Sample records for activities in cluding

  1. Child neurology: Autism as a model: Considerations for advanced training in behavioral child neurology

    E-Print Network [OSTI]

    Jeste, SS; Friedman, SL; Urion, DK

    2009-01-01T23:59:59.000Z

    through outpatient clinics and didactics, there is no formalneuropsychological assessments. Didactics would in- clude

  2. 2. Cantino EC (1966) In: The Fungi, Vol 2 (Ainsworth, GS and Sussman AS, eds),

    E-Print Network [OSTI]

    Boyer, Edmond

    1966-01-01T23:59:59.000Z

    hydrogenosomes are probably derived from mitochondria. This data in- cludes primary sequences of hydrogeno- somal

  3. Fast 3D Brain Segmentation Using Dual-Front Active Contours with Optional User-Interaction

    E-Print Network [OSTI]

    Cohen, Laurent

    Fast 3D Brain Segmentation Using Dual-Front Active Contours with Optional User-Interaction Hua Li1 attributes of 3D brain segmentation algorithms in- clude robustness, accuracy, computational efficiency result. We propose a novel 3D brain cortex segmentation procedure utilizing dual- front active contours

  4. WASTE DISPOSAL IN GRANITE: PRELIMINARY RESULTS FROM STRIPA, SWEDEN

    E-Print Network [OSTI]

    Cook, N.G.W.

    2010-01-01T23:59:59.000Z

    of intact specimens cf granite are of the order of onemost hard rock, in­ cluding granite. Is Interrupted by setsthe pro­ perties of the granite as measured in laboratory

  5. Federal Activities in the Bioeconomy

    Broader source: Energy.gov [DOE]

    Plenary V: Federal Activities in the Bioeconomy Federal Activities in the Bioeconomy Zia Haq, Senior Analyst, Technology Manager, Bioenergy Technologies Office, U.S. Department of Energy

  6. In Search of Big Instructions Arrvindh Shriraman, Sandhya Dwarkadas, and Michael L. Scott

    E-Print Network [OSTI]

    Scott, Michael L.

    and energy efficiency. Examples in- clude vector and matrix operations, and common mathematical functions of instructions in the ISA. Our premise is that future ISAs need to return to the traditional CISC philoso- phy

  7. Science Activities in Biomass

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiationImplementingnpitcheResearch BriefsTenney, Office of ScienceActivities in Biomass

  8. 388 Federal Funds--Continued ENVIRONMENTAL AND OTHER DEFENSE ACTIVITIES--Continued

    E-Print Network [OSTI]

    will be responsible for the management and implemen- tation of the Department's National Spent Fuel Program, which final dis- position of all Departmental spent nuclear fuel. In addition, the program will be responsible for management of the For- eign Research Reactor Spent Fuel Acceptance Program, in- cluding the planning

  9. Active OB stars: structure, evolution, mass loss and critical limits Proceedings IAU Symposium No. 272, 2011

    E-Print Network [OSTI]

    post main sequence in- cluding the gamma-ray bursts. Finally, the different new results and remaining fields, stars: oscillations (including pulsations), binaries: general, surveys, gamma rays: bursts 1 pulsations, the rotational velocity, and the binarity (including the X-rays binaries) on the Be phenomenon

  10. Lab active in support of science activities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh SchoolIn12electron 9 5 - -/e),,s -Lab Subcontractoractive in support

  11. International Collaboration Activities in Different Geologic...

    Energy Savers [EERE]

    065InternationalCollabActivities2014 More Documents & Publications Status of UFD Campaign International Activities in Disposal Research Natural System Evaluation and Tool...

  12. Nuclear Activity in Nearby Galaxies

    E-Print Network [OSTI]

    Thaisa Storchi-Bergmann

    1999-03-03T23:59:59.000Z

    I discuss some recent observational results in the research of nearby active galactic nuclei (AGN). These results cover three main topics: (i) evidences for the current paradigm for AGN's, which include a nuclear supermassive blackhole (SMBH) fed via an accretion disk; (ii) evidence that this paradigm may also apply to LINER's, the lowest luminous AGN's and to normal galaxies; (iii) evidences of how the fueling of the SMBH occurs and its relation to recent and intermediate age (10^6 to 10^8 yrs old) episodes of star formation.

  13. Comparison of the percent recoveries of activated charcoal and Spherocarb after storage utilizing thermal desorption

    E-Print Network [OSTI]

    Stidham, Paul Emery

    1980-01-01T23:59:59.000Z

    between the two adsorbents. The parameters of storage in- cluded various durations of time, temperatures, and concentrations. Rather than the present conventional solvent desorption methods, thermal desorption was used in the analysis of samples... Duncan's Multiple Range Test For Variable Percent. 32 6 Mean Percent Recoveries For The Interaction Between Type Of Adsorbent And Storage Time . 7 Mean Percent Recoveries For The Interaction Between Sample Concentration And Storage Time. 39 40 8...

  14. Active materials in photonic crystals

    E-Print Network [OSTI]

    Bermel, Peter (Peter A.)

    2007-01-01T23:59:59.000Z

    I analyze new phenomena arising from embedding active materials inside of photonic crystal structures. These structures strongly modify the photonic local density of states (LDOS), leading to quantitative and qualitative ...

  15. Digital Watermark Detection in Visual Multimedia Content

    E-Print Network [OSTI]

    Uhl, Andreas

    Digital Watermark Detection in Visual Multimedia Content Peter Meerwald Cumulative thesis (online or video. Watermark detection is an integral component of a watermarking system. This cumulative thesis. The computational effort for blind, spread-spectrum watermark detection is analyzed in- cluding the determination

  16. Measuring Similarity in Large-scale Folksonomies Giovanni Quattrone1

    E-Print Network [OSTI]

    Ferrara, Emilio

    Measuring Similarity in Large-scale Folksonomies Giovanni Quattrone1 , Emilio Ferrara2 , Pasquale by power law distributions of tags, over which commonly used similarity metrics, in- cluding the Jaccard to capture similarity in large-scale folksonomies, that is based on a mutual reinforcement principle: that is

  17. USING RANDOM MATRIX THEORY TO DETERMINE THE NUMBER OF ENDMEMBERS IN A HYPERSPECTRAL IMAGE

    E-Print Network [OSTI]

    Damelin, Steven

    chemical unmixing [1], extracting speech signals in a noisy band [2], unmixing minerals [3] and unmixing en of spectral endmembers in a hyper- spectral image is an important step in the spectral unmixing process of endmembers in an image is im- portant for the processing of many different types of data, in- cluding

  18. Deciphering Solar Magnetic Activity: On Grand Minima in Solar Activity

    E-Print Network [OSTI]

    McIntosh, Scott W

    2015-01-01T23:59:59.000Z

    The Sun provides the energy necessary to sustain our existence. While the Sun provides for us, it is also capable of taking away. The weather and climatic scales of solar evolution and the Sun-Earth connection are not well understood. There has been tremendous progress in the century since the discovery of solar magnetism - magnetism that ultimately drives the electromagnetic, particulate and eruptive forcing of our planetary system. There is contemporary evidence of a decrease in solar magnetism, perhaps even indicators of a significant downward trend, over recent decades. Are we entering a minimum in solar activity that is deeper and longer than a typical solar minimum, a "grand minimum"? How could we tell if we are? What is a grand minimum and how does the Sun recover? These are very pertinent questions for modern civilization. In this paper we present a hypothetical demonstration of entry and exit from grand minimum conditions based on a recent analysis of solar features over the past 20 years and their p...

  19. INTRODUCTION In both the military and commercial sectors,

    E-Print Network [OSTI]

    Virginia, University of

    vehicles (UAVs), unmanned air combat vehicles, unmanned underwater vehicles, and a plethora of ground and develop- ment in the field of unmanned vehicles, which in- clude remotely piloted vehicles, unmanned air of the expected future use of clusters of unmanned vehicles that can both re- spond to human commands as well

  20. Short Communication Epidemiology of Staphylococcus aureus in Pigs

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    -Valentine leukocidin (PVL), present in 43 (58.9%) isolates overall, in- cluding all major CCs and the MRSA ST5-SCCmec of methicillin-resistant Staphy- lococcus aureus (MRSA) strains has become a serious challenge for human infection control and antibiotic therapy. Livestock-associated MRSA strains (LA-MRSA) have recently emerged

  1. INVEST IN YOUR BONES Daily Activities

    E-Print Network [OSTI]

    INVEST IN YOUR BONES Daily Activities Leaflet 3 Another osteoporosis prevention step to decrease lifestyle. Let's see how you can do that. If you have osteoporosis, follow carefully the activity program. Remember the following about osteoporosis: is largely preventable and treatable is a serious

  2. Mobile Robotics Activities in DOE Laboratories

    SciTech Connect (OSTI)

    Ron Lujan; Jerry Harbour; John T. Feddema; Sharon Bailey; Jacob Barhen; David Reister

    2005-03-01T23:59:59.000Z

    This paper will briefly outline major activities in Department of Energy (DOE) Laboratories focused on mobile platforms, both Unmanned Ground Vehicles (UGV’s) as well as Unmanned Air Vehicles (UAV’s). The activities will be discussed in the context of the science and technology construct used by the DOE Technology Roadmap for Robotics and Intelligent Machines (RIM)1 published in 1998; namely, Perception, Reasoning, Action, and Integration. The activities to be discussed span from research and development to deployment in field operations. The activities support customers in other agencies. The discussion of "perception" will include hyperspectral sensors, complex patterns discrimination, multisensor fusion and advances in LADAR technologies, including real-world perception. "Reasoning" activities to be covered include cooperative controls, distributed systems, ad-hoc networks, platform-centric intelligence, and adaptable communications. The paper will discuss "action" activities such as advanced mobility and various air and ground platforms. In the RIM construct, "integration" includes the Human-Machine Integration. Accordingly the paper will discuss adjustable autonomy and the collaboration of operator(s) with distributed UGV’s and UAV’s. Integration also refers to the applications of these technologies into systems to perform operations such as perimeter surveillance, large-area monitoring and reconnaissance. Unique facilities and test beds for advanced mobile systems will be described. Given that this paper is an overview, rather than delve into specific detail in these activities, other more exhaustive references and sources will be cited extensively.

  3. Energetics of active fluctuations in living cells

    E-Print Network [OSTI]

    Étienne Fodor; Kiyoshi Kanazawa; Hisao Hayakawa; Paolo Visco; Frédéric van Wijland

    2014-06-06T23:59:59.000Z

    The nonequilibrium activity taking place in a living cell can be monitored with a tracer embedded in the medium. While microrheology experiments based on optical manipulation of such probes have become increasingly standard, we put forward a number of experiments with alternative protocols that, we claim, will provide new insight into the energetics of active fluctuations. These are based on either performing thermodynamic--like cycles in control-parameter space, or on determining response to external perturbations of the confining trap beyond simple translation. We illustrate our proposals on an active itinerant Brownian oscillator modeling the dynamics of a probe embedded in a living medium.

  4. Broad-Scale Analysis Contradicts the Theory That Generation Time Affects Molecular Evolutionary Rates in Plants

    E-Print Network [OSTI]

    Johnston, Mark

    Abstract. Several studies of plant taxa have con- cluded that generation time, including annual/ perennial in animals, there is little theoretical basis for why generation-time effects would exist in plants. Furthermore, previous reports fail to establish the generality of a generation-time effect in plants be- cause

  5. Rhythm Reproduction in Kindergarten, Reading Performance at Second Grade, and Developmental Dyslexia Theories

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Dyslexia Theories Georges Dellatolasa,b,*, Laurence Watierb, Marie-The´re`se Le Normanda, Todd Lubarta to read. In 1951, Stambak provided preliminary evi- dence that children with dyslexia performed less well-related theories of developmental dyslexia. It is con- cluded that simple rhythm reproduction tasks in kindergarten

  6. Distributed Intelligence: Overview of the Field and its Application in Multi-Robot Systems

    E-Print Network [OSTI]

    Parker, Lynne E.

    or system, in- cluding agents, humans, robots, smart sensors, and so forth. In these systems, different carrier flight deck, who are segmented into the catapult crew, the landing signal officers, ordnance- men, sensors, computer systems, and even people and animals (such as search and rescue dogs) that can work

  7. Characteristic temperature in magnetically doped amorphous semiconductors E. Helgren, J. J. Cherry, L. Zeng, and F. Hellman

    E-Print Network [OSTI]

    Hellman, Frances

    such as Gd into amorphous Si produces dramatic effects in electrical transport below a characteristic causes dra- matic effects in the magnetic and transport properties, in- cluding enormous negative glass freezing temperature, Tf. However T* represents a funda- mentally different magnetic thermal

  8. Interactive Activation in Perception and Cognition 1 Interactive Activation and Mutual Constraint Satisfaction

    E-Print Network [OSTI]

    McClelland, James L. "Jay"

    Interactive Activation in Perception and Cognition 1 Interactive Activation and Mutual Constraint on Rumelhart's arguments, we present the Interactive Activation hypothesis ­ the idea that the mechanism used in perception and comprehension to achieve these feats exploits an interactive activation process implemented

  9. IMPROVEMENTS IN MODELLING DISSOLVED OXYGEN IN ACTIVATED SLUDGE SYSTEMS

    E-Print Network [OSTI]

    Wells, Scott A.

    1 IMPROVEMENTS IN MODELLING DISSOLVED OXYGEN IN ACTIVATED SLUDGE SYSTEMS Jacek Makinia*, Scott A in a full-scale activated sludge reactor. The Activated Sludge Model No. 1 was used to describe for dissolved oxygen. KEYWORDS Activated sludge; dispersion; dissolved oxygen dynamics; mass transfer

  10. Localization in active incommensurate arrays

    E-Print Network [OSTI]

    T. V. Laptyeva; S. V. Denisov; G. V. Osipov; M. V. Ivanchenko

    2014-12-01T23:59:59.000Z

    In a dissipationless linear lattice, spatial disorder or incommensurate modulation induce localization of the lattice eigenstates and block spreading of wave packets. Additionally, incommensurate arrays allow for the metal-insulator transition at a finite modulation amplitude already in one dimension. The addition of nonlinearity to the lattice Hamiltonian causes interaction between the eigenstates, which results in a slow packet spreading. We go beyond the dissipationless limit and consider nonlinear quasi-periodic arrays that are subjected to the dissipative losses and energy pumping. We find that there is a finite excitation of oscillations threshold in both metallic and insulating regimes. Moreover, excitation in the metallic and weakly insulating regime displays features of the second order phase transition to global oscillations, in contrast to disordered arrays. The Anderson attractor regime is recovered only in the limit of strong localization. The identified transition, and the further onset of chaos and synchronization can be potentially realized with polariton condensates lattices and cavity-QED arrays.

  11. Japan’s Defense White Paper as a Tool for Promoting Defense Transparency

    E-Print Network [OSTI]

    SUKEGAWA, Yasushi

    2012-01-01T23:59:59.000Z

    and activities of the MOD/SDF (Part III). It is one of theof the Self-Defense Forces (SDF) came to be in- cluded inits coverage to include the SDF’s disaster respons- es and

  12. Mon. Not. R. Astron. Soc. 000, 000--000 (1994) The detection of hot ethanol in G34.3+0.15

    E-Print Network [OSTI]

    Millar, Tom

    Mon. Not. R. Astron. Soc. 000, 000--000 (1994) The detection of hot ethanol in G34.3+0.15 T. J rotational transitions of ethanol in the submillimetre spectrum of the molecular cloud associated, cannot be made by purely gas­phase processes, and we con­ clude that the ethanol must be formed

  13. An analysis of levels of living of Spanish-American rural and urban families in two South Texas counties

    E-Print Network [OSTI]

    Clements, Harold McCutcheon

    1963-01-01T23:59:59.000Z

    of tlousing, medical Servicesg educational *' cgzities, local gcveznment exz andi tures and communitJ services in tnres major rag~Gus oz the Jnited States l the gorth, South and Meet. They COnCluded titus &ZJZaz PeOPle . -lore diaadV=ntt gedg Ccm...

  14. Phase separation and coarsening in active matter

    E-Print Network [OSTI]

    Giuseppe Gonnella; Davide Marenduzzo; Antonio Suma; Adriano Tiribocchi

    2015-02-08T23:59:59.000Z

    Active systems, or active matter, are self-driven systems which live, or function, far from equilibrium - a paradigmatic example which we focus on here is provided by a suspension of self-motile particles. Active systems are far from equilibrium because their microscopic constituents constantly consume energy from the environment in order to do work, for instance to propel themselves. The nonequilibrium nature of active matter leads to a variety of non-trivial intriguing phenomena. An important one which has recently been the subject of intense interest among biological and soft matter physicists is that of the so-called "motility-induced phase separation", whereby self-propelled particles accumulate into clusters in the absence of any explicit attractive interactions between them. Here we review the physics of motility-induced phase separation, and discuss this phenomenon within the framework of the classic physics of phase separation and coarsening. We also discuss cases where the coarsening may be arrested, either in theories for bacterial colonies or in experiments. Most of this work will focus on the case of run-and-tumble and active Brownian particles in the absence of solvent-mediated hydrodynamic interactions - we will briefly discuss at the end their role, which is not currently fully understood in this context.

  15. urricane activity in the Atlantic basin increased

    E-Print Network [OSTI]

    with levels in the 1970s and 1980s. For example, the accumulated cyclone energy (ACE) index in the Atlantic of disturbances. Bottom: annual number (Aug­Oct) of North Atlantic basin hurricanes (1980­2005). See figures 2, is a crucial question for the future outlook of hurricane activity in the basin. It is difficult to distinguish

  16. Activity-induced phase separation and self-assembly in mixtures of active and passive particles

    E-Print Network [OSTI]

    Joakim Stenhammar; Raphael Wittkowski; Davide Marenduzzo; Michael E. Cates

    2015-01-07T23:59:59.000Z

    We investigate the phase behavior and kinetics of a monodisperse mixture of active (\\textit{i.e.}, self-propelled) and passive isometric Brownian particles through Brownian dynamics simulations and theory. As in a purely active system, motility of the active component triggers phase separation into a dense and a dilute phase; in the dense phase we further find active-passive segregation, with "rafts" of passive particles in a "sea" of active particles. We find that phase separation from an initially disordered mixture can occur with as little as 15 percent of the particles being active. Finally, we show that a system prepared in a suitable fully segregated initial state reproducibly self-assembles an active "corona" which triggers crystallization of the passive core by initiating a compression wave. Our findings are relevant to the experimental pursuit of directed self-assembly using active particles.

  17. A Summary of Control System Security Standards Activities in...

    Energy Savers [EERE]

    A Summary of Control System Security Standards Activities in the Energy Sector (October 2005) A Summary of Control System Security Standards Activities in the Energy Sector...

  18. Activities to Secure Control Systems in the Energy Sector | Department...

    Office of Environmental Management (EM)

    Activities to Secure Control Systems in the Energy Sector Activities to Secure Control Systems in the Energy Sector Presentation-given at the Federal Utility Partnership Working...

  19. Spontaneous motion in hierarchically assembled active matter

    E-Print Network [OSTI]

    Tim Sanchez; Daniel T. N. Chen; Stephen J. DeCamp; Michael Heymann; Zvonimir Dogic

    2013-01-07T23:59:59.000Z

    With exquisite precision and reproducibility, cells orchestrate the cooperative action of thousands of nanometer-sized molecular motors to carry out mechanical tasks at much larger length scales, such as cell motility, division and replication. Besides their biological importance, such inherently non-equilibrium processes are an inspiration for developing biomimetic active materials from microscopic components that consume energy to generate continuous motion. Being actively driven, these materials are not constrained by the laws of equilibrium statistical mechanics and can thus exhibit highly sought-after properties such as autonomous motility, internally generated flows and self-organized beating. Starting from extensile microtubule bundles, we hierarchically assemble active analogs of conventional polymer gels, liquid crystals and emulsions. At high enough concentration, microtubules form a percolating active network characterized by internally driven chaotic flows, hydrodynamic instabilities, enhanced transport and fluid mixing. When confined to emulsion droplets, 3D networks spontaneously adsorb onto the droplet surfaces to produce highly active 2D nematic liquid crystals whose streaming flows are controlled by internally generated fractures and self-healing, as well as unbinding and annihilation of oppositely charged disclination defects. The resulting active emulsions exhibit unexpected properties, such as autonomous motility, which are not observed in their passive analogues. Taken together, these observations exemplify how assemblages of animate microscopic objects exhibit collective biomimetic properties that are starkly different from those found in materials assembled from inanimate building blocks, challenging us to develop a theoretical framework that would allow for a systematic engineering of their far-from-equilibrium material properties.

  20. Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells

    E-Print Network [OSTI]

    Das, Jayajit

    Activation of Ras proteins underlies functional decisions in diverse cell types. Two molecules, RasGRP and SOS, catalyze Ras activation in lymphocytes. Binding of active Ras to SOS' allosteric pocket markedly increases ...

  1. The Sun in Time: Activity and Environment

    E-Print Network [OSTI]

    M. Guedel

    2007-12-11T23:59:59.000Z

    (abridged) The Sun's magnetic activity has steadily declined during its main-sequence life. While the solar photospheric luminosity was about 30% lower 4.6 Gyr ago when the Sun arrived on the main sequence compared to present-day levels, its faster rotation generated enhanced magnetic activity; magnetic heating processes in the chromosphere, the transition region, and the corona induced ultraviolet, extreme-ultraviolet, and X-ray emission about 10, 100, and 1000 times, respectively, the present-day levels, as inferred from young solar-analog stars. Also, the production rate of accelerated, high-energy particles was orders of magnitude higher than in present-day solar flares, and a much stronger wind escaped from the Sun, permeating the entire solar system. The consequences of the enhanced radiation and particle fluxes from the young Sun were potentially severe for the evolution of solar-system planets and moons. Interactions of high-energy radiation and the solar wind with upper planetary atmospheres may have led to the escape of important amounts of atmospheric constituents. The present dry atmosphere of Venus and the thin atmosphere of Mars may be a product of early irradiation and heating by solar high-energy radiation. High levels of magnetic activity are also inferred for the pre-main sequence Sun. At those stages, interactions of high-energy radiation and particles with the circumsolar disk in which planets eventually formed were important. Traces left in meteorites by energetic particles and anomalous isotopic abundance ratios in meteoritic inclusions may provide evidence for a highly active pre-main sequence Sun. The present article reviews these various issues related to the magnetic activity of the young Sun and the consequent interactions with its environment.

  2. Activities and Accomplishments in Model Year 2007

    SciTech Connect (OSTI)

    Not Available

    2008-09-01T23:59:59.000Z

    Document summarizes the compliance activity of EPAct-covered state and alternative fuel provider fleets.

  3. Are Increases in Thunderstorm Activity in Southeast China Related...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Increases in Thunderstorm Activity in Southeast China Related to Air Pollution? For original submission and image(s), see ARM Research Highlights http:www.arm.govscience...

  4. AN ANNOTATED BIBLIOGRAPHY OF GRASP PART I: ALGORITHMS

    E-Print Network [OSTI]

    Resende, Mauricio G. C.

    of such techniques in- clude simulated annealing (Kirkpatrick, 1984), tabu search (Glover, 1989, 1990; Glover

  5. AGN Activity in Giant LSB Galaxies

    E-Print Network [OSTI]

    James Schombert

    1998-06-30T23:59:59.000Z

    A search of large, HI-rich disk galaxies finds a significantly higher fraction of low luminosity AGN signatures compared to other late-type galaxies. Approximately half of the galaxies selected in this sample have AGN-like behavior in their cores, the rest have HII nuclei resulting from simple star formation. Since AGN behavior is not evident in all the sample galaxies, which where selected by high gas mass, we speculate that it is the fuel flow rate that is the common feature between late-type LSB disks and other active nuclear galaxies.

  6. Activin inhibits telomerase activity in cancer

    SciTech Connect (OSTI)

    Katik, Indzi; Mackenzie-Kludas, Charley; Nicholls, Craig [Department of Immunology, Monash University, Melbourne (Australia)] [Department of Immunology, Monash University, Melbourne (Australia); Jiang, Fang-Xu [Centre for Diabetes Research, Western Australian Institute for Medical Research and The University of Western Australia, Perth (Australia)] [Centre for Diabetes Research, Western Australian Institute for Medical Research and The University of Western Australia, Perth (Australia); Zhou, Shufeng [School of Health Sciences, RMIT University, Melbourne (Australia)] [School of Health Sciences, RMIT University, Melbourne (Australia); Li, He [Department of Immunology, Monash University, Melbourne (Australia)] [Department of Immunology, Monash University, Melbourne (Australia); Liu, Jun-Ping, E-mail: jun-ping.liu@med.monash.edu.au [Department of Immunology, Monash University, Melbourne (Australia)] [Department of Immunology, Monash University, Melbourne (Australia)

    2009-11-27T23:59:59.000Z

    Activin is a pleiotropic cytokine with broad tissue distributions. Recent studies demonstrate that activin-A inhibits cancer cell proliferation with unknown mechanisms. In this report, we demonstrate that recombinant activin-A induces telomerase inhibition in cancer cells. In breast and cervical cancer cells, activin-A resulted in telomerase activity in a concentration-dependent manner. Significant inhibition was observed at 10 ng/ml of activin-A, with a near complete inhibition at 80 ng/ml. Consistently, activin-A induced repression of the telomerase reverse transcriptase (hTERT) gene, with the hTERT gene to be suppressed by 60-80% within 24 h. In addition, activin-A induced a concomitant increase in Smad3 signaling and decrease of the hTERT gene promoter activity in a concentration-dependent fashion. These data suggest that activin-A triggered telomerase inhibition by down-regulating hTERT gene expression is involved in activin-A-induced inhibition of cancer cell proliferation.

  7. Business Activities in an Industrial Context Boris Gruschko1

    E-Print Network [OSTI]

    Turau, Volker

    Business Activities in an Industrial Context Boris Gruschko1 , Friedrich H. Vogt1 , Simon for an encapsulated business activity, hidden behind a well-defined interface. This abstraction fosters the view of complex business activities, as interactions between Services, allowing for an agile business activity

  8. Curvature Induced Activation of a Passive Tracer in an Active Bath

    E-Print Network [OSTI]

    S. A. Mallory; C. Valeriani; A. Cacciuto

    2014-09-25T23:59:59.000Z

    We use numerical simulations to study the motion of a large asymmetric tracer immersed in a low density suspension of self-propelled nanoparticles in two dimensions. Specifically, we analyze how the curvature of the tracer affects its translational and rotational motion in an active environment. We find that even very small amounts of curvature are sufficient for the active bath to impart directed motion to the tracer which results in its effective activation. We propose simple scaling arguments to characterize this induced activity in terms of the curvature of the tracer and the strength of the self-propelling force. Our results suggest new ways of controlling the transport properties of passive tracers in an active medium by carefully tailoring their geometry.

  9. Noiseless nonreciprocity in a parametric active device

    E-Print Network [OSTI]

    Archana Kamal; John Clarke; Michel Devoret

    2010-10-08T23:59:59.000Z

    Nonreciprocal devices such as circulators and isolators belong to an important class of microwave components employed in applications like the measurement of mesoscopic circuits at cryogenic temperatures. The measurement protocols usually involve an amplification chain which relies on circulators to separate input and output channels and to suppress backaction from different stages on the sample under test. In these devices the usual reciprocal symmetry of circuits is broken by the phenomenon of Faraday rotation based on magnetic materials and fields. However, magnets are averse to on-chip integration, and magnetic fields are deleterious to delicate superconducting devices. Here we present a new proposal combining two stages of parametric modulation emulating the action of a circulator. It is devoid of magnetic components and suitable for on-chip integration. As the design is free of any dissipative elements and based on reversible operation, the device operates noiselessly, giving it an important advantage over other nonreciprocal active devices for quantum information processing applications.

  10. Stress reorganisation and response in active solids

    E-Print Network [OSTI]

    Rhoda J. Hawkins; Tanniemola B. Liverpool

    2014-07-14T23:59:59.000Z

    We present a microscopic model of a disordered viscoelastic active solid, i.e. an active material whose long time behaviour is elastic as opposed to viscous. It is composed of filaments, passive crosslinks and molecular motors powered by stored chemical energy, e.g. actomyosin powered by ATP. Our model allows us to study the collective behaviour of contractile active elements and how their interaction with each other and the passive elastic elements determines the macroscopic mechanical properties of the active material. As a result of the (un)binding dynamics of the active elements, we find that this system provides a highly responsive material with a dynamic mechanical response strongly dependent on the amount of deformation.

  11. iCalm: Measuring electrodermal activity in almost any setting

    E-Print Network [OSTI]

    Hedman, Elliott Bruce

    The iCalm sensor is a wireless, wearable, washable wristband that can measure electrodermal activity and physical activity in almost any natural setting. This platform has many applications including health monitoring for ...

  12. Clinical Activity in the New Chart of Accounts

    E-Print Network [OSTI]

    Klein, Ophir

    Clinical Activity in the New Chart of Accounts Parnassus ­ HSW 302 November 15th, 2012 1-3pm #12;Agenda Clinical activities in the new COA Understand how to align reporting with new COA 2 #12;Objectives Purpose of new chart of accounts for clinical activities: Standardize the treatment of clinical

  13. Melanin as an active layer in biosensors

    SciTech Connect (OSTI)

    Piacenti da Silva, Marina, E-mail: marinaness@yahoo.com; Congiu, Mirko, E-mail: congiumat@gmail.com; Oliveira Graeff, Carlos Frederico de, E-mail: graeff@fc.unesp.br [Department of Physics, Faculty of Sciences - UNESP, Bauru, SP (Brazil); Fernandes, Jéssica Colnaghi, E-mail: jeziga-cf@yahoo.com.br; Biziak de Figueiredo, Natália, E-mail: natbiziak@yahoo.com.br; Mulato, Marcelo, E-mail: mmulato@ffclrp.usp.br [Department of Physics, Faculty of Philosophy, Science and Letters at Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP (Brazil)] [Department of Physics, Faculty of Philosophy, Science and Letters at Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP (Brazil)

    2014-03-15T23:59:59.000Z

    The development of pH sensors is of great interest due to its extensive application in several areas such as industrial processes, biochemistry and particularly medical diagnostics. In this study, the pH sensing properties of an extended gate field effect transistor (EGFET) based on melanin thin films as active layer are investigated and the physical mechanisms related to the device operation are discussed. Thin films were produced from different melanin precursors on indium tin oxide (ITO) and gold substrates and were investigated by Atomic Force Microscopy and Electrochemical Impedance Spectroscopy. Experiments were performed in the pH range from 2 to 12. EGFETs with melanin deposited on ITO and on gold substrates showed sensitivities ranging from 31.3 mV/pH to 48.9 mV/pH, depending on the melanin precursor and the substrate used. The pH detection is associated with specific binding sites in its structure, hydroxyl groups and quinone imine.

  14. Role of Money in Rural Family Living.

    E-Print Network [OSTI]

    Nelson, Bardin H.

