National Library of Energy BETA

Sample records for ad alzheimer disease

  1. New Clues in Predicting Alzheimer's Disease

    ScienceCinema (OSTI)

    Jagust, William

    2013-05-29

    Theres a new clue in the search to identify the harbingers of Alzheimers disease. More info: http://newscenter.lbl.gov/feature-stories/2008/12/16/predict-alzheimers-disease/

  2. Reductions in (/sup 3/H)nicotinic acetylcholine binding in Alzheimer's disease and Parkinson's disease: an autoradiographic study

    SciTech Connect (OSTI)

    Whitehouse, P.J.; Martino, A.M.; Wagster, M.V.; Price, D.L.; Mayeux, R.; Atack, J.R.; Kellar, K.J.

    1988-05-01

    In Alzheimer's disease (AD) and Parkinson's disease (PD), dysfunction in the basal forebrain cholinergic system is accompanied by a consistent loss of presynaptic cholinergic markers in cortex, but changes in cholinergic receptor binding sites are poorly understood. In the present study, we used receptor autoradiography to map the distribution of nicotinic (/sup 3/H)acetylcholine binding sites in cortices of individuals with AD and PD and matched control subjects. In both diseases, a profound loss of nicotinic receptors occurs in all cortical layers, particularly the deepest layers.

  3. Nanoimaging to Prevent and Treat Alzheimerís and Parkinsonís Diseases. Scientific/Technical report

    SciTech Connect (OSTI)

    Yuri L. Lyubchenko, PhD, DSc

    2012-12-20

    This project will develop innovative approaches to characterization of the very early stages of protein aggregation that eventually can be translated to the development of early diagnostic tools and efficient treatments for Alzheimerís, Parkinsonís and Huntingtonís diseases. Funding will be used to acquire nanoimaging technology for nanoscale imaging, manipulation and analysis of biomedical materials to develop treatments that will repair disabled proteins and cure diseases that result from protein malfunction, specifically Alzheimerís and Parkinsonís diseases. Expected outcomes include tests for early diagnosis and therapeutic treatments for these devastating neurological diseases. To elucidate the mechanisms of protein misfolding, we will establish an extensive program of experimental studies using a broad arsenal of advanced nanoscale and traditional techniques that will be integrated with molecular-scale modeling of protein misfolding and the nucleation of aggregate structures. To identify intracellular machinery or/and multicomponent complexes critically involved in protein misfolding, we will characterize interactions between targeted proteins and specific intracellular components or metabolites that impact on protein conformational pathways leading to protein misfolding accompanied by formation of toxic aggregated morphologies. To design innovative nanotechnology tools for the control of intracellular protein misfolding and aggregation processes, we will develop a predictive molecular scale model for intracellular protein misfolding and the formation of toxic aggregates. Verified through experimental studies, the objective is to establish an enabling foundation for the engineering of novel molecular diagnostics and therapeutics for various cellular pathologies.

  4. DEVELOPMENT OF AUTOMATED SOFTWARE PROGRAM FOR THE ANALYSIS OF ALZHEIMER'S DISEASE BETA-AMYLOID SCANS

    SciTech Connect (OSTI)

    Mariotti, Jack; Zubal, George

    2013-12-18

    Study goal: A Phase 1 evaluation of the kinetics, clearance and cerebral distribution of one novel peripheral benzodiazepine receptors(PBR)positron emission tomography (PET) imaging agent, 18F-PBR-111 following intravenous administration in healthy volunteers and Alzheimer's disease (AD) patients. Short title: Evaluation of PET imaging with PBR-111 in HV and AD subjects Proof of Mechanism. Primary Objective: To evaluate the cerebral distribution of PBR-111 positron emission tomography (PET) for detection/exclusion of microglial activation in patients with Alzheimer's disease subjects compared to healthy volunteers. Secondary objectives: - To assess the dynamic uptake and washout of [18F]PBR-111, a potential imaging bio-marker for inflammatory changes in brain, using positron emission tomography in subjects with Alzheimer's disease (AD) and healthy volunteers (HV). - To perform blood metabolite characterization of [18F]PBR-111 in subjects with AD and HV to determine the nature of metabolites in assessment of [18F]-PBR-111 as a PET brain imaging agent. Name of radioactive drug substance: PBR-111 Dose(s): The applied PBR-111 radioactive dose will be up to 5.0 mCi, diluted in a maximum of 10 ml of saline. The radioligand will be administered as a slow intravenous bolus injection (i.e., 6 sec/ml) into a large vein (e.g., antecubital vein). Route of administration: Intravenous injection Duration of treatment: Single administration of a diagnostic agent Indication: PBR-111 positron emission tomography (PET) imaging has the potential to detect microglial activation. In the presence of PBR-111 uptake (representative of microglial activation), inflammation in the brain can be detected. Diagnosis and main criteria for inclusion: Study participants will be HVs and patients diagnosed with probable AD. HVs must be 18 years of age (at least four subjects 50 years of age) and have no evidence of cognitive impairment or other neurologic disease by medical history. The lack of

  5. Metabonomic Profiling of TASTPM Transgenic Alzheimer's Disease Mouse Model

    SciTech Connect (OSTI)

    Hu, Zeping; Browne, Edward R.; Liu, Tao; Angel, Thomas E.; Ho, Paul C.; Chun Yong Chan, Eric

    2012-12-07

    Identification of molecular mechanisms underlying early stage Alzheimer’s disease (AD) is important for the development of new therapies against and diagnosis of AD. In this study, non-targeted metabotyping of TASTPM transgenic AD mice was performed. The metabolic profiles of both brain and plasma of TASTPM mice were characterized using gas chromatography-mass spectrometry and compared to those of wild type C57BL/6J mice. TASTPM mice were metabolically distinct compared to wild type mice (Q28 Y = 0.587 and 0.766 for PLS-DA models derived from brain and plasma, respectively). A number of metabolites were found to be perturbed in TASTPM mice in both brain (D11 fructose, L-valine, L-serine, L-threonine, zymosterol) and plasma (D-glucose, D12 galactose, linoleic acid, arachidonic acid, palmitic acid and D-gluconic acid). In addition, enzyme immunoassay confirmed that selected endogenous steroids were significantly perturbed in brain (androstenedione and 17-OH-progesterone) and plasma (cortisol and testosterone) of TASTPM mice. Ingenuity pathway analysis revealed that perturbations related to amino acid metabolism (brain), steroid biosynthesis (brain), linoleic acid metabolism (plasma) and energy metabolism (plasma) accounted for the differentiation of TASTPM and wild-type

  6. Fourier Transform Infrared Imaging Showing Reduced Unsaturated Lipid Content in the Hippocampus of a mouse Model of Alzheimer's Disease

    SciTech Connect (OSTI)

    Leskovjan, A.C.; Kretlow, A.; Miller, L.M.

    2010-04-01

    Polyunsaturated fatty acids are essential to brain functions such as membrane fluidity, signal transduction, and cell survival. It is also thought that low levels of unsaturated lipid in the brain may contribute to Alzheimer's disease (AD) risk or severity. However, it is not known how accumulation of unsaturated lipids is affected in different regions of the hippocampus, which is a central target of AD plaque pathology, during aging. In this study, we used Fourier transform infrared imaging (FTIRI) to visualize the unsaturated lipid content in specific regions of the hippocampus in the PSAPP mouse model of AD as a function of plaque formation. Specifically, the unsaturated lipid content was imaged using the olefinic {double_bond}CH stretching mode at 3012 cm{sup -1}. The axonal, dendritic, and somatic layers of the hippocampus were examined in the mice at 13, 24, 40, and 56 weeks old. Results showed that lipid unsaturation in the axonal layer was significantly increased with normal aging in control (CNT) mice (p < 0.01) but remained low and relatively constant in PSAPP mice. Thus, these findings indicate that unsaturated lipid content is reduced in hippocampal white matter during amyloid pathogenesis and that maintaining unsaturated lipid content early in the disease may be critical in avoiding progression of the disease.

  7. A State-Wide Research Network for Alzheimer's Disease

    SciTech Connect (OSTI)

    Mintzer, Jacobo E.; Bachman, D. L.; Stuckey, M.; Ebeling, M.; Wagner, M. T.; Evans, W. J.; Hirth, V.; Walker, A.; Joglekar, R.; Faison, W.

    2014-03-13

    The Specific Aim of the proposal was to develop an administrative structure that will facilitate the development of AD research across the state of SC by providing key services such as (but not limited to) seeking funding research opportunities, financial tracking, regulatory management, central recruitment, training for investigators and coordinators, data collection, data storing, and data processing to researchers across the state.

  8. Key residues for the oligomerization of A{beta}42 protein in Alzheimer's disease

    SciTech Connect (OSTI)

    Ngo, Sam; Guo, Zhefeng

    2011-10-28

    Highlights: Black-Right-Pointing-Pointer A{beta} oligomers are neurotoxins and likely the causing agents for Alzheimer's disease. Black-Right-Pointing-Pointer A{beta}42 fusion protein form globular oligomers. Black-Right-Pointing-Pointer A{beta}42 fusion protein oligomers contain SDS-resistant tetramers and hexamers. Black-Right-Pointing-Pointer Cysteine substitutions at residues 31, 32, 34, 39-41 disrupt A{beta}42 oligomerization. -- Abstract: Deposition of amyloid fibrils consisting of amyloid {beta} (A{beta}) protein as senile plaques in the brain is a pathological hallmark of Alzheimer's disease. However, a growing body of evidence shows that soluble A{beta} oligomers correlate better with dementia than fibrils, suggesting that A{beta} oligomers may be the primary toxic species. The structure and oligomerization mechanism of these A{beta} oligomers are crucial for developing effective therapeutics. Here we investigated the oligomerization of A{beta}42 in the context of a fusion protein containing GroES and ubiquitin fused to the N-terminus of A{beta} sequence. The presence of fusion protein partners, in combination with a denaturing buffer containing 8 M urea at pH 10, is unfavorable for A{beta}42 aggregation, thus allowing only the most stable structures to be observed. Transmission electron microscopy showed that A{beta}42 fusion protein formed globular oligomers, which bound weakly to thioflavin T and Congo red. SDS-PAGE shows that A{beta}42 fusion protein formed SDS-resistant hexamers and tetramers. In contrast, A{beta}40 fusion protein remained as monomers on SDS gel, suggesting that the oligomerization of A{beta}42 fusion protein is not due to the fusion protein partners. Cysteine scanning mutagenesis at 22 residue positions further revealed that single cysteine substitutions of the C-terminal hydrophobic residues (I31, I32, L34, V39, V40, and I41) led to disruption of hexamer and tetramer formation, suggesting that hydrophobic interactions between these

  9. OSTIblog Articles in the Alzheimer's Topic | OSTI, US Dept of Energy Office

    Office of Scientific and Technical Information (OSTI)

    of Scientific and Technical Information Alzheimer's Topic Sharing Data Leads to Progress by Nena Moss 19 Aug, 2010 in Personal Perspectives My mother died in March 2010 after a 15-year battle with Alzheimer's, so I pay particular attention to news about this dreadful disease. A recent New York Times article caught my eye: "Sharing of Data Leads to Progress on Alzheimer's." How did sharing data lead to progress on Alzheimer's? A collaborative effort, the Alzheimer's Disease

  10. Noggin and BMP4 co-modulate adult hippocampal neurogenesis in the APP{sub swe}/PS1{sub {Delta}E9} transgenic mouse model of Alzheimer's disease

    SciTech Connect (OSTI)

    Tang, Jun; Song, Min; Wang, Yanyan; Fan, Xiaotang; Xu, Haiwei; Bai, Yun

    2009-07-31

    In addition to the subventricular zone, the dentate gyrus of the hippocampus is one of the few brain regions in which neurogenesis continues into adulthood. Perturbation of neurogenesis can alter hippocampal function, and previous studies have shown that neurogenesis is dysregulated in Alzheimer disease (AD) brain. Bone morphogenetic protein-4 (BMP4) and its antagonist Noggin have been shown to play important roles both in embryonic development and in the adult nervous system, and may regulate hippocampal neurogenesis. Previous data indicated that increased expression of BMP4 mRNA within the dentate gyrus might contribute to decreased hippocampal cell proliferation in the APP{sub swe}/PS1{sub {Delta}E9} mouse AD model. However, it is not known whether the BMP antagonist Noggin contributes to the regulation of neurogenesis. We therefore studied the relative expression levels and localization of BMP4 and its antagonist Noggin in the dentate gyrus and whether these correlated with changes in neurogenesis in 6-12 mo old APP{sub swe}/PS1{sub {Delta}E9} transgenic mice. Bromodeoxyuridine (BrdU) was used to label proliferative cells. We report that decreased neurogenesis in the APP/PS1 transgenic mice was accompanied by increased expression of BMP4 and decreased expression of Noggin at both the mRNA and protein levels; statistical analysis showed that the number of proliferative cells at different ages correlated positively with Noggin expression and negatively with BMP4 expression. Intraventricular administration of a chimeric Noggin/Fc protein was used to block the action of endogenous BMP4; this resulted in a significant increase in the number of BrdU-labeled cells in dentate gyrus subgranular zone and hilus in APP/PS1 mice. These results suggest that BMP4 and Noggin co-modulate neurogenesis.

  11. Comparative mapping of DNA markers from the familial Alzheimer disease and Down syndrome regions of human chromosome 21 to mouse chromosomes 16 and 17

    SciTech Connect (OSTI)

    Cheng, S.V.; Nadeau, J.H.; Tanzi, R.E.; Watkins, P.C.; Jagadesh, J.; Taylor, B.A.; Haines, J.L.; Sacchi, N.; Gusella, J.F. )

    1988-08-01

    Mouse trisomy 16 has been proposed as an animal model of Down syndrome (DS), since this chromosome contains homologues of several loci from the q22 band of human chromosome 21. The recent mapping of the defect causing familial Alzheimer disease (FAD) and the locus encoding the Alzheimer amyloid {beta} precursor protein (APP) to human chromosome 21 has prompted a more detailed examination of the extent of conservation of this linkage group between the two species. Using anonymous DNA probes and cloned genes from human chromosome 21 in a combination of recombinant inbred and interspecific mouse backcross analyses, the authors have established that the linkage group shared by mouse chromosome 16 includes not only the critical DS region of human chromosome 21 but also the APP gene and FAD-linked markers. Extending from the anonymous DNA locus D21S52 to ETS2, the linkage map of six loci spans 39% recombination in man but only 6.4% recombination in the mouse. A break in synteny occurs distal to ETS2, with the homologue of the human marker D21S56 mapping to mouse chromosome 17. Conservation of the linkage relationships of markers in the FAD region suggests that the murine homologue of the FAD locus probably maps to chromosome 16 and that detailed comparison of the corresponding region in both species could facilitate identification of the primary defect in this disorder. The break in synteny between the terminal portion of human chromosome 21 and mouse chromosome 16 indicates, however, that mouse trisomy 16 may not represent a complete model of DS.

  12. Beta-Amyloid Deposition and Alzheimer's Type Changes Induced by Borrelia Spirochetes

    SciTech Connect (OSTI)

    Miklossy,J.; Kis, A.; Radenovic, A.; Miller, L.; Forro, L.; Martins, R.; Reiss, K.; Darbinian, N.; Darekar, P.; et al.

    2006-01-01

    The pathological hallmarks of Alzheimer's disease (AD) consist of {beta}-amyloid plaques and neurofibrillary tangles in affected brain areas. The processes, which drive this host reaction are unknown. To determine whether an analogous host reaction to that occurring in AD could be induced by infectious agents, we exposed mammalian glial and neuronal cells in vitro to Borrelia burgdorferi spirochetes and to the inflammatory bacterial lipopolysaccharide (LPS). Morphological changes analogous to the amyloid deposits of AD brain were observed following 2-8 weeks of exposure to the spirochetes. Increased levels of {beta}-amyloid presursor protein (A{beta}PP) and hyperphosphorylated tau were also detected by Western blots of extracts of cultured cells that had been treated with spirochetes or LPS. These observations indicate that, by exposure to bacteria or to their toxic products, host responses similar in nature to those observed in AD may be induced.

  13. A New F-18 Labeled PET Agent For Imaging Alzheimer's Plaques

    SciTech Connect (OSTI)

    Kulkarni, Padmakar V.; Hao Guiyang; Arora, Veera; Long, Michael; Slavine, Nikolai; Chiguru, Srinivas; Qu Baoxi; Sun Xiankai; Bennett, Michael; Antich, Peter P.; Bonte, Frederick J.; Vasdev, Neil

    2011-06-01

    Amyloid plaques and neurofibrillary tangles are hallmarks of Alzheimer's disease (AD). Advances in development of imaging agents have focused on targeting amyloid plaques. Notable success has been the development of C-11 labeled PIB (Pittsburgh Compound) and a number of studies have demonstrated the utility of this agent. However, the short half life of C-11 (t1/2: 20 min), is a limitation, thus has prompted the development of F-18 labeled agents. Most of these agents are derivatives of amyloid binding dyes; Congo red and Thioflavin. Some of these agents are in clinical trials with encouraging results. We have been exploring new class of agents based on 8-hydroxy quinoline, a weak metal chelator, targeting elevated levels of metals in plaques. Iodine-123 labeled clioquinol showed affinity for amyloid plaques however, it had limited brain uptake and was not successful in imaging in intact animals and humans. We have been successful in synthesizing F-18 labeled 8-hydroxy quinoline. Small animal PET/CT imaging studies with this agent showed high (7-10% ID/g), rapid brain uptake and fast washout of the agent from normal mice brains and delayed washout from transgenic Alzheimer's mice. These promising results encouraged us in further evaluation of this class of compounds for imaging AD plaques.

  14. Multimodal Imaging of Alzheimer Pathophysiology in the Brain's Default Mode Network

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Shin, Jonghan; Kepe, Vladimir; Small, Gary W.; Phelps, Michael E.; Barrio, Jorge R.

    2011-01-01

    The spatial correlations between the brain's default mode network (DMN) and the brain regions known to develop pathophysiology in Alzheimer's disease (AD) have recently attracted much attention. In this paper, we compare results of different functional and structural imaging modalities, including MRI and PET, and highlight different patterns of anomalies observed within the DMN. Multitracer PET imaging in subjects with and without dementia has demonstrated that [C-11]PIB- and [F-18]FDDNP-binding patterns in patients with AD overlap within nodes of the brain's default network including the prefrontal, lateral parietal, lateral temporal, and posterior cingulate cortices, with the exception of the medial temporalmore¬†¬Ľ cortex (especially, the hippocampus) where significant discrepancy between increased [F-18]FDDNP binding and negligible [C-11]PIB-binding was observed. [F-18]FDDNP binding in the medial temporal cortex‚ÄĒa key constituent of the DMN‚ÄĒcoincides with both the presence of amyloid and tau pathology, and also with cortical areas with maximal atrophy as demonstrated by T1-weighted MR imaging of AD patients.¬ę¬†less

  15. OSTIblog Articles in the disease Topic | OSTI, US Dept of Energy Office of

    Office of Scientific and Technical Information (OSTI)

    Scientific and Technical Information disease Topic Sharing Data Leads to Progress by Nena Moss 19 Aug, 2010 in Personal Perspectives My mother died in March 2010 after a 15-year battle with Alzheimer's, so I pay particular attention to news about this dreadful disease. A recent New York Times article caught my eye: "Sharing of Data Leads to Progress on Alzheimer's." How did sharing data lead to progress on Alzheimer's? A collaborative effort, the Alzheimer's Disease Neuroimaging

  16. Ad Lucem Workshop Welcome

    Broader source: Energy.gov [DOE]

    This presentation summarizes the information given by DOE during the DOE Ad Lucem workshop, Feb. 17, 2012.

  17. Retiree AD&D Insurance

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AD&D Insurance Retiree AD&D Insurance AD&D coverage during retirement. Contact Retiree Insurance Providers Accidental death & dismemberment (AD&D) benefits for retirees The AD&D...

  18. Ad Lucem Workshop Welcome

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    I was a sorry witness of such doings, knowing that a little theory and calculation would have saved him ninety per cent of his labor." - Nikola Tesla (1931) Ad Lucem Modeling ...

  19. Fermilab Today - Classified Ad Policy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fermilab Classified Ad Policy Fermilab Today now requires that people placing classified ads must belong to one of these categories: a. active and retired employees of Fermi...

  20. Kaolin AD | Open Energy Information

    Open Energy Info (EERE)

    Kaolin AD Jump to: navigation, search Name: Kaolin AD Place: Senovo, Bulgaria Zip: 7038 Sector: Solar Product: Kaolin is Europe's fourth largest producer of silica sands and owns a...

  1. Ad Hoc Meetings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Ad Hoc Meetings Ad Hoc Meetings Ad Hoc Meetings 43.pdf (44.36 KB) More Documents & Publications Radio and Spectrum Management ICAM Workshop PKI Workshop

  2. Fermilab Today | Classifieds Ad Form

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    will be posted on the Internet and can lead to responses from outside the lab. Some ads posted in Fermilab Today in the past have received responses from scammers who, for...

  3. Gravitational charges of transverse asymptotically AdS spacetimes

    SciTech Connect (OSTI)

    Cebeci, Hakan; Sarioglu, Oezguer; Tekin, Bayram

    2006-12-15

    Using Killing-Yano symmetries, we construct conserved charges of spacetimes that asymptotically approach to the flat or anti-de Sitter spaces only in certain directions. In D dimensions, this allows one to define gravitational charges (such as mass and angular momenta densities) of p-dimensional branes/solitons or any other extended objects that curve the transverse space into an asymptotically flat or AdS one. Our construction answers the question of what kind of charges the antisymmetric Killing-Yano tensors lead to.

  4. A State-Wide Research Network for Alzheimer's Disease (Technical...

    Office of Scientific and Technical Information (OSTI)

    Contributing Orgs: MUSC & Ralph H. Johnson VAMC, Charleston, SC Senior Primary Care, Columbia, SC Comprehensive Neurological Services, Florence, SC Hospital Medicine Consultants, ...

  5. Systematics of Coupling Flows in AdS Backgrounds

    SciTech Connect (OSTI)

    Goldberger, Walter D.; Rothstein, Ira Z.

    2003-03-18

    We give an effective field theory derivation, based on the running of Planck brane gauge correlators, of the large logarithms that arise in the predictions for low energy gauge couplings in compactified AdS}_5 backgrounds, including the one-loop effects of bulk scalars, fermions, and gauge bosons. In contrast to the case of charged scalars coupled to Abelian gauge fields that has been considered previously in the literature, the one-loop corrections are not dominated by a single 4D Kaluza-Klein mode. Nevertheless, in the case of gauge field loops, the amplitudes can be reorganized into a leading logarithmic contribution that is identical to the running in 4D non-Abelian gauge theory, and a term which is not logarithmically enhanced and is analogous to a two-loop effect in 4D. In a warped GUT model broken by the Higgs mechanism in the bulk,we show that the matching scale that appears in the large logarithms induced by the non-Abelian gauge fields is m_{XY}^2/k where m_{XY} is the bulk mass of the XY bosons and k is the AdS curvature. This is in contrast to the UV scale in the logarithmic contributions of scalars, which is simply the bulk mass m. Our results are summarized in a set of simple rules that can be applied to compute the leading logarithmic predictions for coupling constant relations within a given warped GUT model. We present results for both bulk Higgs and boundary breaking of the GUT gauge

  6. The Ad Lucem Research Network

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    The Ad Lucem Research Network Lada Adamic Associate Professor, School of Information & Center for the Study of Complex Systems University of Michigan Research interests: structure and dynamics of social and information networks, with a particular emphasis on information diffusion, expertise sharing, and online communities D. Lazer et al. "Computational Social Science." Science 323, 5915 (2009). J. Leskovec, L. A. Adamic, and B. A. Huberman. "The dynamics of viral

  7. OSTIblog Articles in the Alzheimer's Topic | OSTI, US Dept of...

    Office of Scientific and Technical Information (OSTI)

    John Q. Trojanowski, an Alzheimer's researcher at the University of Pennsylvania, "It's not science the way most of us have practiced it in our careers. But we all realized that we ...

