanical stability. Ceramic/ceramic composite membranes also were fabricated and tested; however, some reaction did occur between the proton- and electron-conducting phases, which likely compromised conductivity. This sample only achieved a H{sub 2} transport rate of {approx} 0.006 mL/min/cm{sup 2} and an ambipolar conductivity of {approx}4 x 10{sup -4} S/cm. Chemical stability tests were continued, and candidate ceramic membranes were found to react slightly with carbon monoxide under extreme testing conditions. A cermet compositions did not show any reaction with carbon monoxide, but a thick layer of carbon formed on the membrane surface. The most significant technical accomplishment this quarter was a new high-pressure seal composition. This material maintained a pressure differential across the membrane of {approx} 280 psi at 800 C, and is still in operation.

  17. ADVANCED HYDROGEN TRANSPORT MEMBRANES FOR VISION 21 FOSSIL FUEL PLANTS

    SciTech Connect (OSTI)

    Shane E. Roark; Tony F. Sammells; Richard A. Mackay; Lyrik Y. Pitzman; Alexandra Z. LaGuardia; Tom F. Barton; Sara L. Rolfe; Richard N. Kleiner; James E. Stephan; Mike J. Holmes; Aaron L. Wagner

    2001-10-30T23:59:59.000Z

    Eltron Research Inc., and team members CoorsTek, McDermott Technology, Inc., Sued Chemie, Argonne National Laboratory and Oak Ridge National Laboratory are developing an environmentally benign, inexpensive, and efficient method for separating hydrogen from gas mixtures produced during industrial processes, such as coal gasification. This project was motivated by the National Energy Technology Laboratory (NETL) Vision 21 initiative which seeks to economically eliminate environmental concerns associated with the use of fossil fuels. This objective is being pursued using dense membranes based in part on Eltron-patented ceramic materials with a demonstrated ability for proton and electron conduction. The technical goals are being addressed by modifying single-phase and composite membrane composition and microstructure to maximize proton and electron conductivity without loss of material stability. Ultimately, these materials must enable hydrogen separation at practical rates under ambient and high-pressure conditions, without deactivation in the presence of feedstream components such as carbon dioxide, water, and sulfur. During this quarter, mixed proton/electron conductivity and hydrogen transport was measured as a function of metal phase content for a range of ceramic/metal (cermet) compositions. It was found that optimum performance occurred at 44 wt.% metal content for all compositions tested. Although each cermet appeared to have a continuous metal phase, it is believed that hydrogen transport increased with increasing metal content partially due to beneficial surface catalyst characteristics resulting from the metal phase. Beyond 44 wt.% there was a reduction in hydrogen transport most likely due to dilution of the proton conducting ceramic phase. Hydrogen separation rates for 1-mm thick cermet membranes were in excess of 0.1 mL/min/cm{sup 2}, which corresponded to ambipolar conductivities between 1 x 10{sup -3} and 8 x 10{sup -3} S/cm. Similar results were obtained for multiphase ceramic membranes comprised of a proton-conducting perovskite and electron conducting metal oxide. These multi-phase ceramic membranes showed only a slight improvement in hydrogen transport upon addition of a metal phase. The highest hydrogen separation rates observed this quarter were for a cermet membrane containing a hydrogen transport metal. A 1-mm thick membrane of this material achieved a hydrogen separation rate of 0.3 mL/min/cm{sup 2} at only 700 C, which increased to 0.6 mL/min/cm{sup 2} at 950 C.

  18. Secretary Chu Visits Advanced Battery Plant in Michigan, Announces...

    Energy Savers [EERE]

    we'll have the capacity to manufacture enough batteries and components for 500,000 electric vehicles annually by 2015. To compete in the global economy, the United States...

  19. Distillation and Dehydro Reactors Advanced Process Conrol Freeport Texas PLant

    E-Print Network [OSTI]

    Eisele, D.

    2014-01-01T23:59:59.000Z

    Input Screen 6/2/2014 INTERNAL; CONFIDENTIAL 18 • External Targets such as desired dehydro reactor feed rates are inputs to the APC screen with dependent variables. • There are only six external targets. • The upper and lower limits are shown... – Results July and August 2013 6/2/2014 INTERNAL; CONFIDENTIAL 30 Cost of the Dehydro Reactors APC Project - $273,000 Initial Project Targets for the APC Project Feed Increase of 232 lb/hr. One Percent Decrease in Steam Usage Measured Results for the APC...

  20. ADVANCED HYDROGEN TRANSPORT MEMBRANES FOR VISION 21 FOSSIL FUEL PLANTS

    SciTech Connect (OSTI)

    Shane E. Roark; Anthony F. Sammells; Richard A. Mackay; Lyrik Y. Pitzman; Thomas A. Zirbel; Stewart R. Schesnack; Thomas F. Barton; Sara L. Rolfe; U. (Balu) Balachandran; Richard N. Kleiner; James E. Stephan; Frank E. Anderson; Aaron L. Wagner; Jon P. Wagner

    2003-01-30T23:59:59.000Z

    Eltron Research Inc., and team members CoorsTek, Sued Chemie, and Argonne National Laboratory are developing an environmentally benign, inexpensive, and efficient method for separating hydrogen from gas mixtures produced during industrial processes, such as coal gasification. This project was motivated by the National Energy Technology Laboratory (NETL) Vision 21 initiative which seeks to economically eliminate environmental concerns associated with the use of fossil fuels. This objective is being pursued using dense membranes based in part on Eltron-patented ceramic materials with a demonstrated ability for proton and electron conduction. The technical goals are being addressed by modifying composite membrane composition and microstructure to maximize hydrogen permeation without loss of material stability. Ultimately, these materials must enable hydrogen separation at practical rates under ambient and high-pressure conditions, without deactivation in the presence of feedstream components such as carbon dioxide, water, and sulfur. During this quarter, a composite metal membrane based on an inexpensive hydrogen permeable metal achieved permeation rates in excess of 25 mL/min/cm{sup 2}. Preliminary attempts to incorporate this metal into a cermet were successful, and a thick cermet membrane (0.83 mm) with 40 vol.% metal phase achieved a permeation rate of nearly 0.4 mL/min/cm{sup 2}. Increasing the metal phase content and decreasing membrane thickness should significantly increase permeation, while maintaining the benefits derived from cermets. Two-phase ceramic/ceramic composite membranes had low hydrogen permeability, likely due to interdiffusion of constituents between the phases. However, these materials did demonstrate high resistance to corrosion, and might be good candidates for other composite membranes. Temperature-programmed reduction measurements indicated that model cermet materials absorbed 2.5 times as much hydrogen than the pure ceramic analogs. This characteristic, in addition to higher electron conductivity, likely explains the relatively high permeation for these cermets. Incorporation of catalysts with ceramics and cermets increased hydrogen uptake by 800 to more than 900%. Finally, new high-pressure seals were developed for cermet membranes that maintained a pressure differential of 250 psi. This result indicated that the approach for high-pressure seal development could be adapted for a range of compositions. Other items discussed in this report include mechanical testing, new proton conducting ceramics, supported thin films, and alkane to olefin conversion.

  1. Advanced combustion technologies for gas turbine power plants

    SciTech Connect (OSTI)

    Vandsburger, U. [Virginia Polytechnic Inst. and State Univ., Blacksburg, VA (United States). Dept. of Mechanical Engineering; Roe, L.A. [Arkansas Univ., Fayetteville, AR (United States). Dept. of Mechanical Engineering; Desu, S.B. [Virginia Polytechnic Inst. and State Univ., Blacksburg, VA (United States). Dept. of Materials Science and Engineering

    1995-12-31T23:59:59.000Z

    Objectives are to develop actuators for enhancing the mixing between gas streams, increase combustion stability, and develop hgih-temperature materials for actuators and sensors in combustors. Turbulent kinetic energy maps of an excited jet with co-flow in a cavity with a partially closed exhaust end are given with and without a longitudinal or a transverse acoustic field. Dielectric constants and piezoelectric coefficients were determined for Sr{sub 2}(Nb{sub x}Ta{sub 1-x}){sub 2}O{sub 7} ceramics.

