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1

E/EIA  

U.S. Energy Information Administration (EIA) Indexed Site

E/EIA E/EIA -0278 U.S. Depa rtme nt of Energ y Energ y Inform ation Admi nistra tion Assis tant Admi nistra tor for Progr am Deve lopme nt Office of the Cons umpt ion Data Syste m June 1981 01377 9 = 4530 : FED Non res ide ntia l Bui ldin gs u/w & Ene rgy Con sum ptio n Sur vey : Fu el Ch ara cte ris tic s an d Co ns erv ati on Pra cti ces Prepared by: Lynn D. Patinkin, Phillip Windell, Dwight: K. French, Leigh Carleton, Lynda T. Carlson, Kenneth A. Vagts, Leslie Whitaker, Tom Woteki, Wilbert Laird, and Laura Wong. IMPORTANT NOTICE As required by government regulation, EIA will conduct the annual review of our mailing list during the next several weeks. If you are on the mailing list, you will soon receive a post card listing your name and address as they appear on our files. If you wish to continue to receive our publications, you must mail

2

Energy Conmation Program tor  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

44086 Federal Register / Vol. 45, No. 127 / Monday. J 44086 Federal Register / Vol. 45, No. 127 / Monday. J u n e 30, 1980 / Proposed Rules 10 CFR Part 430 room air conditioners, home hetliing impact of setting energy efficiency Energy Conmation Program tor equipment, not including furnaces. standards for the ninefypes of Consumer Products kitchen ranges and ovens, central air consumer products covered by the conditioners (cooling only), and notice. Subsequent to publication of this AOECR Deportment o f Energy. furnaces. Stundards for dishwashers, odvance not;,e, advunce notices were A ~ N : Notice of availability of television sets, clothes washers. and published indicating that POE is environmental assessment and finding humidifiera and dehumidifiers are considering energy efficiency staodilrds of no significant impact.

3

Throttling Tor Bandwidth Parasites Technical Report  

E-Print Network (OSTI)

-019 Throttling Tor Bandwidth Parasites Rob Jansen, Paul Syverson, and Nicholas J. Hopper September 23, 2011 #12;#12;Throttling Tor Bandwidth Parasites Rob Jansen Paul Syverson U.S. Naval Research Laboratory {rob.g.jansen

Minnesota, University of

4

A TorPath to TorCoin: Proof-of-Bandwidth Altcoins for Compensating Relays  

E-Print Network (OSTI)

Coin, an "altcoin" that uses the Bitcoin protocol to re- ward relays for contributing bandwidth. Relays "mine" TorCoin is an alternative cryptocurrency, or altcoin, based on the Bitcoin protocol [8]. Unlike Bitcoin, its proof

5

Identifying Proxy Nodes in a Tor Anonymization Circuit Sambuddho Chakravarty  

E-Print Network (OSTI)

agnostic Onion Routing scheme [11] to anonymize the traffic. The strength of the scheme is the use is vulnerable to traffic analysis at- tacks. These attacks can expose the identity of a Tor client or of the proxy nodes used in an anonymous Tor circuit when an adversary can manipulate the traffic entering

Yang, Junfeng

6

Shining Light in Dark Places: Understanding the Tor Network  

E-Print Network (OSTI)

Shining Light in Dark Places: Understanding the Tor Network Damon McCoy1 , Kevin Bauer1 , Dirk-used? (3) Who is using Tor? To sample the results, we show that web traffic makes up the ma- jority latency and high throughput, it is ideal for interac- tive applications such as web browsing, file sharing

7

Attacking Tor through Unpopular Ports Muhammad Aliyu Sulaiman  

E-Print Network (OSTI)

Department King Fahd University of Petroleum and Minerals Dhahran, Saudi Arabia muhalisu@kfupm.edu.sa Sami Zhioua Information and Computer Science Department King Fahd University of Petroleum and Minerals Dhahran of relays (Tor node and Tor relay are used interchangeably in this paper). No one of these The authors would

Almulhem, Ahmad

8

Primary resistance to ATP-competitive mTOR inhibitors for the treatment of solid tumors  

E-Print Network (OSTI)

Q, Zhang J, Gao Y, et al. An ATP-competitive mTOR inhibitorselectivity profiling of ATP-competitive mTOR (mammalianActivity of WYE-125132, an ATP- Competitive and Specific

Ducker, Gregory Stuart

2013-01-01T23:59:59.000Z

9

DOE/EIA-0314(82) Residential Energy Consumption Survey:  

Gasoline and Diesel Fuel Update (EIA)

4(82) 4(82) Residential Energy Consumption Survey: Housing Characteri stics 1982 Published: August 1984 U-'VVv*' ^**" ^ Energy Information Administration Washington, D.C. This public ation is availa ble from the Supe rinten dent of Docu ments , U.S. Gove rnme nt Printin g Office (GPO ). Order ing inform ation and purch ase of this and other Energ y Inform ation Admi nistra tion (EIA) public ations may be obtain ed from the GPO or the ElA's Natio nal Energ y Inform ation Cente r (NEIC ). Ques tions on energ y statis tics

10

On the risks of serving whenever you surf Vulnerabilities in Tor's blocking resistance design  

E-Print Network (OSTI)

approximately 200,000 clients and the rest of the Internet. The goal of Tor is to conceal who communicates of Tor users seem to be using it as a tool for cen- sorship resistance. Since Internet censorship connections exiting Tor is an important feature to prevent abuse complaints, the ability to block connections

Minnesota, University of

11

GATORs Take a Bite Out of mTOR  

Science Journals Connector (OSTI)

GATORs Take a Bite Out of mTOR 10.1126/science...which they call GAP activity toward Rags (GATOR), that acts upstream of the Rag proteins...figure). The eight proteins that comprise GATOR can be divided into two subcomplexes based on...

Reuben J. Shaw

2013-05-31T23:59:59.000Z

12

From Onions to Shallots: Rewarding Tor Relays with TEARS  

E-Print Network (OSTI)

banking using protocols from distributed digital cryp- tocurrency systems like Bitcoin. Shallots the distributed Bitcoin architecture to design a transparent, efficient, and auditable reward system (TEARS existing anonymous Bitcoin protocols to create a type of "altcoin" token system that Tor may utilize

13

The PiTT innovaTor's Guide To commercialization  

E-Print Network (OSTI)

. . . . . . . . . . . . . . . . . . . . . . 3 The Bayh-Dole Act at a Glance. . . . . . . 6 The Pitt Innovator Community . . . . . . . 8 The.Commercialization.Process's Guide to Technology Commercialization will walk you through the commercialization process, fromThe PiTT innovaTor's Guide To technology commercialization U n i v e r s i t y o f P i t t s b U r

Jiang, Huiqiang

14

Vasopressin activates Akt/mTOR pathway in smooth muscle cells cultured in high glucose concentration  

SciTech Connect

Highlights: •AVP induces mTOR phosphorylation in A-10 cells cultured in high glucose concentration. •The mTOR phosphorylation is mediated by the PI3K/Akt pathway activation. •The AVP-induced mTOR phosphorylation inhibited autophagy and stimulated cell proliferation. -- Abstract: Mammalian target of rapamycin (mTOR) complex is a key regulator of autophagy, cell growth and proliferation. Here, we studied the effects of arginine vasopressin (AVP) on mTOR activation in vascular smooth muscle cells cultured in high glucose concentration. AVP induced the mTOR phosphorylation in A-10 cells grown in high glucose, in contrast to cells cultured in normal glucose; wherein, only basal phosphorylation was observed. The AVP-induced mTOR phosphorylation was inhibited by a PI3K inhibitor. Moreover, the AVP-induced mTOR activation inhibited autophagy and increased thymidine incorporation in cells grown in high glucose. This increase was abolished by rapamycin which inhibits the mTORC1 complex formation. Our results suggest that AVP stimulates mTOR phosphorylation by activating the PI3K/Akt signaling pathway and, subsequently, inhibits autophagy and raises cell proliferation in A-10 cells maintained in high glucose concentration.

Montes, Daniela K.; Brenet, Marianne; Muñoz, Vanessa C.; Burgos, Patricia V.; Villanueva, Carolina I. [Department of Physiology, Universidad Austral de Chile, Valdivia 509-9200 (Chile)] [Department of Physiology, Universidad Austral de Chile, Valdivia 509-9200 (Chile); Figueroa, Carlos D. [Department of Anatomy, Histology and Pathology, Universidad Austral de Chile, Valdivia 509-9200 (Chile)] [Department of Anatomy, Histology and Pathology, Universidad Austral de Chile, Valdivia 509-9200 (Chile); González, Carlos B., E-mail: cbgonzal@uach.cl [Department of Physiology, Universidad Austral de Chile, Valdivia 509-9200 (Chile); Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 (United States)

2013-11-29T23:59:59.000Z

15

Radiological Habits Survey: Torness, 2006 This page has been intentionally left blank  

E-Print Network (OSTI)

intentionally left blank #12;3 SUMMARY 5 1. INTRODUCTION 6 1.1 Regulation of radioactive waste discharges 6 1 vegetables in the Torness area (kg/y) Table 20. Adults' consumption rates of potato in the Torness area (kg

16

RapTOR-FINAL 2-7-12  

NLE Websites -- All DOE Office Websites (Extended Search)

Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE- AC04-94AL85000. SAND 2012-0192P RapTOR (Rapid Threat Organism Recognition) Biodetection System for Public Health and Biodefense Challenge Amid concern about bioterrorism threats to national security, there is, in addition to the need for rapid diagnostics for known biothreat agents, another requirement to detect, identify, and characterize unknown biological threats-that is, pathogenic microorganisms not previously encountered and possibly genetically engineered to increase threat and avoid detection. The

17

Regulation of mTOR complex 1 in response to growth factors and nutrients  

E-Print Network (OSTI)

In multicellular organisms, cells ensure the simultaneous availability of growth factors and nutrients before they invest in cellular processes that lead to growth. The TOR kinase is a master regulator of cellular growth ...

Sancak, Yasemin S. (Yasemin Shechner)

2010-01-01T23:59:59.000Z

18

Shadow: Running Tor in a Box for Accurate and Efficient Experimentation Technical Report  

E-Print Network (OSTI)

Rob Jansen and Nicholas J. Hopper September 23, 2011 #12;#12;Shadow: Running Tor in a Box for Accurate and Efficient Experimentation Rob Jansen U.S. Naval Research Laboratory rob.g.jansen@nrl.navy.mil Nicholas

Minnesota, University of

19

Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: its potential use in the treatment of bladder cancers.  

E-Print Network (OSTI)

Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: its potential use in the treatment involved in the PI3K/AKT/mTOR signaling pathway that occupies a major place in the etiology of these tumors. Here, we describe the mutations leading to constitutive activation of the PI3K/AKT/mTOR pathway

Paris-Sud XI, Université de

20

Energy-based Control of a Distributed Solar Collector Tor A. Johansena  

E-Print Network (OSTI)

Energy-based Control of a Distributed Solar Collector Field Tor A. Johansena Camilla Storaaa that the primary energy source, solar radiation, cannot be manipulated. The distributed solar collector eld may, Norway. Model-based control of the outlet temperature of a distributed solar col- lector eld is studied

Johansen, Tor Arne

Note: This page contains sample records for the topic "admi nistra tor" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Scineghe08 8-11/10/08 Aldo Morselli, INFN Roma Tor Vergata 1 Aldo Morselli  

E-Print Network (OSTI)

Dark Matter from Space #12;Scineghe08 8-11/10/08 Aldo Morselli, INFN Roma Tor Vergata 2 Dark Energy 76% CDM Baryons 4%Cold Dark Matter 20% Dark Matter in the era of precision cosmology CDM ~ 5 b #12: primary spectra injection index implemented in Galprop ( Strong & Moskalenko, available on the Web) #12

Morselli, Aldo

22

mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+  

E-Print Network (OSTI)

mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+ Channels to Adapt to Metabolic State Chunlei cytosolic ATP levels is not well understood. Here, we identify an endolysosomal ATP-sensitive Na+ channel (lysoNaATP). The channel is a complex formed by two-pore channels (TPC1 and TPC2), ion channels

Clapham, David E.

23

Free-Piston Diesel Engine Dynamics and Control Tor A. Johansen1, Olav Egeland  

E-Print Network (OSTI)

Free-Piston Diesel Engine Dynamics and Control Tor A. Johansen1, Olav Egeland , Erling Aa. Kv rner ASA, Postboks 169, N-1325 Lysaker, Norway. Abstract Free-piston diesel engines. This paper present a dynamic mathematical model of a free-piston diesel engine, a control oriented dynamic

Johansen, Tor Arne

24

INERTIAL CONTROL OF MARINE ENGINES AND PROPELLERS Damir Radan*, Asgeir J. Srensen*, Tor Arne Johansen  

E-Print Network (OSTI)

, marine generators and main propulsion engines. Copyright © 2007 IFAC Keywords: Propellers, Inertia, Propulsion, Marine, Engines, Noise, Observers 1. INTRODUCTION When vessel operates in harsh weatherINERTIAL CONTROL OF MARINE ENGINES AND PROPELLERS Damir Radan*, Asgeir J. Sørensen*, Tor Arne

Johansen, Tor Arne

25

RapTOR: Automated sequencing library preparation and suppression for rapid pathogen characterization ( 7th Annual SFAF Meeting, 2012)  

ScienceCinema (OSTI)

Todd Lane on "RapTOR: Automated sequencing library preparation and suppression for rapid pathogen characterization" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

Lane, Todd [SNL

2013-02-11T23:59:59.000Z

26

Decent intersection and Tor-rigidity for modules over local hypersurfaces  

E-Print Network (OSTI)

TRANSACTIONS OF THE AMERICAN MATHEMATICAL SOCIETY Volume 365, Number 6, June 2013, Pages 2803–2821 S 0002-9947(2012)05574-7 Article electronically published on November 1, 2012 DECENT INTERSECTION AND TOR-RIGIDITY FOR MODULES OVER LOCAL.... But by the Grothendieck-Lefschetz Theorem, the Picard group of X = Spec(R)? {m} is 0. Since X is regular, the Picard group of X is the same as CH1(X) = CH1(R). #2; Example 3.7. Let R be a dimension 3 hypersurface which is a UFD, for example R = C[[x, y, u, v

Dao, Hailong

2013-10-01T23:59:59.000Z

27

Abstract 2322: The KIAA1549:BRAF fusion gene regulates mTOR signaling and gliomagenesis in a cell type- and brain region-specific manner.  

Science Journals Connector (OSTI)

...The KIAA1549:BRAF fusion gene regulates mTOR...gliomagenesis in a cell type- and brain region-specific...region- and cell type-specific growth...also observed in fusion BRAF-associated...The KIAA1549:BRAF fusion gene regulates mTOR...gliomagenesis in a cell type- and brain region-specific...

Aparna Kaul; Yi-Hsien Chen; Ryan J. Emnett; Sonika Dahiya; and David Gutmann

2013-08-14T23:59:59.000Z

28

Abstract PD1-8: Acquired resistance to rapamycin and mTOR kinase inhibitors is mediated by non-overlapping mutations in distinct sites in the mTOR protein  

Science Journals Connector (OSTI)

...from mutational activation of receptor tyrosine kinases, PI3K signaling or inactivating mutations of the Tuberous Sclerosis or GATOR complexes as well as the LKB/AMP kinase pathway. The prevalence of mTOR activation in cancer has led to the development of...

V Rodrik-Outmezguine; Z Yao; M Berger; E De Stanchina; T Klinowska; D Barratt; J Baselga; N Rosen

2013-12-15T23:59:59.000Z

29

Aldo Morselli, INFN Roma Tor Vergata ITEP Winter School Moscow 12-19 February 2013! 1! Search for Dark matter  

E-Print Network (OSTI)

! Dark Energy 76% CDM Baryons 4%Cold Dark Matter 20% Dark Matter in the era of precision cosmology CDM for Dark matter Aldo Morselli INFN Roma Tor Vergata Moscow February 12-19, 2013 41th ITEP Winter School #12 precision studies of 5 % of our Universe -> Discovery of the Standard Model The LHC is delivering data We

Morselli, Aldo

30

a J. C. Clarke, Contract FEOM 8 J. P. Morgan, Assist tor, Pznduction Division  

Office of Legacy Management (LM)

J. C. Clarke, Contract J. C. Clarke, Contract FEOM 8 J. P. Morgan, Assist tor, Pznduction Division SUBJECT: CONTRACT PROPCX3AL OF r) ELECTRO MXTALLURGICAL DIVISION SYMBOL: PADtJPM UNION CARBIDE & CAFLBON CORPORATION i' .:' CONTRACT NO. W-7405 EN&14 4. . A; BACKGROUND 18 The vacuum casting facilities at the Electra ~etallnrgical Division at Niagara Falls, New York, currently in standby, are needed for the vacuum casting of slrconium sponge to ingot for subsequent con- version to zirconium shapes for the Naval Critical hequiremento . The program has been approved by the &shington Division of heactor Development through the Washington Production Division, Monies are available from operations budget for FY 1950 and FY 1951 under the Titanium Alloy Manufacturing Division of National &ad Company

31

Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes  

SciTech Connect

We reported previously that the stability of all mammalian phosphatidylinositol 3-kinase-related protein kinases (PIKKs) depends on their interaction with Tel2, the ortholog of yeast Tel2 and Caenorhabditis elegans Clk-2. Here we provide evidence that Tel2 acts with Hsp90 in the maturation of PIKK complexes. Quantitative immunoblotting showed that the abundance of Tel2 is low compared with the PIKKs, and Tel2 preferentially bound newly synthesized ATM, ATR, mTOR, and DNA-PKcs. Tel2 complexes contained, in addition to Tti1-Tti2, the Hsp90 chaperone, and inhibition of Hsp90 interfered with the interaction of Tel2 with the PIKKs. Analysis of in vivo labeled nascent protein complexes showed that Tel2 and Hsp90 mediate the formation of the mTOR TORC1 and TORC2 complexes and the association of ATR with ATRIP. The structure of yeast Tel2, reported here, shows that Tel2 consists of HEAT-like helical repeats that assemble into two separate {alpha}-solenoids. Through mutagenesis, we identify a surface patch of conserved residues involved in binding to the Tti1-Tti2 complex in vitro. In vivo, mutation of this conserved patch affects cell growth, levels of PIKKs, and ATM/ATR-mediated checkpoint signaling, highlighting the importance of Tti1-Tti2 binding to the function of Tel2. Taken together, our data suggest that the Tel2-Tti1-Tti2 complex is a PIKK-specific cochaperone for Hsp90.

Takai, Hiroyuki; Xie, Yihu; de Lange, Titia; Pavletich, Nikola P. (Rockefeller); (SKI)

2010-09-20T23:59:59.000Z

32

Discovery of 9-(6-aminopyridin-3-yl)-1-(3- (trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective and orally available mTOR inhibitor for treatment of cancer  

E-Print Network (OSTI)

The mTOR mediated PI3K/AKT/mTOR signal transduction pathway has been demonstrated to play a key role in a broad spectrum of cancers. Starting from the mTOR selective inhibitor 1 (Torin1), a focused medicinal chemistry ...

Kang, Seong A.

33

Integrated Dynamic Analysis of Floating Offshore Wind Turbines Bjrn Skaare*, Tor David Hanson*, Finn Gunnar Nielsen*, Rune Yttervik*, Anders Melchior Hansen**,  

E-Print Network (OSTI)

Integrated Dynamic Analysis of Floating Offshore Wind Turbines Bjørn Skaare*, Tor David Hanson of floating wind turbines exposed to forces from wind, waves and current has been developed for Hydro Oil & Energy's floating wind turbine concept, HYWIND. Two existing, independent, computer program systems

34

Molecular Characterization of High-Level-Cholera-Toxin-Producing El Tor Variant Vibrio cholerae Strains in the Zanzibar Archipelago of Tanzania  

Science Journals Connector (OSTI)

...lack of proper hygiene and sanitation infrastructure, especially in Africa and Asia. There...Network on Infectious Diseases (J-GRID) of the Ministry of Education, Culture...Kong RYC. 2008. Vibrio cholerae O1 hybrid El Tor strains, Asia and Africa. Emerg...

A. Naha; G. Chowdhury; J. Ghosh-Banerjee; M. Senoh; T. Takahashi; B. Ley; K. Thriemer; J. Deen; L. V. Seidlein; S. M. Ali; A. Khatib; T. Ramamurthy; R. K. Nandy; G. B. Nair; Y. Takeda; A. K. Mukhopadhyay

2013-01-16T23:59:59.000Z

35

Molecular Characterization of High-Level-Cholera-Toxin-Producing El Tor Variant Vibrio cholerae Strains in the Zanzibar Archipelago of Tanzania  

Science Journals Connector (OSTI)

...together with DNA sequence analysis data also confirmed our initial MAMA...Analysis of these sequencing data revealed that there are neither...on Infectious Diseases (J-GRID) of the Ministry of Education...2008. Vibrio cholerae O1 hybrid El Tor strains, Asia and Africa...

A. Naha; G. Chowdhury; J. Ghosh-Banerjee; M. Senoh; T. Takahashi; B. Ley; K. Thriemer; J. Deen; L. V. Seidlein; S. M. Ali; A. Khatib; T. Ramamurthy; R. K. Nandy; G. B. Nair; Y. Takeda; A. K. Mukhopadhyay

2013-01-16T23:59:59.000Z

36

Anti-Spin Control for Marine Propulsion Systems yvind N. Smogeli1, Jostein Hansen2, Asgeir J. Srensen1 and Tor Arne Johansen2  

E-Print Network (OSTI)

Anti-Spin Control for Marine Propulsion Systems �yvind N. Smogeli1, Jostein Hansen2, Asgeir J. Sørensen1 and Tor Arne Johansen2 Abstract-- An anti-spin controller for marine propulsion systems in rough the transients in the power system and reduce the mechanical wear and tear of the propulsion system components

Johansen, Tor Arne

37

Suppression of Feedback Loops Mediated by PI3K/mTOR Induces Multiple Overactivation of Compensatory Pathways: An Unintended Consequence Leading to Drug Resistance  

Science Journals Connector (OSTI)

...regulator of the cellular response to low energy, and it is activated when the ATP concentration...Feng Z , Levine AJ.The regulation of energy metabolism and the IGF-1/mTOR pathways...Zhang X, et alTSC2 integrates Wnt and energy signals via a coordinated phosphorylation...

Enrique Rozengurt; Heloisa P. Soares; and James Sinnet-Smith

2014-11-01T23:59:59.000Z

38

Abstract 4479: Influence of the blood-brain barrier on drug distribution and efficacy of PI3K/mTOR inhibitors  

Science Journals Connector (OSTI)

...Abstract 4479: Influence of the blood-brain barrier on drug distribution and efficacy...is influenced by the presence of blood-brain barrier (BBB). PI3K/mTOR/AKT is...with the former molecule optimized for brain delivery. Here the influence of the BBB...

Rajneet K. Oberoi; William F. Elmquist; Rajendar Mittapalli; Jenny Pokorny; Jann Sarkaria

2014-10-01T23:59:59.000Z

39

Current Biology, Vol. 14, 12961302, July 27, 2004, 2004 Elsevier Ltd. All rights reserved. DOI 10.1016/j.cub.2004.06.054 Rictor, a Novel Binding Partner of mTOR, Defines  

E-Print Network (OSTI)

1999), we used EST mining andMassachusetts Institute of Technology Nine Cambridge Center RT and, compared to mTOR, raptor, and G L, theMemorial-Sloan-Kettering Cancer Center 1275 York Avenue the mTOR effector S6K1 nor mycin regulate the activity of S6K1 and 4E-BP1 [1, 8­10]is it bound by FKBP12

Sabatini, David M.

40

RENATA REd NAcional Temtica de Astropartculas, Alcala, June 23 2009 Aldo Morselli, INFN Roma Tor Vergata 1 Multifrequency tests of Dark Matter  

E-Print Network (OSTI)

RENATA REd NAcional Temática de Astropartículas, Alcala, June 23 2009 Aldo Morselli, INFN Roma Tor WORKSHOP 2009, Silver Jubilee May 25-30, VulcanoRENATA REd NAcional Temática de Astropartículas , Alcala in the sky in the Fermi and Pamela era. June 23 2009 #12;RENATA REd NAcional Temática de Astropartículas

Morselli, Aldo

Note: This page contains sample records for the topic "admi nistra tor" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Dietary flavonoid fisetin: A novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management  

Science Journals Connector (OSTI)

Epidemiologic and case control population based studies over the past few decades have identified diet as an important determinant of cancer risk. This evidence has kindled interest into research on bioactive food components and has till date resulted in the identification of many compounds with cancer preventive and therapeutic potential. Among such compounds has been fisetin (3,7,3?,4?-tetrahydroxyflavone), a flavonol and a member of the flavonoid polyphenols that also include quercetin, myricetin and kaempferol. Fisetin is commonly found in many fruits and vegetables such as apples, persimmons, grapes, kiwis, strawberries, onions and cucumbers. We evaluated the effects of fisetin against melanoma and cancers of the prostate, pancreas and the lungs. Using prostate and lung adenocarcinoma cells, we demonstrated that fisetin acts as a dual inhibitor of the PI3K/Akt and the mTOR pathways. This is a significant finding considering the fact that mTOR is phosphorylated and its activation is more frequent in tumors with overexpression of PI3K/Akt. Dual inhibitors of PI3K/Akt and mTOR signaling have been suggested as valuable agents for treating such cancers. Here, we summarize our findings on the dietary flavonoid fisetin and its effects on cancer with particular focus on prostate cancer. Our observations and findings from other laboratories suggest that fisetin could be a useful chemotherapeutic agent that could be used either alone or as an adjuvant with conventional chemotherapeutic drugs for the management of prostate and other cancers.

Vaqar Mustafa Adhami; Deeba Nadeem Syed; Naghma Khan; Hasan Mukhtar

2012-01-01T23:59:59.000Z

42

Fisetin inhibits human melanoma cell growth through direct binding to p70S6K and mTOR: Findings from 3-D melanoma skin equivalents and computational modeling  

Science Journals Connector (OSTI)

Abstract The incidence of melanoma continues to rise. Inspite of treatment advances, the prognosis remains grim once the disease has metastasized, emphasizing the need to explore additional therapeutic strategies. One such approach is through the use of mechanism-based dietary intervention. We previously showed that the flavonoid fisetin inhibits melanoma cell proliferation, in vitro and in vivo. Here, we studied fisetin-mediated regulation of kinases involved in melanoma growth and progression. Time-course analysis in 3-D melanoma constructs that transitioned from radial to vertical growth showed that fisetin treatment resulted in significant decrease in melanocytic lesions in contrast to untreated controls that showed large tumor nests and invading disseminated cells. Further studies in melanoma cultures and mouse xenografts showed that fisetin-mediated growth inhibition was associated with dephosphorylation of AKT, mTOR and p70S6K proteins. In silico modeling indicated direct interaction of fisetin with mTOR and p70S6K with favorable free energy values. These findings were validated by cell-free competition assays that established binding of fisetin to p70S6K and mTOR while little affinity was detected with AKT. Kinase activity studies reflected similar trend with % inhibition observed for p70S6K and mTOR at lower doses than AKT. Our studies characterized, for the first time, the differential interactions of any botanical agent with kinases involved in melanoma growth and demonstrate that fisetin inhibits mTOR and p70S6K through direct binding while the observed inhibitory effect of fisetin on AKT is mediated indirectly, through targeting interrelated pathways.

Deeba N. Syed; Jean-Christopher Chamcheu; Mohammad Imran Khan; Mario Sechi; Rahul K. Lall; Vaqar M. Adhami; Hasan Mukhtar

2014-01-01T23:59:59.000Z

43

Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for the Treatment of Cancer  

E-Print Network (OSTI)

The mTOR protein is a master regulator of cell growth and proliferation, and inhibitors of its kinase activity have the potential to become new class of anticancer drugs. Starting from quinoline 1, which was identified in ...

Liu, Qingsong

44

Rsultats des candidatures au Diplme de l'ENS Jury du 7 juillet 2011 -Dpartements scientifiques  

E-Print Network (OSTI)

-LEDUC Bertrand Admis M1 VON WOLFF Niklas Admis M1 WANG Pengcheng Admis M1 #12;3 / 3 Département de géosciences

45

mTOR/p70S6K signaling distinguishes routine, maintenance-level autophagy from autophagic cell death during influenza A infection  

Science Journals Connector (OSTI)

Abstract Autophagy, a stress response activated in influenza A virus infection helps the cell avoid apoptosis. However, in the absence of apoptosis infected cells undergo vastly expanded autophagy and nevertheless die in the presence of necrostatin but not of autophagy inhibitors. Combinations of inhibitors indicate that the controls of protective and lethal autophagy are different. Infection that triggers apoptosis also triggers canonical autophagy signaling exhibiting transient PI3K and mTORC1 activity. In terminal autophagy phospho-mTOR(Ser2448) is suppressed while mTORC1, PI3K and mTORC2 activities increase. mTORC1 substrate p70S6K becomes highly phosphorylated while its activity, now regulated by mTORC2, is required for LC3-II formation. Inhibition of mTORC2/p70S6K, unlike that of PI3K/mTORC1, blocks expanded autophagy in the absence of apoptosis but not moderate autophagy. Inhibitors of expanded autophagy limit virus reproduction. Thus expanded, lethal autophagy is activated by a signaling mechanism different from autophagy that helps cells survive toxic or stressful episodes.

Emmanuel Datan; Alireza Shirazian; Shawna Benjamin; Demetrius Matassov; Antonella Tinari; Walter Malorni; Richard A. Lockshin; Adolfo Garcia-Sastre; Zahra Zakeri

2014-01-01T23:59:59.000Z

46

Programme examen 16 mai 2011 Analyse L1 IMM Duree 3 heures Aucun document n'est admis, calculatrices et telephones interdits  

E-Print Network (OSTI)

*************************************************************** Chapitre 1. Rappels Chapitre 2. Fonctions continues Chapitre 3. D´erivation Chapitre 4. Th´eor`emes des´efinition 1.8 (limite de suite) *Th´eor`eme 1.3 (convergence des suites monotones) *Th´eor`eme 1.4 (Bolzano-Weierstrass) Chapitre 2 (continuit´e) ----------------- *Th´eor`eme 2.1 (Weierstrass)) *Th´eor`eme 2.2 (valeurs interm

Vignal, Marie-Hélène

47

Protection of an endangered fish Tor tor and Tor putitora population impacted by transportation network in the area of Tehri Dam Project, Garhwal Himalaya, India  

E-Print Network (OSTI)

Proceedings Making Connections b. Choking of Breeding Grounds and Migration Channels Environmental degradation,

Sharma, Ramesh C.

2003-01-01T23:59:59.000Z

48

Glucose–TOR signalling reprograms the transcriptome and activates meristems  

Science Journals Connector (OSTI)

... Ramon for critical reading of the manuscript. Y.X. is supported by the MGH Tosteson Postdoctoral Fellowship. C.X. is supported by Chinese Academy of Sciences (KSCX3-YW- ...

Yan Xiong; Matthew McCormack; Lei Li; Qi Hall; Chengbin Xiang; Jen Sheen

2013-03-31T23:59:59.000Z

49

Energy Information Administration / Annual Energy Outlook 2011  

Annual Energy Outlook 2012 (EIA)

Fede ral Highwa y Admi nistration, Highway Statistics 2008 (Washington, DC, April 2010); Oak Ridge N ational Labo ratory, Transportation Energy Data Book: Edition 29 and Annual...

50

Supersensitive?-adrenergic receptors are down-regulated in rat brain by mianserin administration  

Science Journals Connector (OSTI)

Experiments were undertaken to determine whether alterations in rat brain monoaminergic tone influence the manner in which mianserin administration modifies?-adrenergic receptor function. Whereas the chronic admi...

A. Pilc; S. J. Enna

1987-01-01T23:59:59.000Z

51

mTOR Signaling Regulates Nucleolar Targeting of the SUMO-Specific Isopeptidase SENP3  

Science Journals Connector (OSTI)

...A central question is how changes in energy supply feed into the regulation of ribosome...maturation in response to the cellular energy status. INTRODUCTION Ribosomes are large...biogenesis must be tightly coupled to the energy status and nutrient levels of the cell...

Nithya Raman; Arnab Nayak; Stefan Muller

2014-10-06T23:59:59.000Z

52

Norm estimates of complex symmetric opera-tors applied to quantum systems  

E-Print Network (OSTI)

for computing the norm of a compact complex symmetric operator. This ob- servation is applied to two concrete symmetric operator [10]. For certain unbounded operators with compact resolvent, the refined polar with non-selfadjoint operators is much more difficult than with self- adjoint operators due to the lack

53

Sex dierences in the emotional brain Tor D. WagerCA  

E-Print Network (OSTI)

Williams & Wilkins. INTRODUCTION Since the times of the Greek philosophers, and probably before, humankind evolved to process emotional stimuli. How- ever, measurements of brain function measure the end products

Ochsner, Kevin

54

PTEN Deficiency Mediates a Reciprocal Response to IGFI and mTOR Inhibition  

Science Journals Connector (OSTI)

...Technologies) were cultured in Vasculife Basal Media (Lifeline Technologies) supplemented...6 mug/mL) for 3 hours, after which media were changed and the cells split for proliferation...IGFI, cells were kept in serum-free media for two hours in combination with the IGFI...

Mukund Patel; Nicholas C. Gomez; Andrew W. McFadden; Billie M. Moats-Staats; Sam Wu; Andres Rojas; Travis Sapp; Jeremy M. Simon; Scott V. Smith; Kathleen Kaiser-Rogers; Ian J. Davis

2014-11-01T23:59:59.000Z

55

A Conceptual Framework for Semantic Case-based Safety Analysis Olawande Daramola, Tor Stlhane  

E-Print Network (OSTI)

.biffl}@tuwien.ac.at Abstract Hazard and Operability (HAZOP) Analysis and Fail- ure Mode and Effect Analysis (FMEA) are among-based framework for safety analy- sis, which facilitates the reuse of previous HAZOP and FMEA experiences in order application. Key words: Safety analysis, HAZOP, FMEA, ontology, requirements, case-based reasoning, natural

56

Normal Function of the Yeast TOR Pathway Requires the Type 2C Protein Phosphatase Ptc1  

Science Journals Connector (OSTI)

...define the major K transport system in fission yeast. J. Bacteriol...10 Chen, J. C., and T. Powers. 2006. Coordinate regulation...C. Y. Chen, and T. Powers. 2002. Mks1 in concert with...Bradshaw and E. Dennis (ed.), Handbook of cell signaling, vol. 1...

Asier González; Amparo Ruiz; Antonio Casamayor; Joaquín Ariño

2009-03-09T23:59:59.000Z

57

VANISHING OF EXT AND TOR OVER SOME COHEN-MACAULAY LOCAL RINGS  

E-Print Network (OSTI)

versions of conjectures of Auslander-Reiten and Tachikawa. Introduction In recent years, there has been

Sega, Liana - Department of Mathematics and Statistics, University of Missouri

58

Dynamics and Control of a Free-Piston Diesel Engine Tor A. Johansen1  

E-Print Network (OSTI)

and Technology, N-7491 Trondheim, Norway. ££ Kværner ASA, Technology Development Postboks 169, N-1325 Lysaker and to use a power turbine instead to convert energy from the exhaust gas. In addition, the camshaft and compactness of gas turbines with the low fuel consumption of diesel engines. This was the motivation 1

Johansen, Tor Arne

60

Anexo A: Artculo 57, "Proyecto de reglamento para seguridad y calidad de servicio, y servicios complementarios" CNE. Diciembre 2005  

E-Print Network (OSTI)

sistema. Anexo D: Mercados Internacionales 1. Brasil 1.1 Introducción En Brasil, la Agencia Nacional de funcionamiento del mercado de SS.CC en Brasil. Figura Nº 1: Admi

Rudnick, Hugh

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61

Insulin abuse  

Science Journals Connector (OSTI)

A 4-month-old infant and a 1-week-old neonate [sex not stated] developed hypoglycaemia [times to reaction onset not stated] after suspected surreptitious insulin administration [outcomes not stated]. Insulin admi...

2007-06-01T23:59:59.000Z

62

Deadheads and Propeller Heads  

Science Journals Connector (OSTI)

These young researchers were not just rebelling for the sake of it, they were exploring different ways of working, collaborating and innovating. LSD wasn’t even then considered a recreational drug. It was admi...

Assoc. Prof. Ian Watson

2012-01-01T23:59:59.000Z

63

Appropriation des objets TIC pour la perte d'autonomie Rsum court  

E-Print Network (OSTI)

Appropriation des objets TIC pour la perte d'autonomie Résumé court Il est maintenant largement admis que les objets TIC destinés aux personnes en perte d'autonomie ne répondent pas aux services-vivre de la personne. Résumé étendu Il est maintenant largement admis que les objets TIC destinés aux

Boyer, Edmond

64

11241. Proposed by Roberto Tauraso, Universit`a di Roma "Tor Vergata", Rome, Italy. Find a closed formula for  

E-Print Network (OSTI)

are well known; it turns out that M = Fm (the mth Fibonacci number) and N = Lm (the mth Lucas number (-2)n ; (b) if = -1 + Lm 5 , where m is an odd integer, then F,odd(n) = (6 - Lm - 5Fm)(-2 - 3Lm + 5Fm) 20Fm(Lm + 4) · 2(Lm - 1)(Lm + 4) 5(2 + 3Lm + 5Fm) n + (6 - Lm + 5Fm)(2 + 3Lm + 5Fm) 20Fm(Lm + 4) · 2

Heckman, Christopher Carl

65

Picking the Point of Inhibition: A Comparative Review of PI3K/AKT/mTOR Pathway Inhibitors  

Science Journals Connector (OSTI)

...Josep Tabernero 1 Corresponding Author: Rodrigo Dienstmann, Molecular Therapeutics Research...Fax: 349-3274-6059; E-mail: rodrigo.dienstmann@sagebase.org Authors...Lucas J, Chaudhary I, Dehnhardt C, Santos ED, et alAntitumor efficacy of PKI-587...