  8. Doppler Lidar Wind Value-Added Product

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    8 Doppler Lidar Wind Value-Added Product RK Newsom C Sivaraman TR Shippert LD Riihimaki ... DOESC-ARMTR-148 Doppler Lidar Wind Value-Added Product Version 1.0 RK Newsom C Sivaraman ...

  9. Ad Lucem: Modeling Market Transformation Pathways Workshop

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AD LUCEM ... TOWARD THE LIGHT! 1 Ad Lucem: Modeling Market Transformation Pathways Workshop Berkeley, California | Friday, February 17, 2012 Ad lucem - Latin for toward the light - captures the essence of the SunShot Initiative. We seek to accelerate the global transition to clean, abundant solar energy by expanding our understanding of the technology-society-economics nexus. The ability to control energy resources is the enabler for growth, development, and opportunity. The diffusion of

  10. Ad-Venta | Open Energy Information

    Open Energy Info (EERE)

    190 alle de Bourgogne Place: Bourg de Page Country: France Zip: 26300 Sector: Hydrogen Product: Hydrogen storage (on board) Year Founded: 2006 Website: www.ad-venta.com...

  11. Transportation Plan Ad Hoc Working Group | Department of Energy

    Office of Environmental Management (EM)

    Plan Ad Hoc Working Group Transportation Plan Ad Hoc Working Group PDF icon Transportation Plan Ad Hoc Working Group More Documents & Publications Nuclear Fuel Storage and...

  12. Stability of HoŇôava-Lifshitz black holes in the context of AdS...

    Office of Scientific and Technical Information (OSTI)

    Stability of Hoava-Lifshitz black holes in the context of AdSCFT Citation Details In-Document Search Title: Stability of Hoava-Lifshitz black holes in the context of AdSCFT ...

  13. Reveal for Adding OpenMP

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Reveal for Adding OpenMP Reveal for Adding OpenMP Reveal is an integrated performance analysis and code optimization tool. Reveal provides: Source code navigation using the analysis data of the entire program Performance data collected during program execution Dependency information for targeted loops Helps users in optimizing code by providing variable scoping feedback and suggested compiler directives For information on how to use Cray Reveal and how to use it on NERSC systems, refer to the

  14. ARM - Value-Added Product Status Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Status Reports Publications Journal Articles Conference Documents Program Documents & Technical Reports Publications Database Public Information Materials Image Library Videos Publication Resources Submit a Publication Publishing Procedures ARM Style Guide (PDF, 448KB) Acronyms Glossary Logos Contacts RSS for Publications Value-Added Product Status Reports ARM Climate Research Facility Quarterly Value-Added Product Report July 1-September 30, 2015 (PDF, 1MB) ARM Climate Research Facility

  15. QCD Condensates and Holographic Wilson Loops for Asymptotically AdS Spaces

    SciTech Connect (OSTI)

    Quevedo, R. Carcasses; Goity, Jose L.; Trinchero, Roberto C.

    2014-02-01

    The minimization of the Nambu-Goto (NG) action for a surface whose contour defines a circular Wilson loop of radius a placed at a finite value of the coordinate orthogonal to the border is considered. This is done for asymptotically AdS spaces. The condensates of dimension n = 2, 4, 6, 8, and 10 are calculated in terms of the coefficients in the expansion in powers of the radius a of the on-shell subtracted NG action for small a->0. The subtraction employed is such that it presents no conflict with conformal invariance in the AdS case and need not introduce an additional infrared scale for the case of confining geometries. It is shown that the UV value of the gluon condensates is universal in the sense that it only depends on the first coefficients of the difference with the AdS case.

  16. ARM Climate Research Facility Quarterly Value-Added Product Report...

    Office of Scientific and Technical Information (OSTI)

    Program Document: ARM Climate Research Facility Quarterly Value-Added Product Report Citation Details In-Document Search Title: ARM Climate Research Facility Quarterly Value-Added ...

  17. ARM Climate Research Facility Quarterly Value-Added Product Report...

    Office of Scientific and Technical Information (OSTI)

    ARM Climate Research Facility Quarterly Value-Added Product Report Citation Details In-Document Search Title: ARM Climate Research Facility Quarterly Value-Added Product Report ...

  18. ARM Climate Research Facility Quarterly Value-Added Product Report...

    Office of Scientific and Technical Information (OSTI)

    Technical Report: ARM Climate Research Facility Quarterly Value-Added Product Report Citation Details In-Document Search Title: ARM Climate Research Facility Quarterly Value-Added ...

  19. Ad Lucem: Modeling of Market Transformation Pathways Workshop...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Ad Lucem: Modeling of Market Transformation Pathways Workshop Agenda This document details the agenda for the DOE Ad Lucem: Modeling of Market Transformation Pathways Workshop on ...

  20. Building America Expert Meeting: Key Innovations for Adding Energy...

    Energy Savers [EERE]

    Key Innovations for Adding Energy Efficiency to Maintenance Projects Building America Expert Meeting: Key Innovations for Adding Energy Efficiency to Maintenance Projects This ...

  1. Shuchi Energy Ad Promotions P Ltd | Open Energy Information

    Open Energy Info (EERE)

    Shuchi Energy Ad Promotions P Ltd Jump to: navigation, search Name: Shuchi Energy Ad Promotions (P) Ltd Place: Hyderabad, Andhra Pradesh, India Zip: 500062 Sector: Solar Product:...

  2. The Ad Lucem Research Network | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ...lucem2012attendees.pdf More Documents & Publications Big Data Projects on Solar Tech Evolution and Diffusion Ad Lucem Workshop Welcome Ad Lucem Workshop: Modeling Breakout Session

  3. Addendum Added to Innovative Demonstration of Geothermal Energy...

    Energy Savers [EERE]

    Addendum Added to Innovative Demonstration of Geothermal Energy Production FOA Addendum Added to Innovative Demonstration of Geothermal Energy Production FOA July 2, 2010 - 2:13pm ...

  4. Supporting Dynamic Ad hoc Collaboration Capabilities

    SciTech Connect (OSTI)

    Agarwal, Deborah A.; Berket, Karlo

    2003-07-14

    Modern HENP experiments such as CMS and Atlas involve as many as 2000 collaborators around the world. Collaborations this large will be unable to meet often enough to support working closely together. Many of the tools currently available for collaboration focus on heavy-weight applications such as videoconferencing tools. While these are important, there is a more basic need for tools that support connecting physicists to work together on an ad hoc or continuous basis. Tools that support the day-to-day connectivity and underlying needs of a group of collaborators are important for providing light-weight, non-intrusive, and flexible ways to work collaboratively. Some example tools include messaging, file-sharing, and shared plot viewers. An important component of the environment is a scalable underlying communication framework. In this paper we will describe our current progress on building a dynamic and ad hoc collaboration environment and our vision for its evolution into a HENP collaboration environment.

  5. ARM KAZR-ARSCL Value Added Product

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Jensen, Michael

    The Ka-band ARM Zenith Radars (KAZRs) have replaced the long-serving Millimeter Cloud Radars, or MMCRs. Accordingly, the primary MMCR Value Added Product (VAP), the Active Remote Sensing of CLouds (ARSCL) product, is being replaced by a KAZR-based version, the KAZR-ARSCL VAP. KAZR-ARSCL provides cloud boundaries and best-estimate time-height fields of radar moments.

  6. ARM KAZR-ARSCL Value Added Product

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Jensen, Michael

    2012-09-28

    The Ka-band ARM Zenith Radars (KAZRs) have replaced the long-serving Millimeter Cloud Radars, or MMCRs. Accordingly, the primary MMCR Value Added Product (VAP), the Active Remote Sensing of CLouds (ARSCL) product, is being replaced by a KAZR-based version, the KAZR-ARSCL VAP. KAZR-ARSCL provides cloud boundaries and best-estimate time-height fields of radar moments.

  7. Merged Sounding Value-Added Product

    SciTech Connect (OSTI)

    Troyan, D

    2010-03-03

    The Merged Sounding value-added product (VAP) uses a combination of observations from radiosonde soundings, the microwave radiometer (MWR), surface meteorological instruments, and European Centre for Medium-Range Weather Forecasts (ECMWF) model output with a sophisticated scaling/interpolation/smoothing scheme in order to define profiles of the atmospheric thermodynamic state at one-minute temporal intervals and a total of 266 altitude levels.

  8. ARM - Value-Added Product (VAP) Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (VAP) Reports Publications Journal Articles Conference Documents Program Documents & Technical Reports Publications Database Public Information Materials Image Library Videos Publication Resources Submit a Publication Publishing Procedures ARM Style Guide (PDF, 448KB) Acronyms Glossary Logos Contacts RSS for Publications Value-Added Product (VAP) Reports For proper viewing, technical reports should be viewed with Adobe Acrobat Reader. Download the latest version from the Adobe Reader

  9. ARM - Value-Added Products - Status

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    - Status Report Expand Orange | Expand Blue | Expand Green | Collapse All See Legend for Data Availability explanation. ARM - Value-Added Products - Status Last Update: March 21 2016 19:00:50 +/- Vap Name Translator Developer Frequency Tier Producer Data Availability ACRED (ARM Cloud Retrieval Ensemble Data) Shaocheng Xie Chuanfeng Zhao, Renata Mc Coy Periodically Evaluation Developer ARM Overview: Developer Description: The ARM Cloud Retrieval Ensemble Dataset (ACRED) is a multi-year cloud

  10. Association between environmental exposure to pesticides and neurodegenerative diseases

    SciTech Connect (OSTI)

    Parron, Tesifon; Requena, Mar; Hernandez, Antonio F.; Alarcon, Raquel

    2011-11-15

    Preliminary studies have shown associations between chronic pesticide exposure in occupational settings and neurological disorders. However, data on the effects of long-term non-occupational exposures are too sparse to allow any conclusions. This study examines the influence of environmental pesticide exposure on a number of neuropsychiatric conditions and discusses their underlying pathologic mechanisms. An ecological study was conducted using averaged prevalence rates of Alzheimer's disease, Parkinson's disease, multiple sclerosis, cerebral degeneration, polyneuropathies, affective psychosis and suicide attempts in selected Andalusian health districts categorized into areas of high and low environmental pesticide exposure based on the number of hectares devoted to intensive agriculture and pesticide sales per capita. A total of 17,429 cases were collected from computerized hospital records (minimum dataset) between 1998 and 2005. Prevalence rates and the risk of having Alzheimer's disease, Parkinson's disease, multiple sclerosis and suicide were significantly higher in districts with greater pesticide use as compared to those with lower pesticide use. The multivariate analyses showed that the population living in areas with high pesticide use had an increased risk for Alzheimer's disease and suicide attempts and that males living in these areas had increased risks for polyneuropathies, affective disorders and suicide attempts. In conclusion, this study supports and extends previous findings and provides an indication that environmental exposure to pesticides may affect the human health by increasing the incidence of certain neurological disorders at the level of the general population. -- Highlights: Black-Right-Pointing-Pointer Environmental exposure to pesticides and neurodegenerative-psychiatric disorders. Black-Right-Pointing-Pointer Increased risk for Alzheimer's disease and suicide attempts in high exposure areas. Black-Right-Pointing-Pointer Males from

  11. Entropy of near-extremal black holes in AdS5

    SciTech Connect (OSTI)

    Simon, Joan; Balasubramanian, Vijay; de Boer, Jan; Jejjala, Vishnu; Simon, Joan

    2007-07-24

    We construct the microstates of near-extremal black holes in AdS_5 x S5 as gases of defects distributed in heavy BPS operators in the dual SU(N) Yang-Mills theory. These defects describe open strings on spherical D3-branes in the S5, and we show that they dominate the entropy by directly enumerating them and comparing the results with a partition sum calculation. We display new decoupling limits in which the field theory of the lightest open strings on the D-branes becomes dual to a near-horizon region of the black hole geometry. In the single-charge black hole we find evidence for an infrared duality between SU(N) Yang-Mills theories that exchanges the rank of the gauge group with an R-charge. In the two-charge case (where pairs of branes intersect on a line), the decoupled geometry includes an AdS_3 factor with a two-dimensional CFT dual. The degeneracy in this CFT accounts for the black hole entropy. In the three-charge case (where triples of branes intersect at a point), the decoupled geometry contains an AdS_2 factor. Below a certain critical mass, the two-charge system displays solutions with naked timelike singularities even though they do not violate a BPS bound. We suggest a string theoretic resolution of these singularities.

  12. Interpolated Sounding Value-Added Product

    SciTech Connect (OSTI)

    Troyan, D

    2013-04-01

    The Interpolated Sounding (INTERPSONDE) value-added product (VAP) uses a combination of observations from radiosonde soundings, the microwave radiometer (MWR), and surface meteorological instruments in order to define profiles of the atmospheric thermodynamic state at one-minute temporal intervals and a total of at least 266 altitude levels. This VAP is part of the Merged Sounding (MERGESONDE) suite of VAPs. INTERPSONDE is the profile of the atmospheric thermodynamic state created using the algorithms of MERGESONDE without including the model data from the European Centre for Medium-range Weather Forecasting (ECMWF). More specifically, INTERPSONDE VAP represents an intermediate step within the larger MERGESONDE process.

  13. Ad Lucem: Modeling of Market Transformation Pathways Workshop Agenda |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy of Market Transformation Pathways Workshop Agenda Ad Lucem: Modeling of Market Transformation Pathways Workshop Agenda This document details the agenda for the DOE Ad Lucem: Modeling of Market Transformation Pathways Workshop on Feb. 17, 2012. adlucem2012_agenda.pdf (295.01 KB) More Documents & Publications Ad Lucem Workshop Welcome Ad Lucem: Modeling Market Transformation Pathways Workshop The Ad Lucem Research Network

  14. Adding Insulation to an Existing Home | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Weatherize ¬Ľ Insulation ¬Ľ Adding Insulation to an Existing Home Adding Insulation to an Existing Home Adding insulation in an existing home saves money and improves comfort. | Photo courtesy of Dennis Schroeder, NREL. Adding insulation in an existing home saves money and improves comfort. | Photo courtesy of Dennis Schroeder, NREL. Unless your home was specially constructed for energy efficiency, you can probably reduce your energy bills by adding more insulation. Many older homes have less

  15. POSSIBLE CHROMOSPHERIC ACTIVITY CYCLES IN AD LEO

    SciTech Connect (OSTI)

    Buccino, Andrea P.; Petrucci, Romina; Mauas, Pablo J. D.; Jofrť, Emiliano

    2014-01-20

    AD Leo (GJ†388) is an active dM3 flare star that has been extensively observed both in the quiescent and flaring states. Since this active star is near the fully convective boundary, studying its long-term chromospheric activity in detail could be an appreciable contribution to dynamo theory. Here, using the Lomb-Scargle periodogram, we analyze the Ca II†K line-core fluxes derived from CASLEO spectra obtained between 2001 and 2013 and the V magnitude from the ASAS database between 2004 and 2010. From both of these totally independent time series, we obtain a possible activity cycle with a period of approximately seven years and a less significant shorter cycle of approximately two years. A tentative interpretation is that a dynamo operating near the surface could be generating the longer cycle, while a second dynamo operating in the deep convection zone could be responsible for the shorter one. Based on the long duration of our observing program at CASLEO and the fact that we observe different spectral features simultaneously, we also analyze the relation between simultaneous measurements of the Na I index (R{sub D}{sup ?}), H?, and Ca II†K fluxes at different activity levels of AD Leo, including flares.

  16. Quantum compositeness of gravity: black holes, AdS and inflation

    SciTech Connect (OSTI)

    Dvali, Gia; Gomez, Cesar E-mail: cesar.gomez@uam.es

    2014-01-01

    Gravitational backgrounds, such as black holes, AdS, de Sitter and inflationary universes, should be viewed as composite of N soft constituent gravitons. It then follows that such systems are close to quantum criticality of graviton Bose-gas to Bose-liquid transition. Generic properties of the ordinary metric description, including geodesic motion or particle-creation in the background metric, emerge as the large-N limit of quantum scattering of constituent longitudinal gravitons. We show that this picture correctly accounts for physics of large and small black holes in AdS, as well as reproduces well-known inflationary predictions for cosmological parameters. However, it anticipates new effects not captured by the standard semi-classical treatment. In particular, we predict observable corrections that are sensitive to the inflationary history way beyond last 60 e-foldings. We derive an absolute upper bound on the number of e-foldings, beyond which neither de Sitter nor inflationary Universe can be approximated by a semi-classical metric. However, they could in principle persist in a new type of quantum eternity state. We discuss implications of this phenomenon for the cosmological constant problem.

  17. Quantum compositeness of gravity: black holes, AdS and inflation

    SciTech Connect (OSTI)

    Dvali, Gia; Gomez, Cesar

    2014-01-14

    Gravitational backgrounds, such as black holes, AdS, de Sitter and inflationary universes, should be viewed as composite of N soft constituent gravitons. It then follows that such systems are close to quantum criticality of graviton Bose-gas to Bose-liquid transition. Generic properties of the ordinary metric description, including geodesic motion or particle-creation in the background metric, emerge as the large-N limit of quantum scattering of constituent longitudinal gravitons. We show that this picture correctly accounts for physics of large and small black holes in AdS, as well as reproduces well-known inflationary predictions for cosmological parameters. However, it anticipates new effects not captured by the standard semi-classical treatment. In particular, we predict observable corrections that are sensitive to the inflationary history way beyond last 60 e-foldings. We derive an absolute upper bound on the number of e-foldings, beyond which neither de Sitter nor inflationary Universe can be approximated by a semi-classical metric. However, they could in principle persist in a new type of quantum eternity state. We discuss implications of this phenomenon for the cosmological constant problem.

  18. AD Hydro Power Ltd ADHPL | Open Energy Information

    Open Energy Info (EERE)

    AD Hydro Power Ltd ADHPL Jump to: navigation, search Name: AD Hydro Power Ltd. (ADHPL) Place: Noida, Uttar Pradesh, India Zip: 201301 Sector: Hydro Product: Noida-based small hydro...

  19. Ad Lucem Workshop: Modeling Breakout Session | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Workshop: Modeling Breakout Session Ad Lucem Workshop: Modeling Breakout Session This presentation summarizes the information discussed during the modeling breakout session of the DOE Ad Lucem Workshop on Feb. 17, 2012. adlucem2012_modeling_breakout.pdf (1.66 MB) More Documents & Publications Ad Lucem: Modeling of Market Transformation Pathways Workshop Agenda Ad Lucem: Modeling Market Transformation Pathways Workshop Break-out Discussion i: Modeling Consumer Behavior Residential S

  20. Ad Lucem: Modeling Market Transformation Pathways Workshop | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Market Transformation Pathways Workshop Ad Lucem: Modeling Market Transformation Pathways Workshop This white paper summarizes the information discussed during the Ad Lucem: Modeling Market Transformation Pathways Workshop, Feb. 17, 2012, in Berkeley, California. adlucem2012_whitepaper.pdf (547.71 KB) More Documents & Publications Ad Lucem: Modeling of Market Transformation Pathways Workshop Agenda Ad Lucem Workshop Welcome Materials from 2014 SunShot Summit BREAKOUT SESSION: THE

  1. Ads-tec GmbH | Open Energy Information

    Open Energy Info (EERE)

    Raiffeisenstrasse 14 Place: Leinfelden Echterdingen Zip: 70771 Sector: Services Product: Energy Storage Systems Number of Employees: 51-200 Website: www.ads-tec.de Coordinates:...

  2. Recently Added or Revised "Slice" Information (contracts/slice...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Product Recently Added or Revised Information (updated November 2, 2011) Applicable Interest Rates for Slice Product (updated November 2, 2011) Slice Product Review Meeting...

  3. ARM Climate Research Facility Quarterly Value-Added Product Report...

    Office of Scientific and Technical Information (OSTI)

    Climate Research Facility Quarterly Value-Added Product Report Fourth Quarter: July 1-September 30, 2012 Citation Details In-Document Search Title: ARM Climate Research Facility ...

  4. Adding Insulation to an Existing Home | Department of Energy

    Office of Environmental Management (EM)

    existing home saves money and improves comfort. | Photo courtesy of Dennis Schroeder, NREL. Adding insulation in an existing home saves money and improves comfort. | Photo...

  5. DOE Announces Webinars on Adding Solar to Your Building Portfolio...

    Office of Environmental Management (EM)

    DOE Announces Webinars on Adding Solar to Your Building ... from adopting the latest energy efficiency and renewable ... January 28: How to Utilize the National Geothermal Data ...

  6. ARM Climate Research Facility Quarterly Value-Added Product Report

    SciTech Connect (OSTI)

    Sivaraman, Chitra

    2014-11-21

    The purpose of this report is to provide a concise status update for value-added products (VAP) implemented by the Atmospheric Radiation Measurement (ARM) Climate Research Facility.

  7. Bioenergy Demonstration Project: Value-Added Products from Renewable...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Bioenergy Demonstration Project: Value-Added Products from Renewable Fuels May 23, 2013 Technology Area Review: Biochemical Conversion Paul Blum University of Nebraska 2 Goal ...

  8. Doppler Lidar Vertical Velocity Statistics Value-Added Product

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    49 Doppler Lidar Vertical Velocity Statistics Value-Added Product RK Newsom C Sivaraman TR Shippert LD Riihimaki July 2015 DISCLAIMER This report was prepared as an account of work...

  9. Added Public Promotional Page! | OpenEI Community

    Open Energy Info (EERE)

    Added Public Promotional Page Home > Groups > Linked Open Data Workshop in Washington, D.C. Jweers's picture Submitted by Jweers(88) Contributor 27 September, 2012 - 18:10 Event...

  10. Adding Nanocavities to Catalyst Surfaces Enhances Chemical Selectivity...

    Office of Science (SC) Website

    made by adding a template during the atomic layer deposition process that is used to ... Publications C. P. Canlas, J. Lu, N. A. Ray, N. A. Grosso-Giordano, J. W. Elam, S. Lee, R. ...