  2. Project Profile: Advanced Nitrate Salt Central Receiver Power Plant |

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarly Careerlumens_placard-green.epsEnergy1.pdfMarket |21,-CommitteeItems at6ACity HQdetailsLIFEDepartment

  3. Saft America Advanced Batteries Plant Celebrates Grand Opening in

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -the Mid-Infrared0 ResourceAwardsSafeguards and SecuritySafety forJacksonville |

  4. DOE Advances Innovative CCS Polygeneration Plant Through NEPA Process |

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarly Career Scientists'Montana. DOCUMENTS AVAILABLEReport 2009SiteMajor Maintenance atT A * S H I E

  5. MERCURY CONTROL WITH ADVANCED HYBRID PARTICULATE COLLECTOR

    SciTech Connect (OSTI)

    Ye Zhuang; Stanley J. Miller

    2005-05-01T23:59:59.000Z

    This project was awarded under U.S. Department of Energy (DOE) National Energy Technology Laboratory (NETL) Program Solicitation DE-PS26-00NT40769 and specifically addressed Technical Topical Area 4-Testing Novel and Less Mature Control Technologies on Actual Flue Gas at the Pilot Scale. The project team included the Energy & Environmental Research Center (EERC) as the main contractor; W.L. Gore & Associates, Inc., as a technical and financial partner; and the Big Stone Power Plant operated by Otter Tail Power Company, host for the field-testing portion of the research. Since 1995, DOE has supported development of a new concept in particulate control called the advanced hybrid particulate collector (AHPC). The AHPC has been licensed to W.L. Gore & Associates, Inc., and has been marketed as the Advanced Hybrid{trademark} filter by Gore. The Advanced Hybrid{trademark} filter combines the best features of electrostatic precipitators (ESPs) and baghouses in a unique configuration, providing major synergism between the two collection methods, both in the particulate collection step and in the transfer of dust to the hopper. The Advanced Hybrid{trademark} filter provides ultrahigh collection efficiency, overcoming the problem of excessive fine-particle emissions with conventional ESPs, and it solves the problem of reentrainment and re-collection of dust in conventional baghouses. The Advanced Hybrid{trademark} filter also appears to have unique advantages for mercury control over baghouses or ESPs as an excellent gas--solid contactor. The objective of the project was to demonstrate 90% total mercury control in the Advanced Hybrid{trademark} filter at a lower cost than current mercury control estimates. The approach included bench-scale batch tests, larger-scale pilot testing with real flue gas on a coal-fired combustion system, and field demonstration at the 2.5-MW (9000-acfm) scale at a utility power plant to prove scale-up and demonstrate longer-term mercury control. An additional task was included in this project to evaluate mercury oxidation upstream of a dry scrubber by using mercury oxidants. This project demonstrated at the pilot-scale level a technology that provides a cost-effective technique to control mercury and, at the same time, greatly enhances fine particulate collection efficiency. The technology can be used to retrofit systems currently employing inefficient ESP technology as well as for new construction, thereby providing a solution for improved fine particulate control combined with effective mercury control for a large segment of the U.S. utility industry as well as other industries.

  6. Bagdad Plant

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-Up fromDepartmentTie Ltd: Scope ChangeL-01-06Hot-Humid- EngineB2Bagdad Plant 585 Silicon

  7. Arnold Schwarzenegger ADVANCEMENT OF

    E-Print Network [OSTI]

    Arnold Schwarzenegger Governor ADVANCEMENT OF ELECTROCHROMIC WINDOWS Prepared For: California the time to provide insightful technical and market-related input into the direction of this R&D: Carl Mechoshade Systems, Inc. Grant Brohard Pacific Gas & Electric Company Charles Hayes SAGE Electrochromics, Inc

  8. Advanced fossil energy utilization

    SciTech Connect (OSTI)

    Shekhawat, D.; Berry, D.; Spivey, J.; Pennline, H.; Granite, E.

    2010-01-01T23:59:59.000Z

    This special issue of Fuel is a selection of papers presented at the symposium ‘Advanced Fossil Energy Utilization’ co-sponsored by the Fuels and Petrochemicals Division and Research and New Technology Committee in the 2009 American Institute of Chemical Engineers (AIChE) Spring National Meeting Tampa, FL, on April 26–30, 2009.

  9. Standard version Advanced version

    E-Print Network [OSTI]

    Hall, Julian

    Minimum octane 8.5 7 4.5 To produce these products, Margaret purchases crude oil at a price of £11 per version Margaret Oil - basic (2) Before crude can be used to produce products for sale, it must version Advanced version Margaret Oil - basic (3) Crude Distill Naphtha Gasoline Distilled 1 Jet fuel

  10. Advanced Test Reactor Tour

    SciTech Connect (OSTI)

    Miley, Don

    2011-01-01T23:59:59.000Z

    The Advanced Test Reactor at Idaho National Laboratory is the foremost nuclear materials test reactor in the world. This virtual tour describes the reactor, how experiments are conducted, and how spent nuclear fuel is handled and stored. For more information about INL research, visit http://www.facebook.com/idahonationallaboratory.

  11. Advanced Test Reactor Tour

    ScienceCinema (OSTI)

    Miley, Don

    2013-05-28T23:59:59.000Z

    The Advanced Test Reactor at Idaho National Laboratory is the foremost nuclear materials test reactor in the world. This virtual tour describes the reactor, how experiments are conducted, and how spent nuclear fuel is handled and stored. For more information about INL research, visit http://www.facebook.com/idahonationallaboratory.

  12. International for Advanced Studies

    E-Print Network [OSTI]

    Pfeifer, Holger

    and Technology at the University of Ulm ICAS-Affiliations The International Center for Advanced Studies in Health in medical technology and pharma- ceutical industry. The International Advisory Panel of ICAS consists, transfer of state-of-the-art clinical technologies, and utilization of methodologies appropriate

  13. Advanced Biotechnology and Medicine

    E-Print Network [OSTI]

    , Training and Technology Transfer 43 Lectures and Seminars 44 CABM Lecture Series 45 Annual Retreat 46 15th An Advanced Technology Center of The New Jersey Commission on Science and Technology Jointly Administered from CABM laboratories have appeared in high impact international journals including Development, Genes

  14. Advanced Biotechnology and Medicine

    E-Print Network [OSTI]

    Shatkin 41 Education, Training and Technology Transfer 43 Lectures and Seminars 44 CABM Lecture Series 45 An Advanced Technology Center of The New Jersey Commission on Science and Technology Jointly Administered for the improvement of human health. In 2002 peer-reviewed CABM studies were published in leading international

  15. Advanced Biotechnology and Medicine

    E-Print Network [OSTI]

    Vikas Nanda 63 Protein Crystallography Ann Stock 67 Education, Training and Technology Transfer 71 Report An Advanced Technology Center of the New Jersey Commission on Science and Technology Jointly, the CIPR will house the Rutgers-based Protein Data Bank (PDB), an international repository directed

  16. Project Sponsor: Department of EnergyADVANCED POWER & ENERGY www.apep.uci.edu

    E-Print Network [OSTI]

    Mease, Kenneth D.

    a given fuel source per unit of power produced is inversely proportional to the plant thermal efficiency emission and higher specific power output. Resulting thermal efficiency of the plant at 38% (coal HHV basisProject Sponsor: Department of EnergyADVANCED POWER & ENERGY PROGRAM www.apep.uci.edu RESULTS

  17. TECHNICAL ADVANCE The ethanol switch: a tool for tissue-specic gene induction

    E-Print Network [OSTI]

    Murray, J.A.H.

    TECHNICAL ADVANCE The ethanol switch: a tool for tissue-speci®c gene induction during plant is a powerful tool for the analysis of gene function during plant development. Here, we report ethanol inducible of an ethanol-regulated transcription factor, ALCR, is restricted to precise domains using speci®c promoters

  18. Compact Stellarator Power Plants Prospects, Technical Issue, and R&D Directions

    E-Print Network [OSTI]

    Najmabadi, Farrokh

    1 FT/P3-13 Compact Stellarator Power Plants ­ Prospects, Technical Issue, and R&D Directions F was to investigate whether stellarator power plants can be made to be similar in size to advanced tokamak variants features as a power plant because of the lack of a large driven external current: they are inherently

  19. Method for loading lipsomes with ionizable phosphorylated hydrophobic compounds, pharmaceutical preparations and a method for administering the preparations

    DOE Patents [OSTI]

    Mehlhorn, R.J.