Rodrigo Dienstmann; Jordi Rodon; Violeta Serra; and Josep Tabernero

2014-05-01T23:59:59.000Z

66

Effect of isoflavones alone and in combination with rapamycin on mTOR pathway in human glioblastoma cells (U87).  

Science Journals Connector (OSTI)

...Our aim was to determine the effect of isoflavones such as genistein...these isoflavones exerted little effect on S6K, 4EBP1, and EIF4E proteins...more sensitive to rapamycin effect whereas others are more resistant...Student Research and Scholar ship Committee (GSRSC) grant at...

Shilpa Puli; Eric Nielson; James C K Lai; and Alok Bhushan

2006-04-15T23:59:59.000Z

67

Survival Signaling by Notch1: Mammalian Target of Rapamycin (mTOR)–Dependent Inhibition of p53  

Science Journals Connector (OSTI)

...Technology (Fund for Improvement of Science and Technology Infrastructure in Universities and Higher Educational Institutions), and...erythroleukemia cells and is necessary for differentiation induced by hybrid polar compounds. J Cell Biochem 1999;73:164-5. 32...

Sathish Kumar Mungamuri; XiaoHe Yang; Ann D. Thor; and Kumaravel Somasundaram

2006-05-01T23:59:59.000Z

68

Abstract 612: Fisetin, a dietary flavonoid and novel mTOR inhibitor for treatment and prevention of prostate cancer  

Science Journals Connector (OSTI)

...Apr 12-16, 2008; San Diego, CA Fisetin, a novel dietary flavonoid causes apoptosis...attractive target for chemoprevention. Fisetin (3,3',4',7-tetrahydroxyflavone...this study was to determine the effect of fisetin on cell-growth and apoptosis in human...

Vaqar M. Adhami; Rahul K. Lall; Hasan Mukhtar

2012-04-15T23:59:59.000Z

69

EXPERIMENT GUIDE SUP E R CON D U C TOR DE M ON S T RA T ION S  

E-Print Network (OSTI)

superconductors Colorado Superconductor, Inc's growing family of High Temperature Superconductor Kits emphasize are these superconductors made? Taking care of your superconductor The Kelvin scale of temperature The measurement several Comparison Kits that compare the properties of some of the leading high temperature

Bayindir, Mehmet

70

Abstract C200: Rapid nano-immunoassay for evaluation of mTOR pathway activation in acute myeloid leukemia.  

Science Journals Connector (OSTI)

...Oct 22-26, 2007; San Francisco, CA A nano-immunoassay system for monitoring changes...tumor regression. Now, using a novel nano-immunoassay system (FireflyTM instrument...hematopoietic tumor cells. We used the nano-immunoassay system to measure changes...

Himalee Sabnis; Heath Bradley; Todd Cooper; Kevin Bunting

2013-11-01T23:59:59.000Z

71

Energy Balance, the PI3K-AKT-mTOR Pathway Genes, and the Risk of Bladder Cancer  

Science Journals Connector (OSTI)

...subgroups as defined energy balance status. Compared with...intake and smoking status. Energy balance reflects...physical activity, energy balance, and cancer...socioeconomic status, and risks of...bladder cancer in US men and women...

Jie Lin; Jianming Wang; Anthony J. Greisinger; H. Barton Grossman; Michele R. Forman; Colin P. Dinney; Ernest T. Hawk; and Xifeng Wu

2010-04-01T23:59:59.000Z

72

Acquisition of classical CTX prophage from Vibrio cholerae O141 by El Tor strains aided by lytic  

E-Print Network (OSTI)

and poor sanitation (1, 2). Seven distinct pandemics of cholera have been recorded since the first pandemic

Mekalanos, John

73

An Asymmetry-to-Symmetry Switch in Signal Transmission by the Histidine Kinase Receptor for TMAO  

SciTech Connect

The osmoregulator trimethylamine-N-oxide (TMAO), commonplace in aquatic organisms, is used as the terminal electron acceptor for respiration in many bacterial species. The TMAO reductase (Tor) pathway for respiratory catalysis is controlled by a receptor system that comprises the TMAO-binding protein TorT, the sensor histidine kinase TorS, and the response regulator TorR. Here we study the TorS/TorT sensor system to gain mechanistic insight into signaling by histidine kinase receptors. We determined crystal structures for complexes of TorS sensor domains with apo TorT and with TorT (TMAO); we characterized TorS sensor associations with TorT in solution; we analyzed the thermodynamics of TMAO binding to TorT-TorS complexes; and we analyzed in vivo responses to TMAO through the TorT/TorS/TorR system to test structure-inspired hypotheses. TorS-TorT(apo) is an asymmetric 2:2 complex that binds TMAO with negative cooperativity to form a symmetric active kinase.

Moore, Jason O.; Hendrickson, Wayne A. (Columbia)

2012-06-28T23:59:59.000Z

74

Phase I Study of the Antiangiogenic Antibody Bevacizumab and the mTOR/Hypoxia-Inducible Factor Inhibitor Temsirolimus Combined with Liposomal Doxorubicin: Tolerance and Biological Activity  

Science Journals Connector (OSTI)

...of 14 patients will have 82% power to detect effects sizes of 0...of grade 2 or higher hand-foot syndrome, mucositis, thrombocytopenia...neutropenia (n = 6, 14%), hand-foot syndrome (n = 5, 12...thrombocytopenia, mucositis, hand-foot syndrome, hypertension, and...

John Moroney; Siqing Fu; Stacy Moulder; Gerald Falchook; Thorunn Helgason; Charles Levenback; David Hong; Aung Naing; Jennifer Wheler; and Razelle Kurzrock

2012-10-15T23:59:59.000Z

75

GDC-0980 Is a Novel Class I PI3K/mTOR Kinase Inhibitor with Robust Activity in Cancer Models Driven by the PI3K Pathway  

Science Journals Connector (OSTI)

...platelet-derived MHC class I Next, we utilized...coating by platelets in greater detail. Resting platelets...levels of CD41a and MHC class I, whereas only negligible...could be restored in great part by blocking MHC class I (Fig. 4A). Of...

Jeffrey J. Wallin; Kyle A. Edgar; Jane Guan; Megan Berry; Wei Wei Prior; Leslie Lee; John D. Lesnick; Cristina Lewis; Jim Nonomiya; Jodie Pang; Laurent Salphati; Alan G. Olivero; Daniel P. Sutherlin; Carol O'Brien; Jill M. Spoerke; Sonal Patel; Letitia Lensun; Robert Kassees; Leanne Ross; Mark R. Lackner; Deepak Sampath; Marcia Belvin; and Lori S. Friedman

2011-12-01T23:59:59.000Z

76

Suppression of Feedback Loops Mediated by PI3K/mTOR Induces Multiple Overactivation of Compensatory Pathways: An Unintended Consequence Leading to Drug Resistance  

Science Journals Connector (OSTI)

...cell types (67). At low concentrations of metformin, the inhibitory effect on mTORC1 is prominent in cells incubated in medium containing physiologic concentrations of glucose (68). Studies in vitro demonstrated that AMPK inhibits mTORC1 activation...

Enrique Rozengurt; Heloisa P. Soares; James Sinnet-Smith

2014-11-01T23:59:59.000Z

77

Abstract 1586: Tumor regression in a 3-D melanoma model by the dietary flavonoid fisetin is associated with inhibition of Akt/mTOR signaling  

Science Journals Connector (OSTI)

...CAD phosphorylation and is inhibited by fisetin Mohammad Imran Khan 1 Vaqar Mustafa Adhami...also tested the potential efficacy of fisetin, an agent which we previously established...phosphorylation we tested the efficacy of fisetin to inhibit CAD phosphorylation at Ser1859...

Deeba N. Syed; Vaqar M. Adhami; Jean Christopher Chamcheu; Rahul K. Lall; Hasan Mukhtar

2012-04-15T23:59:59.000Z

78

Phase I Study of the Antiangiogenic Antibody Bevacizumab and the mTOR/Hypoxia-Inducible Factor Inhibitor Temsirolimus Combined with Liposomal Doxorubicin: Tolerance and Biological Activity  

Science Journals Connector (OSTI)

...Department of Investigational Cancer Therapeutics at MD Anderson Cancer Center for editing our manuscript. References 1. Rademakers SE , Span PN, Kaanders JH, Sweep FC, van der Kogel AJ Bussink J.Molecular aspects of tumour hypoxia.Mol Oncol 2008...

John Moroney; Siqing Fu; Stacy Moulder; Gerald Falchook; Thorunn Helgason; Charles Levenback; David Hong; Aung Naing; Jennifer Wheler; Razelle Kurzrock

2012-10-15T23:59:59.000Z

79

The rapid progress of nanoscale science and technology challenges the optoelectronics community to develop ever smaller lasers and other optoelectronic devices compatible with  

E-Print Network (OSTI)

The miniaturization of optoelectronic devices such as light emitting diodes or semiconduc- tor lasers, is expected

Wu, Shin-Tson

80

1 INTRODUCTION Evaluating safety instrumented systems [SIS] reliabil-  

E-Print Network (OSTI)

offshore, military, or nuclear power plant activities. However, the influencing fac- tors of many systems

Paris-Sud XI, Université de

Note: This page contains sample records for the topic "admi nistra tor" from the National Library of EnergyBeta (NLEBeta).
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We encourage you to perform a real-time search of NLEBeta
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81

Pharmacokinetics of tobramycin and gentamicin in abusers of intravenous drugs.  

Science Journals Connector (OSTI)

...Median duration (days) of 7 (1-100) 5 (1-100) 26 (5-60) symptoms before admis- sion (range) Reported drug usec Heroin 9 (50) 4 (33) 5 (83) Pentazocine-pyribenzamine 8 (44) 5 (42) 3 (50) ("T's and blues") Meperidine 5...

C H King; R J Creger; J J Ellner

1985-03-01T23:59:59.000Z

82

Essai de modlisation du progrs technique endogne Quels enseignements sur l'apport futur des TIC la croissance conomique ?  

E-Print Network (OSTI)

Essai de modélisation du progrès technique endogène Quels enseignements sur l'apport futur des TIC enseignements sur l'apport futur des TIC à la croissance économique ? Introduction La diffusion des produits tic vigoureux dans l'industrie des produits tic ? Il est tentant de retrouver les faits largement admis et

Boyer, Edmond

83

FY2010 AnnuAl RepoRt eDA university Center program  

E-Print Network (OSTI)

..................................................................................................... 15 3.1.3. Economic Assessment Process.S. Department of Commerce Economic Development Administration EDA Grant No. 05-66-05033 #12;2 Abstract ThiS ANNUAl REPoRT of ThE ECoNomiC DEvEloPmENT ADmiNiSTRATioN-UNivERSiTy CENTER (EDA-UC) PRoGRAm PRovi

Vaswani, Namrata

84

Candidature une admission en 2nde Elves-ingnieurs IFMA, ISIMA ou  

E-Print Network (OSTI)

Candidature à une admission en 2nde année Elèves-ingénieurs IFMA, ISIMA ou Polytech principe pour l'admission en 2nde année du Master recherche. La liste définitive des admis sera arrêtée en

Sart, Remi

85

Philosophische Fakultt I Erste nderung  

E-Print Network (OSTI)

College Dublin, Universität Rom ,,Tre", Universität Rom ,,Tor Vergata" sowie assoziierte Mitglieder (King's College London, University College Dublin, Universität Rom ,,Tre", Universität Rom ,,Tor Vergata

Röder, Beate

86

Development of Thermotolerance in a Human Melanoma Xenograft  

Science Journals Connector (OSTI)

...the Nansen Scientific Fund. Einar K. Rofstad 2 Tor Brustad Norsk Hydro's Institute for Cancer Research and the Norwegian Cancer...Human Melanoma Xenograft1 Einar K. Rofstad2 and Tor Brustad Norsk Hydro's Institute tor Cancer Research and the Norwegian Cancer...

Einar K. Rofstad and Tor Brustad

1984-02-01T23:59:59.000Z

87

An Overview of Anonymity Technology Usage Bingdong Lia  

E-Print Network (OSTI)

networks significantly more than others. Moreover, our application analysis reveals that Tor and proxy routing; Tor Corresponding Author: mgunes@cse.unr.edu, Tel: +1 (775) 784 - 4313, Fax: +1 (775) 784 1877 source anonymity tools. Community contributed systems include the Java Anon Proxy (JAP) [11], Tor [20

Gunes, Mehmet Hadi

88

Dietary flavonoid fisetin induces apoptosis, down regulates COX2 and suppresses Wnt signaling pathway in HT29 colon cancer cells  

Science Journals Connector (OSTI)

...31-Apr 4, 2012; Chicago, IL Abstract 612: Fisetin, a dietary flavonoid and novel mTOR inhibitor...mTOR receptor and in silico studies showed that fisetin physically interacts with mTOR. Fisetin is a tetrahydroxyflavone, found in strawberry...

Yewseok Suh and Hasan Mukhtar

2008-05-01T23:59:59.000Z

89

Abstract 3831: The dietary flavonoid fisetin negatively regulates NEDD9 expression and inhibits melanoma progression: studies in monolayer and 3D melanoma skin equivalent cultures.  

Science Journals Connector (OSTI)

...31-Apr 4, 2012; Chicago, IL Abstract 612: Fisetin, a dietary flavonoid and novel mTOR inhibitor...mTOR receptor and in silico studies showed that fisetin physically interacts with mTOR. Fisetin is a tetrahydroxyflavone, found in strawberry...

Deeba N. Syed; Jean-Christopher Chamcheu; Rahul K. Lall; Annika Selvick; Karilynn Zwirchitz; Hasan Mukhtar

2013-04-15T23:59:59.000Z

90

La construction de quelques comptences TIC 1 Batrice Drot-Delange et al. La construction de quelques comptences TIC au cours de la seconde anne  

E-Print Network (OSTI)

La construction de quelques compétences TIC 1 Béatrice Drot-Delange et al. La construction de quelques compétences TIC au cours de la seconde année d'IUFM. Analyse de deux cas Béatrice Drot formation des maîtres, notamment dans le domaine des TIC. Il est en effet généralement admis dans ce domaine

Paris-Sud XI, Université de

91

Abstract 5554: PBI-05204, a supercritical CO2 extract of Nerium oleander, inhibits the growth of human pancreatic cancer in a Panc-1 orthotopic model by down-regulation of PI3k/mTOR pathways.  

Science Journals Connector (OSTI)

...Abstract 5554: PBI-05204, a supercritical CO2 extract of Nerium oleander, inhibits the...botanical drug PBI-05204, a supercritical CO2 extract of Nerium oleander, was examined...Peiying Yang. PBI-05204, a supercritical CO2 extract of Nerium oleander, inhibits the...

Yong Pan; Sun-Jin Kim; Patrea Rhea; Carrie Cartwright; Ho Jeong Lee; Crandell Addington; Mihai Gagea; Robert A. Newman; Peiying Yang

2013-08-14T23:59:59.000Z

92

Abstract #2302: NVP-BEZ235 a dual inhibitor of phosphatidylinositol 3-Kinase (PI3 Kinase) and mammalian target of rapamycin (mTOR) potently enhances the effects of ionizing radiation.  

Science Journals Connector (OSTI)

...ionizing radiation. Benjamin...effects of ionizing radiation in vitro...BEZ235 at doses of 50 nM...radiation dose range from 0-8...NVP-BEZ235 doses of 1microM...damage after radiation.-H2AX...effect of ionizing radiation in a range of epithelial...

Benjamin Solomon; Anthony Natoli; Jim Hagekyriakou; Carleen Cullinane; and Grant McArthur

2009-05-01T23:59:59.000Z

93

Raf functions downstream of Rasl in the Sevenless signal transduction pathway  

Science Journals Connector (OSTI)

... of the indicated construct. Flies homozygous for the sE-raf tor construct display a severe roughening of the eye, comparable to that observed in heterozygotes for the sE-raf tor4021 ... comparable to that observed in heterozygotes for the sE-raf tor4021 construct (d}. This roughening correlates with an increase in the number of additional R7-like cells (data not ...

Barry Dickson; Frank Sprenger; Deborah Morrison; Ernst Hafen

1992-12-10T23:59:59.000Z

94

E-Print Network 3.0 - adenoviral oncoprotein e1b55k Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

Neurobiology Lab, Salk Institute for Biological Studies Collection: Biology and Medicine 10 Adenoviral proteins mimic nutrientgrowth signals to activate the mTOR pathway for viral...

95

BELANGER, T. V., AND M. T. MONTGOMERY. Seepage meter errors  

Science Journals Connector (OSTI)

tor is applied, field test “point estimates” of seep- ..... Location, depth, and mean seepage rate for each meter in a transect across Indian River lagoon near.

2000-03-19T23:59:59.000Z

96

E-Print Network 3.0 - autophagy cytokines drugs Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

Cell Death Society Symposium Summary: of autophagy in mammals: the role of Ambra1 Mauro Piacentini: Univ. Di Roma Tor Vergata & Hop. Spallanzani... Grenoble, France 12:30 -...

97

InThisIssue Advanced Study  

E-Print Network (OSTI)

displays, consumer electronics, automotive lighting, traffic signals, and general illumination." "Millions invented the transis- tor. An early researcher in semiconductor electronics, Holonyak gained eminence

Lewis, Jennifer

98

E-Print Network 3.0 - aeroelastic code hawc Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

Databases and Resources 4 Integrated Dynamic Analysis of Floating Offshore Wind Turbines Bjrn Skaare*, Tor David Hanson*, Finn Gunnar Nielsen*, Rune Yttervik*, Anders...

99

Assessing the operations of the bulk oil storage and Transportation Company Limited in petroleum products delivery to Northern Ghana.  

E-Print Network (OSTI)

??The government of Ghana realising the importance of petroleum products, established the Tema Oil Refinery (TOR) in 1961 in order to process crude oil into… (more)

Moses Oswald Avoyingah Amoah

2011-01-01T23:59:59.000Z

100

E-Print Network 3.0 - anti pp interactions Sample Search Results  

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Collection: Computer Technologies and Information Sciences 51 Anti-Spin Control for Marine Propulsion Systems yvind N. Smogeli1, Jostein Hansen2, Asgeir J. Srensen1 and Tor...

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101

Part 1 of 11  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Nati onal Renewable Energy Laboratory Division (hereinafter called NREL), and Evergreen Solar, Inc, (hereinafter called "Subcontrac tor") whose principal offices are located in...

102

E-Print Network 3.0 - amplitude insult project Sample Search...  

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Biology and Medicine 2 Original Paper Pathobiology 2005;72:171178 Summary: and acrolein in ischemic insults. The exploration of these fac- tors will likely help us design...

103

spectrum30m.eps  

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8 X-band RF driven FEL Driver with Optics Linearization Yipeng Sun SLAC National Accelerator Laboratory, Menlo Park, California 94025, USA Paul Emma, Tor Raubenheimer and...

104

E-Print Network 3.0 - artemether artesunate oz78 Sample Search...  

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elimination fac- tors (Souares, unpublished data). The same conclusion was reported in Uganda with artemether... AQSP were separated, the ACT, at least for the two main...

105

The Solar Chimney  

E-Print Network (OSTI)

Hot air for the solar chimney is produced by the greenhouse effect in a simple air collec- tor consisting only of a glass or plastic film covering stretched ...

scul

2002-11-27T23:59:59.000Z

106

E-Print Network 3.0 - aldo menzione angelo Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

Vergata, aldo.morselli@roma2.infn.it 1 From Quantum to Emergent Gravity: Theory and Phenomenology Summary: Aldo Morselli, INFN & Universit di Roma Tor Vergata,...

107

E-Print Network 3.0 - activating factor-stimulated human Sample...  

NLE Websites -- All DOE Office Websites (Extended Search)

factor mediated activation of mTOR is deregulated in human cancer... , Schaffhausen B, Pallas DC, White M, Cantley L, Roberts TM. Common elements in growth factor stimulation... ,...

108

Heat Sensitivity and Thermotolerance in Cells from Five Human Melanoma Xenografts  

Science Journals Connector (OSTI)

...Scientific Fund. Einar K. Rofstad 2 Hilde Midthjell Tor Brustad Norsk Hydro's Institute for Cancer Research and the Norwegian Cancer...Xenografts1 Einar K. Rofstad,2 Hilde Midthjell, and Tor Brustad Norsk Hydro's Institute for Cancer Research and the Norwegian Cancer...

Einar K. Rofstad; Hilde Midthjell; Tor Brustad

1984-10-01T23:59:59.000Z

109

Ability of Inhibitors of Glycosylation and Protein Synthesis to Sensitize Cells to Abrin, Ricin, Shigella Toxin, and Pseudomonas Toxin  

Science Journals Connector (OSTI)

...Pseudomonas Toxin Kirsten Sandvig Tor Inge Tonnessen Sjur Olsnes Norsk Hydro's Institute for Cancer Research and The Norwegian Cancer...Toxin Kirsten Sandvig, Tor Inge T0nnessen, and Sjur Olsnes Norsk Hydro's Institute for Cancer Research and The Norwegian Cancer...

Kirsten Sandvig; Tor Inge Tønnessen; Sjur Olsnes

1986-12-01T23:59:59.000Z

110

http://w3.pppl.gov/zakharov ZinkleNelson  

E-Print Network (OSTI)

Coils He atmosphere TFC I B tor Li stream Li stream V First wall Plasma FLiBe channel 500 o C 800 o C Coil Lithium jets between TF Coils He atmosphere TFC I B tor Li stream Li stream V First wall Plasma for a tokamak­reactor Leonid E. Zakharov, Princeton University , Princeton Plasma Physics Laboratory Presented

Zakharov, Leonid E.

111

Beclin1-induced Autophagy Abrogates Radioresistance of Lung Cancer Cells by Suppressing Osteopontin  

Science Journals Connector (OSTI)

......all mammalian cell types by the mTOR inhibitor rapamycin.36) In this study, rapamycin...al (2008) Urocanic acid-modified chitosan-mediated PTEN delivery via aerosol...al (2008) Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy......

Seung-Hee Chang; Arash Minai-Tehrani; Ji-Young Shin; Sungjin Park; Ji-Eun Kim; Kyeong-Nam Yu; Seong-Ho Hong; Choong-Man Hong; Kee-Ho Lee; George R Beck; Jr; Myung-Haing Cho

2012-05-01T23:59:59.000Z

112

Proceedings of the 2002 IEEE International Conference on Robotics& Automation  

E-Print Network (OSTI)

material based actua- tors to power the robot joints [l]. Smart materials alter some aspect and polymers are examples of smart materials. The interest in these types of actuatorsevolved from the prom one of the highest pay- load to weight ratios among "smart material'' based actua- tors. Therefore

Mavroidis, Constantinos

113

Anomalous electron-ion energy coupling in electron drift wave turbulence  

E-Print Network (OSTI)

transport: new aspects for nuclear fusion reac- tor design,BRAAMS and P.E. STOTT, Nuclear Fusion: Half a Century ofto know something about nuclear fusion. Everything happened

Zhao, Lei

114

Testing standard and nonstandard neutrino physics with cosmological data Elena Giusarma,1  

E-Print Network (OSTI)

Laboratory, California Institute of Technology, Pasadena, California 91109, USA 3 California Institute of Technology, Pasadena, California 91125, USA (Received 26 November 2012; published 7 February 2013, solar, atmospheric, reactor, and accelera- tor neutrinos have provided compelling evidence

Adolphs, Ralph

115

results of Parigi et al., the laboratory tech-niques they describe could pave the way  

E-Print Network (OSTI)

results of Parigi et al., the laboratory tech- niques they describe could pave the way toward new and momentum are obtained by applying "opera- tors" to a system's wave function. 3. V. Parigi, A. Zavatta, M

Keeling, Patrick

116

WEATHER, p. 2 Volume 134, Number 35 Friday, September 5, 2014  

E-Print Network (OSTI)

@tech.mit.edu. MIT Medical confirms no Ebola cases on campus In light of the ongoing Eb- ola outbreak, MIT Medical in- dividual at risk for Ebola contact health officials, who may moni- tor their health until

117

Microcircuits for Night Vision in Mouse Retina Yoshihiko Tsukamoto,1 Katsuko Morigiwa,2 Mika Ueda,1 and Peter Sterling3  

E-Print Network (OSTI)

glutamate receptors (Hack et al., 1999, 2001). We show that this rod­cone bipolar cell sends an axon from rods to processes that express ionotropic glutamate recep- tors (iGluRs) (Hack et al., 1999, 2001

Pennsylvania, University of

118

Remarkable Sounds  

Science Journals Connector (OSTI)

... croyet que les âmes des hommes sont la tor-mentees de froid."("La Cosmographie universelle,"Basle, 1552, p. 1051.) Against this error Arngrimus lonas writes, but ...

KUMAGUSU MINAKATA

1896-02-06T23:59:59.000Z

119

Select Nutrients, Secreted Phosphoprotein 1 and Insulin-Like Growth Factor 2: Effects of Trophectoderm of Ovine Conceptuses  

E-Print Network (OSTI)

of pregnancy. Among them, several components of histotroph including nutrients, cell matrix proteins and growth factors may activate mTOR (mammalian target of rapamycin; also known as FRAP1) to stimulate hypertrophy, hyperplasia, and/or migration of conceptus...

Kim, Jin Young

2011-08-08T23:59:59.000Z

120

Cenozoic continental deposits of New Mexico: An overview  

Science Journals Connector (OSTI)

...of the region from Socorro and San Antonio east to Chupadera Mesa, Socorro County, New Mexico: U.S. Geological...of Joyita Hills, Los Pinos Mountains and northern Chupadera Mesa, Valencia, Tor- rance and Socorro Counties, New...

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121

The Eocene biostratigraphy of New Mexico  

Science Journals Connector (OSTI)

...of Joyita Hills, Los Pinos Mountains and northern Chupadera Mesa, Valencia, Tor- rance and Socorro Counties, New...of the region from Socorro and San Antonio east to Chupadera Mesa, Socorro County, New Mexico: U.S. Geological...

122

CORRELATION OF THE PERMIAN FORMATIONS OF NORTH AMERICA  

Science Journals Connector (OSTI)

...History of the Supai formation in Black Mesa, Yavapai County, Arizona: Plateau...Los Pinos Mountains, and northern Chupadera Mesa, Valencia, Tor- ranee, and Socorro...Cedar Hills ss., 77, 78, 79 Cedar Mesa ss., 52, 53, 54 Chase group...

123

A target for pharmacological intervention in an untreatable human disease  

Science Journals Connector (OSTI)

...acidosis, dyspnea, and characteristic progressive lesions of the brain stem, cerebellum, and basal ganglia. Encephalomyelopathy is...accumulation of metabolic intermediates in Ndufs4?/? brain. Furthermore, we found that mTOR signaling is hyperactivated...

Simon C. Johnson

2014-12-05T23:59:59.000Z

124

NUREG-0668 MASTER* TITLE LIST PUBLICLY AVAILABLE DOCUMENTS THREE...  

Office of Scientific and Technical Information (OSTI)

FESS.O. OffIc. 770909 7pp ' 770B27 raquait for racontidaratlon of >19 3pp *rom M Jordan to iiacotlva Lag* I :tor 771130 3pp radiological affluan sasssra". '".:"(tm) 5...

125

WILD TURKEY REPRODUCTION IN APRAIRIE-WOODLAND COMPLEX  

E-Print Network (OSTI)

'l'entral South Dakol;l. Tht.' pattern of decimation and succcso;ful rco;tor;lIion in ,oulh· l"cntr:ll South

126

VERITY, PETER G., CHARLES Y. ROBERTSON, CRAIG R ...  

Science Journals Connector (OSTI)

the measuring grid, especially if the object is small ... on the sampling grid (i.e. computer moni- tor) and ..... breadth and depth of cells is further mini- mized by the ...

2000-03-19T23:59:59.000Z

127

Traffic Analysis Attacks and Defenses in Low Latency Anonymous Communication  

E-Print Network (OSTI)

Traffic Analysis Attacks and Defenses in Low Latency Anonymous Communication Sambuddho Chakravarty #12;ABSTRACT Traffic Analysis Attacks and Defenses in Low Latency Anonymous Communication Sambuddho the true network identity of com- municating parties against eavesdropping adversaries. Tor, acronym

Keromytis, Angelos D.

128

ACTIVE SHOOTER --ARMED INTRUDER RUN -Evacuate or flee if possible and safe. Have an escape plan. Consider all exits  

E-Print Network (OSTI)

spot. MEDICAL EMERGENCY � Contact 911. � Render first aid if trained. � Stay with the injured / ill lights. � Close blinds, block windows. � Turn off radios and computer moni- tors. � Keep occupants calm

129

Firenze University Press www.fupress.com/ah  

E-Print Network (OSTI)

, Salvador Carranza5 1 Dipartimento di Biologia, Università di Roma "Tor Vergata", Via della Ricerca, Barce- lona, Spain. E-mail: salvador.carranza@ibe.upf-csic.es Submitted on: 2010, 5th May; revised on

Carranza, Salvador

130

E-Print Network 3.0 - amiodarone Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

and Inhibition of the TOR Pathway4 Summary: for these genes in response to thymol (7), CaCl2, (31), rapamycin20 (16), amiodarone (32), nitrogen depletion... homeostasis in yeast2...

131

E-Print Network 3.0 - amiodarone destabilizes intracellular Sample...  

NLE Websites -- All DOE Office Websites (Extended Search)

and Inhibition of the TOR Pathway4 Summary: for these genes in response to thymol (7), CaCl2, (31), rapamycin20 (16), amiodarone (32), nitrogen depletion... homeostasis in yeast2...

132

Combustion Synthesis and Characterization of Nanocrystalline Tin and Tin Oxide (SnOx, x 02) Particles  

E-Print Network (OSTI)

Engineering, University of Michigan, Ann Arbor, Michigan 48109-2125 Nanocrystalline SnOx particles (x 0 solar cells,9 ­11 liquid crystal displays,10,11 photodetec- tors,6,11 and video touch screens,10 to name

Wooldridge, Margaret S.

133

FILTRATION ASSOCIATED TO TORSION SEMI-STABLE ...  

E-Print Network (OSTI)

extension of Qp and ?i : G ? GLd(OE) for i = 1, 2 two Galois representations such .... in Mr tor(?, N, Fil) such that. (1) if there exists a morphism of lifts ˆf : j.

2014-09-12T23:59:59.000Z

134

A copula-based heuristic for scenario generation  

E-Print Network (OSTI)

tor with standard uniform margins, i.e. a function C : [0,1] n ? [0,1]. The Sklar's ..... generated margin samples Mr,i, sorted for each margin i. The right table ...

2013-08-27T23:59:59.000Z

135

Gordon Research Conferences  

Science Journals Connector (OSTI)

...Ventura, CA Chair: Robert Kostecki Vice Chair: Dean Wheeler Novel Strategies for Electrical Energy Storage...Tor Ny / Toni Antalis) Cardiovascular Biology (Katherine Hajjar / Katherine Hajjar / Tetsu Urano / Marie-Christine Bouton...

2013-09-27T23:59:59.000Z

136

Technische Potentiale zur Veränderung des deutschen Energiesektors  

Science Journals Connector (OSTI)

Die Orientierung von Energiewirtschaft und -politik an den im 5. Kapitel abgeleiteten strategischen Ansatzpunkten mag vielen Unternehmen des Energiesek-tors auf den ersten Blick irreal und utopisch erscheinen: ...

Peter Hofer; Dr. Janina Scheelhaase…

1998-01-01T23:59:59.000Z

137

U.S. West: The Next Energy Nexus  

E-Print Network (OSTI)

as we can, but also develop wind power and solar power andsolar, wind, geothermal, biomass, wave and tidal power. Theyto hydroelectric power (Table 2). Wind genera- tors are the

Davis, Sandra K.; Kear, Andrew R.

2014-01-01T23:59:59.000Z

138

LA-UR-  

Office of Scientific and Technical Information (OSTI)

Gaussian Process models tor combining tield data and complex computer simulators field data input settings (spatial locatio ns) ( X n Xl2 ... Xl 1 Px : : : : X n l X n 2 ... X...

139

Immunological investments reflect parasite abundance in island populations of Darwin's finches  

Science Journals Connector (OSTI)

...distribution of parasites (Janzen 1973; Poulin 1997). According to island biogeography...fac- tors (Blaustein et al. 1983; Poulin 1997; Moyer et al. 2002). However...virulence can also affect disease dynamics (Poulin 1997). This possibility can currently...

2004-01-01T23:59:59.000Z

140

On Blocking and Anti-Blocking Polyhedra in Infinite Dimensions  

E-Print Network (OSTI)

settings and have been applied to several fundamental problems in graph theory and discrete optimization ... tors or running averages to force the objective function to be finite-valued. To ..... Handbook of the geometry of Banach spaces. Vol.

2013-11-15T23:59:59.000Z

Note: This page contains sample records for the topic "admi nistra tor" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Optics in data center network architecture  

E-Print Network (OSTI)

RU) 1 switch models. TOR 10 EOR Also present in data centersare so-called end-of-row (EOR) switches.An EOR switch derives its name from the fact that it is

Farrington, Nathan

2012-01-01T23:59:59.000Z

142

n the summer of 2009, a team of Cam-bridge University undergraduates  

E-Print Network (OSTI)

biologists have built a new menagerie. Photographic "E. coliroid" darken in response to light. Sen- sor. In 2005, fes- tive researchers "wrote" the first verse of Vik- tor Rydberg's Christmas poem "Tomten

143

More criticism for NIH over 'summary' cut of grants  

Science Journals Connector (OSTI)

... upon a statement written to the Har-vard faculty about the case by Daniel C. Tosteson, dean of Harvard Medical School. Jack McLaughlin, associate direc-tor of the National ...

Seth Shulman

1989-01-26T23:59:59.000Z

144

Gordon Research Conferences  

Science Journals Connector (OSTI)

...Berson, "Stereochemical pathways of thermal and photochemical rearrange-ments...HIPAC-theory and experiment"; R. Sudan (subject to be announced). Electron...semiconduc-tors-experiments"; David Turnbull, "Structure and thermal properties of amorphous solids"; Morrell...

Alexander M. Cruickshank

1970-03-06T23:59:59.000Z

145

Wolverine Caucus ~ Office of Government Relations ~ Alumni Association Please join us for the following 2010  

E-Print Network (OSTI)

and Direc- tor, Office Provost and Executive Vice President Academic Affairs. Health Care Reform: It's Now Law,What Does It Mean for the Health of Michigan's Citizens? Featured speaker: Marianne Udow

Shyy, Wei

146

Cell, Vol. 112, 271282, January 24, 2003, Copyright 2003 by Cell Press Two-Photon Calcium Imaging Reveals  

E-Print Network (OSTI)

concentration, lobe or olfactory bulb, and ultimately in higher olfactoryeach odor elicits a distinct and sparse- calcium-sensitive fluorescent protein (Miyawaki et al., tors, and mates. Drosophila provides an attractive

147

BWXTymes, April 2005, Y-12 National Security Complex newsletter  

NLE Websites -- All DOE Office Websites (Extended Search)

Following recommendations made in Inspec- tor General reports in 1998 and again in 2001, DOE and NNSA have now placed increased em- phasis on including VE techniques and processes...

148

ACCEPTED TO IEEE TRANS. IT; SUBMITTED FEB 2001, REVISED FEB 2002. 100 Binary Intersymbol Interference Channels  

E-Print Network (OSTI)

-passing detec- tor/decoder, we prove two error concentration theorems. Our proofs expand on previous work- check codes, Gallager codes, density evolution, sum-product algorithm, turbo equalization. I

Kavcic, Aleksandar

149

A REVIEW OF LIGHT-WATER REACTOR SAFETY STUDIES. VOLUME 3 OF THE FINAL REPORT ON HEALTH AND SAFETY IMPACTS OF NUCLEAR, GEOTHERMAL, AND FOSSIL-FUEL ELECTRIC GENERATION IN CALIFORNIA  

E-Print Network (OSTI)

nuclear tors. for of of These studies can examine safety systems or safety research programsnuclear power plants, and at risk. to reduce population The Light-water Reactor Safety Research Program

Nero, A.V.

2010-01-01T23:59:59.000Z

150

Gordon Research Conferences  

Science Journals Connector (OSTI)

...Polysac-charide adsorbents for ethanol-water separation." Membrane processes...boundaries in semiconduc-tors:" Gallium arsenide thin films (C. B. Duke, session...transduction." 20 August. Ion and water movements across epithelial membranes...

Alexander M. Cruickshank

1981-03-13T23:59:59.000Z

151

News of Science  

Science Journals Connector (OSTI)

...the two newly appointed natural scientists-Karl Eric...stories from Japanese natural scientists who keep a...scien-tists, oil heat, a gas stove and refrigera-tor...THOM-SON, master of Corpus Christi College, Cambridge...