  11. Value-added agriculture offers small agribusinesses additional income

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    potential Value-added agriculture Community Connections: Your link to news and opportunities from Los Alamos National Laboratory Latest Issue: September 1, 2016 all issues All Issues ¬Ľ submit Value-added agriculture offers small agribusinesses additional income potential Closing the gap between raw product and end user September 1, 2015 Las Nueve Ni√Īas Winery wine label. Las Nueve Ni√Īas Winery wine label. Contact Community Programs Director Kathy Keith Email Editor Ute Haker Email Instead

  12. Anaerobic Digestion (AD): not only methane | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Anaerobic Digestion (AD): not only methane Anaerobic Digestion (AD): not only methane Breakout Session 1: New Developments and Hot Topics Session 1-C: Beyond Biofuels Larry Baresi, Professor of Biology, California State University, Northridge b13_baresi_1-C.pdf (980.78 KB) More Documents & Publications Electrobiocommodities from Carbon Dioxide: Enhancing Microbial Electrosynthesis with Synthetic Electromicrobiology and System Design Hydrogen, Hydrocarbons, and Bioproduct Precursors from

  13. Comments on Cosmic Censorship in AdS/CFT

    SciTech Connect (OSTI)

    Hubeny, Veronika E.; Liu, Xiao; Rangamani, Mukund; Shenker, Stephen

    2004-03-21

    Recently Hertog, Horowitz, and Maeda (HHM) (hep-th/0310054) have proposed that cosmic censorship can be violated in the AdS/CFT context. They argue that for certain initial data there is insufficient energy available to make a black hole whose horizon is big enough to cloak the singularity that forms. We have investigated this proposal in the models HHM discuss and have thus far been unable to find initial data that provably satisfy this criterion, despite our development of an improved lower bound on the size of the singular region. This is consistent with recent numerical results (hep-th/0402109). For certain initial data, the energies of our configurations are not far above the lower bound on the requisite black hole mass, and so it is possible that in the exact time development naked singularities do form. We go on to argue that the finite radius cut-off AdS_5 situation discussed by HHM displays instabilities when the full 10D theory is considered. We propose an AdS_3 example that may well be free of this instability.

  14. Comments on Cosmic Censorship in AdS/CFT

    SciTech Connect (OSTI)

    Hubeny, V.

    2004-04-06

    Recently Hertog, Horowitz, and Maeda (HHM) (hep-th/0310054) have proposed that cosmic censorship can be violated in the AdS/CFT context. They argue that for certain initial data there is insufficient energy available to make a black hole whose horizon is big enough to cloak the singularity that forms. We have investigated this proposal in the models HHM discuss and have thus far been unable to find initial data that provably satisfy this criterion, despite our development of an improved lower bound on the size of the singular region. This is consistent with recent numerical results (hep-th/0402109). For certain initial data, the energies of our configurations are not far above the lower bound on the requisite black hole mass, and so it is possible that in the exact time development naked singularities do form. We go on to argue that the finite radius cut-off AdS5 situation discussed by HHM displays instabilities when the full 10D theory is considered. We propose an AdS3 example that may well be free of this instability.

  15. No-carrier-added [1.sup.11 c]putrescine

    DOE Patents [OSTI]

    McPherson, Daniel W.; Fowler, Joanna S.; Wolf, Alfred P.

    1989-01-01

    The invention relates to a new radiolabeled imaging agent, no-carrier-added [1-.sup.11 C]putrescine, and to the use of this very pure material as a radiotracer with positron emission tomography for imaging brain tumors. The invention further relates to the synthesis of no-carrier-added [1-.sup.11 C]putrescine based on the Michael addition of potassium .sup.11 C-labeled cyanide to acrylonitrile followed by reduction of the .sup.11 C-labeled dinitrile. The new method is rapid and efficient and provides radiotracer with a specific activity greater than 1.4 curies per millimol and in a purity greater than 95%.

  16. Raman Lidar Profiles‚ÄďTemperature (RLPROFTEMP) Value-Added Product

    SciTech Connect (OSTI)

    Newsom, RK; Sivaraman, C; McFarlane, SA

    2012-10-31

    The purpose of this document is to describe the Raman Lidar Profiles‚ÄďTemperature (RLPROFTEMP) value-added product (VAP) and the procedures used to derive atmospheric temperature profiles from the raw RL measurements. Sections 2 and 4 describe the input and output variables, respectively. Section 3 discusses the theory behind the measurement and the details of the algorithm, including calibration and overlap correction.

  17. Doppler Lidar Wind Value-Added Product (Technical Report) | SciTech...

    Office of Scientific and Technical Information (OSTI)

    Wind Value-Added Product Citation Details In-Document Search Title: Doppler Lidar Wind Value-Added Product Wind speed and direction, together with pressure, temperature, and ...

  18. Top Value-Added Chemicals from Biomass - Volume II¬ĄResults of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Value-Added Chemicals from Biomass - Volume IIResults of Screening for Potential Candidates from Biorefinery Lignin Top Value-Added Chemicals from Biomass - Volume IIResults of ...

  19. Neutron Instruments Added at Oak Ridge (Journal Article) | SciTech...

    Office of Scientific and Technical Information (OSTI)

    Neutron Instruments Added at Oak Ridge Citation Details In-Document Search Title: Neutron Instruments Added at Oak Ridge The neutron scattering facilities at Oak Ridge National ...

  20. Evaluation of the Ad Council/DOE "What's Your Excuse" Public...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Ad CouncilDOE "What's Your Excuse" Public Service Advertising Campaign Evaluation of the Ad CouncilDOE "What's Your Excuse" Public Service Advertising Campaign Evaluation of the ...

  1. New Atmospheric Profiling Instrument Added to SGP CART Suite

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3 New Atmospheric Profiling Instrument Added to SGP CART Suite A new atmospheric profiling instrument at the SGP CART site is giving researchers an additional useful data stream. The new instrument is a microwave radiometer profiler (MWRP) developed by Radiometrics Corporation. One ARM Program focus is improving the quality of simulations by global climate models, particularly models that deal with interactions between sunlight (solar radiation) and clouds. To support this improvement, ARM needs

  2. ARM Climate Research Facility Quarterly Value-Added Product Report

    SciTech Connect (OSTI)

    Sivaraman, Chitra

    2013-07-31

    The purpose of this report is to provide a concise status update for value-added products (VAP) implemented by the Atmospheric Radiation Measurement Climate Research Facility. The report is divided into the following sections: (1) new VAPs for which development has begun, (2) progress on existing VAPs, (3) future VAPs that have been recently approved, (4) other work that leads to a VAP, and (5) top requested VAPs from the archive.

  3. Organic Aerosol Component (OACOMP) Value-Added Product Report

    SciTech Connect (OSTI)

    Fast, J; Zhang, Q; Tilp, A; Shippert, T; Parworth, C; Mei, F

    2013-08-23

    Significantly improved returns in their aerosol chemistry data can be achieved via the development of a value-added product (VAP) of deriving OA components, called Organic Aerosol Components (OACOMP). OACOMP is primarily based on multivariate analysis of the measured organic mass spectral matrix. The key outputs of OACOMP are the concentration time series and the mass spectra of OA factors that are associated with distinct sources, formation and evolution processes, and physicochemical properties.

  4. Linear Fresnel Technology added to System Advisor Model's Capabilities -

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    News Releases | NREL Linear Fresnel Technology added to System Advisor Model's Capabilities Now utilities can get detailed information on siting, performance and finances February 8, 2012 A promising Concentrating Solar Power (CSP) technology that uses a stationary receiver tube and an array of mirrors mounted near the ground can now be accessed within the System Advisor Model (SAM), which predicts annual energy production, hourly performance and return on investment. The U.S. Department of

  5. 2D Gridded Surface Data Value-Added Product

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2 2D Gridded Surface Data Value-Added Product Q Tang S Xie July 2015 DISCLAIMER This report was prepared as an account of work sponsored by the U.S. Government. Neither the United States nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned

  6. A Natural Language for AdS/CFT Correlators

    SciTech Connect (OSTI)

    Fitzpatrick, A.Liam; Kaplan, Jared; Penedones, Joao; Raju, Suvrat; van Rees, Balt C.; /YITP, Stony Brook

    2012-02-14

    We provide dramatic evidence that 'Mellin space' is the natural home for correlation functions in CFTs with weakly coupled bulk duals. In Mellin space, CFT correlators have poles corresponding to an OPE decomposition into 'left' and 'right' sub-correlators, in direct analogy with the factorization channels of scattering amplitudes. In the regime where these correlators can be computed by tree level Witten diagrams in AdS, we derive an explicit formula for the residues of Mellin amplitudes at the corresponding factorization poles, and we use the conformal Casimir to show that these amplitudes obey algebraic finite difference equations. By analyzing the recursive structure of our factorization formula we obtain simple diagrammatic rules for the construction of Mellin amplitudes corresponding to tree-level Witten diagrams in any bulk scalar theory. We prove the diagrammatic rules using our finite difference equations. Finally, we show that our factorization formula and our diagrammatic rules morph into the flat space S-Matrix of the bulk theory, reproducing the usual Feynman rules, when we take the flat space limit of AdS/CFT. Throughout we emphasize a deep analogy with the properties of flat space scattering amplitudes in momentum space, which suggests that the Mellin amplitude may provide a holographic definition of the flat space S-Matrix.

  7. Process and targets for production of no-carrier-added radiotin

    DOE Patents [OSTI]

    Srivastava, Suresh C; Zhuikov, Boris Leonidovich; Ermolaev, Stanislav Victorovich; Konyakhin, Nikolay Alexandrovich; Kokhanyuk, Vladimir Mikhailovich; Khamyanov, Stepan Vladimirovich; Togaeva, Natalya Roaldovna

    2014-04-22

    One embodiment of the present invention includes a process for production and recovery of no-carrier-added radioactive tin (NCA radiotin). An antimony target can be irradiated with a beam of accelerated particles forming NCA radiotin, followed by separation of the NCA radiotin from the irradiated target. The target is metallic Sb in a hermetically sealed shell. The shell can be graphite, molybdenum, or stainless steel. The irradiated target can be removed from the shell by chemical or mechanical means, and dissolved in an acidic solution. Sb can be removed from the dissolved irradiated target by extraction. NCA radiotin can be separated from the remaining Sb and other impurities using chromatography on silica gel sorbent. NCA tin-117m can be obtained from this process. NCA tin-117m can be used for labeling organic compounds and biological objects to be applied in medicine for imaging and therapy of various diseases.

  8. Some engineering properties of heavy concrete added silica fume

    SciTech Connect (OSTI)

    Akka?, Ay?e; Ba?yi?it, Celalettin; Esen, Serap

    2013-12-16

    Many different types of building materials have been used in building construction for years. Heavy concretes can be used as a building material for critical building as it can contain a mixture of many heavy elements. The barite itself for radiation shielding can be used and also in concrete to produce the workable concrete with a maximum density and adequate structural strength. In this study, some engineering properties like compressive strength, elasticity modules and flexure strength of heavy concretesí added Silica fume have been investigated.

  9. Vocational Rehabilitation -Value Added: Explaining What We Do,

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Vocational Rehabilitation -Value Added: Explaining What We Do, Craig Bock, MA, CRC Washington State IARP Quarterly Newsletter - June 2009 If you have an injury at work, do you know what happens next or how you would navigate the Workers' Compensation system should you need to? What does RCW 51.32.095 (state law) and WAC 296-19A-070 (administrative rules) mean to you? If you could not return to your job and had permanent physical or cognitive restrictions who would help you explore your return to

  10. Commercial Demonstration of Wood Recovery, Recycling, and Value Adding Technologies

    SciTech Connect (OSTI)

    Auburn Machinery, Inc.

    2004-07-15

    This commercial demonstration project demonstrated the technical feasibility of converting low-value, underutilized and waste stream solid wood fiber material into higher valued products. With a growing need to increase product/production yield and reduce waste in most sawmills, few recovery operations and practically no data existed to support the viability of recovery operations. Prior to our efforts, most all in the forest products industry believed that recovery was difficult, extremely labor intensive, not cost effective, and that recovered products had low value and were difficult to sell. This project provided an opportunity for many within the industry to see through demonstration that converting waste stream material into higher valued products does in fact offer a solution. Our work, supported by the U.S. Department of Energy, throughout the project aimed to demonstrate a reasonable approach to reducing the millions of recoverable solid wood fiber tons that are annually treated as and converted into low value chips, mulch and fuel. Consequently sawmills continue to suffer from reduced availability of forest resources, higher raw material costs, growing waste disposal problems, increased global competition, and more pressure to operate in an Environmentally Friendly manner. It is our belief (based upon the experience of this project) that the successful mainstreaming of the recovery concept would assist in alleviating this burden as well as provide for a realistically achievable economic benefit to those who would seriously pursue the concept and tap into the rapidly growing ''GREEN'' building marketplace. Ultimately, with participation and aggressive pursuit of the recovery concept, the public would benefit in that: (1) Landfill/disposal waste volume could be reduced adding greater life to existing municipal landfill sites thereby minimizing the need to prematurely license and open added facilities. Also, there would be a cost avoidance benefit associated

  11. 2D Gridded Surface Data Value-Added Product

    SciTech Connect (OSTI)

    Tang, Q; Xie, S

    2015-08-30

    This report describes the Atmospheric Radiation Measurement (ARM) Best Estimate (ARMBE) 2-dimensional (2D) gridded surface data (ARMBE2DGRID) value-added product. Spatial variability is critically important to many scientific studies, especially those that involve processes of great spatial variations at high temporal frequency (e.g., precipitation, clouds, radiation, etc.). High-density ARM sites deployed at the Southern Great Plains (SGP) allow us to observe the spatial patterns of variables of scientific interests. The upcoming megasite at SGP with its enhanced spatial density will facilitate the studies at even finer scales. Currently, however, data are reported only at individual site locations at different time resolutions for different datastreams. It is difficult for users to locate all the data they need and requires extra effort to synchronize the data. To address these problems, the ARMBE2DGRID value-added product merges key surface measurements at the ARM SGP sites and interpolates the data to a regular 2D grid to facilitate the data application.

  12. Adding kinetics and hydrodynamics to the CHEETAH thermochemical code

    SciTech Connect (OSTI)

    Fried, L.E., Howard, W.M., Souers, P.C.

    1997-01-15

    In FY96 we released CHEETAH 1.40, which made extensive improvements on the stability and user friendliness of the code. CHEETAH now has over 175 users in government, academia, and industry. Efforts have also been focused on adding new advanced features to CHEETAH 2.0, which is scheduled for release in FY97. We have added a new chemical kinetics capability to CHEETAH. In the past, CHEETAH assumed complete thermodynamic equilibrium and independence of time. The addition of a chemical kinetic framework will allow for modeling of time-dependent phenomena, such as partial combustion and detonation in composite explosives with large reaction zones. We have implemented a Wood-Kirkwood detonation framework in CHEETAH, which allows for the treatment of nonideal detonations and explosive failure. A second major effort in the project this year has been linking CHEETAH to hydrodynamic codes to yield an improved HE product equation of state. We have linked CHEETAH to 1- and 2-D hydrodynamic codes, and have compared the code to experimental data. 15 refs., 13 figs., 1 tab.

  13. Matching the Hagedorn temperature in AdS/CFT correspondence

    SciTech Connect (OSTI)

    Harmark, Troels; Orselli, Marta

    2006-12-15

    We match the Hagedorn/deconfinement temperature of planar N=4 super Yang-Mills (SYM) on RxS{sup 3} to the Hagedorn temperature of string theory on AdS{sub 5}xS{sup 5}. The match is done in a near-critical region where both gauge theory and string theory are weakly coupled. The near-critical region is near a point with zero temperature and critical chemical potential. On the gauge-theory side we are taking a decoupling limit found in Ref. 7 in which the physics of planar N=4 SYM is given exactly by the ferromagnetic XXX{sub 1/2} Heisenberg spin chain. We find moreover a general relation between the Hagedorn/deconfinement temperature and the thermodynamics of the Heisenberg spin chain and we use this to compute it in two distinct regimes. On the string-theory side, we identify the dual limit for which the string tension and string coupling go to zero. This limit is taken of string theory on a maximally supersymmetric pp-wave background with a flat direction, obtained from a Penrose limit of AdS{sub 5}xS{sup 5}. We compute the Hagedorn temperature of the string theory and find agreement with the Hagedorn/deconfinement temperature computed on the gauge-theory side.

  14. Zero added oxygen for high quality sputtered ITO. A data science investigation of reduced Sn-content and added Zr

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Peshek, Timothy J.; Burst, James M.; Coutts, Timothy J.; Gessert, Timothy A.

    2016-01-19

    Here, we demonstrate mobilities of >45 cm2/V s for sputtered tin-doped indium oxide (ITO) films at zero added oxygen. All films were deposited with 5 wt. % SnO2, instead of the more conventional 8‚Äď10 wt. %, and had varying ZrO2 content from 0 to 3 wt. %, with a subsequent reduction in In2O3 content. Moreover, these films were deposited by radio-frequency magnetron sputtering from nominally stoichiometric targets with varying oxygen partial pressure in the sputter ambient. Anomalous behavior was discovered for films with no Zr-added, where a bimodality of high and low mobilities was discovered for nominally similar growth conditions.more¬†¬Ľ However, all films showed the lowest resistivity and highest mobilities when the oxygen partial pressure in the sputter ambient was zero. This result is contrasted with several other reports of ITO transport performance having a maximum for small but nonzero oxygen partial pressure. Our result is attributed to the reduced concentration of SnO2. The addition of ZrO2 yielded the highest mobilities at >55 cm2/V s and the films showed a modest increase in optical transmission with increasing Zr-content.¬ę¬†less

  15. Perfect fluidity of a dissipative system: Analytical solution for the Boltzmann equation in AdS2 ‚ďć S2

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Noronha, Jorge; Denicol, Gabriel S.

    2015-12-30

    In this paper we obtain an analytical solution of the relativistic Boltzmann equation under the relaxation time approximation that describes the out-of-equilibrium dynamics of a radially expanding massless gas. This solution is found by mapping this expanding system in flat spacetime to a static flow in the curved spacetime AdS2 ‚ďć S2. We further derive explicit analytic expressions for the momentum dependence of the single-particle distribution function as well as for the spatial dependence of its moments. We find that this dissipative system has the ability to flow as a perfect fluid even though its entropy density does not matchmore¬†¬Ľ the equilibrium form. The nonequilibrium contribution to the entropy density is shown to be due to higher-order scalar moments (which possess no hydrodynamical interpretation) of the Boltzmann equation that can remain out of equilibrium but do not couple to the energy-momentum tensor of the system. Furthermore, in this system the slowly moving hydrodynamic degrees of freedom can exhibit true perfect fluidity while being totally decoupled from the fast moving, nonhydrodynamical microscopic degrees of freedom that lead to entropy production.¬ę¬†less

  16. Stabilization of lead lithium iron tungstate with adding barium titanate

    SciTech Connect (OSTI)

    Lu, C.; Fang, B.

    1997-01-01

    The kinetics of formation, phase stabilities, and dielectric constants of Pb(Li{sub 1/4}Fe{sub 1/4}W{sub 1/2})O{sub 3} and BaTiO{sub 3}-added Pb(Li{sub 1/4}Fe{sub 1/4}W{sub 1/2})O{sub 3} have been compared. The addition of 2 mol{percent} BaTiO{sub 3} in Pb(Li{sub 1/4}Fe{sub 1/4}W{sub 1/2})O{sub 3} was confirmed to promote the complete formation of the perovskite phase at 700{degree}C. Also the thermal stability of the perovskite phase was significantly enhanced, which results in an increase of the dielectric permittivity. {copyright} {ital 1997 Materials Research Society.}

  17. Station-based Surface Data Value-Added Product

    SciTech Connect (OSTI)

    Tang, Q.; Xie, S.

    2015-07-01

    This report describes the Atmospheric Radiation Measurement (ARM) Best Estimate (ARMBE) station-based surface data (ARMBESTNS) value-added product. It is a twin data product of the ARMBE 2-Dimensional gridded (ARMBE2DGRID) data set. Unlike the ARMBE2DGRID data set, ARMBESTNS data are reported at the original site locations and show the original information (except for the interpolation over time). Therefore, the users have the flexibility to process the data with the approach more suitable for their applications. This document provides information about the input data, quality control (QC) method, and output format of this data set. As much of the information is identical to that of the ARMBE2DGRID data, this document will emphasize more on the different aspects of these two data sets.

  18. No-carrier-added (/sup 18/F)-N-methylspiroperidol

    DOE Patents [OSTI]

    Shiue, C.Y.; Fowler, J.S.; Wolf, A.P.

    1985-10-04

    The present invention is directed to the synthesis of a radioligand, labeled with a positron emitting radionuclide which is suitable for dynamic studies in humans using positron emission transaxial tomography. No-carrier-added (NCA) (/sup 18/F)-N-methylspiroperiodl is prepared from four different sustrates: p-nitrobenzonitrile, cyclopropyl p-nitrophenyl ketone, p-cyclopropanoyl-N,N,N-trimethylanilinium iodide and p-cyclopropanoyl-N,N,N-trimethylanilinium perchlorate. The process for the production of NCA (/sup 18/F)-N-methylspiroperidol is a nucleophilic aromatic substitution reaction. Furthermore, the compound of this invention is shown to be effective as a new drug of choice for in vivo examination of dopamine binding sites in a human brain. In particular, this drug is primarily useful in the noninvasive technique of positron emission transaxial tomography (PETT).

  19. Doppler Lidar Vertical Velocity Statistics Value-Added Product

    SciTech Connect (OSTI)

    Newsom, R. K.; Sivaraman, C.; Shippert, T. R.; Riihimaki, L. D.

    2015-07-01

    Accurate height-resolved measurements of higher-order statistical moments of vertical velocity fluctuations are crucial for improved understanding of turbulent mixing and diffusion, convective initiation, and cloud life cycles. The Atmospheric Radiation Measurement (ARM) Climate Research Facility operates coherent Doppler lidar systems at several sites around the globe. These instruments provide measurements of clear-air vertical velocity profiles in the lower troposphere with a nominal temporal resolution of 1 sec and height resolution of 30 m. The purpose of the Doppler lidar vertical velocity statistics (DLWSTATS) value-added product (VAP) is to produce height- and time-resolved estimates of vertical velocity variance, skewness, and kurtosis from these raw measurements. The VAP also produces estimates of cloud properties, including cloud-base height (CBH), cloud frequency, cloud-base vertical velocity, and cloud-base updraft fraction.

  20. Sonde Adjust Value-Added Product Technical Report

    SciTech Connect (OSTI)

    Troyan, D

    2012-01-09

    The Sonde Adjust (SONDEADJUST) value-added product (VAP) creates a file that includes all fields from original Atmospheric Radiation Measurement Climate Research Facility (ARM Facility) radiosonde files and contains several value-added fields that provide adjustments related to well-known humidity issues. SONDEADJUST produces data that correct documented biases in radiosonde humidity measurements. Previous efforts towards applying some of these corrections are available via the discontinued PI product sgpsondecorr1miloC1. Unique fields contained within this datastream include smoothed original relative humidity, dry bias corrected relative humidity, and final corrected relative humidity. The smoothed RH field refines the relative humidity from integers-the resolution of the instrument-to fractions of a percent. This profile is then used to calculate the dry bias corrected field. The final correction fixes the time-lag problem and uses the dry-bias field as input into the algorithm. In addition to dry bias, solar heating is another correction that is encompassed in the final corrected RH field. Output from SONDEADJUST differs from the previous RH-corrected datastreams in important ways. First, all three types of ARM radiosondes-Vaisala RS-80, RS-90, and RS-92-are corrected using dedicated procedures and/or parameters. Second, the output variables include all of those found in the original radiosonde file: dry bulb temperature, dewpoint temperature, wind speed, wind direction, eastward wind component, northward wind component, wind status (a Vaisala-produced field used in conjunction with the Loran system), ascent rate, and original relative humidity. Additional humidity fields are smoothed relative humidity, dry biased corrected relative humidity, final ambient relative humidity, and scaled adjusted relative humidity. Third, quality control (QC) flags of the fields from the original radiosonde datastream are brought into the SONDEADJUST output file. Additional QC

  1. Aerosol Optical Depth Value-Added Product for the SAS-He Instrument...

    Office of Scientific and Technical Information (OSTI)

    Aerosol Optical Depth Value-Added Product for the SAS-He Instrument Citation Details In-Document Search Title: Aerosol Optical Depth Value-Added Product for the SAS-He Instrument ...