    1998-10-27T23:59:59.000Z

    A method of entrapping ionizable compounds, preferably phosphorylated hydrophobic compounds, into liposomes having transmembrane gradients is disclosed. The procedures involve forming liposomes in an acidic medium or a basic medium, adding to the acidic medium a cationic compound or to the basic medium an anionic compound and then adding a base to the cationic-containing medium or an acid to the anionic-containing medium, thereby inducing the ionizable compound into the liposomes` internal aqueous phase. The compound-entrapped liposomes prepared in accordance with the disclosed methods may be used as pharmaceutical preparations. Methods of administering such pharmaceutical preparations are also disclosed. 2 figs.

  20. Method for loading lipsomes with ionizable phosphorylated hydrophobic compounds, pharmaceutical preparations and a method for administering the preparations

    DOE Patents [OSTI]

    Mehlhorn, Rolf Joachim (Richmond, CA)

    1998-10-27T23:59:59.000Z

    A method of entrapping ionizable compounds, preferably phosphorylated hydrophobic compounds, into liposomes having transmembrane gradients is disclosed. The procedures involve forming liposomes in an acidic medium or a basic medium, adding to the acidic medium a cationic compound or to the basic medium an anionic compound and then adding a base to the cationic-containing medium or an acid to the anionic-containing medium, thereby inducing the ionizable compound into the liposomes' internal aqueous phase. The compound-entrapped liposomes prepared in accordance with the disclosed methods may be used as pharmaceutical preparations. Methods of administering such pharmaceutical preparations are also disclosed.

  1. Advanced Manufacture of Reflectors

    SciTech Connect (OSTI)

    Angel, Roger [University of Arizona

    2014-12-17T23:59:59.000Z

    The main project objective has been to develop an advanced gravity sag method for molding large glass solar reflectors with either line or point focus, and with long or short focal length. The method involves taking standard sized squares of glass, 1.65 m x 1.65 m, and shaping them by gravity sag into precision steel molds. The method is designed for high volume manufacture when incorporated into a production line with separate pre-heating and cooling. The performance objectives for the self-supporting glass mirrors made by this project include mirror optical accuracy of 2 mrad root mean square (RMS), requiring surface slope errors <1 mrad rms, a target not met by current production of solar reflectors. Our objective also included development of new methods for rapidly shaping glass mirrors and coating them for higher reflectivity and soil resistance. Reflectivity of 95% for a glass mirror with anti-soil coating was targeted, compared to the present ~94% with no anti-soil coating. Our mirror cost objective is ~$20/m2 in 2020, a significant reduction compared to the present ~$35/m2 for solar trough mirrors produced for trough solar plants. During the first year a custom batch furnace was built to develop the method with high power radiative heating to simulate transfer of glass into a hot slumping zone in a production line. To preserve the original high polish of the float glass on both front and back surfaces, as required for a second surface mirror, the mold surface is machined to the required shape as grooves which intersect the glass at cusps, reducing the mold contact area to significantly less than 1%. The mold surface is gold-plated to reflect thermal radiation. Optical metrology of glass replicas made with the system has been carried out with a novel, custom-built test system. This test provides collimated, vertically-oriented parallel beams from a linear array of co-aligned lasers translated in a perpendicular direction across the reflector. Deviations of each reflected beam from the paraboloid focus give a direct measure of surface slope error. Key findings • A gravity sag method for large (2.5 m2) second surface glass solar reflectors has been developed and demonstrated to a uniquely high level of accuracy. Mirror surface slope accuracy of 0.65 mrad in one dimension, 0.85 mrad in 2 dimensions (point focus) has been demonstrated by commercial partner REhnu using this process. This accuracy exceeds by a factor of two current solar reflector accuracy. Our replicas meet the Sunshot accuracy objective of 2 mrad optical, which requires better than 1 mrad rms slope error. • Point-focus as well as line-focus mirrors have been demonstrated at 1.65 m x 1.65 m square – a unique capability. • The new process using simple molds is economical. The molds for the 1.65 m square reflectors are bent and machined steel plates on a counter-weighted flotation support. To minimize thermal coupling by radiative heat transfer, the mold surface is grooved and gilded. The molds are simple to manufacture, and have minimal thermal stresses and distortion in use. Lapping and bending techniques have been developed to obtain better than 1 mrad rms surface mold accuracy. Float glass is sagged into the molds by rapid radiative heating, using a custom high power (350 kW) furnace. The method of manufacture is well suited for small as well as large volume production, and as it requires little capital investment and no high technology, it could be used anywhere in the world to make solar concentrating reflectors. • A novel slope metrology method for full 1.65 aperture has been demonstrated, with 25 mm resolution across the face of the replicas. The method is null and therefore inherently accurate: it can easily be reproduced without high-tech equipment and does not need sophisticated calibration. We find by cross calibration with reference trough reflectors from RioGlass that our null-test laser system yields a measurement accuracy better than 0.4 mrad rms slope error. Our system is inexpensive and could have broad application for test

  2. Plant Operational Status - Pantex Plant

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinanInformation Desert Southwest RegionatSearch Welcome to theNews & Blog »Physics PhysicsWeek »Plant

  3. ImpactQM and Queen Mary Careers Office are proud to present a master class in OEA Career in the Pharmaceutical Industry by Dr Rob Pinnock,

    E-Print Network [OSTI]

    Wright, Francis

    in the Pharmaceutical Industry¹ by Dr Rob Pinnock, Director of Scientific Liaison at Merck, Sharp & Dohme. The talk the pharmaceutical industry Rob trained in Southampton (BSc & PhD) & spent seven years as a research fellow: impactqm@eecs.qmul.ac.uk . Dr Pinnock is going to talk for about 45 minutes about his career in industry

  4. Advanced turbine systems: Studies and conceptual design

    SciTech Connect (OSTI)

    van der Linden, S.; Gnaedig, G.; Kreitmeier, F.

    1993-11-01T23:59:59.000Z

    The ABB selection for the Advanced Turbine System (ATS) includes advanced developments especially in the hot gas path of the combustion turbine and new state-of-the-art units such as the steam turbine and the HRSG. The increase in efficiency by more than 10% multiplicative compared to current designs will be based on: (1) Turbine Inlet Temperature Increase; (2) New Cooling Techniques for Stationary and Rotating Parts; and New Materials. Present, projected component improvements that will be introduced with the above mentioned issues will yield improved CCSC turbine performance, which will drive the ATS selected gas-fired reference CC power plant to 6 % LHV or better. The decrease in emission levels requires a careful optimization of the cycle design, where cooling air consumption has to be minimized. All interfaces of the individual systems in the complete CC Plant need careful checks, especially to avoid unnecessary margins in the individual designs. This study is an important step pointing out the feasibility of the ATS program with realistic goals set by DOE, which, however, will present challenges for Phase II time schedule of 18 months. With the approach outlined in this study and close cooperation with DOE, ATS program success can be achieved to deliver low emissions and low cost of electricity by the year 2002. The ABB conceptual design and step approach will lead to early component demonstration which will help accelerate the overall program objectives.

  5. Herty Advanced Materials Development Center

    Broader source: Energy.gov [DOE]

    Session 1-B: Advancing Alternative Fuels for the Military and Aviation Sector Breakout Session 1: New Developments and Hot Topics Jill Stuckey, Acting Director, Herty Advanced Materials Development Center

  6. Search Advanced Search Home > News

    E-Print Network [OSTI]

    Rogers, John A.