1956-08-31T23:59:59.000Z

152

SLAC-PUB-15193 Compact  

Office of Scientific and Technical Information (OSTI)

peak current, and x is the average rms transverse beam size in the undulator. Todd Smith and co-workers at Stanford proposed a "transverse gradient wiggler (undula- tor)"...

153

E-Print Network 3.0 - air act potential Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

spotlight as a Summary: A griculture is in the spotlight as a potential contribu- tor to air pollution. Animal feeding... - eral public should be familiar with the terminol- ogy...

154

Towards Dynamically Adaptive Weather Analysis and Forecasting in LEAD  

E-Print Network (OSTI)

weather phenomena such as tor- nadoes, severe storms and flash floods. The June 1990 outbreak that spawned: ATM-0331594 (Oklahoma), ATM-0331591 (Colorado State), ATM-0331574 (Millersville), ATM-0331480 (Indiana

Plale, Beth

155

PLEASE RUSH  

Office of Legacy Management (LM)

washers out of U v Beta metal slab on punch press. Re No ventilation in area. Oil pH pira tor worn. 1816 1433 BZ Same as 1815 - 32 washers stamp- .02 3 .06 ed in this...

156

An Improved Bioluminescence Resonance Energy Transfer Strategy for Imaging Intracellular Events in Single Cells and Living Subjects  

Science Journals Connector (OSTI)

...An Improved Bioluminescence Resonance Energy Transfer Strategy for Imaging Intracellular...org/ ). Bioluminescence resonance energy transfer (BRET) is currently used for...7175-83] mTOR|Bioluminescence resonance energy transfer|Renilla luciferase|Green...

Abhijit De; Andreas Markus Loening; Sanjiv Sam Gambhir

2007-08-01T23:59:59.000Z

157

Letter Report for Analytical Results for Two Concrete and Three Soil Samples Associated with the Worcester Polytechnic Institute in Worcester Massachusetts  

SciTech Connect

Oak Ridge Associated Universities (ORAU), under the Oak Ridge Institute tor Science and Education (ORISE) contract, received two concrete core and three soil samples on August 26, 2013 from the Worcester Polytechnic Institute in Worcester, Massachusetts. The samples were received in good condition. The samples were analyzed tor activation and fission products by gamma spectrometry. The sample collection data and identification numbers are tabulated and the gamma spectrometry data are presented. The pertinent procedure reference is included with the data table.

Ivey, Wade

2013-10-07T23:59:59.000Z

158

United States Government  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

LICE F 137: r.e Electr LICE F 137: r.e Electr onic Form App roved by CllR - 1010fJI2002 i/JI~~I United States Government Department of Energy Bonneville Power Admi istration memorandum DATE : REPLY TO AnN OF : KEPR-4 SUBJECT: Environmental Clearance Memorandum TO: Stephen Duncan Project Manager - TERS-3 Proposed Action: Removal of de-stabilized and downed trees resulting from a December 200 8 wind storm on the de-energized Lyons Ultra High Voltage Test Line NO.1. PP&A Project No.: PP&A 1309 Budget Information: Work Order # 184006 Categorical Exclusion Applied (from Subpart 0, 10 C.F.R. Part 1021): B 1.3 Routine maintenance/custodial services for buildings, structures, infrastructures, equipment. Location: Fee-owned ROW on the de-energized Lyons UHV Te st Line No .1 to the south of

159

Council on Environmental Quality | Open Energy Information  

Open Energy Info (EERE)

Environmental Quality Environmental Quality Jump to: navigation, search Logo: Council on Environmental Quality Name Council on Environmental Quality Address 722 Jackson Place Northwest Place Washington, DC Zip 20506 Year founded 1969 Phone number (202) 395-5750 Website http://www.whitehouse.gov/admi Coordinates 38.89943°, -77.0384009° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":38.89943,"lon":-77.0384009,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

160

ClEAN ENERGy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

25 ClEAN ENERGy Relations between the Corps and Southeastern have not always been cordial. The droughts of the late 1980s put pressure on both organizations as well as our preference customers. I came to the realization that we could no longer litigate and legislate; we must negotiate and cooperate. - AdmiNistrAtor JohN A. mcAllister, Jr. (1989-1995) 1 PARTNERS Advancing In November 1989, a new administrator arrived in Elberton to lead SEPA. John A. McAllister, Jr., "Johnny," was a native South Carolinian dedicated to public service through his membership in the National Guard. He was recommended for the Administrator's position by Senator Strom Thurmond (R-SC) a strong supporter of SEPA who happened to be one of the most powerful politicians in

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While these samples are representative of the content of NLEBeta,
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to obtain the most current and comprehensive results.


161

Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin  

SciTech Connect

Phosphoinositide 3-kinase {alpha} (PI3K{alpha}) is a critical regulator of cell growth and transformation, and its signaling pathway is the most commonly mutated pathway in human cancers. The mammalian target of rapamycin (mTOR), a class IV PI3K protein kinase, is also a central regulator of cell growth, and mTOR inhibitors are believed to augment the antiproliferative efficacy of PI3K/AKT pathway inhibition. 2,4-Difluoro-N-{l_brace}2-(methyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl{r_brace}benzenesulfonamide (GSK2126458, 1) has been identified as a highly potent, orally bioavailable inhibitor of PI3K{alpha} and mTOR with in vivo activity in both pharmacodynamic and tumor growth efficacy models. Compound 1 is currently being evaluated in human clinical trials for the treatment of cancer.

Knight, Steven D.; Adams, Nicholas D.; Burgess, Joelle L.; Chaudhari, Amita M.; Darcy, Michael G.; Donatelli, Carla A.; Luengo, Juan I.; Newlander, Ken A.; Parrish, Cynthia A.; Ridgers, Lance H.; Sarpong, Martha A.; Schmidt, Stanley J.; Aller, Glenn S.Van; Carson, Jeffrey D.; Diamond, Melody A.; Elkins, Patricia A.; Gardiner, Christine M.; Garver, Eric; Gilbert, Seth A.; Gontarek, Richard R.; Jackson, Jeffrey R.; Kershner, Kevin L.; Luo, Lusong; Raha, Kaushik; Sherk, Christian S.; Sung, Chiu-Mei; Sutton, David; Tummino, Peter J.; Wegrzyn, Ronald J.; Auger, Kurt R.; Dhanak, Dashyant (GSKPA)

2010-09-30T23:59:59.000Z

162

Browse by Discipline -- E-print Network Subject Pathways: -- Energy,  

Office of Scientific and Technical Information (OSTI)

X Y Z X Y Z Wade, Juli (Juli Wade) - Department of Zoology, Michigan State University Wadsworth, Patricia (Patricia Wadsworth) - Department of Biology, University of Massachusetts at Amherst Wagenaar, Daniel (Daniel Wagenaar) - Division of Biological Sciences, University of California at San Diego Wager, Tor D. (Tor D. Wager) - Department of Psychology, University of Colorado at Boulder Wagner, Andreas (Andreas Wagner) - Department of Biochemistry, Universität Zürich Wagner, Anthony (Anthony Wagner) - Department of Psychology, Stanford University Wagner, Doris (Doris Wagner) - Department of Biology, University of Pennsylvania Wagner, Gerhard (Gerhard Wagner) - Department of Biological Chemistry and Molecular Pharmacology, Harvard University Wagner, Oliver (Oliver Wagner) - Department of Life Sciences,

163

A review of "Decentring the Renaissance: Canada and Europe in Multidisciplinary Perspective, 1500-1700." by Germaine Warkentin and Carolyn Podruchny, eds.  

E-Print Network (OSTI)

.00. Review by TY M. REESE, UNIVERSITY OF NORTH DAKOTA. This edited collection of post-colonial ?decentring? essays re-examines early cultural interaction in Canada. The contribu- tors hope to better understand the Renaissance, and how it influ- enced initial....00. Review by TY M. REESE, UNIVERSITY OF NORTH DAKOTA. This edited collection of post-colonial ?decentring? essays re-examines early cultural interaction in Canada. The contribu- tors hope to better understand the Renaissance, and how it influ- enced initial...

Ty M. Reese

2002-01-01T23:59:59.000Z

164

The catalytic oxidation of propane and propylene with air: total aldehyde production and selectivity at low conversions.  

E-Print Network (OSTI)

~ Ths writer is izntebteg to pr, P G~ ~och Tor his assistance azsi guidance in this work aC to Br~ J+ 9 Kinds Tor his aery. suggestions eel Succor~ a The oxidation cf propane~ propylene and prcya~cregyimm mbetccres ctver a ~ aiucdna ~st in a flew... formation of aldehyde fran pure grade propane The ~ce of Within the range of variables of this investigation and with propylene ~& aldehyde pr~cn was f'ennd to bs independent of" residence Qorrcgations relating aldehyde pressure to ~ and cncygsn pressure...

Looney, Franklin Sittig

2012-06-07T23:59:59.000Z

165

Nucleotide sequence of the genes, encoding the pentaheme cytochrome (dmsC) and the transmembrane protein (dmsB) involved in dimethyl sulfoxide respiration from Rhodobacter sphaeroides f. sp. denitrificans  

Science Journals Connector (OSTI)

The nucleotide sequence of the genes encoding a pentaheme cytochrome (dmsC) and a transmembrane protein (dmsB) were determined upstream of the dmsA gene encoding dimethyl sulfoxide reductase from Rhodobacter sphaeroides f. sp. denitrificans. dmsC and dmsB encode proteins of 404 and 226 amino acid residues, which show 40% and 26% identity to the pentaheme cytochrome TorC and the transmembrane protein TorD, respectively, of the trimethylamine N-oxide reduction system in Escherichia coli.

Takeshi Ujiiye; Isamu Yamamoto; Hiroshi Nakama; Akira Okubo; Sunao Yamazaki; Toshio Satoh

1996-01-01T23:59:59.000Z

166

FOR IMMEDIATE RELEASE CONTACT: MATT LETOURNEAU  

U.S. Energy Information Administration (EIA) Indexed Site

FOR IMMEDIATE RELEASE CONTACT: MATT LETOURNEAU APRIL 8, 2008 (202) 224-6977 mrep~red qext of rKpK pen~tor mete sK aomenici's oem~rks ~t bf^'s ^nnu~l bnergy `onference OMMU Thank you, Administrator Caruso, for that introduction, and for the invitation to speak here this morning.

167

ARTICULATORY OPTIMISATION IN PERTURBED VOWEL ARTICULATION  

E-Print Network (OSTI)

in relation to the palatal change, afterwards speakers explore different production mechanisms which in. In this context, speech production planning then would inverse the process by finding a set of mo- tor commands process. Under perturbation, the speech production system is changed; as a consequence parts

Paris-Sud XI, Université de

168

Multi-Touch Rotation Gestures: Performance and Ergonomics  

E-Print Network (OSTI)

Multi-Touch Rotation Gestures: Performance and Ergonomics Eve Hoggan1 , John Williamson2 , Antti multi-touch gestures, yet little is known about the fac- tors affecting performance and ergonomics; gestures; ergonomics. ACM Classification Keywords H.5.2. User Interfaces: Evaluation/Methodology, Input De

169

IEEE BCTM5.1 Dependenceof ThermalResistanceon Ambientand Actual Temperature  

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the temperature dependence of the thermal resistance. We extract the thermal resistance as function of ambient, that the temperature dependence of the thermal resistance has not yet being taken into account. It is well-known that the thermal conductivity changes with temperature [I]. For many ofthe,materials used in semiconduc- tor

Technische Universiteit Delft

170

Dynamic Positioning System as Dynamic Energy Storage on Diesel-Electric Ships  

E-Print Network (OSTI)

1 Dynamic Positioning System as Dynamic Energy Storage on Diesel-Electric Ships Tor A. Johansen in order to implement energy storage in the kinetic and potential energy of the ship motion using the DP in order to relate the dynamic energy storage capacity to the maximum allowed ship position deviation

Johansen, Tor Arne

171

Amplitude Dependence of Time of Flight J. Scott Berg  

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Mu onAccelera tor Program Front End Chicane Parameters J. Scott Berg Brookhaven National Laboratory in chicane length and angle 25 March 2014 J. S. Berg | Chicane | Front End Meeting (2) #12;Performance proton energy, but left many high energy protons. 25 March 2014 J. S. Berg | Chicane | Front End Meeting

Berg, J. Scott

172

Physics centre threatened  

Science Journals Connector (OSTI)

... Washington. Fusion research at the Prince-ton Plasma Physics Laboratory (PPPL), one of the principal US fusion research centres, would be shut down for ... Experimental Reac-tor, to which the United States is a sub-scriber, and on PPPL's new project, the Tokamak Physics Experiment. The TFTR (Tokamak Fusion Test Reactor) ...

Traci Watson

1992-12-10T23:59:59.000Z

173

Wind Plant Collector System Fault Protection and Coordination  

SciTech Connect

This paper presents a summary of the most important protection and coordination considerations for wind power plants. Short-circuit characteristics of both aggregate wind plant and individual wind turbine genera- tors, as well as general interconnection protection requirements are discussed. Many factors such as security, reliability, and safety are considered for proper conservative protection of the wind power plant and individual turbines.

Bradt, M. [IEEE PES Wind Plant Collector System Design Working Group; Behnke, M. R. [IEEE PES Wind Plant Collector System Design Working Group; Bloethe, W.G. [IEEE PES Wind Plant Collector System Design Working Group; Brooks, C. [IEEE PES Wind Plant Collector System Design Working Group; Camm, E H [IEEE PES Wind Plant Collector System Design Working Group; Dilling, W. [IEEE PES Wind Plant Collector System Design Working Group; Goltz, B. [IEEE PES Wind Plant Collector System Design Working Group; Li, J. [IEEE PES Wind Plant Collector System Design Working Group; Niemira, J. [IEEE PES Wind Plant Collector System Design Working Group; Nuckles, K. [IEEE PES Wind Plant Collector System Design Working Group; Patino, J. [IEEE PES Wind Plant Collector System Design Working Group; Reza, M [IEEE PES Wind Plant Collector System Design Working Group; Richardson, B. [IEEE PES Wind Plant Collector System Design Working Group; Samaan, N. [IEEE PES Wind Plant Collector System Design Working Group; Schoene, Jens [IEEE PES Wind Plant Collector System Design Working Group; Smith, Travis M [ORNL; Snyder, Isabelle B [ORNL; Starke, Michael R [ORNL; Walling, R. [IEEE PES Wind Plant Collector System Design Working Group; Zahalka, G. [IEEE PES Wind Plant Collector System Design Working Group

2010-01-01T23:59:59.000Z

174

Seeing the Forest for the Trees: Kidney Oncogenomes in Relation to Therapeutic Outcomes  

Science Journals Connector (OSTI)

...activation have not proved so far to provide robust discriminating power in selecting patients who may benefit most from mTOR inhibitor...microenvironment (akin to the natural pressures of sunlight, wind, or soil that will force a tree to adopt a particular shape...

David D. Chism and W. Kimryn Rathmell

2014-04-01T23:59:59.000Z

175

ISocRob 2009 Team Description Paper  

E-Print Network (OSTI)

;Actuators: ­ Each of the robot's three Swedish wheels is actuated by a MAXON DC mo- tor (model RE35/s; ­ In order to kick the ball, an electromagnetic strength controlled kicker is used; ­ To aid in ball with omnidirec- tional vision, capable of detecting relevant objects (such as the ball and other robots

Instituto de Sistemas e Robotica

176

Analysis of the Fungal Virulence of Cryptococcus and Exploration of Novel Antifungals Against Cryptococcosis  

E-Print Network (OSTI)

-? Interferon-? IRZ Itracazole MAT Mating Type MFC Minimum Fungicidal Concentration MIC Minimum Inhibitory Concentration MOPS morpholinepropanesulfonic acid vi mTOR mammalian Target Of Rapamycin PDCD4 Programmed Cell Death 4 PMB Polymyxin B PMDD... proliferative and non- proliferative cryptococcal cells in vitro ..................................................... 79 3.3.6. The polysaccharide capsule of Cryptococcus facilitates the fungicidal activity of polymyxin B...

Zhai, Bing

2014-08-01T23:59:59.000Z

177

Directed Evolution of Protein Inhibitors of DNA-nucleases by in Vitro Compartmentalization (IVC) and  

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compartmentalization (IVC) uses water-in-oil emulsions to create artificial cell-like compartments in which genes can for inhibi- tors by binding of the target enzyme may yield proteins or peptides that tightly bind the enzyme by enzymatic, regulatory and inhibitory activities. The basic concept is quite simple: a water- in-oil (w

Tawfik, Dan S.

178

Weblog Analysis for Predicting Correlations in Stock Price Evolutions Milad Kharratzadeh1  

E-Print Network (OSTI)

method which combines information from the weblog data and histor- ical stock prices. Through simulation strategies based on company sec- tors or historical stock prices. This suggests that the method- ology has evolution of stock prices and whether this is complementary to the information embedded in historical stock

Coates, Mark

179

Prospects for attractive fusion power systems  

Science Journals Connector (OSTI)

...Robinson Prospects for attractive fusion power systems Farrokh Najmabadi...commercial product. Today's fusion experiments, by their charter...power plant; the International Thermonuclear Experimental Reac- tor (ITER...for rapid maintenance of the fusion core (the so-called mean...

1999-01-01T23:59:59.000Z

180

Gordon Research Conferences  

Science Journals Connector (OSTI)

...Comsa, "Thermal helium scattering...moderately large deformations...leader). Non-accelera-tor...Effects of atmospheric oxida-tion...sperm-egg plasma membrane fusion...Bala-ban, "Large-scale protein...Space Plasma Physics Proctor...Dynamical non-equilibrium...magneti-cally confined plasmas"; M. Rush-bridge...

Alexander M. Cruickshank

1985-03-01T23:59:59.000Z

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181

PERFORMANCE STATUS OF THE RF-GUN BASED INJECTOR OF THE TESLA TEST FACILITY LINAC  

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PERFORMANCE STATUS OF THE RF-GUN BASED INJECTOR OF THE TESLA TEST FACILITY LINAC S. Schreiber. For this, an rf-gun based photoinjec- tor was installed late 1998 and is in operation since then gun [4] to match the beam charcteristics as close as pos- sible to the TESLA proposal. It is able

182

Towards Configurable Data Collection for Sustainable Supply Chain Communication  

E-Print Network (OSTI)

://www.uni-ulm.de/dbis Abstract. These days, companies in the automotive and electronics sec- tor are forced by legal regulations and the pub- lic opinion demand sustainability compliance from companies, especially in the electronics and automotive sector. Therefore, companies have to report certain sustainability indicators as, e

Ulm, Universität

183

advertising feature an8 | December 2009 | nature methods  

E-Print Network (OSTI)

for such incuba- tors include exact temperature control and very even temperature distribution. CO2 must, humidity and CO2 will reduce the lifetime of its drive system. Furthermore, the heat generated supplemented with CO2 and humidity suffer from unwanted condensation and high losses of CO2 to the lab

Cai, Long

184

Evaluating Parameter Sweep Workflows in High Performance Computing*  

E-Print Network (OSTI)

Evaluating Parameter Sweep Workflows in High Performance Computing* Fernando Chirigati1,# , Vítor a large amount of tasks that are submitted to High Performance Computing (HPC) environments. Different, Parameter Sweep, High Performance Computing (HPC) 1. INTRODUCTION1 # Many scientific experiments are based

Paris-Sud XI, Université de

185

Palladium Devices for Gas Chromatography  

Science Journals Connector (OSTI)

......the discovery that the generator-separa- tor cell...GC detector. When a generator-separator such as...CATHODE AND HYDROGEN GENERATOR Figure 9. Conceptual...dioxide, propylene, water, acetaldehyde, and...been investigated at atmospheric pressure and in a tempera......

J. E. Lovelock; P. G. Simmonds; G. R. Shoemake; S. Rich

1970-08-01T23:59:59.000Z

186

nATuRE CommunICATIons | 2:286 | DoI: 10.1038/ncomms1283 | www.nature.com/naturecommunications 2011 Macmillan Publishers Limited. All rights reserved.  

E-Print Network (OSTI)

for High Technology Materials, University of New Mexico, Albuquerque, New Mexico 87106, USA. 3 QmagiQ, LLC that lead to the self-assembly of oil droplets on a water surface5 . In particular, the dots-in-a-well (DWELL) detec- tor architecture pioneered at the University of New Mexico was used as a prototype

Krishna, Sanjay

187

Tank Opening Report No 77 Page 1 Pump Out 24 Feb -Close Doors 28 Feb 92  

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Tank Opening Report No 77 Page 1 Pump Out 24 Feb - Close Doors 28 Feb 92 Reason for Tank Opening Replace terminal stripper foils. Preamble The tank was last open from 8 - 12 July 1991 and has since run 2 readers will know, the Tank Opening Report reliability has been abysmal. Since TOR 72, there have been

Chen, Ying

188

Copyright 1999 The Association of Universities for Research in Astronomy, Inc. All Rights Reserved. Instrument Science Report ACS 2001-004  

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of small scale detec- #12;Instrument Science Report ACS 2001-004 2 tor defects and to recover some accurate, although not necessarily optimal. An upgrade path is outlined which could lead to significantly of drizzle in calacs, highlight decisions that need to be made, and identify a possible upgrade path. Our

Sirianni, Marco

189

Automating Dynamic Decoupling in Object-Oriented Modelling and Simulation Tools  

E-Print Network (OSTI)

a Modelica transla- tor. Simulation tests demonstrate the technique, and the re- alised implementation than of simulation theory. In this work we refer as "EOO Modelling Tool" to a Modelica translator, to allow exemplifying the (more general) presented ideas. For a Modelica translator, the EOO modelling

Como, Giacomo

190

A Novel Class of Monoglutamated Antifolates Exhibits Tight-binding Inhibition of Human Glycinamide Ribonucleotide Formyltransferase and Potent Activity against Solid Tumors  

Science Journals Connector (OSTI)

...bioavailable inhibitor of Class I PI3 kinase and...lines, with the greatest potency in breast...with selectivity for class I PI3K and mTOR kinase...responsible for the greater cell potency of GDC-0980...bioavailable inhibitor of Class I PI3 kinase and...lines, with the greatest potency in breast...

Lillian L. Habeck; Tracy A. Leitner; Katherine A. Shackelford; Lynn S. Gossett; Richard M. Schultz; Sherri L. Andis; Chuan Shih; Gerald B. Grindey; and Laurane G. Mendelsohn

1994-02-15T23:59:59.000Z

191

American Institute of Aeronautics and Astronautics Copyright 1997 by Alan H. Epstein.  

E-Print Network (OSTI)

in progress on microelectrical and mechanical systems (MEMS)-based gas turbine en- gines, turbogenerators with the same power density as that achieved in their more familiar, full-sized brethren. The micro-gas turbine- drocarbon fuels. A liquid fuel, bi-propellant rocket mo- tor of similar size could develop over 3 lb

Frechette, Luc G.

192

XX.Faculty/CorpsEnseignant XX. Faculty/Corps  

E-Print Network (OSTI)

temps plein Abella, Irving M., CM, BA, MA, PhD (Tor.), FRSC, Prof., Hist., Arts Abergel, Elisabeth, BSc.), Prof., Phil., Atkinson Adelson, Naomi, BA (McG.), MA (McM.), PhD (McG.), Assoc. Prof., Anthro., Arts Alan, Sule, BSc (Middle East Tech.), MA (York), PhD (McM.), Assist. Prof., Econ., Arts Albo, Gregory A

193

A Distribution-Based Approach to Tracking Points in Velocity Vector Fields Liefei Xu, H. Quynh Dinh  

E-Print Network (OSTI)

vector field points, and show results of tracking points in the simulated flow through a diesel engine Lin School of Electrical Engineering and Computer Science Oregon State University zhange- tors). A fundamental task in flow analysis is the ability to extract features and track their movements

Dinh, H. Quynh

194

DEVELOPMENT OF PHONON-MEDIATED CRYOGENIC PARTICLE DETECTORS WITH  

E-Print Network (OSTI)

of detectors which are able to reject background events by simultane- ously measuring energy deposited into phonons versus electron hole pairs. By using the phonon sensors with the ionization sensors to compare (background radiation) and nuclear recoil events (dark matter events). These detec- tors with built

California at Berkeley, University of

195

MFR PAPER 1097 Plastic Turf Substitute for Gravel in Salmon Incubators  

E-Print Network (OSTI)

layer Dun ng the next 2 or 3 wee\\... . the alevins distnbuted them ehes until they were evenly dlsper ed they emerged a~ fry. The pea\\... of emergence occurred In April conc urren tl y with th e pea\\... of emergence of fry from gravel Incuba- tors. Survival from eyed eggs to fry In th e Incubator With the turf substrate

196

IEEE TRANSACTIONS ON ENERGY CONVERSION, VOL. 21, NO. 2, JUNE 2006 619 Direct Torque Control of Induction Motor With Fuzzy Stator  

E-Print Network (OSTI)

--Direct torque control, fuzzy logic, induction mo- tor, stator resistance. I. INTRODUCTION DIRECT torque control logic is proposed. The input variables of the fuzzy logic identifier are the input and output of the low the fuzzy estimator and a classical integrator in a direct torque control (DTC) scheme prove the superiority

Paris-Sud XI, Université de

197

E-Print Network 3.0 - anel da valva Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

PhoTomonTage: daTagr af... . mobile AnD sUsTAinAble Dwellings in greenlAnD's vAcUUm solAr collecTor solAr pAnels solAr-heATeD ch... . The red triangle is the entrance, and the...

198

Energy Self-Sufficiency for Hawaii  

Science Journals Connector (OSTI)

...large windmill in Hawaii-a 200-kW wind turbine genera-tor located at Kahuku on the...purchase of 80 MW of electricity from wind turbine generators to be locat-ed near the 200-kW...Windfarms will finance these huge wind turbines at an estimated total cost of SCIENCE...

John W. Shupe

1982-06-11T23:59:59.000Z

199

Los Alamos National Laboratory Est. 1943 Physics Flash--Newsletter of the Physics Division I N S I D E  

E-Print Network (OSTI)

or a surgeon in a hospital. Then, if she thinks the tool at her disposal might help solve the problem, she 2012 I N S I D E 2 From Steve'S deSk 3 ribbonS cut For majorana demonStra- tor Laboratory one mi Interference Device (SQUID) team leader in Applied Modern Physics (P-21), her tool of choice captures

200

Antimelanoma Effect of 4-S-Cysteaminylcatechol, an Activated Form of 4-S-Cysteaminylphenol  

Science Journals Connector (OSTI)

...reproduc- ibility. Oxidation of 4-S-CAP was performed...counted in a Sysmex F-610 Micro Cell Counter (Kobe...melanoma (2, 24). Oxidation of the catechols by these...Fig. 2. Tyrosinasc oxidation and autoxidation of Cysteaminyldiphenols...measured by HPLC. The data arc averages tor two determinations...

Shigeki Inoue; Katsutoshi Hasegawa; Shosuke Ito; Hiroyuki Ozeki; Francisco Solano; Celia Jiménez-Cervantes; Kazumasa Wakamatsu; and Keisuke Fujita

1995-06-15T23:59:59.000Z

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to obtain the most current and comprehensive results.


201

Scenario-Based Fault-Tolerant Model Predictive Control for Diesel-Electric Marine Power Plant  

E-Print Network (OSTI)

Scenario-Based Fault-Tolerant Model Predictive Control for Diesel-Electric Marine Power Plant where diesel gener- ator sets (a diesel engine connected to a generator) produce electrical power, which Email: torstein.bo@itk.ntnu.no, tor.arne.johansen@itk.ntnu.no Abstract--Diesel-electric propulsion

Johansen, Tor Arne

202

Cotton Production in Far West Texas with Emphasis on Irrigation and Fertilization.  

E-Print Network (OSTI)

production have not even been ap- *Respectively, associate agronomist, Substation No. 17, El Paso, Texas; associate agronomist, Substation No. 9, Pecos, Texas; and superintendent and research coordina- tor, Substation No. 17, El Paso, Texas. proached... on Cotton Yields 5 ....................................................................... Substation 17 5 ................................................................................. Fabens 6 Pecos...

Longenecker, D. E. (Donald E.); Thaxton, E. L.; Lyerly, P. J. (Paul J.)

1963-01-01T23:59:59.000Z

203

Developing Operator Models for UAV Search Scheduling L. F. Bertuccelli, N. W. M. Beckers, and M. L. Cummings  

E-Print Network (OSTI)

Developing Operator Models for UAV Search Scheduling L. F. Bertuccelli, N. W. M. Beckers, and M. L. Cummings With the increased use of Unmanned Aerial Vehicles (UAVs), it is envisioned that UAV opera- tors. In the context of search missions, operators supervising a large number of UAVs can be- come overwhelmed

Cummings, Mary "Missy"

204

Center for Transportation Training and Research Texas Southern University  

E-Print Network (OSTI)

Center for Transportation Training and Research Texas Southern University Carol Lewis, Ph.D. Director, Center for Transportation Training and Research, and SWUTC Executive Committee Member Texas is an Associate Professor in Transportation Studies and Direc- tor of the Center for Transportation Training

205

[McC86] John McCarthy. Application of circumscription to formaliz ing commonsense knowledge. Artificial Intelligence, 28:89--116,  

E-Print Network (OSTI)

:365--385, 1991. [GM92] John Grant and Jack Minker. Deductive database systems. In Stuart C. Shapiro, editor C. Shapiro, editor, Encyclopedia of Artificial Intelligence, pages 873-- 891. John Wiley & Sons, 2nd. Constraint networks. In Stuart C. Shapiro, edi­ tor, Encyclopedia of Artificial Intelligence, pages 276

Dechter, Rina

206

CONTRIBUTIONS TO THE KNOWLEDGE OF VIBRIO CHOLERAE I. FERMENTATION OF CARBOHYDRATES AND POLYATOMIC ALCOHOLS BY VIBRIO CHOLERAE  

Science Journals Connector (OSTI)

...of V. cholerae in natural sea and river water...but fails to form gas, while ami-don...1805 El-Tor, Egypt Onrginal och...in small Durham's gas tubes, 2 cc. in...the glycerol from Price-London were fermented...B and C). ii. Gas production: With...

Keizo Nobechi

1925-05-01T23:59:59.000Z

207

Detecting Structure in Diffusion Tensor MR Images K. Krishna Nand1  

E-Print Network (OSTI)

Detecting Structure in Diffusion Tensor MR Images K. Krishna Nand1 , Rafeef Abugharbieh1 , Brian G. Booth2 , and Ghassan Hamarneh2 1 Biomedical Signal and Image Computing Lab, University of British to DTI using our differential opera- tors. Results using the feature detectors on diffusion tensor MR

Hamarneh, Ghassan

208

http://www.pppl.gov Stabilization  

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Pressurized He atmosphere V V V Li jets Li jets TFC I B tor D2 Plasma PRINCETON PLASMA PHYSICS LABORATORY PPPLhttp://www.pppl.gov =) Meetings =)Lithium Walls 2000 Stabilization of tokamak plasma by lithium streams Leonid E. Zakharov, Princeton University , Princeton Plasma Physics Laboratory Presented to APS

Zakharov, Leonid E.

209

Unit Commitment of Generator Sets During Dynamic Positioning Operation Based on  

E-Print Network (OSTI)

Simulation Torstein I. Bø Tor Arne Johansen Eirik Mathiesen Center for Autonomous Marine Operations positioning system, diesel-electric propulsion is often used. At all time the vessel should be able decades diesel-electric propulsion has become industry standard for some types of vessels such as drilling

Johansen, Tor Arne

210

Lithium Insertion In Silicon Nanowires: An ab Initio Study  

E-Print Network (OSTI)

, Department of Materials Science and Engineering, Stanford University, Stanford, California 94305 storage capacity of Si nanowires (SiNWs) has been demonstrated recently and has opened up exciting transis- tors,1-3 nanosensors,4-6 and solar cells.7-9 These applications take advantage of the high

Cui, Yi

211

Energy and Water  

Science Journals Connector (OSTI)

...fac-tors, including land use, air and water pollution, economics, and occupational hazards, must be included in any overall...agri-cultural wastewater; the economic feasi-bility of desalination; the results of fur-ther research on groundwater and its...

John Harte; Mohamed El-Gasseir

1978-02-10T23:59:59.000Z

212

Ultrafast Vibrationally-Induced Dephasing of Electronic Excitations in  

E-Print Network (OSTI)

-3-1 Hongo, Bunkyoku, Tokyo 113-8656, Japan, and Theory DiVision, Los Alamos National Lab, New Mexico 87545 is almost independent of the electronic excitation energy and occurs faster for biexcitons than single solar cells,5 field-effect transis- tors,6 and other nanometer-sized devices. The quasi

213

arXiv:cond-mat/0408020v12Aug2004 Electric generation of spin in crystals with reduced symmetry  

E-Print Network (OSTI)

arXiv:cond-mat/0408020v12Aug2004 Electric generation of spin in crystals with reduced symmetry of spin accumulation in semiconduc- tors, we propose a way of generating a spin polarization in crystals with strong spin-orbit interac- tions. We show that, in the presence of an electric field, there exists

Niu, Qian

214

griculture is in the spotlight as a  

E-Print Network (OSTI)

, cyclone exhaust, facility or mine. Fugitive emissions -- Air pollutants that escape unplanned, as fromA griculture is in the spotlight as a potential contribu- tor to air pollution. Animal feeding emit air pollutants. Clean Air Act -- The law passed in 1970 (and subsequent amendments) that created

Mukhtar, Saqib

215

Atmos. Chem. Phys., 10, 19691988, 2010 www.atmos-chem-phys.net/10/1969/2010/  

E-Print Network (OSTI)

. Correspondence to: J. P. D. Abbatt (jabbatt@chem.utoronto.ca) 1 Introduction Air pollutants have important the atmo- sphere either as a result of primary emissions such as fossil fuel combustion or through within each solution. The PMF analysis yielded a 6-factor solution that included fac- tors characteristic

Meskhidze, Nicholas

216

Automatic Headspace and Programmed Temperature Vaporizer (PTV) Operated in Cryo-Enrichment Mode in High Resolution Gas Chromatography  

Science Journals Connector (OSTI)

......n of liquid nitrogen p r o v i d...thus avoiding water condensation...SE-30 on Gas Chrom Q. Carbotrap...SE-30 on Gas Chrom Q; PTV...decrease the water solubility fac tor of...liquid a n d gas phases. F...from p u r e water used as a b......

F. Poy; L. Cobelli

1985-03-01T23:59:59.000Z

217

Open-surface MHD flow over a curved wall in the 3-D thin-shear-layer approximation  

E-Print Network (OSTI)

*, M. Abdou Department of Mechanical and Aerospace Engineering, Fusion Sciences and Technology Group example is a liquid-wall flow in a fusion reac- tor. Recently, the liquid-wall concept has a significant place in the advanced power extraction (APEX) study [1]. In one of the APEX designs, liquid metal

Abdou, Mohamed

218

ELSEVIER Physica B 213&214 11995J454 458 Neutron scattering from liquid 3He  

E-Print Network (OSTI)

ELSEVIER Physica B 213&214 11995J454 458 HIYSICA[ Neutron scattering from liquid 3He at large Abstract Neutron inelastic scattering measurements have been made on liquid 3He at 1,4 K for wave vectors to investigate the neutron inelastic scattering from liquid 3He at T = 1.4 K for wave vec- tors between 9 and 20

Glyde, Henry R.

219

The University of Mississippi-Grenada offers graduate degree programs geared to working adults, including  

E-Print Network (OSTI)

class, textbook costs, a laptop computer, and a classroom instruc- tional enhancement grant. Further Administration) prepare professional educators to become school administra- tors.This program can be completed-Grenada ITC Building Find us on Facebook! #12;UM/ School District Bank Hours The UM School of Education offers

Tchumper, Gregory S.

220

Vol.4, Special Issue I, **-** (2012) Health Pharmacological manipulation of cannabinoid  

E-Print Network (OSTI)

,212-2, an endocannabinoid receptor agonist, and URB597, an inhibitor of endocannabinoid catabolism, or memantine, a non neurodegenerative diseases. Keywords: Rats; Memantine; UCM707; Microglia; WIN-55,212-2; URB597 1. INTRODUCTION,21]. Memantine, an open-channel, non-competi- tive, low-affinity, N-methyl-d-aspartate (NMDA) recap- tor

Wenk, Gary

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to obtain the most current and comprehensive results.