  2. Top Value Added Chemicals from Biomass: Volume I--Results of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Value Added Chemicals from Biomass: Volume I--Results of Screening for Potential Candidates from Sugars and Synthesis Gas Top Value Added Chemicals from Biomass: Volume I--Results ...

  3. Differential Network Analyses of Alzheimer’s Disease Identify Early Events in Alzheimer’s Disease Pathology

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Xia, Jing; Rocke, David M.; Perry, George; Ray, Monika

    2014-01-01

    In late-onset Alzheimer‚Äôs disease (AD), multiple brain regions are not affected simultaneously. Comparing the gene expression of the affected regions to identify the differences in the biological processes perturbed can lead to greater insight into AD pathogenesis and early characteristics. We identified differentially expressed (DE) genes from single cell microarray data of four AD affected brain regions: entorhinal cortex (EC), hippocampus (HIP), posterior cingulate cortex (PCC), and middle temporal gyrus (MTG). We organized the DE genes in the four brain regions into region-specific gene coexpression networks. Differential neighborhood analyses in the coexpression networks were performed to identify genes with lowmore¬†¬Ľ topological overlap (TO) of their direct neighbors. The low TO genes were used to characterize the biological differences between two regions. Our analyses show that increased oxidative stress, along with alterations in lipid metabolism in neurons, may be some of the very early events occurring in AD pathology. Cellular defense mechanisms try to intervene but fail, finally resulting in AD pathology as the disease progresses. Furthermore, disease annotation of the low TO genes in two independent protein interaction networks has resulted in association between cancer, diabetes, renal diseases, and cardiovascular diseases.¬ę¬†less

  4. Prototype indicators of value added through public involvement

    SciTech Connect (OSTI)

    Lach, D.; Hixson, P.; Ramonas, L.

    1995-12-01

    As more managers realize that public input in public sector decision making is a given in the current political and social climate, many are turning to public involvement as a way to manage input so that it is beneficial to their decisions and projects. Public involvement is starting to become a familiar way of doing business for many Federal agencies and its contractors. Yet, many, if not most agency and contractor managers are still unclear about the value and costs that public involvement adds to their projects. Proponents claim that public involvement increases the acceptability of project goals by increasing stakeholders` knowledge about and involvement in decisions of importance to them. In spite of these assertions avowing the benefits of public involvement, proponents have not generated methods that demonstrate or provide evidence of such value added through incorporating public involvement into projects. As these questions about the value and costs of public involvement efforts increase, there is a pressing need to document the value and costs of public involvement for the participants in these processes--the stakeholders--and to present this information to decision makers in ways that help them assess the value and costs of managing public input through a public involvement program.

  5. No-carrier-added (18F)-N-methylspiroperidol

    DOE Patents [OSTI]

    Shiue, Chyng-Yann; Fowler, Joanna S.; Wolf, Alfred P.

    1993-07-06

    There is disclosed a radioligand labeled with a positron emitting radionuclide suitable for dynamic study in living humans with positron emission transaxial tomography. [.sup.18 F]-N-methylspiroperidol, exhibiting extremely high affinity for the dopamine receptors, provides enhanced uptake and retention in the brain concomitant with reduced radiation burden. These characteristics all combine to provide [.sup.18 F]-N-methylspiroperidol as a radioligand superior to known radioligands for mapping dopamine receptors in normal and disease states in the living brain. Additionally, a new synthetic procedure for this material is disclosed.

  6. No-carrier-added (18F)-N-methylspiroperidol

    DOE Patents [OSTI]

    Shiue, Chyng-Yann; Fowler, Joanna S.; Wolf, Alfred P.

    1993-01-01

    There is disclosed a radioligand labeled with a positron emitting radionuclide suitable for dynamic study in living humans with positron emission transaxial tomography. [.sup.18 F]-N-methylspiroperidol, exhibiting extremely high affinity for the dopamine receptors, provides enhanced uptake and retention in the brain concomitant with reduced radiation burden. These characteristics all combine to provide [.sup.18 F]-N-methylspiroperidol as a radioligand superior to known radioligands for mapping dopamine receptors in normal and disease states in the living brain. Additionally, a new synthetic procedure for this material is disclosed.

  7. Beryllium disease

    SciTech Connect (OSTI)

    Not Available

    1991-12-20

    After two workers at the nuclear weapons plant at Oak Ridge National Laboratory in Tennessee were diagnosed earlier this year with chronic beryllium disease (CBD), a rare and sometimes fatal scarring of the lungs, the Department of Energy ordered up a 4-year probe. Now, part of that probe has begun - tests conducted by the Oak Ridge Associated Universities' Center for Epidemiological Research measuring beryllium sensitivity in 3,000 people who've been exposed to the metal's dust since Manhattan Project managers opened the Y-12 plant at Oak Ridge in 1943. Currently, 119 Y-12 employees process beryllium, which has a number of industrial uses, including rocket heat shields and nuclear weapon and electrical components. The disease often takes 20 to 25 years to develop, and the stricken employees haven't worked with beryllium for years. There is no cure for CBD, estimated to strike 2% of people exposed to the metal. Anti-inflammatory steroids alleviate such symptoms as a dry cough, weight loss, and fatigue. Like other lung-fibrosis diseases that are linked to lung cancer, some people suspect CBD might cause some lung cancer. While difficult to diagnose, about 900 cases of CBD have been reported since a Beryllium Case Registry was established in 1952. The Department of Energy (DOE) estimates that about 10,000 DOE employees and 800,000 people in private industry have worked with beryllium.

  8. Exact solutions with AdS asymptotics of Einstein and Einstein-Maxwell gravity minimally coupled to a scalar field

    SciTech Connect (OSTI)

    Cadoni, Mariano; Serra, Matteo; Mignemi, Salvatore

    2011-10-15

    We propose a general method for solving exactly the static field equations of Einstein and Einstein-Maxwell gravity minimally coupled to a scalar field. Our method starts from an ansatz for the scalar field profile, and determines, together with the metric functions, the corresponding form of the scalar self-interaction potential. Using this method we prove a new no-hair theorem about the existence of hairy black-hole and black-brane solutions and derive broad classes of static solutions with radial symmetry of the theory, which may play an important role in applications of the AdS/CFT correspondence to condensed matter and strongly coupled QFTs. These solutions include: (1) four- or generic (d+2)-dimensional solutions with planar, spherical or hyperbolic horizon topology; (2) solutions with anti-de Sitter, domain wall and Lifshitz asymptotics; (3) solutions interpolating between an anti-de Sitter spacetime in the asymptotic region and a domain wall or conformal Lifshitz spacetime in the near-horizon region.

  9. No-carrier-added [.sup.18 F]-N-fluoroalkylspiroperidols

    DOE Patents [OSTI]

    Shiue, Chyng-Yann; Wolf, Alfred P.; Bai, Lan-Qin; Teng, Ren-Tui

    1989-01-01

    There is disclosed radioligands labeled with the position emitting radionuclide [.sup.18 F] suitable for dynamic study in living humans with position emission transaxial tomography. These new [.sup.18 F]-N-fluoroalkylspiroperidols, wherein the alkyl group contains from 2-6 carbon atoms, exhibit extremely high affinity for the dopamine receptors and provide enhanced uptake and retention in the brain concomitant with reduced radiation burden. These characteristics all combine to make these new radioligands useful for mapping dopamine receptors in normal and disease states in the living brain. Additionally, a new synthetic procedure for these radioligands as well as a new procedure for preparing the radiolabeled alkyl halide alkylating reagents are also disclosed.

  10. Minimal unitary representation of 5d superconformal algebra F(4) and AdS6/CFT5 higher spin (super)-algebras

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Fernando, Sudarshan; GŁnaydin, Murat

    2014-11-28

    We study the minimal unitary representation (minrep) of SO(5, 2), obtained by quantization of its geometric quasiconformal action, its deformations and supersymmetric extensions. The minrep of SO(5, 2) describes a massless conformal scalar field in five dimensions and admits a unique ďdeformationĒ which describes a massless conformal spinor. Scalar and spinor minreps of SO(5, 2) are the 5d analogs of Diracís singletons of SO(3, 2). We then construct the minimal unitary representation of the unique 5d supercon-formal algebra F(4) with the even subalgebra SO(5, 2) ◊SU(2). The minrep of F(4) describes a massless conformal supermultiplet consisting of two scalar andmore†Ľone spinor fields. We then extend our results to the construction of higher spin AdS6/CFT5 (super)-algebras. The Joseph ideal of the minrep of SO(5, 2) vanishes identically as operators and hence its enveloping algebra yields the AdS6/CFT5 bosonic higher spin algebra directly. The enveloping algebra of the spinor minrep defines a ďdeformedĒ higher spin algebra for which a deformed Joseph ideal vanishes identically as operators. These results are then extended to the construction of the unique higher spin AdS6/CFT5 superalgebra as the enveloping algebra of the minimal unitary realization of F(4) obtained by the quasiconformal methods.ę†less

  11. MWRRET Value-Added Product: The Retrieval of Liquid Water Path...

    Office of Scientific and Technical Information (OSTI)

    MWRRET Value-Added Product: The Retrieval of Liquid Water Path and Precipitable Water Vapor from Microwave Radiometer (MWR) Data Sets (Revision 2) Citation Details In-Document ...

  12. MWRRET Value-Added Product: The Retrieval of Liquid Water Path...

    Office of Scientific and Technical Information (OSTI)

    public from the National Technical Information Service, Springfield, VA at www.ntis.gov. ... microwave radiometer (MWR) Retrieval (MWRRET) value-added product (VAP) algorithm. ...

  13. Evaluation of the Ad Council/DOE "What's Your Excuse" Public Service

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Advertising Campaign | Department of Energy Ad Council/DOE "What's Your Excuse" Public Service Advertising Campaign Evaluation of the Ad Council/DOE "What's Your Excuse" Public Service Advertising Campaign Evaluation of the Ad Council/DOE "What's Your Excuse" Public Service Advertising Campaign, June 2010, a document prepared for the U.S. Department of Energy's Office of Energy Efficiency and Renewable Energy. Ad Council Campaign Evaluation (1.88 MB) More

  14. Methods for chemical recovery of non-carrier-added radioactive tin from irradiated intermetallic Ti-Sb targets

    DOE Patents [OSTI]

    Lapshina, Elena V.; Zhuikov, Boris L.; Srivastava, Suresh C.; Ermolaev, Stanislav V.; Togaeva, Natalia R.

    2012-01-17

    The invention provides a method of chemical recovery of no-carrier-added radioactive tin (NCA radiotin) from intermetallide TiSb irradiated with accelerated charged particles. An irradiated sample of TiSb can be dissolved in acidic solutions. Antimony can be removed from the solution by extraction with dibutyl ether. Titanium in the form of peroxide can be separated from tin using chromatography on strong anion-exchange resin. In another embodiment NCA radiotin can be separated from iodide solution containing titanium by extraction with benzene, toluene or chloroform. NCA radiotin can be finally purified from the remaining antimony and other impurities using chromatography on silica gel. NCA tin-117m can be obtained from this process. NCA tin-117m can be used for labeling organic compounds and biological objects to be applied in medicine for imaging and therapy of various diseases.

  15. ADS genes for reducing saturated fatty acid levels in seed oils

    DOE Patents [OSTI]

    Heilmann, Ingo H; Shanklin, John

    2014-03-18

    The present invention relates to enzymes involved in lipid metabolism. In particular, the present invention provides coding sequences for Arabidopsis Desaturases (ADS), the encoded ADS polypeptides, and methods for using the sequences and encoded polypeptides, where such methods include decreasing and increasing saturated fatty acid content in plant seed oils.

  16. ADS genes for reducing saturated fatty acid levels in seed oils

    DOE Patents [OSTI]

    Heilmann, Ingo H.; Shanklin, John

    2010-02-02

    The present invention relates to enzymes involved in lipid metabolism. In particular, the present invention provides coding sequences for Arabidopsis Desaturases (ADS), the encoded ADS polypeptides, and methods for using the sequences and encoded polypeptides, where such methods include decreasing and increasing saturated fatty acid content in plant seed oils.

  17. High resolution A/D conversion based on piecewise conversion at lower resolution

    DOE Patents [OSTI]

    Terwilliger, Steve

    2012-06-05

    Piecewise conversion of an analog input signal is performed utilizing a plurality of relatively lower bit resolution A/D conversions. The results of this piecewise conversion are interpreted to achieve a relatively higher bit resolution A/D conversion without sampling frequency penalty.

  18. Scattering Amplitudes, the AdS/CFT Correspondence, Minimal Surfaces, and Integrability

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Alday, Luis F.

    2010-01-01

    We focus on the computation of scattering amplitudes of planar maximally supersymmetric Yang-Mill in four dimensions at strong coupling by means of the AdS/CFT correspondence and explain how the problem boils down to the computation of minimal surfaces in AdS in the first part of this paper. In the second part of this review we explain how integrability allows to give a solution to the problem in terms of a set of integral equations. The intention of the review is to give a pedagogical, rather than very detailed, exposition.

  19. CYBERSECURITY AND USER ACCOUNTABILITY IN THE C-AD CONTROL SYSTEM

    SciTech Connect (OSTI)

    MORRIS,J.T.; BINELLO, S.; D OTTAVIO, T.; KATZ, R.A.

    2007-10-15

    A heightened awareness of cybersecurity has led to a review of the procedures that ensure user accountability for actions performed on the computers of the Collider-Accelerator Department (C-AD) Control System. Control system consoles are shared by multiple users in control rooms throughout the C-AD complex. A significant challenge has been the establishment of procedures that securely control and monitor access to these shared consoles without impeding accelerator operations. This paper provides an overview of C-AD cybersecurity strategies with an emphasis on recent enhancements in user authentication and tracking methods.

  20. EIA Energy Efficiency-Table 3d. Value Added by Selected Industries...

    Gasoline and Diesel Fuel Update (EIA)

    d Page Last Modified: May 2010 Table 3d. Value Added1 by Selected Industries, 1998, 2002, and 2006 (Current Brillion Dollars) MECS Survey Years NAICS Subsector and Industry 1998...

  1. EIA Energy Efficiency-Table 4d. Value Added by Selected Industries...

    Gasoline and Diesel Fuel Update (EIA)

    d Page Last Modified: May 2010 Table 4d. Value Added1 by Selected Industries, 1998, 2002, and 2006 (Billion 2000 Dollars 2) MECS Survey Years NAICS Subsector and Industry 1998 2002...

  2. Toward the AdS/CFT gravity dual for high energy collisions. II...

    Office of Scientific and Technical Information (OSTI)

    II. The stress tensor on the boundary Citation Details In-Document Search Title: Toward the AdSCFT gravity dual for high energy collisions. II. The stress tensor on the boundary ...

  3. DOE/SC-ARM/TR-100 Raman Lidar Profiles Best Estimate Value-Added...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    0 Raman Lidar Profiles Best Estimate Value-Added Product Technical Report R Newsom January 2012 DISCLAIMER This report was prepared as an account of work sponsored by the U.S. ...

  4. Role of paraoxonase 1 (PON1) in organophosphate metabolism: Implications in neurodegenerative diseases

    SciTech Connect (OSTI)

    Androutsopoulos, Vasilis P.; Kanavouras, Konstantinos; Tsatsakis, Aristidis M.

    2011-11-15

    Organophosphate pesticides are a class of compounds that are widely used in agricultural and rural areas. Paraoxonase 1 (PON1) is a phase-I enzyme that is involved in the hydrolysis of organophosphate esters. Environmental poisoning by organophosphate compounds has been the main driving force of previous research on PON1 enzymes. Recent discoveries in animal models have revealed the important role of the enzyme in lipid metabolism. However although PON1 function is well established in experimental models, the contribution of PON1 in neurodegenerative diseases remains unclear. In this minireview we summarize the involvement of PON1 genotypes in the occurrence of Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis. A brief overview of latest epidemiological studies, regarding the two most important PON1 coding region polymorphisms PON1-L55M and PON1-Q192R is presented. Positive and negative associations of PON1 with disease occurrence are reported. Notably the MM and RR alleles contribute a risk enhancing effect for the development of some neurodegenerative diseases, which may be explained by the reduced lipoprotein free radical scavenging activity that may give rise to neuronal damage, through distinct mechanism. Conflicting findings that fail to support this postulate may represent the human population ethnic heterogeneity, different sample size and environmental parameters affecting PON1 status. We conclude that further epidemiological studies are required in order to address the exact contribution of PON1 genome in combination with organophosphate exposure in populations with neurodegenerative diseases.

  5. AdS/QCD and Applications of Light-Front Holography

    SciTech Connect (OSTI)

    Brodsky, Stanley J.; Cao, Fu-Guang; de Teramond, Guy F.; /Costa Rica U.

    2012-02-16

    Light-Front Holography leads to a rigorous connection between hadronic amplitudes in a higher dimensional anti-de Sitter (AdS) space and frame-independent light-front wavefunctions of hadrons in 3 + 1 physical space-time, thus providing a compelling physical interpretation of the AdS/CFT correspondence principle and AdS/QCD, a useful framework which describes the correspondence between theories in a modified AdS5 background and confining field theories in physical space-time. To a first semiclassical approximation, where quantum loops and quark masses are not included, this approach leads to a single-variable light-front Schroedinger equation which determines the eigenspectrum and the light-front wavefunctions of hadrons for general spin and orbital angular momentum. The coordinate z in AdS space is uniquely identified with a Lorentz-invariant coordinate {zeta} which measures the separation of the constituents within a hadron at equal light-front time. The internal structure of hadrons is explicitly introduced and the angular momentum of the constituents plays a key role. We give an overview of the light-front holographic approach to strongly coupled QCD. In particular, we study the photon-to-meson transition form factors (TFFs) F{sub M{gamma}}(Q{sup 2}) for {gamma}{gamma}* {yields} M using light-front holographic methods. The results for the TFFs for the {eta} and {eta}' mesons are also presented. Some novel features of QCD are discussed, including the consequences of confinement for quark and gluon condensates. A method for computing the hadronization of quark and gluon jets at the amplitude level is outlined.

  6. Expert Meeting Report: Key Innovations for Adding Energy Efficiency to Maintenance Projects

    SciTech Connect (OSTI)

    Wood, A.; Wiehagen, J.

    2012-09-01

    This report describes an expert meeting hosted by the Building America research team NAHB Research Center, which was held on February 8, 2012, in Orlando, Florida. The topic, Key Innovations for Adding Energy Efficiency to Maintenance Projects, was intended to provide direction to more focused efforts to increase the efficiency of existing homes; in this meeting, the focus was specifically for re-roofing and the opportunities for adding energy efficiency upgrades during this major home repair activity.

  7. Top Value Added Chemicals from Biomass: Volume I--Results of Screening for

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Potential Candidates from Sugars and Synthesis Gas | Department of Energy Value Added Chemicals from Biomass: Volume I--Results of Screening for Potential Candidates from Sugars and Synthesis Gas Top Value Added Chemicals from Biomass: Volume I--Results of Screening for Potential Candidates from Sugars and Synthesis Gas This report identifies twelve building block chemicals that can be produced from sugars via biological or chemical conversions. 35523.pdf (1.41 MB) More Documents &

  8. Top Value-Added Chemicals from Biomass - Volume II¬ĄResults of Screening

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    for Potential Candidates from Biorefinery Lignin | Department of Energy Value-Added Chemicals from Biomass - Volume II¬ĄResults of Screening for Potential Candidates from Biorefinery Lignin Top Value-Added Chemicals from Biomass - Volume II¬ĄResults of Screening for Potential Candidates from Biorefinery Lignin This report evaluates lignin¬źs role as a renewable raw material resource. pnnl-16983.pdf (1006.18 KB) More Documents & Publications Low Cost Carbon Fiber from Renewable Resources

  9. Building America Expert Meeting: Key Innovations for Adding Energy Efficiency to Maintenance Projects

    Office of Energy Efficiency and Renewable Energy (EERE)

    This report describes an expert meeting hosted by the Building America research team NAHB Research Center, which was held on February 8, 2012, in Orlando, Florida. The topic, Key Innovations for Adding Energy Efficiency to Maintenance Projects, was intended to provide direction to more focused efforts to increase the efficiency of existing homes; in this meeting, the focus was specifically for re-roofing and the opportunities for adding energy efficiency upgrades during this major home repair activity.

  10. DOE Announces Webinars on Adding Solar to Your Building Portfolio, How to

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Use DOE's Newest Facilities, and More | Department of Energy Adding Solar to Your Building Portfolio, How to Use DOE's Newest Facilities, and More DOE Announces Webinars on Adding Solar to Your Building Portfolio, How to Use DOE's Newest Facilities, and More February 27, 2014 - 4:48pm Addthis EERE offers webinars to the public on a range of subjects, from adopting the latest energy efficiency and renewable energy technologies to training for the clean energy workforce. Webinars are free;

  11. Nonasymptotically AdS/dS solutions and their higher dimensional origins

    SciTech Connect (OSTI)

    Cai Ronggen; Wang Anzhong

    2004-10-15

    We look for and analyze in some details some exact solutions of Einstein-Maxwell-dilaton gravity with one or two Liouville-type dilaton potential(s) in an arbitrary dimension. Such a theory could be obtained by dimensionally reducing Einstein-Maxwell theory with a cosmological constant to a lower dimension. These (neutral/magnetic/electric charged) solutions can have a (two) black hole horizon(s), cosmological horizon, or a naked singularity. Black hole horizon or cosmological horizon of these solutions can be a hypersurface of positive, zero or negative constant curvature. These exact solutions are neither asymptotically flat, nor asymptotically AdS/dS. But some of them can be uplifted to a higher dimension, and those higher dimensional solutions are either asymptotically flat, or asymptotically AdS/dS with/without a compact constant curvature space. This observation is useful to better understand holographic properties of these nonasymptotically AdS/dS solutions.

  12. Process and apparatus for adding and removing particles from pressurized reactors

    DOE Patents [OSTI]

    Milligan, John D.

    1983-01-01

    A method for adding and removing fine particles from a pressurized reactor is provided, which comprises connecting the reactor to a container, sealing the container from the reactor, filling the container with particles and a liquid material compatible with the reactants, pressurizing the container to substantially the reactor pressure, removing the seal between the reactor and the container, permitting particles to fall into or out of the reactor, and resealing the container from the reactor. An apparatus for adding and removing particles is also disclosed.