    Search Advanced Search Home > News [-] Text [+] Email Print tweet 0 tweets RSS Feeds Newsletters with bodily tissues, "these approaches might have the potential to redefine design strategies for advanced

  7. Advanced Technology Vehicle Testing

    SciTech Connect (OSTI)

    James Francfort

    2004-06-01T23:59:59.000Z

    The goal of the U.S. Department of Energy's Advanced Vehicle Testing Activity (AVTA) is to increase the body of knowledge as well as the awareness and acceptance of electric drive and other advanced technology vehicles (ATV). The AVTA accomplishes this goal by testing ATVs on test tracks and dynamometers (Baseline Performance testing), as well as in real-world applications (Fleet and Accelerated Reliability testing and public demonstrations). This enables the AVTA to provide Federal and private fleet managers, as well as other potential ATV users, with accurate and unbiased information on vehicle performance and infrastructure needs so they can make informed decisions about acquiring and operating ATVs. The ATVs currently in testing include vehicles that burn gaseous hydrogen (H2) fuel and hydrogen/CNG (H/CNG) blended fuels in internal combustion engines (ICE), and hybrid electric (HEV), urban electric, and neighborhood electric vehicles. The AVTA is part of DOE's FreedomCAR and Vehicle Technologies Program.

  8. Advanced Separation Consortium

    SciTech Connect (OSTI)

    NONE

    2006-01-01T23:59:59.000Z

    The Center for Advanced Separation Technologies (CAST) was formed in 2001 under the sponsorship of the US Department of Energy to conduct fundamental research in advanced separation and to develop technologies that can be used to produce coal and minerals in an efficient and environmentally acceptable manner. The CAST consortium consists of seven universities - Virginia Tech, West Virginia University, University of Kentucky, Montana Tech, University of Utah, University of Nevada-Reno, and New Mexico Tech. The consortium brings together a broad range of expertise to solve problems facing the US coal industry and the mining sector in general. At present, a total of 60 research projects are under way. The article outlines some of these, on topics including innovative dewatering technologies, removal of mercury and other impurities, and modelling of the flotation process. 1 photo.

  9. Advanced Photon Source Upgrade Project

    ScienceCinema (OSTI)

    Mitchell, John; Gibson, Murray; Young, Linda; Joachimiak, Andrzej

    2013-04-19T23:59:59.000Z

    Upgrade to Advanced Photon Source announced by Department Of Energy. Read more: http://go.usa.gov/ivZ

  10. Advanced Polymer Processing Facility

    SciTech Connect (OSTI)

    Muenchausen, Ross E. [Los Alamos National Laboratory

    2012-07-25T23:59:59.000Z

    Some conclusions of this presentation are: (1) Radiation-assisted nanotechnology applications will continue to grow; (2) The APPF will provide a unique focus for radiolytic processing of nanomaterials in support of DOE-DP, other DOE and advanced manufacturing initiatives; (3) {gamma}, X-ray, e-beam and ion beam processing will increasingly be applied for 'green' manufacturing of nanomaterials and nanocomposites; and (4) Biomedical science and engineering may ultimately be the biggest application area for radiation-assisted nanotechnology development.

  11. ADVANCED CHEMISTRY BASINS MODEL

    SciTech Connect (OSTI)

    William Goddard III; Lawrence Cathles III; Mario Blanco; Paul Manhardt; Peter Meulbroek; Yongchun Tang

    2004-05-01T23:59:59.000Z

    The advanced Chemistry Basin Model project has been operative for 48 months. During this period, about half the project tasks are on projected schedule. On average the project is somewhat behind schedule (90%). Unanticipated issues are causing model integration to take longer then scheduled, delaying final debugging and manual development. It is anticipated that a short extension will be required to fulfill all contract obligations.

  12. Advanced Materials Manufacturing | ORNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth (AOD)ProductssondeadjustsondeadjustAbout the BuildingInnovation Portal Advanced Material

  13. Advanced Microturbine Systems

    SciTech Connect (OSTI)

    None

    2005-12-31T23:59:59.000Z

    Dept. of Energy (DOE) Cooperative Agreement DE-FC02-00-CH11061 was originally awarded to Honeywell International, Inc. â?? Honeywell Power Systems Inc. (HPSI) division located in Albuquerque, NM in October 2000 to conduct a program titled Advanced Microturbine Systems (AMS). The DOE Advanced Microturbines Systems Program was originally proposed as a five-year program to design and develop a high efficiency, low emissions, durable microturbine system. The period of performance was to be October 2000 through September 2005. Program efforts were underway, when one year into the program Honeywell sold the intellectual property of Honeywell Power Systems Inc. and HPSI ceased business operations. Honeywell made an internal decision to restructure the existing program due to the HPSI shutdown and submitted a formal request to DOE on September 24, 2001 to transfer the Cooperative Agreement to Honeywell Engines, Systems and Services (HES&S) in Phoenix, AZ in order to continue to offer support for DOE's Advanced Microturbine Program. Work continued on the descoped program under Cooperative Agreement No. DE-FC26-00-CH11061 and has been completed.

  14. Advanced Energy Design Guides | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Advanced Energy Design Guides Advanced Energy Design Guides EERE Building Technologies Program - This fact sheet discusses the Advanced Energy Design Guides (AEDGs) and how they...

  15. A Review of Hazardous Chemical Species Associated with CO2 Capture from Coal-Fired Power Plants and Their Potential Fate in CO2 Geologic Storage

    E-Print Network [OSTI]

    Apps, J.A.

    2006-01-01T23:59:59.000Z

    from combustion and gasification of coal – an equilibriumHolysh, M. 2005. Coke Gasification: Advanced technology forfrom a Coal-Fired Gasification Plant. Final Report, December

  16. Bio/Pharmaceutical Quality Assurance Supervisor/Manager Open Applicant Pool BioMARC/IDRC/OVPR/CSU

    E-Print Network [OSTI]

    Stephens, Graeme L.

    Bio/Pharmaceutical Quality Assurance Supervisor/Manager Open Applicant Pool Bio at the end of this document. The jobs covered in this pool include: LS0054 ­ Quality Assurance Supervisor/Manager Job description of the QA Supervisor/Manager position: This position requires strong knowledge

  17. UBC Social Ecological Economic Development Studies (SEEDS) Student Report Life Cycle Assessment of UBC Faculty of Pharmaceutical Sciences Building

    E-Print Network [OSTI]

    ­ which aims to support the development of the field of life cycle assessment (LCA). The informationUBC Social Ecological Economic Development Studies (SEEDS) Student Report Life Cycle Assessment.sianchuk@gmail.com #12;2 | P a g e Life Cycle Assessment of UBC Faculty of Pharmaceutical Sciences Building CIVL 498E

  18. GASIFICATION PLANT COST AND PERFORMANCE OPTIMIZATION

    SciTech Connect (OSTI)

    Samuel S. Tam

    2002-05-01T23:59:59.000Z

    The goal of this series of design and estimating efforts was to start from the as-built design and actual operating data from the DOE sponsored Wabash River Coal Gasification Repowering Project and to develop optimized designs for several coal and petroleum coke IGCC power and coproduction projects. First, the team developed a design for a grass-roots plant equivalent to the Wabash River Coal Gasification Repowering Project to provide a starting point and a detailed mid-year 2000 cost estimate based on the actual as-built plant design and subsequent modifications (Subtask 1.1). This unoptimized plant has a thermal efficiency of 38.3% (HHV) and a mid-year 2000 EPC cost of 1,681 $/kW. This design was enlarged and modified to become a Petroleum Coke IGCC Coproduction Plant (Subtask 1.2) that produces hydrogen, industrial grade steam, and fuel gas for an adjacent Gulf Coast petroleum refinery in addition to export power. A structured Value Improving Practices (VIP) approach was applied to reduce costs and improve performance. The base case (Subtask 1.3) Optimized Petroleum Coke IGCC Coproduction Plant increased the power output by 16% and reduced the plant cost by 23%. The study looked at several options for gasifier sparing to enhance availability. Subtask 1.9 produced a detailed report on this availability analyses study. The Subtask 1.3 Next Plant, which retains the preferred spare gasification train approach, only reduced the cost by about 21%, but it has the highest availability (94.6%) and produces power at 30 $/MW-hr (at a 12% ROI). Thus, such a coke-fueled IGCC coproduction plant could fill a near term niche market. In all cases, the emissions performance of these plants is superior to the Wabash River project. Subtasks 1.5A and B developed designs for single-train coal and coke-fueled power plants. This side-by-side comparison of these plants, which contain the Subtask 1.3 VIP enhancements, showed their similarity both in design and cost (1,318 $/kW for the coal plant and 1,260 $/kW for the coke plant). Therefore, in the near term, a coke IGCC power plant could penetrate the market and provide a foundation for future coal-fueled facilities. Subtask 1.6 generated a design, cost estimate and economics for a multiple train coal-fueled IGCC powerplant, also based on the Subtaks 1.3 cases. The Subtask 1.6 four gasification train plant has a thermal efficiency of 40.6% (HHV) and cost 1,066 $/kW. The single-train advanced Subtask 1.4 plant, which uses an advanced ''G/H-class'' combustion turbine, can have a thermal efficiency of 45.4% (HHV) and a plant cost of 1,096 $/kW. Multi-train plants will further reduce the cost. Again, all these plants have superior emissions performance. Subtask 1.7 developed an optimized design for a coal to hydrogen plant. At current natural gas prices, this facility is not competitive with hydrogen produced from natural gas. The preferred scenario is to coproduce hydrogen in a plant similar to Subtask 1.3, as described above. Subtask 1.8 evaluated the potential merits of warm gas cleanup technology. This study showed that selective catalytic oxidation of hydrogen sulfide (SCOHS) is promising. As gasification technology matures, SCOHS and other improvements identified in this study will lead to further cost reductions and efficiency improvements.