221

The Distributed Stigmergic Algorithm for Multi-parameter Optimization  

E-Print Network (OSTI)

Stig- mergy Algorithm (MASA) for minimizing the power losses in an electric motor by optimizing to the electric motor design in Section 5. Finally, we conclude the paper in Section 6. 2 The Ant Stigmergy the independent geometrical parameters of the ro- tor and the stator. The efficiency of the algorithm

Silc, Jurij

222

Fourth AnnuAl SummEr School on  

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, Canberra) Discussants: Leopoldo Nuti(Università roma Tre), federico romero(eui) Panel 4 - Getting public michele di donato(Università roma Tre),lars Stöcker(eui) Discussants:Silvio pons(Università roma Tor

223

Origin of the Springtime Westerly Bias in Equatorial Atlantic Surface Winds in the Community Atmosphere Model Version 3 (CAM3) Simulation  

E-Print Network (OSTI)

­atmosphere interaction generally rules. 1. Introduction Trade winds (easterlies) prevail over most of the tropical in the cen- tral and eastern basins, and vice versa. Along the equa- tor, easterly winds generate equatorialOrigin of the Springtime Westerly Bias in Equatorial Atlantic Surface Winds in the Community

Nigam, Sumant

224

Aeroacoustic noise prediction for SRM Sylvain Parrangab, Javier Ojedaa, Sofiane Khelladib, Mohamed Gabsia  

E-Print Network (OSTI)

for reliability, low cost and high torque at low speed makes the switched reluctance motor (SRM) look like a good focuses on the switched reluctance mo- tor (SRM). As noise is a major perturbation in our everyday lives, Paris, France 2014-01-10 Abstract High speed motors produce an important aeroacoustic noise which

225

As a gesture of thanks for your life membership, the UF Alumni Association is offering a $25 rebate for the Gator  

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for the Gator Nation state of Florida license plate*. To take advantage of this offer, follow these simple steps: · Purchase a Gator Nation license plate at any Florida county tag agency. · Complete the form below and print-2425 ZPPF again, Thank you for your life MeMbership and go gaTors! *To be redeemed for new plate purchases

Mazzotti, Frank

226

Errors and Uncertainty in Mineral Resource and Ore Reserve Estimation: The Importance of Getting it Right  

Science Journals Connector (OSTI)

...Macquarie University, Sydney. BUTCHER, R.J...of London Publishing House, Bath, p. 37-45...errors can give the mine opera-tor significant problems...Macquarie University, Sydney. BUTCHER, R.J...of London Publishing House, Bath, p. 37-45...

SIMON C. DOMINY; MARK A. NOPPÉ; ALWYN E. ANNELS

227

Lyapunov-based Optimizing Control of Nonlinear Blending Process  

E-Print Network (OSTI)

. I. INTRODUCTION Blending processes arise in a wide range of industries, for example gasoline1 Lyapunov-based Optimizing Control of Nonlinear Blending Process Tor A. Johansen£ , Daniel Sb. ££ Department of Electrical Engineering, University of Concepci´on, Concepci´on, Chile. Abstract Blending

Johansen, Tor Arne

228

Lyapunov-based Optimizing Control of Nonlinear Blending Processes  

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processes arise in a wide range of industries, for example gasoline blending [1], [2], [3], [4], food1 Lyapunov-based Optimizing Control of Nonlinear Blending Processes Tor A. Johansen , Daniel Sb. Department of Electrical Engineering, University of Concepci´on, Concepci´on, Chile. Abstract Blending

Johansen, Tor Arne

229

MSU Extension Publication Archive Archive copy of publication, do not use for current recommendations. Up-to-date  

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by these conversion fac- tors, diesel engines are more fuel efficient than gasoline engines. *This project farm operations for fuel consumption. Table 1 reports the results of thousands of observations, in some of diesel fuel used per acre for various operations. Also shown are the high and low values (on an over- all

230

www.afm-journal.de 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim 4427  

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-oxide-semiconductor (CMOS) transis- tors and simple circuits, solar cells, strain/temperature sensors, digital imaging and bio- logically benign end products. This type of technology, sometimes referred to as a class-inspired organic active and passive materials.[8�10] An important advance followed from the obser- vation

Rogers, John A.

231

Reducing Energy Usage in Extractive Distillation  

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the economics of the entire unit. An optimization program has been initia ed to develop the necessary information in the field. It is planned to make small, design d changes in the variable of interest and mon'tor the process response. This information wou...

Saxena, A. C.; Bhandari, V. A.

232

Analysis of tidal current observations over the northeastern shelf of the Gulf of Mexico  

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of the controlling fac- tors of the currents in this area, mainly the wind and the tide (Boston, 1964), have been studied only briefly. This thesis is concerned with (a) the task of obtaining direct field measurements of the current by employing a taut-line buoy...

Durham, Donald L

1967-01-01T23:59:59.000Z

233

Supplement of Atmos. Chem. Phys., 14, 45734585, 2014 http://www.atmos-chem-phys.net/acp-14-4573-2014/  

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., 1993,2007,2011) to quantify organic carbon (OC) and elemental carbon (EC).11 The remaining quartz-fiber) Carbonaceous component (organic carbon, elemental carbon) 22hrsc IMPROVE-TOR (DRI Model 2001A Carbon Analyzer the quartz-fiber9 filter was submitted to the IMPROVE_A thermal-optical reflectance protocol (Chow10 et al

Meskhidze, Nicholas

234

Effect of Cations on Activation of Bacillus popilliae Spores  

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...not affected by so- dium, cesium, or lithium. Divalent cations may be required for...tors was also compared by adding an excess of either compound to suspensions of spores...Effect on the viable count ofadding excess KCI or EDTA to spores being heated in...

D. F. Splittstoesser; D. F. Farkas

1966-10-01T23:59:59.000Z

235

Abstract--In this paper, the performances of a hybrid ex-citation flux switching permanent magnets synchronous  

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High efficiency, high power factor, high Tor- que/Volume ratio, high torque and speed operating points solution [3] while it combines the advantages of the permanent magnets machines and wound rotor synchronous iron parts, classical armature wind- ings and additional DC excitation coils situated above

Paris-Sud XI, Université de

236

Booting Linux: The History and the Future Werner Almesberger  

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Booting Linux: The History and the Future Werner Almesberger Werner.Almesberger@ep .ch June 25, 2000 Abstract Booting an operating system means to mediate be- tween a usually very basic beginnings of the oppy boot sec- tor, the Linux boot process has grown rich function- ality, with versatile

Almesberger, Werner

237

36.th EPS-CPP, June 30.th 2009 -Sofia ITER Session  

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36.th EPS-CPP, June 30.th 2009 - Sofia ITER Session F. Zonca - The FAST Proposal Associazione Tor Vergata Univ. of Catania #12;36.th EPS-CPP, June 30.th 2009 - Sofia ITER Session F. Zonca & construction #12;36.th EPS-CPP, June 30.th 2009 - Sofia ITER Session F. Zonca - The FAST Proposal Associazione

Zonca, Fulvio

238

Receptive Field Organization Determines Pyramidal Cell Stimulus-Encoding Capability and Spatial Stimulus Selectivity  

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field around the body via an electric organ and continuously monitor this electric organ discharge (EOD). Electrorecep- tors designed to encode the amplitude and the timing of the EOD (Scheich et al., 1973) project to as E and I cells because they respond to increased EOD amplitude with excitation and i

Chacron, Maurice

239

Heat Shock Factor 1 Is a Powerful Multifaceted Modifier of Carcinogenesis  

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Heat Shock Factor 1 Is a Powerful Multifaceted Modifier of Carcinogenesis Chengkai Dai,1 Luke: lindquist_admin@wi.mit.edu DOI 10.1016/j.cell.2007.07.020 SUMMARY Heat shock factor 1 (HSF1) is the master regula- tor of the heat shock response in eukaryotes, a very highly conserved protective mechanism. HSF1

Lindquist, Susan

240

COPYRIGHT NOTICE: Daniel Kennefick: Traveling at the Speed of Thought  

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h a p t e r 1 Figure 1.1. The LIGO facility at Hanford, Washington, one of two separate detec tors beam tubes down which lasers are fired and bounced back and forth by high-quality mirrors. Any changes

Landweber, Laura

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241

Pinole Creek Watershed Sediment Source Assessment: A sediment budget approach highlighting watershed-scale sediment-related processes and supply to the Bay  

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Pinole Creek Watershed Sediment Source Assessment: A sediment budget approach highlighting watershed-scale sediment-related processes and supply to the Bay Pearce,S.1 ,McKee,L.1 ,Arnold,C.2 ,and,landowners,stakeholders,agencies and regula- tors are facing many watershed-scale sediment-related issues such as erosion,degraded water

242

Trends in Climatology  

Science Journals Connector (OSTI)

...ac-cumulating from Texas Towers offshore, but a climatological...westerly component of the wind in meters per second in...indicate prevailing easterly winds. Left section shows values...They cause the trade winds, the westerlies, the...fac-tor is important in farm management and irrigation...

H. E. Landsberg

1958-10-03T23:59:59.000Z

243

Green functors Recall that the letter R denotes a commutative and associative ring with  

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Green functors Recall that the letter R denotes a commutative There are (at least) two equivalent definitions of Green functors for G over R. 1.1. Using the poset of subgroups of G. This definition of Green func- tors uses the poset of subgroups of G. It goes back to Green

Bouc, Serge

244

Analysis of Seismic Activity near Theodore Roosevelt Dam, Arizona, during the Occupation  

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E Analysis of Seismic Activity near Theodore Roosevelt Dam, Arizona, during the Occupation, and Lepolt Linkimer Online Material: Plot of viable focal mechanisms and table of regional seismic velocity model. INTRODUCTION Rate and distribution of seismic activity are important indica- tors of the overall

Fouch, Matthew J.

245

Resolving the Electron Transfer Kinetics in the Bacterial Reaction Center by Pulse Polarized 2-D Photon Echo Spectroscopy  

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, restricting their use in flexible optoelectronic devices.4 In addition, the limited availability of indium that can work as transparent conduc- tors for future optoelectronic devices. The question arises: what American Chemical Society The next generation of optoelectronic devices requires transparent conductive

Mukamel, Shaul

246

Changes in Soil Physical Properties Due to Organic Waste Applications: A Review1 R. KHALEEL, K. R. REDDY, AND M. R. OVERCASH2  

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. REDDY, AND M. R. OVERCASH2 ABSTRACT Land application of organic wastes such as animal manure, munici- pal wastes, and sewage sludge could alter the soil physical properties. Repeated substantial). Several investiga- tors, in monitoring runoff water quality from small plot-sized land application areas

Florida, University of

247

Low loss liquid crystals for infrared applications Fenglin Penga  

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contender for phase modulation, such as spatial light modula- tors (SLMs),[1] laser beam steering,[2-free LC device is governed by: T � exp��,� (2) where stands for the absorption coefficient at a laser as a cladding layer, and only about 10% of the evanescent beam penetrates into the LC layer. Therefore

Wu, Shin-Tson

248

The Hitchhiker's Guide to Successful Residential Sensing Deployments  

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with information about people's energy consumption, medical health, and personal or family func- tions, Smart Homes, Sensor Networks 1 Introduction On average, Americans spend 65% of their time in their own) are valuable indica- tors of health. Homes also constitute a large fraction of the carbon and energy footprint

Whitehouse, Kamin

249

DESIGN REQUIREMENTS AND OPTIONS FOR FINAL FOCUSING SUPERCONDUCTING MAGNETS  

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of using both high-temperature superconductors and con- ventional low-temperature superconductors and operated in particle accelera- tors!. It should be mentioned that before high-temperature superconductor are investi- gated. The use of high-temperature superconducting materials may offer an attractive, although

California at San Diego, University of

250

QED3 Theory of High Temperature Superconductors  

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QED3 Theory of High Temperature Superconductors Zlatko Tesanovi´c The Johns Hopkins University is The Problem in high Tc superconductors? · Superconducting state appears dx2-y2 "BCS-like". Low energy: · Today, everything seems to be a high temperature superconduc- tor (cuprates, C60's, MgB2

Tesanovic, Zlatko

251

Nano in Cancer: Linking Chemistry, Biology, and Clinical Applications In Vivo  

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...2013; Boston, MA Abstract C200: Rapid nano-immunoassay for evaluation of mTOR pathway...phosphorylation states. We have used this novel nano-technology based system to study the...corroborated by the NanoPro assay. This nano-immunoassay was able to reliably quantify...

Robin S Dothager and David Piwnica-Worms

2011-09-01T23:59:59.000Z

252

DOI: 10.1002/chem.200802066 Photoinduced Intramolecular Macrocyclization Reaction between a Bpa and  

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DOI: 10.1002/chem.200802066 Photoinduced Intramolecular Macrocyclization Reaction between a Bpa,[b] and Claudio Toniolo*[a] The 3-(4-benzoylphenyl)alanyl (Bpa) residue has been ex- tensively used as a probe diastereomeric products. In actual ligand­recep- tor studies the preferential selectivity of Bpa for Met over all

Leigh, William J.

253

Developmental Cell 11, 859871, December, 2006 2006 Elsevier Inc. DOI 10.1016/j.devcel.2006.10.007 Ablation in Mice of the mTORC Components raptor,  

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Department of Biology 9 Cambridge Center Cambridge, Massachusetts 02141 2 Center for Cancer Research is deter- mined by unique mTOR-interacting proteins. mTORC1 controls cell growth in part by phosphorylating), which regulates cell proliferation, growth, survival, and metabolism. Full activation of Akt

Sabatini, David M.

254

Collective dynamics of Josephson fluxons in Bi2Sr2CaCu2O8d intrinsic junctions  

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in naturally stacked intrinsic Josephson junctions in Bi2Sr2- CaCu2O8þd single crystals were studied Keywords: Fluxon dynamics; Intrinsic Josephson junctions; Plasma excitation modes; Superradiant state 1 to high-frequency devices such as THz local oscilla- tors and mixers. Stacked long Josephson junctions

Lee, Hu-Jong

255

2012 by the American Academy of Arts & Sciences Is Shale Gas Good for Climate Change?  

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- ence and Engineering at Harvard University, where he is also Direc- tor of the Center for the Environ fracturing ("fracking") techniques that greatly increase the permeability of the shale, vast reserves emissions overall. I argue that the main impact of shale gas on climate change is neither the reduced

Schrag, Daniel

256

National Heart, Lung, and Blood Institute  

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National Heart, Lung, and Blood Institute A T - A - G L A N C E : What You Need To Know About High- tors for heart disease. In fact, the higher your blood cholesterol, the greater your risk of developing heart disease or having a heart attack. Heart disease is the #1 killer of men and women in the United

Bandettini, Peter A.

257

>H SlOOOlolo NiNOVEMBER 1986  

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(VTT) Risø National Laboratory, Denmark Institute for Energy Technology, Norway (IFE) The Swedish State- energy #12;u Nordisk Mordiska Pohjoismainen Nordic kontaktorgan tor kontaktorganet Hr »miieimijii liaisoncornrnMee for atornenergtspergsmil atornenergrtr&oor yhdysain atomic energy

258

THE CHALLENGE IN FINDING LONG-TERM LUBRICATION solutions for wind turbines  

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THE CHALLENGE IN FINDING LONG-TERM LUBRICATION solutions for wind turbines is well known wind turbines in a farm in order to improve their longevity. In a previous TLT article, research- ers used a technique known as Simula- tor for Offshore /Onshore Wind Farm Applications to examine

Chiao, Jung-Chih

259

FINANCIAL RepoRt201011 A NEw LEAdEr fOr ThE UNivErSiTy | 36  

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ESpONSibiLiTy LETTEr | 51 iNdEpENdENT AUdiTOr'S OpiNiON | 52 STATEMENT Of NET ASSETS | 53 COMpONENT UNiTS COMbi is essential to my role in helping to coordinate resources and energy in support of those goals. I

Acton, Scott

260

Z .Mechanics of Materials 28 1998 227236 Adiabatic shearband in WHA in high-strain-rate compression  

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, the deformation of a Z .conventional depleted uranium DU penetrator quickly localizes into intense adiabatic of the impacting face of the penetra- tor. Therefore, the uranium projectile is an efficient penetrator. The DU however, causes health hazards. There is, therefore, a need to replace the DU penetra- Ztors

Nemat-Nasser, Sia

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261

Optimization of experimental design in fMRI: a general framework using a genetic algorithm  

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Optimization of experimental design in fMRI: a general framework using a genetic algorithm Tor D uses a genetic algorithm (GA), a class of flexible search algorithms that optimize designs with respect with respect to fitness criteria, allowing optimization over known or novel fitness measures. We describe how

262

VOLUME 86, NUMBER 6 P H Y S I C A L R E V I E W L E T T E R S 5 FEBRUARY 2001 Multiple Andreev Reflections Revealed by the Energy Distribution of Quasiparticles  

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recently has been shown to describe in great detail the current-voltage characteristics [7], the noise [8 are sym- metrical with regard to the electrochemical potential of the superconductor. When two and quasiholes at symmetrical energies about the electrochemical potential m of the superconduc- tor is equal

Devoret, Michel H.

263

HUMAN GENE THERAPY 16:299306 (March 2005) Mary Ann Liebert, Inc.  

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HUMAN GENE THERAPY 16:299­306 (March 2005) © Mary Ann Liebert, Inc. Modified Infusion Procedures expression was equal with hepatic artery and portal vein infusion, which was higher than vector administered via peripheral venous infusion. Next, we determined how localized perfusion or changing the vec- tor

Ford, James

264

Molecular Plant Pages 110, 2011 RESEARCH ARTICLE Catabolism of Branched Chain Amino Acids  

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Horticultural Sciences Department and the Plant Molecular & Cellular Biology Program, University of Florida of branched chain amino acid transaminases 1 and 3, evaluating the rates of respiration in fruits deficient of the rapamycin (mTOR) pathway, in part, by serving both as a mitochondrial fuel through oxidative carboxylation

Klee, Harry J.

265

Whole-genome random sequencing and assembly of Haemophilus influenzae Rd  

Science Journals Connector (OSTI)

...70 90 Anaerobic 71 1047 anaerobic DMSO RDase A (dmsA)1046 anaerobic DMSO RDase B (dmsB) 1045 anaerobic DMSO RDase C (dmsC)58 0644 cytochrome C-type prt (torC)72 0348 denitrification system component (nirT)84 0009 formate DHase pathway prt...

RD Fleischmann; MD Adams; O White; RA Clayton; EF Kirkness; AR Kerlavage; CJ Bult; JF Tomb; BA Dougherty; JM Merrick; et al.

1995-07-28T23:59:59.000Z

266

Whole-genome random sequencing and assembly of Haemophilus influenzae Rd  

Science Journals Connector (OSTI)

...anaerobic DMSO RDase B (dmsB) 1045 anaerobic DMSO RDase C (dmsC)58 0644 cytochrome C-type prt (torC)72 0348 denitrification...58 57 61 67 56 58 Colicin-related functions 0382 colicin tolerance prt (tolB) 78 1206 colicin V production prt (cvpA) 79 0384...

RD Fleischmann; MD Adams; O White; RA Clayton; EF Kirkness; AR Kerlavage; CJ Bult; JF Tomb; BA Dougherty; JM Merrick; et al.

1995-07-28T23:59:59.000Z

267

Aerosol delivery of beclin1 enhanced the anti-tumor effect of radiation in the lungs of K-rasLA1 mice  

Science Journals Connector (OSTI)

......similar effects to using mTOR inhibitors (Fig.-3b, c). Akt1...Urocanic acid-modified chitosan-mediated PTEN delivery via...aerosol-delivered folate-chitosan-graft-polyethylenimine...Z-VAD, a pan-caspase inhibitor. Mol Cancer Ther (2009......

Ji-Young Shin; Hwang-Tae Lim; Arash Minai-Tehrani; Mi-Suk Noh; Ji-Eun Kim; Ji-Hye Kim; Hu-Lin Jiang; Rohidas Arote; Doo-Yeol Kim; Chanhee Chae; Kee-Ho Lee; Mi-Sook Kim; Myung-Haing Cho

2012-07-01T23:59:59.000Z

268

Black phosphorus field-effect transistors Likai Li1, Yijun Yu1, Guo Jun Ye2, Qingqin Ge1, Xuedong Ou1, Hua Wu1, Donglai Feng1, Xian Hui Chen2  

E-Print Network (OSTI)

nanometres. Reliable transistor performance is achieved at room temperature in samples thinner than 7.5 nm in the infrared regime. In addition, observations of a phase transition from semiconduc- tor to metal14-layer phosphorene FETs with a backgate electrode (Fig. 2a). A scotch tape-based mechanical exfoliation method

Cai, Long

269

NATIONAL RADIO ASTRONOMY OBSERVATORY GREEN BANK, WEST VIRGINIA  

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information on the cooled ortho-mode transition, and Section IV contains drawings, schematics, and wiring, designed for mounting in the prime focus Sterling mount. The FEB is equipped with eight thermoelectric- tor/control chassis, four RF modules, and six printed circuit card slots. The feeds are dual mode

Groppi, Christopher

270

Gordon Research Conferences  

Science Journals Connector (OSTI)

...Mutations and Human Aging." Import and Assembly...this Process." Nuclear Control of Organelle...R. Scarpulla, "Nuclear Respiratory Fac-tors...Phenomena-Physico-Chemical Interactions: K...R. Behringer, "Nuclear Magnetic Reso-nance...Equation and Aver-aging." R. Lenormand...

Carlyle B. Storm

1994-02-18T23:59:59.000Z

271

CSRI Senior Fellows Simon Zadek and Salil  

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concerning some of society's most challenging problems at the interface of the public and private sec- tors that are at once intellectually rigorous and policy relevant. PROGRAMS ENERGY & ENVIRONMENT HARVARD ELECTRICITY to a more competitive electricity market, provides a forum for informed and open debate, and supplies

Gunawardena, Jeremy

272

The Conspiracy  

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, "":!ho sale 'i'c=ay Zi mmcm .;: his las t fix?" Fr eddie panicked , "I don't kno\\'/ ?,'!hat you 'rc tCllking about ! I cion ' t knot! any Tommy Sil:l!l1on:: !" ,ro bust ... ti you sive us the right informat ion ??? \\lho so l Tor.'lmY .3::'!!Imons his...

Meier, Cheryl; Cribb, Lucy

1981-01-01T23:59:59.000Z

273

Rebound Effects in Sustainable HCI Samuel J. Kaufman  

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or water consumption) may be poor indica- tors of such systems' effect on emissions because of effects, or energy efficiency technology [4], is: 1. SHCI researchers make information systems (devices, phone. This research has shown promis- ing results. However, the proxies generally used in evaluation (e.g. less energy

Anderson, Richard

274

2,3,7,8-Tetrachlorodibenzo-p-dioxin Inhibits Zebrafish Caudal Fin Regeneration  

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2,3,7,8-Tetrachlorodibenzo-p-dioxin Inhibits Zebrafish Caudal Fin Regeneration Jeanmarie M. Zodrow- chlorodibenzo-p-dioxin (TCDD). Zebrafish caudal fins were par- tially amputated, and the fish received. Key Words: zebrafish; fin regeneration; aryl hydrocarbon recep- tor; AHR; 2,3,7,8-tetrachlorodibenzo-p-dioxin

Tullos, Desiree

275

Threats in the Tienshan-Pamir Region of Kyrgyzstan  

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There are two extremely dangerous warehouse or tailings areas in TienShan. The first one is due to cyanide contained in waste from gold mining in the Kum-Tor area, 4,100 above sea level. The Petrov-Davidov Glacie...

I. Hadjamberdiev; V. Shablovsky; V. Ponomarev

2009-01-01T23:59:59.000Z

276

Simulation Vector Generation from HDL Descriptions for ObservabilityEnhanced Statement Coverage  

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generated. For vector generation, we proposea novel technique to set up constraints basedon the cho­ sen generation, and the size of the generated vec­ tor set. However, the most important step here is to helpSimulation Vector Generation from HDL Descriptions for Observability­Enhanced Statement Coverage

Devadas, Srinivas

277

Plastik schneidern Chemiker heute nach Ma: Sie haben Polymere zu versierten  

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Mülheimer Institutsdirek- tor den Nobelpreis für Chemie. Allerdings musste er sich die Auszeichnung mit dem weiter.Am 10. Dezember 1963 erhielten Ziegler und Natta den Nobelpreis für Chemie aus den Händen Königs

278

PDGF Receptor Alpha Is an Alternative Mediator of Rapamycin-Induced Akt Activation: Implications for Combination Targeted Therapy of Synovial Sarcoma  

Science Journals Connector (OSTI)

...phase 2 study of temsirolimus (CCI-779) in patients with soft tissue sarcomas: a study of the Mayo phase 2 consortium (P2C).Cancer 2011;117:3468-75. 11. O'Reilly KE , Rojo F, She QB, Solit D, Mills GB, Smith D, et almTOR inhibition...

Alan L. Ho; Shyamprasad Deraje Vasudeva; Marick Laé; Tsuyoshi Saito; Violetta Barbashina; Cristina R. Antonescu; Marc Ladanyi; Gary K. Schwartz

2012-09-01T23:59:59.000Z

279

journal homepage: www.elsevier.com/locate/nanoenergy Available online at www.sciencedirect.com  

E-Print Network (OSTI)

; Flexible Abstract Harvest mechanical energy with variable frequency and amplitude in our environment can reach as high as$4.125 mW by a finger typing, which is high enough to instantaneously drive 50 nanogenera- tors (TENGs) [17­20] have been developed to harvest irregular mechanical energy with variable

Wang, Zhong L.

280

Copyright 1998 Psychonomic Society, Inc. 76 Colonies of Norway rats (Rattus norvegicus) in large  

E-Print Network (OSTI)

so may allow rats to find food efficiently. Other fac- tors that could have favored path following these traits al- lowed rats to orient in the environment and to economi- cally gather food from spatially separated food patches. Empirical support for the hypothesis that rats can use paths to economically forage

Timberlake, William D.

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281

1997 IEEE International Symposium ow Circuitsand Systems, June 9-12,1997, Hong Kong A Logarithmic Photoreceptor Incorporating Lateral Bipolar  

E-Print Network (OSTI)

. Rowley, Member, IEEE, John G. Harris, Member, IEEE, and Shao-Jen Liin, Member, IEEE Abstract: Offsets will discuss a new continuous-time, logarithmic photoreceptor which is based on Mead's original recep- tor [l] but achieves a better signal-to-offset mtio and a larger dynamic range. Mead's original receptor has been used

Harris, John G.

282

Tunable Fano resonances based on two-beam interference in microring Ting Hu, Ping Yu, Chen Qiu, Huiye Qiu, Fan Wang et al.  

E-Print Network (OSTI)

The transmission spectrum of a single microring resona- tor (MRR) typically exhibits symmetric Lorentz line shape. But if, University of Nevada, Las Vegas, Nevada 89154, USA (Received 9 November 2012; accepted 17 December 2012 improved compared to the counterpart with symmetric line shape. Based on this model, Chao and Guo

Yang, Mei

283

Fuel Cell-Shaft Power Packs (FC-SPP) Frank Elefsen, Centre Manager, Ph.D., and Sten Frandsen, Head of Section  

E-Print Network (OSTI)

technology is receiving a great deal of attention. Hydrogen and fuel cells have the potential to replace and the transportation sector. To promote this synergy, there is a strong need to illustrate hydrogen and fuel cell, a fuel cell, and an electrical mo- tor (Fuel Cell-Shaft Power Pack). The hydrogen will mostly come from

284

Atmos. Chem. Phys., 14, 46074616, 2014 www.atmos-chem-phys.net/14/4607/2014/  

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the atmospheric dispersion of radionuclides by nuclear power plant accidents in the coming decades T. Christoudias and atmospheric dispersion of radionuclides from nuclear power plant accidents using the EMAC atmospheric chemistry­ general circulation model. We included all nuclear reac- tors that are currently operational

Meskhidze, Nicholas

285

Abstract--We have recently completed a large-area, coded-aperture, gamma-ray imager for use in searching for radiation  

E-Print Network (OSTI)

Abstract-- We have recently completed a large-area, coded- aperture, gamma-ray imager for use. The in- strument uses a rank-19, one-dimensional coded aperture to cast shadow patterns onto a 0.57 m2 Na sufficient radiation can reach a large gamma-ray detec- tor from a small source to make detection possible

Horn, Berthold K.P.

286

2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim 1 www.advmat.de  

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limita- tions of traditional power supplies by providing a supplemen- tary electric power source appliances, such as washing machines and refrigera- tors, to bouncing automobile tires on a gravel road harvesting have been limited to transductions based on piezo- electric effect,[1­5] electromagnetic effect,[6

Wang, Zhong L.

287

IEEE TRANSACTIONS ON CONTROL SYSTEMS TECHNOLOGY, VOL. 15, NO. 6, NOVEMBER 2007 1065 Robust Optimal Design of Unstable Valves  

E-Print Network (OSTI)

and outer radii of the valve chamber; and 3) the nonmetering orifice momentum flux coefficient which Design of Unstable Valves QingHui Yuan, Member, IEEE, and Perry Y. Li, Member, IEEE Abstract--This paper of electrohydraulic valves. Currently, limitations of solenoid actua- tors have prevented single stage

Li, Perry Y.

288

Modeling the fiansitory Behavior of Speech Using a Time-varying Transmission-line Model Amit S. Rane, Derrick C. Wei, Lisa E, Falkson, and Abeer A. Alwan  

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Modeling the fiansitory Behavior of Speech Using a Time-varying Transmission-line Model Amit S. Abstract: In this study, a transmission-line model of speech production (1) is modified so that changes equivalent transmission line comprising Resis- tors (R), Capacitors (C), and Inductors (L). A radiation

Alwan, Abeer

289

JOURNALDE PHYSIQUE ColloqueC6,suppl6ment au nOll,Tome 48,novembre 1987  

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transmission line using an oil condenser of 120kV-0.15~. a high speed impulse switching system with a time for condenser charging voltages of 50 to 120kV and peak currents of 20 to 40kA. The maximum intensities genera- tor, a simple low impedance transmission line with a high voltage coaxial oil condenser

Paris-Sud XI, Université de

290

Similar Structures and Shared Switch Mechanisms of the 2-Adrenoceptor and the Parathyroid Hormone Receptor  

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experiments that define distance constraints between specific positions in individual helices can test- tors comprise a conserved switch that relays signals from extracellular stimuli to heterotrimeric G molecules that relay extracellular signals from hormones and sensory stimuli to heterotrimeric G proteins

Lichtarge, Olivier

291

An Implicit Optimization Approach for Survivable Network Design  

E-Print Network (OSTI)

heavily on networked systems such as the electric power grid, water and gas distribution systems, com networks. For example, nodes can represent genera- tors, load points, and junctions in a power system capacities) even after the disruption of a subset of the network's arcs. Specifically, we consider the case

Pinar, Ali

292

Product sound: Acoustically pleasant motor drives  

E-Print Network (OSTI)

the framework of the Danish PhD Research school EnergyLab DK. The project is entitled Project sound noise generated by electrical mo- tors driven by a pulse width modulated (PWM) power electronic inverter analytical solution is proposed. The proposed unified analytical solution can be used for most of the carrier

Mathe, Laszlo

293

24 ENGINEERING & SCIENCE fall 2012 25fall 2012 ENGINEERING & SCIENCE  

E-Print Network (OSTI)

biochemist Arie Haagen-Smit, known as the father of air-pollution control, in the lab. Below: John Seinfeld research focuses on the control of air pollutants. "The b. a 30-Billion-Ton rEacTor Before Caltech biochemist Arie haagen-Smit started working on the air-pollution

294

ARMresearch_highlights.indd  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiosonde Comparisons Improve Humidity Data * Computing Radiative Transfer More Effectively * For Ice Particles, Size and Shape Do Matter * The Fade Fac- tor: Modeled vs. Measured DNSI CONTENTS December 2003 Atmospheric Radiation Measurement Program ARM CONTENTS Tropical Radiosonde Comparisons Improve Past and Present Humidity Data The Atmospheric Radiation Measurement (ARM) Program's

295

On the Design of Shape Memory Alloy Wire Bundle Actuators Kathryn J. De Laurentis1  

E-Print Network (OSTI)

the use of compact, smart material based actuators to power the robot joints [1]. Smart materials alter memory alloys and polymers are examples of smart materials. The interest in these types of actuators one of the highest payload to weight ratios among "smart material" based actua- tors. Therefore, SMAs

Mavroidis, Constantinos

296

Washout Filter Design for a Motorcycle Simulator Federico Barbagli, Diego Ferrazzin, Carlo Alberto Avizzano, Massimo Bergamasco  

E-Print Network (OSTI)

Washout Filter Design for a Motorcycle Simulator Federico Barbagli, Diego Ferrazzin, Carlo Alberto present a washout filter designed for a motorcycle simula- tor. The solution is preliminary and follows motorcycle and aircraft simu- lation are analyzed and a preliminary customized solution is proposed

Barbagli, Federico

297

NSF GRANT # 0448730 NSF PROGRAM NAME: Civil, Mechanical and Manufacturing Innovation  

E-Print Network (OSTI)

-Angle Rigid Body Dynamics of a Floating Offshore Wind Turbine using Euler's Equations of Motion Bert Sweetman to support offshore wind turbines in deep water, where environmental forcing could subject the ro- tor, aesthetic and political pressures continue to push for siting offshore wind turbines beyond sight of land

Sweetman, Bert

298

The Plant Cell, October 2009, www.plantcell.org 2009 American Society of Plant Biologists TEACHING TOOLS IN PLANT BIOLOGY  

E-Print Network (OSTI)

that frequently they no longer resemble their wild ances- tors. A cultivated field of any of our major crops to con- vert the energy from sunlight into chemi- cal energy has allowed plants to occupy a niche from grains, primarily rice, wheat, and corn, as well as some leg- umes. We grow our crops in areas

Bauwe, Hermann

299

EPA-600/4-82-061 DOE/DP/00539-046  

Office of Legacy Management (LM)

EPA-600/4-82-061 EPA-600/4-82-061 DOE/DP/00539-046 August 1982 OFFSITE ENVIRONMENTAL MONITORING REPORT R a d i a t i o n m o n i t o r i n g around U n i t e d States n u c l e a r t e s t areas, c a l e n d a r y e a r 1981 compiled by S. C. Black, R. F. Grossman, A . A . Mullen, G. D. P o t t e r and D. D. Smith Envi ronmental M o n i t o r i n g Systems Laboratory Las Vegas, Nevada 89114 and J. L. Hopper Reynolds E l e c t r i c a l & Engineering Company, Inc. Las Vegas, Nevada 89102 prepared f o r t h e 1J.S. Department o f Energy under Mernorandum o f Understanding Number DE-AI08-76DP00539 ENVIRONMENTAL MONITORING SYSTEMS LABORATORY OFFICE OF RESEARCH AND DEVELOPMENT U.S..ENVIRONMENTAL PROTECTION AGENCY LAS VEGAS, NEVADA 89114 DISCLAIMER T h i s r e p o r t has been reviewed i n accordance w i t h t h e U.S. Environmental P r o t e c t i o n Agency ' s peer and admi n

300

Arizona RECORD OF CATEGORICAL EXCLUSION DETERMINATION  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

tor the addition ot bird tor the addition ot bird diversion equipment along the existing Prescott-Pinnacle Peak 230-kV transmission line right-ot-way located in Yavapai County, Arizona . RECORD OF CATEGORICAL EXCLUSION DETERMINATION A. Proposed Action: Western proposes installing Firefly type bird diversion equipment onto static wires (overhead ground wires) of the Prescott-Pinnacle Peak 230-kV transmission line between structures 144/3 and 145/2. The diverters will be spaced approximately 15 ft apart alternating between the two static lines. The diverters will be installed using a hot stick from a helicopter or by accessing the line using existing access roads and rubber-tired vehicles such as cherry pickers, pickup trucks, crew trucks. All work will be done within Westerns existing right-of-way. This

Note: This page contains sample records for the topic "admi nistra tor" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Mr. Jack W. Anderson Chief Operating Officer Fermilab  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

~y ~y ,~ !l` ~; Mr. Jack W. Anderson Chief Operating Officer Fermilab P.O. Box 500 Batavia, IL 60510 Dear Mr. Anderson: SUBJECT: NATIONAL ENVIRONM ENTAL POLICY ACT (NEPA) DETERMIN ATION AT FERMI NATIONAL ACCELERA TOR LABORATO RY (FERMILAB ) - NORTHERN ILLINOIS CENTER FOR ACCELERA TOR AND DETECTOR DEVELOPM ENT (NICADD) EXTRUSIO N LINE FACILITY Reference: Letter, from J. Anderson to M. Weis, dated February 13, 2013, Subject: NEPA Environment al Evaluation Notification Form (EENF) for the NICADD Extrusion Line Facility have reviewed the Fermilab EENF for the NICADD Extrusion Line Facility. Based on the information provided in the EENF, I have approved the following categorical exclusion (CX): Project Name A~groved CX NICADD Extrusion Line Facility 2/20/2013 B1.15 am returning a signed copy of the EENF for your records. No further NEPA review is required.