    1961-01-01T23:59:59.000Z

    area of Texas to determine if family patterns concerning the use of money follow traditional values associated with subsistence farming or values associated with commercial farming. The six sample counties in- cluded in the study were Collin, Hunt... commercial farming culture. The acceptance rate of new values varies from one family to another. Cultural norms concerning right and wrong adjust- ments have been slow in developing. Until a more clearcut basis is developed to define social roles...

  15. Activity based interfaces in online social networks

    E-Print Network [OSTI]

    Laraqui, Jawad

    2007-01-01T23:59:59.000Z

    The goal of the project is to explore how activity-based interfaces can create more meaningful experiences for the users and builders of online social networking sites. Medina, a social-networking site based on the idea ...

  16. Growing Up in Scotland: Food and Activity - Summary Report 

    E-Print Network [OSTI]

    Government, Scottish

    2009-03-18T23:59:59.000Z

    This report uses data from the Growing Up in Scotland study to explore issues related to, food and activity in Scotland specifically in relation to young children....

  17. Activities of Building Commissioning in Japan

    E-Print Network [OSTI]

    Yanagihara, R.

    2006-01-01T23:59:59.000Z

    for Commissioning Guideline ?? BSCA Activity for Promotin g Commissionin g BSCA Activity for Promotin g Commissionin g BusinessBusiness ?? Actual ProjectActual Project ??Harumi Islands District Heating and CoolingHarumi Islands District Heating and Cooling... scale DHC(District Large scale DHC(District Heating and Cooling) Heating and Cooling) introduced introduced the heat pump and thermal the heat pump and thermal storage system with the aim of storage system with the aim of achieving minimum energy...

  18. Temperature Modeling in Activated Sludge Systems: A Case Study

    E-Print Network [OSTI]

    Wells, Scott A.

    Temperature Modeling in Activated Sludge Systems: A Case Study Jacek Makinia, Scott A. Wells, Piotr Zima ABSTRACT: A model of temperature dynamics was developed as part of a general model of activated-sludge biochemical-energy inputs and other activated-sludge, heat-balance terms. All the models were tested under

  19. IN VITRO MUTAGENIC AND DNA AND CHROMOSOMAL DAMAGE ACTIVITY BY...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    IN VITRO MUTAGENIC AND DNA AND CHROMOSOMAL DAMAGE ACTIVITY BY SURFACTANT DISPERSION OR SOLVENT EXTRACT OF A REFERENCE DIESEL EXHAUST PARTICULATE MATERIAL IN VITRO MUTAGENIC AND DNA...

  20. Participation of free radicals in the photodecomposition of active dyes

    SciTech Connect (OSTI)

    Anisimov, V.M.; Anisimova, O.M.; Dzhanashvilli, M.E.; Krichevskii, G.E.

    1985-06-10T23:59:59.000Z

    This paper investigates the effect of the free radicals in the medium on the photodecomposition of these active azo and anthraquinone dyes. The semilogarithmic anamorphoses of the kinetic curves showed that the rate of consumption of nitroxyl radical decreased in time in the presence of the dyes. The efficiency of the photodecomposition of the active dyes in an ETC film in the presence and absence of benzyl was studied to evaluate the role of free radicals in the photobleaching of the dies. The kinetic dependences obtained for active yellow 2KT are shown. The relative efficiency of the photoinitiation of free radicals by some active dyes was determined.

  1. Active Open Space (playing fields) in a

    E-Print Network [OSTI]

    environmental and social benefits, the unintended consequence of implementing Bush Forever, Water Sensitive of the fringe growth sub- regions of Perth already have a shortage of active playing fields. The research as Regional Open Space, this shortage can only get worse. Background Open space is an inherent part

  2. LLNL helps girls increase interest in STEM activities | National...

    National Nuclear Security Administration (NNSA)

    group activities along with 90-minute hands-on workshops in chemistry, biotechnology, computer science, engineering, environmental science and robotics. There also was a career...

  3. Supporting Information Unexpected Role of Activated Carbon in Promoting

    E-Print Network [OSTI]

    Huang, Ching-Hua

    Supporting Information Unexpected Role of Activated Carbon in Promoting Transformation of Secondary. (City of Industry, CA), Siemens Aquacarb carbon (AqC) from Siemens Water Technologies (Warrendale, PA

  4. STRUCTURAL AND TECTONIC CONTROLS OF GEOTHERMAL ACTIVITY IN THE...

    Open Energy Info (EERE)

    AND TECTONIC CONTROLS OF GEOTHERMAL ACTIVITY IN THE BASIN AND RANGE PROVINCE, WESTERN USA We are conducting an inventory of structural settings of geothermal systems (>400...

  5. Synthetic reverberating activity patterns embedded in networks of cortical neurons

    E-Print Network [OSTI]

    Roni Vardi; Avner Wallach; Evi Kopelowitz; Moshe Abeles; Shimon Marom; Ido Kanter

    2012-03-26T23:59:59.000Z

    Synthetic reverberating activity patterns are experimentally generated by stimulation of a subset of neurons embedded in a spontaneously active network of cortical cells in-vitro. The neurons are artificially connected by means of conditional stimulation matrix, forming a synthetic local circuit with a predefined programmable connectivity and time-delays. Possible uses of this experimental design are demonstrated, analyzing the sensitivity of these deterministic activity patterns to transmission delays and to the nature of ongoing network dynamics.

  6. Hydrodynamic effect on oil accumulation in a stratigraphic trap, Kitty Field, Powder River Basin, Wyoming

    E-Print Network [OSTI]

    Larberg, Gregory Martin

    1976-01-01T23:59:59.000Z

    stratigraphic traps in the Lower Cretaceous Muddy Sandstones on the east flank of the basin (Figure 1). The nine ? township area immediately surrounding Kitty in- cludes Kingsbury and Mill ? Gillette fields and is well ? suited for hydrodynamic study because... understanding of the relationships between pressures, flow, and the rocks themselves. 14 Nethods Subsurface data from the nine township area surround- ing Kitty field is abundant and readily available from in- dustry sources. Over 530 class "A" (analyzable...

  7. Active and reactive power in stochastic resonance for energy harvesting

    E-Print Network [OSTI]

    Kubota, Madoka; Hikihara, Takashi

    2015-01-01T23:59:59.000Z

    A power allocation to active and reactive power in stochastic resonance is discussed for energy harvesting from mechanical noise. It is confirmed that active power can be increased at stochastic resonance, in the same way of the relationship between energy and phase at an appropriate setting in resonance.

  8. Application of thermal analysis techniques in activated carbon production

    SciTech Connect (OSTI)

    Donnals, G.L.; DeBarr, J.A.; Brady, T.A. [Illinois State Geological Survey, Champaign, IL (United States)] [and others

    1996-12-31T23:59:59.000Z

    Several current research programs at the Illinois State Geological Survey (ISGS) relate to the development of activated carbons from Illinois coal, fly ash, and scrap tires. Preparation of activated carbons involves thermal processing steps that include preoxidation, pyrolysis and activation. Reaction time, temperature and gas composition during these processing steps ultimately determine the nature of the activated carbon produced. Thermal analysis plays a significant role in developing carbons by providing fundamental and engineering data that are useful in carbon production and characterization for process development.

  9. Economies of Size on Farms in the Blackland Area of Texas.

    E-Print Network [OSTI]

    Anderson, Carl G.; Moore, D. S.

    1972-01-01T23:59:59.000Z

    ........................................................................... Objectives 5 .................................................................... Area of Study 5 Concepts and Procedures ................................................ 6 Analytical Techniques .............................................. 6 Plant Sizes... per dollar farm sales. Short-run cost curves are developed of the five plant sizes, and an envelope or planning curve is fitted to the short-run larger than the three-man, six-row unit are not in- cluded in the analysis, it appears that average...

  10. Summary of ICTP activities in support of science in Uruguay

    E-Print Network [OSTI]

    Summary of ICTP activities in support of science in Uruguay 23/10/2013ICTP Public Information Office #12;*For the period 1970-1982, 3 visitors came from Uruguay; the total number of visitors is 195 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 ICTP Visitors from Uruguay, 1983

  11. Summary of ICTP activities in support of science in Libya

    E-Print Network [OSTI]

    Summary of ICTP activities in support of science in Libya June 19, 2013 0 ICTP Public Information Office #12;*For the period 1970-1982, 43 visitors came from Libya; the total number of visitors is 244 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 ICTP Visitors from Libya 1983-2012* Visitors

  12. Variation in serum alkaline phosphatase activity in cattle 

    E-Print Network [OSTI]

    Fletcher, Jesse Lane

    1956-01-01T23:59:59.000Z

    of variance of age-adjusted phosphatase in the dairy calves.............................................41 21. Classification of the Holstein cows on the basis of condi? tion of gestation and lactation........................... 42 22. Classification... of the Jersey cows on the basis of condition of gestation and lactation.................... ...........42 23. Estimates of heritability of phosphatase activity in Brahman cattle......................................... . 47 24. Estimates of heritability...

  13. Summary of ICTP activities in support of science in Haiti

    E-Print Network [OSTI]

    Summary of ICTP activities in support of science in Haiti 23/10/2013ICTP Public Information Office #12;} Scientific visitors from Haiti 35 (1996-2012), including 2 women } Haitian participation contribution to Haiti ICTP Marie Curie Library 400 items of scientific literature #12;} Haiti School

  14. Summary of ICTP activities in support of science in Bolivia

    E-Print Network [OSTI]

    Summary of ICTP activities in support of science in Bolivia 23/10/2013ICTP Public Information Office #12;*For the period 1970-1982, 20 visitors came from Bolivia; the total number of visitors is 78 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 ICTP Visitors from Bolivia, 1983-2012* Visitors

  15. Nucleotide Specificity versus Complex Heterogeneity in Exonuclease Activity Measurements

    E-Print Network [OSTI]

    Enderlein, Jörg

    Nucleotide Specificity versus Complex Heterogeneity in Exonuclease Activity Measurements Jo activity is nucleotide-dependent, and that a fluorescent label bound to a nucleotide significantly slows are fluorescently labeled at two specific sites in the nucleotide sequence (positions 5 and 38 from the free end

  16. Variation in serum alkaline phosphatase activity in cattle

    E-Print Network [OSTI]

    Fletcher, Jesse Lane

    1956-01-01T23:59:59.000Z

    the serum was stored, the analysis was completed within ten days of the date of collection of the blood sample. The serum alkaline phosphatase activity was determined 17 by the method of Bessy, Lowry, and Brock (194-6), in which 0.1 ml. of serum is used...

  17. Acoustic modes in combustors with complex impedances and multidimensional active

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Acoustic modes in combustors with complex impedances and multidimensional active flames F. Nicoud-acoustic modes in combustors. In the case of a non-isothermal reacting medium, the wave equation for the pressure

  18. Growing Up in Scotland: Year 3 - Food and Activity 

    E-Print Network [OSTI]

    Marryat, Louise; Valeria, Skafida; Webster, Catriona

    2009-01-21T23:59:59.000Z

    This report uses data from the Growing Up in Scotland study to explore the prevalence of, and many issues related to, food and activity in Scotland specifically in relation to young children....

  19. Drive torque actuation in active surge control of centrifugal compressors

    E-Print Network [OSTI]

    Gravdahl, Jan Tommy

    Drive torque actuation in active surge control of centrifugal compressors Jan Tommy Gravdahl , Olav to active surge control is presented for a centrifugal compressor driven by an electrical motor. The main is considered to be the control input. The proposed method is simulated on a compressor model using

  20. Transition Density, A Stochastic Measure of Activity in Digital Circuits

    E-Print Network [OSTI]

    Najm, Farid N.

    Transition Density, A Stochastic Measure of Activity in Digital Circuits Farid N. Najm.e., the rate at which its nodes are switching. We propose a new measure of activity, called the transition model of logic signals, we rigorously define the transition density and present an algorithm

  1. Transition Density, A Stochastic Measure of Activity in Digital Circuits

    E-Print Network [OSTI]

    Najm, Farid N.

    Transition Density, A Stochastic Measure of Activity in Digital Circuits Farid N. Najm.e., the rate at which its nodes are switching. We propose a new measure of activity, called the transition of logic signals, we rigorously de ne the transition density and present an algorithm to propagate it from

  2. Modeling and Optimizing Ergonomic Activities in Automobile Product Development

    E-Print Network [OSTI]

    da Silva, Alberto Rodrigues

    Modeling and Optimizing Ergonomic Activities in Automobile Product Development João Ferreira Anna.silva@acm.org Abstract We collect ergonomic rules and normative rules considerations for automobile business and modeled these activities with a special UML language created for automobile business, VDML (Vehicle Development Modeling

  3. Environments of deposition and diagenesis of the Jurassic Upper Smackover Formation in the Lincoln Parish area, Louisiana

    E-Print Network [OSTI]

    Palko, Gregory Jonathan

    1980-01-01T23:59:59.000Z

    of arasonite allochems and cements, leaching, precivita- tior. of' equant calcite meniscus and rim cements, mosaic ce- ment, coarse sparry calcite cement, commonly syrtaxial and po. '&ilo+opic, and solution compaction. Late diasenesis in- cludes... APPENDICES I-V. . . . ~ VI TA ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ -". 0 20 35 48 48 ~r 4 61 62 73 76 80 85 131 LISI' OF FIGURES FIGURE PAGE Ucoer Smackover lithofacies mac showing the distribution of the major facies...

  4. HANDLING UNCERTAINTY IN PRODUCTION ACTIVITY CONTROL USING PROACTIVE SIMULATION

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    HANDLING UNCERTAINTY IN PRODUCTION ACTIVITY CONTROL USING PROACTIVE SIMULATION Olivier CARDIN, Production Control, Manufacturing Systems, Proactive, Real-time. 1. INTRODUCTION In today's complex of a product. Real-word planning and scheduling problems are generally complex, constrained and multi

  5. Estimating electric current densities in solar active regions

    E-Print Network [OSTI]

    Wheatland, M S

    2015-01-01T23:59:59.000Z

    Electric currents in solar active regions are thought to provide the energy released via magnetic reconnection in solar flares. Vertical electric current densities $J_z$ at the photosphere may be estimated from vector magnetogram data, subject to substantial uncertainties. The values provide boundary conditions for nonlinear force- free modelling of active region magnetic fields. A method is presented for estimating values of $J_z$ taking into account uncertainties in vector magnetogram field values, and minimizing $J_z^2$ across the active region. The method is demonstrated using the boundary values of the field for a force-free twisted bipole, with the addition of noise at randomly chosen locations.

  6. Persistence of activity in noisy motor-filament assemblies

    E-Print Network [OSTI]

    Raghunath Chelakkot; Arvind Gopinath; L. Mahadevan

    2015-01-12T23:59:59.000Z

    Long, elastic filaments cross-linked and deformed by active molecular motors occur in various natural settings. The overall macroscopic mechanical response of such a composite network depends on the coupling between the active and the passive properties of the underlying constituents and nonlocal interactions between different parts of the composite. In a simple one dimensional system, using a mean field model, it has been shown that the combination of motor activity and finite filament extensibility yields a persistence length scale over which strain decays. Here we study a similar system, in the complementary limit of strong noise and moderate extensibility, using Brownian multi-particle collision dynamics-based numerical simulations that includes the coupling between motor kinetics and local filament extensibility. While the numerical model shows deviations from the mean field predictions due to the presence of strong active noise caused by the variations in individual motor activity, several qualitative features are still retained. Specifically, for fixed motor attachment and detachment rates, the decay is length is set by the ratio of the passive elasticity to the active shear resistance generated by attached motors. Our study generalizes the notion of persistence in passive thermal systems to actively driven systems with testable predictions.

  7. IN SITU REMEDIATION OF CONTAMINATED SEDIMENTS - ACTIVE CAPPING TECHNOLOGY

    SciTech Connect (OSTI)

    Knox, A.; Roberts, J.; Paller, M.; Reible, D.

    2010-09-02T23:59:59.000Z

    Active capping is a relatively new approach for treating contaminated sediments. It involves applying chemically reactive amendments to the sediment surface. The main role of active caps is to stabilize contaminants in contaminated sediments, lower the bioavailable pool of contaminants, and reduce the release of contaminants to the water column. Metals are common contaminants in many marine and fresh water environments as a result of industrial and military activities. The mobile, soluble forms of metals are generally considered toxic. Induced chemical precipitation of these metals can shift toxic metals from the aqueous phase to a solid, precipitated phase which is often less bioavailable. This approach can be achieved through application of sequestering agents such as rock phosphates, organoclays, zeolites, clay minerals, and biopolymers (e.g., chitosan) in active capping technology. Active capping holds great potential for a more permanent solution that avoids residual risks resulting from contaminant migration through the cap or breaching of the cap. In addition to identifying superior active capping agents, research is needed to optimize application techniques, application rates, and amendment combinations that maximize sequestration of contaminants. A selected set of active capping treatment technologies has been demonstrated at a few sites, including a field demonstration at the Savannah River Site, Aiken, SC. This demonstration has provided useful information on the effects of sequestering agents on metal immobilization, bioavailability, toxicity, and resistance to mechanical disturbance.

  8. Activation of ERK mitogen-activated protein kinase in human cells by the mycotoxin patulin

    SciTech Connect (OSTI)

    Wu, T.-S. [Department of Life Sciences, Chung Shan Medical University, No. 110, Sec. 1, Chien-Kuo N. Road, Taichung, Taiwan (China); Yu, F.-Y. [Department of Life Sciences, Chung Shan Medical University, No. 110, Sec. 1, Chien-Kuo N. Road, Taichung, Taiwan (China); Su, C.-C. [Tian-Sheng Memorial Hospital, Tong kong, Ping-Tong, Taiwan (China); Kan, J.-C. [Department of Life Sciences, Chung Shan Medical University, No. 110, Sec. 1, Chien-Kuo N. Road, Taichung, Taiwan (China); Chung, C.-P. [Department of Life Sciences, Chung Shan Medical University, No. 110, Sec. 1, Chien-Kuo N. Road, Taichung, Taiwan (China); Liu, B.-H. [Department of Life Sciences, Chung Shan Medical University, No. 110, Sec. 1, Chien-Kuo N. Road, Taichung, Taiwan (China)]. E-mail: bingliu@csmu.edu.tw

    2005-09-01T23:59:59.000Z

    Patulin (PAT), a mycotoxin produced by certain species of Penicillium and Aspergillus, is often detectable in moldy fruits and their derivative products. PAT led to a concentration-dependent and time-dependent increase in phosphorylation of extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) in human embryonic kidney (HEK293) cells, human peripheral blood mononuclear cells (PBMCs), and Madin-Darby canine kidney (MDCK) cells. Exposure of HEK293 cells to concentrations above 5 {mu}M PAT for 30 min induced ERK1/2 phosphorylation; activation of ERK1/2 was also observed after 24 h incubation with 0.05 {mu}M of PAT. Treatment of human PBMCs for 30 min with 30 {mu}M PAT dramatically increased the phosphorylated ERK1/2 levels. Both MEK1/2 inhibitors, U0126 and PD98059, suppressed ERK1/2 activation in either HEK293 or MDCK cells. In HEK293 cells, U0126-mediated inhibition of PAT-induced ERK1/2 phosphorylation resulted in a significant decrease in levels of DNA damage, expressed as tail moment values, in the single cell gel electrophoresis assay. Conversely, U0126 did not affect cell viability, lactate dehydrogenase release, and the DNA synthesis rate in PAT-treated cultures. Exposure of HEK293 cells for 90 min to 15 {mu}M PAT elevated the levels of early growth response gene-1 (egr-1) mRNA, but not of c-fos, fosB, and junB mRNAs. These results indicate that in human cells, PAT causes a rapid and persistent activation of ERK1/2 and this signaling pathway plays an important role in mediating PAT-induced DNA damage and egr-1 gene expression.

  9. Nonequilibrium equation of state in suspensions of active colloids

    E-Print Network [OSTI]

    Félix Ginot; Isaac Theurkauff; Demian Levis; Christophe Ybert; Lydéric Bocquet; Ludovic Berthier; Cécile Cottin-Bizonne

    2014-11-26T23:59:59.000Z

    Active colloids constitute a novel class of materials composed of colloidal-scale particles locally converting chemical energy into motility, mimicking micro-organisms. Evolving far from equilibrium, these systems display structural organizations and dynamical properties distinct from thermalized colloidal assemblies. Harvesting the potential of this new class of systems requires the development of a conceptual framework to describe these intrinsically nonequilibrium systems. We use sedimentation experiments to probe the nonequilibrium equation of state of a bidimensional assembly of active Janus microspheres, and conduct computer simulations of a model of self-propelled hard disks. Self-propulsion profoundly affects the equation of state, but these changes can be rationalized using equilibrium concepts. We show that active colloids behave, in the dilute limit, as an ideal gas with an activity-dependent effective temperature. At finite density, increasing the activity is similar to increasing adhesion between equilibrium particles. We quantify this effective adhesion and obtain a unique scaling law relating activity and effective adhesion in both experiments and simulations. Our results provide a new and efficient way to understand the emergence of novel phases of matter in active colloidal suspensions.

  10. Specific Examples of Global Activities Environmental assessment in Azerbaijan

    E-Print Network [OSTI]

    , global warming, and global entrepreneurship. Discovery Park works syner- gistically with the Office competitiveness, global energy security, global warming, and global entrepreneurship. Discovery Park worksSpecific Examples of Global Activities · Environmental assessment in Azerbaijan · Study abroad

  11. Minimizing High Spatial Frequency Residual in Active Space Telescope Mirrors

    E-Print Network [OSTI]

    . Miller June 2008 SSL # 4-08 #12;#12;Minimizing High Spatial Frequency Residual in Active Space Telescope Mirrors Thomas Gray, David W. Miller June 2008 SSL # 4-08 This work is based on the unaltered text

  12. The variability of warm absorbers in Active Galactic Nuclei

    E-Print Network [OSTI]

    Gibson, Robert R. (Robert Ross)

    2006-01-01T23:59:59.000Z

    This thesis presents three studies of warm (photoionized) absorber variability in Active Galactic Nuclei (AGN) using high-resolution X-ray spectra provided by the Chandra High Energy Transmission Grating (HETG). The first ...

  13. Conducting polymers as potential active materials in electrochemical supercapacitors

    SciTech Connect (OSTI)

    Rudge, A.; Davey, J.; Raistrick, I.; Gottesfeld, S. [Los Alamos National Lab., NM (United States); Ferraris, J.P. [Texas Univ., Richardson, TX (United States). Dept. of Chemistry

    1992-12-01T23:59:59.000Z

    Electronically,conducting polymers represent an interesting class of materials for use in electrochemical capacitors because of the combination of high capacitive energy density and low materials cost. Three generalized types of electrochemical capacitors can be constructed using conducting polymers as active material, and in the third of these, which utilizes conducting polymers that can be both n- and p-doped, energy densities of up to 40 watt-hours per kilogram of active material on both electrodes have been demonstrated.

  14. Conducting polymers as potential active materials in electrochemical supercapacitors

    SciTech Connect (OSTI)

    Rudge, A.; Davey, J.; Raistrick, I.; Gottesfeld, S. (Los Alamos National Lab., NM (United States)); Ferraris, J.P. (Texas Univ., Richardson, TX (United States). Dept. of Chemistry)

    1992-01-01T23:59:59.000Z

    Electronically,conducting polymers represent an interesting class of materials for use in electrochemical capacitors because of the combination of high capacitive energy density and low materials cost. Three generalized types of electrochemical capacitors can be constructed using conducting polymers as active material, and in the third of these, which utilizes conducting polymers that can be both n- and p-doped, energy densities of up to 40 watt-hours per kilogram of active material on both electrodes have been demonstrated.

  15. Propagation of Uncertainty in Chemically Activated Systems

    E-Print Network [OSTI]

    Androulakis, Ioannis (Yannis)

    in internal combustion engines. A distinguishing feature of the low-temperature chemistry of many molecules

  16. The geometry and topology of turbulence in active nematics

    E-Print Network [OSTI]

    Luca Giomi

    2014-09-04T23:59:59.000Z

    The problem of low Reynolds number turbulence in active nematic fluids is theoretically addressed. Using numerical simulations I demonstrate that an incompressible turbulent flow, in two-dimensional active nematics, consists of an ensemble of vortices whose areas are exponentially distributed within a range of scales. Building on this evidence, I construct a mean-field theory of active turbulence by which several measurable quantities, including the spectral densities and the correlation functions, can be analytically calculated. Due to the profound connection between the flow geometry and the topological properties of the nematic director, the theory sheds light on the mechanisms leading to the proliferation of topological defects in active nematics and provides a number of testable predictions. A hypothesis, inspired by Onsager's statistical hydrodynamics, is finally introduced to account for the equilibrium probability distribution of the vortex sizes.

  17. Long-lived activation products in reactor materials

    SciTech Connect (OSTI)

    Evans, J.C.; Lepel, E.L.; Sanders, R.W.; Wilkerson, C.L.; Silker, W.; Thomas, C.W.; Abel, K.H.; Robertson, D.R.

    1984-08-01T23:59:59.000Z

    The purpose of this program was to assess the problems posed to reactor decommissioning by long-lived activation products in reactor construction materials. Samples of stainless steel, vessel steel, concrete, and concrete ingredients were analyzed for up to 52 elements in order to develop a data base of activatable major, minor, and trace elements. Large compositional variations were noted for some elements. Cobalt and niobium concentrations in stainless steel, for example, were found to vary by more than an order of magnitude. A thorough evaluation was made of all possible nuclear reactions that could lead to long lived activation products. It was concluded that all major activation products have been satisfactorily accounted for in decommissioning planning studies completed to date. A detailed series of calculations was carried out using average values of the measured compositions of the appropriate materials to predict the levels of activation products expected in reactor internals, vessel walls, and bioshield materials for PWR and BWR geometries. A comparison is made between calculated activation levels and regulatory guidelines for shallow land disposal according to 10 CFR 61. This analysis shows that PWR and BWR shroud material exceeds the Class C limits and is, therefore, generally unsuitable for near-surface disposal. The PWR core barrel material approaches the Class C limits. Most of the remaining massive components qualify as either Class A or B waste with the bioshield clearly Class A, even at the highest point of activation. Selected samples of activated steel and concrete were subjected to a limited radiochemical analysis program as a verification of the computer model. Reasonably good agreement with the calculations was obtained where comparison was possible. In particular, the presence of /sup 94/Nb in activated stainless steel at or somewhat above expected levels was confirmed.

  18. Sign inRegister Recent Activity

    E-Print Network [OSTI]

    Glaser, Rainer

    more efficient and safer for those living near, and working in, treated fields. Ads by Google Honda's Innovative Films - Honda shares its belief in the Power of Dreams. Watch here. - www.honda.com Methyl iodide

  19. United Nations geothermal activities in developing countries

    SciTech Connect (OSTI)

    Beredjick, N.

    1987-07-01T23:59:59.000Z

    The United Nations implements technical cooperation projects in developing countries through its Department of Technical Cooperation for Development (DTCD). The DTCD is mandated to explore for and develop natural resources (water, minerals, and relevant infrastructure) and energy - both conventional and new and renewable energy sources. To date, the United Nations has been involved in over 30 geothermal exploration projects (completed or underway) in 20 developing countries: 8 in Africa (Djibouti, Ethiopia, Kenya, Madagascar); 8 in Asia (China, India, Jordan, Philippines, Thailand); 9 in Latin America (Bolivia, Chile, El Salvador, Honduras, Mexico, Nicaragua, Panama) and 6 in Europe (Greece, Romania, Turkey, Yugoslavia). Today, the DTCD has seven UNDP geothermal projects in 6 developing countries. Four of these (Bolivia, China, Honduras, and Kenya) are major exploration projects whose formulation and execution has been possible thanks to the generous contributions under cost-sharing arrangements from the government of Italy. These four projects are summarized.

  20. Autophagic activity in neuronal cell death

    E-Print Network [OSTI]

    Button, Robert W.; Luo, Shouqing; Rubinsztein, David C.

    2015-06-15T23:59:59.000Z

     malignancies.  Autophagy,  2009.  5(8):  p.  1198-­?200.  83.   Laane,  E.,  et  al.,  Cell  death  induced  by  dexamethasone  in  lymphoid  leukemia  is  mediated  through  initiation  of  autophagy.  Cell... .  308-­?16.  103.   Wu,  X.,  et  al.,  Impaired  autophagy  contributes  to  adverse  cardiac  remodeling  in  acute  myocardial  infarction.  PLoS  One,  2014.  9(11):  p.  e112891.  104.   Wu,  F...

  1. Visible Light Communications: Recent Activities in Japan

    E-Print Network [OSTI]

    Lü, James Jian-Qiang

    The Graduate School of System Design and Management, Keio University, Yokohama, Japan Smart Spaces: A Smart, visible light LEDs are beginning to be used in every home and office, which makes visible light LEDs ideal, and the market share of LED lighting will be more than 30 percent of total lighting market in 2016. Prediction

  2. Ethylene Market Activity in the 1990s

    E-Print Network [OSTI]

    Field, S.; McCormack, G.

    scenario will not change. OverlY ambitious capacity bUilding which occurred in the late 1970s. combined wIth industrial slagnation In the early 1980s produced overcapacity, miserable pr"ofi ts and the industry shakeout whIch was experienced....e-by""site analYSIS indicate that. ethylene capacity willgro~ b 5-7 %/year. The supply prOjectIon are more predIctable lhan the growth projectIons. If both projections hold UP. price erosion will continue. result~nq in poor t no pr"ofits for' d new plant...

  3. Taxation of oil and gas activities in Spain

    SciTech Connect (OSTI)

    Anton, F.L.

    1984-09-01T23:59:59.000Z

    Special tax norms in Spain deal with the exploration, drilling, production, and distribution of oil and gas companies that set them apart from the activities of other companies doing business. A review of the Corporation Tax, Turnover Tax, and taxes related to exploration, provincial and local tax exemptions, importations, withholding obligations, and other activities concludes that the oil and gas industries benefit more than they would under the general tax system. 33 references.

  4. Ion pump activity generates fluctuating electrostatic forces in biomembranes

    E-Print Network [OSTI]

    B. Loubet; M. A. Lomholt

    2011-09-19T23:59:59.000Z

    We study the non-equilibrium dynamics of lipid membranes with proteins that actively pump ions across the membrane. We find that the activity leads to a fluctuating force distribution due to electrostatic interactions arising from variation in dielectric constant across the membrane. By applying a multipole expansion we find effects on both the tension and bending rigidity dominated parts of the membranes fluctuation spectrum. We discuss how our model compares with previous studies of force-multipole models.

  5. Magnetic Activity in Stars, Discs and Quasars

    E-Print Network [OSTI]

    Donald Lynden-Bell

    2000-07-14T23:59:59.000Z

    Although magnetic fields in interstellar matter were postulated almost fifty years ago, magnetohydrodynamic theory was then much hampered by our inability to see what the magnetic field configurations were like and, after a decade of innovative development, cynics, not without some justification, began to claim that anything can happen when magnetism and an imaginative theorist get together. Thus cosmic lightning in particular received a bad press. More recently great advances in observational techniques that we shall hear of from Title, Beck, Moran and Mirabel have enabled us to see not only the sun's magnetic field with unprecedented clarity but the fields in galaxies, quasars and microquasars are now measured and not merely figments of fertile imaginations.