  19. Advanced Coal Wind Hybrid: Economic Analysis

    SciTech Connect (OSTI)

    Phadke, Amol; Goldman, Charles; Larson, Doug; Carr, Tom; Rath, Larry; Balash, Peter; Yih-Huei, Wan

    2008-11-28T23:59:59.000Z

    Growing concern over climate change is prompting new thinking about the technologies used to generate electricity. In the future, it is possible that new government policies on greenhouse gas emissions may favor electric generation technology options that release zero or low levels of carbon emissions. The Western U.S. has abundant wind and coal resources. In a world with carbon constraints, the future of coal for new electrical generation is likely to depend on the development and successful application of new clean coal technologies with near zero carbon emissions. This scoping study explores the economic and technical feasibility of combining wind farms with advanced coal generation facilities and operating them as a single generation complex in the Western US. The key questions examined are whether an advanced coal-wind hybrid (ACWH) facility provides sufficient advantages through improvements to the utilization of transmission lines and the capability to firm up variable wind generation for delivery to load centers to compete effectively with other supply-side alternatives in terms of project economics and emissions footprint. The study was conducted by an Analysis Team that consists of staff from the Lawrence Berkeley National Laboratory (LBNL), National Energy Technology Laboratory (NETL), National Renewable Energy Laboratory (NREL), and Western Interstate Energy Board (WIEB). We conducted a screening level analysis of the economic competitiveness and technical feasibility of ACWH generation options located in Wyoming that would supply electricity to load centers in California, Arizona or Nevada. Figure ES-1 is a simple stylized representation of the configuration of the ACWH options. The ACWH consists of a 3,000 MW coal gasification combined cycle power plant equipped with carbon capture and sequestration (G+CC+CCS plant), a fuel production or syngas storage facility, and a 1,500 MW wind plant. The ACWH project is connected to load centers by a 3,000 MW transmission line. In the G+CC+CCS plant, coal is gasified into syngas and CO{sub 2} (which is captured). The syngas is burned in the combined cycle plant to produce electricity. The ACWH facility is operated in such a way that the transmission line is always utilized at its full capacity by backing down the combined cycle (CC) power generation units to accommodate wind generation. Operating the ACWH facility in this manner results in a constant power delivery of 3,000 MW to the load centers, in effect firming-up the wind generation at the project site.

  20. Minipig and beagle animal model genomes aid species selection in pharmaceutical discovery and development

    SciTech Connect (OSTI)

    Vamathevan, Jessica J., E-mail: jessica.j.vamathevan@gsk.com [Computational Biology, Quantitative Sciences, GlaxoSmithKline, Stevenage (United Kingdom); Hall, Matthew D.; Hasan, Samiul; Woollard, Peter M. [Computational Biology, Quantitative Sciences, GlaxoSmithKline, Stevenage (United Kingdom); Xu, Meng; Yang, Yulan; Li, Xin; Wang, Xiaoli [BGI-Shenzen, Shenzhen (China); Kenny, Steve [Safety Assessment, PTS, GlaxoSmithKline, Ware (United Kingdom); Brown, James R. [Computational Biology, Quantitative Sciences, GlaxoSmithKline, Collegeville, PA (United States); Huxley-Jones, Julie [UK Platform Technology Sciences (PTS) Operations and Planning, PTS, GlaxoSmithKline, Stevenage (United Kingdom); Lyon, Jon; Haselden, John [Safety Assessment, PTS, GlaxoSmithKline, Ware (United Kingdom); Min, Jiumeng [BGI-Shenzen, Shenzhen (China); Sanseau, Philippe [Computational Biology, Quantitative Sciences, GlaxoSmithKline, Stevenage (United Kingdom)

    2013-07-15T23:59:59.000Z

    Improving drug attrition remains a challenge in pharmaceutical discovery and development. A major cause of early attrition is the demonstration of safety signals which can negate any therapeutic index previously established. Safety attrition needs to be put in context of clinical translation (i.e. human relevance) and is negatively impacted by differences between animal models and human. In order to minimize such an impact, an earlier assessment of pharmacological target homology across animal model species will enhance understanding of the context of animal safety signals and aid species selection during later regulatory toxicology studies. Here we sequenced the genomes of the Sus scrofa Göttingen minipig and the Canis familiaris beagle, two widely used animal species in regulatory safety studies. Comparative analyses of these new genomes with other key model organisms, namely mouse, rat, cynomolgus macaque, rhesus macaque, two related breeds (S. scrofa Duroc and C. familiaris boxer) and human reveal considerable variation in gene content. Key genes in toxicology and metabolism studies, such as the UGT2 family, CYP2D6, and SLCO1A2, displayed unique duplication patterns. Comparisons of 317 known human drug targets revealed surprising variation such as species-specific positive selection, duplication and higher occurrences of pseudogenized targets in beagle (41 genes) relative to minipig (19 genes). These data will facilitate the more effective use of animals in biomedical research. - Highlights: • Genomes of the minipig and beagle dog, two species used in pharmaceutical studies. • First systematic comparative genome analysis of human and six experimental animals. • Key drug toxicology genes display unique duplication patterns across species. • Comparison of 317 drug targets show species-specific evolutionary patterns.

  1. Horizontal Advanced Tensiometer

    DOE Patents [OSTI]

    Hubbell, Joel M.; Sisson, James B.

    2004-06-22T23:59:59.000Z

    An horizontal advanced tensiometer is described that allows the monitoring of the water pressure of soil positions, particularly beneath objects or materials that inhibit the use of previous monitoring wells. The tensiometer includes a porous cup, a pressure transducer (with an attached gasket device), an adaptive chamber, at least one outer guide tube which allows access to the desired horizontal position, a transducer wire, a data logger and preferably an inner guide tube and a specialized joint which provides pressure on the inner guide tube to maintain the seal between the gasket of the transducer and the adaptive chamber.

  2. Advanced Manufacture of Reflectors

    Broader source: Energy.gov [DOE]

    The Advance Manufacture of Reflectors fact sheet describes a SunShot Initiative project being conducted research team led by the University of Arizona, which is working to develop a novel method for shaping float glass. The technique developed by this research team can drastically reduce the time required for the shaping step. By enabling mass production of solar concentrating mirrors at high speed, this project should lead to improved performance and as much as a 40% reduction in manufacturing costs for reflectors made in very high volume.