302

LCC-0023 cover.PDF  

NLE Websites -- All DOE Office Websites (Extended Search)

3 31/08/99 3 31/08/99 Matching Program for the NLC Main Linac August 31, 1999 Yuri Nosochkov, Tor Raubenheimer and Mark Woodley Stanford Linear Accelerator Center Stanford, California Abstract: In this note, we describe the computer code used to design the NLC main linac optics, and present the current parameters of the linac lattice. Matching Program for the NLC Main Linac Yuri Nosochkov, Tor Raubenheimer and Mark Woodley Stanford Linear Accelerator Center, Stanford University, Stanford, CA 94309 Abstract In this note, we describe the computer code used to design the NLC main linac optics, and present the current parameters of the linac lattice. 1 Introduction The two main components of the linac are accelerator structures for beam acceleration and quadru- poles for transverse focusing. Most of the NLC linac length is occupied by the accelerator

303

Browse by Discipline -- E-print Network Subject Pathways: Physics --  

Office of Scientific and Technical Information (OSTI)

Engineering Engineering Go to Research Groups Preprints Provided by Individual Scientists: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Aamodt, Tor (Tor Aamodt) - Department of Electrical and Computer Engineering, University of British Columbia Aazhang, Behnaam (Behnaam Aazhang) - Department of Electrical and Computer Engineering, Rice University Abate, Alessandro (Alessandro Abate) - Faculty of Mechanical, Maritime and Materials Engineering, Technische Universiteit Delft Abbott, Derek (Derek Abbott) - School of Electrical and Electronic Engineering, University of Adelaide Abdallah, Chaouki T(Chaouki TAbdallah)T- Electrical and Computer Engineering Department, University of New Mexico Abdel-Malek, Karim (Karim Abdel-Malek) - Departments of Biomedical

304

Browse by Discipline -- E-print Network Subject Pathways: Materials Science  

Office of Scientific and Technical Information (OSTI)

Computer Technologies and Information Sciences Computer Technologies and Information Sciences Go to Research Groups Preprints Provided by Individual Scientists: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Aalst, W.M.P.van der (W.M.P.van der Aalst) - Wiskunde en Informatica, Technische Universiteit Eindhoven Aamodt, Agnar (Agnar Aamodt) - Department of Computer and Information Science, Norwegian University of Science and Technology Aamodt, Tor (Tor Aamodt) - Department of Electrical and Computer Engineering, University of British Columbia Aardal, Karen (Karen Aardal) - Centrum voor Wiskunde en Informatica Aaronson, Scott (Scott Aaronson) - Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT) Aazhang, Behnaam (Behnaam Aazhang) - Department of Electrical and

305

NVO··90  

NLE Websites -- All DOE Office Websites (Extended Search)

NVO··90 NVO··90 * JlH\~E 1973 UNITED STATES ATf)NUC t::NERGY COb/tIVUSSiON NEVi~DA OPERATI()NS OFfICE las Vo~)as, t-Jovoda ---------.., lFIED UNCLASSIFIED SEP 24 19W .4:J~~~~'!f!1:;-- Date DISCLAIMER Portions of this document may be illegible in electronic image products. Images are produced from the best available original document. NO TIC E This report was prepared as an account of work sponsored by the United States Government. Neither the United States, nor the United States Atomic Energy Commission, nor any of their employees, nor any of their contra~tors, subcontrac- tors, or their employees, makes any warranty, expressed or implied, or assumes any legal liability or responsibility for the accuracy, completeness or usefulness of any infor- mation, apparatus, product or process disclosed,

306

Browse by Discipline -- E-print Network Subject Pathways: Computer  

Office of Scientific and Technical Information (OSTI)

Computer Technologies and Information Sciences Computer Technologies and Information Sciences Go to Research Groups Preprints Provided by Individual Scientists: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Aalst, W.M.P.van der (W.M.P.van der Aalst) - Wiskunde en Informatica, Technische Universiteit Eindhoven Aamodt, Agnar (Agnar Aamodt) - Department of Computer and Information Science, Norwegian University of Science and Technology Aamodt, Tor (Tor Aamodt) - Department of Electrical and Computer Engineering, University of British Columbia Aardal, Karen (Karen Aardal) - Centrum voor Wiskunde en Informatica Aaronson, Scott (Scott Aaronson) - Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT) Aazhang, Behnaam (Behnaam Aazhang) - Department of Electrical and

307

Browse by Discipline -- E-print Network Subject Pathways: Engineering --  

Office of Scientific and Technical Information (OSTI)

Engineering Engineering Go to Research Groups Preprints Provided by Individual Scientists: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Aamodt, Tor (Tor Aamodt) - Department of Electrical and Computer Engineering, University of British Columbia Aazhang, Behnaam (Behnaam Aazhang) - Department of Electrical and Computer Engineering, Rice University Abate, Alessandro (Alessandro Abate) - Faculty of Mechanical, Maritime and Materials Engineering, Technische Universiteit Delft Abbott, Derek (Derek Abbott) - School of Electrical and Electronic Engineering, University of Adelaide Abdallah, Chaouki T(Chaouki TAbdallah)T- Electrical and Computer Engineering Department, University of New Mexico Abdel-Malek, Karim (Karim Abdel-Malek) - Departments of Biomedical

308

Chemical screening platforms for autophagy drug discovery to identify therapeutic candidates for Huntington's disease and other neurodegenerative disorders  

Science Journals Connector (OSTI)

Autophagy is a cellular degradation process involved in the clearance of aggregate-prone proteins associated with neurodegenerative diseases. While the mTOR pathway has been known to be the major regulator of autophagy, recent advancements into the regulation of autophagy have identified mTOR-independent autophagy pathways that are amenable to chemical perturbations. Several chemical and genetic screens have been undertaken to identify small molecule and genetic regulators of autophagy, respectively. The small molecule autophagy enhancers offer great potential as therapeutic candidates not only for neurodegenerative diseases, but also for diverse human diseases where autophagy acts as a protective pathway. This review highlights the various chemical screening platforms for autophagy drug discovery pertinent for the treatment of neurodegenerative diseases.

Sovan Sarkar

2013-01-01T23:59:59.000Z

309

The influence of iodinated casein and high fat diets on the performance and incidence of fatty livers in laying hens  

E-Print Network (OSTI)

&iocasein caused no chango in egg p"eduction i&i&en fc&3 by (?itt&. ridge and Novi!&off (1&347), . &ilson (1&34&3) and Iianson and Smyth (1'355) at 200 grims per tor. . -gg production w:is not affected wTi &n iodinai, =d ca cirl w'is f&'d b) oillie et al...&iocasein caused no chango in egg p"eduction i&i&en fc&3 by (?itt&. ridge and Novi!&off (1&347), . &ilson (1&34&3) and Iianson and Smyth (1'355) at 200 grims per tor. . -gg production w:is not affected wTi &n iodinai, =d ca cirl w'is f&'d b) oillie et al...

Young, Louis Lee

2012-06-07T23:59:59.000Z

310

Further fractionation studies on unidentified growth factors in distillers dried solubles  

E-Print Network (OSTI)

J. ?ro:&th f:&c oro. 'ev. ". ~1 labor. tor. i. ;. . ucv", utt . n?te. ' to 1. &cia:. o &'J m g' a ?. , uniko'&. '1 & iel "r3, i & f ' 0 "o . . r . & & n & ural eources ~ '&ovM . ZQ1 . Iau;9, . -'3) le . c &. '3, ? ' t 1e;r3 &9rt &. oo?f & f 3 'tor 1...ounl in 1 till r irioz uol ' 1 . . ~ fh& 1' gc' o; ', ', ':tahle o hoot, =":. ' ani . lkzli; olu)lo in =&her, e. . &ol ter ut . il lg 1'f oren-' &'. ! v. lu&; reci i . te i hg, shoal &otun- c c &cia &mt 1 . i &ce uto. I;; . : ot , . rhcJ. on fuller...

Rozacky, Eugene Emil

2012-06-07T23:59:59.000Z

311

A review of "History of Ukraine-Rus’: Economic, Cultural, and National Life in the Fourteenth to Seventeenth Centuries" by Mykhailo Hrushevsky  

E-Print Network (OSTI)

253 seventeenth-century news Mykhailo Hrushevsky. History of Ukraine-Rus’ Vol. 6: Economic, Cultural, and National Life in the Fourteenth to Seventeenth Centuries. Translated by Leonid Heretz. Myron M Kapral, Consulting Editor and Frank E Sysyn... cited by Hrushevsky, two appendixes, and a comprehensive index have also been provided for the reader’s benefit. Prof. Frank E. Sysyn, direc- tor of the Petro Jacyk Central and East European Resource Centre, remains the series editor, assisted...

Stevens, Carol B.

2014-01-01T23:59:59.000Z

312

Fundamentals of phase-only liquid crystal on silicon (LCOS) devices  

E-Print Network (OSTI)

are usually called LCOS spatial light modulators (SLMs). The architecture of LCOS devices is similar to conventional LC devices except that a silicon backplane constitutes one of the substrates (Figure 1). The silicon CMOS backplane consists of the electronic... transform processors make the holographic projection technology a practical proposition. Alps Electric UK and Light Blue Optics95 are two companies currently developing holographic projec- tors, automotive head-up displays, interactive projectors, etc...

Zhang, Zichen; You, Zheng; Chu, Daping

2014-10-24T23:59:59.000Z

313

1990 AAAS Annual Meeting New Orleans, 15-20 February  

Science Journals Connector (OSTI)

...assessment and perception. Douglas...of medical practice; health...HUGO; ethical, moral...alternatives; perspectives. B. Taylor...impacts; social costs; bidding...silicon theory. Mary L...string theory; minimal...Methods in the Social Sciences...and Public Perceptions (Mon/am...Evolu-tionary Perspective (Frilpm...training; gender difference. John Casterline...university roles; preda-tors...ventures; business; basic research...

1989-12-08T23:59:59.000Z

314

Universidade de Braslia Decanato de Ensino de Graduao  

E-Print Network (OSTI)

CEG Prof.º Marcelo Carvalho Rosa - Representante da CPP Rodrigo Garcia Vieira Braz - Representante dos Eduarda Silva Costa Custódio Graduação MATEMÁTICA Adail de Castro Cavalheiro Vítor da Silva Santos Carvalho de Andrade e Demétrio A. da Silva Filho Paulo Henrique Brener dos Santos Graduação FÍSICA Vanessa

Lucero, Jorge Carlos

315

Discussion on the Water-Saving Technology of the Green Community  

E-Print Network (OSTI)

water utilization. Key words: green building; life cycle assessment (LCA); green community; non-traditional water resource; terms of reference (TOR) 1. INTRODUCTION Many countries in the world have been taking up with the green building... distribution asymmetry, drip and spray used in agriculture irrigation are introduced into urban. Drip irrigation is good at water-saving because water contacts directly with soil without sprayed in the air, especially using non-traditional water resource...

He, Q.; Gou, H.; Dai, Z.; Hao, Y.

2006-01-01T23:59:59.000Z

316

Both authors are members of the staff of the Northwest  

E-Print Network (OSTI)

they reached the bottom layer Dun ng the next 2 or 3 wee\\... . the alevins distnbuted them ehes until they were with th e pea\\... of emergence of fry from gravel Incuba- tors. Survival from eyed eggs to fry In th e Incubator With the turf substrate was 98 percent The high poro\\lt\\ o f A\\trol urf and the low denSi ty of th

317

, ZHOU Q ing2jun , Chen R ay T.  

E-Print Network (OSTI)

le 2ring m ic roresona tor as a prac tica l optica l filte r. The influence of optica l loss is a lso ana lyzed. Low optica l loss w ill cause sha rp a ttenua tion of the filte ring response and seve re optica l loss a lso can w iden the bandw id th and inc rease the bandw id th ra tio. Key words: integ ra

Chen, Ray

318

Process Energy Audit for Large Industries  

E-Print Network (OSTI)

be the identification of DSM technologies. Once the DSM technologies are identified, the audi tor would verify whether those technologies and equipment are commercially viable and proven in the market. Task 13 - Obtain Vendor Data Respective DSM technology... and equipment vendors would be contacted to obtain technical details on the equipment which is likely to be recommended. Task 14 - Obtain Quotation/Proposal Prices for selected DSM equipment will be obtained from respective vendors. Task 15 - Calculate...

Chari, S.

319

Calorimetric and Resistive Measurements of Amorphous Splat Cooled La1-Xgax Foils  

E-Print Network (OSTI)

- tors have been directed toward the simple (nontransi- tion) metals. A survey of the available experimental data on the simple' amorphous metals leads one to the following conclusions: (i) they are strong-coupling superconductors with electron...?~Au?alloys to be only intermediate coupling superconductors, and tun- neling measurements by Tsuei et al. ' indicated weak- coupling superconductivity in several a-TM alloys. These results are very interesting in light of the very general argument by Bergmann...

SHULL, WH; Naugle, Donald G.; POON, SJ; JOHNSON, WL.

1978-01-01T23:59:59.000Z

320

Low-Frequency Electromagnetic Response Function for Strong-Coupling Superconductors  

E-Print Network (OSTI)

properties of superconduc- tors is well known. For example, the frequency dependence of the electrical conductivity in strong- coupling superconductors has been observed by both infrared" and microwave' techniques. Also, the magnitude and temperature... dependence of the low-frequency conductivity for Pb have been in- ferred from measurements of magnetic field at- tenuation, ' while kinetic inductance' measure- ments have been used to study this temperature dependence for amorphous superconductors...

SCHOLTEN, PD; LEJEUNE, JD; SASLOW, WM; Naugle, Donald G.

1977-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "admi nistra tor" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Indigenous Nations Journal, Volume 2, Number 2 (Fall, 2001): Book Reviews  

E-Print Network (OSTI)

Book Reviews The Challenge of Diversity: Indigenous Peoples and Reform of the State in Latin America, Willem Assies, Gemma van der Haar, and Andre Hoekema, edi tors. (Amsterdam: Thela Thesis, 2000. 315p.; p., 24 cm. ISBN 9055380458...). In The Challenge of Diversity: Indigenous Peoples and Reform of the State in Latin America, Assies, van der Haar and Hoekema present a series of articles tracing and explaining the role of Indigenous peoples in promoting and shap ing the recent wave...

2001-09-01T23:59:59.000Z

322

Experimental study of the effect of sodium carbonate on the conversion of cellulose to oil  

E-Print Network (OSTI)

29 2. Runs at the same conditions for data reliability 3T LIST OP PIGUBES Piquze Paqe Schematid diagram of the Reactor. . . . . . . . . . . . . . . . 18 2 Tempe rature hehavioz of the reactor . . . . . . . . . . 23 3 Effect of Catalyst Loadinq... for leak testinq the reactor. Unsuccessful runs in the early stages vere caused hy the breakinq of the rupture disc and leakinq in the aqita tor sealinq system. The data from these runs vere d iscarded. A total of 35 runs were selected for analysis a...

Chu, Siu-Hung

2012-06-07T23:59:59.000Z

323

A revision of the electric ray genus Diplobatis with notes on the interrelationships of Narcinidae (Chondrichtyes, Torpediniformes)  

E-Print Network (OSTI)

A REVISION OF THE ELECTRIC RAY GENUS DIPLOBATIS WITH NOTES ON THE INTERRELATIONSHIPS OF NARCINIDA . (CHONDRICHTHYES, TOR?EDINIFORNES) A Thesis by JANICE DRUKTEN FECHHELH Submitted to t. he Craduate College of Texas A&M University in partial... fulfillment of tne requirement for the degree of WASTER OF SCIENCE December 19BI Hajor Subject: Wilolife and Fisheries Sciences A REVISION OF THE ELECTRIC RAY GENUS DIPLOBATIS WITH NOTES ON THE INTEPRELATIONSHIPS OF' NARCINIDAE (CHONDRICHTHYES...

Fechhelm, Janice Drukten

2012-06-07T23:59:59.000Z

324

LCPHSM2002006 IIScCTS02/02  

E-Print Network (OSTI)

# or Z, from the electric dipole form factor (EDM) d # # (q 2 ), or its generalization for the Z couplingV with the possibility of an extension to 800 GeV [4]. It is a multi­purpose machine that will test various aspects of certain vec­ tor correlations, which are non­vanishing in the event that the # lepton has an EDM or a WDM

325

Atmos. Chem. Phys., 11, 67876808, 2011 www.atmos-chem-phys.net/11/6787/2011/  

E-Print Network (OSTI)

-6787-2011 © Author(s) 2011. CC Attribution 3.0 License. Atmospheric Chemistry and Physics Trace gas and particle emissions from open biomass burning in Mexico R. J. Yokelson1, I. R. Burling1, S. P. Urbanski2, E. L. Atlas3 measurements of emission fac- tors (EF) for trace gases and PM2.5 made in southern Mexico in March of 2006 on 6

Meskhidze, Nicholas

326

A Review of "Christopher Plantin and Engraved Book Illustrations in Sixteenth-Century Europe" by Karen Bowen and Dirk Imhof  

E-Print Network (OSTI)

and audience for such works with intaglio illustrations. The first two chapters set the stage for the in-house analysis. First the authors trace an earlier history of intaglio illustrations for books, rare but not unprecedented (they omit the Lucas Cranach... considerations helped shape artistic production. Indeed, the final chapter discusses Plantin prints of texts for other illustra- tors? editions, especially print publisher Philips Galle or his friend, atlas-maker Abraham Ortelius; those associates remained...

Silver, Larry

2010-01-01T23:59:59.000Z

327

Topologies and approximation operators induced by binary relations  

E-Print Network (OSTI)

Rough set theory is an important mathematical tool for dealing with uncertain or vague information. This paper studies some new topologies induced by a binary relation on universe with respect to neighborhood opera- tors. Moreover, the relations among them are studied. In additionally, lower and upper approximations of rough sets using the binary relation with respect to neighborhood operators are studied and examples are given.

Nurettin Bagirmaz; A. Fatih Ozcan Hatice Tasbozan; Ilhan Icen

2014-05-09T23:59:59.000Z

328

Preliminary version September 29, 2011  

E-Print Network (OSTI)

) and is isomorphic to the symmetric group S3. We show that the extension does not split over Z[ 1 23 ], but does On the modular curve X0(23) Ren´e Schoof Dipartimento di Matematica 2a Universit`a di Roma "Tor Vergata" I-00133 Roma ITALY Email: schoof@mat.uniroma2.it Abstract. The Jacobian J0(23) of the modular curve X0(23

Schoof, René

329

Numerical and Experimental Analysis of Combustion and Exhaust Emissions in a Dual-Fuel Diesel/Natural Gas Engine  

Science Journals Connector (OSTI)

Department of Mechanical Engineering, UTV, University of Rome Tor Vergata, Rome, Italy, and IM-CNR, Istituto Motori of Italian National Research Council, Naples, Italy ... Accordingly, the use of NG as primary fuel allows the same compression ratio of the conventional diesel engine; thus, existing diesel engines can be easily converted to dual-fuel operation. ... Thus, a more general combustion model (G-equation or EDC) could be considered to represent flame propagation. ...

Stefano Cordiner; Michele Gambino; Sabato Iannaccone; Vittorio Rocco; Riccardo Scarcelli

2008-02-21T23:59:59.000Z

330

Estimators for models with constraints involving unknown parameters  

E-Print Network (OSTI)

- tor of real numbers. Such estimators have asymptotic variance P(f - c a)2 . If Paa is invertible, then by the Cauchy­Schwarz inequality the asymptotic variance is minimized for cf = (Paa )-1 Paf. The constant cf ^cf = ( ^Paa )-1 ^Paf = n i=1 a(Xi)a(Xi) -1 n i=1 a(Xi)f(Xi). The resulting estimator ^P(f -^cf a) has

Wefelmeyer, Wolfgang

331

Supplement 18, Part 2, Parasite-Subject Catalogue: Parasites: Protozoa  

E-Print Network (OSTI)

.; transmitted by Boophilus and Kusov, V. N., 1958 a calcaratus; Hyalomma asia- Russia: Kazakhstan and ticum; Rhipicephalus tur- Central Asian Republics anieus +cattle Anaplasma marginale, Vec- Grobov, 0. F., I963 a tors transmitted by Rhipicephalus bursa....; and rus lahorensis; Haemaphy- Rusov, V. ?., 1958 a salis sulcata; Dermacentor Russia: Kazakhstan and marginatus +sheep +goats Anaplasma ovis +mouton Anaplasma ovis anemia, sheep Anaplasma ovis bovine Anaplasma ovis complement fixation Central...

Crawley, Lila R.; Segal, Dorothy B.; Humphrey, Judith M.; Rayburn, Jane D.

1972-01-01T23:59:59.000Z

332

Atomic Substitutions in Yba2cu3o7 - Modification of the Electronic-Structure  

E-Print Network (OSTI)

, the atomic valences, and the Fermi en- ergy was calculated. I. INTRODUCTION Since the discovery of the new high-T, superconduc- tors, '2 there have been many studies of changes in the su- perconducting properties of these materials induced by re...307 to determine the modification of the local densities of states, the atomic valences, and the Fermi en- ergy. Some of these results have been presented in an ea.-- lier form. II. METHOD We previously calculated the electronic structure...

RICHERT, BA; Allen, Roland E.

1988-01-01T23:59:59.000Z

333

Compensation of the AKT signaling by ERK signaling in transgenic mice hearts overexpressing TRIM72  

SciTech Connect

The AKT and ERK signaling pathways are known to be involved in cell hypertrophy, proliferation, survival and differentiation. Although there is evidence for crosstalk between these two signaling pathways in cellulo, there is less evidence for cross talk in vivo. Here, we show that crosstalk between AKT and ERK signaling in the hearts of TRIM72-overexpressing transgenic mice (TRIM72-Tg) with alpha-MHC promoter regulates and maintains their heart size. TRIM72, a heart- and skeletal muscle-specific protein, downregulates AKT-mTOR signaling via IRS-1 degradation and reduces the size of rat cardiomyocytes and the size of postnatal TRIM72-Tg hearts. TRIM72 expression was upregulated by hypertrophic inducers in cardiomyocytes, while IRS-1 was downregulated by IGF-1. TRIM72 specifically regulated IGF-1-dependent AKT-mTOR signaling, resulting in a reduction of the size of cardiomyocytes. Postnatal TRIM72-Tg hearts were smaller than control-treated hearts with inhibition of AKT-mTOR signaling. However, adult TRIM72-Tg hearts were larger than of control despite the suppression of AKT-mTOR signaling. Activation of ERK, PKC-?, and JNK were observed to be elevated in adult TRIM72-Tg, and these signals were mediated by ET-1 via the ET receptors A and B. Altogether, these results suggest that AKT signaling regulates cardiac hypertrophy in physiological conditions, and ERK signaling compensates for the absence of AKT signaling during TRIM72 overexpression, leading to pathological hypertrophy. -- Highlights: • TRIM72 inhibits AKT signaling through ubiquitination of IRS-1 in cardiac cells. • TRIM72 regulates the size of cardiac cells. • TRIM72 regulates size of postnatal TRIM72-overexpressing transgenic mice hearts. • Adult TRIM72-overexpressing transgenic mice hearts showed cardiac dysfunction. • Adult TRIM72 transgenic mice hearts showed higher expression of endothelin receptors.

Ham, Young-Mi, E-mail: youngmi_ham@hms.harvard.edu [College of Life Science and Biotechnology, Korea University, Seoul (Korea, Republic of); Department of Cell Biology, Harvard Medical School, Boston, MA 02115 (United States); Mahoney, Sarah Jane [Department of Cell Biology, Harvard Medical School, Boston, MA 02115 (United States)

2013-06-10T23:59:59.000Z

334

Fermilab Steering Group Report  

NLE Websites -- All DOE Office Websites (Extended Search)

Steering Group Steering Group Eugene Beier University of Pennsylvania Joel Butler Fermi National Accelerator Laboratory Sally Dawson Brookhaven National Laboratory Helen Edwards Fermi National Accelerator Laboratory Thomas Himel Stanford Linear Accelerator Center Stephen Holmes Fermi National Accelerator Laboratory Young-Kee Kim, Chair Fermi National Accelerator Laboratory/ University of Chicago Andrew Lankford University of California, Irvine David McGinnis Fermi National Accelerator Laboratory Sergei Nagaitsev Fermi National Accelerator Laboratory Tor Raubenheimer Stanford Linear Accelerator Center Vladimir Shiltsev Fermi National Accelerator Laboratory Maury Tigner Cornell University Hendrik Weerts Argonne National Laboratory Contributors Neutrino Physics Group Eugene Beier University of Pennsylvania

335

TITLE  

Office of Legacy Management (LM)

Floodplains and Wetlands Floodplains and Wetlands Survey Results for the Rulison and Rio Blanco Sites, Colorado December 1 993 Environmental Restoration Floodplains and Wetlands Survey Results tor the Rulison and Rio Blanco Sites, Colorado Prepared For: U.S. Department of Energy Environmental Restoration Division DOE Nevada Operations Office Las Vegas, Nevada 89 193-85 18 Prepared By: l T CORPORATION 4330 S. Valley View Blvd., Suite 114 Las Vegas, Nevada 89 103 Work Performed under Contract No: DE-AC08-92NV 10972 December 1993 Table of Contents . . List of Figures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 List of Tables . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . iii List of Acronyms and Abbreviations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . iv

336

Nanobeams.PDF  

NLE Websites -- All DOE Office Websites (Extended Search)

2 2 CBP Tech Note-276 February 2003 Comparison of Alignment Tolerances in the Linear Collider Damping Rings with Those in Operating Rings Tor Raubenheimer 1 and Andrzej Wolski 2 1 Stanford Linear Accelerator Center Stanford University Menlo Park, CA 94025 2 Lawrence Berkeley National Laboratory University of California Berkeley, CA 94720 Abstracs The next generation linear colliders require damping rings to generate beam with very small transverse emittances to attain the desired luminosity. The required emittances are smaller than that of most operating synchrotron radiation sources. In this paper, the alignment tolerances needed to attain these small emittances are compared with those of the operating synchrotron

337

An investigation of the torsional stiffness of certain thin-walled triangular sections  

E-Print Network (OSTI)

of spanwise members does not 1ncrease the tors1onsl stiffness, but does increase the ultimate strength of the section. TABLE I DIMENSIONS OF SPECIMENS USED IN TORSION TESTS Skin Rib Rib No. Speoimsn Thiokneas No. Spacing Po sitions Panel t in Ri in Sti f... 3510 10620 4040 11020 54 50 7380 1500 3765 2760 2250 7050 8330 5050 8640 6820 10800 5790 1332 4600 1782 2185 5810 2380 8120 4 1250 4 784 4 2 625 2 2 392 2 1 312 1 1 196 1 1 392 2 1 98 0. 5 (1) Buckling torques taken from...

Roberts, Raymond Harold

2012-06-07T23:59:59.000Z

338

SIRT1 inactivation induces inflammation through the dysregulation of autophagy in human THP-1 cells  

SciTech Connect

Highlights: Black-Right-Pointing-Pointer SIRT1 inactivation decreases autophagy in THP-1 cell. Black-Right-Pointing-Pointer Inhibition of autophagy induces inflammation. Black-Right-Pointing-Pointer SIRT1 inactivation induces inflammation through NF-{kappa}B activation. Black-Right-Pointing-Pointer The p62/Sqstm1 accumulation by impairment of autophagy is related to NF-{kappa}B activation. Black-Right-Pointing-Pointer SIRT1 inactivation is involved in the activation of mTOR and decreased AMPK activation. -- Abstract: Inflammation plays a crucial role in atherosclerosis. Monocytes/macrophages are some of the cells involved in the inflammatory process in atherogenesis. Autophagy exerts a protective effect against cellular stresses like inflammation, and it is regulated by nutrient-sensing pathways. The nutrient-sensing pathway includes SIRT1, a NAD{sup +}-dependent histone deacetylase, which is implicated in the regulation of a variety of cellular processes including inflammation and autophagy. The mechanism through which the dysfunction of SIRT1 contributes to the regulation of inflammation in relation to autophagy in monocytes/macrophages is unclear. In the present study, we demonstrate that treatment with 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide (Sirtinol), a chemical inhibitor of SIRT1, induces the overexpression of inflammation-related genes such as tumor necrosis factor (TNF)-{alpha} and interleukin (IL)-6 through nuclear factor (NF)-{kappa}B signaling activation, which is associated with autophagy dysfunction, as shown through p62/Sqstm1 accumulation and decreased expression of light chain (LC) 3 II in THP-1 cells. The autophagy inhibitor, 3-methyladenine, also induces inflammation-related NF-{kappa}B activation. In p62/Sqstm1 knockdown cells, Sirtinol-induced inflammation through NF-{kappa}B activation is blocked. In addition, inhibition of SIRT1 is involved in the activation of the mammalian target of rapamycin (mTOR) pathway and is implicated in decreased 5 Prime -AMP activated kinase (AMPK) activation, leading to the impairment of autophagy. The mTOR inhibitor, rapamycin, abolishes Sirtinol-induced inflammation and NF-{kappa}B activation associated with p62/Sqstm1 accumulation. In summary, SIRT1 inactivation induces inflammation through NF-{kappa}B activation and dysregulates autophagy via nutrient-sensing pathways such as the mTOR and AMPK pathways, in THP-1 cells.

Takeda-Watanabe, Ai; Kitada, Munehiro; Kanasaki, Keizo [Diabetology and Endocrinology, Kanazawa Medical University, Kahoku-Gun, Ishikawa (Japan)] [Diabetology and Endocrinology, Kanazawa Medical University, Kahoku-Gun, Ishikawa (Japan); Koya, Daisuke, E-mail: koya0516@kanazawa-med.ac.jp [Diabetology and Endocrinology, Kanazawa Medical University, Kahoku-Gun, Ishikawa (Japan)] [Diabetology and Endocrinology, Kanazawa Medical University, Kahoku-Gun, Ishikawa (Japan)

2012-10-12T23:59:59.000Z

339

Gender Comparisons of Mechanomyographic Amplitude and Mean Power Frequency Versus Isometric Torque Relationships  

E-Print Network (OSTI)

of the biceps brachii. Journal of Electromyography and Kinesiology, 14, 555-564. Bichler, E. (2000). Mechanomyograms recorded during evoked contractions of single mo- tor units in the rat medial gastrocnemius muscle. European Journal of Applied Physi- ology, 83...-599. Pedhazur, E.J. (1997). Multiple regression in behavioral research: Explanation and predic- tion (3rd ed.). Fort Worth: Harcourt Brace College Publ. Perry, S.R., Housh, T.J., Johnson, G.O., Ebersole, K.T., Bull, A.J., Evetovich, T.K., & Smith, D.B. (2001a...

Beck, Travis W.; Housh, Terry J.; Johnson, Glen O.; Weir, Joseph P.; Cramer, Joel T.; Coburn, Jared W.; Malek, Moh H.

2005-01-01T23:59:59.000Z

340

Determination of the star tracker-inertial measurement unit misalignment  

E-Print Network (OSTI)

these systems could be oval- ated. To meet this requirement, a Celestial Simul tor Complot was built by:;e' rfott, a division of "ener"l precision, Inc. , and installed at hollomun Air Force Base, F, ew '. i" 6 x i c 0 e Only a limited test pro, ', ;ram hao.... !!ociwoll, chief of tne i'. ni lysio division of toe i:sntral Inertial Guidance Test;:acilityy iaollossn I~ir;"'ores iicsc f ZION . ", cxico, for evaluating accelcromstcrs on a gr cision cen'tri f Qi. ;o ~ "hs suti;ox is also grutogul for the valunblo...

Shearer, Milo Edward

2012-06-07T23:59:59.000Z

Note: This page contains sample records for the topic "admi nistra tor" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

The extraction of a mono-energetic neutron beam of maximum intensity from a nuclear reactor  

E-Print Network (OSTI)

all aluminum was taken because Mn has a high capture cross section for thermal neutrons and becomes highly radioactive Mn . Mn has a long half life and gives off 56 FIa 6 SHIELDING PLUG WITH CO I. LIMA TOR TUSE RVNNERS END VIEW POSITION I NS... the horizontal plane. Rather than try to construct a cylindrical boral liner for the tube, it was decided that a rectangular one would be much simpler to construct and would suit the purpose just as well. The rectangular liner was constructed to fit just...

Snow, Edward Clark

1965-01-01T23:59:59.000Z

342

Effect of dynamic bending of level ice on ship's continuous-mode icebreaking  

Science Journals Connector (OSTI)

Abstract This paper focuses on the influences of the dynamic effects of ship–ice–water interaction on ship performance, ship motions, and ice resistance. The effects of the dynamic bending of ice wedges and ship speeds are especially investigated. The study is carried out using a numerical procedure simulating ship operations in level ice with ship motions in six degrees of freedom (DOFs). A case study is conducted with the Swedish icebreaker Tor Viking II. The 3-D hull geometry of the ship is modeled based on the lines drawing. The predicted performance of the ship is compared with data from full-scale ice trials.

Xiang Tan; Kaj Riska; Torgeir Moan

2014-01-01T23:59:59.000Z

343

SPRINT: a tool for probabilistic source term prediction for use with decision support systems  

Science Journals Connector (OSTI)

......These values are stored in CPTs (excel file) M odify A nn o tat e R e c o r d Network/ M o d e l R e p o s i tor y Fi l e (E xcel file) Pr e c a lc u l at e d So ur ce T e r ms C a s e F i l e P l a n t S tatu s Pr e d ic t i o n X M L Ou t p u t Fi l e......

E. Grindon; C. G. Kinniburgh

2004-06-01T23:59:59.000Z

344

Binding of soluble immune complexes to adult Schistosoma mansoni: evidence for IgG-Fc and complement receptors  

E-Print Network (OSTI)

the complexes were incubated with parasites at 4 C and retention of bound complexes was dependent on the presence 0 of a metabolic inhib1tor, 2-deoxy-0-glucose in the incubat1on mixture. AgAb binding required the presence of an intact Fc on the Ig... fraction (top wel I ) and the intact IgG (lower well) of rabbit anti-BSA serum . . 17 Fi g. 3. Immunoelectrophorests of anti-mouse complement C3 (trough) versus normal mouse serum &top weil) and normal mouse serum-minus complement C3 &lower well...

Tarleton, Ricky Lee

2012-06-07T23:59:59.000Z

345

Technical review and summary of soil stabilization methods  

E-Print Network (OSTI)

method ~ (16) e IXised numbers refer to rofcrunces listed in Seotion X, MhLLog rcphy s Two theories, one by proctor and the other by Hogentoglex hove been advanced and used to explain what action oocuro when so%3. (4) is oonpacted ~ i...~tor , in exylcining the theory of soil conpaction~ (1&) states that conpaction is the act oi fox'cing thc fine grains of soil irto the voids between the largex grains, Xn thin process water is introduced into che coil to lubricate the soil particles, and thus help...

Flatt, Douglas Evans

2012-06-07T23:59:59.000Z

346

Structural analysis of inhibition of E. coli methionine aminopeptidase: implication of loop adaptability in selective inhibition of bacterial enzymes  

E-Print Network (OSTI)

binding pocket and has direct contact with the bound inhibitors. Positional uncertainty of these atoms in the structures is reflected in their B-fac- tors. The B-factor values of atoms in this loop refined to high values in some of the structures (2EVM, 2... performed pair-wise comparisons using Cruickshank's diffraction precision index [34] with the addition of linear B-factor scaling as implemented in the program ESCET [35,36]. The C? carbons of residues Table 1: X-ray data collection and refinement statistics...

Ma, Ze-Qiang; Xie, Sheng-Xue; Huang, Qing-Qing; Nan, Fa-Jun; Hurley, Thomas D.; Ye, Qi-Zhuang

2007-12-19T23:59:59.000Z

347

Determination of the effects of audio dosimeter microphone placement on the dosimeter accuracy for exposure to discrete octave bands  

E-Print Network (OSTI)

to D1screte Octave Bands. ( December 1982) Steven Joseph Pasiuk, B. A. , Cornell University Chairman of Advisory Comm1ttee: Dr. Ralph J. Vernon Noise dosimeters play an integral role in noise compliance moni- tor1ng by industry and by the Occupat1... applicable standards recommend that the dosimeter micro- phone be positioned on the collar facing upward. They do not cons1- der that the collar location may not be the best position under all sets of cond1tions and that different predominant noise...

Pasiuk, Steven Joseph

2012-06-07T23:59:59.000Z

348

Close-spaced Knudsen`s mode thermionic converter  

SciTech Connect

It is demonstrated that the Knudsen`s mode of the thermionic converter (TIC) operation can be realized in a TIC with the interelectrode spacing 15{divided_by}30 {mu} and the emitter work function 5{divided_by}5.5 eV at the emitter temperature above 1800 K and cesium vapor pressure 0.5{divided_by}1 tor. With the use of reflective coating applied to the collector, efficiency of such TIC can achieve the level in excess of 30%.

Kucherov, R.Ya.; Nikolaev, Y.V. [Research Inst. of SIA Lutch, Podolsk (Russian Federation)

1995-12-31T23:59:59.000Z

349

Texas Rice, Volume III, Number 1  

E-Print Network (OSTI)

is rich in silica, so is a potential source of silicon for a variety of industrial uses. (Science News, March 2000) Also working on silica extraction is Andrew Proc- tor, a food chemist for the Arkansas Agricultural Ex- periment Station. He obtained USDA..., such as found in sand,” Proctor said. “That makes it easy to turn it into the raw material for many useful products.” This use for rice hull silica is attracting industry interest. “They’re very interested because wide-scale use would reduce the environmental...

350

A study of the condensation of propene and isobutene with benzene in the presence of anhydrous ferric chloride  

E-Print Network (OSTI)

A STUDT Qt THE OCNZESlSATIQS OP PHQP%SE ASO ZSOSOTESE SZTH EEWZCEE IH THE ~QE Qp ASHTCEOUS WEEHZQ OHX QEISE Lewis Lialea Qarpeater Jwas 1ESS Approval as to style aa4 contest rsec~alehi H Q o t 0 p rtasat o Ohealstrr ma Qh~ A STUDI Of THE O... of the 44rlsaltaral an4 Hsshaaf sal Oolloso ef Texas Partial Falfilmoat of ihs Reqairsasats for the BeSres of Raster of Solsaae Ha Jor Sab)eot s Ohematsal Eagaoerlsg By Loafs Lla4sa OarPsa'tor yea? LOSS ) zzP 7 gest-& The writer ?%shee ae express...