  6. Hypoxia activated cell signaling receptors in cancer

    E-Print Network [OSTI]

    Lester, Robin D.

    2008-01-01T23:59:59.000Z

    cancer cells MCF-7 and MDA- MB-231. Biomed. Pharmacother.and prevents apoptosis in MDA-MB-231 breast cancer cells. J.Gaithersburg, MD). Cell Culture MDA-MB-468, MDA-MB-435, ZR-

  7. OBSERVING CORONAL NANOFLARES IN ACTIVE REGION MOSS

    SciTech Connect (OSTI)

    Testa, Paola; DeLuca, Ed; Golub, Leon; Korreck, Kelly; Weber, Mark [Smithsonian Astrophysical Observatory, 60 Garden street, MS 58, Cambridge, MA 02138 (United States); De Pontieu, Bart; Martinez-Sykora, Juan; Title, Alan [Lockheed Martin Solar and Astrophysics Lab, Org. A021S, Bldg. 252, 3251 Hanover Street, Palo Alto, CA 94304 (United States); Hansteen, Viggo [Institute of Theoretical Astrophysics, University of Oslo, P.O. Box 1029 Blindern, N-0315 Oslo (Norway); Cirtain, Jonathan; Winebarger, Amy; Kobayashi, Ken [NASA Marshall Space Flight Center, ZP 13, Huntsville, AL 35812 (United States); Kuzin, Sergey [P. N. Lebedev Physical institute of the Russian Academy of Sciences, Leninskii prospekt, 53, 119991 Moscow (Russian Federation); Walsh, Robert [University of Central Lancashire, Lancashire, Preston PR1 2HE (United Kingdom); DeForest, Craig, E-mail: ptesta@cfa.harvard.edu [Southwest Research Institute, 1050 Walnut Street, Suite 300, Boulder, CO 80302 (United States)

    2013-06-10T23:59:59.000Z

    The High-resolution Coronal Imager (Hi-C) has provided Fe XII 193A images of the upper transition region moss at an unprecedented spatial ({approx}0.''3-0.''4) and temporal (5.5 s) resolution. The Hi-C observations show in some moss regions variability on timescales down to {approx}15 s, significantly shorter than the minute-scale variability typically found in previous observations of moss, therefore challenging the conclusion of moss being heated in a mostly steady manner. These rapid variability moss regions are located at the footpoints of bright hot coronal loops observed by the Solar Dynamics Observatory/Atmospheric Imaging Assembly in the 94 A channel, and by the Hinode/X-Ray Telescope. The configuration of these loops is highly dynamic, and suggestive of slipping reconnection. We interpret these events as signatures of heating events associated with reconnection occurring in the overlying hot coronal loops, i.e., coronal nanoflares. We estimate the order of magnitude of the energy in these events to be of at least a few 10{sup 23} erg, also supporting the nanoflare scenario. These Hi-C observations suggest that future observations at comparable high spatial and temporal resolution, with more extensive temperature coverage, are required to determine the exact characteristics of the heating mechanism(s).

  8. Active Brownian motion in a narrow channel

    E-Print Network [OSTI]

    Xue Ao; Pulak Kumar Ghosh; Yunyun Li; Gerhard Schmid; Peter Hänggi; Fabio Marchesoni

    2014-09-17T23:59:59.000Z

    We review recent advances in rectification control of artificial microswimmers, also known as Janus particles, diffusing along narrow, periodically corrugated channels. The swimmer self-propulsion mechanism is modeled so as to incorporate a nonzero torque (propulsion chirality). We first summarize the effects of chirality on the autonomous current of microswimmers freely diffusing in channels of different geometries. In particular, left-right and upside-down asymmetric channels are shown to exhibit different transport properties. We then report new results on the dependence of the diffusivity of chiral microswimmers on the channel geometry and their own self-propulsion mechanism. The self-propulsion torque turns out to play a key role as a transport control parameter.

  9. Process for reducing beta activity in uranium

    DOE Patents [OSTI]

    Briggs, Gifford G. (Cincinnatti, OH); Kato, Takeo R. (Cincinnatti, OH); Schonegg, Edward (Cleves, OH)

    1986-01-01T23:59:59.000Z

    This invention is a method for lowering the beta radiation hazards associated with the casting of uranium. The method reduces the beta radiation emitted from the as-cast surfaces of uranium ingots. The method also reduces the amount of beta radiation emitters retained on the interiors of the crucibles that have been used to melt the uranium charges and which have undergone cleaning in a remote handling facility. The lowering of the radioactivity is done by scavenging the beta emitters from the molten uranium with a molten mixture containing the fluorides of magnesium and calcium. The method provides a means of collection and disposal of the beta emitters in a manner that reduces radiation exposure to operating personnel in the work area where the ingots are cast and processed.

  10. Process for reducing beta activity in uranium

    DOE Patents [OSTI]

    Briggs, G.G.; Kato, T.R.; Schonegg, E.

    1985-04-11T23:59:59.000Z

    This invention is a method for lowering the beta radiation hazards associated with the casting of uranium. The method reduces the beta radiation emitted from the as-cast surfaces of uranium ingots. The method also reduces the amount of beta radiation emitters retained on the interiors of the crucibles that have been used to melt the uranium charges and which undergone cleaning in a remote handling facility. The lowering of the radioactivity is done by scavenging the beta emitters from the molten uranium with a molten mixture containing the fluorides of magnesium and calcium. The method provides a means of collection and disposal of the beta emitters in a manner that reduces radiation exposure to operating personnel in the work area where the ingots are cast and processed. 5 tabs.

  11. Techniques in Active and Generic Software Libraries

    E-Print Network [OSTI]

    Smith, Jacob N.

    2010-07-14T23:59:59.000Z

    at the end of a multiyear journey into computer science ? especially software engineering and the development of software libraries. I would like to thank my adviser Dr. Jaakko J?arvi first and foremost. Little does he know that it was reading his papers (and... managed to actually work on a project together. Hand-in-hand I would like to thank everyone in Dr. Bjarne Stroustrup?s lab (including Bjarne for being such a good sport): Luke Wagner for helping me to understand logic and language theory; Yuriy Solodkyy...

  12. Active vibration control in a microgravity environment

    E-Print Network [OSTI]

    Park, Myoung Soo

    1987-01-01T23:59:59.000Z

    . 4046 K Because Uf is proportional to ?, , x term in above equation cancels out. Therei'ore Jf has a constant value under the assumption of a constant air jet pressure. From equation (38), 1 Jf = Jf = ? wD pUp 0 4 (42) In order to use equation (42.... 6 (Andersen, 1967), the final velocity is found (Figure 13), (APPENDIX B). 1 2k Pi Us = I( )[I ? ( ? ) )( ? )I k ? 1 P, pi (43) Now using'equations (42) and (43), calculated thrust force produced by jet. As 1 Jf = ? ?wD pUs As 4 (44) 28...

  13. Constraining initial 230 Th activity in incrementally

    E-Print Network [OSTI]

    Miami, University of

    seawater has been estimated from incrementally deposited aragonite skeletons of sclerosponges using U) to 75,690 y (230 Th), are continuously produced by decay of aqueous uranium, and primordial 232 Th et al., 1957; Kaufman, 1969; Moore, 1981), the con- centration of thorium in seawater had been nearly

  14. Sign inRegister Recent Activity

    E-Print Network [OSTI]

    Espinosa, Horacio D.

    Sponsored account About us More Search advanced search Science and technology news Home Nanotechnology mechanical energy (such as biomechanical motion) to electrical energy. "Although nanowires are one piezoelectric behavior in 3D up to six times of their bulk counterpart. Since the generated charge scales

  15. Active mode-locking in semiconductor lasers

    E-Print Network [OSTI]

    Lee, Yong-Hun

    1990-01-01T23:59:59.000Z

    bias: 254 mA p-p, horizontal scale: second, and vertical scale: number per ttm3). 10 4000 3000 2000 1000 Q+ Q~ O' Q+ Q Q Q Q Q Q Q QQS QQS QQS QQS QQS QQS QQ 6 to its 6 1 . l 1 QQ &~Q ~QQ 1' QQQ &SQ eQQ Fig. 4. Computer simulated photon... signal drive. From the Table I (vertical scale: arbitrary in voltage unit, horizontal span: 500 ps). 40 200 150 100 50 -50 -100 -150 Q~ Q~ ~QQ Q~ Q~ QQ~ QS QQ~ QQS QQ QQ QQ QQ QQ QQ Q. Q. Q. Q Q. gQ qQ QQ qQ ~Q Fig. 26. The inverse fourier...

  16. IMPROVEMENT OF METHANE STORAGE IN ACTIVATED CARBON USING METHANE HYDRATE

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    it to a gas hydrate formation. In fact, the gas hydrate formation in the remaining free porosity after manuscript, published in "Fifth International Conference on Gas Hydrates (ICGH 5),, Tromdheim : Norway (2005IMPROVEMENT OF METHANE STORAGE IN ACTIVATED CARBON USING METHANE HYDRATE M.L. Zanota(1) , L. Perier

  17. MAGNETIC ACTIVITY CYCLES IN THE EXOPLANET HOST STAR {epsilon} ERIDANI

    SciTech Connect (OSTI)

    Metcalfe, T. S.; Mathur, S. [Space Science Institute, 4750 Walnut Street, Suite 205, Boulder, CO 80301 (United States); Buccino, A. P.; Mauas, P. J. D.; Petrucci, R. [Instituto de Astronomia y Fisica del Espacio (CONICET), C.C. 67 Sucursal 28, C1428EHA-Buenos Aires (Argentina); Brown, B. P. [Department of Astronomy and Center for Magnetic Self-Organization, University of Wisconsin, Madison, WI 53706-1582 (United States); Soderblom, D. R. [Space Telescope Science Institute, 3700 San Martin Dr., Baltimore, MD 21218 (United States); Henry, T. J. [Department of Physics and Astronomy, Georgia State University, Atlanta, GA 30302 (United States); Hall, J. C. [Lowell Observatory, 1400 West Mars Hill Road, Flagstaff, AZ 86001 (United States); Basu, S. [Department of Astronomy, Yale University, P.O. Box 208101, New Haven, CT 06520 (United States)

    2013-02-01T23:59:59.000Z

    The active K2 dwarf {epsilon} Eri has been extensively characterized both as a young solar analog and more recently as an exoplanet host star. As one of the nearest and brightest stars in the sky, it provides an unparalleled opportunity to constrain stellar dynamo theory beyond the Sun. We confirm and document the 3-year magnetic activity cycle in {epsilon} Eri originally reported by Hatzes and coworkers, and we examine the archival data from previous observations spanning 45 years. The data show coexisting 3-year and 13-year periods leading into a broad activity minimum that resembles a Maunder minimum-like state, followed by the resurgence of a coherent 3-year cycle. The nearly continuous activity record suggests the simultaneous operation of two stellar dynamos with cycle periods of 2.95 {+-} 0.03 years and 12.7 {+-} 0.3 years, which, by analogy with the solar case, suggests a revised identification of the dynamo mechanisms that are responsible for the so-called 'active' and 'inactive' sequences as proposed by Boehm-Vitense. Finally, based on the observed properties of {epsilon} Eri, we argue that the rotational history of the Sun is what makes it an outlier in the context of magnetic cycles observed in other stars (as also suggested by its Li depletion), and that a Jovian-mass companion cannot be the universal explanation for the solar peculiarities.

  18. Measurements of Microbial Community Activities in Individual Soil Macroaggregates

    SciTech Connect (OSTI)

    Bailey, Vanessa L.; Bilskis, Christina L.; Fansler, Sarah J.; McCue, Lee Ann; Smith, Jeff L.; Konopka, Allan

    2012-05-01T23:59:59.000Z

    The functional potential of single soil aggregates may provide insights into the localized distribution of microbial activities better than traditional assays conducted on bulk quantities of soil. Thus, we scaled down enzyme assays for {beta}-glucosidase, N-acetyl-{beta}-D-glucosaminidase, lipase, and leucine aminopeptidase to measure of the enzyme potential of individual aggregates (250-1000 {mu}m diameter). Across all enzymes, the smallest aggregates had the greatest activity and the range of enzyme activities observed in all aggregates supports the hypothesis that functional potential in soil may be distributed in a patchy fashion. Paired analyses of ATP as a surrogate for active microbial biomass and {beta}-glucosidase on the same aggregates suggest the presence of both extracellular {beta}-glucosidase functioning in aggregates with no detectable ATP and also of relatively active microbial communities (high ATP) that have low {beta}-glucosidase potentials. Studying function at a scale more consistent with microbial habitat presents greater opportunity to link microbial community structure to microbial community function.

  19. Metabolic and Electrical Oscillations: Partners in Controlling Rhythmic Islet Activity

    E-Print Network [OSTI]

    Bertram, Richard

    Bursting Oscillations Simultaneous fast Ca2+ and voltage measurements from a mouse islet in 11.1 mM glucose+ and voltage from an islet... ...have period similar to slow insulin oscillations measured from a mouse in vivoMetabolic and Electrical Oscillations: Partners in Controlling Rhythmic Islet Activity Richard

  20. Experimental Studies of Active Temperature Control in Solid Breeder Blankets

    E-Print Network [OSTI]

    Tillack, Mark

    1 Experimental Studies of Active Temperature Control in Solid Breeder Blankets M. S. Tillack, A. R barrier regions for solid breeder blankets. In particular, particle beds have been studied because breeder blankets is thermomechanical behavior in the fusion environment. Stable and predictable

  1. Oculomotor Responses to Active Head Movements in Darkness

    E-Print Network [OSTI]

    Ramat, Stefano

    information on head rotation from the vestibular system to the saccade-generating mechanism in the brain stem482 Oculomotor Responses to Active Head Movements in Darkness Formulation and Testing Sistemistica, Università di Pavia, Pavia, Italy Passive head rotation in darkness produces vestibular nystagmus

  2. Active Perception in Virtual Humans Tamer F. Rabie Demetri Terzopoulos

    E-Print Network [OSTI]

    Terzopoulos, Demetri

    Active Perception in Virtual Humans Tamer F. Rabie Demetri Terzopoulos Department of Electrical prescribes artificial animals, or animats, situated in physics- based virtual worlds as autonomous virtual a pro- totype animat vision implementation within realistic virtual human soldiers situated in a virtual

  3. Cortical Activation During Spatiotemporal Processing in the Infant Brain

    E-Print Network [OSTI]

    Armstrong, Jennifer R.

    2010-01-14T23:59:59.000Z

    .5 months, infants are sensitive to spatiotemporal information for object individuation in occlusion events. This study used Near Infrared Spectroscopy to assess neural activation (as evidenced by an increase in HbO2) in four areas of the pathways: primary...

  4. Studies on the activities of rumen microorganisms in vitro

    E-Print Network [OSTI]

    Johnson, Carl Edward

    1957-01-01T23:59:59.000Z

    STCDIES ON THE ACTIVITIES OF RUMEN MICROORGANISMS IN VITRO A Thesis Carl~Johnson Submitted to the, Gr;. dusts School of the Agricultural and Mec?anical Co13 cgs oi' Texas in partial fulfillment of the requirements for the degree of MAST'% OS... SCIENCE August 1)57 Major Subject: Animal Nutrition STUDIES CN THE ACTIVITIES OF RUNEN MICROORGANISMS IN VITRO A Thesis Carl Johnson Approved as to style and oontent b Cha of Committee Head of Department August 1957 ACIQIOWLEDGMENTS The author...

  5. Nuclear Activity in UZC Compact Groups of Galaxies

    E-Print Network [OSTI]

    M. A. Martinez; A. del Olmo; P. Focardi; J. Perea

    2006-11-02T23:59:59.000Z

    We analyse the level of nuclear activity in galaxies belonging to UZC-CGs. Spectra are available for 868 galaxies (90% of the whole catalog); 67 % of them show nuclear activity (AGN or Star formation). To carry out a detailed study about the nuclear activity and its relationship with properties of the host galaxy and parent group we select a sample of 215 groups with spectra available for all their members. From the analysis of this sample and using diagnostic diagrams to do the nuclear classification we found that 37% of emission galaxies host an HII nuclear region, 43% an AGN and 20% a Transition Object. AGNs are located mainly in bright early type galaxies meanwhile HII are in fainter and later types. Groups dominated by HII show significant lower velocity dispersions and larger sizes than groups dominated by AGNs or TO.

  6. Representing cognitive activities and errors in HRA trees

    SciTech Connect (OSTI)

    Gertman, D.I.

    1992-01-01T23:59:59.000Z

    A graphic representation method is presented herein for adapting an existing technology--human reliability analysis (HRA) event trees, used to support event sequence logic structures and calculations--to include a representation of the underlying cognitive activity and corresponding errors associated with human performance. The analyst is presented with three potential means of representing human activity: the NUREG/CR-1278 HRA event tree approach; the skill-, rule- and knowledge-based paradigm; and the slips, lapses, and mistakes paradigm. The above approaches for representing human activity are integrated in order to produce an enriched HRA event tree -- the cognitive event tree system (COGENT)-- which, in turn, can be used to increase the analyst's understanding of the basic behavioral mechanisms underlying human error and the representation of that error in probabilistic risk assessment. Issues pertaining to the implementation of COGENT are also discussed.

  7. Representing cognitive activities and errors in HRA trees

    SciTech Connect (OSTI)

    Gertman, D.I.

    1992-05-01T23:59:59.000Z

    A graphic representation method is presented herein for adapting an existing technology--human reliability analysis (HRA) event trees, used to support event sequence logic structures and calculations--to include a representation of the underlying cognitive activity and corresponding errors associated with human performance. The analyst is presented with three potential means of representing human activity: the NUREG/CR-1278 HRA event tree approach; the skill-, rule- and knowledge-based paradigm; and the slips, lapses, and mistakes paradigm. The above approaches for representing human activity are integrated in order to produce an enriched HRA event tree -- the cognitive event tree system (COGENT)-- which, in turn, can be used to increase the analyst`s understanding of the basic behavioral mechanisms underlying human error and the representation of that error in probabilistic risk assessment. Issues pertaining to the implementation of COGENT are also discussed.

  8. Proton induced activation in mercury: Comparison of measurements and calculations

    SciTech Connect (OSTI)

    Remec, Igor [ORNL; Glasgow, David C [ORNL; Haines, John R [ORNL; Johnson, Jeffrey O [ORNL

    2008-01-01T23:59:59.000Z

    Measurements and simulations of the proton beam interaction with the mercury target were performed to support Spallation Neutron Source design. Due to the abundance of isotopes produced in mercury, the long delay between the irradiation and the measurements, and the self-shielding of the mercury sample, the measurements were difficult to perform and the activities of several isotopes have large uncertainties. Calculations predicted the activities of the most reliably measured isotopes within 20%/40%; however, some large discrepancies were observed for some isotopes for which the measurements were considered less reliable. Predicted dose rates were in very good agreement with the measurements.

  9. Phase Separation and Emergent Structures in an Active Nematic

    E-Print Network [OSTI]

    Elias Putzig; Aparna Baskaran

    2014-09-03T23:59:59.000Z

    We consider a phenomenological continuum model for an active nematic fluid and show a universal, model independent, instability which renders the homogeneous nematic state unstable to order fluctuations. Using numerical and analytic tools we show that, for low energy excitations in the vicinity of a critical point, this instability leads to a phase separation in which the ordered regions form bands with the direction of nematic order being perpendicular to the direction of density gradient. We argue that this mechanism of phase separation, which we term self-regulation, is a universal feature of active fluids.

  10. Innovative Liquid Breeder Blanket Design Activities in Japan

    SciTech Connect (OSTI)

    Sagara, Akio [National Institute for Fusion Science (Japan); Tanaka, Teruya [National Institute for Fusion Science (Japan); Muroga, Takeo [National Institute for Fusion Science (Japan); Hashizume, Hidetoshi [Tohoku University (Japan); Kunugi, Tomoaki [Kyoto University (Japan); Fukada, Satoshi [Kyushu University (Japan); Shimizu, Akihiko [Kyushu University (Japan)

    2005-04-15T23:59:59.000Z

    In order to clarify key engineering issues and to enhance key R and D activities for D-T fusion blankets, many design activities on innovative liquid blanket systems are on going as collaboration studies in Japan. Recently an improved long-life Flibe blanket has been proposed, and the self-cooled Li/V blanket design has started. For Flibe systems, much progress has been made on tritium permeation barrier, energy conversion system, free surface designs, and thermofluid loop experiments. For Li/V systems, evaluation studies have proceeded on Be-free nuclear properties and allowable crack fraction on multilayered MHD insulation coatings.

  11. Proton Diffusion in Nickel Hydroxide Prediction of Active Material Utilization

    E-Print Network [OSTI]

    Weidner, John W.

    to improve battery design and operation. Introduction Nickel hydroxide is the active material in rechargeable of protons, we used elec- trochemical impedance spectroscopy to measure D+ in planar nickel hydroxide films nickel batteries (e.g., Ni/Cd, Ni/Zn, and Ni/H2). Nickel batteries are usually positive limited, meaning

  12. H2 R&D Activities in the Nordic Countries

    E-Print Network [OSTI]

    R&D Activities in the Nordic Countries Department: Department of Systems Analysis, Risø National is given on the R&D projects at national, EU and Nordic levels. Risø National Laboratory Information National Research in Hydrogen and Fuel Cells 6 3.1 Danish H2 Energy R&D 6 3.2 Finnish H2 related R&D 7 3

  13. Shock wave propagation in composites and active Vinamra Agrawal

    E-Print Network [OSTI]

    Shyamasundar, R.K.

    Shock wave propagation in composites and active Vinamra Agrawal California Institute of Technology travel through a material. These waves are characterized as a discontinuity propagating through shock waves propagate in heterogeneous materials. Shock waves are also being used to o pulsed currents

  14. Active load alleviation is getting more and more important in

    E-Print Network [OSTI]

    Langendoen, Koen

    energy. Nowadays modern aircraft and wind turbine blades are equipped with means to actively alleviate rotating and stationary parts of the windmill, is easier. As the wind turbine blades rotate, in prior state of the windmill construction. Weight reduction As there is no more need for a large actuator in the turbine blade

  15. Modeling active electrolocation in weakly electric fish Habib Ammari

    E-Print Network [OSTI]

    Garnier, Josselin

    Modeling active electrolocation in weakly electric fish Habib Ammari Thomas Boulier Josselin in weakly electric fishes. We first investigate the forward complex conductivity problem and derive the approx- imate boundary conditions on the skin of the fish. Then we provide a dipole approximation

  16. Argonne National Laboratory has been actively involved in the development

    E-Print Network [OSTI]

    Kemner, Ken

    Argonne National Laboratory has been actively involved in the development of advanced batteries at Argonne and named it the National Battery Test Laboratory (NBTL), for the purpose of conducting in these early days of the battery program, Argonne was internationally respected for its advanced battery work

  17. Movements and activities of snow leopards in Southwestern Mongolia

    E-Print Network [OSTI]

    Schweik, Charles M.

    Movements and activities of snow leopards in Southwestern Mongolia Thomas M. McCarthy a,*, Todd K.O. Box 1160, Ulaanbaatar, Mongolia Received 18 September 2004 Abstract Four adult (2M:2F) snow leopards in the Altai Mountains of southwestern Mongolia where prey densities (i.e., ibex, Capra siberica) were

  18. Cellular/Molecular Detecting Activity in Olfactory Bulb Glomeruli with

    E-Print Network [OSTI]

    Newman, Eric A.

    Cellular/Molecular Detecting Activity in Olfactory Bulb Glomeruli with Astrocyte Recording Didier, Oregon 97239 In the olfactory bulb, axons of olfactory sensory neurons (OSNs) expressing the same to examine functional compartmentalization within and between olfactory bulb glomeruli. Key words: olfactory

  19. Defects activated photoluminescence in two-dimensional semiconductors

    E-Print Network [OSTI]

    Wu, Junqiao

    Defects activated photoluminescence in two-dimensional semiconductors: interplay between bound of Semiconductors, Chinese Academy of Sciences, P.O. Box 912, Beijing 100083, People's Republic of China, 3, Berkeley, California 94720, United States. Point defects in semiconductors can trap free charge carriers

  20. Conditional Random Fields for Activity Recognition in Smart Environments

    E-Print Network [OSTI]

    Cook, Diane J.

    recognition. Our focus is on using CRFs to recognize activities performed by an inhabitant in a smart home with HMMs using data collected in a real smart home. Categories and Subject Descriptors I.2.6 [Computing. The Georgia Tech Aware Home [3] identifies people based on pressure sensors embedded into the smart floor

  1. Quantitative genetic activity graphical profiles for use in chemical evaluation

    SciTech Connect (OSTI)

    Waters, M.D. [Environmental Protection Agency, Washington, DC (United States); Stack, H.F.; Garrett, N.E.; Jackson, M.A. [Environmental Health Research and Testing, Inc., Research Triangle Park, NC (United States)

    1990-12-31T23:59:59.000Z

    A graphic approach, terms a Genetic Activity Profile (GAP), was developed to display a matrix of data on the genetic and related effects of selected chemical agents. The profiles provide a visual overview of the quantitative (doses) and qualitative (test results) data for each chemical. Either the lowest effective dose or highest ineffective dose is recorded for each agent and bioassay. Up to 200 different test systems are represented across the GAP. Bioassay systems are organized according to the phylogeny of the test organisms and the end points of genetic activity. The methodology for producing and evaluating genetic activity profile was developed in collaboration with the International Agency for Research on Cancer (IARC). Data on individual chemicals were compiles by IARC and by the US Environmental Protection Agency (EPA). Data are available on 343 compounds selected from volumes 1-53 of the IARC Monographs and on 115 compounds identified as Superfund Priority Substances. Software to display the GAPs on an IBM-compatible personal computer is available from the authors. Structurally similar compounds frequently display qualitatively and quantitatively similar profiles of genetic activity. Through examination of the patterns of GAPs of pairs and groups of chemicals, it is possible to make more informed decisions regarding the selection of test batteries to be used in evaluation of chemical analogs. GAPs provided useful data for development of weight-of-evidence hazard ranking schemes. Also, some knowledge of the potential genetic activity of complex environmental mixtures may be gained from an assessment of the genetic activity profiles of component chemicals. The fundamental techniques and computer programs devised for the GAP database may be used to develop similar databases in other disciplines. 36 refs., 2 figs.

  2. 12 Years of Stellar Activity Observations in Argentina

    E-Print Network [OSTI]

    Mauas, Pablo J D; Diaz, R; Vieytes, M; Petrucci, R; Jofre, E; Abrevaya, X; Luoni, M L; Valenzuela, P

    2012-01-01T23:59:59.000Z

    We present an observational program we started in 1999, to systematically obtain mid-resolution spectra of late-type stars, to study in particular chromospheric activity. In particular, we found cyclic activity in four dM stars, including Prox-Cen. We directly derived the conversion factor that translates the known S index to flux in the Ca II cores, and extend its calibration to a wider spectral range. We investigated the relation between the activity measurements in the calcium and hydrogen lines, and found that the usual correlation observed is the product of the dependence of each flux on stellar color, and it is not always preserved when simultaneous observations of a particular star are considered. We also used our observations to model the chromospheres of stars of different spectral types and activity levels, and found that the integrated chromospheric radiative losses, normalized to the surface luminosity, show a unique trend for G and K dwarfs when plotted against the S index.

  3. The Evolving Organization of U.S. Innovation Agencies: An Overview

    E-Print Network [OSTI]

    BONVILLIAN, William B.

    2013-01-01T23:59:59.000Z

    3D printing). Other strands proposed by AMP in- cluded advanced materials, “smart” manufacturing, advanced robotics, energy-

  4. Monday 28th May Time Workshop Location

    E-Print Network [OSTI]

    Allan, Freelance, in- cluding The Guardian, MEN Lifestyle, Metro, The Telegraph and more. Room 1.23 11

  5. CORRESPONDENCE www.nature.com/naturebiotechnology DECEMBER 2002 VOLUME 20 nature biotechnology

    E-Print Network [OSTI]

    Parrott, Wayne

    more specific." He con- cludes: "As GM crops offer potential bene- fits, it would be in the industry

  6. Performance Assessment Assistance Activities in the DOE Complex - 12325

    SciTech Connect (OSTI)

    Seitz, Roger R.; Phifer, Mark A. [Savannah River National Laboratory, Savannah River Site, Bldg 773-43A, Aiken, SC 29808 (United States); Letourneau, Martin J. [U.S. Department of Energy, EM-41 19901 Germantown Road, Germantown, MD 20874-1290 (United States)

    2012-07-01T23:59:59.000Z

    The United States Department of Energy Office of Environmental Management (DOE-EM) has established a Performance Assessment Community of Practice (PA CoP) to foster the sharing of information among performance assessment (PA) and risk assessment practitioners, regulators and oversight personnel. The general intent is to contribute to continuous improvement in the consistency, technical adequacy and quality of implementation of PAs and risk assessments around the DOE Complex. The PA CoP activities have involved commercial disposal facilities and international participants to provide a global perspective. The PA CoP has also sponsored annual technical exchanges as a means to foster improved communication and to share lessons learned from on-going modelling activities. The PA CoP encourages activities to provide programmatic and technical assistance in the form of sharing experience and lessons learned with practitioners during the development of PAs and risk assessments. This assistance complements DOE-EM reviews through the Low-Level Waste Disposal Facility Federal Review Group (LFRG) that are conducted after modelling efforts are completed. Such up-front assistance is providing additional value in terms of improving consistency and sharing of information. There has been a substantial increase in the amount of assistance being provided. The assistance has been well received by practitioners and regulators that have been involved. The paper highlights assistance and sharing of information that has been conducted in the last two years to support activities underway in support of proposed disposal facilities at Paducah, Portsmouth, and the Idaho National Laboratory and tank closure at Hanford. DOE-EM established the PA CoP to help improve the consistency and quality of implementation of modelling activities around the DOE Complex. The PA CoP has sponsored annual technical exchanges as a means to foster improved communication and to share lessons learned from ongoing modelling activities. Practitioners; project managers; oversight personnel; and regulators from United States and international facilities have participated in the three technical exchanges that have been held to date. At the working level, the PA CoP has sponsored technical assistance in support of modelling activities that are currently underway. The assistance concept provides a means to share specific experience, good practices, and lessons learned on topics of interest at a given site while the modelling is being conducted. Such up-front assistance complements the sharing of information that occurs via regular LFRG meetings and independent LFRG reviews that are conducted when the modelling effort is completed. Examples from assistance activities that have been conducted at Idaho, Paducah, Portsmouth and Hanford were highlighted in this paper. There were differences in the types of assistance provided at each site. In some cases the assistance was focused on technical support for the practitioners and management responsible for the development of the PAs. At other sites, the assistance included working with the developers and regulators/stakeholders involved in the process to help with reaching consensus on critical assumptions. Such interactions have proven to be very effective to help all parties get a chance to discuss their perspectives and better understand the different points of view. In all cases, the assistance was used as a means to share broader perspectives, experiences and lessons learned with personnel engaged in a modelling activities at a given site. The combination of technical exchanges and targeted technical assistance has provided additional means to encourage the sharing of information around the DOE Complex and globally. Feedback from practitioners, oversight personnel, regulators and stakeholders that have been involved has been overwhelmingly positive. It is believed that such sharing of information and experiences is contributing to continuous improvement in the consistency, technical adequacy, and quality of modelling activities. Alt

  7. Molecular Active Sites in Heterogeneous Ir-La/C Catalyzed Carbonylatio...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Molecular Active Sites in Heterogeneous Ir-LaC Catalyzed Carbonylation of Methanol to Acetates. Molecular Active Sites in Heterogeneous Ir-LaC Catalyzed Carbonylation of Methanol...