  3. Advanced Manufacturing Office Overview

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarly Career Scientists' ResearchThe Office ofReporting (Connecticut)41AdamEnergyAdvanced DOE Workshop:

  4. Advanced Materials | ORNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinanInformation InInformationCenterResearch Highlights MediaFuelAbout Us >Portal Advanced

  5. Advanced Feedstock Supply System

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-Up fromDepartment of EnergyAdministrative2 DOE Hydrogen andEnzymeAdvanced Feedstock

  6. Advanced Simulation Capability

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of Energy Power Systems EngineeringDepartment of EnergyAbout UsAdvanced Modeling &NuclearNewsletter3

  7. Advanced Simulation Capability

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of Energy Power Systems EngineeringDepartment of EnergyAbout UsAdvanced Modeling

  8. Advanced Simulation Capability

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of Energy Power Systems EngineeringDepartment of EnergyAbout UsAdvanced Modeling2 Annual Report

  9. Advanced Simulation Capability for

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of Energy Power Systems EngineeringDepartment of EnergyAbout UsAdvanced Modeling2 Annual Reportfor

  10. Geothermal: Advanced Search

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-SeriesFlickr Flickr Editor'sshortGeothermal Heat Pumps GeothermalAdvanced Search

  11. Advanced Conversion Roadmap Workshop

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:Year in Review: Top Five EERE Blog Posts1-034 Advance Patent WaiverLeslie Pezzullo Office of the

  12. Advanced Combustion FAQs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth (AOD)ProductssondeadjustsondeadjustAbout the Building TechnologiesS1!4T opAddress:AdolphusAdvanced

  13. Advanced Photon Source

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth (AOD)ProductssondeadjustsondeadjustAbout the BuildingInnovation Portal AdvancedMethods Home Group Members

  14. Advanced Photon Source

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth (AOD)ProductssondeadjustsondeadjustAbout the BuildingInnovation Portal AdvancedMethods Home Group

  15. Advanced Photon Source

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth (AOD)ProductssondeadjustsondeadjustAbout the BuildingInnovation Portal AdvancedMethods Home GroupISM Day -

  16. Advanced Photon Source

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth (AOD)ProductssondeadjustsondeadjustAbout the BuildingInnovation Portal AdvancedMethods Home GroupISM Day

  17. Advanced Photon Source

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth (AOD)ProductssondeadjustsondeadjustAbout the BuildingInnovation Portal AdvancedMethods Home GroupISM Day0

  18. Advanced Rooftop Unit Control

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth (AOD)ProductssondeadjustsondeadjustAbout the BuildingInnovation Portal AdvancedMethodsServices »

  19. Advanced Studies Institute

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth (AOD)ProductssondeadjustsondeadjustAbout the BuildingInnovation PortalScience of Signatures Advanced

  20. Advanced Target Effects Modeling

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth (AOD)ProductssondeadjustsondeadjustAbout the BuildingInnovation PortalScience of SignaturesAdvanced Target

  1. Advanced Ultraviolet Spectroradiometer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth (AOD)ProductssondeadjustsondeadjustAbout the BuildingInnovation PortalScience ofTechnologyMoreAdvanced

  2. AdvAnced

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc Documentation RUCProductstwrmrAre theAdministrator Referencesalkali metalsTiO2(110). | AdvAnced

  3. Advanced Vehicle Electrification and Transportation Sector Electrifica...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    More Documents & Publications Advanced Vehicle Electrification and Transportation Sector Electrification Plug-in Hybrid (PHEV) Vehicle Technology Advancement and...

  4. Advanced Battery Materials Characterization: Success stories...

    Broader source: Energy.gov (indexed) [DOE]

    Advanced Battery Materials Characterization: Success stories from the High Temperature Materials Laboratory (HTML) User Program Advanced Battery Materials Characterization: Success...

  5. SCR Performance Optimization Through Advancements in Aftertreatment...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Performance Optimization Through Advancements in Aftertreatment Packaging SCR Performance Optimization Through Advancements in Aftertreatment Packaging The impact of improved urea...

  6. Smith Electric Vehicles: Advanced Vehicle Electrification + Transporta...

    Broader source: Energy.gov (indexed) [DOE]

    Smith Electric Vehicles: Advanced Vehicle Electrification + Transportation Sector Electrification Smith Electric Vehicles: Advanced Vehicle Electrification + Transportation Sector...

  7. Waste Treatment Plant Overview

    Office of Environmental Management (EM)

    contracted Bechtel National, Inc., to design and build the world's largest radioactive waste treatment plant. The Waste Treatment and Immobilization Plant (WTP), also known as the...

  8. Integrated intelligent systems in advanced reactor control rooms

    SciTech Connect (OSTI)

    Beckmeyer, R.R.

    1989-01-01T23:59:59.000Z

    An intelligent, reactor control room, information system is designed to be an integral part of an advanced control room and will assist the reactor operator's decision making process by continuously monitoring the current plant state and providing recommended operator actions to improve that state. This intelligent system is an integral part of, as well as an extension to, the plant protection and control systems. This paper describes the interaction of several functional components (intelligent information data display, technical specifications monitoring, and dynamic procedures) of the overall system and the artificial intelligence laboratory environment assembled for testing the prototype. 10 refs., 5 figs.

  9. System Definition and Analysis: Power Plant Design and Layout

    SciTech Connect (OSTI)

    NONE

    1996-05-01T23:59:59.000Z

    This is the Topical report for Task 6.0, Phase 2 of the Advanced Turbine Systems (ATS) Program. The report describes work by Westinghouse and the subcontractor, Gilbert/Commonwealth, in the fulfillment of completing Task 6.0. A conceptual design for critical and noncritical components of the gas fired combustion turbine system was completed. The conceptual design included specifications for the flange to flange gas turbine, power plant components, and balance of plant equipment. The ATS engine used in the conceptual design is an advanced 300 MW class combustion turbine incorporating many design features and technologies required to achieve ATS Program goals. Design features of power plant equipment and balance of plant equipment are described. Performance parameters for these components are explained. A site arrangement and electrical single line diagrams were drafted for the conceptual plant. ATS advanced features include design refinements in the compressor, inlet casing and scroll, combustion system, airfoil cooling, secondary flow systems, rotor and exhaust diffuser. These improved features, integrated with prudent selection of power plant and balance of plant equipment, have provided the conceptual design of a system that meets or exceeds ATS program emissions, performance, reliability-availability-maintainability, and cost goals.

  10. Advanced thermochemical hydrogen cycles

    SciTech Connect (OSTI)

    Hollabaugh, C.M.; Bowman, M.G.

    1981-01-01T23:59:59.000Z

    The overall objective of this program is to contribute to the development of practical thermochemical cycles for the production of hydrogen from water. Specific goals are: investigate and evaluate the technical and economic viability of thermochemical cycles as an advanced technology for producing hydrogen from water; investigate and evaluate the engineering principles involved in interfacing individual thermochemical cycles with the different thermal energy sources (high temperature fission, solar, and fusion); and conduct a continuing research and development effort to evaluate the use of solid sulfates, oxides and other compounds as potentially advanced cycles and as alternates to H/sub 2/SO/sub 4/ based cycles. Basic thermochemistry studies have been completed for two different steps in the decomposition of bismuth sulfate. Two different bismuth sulfate cycles have been defined for different sulfuric acid strengths. The eventual best cycle will depend on energy required to form sulfuric acid at different concentrations. A solids decomposition facility has been constructed and practical studies of solid decompositions are being conducted. The facility includes a rotary kiln system and a dual-particle fluidized bed system. Evaluation of different types of cycles for coupling with different heat sources is continuing.

  11. Future Transient Testing of Advanced Fuels

    SciTech Connect (OSTI)

    Jon Carmack

    2009-09-01T23:59:59.000Z

    The transient in-reactor fuels testing workshop was held on May 4–5, 2009 at Idaho National Laboratory. The purpose of this meeting was to provide a forum where technical experts in transient testing of nuclear fuels could meet directly with technical instrumentation experts and nuclear fuel modeling and simulation experts to discuss needed advancements in transient testing to support a basic understanding of nuclear fuel behavior under off-normal conditions. The workshop was attended by representatives from Commissariat à l'Énergie Atomique CEA, Japanese Atomic Energy Agency (JAEA), Department of Energy (DOE), AREVA, General Electric – Global Nuclear Fuels (GE-GNF), Westinghouse, Electric Power Research Institute (EPRI), universities, and several DOE national laboratories. Transient testing of fuels and materials generates information required for advanced fuels in future nuclear power plants. Future nuclear power plants will rely heavily on advanced computer modeling and simulation that describes fuel behavior under off-normal conditions. TREAT is an ideal facility for this testing because of its flexibility, proven operation and material condition. The opportunity exists to develop advanced instrumentation and data collection that can support modeling and simulation needs much better than was possible in the past. In order to take advantage of these opportunities, test programs must be carefully designed to yield basic information to support modeling before conducting integral performance tests. An early start of TREAT and operation at low power would provide significant dividends in training, development of instrumentation, and checkout of reactor systems. Early start of TREAT (2015) is needed to support the requirements of potential users of TREAT and include the testing of full length fuel irradiated in the FFTF reactor. The capabilities provided by TREAT are needed for the development of nuclear power and the following benefits will be realized by the refurbishment and restart of TREAT. •TREAT is an absolute necessity in the suite of reactor fuel test capabilities •TREAT yields valuable information on reactivity effects, margins to failure, fuel dispersal, and failure propagation •Most importantly, interpretation of TREAT experiment results is a stringent test of the integrated understanding of fuel performance.