  13. Adding Links in Energy.gov Content Management System | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy.gov Content Management System ¬Ľ Adding Links in Energy.gov Content Management System Adding Links in Energy.gov Content Management System For Office of Energy Efficiency and Renewable Energy (EERE) websites, to add a link in the Energy.gov Drupal content management system (CMS), follow these steps: Edit the page (also called a node) that you want to add a link to. Select the text you want to link. Click the "Link" button. Then: If you are linking to a page on Energy.gov, select

  14. Adding "Utilization" to Carbon Capture and Storage | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Adding "Utilization" to Carbon Capture and Storage Adding "Utilization" to Carbon Capture and Storage May 1, 2012 - 4:23pm Addthis Greater application of CO2-EOR could yield a significant boost to the U.S. economy, including increased economic activity, improved balance of trade, job creation, and reduced oil imports. Greater application of CO2-EOR could yield a significant boost to the U.S. economy, including increased economic activity, improved balance of trade,

  15. I INSTRUCTIONS: FROM: Accountability Station Energy Library, AD-622.1/GTN

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    I INSTRUCTIONS: FROM: Accountability Station Energy Library, AD-622.1/GTN U.S. Department of Energy P.O. Box A Germantown, MD 20874 Document Number Copy Series Classi- fication Date Due TO: I have personally received the material identified above and assume full responsibility for its safe handling in accordance with existing regulations. Date Signature Postal Registry No. AD F 1430.1 (11-92) U.S. DEPARTMENT OF ENERGY WASHINGTON, D.C. ENERGY LIBRARY CLASSIFIED RECEIPT NO. T 1. Original of this

  16. Interim Chronic Beryllium Disease

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-12-08

    Establishes Departmental expectations for addressing chronic beryllium disease throughout the Department until a Departmental rule on beryllium is promulgated. This Notice was replaced by final rule 10 CFR Part 850, Chronic Beryllium Disease Prevention Program, published December 8, 1999.

  17. Superstrings on AdS{sub 4}xCP{sup 3} from supergravity

    SciTech Connect (OSTI)

    D'Auria, Riccardo; Trigiante, Mario; Fre, Pietro; Grassi, Pietro Antonio

    2009-04-15

    We derive from a general formulation of pure spinor string theory on type IIA backgrounds the specific form of the action for the AdS{sub 4}xCP{sup 3} background. We provide a complete geometrical characterization of the structure of the superfields involved in the action.

  18. Expert Meeting Report. Key Innovations for Adding Energy Efficiency to Maintenance Projects

    SciTech Connect (OSTI)

    Wood, A.; Wiehagen, J.

    2012-09-01

    This report describes an expert meeting hosted by the Building America research team NAHB Research Center, which was held on February 8, 2012, in Orlando, Florida. The topic focused on efforts to increase the efficiency of existing homes, specifically for re-roofing and the opportunities for adding energy efficiency upgrades during this major home repair activity.

  19. G-Band Vapor Radiometer Precipitable Water Vapor (GVRPWV) Value-Added Product

    SciTech Connect (OSTI)

    Koontz, A; Cadeddu, M

    2012-12-05

    The G-Band Vapor Radiometer Precipitable Water Vapor (GVRPWV) value-added product (VAP) computes precipitable water vapor using neural network techniques from data measured by the GVR. The GVR reports time-series measurements of brightness temperatures for four channels located at 183.3 ¬Ī 1, 3, 7, and 14 GHz.

  20. Evaluation of the Ad Council/DOE ¬ćWhat¬źs Your Excuse¬é Public...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... Across all four outcomes, one or both of the control variables (predilection to save energy and perceived difficulty of saving energy) were statistically significant. Ad ...

  1. Dilatonic repulsons and confinement via the AdS/CFT correspondence

    SciTech Connect (OSTI)

    Bak, Dongsu; Gutperle, Michael; Hirano, Shinji; Ohta, Nobuyoshi

    2004-10-15

    We study a class of dilatonic deformations of asymptotically AdS{sub 5}xS{sup 5} geometry analytically and numerically. The spacetime is nonsupersymmetric and suffers from a naked singularity. We propose that the causality bound may serve as a criterion for such a geometry with a naked singularity to still make sense in the AdS/CFT correspondence. We show that the static string, the one corresponding to a large Wilson loop in the dual gauge theory, reveals confinement in a certain range of parameters of our solutions, where the singularity exhibits the repulsion that can well cloak the singularity from the static string probe. In particular, we find the exact expression for the tension of the QCD strings. We also discuss a possible interpretation of our solution in terms of unstable branes and their tachyon matter.

  2. Added Value of Reliability to a Microgrid: Simulations of Three California Buildings

    SciTech Connect (OSTI)

    Marnay, Chris; Lai, Judy; Stadler, Michael; Siddiqui, Afzal

    2009-05-07

    The Distributed Energy Resources Customer Adoption Model is used to estimate the value an Oakland nursing home, a Riverside high school, and a Sunnyvale data center would need to put on higher electricity service reliability for them to adopt a Consortium for Electric Reliability Technology Solutions Microgrid (CM) based on economics alone. A fraction of each building's load is deemed critical based on its mission, and the added cost of CM capability to meet it added to on-site generation options. The three sites are analyzed with various resources available as microgrid components. Results show that the value placed on higher reliability often does not have to be significant for CM to appear attractive, about 25 $/kWcdota and up, but the carbon footprint consequences are mixed because storage is often used to shift cheaper off-peak electricity to use during afternoon hours in competition with the solar sources.

  3. PNNI routing support for ad hoc mobile networking: A flat architecture

    SciTech Connect (OSTI)

    Martinez, L.; Sholander, P.; Tolendino, L.

    1997-12-01

    This contribution extends the Outside Nodal Hierarchy List (ONHL) procedures described in ATM Form Contribution 97-0766. These extensions allow multiple mobile networks to form either an ad hoc network or an extension of a fixed PNNI infrastructure. This contribution covers the simplest case where the top-most Logical Group Nodes (LGNs), in those mobile networks, all reside at the same level in a PNNI hierarchy. Future contributions will cover the general case where those top-most LGNs reside at different hierarchy levels. This contribution considers a flat ad hoc network architecture--in the sense that each mobile network always participates in the PNNI hierarchy at the preconfigured level of its top-most LGN.

  4. First measurement of ADS parameters using $B^- \\to D^0K^-$ decays in hadron collisions

    SciTech Connect (OSTI)

    Garosi, Paola; /Siena U. /INFN, Pisa

    2011-06-01

    Measurements of branching fractions and CP-asymmetries of B{sup -} {yields} D{sup 0}K{sup -} modes allow a theoretically-clean extraction of the CKM angle {gamma}. The method proposed by Atwood, Dunietz and Soni (ADS) makes use of a decay chain where color and Cabibbo suppression interfere, which produces large CP-violating asymmetries. The CDF experiment reports the first measurement at a hadron collider of branching fractions and CP-asymmetries of suppressed B{sup -} {yields} D{sup 0}h{sup -} signals, where h is {pi} or K. Using 5.0 fb{sup -1} of data we found a combined significance exceeding 5{sigma} and we determined the ADS parameters with accuracy comparable with B-factories.

  5. Exact quantization of a superparticle in AdS{sub 5}xS{sup 5}

    SciTech Connect (OSTI)

    Horigane, Tetsuo; Kazama, Yoichi

    2010-02-15

    As a step toward deeper understanding of the AdS/CFT correspondence, exact quantization of a Brink-Schwarz superparticle in the AdS{sub 5}xS{sup 5} background with Ramond-Ramond flux is performed from the first principle in the phase space formulation. It includes the construction of the quantum Noether charges for the psu(2,2|4) superconformal symmetry and by solving the superconformal primary conditions we obtain the complete physical spectrum of the system with the explicit wave functions. The spectrum agrees precisely with the supergravity results, including all the Kaluza-Klein excitations. Our method and the result are expected to shed light on the eventual quantization of a superstring in this important background.

  6. DOE/SC-ARM-TR-140 Droplet Number Concentration Value-Added Product

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    0 Droplet Number Concentration Value-Added Product L Riihimaki S McFarlane C Sivaraman June 2014 Version 1.0 DISCLAIMER This report was prepared as an account of work sponsored by the U.S. Government. Neither the United States nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its

  7. DOE/SC-ARM/TR-087 Merged Sounding Value-Added Product D Troyan

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    87 Merged Sounding Value-Added Product D Troyan March 2012 DISCLAIMER This report was prepared as an account of work sponsored by the U.S. Government. Neither the United States nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights.

  8. DOE/SC-ARM/TR-098 Micropulse Lidar Cloud Mask Value-Added Product Technical Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    8 Micropulse Lidar Cloud Mask Value-Added Product Technical Report C Sivaraman J Comstock July 2011 DISCLAIMER This report was prepared as an account of work sponsored by the U.S. Government. Neither the United States nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would

  9. DOE/SC-ARM/TR-115 Aerosol Best Estimate (AEROSOLBE) Value-Added Product

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    5 Aerosol Best Estimate (AEROSOLBE) Value-Added Product C Flynn D Turner A Koontz D Chand C Sivaraman July 2012 DISCLAIMER This report was prepared as an account of work sponsored by the U.S. Government. Neither the United States nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that

  10. DOE/SC-ARM/TR-129 Aerosol Optical Depth Value-Added Product

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    9 Aerosol Optical Depth Value-Added Product A Koontz C Flynn G Hodges J Michalsky J Barnard March 2013 DISCLAIMER This report was prepared as an account of work sponsored by the U.S. Government. Neither the United States nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use

  11. Methods for conversion of carbohydrates in ionic liquids to value-added chemicals

    DOE Patents [OSTI]

    Zhao, Haibo; Holladay, Johnathan E.

    2011-05-10

    Methods are described for converting carbohydrates including, e.g., monosaccharides, disaccharides, and polysaccharides in ionic liquids to value-added chemicals including furans, useful as chemical intermediates and/or feedstocks. Fructose is converted to 5-hydroxylmethylfurfural (HMF) in the presence of metal halide and acid catalysts. Glucose is effectively converted to HMF in the presence of chromium chloride catalysts. Yields of up to about 70% are achieved with low levels of impurities such as levulinic acid.

  12. Quality improvement of pyrolysis oil from waste rubber by adding sawdust

    SciTech Connect (OSTI)

    Wang, Wen-liang; Chang, Jian-min; Cai, Li-ping; Shi, Sheldon Q.

    2014-12-15

    Highlights: ‚ÄĘ Rubber-pyrolysis oil is difficult to be fuel due to high proportion of PAHs. ‚ÄĘ The efficiency of pyrolysis was increased as the percentage of sawdust increased. ‚ÄĘ The adding of sawdust improved pyrolysis oil quality by reducing the PAHs content. ‚ÄĘ Adding sawdust reduced nitrogen/sulfur in oil and was easier to convert to diesel. - Abstract: This work was aimed at improving the pyrolysis oil quality of waste rubber by adding larch sawdust. Using a 1 kg/h stainless pyrolysis reactor, the contents of sawdust in rubber were gradually increased from 0%, 50%, 100% and 200% (wt%) during the pyrolysis process. Using a thermo-gravimetric (TG) analyzer coupled with Fourier transform infrared (FTIR) analysis of evolving products (TG‚ÄďFTIR), the weight loss characteristics of the heat under different mixtures of sawdust/rubber were observed. Using the pyrolysis‚Äďgas chromatography (GC)‚Äďmass spectrometry (Py‚ÄďGC/MS), the vapors from the pyrolysis processes were collected and the compositions of the vapors were examined. During the pyrolysis process, the recovery of the pyrolysis gas and its composition were measured in-situ at a reaction temperature of 450 ¬įC and a retaining time of 1.2 s. The results indicated that the efficiency of pyrolysis was increased and the residual carbon was reduced as the percentage of sawdust increased. The adding of sawdust significantly improved the pyrolysis oil quality by reducing the polycyclic aromatic hydrocarbons (PAHs) and nitrogen and sulfur compounds contents, resulting in an improvement in the combustion efficiency of the pyrolysis oil.

  13. ARM Climate Research Facility Quarterly Value-Added Product Report, Fourth Quarter

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    72 ARM Climate Research Facility Quarterly Value-Added Product Report C Sivaraman October 2015 DISCLAIMER This report was prepared as an account of work sponsored by the U.S. Government. Neither the United States nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not

  14. Method for conversion of carbohydrate polymers to value-added chemical products

    DOE Patents [OSTI]

    Zhang, Zongchao C.; Brown, Heather M.; Su, Yu

    2012-02-07

    Methods are described for conversion of carbohydrate polymers in ionic liquids, including cellulose, that yield value-added chemicals including, e.g., glucose and 5-hydroxylmethylfurfural (HMF) at temperatures below 120.degree. C. Catalyst compositions that include various mixed metal halides are described that are selective for specified products with yields, e.g., of up to about 56% in a single step process.

  15. Recent Developments on the Broadband Heating Rate Profile Value-Added Product

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Recent Developments on the Broadband Heating Rate Profile Value-Added Product E. J. Mlawer, J. S. Delamere, and S. A. Clough Atmospheric and Environmental Research, Inc. Cambridge, Massachusetts M. A. Miller and K. L. Johnson Brookhaven National Laboratory Upton, New York T. R. Shippert and C. N. Long Pacific Northwest National Laboratory Richland, Washington R. G. Ellingson Florida State University Tallahassee, Florida M. H. Zhang State University of New York - Stony Brook Albany, New York R.

  16. Microsoft Word - ARM Value-Added Product_tech_rpt_v2.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    77 An Atmospheric Radiation Measurement Value-Added Product to Retrieve Optically Thin Cloud Visible Optical Depth using Micropulse Lidar October 2006 Chaomei Lo Jennifer M. Comstock Connor Flynn Pacific Northwest National Laboratory Richland, Washington Work supported by the U.S. Department of Energy, Office of Energy Research, Office of Biological and Environmental Research C Lo, JM Comstock, C Flynn, October 2006, ARM TR-077 iii Contents 1 Introduction

  17. Catalytic Conversion of Biomass-derived Feedstock (HMF) into Value Added

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Chemicals and Biofuels - Energy Innovation Portal Industrial Technologies Industrial Technologies Biomass and Biofuels Biomass and Biofuels Find More Like This Return to Search Catalytic Conversion of Biomass-derived Feedstock (HMF) into Value Added Chemicals and Biofuels Colorado State University Contact CSU About This Technology Technology Marketing Summary A catalytic reaction system by which the biomass-derived feedstock chemical HMF can be upgraded into a higher carbon content

  18. Flying across Galaxy Clusters with Google Earth: additional imagery from SDSS co-added data

    SciTech Connect (OSTI)

    Hao, Jiangang; Annis, James; /Fermilab

    2010-10-01

    Galaxy clusters are spectacular. We provide a Google Earth compatible imagery for the deep co-added images from the Sloan Digital Sky Survey and make it a tool for examing galaxy clusters. Google Earth (in sky mode) provides a highly interactive environment for visualizing the sky. By encoding the galaxy cluster information into a kml/kmz file, one can use Google Earth as a tool for examining galaxy clusters and fly across them freely. However, the resolution of the images provided by Google Earth is not very high. This is partially because the major imagery google earth used is from Sloan Digital Sky Survey (SDSS) (SDSS collaboration 2000) and the resolutions have been reduced to speed up the web transferring. To have higher resolution images, you need to add your own images in a way that Google Earth can understand. The SDSS co-added data are the co-addition of {approx}100 scans of images from SDSS stripe 82 (Annis et al. 2010). It provides the deepest images based on SDSS and reach as deep as about redshift 1.0. Based on the co-added images, we created color images in a way as described by Lupton et al. (2004) and convert the color images to Google Earth compatible images using wcs2kml (Brewer et al. 2007). The images are stored at a public server at Fermi National Accelerator Laboratory and can be accessed by the public. To view those images in Google Earth, you need to download a kmz file, which contains the links to the color images, and then open the kmz file with your Google Earth. To meet different needs for resolutions, we provide three kmz files corresponding to low, medium and high resolution images. We recommend the high resolution one as long as you have a broadband Internet connection, though you should choose to download any of them, depending on your own needs and Internet speed. After you open the downloaded kmz file with Google Earth (in sky mode), it takes about 5 minutes (depending on your Internet connection and the resolution of images you

  19. Adventures in Infectious Diseases

    ScienceCinema (OSTI)

    Fisher-Hoch, Susan [University of Texas School of Public Health

    2014-06-25

    Dr. Susan Fisher-Hoch, Virologist and Epidemiologist, will discuss her research and travels associated with viral hemorrhagic fevers. From the Ebola outbreak in Reston, Virginia to outbreaks of Crimean Congo Hemorrhagic Fever in South Africa, Senegal, and Saudi Arabia, Dr. Fisher-Hoch has studied and tracked the pathophysiology of these viral diseases. These studies have led her from the Center for Disease Control in the United States, to Lyon, France where she was instrumental in designing, constructing, and rendering operational a laboratory capable of containing some of the world's most dangerous diseases.

  20. Reconstruction of spatial patterns of climatic anomalies during the medieval warm period (AD 900-1300)

    SciTech Connect (OSTI)

    Diaz, H.F.; Hughes, M.K.

    1992-12-31

    The workshop will focus on climatic variations during the Medieval Warm Period or Little Climatic Optimum. The nominal time interval assigned to this period is AD 900--1300, but climate information available during the century or two preceding and following this episode is welcome. The aims of the workshop will be to: examine the available evidence for the existence of this episode; assess the spatial and temporal synchronicity of the climatic signals; discuss possible forcing mechanisms; and identify areas and paleoenvironmental records where additional research efforts are needed to improve our knowledge of this period. This document consists of abstracts of eighteen papers presented at the meeting.

  1. DOE/SC-ARM/TR-133 Aerosol Optical Depth Value-Added

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3 Aerosol Optical Depth Value-Added Product for the SAS-He Instrument B Ermold CJ Flynn J Barnard September 2013 Version 1.0 DISCLAIMER This report was prepared as an account of work sponsored by the U.S. Government. Neither the United States nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or

  2. System for adding sulfur to a fuel cell stack system for improved fuel cell stability

    DOE Patents [OSTI]

    Mukerjee, Subhasish; Haltiner, Jr., Karl J; Weissman, Jeffrey G

    2013-08-13

    A system for adding sulfur to a reformate stream feeding a fuel cell stack, having a sulfur source for providing sulfur to the reformate stream and a metering device in fluid connection with the sulfur source and the reformate stream. The metering device injects sulfur from the sulfur source to the reformate stream at a predetermined rate, thereby providing a conditioned reformate stream to the fuel cell stack. The system provides a conditioned reformate stream having a predetermined sulfur concentration that gives an acceptable balance of minimal drop in initial power with the desired maximum stability of operation over prolonged periods for the fuel cell stack.

  3. Functionally gradient material for membrane reactors to convert methane gas into value-added products

    DOE Patents [OSTI]

    Balachandran, U.; Dusek, J.T.; Kleefisch, M.S.; Kobylinski, T.P.

    1996-11-12

    A functionally gradient material for a membrane reactor for converting methane gas into value-added-products includes an outer tube of perovskite, which contacts air; an inner tube which contacts methane gas, of zirconium oxide, and a bonding layer between the perovskite and zirconium oxide layers. The bonding layer has one or more layers of a mixture of perovskite and zirconium oxide, with the layers transitioning from an excess of perovskite to an excess of zirconium oxide. The transition layers match thermal expansion coefficients and other physical properties between the two different materials. 7 figs.

  4. Functionally gradient material for membrane reactors to convert methane gas into value-added products

    DOE Patents [OSTI]

    Balachandran, Uthamalingam; Dusek, Joseph T.; Kleefisch, Mark S.; Kobylinski, Thadeus P.

    1996-01-01

    A functionally gradient material for a membrane reactor for converting methane gas into value-added-products includes an outer tube of perovskite, which contacts air; an inner tube which contacts methane gas, of zirconium oxide, and a bonding layer between the perovskite and zirconium oxide layers. The bonding layer has one or more layers of a mixture of perovskite and zirconium oxide, with the layers transitioning from an excess of perovskite to an excess of zirconium oxide. The transition layers match thermal expansion coefficients and other physical properties between the two different materials.

  5. Combustion process and nitrogen oxides emission of Shenmu coal added with sodium acetate

    SciTech Connect (OSTI)

    Yang Weijuan; Zhou Junhu; Liu Maosheng; Zhou Zhijun; Liu Jianzhong; Cen Kefa

    2007-09-15

    Shenmu bituminous coal with 4% sodium acetate added was used to investigate the characteristics of combustion and nitrogen oxide (NOx) release in a fixed bed reactor heated by a tube furnace. The composition of the flue gas was analyzed to investigate the effects of sodium acetate on the combustion process and NOx emission. The experiments were carried out in a partial reductive atmosphere and a strong oxidative atmosphere. The O{sub 2} valley value in the partial reductive atmosphere was reduced by the added sodium acetate. Sodium acetate accelerated the combustion and shortened the combustion process. The experimental results showed that the emissions of NO, NO{sub 2}, and N{sub 2}O were affected by the reacting atmosphere and the combustion temperature. In the strong oxidative atmosphere, sodium acetate resulted in a slight NOx reduction. In the partial reductive atmosphere, sodium acetate reduced both the peak value of NO concentration and the total NO emission significantly. An over 30% NOx reduction efficiency was achieved at 900{sup o}C in the partial reductive atmosphere, which decreased with the increase in temperature. Sodium acetate was decomposed into hydrocarbon radicals and sodium hydroxide, which can both reduce NOx emissions due to their special reactions with the nitrogen component. 17 refs., 11 figs., 2 tabs.

  6. Atmospheric Radiation Measurement (ARM) Value-Added Data Products (Including Evaluated Data Sets)

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Many of the scientific needs of the ARM Program are met through the analysis and processing of existing data products into "value-added" products or VAPs. Despite extensive instrumentation deployed at the ARM sites, there will always be quantities of interest that are either impractical or impossible to measure directly or routinely. Physical models using ARM instrument data as inputs are implemented as VAPs and can help fill some of the unmet measurement needs of the Program. Conversely, ARM produces some VAPs not in order to fill unmet measurement needs, but instead to improve the quality of existing measurements. In addition, when more than one measurement is available, ARM also produces "best estimate" VAPs. A special class of VAP called a Quality Measurement Experiment (QME) adds value to the input data streams by providing for continuous assessment of the quality of the input data. [taken from http://www.arm.gov/data/vaps_all.php] One of the ARM data centers, the External Data Center or XDC at Brookhaven National Laboratory, also adds value to ARM information by identifying sources and acquiring external data to augment the data being generated within the program. These external data sets are converted, processed, and carefully evaluated for their value to the overall ARM program. /. Data Plots are also value-added products from ARM.

  7. Flat space S matrix from the AdS/CFT correspondence?

    SciTech Connect (OSTI)

    Gary, Michael; Giddings, Steven B.

    2009-08-15

    We investigate recovery of the bulk S matrix from the AdS/CFT correspondence, at large radius. It was recently argued that some of the elements of the S matrix might be read from CFT correlators, given a particular singularity structure of the latter, but leaving the question of more general S matrix elements. Since in AdS/CFT, data must be specified on the boundary, we find certain limitations on the corresponding bulk wave packets and on their localization properties. In particular, those we have found that approximately localize have low-energy tails, and corresponding power-law tails in position space. When their scattering is compared to that of 'sharper' wave packets typically used in scattering theory, one finds apparently significant differences, suggesting a possible lack of resolution via these wave packets. We also give arguments that construction of the sharper wave packets may require nonperturbative control of the boundary theory, and particularly of the N{sup 2} matrix degrees of freedom. These observations thus raise interesting questions about what principle would guarantee the appropriate control, and about how a boundary CFT can accurately approximate the flat space S matrix.