  8. Motor activation in language processing : effects of handedness, experience, and planning 

    E-Print Network [OSTI]

    Beveridge, Madeleine Edith Louisa

    2014-07-01T23:59:59.000Z

    Embodied Cognition accounts propose that motor activation contributes to semantic representations in action language (Fischer & Zwaan, 2008). However, the nature of this activation remains largely unspecified: in particular, ...

  9. High baseline activity in inferior temporal cortex improves neural and behavioral discriminability during visual categorization

    E-Print Network [OSTI]

    Emadi, Nazli

    Spontaneous firing is a ubiquitous property of neural activity in the brain. Recent literature suggests that this baseline activity plays a key role in perception. However, it is not known how the baseline activity contributes ...

  10. Exploiting Monotonicity Constraints in Active Learning for Ordinal Classification

    E-Print Network [OSTI]

    Utrecht, Universiteit

    Utrecht University, Utrecht, The Netherlands www.cs.uu.nl #12;ISSN: 0924-3275 Department of Information and Computing Sciences Utrecht University P.O. Box 80.089 3508 TB Utrecht The Netherlands #12;Exploiting Monotonicity Constraints in Active Learning for Ordinal Classification Pieter Soons Universiteit Utrecht

  11. ACTIVE INSTABILITY CONTROL EFFECTIVENESS IN A LIQUID FUELED COMBUSTOR

    E-Print Network [OSTI]

    Lieuwen, Timothy C.

    ACTIVE INSTABILITY CONTROL EFFECTIVENESS IN A LIQUID FUELED COMBUSTOR ADAM COKER YEDIDIA NEUMEIER-fueled combustor that were performed to improve understanding of the factors limiting control performance. A set varied. They show that the combustor's nominal dynamics (i.e., without Received 23 March 2005; accepted 7

  12. Activating Mutations of NOTCH1 in Human T Cell Acute

    E-Print Network [OSTI]

    Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia Andrew P. Weng,1 Stephen C. Blacklow,1 A. Thomas Look,2 Jon C. Aster1 - Very rare cases of human T cell acute lymphoblastic leukemia (T-ALL) harbor chromosomal translocations that involve NOTCH1, a gene encoding a trans- membrane

  13. Embedded NDE with Piezoelectric Wafer Active Sensors in Aerospace Applications

    E-Print Network [OSTI]

    Giurgiutiu, Victor

    The capability of embedded piezoelectric wafer active sensors (PWAS) to perform in-situ nondestructive evaluation structural radar (EUSR). For quality assurance, PWAS are self-tested with the electromechanical impedance S s T d E D d T E = + = + (1) where E ijkls is the mechanical compliance of the material measured at zero

  14. Collaborative Construction of Task Activity: Coordinating Multiple Resources in a

    E-Print Network [OSTI]

    Sheridan, Jennifer

    Collaborative Construction of Task Activity: Coordinating Multiple Resources in a High School of the moment-to- moment construction of task, this study draws attention to complex yet taken-for- granted connections, knowing how to collaboratively construct a task. This article documents the collaborative

  15. Modeling Temporal Activity Patterns in Dynamic Social Networks

    E-Print Network [OSTI]

    Raghavan, Vasanthan; Galstyan, Aram; Tartakovsky, Alexander G

    2013-01-01T23:59:59.000Z

    The focus of this work is on developing probabilistic models for user activity in social networks by incorporating the social network influence as perceived by the user. For this, we propose a coupled Hidden Markov Model, where each user's activity evolves according to a Markov chain with a hidden state that is influenced by the collective activity of the friends of the user. We develop generalized Baum-Welch and Viterbi algorithms for model parameter learning and state estimation for the proposed framework. We then validate the proposed model using a significant corpus of user activity on Twitter. Our numerical studies show that with sufficient observations to ensure accurate model learning, the proposed framework explains the observed data better than either a renewal process-based model or a conventional uncoupled Hidden Markov Model. We also demonstrate the utility of the proposed approach in predicting the time to the next tweet. Finally, clustering in the model parameter space is shown to result in dist...

  16. The Structural Basis of Cholesterol Activity in Membranes

    SciTech Connect (OSTI)

    Olsen, Brett N.; Bielska, Agata; Lee, Tiffany; Daily, Michael D.; Covey, Douglas F.; Schlesinger, Paul H.; Baker, Nathan A.; Ory, Daniel S.

    2013-10-15T23:59:59.000Z

    Although the majority of free cellular cholesterol is present in the plasma membrane, cholesterol homeostasis is principally regulated through sterol-sensing proteins that reside in the cholesterol-poor endoplasmic reticulum (ER). In response to acute cholesterol loading or depletion, there is rapid equilibration between the ER and plasma membrane cholesterol pools, suggesting a biophysical model in which the availability of plasma membrane cholesterol for trafficking to internal membranes modulates ER membrane behavior. Previous studies have predominantly examined cholesterol availability in terms of binding to extramembrane acceptors, but have provided limited insight into the structural changes underlying cholesterol activation. In this study, we use both molecular dynamics simulations and experimental membrane systems to examine the behavior of cholesterol in membrane bilayers. We find that cholesterol depth within the bilayer provides a reasonable structural metric for cholesterol availability and that this is correlated with cholesterol-acceptor binding. Further, the distribution of cholesterol availability in our simulations is continuous rather than divided into distinct available and unavailable pools. This data provide support for a revised cholesterol activation model in which activation is driven not by saturation of membrane-cholesterol interactions but rather by bulk membrane remodeling that reduces membrane-cholesterol affinity.

  17. Structure-Activity Relationships of Antimicrobial and Lipoteichoic Acid-Sequestering Properties in Polyamine Sulfonamides

    E-Print Network [OSTI]

    Warshakoon, Hemamali J.; Burns, Mark R.; David, Sunil A.

    2009-01-01T23:59:59.000Z

    and homospermine scaffolds. We then sought to examine possible correlations between the neutralizing potency toward LTA and antimicrobial activity in Staphylococcus aureus. A linear relationship between LTA sequestration activity and antimicrobial activity...

  18. Energy Management and RD & D Activities for Energy Conservation in TEPCO

    E-Print Network [OSTI]

    Ohmori, M.; Yoshihama, K.

    1981-01-01T23:59:59.000Z

    The followings are mentioned on the experiences and results through performance of energy management and RD & D activities for energy conservation in TEPCO. - Public Relations and Energy Audit Activities. - RD & D Activities (1) Demand...

  19. First fusion proton measurements in TEXTOR plasmas using activation technique

    SciTech Connect (OSTI)

    Bonheure, G.; Wassenhove, G. Van [ERM-KMS, Trilateral Euregio Cluster, B-1000 Brussels (Belgium); Mlynar, J. [Association Euratom-IPP.CR, Institute of Plasma Physics AS CR, v.v.i., Za Slovankou 3, CZ-182 00 Praha 8 (Czech Republic); Hult, M.; Gonzalez de Orduna, R.; Lutter, G. [Institute for Reference Materials and Measurements (IRMM), Retieseweg 111, B-2440 Geel (Belgium); Vermaercke, P. [SCK-CEN, Boeretang, B-2400 Mol (Belgium); Huber, A.; Schweer, B.; Esser, G.; Biel, W. [Forschungszentrum Juelich GmbH, Institut fuer Plasmaphysik, EURATOM-Assoziation, Trilateral Euregio Cluster, D-52425 Juelich (Germany)

    2012-10-15T23:59:59.000Z

    MeV particle loss measurements from fusion plasmas, in particular alpha particles, remain difficult in large fusion devices and further R and D is needed for ITER. This paper describes the first attempt to measure 3 MeV escaping fusion protons emitted from TEXTOR tokamak plasmas using activation technique. This technique was successfully demonstrated, initially, in 2006 on the JET tokamak. An ion camera equipped with a collimator and several types of activation detectors was installed inside the TEXTOR vacuum vessel to perform these measurements. After irradiation, the detectors were analyzed using ultra low level gamma-ray spectrometry at the HADES underground laboratory. 3 MeV escaping fusion protons were detected in larger number -{approx}6 times more - compared to earlier measurements using this technique on JET. Another major progress was the reduction of the cooling time by a factor of 50, which made possible to detect radionuclides with half-life of less than 90 min.

  20. FIP Bias Evolution in a Decaying Active Region

    E-Print Network [OSTI]

    Baker, D; Démoulin, P; Yardley, S L; van Driel-Gesztelyi, L; Long, D M; Green, L M

    2015-01-01T23:59:59.000Z

    Solar coronal plasma composition is typically characterized by first ionization potential (FIP) bias. Using spectra obtained by Hinode's EUV Imaging Spectrometer (EIS) instrument, we present a series of large-scale, spatially resolved composition maps of active region (AR) 11389. The composition maps show how FIP bias evolves within the decaying AR from 2012 January 4-6. Globally, FIP bias decreases throughout the AR. We analyzed areas of significant plasma composition changes within the decaying AR and found that small-scale evolution in the photospheric magnetic field is closely linked to the FIP bias evolution observed in the corona. During the AR's decay phase, small bipoles emerging within supergranular cells reconnect with the pre-existing AR field, creating a pathway along which photospheric and coronal plasmas can mix. The mixing time scales are shorter than those of plasma enrichment processes. Eruptive activity also results in shifting the FIP bias closer to photospheric in the affected areas. Final...

  1. The Physical Activity Resource Assessment (PARA) instrument: Evaluating features, amenities and incivilities of physical activity resources in urban neighborhoods

    E-Print Network [OSTI]

    Lee, Rebecca E.; Booth, Katie M.; Reese-Smith, Jacqueline Y.; Regan, Gail; Howard, Hugh H.

    2005-09-14T23:59:59.000Z

    of a variety of PA resources. Method: The one-page Physical Activity Resource Assessment (PARA) instrument was developed to assess all publicly available PA resources in thirteen urban lower income, high ethnic minority concentration neighborhoods...

  2. EERE-Supported International Activities in Latin America (Fact Sheet)

    SciTech Connect (OSTI)

    Not Available

    2010-05-01T23:59:59.000Z

    The Office of Energy Efficiency and Renewable Energy (EERE) is involved in a variety of international initiatives, partnerships, and events that promote greater understanding and use of renewable energy (RE) and energy efficiency (EE) worldwide. In support of the Energy and Climate Partnership of the Americas (ECPA), EERE is working with several Latin American countries to advance EE and RE deployment for economic growth, energy security, poverty relief, and disaster recovery goals. This fact sheet highlights those activities.

  3. Circumnuclear Dust in Nearby Active and Inactive Galaxies. II. Bars, Nuclear Spirals, and the Fueling of Active Galactic Nuclei

    E-Print Network [OSTI]

    Paul Martini; Michael W. Regan; John S. Mulchaey; Richard W. Pogge

    2002-12-17T23:59:59.000Z

    (Abridged) We present a detailed study of the relation between circumnuclear dust morphology, host galaxy properties, and nuclear activity in nearby galaxies. We use our sample of 123 nearby galaxies with visible--near-infrared colormaps from the Hubble Space Telescope to create well-matched, "paired" samples of 28 active and 28 inactive galaxies, as well as 19 barred and 19 unbarred galaxies, that have the same host galaxy properties. Comparison of the barred and unbarred galaxies shows that grand design nuclear dust spirals are only found in galaxies with a large-scale bar. Tightly wound nuclear dust spirals, in contrast, show a strong tendency to avoid galaxies with large-scale bars. Comparison of the AGN and inactive samples shows that nuclear dust spirals, which may trace shocks and angular momentum dissipation in the ISM, occur with comparable frequency in both active and inactive galaxies. The only difference between the active and inactive galaxies is that several inactive galaxies appear to completely lack dust structure in their circumnuclear region, while none of the AGN lack this structure. The comparable frequency of nuclear spirals in active and inactive galaxies, combined with previous work that finds no significant differences in the frequency of bars or interactions between well-matched active and inactive galaxies, suggests that no universal fueling mechanism for low-luminosity AGN operates at spatial scales greater than ~100 pc radius from the galactic nuclei. The similarities instead suggest that the lifetime of nuclear activity is less than the characteristic inflow time from these spatial scales. An order-of-magnitude estimate of this inflow time is the dynamical timescale. This sets an upper limit of several million years to the lifetime of an individual episode of nuclear activity.

  4. XIAP reverses various functional activities of FRNK in endothelial cells

    SciTech Connect (OSTI)

    Ahn, Sunyoung; Kim, Hyun Jeong [Department of Molecular Biology and Institute of Nanosensor and Biotechnology, BK21 Graduate Program for RNA Biology, Dankook Univiersity, 126, Jukjeon-dong, Suji-gu, Yongin-si, Gyeonggi-do 448-701 (Korea, Republic of)] [Department of Molecular Biology and Institute of Nanosensor and Biotechnology, BK21 Graduate Program for RNA Biology, Dankook Univiersity, 126, Jukjeon-dong, Suji-gu, Yongin-si, Gyeonggi-do 448-701 (Korea, Republic of); Chi, Sung-Gil [School of Life Sciences and Biotechnology, Korea University, Seoul 136-701 (Korea, Republic of)] [School of Life Sciences and Biotechnology, Korea University, Seoul 136-701 (Korea, Republic of); Park, Heonyong, E-mail: heonyong@dankook.ac.kr [Department of Molecular Biology and Institute of Nanosensor and Biotechnology, BK21 Graduate Program for RNA Biology, Dankook Univiersity, 126, Jukjeon-dong, Suji-gu, Yongin-si, Gyeonggi-do 448-701 (Korea, Republic of)] [Department of Molecular Biology and Institute of Nanosensor and Biotechnology, BK21 Graduate Program for RNA Biology, Dankook Univiersity, 126, Jukjeon-dong, Suji-gu, Yongin-si, Gyeonggi-do 448-701 (Korea, Republic of)

    2012-03-09T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer FRNK domain is recruited into focal adhesion (FA), controlling endothelial cell adhesion. Black-Right-Pointing-Pointer XIAP binds the FRNK domain of FAK. Black-Right-Pointing-Pointer XIAP inhibits recruitment of FRNK into Fas and FRNK-promoted cell adhesion. Black-Right-Pointing-Pointer XIAP plays a key role in vascular functions of FRNK or FRNK domain-mediated vascular functions of FAK. -- Abstract: In endothelial cells, focal adhesion kinase (FAK) regulates cell proliferation, migration, adhesion, and shear-stimulated activation of MAPK. We recently found that FAK is recruited into focal adhesion (FA) sites through interactions with XIAP (X-chromosome linked inhibitor of apoptosis protein) and activated by Src kinase in response to shear stress. In this study, we examined which domain(s) of FAK is(are) important for various vascular functions such as FA recruiting, XIAP-binding and shear stress-stimulated ERK activation. Through a series of experiments, we determined that the FRNK domain is recruited into FA sites and promotes endothelial cell adhesion. Interestingly, XIAP knockdown was shown to reduce FA recruitment of FRNK and the cell adhesive effect of FRNK. In addition, we found that XIAP interacts with FRNK, suggesting cross-talk between XIAP and FRNK. We also demonstrated that FRNK inhibits endothelial cell migration and shear-stimulated ERK activation. These inhibitory effects of FRNK were reversed by XIAP knockdown. Taken together, we can conclude that XIAP plays a key role in vascular functions of FRNK or FRNK domain-mediated vascular functions of FAK.

  5. PERFORMANCE ASSESSMENT ASSISTANCE ACTIVITIES IN THE DOE COMPLEX

    SciTech Connect (OSTI)

    Seitz, R.

    2012-01-23T23:59:59.000Z

    The United States Department of Energy Office of Environmental Management (DOE-EM) has established a Performance Assessment Community of Practice (PA CoP) to foster the sharing of information among performance assessment (PA) and risk assessment practitioners, regulators and oversight personnel. The general intent is to contribute to continuous improvement in the consistency, technical adequacy and quality of implementation of PAs and risk assessments around the DOE Complex. The PA CoP activities have involved commercial disposal facilities and international participants to provide a global perspective. The PA CoP has also sponsored annual technical exchanges as a means to foster improved communication and to share lessons learned from on-going modelling activities. The PA CoP encourages activities to provide programmatic and technical assistance in the form of sharing experience and lessons learned with practitioners during the development of PAs and risk assessments. This assistance complements DOE-EM reviews through the Low-Level Waste Disposal Facility Federal Review Group (LFRG) that are conducted after modelling efforts are completed. Such up-front assistance is providing additional value in terms of improving consistency and sharing of information. There has been a substantial increase in the amount of assistance being provided. The assistance has been well received by practitioners and regulators that have been involved. The paper highlights assistance and sharing of information that has been conducted in the last two years to support activities underway in support of proposed disposal facilities at Paducah, Portsmouth, and the Idaho National Laboratory and tank closure at Hanford.

  6. Effect of Sawtooth Activity on Tritium and Beam Deuterium Evolution in Trace Tritium Experiments on JET

    E-Print Network [OSTI]

    Effect of Sawtooth Activity on Tritium and Beam Deuterium Evolution in Trace Tritium Experiments on JET

  7. Abstract --The need to determine adequate regulations in the transmission activity in deregulated environments does not

    E-Print Network [OSTI]

    Dixon, Juan

    Abstract -- The need to determine adequate regulations in the transmission activity in deregulated. II SYSTEM EXPANSION IN CHILEAN DEREGULATION In Chile there is full freedom for investment

  8. EVIDENCE OF IMPULSIVE HEATING IN ACTIVE REGION CORE LOOPS

    SciTech Connect (OSTI)

    Tripathi, Durgesh; Mason, Helen E. [Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA (United Kingdom); Klimchuk, James A., E-mail: d.tripathi@damtp.cam.ac.u [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States)

    2010-11-01T23:59:59.000Z

    Using a full spectral scan of an active region from the Extreme-Ultraviolet Imaging Spectrometer (EIS) we have obtained emission measure EM(T) distributions in two different moss regions within the same active region. We have compared these with theoretical transition region EMs derived for three limiting cases, namely, static equilibrium, strong condensation, and strong evaporation from Klimchuk et al. The EM distributions in both the moss regions are strikingly similar and show a monotonically increasing trend from log T[K] = 5.15-6.3. Using photospheric abundances, we obtain a consistent EM distribution for all ions. Comparing the observed and theoretical EM distributions, we find that the observed EM distribution is best explained by the strong condensation case (EM{sub con}), suggesting that a downward enthalpy flux plays an important and possibly dominant role in powering the transition region moss emission. The downflows could be due to unresolved coronal plasma that is cooling and draining after having been impulsively heated. This supports the idea that the hot loops (with temperatures of 3-5 MK) seen in the core of active regions are heated by nanoflares.

  9. Occupational employment in nuclear-related activities, 1981

    SciTech Connect (OSTI)

    Baker, J.G.; Olsen, K.

    1982-04-01T23:59:59.000Z

    1981 employment in nuclear-related activities is described, and compared to previous years. Employment characteristics examined include detailed occupations of scientists, engineers, and technicians; worker involvement in research and development activities; employment by industrial segment (e.g., reactor operation and maintenance, weapons production, and commercial laboratory services); employment by establishment type (government-owned, contractor-operated (GOCO), private, and nonprofit); regional employment; and employment by establishment size. Total 1981 nuclear-related employment is estimated to be 249,500 - a growth of 22,600 workers over the 1977 total. GOCO workers make up 36.9% of this total. Among all the nuclear-related workers, scientists comprise 5.1%, engineers, 15.3%; and technicians, 17.5%; the remaining 62.1% is composed of managers, skilled craft and clerical workers, and other support services. Research and development involvement has declined from the 1977 survey results, with 60.4% of scientists and 27.0% of engineers currently involved in R and D. The largest single industrial segment activity is weapons development (16.9% of total employment), followed closely by reactor operation and maintenance employment (16.7%). There has been considerable change in the distribution of employment by industrial segment from 1977 to 1981; the reactor and reactor component design and manufacturing segment fell by over 9700 workers while reactor operation and maintenance employment grew by over 24,000 workers.

  10. Sociological adaptation among bacterial populations in an activated sludge ecosystem

    E-Print Network [OSTI]

    Forrest, Robert George

    1970-01-01T23:59:59.000Z

    Bacillus Corynebacterium, and Micrococcus being much less abundant. Unz and Dondero (70) isolated two-hundred and three strains from fifty-one trickling filters and activated sludge zoogloeas, with one-hundred and forty-seven of the strains forming... in the aeration basin or secondary sedimentation biomass; instead, members of the Flavobacterium C'~oh~as group, the genus Achromobacter, and a Pseudomonas-l&e group were most numerous. METHODS AND MATERIALS Batch fermentation s stem. The bench scale batch...

  11. Revisiting the question: Does high-latitude solar activity lead low-latitude solar activity in time phase?

    SciTech Connect (OSTI)

    Kong, D. F.; Qu, Z. N. [Yunnan Observatories, Chinese Academy of Sciences, Kunming 650011 (China); Guo, Q. L., E-mail: kdf@ynao.ac.cn [College of Mathematics Physics and Information Engineering, Jiaxing University, Jiaxing 314001 (China)

    2014-05-01T23:59:59.000Z

    Cross-correlation analysis and wavelet transform methods are used to investigate whether high-latitude solar activity leads low-latitude solar activity in time phase or not, using the data of the Carte Synoptique solar filaments archive from 1919 March to 1989 December. From the cross-correlation analysis, high-latitude solar filaments have a time lead of 12 Carrington solar rotations with respect to low-latitude ones. Both the cross-wavelet transform and wavelet coherence indicate that high-latitude solar filaments lead low-latitude ones in time phase. Furthermore, low-latitude solar activity is better correlated with high-latitude solar activity of the previous cycle than with that of the following cycle, which is statistically significant. Thus, the present study confirms that high-latitude solar activity in the polar regions is indeed better correlated with the low-latitude solar activity of the following cycle than with that of the previous cycle, namely, leading in time phase.

  12. Nematic ordering of topological defects in active liquid crystals

    E-Print Network [OSTI]

    Anand U. Oza; Jörn Dunkel

    2015-07-15T23:59:59.000Z

    Identifying the ordering principles of intracellular matter is key to understanding the physics of microbiological systems. Recent experiments show that ATP-driven microtubule-kinesin bundles can form non-equilibrium networks of liquid-crystalline order when trapped in an oil-water interface near a solid boundary. At high densities, the bundles realize a 2D active nematic phase characterized by spontaneous creation and annihilation of topological defects, reminiscent of particle-pair production processes in quantum systems. This remarkable discovery sparked considerable theoretical interest, yet a satisfactory mathematical description has remained elusive, primarily for the following two reasons. First, prevailing multi-component theories feature a large number of unknown parameters that make quantitative comparison with experiment infeasible. Second, the currently favored hydrodynamic models assume divergence-free 2D interfacial flow, thereby promoting turbulent pattern formation through upward cascades. Such cascades are unlikely to occur in experiments, where interface and bulk fluid can continuously exchange matter. Here, we propose a compact alternative continuum theory for dense active liquid crystals by merging ideas from the Landau-de Gennes and Swift-Hohenberg theories. The resulting fourth-order model agrees quantitatively with experimental data, correctly predicts a regime of long-range nematic alignment of defects, and manifests an analogy with a generalized Gross-Pitaevskii quantum theory. Generally, our results suggest that universal ordering principles may govern a wide range of active materials.

  13. Biodegradation of triclosan and formation of methyl-triclosan in activated sludge under aerobic conditions

    E-Print Network [OSTI]

    Kolaei, Alireza Rezania

    Biodegradation of triclosan and formation of methyl-triclosan in activated sludge under aerobic in activated sludge from a standard activated sludge WWTP equipped with enhanced biological phosphorus removal) and anaerobic conditions rather low removal rates were determined. In a laboratory-scale activated sludge

  14. Activities of HPS standards committee in environmental remediation

    SciTech Connect (OSTI)

    Stencel, J.R. [Princeton Univ., NJ (United States). Plasma Physics Lab.; Chen, S.Y. [Argonne National Lab., IL (United States)

    1994-12-31T23:59:59.000Z

    The Health Physics Society (HPS) develops American National Standards in the area of radiation protection using methods approved by the American National Standards Institute (ANSI). Two of its sections, Environmental Health Physics and Contamination Limits, have ongoing standards development which are important to some environmental remediation efforts. This paper describes the role of the HPS standards process and indicates particular standards under development which will be of interest to the reader. In addition, the authors solicit readers to participate in the voluntary standards process by either joining active working groups (WG) or suggesting appropriate and relevant topics which should be placed into the standards process.

  15. Generalized energy equipartition in harmonic oscillators driven by active baths

    E-Print Network [OSTI]

    Claudio Maggi; Matteo Paoluzzi; Nicola Pellicciotta; Alessia Lepore; Luca Angelani; Roberto Di Leonardo

    2014-11-06T23:59:59.000Z

    We study experimentally and numerically the dynamics of colloidal beads confined by a harmonic potential in a bath of swimming E. coli bacteria. The resulting dynamics is well approximated by a Langevin equation for an overdamped oscillator driven by the combination of a white thermal noise and an exponentially correlated active noise. This scenario leads to a simple generalization of the equipartition theorem resulting in the coexistence of two different effective temperatures that govern dynamics along the flat and the curved directions in the potential landscape.

  16. Activation of building air in a Tokamak Engineering Test Facility

    SciTech Connect (OSTI)

    Leonard, B.R. Jr.; Perry, R.T.

    1980-09-01T23:59:59.000Z

    The production of radionuclides by neutron reactions in the building air of a conceptual Tokamak Engineering Test Facility has been calculated. The short-lived radionuclides /sup 13/N, /sup 16/N and /sup 41/Ar are all found to greatly exceed their maximum permissable concentration values. Longer-lived radionuclides /sup 3/H, /sup 14/C and /sup 39/Ar are also found to be produced in significant concentrations. The present results are compared with values calculated for three other fusion devices; TFTR, INS, and FMIT. These comparisons show that the ETF can be a prolific producer of activated air.

  17. On the Mechanism of Activated Transport in Glassy Liquids

    E-Print Network [OSTI]

    Vassiliy Lubchenko; Pyotr Rabochiy

    2014-12-03T23:59:59.000Z

    We explore several potential issues that have been raised over the years regarding the "entropic droplet" scenario of activated transport in liquids, due to Wolynes and coworkers, with the aim of clarifying the status of various approximations of the random first order transition theory (RFOT) of the structural glass transition. In doing so, we estimate the mismatch penalty between alternative aperiodic structures, above the glass transition; the penalty is equal to the typical magnitude of free energy fluctuations in the liquid. The resulting expressions for the activation barrier and the cooperativity length contain exclusively bulk, static properties; in their simplest form they contains only the bulk modulus and the configurational entropy per unit volume. The expressions are universal in that they do not depend explicitly on the molecular detail. The predicted values for the barrier and cooperativity length and, in particular, the temperature dependence of the barrier are in satisfactory agreement with observation. We thus confirm that the entropic droplet picture is indeed not only internally-consistent but is also fully constructive, consistent with the apparent success of its many quantitative predictions. A simple view of a glassy liquid as a locally metastable, degenerate pattern of frozen-in stress emerges in the present description. Finally, we derive testable relationships between the bulk modulus and several characteristics of glassy liquids and peculiarities in low-temperature glasses.

  18. Increased activity expected in Permian basin, Gulf of Mexico

    SciTech Connect (OSTI)

    Hagar, R.

    1988-03-14T23:59:59.000Z

    Exploration and development activities in two of the most important petroleum provinces in the U.S. are mixed, but the outlook is bright. There has been a steady increase in drilling in oil plays of the deepwater Gulf of Mexico and in the Permian basin of West Texas and New Mexico. But natural gas drilling has not seen much of an increase, although activity involving Miocne sands in the shallow water portion of the gulf is starting to pick up. Deep gas drilling, stalled by the 1986 spot price collapse, has not yet shown signs of new life, even though production is scheduled to begin this year from the Jurassic Norphlet deep gas play off Alabama. There should be continued increases this year in deepwater and Permian basin drilling if oil prices remain in the $18-20/bbl range. And gas drilling is expected to pick up considerably if spot prices strengthen. An important factor in the drilling outlook is an expectation that major interstate transmission companies this year will resume buying long term gas supplies for resale. Long term contracts reduce producer uncertainty in project economics.

  19. Vaticaffinol, a resveratrol tetramer, exerts more preferable immunosuppressive activity than its precursor in vitro and in vivo through multiple aspects against activated T lymphocytes

    SciTech Connect (OSTI)

    Feng, Li-Li; Wu, Xue-Feng; Liu, Hai-Liang; Guo, Wen-Jie; Luo, Qiong; Tao, Fei-Fei; Ge, Hui-Ming; Shen, Yan; Tan, Ren-Xiang; Xu, Qiang, E-mail: molpharm@163.com; Sun, Yang, E-mail: yangsun@nju.edu.cn

    2013-03-01T23:59:59.000Z

    In the present study, we aimed to investigate the immunosuppressive activity of vaticaffinol, a resveratrol tetramer isolated from Vatica mangachapoi, on T lymphocytes both in vitro and in vivo, and further explored its potential molecular mechanism. Resveratrol had a wide spectrum of healthy beneficial effects with multiple targets. Interestingly, its tetramer, vaticaffinol, exerted more intensive immunosuppressive activity than resveratrol. Vaticaffinol significantly inhibited T cells proliferation activated by concanavalin A (Con A) or anti-CD3 plus anti-CD28 in a dose- and time-dependent manner. It also induced Con A-activated T cells undergoing apoptosis through mitochondrial pathway. Moreover, this compound prevented cells from entering S phase and G2/M phase during T cells activation. In addition, vaticaffinol inhibited ERK and AKT signaling pathways in Con A-activated T cells. Furthermore, vaticaffinol significantly ameliorated ear swelling in a mouse model of picryl chloride-induced ear contact dermatitis in vivo. In most of the aforementioned experiments, however, resveratrol had only slight effects on the inhibition of T lymphocytes compared with vaticaffinol. Taken together, our findings suggest that vaticaffinol exerts more preferable immunosuppressive activity than its precursor resveratrol both in vitro and in vivo by affecting multiple targets against activated T cells. - Graphical abstract: Vaticaffinol, a resveratrol tetramer isolated from Vatica mangachapoi, exerts more intensive immunosuppressive activity than its precursor resveratrol does in vitro and in vivo. Its mechanism may involve multiple effects against activated T cells: regulation of signalings involved in cell proliferation, G0/G1 arrest of T cells, as well as an apoptosis induction in activated effector T cells. Highlights: ? Vaticaffinol, a resveratrol tetramer, exerts more potent activity than its precursor. ? It inhibited T cells proliferation and prevented them from entering cell cycles. ? It led to apoptosis of activated T cells through mitochondrial pathway. ? It down-regulated ERK and AKT signaling pathways in Con A-activated T cells. ? It significantly ameliorated picryl chloride-induced ear swelling.