  12. Oxidation of alloys targeted for advanced steam turbines

    SciTech Connect (OSTI)

    Holcomb, G.R.; Covino, B.S., Jr.; Bullard, S.J.; Ziomek-Moroz, M.; Alman, D.E.

    2006-03-12T23:59:59.000Z

    Ultra supercritical (USC) power plants offer the promise of higher efficiencies and lower emissions. Current goals of the U.S. Department of Energy’s Advanced Power Systems Initiatives include coal generation at 60% efficiency, which would require steam temperatures of up to 760°C. This research examines the steamside oxidation of alloys for use in USC systems, with emphasis placed on applications in high- and intermediate-pressure turbines.

  13. Advanced Turbine Systems Program: Conceptual design and product development

    SciTech Connect (OSTI)

    NONE

    1996-12-31T23:59:59.000Z

    Objective is to provide the conceptual design and product development plant for an ultra high efficiency, environmentally superior, and cost competitive industrial gas turbine system to be commercialized by the year 2000 (secondary objective is to begin early development of technologies critical to the success of ATS). This report addresses the remaining 7 of the 9 subtasks in Task 8, Design and Test of Critical Components: catalytic combustion, recuperator, high- temperature turbine disc, advanced control system, and ceramic materials.

  14. Advanced Manufacturing | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Better Buildings, Better Plants Clean Energy Manufacturing Initiative Combined Heat and Power Innovative Manufacturing Initiative National Network for Manufacturing Innovation...

  15. Alloys for advanced steam turbines--Oxidation behavior

    SciTech Connect (OSTI)

    Holcomb, G.R.

    2007-10-01T23:59:59.000Z

    Advanced or ultra supercritical (USC) steam power plants offer the promise of higher efficiencies and lower emissions. Current goals of the U.S. Department of Energy (DOE) include power generation from coal at 60% efficiency, which would require steam temperatures of up to 760°C. Current research on the oxidation of candidate materials for advanced steam turbines is presented with a focus on a methodology for estimating chromium evaporation rates from protective chromia scales. The high velocities and pressures of advanced steam turbines lead to evaporation predictions as high as 5 × 10-8 kg m-2s-1 of CrO2(OH)2(g) at 760°C and 34.5 MPa. This is equivalent to 0.077 mm per year of solid Cr loss.

  16. Advanced Integrated Systems Technology Development

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    conditioning in buildings featuring integrated design withconditioning in buildings featuring integrated design withof a building with advanced integrated design involving one

  17. Fuels for Advanced Combustion Engines

    Broader source: Energy.gov (indexed) [DOE]

    not finalized, AARF is considering: * 2 nd generation biofuels * Non-food sources * Jatropha * Algae * Lignocellulose * Other biomass-to-liquid * Advanced processing of edible...

  18. ADVANCED HYBRID PARTICULATE COLLECTOR

    SciTech Connect (OSTI)

    Stanley Miller; Rich Gebert; William Swanson

    1999-11-01T23:59:59.000Z

    A new concept in particulate control, called an advanced hybrid particulate collector (AHPC), is being developed under funding from the US Department of Energy. The AHPC combines the best features of electrostatic precipitators (ESPs) and baghouses in a manner that has not been done before. The AHPC concept consists of a combination of fabric filtration and electrostatic precipitation in the same housing, providing major synergism between the two collection methods, both in the particulate collection step and in the transfer of dust to the hopper. The AHPC provides ultrahigh collection efficiency, overcoming the problem of excessive fine-particle emission with conventional ESPs, and it solves the problem of reentrainment and collection of dust in conventional baghouses. The AHPC is currently being tested at the 2.7-MW scale at the Big Stone power station.

  19. Advanced drilling systems study.

    SciTech Connect (OSTI)

    Pierce, Kenneth G.; Livesay, Billy Joe; Finger, John Travis (Livesay Consultants, Encintas, CA)

    1996-05-01T23:59:59.000Z

    This report documents the results of a study of advanced drilling concepts conducted jointly for the Natural Gas Technology Branch and the Geothermal Division of the U.S. Department of Energy. A number of alternative rock cutting concepts and drilling systems are examined. The systems cover the range from current technology, through ongoing efforts in drilling research, to highly speculative concepts. Cutting mechanisms that induce stress mechanically, hydraulically, and thermally are included. All functions necessary to drill and case a well are considered. Capital and operating costs are estimated and performance requirements, based on comparisons of the costs for alternative systems to conventional drilling technology, are developed. A number of problems common to several alternatives and to current technology are identified and discussed.

  20. Advanced Containment System

    DOE Patents [OSTI]

    Kostelnik, Kevin M. (Idaho Falls, ID); Kawamura, Hideki (Tokyo, JP); Richardson, John G. (Idaho Falls, ID); Noda, Masaru (Tokyo, JP)

    2005-05-24T23:59:59.000Z

    An advanced containment system for containing buried waste and associated leachate. A trench is dug on either side of the zone of interest containing the buried waste so as to accommodate a micro tunnel boring machine. A series of small diameter tunnels are serially excavated underneath the buried waste. The tunnels are excavated by the micro tunnel boring machine at a consistent depth and are substantially parallel to each other. As tunneling progresses, steel casing sections are connected end to end in the excavated portion of the tunnel so that a steel tube is formed. Each casing section has complementary interlocking structure running its length that interlocks with complementary interlocking structure on the adjacent casing section. Thus, once the first tube is emplaced, placement of subsequent tubes is facilitated by the complementary interlocking structure on the adjacent, previously placed, casing sections.

  1. Advanced Containment System

    DOE Patents [OSTI]

    Kostelnik, Kevin M. (Idaho Falls, ID); Kawamura, Hideki (Tokyo, JP); Richardson, John G. (Idaho Falls, ID); Noda, Masaru (Tokyo, JP)

    2004-10-12T23:59:59.000Z

    An advanced containment system for containing buried waste and associated leachate. A trench is dug on either side of the zone of interest containing the buried waste so as to accommodate a micro tunnel boring machine. A series of small diameter tunnels are serially excavated underneath the buried waste. The tunnels are excavated by the micro tunnel boring machine at a consistent depth and are substantially parallel to each other. As tunneling progresses, steel casing sections are connected end to end in the excavated portion of the tunnel so that a steel tube is formed. Each casing section has complementary interlocking structure running its length that interlocks with complementary interlocking structure on the adjacent casing section. Thus, once the first tube is emplaced, placement of subsequent tubes is facilitated by the complementary interlocking structure on the adjacent, previously placed, casing sections.

  2. E-Print Network 3.0 - alien plants transitioning Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Search Powered by Explorit Topic List Advanced Search Sample search results for: alien plants transitioning Page: << < 1 2 3 4 5 > >> 1 5) Management a) How big of a problem...

  3. E-Print Network 3.0 - alien plant control Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Search Powered by Explorit Topic List Advanced Search Sample search results for: alien plant control Page: << < 1 2 3 4 5 > >> 1 5) Management a) How big of a problem is it?...

  4. E-Print Network 3.0 - alien plant invasions Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Search Powered by Explorit Topic List Advanced Search Sample search results for: alien plant invasions Page: << < 1 2 3 4 5 > >> 1 5) Management a) How big of a problem is...

  5. E-Print Network 3.0 - alien plant species Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Search Powered by Explorit Topic List Advanced Search Sample search results for: alien plant species Page: << < 1 2 3 4 5 > >> 1 5) Management a) How big of a problem is it?...

  6. E-Print Network 3.0 - alien plant invaders Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Search Powered by Explorit Topic List Advanced Search Sample search results for: alien plant invaders Page: << < 1 2 3 4 5 > >> 1 5) Management a) How big of a problem is...