Carpenter, Louis Linden

1938-01-01T23:59:59.000Z

351

Using Renewable Energy to Pump Water (Spanish)  

E-Print Network (OSTI)

que est? dentro del pozo Usted puede ahorrar dinero y ayudar a reducir la contaminaci?n ambiental mediante el uso de fuentes de energ?a renovable ? tal como energ?a solar o energ?a e?lica ? en su hogar, para el riego por goteo o para pozos de agua para... que se coloca en el agua cerca del fondo del pozo y es movido por la barra o flecha El propulsor debe tener muchas h?lices para desarrollar una potente tor- si?n inicial, la cual es necesaria para que la bomba de pistones empiece a operar. Generalmente...

Mecke, Michael; Enciso, Juan

2007-06-08T23:59:59.000Z

352

Effect of Cotton Seed and Cotton Seed Meal in Feeding Hogs  

E-Print Network (OSTI)

............................. A. J ROSE: PresiLLGLLu.. .u,lado. HOLLINGI AVITT. .. OF DIREC A,-.=+ TORS A. P n. Agr.. ........ LDS.. ... EIANCE . . tnor. ~bia. ~llege Sta ST A A...... FF. ...... .l vv. UUBL aist. rian. .a IGTON, l\\i. SC. ... 1. V. nr...- - . I 257 -71, nn- Ii$igliL oj Feb 23, Iti'J". 145 81 45 99 Pc 165 Poi - 1st. Period-10 days.. . 2nd. Period-13 days .... 3rd. Period-10 days. .... Totals 33 days ..... < .......... Cost.. .. Mar. 9,1892. --- 130 87 .- S 3 - 1 3...

Curtis, Geo. W; Carson, J. W.

1892-01-01T23:59:59.000Z

353

V  

NLE Websites -- All DOE Office Websites (Extended Search)

. 1.1 I . COO-30.72-25 11 t 1 Hadronic Form Factors in Asymptotically Free Field Theories David J. Gross and S.B. Treiman Joseph Henry Labor atorie s of Physics -NOTICE- Pri nce ton Uni ver sit y 1 1 This repor t was prep ared as an acco unt of work 1 Pri nce ton , New Jer sey 1 spons ored by the Unite d State s Gove rnme nt. Neith er 1 1 the Un ited Sta tes nor the Un ited Sta tes Ato mic Ene rgy I 08 54 0 1 j Comm issi on, nor any of thei r empl oyee s, nor any of I the ir con trac tors , sub con trac tors , or the ir em plo yee s, 111 »tti' R'111 wou ld not infr inge priv ate ly own ed righ ts. 1 - .3 ABSTRACT The breakdown of Bjorken scaling in asymptotically free gauge theories of the strong interactions is explored for its implications on the large q2 behavior of nucleon form factors.

354

Accurate evolutions of unequal-mass neutron-star binaries: properties of the torus and short GRB engines  

E-Print Network (OSTI)

We present new results from accurate and fully general-relativistic simulations of the coalescence of unmagnetized binary neutron stars with various mass ratios. The evolution of the stars is followed through the inspiral phase, the merger and prompt collapse to a black hole, up until the appearance of a thick accretion disk, which is studied as it enters and remains in a regime of quasi-steady accretion. Although a simple ideal-fluid equation of state with \\Gamma=2 is used, this work presents a systematic study within a fully general relativistic framework of the properties of the resulting black-hole--torus system produced by the merger of unequal-mass binaries. More specifically, we show that: (1) The mass of the torus increases considerably with the mass asymmetry and equal-mass binaries do not produce significant tori if they have a total baryonic mass M_tot >~ 3.7 M_sun; (2) Tori with masses M_tor ~ 0.2 M_sun are measured for binaries with M_tot ~ 3.4 M_sun and mass ratios q ~ 0.75-0.85; (3) The mass of the torus can be estimated by the simple expression M_tor(q, M_tot) = [c_1 (1-q) + c_2](M_max-M_tot), involving the maximum mass for the binaries and coefficients constrained from the simulations, and suggesting that the tori can have masses as large as M_tor ~ 0.35 M_sun for M_tot ~ 2.8 M_sun and q ~ 0.75-0.85; (4) Using a novel technique to analyze the evolution of the tori we find no evidence for the onset of non-axisymmetric instabilities and that very little, if any, of their mass is unbound; (5) Finally, for all the binaries considered we compute the complete gravitational waveforms and the recoils imparted to the black holes, discussing the prospects of detection of these sources for a number of present and future detectors.

Luciano Rezzolla; Luca Baiotti; Bruno Giacomazzo; David Link; Jose A. Font

2010-05-13T23:59:59.000Z

355

Fisetin regulates obesity by targeting mTORC1 signaling  

Science Journals Connector (OSTI)

Abstract Fisetin, a flavonol present in vegetables and fruits, possesses antioxidative and anti-inflammatory properties. In this study, we have demonstrated that fisetin prevents diet-induced obesity through regulation of the signaling of mammalian target of rapamycin complex 1 (mTORC1), a central mediator of cellular growth, cellular proliferation and lipid biosynthesis. To evaluate whether fisetin regulates mTORC1 signaling, we investigated the phosphorylation and kinase activity of the 70-kDa ribosomal protein S6 kinase 1 (S6K1) and mTORC1 in 3T3-L1 preadipocytes. Fisetin treatment of preadipocytes reduced the phosphorylation of S6K1 and mTORC1 in a time- and concentration-dependent manner. To further our understanding of how fisetin negatively regulates mTORC1 signaling, we analyzed the phosphorylation of S6K1, mTOR and Akt in fisetin-treated TSC2-knockdown cells. The results suggested that fisetin treatment inhibits mTORC1 activity in an Akt-dependent manner. Recent studies have shown that adipocyte differentiation is dependent on mTORC1 activity. Fisetin treatment inhibited adipocyte differentiation, consistent with the negative effect of fisetin on mTOR. The inhibitory effect of fisetin on adipogenesis is dependent of mTOR activity, suggesting that fisetin inhibits adipogenesis and the accumulation of intracellular triglycerides during adipocyte differentiation by targeting mTORC1 signaling. Fisetin supplementation in mice fed a high-fat diet (HFD) significantly attenuated HFD-induced increases in body weight and white adipose tissue. We also observed that fisetin efficiently suppressed the phosphorylation of Akt, S6K1 and mTORC1 in adipose tissue. Collectively, these results suggest that inhibition of mTORC1 signaling by fisetin prevents adipocyte differentiation of 3T3-L1 preadipocytes and obesity in HFD-fed mice. Therefore, fisetin may be a useful phytochemical agent for attenuating diet-induced obesity.

Chang Hwa Jung; Heemun Kim; Jiyun Ahn; Tae-Il Jeon; Dae-Hee Lee; Tae-Youl Ha

2013-01-01T23:59:59.000Z

356

SLAC  

NLE Websites -- All DOE Office Websites (Extended Search)

WG1 - Accelerator Design Schedule WG1 - Accelerator Design Schedule Tuesday Wednesday Thursday Friday 9:00 NanoBPM/FEATHER/FONT Plenary IR RF Structures Joint session N. Delerue: FEATHER A. Seryi: NLC IR1/IR2 Layout/Lattices Z. Li: Structure parameter optimization P. Burrows: FONT F. Pilat: US Cold IR Design Cavity design issues - discussion N. Delerue: Kicker Design for FEATHER H. Yamaoka: Support tube R&D for Final Quad Roger Jones: Wakefield calculations DR/ATF 10:30 J.Frisch: Overview of SLAC R&D on Inertial Stabilization Frequency control tolerances - discussion T. Raubenheimer: Ions at ATF E.Doyle: Next generation sensor Gordon Bowden: Fabrication tolerances/model J. Wu: CSR All: Discussion on X-angle/Crab cavity status Tor Raubeneimer: Alignment sensitivities B. Nash: IBS in ATF

357

STATEMENT OF CONSIDERATIONS REQUEST BY INVENTOR FOR THE W AIYER OF DOMESTIC AND  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

ATMOSPHERIC TEMPERATURE DIFFERENTIAL POWER ATMOSPHERIC TEMPERATURE DIFFERENTIAL POWER GENERA TOR" DEVELOPED UNDER DOE CONTRACT NO . DE- AT(29-1)-789; DOE INVENTION DISCLOSURE NO. S-43,860; DOE WAIVER NO. W(I) 2008-004. The Petitioner, Anthony J. Russo (Inventor), has requested a waiver of the Government ' s domestic and foreign patent rights in a subject invention entitled "Atmospheric Temperature Differential Power Generator." The invention was conceived by the Inventor while an employee of the Sandia Corporation (Sandia). Sandia is the M&O contractor for the Sandia National Laboratories (SNL), a government-owned, contractor- operated (GOCO) facility, subject to DOE contract number DE-AT(29-1)-789 at the time the invention was made. The subject invention relates to the natural temperature differential between high and low

358

Recovery Act Invests in Cleanup, Preservation of Hanford Site Locomotives, Railcars  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

August 8, 2011 August 8, 2011 RICHLAND, Wash. - With the help of the American Recovery and Reinvestment Act, the Hanford Site is preserving the history of its locomo- tives and railcars as workers clean up the legacy of the Cold War. In the recently completed railcar project - a $5.5 million effort funded by the Recovery Act - the Richland Operations Office and its contrac- tors moved two locomotives and two cask cars onto reclaimed track at the B Reactor for permanent public display. Designated a National Historic Landmark in August 2008, the B Reactor is slated to become part of the national park system commemorating the Manhattan Project and is open for public tours. Hanford once had 158 miles of railroad track that crisscrossed the 586-square-mile reservation. For more than 50 years, diesel locomotives

359

br23082-bw version.qxd  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Executive Office has put a high Executive Office has put a high priority on ensuring U.S. buildings are energy efficient and environmentally sus- tainable. The action plan includes improving Federal procurement of energy-efficient technology, such as photovoltaics. This commitment spearheads the President's Million Solar Roofs Initiative, which aims at installing 1 million solar energy systems on residential, commercial, and public sec- tor buildings by 2010. The Federal sector's portion of that goal is 20,000 facilities. FEMP plays a leading role in meeting this commitment by encouraging and facilitating the use of photovoltaics. Photovoltaics (PV) is a well-proven and reliable technology that is used increasingly in Federal facilities to provide power in remote or difficult-to-access locations. It

360

eCopy, Inc.  

NLE Websites -- All DOE Office Websites (Extended Search)

---. ---. The submitted manuscript has been authored by a co ..racior of (he U. S. Government under contract No. W-31-109-ENG·38. Accordingly, the U. S. Government retains a nonexclusive, royalty·free license to publish or reproduce the published form of this contribution, or allow others to do so, tor C~. Government purposes. LS-180 ADV ANCED PHOTON SOURCE PROPOSAL FOR UPGRADING THE RADIATION SAFETY OF X-RAY LABS N. Friedman July 1991 1. PRESENT STATUS There are t\vo adjacent x -ray labs in building 360, each having two entrance doors. Lab A240 has two x-ray machines and lab A248 has one. All machines are equipped with sliding safety windows and micros witches to monitor the state of the windows - open or closed. Two .. modes of operation are possible.

Note: This page contains sample records for the topic "admi nistra tor" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Gills Onions Advanced Energy Recovery System  

NLE Websites -- All DOE Office Websites (Extended Search)

Gills Onions Gills Onions Advanced Energy Recovery System Turning a Waste Liability into a Renewable Resource Waste to Energy Using Fuel Cells Workshop Washington, DC J 13 2011 January 13, 2011 Dave Reardon, , PE National Director - Water Sustainability HDR Engineering, Inc., Folsom, CA t Gills Onions Backg ground ● 3 rd largest onion p producer in the nation ● 100,000 square-foot processing facility in Oxnard, CA ● 800,000 lbs of onions processed every day ● Prepackaged diced, sliced, whole, pureed, and ring product line P i l 6 ● Process is operati ional 6 days a week - - The Problem... ● 250,000 lbs/day waste onion hauled off site - H l Hauled b d by t tract tor and d wagon t to l local fi l field ld s t to incorporate into soil - Disrupted traffic

362

NEPA COMPLIANCE SURVEY  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

283 283 Project Information Project Title: Restoration of61 -36-SX-10 DOE Code: Project Lead: Jeff Jones Project Ove rview We will be restoring this location 61 -36-SX-10. What are the environmental Da te: 2-9-2010 Cont rac tor Code: impacts? We will be removing all oil contaminated soil from location to the landfarm and recording it in the book. We 2. What is the legal location? will then back fill with clean fill dirt from sec.20. We will remove well head and place a dry hole marl

363

http://www.slac.stanford.edu/~quarkpt/slaconly/lcc0121.pdf  

NLE Websites -- All DOE Office Websites (Extended Search)

1 1 August 2003 Sensitivity to Interaction Region Solenoid Horizontal Motion Peter Tenenbaum and Tor Raubenheimer Stanford Linear Accelerator Center Stanford University Stanford, CA Abstract: Horizontal motion of a linear collider's Interaction Region solenoid magnet will cause vertical motion of the beam at the collision point. An expression relating the two effects is derived, and a tolerance on the solenoid's position is estimated. Sensitivity to Interaction Region Solenoid Horizontal Motion P. Tenenbaum, T.O. Raubenheimer LCC-Note-0121 August 13, 2003 Abstract Horizontal motion of a linear collider's Interatction Region solenoid magnet will cause vertical motion of the beam at the collision point. An expression relating the two effects is derived, and a tolerance

364

NICCR - National Institute for Climate Change Research  

NLE Websites -- All DOE Office Websites (Extended Search)

Contact Us Contact Us For research in the Coastal Center: Torbjörn Törnqvist Tulane University (504) 314-2221 tor@tulane.edu For research in the Northeastern Region: Ken Davis Pennsylvania State University (814) 863-8601 davis@met.psu.edu For research in the Southeastern Region: Rob Jackson Duke University (919) 660-7408 jackson@duke.edu For research in the Midwestern Region: Andy Burton Michigan Technological University (906) 487-2396 ajburton@mtu.edu For research in the Western Region: Bruce Hungate Northern Arizona University (928) 523-0925 bruce.hungate@nau.edu For general information and eligibility: Jeff Amthor U.S. Department of Energy (301) 903-2507 jeff.amthor@science.doe.gov For proposal and grant related questions: Sally Evans NICCR National Office POB 6077 Northern Arizona University

365

A History of the Southeastern Power Administration  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Southeastern Power Administration Southeastern Power Administration 1990-2010 SERVING SOUTHEAST the Distribu teD by us Department of energy southeastern Power Administration 2012 A History of the Southeastern Power Administration 1990-2010 SERVING SOUTHEAST the ii Project contribu tors Sponsor us Department of energy, southeastern Power Administration Contracting Agency us Army corps of engineers, Mobile District Author Patricia stallings, brockington and Associates, inc. Design and Editing john cason and Alicia sullivan, brockington and Associates, inc. iii AcknowleDgeMents The author gratefully acknowledges the efforts of many individuals who contributed to make this history possible. Mrs. Melissa chastain sease initiated the project and worked tirelessly to facilitate an excellent research environment and also established an efficient

366

NEPA COMPLIANCE SURVEY  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

4 4 Project lnfonnation Project Title: Glori Oil-Biotechnology EOR Date: 2-4-10 DOE Code: 6730-020-51132 Contrac tor Code: 8067-757 Project Lead: Mark Duletsky Project Overview This is a proposal to place a water line from the water haul tank to 21-1 6-sx-2. The waterline will be buried 1. What are the environmental impacts? following an existing right of way to the road and then tum and be place in the roadway to the 21 16 sx-2 location. 2. What is the legal location? 3. What is the duration of the project? There will be a minor amount of surface disturbance involed in the project during trenching operations for the 4. What major equipment will be used pipeline. The area will be reclaimed after the pipeline is completed. if any (work over rig, drilling rig,

367

BETWEEN RANDALL COUNTY, TEXAS AND 'I'HE UNITED STATES DEPARTMENT OF ENEKGY  

NLE Websites -- All DOE Office Websites (Extended Search)

BETWEEN BETWEEN RANDALL COUNTY, TEXAS AND - 'I'HE UNITED STATES DEPARTMENT OF ENEKGY This Memorandum of Understanding (hereinslfier callcd "MOU") is between Randall County. Texas, (hereinaner callcd "Cnunty") and thc Uni~ed States Department of Energy: (hcrcinafter called "I3ClE'' or b'l'an?ex"). 1. INTRODUCTION A. BACKGKOUN L) Both prties havc a mutual interest and responsibility for fire fighting activities tu protect penplc, propxty. and the cnvimnmcnt. B. fl RPOSE 'Ihe purpose of this Mot' is to recognize the need Tor coopemtion on certain fire lighting responsibilities of mutuaI conccrn and to provide for the mutual assistance of parties in accordance \hi tith thc Standard Opemting Pmedures (SOP) contained in Appendix A of this

368

LEDSGP/about/guidingstructure | Open Energy Information  

Open Energy Info (EERE)

LEDSGP/about/guidingstructure LEDSGP/about/guidingstructure < LEDSGP‎ | about(Redirected from LEDSGP/about/guiding-structure) Jump to: navigation, search LEDSGP Logo.png Advancing climate-resilient low emission development around the world Home About Tools Expert Assistance Events Publications Join Us About How We Work > Regional Platforms > Working Groups LEDS GP Members Steering Committee Guiding Structure Contacts LEDS-Global-Partnership-Strategic-Vision.pdf Our strategic vision (PDF) provides a vision and a two-year strategy for the LEDS Global Partnership. It presents overarching objectives for the partnership over the next two years, and it defines concrete strategies, actions, and performance metrics to meet these objectives. LEDS-Global-Partnership-TOR.pdf The LEDS GP Terms of Reference serves as a guide to the activities of the

369

U.S. Fish and Wildlife Service Moves toward Net-Zero Buildings (Fact Sheet), Federal Energy Management Program (FEMP)  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

refuge showcases wetland areas and forests that are home to a myriad of migra- refuge showcases wetland areas and forests that are home to a myriad of migra- tory birds and other wildlife. The design team's vision became a reality when the new visitor's center opened its doors in 2010. The 5,879-square foot building provides a starting point for visi- tors to to learn about the wildlife on the refuge. The facility also houses hands-on exhibits, office and classroom space, and a nature-themed store. "The design of this visitor center exemplifies the U.S. Fish and Wildlife's commitment to lowering our carbon footprint," said Libby Herland, Project Leader, Eastern Massachusetts National Wildlife Refuge Complex. "We want this center to help promote the importance of environmental stewardship and connect the public with the beauty

370

Putting Science to Work BUILDING NANOTECHNOLOGY DEVELOPMENT  

NLE Websites -- All DOE Office Websites (Extended Search)

BUILDING BUILDING NANOTECHNOLOGY DEVELOPMENT THOM MAsON NAMED ORNL DiRECTOR Accompanying Congressman Wamp (at lectern) during the grant announcement are, from left, Oak Ridge City Councilwoman Lou Dunlap; Tom Ballard, ORNL director of Economic Development and Partnerships; and Gerald Boyd, manager, DOE Oak Ridge Office. THOM MAsON NAMED ORNL DiRECTOR T hom Mason has been named ORNL's new direc- tor, effective July 1. The choice was announced in late May by UT-Battelle Board of Governors Chair Carl Kohrt and Vice Chair John Petersen. Mason's most recent role has been associate labora- tory director for Neutron Sciences. As head of the Spallation Neutron Source project, he led a consortium of six DOE labs in the design and construction of the $1.4 billion neutron accelerator. Completed on time,

371

Consider tweaking horizontal dispersion at the IP in order to achieve monochromatic collisions, and remove energy bias  

NLE Websites -- All DOE Office Websites (Extended Search)

4 4 SLAC-TN-04-003 February 19, 2004 Abstract This note documents a set of expressions used to explore the issue of whether or not it is reasonable to consider a conventional positron source for a Tesla formatted beam. The critical issu Monochromatization Option for NLC Collisions Andrei Seryi, Tor Raubenheimer Stanford Linear Accelerator Center Stanford University 2575 Sand Hill Road Menlo Park, CA Abstract: In this note, we consider an option for NLC operation where the Interaction Point beam parameters are adjusted in order to increase the energy resolution. This is achieved by squeezing the horizontal betatron function at the IP and simultaneously introducing a horizontal dispersion (with a different sign for electron and positron

372

LANL: Physics Flash May 2012  

NLE Websites -- All DOE Office Websites (Extended Search)

May 2012 May 2012 I N S I D E 2 From Steve'S deSk 3 ribbonS cut For majorana demonStra- tor Laboratory one miLe underground 4 PreStridge Featured at brookhaven Women in Science Lecture SerieS 5 Foam denSity charac- terization Station iS oPerationaL and beneFitting SeLection oF niF hedP targetS 6 headS uP! 2012 hedP&F caPabiLity revieW By Diana Del Mauro ADEPS Communications Like a neuron firing up one connection after another, Michelle Espy is an inspired researcher who likes talking to people and knows how to make things happen. Her inspiration might come from a simple conversation with a scientist in another

373

I L  

Office of Legacy Management (LM)

f- f- r a-.--+ _ . . .* i_ : CI r . : . . I . f" b" ? ' ,' ' , I L $.. . 0. .' ?, : _' . *r: :,: : .,: ' , . r:. i ' 3"' 3. L SURVEY F THE DITCHES AT THE ST t lJl@ ,bilRPORT STORAGE SITE, ' , :I (SLAPSS) .;' :: ,, .s . .I 1, :' ,., I,: AUGUST 1983 :' PARED FOR THE U.S.DEPARTME?W OF ENERGY &#$nEEi .Ct+TRACT NOa DE-ACOS-8 tOR20722 */, ? 8. ' By 8EGHi' El. NATIONAL, INC. NUGL&YAR FU& O%RAtlONS. .i -.- I 9.0, Box 360 t" OAK RI-. TN. 37830, jl c the united swee Govlanmant. ~ofEaergy,nor~yoftheir *f=~~rmploY~makrmywarranty, onwpwwiwty for the --w-p- =-md6r =PmwathatiQwe _' ". ./ 1 :' p ' , :; : ,/ .' _: k, ,:1 ?.f!i .A--____- _ RADIOLOGICAL SURVEY OF THE DITCHES AT THE ST. LOUIS AIRPORT STORAGE SITE (SLAPSS) JULY 1983 Prepared for the U.S. Department of Energy

374

Number  

Office of Legacy Management (LM)

' ' , /v-i 2 -i 3 -A, This dow'at consists ~f--~-_,_~~~p.~,::, Number -------of.-&--copies, 1 Series.,-a-,-. ! 1 THE UNIVERSITY OF ROCHESTER 1; r-.' L INTRAMURALCORRESPONDENCE i"ks' 3 2.. September 25, 1947 Memo.tor Dr. A. H, Dovdy . From: Dr. H. E, Stokinger Be: Trip Report - Mayvood Chemical Works A trip vas made Nednesday, August 24th vith Messrs. Robert W ilson and George Sprague to the Mayvood Chemical F!orks, Mayvood, New Jersey one of 2 plants in the U.S.A. engaged in the production of thorium compounds. The purpose of the trip vas to: l 1. Learn the type of chemical processes employed in the thorium industry (thorium nitrate). 2. Survey conditions of eeosure of personnel associated vith these chemical processes. 3. Obtain samples of atmospheric contaminants in the plant, as

375

C:\ANNUAL\VENTCHAP.V8\NewNGA02.vp  

Gasoline and Diesel Fuel Update (EIA)

· The increase in natural gas consumption in the electric power sector over the past few years has resulted from building new gas-fired electric genera- tors across the country. In 2001 alone, more than 40,000 megawatts of efficient, gas-fired electric power generation was placed into service. Gas-fired turbines have become the favored new source of elec- tricity for their capability to start up quickly during peak demand periods. · Total natural gas consumed in the electric power sector is now roughly 26 percent of total deliveries to consumers in the country, compared to approxi- mately 20 percent in 1997. In terms of volumes con- sumed by sector, natural gas consumption for electric power generation is second only to industrial consumption. · End use consumer prices increased in each sector of the natural gas market in 2001 (Figure 5). Prices climbed 24 percent in the residential

376

Ground-Source Heat Pumps Applied to Federal Facilities, Second Edition  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

and exterior to the facility, are typically less and exterior to the facility, are typically less than those for conventional systems. Potential Application The technology has been shown to be techni- cally valid and economically attractive in many applications. It is efficient and effective. This Federal Technology Alert reports on the collec- tive experience of heat pump users and evalua- tors and provides application guidance. An estimated 400,000 ground-source heat pumps are operating in the private and public sector, although most of these systems operate in resi- dential applications. A ground-source heat pump system can be applied in virtually any category of climate or building. The large num- ber of installations testifies to the stability of this technology. The reported problems can usually be attributed to faulty design or

377

The Standards Actions, August 1998  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

standard project was recently can- standard project was recently can- celed. If you have any questions about this action, please contact the persons listed below. • Guidelines for Preparing Criti- cality Safety Evaluations at De- partment of Energy Non-Reac- tor Nuclear Facilities, Project Number SAFT-0069; Jerry McKamy, EH-34, 301-903-8031, Jerry. McKamy@hq.doe.gov. DOE Technical Stan- dards Recently Sent for Coordination The appropriate Technical Stan- dards Managers (TSMs) will pro- vide selected reviewers with cop- ies for comment. The full text of this document is available on the Technical Standards Program (TSP) Web Site at the URL shown at the bottom of this page. If you wish to comment on this document, please notify your TSM. • Tritium Handling and Safe Storage, Project Number SAFT-0054;

378

REQUEST BY HONEYWELL INTERNATIONAL, INC. FOR AN ADVANCE WAIVER OF DOMESTIC AND FOREIGN RIGHTS IN  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

FOR AN FOR AN ADVANCE WAIVER OF DOMESTIC AND FOREIGN RIGHTS IN SUBJECT INVENTIONS MADE IN THE COURSE OF OR UNIER UT- BATTELLE, LLC SUBCONTRACT NO. 4000015922 UNDER PRIME CONTRACT NO. DE-AC05-00R22725; DOE WAIVER DOCKET W(A)- 2003-018 [ORO-779] Honeywell International, Inc. (Honeywell) has made a timely request tor an advance waiver to worldwide rights in Subject Inventions made in the course of or under UT- Battelle, LLC Subcontract No. 4000015922, entitled, "Phased Sensor Feasibility Demonstration" under UT-Battelle Prime Contract No. DE-AC05-00OR22725. the scope of work Involves a bench-top feasibility study of a portfolio of inventions describing a concentration-enhancing micro-gas analyzer, based on cas chromatography principles. The inventions were conceived prior to the execution of the

379

LCC-0030 cover.PDF  

NLE Websites -- All DOE Office Websites (Extended Search)

0 02/12/99 0 02/12/99 The Effect of Intrapulse RF Variation On Bunch Train Energy Spread December 2, 1999 C. Nantista and T.O. Raubenheimer Stanford Linear Accelerator Center Stanford, CA, USA Abstract: A brief analysis is presented of the effect of small variations in amplitude and phase in the accelerating rf pulse in addition to the deliberate pulse shaping on the energy deviation along a bunch train and the effects of pulse-to-pulse fluctuations. 1 The Effect of Intra-Pulse RF Variation on Bunch Train Energy Spread Christopher Nantista and Tor Raubenheimer INTRODUCTION: In this note, we present a brief analysis of the effect of small variations in amplitude and phase in the accelerating rf pulse in addition to the deliberate pulse shaping on the energy deviation along a bunch train and the effects of pulse-to-pulse fluctuations.

380

Browse by Discipline -- E-print Network Subject Pathways: Computer  

Office of Scientific and Technical Information (OSTI)

O P Q R S O P Q R S T U V W X Y Z Nabben, Reinhard (Reinhard Nabben) - Institut für Mathematik, Technische Universität Berlin Naber, Gregory L. (Gregory L. Naber) - Department of Mathematics, Drexel University Nabutovsky, Alexander (Alexander Nabutovsky) - Department of Mathematics, University of Toronto Nachbin, André (André Nachbin) - Instituto Nacional De Matemática Pura E Aplicada (IMPA) Nacinovich, Mauro (Mauro Nacinovich) - Dipartimento di Matematica, Università di Roma Tor Vergata Naddef, Denis (Denis Naddef) - Laboratoire des Sciences pour la Conception, l'Optimisation et la Production de Grenoble & Institut polytechnique de Grenoble Nadim, Farzan (Farzan Nadim) - Federated Department of Biological Sciences, Rutgers University at Newark Naehrig, Natalie (Natalie Naehrig) - Fachgruppe Mathematik,

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381

HOW TO OBTAIN EIA PRODUCTS AND SERVICES  

U.S. Energy Information Administration (EIA) Indexed Site

HOW TO OBTAIN EIA PRODUCTS AND SERVICES HOW TO OBTAIN EIA PRODUCTS AND SERVICES For further information on any or the following services, or for answers to energy information questions, please contact ElA's National Energy Information Outer National Energy Infomtaiion Center (NEIC) (202) 586-8800 Energy Information Administration (202) 586-0727 (fax) l-orrtslal Ituilding, Roam 1F-048 TTY: (202) 586-1ISI Washington. DC 20585 E-mail: infocir@eia.doc.gov Electronic Products and Services ElA's Internet Site Services offer nearly all E1A publications. Users can view and download selected pages or entire reports, search Tor information, download LIA tlaia and analysis applications, and find out about new KIA information products aitd sen-ices, World Wide Web: http://www.eia.doe.KOV Gopher: go ph« r ://go ph er .eia .d oe. gov

382

Identification of the Parasitic Chemical Reactions during AlGaN OMVPE  

NLE Websites -- All DOE Office Websites (Extended Search)

Identification of the Parasitic Chemical Reactions during AlGaN OMVPE Identification of the Parasitic Chemical Reactions during AlGaN OMVPE by J. R. Creighton, M. E. Coltrin, and W. G. Breiland Motivation-GaN and AlGaN alloys are ex- tremely important materials with widespread applications for optoelectronics (e.g. solid state lighting) and high power electronics. Or- ganometallic vapor phase epitaxy (OMVPE) is the primary deposition methodology, but it suf- fers from several growth chemistry anomalies. Growth rate and alloy composition are often a sensitive function of temperature and other reac- tor variables. These factors make the AlGaN OMVPE process difficult to control and in- crease the cost of the material. Conventional wisdom has been that the non-ideal OMVPE behavior is due to parasitic "pre-reactions" be-

383

TEAM HEV ARC HITECTURE ENGIN E FU EL TRANS MISSION EN ERGY STOR  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

TEAM TEAM HEV ARC HITECTURE ENGIN E FU EL TRANS MISSION EN ERGY STOR AGE MO TOR Michigan Technological University Through-the-road Parallel 2.0-L 4 Cylinder Spark Ignition Reformulated Gasoline 4-speed Automatic COBASYS, Nickel Metal Hydride - 288V 50 kW Solectria AC Induction Transaxle Mississippi State University Through-the-road Parallel 1.9-L GM Direct Injection Turbo Diesel Bio Diesel (B20) GM F40 6-speed Manual Johnson Controls, Nickel Metal Hydride - 330V 45 kW Ballard Integrated Power Transaxle The Ohio State University Through-the-road Parallel 1.9-L GM Direct Injection Turbo Diesel Bio Diesel (B20) Aisin-Warner AF40 6-speed Automatic Transaxle Panasonic, Nickel Metal Hydride - 300V 67 kW Ballard AC Induction Transaxle /10.6 kW Kollmorgen Brushless DC Generator Pennsylvania State

384

eCopy, Inc.  

NLE Websites -- All DOE Office Websites (Extended Search)

8 8 A NEVI 1'AONOCHROMATOR FOR HIGH HEAT LOAD SYNCHROTRON X-RAY RADIATION* Abstract Ali Khounsary Advanced Photon Source Argonne National Laboratory Argonne,IL60649 The high heat load associated with the powerful and concentrated x-ray beams generated by insertion devices (IDs) at a number of present and many of the future (planned or under construction) synchrotron radiation facilities poses a formidable engineering challenge for the design of monochromators and other optical devices. Successful utilization of the intense x-ray beams from insertion devices depends critically on the development, design, and availability of optical elements that will provide acceptable performance under high heat load. Present mono chroma tors can handle, at best, heat load levels that are an order of magnitude lower than

385

Microsoft Word - ecloud BDS11.doc  

NLE Websites -- All DOE Office Websites (Extended Search)

6 6 SLAC-TN-03-051 September 2003 Single Bunch Electron Cloud Effects in the NLC Beam Delivery System David Chen, Arthur Chang, M. T. F. Pivi, T. O. Raubenheimer Stanford Linear Accelerator Center Stanford University Stanford, CA Abstract: A positron beam passing through a linear collider beam delivery line is finely focused to desired specifications. Unwanted additional focusing is generated by beam-electron-cloud interactions that can cause beam size increases at the IP when there are high cloud densities. This paper examines the severity of the electron cloud effects and assesses the critical cloud density. Single Bunch Electron Cloud Effects in the NLC Beam Delivery System David Chen, Arthur Chang, Dan Bates, Mauro Pivi, Tor Raubenheimer

386

By Irwin Stambler  

NLE Websites -- All DOE Office Websites (Extended Search)

GAS TURBINE WORLD: January-February 2006 GAS TURBINE WORLD: January-February 2006 Diagnostic health monitoring will reduce new technology O&M risk By Irwin Stambler Intelligent diagnostic systems help avoid excessive outages and costly component replacement by calling for corrective action before problems have time to become failures. M any power generators are con- cerned with the financial risk of unpredictable maintenance costs associated with advanced gas turbines they are purchasing or have placed in service. However, intelligence-based diag- nostic systems are available to moni- tor those machines from startup on through shutdown to make sure that compressor, combustors, turbine and all related systems are operating with- in design limitations and expected performance parameters.

387

br23082-bw version.qxd  

NLE Websites -- All DOE Office Websites (Extended Search)

Executive Office has put a high Executive Office has put a high priority on ensuring U.S. buildings are energy efficient and environmentally sus- tainable. The action plan includes improving Federal procurement of energy-efficient technology, such as photovoltaics. This commitment spearheads the President's Million Solar Roofs Initiative, which aims at installing 1 million solar energy systems on residential, commercial, and public sec- tor buildings by 2010. The Federal sector's portion of that goal is 20,000 facilities. FEMP plays a leading role in meeting this commitment by encouraging and facilitating the use of photovoltaics. Photovoltaics (PV) is a well-proven and reliable technology that is used increasingly in Federal facilities to provide power in remote or difficult-to-access locations. It

388

Howard Gruenspecht Deputy Administrator Duties  

Gasoline and Diesel Fuel Update (EIA)

Howard Gruenspecht Howard Gruenspecht Deputy Administrator Duties Howard Gruenspecht was named Deputy Administrator of the U.S. Energy Information Administration (EIA) in March 2003. As the EIA Deputy Administrator, Howard assists the Administrator in collecting, analyzing, and disseminating independent and impartial energy information to promote sound policy-making, efficient markets, and public understanding of energy and its interaction with the econo- my and the environment. EIA provides a wide range of information and data products covering energy production, stocks, demand, imports, exports, and prices. EIA also prepares analyses and special reports on topics of current interest. Howard works closely with the Administra- tor to provide overall leadership, planning, and policy direction for the

389

NEPA COMPLIANCE SURVEY  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

8 8 Project lnfonnation Project Title: Weir Box for Tensleep discharge Date: 1 1-12.{)9 DOE Code: Project Lead: Dan Smallwood Project Overview 1 What are the environmental impacts? 2 . What is the legal location? 3. What 1 s the duration of the projed? 4 . What major equipment will be used if any (work over rig, drilling rig, etc.)? Contractor Code: The primary functions of the bio-treatment facility consist of oil-water separation, cooling, blending, and biological treatment of produced waters. The original facility was designed to treat an average of 50,000 barrels of produced water per day. RMOTC will install at the Tensleep cooling ponds outflow an open channel flow meter suitable for fixed-site monitoring with sensors to measure levels. The flow meter shall contain conversions tor

390

NREL Technical Reports Guide the Way to 50% Energy Savings in Hospitals, Office Buildings (Fact Sheet), NREL Highlights, Research & Development, NREL (National Renewable Energy Laboratory)  

NLE Websites -- All DOE Office Websites (Extended Search)

existing technologies, designers and operators of large existing technologies, designers and operators of large buildings could slash national energy use across a broad range of climates. Researchers at the National Renewable Energy Laboratory (NREL) have developed two technical reports that provide recommendations to help designers and opera- tors of large office buildings and hospitals achieve at least a 50% energy savings using existing technology. Strategies for 50% Energy Savings in Large Office Buildings found that a 50% energy savings can be realized in both low- and high-rise office buildings in a broad range of U.S. climates. Large Hospital 50% Energy Savings details how energy savings from 50.6% to 61.3% can be attained in large hospitals across all eight U.S. climate zones. To reach these energy efficiency

391

Department of Energy Pt. 824, App. A  

NLE Websites -- All DOE Office Websites (Extended Search)

5 5 Department of Energy Pt. 824, App. A not been paid within sixty calendar days after the assessment has been issued, the DOE shall institute an ac- tion in the appropriate District Court of the United States for an order af- firming the assessment of the civil pen- alty. § 824.15 Collection of civil penalties. If any person fails to pay an assess- ment of a civil penalty after it has be- come a final order or after the appro- priate District Court has entered final judgment for DOE under § 824.14, DOE shall institute an action to recover the amount of such penalty in an appro- priate District Court of the United States. § 824.16 Direction to NNSA contrac- tors. (a) Notwithstanding any other provi- sion of this part, the NNSA Adminis- trator, rather than the Director, signs,

392

STAirEMENT OF CONSIDERATIONS REQUEST BY IC GOMES b oNSUL TING AND INVESTEMENT INC., FOR  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

STAirEMENT OF CONSIDERATIONS STAirEMENT OF CONSIDERATIONS REQUEST BY IC GOMES b oNSUL TING AND INVESTEMENT INC., FOR WAIVER OF DOMESTIC }\ND FOREIGN PATENT RIGHTS IN THE IDENTIFIED INVENTIONS, DOE DOCKFT NO. S-119,346; S-119,479; AND S-126, 113, MADE IN COLLABORATION WIT ~ AN INVENTOR FROM ARGONNE NATIONAL LABORATORY; W(1)2012-003 , CH-1647 ; W(l)2012-004 , CH-1648; W(1)2012-005 , CH-1649. I This waiver request is for/ domestic and foreign rights in three joint identified inventions made by employees of Argonne Nlational Laboratory (ANL or Lab) and IC Gomes Consulting and Investment Inc., (IC Gomes). The identified inventions were made during a collaborative interchange between an ANL inve tor and ltacil Gomes, an inventor and principal of IC Gomes. In order to commercialize the tech ology, IC Gomes hereby requests the instant patent waiver to

393

FEMP--Geothermal Heat Pumps  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

heat pump-like an air conditioner or refrigera- heat pump-like an air conditioner or refrigera- tor-moves heat from one place to another. In the summer, a geothermal heat pump (GHP) operating in a cooling mode lowers indoor temperatures by transferring heat from inside a building to the ground outside or below it. Unlike an air condition- er, though, a heat pump's process can be reversed. In the winter, a GHP extracts heat from the ground and transfers it inside. Also, the GHP can use waste heat from summer air-conditioning to provide virtually free hot-water heating. The energy value of the heat moved is typically more than three times the electricity used in the transfer process. GHPs are efficient and require no backup heat because the earth stays at a relatively moderate temperature throughout the year.