  20. Update on petroleum exploration activities in the Philippines

    SciTech Connect (OSTI)

    Salcedo, B.H.C.; Bausa, G.J.G.; Ocampo. I.U. [and others

    1996-12-31T23:59:59.000Z

    The first significant event in Philippine Petroleum exploration dates back to 1896 with the drilling of Toledo-1 in Cebu by Smith & Bell. From the 1950`s to the 1970`s, widespread exploration activities were carried out but it was only eighty years after the first oil drilling in 1896 that oil was finally discovered in commercial quantity in Northwest Palawan. This could be attributed to the fact that serious exploration for petroleum was made with the enactment of Presidential Decree No. 87, better known as the {open_quotes}Oil Exploration and Development Act of 1972{close_quotes}, which takes into effect the current Service Contract System. Amendments to P.D. No. 87 is underway to further improve its incentive package and make it more attractive to explorationists. Petroleum exploration in the Philippines continues to be an energetic industry even if the players are not always rewarded with finds. Frontier areas have become attractive for exploration in view of the continuing research studies resulting to increased database thereat. While Northwest Palawan continues to be the hub of action, frontier areas as well as the more risky deepwater acreages still generate interests, if one wishes to be an active player in a growing energy-hungry economy.

  1. Update on petroleum exploration activities in the Philippines

    SciTech Connect (OSTI)

    Salcedo, B.H.C.; Bausa, G.J.G.; Ocampo. I.U. (and others)

    1996-01-01T23:59:59.000Z

    The first significant event in Philippine Petroleum exploration dates back to 1896 with the drilling of Toledo-1 in Cebu by Smith Bell. From the 1950's to the 1970's, widespread exploration activities were carried out but it was only eighty years after the first oil drilling in 1896 that oil was finally discovered in commercial quantity in Northwest Palawan. This could be attributed to the fact that serious exploration for petroleum was made with the enactment of Presidential Decree No. 87, better known as the [open quotes]Oil Exploration and Development Act of 1972[close quotes], which takes into effect the current Service Contract System. Amendments to P.D. No. 87 is underway to further improve its incentive package and make it more attractive to explorationists. Petroleum exploration in the Philippines continues to be an energetic industry even if the players are not always rewarded with finds. Frontier areas have become attractive for exploration in view of the continuing research studies resulting to increased database thereat. While Northwest Palawan continues to be the hub of action, frontier areas as well as the more risky deepwater acreages still generate interests, if one wishes to be an active player in a growing energy-hungry economy.

  2. Overview of Recent Japanese Activities in Fusion Technology

    SciTech Connect (OSTI)

    Seki, Masahiro [Japan Atomic Energy Research Institute (Japan); Yamamoto, I. [Nagoya University (Japan); Sagara, A. [NIFS (Japan)

    2005-04-15T23:59:59.000Z

    After the ITER/EDA study, Japanese activities in fusion technology have been mainly devoted to DEMO reactors. The paper intends to overview these activities.With respect to the test blanket modules, solid breeder blankets with ferritic steel structure cooled by helium and water are being developed by JAERI in cooperation with universities and NIFS. Advanced blankets are being developed by universities and NIFS. In the area of tritium processing technology, R and D has been focused on the blanket tritium recovery technology. In terms of the superconducting magnet, JAERI has performed basic research for the Fusion Power Demonstration Plant, aiming at realization of toroidal filed higher than 13 T using innovative superconductors, such as Nb{sub 3}Al and High Temperature Superconductors (HTS). In the R and D of negative ion based NBI technologies, a H{sup -} beam of 110 mA has been stably accelerated up to 0.9 MeV, which corresponds to the current density of 80 A/m{sup 2}. A beam power of 13.1 MW at 180 keV has been injected from three injectors in the LHD N-NBI. With respect to the radio-frequency heating technology, development of 170GHz ITER gyrotron has been progressed to achieve a 500kW for 100 sec operation in JAERI. Long pulse injection for 766 sec with 72 kW at 84 GHz was achieved in a LHD ECH experiment.

  3. Enhanced diffusion in shock activated Be-Al interfaces

    SciTech Connect (OSTI)

    Staudhammer, K.P.

    1997-05-01T23:59:59.000Z

    Enhanced diffusion of aluminum in shock activated beryllium has been observed. Cylindrical samples of aluminum coated beryllium rods were axisymetrically loaded up to 40 GPa and a total residual strain of up to 6.7%. The defect microstructure produced by both the shock wave and strain enabled the transport of aluminum in beryllium to exceed its equilibrium solid state saturation. This {open_quotes}super saturated{close_quotes} aluminum, upon heating exsolves out at relatively low temperatures and forms very strong interfaces with pressure mated components.

  4. Atmos. Chem. Phys., 9, 88838888, 2009 www.atmos-chem-phys.net/9/8883/2009/

    E-Print Network [OSTI]

    likely source regions with the assumption that there are regional differences in pollu- tion aerosol; its most significant pollution source is combustion of heavy residual oil (Zoller et al., 1973) which of anthropogenic activities in- cluding iron, steel, and ferro-alloy manufacturing; coal com- bustion; oil

  5. Changes in vigorous physical activity and incident diabetes inmale runners

    SciTech Connect (OSTI)

    Williams, Paul T.

    2007-04-30T23:59:59.000Z

    We examined the dose-response relationship between changes in reported vigorous exercise (running distance, {Delta}km/wk) and self-reported physician diagnosed diabetes in 25,988 men followed prospectively for (mean {+-} SD) 7.8 {+-} 1.8 years. Logistic regression analyses showed that the log odds for diabetes declined significantly in relation to men's {Delta}km/wk (coefficient {+-} SE: -0.012 {+-} 0.004, P < 0.01), which remained significant when adjusted for BMI (-0.018 {+-} 0.003, P < 0.0001). The decline in the log odds for diabetes was related to the distance run at the end of follow-up when adjusted for baseline distance, with (-0.024 {+-} 0.005, P < 0.0001) or without (-0.027 {+-} 0.005, P < 0.0001) adjustment for BMI. Baseline distance was unrelated to diabetes incidence when adjusted for the distance at the end of follow-up. Compared to men who ran <8 km/wk at the end of follow-up, incidence rates in those who ran {ge} 8 km/wk were 95% lower between 35-44 yrs old (P < 0.0001), 92% lower between 45-54 yrs old (P < 0.0001), 87% lower between 55 and 64 years old (P < 0.0001), and 46% lower between 65-75 yrs old (P = 0.30). For the subset of 6,208 men who maintained the same running distance during follow-up ({+-}5 km/wk), the log odds for diabetes declined with weekly distance run (-0.024 {+-} 0.010, P = 0.02) but not when adjusted for BMI (-0.005 {+-} 0.010, P = 0.65). Conclusion: Vigorous exercise significantly reduces diabetes incidence, due in part to the prevention of age-related weight gain and in part to other exercise effects. Physical activity decreases the risk of type 2 diabetes [1-10]. Moderate and vigorous exercise are purported to produce comparable reductions in diabetes risk if the energy expenditure is the same [3,10]. The optimal physical activity dose remains unclear, however, with some [4-7] but not all studies [1,8,9] showing continued reduction in diabetes for high versus intermediate energy expenditures. The National Runners Health Study [11-19] is unique among population cohorts in its focus on the health impact of higher doses of vigorously intense physical activity (i.e., {ge} 6-fold metabolic rate). The study was specifically designed to evaluate the dose-response relationship between vigorous physical activity and health for intensities and durations that exceed current physical activity recommendations [20-22]. One specific hypothesis is whether changes in vigorous physical activity affect the risk for becoming diabetic. Although women were surveyed and followed-up, only 23 developed diabetes so there is limited statistical power to establish their significance. Our analyses of diabetes and vigorous exercise are therefore restricted to men. This paper relates running distance at baseline and at the end of follow-up to self-reported, physician diagnosed diabetes in vigorously active men who were generally lean and ostensibly at low diabetic risk The benefits of greater doses of more vigorous exercise are relevant to the 27% of U.S. women and 34% of U.S. men meet or exceed the more general exercise recommendations for health benefits [23]. Specific issues to be addressed are: (1) whether maintenance of the same level of vigorous exercise over time reduces the risk of incident diabetes in relation to the exercise dose; (2) whether men who decrease their activity increase their risk for becoming diabetic; and (3) whether end of follow-up running distances are more predictive of diabetes than baseline distances, suggesting a causal, acute effect. Elsewhere we have shown that greater body weight is related to a lack of vigorous exercise [12-14] and increases the risk for diabetes even among generally lean vigorously active men [11]. In runners, leanness may be due to the exercise or due to initially lean men choosing to run further [17]. Therefore we also test whether body weight mediates the effects of vigorous exercise on diabetes, and whether this may be due to self-selection.

  6. PHYSICAL PROPERTIES OF COOLING PLASMA IN QUIESCENT ACTIVE REGION LOOPS

    SciTech Connect (OSTI)

    Landi, E. [Artep, Inc. at Naval Research Laboratory, 4555 Overlook Ave. S.W., 20375-5320, Washington DC (United States); Miralles, M. P. [Harvard-Smithsonian Center for Astrophysics, 60 Garden St., MS-50, Cambridge, MA 02138 (United States); Curdt, W. [Max Planck Institut fuer Sonnensystemforschung, Max Planck Strasse 2, Katlenburg-Lindau 37191 (Germany); Hara, H. [National Astronomical Observatory of Japan, Osawa, Mitaka, Tokyo 181-8588 (Japan)

    2009-04-10T23:59:59.000Z

    In the present work, we use SOHO/SUMER, SOHO/UVCS, SOHO/EIT, SOHO/LASCO, STEREO/EUVI, and Hinode/EIS coordinated observations of an active region (AR 10989) at the west limb taken on 2008 April 8 to study the cooling of coronal loops. The cooling plasma is identified using the intensities of SUMER spectral lines emitted at temperatures in the 4.15 {<=} log T {<=} 5.45 range. EIS and SUMER spectral observations are used to measure the physical properties of the loops. We found that before cooling took place these loops were filled with coronal hole-like plasma, with temperatures in the 5.6 {<=} log T {<=} 5.9 range. SUMER spectra also allowed us to determine the plasma temperature, density, emission measure, element abundances, and dynamic status during the cooling process. The ability of EUVI to observe the emitting region from a different direction allowed us to measure the volume of the emitting region and estimate its emission measure. Comparison with values measured from line intensities provided us with an estimate of the filling factor. UVCS observations of the coronal emission above the active region showed no streamer structure associated with AR 10989 at position angles between 242{sup 0}and 253.{sup 0} EIT, LASCO, and EUVI-A narrowband images and UVCS spectral observations were used to discriminate between different scenarios and monitor the behavior of the active region in time. The present study provides the first detailed measurements of the physical properties of cooling loops, a very important benchmark for theoretical models of loop cooling and condensation.

  7. Development/Plasticity/Repair Phosphatidylinositol 3-Kinase Activates ERK in Primary

    E-Print Network [OSTI]

    Clapham, David E.

    Development/Plasticity/Repair Phosphatidylinositol 3-Kinase Activates ERK in Primary Sensory activation to inflammatory pain. We further investigated the correlationbetweenthePI3KandtheERK294002 and wortmannin, indicative of the activation of PI3K by both agents. ERK activation by capsaicin

  8. Stochastic dynamics of active swimmers in linear flows

    E-Print Network [OSTI]

    Mario Sandoval; Navaneeth K. M.; Ganesh Subramanian; Eric Lauga

    2014-06-17T23:59:59.000Z

    Most classical work on the hydrodynamics of low-Reynolds-number swimming addresses deterministic locomotion in quiescent environments. Thermal fluctuations in fluids are known to lead to a Brownian loss of the swimming direction. As most cells or synthetic swimmers are immersed in external flows, we consider theoretically in this paper the stochastic dynamics of a model active particle (a self-propelled sphere) in a steady general linear flow. The stochasticity arises both from translational diffusion in physical space, and from a combination of rotary diffusion and run-and-tumble dynamics in orientation space. We begin by deriving a general formulation for all components of the long-time mean square displacement tensor for a swimmer with a time-dependent swimming velocity and whose orientation decorrelates due to rotary diffusion alone. This general framework is applied to obtain the convectively enhanced mean-squared displacements of a steadily-swimming particle in three canonical linear flows (extension, simple shear, and solid-body rotation). We then show how to extend our results to the case where the swimmer orientation also decorrelates on account of run-and-tumble dynamics. Self-propulsion in general leads to the same long-time temporal scalings as for passive particles in linear flows but with increased coefficients. In the particular case of solid-body rotation, the effective long-time diffusion is the same as that in a quiescent fluid, and we clarify the lack of flow-dependence by briefly examining the dynamics in elliptic linear flows. By comparing the new active terms with those obtained for passive particles we see that swimming can lead to an enhancement of the mean-square displacements by orders of magnitude, and could be relevant for biological organisms or synthetic swimming devices in fluctuating environmental or biological flows.

  9. Dynamical Processes in the Central Kpc and Active Galactic Nuclei

    E-Print Network [OSTI]

    Isaac Shlosman

    2003-06-18T23:59:59.000Z

    We discuss different aspects of nested bar dynamics and its effect on the gas flow and fueling of Active Galactic Nuclei. Specifically we focus on the dynamical decoupling between the primary and secondary bars and the gas flow across the bar-bar interface. We analyze the nuclear gaseous bar formation when gas gravity can be neglected or when it dominates. Finally, we discuss the possible effect of flat core, triaxial, dark halos on the formation of galactic bulges and supermassive black holes (SBHs) and argue in favor of SBH-bulge-halo correlation.

  10. Overview of Japanese Activities in Thermoelectrics | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn'tOrigin of Contamination in ManyDepartmentOutreach toTransmissionProgram |andJapanese Activities

  11. Overview of tritium activity in Japan | Department of Energy

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011 Strategic2 OPAM615_CostNSAR - T en Y earEnergy Ttritium activity in Japan Overview of

  12. 7000 years of paleostorm activity in the NW Mediterranean Sea in response to Holocene climate events

    E-Print Network [OSTI]

    Demouchy, Sylvie

    7000 years of paleostorm activity in the NW Mediterranean Sea in response to Holocene climate for high storm activity in the NW Mediterranean Sea is in agreement with the changes in coast- al under future climate change conditions. Cyclones cause most of the heavy precipitation events in the en

  13. Internal dynamics and activated processes in Soft-Glassy materials

    E-Print Network [OSTI]

    R. Benzi; M. Sbragaglia; A. Scagliarini; P. Perlekar; M. Bernaschi; S. Succi; F. Toschi

    2014-10-24T23:59:59.000Z

    Plastic rearrangements play a crucial role in the characterization of soft-glassy materials, such as emulsions and foams. Based on numerical simulations of soft-glassy systems, we study the dynamics of plastic rearrangements at the hydrodynamic scales where thermal fluctuations can be neglected. Plastic rearrangements require an energy input, which can be either provided by external sources, or made available through time evolution in the coarsening dynamics, in which the total interfacial area decreases as a consequence of the slow evolution of the dispersed phase from smaller to large droplets/bubbles. We first demonstrate that our hydrodynamic model can quantitatively reproduce such coarsening dynamics. Then, considering periodically oscillating strains, we characterize the number of plastic rearrangements as a function of the external energy-supply, and show that they can be regarded as activated processes induced by a suitable "noise" effect. Here we use the word noise in a broad sense, referring to the internal non-equilibrium dynamics triggered by spatial random heterogeneities and coarsening. Finally, by exploring the interplay between the internal characteristic time-scale of the coarsening dynamics and the external time-scale associated with the imposed oscillating strain, we show that the system exhibits the phenomenon of stochastic resonance, thereby providing further credit to the mechanical activation scenario.

  14. Activation-analysis determination of the gadolinium content in zirconium

    SciTech Connect (OSTI)

    Rudenko, V.S.; Medvedev, A.B.

    1987-05-01T23:59:59.000Z

    The authors consider a method of determining the gadolinium content in zirconium from the attenuation of the thermalized neutron flux of the isotopic source in the sample with the aid of an activation detector for monitoring the neutron flux. In the proposed method, use is made of the difference in the cross sections of gadolinium and zirconium nuclei for neutron absorption. In the energy range up to 0.1 MeV the total neutron absorption cross section of gadolinium is almost four orders of magnitude greater than that of zirconium. This situation makes it possible to devise a nondestructive rapid method of determining the gadolinium content from the attenuation of the thermalized neutron flux in the sample under study.

  15. Nonequilibrium Glass Transition in Mixtures of Active-Passive Particles

    E-Print Network [OSTI]

    Ding, Huai; Jiang, Huijun; Hou, Zhonghuai

    2015-01-01T23:59:59.000Z

    We develop a mode coupling theory(MCT) to study the nonequilibrium glass transition behavior of a mono-disperse mixture of active-passive hard-sphere particles. The MCT equations clearly demonstrate that the glass transition is shifted to higher values of total volume fraction when doping a passive system with active particles. Interestingly, we find that the glass transition point may show a non-monotonic dependence on the effective diffusivity of the active component, indicating a nontrivial type of activity induced reentrance behavior. Analysis based on the nonergodic parameters suggest that the glassy state at small activity is due to the caging effect, while that at high activity could result from activity induced dynamic clustering.

  16. Identification of active agents for tetrachloroethylene degradation in Portland cement slurry containing ferrous iron

    E-Print Network [OSTI]

    Ko, Sae Bom

    2006-08-16T23:59:59.000Z

    -EDS) were used to identify minerals in chemical mixtures that have high activities. Results indicate that active agents for PCE degradation in Portland cement slurries and in cement extracts might be one of several AFm phases. However, systems without cement...

  17. Engineering intracellular active transport systems as in vivo biomolecular tools.

    SciTech Connect (OSTI)

    Bachand, George David; Carroll-Portillo, Amanda

    2006-11-01T23:59:59.000Z

    Active transport systems provide essential functions in terms of cell physiology and metastasis. These systems, however, are also co-opted by invading viruses, enabling directed transport of the virus to and from the cell's nucleus (i.e., the site of virus replication). Based on this concept, fundamentally new approaches for interrogating and manipulating the inner workings of living cells may be achievable by co-opting Nature's active transport systems as an in vivo biomolecular tool. The overall goal of this project was to investigate the ability to engineer kinesin-based transport systems for in vivo applications, specifically the collection of effector proteins (e.g., transcriptional regulators) within single cells. In the first part of this project, a chimeric fusion protein consisting of kinesin and a single chain variable fragment (scFv) of an antibody was successfully produced through a recombinant expression system. The kinesin-scFv retained both catalytic and antigenic functionality, enabling selective capture and transport of target antigens. The incorporation of a rabbit IgG-specific scFv into the kinesin established a generalized system for functionalizing kinesin with a wide range of target-selective antibodies raised in rabbits. The second objective was to develop methods of isolating the intact microtubule network from live cells as a platform for evaluating kinesin-based transport within the cytoskeletal architecture of a cell. Successful isolation of intact microtubule networks from two distinct cell types was demonstrated using glutaraldehyde and methanol fixation methods. This work provides a platform for inferring the ability of kinesin-scFv to function in vivo, and may also serve as a three-dimensional scaffold for evaluating and exploiting kinesin-based transport for nanotechnological applications. Overall, the technology developed in this project represents a first-step in engineering active transport system for in vivo applications. Further development could potentially enable selective capture of intracellular antigens, targeted delivery of therapeutic agents, or disruption of the transport systems and consequently the infection and pathogenesis cycle of biothreat agents.

  18. Measuring Shared Information and Coordinated Activity in Neuronal Networks

    E-Print Network [OSTI]

    Kristina Lisa Klinkner; Cosma Rohilla Shalizi; Marcelo F. Camperi

    2005-07-29T23:59:59.000Z

    Most nervous systems encode information about stimuli in the responding activity of large neuronal networks. This activity often manifests itself as dynamically coordinated sequences of action potentials. Since multiple electrode recordings are now a standard tool in neuroscience research, it is important to have a measure of such network-wide behavioral coordination and information sharing, applicable to multiple neural spike train data. We propose a new statistic, informational coherence, which measures how much better one unit can be predicted by knowing the dynamical state of another. We argue informational coherence is a measure of association and shared information which is superior to traditional pairwise measures of synchronization and correlation. To find the dynamical states, we use a recently-introduced algorithm which reconstructs effective state spaces from stochastic time series. We then extend the pairwise measure to a multivariate analysis of the network by estimating the network multi-information. We illustrate our method by testing it on a detailed model of the transition from gamma to beta rhythms.

  19. Two-phase flow in a chemically active porous medium

    E-Print Network [OSTI]

    Alexandre Darmon; Michael Benzaquen; Thomas Salez; Olivier Dauchot

    2014-11-20T23:59:59.000Z

    We study the problem of the transformation of a given reactant species into an immiscible product species, as they flow through a chemically active porous medium. We derive the equation governing the evolution of the volume fraction of the species -- in a one-dimensional macroscopic description --, identify the relevant dimensionless numbers, and provide simple models for capillary pressure and relative permeabilities, which are quantities of crucial importance when tackling multiphase flows in porous media. We set the domain of validity of our models and discuss the importance of viscous coupling terms in the extended Darcy's law. We investigate numerically the steady regime and demonstrate that the spatial transformation rate of the species along the reactor is non-monotonous, as testified by the existence of an inflection point in the volume fraction profiles. We obtain the scaling of the location of this inflection point with the dimensionless lengths of the problem. Eventually, we provide key elements for optimization of the reactor.

  20. Active magneto-optical control of spontaneous emission in graphene

    E-Print Network [OSTI]

    Kort-Kamp, W J M; Bastos, G; Pinheiro, F A; Rosa, F S S; Peres, N M R; Farina, C

    2015-01-01T23:59:59.000Z

    We investigate the spontaneous emission rate of a two-level quantum emitter near a graphene-coated substrate under the influence of an external magnetic field. We demonstrate that the application of the magnetic field can substantially increase or decrease the decay rate. We show that a suppression as large as 99$\\%$ in the Purcell factor is achieved even for moderate magnetic fields. The emitter's lifetime is a discontinuous function of $|{\\bf B}|$, which is a direct consequence of the occurrence of discrete Landau levels in graphene. We demonstrate that, in the near-field regime, the magnetic field enables an unprecedented control of the decay pathways into which the photon/polariton can be emitted. Our findings strongly suggest that a magnetic field could act as an efficient agent for on-demand, active control of light-matter interactions in graphene at the quantum level.

  1. Waste management activities and carbon emissions in Africa

    SciTech Connect (OSTI)

    Couth, R. [University of KwaZulu-Natal, CRECHE, School of Civil Engineering, Survey and Construction, Durban 4041 (South Africa); Trois, C., E-mail: troisc@ukzn.ac.za [University of KwaZulu-Natal, CRECHE, School of Civil Engineering, Survey and Construction, Durban 4041 (South Africa)

    2011-01-15T23:59:59.000Z

    This paper summarizes research into waste management activities and carbon emissions from territories in sub-Saharan Africa with the main objective of quantifying emission reductions (ERs) that can be gained through viable improvements to waste management in Africa. It demonstrates that data on waste and carbon emissions is poor and generally inadequate for prediction models. The paper shows that the amount of waste produced and its composition are linked to national Gross Domestic Product (GDP). Waste production per person is around half that in developed countries with a mean around 230 kg/hd/yr. Sub-Saharan territories produce waste with a biogenic carbon content of around 56% (+/-25%), which is approximately 40% greater than developed countries. This waste is disposed in uncontrolled dumps that produce large amounts of methane gas. Greenhouse gas (GHG) emissions from waste will rise with increasing urbanization and can only be controlled through funding mechanisms from developed countries.

  2. Active optical fibres in modern particle physics experiments

    E-Print Network [OSTI]

    C. P. Achenbach

    2004-04-05T23:59:59.000Z

    In modern particle physics experiments wavelength-shifting and scintillating fibres based on plastic polymers are used for tracking and calorimetry. In this review the role of photon trapping efficiencies, transmission functions and signal response times for common multimode active fibres is discussed. Numerical simulations involving three dimensional tracking of skew rays through curved fibres demonstrate the characteristics of trapped light. Of practical interest are the parametrisations of transmission functions and the minimum permissible radius of curvature. These are of great importance in today's experiments where high count rates and small numbers of photoelectrons are encountered. Special emphasis has been placed on the timing resolution of fibre detectors and its limitation due to variations in the path length of generated photons.

  3. Active doublet method for measuring small changes in physical properties

    DOE Patents [OSTI]

    Roberts, Peter M. (Los Alamos, NM); Fehler, Michael C. (Los Alamos, NM); Johnson, Paul A. (Santa Fe, NM); Phillips, W. Scott (Santa Fe, NM)

    1994-01-01T23:59:59.000Z

    Small changes in material properties of a work piece are detected by measuring small changes in elastic wave velocity and attenuation within a work piece. Active, repeatable source generate coda wave responses from a work piece, where the coda wave responses are temporally displaced. By analyzing progressive relative phase and amplitude changes between the coda wave responses as a function of elapsed time, accurate determinations of velocity and attenuation changes are made. Thus, a small change in velocity occurring within a sample region during the time periods between excitation origin times (herein called "doublets") will produce a relative delay that changes with elapsed time over some portion of the scattered waves. This trend of changing delay is easier to detect than an isolated delay based on a single arrival and provides a direct measure of elastic wave velocity changes arising from changed material properties of the work piece.

  4. The Enzyme-mimic Activity of Ferric Nano-Core Residing in Ferritin...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The Enzyme-mimic Activity of Ferric Nano-Core Residing in Ferritin and Its Biosensing Applications. The Enzyme-mimic Activity of Ferric Nano-Core Residing in Ferritin and Its...

  5. Evidence for compact structuring in the corona of active stars

    E-Print Network [OSTI]

    F. Favata

    2000-11-27T23:59:59.000Z

    The ``current wisdom'' regarding the structuring of the X-ray emitting corona in active stars (i.e. a corona dominated by extended coronal structures) is briefly reviewed, followed by a review of a new approach to flare analysis and the analysis of a significant number of newly observed and previously published large flares, all leading to a much more compactly structured corona. Recent observations showing the polar location of the flaring plasma are then discussed, showing how the current evidence points toward a (flaring) corona composed of rather low-lying polar structures, also in agreement with some recent radio VLBI observational results and with starspot Doppler images. The resulting picture is significantly different from the solar case.

  6. A Look at Principal Building Activities in Commercial Buildings

    Gasoline and Diesel Fuel Update (EIA)

    Buildings Home> Special Topics > 1995 Principal Building Activities Office Education Health Care Retail and Service Food Service Food Sales Lodging Religious Worship Public...

  7. Activities in History of Mathematics in Utrecht and Leiden in the year 2005

    E-Print Network [OSTI]

    Hogendijk, Jan P.

    Activities in History of Mathematics in Utrecht and Leiden in the year 2005 Contents: · Personnel in the Department of Mathematics of Utrecht University. · Jeanine Daems (JD): 1.0 Ph.D. student in Leiden University P. Hogendijk (JH) worked in the Department of Mathematics of Utrecht University in the following

  8. Measurement and Verification Activities Required in the Energy Savings Performance Contract Process

    Broader source: Energy.gov [DOE]

    There are four major measurement and verification (M&V) activities in the energy savings performance contract (ESPC) procurement process.

  9. Silicate emissions in active galaxies - From LINERs to QSOs

    E-Print Network [OSTI]

    E. Sturm; M. Schweitzer; D. Lutz; A. Contursi; R. Genzel; M. D. Lehnert; L. J. Tacconi; S. Veilleux; D. S. Rupke; D. -C. Kim; A. Sternberg; D. Maoz; S. Lord; J. Mazzarella; D. B. Sanders

    2005-06-29T23:59:59.000Z

    We report the first detection of ~10 and ~18 micron silicate dust emissions in a low-luminosity active galactic nucleus (AGN), obtained in Spitzer-IRS 7-37 micron spectroscopy of the Type 1 LINER galaxy NGC3998. Silicate emissions in AGN have only recently been detected in several quasars. Our detection counters suggestions that silicate emissions are present only in the most luminous AGN. The silicate features may be signatures of a dusty ``obscuring torus'' viewed face-on as postulated for Type 1 AGN. However, the apparently cool (~200 K) dust is inconsistent with theoretical expectations of much hotter torus walls. Furthermore, not all Type 1 objects are silicate emission sources. Alternatively, the silicate emission may originate in dust not directly associated with a torus. We find that the long-wavelength (>20 micron) tail of the emission in NGC3998 is significantly weaker than in the sample of bright QSOs recently presented by Hao et al. The 10 micron profile in our NGC3998 spectrum is inconsistent with ``standard'' silicate ISM dust. This may indicate differences in the dust composition, grain size distribution, or degree of crystallization. The differences between NGC3998, QSOs, and Galactic templates suggest that there are significant environmental variations.

  10. Effect of cellular differentiation on 11 -hydroxysteroid dehydrogenase activity in the intestine

    E-Print Network [OSTI]

    Miksik, Ivan

    lines derived from rat small intestine (IEC-6, IEC-18) and from human colon adenocarcinoma (Caco-2, HT activity was observed in HT-29 cells, and lowest activity was seen in IEC cells. Treatment with dexamethasone (50 nM) increased the activity of 11 HSD2 in IEC-6 cells ( 59%) and HT-29 cells ( 31%), whereas

  11. Decreased dopamine activity predicts relapse in methamphetamine abusers

    SciTech Connect (OSTI)

    Wang G. J.; Wang, G.-J.; Smith, L.; Volkow, N.D.; Telang, F.; Logan, J.; Tomasi, D.; Wong, C.T.; Hoffman, W.; Jayne, M.; Alia-Klein, N.; Thanos, P.; Fowler, J.S.