  8. Value Added Products from Hemicellulose Utilization in Dry Mill Ethanol Plants

    SciTech Connect (OSTI)

    Rodney Williamson, ICPB; John Magnuson, PNNL; David Reed, INL; Marco Baez, Dyadic; Marion Bradford, ICPB

    2007-03-30

    The Iowa Corn Promotion Board is the principal contracting entity for this grant funded by the US Department of Agriculture and managed by the US Department of Energy. The Iowa Corn Promotion Board subcontracted with New Jersey Institute of Technology, KiwiChem, Pacific Northwest National Lab and Idaho National Lab to conduct research for this project. KiwiChem conducted the economic engineering assessment of a dry-mill ethanol plant. New Jersey Institute of Technology conducted work on incorporating the organic acids into polymers. Pacific Northwest National Lab conducted work in hydrolysis of hemicellulose, fermentation and chemical catalysis of sugars to value-added chemicals. Idaho National Lab engineered an organism to ferment a specific organic acid. Dyadic, an enzme company, was a collaborator which provided in-kind support for the project. The Iowa Corn Promotion Board collaborated with the Ohio Corn Marketing Board and the Minnesota Corn Merchandising Council in providing cost share for the project. The purpose of this diverse collaboration was to integrate the hydrolysis, the conversion and the polymer applications into one project and increase the likelihood of success. This project had two primary goals: (1) to hydrolyze the hemicellulose fraction of the distillers grain (DG) coproduct coming from the dry-mill ethanol plants and (2) convert the sugars derived from the hemicellulose into value-added co-products via fermentation and chemical catalysis.

  9. Value-Added Products from FGD Sulfite-Rich Scrubber Materials

    SciTech Connect (OSTI)

    Vivak Malhotra

    2010-01-31

    According to the American Coal Ash Association, about 29.25 million tons of flue gas desulfurization (FGD) byproducts were produced in the USA in 2003. Out of 29.25 million tons, 17.35 million tons were sulfite-rich scrubber materials. At present, unlike its cousin FGD gypsum, the prospect for effective utilization of sulfite-rich scrubber materials is not bright. In fact, almost 16.9 million tons are leftover every year. In our pursuit to mitigate the liability of sulfite-rich FGD scrubber materials' disposal, we are attempting to develop value-added products that can commercially compete. More specifically, for this Innovative Concept Phase I project, we have the following objectives: to characterize the sulfite-rich scrubber material for toxic metals; to optimize the co-blending and processing of scrubber material and natural byproducts; to formulate and develop structural composites from sulfite-rich scrubber material; and to evaluate the composites' mechanical properties and compare them with current products on the market. After successfully demonstrating the viability of our research, a more comprehensive approach will be proposed to take these value-added materials to fruition.

  10. EA-0896: Finding of No Significant Impact

    Broader source: Energy.gov [DOE]

    Center for Nuclear Medicine Research in Alzheimer's Disease Health Sciences Center- West Virginia University

  11. EA-0896: Final Environmental Assessment

    Broader source: Energy.gov [DOE]

    Center for Nuclear Medicine Research in Alzheimer's Disease Health Sciences Center- West Virginia University

  12. Energy-efficient distributed constructions of miniumum spanning tree for wireless ad-hoc networks

    SciTech Connect (OSTI)

    Kumar, V. S. A.; Pandurangan, G.; Khan, M.

    2004-01-01

    The Minimum Spanning Tree (MST) problem is one of the most important and commonly occurring primitive in the design and operation of data and communication networks. While there a redistributed algorithms for the MST problem these require relatively large number of messages and time, and are fairly involved, require synchronization and a lot of book keeping; this makes these algorithms impractical for emerging technologies such as ad hoc and sensor networks. In such networks, a sensor has very limited power, and any algorithm needs to be simple, local and energy efficient for being practical. Motivated by these considerations, we study the performance of a class of simple and local algorithms called Nearest Neighbor Tree (NNT) algorithms for energy-efficient construction of MSTs in a wireless ad hoc setting. These employ a very simple idea to eliminate the work involved in cycle detection in other MST algorithms: each node chooses a distinct rank, and connects to the closest node of higher rank. We consider two variants of the NNT algorithms, obtained by two ways of choosing the ranks: (i) Random NNT, in which each node chooses a rank randomly, and (ii) Directional NNT, in which each node uses directional information for choosing the rank. We show provable bounds on the performance of these algorithms in instances obtained by uniformly distributed points in the unit square. Finally, we perform extensive simulations of our algorithms. We tested our algorithms on both uniformly random distributions of points, and on realistic distributions of points in an urban setting. The cost of the tree found by the NNT algorithms is within a factor of 2 of the MST, but there is more than a ten-fold saving on the energy and about a five fold saving on the number of messages sent. Also, our algorithms are significantly simpler to implement compared to, for instance, the GHS algorithm, which is essentially optimal with regards to the message complexity. Thus, our results

  13. ARM Climate Research Facility Spectral Surface Albedo Value-Added Product (VAP) Report

    SciTech Connect (OSTI)

    McFarlane, S; Gaustad, K; Long, C; Mlawer, E

    2011-07-15

    This document describes the input requirements, output data products, and methodology for the Spectral Surface Albedo (SURFSPECALB) value-added product (VAP). The SURFSPECALB VAP produces a best-estimate near-continuous high spectral resolution albedo data product using measurements from multifilter radiometers (MFRs). The VAP first identifies best estimates for the MFR downwelling and upwelling shortwave irradiance values, and then calculates narrowband spectral albedo from these best-estimate irradiance values. The methodology for finding the best-estimate values is based on a simple process of screening suspect data and backfilling screened and missing data with estimated values when possible. The resulting best-estimate MFR narrowband spectral albedos are used to determine a daily surface type (snow, 100% vegetation, partial vegetation, or 0% vegetation). For non-snow surfaces, a piecewise continuous function is used to estimate a high spectral resolution albedo at 1 min temporal and 10 cm-1 spectral resolution.

  14. Hamiltonian Light-front Field Theory Within an AdS/QCD Basis

    SciTech Connect (OSTI)

    Vary, J.P.; Honkanen, H.; Li, Jun; Maris, P.; Brodsky, S.J.; Harindranath, A.; de Teramond, G.F.; Sternberg, P.; Ng, E.G.; Yang, C.; /LBL, Berkeley

    2009-12-16

    Non-perturbative Hamiltonian light-front quantum field theory presents opportunities and challenges that bridge particle physics and nuclear physics. Fundamental theories, such as Quantum Chromodynamics (QCD) and Quantum Electrodynamics (QED) offer the promise of great predictive power spanning phenomena on all scales from the microscopic to cosmic scales, but new tools that do not rely exclusively on perturbation theory are required to make connection from one scale to the next. We outline recent theoretical and computational progress to build these bridges and provide illustrative results for nuclear structure and quantum field theory. As our framework we choose light-front gauge and a basis function representation with two-dimensional harmonic oscillator basis for transverse modes that corresponds with eigensolutions of the soft-wall AdS/QCD model obtained from light-front holography.

  15. System for adding sulfur to a fuel cell stack system for improved fuel cell stability

    DOE Patents [OSTI]

    Mukerjee, Subhasish; Haltiner, Jr., Karl J; Weissman, Jeffrey G.

    2012-03-06

    A system for adding sulfur to a fuel cell stack, having a reformer adapted to reform a hydrocarbon fuel stream containing sulfur contaminants, thereby providing a reformate stream having sulfur; a sulfur trap fluidly coupled downstream of the reformer for removing sulfur from the reformate stream, thereby providing a desulfurized reformate stream; and a metering device in fluid communication with the reformate stream upstream of the sulfur trap and with the desulfurized reformate stream downstream of the sulfur trap. The metering device is adapted to bypass a portion of the reformate stream to mix with the desulfurized reformate stream, thereby producing a conditioned reformate stream having a predetermined sulfur concentration that gives an acceptable balance of minimal drop in initial power with the desired maximum stability of operation over prolonged periods for the fuel cell stack.

  16. Value-Added Products From FGD Sulfite-Rich Scrubber Materials

    SciTech Connect (OSTI)

    Vivak M. Malhotra

    2006-09-30

    Massive quantities of sulfite-rich flue gas desulfurization (FGD) scrubber materials are produced every year in the USA. In fact, at present, the production of wet sulfite-rich scrubber cake outstrips the production of wet sulfate-rich scrubber cake by about 6 million tons per year. However, most of the utilization focus has centered on FGD gypsum. Therefore, we have recently initiated research on developing new strategies for the economical, but environmentally-sound, utilization of sulfite-rich scrubber material. In this exploratory project (Phase I), we attempted to ascertain whether it is feasible to develop reconstituted wood replacement products from sulfite-rich scrubber material. In pursuit of this goal, we characterized two different wet sulfite-rich scrubber materials, obtained from two power plants burning Midwestern coal, for their suitability for the development of value-added products. The overall strategy adopted was to fabricate composites where the largest ingredient was scrubber material with additional crop materials as additives. Our results suggested that it may be feasible to develop composites with flexural strength as high as 40 MPa (5800 psi) without the addition of external polymers. We also attempted to develop load-bearing composites from scrubber material, natural fibers, and phenolic polymer. The polymer-to-solid ratio was limited to {le} 0.4. The formulated composites showed flexural strengths as high as 73 MPa (10,585 psi). We plan to harness the research outcomes from Phase I to develop parameters required to upscale our value-added products in Phase II.

  17. Gas bubble disease: introduction

    SciTech Connect (OSTI)

    Fickeisen, D.H.; Schneider, M.J.; Wedemeyer, G.A.

    1980-11-01

    In 1970, gas bubble disease was identified as a serious problem affecting salmonids in the Columbia and Snake river systems. The source of supersaturation was entrainment of air into water spilling over hydroelectric dams. Regional research projects focusing on tolerance bioassays were immediately implemented. Since then, the scope of gas bubble disease research has broadened to include problems in other aquatic systems, with other species. Emphasis has shifted from defining tolerance limits in bioassay systems to exploring behavioral and physiological aspects. Various methods of degasifying supersaturated water have been developed.

  18. Using Wikipedia to forecast diseases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Using Wikipedia to forecast diseases Using Wikipedia to forecast diseases Scientists can now monitor and forecast diseases around the globe more effectively by analyzing views of Wikipedia articles. November 13, 2014 Del Valle and her team observe findings from their research on disease patterns from analyzing Wikipedia articles. Del Valle and her team observe findings from their research on disease patterns from analyzing Wikipedia articles. Contact Nancy Ambrosiano Communications Office (505)

  19. Virtual machine-based simulation platform for mobile ad-hoc network-based cyber infrastructure

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Yoginath, Srikanth B.; Perumalla, Kayla S.; Henz, Brian J.

    2015-09-29

    In modeling and simulating complex systems such as mobile ad-hoc networks (MANETs) in de-fense communications, it is a major challenge to reconcile multiple important considerations: the rapidity of unavoidable changes to the software (network layers and applications), the difficulty of modeling the critical, implementation-dependent behavioral effects, the need to sustain larger scale scenarios, and the desire for faster simulations. Here we present our approach in success-fully reconciling them using a virtual time-synchronized virtual machine(VM)-based parallel ex-ecution framework that accurately lifts both the devices as well as the network communications to a virtual time plane while retaining full fidelity. At themore¬†¬Ľ core of our framework is a scheduling engine that operates at the level of a hypervisor scheduler, offering a unique ability to execute multi-core guest nodes over multi-core host nodes in an accurate, virtual time-synchronized manner. In contrast to other related approaches that suffer from either speed or accuracy issues, our framework provides MANET node-wise scalability, high fidelity of software behaviors, and time-ordering accuracy. The design and development of this framework is presented, and an ac-tual implementation based on the widely used Xen hypervisor system is described. Benchmarks with synthetic and actual applications are used to identify the benefits of our approach. The time inaccuracy of traditional emulation methods is demonstrated, in comparison with the accurate execution of our framework verified by theoretically correct results expected from analytical models of the same scenarios. In the largest high fidelity tests, we are able to perform virtual time-synchronized simulation of 64-node VM-based full-stack, actual software behaviors of MANETs containing a mix of static and mobile (unmanned airborne vehicle) nodes, hosted on a 32-core host, with full fidelity of unmodified ad-hoc routing protocols, unmodified

  20. Virtual machine-based simulation platform for mobile ad-hoc network-based cyber infrastructure

    SciTech Connect (OSTI)

    Yoginath, Srikanth B.; Perumalla, Kayla S.; Henz, Brian J.

    2015-09-29

    In modeling and simulating complex systems such as mobile ad-hoc networks (MANETs) in de-fense communications, it is a major challenge to reconcile multiple important considerations: the rapidity of unavoidable changes to the software (network layers and applications), the difficulty of modeling the critical, implementation-dependent behavioral effects, the need to sustain larger scale scenarios, and the desire for faster simulations. Here we present our approach in success-fully reconciling them using a virtual time-synchronized virtual machine(VM)-based parallel ex-ecution framework that accurately lifts both the devices as well as the network communications to a virtual time plane while retaining full fidelity. At the core of our framework is a scheduling engine that operates at the level of a hypervisor scheduler, offering a unique ability to execute multi-core guest nodes over multi-core host nodes in an accurate, virtual time-synchronized manner. In contrast to other related approaches that suffer from either speed or accuracy issues, our framework provides MANET node-wise scalability, high fidelity of software behaviors, and time-ordering accuracy. The design and development of this framework is presented, and an ac-tual implementation based on the widely used Xen hypervisor system is described. Benchmarks with synthetic and actual applications are used to identify the benefits of our approach. The time inaccuracy of traditional emulation methods is demonstrated, in comparison with the accurate execution of our framework verified by theoretically correct results expected from analytical models of the same scenarios. In the largest high fidelity tests, we are able to perform virtual time-synchronized simulation of 64-node VM-based full-stack, actual software behaviors of MANETs containing a mix of static and mobile (unmanned airborne vehicle) nodes, hosted on a 32-core host, with full fidelity of unmodified ad-hoc routing protocols, unmodified application

  1. A Time-Slotted On-Demand Routing Protocol for Mobile Ad Hoc Unmanned Vehicle Systems

    SciTech Connect (OSTI)

    Hope Forsmann; Robert Hiromoto; John Svoboda

    2007-04-01

    The popularity of UAVs has increased dramatically because of their successful deployment in military operations, their ability to preserve human life, and the continual improvements in wireless communication that serves to increase their capabilities. We believe the usefulness of UAVs would be dramatically increased if formation flight were added to the list of capabilities. Currently, sustained formation flight with a cluster of UAVs has only been achieved with two nodes by the Multi-UAV Testbed at the Massachusetts Institute of Technology. (Park, 2004) Formation flight is a complex operation requiring the ability to adjust the flight patterns on the fly and correct for wind gusts, terrain, and differences in node equipment. All of which increases the amount of inner node communication. Since one of the problems with MANET communication is network congestion, we believe a first step towards formation flight can be made through improved inner node communication. We have investigated current communication routing protocols and developed an altered hybrid routing protocol in order to provide communication with less network congestion.

  2. Semiclassical circular strings in AdS{sub 5} and 'long' gauge field strength operators

    SciTech Connect (OSTI)

    Park, I.Y.; Tirziu, A.; Tseytlin, A.A.

    2005-06-15

    We consider circular strings rotating with equal spins S{sub 1}=S{sub 2}=S in two orthogonal planes in AdS{sub 5} and suggest that they may be dual to long gauge-theory operators built out of self-dual components of gauge field strength. As was found in hep-th/0404187, the one-loop anomalous dimensions of the such gauge-theory operators are described by an antiferromagnetic XXX{sub 1} spin chain and scale linearly with length L>>1. We find that in the case of rigid rotating string both the classical energy E{sub 0} and the 1-loop string correction E{sub 1} depend linearly on the spin S (within the stability region of the solution). This supports the identification of the rigid rotating string with the gauge-theory operator corresponding to the maximal-spin (ferromagnetic) state of the XXX{sub 1} spin chain. The energy of more general rotating and pulsating strings also happens to scale linearly with both the spin and the oscillation number. Such solutions should be dual to other lower-spin states of the spin chain, with the antiferromagnetic ground state presumably corresponding to the string pulsating in two planes with no rotation.

  3. Docket # EERE-2014-BT-STD-0051, and/or RIN 1904-AD40 Ex Parte Meeting 24th

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    February 2015 | Department of Energy 4-BT-STD-0051, and/or RIN 1904-AD40 Ex Parte Meeting 24th February 2015 Docket # EERE-2014-BT-STD-0051, and/or RIN 1904-AD40 Ex Parte Meeting 24th February 2015 Thanks for the invitation to discuss and explain comments to a new proposed gas compressor efficiency standard. DoE GasCompressors Efficiency HOERBIGER 9-1-2015 AdditionalResponse (83.97 KB) More Documents & Publications Natural Gas Infrastructure R&D and Methane Emissions Mitigation

  4. ARM Climate Research Facility Quarterly Value-Added Product Report January 1‚ÄďMarch 30, 2011

    SciTech Connect (OSTI)

    Sivaraman, C

    2011-06-14

    The purpose of this report is to provide a concise status update for value-added products (VAP) implemented by the Atmospheric Radiation Measurement Climate Research Facility. The report is divided into the following sections: (1) new VAPs for which development has begun, (2) progress on existing VAPs, and (3) future VAPs that have been recently approved.

  5. Strings on AdS wormholes

    SciTech Connect (OSTI)

    Ali, Mir; Ruiz, Frenny; Saint-Victor, Carlos; Vazquez-Poritz, Justin F.

    2009-08-15

    We consider the behavior of open strings on anti-de Sitter wormholes in Gauss-Bonnet theory, which are the Gauss-Bonnet gravity duals of a pair of field theories. A string with both endpoints on the same side of the wormhole describes two charges within the same field theory, which exhibit Coulomb interaction for small separation. On the other hand, a string extending through the wormhole describes two charges which live in different field theories, and they exhibit a springlike confining potential. A transition occurs when there is a pair of charges present within each field theory: for small separation each pair of charges exhibits Coulomb interaction, while for large separation the charges in the different field theories pair up and exhibit confinement. Two steadily-moving charges in different field theories can occupy the same location provided that their speed is less than a critical speed, which also plays the role of a subluminal speed limit. However, for some wormhole backgrounds, charges moving at the critical speed cannot occupy the same location and energy is transferred from the leading charge to the lagging one. We also show that strings on anti-de Sitter wormholes in supergravity theories without higher-derivative curvature terms can exhibit these properties as well.

  6. Effect of unmodulated laser light on the nanostructure of a thin solid AD-1 azo dye film

    SciTech Connect (OSTI)

    Dubrovkin, A M; Ezhov, A A; Kozenkov, V M; Magnitskiy, Sergey A; Nagorskiy, Nikolay M; Panov, Vladimir I

    2010-06-23

    Exposure to light uniform in intensity and polarisation causes marked changes in the surface topography of a thin (320 nm) nanostructured AD-1 low molecular weight azo dye film. Linearly polarised incoherent light with a wavelength of 470 nm and intensity of 1 mW cm{sup -2} produces numerous teardrop-shaped hillocks of the order of 200 nm in radius over most of the film surface. (letters)

  7. Top Value Added Chemicals from Biomass: Volume I--Results of Screening for Potential Candidates from Sugars and Synthesis Gas

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Top Value Added Chemicals from Biomass Volume I-Results of Screening for Potential Candidates from Sugars and Synthesis Gas Produced by the Staff at Pacific Northwest National Laboratory (PNNL) National Renewable Energy Laboratory (NREL) Office of Biomass Program (EERE) For the Office of the Biomass Program T. Werpy and G. Petersen, Editors U.S. Department of Energy Energy Efficiency and Renewable Energy Bringing you a prosperous future where energy is clean, abundant, reliable, and affordable

  8. DOE/SC-ARM/TR-095 The Microbase Value-Added Product: A Baseline Retrieval of Cloud

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    5 The Microbase Value-Added Product: A Baseline Retrieval of Cloud Microphysical Properties M Dunn K Johnson M Jensen May 2011 DISCLAIMER This report was prepared as an account of work sponsored by the U.S. Government. Neither the United States nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or

  9. ARM Climate Research Facility Quarterly Value-Added Product Report First Quarter: October 01-December 31, 2011

    SciTech Connect (OSTI)

    Sivaraman, C

    2012-02-28

    The purpose of this report is to provide a concise status update for value-added products (VAP) implemented by the Atmospheric Radiation Measurement (ARM) Climate Research Facility. The report is divided into the following sections: (1) new VAPs for which development has begun, (2) progress on existing VAPs, (3) future VAPs that have been recently approved, (4) other work that leads to a VAP, and (5) top requested VAPs from the archive.

  10. ARM Climate Research Facility Quarterly Value-Added Product Report Fourth Quarter: July 1‚ÄďSeptember 30, 2012

    SciTech Connect (OSTI)

    Sivaraman, C

    2012-11-13

    The purpose of this report is to provide a concise status update for value-added products (VAP) implemented by the Atmospheric Radiation Measurement (ARM) Climate Research Facility. The report is divided into the following sections: (1) new VAPs for which development has begun, (2) progress on existing VAPs, (3) future VAPs that have been recently approved, (4) other work that leads to a VAP, and (5) top requested VAPs from the archive.

  11. ARM Climate Research Facility Quarterly Value-Added Product Report Third Quarter: April 01‚ÄďJune 30, 2011

    SciTech Connect (OSTI)

    Sivaraman, C

    2011-08-18

    The purpose of this report is to provide a concise status update for value-added products (VAP) implemented by the Atmospheric Radiation Measurement Climate Research Facility. The report is divided into the following sections: (1) new VAPs for which development has begun, (2) progress on existing VAPs, (3) future VAPs that have been recently approved, (4) other work that leads to a VAP, and (5) top requested VAPs from the archive

  12. Chapter 4: Advancing Clean Electric Power Technologies | Carbon Dioxide and Storage Value-Added Options Technology Assessment

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Storage Value-Added Options Carbon Dioxide Capture for Natural Gas and Industrial Applications Carbon Dioxide Capture Technologies Carbon Dioxide Storage Technologies Crosscutting Technologies in Carbon Dioxide Capture and Storage Fast-spectrum Reactors Geothermal Power High Temperature Reactors Hybrid Nuclear-Renewable Energy Systems Hydropower Light Water Reactors Marine and Hydrokinetic Power Nuclear Fuel Cycles Solar Power Stationary Fuel Cells Supercritical Carbon Dioxide Brayton Cycle

  13. Possible mechanisms for arsenic-induced proliferative diseases

    SciTech Connect (OSTI)

    Wetterhahn, K.E.; Dudek, E.J.; Shumilla, J.A.