394

BEFORE THE U.S. DEPARTMENT OF ENERGY  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Ju the Matter of: Ju the Matter of: Haicr Amcl'ica Ta·ading, LLC ( fi·eezers) ) ) ) ) ) Case Number: 2011-SE~l428 COMl)ROMISE AGREEMENT The U.S. Department of Energy ("DOE") Office of the General Counsel initiated cASe number 2011 ~SE-1428 against Haier America LLC Haier'' or "Respondent") afier DOE testing revealed that distributed in the United States by Haier as Haicr model , may not meet the applicable enet·gy conservation standard. See 10 C.F.R. § 430.32(a). Haier has provided information that the units were distributed as Haier model HMCM106EA. Respondent and DOE, by their authorized representatives, hereby enter into this Compromise Agreement tor the purpose of settling this speci fie enforcement action. I. DEFINITIONS

395

Linear Collider Collaboration Tech Notes  

NLE Websites -- All DOE Office Websites (Extended Search)

5 08//00 5 08//00 Study of Beam Energy Spectrum Measurement in the NLC Extraction Line August 2000 Yuri Nosochkov and Tor Raubenheimer Stanford Linear Accelerator Center Stanford, CA Abstract: The NLC extraction line optics includes a secondary focal point with a very small _- function and 2 cm dispersion which can be used for measurement of outgoing beam energy spread. In this study, we performed tracking simulations to transport the NLC disrupted beam from the Interaction Point (IP) to the extraction line secondary focus (the IP image), `measure' the transverse beam pro_le at the IP image and reconstruct the beam energy spectrum. The resultant distribution was compared with the original energy spectrum at the IP. Study of Beam Energy Spectrum Measurement

396

ch_5  

NLE Websites -- All DOE Office Websites (Extended Search)

HLW & FD EIS HLW & FD EIS 5-73 DOE/EIS-0287 tion dose to the nonin- volved worker and maximally exposed offsite individual and the collective dose to the population residing within 50 miles of INTEC. The radiation dose values for the var- ious alternatives were then multiplied by the dose-to-risk conversion factors, which are based on the 1993 Limitations of Exposure to Ionizing Radiation (NCRP 1993). DOE has adopted these risk fac- tors of 0.0005 and 0.0004 latent cancer fatality (LCF) for each person-rem of radiation exposure to the general public and worker popu- lation, respectively, for doses less than 20 rem. The factor for the population is slightly higher due to the presence of infants and children who are more sensitive to radiation than the adult worker population. DOE used radiation dose information provided

397

Department of Energy Pt. 824, App. A  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

5 5 Department of Energy Pt. 824, App. A not been paid within sixty calendar days after the assessment has been issued, the DOE shall institute an ac- tion in the appropriate District Court of the United States for an order af- firming the assessment of the civil pen- alty. § 824.15 Collection of civil penalties. If any person fails to pay an assess- ment of a civil penalty after it has be- come a final order or after the appro- priate District Court has entered final judgment for DOE under § 824.14, DOE shall institute an action to recover the amount of such penalty in an appro- priate District Court of the United States. § 824.16 Direction to NNSA contrac- tors. (a) Notwithstanding any other provi- sion of this part, the NNSA Adminis- trator, rather than the Director, signs,

398

by Leila Belkora, Office of Public Affairs  

NLE Websites -- All DOE Office Websites (Extended Search)

An invisible hand draws a white circle against a black background, almost filling the screen of a computer monitor. The circle represents the outer edge of the CDF detector at Fermilab. A spray of green, blue, and red lines blooms rapidly from the cen- ter of the circle, revealing the trajecto- ries of particles stemming from the latest collision of a proton and an antiproton in the Tevatron accelera- tor. One green line arcs toward the upper right of the screen, two more curl around to the lower left. Faster than you can say data visualization, the invisible hand draws a yellow box around the green line on the right, the path of the particle with the high- est calculated momentum. The screen goes black again. The image of another proton-antiproton collision at CDF-an ordinary event, as these

399

American Recovery & Reinvestment Act Newsletter - Issue 25  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

PADUCAH, Ky. - American Recovery and Rein- PADUCAH, Ky. - American Recovery and Rein- vestment Act workers are pioneering the use of mobile cranes to overcome challenges in the cleanup of a contaminated Cold War complex at the Paducah Site. Three certified crane operators hired through Re- covery Act funding are using a newly purchased 65-ton crane and two smaller rented cranes to remove equipment from the C-410/420 Feed Plant. Nearly $18 million in additional Feed Plant cleanup is the result of cost savings from the September 2010 demolition of the C-746-A East End Smelter, which was completed a year ahead of schedule and $12 million under budget. "This is the first time we've hired crane opera- tors and operated mobile cranes inside a facility as part of the decontamination and decommissioning program at Paducah," DOE

400

R  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

INFO >lG!IT H INFO >lG!IT H R - 4 !REQUEST FOR RECORDS DlSPOSlTlON AUTHORITY 81 LEAVE BLANK (NARA) use only) (See Instructions on reverse) JOB NUMBER 0: NATIONAL ARCHIVES and RECORDS ADMINISTRATION (NIR) DATE RECEIVED 1. FROM (Agency or establishment) Department of Energy 2. MAJOR SUBDlVlSiON Assistant Secretary for Fossil Enegy 3. MINOR SUBDlVlSlON 4. NAME OF PERSON WITH WHOM TO CONFER 5. TELEPHONE In accordance with the previous provisions of 44 U.S.C 3303a the dispositlon request, including amendments is approved except tor items that may be markec "disposition not approved" or'hithdrawn" in column i 0 6. AGENCY CERTIFICATION 'J I hereby certify that I am authorized to act for this agency in matters pertaining to the disposition of its records and that the records proposed

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they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

eCopy, Inc.  

NLE Websites -- All DOE Office Websites (Extended Search)

ne submitt€~ manuscript has been authored ne submitt€~ manuscript has been authored by J contract:D( of the U. S. Government under contr,.ct No. W·3 1-1 09- ENG·38. Accordingly, "ftc> U. S. Government retains a nonexclusive, Jioyalty·free license to publish or reproduce the published form of this contribution, tOr allow others to do so, for U. S. Government purposes. Radial and Tangential Winding Coil Probes for Sextupole Magnet Measurements 1. Introduction LS-113 S. H. Kim Rotating coil probes of radial and tangential winding geometries for the measurements of the magnetic center, main field integral and multipole coefficients of sextupole magnets are described. Two sets of coils are sufficient for a probe of radial winding geometry. For a tangential winding probe, however, typically several sets of coils are required to

402

Ground Motion Workshop  

NLE Websites -- All DOE Office Websites (Extended Search)

2nd Advanced ICFA Beam Dynamics Workshop 2nd Advanced ICFA Beam Dynamics Workshop on Ground Motion in Future Accelerators November 6 - 9, 2000 SLAC Coordinators: Andrei Seryi & Tor Raubenheimer Proceedings Updated June 26, 2001 Agenda and Presentations Workshop photos Summaries Useful links Poster Goals Introduction to the problems Structure Registration Registered participants Committees Location, Accommodations and Travel Workshop on Ground Motion in Future Accelerators A workshop was held at SLAC that was devoted to ground motion and its effects on future accelerators. Ground motion and vibration can be a limiting effect in synchrotron light sources, hadron circular colliders, and electron/positron linear colliders. Over the last several years, there has been significant progress in the understanding of the ground motion and its effects, however, there are

403

PLEASE RUSH  

Office of Legacy Management (LM)

l-vto-I l-vto-I w-0 e __._ ____ -_-___---_--_--_.-~ ..~_._.. ..~--.~--~--._.__--._-_---.~ --- ~. pLfQ~~--/+J- )fd / c- jJ ' 4 5 -i --- __- -___-__-I_-- PLEASE RUSH N? 1098 . NATIONAL LEAD CO. OF OHIO - HEALTH & SAFETY DIVISION 1956m Industrbl Hygiene or Medical Dept. 1. H.# 328 bnpk Nos.-Date Collected-2/15by JH Route to CES Locdon JOHN VAN RANGE CO l Type of Sample air dS&Analyzed for F Alpha x: Re~~-CINCINNATI, OHIO - Punching washers out of U v Beta metal slab on punch press. ~~~ Re No ventilation in area. Oil pH pira tor worn. 1816 1433 BZ Same as 1815 - 32 washers stamp-/ .02 3 .06 ed in this period. 1817 1430 GA Pump on next press 10' west' of -02 6.5 .13 operation; another operator I ! punching out stainless steel oni I 1 I ! press 12' north of press; Schea

404

Ground-Source Heat Pumps Applied to Federal Facilities, Second Edition  

NLE Websites -- All DOE Office Websites (Extended Search)

E E N E R G Y M A N A G E M E N T P R O G R A M and exterior to the facility, are typically less than those for conventional systems. Potential Application The technology has been shown to be techni- cally valid and economically attractive in many applications. It is efficient and effective. This Federal Technology Alert reports on the collec- tive experience of heat pump users and evalua- tors and provides application guidance. An estimated 400,000 ground-source heat pumps are operating in the private and public sector, although most of these systems operate in resi- dential applications. A ground-source heat pump system can be applied in virtually any category of climate or building. The large num- ber of installations testifies to the stability of this technology. The reported problems can

405

Thought in the Poetry of Keats  

E-Print Network (OSTI)

for Digital Scholarship. http://kuscholarworks.ku.edu Submitted to the Department of English of the University of Kansas in partial fulfillment of the requirements for the Degree of Master of Arts Msster Thesis ¥eKni*ht, Tor 1904 * Thought i n the poetry... of Rests,•• THOUGHT IN THE POETRY OF KEATS BY I d a McKnight T h e s i s f o r t h e Degree o f fyaster o f A r t s . ..-•-in The U n i v e r s i t y o f Kansas. 1904. INTRODUCTION. G e n e r a l c h a r a c t e r o f K e a t s ' p o e t r y...

McKnight, Ida E.

1904-01-01T23:59:59.000Z

406

A theoretical analysis of proportional counter response versus LET  

E-Print Network (OSTI)

'lowing this inspection, the beta spectrum for each of the five isotopes was generaL. d and the Ites'I) ts a~e shown in FTGS. 7, 8, 9, 10 and 11. The reduced EET equation wa. . compuLcd for an eI argy range of 0. 01 Ifcy to 1, 2 I'!eV 44hi! h inc1udcs the eneri y...V) FIG. 15. NcighLcd mass-absorption energy losses for iodine-131 negaL~ns in air . 28 1 0 0 ~ 8 0. 6 03 'a 0 ' 4 'o Ql P s' 0 ~ 2 0 ' 04 0 ~ 12 0 ~ 20 Energy (I'1eV) 0 ~ 36 11G. 16. '~~'sigh Led rsess ? absorption ener gy losses tor Xenon...

Martin, George Gerald

2012-06-07T23:59:59.000Z

407

Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors  

SciTech Connect

Phosphoinositide-dependent protein kinase-1(PDK1) is a master regulator of the AGC family of kinases and an integral component of the PI3K/AKT/mTOR pathway. As this pathway is among the most commonly deregulated across all cancers, a selective inhibitor of PDK1 might have utility as an anticancer agent. Herein we describe our lead optimization of compound 1 toward highly potent and selective PDK1 inhibitors via a structure-based design strategy. The most potent and selective inhibitors demonstrated submicromolar activity as measured by inhibition of phosphorylation of PDK1 substrates as well as antiproliferative activity against a subset of AML cell lines. In addition, reduction of phosphorylation of PDK1 substrates was demonstrated in vivo in mice bearing OCl-AML2 xenografts. These observations demonstrate the utility of these molecules as tools to further delineate the biology of PDK1 and the potential pharmacological uses of a PDK1 inhibitor.

Medina, Jesus R.; Becker, Christopher J.; Blackledge, Charles W.; Duquenne, Celine; Feng, Yanhong; Grant, Seth W.; Heerding, Dirk; Li, William H.; Miller, William H.; Romeril, Stuart P.; Scherzer, Daryl; Shu, Arthur; Bobko, Mark A.; Chadderton, Antony R.; Dumble, Melissa; Gardiner, Christine M.; Gilbert, Seth; Liu, Qi; Rabindran, Sridhar K.; Sudakin, Valery; Xiang, Hong; Brady, Pat G.; Campobasso, Nino; Ward, Paris; Axten, Jeffrey M. (GSKPA)

2014-10-02T23:59:59.000Z

408

Activation of reactive oxygen species/AMP activated protein kinase signaling mediates fisetin-induced apoptosis in multiple myeloma U266 cells  

Science Journals Connector (OSTI)

We investigated the molecular mechanisms responsible for fisetin-induced apoptosis in U266 cells. Fisetin elicited the cytotoxicity in U266 cells, manifested as an increased fraction of the cells with sub-G1 content or stained positively with TUNEL labeling. Fisetin enhanced caspase-3 activation, downregulation of Bcl-2 and Mcl-1L, and upregulation of Bax, Bim and Bad. Fisetin activated AMPK as well as its substrate acetyl-CoA carboxylase (ACC), along with a decreased phosphorylation of AKT and mTOR. Fisetin also stimulated generation of ROS in U266 cells. Conversely, compound C or N-acetyl-l-cystein blocked fisetin-induced apoptosis. Our data suggest that fisetin-induced apoptosis in U266 cells is through ROS and AMPK pathways.

Ki Young Jang; Soo-Jin Jeong; Sun-Hee Kim; Ji Hoon Jung; Ji-Hyun Kim; Wonil Koh; Chang-Yan Chen; Sung-Hoon Kim

2012-01-01T23:59:59.000Z

409

Low cost computer interface using eye tracking  

E-Print Network (OSTI)

/ANO PBO/Aa Pe I/AS PB2/AIO Pea/AII PB4/A12 Pea/Aia Pea/AI 4 Per/A15 PAOIIGS e Q 5 ii ( & 0 S MC88HC11A8 Pin Assignments (52 pin PLCC) Q41 ge Qae Q44 /44/ 042 04' fae/ Q4i 038 039 Qa) 089 Qaa 049 /DI 01 03 05 O' SO" 000' 0'0' ~I Oi..., Q? 0? 019 08 /De Q~) 026 Qze Q24 022 Qzo Ga 028 /07 boa 021 Pin assignments for 52- pin chip carrier socket Figure 7. Pin assignments of the microcontroller 24 tor and its line assembler facilities. Later coding and software tests were...

Zee, Bernard Chan Heng

2012-06-07T23:59:59.000Z

410

An analysis of the incomes of rural and urban Spanish-Americans in two South Texas counties  

E-Print Network (OSTI)

LaareawA ef ?hssa??ee, ihe Laoossa Naca ays bssL ah ~ roice. Por eagle, iho eo?iea Lss- o~ tor tassilioe bsa?a? hf yorooaa s?sa ha4 esssylebs4 troa ~ ao fear pare et e?aoetiae ~ Qfll' mac aaaoaDy ibaa for Qsseo tassL+ boe?a s?so 4L4 eeL ~lobe aa meh aa... see year ef mbaol. Liheeiao, ia 8as lssSoaio, ssLQs aho aeey4im ot ihooo Aailg hea?o abet eeayleie? ae ao fear gears ef aoheol, fute+ iaooeoa Laareaao eith ~h e??ihioaal iaarossssA of e? T}l ~ ae?iea Lao~ ef tMtlioo bse?e? bg yotola Oeaylot?ssg 9...

Dickerson, Ben Edward

2012-06-07T23:59:59.000Z

411

A quantitative comparison of An-56477, trifluralin and nitralin losses from soil  

E-Print Network (OSTI)

- ]lnlltolv 100 ml. Dor ndnute A'. )6!i'i7& t c! f]inn '. , ]ill or' rii " 1]ii I'oni, 'lnt of t!io self!I ]tl det orncIiiod by coino z lnl, Deck tlo, , !'I !&j (. Ci'rl. ' cly tile sc':, 0 c: p . ;. s hcirhts proii iron bv !ccrc/I i, "upntl Lire . I' 'hs... Reaainin? Trifluralin Nxr-alan 100 100 100 73 ') 2L; 56. 0 5 3 78. 1 36, I. 70. 1 72 3Q 6 69 o) ' z rcn -:!ri'i a . (er I'roc (he data in tab7e 1 it aprecrs a gl?hr. del!7? be', . !eon r&poli&co?, io? cr&d l?corps&: t!or& ot An-56477 ?c ill ' e...

Behan, Dale Eugene

2012-06-07T23:59:59.000Z

412

mlw8264.tmp  

NLE Websites -- All DOE Office Websites (Extended Search)

,,...... ,,...... sLAc-PuB--5l93 DE90 OO81OO THE E(2S4 CODE SYSTEM: SOLUTION OF GAMMA-RAY AND ELECTRON TRANSPORT PROBLEMS* W. R. NELSON AND YOSHIHITO NAMITO~ Stanford Linear Accelerator Center Stanford University, Stanford, California 94305 Abstract In this paperwe present an overview of the EGS4 Code System-a general purpose package forthe Monte (larlosimulatio no fthetransport of electrons and photons. During the last 10-15 years EGS has been widely used todesignaccelera- tors and detectors for high-energy physics. More recently the code has been found to be of tremendous use in medical radiation physics and dosimetry. The problem- solving capabilities of EGS4 will be demonstrated by means of a variety of practical examples. To facilitate this review, we will take advantage of a new add-on pack- age, called SHO WGRAF, to display particle trajectories in complicated geometries.

413

by Judy Jackson, Office of Public Affairs  

NLE Websites -- All DOE Office Websites (Extended Search)

As he described for a Laboratory As he described for a Laboratory audience the tasks confronting Fermilab in the coming decade, Fermilab Director John Peoples showed a transparency enti- tled "Conceptual Plans for the Future." It listed new particle accelerators and detec- tors that might someday be built at the Laboratory. When a fly landed on the second entry, "Muon Collider," Peoples swatted it away. "Ah!" quipped a member of the audience. "The first collision at a muon collider at Fermilab." The Laboratory has much to accom- plish before any further collisions can occur at a muon collider-or at any Fermilab col- lider, including the Tevatron in Collider Run II. And last week, in a series of meet- ings with members of the Fermilab com- munity, the Laboratory director described

414

Word Pro - Untitled1  

U.S. Energy Information Administration (EIA) Indexed Site

8 8 Crude Oil Domestic First Purchase Prices U.S. Average Prices, 1949-2011 Alaska North Slope, California, and Texas 1977-2011 160 U.S. Energy Information Administration / Annual Energy Review 2011 1 In chained (2005) dollars, calculated by using gross domestic product implicit price defla- tors in Table D1. See "Chained Dollars" in Glossary. 2 See "Nominal Dollars" in Glossary. 3 Alaska North Slope. Source: Table 5.18. Real¹ Nominal² 1950 1955 1960 1965 1970 1975 1980 1985 1990 1995 2000 2005 2010 0 20 40 60 80 100 120 Dollars per Barrel Texas Texas 1980 1985 1990 1995 2000 2005 2010 0 25 50 75 100 125 Nominal Dollars² per Barrel Nominal² Prices 1980 1985 1990 1995 2000 2005 2010 0 100 200 300 400 500 600 100 Index: 1977=100 Real¹ Prices, Indexed 1977=100 ANS³ California Texas 1980

415

Blackout Final Implementation Report  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Report Report on the Implementation of the Task Force Recommendations U.S.-Canada Power System Outage Task Force Natural Resources Canada U.S. Department of Energy September 2006 Final Report on the Implementation of the Task Force Recommendations U.S.-Canada Power System Outage Task Force September 2006 Natural Resources Canada U.S. Department of Energy Acknowledgments This document was prepared by staff of Natural Resources Canada and the U.S. Department of Energy. The principal contributors are listed in Annex 1. The staff wish to acknowledge the contributions of the U.S. Federal Energy Regulatory Commission and the Ontario Ministry of Energy. The staff also wish to acknowl- edge the support and cooperation of the North American Electric Reliability Council and, in particular, of Mr. David Nevius, Senior Vice President and Direc- tor of Reliability Assessment & Performance

416

Office of Inspector General Annual Performance Plan 2011  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Performance Report FY 2010 Performance Report FY 2010 Annual Performance Plan FY 2011 Office of Inspector General DOE/IG-APP012 Annual Performance Report FY 2010 Annual Performance Plan FY 2011 U.S. DEPARTMENT OF ENERGY OFFICE OF INSPECTOR GENERAL II DEPARTMENT OF ENERGY, OFFicE OF iNsPEcTOR GENERAl THIS PAGE INTENTIONALLY LEFT BLANK FY 2010 ANNUAl PERFORMANcE REPORT III Message from the Inspector General I am pleased to submit the Office of Inspector General's combined Fiscal Year 2010 Annual Performance Report and Fiscal Year 2011 Annual Performance Plan. Over the past year, much of our work has centered on oversight of the Department of Energy's efforts under the American Recovery and Investment Act of 2009 (Recovery Act). Under the Recovery Act, the Department of Energy received just

417

Word Pro - Untitled1  

U.S. Energy Information Administration (EIA) Indexed Site

1 Commercial Buildings Electricity Consumption by End Use, 2003 1 Commercial Buildings Electricity Consumption by End Use, 2003 By End Use By Principal Building Activity 64 U.S. Energy Information Administration / Annual Energy Review 2011 1,340 481 436 381 167 156 88 69 24 418 Lighting Cooling Ventilation Refrigeration Space Computers Water Office Cooking Other¹ 0 500 1,000 1,500 Trillion Btu Heating Heating Equipment and Storage Assembly 733 719 371 248 244 235 217 208 167 149 267 Mercantile Office Education Health Care Warehouse Lodging Food Service Food Sales Public Service Other² 0 200 400 600 800 Trillion Btu (Cumulative) All Other End Uses Cooling Lighting 1 Examples of "other" include medical, electronic, and testing equipment; conveyors, wrappers, hoists, and compactors; washers, disposals, dryers, and cleaning equipment; escalators, eleva- tors, dumb waiters, and window washers; shop tools and electronic testing equipment; sign

418

SuperB Bunch-By-Bunch Feedback R&D  

SciTech Connect

The SuperB project has the goal to build in Italy, in the Frascati or Tor Vergata area, an asymmetric e{sup +}/e{sup -} Super Flavor Factory to achieve a peak luminosity > 10**36 cm{sup -2} s{sup -1}. The SuperB design is based on collisions with extremely low vertical emittance beams and high beam currents. A source of emittance growth comes from the bunch by bunch feedback systems producing high power correction signals to damp the beams. To limit any undesirable effect, a large R&D program is in progress, partially funded by the INFN Fifth National Scientific Committee through the SFEED (SuperB Feedback) project approved within the 2010 budget. The SuperB project [1] has the goal to build in Italy, in the Frascati or Tor Vergata area, an asymmetric e{sup +}/e{sup -} Super Flavor Factory to achieve a peak luminosity > 10**36 cm{sup -2} s{sup -1}. In the last and current years, the machine layout has been deeply modified, in particular the main rings are now shorter and an option with high currents has been foreseen. In the fig.1 the new SuperB layout is shown. From bunch-by-bunch feedback point of view, the simultaneous presence in the machine parameters, of very low emittance, of the order of 5-10 pm in the vertical plane, and very high currents, at level of 4 Ampere for the Low Energy Ring, asks for designing very carefully the bunch-by-bunch feedback systems. The parameter list is presented in Fig. 2. The bunch-by-bunch feedback design must take care of the risky and exciting challenges proposed in the SuperB specifications, but it should consider also some other important aspects: flexibility in terms of being able to cope to unexpected beam behaviours [2], [3] legacy of previous version experience [4], [5] and internal powerful diagnostics [6] as in the systems previously used in PEP-II and DAFNE [7].

Drago, A.; Beretta, M.; /Frascati; Bertsche, K.; Novokhatski, A.; /SLAC; Migliorati, M.; /Rome U.

2011-08-12T23:59:59.000Z

419

G  

NLE Websites -- All DOE Office Websites (Extended Search)

OPEN OPEN G OVERNMENT D ATA TOOLKIT 2012 INTERNATIONAL OPEN G OVERNMENT D ATA CONFERENCE (Pre---Alpha V ersion) Amparo B allivian aballivian@worldbank.org Organized b y t he W orld B ank a nd D ata.gov 2012 INTERNATIONAL O PEN G OVERNMENT D ATA C ONFERENCE Toolkit P ieces 2 II. K nowledge repository (virtual) III. I T soluOons IV. D emand for O D / Engagement Tools V. S upply o f Data I. R eadiness Assessment Tool 2012 INTERNATIONAL O PEN G OVERNMENT D ATA C ONFERENCE II. K nowledge R epository * OD i n C ountries * OD i n C iKes * OD i n S ectors * ApplicaKons * Policy/Strategy Documents * CommuniKes o f PracKce * Learning T ools/ PublicaKons * Terms o f U se/ Licensing * TORs * Roster o f E xperts 3 2012 INTERNATIONAL O PEN G OVERNMENT D ATA C ONFERENCE OD i n C ountries Selected Examples * UK

420

s004.dvi  

NLE Websites -- All DOE Office Websites (Extended Search)

µ µ J = 1 2 µ MASS (atomic mass units u) µ MASS (atomic mass units u) µ MASS (atomic mass units u) µ MASS (atomic mass units u) The muon's mass is obtained from the muon-electron mass ratio as deter- mined from the measurement of Zeeman transition frequencies in muonium (µ + e - atom). Since the electron's mass is most accurately known in u, the muon's mass is also most accurately known in u. The conversion fac- tor to MeV has approximately the same relative uncertainty as the mass of the muon in u. In this datablock we give the result in u, and in the following datablock in MeV. VALUE (u) DOCUMENT ID TECN COMMENT 0.1134289267± 0.0000000029 0.1134289267± 0.0000000029 0.1134289267± 0.0000000029 0.1134289267± 0.0000000029 MOHR 12 RVUE 2010 CODATA value * * * We do not use the following data for averages, fits, limits, etc. * * * 0.1134289256± 0.0000000029 MOHR 08 RVUE 2006 CODATA value 0.1134289264±

Note: This page contains sample records for the topic "admi nistra tor" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

s004.dvi  

NLE Websites -- All DOE Office Websites (Extended Search)

4 4 µ J = 1 2 µ MASS (atomic mass units u) µ MASS (atomic mass units u) µ MASS (atomic mass units u) µ MASS (atomic mass units u) NODE=S004AMU The muon's mass is obtained from the muon-electron mass ratio as deter- NODE=S004AMU mined from the measurement of Zeeman transition frequencies in muonium (µ + e - atom). Since the electron's mass is most accurately known in u, the muon's mass is also most accurately known in u. The conversion fac- tor to MeV has approximately the same relative uncertainty as the mass of the muon in u. In this datablock we give the result in u, and in the following datablock in MeV. NODE=S004AMU VALUE (u) DOCUMENT ID TECN COMMENT 0.1134289267 ± 0.0000000029 0.1134289267 ± 0.0000000029 0.1134289267 ± 0.0000000029 0.1134289267 ± 0.0000000029 MOHR 12 RVUE 2010 CODATA value * * * We do not use the following data for averages, fits, limits, etc. * * * 0.1134289256 ± 0.0000000029

422

Microsoft PowerPoint - marmar_overview_10_minute_21.ppt  

NLE Websites -- All DOE Office Websites (Extended Search)

Alcator C-Mod Research Alcator C-Mod Research Presented by E.S. Marmar On behalf of the C-Mod Team APS-DPP07 Paper PO3.001 Work Supported by USDoE Office of Fusion Energy Sciences C-Mod contributions to APS meeting linked from: www.psfc.mit.edu/research/alcator/pubs/index.htm C Mod Alcator - Lower Hybrid Implemented for Current Density Profile Control MSE Diagnostic Measures Changes in j(r) Modeling in Very Good Agreement with Experiment Bonoli: Invited talk, Monday Wilson: This session Parker: Poster this morning 0 2 4 6 8 10 12 14 Current Density (MA / m 2 ) 0 0.2 0.4 0.6 0.8 1 1070828018 J LH - CQL3D (E || =0) J tot - CQL3D Ψ tor ~ (r/a) MSE MSE C Mod Alcator - ICRF Only ICRF Only Density Peaking at Low Collisionality C-Mod Data Help Break Covariance Between ν and n/n

423

This  

Office of Legacy Management (LM)

doc;nzWnt conslztr, of NO. fif 7 copies, Serieeb 3 1, i/ "0 Ihi/ 1 l . . . A &pm& I--' rltti 4-' aimoaf~m?k -0prrtiav Data: P F. Brown' 49 6 0 c ;i @v d _---- __ ,--_ ~-~ ..~.. __l_l ___ - - . . - . . --.", -~ ___-- -- _... - -.-.-- ' / L' / II. - ,sitied 4 (4 I &y . . --,~- e c Brd l * & "4 d t I w l mtlauo A&#ar8u8tfirrt,~~~ly5,~w,~~-' a$d 81th 6w ud m, 6n@--, -*Lllu *~~bla -lr mavlauualbo&lgn~~~tor8m~~88~~ &?aas-11. mda8ta~tlaof~llitiwf~fb,-- iwtilrrOfbroar~8*~bPhU~~~~ mm. ItluJhlamodto~~~trQnf~~u~~ maa. Tbbqlllmnt8lpllotpl8uwtt&8ru8h~lllu8~ d~bqllwwfJ~pllot~efUucllfta-coo wrrbuthpl8adLapmum. Amao8tnatbubma8~l8ta6mltb ~~~~~~.f~fbprodrwtiao~~~l~w~8tl~ m #but bth# April, *, ud Jan) 1w. 8u@.llrrsll mquw

424

L I REQUEST FOR RECORD;CDISPQSITION AUTHORITY  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

# # . L I . REQUEST FOR RECORD;CDISPQSITION AUTHORITY {See I r r ~ t ~ c t ; o n s on ?E3V8r88> 1 TO: NATIONAL A R C H N E S ~ I ~ RECORDS ADMINISTRATION (NIR) WASIiWCTON DC 20408 I I . FROM (&en& or'esrclblishmenc) US. Oepartment o f Energy 2. MAJOR SLIBDIVISJON . I n accordance with rhe provir;ions of 44 U.9.C. 3303a the drsposr~ion request. Southeastern P o ~ e r Administration (388) lncludrng omen4rncnw, k =p roved-except 3 . MINOR SUBDIV~SION tor n s c itexn~ appreved.. rhnr ma o r Lchdrawne be m s r d in *dlo coE2,"g 4. NAME OF PERSON WITH WHOM TO CONFER 5. TELEPHONE Carol M. Franklin 6. AGENCY CE'RTIFICATION I hereby thar 1 am authorized to act for and that the records roposed for dispwal on of this ag.ncy or J n o t be needad after the the General Accounting Office, under rhe pro

425

Quality Assurance Exchange, October 2008  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

4 4 , I s s u e 2 O c t o b e r 2 0 0 8 I N S I D E T H I S I S S U E : In the Spotlight: Larry Newman, Director of the Office of Quality Assurance, OCRWM 1 SQA Work Activity: Personnel Training in Design, Development, Use & Evaluation of Safety Software 4 Safety Bulletin: Quality Assurance Concern Wright Industries, Inc. 5 HSS QA Activity Corner 6 Just for Fun 7 QA-Related Meetings & Conferences 8 Director's Note 8 Q U A L I T Y A S S U R A N C E E X C H A N G E Mr. Larry Newman has broad experience in managing nuclear reactors and power plants, both in the government and the private sec- tor. He has over 20 years' experience in the civilian nuclear field. He has worked at nu- merous civilian nuclear power reactors, where he has twice been a Nuclear Regula- tory Commission (NRC)-licensed senior re-

426

Alcator C-Mod Program C Mod Alcator  

NLE Websites -- All DOE Office Websites (Extended Search)

Program Program C Mod Alcator - Program Science Objectives Hutchinson 15m Budget, Schedules, and Manpower Marmar 20 MIT Institutional Issues Porkolab 10 OFES Budget Planning Meeting, Gaithersburg, Mar 2003 C Mod Alcator - Program Exploits Unique Features of the C-Mod Tokamak Major thrusts: Quasi-steady Advanced Tokamak: utilizing long pulse length cf L/R, new LH facility. Burning Plasma Support: High B; reactor pressure, q ; i-e coupled; Mo PFCs. Unique dimensional parameters give special relevance to topical science research: Transport: Marginal stability, pedestal, electron transp. Edge/Divertor: SOL transport, Neutrals, Power handling. Wave/Particle: Purely RF driven. ICRF, LH physics. MHD: Active MHD spectroscopy. ICRF/LH stabilization. C Mod Alcator - Momentum Transport Without Sources 0.50 0.55 0.60 0.65 0.70 0.75 0.80 0.85 -1 0 1 2 3 4 V Tor (10 4 m/s) 0.6 0.3 0.0 0.50

427

An nual En ergy Re view 2001  

Gasoline and Diesel Fuel Update (EIA)

An nual En ergy Re view 2001 An nual En ergy Re view 2001 The An nual En ergy Re view (AER) pres ents the En ergy In for ma tion Ad min - is tra tion's his tor i cal en ergy sta tis tics. For many se ries, sta tis tics are given for ev ery year from 1949 through 2001. The sta tis tics, ex pressed in ei ther phys i cal units or Brit ish ther mal units, cover all ma jor en ergy ac tiv i ties, in - clud ing con sump tion, pro duc tion, trade, stocks, and prices, for all ma jor en - ergy com mod i ties, in clud ing fos sil fu els, elec tric ity, and re new able en ergy sources. Pub li ca tion of this re port is re quired un der Pub lic Law 95-91 (De part ment of En ergy Or ga ni za tion Act), Sec tion 205(c), and is in keep ing with re spon - si bil i ties given to the En ergy In for ma tion Ad min is tra tion un der Sec tion

428

INFORMAL REPORT  

NLE Websites -- All DOE Office Websites (Extended Search)

q?% q?% LA-5031 -MS INFORMAL REPORT krs $ 1 0 s N o t e on Inverse Bremsstrahlung in Strong E!ect:omGgnetic c;alPl I j a l a m o s scientific laboratory of the University of California LOS A L A M O S , NEW MEXICO 8 7 5 4 4 U N I T E D S T A T E S A T O M I C E N E R G Y C O M M I S S I O N a This report was prepared as an account of work sponsored by the United States Government. Neither the United States nor the United States Atomic Energy Commission, nor any of their employees, nor any of their contrac- tors, subcontractors, or their employees, makes any warranty, express or im- plied, or assumes any legal liability or responsibility for the accuracy, com- pleteness or usefulness of any information, apparatus, product or process dis- closed, or represents that its use would not infringe privately owned rights.

429

Parameter Identification and On-line Estimation of a Reduced Kinetic Model  

SciTech Connect

In this work, we present the estimation techniques used to update the model parameters in a reduced kinetic model describing the oxidation-reduction re- actions in a hydrothermal oxidation reactor. The model is used in a nonlinear model-based controller that minimizes the total aqueous nitrogen in the reac- tor effluent. Model reduction is accomplished by com- bining similar reacting compounds into one of four component groups and considering the global reac- tion pathways for each of these groups. The reduced kinetic model developed for thk reaction system pro- vides a means to characterize the complex chemical reaction system without considering each chemicaJ species present and the reaction kinetics of every pos- sible reaction pathway. For the reaction system under study, model reduction is essential in order to reduce the computational requirement so that on-line imple- mentation of the nonlinear model-based controller is possible and also to reduce the amount of a priori information required for the model.