    2011-01-20T23:59:59.000Z

    Studies in methamphetamine (METH) abusers showed that the decreases in brain dopamine (DA) function might recover with protracted detoxification. However, the extent to which striatal DA function in METH predicts recovery has not been evaluated. Here we assessed whether striatal DA activity in METH abusers is associated with clinical outcomes. Brain DA D2 receptor (D2R) availability was measured with positron emission tomography and [{sup 11}C]raclopride in 16 METH abusers, both after placebo and after challenge with 60 mg oral methylphenidate (MPH) (to measure DA release) to assess whether it predicted clinical outcomes. For this purpose, METH abusers were tested within 6 months of last METH use and then followed up for 9 months of abstinence. In parallel, 15 healthy controls were tested. METH abusers had lower D2R availability in caudate than in controls. Both METH abusers and controls showed decreased striatal D2R availability after MPH and these decreases were smaller in METH than in controls in left putamen. The six METH abusers who relapsed during the follow-up period had lower D2R availability in dorsal striatum than in controls, and had no D2R changes after MPH challenge. The 10 METH abusers who completed detoxification did not differ from controls neither in striatal D2R availability nor in MPH-induced striatal DA changes. These results provide preliminary evidence that low striatal DA function in METH abusers is associated with a greater likelihood of relapse during treatment. Detection of the extent of DA dysfunction may be helpful in predicting therapeutic outcomes.

  12. Measurement of chlorite dismutase activities in perchlorate respiring bacteria

    E-Print Network [OSTI]

    concentration (0.6 mM) to four other perchlorate respiring bacteria (PRB), and to one non-PRB (Pseudomonas aeruginosa). Chlorate-grown cultures of the five PRB strains had CD activities ranging from 25 to 50 U/mg of cell dry weight (DW), while aerobically grown cultures of the PRB had much lower CD activities (0.5­4 U

  13. Patterns of Arm Muscle Activation Involved in Octopus Reaching Movements

    E-Print Network [OSTI]

    Hochner, Binyamin

    (EMG)] was measured together with the kinematics of reaching movements. The traveling bend is associated with a propagat- ing wave of muscle activation, with maximal muscle activation slightly preceding with the kinematic variables (velocities and accelerations) re- veals that a significant part of the kinematic

  14. BNL ACTIVITIES IN ADVANCED NEUTRON SOURCE DEVELOPMENT: PAST AND PRESENT

    SciTech Connect (OSTI)

    HASTINGS,J.B.; LUDEWIG,H.; MONTANEZ,P.; TODOSOW,M.; SMITH,G.C.; LARESE,J.Z.

    1998-06-14T23:59:59.000Z

    Brookhaven National Laboratory has been involved in advanced neutron sources almost from its inception in 1947. These efforts have mainly focused on steady state reactors beginning with the construction of the first research reactor for neutron beams, the Brookhaven Graphite Research Reactor. This was followed by the High Flux Beam Reactor that has served as the design standard for all the subsequent high flux reactors constructed worldwide. In parallel with the reactor developments BNL has focused on the construction and use of high energy proton accelerators. The first machine to operate over 1 GeV in the world was the Cosmotron. The machine that followed this, the AGS, is still operating and is the highest intensity proton machine in the world and has nucleated an international collaboration investigating liquid metal targets for next generation pulsed spallation sources. Early work using the Cosmotron focused on spallation product studies for both light and heavy elements into the several GeV proton energy region. These original studies are still important today. In the sections below the authors discuss the facilities and activities at BNL focused on advanced neutron sources. BNL is involved in the proton source for the Spallation Neutron source, spectrometer development at LANSCE, target studies using the AGS and state-of-the-art neutron detector development.

  15. BNL Activities in Advanced Neutron Source Development: Past and Present

    SciTech Connect (OSTI)

    Hastings, J.B.; Ludewig, H.; Montanez, P.; Todosow, M.; Smith, G.C.; Larese, J.Z.

    1998-06-14T23:59:59.000Z

    Brookhaven National Laboratory has been involved in advanced neutron sources almost from its inception in 1947. These efforts have mainly focused on steady state reactors beginning with the construction of the first research reactor for neutron beams, the Brookhaven Graphite Research Reactor. This was followed by the High Flux Beam Reactor that has served as the design standard for all the subsequent high flux reactors constructed worldwide. In parallel with the reactor developments BNL has focused on the construction and use of high energy proton accelerators. The first machine to operate over 1 GeV in the world was the Cosmotron. The machine that followed this, the AGS, is still operating and is the highest intensity proton machine in the world and has nucleated an international collaboration investigating liquid metal targets for next generation pulsed spallation sources. Early work using the Cosmotron focused on spallation product studies for both light and heavy elements into the several GeV proton energy region. These original studies are still important today. In this report we discuss the facilities and activities at BNL focused on advanced neutron sources. BNL is involved in the proton source for the Spallation Neutron source, spectrometer development at LANSCE, target studies using the AGS and state-of-the-art neutron detector development.

  16. Spin orientation of supermassive black holes in active galaxies

    E-Print Network [OSTI]

    W. Kollatschny

    2003-11-12T23:59:59.000Z

    Accretion of gas onto a central supermassive black hole is generally accepted to be the source of the emitted energy in active galactic nuclei.The broad emission lines we observe in their optical spectra are probably formed in the wind of an accretion disk at distances of light days to light years from the central black hole. The variable fraction of the emission lines originates at typical distances of only 1 to 50 light days from the central supermassive black hole. We derived a central black hole mass of M_orbital = 1.8 +/-0.4 x 10^7 M_sun in the Seyfert galaxy Mrk110 assuming the broad emission lines are generated in gas clouds orbiting within an accretion disk. This figure depends on the inclination angle of the accretion disk. Here we report on the detection of gravitational redshifted emission in the variable fraction of the broad emission lines. We derive a central black hole mass of M_grav = 14.0 +/-3.0 x 10^7 M_sun. These measurements are independent on the orientation of the accretion disk. The comparison of both black hole mass estimates allows to determine the projection of the central accretion disk angle i to 21 +/-5 deg. in Mrk110 and therefore the orientation of the spin axis of the central black hole.

  17. The role of filament activation in a solar eruption

    E-Print Network [OSTI]

    da Costa, Fatima Rubio; Fletcher, Lyndsay; Romano, Paolo; Labrosse, Nicolas

    2014-01-01T23:59:59.000Z

    Observations show that the mutual relationship between filament eruptions and solar flares cannot be described in terms of an unique scenario. In some cases, the eruption of a filament appears to trigger a flare, while in others the observations are more consistent with magnetic reconnection that produces both the flare observational signatures (e.g., ribbons, plasma jets, post-flare loops, etc.) and later the destabilization and eruption of a filament. We study an event which occurred in NOAA 8471, where a flare and the activation of (at least) two filaments were observed on 28 February 1999. By using imaging data acquired in the 1216, 1600, 171 and 195 \\AA\\ TRACE channels and by BBSO in the continnum and in H$\\alpha$, a morphological study of the event is carried out. Using TRACE 1216 and 1600 \\AA\\ data, an estimate of the "pure" Ly$\\alpha$ power is obtained. The extrapolation of the magnetic field lines is done using the SOHO/MDI magnetograms and assuming a potential field. The potential magnetic field ext...

  18. The origin of net electric currents in solar active regions

    E-Print Network [OSTI]

    Dalmasse, K; Démoulin, P; Kliem, B; Török, T; Pariat, E

    2015-01-01T23:59:59.000Z

    There is a recurring question in solar physics about whether or not electric currents are neutralized in active regions (ARs). This question was recently revisited using three-dimensional (3D) magnetohydrodynamic (MHD) numerical simulations of magnetic flux emergence into the solar atmosphere. Such simulations showed that flux emergence can generate a substantial net current in ARs. Another source of AR currents are photospheric horizontal flows. Our aim is to determine the conditions for the occurrence of net vs. neutralized currents with this second mechanism. Using 3D MHD simulations, we systematically impose line-tied, quasi-static, photospheric twisting and shearing motions to a bipolar potential magnetic field. We find that such flows: (1) produce both {\\it direct} and {\\it return} currents, (2) induce very weak compression currents - not observed in 2.5D - in the ambient field present in the close vicinity of the current-carrying field, and (3) can generate force-free magnetic fields with a net current...

  19. Effects of Pinealectomy on Metabolic Activity and Clock Gene Expression in Passer domesticus

    E-Print Network [OSTI]

    McCormick, Ryan

    2008-08-19T23:59:59.000Z

    coupled oscillatory mechanisms. To this end, we utilized activity-monitoring equipment to measure locomotor activity; 2DG uptake was measured via autoradiography and scintillation counts in the brain and peripheral tissues, respectively; and clock gene...

  20. Activities in History of Mathematics in Utrecht in the year Personnel

    E-Print Network [OSTI]

    Hogendijk, Jan P.

    Activities in History of Mathematics in Utrecht in the year 2011 Contents: · Personnel · National of Mathematics in Utrecht University (0,5 full professor, 0,5 associate professor). Mr. Goossen Karssenberg (GK, was awarded a prize because of the project she did in Utrecht and therefore she will be mentioned

  1. Total nitrogen removal in a hybrid, membrane-aerated activated sludge process

    E-Print Network [OSTI]

    Nerenberg, Robert

    Total nitrogen removal in a hybrid, membrane-aerated activated sludge process Leon S. Downing wastewater. Air-filled hollow-fiber membranes are incorporated into an activated sludge tank removal in activated sludge. ª 2008 Elsevier Ltd. All rights reserved. 1. Introduction The removal

  2. Uncharted Microbial World: Microbes and Their Activities in the Environment

    SciTech Connect (OSTI)

    Harwood, Caroline; Buckley, Merry.

    2007-12-31T23:59:59.000Z

    Microbes are the foundation for all of life. From the air we breathe to the soil we rely on for farming to the water we drink, everything humans need to survive is intimately coupled with the activities of microbes. Major advances have been made in the understanding of disease and the use of microorganisms in the industrial production of drugs, food products and wastewater treatment. However, our understanding of many complicated microbial environments (the gut and teeth), soil fertility, and biogeochemical cycles of the elements is lagging behind due to their enormous complexity. Inadequate technology and limited resources have stymied many lines of investigation. Today, most environmental microorganisms have yet to be isolated and identified, let alone rigorously studied. The American Academy of Microbiology convened a colloquium in Seattle, Washington, in February 2007, to deliberate the way forward in the study of microorganisms and microbial activities in the environment. Researchers in microbiology, marine science, pathobiology, evolutionary biology, medicine, engineering, and other fields discussed ways to build on and extend recent successes in microbiology. The participants made specific recommendations for targeting future research, improving methodologies and techniques, and enhancing training and collaboration in the field. Microbiology has made a great deal of progress in the past 100 years, and the useful applications for these new discoveries are numerous. Microorganisms and microbial products are now used in industrial capacities ranging from bioremediation of toxic chemicals to probiotic therapies for humans and livestock. On the medical front, studies of microbial communities have revealed, among other things, new ways for controlling human pathogens. The immediate future for research in this field is extremely promising. In order to optimize the effectiveness of community research efforts in the future, scientists should include manageable systems with features like clear physical boundaries, limited microbial diversity, and manipulability with the goal of understanding fundamental principles that may apply to more complex systems. A great deal of microbial genetic and phenotypic diversity remains to be explored, and the commercial and medical potential locked up in these unknowns should compel the field to move forward. Future microbiology research will build on the successes of the past using new techniques and approaches. Uncultivated microbes hold great promise for industry, medicine, and the recycling of precious resources, and research and technology must make inroads in overcoming the barriers that prevent their study. In many cases, we will no longer be able to rely on isolated, pure cultures of microorganisms, but must use communities of microorganisms, which presently are poorly understood. Indeed, community-level studies can benefit from deconstructing microbial communities and analyzing the component members separately, but this is not feasible in every system. The effects of perturbation on microbial communities also require study. Humans rely on the services of microbes in innumerable ways, but we have little or no predictive understanding of how microbial communities respond to disturbance. Research must address current limitations in detecting microscale interactions among microbes by enhancing current technologies and fostering new microscopic tools, biosensors, and gas sensors for appropriate small scales. Genomics, which has enabled great progress in microbiology research of individual species, must be applied to communities of microorganisms. This will require improved methods of DNA extraction and amplification from environmental samples and improved strategies for DNA sequence assembly. In the future, genome sequencing efforts should continue the exploration of evolutionarily diverse microbes, as well as help reveal the mechanisms by which closely related microbes evolve. Technological advances have spurred every great leap in microbial biology, and in order to move forward, new m

  3. Record-breaking Storm Activity on Uranus in 2014

    E-Print Network [OSTI]

    de Pater, Imke; Fry, P M; Hammel, Heidi B; Baranec, Christoph; Sayanagi, Kunio

    2015-01-01T23:59:59.000Z

    In spite of an expected decline in convective activity following the 2007 equinox of Uranus, eight sizable storms were detected on the planet with the near-infrared camera NIRC2, coupled to the adaptive optics system, on the 10-m W. M. Keck telescope on UT 5 and 6 August 2014. All storms were on Uranus's northern hemisphere, including the brightest storm ever seen in this planet at 2.2 $\\mu$m, reflecting 30% as much light as the rest of the planet at this wavelength. The storm was at a planetocentric latitude of $\\sim$15$^{\\circ}$N and reached altitudes of $\\sim$330 mbar, well above the regular uppermost cloud layer (methane-ice) in the atmosphere. A cloud feature at a latitude of 32$^{\\circ}$N, that was deeper in the atmosphere (near $\\sim$2 bar), was later seen by amateur astronomers. We also present images returned from our HST ToO program, that shows both of these cloud features. We further report the first detection of a long-awaited haze over the north polar region.

  4. SOLAR ROTATION RATE DURING THE CYCLE 24 MINIMUM IN ACTIVITY

    SciTech Connect (OSTI)

    Antia, H. M. [Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400005 (India); Basu, Sarbani, E-mail: antia@tifr.res.i, E-mail: sarbani.basu@yale.ed [Department of Astronomy, Yale University, P.O. Box 208101, New Haven CT 06520-8101 (United States)

    2010-09-01T23:59:59.000Z

    The minimum of solar cycle 24 is significantly different from most other minima in terms of its duration as well as its abnormally low levels of activity. Using available helioseismic data that cover epochs from the minimum of cycle 23 to now, we study the differences in the nature of the solar rotation between the minima of cycles 23 and 24. We find that there are significant differences between the rotation rates during the two minima. There are differences in the zonal-flow pattern too. We find that the band of fast rotating region close to the equator bifurcated around 2005 and recombined by 2008. This behavior is different from that during the cycle 23 minimum. By autocorrelating the zonal-flow pattern with a time shift, we find that in terms of solar dynamics, solar cycle 23 lasted for a period of 11.7 years, consistent with the result of Howe et al. (2009). The autocorrelation coefficient also confirms that the zonal-flow pattern penetrates through the convection zone.

  5. SLOW MAGNETOSONIC WAVES AND FAST FLOWS IN ACTIVE REGION LOOPS

    SciTech Connect (OSTI)

    Ofman, L.; Wang, T. J. [Department of Physics, Catholic University of America, Washington, DC 20064 (United States); Davila, J. M. [NASA Goddard Space Flight Center, Code 671, Greenbelt, MD 20771 (United States)

    2012-08-01T23:59:59.000Z

    Recent extreme ultraviolet spectroscopic observations indicate that slow magnetosonic waves are present in active region (AR) loops. Some of the spectral data were also interpreted as evidence of fast ({approx}100-300 km s{sup -1}) quasi-periodic flows. We have performed three-dimensional magnetohydrodynamic (3D MHD) modeling of a bipolar AR that contains impulsively generated waves and flows in coronal loops. The model AR is initiated with a dipole magnetic field and gravitationally stratified density, with an upflow-driven steadily or periodically in localized regions at the footpoints of magnetic loops. The resulting flows along the magnetic field lines of the AR produce higher density loops compared to the surrounding plasma by injection of material into the flux tubes and the establishment of siphon flow. We find that the impulsive onset of flows with subsonic speeds result in the excitation of damped slow magnetosonic waves that propagate along the loops and coupled nonlinearly driven fast-mode waves. The phase speed of the slow magnetosonic waves is close to the coronal sound speed. When the amplitude of the driving pulses is increased we find that slow shock-like wave trains are produced. When the upflows are driven periodically, undamped oscillations are produced with periods determined by the periodicity of the upflows. Based on the results of the 3D MHD model we suggest that the observed slow magnetosonic waves and persistent upflows may be produced by the same impulsive events at the bases of ARs.

  6. Laser stimulation can activate autophagy in HeLa cells

    SciTech Connect (OSTI)

    Wang, Yisen; Hu, Minglie; Wang, Chingyue [Ultrafast Laser Laboratory, Key Laboratory of Optoelectronic Information Technology (Ministry of Education), College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin (China); Lan, Bei; Cao, Youjia [Key Laboratory of Microbial Functional Genomics of Ministry of Education, College of Life Sciences, Nankai University, Tianjin (China); He, Hao, E-mail: haohe@tju.edu.cn [Ultrafast Laser Laboratory, Key Laboratory of Optoelectronic Information Technology (Ministry of Education), College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin (China); Med-X Research Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai (China)

    2014-10-27T23:59:59.000Z

    For decades, lasers have been a daily tool in most biological research for fluorescent excitation by confocal or multiphoton microscopy. More than 20 years ago, cell photodamage caused by intense laser stimulation was noticed by generating reactive oxygen species, which was then thought as the main damage effect by photons. In this study, we show that laser stimulation can induce autophagy, an important cell lysosomal pathway responding to immune stimulation and starvation, without any biochemical treatment. Two different types of laser stimulations are found to be capable of activating autophagy: continuous scanning by continuous-wave visible lasers and a short-time flash of femtosecond laser irradiation. The autophagy generation is independent from wavelength, power, and scanning duration of the visible lasers. In contrast, the power of femtosecond laser is very critical to autophagy because the multiphoton excited Ca{sup 2+} dominates autophagy signaling. In general, we show here the different mechanisms of autophagy generation by such laser stimulation, which correspond to confocal microscopy and cell surgery, respectively. Those results can help further understanding of photodamage and autophagy signaling.

  7. Activities in History of Mathematics in Utrecht and Leiden in the year 2006

    E-Print Network [OSTI]

    Hogendijk, Jan P.

    Activities in History of Mathematics in Utrecht and Leiden in the year 2006 Contents: · Personnel): 0.5 Full Professor in History of Mathematics and 0.3 Associate Professor (UHD) at Utrecht University of Mathematics of Utrecht University (0,8) and the International Institute for Asian Studies at Leiden (0

  8. Germ cells of the centipede Strigamia maritima are specified early in embryonic development

    E-Print Network [OSTI]

    Green, Jack E.; Akam, Michael

    2014-06-12T23:59:59.000Z

    until they reach the gonad, and provides little or no evidence for this description in the accompanying figures. Given the ambiguity, previous surveys of germ cell development have con- cluded that centipede PGCs arise late in embryogenesis from gonadal... (Thermo Scientific). The product of cDNA synthesis reaction in which no RNA had been added to the reaction was used as a no template control. Primer sequences used to detect nanos2, vasa, bra1, en and tubulin are provided in Supplementary Table 2. All...

  9. Effects of oxygen transport limitation on nitrification in the activated sludge process

    E-Print Network [OSTI]

    Stenstrom, Michael K.

    Effects of oxygen transport limitation on nitrification in the activated sludge process ABSTRACT: Apseudohomogeneous model ofthe nitrifying activated sludge process was developed to investigate the effects ofmass and autotrophic ammonia oxidation within activated sludge flocs were described by an interactive-type, multiple

  10. Optimization of Power in the Problems of Active Control of Sound ?

    E-Print Network [OSTI]

    Optimization of Power in the Problems of Active Control of Sound ? J. Lon#20;cari#19;c 1 Los Alamos- dered by active means, i.e., by introducing the additional acoustic sources called controls that generate the appropriate anti-sound. Previously, we have obtained general solutions for active controls

  11. Theoretical Modeling Issue in Active Noise Control for a One-Dimensional Acoustic Duct System

    E-Print Network [OSTI]

    Yang, Zhenyu

    Theoretical Modeling Issue in Active Noise Control for a One-Dimensional Acoustic Duct System-6700 Esbjerg, Denmark Email: yang,sp@aaue.dk Abstract--The theoretical modeling of active noise control for the entire one-dimensional active duct noise control system is obtained and validated. The developed model

  12. A Robust Aggregation Method for Quasi-blind Robots in an Active Environment

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    A Robust Aggregation Method for Quasi-blind Robots in an Active Environment Nazim Fat is through an active environment (stigmergy) and the only information they can receive is the local detection of the waves produced by other robots. The active environment obeys a cellular automaton rule and is simulated

  13. Waste Minimization Plans and activities in the MFD Plating Shop

    SciTech Connect (OSTI)

    Dini, J.W.; Steffani, C.P.

    1991-02-01T23:59:59.000Z

    The Plating Shop (Building 322), provides processes such as electroplating, electroless plating, anodizing, cleaning, etching, electroforming and chemical milling. We in MFD are committed to an active program on waste minimization, and the purpose of this document is to outline the plan of action. Our short range minimization goals are threefold: (1) Reduce our major waste stream by 90%, (2) Minimize discharge of rinse water to sewer system, and (3) Eliminate vapor degreasing in the shop. The intermediate goals consist of characterizing the waste streams and evaluating recovery processes. To do this, we first need to have the distillation unit operational and time to determine its effectiveness. If it proves to be as effective as we anticipate, we will perhaps purchase a second unit. Regardless, the streams that we can identify include: nickel, copper, rinses, acids, alkalies, electropolish and miscellaneous. Our goal is to utilize electrolytic processes to recover metals such as nickel and copper and processes such as ion exchange for some of the other streams. We intend to evaluate the full gamut of recycling processes available for these streams. We anticipate completing this phase of the minimization program by January 1993. The long range goal is zero discharge or since this could prove extremely difficult, development of processes that will allow us to produce a sludge cake that could be handled by our Hazardous Waste Management Group.

  14. Democratizing Mobile Technology in Support of Volunteer Activities in Data Collection

    E-Print Network [OSTI]

    Democratizing Mobile Technology in Support of Volunteer Activities in Data Collection Sun Young Kim-computer interaction, mobile technology, technology adoption, volunteer, data collection, citizen science, participatory sensing, sustainability #12;III ABSTRACT Mobile technology is advancing our ability to connect

  15. Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma

    E-Print Network [OSTI]

    Litonjua, Augusto A

    Background: Identifying genetic determinants for lung function is important in providing insight into the pathophysiology of asthma. Signal transducer and activator of transcription 3 is a transcription factor latent in ...

  16. Summary of ICTP activities in support of science in

    E-Print Network [OSTI]

    2002 Evgeny Pavlovic Velikhov, Russian Academy of Sciences Visited ICTP in 2007, G8 UNESCO Forum Visited ICTP in 2007, G8-UNESCO World Forum on 'Education, Research and Innovation: New Partnership

  17. Summary of ICTP activities in support of science in Ecuador

    E-Print Network [OSTI]

    's Scientific Meetings #12;} Joint ICTP-TWAS Workshop on Climate Change in Mediterranean and Caribbean Seas

  18. Activities of the U. S. Department of Energy in education. Annual status report, FY 1979

    SciTech Connect (OSTI)

    Not Available

    1980-04-01T23:59:59.000Z

    The energy-related education activities administered in FY 1979 by DOE are described: projections for FY 1980 are also given. This document provides assistance for DOE program managers who wish to use the educational process in their operations, and it provides guidance and information to educators and the general public about DOE energy-related education activities. The education activities are classified as energy information (curriculum packages, studies, workshops and forums conferences, other materials), energy skills development, institutional resource enhancement, and other activities. A chart gives the category of activity, type of audience, and type of services provided. (RWR)

  19. U.S. Department of Energy -- Advanced Vehicle Testing Activity: Plug-in Hybrid Electric Vehicle Testing and Demonstration Activities

    SciTech Connect (OSTI)

    James E. Francfort; Donald Karner; John G. Smart

    2009-05-01T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) Advanced Vehicle Testing Activity (AVTA) tests plug-in hybrid electric vehicles (PHEV) in closed track, dynamometer and onroad testing environments. The onroad testing includes the use of dedicated drivers on repeated urban and highway driving cycles that range from 10 to 200 miles, with recharging between each loop. Fleet demonstrations with onboard data collectors are also ongoing with PHEVs operating in several dozen states and Canadian Provinces, during which trips- and miles-per-charge, charging demand and energy profiles, and miles-per-gallon and miles-per-kilowatt-hour fuel use results are all documented, allowing an understanding of fuel use when vehicles are operated in charge depleting, charge sustaining, and mixed charge modes. The intent of the PHEV testing includes documenting the petroleum reduction potential of the PHEV concept, the infrastructure requirements, and operator recharging influences and profiles. As of May 2008, the AVTA has conducted track and dynamometer testing on six PHEV conversion models and fleet testing on 70 PHEVs representing nine PHEV conversion models. A total of 150 PHEVs will be in fleet testing by the end of 2008, all with onboard data loggers. The onroad testing to date has demonstrated 100+ miles per gallon results in mostly urban applications for approximately the first 40 miles of PHEV operations. The primary goal of the AVTA is to provide advanced technology vehicle performance benchmark data for technology modelers, research and development programs, and technology goal setters. The AVTA testing results also assist fleet managers in making informed vehicle purchase, deployment and operating decisions. The AVTA is part of DOE’s Vehicle Technologies Program. These AVTA testing activities are conducted by the Idaho National Laboratory and Electric Transportation Engineering Corporation, with Argonne National Laboratory providing dynamometer testing support. The proposed paper and presentation will discuss PHEV testing activities and results. INL/CON-08-14333

  20. Lipolytic activity in whole, skim, and cream fractions of temperature activated milk

    E-Print Network [OSTI]

    Wang, Liangen

    1976-01-01T23:59:59.000Z

    in Ililk. I, 'esture and Distributio. . . Origin. Distribution. Ii'umber. Purification and Characterization. Properties. Specificity. PH optima. Temperature optima. I'actors Affectino Lipolysis. F rm Factors. Physiolooical condIitions. Ration... substrates~ vari ble pH optima:!ith different concentrations of substrate! and chang'e:ble ranges of temperatt ure optima! most -. , ; e tigators (39, 40! 52! 84! 85' 102) . -, pport the ries! that milk contai?s a rvltiple lip se system On the o'I cr I...

  1. Radiocaesium Activity Concentrations in Potatoes in Croatia after the Chernobyl Accident and Dose Assessment

    E-Print Network [OSTI]

    Franic, Z; Marovic, G; Petrinec, B

    2007-01-01T23:59:59.000Z

    Systematic investigations of 137Cs and 134Cs activity concentrations in potatoes (Solanum tuberosum) for the post-Chernobyl period (1986-2005) in the Republic of Croatia are summarized. The correlation between 137Cs activity concentrations in fallout and potatoes, has been found to be very good, the correlation coefficient being r2=0.88 with P(t) Chernobyl reactor to the equation for the differential radioactive decay. Thi...

  2. Equipment Availability in the Home and School Environment: Its Relationship on Physical Activity in Children 

    E-Print Network [OSTI]

    Montandon, Kristi

    2013-01-14T23:59:59.000Z

    where children spend the major of time, home and school, were evaluated for equipment availability and increased physical activity. Three studies were conducted to complete this purpose. In Manuscript 1, a systematic literature review was conducted...

  3. Aggregate Dynamics in a Large Virtual Economy: Prices and Real Activity in Team Fortress 2*

    E-Print Network [OSTI]

    Baumer, Matt; Kephart, Curtis

    2015-01-01T23:59:59.000Z

    Prices and Real Activity in Team Fortress 2 ? Matt Baumer †is the virtual economy of Team Fortress 2 (TF2) developedvalue. Environment and Data Team Fortress 2 is a competitive

  4. Role of peroxisome proliferator-activated receptors in mechanisms of rejection in heart transplantation

    E-Print Network [OSTI]

    Binello, Emanuela

    2004-01-01T23:59:59.000Z

    Peroxisome proliferator-activated receptors (PPARs) belong to a nuclear receptor superfamily; two major isoforms, PPAR? and PPAR[gamma], are primarily involved in lipid and glucose homeostasis. However, evidence also ...

  5. THE LIMIT OF MAGNETIC-SHEAR ENERGY IN SOLAR ACTIVE REGIONS

    SciTech Connect (OSTI)

    Moore, Ronald L.; Falconer, David A.; Sterling, Alphonse C., E-mail: ron.moore@nasa.gov [Heliophysics and Planetary Science Office, ZP13, Marshall Space Flight Center, Huntsville, AL 35812 (United States)

    2012-05-01T23:59:59.000Z

    It has been found previously, by measuring from active-region magnetograms a proxy of the free energy in the active region's magnetic field, (1) that there is a sharp upper limit to the free energy the field can hold that increases with the amount of magnetic field in the active region, the active region's magnetic flux content, and (2) that most active regions are near this limit when their field explodes in a coronal mass ejection/flare eruption. That is, explosive active regions are concentrated in a main-sequence path bordering the free-energy-limit line in (flux content, free-energy proxy) phase space. Here, we present evidence that specifies the underlying magnetic condition that gives rise to the free-energy limit and the accompanying main sequence of explosive active regions. Using a suitable free-energy proxy measured from vector magnetograms of 44 active regions, we find evidence that (1) in active regions at and near their free-energy limit, the ratio of magnetic-shear free energy to the non-free magnetic energy the potential field would have is of the order of one in the core field, the field rooted along the neutral line, and (2) this ratio is progressively less in active regions progressively farther below their free-energy limit. Evidently, most active regions in which this core-field energy ratio is much less than one cannot be triggered to explode; as this ratio approaches one, most active regions become capable of exploding; and when this ratio is one, most active regions are compelled to explode.

  6. Active Probing Approach for Fault Localization in Computer Networks*

    E-Print Network [OSTI]

    Sethi, Adarshpal

    to develop tools for performing fault localization. We discuss various design issues involved and propose architecture for building such a tool. We describe an algorithm for probe set selection for problem detection a wide range of activities involving network design and operation [7, 9, 17, 18]. Network monitoring can

  7. Pseudorabies Virus Infection Alters Neuronal Activity and Connectivity In Vitro

    E-Print Network [OSTI]

    Tank, David

    on motor and sensory neuron activity. For example, herpes simplex virus type 1 causes herpes labialis-herpesviruses, including human herpes simplex virus 1 & 2, varicella zoster virus and the swine pseudorabies virus (PRV with the sensations of numbness and tingling [1]; herpes simplex virus type 2 causes genital herpes

  8. Energy and Development: Activities in Sub-Saharan Africa

    E-Print Network [OSTI]

    reductionHealth Solar Water Heater Women Renewable EnergyProject RemarksSubstantiation Case Study findings systematic description of an energy intervention and its consequences common approach #12;Activity Solar Hot Water Output Hot Water Job Creation Energy Services Utilization of hot water for showering Outcome Wood

  9. Protease-Activated Receptor-2 in the Intestinal Epithelium & Differential Effects of Beta Arrestins on the Internalization, Desensitization & ERK 1/2 Activation Downstream of Protease-Activated Receptor-2

    E-Print Network [OSTI]

    Lau, Chang Shun

    2010-01-01T23:59:59.000Z

    an increase in short circuit current while activation ofactivation increased short circuit current via induction of750 ohms/cm . Short- circuit current Isc and electrical

  10. Trends in vegetation activity and their climatic correlates: China 1982 to 1998

    E-Print Network [OSTI]

    Xiao, Jingfeng

    suggests an increasing carbon stock in forest biomass in China, which supports previous studies basedTrends in vegetation activity and their climatic correlates: China 1982 to 1998 JINGFENG XIAO in vegetation activity and their correlation with climate variability in China between 1982 and 1998. Vegetation

  11. Wet to dry crossover and a flow vortex-lattice in active nematics

    E-Print Network [OSTI]

    Doostmohammadi, Amin; Thampi, Sumesh P; Yeomans, Julia M

    2015-01-01T23:59:59.000Z

    Active systems, from bacterial suspensions to vibrated granular matter, are continuously driven out of equilibrium by local injection of energy from their constituent elements. The energy input leads to exotic behaviour such as collective motion, pattern formation, topological defects and active turbulence, but theories that link the different manifestations of activity across systems and length scales are lacking. Here we unify two different classes of active matter by using friction as a control parameter to interpolate between wet active systems, whose behaviour is dominated by hydrodynamics, and dry active matter where any flow is screened. At the wet-dry crossover, we find a novel lattice of flow vortices interleaved with an ordered network of topological defects which arises from the competition between friction and viscous dissipation. Our results contribute to understanding the physics of matter operating out-of-equilibrium, with its potential in the design of active micro- and nano-machines.