    1996-12-31

    Possible mechanisms for cardiovascular diseases and cancers which have been observed on chronic exposure to arsenic have been investigated. We tested the hypothesis that nonlethal levels of arsenic are mitogenic, cause oxidative stress, increase nuclear translocation of trans-acting factors, and increase expression of genes involved in proliferation. Cultured porcine vascular (from aorta) endothelial cells were used as a model cell system to study the effects of arsenic on the target cells for cardiovascular diseases. Treatment of postconfluent cell cultures with nonovertly toxic concentrations of arsenite increased DNA synthesis, similar to the mitogenic response observed with hydrogen peroxide. Within 1 hour of adding noncytotoxic concentrations of arsenite, cellular levels of oxidants increased relative to control levels, indicating that arsenite promotes cellular oxidations. Arsenite treatment increased nuclear translocation of NF-{kappa}B, an oxidative stress-responsive transcription factor, in a manner similar to that observed with hydrogen peroxide. Pretreatment of intact cells with the antioxidants N-acetylcysteine and dimethylfumarate prevented the arsenite-induced increases in cellular oxidant formation and NF-KB translocation. Arsenite had little or no effect on binding of NF-KB to its DNA recognition sequence in vitro, indicating that it is unlikely that arsenite directly affects NF-KB. The steady-state mRNA levels of intracellular adhesion molecule and urokinase-like plasminogen activator, genes associated with the active endothelial phenotype in arteriosclerosis and cancer metastasis, were increased by nontoxic concentrations of arsenite. These data suggest that arsenite promotes proliferative diseases like heart disease and cancer by activating oxidant-sensitive endothelial cell signaling and gene expression. It is possible that antioxidant therapy would be useful in preventing arsenic-induced cardiovascular disease and cancer.

  14. OSTIblog Articles in the disease Topic | OSTI, US Dept of Energy...

    Office of Scientific and Technical Information (OSTI)

    John Q. Trojanowski, an Alzheimer's researcher at the University of Pennsylvania, "It's not science the way most of us have practiced it in our careers. But we all realized that we ...

  15. Adding Erlotinib to Chemoradiation Improves Overall Survival but Not Progression-Free Survival in Stage III Non-Small Cell Lung Cancer

    SciTech Connect (OSTI)

    Komaki, Ritsuko; Allen, Pamela K.; Wei, Xiong; Blumenschein, George R.; Tang, Ximing; Lee, J. Jack; Welsh, James W.; Wistuba, Ignacio I.; Liu, Diane D.; Hong, Waun Ki

    2015-06-01

    Purpose: To test, in a single-arm, prospective, phase 2 trial, whether adding the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib to concurrent chemoradiotherapy for previously untreated, locally advanced, inoperable non-small cell lung¬†cancer would improve survival and disease control without increasing toxicity. Methods and Materials: Forty-eight patients with previously untreated non-small cell lung cancer received intensity modulated radiation therapy (63¬†Gy/35 fractions) on Monday through Friday, with chemotherapy (paclitaxel 45¬†mg/m¬≤, carboplatin area under the curve [AUC] = 2) on Mondays, for 7¬†weeks. All patients also received the EGFR tyrosine kinase inhibitor erlotinib (150¬†mg orally 1/d) on Tuesday-Sunday for 7¬†weeks, followed by consolidation paclitaxel‚Äďcarboplatin. The primary endpoint was time to progression; secondary endpoints were overall survival (OS), toxicity, response, and disease control and whether any endpoint differed by EGFR mutation status. Results: Of 46 patients evaluable for response, 40 were former or never-smokers, and 41 were evaluable for EGFR mutations (37 wild-type [WT] and 4 mutated [all adenocarcinoma]). Median time to progression was 14.0¬†months and did not differ by EGFR status. Toxicity was acceptable (no grade 5, 1 grade 4, 11 grade 3). Twelve patients (26%) had complete responses (10 WT, 2 mutated), 27 (59%) partial (21 WT, 2 mutated, 4 unknown), and 7 (15%) none (6 WT, 2 mutated, 1 unknown) (P=.610). At 37.0¬†months' follow-up (range, 3.6-76.5¬†months) for all patients, median OS time was 36.5¬†months, and 1-, 2-, and 5-year OS rates were 82.6%, 67.4%, and 35.9%, respectively; none differed by mutation status. Twelve patients had no progression, and 34 had local and/or distant failure. Eleven of 27 distant failures were in the brain (7 WT, 3 mutated, 1 unknown). Conclusions: Toxicity and OS were promising, but time to progression did not meet expectations. The prevalence of distant

  16. Atomic-resolution 3D structure of amyloid ő≤ fibrils: The Osaka mutation

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Schutz, Anne K.; Wall, Joseph; Vagt, Toni; Huber, Matthias; Ovchinnikova, Oxana Y.; Cadalbert, Riccardo; Guntert, Peter; Bockmann, Anja; Glockshuber, Rudi; Meier, Beat H.

    2014-11-13

    Despite its central importance for understanding the molecular basis of Alzheimer's disease (AD), high-resolution structural information on amyloid ő≤-peptide (Aő≤) fibrils, which are intimately linked with AD, is scarce. We report an atomic-resolution fibril structure of the Aő≤ 1-40 peptide with the Osaka mutation (E22őĒ), associated with early-onset AD. The structure, which differs substantially from all previously proposed models, is based on a large number of unambiguous intra- and intermolecular solid-state NMR distance restraints

  17. Atomic-resolution 3D structure of amyloid ? fibrils: The Osaka mutation

    SciTech Connect (OSTI)

    Schutz, Anne K.; Wall, Joseph; Vagt, Toni; Huber, Matthias; Ovchinnikova, Oxana Y.; Cadalbert, Riccardo; Guntert, Peter; Bockmann, Anja; Glockshuber, Rudi; Meier, Beat H.

    2014-11-13

    Despite its central importance for understanding the molecular basis of Alzheimer's disease (AD), high-resolution structural information on amyloid ?-peptide (A?) fibrils, which are intimately linked with AD, is scarce. We report an atomic-resolution fibril structure of the A? 1-40 peptide with the Osaka mutation (E22?), associated with early-onset AD. The structure, which differs substantially from all previously proposed models, is based on a large number of unambiguous intra- and intermolecular solid-state NMR distance restraints

  18. Investigating the Influence of the Added Mass Effect to Marine Hydrokinetic Horizontal-Axis Turbines Using a General Dynamic Wake Wind Turbine Code: Preprint

    SciTech Connect (OSTI)

    Maniaci, D. C.; Li, Y.

    2012-04-01

    This paper describes a recent study to investigate the applicability of a horizontal-axis wind turbine (HAWT) structural dynamics and unsteady aerodynamics analysis program (FAST and AeroDyn respectively) to modeling the forces on marine hydrokinetic (MHK) turbines. It summarizes the added mass model that has been added to AeroDyn. The added mass model only includes flow acceleration perpendicular to the rotor disc, and ignores added mass forces caused by blade deflection. A model of the National Renewable Energy Laboratory's (NREL) Unsteady Aerodynamics Experiment (UAE) Phase VI wind turbine was analyzed using FAST and AeroDyn with sea water conditions and the new added mass model. The results of this analysis exhibited a 3.6% change in thrust for a rapid pitch case and a slight change in amplitude and phase of thrust for a case with 30 degrees of yaw.

  19. Investigating the Influence of the Added Mass Effect to Marine Hydrokinetic Horizontal-Axis Turbines Using a General Dynamic Wake Wind Turbine Code

    SciTech Connect (OSTI)

    Maniaci, D. C.; Li, Y.

    2011-10-01

    This paper describes a recent study to investigate the applicability of a horizontal-axis wind turbine (HAWT) structural dynamics and unsteady aerodynamics analysis program (FAST and AeroDyn respectively) to modeling the forces on marine hydrokinetic (MHK) turbines. This paper summarizes the added mass model that has been added to AeroDyn. The added mass model only includes flow acceleration perpendicular to the rotor disc, and ignores added mass forces caused by blade deflection. A model of the National Renewable Energy Laboratory's (NREL) Unsteady Aerodynamics Experiment (UAE) Phase VI wind turbine was analyzed using FAST and AeroDyn with sea water conditions and the new added mass model. The results of this analysis exhibited a 3.6% change in thrust for a rapid pitch case and a slight change in amplitude and phase of thrust for a case with 30{sup o} of yaw.

  20. Early detection of contagious diseases

    DOE Patents [OSTI]

    Colston, Jr., Billy W.; Milanovich, Fred P.; Estacio, Pedro; Chang, John

    2011-08-09

    This invention provides an electronic proximity apparatus and a surveillance method using such an apparatus for alerting individuals that are exposed to a contagious disease. When a person becomes symptomatic and is diagnosed as positive for a given contagious agent, individuals that have recently maintained a threshold proximity with respect to an infected individual are notified and advised to seek immediate medial care. Treatment of individuals in the very early phases of infection (pre-symptomatic) significantly reduces contagiousness of the infected population first exposed to the contagious disease, thus preventing spread of the disease throughout the general population.

  1. No-carrier-added (NCA) aryl (18E) fluorides via the nucleophilic aromatic substitution of electron rich aromatic rings

    DOE Patents [OSTI]

    Ding, Yu-Shin; Fowler, Joanna S.; Wolf, Alfred P.

    1993-01-01

    A method for synthesizing no-carrier-added (NCA) aryl [.sup.18 F] fluoride substituted aromatic aldehyde compositions bearing an electron donating group is described. The method of the present invention includes the step of reacting aromatic nitro aldehydes having a suitably protected hydroxyl substitutent on an electron rich ring. The reaction is The U.S. Government has rights in this invention pursuant to Contract Number DE-AC02-76CH00016, between the U.S. Department of Energy and Associated Universities Inc.

  2. No-carrier-added (NCA) aryl ([sup 18]F) fluorides via the nucleophilic aromatic substitution of electron rich aromatic rings

    DOE Patents [OSTI]

    Yushin Ding; Fowler, J.S.; Wolf, A.P.

    1993-10-19

    A method for synthesizing no-carrier-added (NCA) aryl [.sup.18 F] fluoride substituted aromatic aldehyde compositions bearing an electron donating group is described. The method of the present invention includes the step of reacting aromatic nitro aldehydes having a suitably protected hydroxyl substitutent on an electron rich ring. The reaction is The U.S. Government has rights in this invention pursuant to Contract Number DE-AC02-76CH00016, between the U.S. Department of Energy and Associated Universities Inc.

  3. Top Value-Added Chemicals from Biomass - Volume II¬ĄResults of Screening for Potential Candidates from Biorefinery Lignin

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Top Value-Added Chemicals from Biomass Volume II-Results of Screening for Potential Candidates from Biorefinery Lignin 1 JE Holladay 2 JJ Bozell 1 JF White 3 D Johnson 1 Pacific Northwest National Laboratory 2 University of Tennessee 3 National Renewable Energy Laboratory October 2007 Prepared for the U.S. Department of Energy under Contract DE-AC05-76RL01830 PNNL-16983 DISCLAIMER This report was prepared as an account of work sponsored by an agency of the United States Government. Neither the

  4. DOE/SC-ARM/P-07-005.1 ARM Value-Added Product (VAP) Monthly Status Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    1 ARM Value-Added Product (VAP) Monthly Status Report ARM Translator Team J. Comstock C. Flynn M. Jensen C. Long D. Turner S. Xie March 13, 2007 Work supported by the U.S. Department of Energy, Office of Science, Office of Biological and Environmental Research DISCLAIMER This report was prepared as an account of work sponsored by the U.S. Government. Neither the United States nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal

  5. ARM Climate Research Facility Quarterly Value-Added Product Report Fourth Quarter: July 01‚ÄďSeptember 30, 2011

    SciTech Connect (OSTI)

    Sivaraman, C

    2011-11-02

    The purpose of this report is to provide a concise status update for value-added products (VAP) implemented by the Atmospheric Radiation Measurement Climate Research Facility. The report is divided into the following sections: (1) new VAPs for which development has begun, (2) progress on existing VAPs, (3) future VAPs that have been recently approved, (4) other work that leads to a VAP, and (5) top requested VAPs from the archive. New information is highlighted in blue text. New information about processed data by the developer is highlighted in red text.

  6. On N = 2 compactifications of M-theory to AdS{sub 3} using geometric algebra techniques

    SciTech Connect (OSTI)

    Babalic, E. M.; Coman, I. A.; Condeescu, C.; Micu, A.; Lazaroiu, C. I.

    2013-11-13

    We investigate the most general warped compactification of eleven-dimensional supergravity on eight-dimensional manifolds to AdS{sub 3} spaces (in the presence of non-vanishing four-form flux) which preserves N = 2 supersymmetry in three dimensions. Without imposing any restrictions on the chirality of the internal part of the supersymmetry generators, we use geometric algebra techniques to study some implications of the supersymmetry constraints. In particular, we discuss the Lie bracket of certain vector fields constructed as pinor bilinears on the compactification manifold.

  7. The Y-12 Plant No Rad-Added Program for off-site shipment of nonradioactive hazardous waste

    SciTech Connect (OSTI)

    Cooper, K.H.; Mattie, B.K.; Williams, J.L.; Jacobs, D.G.; Roberts, K.A.

    1994-02-14

    On May 17, 1991, the US Department of Energy (DOE) issued a directive for DOE operations to cease off-site shipments of non-radioactive hazardous waste pending further clarification and approvals. A DOE Performance Objective for Certification of Non-Radioactive Hazardous Waste was issued in November 1991. In response to these directives, the Waste Management Division of Oak Ridge Y-12 Plant, with assistance from Roy F. Weston, Inc., has developed a No Rad-Added Program to provide small programmatic guidance and a set of procedures, approved by DOE, which will permit hazardous waste to be shipped from the Y-12 Plant to commercial treatment, storage, or disposal facilities after ensuring and certifying that hazardous waste has no radioactivity added as a result of DOE operations. There are serious legal and financial consequences of shipping waste containing radioactivity to an off-site facility not licensed to receive radioactive materials. Therefore, this program is designed with well-defined responsibilities and stringent documentation requirements.

  8. Broad Temperature Pinning Study of 15 mol.% Zr-Added (Gd, Y)-Ba-Cu-O MOCVD Coated Conductors

    SciTech Connect (OSTI)

    Xu, AX; Khatri, N; Liu, YH; Majkic, G; Galstyan, E; Selvamanickam, V; Chen, YM; Lei, CH; Abraimov, D; Hu, XB; Jaroszynski, J; Larbalestier, D

    2015-06-01

    BaZrO3 (BZO) nanocolumns have long been shown to be very effective for raising the pinning force F-p of REBa2Cu3Ox (REBCO, where RE = rare earth) films at high temperatures and recently at low temperatures too. We have successfully incorporated a high density of BZO nanorods into metal organic chemical vapor deposited (MOCVD) REBCO coated conductors via Zr addition. We found that, compared to the 7.5% Zr-added coated conductor, dense BZO nanorod arrays in the 15% Zr-added conductor are effective over the whole temperature range from 77 K down to 4.2 K. We attribute the substantially enhanced J(c) at 30 K to the weak uncorrelated pinning as well as the strong correlated pinning. Meanwhile, by tripling the REBCO layer thickness to similar to 2.8 mu m, the engineering critical current density J(e) at 30 K exceeds J(e) of optimized Nb-Ti wires at 4.2 K.

  9. Microalgae as a feedstock for biofuel precursors and value-added products: Green fuels and golden opportunities

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Tang, Yuting; Rosenberg, Julian N.; Bohutskyi, Pavlo; Yu, Geng; Betenbaugh, Michael J.; Wang, Fei

    2015-11-16

    In this study, the prospects of biofuel production from microalgal carbohydrates and lipids coupled with greenhouse gas mitigation due to photosynthetic assimilation of CO2 have ushered in a renewed interest in algal feedstock. Furthermore, microalgae (including cyanobacteria) have become established as commercial sources of value-added biochemicals such as polyunsaturated fatty acids and carotenoid pigments used as antioxidants in nutritional supplements and cosmetics. This article presents a comprehensive synopsis of the metabolic basis for accumulating lipids as well as applicable methods of lipid and cellulose bioconversion and final applications of these natural or refined products from microalgal biomass. For lipids, one-stepmore¬†¬Ľ in situ transesterification offers a new and more accurate approach to quantify oil content. As a complement to microalgal oil fractions, the utilization of cellulosic biomass from microalgae to produce bioethanol by fermentation, biogas by anaerobic digestion, and bio-oil by hydrothermal liquefaction are discussed. Collectively, a compendium of information spanning green renewable fuels and value-added nutritional compounds is provided.¬ę¬†less

  10. Microalgae as a feedstock for biofuel precursors and value-added products: Green fuels and golden opportunities

    SciTech Connect (OSTI)

    Tang, Yuting; Rosenberg, Julian N.; Bohutskyi, Pavlo; Yu, Geng; Betenbaugh, Michael J.; Wang, Fei

    2015-11-16

    In this study, the prospects of biofuel production from microalgal carbohydrates and lipids coupled with greenhouse gas mitigation due to photosynthetic assimilation of CO2 have ushered in a renewed interest in algal feedstock. Furthermore, microalgae (including cyanobacteria) have become established as commercial sources of value-added biochemicals such as polyunsaturated fatty acids and carotenoid pigments used as antioxidants in nutritional supplements and cosmetics. This article presents a comprehensive synopsis of the metabolic basis for accumulating lipids as well as applicable methods of lipid and cellulose bioconversion and final applications of these natural or refined products from microalgal biomass. For lipids, one-step in situ transesterification offers a new and more accurate approach to quantify oil content. As a complement to microalgal oil fractions, the utilization of cellulosic biomass from microalgae to produce bioethanol by fermentation, biogas by anaerobic digestion, and bio-oil by hydrothermal liquefaction are discussed. Collectively, a compendium of information spanning green renewable fuels and value-added nutritional compounds is provided.

  11. Data:5277c4c2-0b8b-4179-ad2c-59139826c6f2 | Open Energy Information

    Open Energy Info (EERE)

    ad2c-59139826c6f2 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic...

  12. Data:9f33a9f9-21ad-47b2-9b1f-4b3771f914ac | Open Energy Information

    Open Energy Info (EERE)

    ad-47b2-9b1f-4b3771f914ac No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic...

  13. Preclinical pharmacology and toxicology study of Ad-hTERT-E1a-Apoptin, a novel dual cancer-specific oncolytic adenovirus

    SciTech Connect (OSTI)

    Qi, Yanxin; Guo, Huanhuan; Hu, Ningning; He, Dongyun; Zhang, Shi; Chu, Yunjie; Huang, Yubin; Li, Xiao; Sun, LiLi; Jin, Ningyi

    2014-10-15

    Clinical studies have demonstrated that conditionally replicating adenovirus is safe. We constructed an oncolytic adenovirus, Ad-hTERT-E1a-Apoptin, using a cancer-specific promoter (human telomerase reverse transcriptase promoter, hTERTp) and a cancer cell-selective apoptosis-inducing gene (Apoptin). Ad-hTERT-E1a-Apoptin was proven effective both in vitro and in vivo in our previous study. In this study, the preclinical safety profiles of Ad-hTERT-E1a-Apoptin in animal models were investigated. At doses of 5.0 √ó 10{sup 8}, 2.5 √ó 10{sup 9}, and 1.25 √ó 10{sup 10} viral particles (VP)/kg, Ad-hTERT-E1a-Apoptin had no adverse effects on mouse behavior, muscle cooperation, sedative effect, digestive system, and nervous systems, or on beagle cardiovascular and respiratory systems at 5.0 √ó 10{sup 8}, 2.5 √ó 10{sup 9}, and 1.25 √ó 10{sup 10} VP/kg doses. In acute toxicity tests in mice, the maximum tolerated dose > 5 √ó 10{sup 10} VP/kg. There was no inflammation or ulceration at the injection sites within two weeks. In repeat-dose toxicological studies, the no observable adverse effect levels of Ad-hTERT-E1a-Apoptin in rats (1.25 √ó 10{sup 10} VP/kg) and beagles (2.5 √ó 10{sup 9} VP/kg) were 62.5- and 12.5-fold of the proposed clinical dose, respectively. The anti-virus antibody was produced in animal sera. Bone marrow examination revealed no histopathological changes. Guinea pigs sensitized by three repeated intraperitoneal injections of 1.35 √ó 10{sup 10} VP/mL Ad-hTERT-E1a-Apoptin each and challenged by one intravenous injection of 1.67 √ó 10{sup 8} VP/kg Ad-hTERT-E1a-Apoptin did not exhibit any sign of systemic anaphylaxis. Our data from different animal models suggest that Ad-hTERT-E1a-Apoptin is a safe anti-tumor therapeutic agent. - Highlights: ‚ÄĘ We use the rodents and non-rodents animal models to evaluation Ad-hTERT-E1a-Apoptin. ‚ÄĘ Ad-hTERT-E1a-Apoptin is a safe anti-tumor therapeutic agent. ‚ÄĘ Demonstrate the safety and feasibility dose of injected Ad

  14. Poster_AD.ppt

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    radiative transfer (RT) model with an unconventional propagation kernel, i.e., the term in ... Barker, H. W., B. A. Wielicki, and L. Parker, 1996: A parameterization for computing ...

  15. Del Genio-AD

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Simulated Vertical Structure of Tropical Convective Storms: Implications for GCM Parameterization A. D. Del Genio National Aeronautics and Space Administration Goddard Institute for Space Studies New York Introduction General circulation model (GCM) simulations of equilibrium greenhouse gas-induced climate change suggest that the single largest contributor to uncertainty in cloud feedback is due to changes in the areal extent and cloud water contents (CWC) of mesoscale convective systems (Yao

  16. Adding New Functionality

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    If an error dialog box appears, try logging in again. Contact Kelle Smith at kelle.smith@pnl.gov if you need assistance. Readiness Review Requests Pre-Deployment Readiness Review...

  17. Power production and ADS

    SciTech Connect (OSTI)

    Raja, Rajendran; /Fermilab

    2010-03-01

    We describe the power production process in Accelerator Driven Sub-critical systems employing Thorium-232 and Uranium-238 as fuel and examine the demands on the power of the accelerator required.

  18. 201008ad.cdr

    Office of Legacy Management (LM)

    Environmental Assessment for a Proposed Solar Energy Project near Durango The U.S. ... related to installing a photovoltaic solar electrical-generation system of ...

  19. 201004ad.cdr

    Office of Legacy Management (LM)

    Public to Attend Public Scoping Meeting on Proposed Solar Energy Project Near Durango U.S. ... related to installing a photovoltaic solar electrical generation system of up to 4.5 ...

  20. Patching genes to fight disease

    SciTech Connect (OSTI)

    Holzman, D.

    1990-09-03

    The National Institutes of Health has approved the first gene therapy experiments, one of which will try to cure cancer by bolstering the immune system. The applications of such therapy are limited, but the potential aid to people with genetic diseases is great.

  1. Etiology of gas bubble disease

    SciTech Connect (OSTI)

    Bouck, G.R.

    1980-11-01

    Gas bubble disease is a noninfectious, physically induced process caused by uncompensated hyperbaric pressure of total dissolved gases. When pressure compensation is inadequate, dissolved gases may form emboli (in blood) and emphysema (in tissues). The resulting abnormal physical presence of gases can block blood vessels (hemostasis) or tear tissues, and may result in death. Population mortality is generally skewed, in that the median time to death occurs well before the average time to death. Judged from mortality curves, three stages occur in gas bubble disease: (1) a period of gas pressure equilibrium, nonlethal cavitation, and increasing morbidity; (2) a period of rapid and heavy mortality; and (3) a period of protracted survival, despite lesions, and dysfunction that eventually terminates in total mortality. Safe limits for gas supersaturation depend on species tolerance and on factors that differ among hatcheries and rivers, between continuous and intermittent exposures, and across ranges of temperature and salinity.