Dellorco, P.C.; Flesner, R.L.; Le, L.A.; Littell, J.D.; Muske, K.R.

1999-02-01T23:59:59.000Z

430

SuperB Technical Design Report  

E-Print Network (OSTI)

In this Technical Design Report (TDR) we describe the SuperB detector that was to be installed on the SuperB e+e- high luminosity collider. The SuperB asymmetric collider, which was to be constructed on the Tor Vergata campus near the INFN Frascati National Laboratory, was designed to operate both at the Upsilon(4S) center-of-mass energy with a luminosity of 10^{36} cm^{-2}s^{-1} and at the tau/charm production threshold with a luminosity of 10^{35} cm^{-2}s^{-1}. This high luminosity, producing a data sample about a factor 100 larger than present B Factories, would allow investigation of new physics effects in rare decays, CP Violation and Lepton Flavour Violation. This document details the detector design presented in the Conceptual Design Report (CDR) in 2007. The R&D and engineering studies performed to arrive at the full detector design are described, and an updated cost estimate is presented. A combination of a more realistic cost estimates and the unavailability of funds due of the global economic ...

Baszczyk, M; Kolodziej, J; Kucewicz, W; Sapor, M; Jeremie, A; Pous, E Grauges; Bruno, G E; De Robertis, G; Diacono, D; Donvito, G; Fusco, P; Gargano, F; Giordano, F; Loddo, F; Loparco, F; Maggi, G P; Manzari, V; Mazziotta, M N; Nappi, E; Palano, A; Santeramo, B; Sgura, I; Silvestris, L; Spinoso, V; Eigen, G; Zalieckas, J; Zhuo, Z; Jenkovszky, L; Balbi, G; Boldini, M; Bonacorsi, D; Cafaro, V; D'Antone, I; Dallavalle, G M; Di Sipio, R; Fabbri, F; Fabbri, L; Gabrielli, A; Galli, D; Giacomelli, P; Giordano, V; Giorgi, F M; Grandi, C; Lax, I; Meo, S Lo; Marconi, U; Montanari, A; Pellegrini, G; Piccinini, M; Rovelli, T; Cesari, N Semprini; Torromeo, G; Tosi, N; Travaglini, R; Vagnoni, V M; Valentinetti, S; Villa, M; Zoccoli, A; Caron, J -F; Hearty, C; Lu, P F -T; Mattison, T S; McKenna, J A; So, R Y -C; Barnyakov, M Yu; Blinov, V E; Botov, A A; Druzhinin, V P; Golubev, V B; Kononov, S A; Kravchenko, E A; Levichev, E B; Onuchin, A P; Serednyakov, S I; Shtol, D A; Skovpen, Y I; Solodov, E P; Cardini, A; Carpinelli, M; Chao, D S -T; Cheng, C H; Doll, D A; Echenard, B; Flood, K; Hanson, J; Hitlin, D G; Ongmongkolkul, P; Porter, F C; Zhu, R Y; Randazzo, N; Burelo, E De La Cruz; Zheng, Y; Campos, P; De Silva, M; Kathirgamaraju, A; Meadows, B; Pushpawela, B; Shi, Y; Sokoloff, M; Castro, G Lopez; Ciaschini, V; Franchini, P; Giacomini, F; Paolini, A; Polania, G A Calderon; Laczek, S; Romanowicz, P; Szybinski, B; Czuchry, M; Flis, L; Harezlak, D; Kocot, J; Radecki, M; Sterzel, M; Szepieniec, T; Szymocha, T; Wójcik, P; Andreotti, M; Baldini, W; Calabrese, R; Carassiti, V; Cibinetto, G; Ramusino, A Cotta; Evangelisti, F; Gianoli, A; Luppi, E; Malaguti, R; Manzali, M; Melchiorri, M; Munerato, M; Padoan, C; Santoro, V; Tomassetti, L; Beretta, M M; Biagini, M; Boscolo, M; Capitolo, E; de Sangro, R; Esposito, M; Felici, G; Finocchiaro, G; Gatta, M; Gatti, C; Guiducci, S; Lauciani, S; Patteri, P; Peruzzi, I; Piccolo, M; Raimondi, P; Rama, M; Sanelli, C; Tomassini, S; Fabbricatore, P; Delepine, D; Santos, M A Reyes; Chrzaszcz, M; Grzymkowski, R; Knap, P; Kotula, J; Lesiak, T; Ludwin, J; Michalowski, J; Pawlik, B; Rachwal, B; Stodulski, M; Wiechczynski, J; Witek, M; Zawiejski, L; Zdybal, M; Aushev, V Y; Ustynov, A; Arnaud, N; Bambade, P; Beigbeder, C; Bogard, F; Borsato, M; Breton, D; Brossard, J; Burmistrov, L; Charlet, D; Chaumat, V; Dadoun, O; Berni, M El; Maalmi, J; Puill, V; Rimbault, C; Stocchi, A; Tocut, V; Variola, A; Wallon, S; Wormser, G; Grancagnolo, F; Ben-Haim, E; Sitt, S; Baylac, M; Bourrion, O; Deconto, J -M; Martinez, Y Gomez; Monseu, N; Muraz, J -F; Real, J -S; Vescovi, C; Cenci, R; Jawahery, A; Roberts, D; Twedt, E W; Cheaib, R; Lindemann, D; Nderitu, S; Patel, P; Robertson, S H; Swersky, D; Warburton, A; Flores, E Cuautle; Sanchez, G Toledo; Biassoni, P; Bombelli, L; Citterio, M; Coelli, S; Fiorini, C; Liberali, V; Monti, M; Nasri, B; Neri, N; Palombo, F; Sabatini, F; Stabile, A; Berra, A; Giachero, A; Gotti, C; Lietti, D; Maino, M; Pessina, G; Prest, M; Martin, J -P; Simard, M; Starinski, N; Taras, P; Drutskoy, A; Makarychev, S; Nefediev, A V; Aloisio, A; Cavaliere, S; De Nardo, G; Della Pietra, M; Doria, A; Giordano, R; Ordine, A; Pardi, S; Russo, G; Sciacca, C; Bigi, I I; Jessop, C P; Wang, W; Bellato, M; Benettoni, M; Corvo, M; Crescente, A; Corso, F Dal; Dosselli, U; Fanin, C; Gianelle, A; Longo, S; Michelotto, M; Montecassiano, F; Morandin, M; Pengo, R; Posocco, M; Rotondo, M; Simi, G; Stroili, R; Gaioni, L; Manazza, A; Manghisoni, M; Ratti, L; Re, V; Traversi, G; Zucca, S; Bizzaglia, S; Bizzarri, M; Cecchi, C; Germani, S; Lebeau, M; Lubrano, P; Manoni, E; Papi, A; Rossi, A; Scolieri, G; Batignani, G; Bettarini, S; Casarosa, G; Cervelli, A; Fella, A; Forti, F; Giorgi, M; Lilli, L; Lusiani, A; Oberhof, B; Paladino, A; Pantaleo, F; Paoloni, E; Perez, A L Perez; Rizzo, G; Walsh, J; Téllez, A Fernández; Beck, G; Berman, M; Bevan, A; Gannaway, F; Inguglia, G; Martin, A J; Morris, J; Bocci, V; Capodiferro, M; Chiodi, G; Dafinei, I; Drenska, N V; Faccini, R; Ferroni, F; Gargiulo, C; Gauzzi, P; Luci, C; Lunadei, R; Martellotti, G; Pellegrino, F; Pettinacci, V; Pinci, D; Recchia, L; Ruggeri, D; Zullo, A; Camarri, P; Cardarelli, R; De Santis, C; Di Ciaccio, A; Di Felice, V; Di Palma, F; Di Simone, A; Marcelli, L; Messi, R; Moricciani, D; Sparvoli, R; Tammaro, S; Branchini, P; Budano, A; Bussino, S; Ciuchini, M; Nguyen, F; Passeri, A; Ruggieri, F; Spiriti, E; Wilson, F; Monzon, I Leon; Millan-Almaraz, J R; Podesta-Lerma, P L M; Aston, D; Dey, B; Fisher, A; Jackson, P D; Leith, D W G S; Luitz, S; MacFarlane, D; McCulloch, M; Metcalfe, S; Novokhatski, A; Osier, S; Prepost, R; Ratcliff, B; Seeman, J; Sullivan, M; Va'vra, J; Wienands, U; Wisniewski, W; Altschul, B D; Purohit, M V; Baudot, J; Ripp-Baudot, I; Cirrone, G A P; Cuttone, G; Bezshyyko, O; Dolinska, G; Soffer, A

2013-01-01T23:59:59.000Z

431

SuperB Technical Design Report  

E-Print Network (OSTI)

In this Technical Design Report (TDR) we describe the SuperB detector that was to be installed on the SuperB e+e- high luminosity collider. The SuperB asymmetric collider, which was to be constructed on the Tor Vergata campus near the INFN Frascati National Laboratory, was designed to operate both at the Upsilon(4S) center-of-mass energy with a luminosity of 10^{36} cm^{-2}s^{-1} and at the tau/charm production threshold with a luminosity of 10^{35} cm^{-2}s^{-1}. This high luminosity, producing a data sample about a factor 100 larger than present B Factories, would allow investigation of new physics effects in rare decays, CP Violation and Lepton Flavour Violation. This document details the detector design presented in the Conceptual Design Report (CDR) in 2007. The R&D and engineering studies performed to arrive at the full detector design are described, and an updated cost estimate is presented. A combination of a more realistic cost estimates and the unavailability of funds due of the global economic climate led to a formal cancelation of the project on Nov 27, 2012.

SuperB Collaboration; M. Baszczyk; P. Dorosz; J. Kolodziej; W. Kucewicz; M. Sapor; A. Jeremie; E. Grauges Pous; G. E. Bruno; G. De Robertis; D. Diacono; G. Donvito; P. Fusco; F. Gargano; F. Giordano; F. Loddo; F. Loparco; G. P. Maggi; V. Manzari; M. N. Mazziotta; E. Nappi; A. Palano; B. Santeramo; I. Sgura; L. Silvestris; V. Spinoso; G. Eigen; J. Zalieckas; Z. Zhuo; L. Jenkovszky; G. Balbi; M. Boldini; D. Bonacorsi; V. Cafaro; I. D'Antone; G. M. Dallavalle; R. Di Sipio; F. Fabbri; L. Fabbri; A. Gabrielli; D. Galli; P. Giacomelli; V. Giordano; F. M. Giorgi; C. Grandi; I. Lax; S. Lo Meo; U. Marconi; A. Montanari; G. Pellegrini; M. Piccinini; T. Rovelli; N. Semprini Cesari; G. Torromeo; N. Tosi; R. Travaglini; V. M. Vagnoni; S. Valentinetti; M. Villa; A. Zoccoli; J. -F. Caron; C. Hearty; P. F. -T. Lu; T. S. Mattison; J. A. McKenna; R. Y. -C. So; M. Yu. Barnyakov; V. E. Blinov; A. A. Botov; V. P. Druzhinin; V. B. Golubev; S. A. Kononov; E. A. Kravchenko; E. B. Levichev; A. P. Onuchin; S. I. Serednyakov; D. A. Shtol; Y. I. Skovpen; E. P. Solodov; A. Cardini; M. Carpinelli; D. S. -T. Chao; C. H. Cheng; D. A. Doll; B. Echenard; K. Flood; J. Hanson; D. G. Hitlin; P. Ongmongkolkul; F. C. Porter; R. Y. Zhu; N. Randazzo; E. De La Cruz Burelo; Y. Zheng; P. Campos; M. De Silva; A. Kathirgamaraju; B. Meadows; B. Pushpawela; Y. Shi; M. Sokoloff; G. Lopez Castro; V. Ciaschini; P. Franchini; F. Giacomini; A. Paolini; G. A. Calderon Polania; S. Laczek; P. Romanowicz; B. Szybinski; M. Czuchry; L. Flis; D. Harezlak; J. Kocot; M. Radecki; M. Sterzel; T. Szepieniec; T. Szymocha; P. Wójcik; M. Andreotti; W. Baldini; R. Calabrese; V. Carassiti; G. Cibinetto; A. Cotta Ramusino; F. Evangelisti; A. Gianoli; E. Luppi; R. Malaguti; M. Manzali; M. Melchiorri; M. Munerato; C. Padoan; V. Santoro; L. Tomassetti; M. M. Beretta; M. Biagini; M. Boscolo; E. Capitolo; R. de Sangro; M. Esposito; G. Felici; G. Finocchiaro; M. Gatta; C. Gatti; S. Guiducci; S. Lauciani; P. Patteri; I. Peruzzi; M. Piccolo; P. Raimondi; M. Rama; C. Sanelli; S. Tomassini; P. Fabbricatore; D. Delepine; M. A. Reyes Santos; M. Chrzaszcz; R. Grzymkowski; P. Knap; J. Kotula; T. Lesiak; J. Ludwin; J. Michalowski; B. Pawlik; B. Rachwal; M. Stodulski; J. Wiechczynski; M. Witek; L. Zawiejski; M. Zdybal; V. Y. Aushev; A. Ustynov; N. Arnaud; P. Bambade; C. Beigbeder; F. Bogard; M. Borsato; D. Breton; J. Brossard; L. Burmistrov; D. Charlet; V. Chaumat; O. Dadoun; M. El Berni; J. Maalmi; V. Puill; C. Rimbault; A. Stocchi; V. Tocut; A. Variola; S. Wallon; G. Wormser; F. Grancagnolo; E. Ben-Haim; S. Sitt; M. Baylac; O. Bourrion; J. -M. Deconto; Y. Gomez Martinez; N. Monseu; J. -F. Muraz; J. -S. Real; C. Vescovi; R. Cenci; A. Jawahery; D. Roberts; E. W. Twedt; R. Cheaib; D. Lindemann; S. Nderitu; P. Patel; S. H. Robertson; D. Swersky; A. Warburton; E. Cuautle Flores; G. Toledo Sanchez; P. Biassoni; L. Bombelli; M. Citterio; S. Coelli; C. Fiorini; V. Liberali; M. Monti; B. Nasri; N. Neri; F. Palombo; F. Sabatini; A. Stabile; A. Berra; A. Giachero; C. Gotti; D. Lietti; M. Maino; G. Pessina; M. Prest; J. -P. Martin; M. Simard; N. Starinski; P. Taras; A. Drutskoy; S. Makarychev; A. V. Nefediev; A. Aloisio; S. Cavaliere; G. De Nardo; M. Della Pietra; A. Doria; R. Giordano; A. Ordine; S. Pardi; G. Russo; C. Sciacca; I. I. Bigi; C. P. Jessop; W. Wang; M. Bellato; M. Benettoni; M. Corvo; A. Crescente; F. Dal Corso; U. Dosselli; C. Fanin; A. Gianelle; S. Longo; M. Michelotto; F. Montecassiano; M. Morandin; R. Pengo; M. Posocco; M. Rotondo; G. Simi; R. Stroili; L. Gaioni; A. Manazza; M. Manghisoni; L. Ratti; V. Re; G. Traversi; S. Zucca; S. Bizzaglia; M. Bizzarri; C. Cecchi; S. Germani; M. Lebeau; P. Lubrano; E. Manoni; A. Papi; A. Rossi; G. Scolieri; G. Batignani; S. Bettarini; G. Casarosa; A. Cervelli; A. Fella; F. Forti; M. Giorgi; L. Lilli; A. Lusiani; B. Oberhof; A. Paladino; F. Pantaleo; E. Paoloni; A. L. Perez Perez; G. Rizzo; J. Walsh; A. Fernández Téllez; G. Beck; M. Berman; A. Bevan; F. Gannaway; G. Inguglia; A. J. Martin; J. Morris; V. Bocci; M. Capodiferro; G. Chiodi; I. Dafinei; N. V. Drenska; R. Faccini; F. Ferroni; C. Gargiulo; P. Gauzzi; C. Luci; R. Lunadei; G. Martellotti; F. Pellegrino; V. Pettinacci; D. Pinci; L. Recchia; D. Ruggeri; A. Zullo; P. Camarri; R. Cardarelli; C. De Santis; A. Di Ciaccio; V. Di Felice; F. Di Palma; A. Di Simone; L. Marcelli; R. Messi; D. Moricciani; R. Sparvoli; S. Tammaro; P. Branchini; A. Budano; S. Bussino; M. Ciuchini; F. Nguyen; A. Passeri; F. Ruggieri; E. Spiriti; F. Wilson; I. Leon Monzon; J. R. Millan-Almaraz; P. L. M. Podesta-Lerma; D. Aston; B. Dey; A. Fisher; P. D. Jackson; D. W. G. S. Leith; S. Luitz; D. MacFarlane; M. McCulloch; S. Metcalfe; A. Novokhatski; S. Osier; R. Prepost; B. Ratcliff; J. Seeman; M. Sullivan; J. Va'vra; U. Wienands; W. Wisniewski; B. D. Altschul

2013-06-24T23:59:59.000Z

432

Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex  

Science Journals Connector (OSTI)

Summary The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a sensor of different environmental conditions and regulator of cell growth, metabolism, and autophagy. mTORC1 is activated by Rag GTPases, working as RagA:RagB and RagC:RagD heterodimers. Rags control mTORC1 activity by tethering mTORC1 to the lysosomes where it is activated by Rheb GTPase. RagA:RagB, active in its GTP-bound form, is inhibited by GATOR1 complex, a GTPase-activating protein, and GATOR1 is in turn negatively regulated by GATOR2 complex. Sestrins are stress-responsive proteins that inhibit mTORC1 via activation of AMP-activated protein kinase (AMPK) and tuberous sclerosis complex. Here we report an AMPK-independent mechanism of mTORC1 inhibition by Sestrins mediated by their interaction with GATOR2. As a result of this interaction, the Sestrins suppress mTOR lysosomal localization in a Rag-dependent manner. This mechanism is potentially involved in mTORC1 regulation by amino acids, rotenone, and tunicamycin, connecting stress response with mTORC1 inhibition.

Anita Parmigiani; Aida Nourbakhsh; Boxiao Ding; Wei Wang; Young Chul Kim; Konstantin Akopiants; Kun-Liang Guan; Michael Karin; Andrei V. Budanov

2014-01-01T23:59:59.000Z

433

Development of biomarkers in an integrated approach to environmental studies  

Science Journals Connector (OSTI)

This study was conducted in a contained environment in order to develop biomarkers and to evaluate the environmental damage after a release of two different toxic substances which are widely used in industrial production. In a simulation study performed in Tor Mancina area (near Rome, Italy), two dangerous substances (formaldehyde and bromine) were tested. Chemical and physical characterisation, nutritive and organic contents, and trace elements presence were also investigated. The contamination effects on soil functional qualities and plant nutrition were evaluated; furthermore DNA damage with short-term genotoxicity tests and DNA biosensor on polluted soils and gravitational water, was detected. The genotoxic effects were evaluated on Vicia faba seedlings by two different short-term tests: comet assay and micronuclei test. A DNA-based biosensor for the detection of genotoxic compounds in soil samples was assembled by immobilising double stranded calf thymus DNA on screen-printed electrodes. An agreement between the comet assay and the other methodologies was observed. The results showed that the nature and the concentration of the two substances result in different molecular interaction with exposed environment. Furthermore, some of the chemical physical parameters considered are applicable indicators for the evaluation of the soilâ??plant system pollution.

Elena Sturchio; Priscilla Boccia; Miriam Zanellato; Claudio Beni; Graziana Bagni; Marco Mascini; Mario Pezzella

2007-01-01T23:59:59.000Z

434

NEPA COMPLIANCE SURVEY  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

5 5 Project lnfonnation Project Title: Repair flowline 100 feet North of 71-3-SX-3 Date: 2-16-2010 DOE Code: Contractor Code: Project Lead: Rick Mclaughlin Project Overview Emergency Repair tor a "owline leak north of 71-3-SX-3. Dug up pipeline, repaired line and backfilled with 1. What are the environmental impacts? clean fill dirt. Oil contaminated soH was hauled to the east side landfarm and dean dirt was brought in from section 20. 2 What 1s the legal location? 3. What is the duration of the project? North of 71-3-SX-3. N43 1 7'53 6~ W. 10611'49.3" 4. What major equipment will be used Approximately 4 hours if any (work over rig, drilling rig, etc.)? Backhoe with operator and one wor1

435

NEPA COMPLIANCE SURVEY  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

WS' ~S5 WS' ~S5 Project Informa tion Proje ct Title: ESP ShuttleS Date: 11-23-09 DOE Code: 71086 Contrac tor Code : 8067-737 Project Lead: fr~V.. Project Ove rview We will be circulatlng water from a cased hole with a plug on bottom. to surface tanks, and back downhole. 1. What are the environmental impacts? A closed system. Frac Master tanks, a generator. esp power equipment and surface plumbing will be in place temporarily. There will be daily traffic for a 2 week period during testing. 2. What is the legaf location? 3. What is the duration of the project? Weii56-LX(MX)-1 0 in the SW SE of sec 10, T38N, R78W 4. What major equipment will be used if any (work over rig, drilling ng., 2Weeks etc.)? Work over rig, smeal,generator, forklift. The table below is to be completed by the Project Lead and reviewed by the Environme

436

Tumor-Selective Response to Antibody-Mediated Targeting of ?v?3 Integrin in Ovarian Cancer  

Science Journals Connector (OSTI)

Abstract The ?v?3 integrin is expressed on proliferating endothelial cells and some cancer cells, but its expression on ovarian cancer cells and its potential as a therapeutic target are unknown. In this study, expression of the ?v?3 integrin on ovarian cancer cell lines and murine endothelial cells was tested, and the effect of a fully humanized monoclonal antibody against ?v?3, Abegrin (etaracizumab), on cell invasion, viability, tumor growth, and the Akt pathway were examined in vitro and in vivo. We found that etaracizumab recognizes ?v?3 on the ovarian cancer cell lines SKOV3ip1, HeyA8, and \\{A2780ip2\\} (at low levels) but not on murine endothelial cells. Etaracizumab treatment decreased ovarian cancer proliferation and invasion. In vivo, tumor-bearing mice treated with etaracizumab alone gave variable results. There was no effect on \\{A2780ip2\\} growth, but a 36% to 49% tumor weight reduction in the \\{SKOV3ip1\\} and HeyA8 models was found (P < .05). However, combined etaracizumab and paclitaxel was superior to paclitaxel in the \\{SKOV3ip1\\} and \\{A2780ip2\\} models (by 51–73%, P < .001) but not in the HeyA8 model. Treatment with etaracizumab was then noted to decrease p-Akt and p-mTOR in SKOV3ip1, but not in HeyA8, which is Akt-independent. Tumors resected after therapy showed that etaracizumab treatment reduced the proliferating cell nuclear antigen index but not microvessel density. This study identifies tumor cell ?v?3 integrin as an attractive target and defines the Akt pathway as a predictor of response to function-blocking antibody.

Charles N. Landen; Tae-Jin Kim; Yvonne G. Lin; William M. Merritt; Aparna A. Kamat; Liz Y. Han; Whitney A. Spannuth; Alpa M. Nick; Nicholas B. Jennnings; Michael S. Kinch; David Tice; Anil K. Sood

2008-01-01T23:59:59.000Z

437

Delphinidin inhibits cell proliferation and invasion via modulation of Met receptor phosphorylation  

SciTech Connect

The HGF/Met signaling pathway is deregulated in majority of cancers and is associated with poor prognosis in breast cancer. Delphinidin, present in pigmented fruits and vegetables possesses potent anti-oxidant, anti-inflammatory and anti-angiogenic properties. Here, we assessed the anti-proliferative and anti-invasive effects of delphinidin on HGF-mediated responses in the immortalized MCF-10A breast cell line. Treatment of cells with delphinidin prior to exposure to exogenous HGF resulted in the inhibition of HGF-mediated (i) tyrosyl-phosphorylation and increased expression of Met receptor, (ii) phosphorylation of downstream regulators such as FAK and Src and (iii) induction of adaptor proteins including paxillin, Gab-1 and GRB-2. In addition, delphinidin treatment resulted in significant inhibition of HGF-activated (i) Ras-ERK MAPKs and (ii) PI3K/AKT/mTOR/p70S6K pathways. Delphinidin was found to repress HGF-activated NF{kappa}B transcription with a decrease in (i) phosphorylation of IKK{alpha}/{beta} and I{kappa}B{alpha}, and (ii) activation and nuclear translocation of NF{kappa}B/p65. Inhibition of HGF-mediated membrane translocation of PKC{alpha} as well as decreased phosphorylation of STAT3 was further observed in delphinidin treated cells. Finally, decreased cell viability of Met receptor expressing breast cancer cells treated with delphinidin argues for a potential role of the agent in the prevention of HGF-mediated activation of various signaling pathways implicated in breast cancer.

Syed, Deeba N.; Afaq, Farrukh; Sarfaraz, Sami; Khan, Naghma; Kedlaya, Rajendra; Setaluri, Vijayasaradhi [Department of Dermatology, University of Wisconsin, Madison (United States); Mukhtar, Hasan [Department of Dermatology, University of Wisconsin, Madison (United States)], E-mail: hmukhtar@wisc.edu

2008-08-15T23:59:59.000Z

438

Research in High Energy Physics at Duke University  

SciTech Connect

This is the Closeout Report for the research grant in experimental elementary particle physics, carried out by the Duke University High Energy Physics (HEP) group. We re- port on physics results and detector development carried out under this grant, focussing on the recent three-year grant period (2010 to 2013). The Duke HEP group consisted of seven faculty members, two senior scientists, #12;ve postdocs and eight graduate students. There were three thrusts of the research program. Measurements at the energy frontier at CDF and ATLAS were used to test aspects of elementary particle theory described by the Stan- dard Model (SM) and to search for new forces and particles beyond those contained within the SM. The neutrino sector was explored using data obtained from a large neutrino detector located in Japan, and R & D was conducted on new experiments to be built in the US. The measurements provided information about neutrino masses and the manner in which neutri- nos change species in particle beams. Two years ago we have started a new research program in rare processes based on the Mu2E experiment at Fermilab. This research is motivated by the search for the #22; ! e transition with unprecedented sensitivity, a transition forbidden in the standard model but allowed in supersymmetric and other models of new physics. The high energy research program used proton and antiproton colliding beams. The experiments were done at the Fermilab Tevatron (proton-antiproton collisions at a center of mass energy of 1.96 TeV) and at the CERN Large Hadron Collider (proton-proton collisions at 7-8 TeV). The neutrino program used data obtained from the Super-Kamiokande detec- tor. This water-#12;lled Cherenkov counter was used to detect and measure the properties of neutrinos produced in cosmic ray showers, and from neutrino beams produced from acceler- ators in Japan. The Mu2E experiment will use a special stopped muon beam to be built at Fermilab.

Kotwal, Ashutosh V. [PI] [PI; Goshaw, Al [Co-PI] [Co-PI; Kruse, Mark [Co-PI] [Co-PI; Oh, Seog [Co-PI] [Co-PI; Scholberg, Kate [Co-PI] [Co-PI; Walter, Chris [Co-PI] [Co-PI

2013-07-29T23:59:59.000Z

439

To Crack or Not to Crack: Strain in High TemperatureSuperconductors  

SciTech Connect

Round wire Bi 2212 is emerging as a viable successor ofNb3Sn in High Energy Physics and Nuclear Magnetic Resonance, to generatemagnetic fields that surpass the intrinsic limitations of Nb3Sn. Ratherbold claims are made on achievable magnetic fields in applications usingBi 2212, due to the materials' estimated critical magnetic field of 100 Tor higher. High transport currents in high magnetic fields, however, leadto large stress on, and resulting large strain in the superconductor. Theeffect of strain on the critical properties of Bi-2212 is far fromunderstood, and strain is, as with Nb3Sn, often treated as a secondaryparameter in the design of superconducting magnets. Reversibility of thestrain induced change of the critical surface of Nb3Sn, points to anelectronic origin of the observed strain dependence. Record breaking highfield magnets are enabled by virtue of such reversible behavior. Straineffects on the critical surface of Bi-2212, in contrast, are mainlyirreversible and suggest a non-electronic origin of the observed straindependence, which appears to be dominated by the formation of cracks inthe superconductor volumes. A review is presented of available results onthe effects of strain on the critical surface of Bi-2212, Bi-2223 andYBCO. It is shown how a generic behavior emerges for the (axial) straindependence of the critical current density, and how the irreversiblereduction of the critical current density is dominated by strain inducedcrack formation in the superconductor. From this generic model it becomesclear that magnets using high temperature superconductors will be strainlimited far before the intrinsic magnetic field limitations will beapproached, or possibly even before the magnetic field limitation ofNb3Sn can be surpassed. On a positive note, in a very promising recentresult from NIST on the axial strain dependence of the critical currentdensity in extremely well aligned YBCO, reversible behavior was observed.This result emphasizes the need for further conductor development,specifically for round wire Bi-2212, to generate a wire with a similarreversible dependence on strain. Availability of such a wire will enablethe construction of magnets that can indeed generate fields that farsurpass the limitations of Nb3Sn superconductors.

Godeke, Arno

2007-08-22T23:59:59.000Z

440

2-Methoxyestradiol, an Endogenous Estrogen Metabolite, Sensitizes Radioresistant MCF-7/FIR Breast Cancer Cells Through Multiple Mechanisms  

SciTech Connect

Purpose: The requirement for a well-tolerated and highly effective radiosensitizer that preferentially sensitizes tumor cells at multiple levels of radioresistance remains largely unmet. 2-Methoxyestradiol (2ME) has polypharmacological profiles that target multiple signaling pathways involved in the development of radioresistance. In the current study, we investigated the radiosensitizing effect of 2ME on the radioresistant breast cancer MCF-7/FIR cell line and explored the underlying mechanisms. Methods and Materials: The radiosensitizing effect of 2ME was evaluated on the basis of cell death and clonogenic survival. Formation of reactive oxygen species (ROS), apoptosis, and cell cycle progression were assessed by flow cytometry. Radiation-induced DNA damage was evaluated on the basis of histone {gamma}-H2AX phosphorylation and foci formation. Immunoblotting was used to assess the effects of {gamma} radiation and/or 2ME on radioresistance pathways. Results: Our data demonstrate that MCF-7/FIR cells expressed higher levels of Bcl-2 and HIF-1{alpha} and displayed a lower ROS phenotype than the parental MCF-7 cells. Treatment of parental MCF-7 cells with 2ME (0.5 {mu}M) had minimal effect on {gamma} radiation-induced cell proliferation and surviving fractions. On the contrary, in MCF-7/FIR cells, treatment with 2ME significantly enhanced {gamma} radiation-induced reduction in cell proliferation and surviving fraction. This combination was effective in activating apoptosis, arresting the cell cycle at the G{sub 2}/M phase, and increasing the level of {gamma} radiation-induced ROS and the number of {gamma}-H2AX foci. In addition, 2ME significantly ameliorated {gamma} radiation-induced expression of the HIF-1{alpha} transcription factor and its downstream targets AKT/mTOR. Conclusion: 2ME preferentially sensitizes radioresistant MCF-7/FIR cells to {gamma} radiation by targeting multiple signaling pathways involved in the development of radioresistance. This polypharmacological profile qualifies 2ME as a promising radiosensitizer in the treatment of radioresistant breast cancer cells and warrants systematic preclinical and clinical studies.

Salama, Salama, E-mail: salama@bcm.ed [Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Baylor College of Medicine, Houston, Texas (United States); Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas (United States); Diaz-Arrastia, Concepcion; Patel, Deepa; Botting, Shaleen [Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Baylor College of Medicine, Houston, Texas (United States); Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas (United States); Hatch, Sandra [Department of Radiation Oncology, University of Texas Medical Branch, Galveston, Texas (United States)

2011-05-01T23:59:59.000Z

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441

Human metastatic melanoma cell lines express high levels of growth hormone receptor and respond to GH treatment  

SciTech Connect

Highlights: •Most cancer types of the NCI60 have sub-sets of cell lines with high GHR expression. •GHR is highly expressed in melanoma cell lines. •GHR is elevated in advanced stage IV metastatic tumors vs. stage III. •GH treatment of metastatic melanoma cell lines alters growth and cell signaling. -- Abstract: Accumulating evidence implicates the growth hormone receptor (GHR) in carcinogenesis. While multiple studies show evidence for expression of growth hormone (GH) and GHR mRNA in human cancer tissue, there is a lack of quantification and only a few cancer types have been investigated. The National Cancer Institute’s NCI60 panel includes 60 cancer cell lines from nine types of human cancer: breast, CNS, colon, leukemia, melanoma, non-small cell lung, ovarian, prostate and renal. We utilized this panel to quantify expression of GHR, GH, prolactin receptor (PRLR) and prolactin (PRL) mRNA with real-time RT qPCR. Both GHR and PRLR show a broad range of expression within and among most cancer types. Strikingly, GHR expression is nearly 50-fold higher in melanoma than in the panel as a whole. Analysis of human metastatic melanoma biopsies confirmed GHR gene expression in melanoma tissue. In these human biopsies, the level of GHR mRNA is elevated in advanced stage IV tumor samples compared to stage III. Due to the novel finding of high GHR in melanoma, we examined the effect of GH treatment on three NCI60 melanoma lines (MDA-MB-435, UACC-62 and SK-MEL-5). GH increased proliferation in two out of three cell lines tested. Further analysis revealed GH-induced activation of STAT5 and mTOR in a cell line dependent manner. In conclusion, we have identified cell lines and cancer types that are ideal to study the role of GH and PRL in cancer, yet have been largely overlooked. Furthermore, we found that human metastatic melanoma tumors express GHR and cell lines possess active GHRs that can modulate multiple signaling pathways and alter cell proliferation. Based on this data, GH could be a new therapeutic target in melanoma.

Sustarsic, Elahu G. [Edison Biotechnology Institute, 1 Watertower Drive, Athens, OH (United States) [Edison Biotechnology Institute, 1 Watertower Drive, Athens, OH (United States); Department of Biological Sciences, Ohio University, Athens, OH (United States); Junnila, Riia K. [Edison Biotechnology Institute, 1 Watertower Drive, Athens, OH (United States)] [Edison Biotechnology Institute, 1 Watertower Drive, Athens, OH (United States); Kopchick, John J., E-mail: kopchick@ohio.edu [Edison Biotechnology Institute, 1 Watertower Drive, Athens, OH (United States); Department of Biological Sciences, Ohio University, Athens, OH (United States); Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH (United States)

2013-11-08T23:59:59.000Z

442

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Office of Legacy Management (LM)

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443

Structural Health Monitoring for Impact Damage in Composite Structures.  

SciTech Connect

Composite structures are increasing in prevalence throughout the aerospace, wind, defense, and transportation industries, but the many advantages of these materials come with unique challenges, particularly in inspecting and repairing these structures. Because composites of- ten undergo sub-surface damage mechanisms which compromise the structure without a clear visual indication, inspection of these components is critical to safely deploying composite re- placements to traditionally metallic structures. Impact damage to composites presents one of the most signi fi cant challenges because the area which is vulnerable to impact damage is generally large and sometimes very dif fi cult to access. This work seeks to further evolve iden- ti fi cation technology by developing a system which can detect the impact load location and magnitude in real time, while giving an assessment of the con fi dence in that estimate. Fur- thermore, we identify ways by which impact damage could be more effectively identi fi ed by leveraging impact load identi fi cation information to better characterize damage. The impact load identi fi cation algorithm was applied to a commercial scale wind turbine blade, and results show the capability to detect impact magnitude and location using a single accelerometer, re- gardless of sensor location. A technique for better evaluating the uncertainty of the impact estimates was developed by quantifying how well the impact force estimate meets the assump- tions underlying the force estimation technique. This uncertainty quanti fi cation technique was found to reduce the 95% con fi dence interval by more than a factor of two for impact force estimates showing the least uncertainty, and widening the 95% con fi dence interval by a fac- tor of two for the most uncertain force estimates, avoiding the possibility of understating the uncertainty associated with these estimates. Linear vibration based damage detection tech- niques were investigated in the context of structural stiffness reductions and impact damage. A method by which the sensitivity to damage could be increased for simple structures was presented, and the challenges of applying that technique to a more complex structure were identi fi ed. The structural dynamic changes in a weak adhesive bond were investigated, and the results showed promise for identifying weak bonds that show little or no static reduction in stiffness. To address these challenges in identifying highly localized impact damage, the possi- bility of detecting damage through nonlinear dynamic characteristics was also identi fi ed, with a proposed technique which would leverage impact location estimates to enable the detection of impact damage. This nonlinear damage identi fi cation concept was evaluated on a composite panel with a substructure disbond, and the results showed that the nonlinear dynamics at the damage site could be observed without a baseline healthy reference. By further developing impact load identi fi cation technology and combining load and damage estimation techniques into an integrated solution, the challenges associated with impact detection in composite struc- tures can be effectively solved, thereby reducing costs, improving safety, and enhancing the operational readiness and availability of high value assets.

Roach, Dennis P.; Raymond Bond (Purdue); Doug Adams (Purdue)

2014-08-01T23:59:59.000Z