  12. Wet to dry crossover and a flow vortex-lattice in active nematics

    E-Print Network [OSTI]

    Amin Doostmohammadi; Michael Adamer; Sumesh P. Thampi; Julia M. Yeomans

    2015-05-15T23:59:59.000Z

    Active systems, from bacterial suspensions to vibrated granular matter, are continuously driven out of equilibrium by local injection of energy from their constituent elements. The energy input leads to exotic behaviour such as collective motion, pattern formation, topological defects and active turbulence, but theories that link the different manifestations of activity across systems and length scales are lacking. Here we unify two different classes of active matter by using friction as a control parameter to interpolate between wet active systems, whose behaviour is dominated by hydrodynamics, and dry active matter where any flow is screened. At the wet-dry crossover, we find a novel lattice of flow vortices interleaved with an ordered network of topological defects which arises from the competition between friction and viscous dissipation. Our results contribute to understanding the physics of matter operating out-of-equilibrium, with its potential in the design of active micro- and nano-machines.

  13. Inventory of Existing Programs and Activities in the Lower Willamette Subbasin

    E-Print Network [OSTI]

    1 Appendix O Inventory of Existing Programs and Activities in the Lower Willamette Subbasin Within partnerships, inventories, manuals, regulations, and individual projects for the subbasin's land, streams

  14. Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells

    E-Print Network [OSTI]

    Verma, Suman; Tabb, Michelle M; Blumberg, Bruce

    2009-01-01T23:59:59.000Z

    E) SXR activation leads to Nitric Oxide (NO) accumulation.in nitric oxide (NO) levels lead to p53 stabilization and

  15. Locating an active fault zone in Coso geothermal field by analyzing...

    Open Energy Info (EERE)

    from microearthquake data Jump to: navigation, search OpenEI Reference LibraryAdd to library Conference Proceedings: Locating an active fault zone in Coso geothermal field by...

  16. Longest-Serving Active Paper Mill in the Western United States...

    Broader source: Energy.gov (indexed) [DOE]

    MMBtu and 379,000 annually after receiving a DOE energy assessment and implementing steam system improvement recommendations. Longest-Serving Active Paper Mill in the Western...

  17. Discovery of Active Galactic Nuclei in Mid- and Far-Infrared Deep Surveys with ISO

    E-Print Network [OSTI]

    Yoshiaki Taniguchi

    2001-11-01T23:59:59.000Z

    We present a summary on the discovery of active galactic nuclei in mid- and far-infrared deep surveys with use of the Infrared Space Observatory.

  18. Analysis of neutral active particle loss in afterglow in krypton at 2.6 mbar pressure

    SciTech Connect (OSTI)

    Pejovic, Momcilo M.; Karamarkovic, Jugoslav P.; Ristic, Goran S.; Pejovic, Milic M. [Faculty of Electronic Engineering, University of Nis, P.O. Box 73, 18001 Nis (Serbia); Faculty of Civil Engineering and Architecture, University of Nis, A. Medvedeva 14, 18001 Nis (Serbia); Faculty of Electronic Engineering, University of Nis, P.O. Box 73, 18001 Nis (Serbia)

    2008-01-15T23:59:59.000Z

    This paper presents the analysis of the surface recombination and/or de-excitation of neutral active particles in two different volume krypton-filled tubes at pressure of 2.6 mbar with 1 ppm oxygen impurities. The analysis was performed on the basis of secondary electron emission from the cathode induced by positive ions and neutral active particles using the experimental data of electrical breakdown time delay mean value t{sub d} as a function of afterglow period {tau} ('memory curve'). It was shown that the main channel of neutral active particles' loss in afterglow is their recombination and/or de-excitation on the bulb walls. The loss rate increases with the increase of available wall surface per unit of gas volume. It was also shown that in early afterglow (15 ms for the tube with smaller bulb volume and 30 ms for the tube with bigger bulb volume) positive ions are formed in the mutual collisions of neutral active particles, and these ions dominantly influence the secondary electron emission from the cathode. In late afterglow (to 30 s for the tube with smaller bulb volume and to 150 s for the tube with bigger bulb volume) neutral active particles have dominant role in secondary electron emission from the cathode. The probability for this process decreases with the increase of afterglow period as a consequence of the decrease of the concentration of neutral active particles in gas, and this probability is smaller for the tube with smaller bulb volume. The influence of additional electron yield in the electrode gap caused by gamma radiation on breakdown initiation is also analyzed. It is shown that the influence of the neutral active particles in the process of secondary electron emission in the case of gamma radiation is also significant in both early and late afterglow.

  19. Original article Expression and activity of N-myristoyltransferase in lung

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Original article Expression and activity of N-myristoyltransferase in lung inflammation of cattle and inflamed lungs of the cattle are unknown. Therefore, we investigated the expression and activity of NMT in a bovine model of lung inflammation induced with Mannheimia hemolytica and in vitro in neutrophils

  20. Survival and activity of Streptococcus faecalis and Escherichia coli in tropical freshwater

    SciTech Connect (OSTI)

    Muniz, I.; Jimenez, L.; Toranzos, G.A.; Hazen, T.C. [Univ. of Puerto Rico, Rio Piedras (Puerto Rico)

    1988-12-31T23:59:59.000Z

    The survival of Streptococcus facecalis and Escherichia coli was studied in situ in a tropical rain forest watershed using membrane diffusion chambers. Densities were determined by acridine orange direct count and Coulter Counter. Population activity was determined by microautoradiography, cell respiration, and by nucleic acid composition. Densities of S. facecalis and E. coli decreased less than 1 log unit after 105 h as measured by direct count methods. Activity as measured by respiration, acridine orange activity, and microautoradiography indicated that both bacteria remained moderately active during the entire study. After 12 h, E. coli was more active than S. faecalis as measured by nucleic acid composition. E. coli and S. faecalis survived and remained active for more than 5 days. Consequently, both would seem to be unsuitable as indicators of recent fecal contamination in tropical waters.

  1. Origin of the Structures in the C-12(o-16,alpha) Reaction - Dominance of Ne-20-Star and O-16-Star Sequential Alpha-Decay Processes

    E-Print Network [OSTI]

    Murakami, T.; Ungricht, E.; Takahashi, N.; Lui, YW; Mihara, Y.; Neese, R. E.; Takada, E.; Tanner, D. M.; Tribble, Robert E.; Nagatani, K.

    1984-01-01T23:59:59.000Z

    ?(24Mg)=20.2 MeV state. The solid and dashed curves are the theoretical spectra obtatined by the Hauser-Feshbach code EVA (see the text, Sec. V). I oo 0.5- 0.0 50 I I30 20 E?( Mg} MeV l39.4 I36.4 l33.5 IO B. Experimental results Inclusive..., we modified the Monte Carlo code EVA (Ref. 23) which fol- lows the Hauser-Feshbach formalism. The calculation in- cludes the successive evaporation of neutrons, protons, and a particles. The level densities used are from the prescription...

  2. DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats

    SciTech Connect (OSTI)

    Bian, Er-Bao; Huang, Cheng; Ma, Tao-Tao; Tao, Hui; Zhang, Hui; Cheng, Chang; Lv, Xiong-Wen; Li, Jun, E-mail: hunkahmu@126.com

    2012-10-01T23:59:59.000Z

    Hepatic stellate cell (HSC) activation is an essential event during liver fibrogenesis. Phosphatase and tension homolog deleted on chromosome 10 (PTEN), a tumor suppressor, is a negative regulator of this process. PTEN promoter hypermethylation is a major epigenetic silencing mechanism in tumors. The present study aimed to investigate whether PTEN promoter methylation was involved in HSC activation and liver fibrosis. Treatment of activated HSCs with the DNA methylation inhibitor 5-aza-2?-deoxycytidine (5-azadC) decreased aberrant hypermethylation of the PTEN gene promoter and prevented the loss of PTEN expression that occurred during HSC activation. Silencing DNA methyltransferase 1 (DNMT1) gene also decreased the PTEN gene promoter methylation and upregulated the PTEN gene expression in activated HSC-T6 cells. In addition, knockdown of DNMT1 inhibited the activation of both ERK and AKT pathways in HSC-T6 cells. These results suggest that DNMT1-mediated PTEN hypermethylation caused the loss of PTEN expression, followed by the activation of the PI3K/AKT and ERK pathways, resulting in HSC activation. Highlights: ? PTEN methylation status and loss of PTEN expression ? DNMT1 mediated PTEN hypermethylation. ? Hypermethylation of PTEN contributes to the activation of ERK and AKT pathways.

  3. Activation of MAP Kinase (ERK1/2) in human neonatal colonic enteric nervous system

    E-Print Network [OSTI]

    Boyer, Edmond

    Activation of MAP Kinase (ERK1/2) in human neonatal colonic enteric nervous system Authors Caroline was to examine MAP kinase (ERK1/2) activation in the human neonatal colonic enteric nervous system. For this, we investigated by immunocytochemistry the cellular localization of phosphorylated ERK1/2 (P-ERK) in a series

  4. Fluctuations and Rheology in Active Bacterial Suspensions D. T. N. Chen,1

    E-Print Network [OSTI]

    McGaughey, Alan

    the power spectrum of the active stress fluctuations. In some cases, we observe 1= ! p scaling in the noise Active complex fluid systems such as living cells [1,2], assemblies of motors and filaments [3], flocks of birds [4], and vibrated granular media [5] differ from conventional equilibrium media in that some

  5. ANALYSIS OF ELECTRIC CURRENT HELICITY IN ACTIVE REGIONS ON THE BASIS OF VECTOR MAGNETOGRAMS

    E-Print Network [OSTI]

    Yurchyshyn, Vasyl

    can suggest that the build up of large­scale currents in an active region due to small­scale of Sciences, Beijing 100080, China Abstract. The problem of (dc) magnetic field energy build up in the solar seemingly can occur in any active region, the energy build up mechanism must be easy accessible for all

  6. Caspase Activation in Hair Cells of the Mouse Utricle Exposed to Neomycin

    E-Print Network [OSTI]

    Rubel, Edwin

    Caspase Activation in Hair Cells of the Mouse Utricle Exposed to Neomycin Lisa L. Cunningham, Alan exposure results in the apoptotic destruction of auditory and vestibular hair cells. This ototoxic hair, immunohistochemistry, and specific caspase inhibitors to determine which caspases are activated in the hair cells

  7. A retrospective study on changes in residents' physical activities, social 

    E-Print Network [OSTI]

    Zhu, Xuemei; Yu, Chia-Yuan; Lee, Chanam; Lu, Zhipeng; Mann, George

    2014-01-01T23:59:59.000Z

    , walkable communities typically feature? This paper is being submitted for the Active Living Re ? Corresponding author. E-mail addresses: xzhu@arch.tamu.edu (X. Zhu), yu17 clee@arch.tamu.edu (C. Lee), zlu@arch.tamu.edu (Z. Lu), m http://dx.doi.org/10.1016/j...,?, Chia-Yuan Yu b, Chanam Lee b, Zhipen a Department of Architecture, Center for Health Systems & Design, Texas A&M University, 313 b Department of Landscape Architecture and Urban Planning, Center for Health Systems & Dessearch Supplement. 891@neo...

  8. Sign singularity and flares in solar active region NOAA 11158

    E-Print Network [OSTI]

    Sorriso-Valvo, Luca; Kazachenko, Maria D; Krucker, Sam; Primavera, Leonardo; Servidio, Sergio; Vecchio, Antonio; Welsch, Brian T; Fisher, George H; Lepreti, Fabio; Carbone, Vincenzo

    2015-01-01T23:59:59.000Z

    Solar Active Region NOAA 11158 has hosted a number of strong flares, including one X2.2 event. The complexity of current density and current helicity are studied through cancellation analysis of their sign-singular measure, which features power-law scaling. Spectral analysis is also performed, revealing the presence of two separate scaling ranges with different spectral index. The time evolution of parameters is discussed. Sudden changes of the cancellation exponents at the time of large flares, and the presence of correlation with EUV and X-ray flux, suggest that eruption of large flares can be linked to the small scale properties of the current structures.

  9. Measurement of bone mineral content in caged and active cats

    E-Print Network [OSTI]

    Tveter, Diane Ellen

    1988-01-01T23:59:59.000Z

    cat that was scanned three times 33 Table 6. BNC/W values (gm/cm) on a caged cat that was scanned twice 33 LIST OF FIGURES Page Diagram of the vertebral column of cat 18 Illustration of spine (dorsal view) for an active cat . . . . . . . . . 23... radiation, and beam hardening (1, 27, 37). The higher energy of 153Gd photons allows scanning of larger body parts such as the spine and the hip. The beam is produced using a well collimated 153Gd source with two photon energies at 44 keV, and 100 ke...

  10. Correlations between promoter activity and its nucleotide positions in spacing region

    E-Print Network [OSTI]

    Li, Jingwei

    2015-01-01T23:59:59.000Z

    Transcription is one of the essential processes for cells to read genetic information encoded in genes, which is initiated by the binding of RNA polymerase to related promoter. Experiments have found that the nucleotide sequence of promoter has great influence on gene expression strength, or promoter activity. In synthetic biology, one interesting question is how we can synthesize a promoter with given activity, and which positions of promoter sequence are important for determining its activity. In this study, based on recent experimental data, correlations between promoter activity and its sequence positions are analyzed by various methods. Our results show that, except nucleotides in the two highly conserved regions, $-35$ box and $-10$ box, influences of nucleotides in other positions are also not neglectable. For example, modifications of nucleotides around position $-19$ in spacing region may change promoter activity in a large scale. The results of this study might be helpful to our understanding of bio...

  11. Active Bank Switching for Temperature Control of the Register File in a Microprocessor

    E-Print Network [OSTI]

    Pedram, Massoud

    Active Bank Switching for Temperature Control of the Register File in a Microprocessor Kimish Patel, called active bank switching, for temperature control in the register file of a microprocessor to microprocessor performance and a significant component of its cost. Expensive packaging and heat removal

  12. Optimization of Power in the Problems of Active Control of Sound

    E-Print Network [OSTI]

    Optimization of Power in the Problems of Active Control of Sound J. Loncari´c 1 Los Alamos National, i.e., by introducing the additional acoustic sources called controls that generate the appropriate anti-sound. Previously, we have obtained general solutions for active controls in both continuous

  13. Temporal variability of uranium concentrations and 234 activity ratios in the Mississippi river and its tributaries

    E-Print Network [OSTI]

    conservatively under oxic conditions. As a consequence, the uranium concentration of seawater is relativelyTemporal variability of uranium concentrations and 234 U/238 U activity ratios in the Mississippi/238 U activity ratios and total dissolved uranium concentrations in the Lower Mississippi River at New

  14. Update Propagation in Chimera, an Active DOOD Language \\Lambda Ulrike Griefahn Rainer Manthey

    E-Print Network [OSTI]

    Clausen, Michael

    Update Propagation in Chimera, an Active DOOD Language \\Lambda Ulrike Griefahn Rainer Manthey with the propagation of updates in an active DOOD language. The approach proposed is to make use of Chimera triggers for computing induced updates. It will be shown how a subset of Chimera's deductive rules can be compiled

  15. Active Biomonitoring for PCB, PAH and Chlordane Sources in the Anacostia Watershed

    E-Print Network [OSTI]

    District of Columbia, University of the

    1 Active Biomonitoring for PCB, PAH and Chlordane Sources in the Anacostia Watershed Final Report to the DC Water Resources Research Center Dr. Harriette L. Phelps June 1, 2008 ABSTRACT In 2007, active's Anacostia River upper tributaries. The contaminated tributaries included Indian Creek (PAHs), Lower

  16. DAY VERSUS NIGHT ACTIVITY OF REEF FISHES IN A KELP FOREST OFF SANTA BARBARA, CALIFORNIA

    E-Print Network [OSTI]

    DAY VERSUS NIGHT ACTIVITY OF REEF FISHES IN A KELP FOREST OFF SANTA BARBARA, CALIFORNIA ALFRED W. EBELING AND RICHARD N. BRAY! ABSTRACT Vertical distributions and feeding activities of residential kelp-bed fishes were compared between day and night in an area of reef and kelp off Santa Barbara, Calif

  17. Modeling of a Nickel-Hydrogen Cell Phase Reactions in the Nickel Active Material

    E-Print Network [OSTI]

    Modeling of a Nickel-Hydrogen Cell Phase Reactions in the Nickel Active Material B. Wu and R. E of South Carolina, Columbia, South Carolina 29208, USA A nonisothermal model of a nickel-hydrogen cell has been developed with the consideration of multiple phases in the nickel active material. Important

  18. Research Report Age effects on load-dependent brain activations in working

    E-Print Network [OSTI]

    Research Report Age effects on load-dependent brain activations in working memory for novel being scanned with bold fMRI. The stimuli in the DIR task consisted of computer-generated closed-curve to the young participants. Spatial patterns of brain activation that corresponded to load-dependent (stimulus

  19. Excitation and Active Control of Propagating Surface Plasmon Polaritons in Graphene

    E-Print Network [OSTI]

    Kono, Junichiro

    Excitation and Active Control of Propagating Surface Plasmon Polaritons in Graphene Weilu Gao, Gang polaritons propagating through monolayer graphene using a silicon diffractive grating. The normal and actively control plasmonic waves in graphene and is thus an important building block of graphene plasmonic

  20. Leveraging temporal, contextual and ordering constraints for recognizing complex activities in video

    E-Print Network [OSTI]

    Jaffe, Jules

    in video Benjamin Laxton Jongwoo Lim David Kriegman blaxton@cs.ucsd.edu jlim@honda-ri.com kriegman. Abstract We present a scalable approach to recognizing and de- scribing complex activities in video new actions. We show results for our approach on real video sequences containing complex activities. 1

  1. Contribution of simulation in the product-driven systems production activity control

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    control consists in improving existing manufacturing production planning and control systems. We graduallyContribution of simulation in the product-driven systems production activity control Olivier CARDIN the emergence of product driven production activity control concept, the development of RFID technologies had

  2. Illegal Logging and Illegal Activities in the Forestry Sector: Overview and Possible Issues

    E-Print Network [OSTI]

    Illegal Logging and Illegal Activities in the Forestry Sector: Overview and Possible Issues Product Markets and Marketing identified the issue of illegal logging and illegal activities these countries' boundaries and provides examples in developed nations. The pernicious effects of illegal logging

  3. Potential effects of environmental contaminants on P450 aromatase activity and DNA damage in swallows

    E-Print Network [OSTI]

    Mora, Miguel A.

    Potential effects of environmental contaminants on P450 aromatase activity and DNA damage, to evaluate the potential effects of environmental contaminants on P450 aromatase activity in brain and gonads and DNA damage in blood cells. The tritiated water-release aromatase assay was used to measure aromatase

  4. Ultraviolet Diagnostics for the Emission Line Gas in Active Galaxies

    E-Print Network [OSTI]

    M. G. Allen; M. A. Dopita; Z. I. Tsvetanov

    1998-01-06T23:59:59.000Z

    Optical diagnostic diagrams are frequently ambiguous as a test of the photoionization or fast shock models of the narrow line regions of active galaxies. Here, we present a set of UV line ratio diagrams which can discriminate between pure shock and photoionization modes of excitation, and to some extent, also discriminate shocks with ionized precursors from photoionization. These diagrams use relatively bright emission lines and reddening insensitive ratios and provide a practical observational test for separating the excitation mechanisms of the narrow line regions of active galaxies. The most useful diagrams are those involving the various ionization stages of Carbon, [OIII]5007/H-beta vs. CIV 1550/ HeII 1640 and the purely UV ratio pair CII] 2326 / CIII] 1909 vs. CIV 1550 / CIII]909. Temperature sensitive FUV lines CIII 977 and NIII 991 also provide good discriminants. The models are compared to observations of nearby AGN, and also to high redshift objects where the UV lines are shifted into the optical.

  5. DISTINCT PATTERNS OF NITRATE REDUCTASE ACTIVITY IN BROWN ALGAE: LIGHT AND AMMONIUM SENSITIVITY IN LAMINARIA DIGITATA IS ABSENT IN

    E-Print Network [OSTI]

    Berges, John A.

    DISTINCT PATTERNS OF NITRATE REDUCTASE ACTIVITY IN BROWN ALGAE: LIGHT AND AMMONIUM SENSITIVITY and lowest in summer. This is the first report of NR activity in any alga that is not strongly regulated the regulation of NR by light that has been observed in other algae and higher plants. Key index words: ammonium

  6. LANL | Physics | Active Interrogation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Physics Division activities in standoff active-interrogation for detecting terrorist nuclear devices, 2011 Detonation of a terrorist nuclear device in a major city would have...

  7. Low dose cadmium poisoning results in sustained ERK phosphorylation and caspase activation

    SciTech Connect (OSTI)

    Martin, Patrick [Transcriptional Regulation and Differentiation, CNRS UMR 6548, Nice University, Parc Valrose, 06108 Nice cedex 2 (France)]. E-mail: pmartin@unice.fr; Poggi, Marie Christine [Transcriptional Regulation and Differentiation, CNRS UMR 6548, Nice University, Parc Valrose, 06108 Nice cedex 2 (France)]. E-mail: poggi@unice.fr; Chambard, Jean Claude [Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre Antoine Lacassagne, 33 Ave. de Valombrose, 06189 Nice (France)]. E-mail: chambard@unice.fr; Boulukos, Kim E. [Transcriptional Regulation and Differentiation, CNRS UMR 6548, Nice University, Parc Valrose, 06108 Nice cedex 2 (France)]. E-mail: boulukos@unice.fr; Pognonec, Philippe [Transcriptional Regulation and Differentiation, CNRS UMR 6548, Nice University, Parc Valrose, 06108 Nice cedex 2 (France)]. E-mail: pognonec@unice.fr

    2006-11-24T23:59:59.000Z

    Cadmium poisoning has been known to result in a wide variety of cellular responses, including oxidative stress and kinase activation. It has been reported that ERK is activated following acute cadmium exposure, and this response is commonly seen as a classical ERK survival mechanism. Here, we analyzed different cell types for their responses to low concentrations of cadmium poisoning. We found that there is an association between cell susceptibility to cadmium toxicity and ERK activation. This activation is atypical, since it consists of a sustained ERK phosphorylation, that lasts up to 6 days post stimulation. This activation is associated with the appearance of cleaved caspases 8 and 3, processed PARP, and irreversible damage. Pharmacological inhibition of ERK phosphorylation results in the ability of cells to resist cadmium poisoning. Our data indicate that low cadmium concentrations result in an unconventional ERK sustained phosphorylation, which in turn leads to death signaling.

  8. Acoustic Modes in Combustors with Complex Impedances and Multidimensional Active Flames

    E-Print Network [OSTI]

    Nicoud, Franck

    Acoustic Modes in Combustors with Complex Impedances and Multidimensional Active Flames F. Nicoud for computing the thermoacoustic modes in combustors. In the case of a nonisothermal reacting medium, the wave

  9. Optogenetic astrocyte activation modulates response selectivity of visual cortex neurons in vivo

    E-Print Network [OSTI]

    Perea, Gertrudis

    Astrocytes play important roles in synaptic transmission and plasticity. Despite in vitro evidence, their causal contribution to cortical network activity and sensory information processing in vivo remains unresolved. Here ...

  10. Creation of cavitation activity in a microfluidic device through acoustically driven capillary waves

    E-Print Network [OSTI]

    Ohl, Claus-Dieter

    Creation of cavitation activity in a microfluidic device through acoustically driven capillary acoustic cavitation generated by ultrasonic vibrations in polydimethylsiloxane (PDMS) based microfluidic in the microfluidic channels. Also, it is observed that nuclei leading to intense inertial cavitation are generated

  11. GRP94/gp96 Elicits ERK Activation in Murine Macrophages A ROLE FOR ENDOTOXIN CONTAMINATION IN NF-B ACTIVATION AND NITRIC OXIDE PRODUCTION*

    E-Print Network [OSTI]

    Nicchitta, Chris

    GRP94/gp96 Elicits ERK Activation in Murine Macrophages A ROLE FOR ENDOTOXIN CONTAMINATION IN NF- B signaling and ni- tric oxide production, as well as the MAP kinase p38, JNK, and ERK signaling cascades a marked increase in ERK phosphorylation at protein concentrations as low as 2 g/ml. These results

  12. Propagation of guided Lamb waves in bonded specimens using piezoelectric wafer active sensors

    E-Print Network [OSTI]

    Giurgiutiu, Victor

    Propagation of guided Lamb waves in bonded specimens using piezoelectric wafer active sensors and principles used for generation and propagation of ultrasonic guided waves (Lamb waves) using piezoelectric wafer active sensors (PWAS). Keywords: Ultrasonic, Lamb waves, Damage detection, NDE, Wave propagation

  13. Contribution of Identified Active Faults to Near Fault Seismic Hazard in the Flinders Ranges

    E-Print Network [OSTI]

    Sandiford, Mike

    Somerville1 , Peggy Quijada1 , Hong Kie Thio1 , Mike Sandiford2 and Mark Quigley2 1. URS Corporation estimates of fault slip rate from Quigley et al. (2006) to quantify the seismic activity rate on the faults of these models was used in conjunction with the active fault model. Quigley et al. (2006) identified a system

  14. RELIABILITY ANALYSIS IN A FAULT TOLERANT CONTROL STRATEGY DEDICATED TO ACTIVE POWER FILTER

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    RELIABILITY ANALYSIS IN A FAULT TOLERANT CONTROL STRATEGY DEDICATED TO ACTIVE POWER FILTER P. WEBER reliability indicate the optimal structure. Keywords: Fault Tolerant Control, System Reliability, Active power control and nuclear power plant operation (Zhang and Jiang, 2003). Various studies on FTC are based

  15. Drive actuation in active control of centrifugal compressors Jan Tommy Gravdahl and Olav Egeland

    E-Print Network [OSTI]

    Gravdahl, Jan Tommy

    Drive actuation in active control of centrifugal compressors Jan Tommy Gravdahl and Olav Egeland-1375 Billingstad NORWAY CompressorShaft Electric drive Active surge control law Shaft speed Compressor compressor surge has been avoided using surge avoidance schemes that use various techniques to keep

  16. Two-phase refrigerant flow instability analysis and active control in transient electronics cooling systems

    E-Print Network [OSTI]

    Peles, Yoav

    Two-phase refrigerant flow instability analysis and active control in transient electronics cooling Pressure-drop oscillation Refrigeration system Two-phase cooling Active control Transient heat load a b s t r a c t Two-loop refrigeration systems are being explored for two-phase cooling of ultra high power

  17. Active Slip Band Separation and the Energetics of Slip in Single Crystals

    E-Print Network [OSTI]

    Active Slip Band Separation and the Energetics of Slip in Single Crystals Abstract This research supports recent efforts to provide an energetic ap- proach the formulation of new measures of the active slip-band separation and of the number of lattice cells

  18. Flexible Sensor Array Wraps Beating Hearts to Map Cardiac Activity in Real Time

    E-Print Network [OSTI]

    Rogers, John A.

    Flexible Sensor Array Wraps Beating Hearts to Map Cardiac Activity in Real Time By Jeremy Hsu Flexible Silicon Sensors Put this sensor on your heart and tell me it's all over University of Illinois Getting a cardiac map of the electrical activity coursing through a live, beating heart has proven

  19. Structure-Activity Correlations in a Nickel-Borate Oxygen Evolution D. Kwabena Bediako,

    E-Print Network [OSTI]

    Structure-Activity Correlations in a Nickel-Borate Oxygen Evolution Catalyst D. Kwabena Bediako of the electrodeposited films, is accompanied by structure and oxidation state changes. Coulometric measurements correlated with X-ray absorption near- edge structure spectra of the active catalyst show that the nickel

  20. Assessment of dermal exposure to benzene and toluene in shoe manufacturing by activated carbon cloth patches

    E-Print Network [OSTI]

    California at Berkeley, University of

    Assessment of dermal exposure to benzene and toluene in shoe manufacturing by activated carbon activated carbon cloth (ACC) patches to study the probability and extent of dermal exposure to benzene for the contribution from the air through passive absorption of benzene and toluene on the ACC patches. Systemic

  1. Supervised Classification of Activities of Daily Living in Health Smart Homes using SVM

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Supervised Classification of Activities of Daily Living in Health Smart Homes using SVM Anthony) on real data. Index Terms--Support vector machines, Activities of Daily Living, Health Smart Homes, Sensor smart homes to achieve this goal [1]. Several solutions are stud- ied by laboratories and companies

  2. Flexibility in Anaerobic Metabolism as Revealed in a Mutant of Chlamydomonas reinhardtii Lacking Hydrogenase Activity

    E-Print Network [OSTI]

    fermentation products formate, acetate, ethanol, CO2 and molecular hydrogen (H2,) in what is classified reinhardtii has a network of fermentation pathways that become active when cells acclimate to anoxia contribute to NAD(P)H reoxidation, and continued glycolysis and fermentation in the absence of O2

  3. Silvicultural Activities in Relation to Water Quality in Texas: An Assesment of Potential Problems and Solutions

    E-Print Network [OSTI]

    Blackburn, W. H.; Hickman, C. A.; deSteiguer, J. E.; Jackson, B. D.; Blume, T. A.; DeHaven, M. G.

    1978-02-01T23:59:59.000Z

    TR- 97 1978 Silvicultural Activities in Relation to Water Quality in Texas: An Assessment of Potential Problems and Solutions W.H. Blackburn C.A. Hickman J.E. deSteiguer B.D. Jackson T.A. Blume M.G. De...Haven Texas Water Resources Institute Texas A&M University ...