  7. E-Print Network 3.0 - aquatic plant biomass Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    biomass Search Powered by Explorit Topic List Advanced Search Sample search results for: aquatic plant biomass Page: << < 1 2 3 4 5 > >> 1 AQUATIC PLAN RESEARCH T CONTROL Summary:...

  8. E-Print Network 3.0 - automobile assembly plant Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Search Powered by Explorit Topic List Advanced Search Sample search results for: automobile assembly plant Page: << < 1 2 3 4 5 > >> 1 Vol. 37, No. 4, JulyAugust 2007, pp....

  9. E-Print Network 3.0 - aquatic plant wastewater Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    wastewater Search Powered by Explorit Topic List Advanced Search Sample search results for: aquatic plant wastewater Page: << < 1 2 3 4 5 > >> 1 1S P R I N G 2 0 1 0 The Magazine...

  10. E-Print Network 3.0 - aquatic plants water Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    water Search Powered by Explorit Topic List Advanced Search Sample search results for: aquatic plants water Page: << < 1 2 3 4 5 > >> 1 NO LONGER HENRY'S HUDSON: EXOTIC SPECIES...

  11. E-Print Network 3.0 - autonomously activated plant Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Report of the ISIS Group Summary: the control systems in the car with the plant being the vehicle and the goals of the autonomous controller... of advanced systems. An autonomous...

  12. NUCLEAR PLANT OPERATIONS AND

    E-Print Network [OSTI]

    Pázsit, Imre

    NUCLEAR PLANT OPERATIONS AND CONTROL KEYWORDS: neutron flux, cur- rent noise, vibration diagnostics: Swedish Nuclear Powe

  13. Ethylene insensitive plants

    SciTech Connect (OSTI)

    Ecker, Joseph R. (Carlsbad, CA); Nehring, Ramlah (La Jolla, CA); McGrath, Robert B. (Philadelphia, PA)

    2007-05-22T23:59:59.000Z

    Nucleic acid and polypeptide sequences are described which relate to an EIN6 gene, a gene involved in the plant ethylene response. Plant transformation vectors and transgenic plants are described which display an altered ethylene-dependent phenotype due to altered expression of EIN6 in transformed plants.

  14. ARIES Town Meeting on "Edge Plasma Physics and Plasma Material Interactions in the Fusion Power Plant Regime"

    E-Print Network [OSTI]

    Interactions in the Fusion Power Plant Regime. (ARIES Town Meetings are held approximately once every 1-2 years provide an opportunity for increased interactions between researchers in the field and the power plant in order to advance this field toward the power plant regime?, and (3) What contributions can new devices

  15. Exploration of Compact Stellarators as Power Plants: Initial Results from ARIES-CS Study Farrokh Najmabadi and the ARIES Team

    E-Print Network [OSTI]

    California at San Diego, University of

    Exploration of Compact Stellarators as Power Plants: Initial Results from ARIES-CS Study Farrokh study of compact stellarators as power plants, ARIES-CS, was initiated recently to advance our. It appears that devices with an overall size similar to those envisioned for tokamak power plants

  16. Conference committees Chairman of the conference "New Nuclear Power Plants in the Netherlands", June 21-22, 2011,

    E-Print Network [OSTI]

    Conference committees Chairman of the conference "New Nuclear Power Plants in the Netherlands Nuclear Power Plants, September 15-19, 2003, Kyoto, Japan. Session chairman GENES4/ANP2003 ,,International Conference on Global Environment and Advanced Nuclear Power Plants, September 15-19, 2003, Kyoto

  17. The advanced test reactor strategic evaluation program

    SciTech Connect (OSTI)

    Buescher, B.J.; Majumdar, D.; Croucher, D.W.

    1989-01-01T23:59:59.000Z

    Since the Chernobly accident, the safety of test reactors and irradiation facilities has been critically evaluated from the public's point of view. A systematic evaluation of all safety, environmental, and operational issues must be made in an integrated manner to prioritize actions to maximize benefits while minimizing costs. Such a proactive program has been initiated at the Advanced Test Reactor (ATR). This program, called the Strategic Evaluation Program (STEP), is being conducted for the ATR to provide integrated safety and operational reviews of the reactor against the standards applied to licensed commercial power reactors. This has taken into consideration the lessons learned by the US Nuclear Regulatory Commission (NRC) in its Systematic Evaluation Program (SEP) and the follow-on effort known as the Integrated Safety Assessment Program (ISAP). The SEP was initiated by the NRC to review the designs of older operating nuclear power plants to confirm and document their safety. The ATR STEP objectives are discussed.

  18. AVESTAR Center for operational excellence of electricity generation plants

    SciTech Connect (OSTI)

    Zitney, S.

    2012-01-01T23:59:59.000Z

    To address challenges in attaining operational excellence for clean energy plants, the U.S.Department of Energy’s National Energy Technology Laboratory has launched a world-class facility for Advanced Virtual Energy Simulation Training and Research (AVESTAR™). The AVESTAR Center brings together state-of-the-art, real time,high-fidelity dynamic simulators with operator training systems and 3D virtual immersive training systems into an integrated energy plant and control room environment.

  19. Plant fatty acid hydroxylases

    DOE Patents [OSTI]

    Somerville, Chris (Portola Valley, CA); Broun, Pierre (Burlingame, CA); van de Loo, Frank (Lexington, KY)

    2001-01-01T23:59:59.000Z

    This invention relates to plant fatty acyl hydroxylases. Methods to use conserved amino acid or nucleotide sequences to obtain plant fatty acyl hydroxylases are described. Also described is the use of cDNA clones encoding a plant hydroxylase to produce a family of hydroxylated fatty acids in transgenic plants. In addition, the use of genes encoding fatty acid hydroxylases or desaturases to alter the level of lipid fatty acid unsaturation in transgenic plants is described.

  20. ADVANCED SECOND GENERATION CERAMIC CANDLE FILTERS

    SciTech Connect (OSTI)

    M.A. Alvin

    2002-01-31T23:59:59.000Z

    Through sponsorship from the Department of Energy's National Energy Technology Laboratory (DOE/NETL), development and manufacture of advanced second generation candle filters was undertaken in the early 1990's. Efforts were primarily focused on the manufacture of fracture toughened, 1.5 m, continuous fiber ceramic composite (CFCC) and filament wound candle filters by 3M, McDermott, DuPont Lanxide Composites, and Techniweave. In order to demonstrate long-term thermal, chemical, and mechanical stability of the advanced second generation candle filter materials, Siemens Westinghouse initiated high temperature, bench-scale, corrosion testing of 3M's CVI-SiC and DuPont's PRD-66 mini-candles, and DuPont's CFCC SiC-SiC and IF&P Fibrosic{sup TM} coupons under simulated, pressurized fluidized-bed combustion (PFBC) conditions. This effort was followed by an evaluation of the mechanical and filtration performance of the advanced second generation filter elements in Siemens Westinghouse's bench-scale PFBC test facility in Pittsburgh, Pennsylvania. Arrays of 1.4-1.5 m 3M CVI-SiC, DuPont PRD-66, DuPont SiC-SiC, and IF&P Fibrosic{sup TM} candles were subjected to steady state process operating conditions, increased severity thermal transients, and accelerated pulse cycling test campaigns which represented {approx}1760 hours of equivalent filter operating life. Siemens Westinghouse subsequently participated in early material surveillance programs which marked entry of the 3M CVI-SiC and DuPont PRD-66 candle filters in Siemens Westinghouse Advanced Particulate Filtration (APF) system at the American Electric Power (AEP) Tidd Demonstration Plant in Brilliant, Ohio. Siemens Westinghouse then conducted an extended, accelerated life, qualification program, evaluating the performance of the 3M, McDermott, and Techniweave oxide-based CFCC filter elements, modified DuPont PRD-66 elements, and the Blasch, Scapa Cerafil{sup TM}, and Specific Surface monolithic candles for use in the APF system at the Foster Wheeler pressurized circulating fluidized-bed combustion (PCFBC), pilot-scale, test facility in Karhula, Finland. This report presents a summary of these efforts, defining the stability of the various porous ceramic filter materials, as well as component performance and extended life for use in advanced coal-based power systems.