  2. Extended Virtual Spring Mesh (EVSM): The Distributed Self-Organizing Mobile Ad Hoc Network for Area Exploration

    SciTech Connect (OSTI)

    Kurt Derr

    2011-12-01

    Mobile Ad hoc NETworks (MANETs) are distributed self-organizing networks that can change locations and configure themselves on the fly. This paper focuses on an algorithmic approach for the deployment of a MANET within an enclosed area, such as a building in a disaster scenario, which can provide a robust communication infrastructure for search and rescue operations. While a virtual spring mesh (VSM) algorithm provides scalable, self-organizing, and fault-tolerant capabilities required by aMANET, the VSM lacks the MANET's capabilities of deployment mechanisms for blanket coverage of an area and does not provide an obstacle avoidance mechanism. This paper presents a new technique, an extended VSM (EVSM) algorithm that provides the following novelties: (1) new control laws for exploration and expansion to provide blanket coverage, (2) virtual adaptive springs enabling the mesh to expand as necessary, (3) adapts to communications disturbances by varying the density and movement of mobile nodes, and (4) new metrics to assess the performance of the EVSM algorithm. Simulation results show that EVSM provides up to 16% more coverage and is 3.5 times faster than VSM in environments with eight obstacles.

  3. Canonical and kinetic forms of the electromagnetic momentum in an ad hoc quantization scheme for a dispersive dielectric

    SciTech Connect (OSTI)

    Garrison, J.C.; Chiao, R.Y.

    2004-11-01

    An ad hoc quantization scheme for the electromagnetic field in a weakly dispersive, transparent dielectric leads to the definition of canonical and kinetic forms for the momentum of the electromagnetic field in a dispersive medium. The canonical momentum is uniquely defined as the operator that generates spatial translations in a uniform medium, but the quantization scheme suggests two possible choices for the kinetic momentum operator, corresponding to the Abraham or the Minkowski momentum in classical electrodynamics. Another implication of this procedure is that a wave packet containing a single dressed photon travels at the group velocity through the medium. The physical significance of the canonical momentum has already been established by considerations of energy and momentum conservation in the atomic recoil due to spontaneous emission, the Cerenkov effect, the Doppler effect, and phase matching in nonlinear optical processes. In addition, the data of the Jones and Leslie radiation pressure experiment is consistent with the assignment of one ({Dirac_h}/2{pi})k unit of canonical momentum to each dressed photon. By contrast, experiments in which the dielectric is rigidly accelerated by unbalanced electromagnetic forces require the use of the Abraham momentum.

  4. Luminescence and electrical properties of solution-processed ZnO thin films by adding fluorides and annealing atmosphere

    SciTech Connect (OSTI)

    Choi, Sungho; Park, Byung-Yoon; Jung, Ha-Kyun

    2011-06-15

    Highlights: {yields} Systematic study of the fluorides doped solution-processed ZnO thin films via the luminescence and electrical behaviors. {yields} Defect-related visible emission bands are affected by annealing ambient and fluoride addition. {yields} Adding lithium fluoride followed by annealing in oxygen ambient leads to a controlled defect density with proper TFT performance. -- Abstract: To develop an efficient channel layer for thin film transistors (TFTs), understanding the defect-related luminescence and electrical property is crucial for solution-processed ZnO thin films. Film growth with the fluorides addition, especially using LiF, followed by the oxygen ambient post-annealing leads to decreased defect-related emission as well as enhanced switching property. The saturation mobility and current on/off ratio are 0.31 cm{sup 2} V{sup -1} s{sup -1} and 1.04 x 10{sup 3}. Consequently, we can visualize an optimized process condition and characterization method for solution-processed TFT based on the fluorine-doped ZnO film channel layer by considering the overall emission behavior.

  5. A simple technique to reduce evaporation of crystallization droplets by using plate lids with apertures for adding liquids

    SciTech Connect (OSTI)

    Zipper, Lauren E.; Aristide, Xavier; Bishop, Dylan P.; Joshi, Ishita; Kharzeev, Julia; Patel, Krishna B.; Santiago, Brianna M.; Joshi, Karan; Dorsinvil, Kahille; Sweet, Robert M.; Soares, Alexei S.

    2014-11-28

    A method is described for using plate lids to reduce evaporation in low-volume vapor-diffusion crystallization experiments. The plate lids contain apertures through which the protein and precipitants were added to different crystallization microplates (the reservoir was filled before fitting the lids). Plate lids were designed for each of these commonly used crystallization microplates. This system minimizes the dehydration of crystallization droplets containing just a few nanolitres of protein and precipitant, and results in more reproducible diffraction from the crystals. For each lid design, changes in the weight of the plates were used to deduce the rate of evaporation under different conditions of temperature, air movement, droplet size and precipitant. For comparison, the state of dehydration was also visually assessed throughout the experiment. Finally, X-ray diffraction methods were used to compare the diffraction of protein crystals that were conventionally prepared against those that were prepared on plates with plate lids. The measurements revealed that the plate lids reduced the rate of evaporation by 63‚Äď82%. Crystals grown in 5 nl drops that were set up with plate lids diffracted to higher resolution than similar crystals from drops that were set up without plate lids. Ultimately, the results demonstrate that plate lids can be instrumental for improving few-nanolitre crystallizations.

  6. A simple technique to reduce evaporation of crystallization droplets by using plate lids with apertures for adding liquids

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Zipper, Lauren E.; Aristide, Xavier; Bishop, Dylan P.; Joshi, Ishita; Kharzeev, Julia; Patel, Krishna B.; Santiago, Brianna M.; Joshi, Karan; Dorsinvil, Kahille; Sweet, Robert M.; et al

    2014-11-28

    A method is described for using plate lids to reduce evaporation in low-volume vapor-diffusion crystallization experiments. The plate lids contain apertures through which the protein and precipitants were added to different crystallization microplates (the reservoir was filled before fitting the lids). Plate lids were designed for each of these commonly used crystallization microplates. This system minimizes the dehydration of crystallization droplets containing just a few nanolitres of protein and precipitant, and results in more reproducible diffraction from the crystals. For each lid design, changes in the weight of the plates were used to deduce the rate of evaporation under differentmore¬†¬Ľ conditions of temperature, air movement, droplet size and precipitant. For comparison, the state of dehydration was also visually assessed throughout the experiment. Finally, X-ray diffraction methods were used to compare the diffraction of protein crystals that were conventionally prepared against those that were prepared on plates with plate lids. The measurements revealed that the plate lids reduced the rate of evaporation by 63‚Äď82%. Crystals grown in 5 nl drops that were set up with plate lids diffracted to higher resolution than similar crystals from drops that were set up without plate lids. Ultimately, the results demonstrate that plate lids can be instrumental for improving few-nanolitre crystallizations.¬ę¬†less

  7. RNA simulations boost understanding of retroviral diseases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    RNA simulations boost understanding of retroviral diseases RNA simulations boost understanding of retroviral diseases New molecular dynamics research into how RNA folds into hairpin-shaped structures called tetraloops could provide important insights into new treatments for retroviral diseases. May 31, 2016 An example of RNA folded into a tetraloop, in this case the "Z-form duplex" under study that could provide medical treatment opportunities for retroviral diseases such as Zika and

  8. Protein Instability and Lou Gehrig's Disease

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protein Instability and Lou Gehrig's Disease Protein Instability and Lou Gehrig's Disease Print Wednesday, 25 March 2015 00:00 A new study links protein instability with the progression of a lethal degenerative disease: amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. Using several biophysical techniques as well as small-angle x-ray scattering (SAXS) at the Advanced Light Source, researchers focused on the effects of mutations to a gene coding for a protein called

  9. Computational and experimental study of the effects of adding dimethyl ether and ethanol to nonpremixed ethylene/air flames

    SciTech Connect (OSTI)

    Bennett, Beth Anne V.; McEnally, Charles S.; Pfefferle, Lisa D.; Smooke, Mitchell D.; Colket, Meredith B.

    2009-06-15

    Two sets of axisymmetric laminar coflow flames, each consisting of ethylene/air nonpremixed flames with various amounts (up to 10%) of either dimethyl ether (CH{sub 3}-O-CH{sub 3}) or ethanol (CH{sub 3}-CH{sub 2}-OH) added to the fuel stream, have been examined both computationally and experimentally. Computationally, the local rectangular refinement method, which incorporates Newton's method, is used to solve the fully coupled nonlinear conservation equations on solution-adaptive grids for each flame in two spatial dimensions. The numerical model includes C6 chemical kinetic mechanisms with up to 59 species, detailed transport, and an optically thin radiation submodel. Experimentally, thermocouples are used to measure gas temperatures, and mass spectrometry is used to determine concentrations of over 35 species along the flame centerline. Computational results are examined throughout each flame, and validation of the model occurs through comparison with centerline measurements. Very good agreement is observed for temperature, major species, and several minor species. As the level of additive is increased, temperatures, some major species (CO{sub 2}, C{sub 2}H{sub 2}), flame lengths, and residence times are essentially unchanged. However, peak centerline concentrations of benzene (C{sub 6}H{sub 6}) increase, and this increase is largest when dimethyl ether is the additive. Computational and experimental results support the hypothesis that the dominant pathway to C{sub 6}H{sub 6} formation begins with the oxygenates decomposing into methyl radical (CH{sub 3}), which combines with C2 species to form propargyl (C{sub 3}H{sub 3}), which reacts with itself to form C{sub 6}H{sub 6}. (author)

  10. A simple technique to reduce evaporation of crystallization droplets by using plate lids with apertures for adding liquids

    SciTech Connect (OSTI)

    Zipper, Lauren E.; Aristide, Xavier; Bishop, Dylan P.; Joshi, Ishita; Kharzeev, Julia; Patel, Krishna B.; Santiago, Brianna M.; Joshi, Karan; Dorsinvil, Kahille; Sweet, Robert M.; Soares, Alexei S.

    2014-11-28

    This article describes the use of evaporation control lids that are fitted to crystallization plates to improve the reproducibility of trials using as little as 5 nl. The plate lids contain apertures which are large enough for the transfer of protein containing droplets, but small enough to greatly reduce the rate of evaporation during the time needed to prepare the plate. A method is described for using plate lids to reduce evaporation in low-volume vapor-diffusion crystallization experiments. The plate lids contain apertures through which the protein and precipitants were added to different crystallization microplates (the reservoir was filled before fitting the lids). Plate lids were designed for each of these commonly used crystallization microplates. This system minimizes the dehydration of crystallization droplets containing just a few nanolitres of protein and precipitant, and results in more reproducible diffraction from the crystals. For each lid design, changes in the weight of the plates were used to deduce the rate of evaporation under different conditions of temperature, air movement, droplet size and precipitant. For comparison, the state of dehydration was also visually assessed throughout the experiment. Finally, X-ray diffraction methods were used to compare the diffraction of protein crystals that were conventionally prepared against those that were prepared on plates with plate lids. The measurements revealed that the plate lids reduced the rate of evaporation by 63‚Äď82%. Crystals grown in 5 nl drops that were set up with plate lids diffracted to higher resolution than similar crystals from drops that were set up without plate lids. The results demonstrate that plate lids can be instrumental for improving few-nanolitre crystallizations.

  11. Iron and aluminum interaction with amyloid-beta peptides associated with Alzheimer’s disease

    SciTech Connect (OSTI)

    Drochioiu, Gabi; Ion, Laura; Murariu, Manuela; Habasescu, Laura

    2014-10-06

    An elevation in the concentration of heavy metal ions in Alzheimer‚Äôs disease (AD) brain has been demonstrated in many studies. Aő≤ precipitation and toxicity in AD brains seem to be caused by abnormal interactions with neocortical metal ions, especially iron, copper, zinc, and aluminum [1‚Äď3]. There is increasing evidence that iron and aluminum ions are involved in the mechanisms that underlie the neurodegenerative diseases [4,5]. However, evidence was brought to demonstrate that some Aő≤ fragments, at physiological pH, are not able to form binary complexes with Fe(III) ions of sufficient stability to compete with metal hydroxide precipitation [6]. On the contrary, multiple metal ions are known to interact with Aő≤ peptides [7]. Consequently, we investigated here the interaction of Fe(II/III) and Al(III) ions with some amyloid-ő≤ peptides and fragments that results in peptide aggregation and fibrillation [8,9]. Infrared spectroscopy, atomic force microscopy, scanning electron microscopy, electrophoresis and mass spectrometry demonstrated conformational changes of peptides in the presence of such metals.

  12. Draft Genome Sequences for Clostridium thermocellum Wild-Type Strain YS and Derived Cellulose Adhesion-Defective Mutant Strain AD2

    SciTech Connect (OSTI)

    Brown, Steven D; Lamed, Raphael; Morag, Ely; Borovok, Ilya; Shoham, Yuval; Klingeman, Dawn Marie; Johnson, Courtney M; Yang, Zamin; Land, Miriam L; Utturkar, Sagar M; Keller, Martin; Bayer, Edward A

    2012-01-01

    Clostridium thermocellum wild-type strain YS is an anaerobic, thermophilic, cellulolytic bacterium capable of directly converting cellulosic substrates into ethanol. Strain YS and a derived cellulose adhesion-defective mutant strain AD2 played pivotal roles in describing the original cellulosome concept. We present their draft genome sequences.

  13. Therapeutic target for protozoal diseases

    DOE Patents [OSTI]

    Rathore, Dharmendar; Jani, Dewal; Nagarkatti, Rana

    2008-10-21

    A novel Fasciclin Related Adhesive Protein (FRAP) from Plasmodium and related parasites is provided as a target for therapeutic intervention in diseases caused by the parasites. FRAP has been shown to play a critical role in adhesion to, or invasion into, host cells by the parasite. Furthermore, FRAP catalyzes the neutralization of heme by the parasite, by promoting its polymerization into hemozoin. This invention provides methods and compositions for therapies based on the administration of protein, DNA or cell-based vaccines and/or antibodies based on FRAP, or antigenic epitopes of FRAP, either alone or in combination with other parasite antigens. Methods for the development of compounds that inhibit the catalytic activity of FRAP, and diagnostic and laboratory methods utilizing FRAP are also provided.

  14. Tracking Living Cells as They Differentiate in Real Time

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    these projects will target Alzheimer's disease, macular degeneration of the retina in diabetes, and mitochondrial diseases in children. In addition, specific processes like protein...

  15. Tracking Living Cells as They Differentiate in Real Time

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Alzheimer's disease, macular degeneration of the retina in diabetes, and mitochondrial diseases in children. In addition, specific processes like protein glycation can also be...

  16. Protein Instability and Lou Gehrig's Disease

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protein Instability and Lou Gehrig's Disease Print A new study links protein instability with the progression of a lethal degenerative disease: amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. Using several biophysical techniques as well as small-angle x-ray scattering (SAXS) at the Advanced Light Source, researchers focused on the effects of mutations to a gene coding for a protein called superoxide dismutase (SOD). The study provides evidence that those proteins linked

  17. Protein Instability and Lou Gehrig's Disease

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protein Instability and Lou Gehrig's Disease Print A new study links protein instability with the progression of a lethal degenerative disease: amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. Using several biophysical techniques as well as small-angle x-ray scattering (SAXS) at the Advanced Light Source, researchers focused on the effects of mutations to a gene coding for a protein called superoxide dismutase (SOD). The study provides evidence that those proteins linked

  18. Protein Instability and Lou Gehrig's Disease

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protein Instability and Lou Gehrig's Disease Print A new study links protein instability with the progression of a lethal degenerative disease: amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. Using several biophysical techniques as well as small-angle x-ray scattering (SAXS) at the Advanced Light Source, researchers focused on the effects of mutations to a gene coding for a protein called superoxide dismutase (SOD). The study provides evidence that those proteins linked

  19. Protein Instability and Lou Gehrig's Disease

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protein Instability and Lou Gehrig's Disease Print A new study links protein instability with the progression of a lethal degenerative disease: amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. Using several biophysical techniques as well as small-angle x-ray scattering (SAXS) at the Advanced Light Source, researchers focused on the effects of mutations to a gene coding for a protein called superoxide dismutase (SOD). The study provides evidence that those proteins linked

  20. Imaging of occupational and environmental lung diseases

    SciTech Connect (OSTI)

    Akira, M.

    2008-03-15

    The chest radiograph is the basic tool for identifying occupational and environmental lung diseases; however, its sensitivity and specificity for the diagnosis of occupational and environmental lung diseases are low. High-resolution CT is the optimal method of recognizing parenchymal abnormalities in occupational and environmental disease. With the exception of pleural plaques, the CT findings of occupational and environmental lung diseases are nonspecific. Therefore, correlation of imaging features with history of exposure, other clinical features, and sometimes pathology is needed for the diagnosis of pneumoconiosis.

  1. Protein Instability and Lou Gehrig's Disease

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    called superoxide dismutase (SOD). The study provides evidence that those proteins linked to more severe forms of the disease are less stable structurally and more prone to...

  2. OSTIblog Articles in the ADNI Topic | OSTI, US Dept of Energy Office of

    Office of Scientific and Technical Information (OSTI)

    Scientific and Technical Information ADNI Topic Sharing Data Leads to Progress by Nena Moss 19 Aug, 2010 in Personal Perspectives My mother died in March 2010 after a 15-year battle with Alzheimer's, so I pay particular attention to news about this dreadful disease. A recent New York Times article caught my eye: "Sharing of Data Leads to Progress on Alzheimer's." How did sharing data lead to progress on Alzheimer's? A collaborative effort, the Alzheimer's Disease Neuroimaging

  3. OSTIblog Articles in the biomarkers Topic | OSTI, US Dept of Energy Office

    Office of Scientific and Technical Information (OSTI)

    of Scientific and Technical Information biomarkers Topic Sharing Data Leads to Progress by Nena Moss 19 Aug, 2010 in Personal Perspectives My mother died in March 2010 after a 15-year battle with Alzheimer's, so I pay particular attention to news about this dreadful disease. A recent New York Times article caught my eye: "Sharing of Data Leads to Progress on Alzheimer's." How did sharing data lead to progress on Alzheimer's? A collaborative effort, the Alzheimer's Disease

  4. OSTIblog Articles in the corollary Topic | OSTI, US Dept of Energy Office

    Office of Scientific and Technical Information (OSTI)

    of Scientific and Technical Information corollary Topic Sharing Data Leads to Progress by Nena Moss 19 Aug, 2010 in Personal Perspectives My mother died in March 2010 after a 15-year battle with Alzheimer's, so I pay particular attention to news about this dreadful disease. A recent New York Times article caught my eye: "Sharing of Data Leads to Progress on Alzheimer's." How did sharing data lead to progress on Alzheimer's? A collaborative effort, the Alzheimer's Disease

  5. A Security Solution for IEEE 802.11's Ad-hoc Mode:Password-Authentication and Group Diffie-Hellman Key Exchange

    SciTech Connect (OSTI)

    Emmanuel, Bresson; Olivier, Chevassut; David, Pointcheval

    2005-10-01

    The IEEE 802 standards ease the deployment of networkinginfrastructures and enable employers to accesscorporate networks whiletraveling. These standards provide two modes of communication calledinfrastructure and ad-hoc modes. A security solution for the IEEE802.11's infrastructure mode took several years to reach maturity andfirmware are still been upgraded, yet a solution for the ad-hoc modeneeds to be specified. The present paper is a first attempt in thisdirection. It leverages the latest developments in the area ofpassword-based authentication and (group) Diffie-Hellman key exchange todevelop a provably-secure key-exchange protocol for IEEE 802.11's ad-hocmode. The protocol allows users to securely join and leave the wirelessgroup at time, accommodates either a single-shared password orpairwise-shared passwords among the group members, or at least with acentral server; achieves security against dictionary attacks in theideal-hash model (i.e. random-oracles). This is, to the best of ourknowledge, the first such protocol to appear in the cryptographicliterature.

  6. Disease Ontology 2015 update: An expanded and updated database of human diseases for linking biomedical knowledge through disease data

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Kibbe, Warren A.; Arze, Cesar; Felix, Victor; Mitraka, Elvira; Bolton, Evan; Fu, Gang; Mungall, Christopher J.; Binder, Janos X.; Malone, James; Vasant, Drashtti; et al

    2014-10-27

    The current version of the Human Disease Ontology (DO) (http://www.disease-ontology.org) database expands the utility of the ontology for the examination and comparison of genetic variation, phenotype, protein, drug and epitope data through the lens of human disease. DO is a biomedical resource of standardized common and rare disease concepts with stable identifiers organized by disease etiology. The content of DO has had 192 revisions since 2012, including the addition of 760 terms. Thirty-two percent of all terms now include definitions. DO has expanded the number and diversity of research communities and community members by 50+ during the past two years.more¬†¬Ľ These community members actively submit term requests, coordinate biomedical resource disease representation and provide expert curation guidance. Since the DO 2012 NAR paper, there have been hundreds of term requests and a steady increase in the number of DO listserv members, twitter followers and DO website usage. DO is moving to a multi-editor model utilizing Prot√©g√© to curate DO in web ontology language. In conclusion, this will enable closer collaboration with the Human Phenotype Ontology, EBI's Ontology Working Group, Mouse Genome Informatics and the Monarch Initiative among others, and enhance DO's current asserted view and multiple inferred views through reasoning.¬ę¬†less

  7. A Principal Component Analysis Noise Filter Value-Added Procedure to Remove Uncorrelated Noise from Atmospheric Emitted Radiance Interferometer (AERI) Observations

    SciTech Connect (OSTI)

    C. Lo D. D. Turner R. O. Knuteson

    2006-01-31

    This technical report provide a short description of the application of the principle component analysis techniques to remove uncorrelated random noise from ground-based high spectral resolution infrared radiance observations collected by the atmospheric emitted radiance interferometers (AERIs) deployed by the Atmospheric Radiation Measurement (ARM) Program. A general overview of the technique, the input, and output datastreams of the newly generated value-added product, and the data quality checks used are provided. A more complete discussion of the theory and results is given in Turner et al. (2006).

  8. Protein Instability and Lou Gehrig's Disease

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    1941 at the age of only 38. Recently, an award-winning movie about the famous physicist, Stephen Hawking, depicted the disease's devastating physical toll. ALS kills by destroying...

  9. Metabolomics reveals metabolic biomarkers of Crohn's disease

    SciTech Connect (OSTI)

    Jansson, J.K.; Willing, B.; Lucio, M.; Fekete, A.; Dicksved, J.; Halfvarson, J.; Tysk, C.; Schmitt-Kopplin, P.

    2009-06-01

    The causes and etiology of Crohn's disease (CD) are currently unknown although both host genetics and environmental factors play a role. Here we used non-targeted metabolic profiling to determine the contribution of metabolites produced by the gut microbiota towards disease status of the host. Ion Cyclotron Resonance Fourier Transform Mass Spectrometry (ICR-FT/MS) was used to discern the masses of thousands of metabolites in fecal samples collected from 17 identical twin pairs, including healthy individuals and those with CD. Pathways with differentiating metabolites included those involved in the metabolism and or synthesis of amino acids, fatty acids, bile acids and arachidonic acid. Several metabolites were positively or negatively correlated to the disease phenotype and to specific microbes previously characterized in the same samples. Our data reveal novel differentiating metabolites for CD that may provide diagnostic biomarkers and/or monitoring tools as well as insight into potential targets for disease therapy and prevention.

  10. Zika Virus Disease and Prevention Presentation

    Broader source: Energy.gov [DOE]

    A ‚ÄúZika Virus Disease and Prevention‚ÄĚ presentation was made by Bonnie S. Richter, MPH, PhD, at the May 19 Office of Environment, Health, Safety and Security (EHSS) All Hands Meeting.