  4. NIOSH -Nanotechnology Research Center Active in the lab and in the field

    E-Print Network [OSTI]

    Farritor, Shane

    NIOSH - Nanotechnology Research Center Active in the lab and in the field Laura Hodson, MSPH, CIH Kenneth F. Martinez, MSEE, CIH Charles Geraci, PhD, CIH Nanotechnology Research Center Education and should not be construed to represent any agency determination or policy. #12;Nanotechnology

  5. Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease

    SciTech Connect (OSTI)

    Wu, Weibin [Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032 (China) [Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032 (China); Institutes of Biomedical Science, Fudan University, Shanghai 200032 (China); Zhu, Bo; Peng, Xiaomin [Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032 (China)] [Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032 (China); Zhou, Meiling, E-mail: meilingzhou2012@gmail.com [Department of Radiology, Zhongshan Hospital of Fudan University and Shanghai Institute of Medical Imaging, Shanghai 200032 (China)] [Department of Radiology, Zhongshan Hospital of Fudan University and Shanghai Institute of Medical Imaging, Shanghai 200032 (China); Jia, Dongwei, E-mail: jiadongwei@fudan.edu.cn [Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032 (China)] [Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032 (China); Gu, Jianxin [Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032 (China) [Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032 (China); Institutes of Biomedical Science, Fudan University, Shanghai 200032 (China)

    2014-01-03T23:59:59.000Z

    Highlights: •FXR activity was impaired by chronic ethanol ingestion in a murine model of ALD. •Activation of FXR attenuated alcohol-induced liver injury and steatosis. •Activation of FXR attenuated cholestasis and oxidative stress in mouse liver. -- Abstract: Alcoholic liver disease (ALD) is a common cause of advanced liver disease, and considered as a major risk factor of morbidity and mortality worldwide. Hepatic cholestasis is a pathophysiological feature observed in all stages of ALD. The farnesoid X receptor (FXR) is a member of the nuclear hormone receptor superfamily, and plays an essential role in the regulation of bile acid, lipid and glucose homeostasis. However, the role of FXR in the pathogenesis and progression of ALD remains largely unknown. Mice were fed Lieber-DeCarli ethanol diet or an isocaloric control diet. We used a specific agonist of FXR WAY-362450 to study the effect of pharmacological activation of FXR in alcoholic liver disease. In this study, we demonstrated that FXR activity was impaired by chronic ethanol ingestion in a murine model of ALD. Activation of FXR by specific agonist WAY-362450 protected mice from the development of ALD. We also found that WAY-362450 treatment rescued FXR activity, suppressed ethanol-induced Cyp2e1 up-regulation and attenuated oxidative stress in liver. Our results highlight a key role of FXR in the modulation of ALD development, and propose specific FXR agonists for the treatment of ALD patients.

  6. Overview of ASTM standard activities in support of advanced structural ceramics development

    SciTech Connect (OSTI)

    Brinkman, C.R. [Oak Ridge National Lab., TN (United States); Quinn, G.D. [NIST, Gaithersburg, MD (United States); McClung, R.W.

    1995-07-01T23:59:59.000Z

    An overview is presented of the activities of ASTM Committee C-28 on Advanced Ceramics. This activity originated in 1986 when it became apparent that advanced ceramics were being considered for extensive use in applications such as advanced heat engines, heat exchangers, combustors, etc. in aerospace and energy conservation activities. These applications require optimum material behavior with physical and mechanical property reproducibility, component reliability, and well defined methods of data treatment and material analysis for both monolithic and composite ceramic materials. As new materials are introduced into the market place, these issues are best dealt with via standard methods. Therefore, a progress report is given describing activities of the five standard writing subcommittees who support the ASTM Committee C-28 effort. Accomplishments to date are given, as well as likely future activities, including a brief summary of joint cooperative efforts with international standard formulating organizations.

  7. Identifying Activity

    E-Print Network [OSTI]

    Lewis, Adrian S

    2009-01-01T23:59:59.000Z

    Identification of active constraints in constrained optimization is of interest from both practical and theoretical viewpoints, as it holds the promise of reducing an inequality-constrained problem to an equality-constrained problem, in a neighborhood of a solution. We study this issue in the more general setting of composite nonsmooth minimization, in which the objective is a composition of a smooth vector function c with a lower semicontinuous function h, typically nonsmooth but structured. In this setting, the graph of the generalized gradient of h can often be decomposed into a union (nondisjoint) of simpler subsets. "Identification" amounts to deciding which subsets of the graph are "active" in the criticality conditions at a given solution. We give conditions under which any convergent sequence of approximate critical points finitely identifies the activity. Prominent among these properties is a condition akin to the Mangasarian-Fromovitz constraint qualification, which ensures boundedness of the set of...

  8. In vitro anticancer activity, toxicity and structure-activity relationships of phyllostictine A, a natural oxazatricycloalkenone produced by the fungus Phyllosticta cirsii

    SciTech Connect (OSTI)

    Le Calve, Benjamin [Laboratoire de Toxicologie, Faculte de Pharmacie de Pharmacie, Universite Libre de Bruxelles (ULB), Brussels (Belgium); Lallemand, Benjamin [Laboratoire de Chimie Analytique, Toxicologie et de Chimie Physique Appliquee, Faculte de Pharmacie de Pharmacie, Universite Libre de Bruxelles (ULB), Brussels (Belgium); Perrone, Carmen [Dipartimento di Scienze, del Suolo, della Pianta, dell'Ambiente e delle Produzioni Animali, Universita di Napoli Federico II, Portici (Italy); Lenglet, Gaelle; Depauw, Sabine [INSERM U-837, Jean-Pierre Aubert Research Center (JPARC), Team Molecular and Cellular Targeting for Cancer Treatment, Institut pour la Recherche sur le Cancer de Lille, Lille (France); Van Goietsenoven, Gwendoline; Bury, Marina [Laboratoire de Toxicologie, Faculte de Pharmacie de Pharmacie, Universite Libre de Bruxelles (ULB), Brussels (Belgium); Vurro, Maurizio [Istituto di Scienze delle Produzioni Alimentari, CNR, Bari (Italy); Herphelin, Francoise [Cell and Tissue Laboratory, URPHYM, University of Namur (FUNDP), Namur (Belgium); Andolfi, Anna [Dipartimento di Scienze, del Suolo, della Pianta, dell'Ambiente e delle Produzioni Animali, Universita di Napoli Federico II, Portici (Italy); Zonno, Maria Chiara [Istituto di Scienze delle Produzioni Alimentari, CNR, Bari (Italy); Mathieu, Veronique [Laboratoire de Toxicologie, Faculte de Pharmacie de Pharmacie, Universite Libre de Bruxelles (ULB), Brussels (Belgium); Dufrasne, Francois [Laboratoire de Chimie Pharmaceutique Organique, Faculte de Pharmacie de Pharmacie, Universite Libre de Bruxelles (ULB), Brussels (Belgium); Van Antwerpen, Pierre [Laboratoire de Chimie Pharmaceutique Organique, Faculte de Pharmacie de Pharmacie, Universite Libre de Bruxelles (ULB), Brussels (Belgium); Plate-Forme Analytique, Faculte de Pharmacie de Pharmacie, Universite Libre de Bruxelles (ULB), Brussels (Belgium); Poumay, Yves [Cell and Tissue Laboratory, URPHYM, University of Namur (FUNDP), Namur (Belgium)

    2011-07-01T23:59:59.000Z

    The in vitro anticancer activity and toxicity of phyllostictine A, a novel oxazatricycloalkenone recently isolated from a plant-pathogenic fungus (Phyllosticta cirsii) was characterized in six normal and five cancer cell lines. Phyllostictine A displays in vitro growth-inhibitory activity both in normal and cancer cells without actual bioselectivity, while proliferating cells appear significantly more sensitive to phyllostictine A than non-proliferating ones. The main mechanism of action by which phyllostictine displays cytotoxic effects in cancer cells does not seem to relate to a direct activation of apoptosis. In the same manner, phyllostictine A seems not to bind or bond with DNA as part of its mechanism of action. In contrast, phyllostictine A strongly reacts with GSH, which is a bionucleophile. The experimental data from the present study are in favor of a bonding process between GSH and phyllostictine A to form a complex though Michael attack at C=C bond at the acrylamide-like system. Considering the data obtained, two new hemisynthesized phyllostictine A derivatives together with three other natural phyllostictines (B, C and D) were also tested in vitro in five cancer cell lines. Compared to phyllostictine A, the two derivatives displayed a higher, phyllostictines B and D a lower, and phyllostictine C an almost equal, growth-inhibitory activity, respectively. These results led us to propose preliminary conclusions in terms of the structure-activity relationship (SAR) analyses for the anticancer activity of phyllostictine A and its related compounds, at least in vitro.

  9. Activities of ?-ray emitting isotopes in rainwater from Greater Sudbury, Canada following the Fukushima incident

    E-Print Network [OSTI]

    B. T. Cleveland; F. A. Duncan; I. T. Lawson; N. J. T. Smith; E. Vazquez-Jauregui

    2012-02-29T23:59:59.000Z

    We report the activity measured in rainwater samples collected in the Greater Sudbury area of eastern Canada on 3, 16, 20, and 26 April 2011. The samples were gamma-ray counted in a germanium detector and the isotopes 131I and 137Cs, produced by the fission of 235U, and 134Cs, produced by neutron capture on 133Cs, were observed at elevated levels compared to a reference sample of ice-water. These elevated activities are ascribed to the accident at the Fukushima Dai-ichi nuclear reactor complex in Japan that followed the 11 March earthquake and tsunami. The activity levels observed at no time presented health concerns.

  10. Activity recognition with end-user sensor installation in the home

    E-Print Network [OSTI]

    Rockinson, Randy Joseph

    2008-01-01T23:59:59.000Z

    In this work, a system for recognizing activities in the home setting that uses a set of small and simple state-change sensors, machine learning algorithms, and electronic experience sampling is introduced. The sensors are ...

  11. Identification of Highly Active Fe Sites in (Ni,Fe)OOH for Electrocata...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    enhanced OER activity in Fe-doped -NiOOH, in which Fe sites have near-optimum binding energies for OER intermediates. The conversion of solar energy and water to hydrogen is a...

  12. Neurobiology of Aging xxx (2006) xxxxxx Age-related changes in brain activation during

    E-Print Network [OSTI]

    2006-01-01T23:59:59.000Z

    Neurobiology of Aging xxx (2006) xxx­xxx Age-related changes in brain activation during a delayed. / Neurobiology of Aging xxx (2006) xxx­xxx impairment in several different memory variables [78], including WM [9

  13. Comparative aspects of cholesterol metabolism and lecithin:cholesterol acyltransferase activity in dogs and cats 

    E-Print Network [OSTI]

    Angell, Rebecca Joyce

    2009-05-15T23:59:59.000Z

    Little research has focused on the relationship between lecithin:cholesterol acyltransferase (LCAT) activity and cholesterol metabolism in dogs and cats. To study weight loss and cholesterol metabolism in dogs, four experimental weight-loss diets...

  14. Alterations in canine plasma lipoproteins and lecithin: cholesterol acyltransferase activities during fish oil supplementation 

    E-Print Network [OSTI]

    McAlister, Kristina Gambrell

    1994-01-01T23:59:59.000Z

    In an effort to better understand lipid metabolism in an atherogenic resistant species, effects of n-3 fatty acid rich fish oil on canine lipoproteins and lecithin:cholesterol acyltransferase (LCAT) activities were investigated. Adult, mixed...

  15. SciP : a novel inhibitor of CtrA transcriptional activity in Caulobacter crescentus

    E-Print Network [OSTI]

    Gora, Kasia G. (Kasia Gabriela)

    2011-01-01T23:59:59.000Z

    Cells must sense changes in their environment and respond appropriately in order to survive. A common survival strategy is for cells to translate an environmental signal into the activity of a transcription factor they ...

  16. Graphical Models for Wide-Area Activity Analysis in Continuous Videos

    E-Print Network [OSTI]

    Nayak, Nandita Miyar

    2014-01-01T23:59:59.000Z

    2 Multi-person Activity Recognition in Wide-area Videos 2.1Context Modeling in Continuous Videos Using Graphical Modelsmethod. Given a continuous video with computed tracklets, a

  17. Children Of The Sleeping Giant: Social Activism Among Latino Youth In The United States.

    E-Print Network [OSTI]

    Garcia, Edmundo

    2013-10-07T23:59:59.000Z

    of power. The present thesis examines the activism of Latino/a youth in Southern California against House of Representatives Bill 4437, “The Border Protection, Anti-Terrorism and Illegal Immigration Control Act,” that took place in 2006. During...

  18. Disease Mutations in Rab7 Result in Unregulated Nucleotide Exchange and Inappropriate Activation

    SciTech Connect (OSTI)

    B McCray; E Skordalakes; J Taylor

    2011-12-31T23:59:59.000Z

    Rab GTPases are molecular switches that orchestrate vesicular trafficking, maturation and fusion by cycling between an active, GTP-bound form, and an inactive, GDP-bound form. The activity cycle is coupled to GTP hydrolysis and is tightly controlled by regulatory proteins. Missense mutations of the GTPase Rab7 cause a dominantly inherited axonal degeneration known as Charcot-Marie-Tooth type 2B through an unknown mechanism. We present the 2.8 A crystal structure of GTP-bound L129F mutant Rab7 which reveals normal conformations of the effector binding regions and catalytic site, but an alteration to the nucleotide binding pocket that is predicted to alter GTP binding. Through extensive biochemical analysis, we demonstrate that disease-associated mutations in Rab7 do not lead to an intrinsic GTPase defect, but permit unregulated nucleotide exchange leading to both excessive activation and hydrolysis-independent inactivation. Consistent with augmented activity, mutant Rab7 shows significantly enhanced interaction with a subset of effector proteins. In addition, dynamic imaging demonstrates that mutant Rab7 is abnormally retained on target membranes. However, we show that the increased activation of mutant Rab7 is counterbalanced by unregulated, GTP hydrolysis-independent membrane cycling. Notably, disease mutations are able to rescue the membrane cycling of a GTPase-deficient mutant. Thus, we demonstrate that disease mutations uncouple Rab7 from the spatial and temporal control normally imposed by regulatory proteins and cause disease not by a gain of novel toxic function, but by misregulation of native Rab7 activity.

  19. Activity Based Costing

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1997-03-28T23:59:59.000Z

    Activity Based Costing (ABC) is method for developing cost estimates in which the project is subdivided into discrete, quantifiable activities or a work unit. This chapter outlines the Activity Based Costing method and discusses applicable uses of ABC.

  20. Facilitation of polymer looping and giant polymer diffusivity in crowded solutions of active particles

    E-Print Network [OSTI]

    Shin, J; Kim, W K; Metzler, R

    2015-01-01T23:59:59.000Z

    We study the dynamics of polymer chains in a bath of self-propelled particles (SPP) by extensive Langevin dynamics simulations in a two dimensional system. Specifically, we analyse the polymer looping properties versus the SPP activity and investigate how the presence of the active particles alters the chain conformational statistics. We find that SPPs tend to extend flexible polymer chains while they rather compactify stiffer semiflexible polymers, in agreement with previous results. Here we show that larger activities of SPPs yield a higher effective temperature of the bath and thus facilitate looping kinetics of a passive polymer chain. We explicitly compute the looping probability and looping time in a wide range of the model parameters. We also analyse the motion of a monomeric tracer particle and the polymer's centre of mass in the presence of the active particles in terms of the time averaged mean squared displacement, revealing a giant diffusivity enhancement for the polymer chain via SPP pooling. Our...

  1. In vivo metabolic activity of hamster suprachiasmatic nuclei: use of anesthesia

    SciTech Connect (OSTI)

    Schwartz, W.J.

    1987-02-01T23:59:59.000Z

    In vivo glucose utilization was measured in the suprachiasmatic nuclei (SCN) of Golden hamsters using the /sup 14/C-labeled deoxyglucose technique. A circadian rhythm of SCN metabolic activity could be measured in this species, but only during pentobarbital sodium anesthesia when the surrounding background activity of adjacent hypothalamus was suppressed. Both the SCN's metabolic oscillation and its time-keeping ability are resistant to general anesthesia.

  2. Privatization and regulatory oversight of commercial wildlife control activities in the United States

    E-Print Network [OSTI]

    Lindsey, Kieran J.

    2009-05-15T23:59:59.000Z

    and Regulatory Oversight of Commercial Wildlife Control Activities in the United States. (August 2007) Kieran J. Lindsey, B.S., Texas A&M University; M.S., Texas A&M University Chair of Advisory Commite: Dr. Clark E. Adams Urbanization decreases... PRIVATIZATION AND REGULATORY OVERSIGHT OF COMERCIAL WILDLIFE CONTROL ACTIVITIES IN THE UNITED STATES A Disertation by KIERAN J. LINDSEY Submited to the Ofice of Graduate Studies of Texas A&M University in partial...

  3. The effect of temperature and homogenization pressure on enzymatic activity in cheese whey 

    E-Print Network [OSTI]

    Del Carmen, Maria Yanina

    1995-01-01T23:59:59.000Z

    THE EFFECT OF TEMPERATURE AND HOMOGENIZATION PRESSURE ON ENZYMATIC ACTIVITY IN CHEESE WHEY A Thesis by MARIA YANINA DEL CAWvKN Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirement... for the degree of MASTER OF SCIENCE August 1995 Major Subject; Food Science and Technology THE EFFECT OF TEMPERATURE AND HOMOGENIZATION PRESSURE ON ENZYMATIC ACTIVITY IN CHEESE WHEY A Thesis by MARIA YANINA DEL CARMEN Submitted to the Office of Graduate...

  4. The effect of temperature and homogenization pressure on enzymatic activity in cheese whey

    E-Print Network [OSTI]

    Del Carmen, Maria Yanina

    1995-01-01T23:59:59.000Z

    THE EFFECT OF TEMPERATURE AND HOMOGENIZATION PRESSURE ON ENZYMATIC ACTIVITY IN CHEESE WHEY A Thesis by MARIA YANINA DEL CAWvKN Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirement... for the degree of MASTER OF SCIENCE August 1995 Major Subject; Food Science and Technology THE EFFECT OF TEMPERATURE AND HOMOGENIZATION PRESSURE ON ENZYMATIC ACTIVITY IN CHEESE WHEY A Thesis by MARIA YANINA DEL CARMEN Submitted to the Office of Graduate...

  5. Developmental toxicity and structure-activity relationships of ochratoxin A and related compounds in Hydra attenuata

    E-Print Network [OSTI]

    Taylor, Monica Ann

    1988-01-01T23:59:59.000Z

    DEVELOPMENTAL TOXICITY AND STRUCTURE-ACTIVITY RELATIONSHIPS OF OCHRATOXIN A AND RELATED COMPOUNDS IN HYDRA ATTENUATA A Thesis by MONICA ANN TAYLOR Submitted to the Office of Graduate Studies of Texas ARM University in Partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE December 1988 Major Subject: Food Science and Technology DEVELOPMENTAL TOXICITY AND STRUCTURE-ACTIVITY RELATIONSHIPS OF OCHRATOXIN A AND RELATED COMPOUNDS IN ~HY R ATTENUATA A Thesis by MONICA ANN TAYLOR...

  6. Developmental toxicity and structure-activity relationships of ochratoxin A and related compounds in Hydra attenuata 

    E-Print Network [OSTI]

    Taylor, Monica Ann

    1988-01-01T23:59:59.000Z

    DEVELOPMENTAL TOXICITY AND STRUCTURE-ACTIVITY RELATIONSHIPS OF OCHRATOXIN A AND RELATED COMPOUNDS IN HYDRA ATTENUATA A Thesis by MONICA ANN TAYLOR Submitted to the Office of Graduate Studies of Texas ARM University in Partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE December 1988 Major Subject: Food Science and Technology DEVELOPMENTAL TOXICITY AND STRUCTURE-ACTIVITY RELATIONSHIPS OF OCHRATOXIN A AND RELATED COMPOUNDS IN ~HY R ATTENUATA A Thesis by MONICA ANN TAYLOR...

  7. The induction of breeding activity in lactating ewes during anestrus by the use of hormones 

    E-Print Network [OSTI]

    Ahmed, Shams Uddin

    1963-01-01T23:59:59.000Z

    THE INDUCTION OF BREEDING ACTIVITY IN LACTATING EWES DURING ANESTRUScBY THE USE OF HORMONES A Thesis By Shams Uddin Ahmed Submitted to the Graduate School of the Agricultural and Mechanical College of Texas in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE January, 1963 Major Subject: Physiology of Reproduction 11 THE INDUCTION OF BREEDING ACTIVITY IN LACTATING EWES DURING ANESTRUS BY THE USE OF HORMONES A Thesis By Shams Uddin Ahmed Approved as to style...

  8. Conformational Lability in Serine Protease Active Sites: Structures of Hepatocyte Growth Factor Activator (HGFA) Alone and with the Inhibitory Domain from HGFA Inhibitor-1B

    SciTech Connect (OSTI)

    Shia, Steven; Stamos, Jennifer; Kirchhofer, Daniel; Fan, Bin; Wu, Judy; Corpuz, Raquel T.; Santell, Lydia; Lazarus, Robert A.; Eigenbrot, Charles (Genentech)

    2010-07-20T23:59:59.000Z

    Hepatocyte growth factor activator (HGFA) is a serine protease that converts hepatocyte growth factor (HGF) into its active form. When activated HGF binds its cognate receptor Met, cellular signals lead to cell growth, differentiation, and migration, activities which promote tissue regeneration in liver, kidney and skin. Intervention in the conversion of HGF to its active form has the potential to provide therapeutic benefit where HGF/Met activity is associated with tumorigenesis. To help identify ways to moderate HGF/Met effects, we have determined the molecular structure of the protease domain of HGFA. The structure we determined, at 2.7 {angstrom} resolution, with no pseudo-substrate or inhibitor bound is characterized by an unconventional conformation of key residues in the enzyme active site. In order to find whether this apparently non-enzymatically competent arrangement would persist in the presence of a strongly-interacting inhibitor, we also have determined, at 2.6 {angstrom} resolution, the X-ray structure of HGFA complexed with the first Kunitz domain (KD1) from the physiological inhibitor hepatocyte growth factor activator inhibitor 1B (HAI-1B). In this complex we observe a rearranged substrate binding cleft that closely mirrors the cleft of other serine proteases, suggesting an extreme conformational dynamism. We also characterize the inhibition of 16 serine proteases by KD1, finding that the previously reported enzyme specificity of the intact extracellular region of HAI-1B resides in KD1 alone. We find that HGFA, matriptase, hepsin, plasma kallikrein and trypsin are potently inhibited, and use the complex structure to rationalize the structural basis of these results.

  9. Cadence, power, and muscle activation in cycle ergometry

    E-Print Network [OSTI]

    on the perimeter of the flywheel) in cycle ergometry is similar in many ways to the relationship between force

  10. Reproducible cavitation activity in water-particle suspensions Bram M. Borkent, Manish Arora, and Claus-Dieter Ohla

    E-Print Network [OSTI]

    Ohl, Claus-Dieter

    Reproducible cavitation activity in water-particle suspensions Bram M. Borkent, Manish Arora January 2007 The study of cavitation inception in liquids rarely yields reproducible data, unless special technique is demonstrated which allows repeatable measurements of cavitation activity in liquid

  11. The Role of Organic Capping Layers of Platinum Nanoparticles in Catalytic Activity of CO Oxidation

    SciTech Connect (OSTI)

    Park, Jeong Y.; Aliaga, Cesar; Renzas, J. Russell; Lee, Hyunjoo; Somorjai, Gabor A.

    2008-12-17T23:59:59.000Z

    We report the catalytic activity of colloid platinum nanoparticles synthesized with different organic capping layers. On the molecular scale, the porous organic layers have open spaces that permit the reactant and product molecules to reach the metal surface. We carried out CO oxidation on several platinum nanoparticle systems capped with various organic molecules to investigate the role of the capping agent on catalytic activity. Platinum colloid nanoparticles with four types of capping layer have been used: TTAB (Tetradecyltrimethylammonium Bromide), HDA (hexadecylamine), HDT (hexadecylthiol), and PVP (poly(vinylpyrrolidone)). The reactivity of the Pt nanoparticles varied by 30%, with higher activity on TTAB coated nanoparticles and lower activity on HDT, while the activation energy remained between 27-28 kcal/mol. In separate experiments, the organic capping layers were partially removed using ultraviolet light-ozone generation techniques, which resulted in increased catalytic activity due to the removal of some of the organic layers. These results indicate that the nature of chemical bonding between organic capping layers and nanoparticle surfaces plays a role in determining the catalytic activity of platinum colloid nanoparticles for carbon monoxide oxidation.

  12. Peroxisome proliferator-activated receptor {gamma} is expressed in hippocampal neurons and its activation prevents {beta}-amyloid neurodegeneration: role of Wnt signaling

    SciTech Connect (OSTI)

    Inestrosa, Nibaldo C. [Centro FONDAP de Regulacion Celular y Patologia 'Joaquin V. Luco', Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago (Chile) and MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago (Chile) and Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago (Chile)]. E-mail: ninestr@genes.bio.puc.cl; Godoy, Juan A. [Centro FONDAP de Regulacion Celular y Patologia 'Joaquin V. Luco', Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago (Chile); MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago (Chile); Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago (Chile); Quintanilla, Rodrigo A. [Centro FONDAP de Regulacion Celular y Patologia 'Joaquin V. Luco', Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago (Chile); MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago (Chile); Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago (Chile); Koenig, Cecilia S. [Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago (Chile); Bronfman, Miguel [Centro FONDAP de Regulacion Celular y Patologia 'Joaquin V. Luco', Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago (Chile); MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago (Chile); Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago (Chile)

    2005-03-10T23:59:59.000Z

    The molecular pathogenesis of Alzheimer's disease (AD) involves the participation of the amyloid-{beta}-peptide (A{beta}), which plays a critical role in the neurodegeneration that triggers the disease. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors, which are members of the nuclear receptor family. We report here that (1) PPAR{gamma} is present in rat hippocampal neurons in culture. (2) Activation of PPAR{gamma} by troglitazone and rosiglitazone protects rat hippocampal neurons against A{beta}-induced neurodegeneration, as shown by the 3-[4,5 -2yl]-2,5-diphenyltetrazolium bromide (MTT) reduction assay, immunofluorescence using an anti-heavy neurofilament antibody, and quantitative electron microscopy. (3) Hippocampal neurons treated with several PPAR{gamma} agonists, including troglitazone, rosiglitazone, and ciglitazone, prevent the excitotoxic A{beta}-induced rise in bulk-free Ca{sup 2+}. (4) PPAR{gamma} activation results in the modulation of Wnt signaling components, including the inhibition of glycogen synthase kinase-3{beta} (GSK-3{beta}) and an increase of the cytoplasmic and nuclear {beta}-catenin levels. We conclude that the activation of PPAR{gamma} prevents A{beta}-induced neurodegeneration by a mechanism that may involve a cross talk between neuronal PPAR{gamma} and the Wnt signaling pathway. More important, the fact that the activation of PPAR{gamma} attenuated A{beta}-dependent neurodegeneration opens the possibility to fight AD from a new therapeutic perspective.

  13. IDENTIFYING LUMINOUS ACTIVE GALACTIC NUCLEI IN DEEP SURVEYS: REVISED IRAC SELECTION CRITERIA

    E-Print Network [OSTI]

    Donley, J. L.

    Spitzer/IRAC selection is a powerful tool for identifying luminous active galactic nuclei (AGNs). For deep IRAC data, however, the AGN selection wedges currently in use are heavily contaminated by star-forming galaxies, ...

  14. Modulation of P-glycoprotein activity in Calu-3 cells using steroids and ?-ligands

    E-Print Network [OSTI]

    Hamilton, Karen O.; Yazdanian, Mehran; Audus, Kenneth L.

    2001-01-01T23:59:59.000Z

    The purpose of this work was to investigate if P-glycoprotein (Pgp) efflux pump activity could be inhibited in the sub-bronchial epithelial cell line, Calu-3, by glucocorticosteroids and ?-ligands. The Pgp modulation ...

  15. Dysregulation of nuclear factor kappa B activity and osteopontin expression in oxidant-induced atherogenesis 

    E-Print Network [OSTI]

    Williams, Edward Spencer

    2004-09-30T23:59:59.000Z

    NF-?B activity is critical in the regulation of atherosclerotic vascular smooth muscle cell (vSMC) phenotypes induced following oxidative injury by allylamine. The present studies were designed to detail dysregulation of ...

  16. Late Holocene hurricane activity and climate variability in the Northeastern Gulf of Mexico

    E-Print Network [OSTI]

    Lane, Daniel Philip

    2011-01-01T23:59:59.000Z

    Hurricane activity in the Northeastern Gulf of Mexico and its relationship to regional and large-scale climate variability during the Late Holocene is explored. A 4500-year record of hurricane-induced storm surges is ...

  17. Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors

    SciTech Connect (OSTI)

    Powell, Noel A.; Clay, Emma H.; Holsworth, Daniel D.; Bryant, John W.; Ryan, Michael J.; Jalaie, Mehran; Zhang, Erli; Edmunds, Jeremy J. (Pfizer)

    2010-12-06T23:59:59.000Z

    We have found that both enantiomeric configurations of the 6-alkoxymethyl-1-aryl-2-piperazinone scaffold display equipotent renin inhibition activity and similar SAR patterns. This enantiomeric flexibility is in contrast to a previously reported 3-alkoxymethyl-4-arylpiperidine scaffold.

  18. Minimizing Actuator-Induced Residual Error in Active Space Telescope Primary Mirrors

    E-Print Network [OSTI]

    . Smith, David W. Miller September 2010 SSL #12-10 #12;#12;Minimizing Actuator-Induced Residual Error in Active Space Telescope Primary Mirrors Matthew W. Smith, David W. Miller September 2010 SSL #12

  19. Tracking a defined route for O2 migration in a dioxygen-activating diiron enzyme

    E-Print Network [OSTI]

    Song, Woon Ju

    For numerous enzymes reactive toward small gaseous compounds, growing evidence indicates that these substrates diffuse into active site pockets through defined pathways in the protein matrix. Toluene/o-xylene monooxygenase ...

  20. Optimization of opportunistic replacement activities: A case study in the aircraft industry

    E-Print Network [OSTI]

    Patriksson, Michael

    must there- fore be opportunistic, incorporating preventive maintenance activities within the scheduled to consider that the maintenance event is an opportunity for preventive maintenance#22;an opportunity Svensson # Abstract In the aircraft industry maximizing availability is essential. Maintenance schedules

  1. To provide national and international leadership in research, outreach and education activities which enhances cost effective-

    E-Print Network [OSTI]

    Texas at Arlington, University of

    activities which enhances cost effective- ness, construction productivity, environmental improvement Pipeline Performance Forecasting Using Neural Network Models · Analysis and Comparison of Traffic-Based Decision Matrix for Selection of Trenchless Technology Methods OBJECTIVES · Promote research in design

  2. Characterizing manufacturing activity in the United States of America : composite index of leading indicators

    E-Print Network [OSTI]

    Bustos, Felipe (Felipe Antonio Bustos Sánchez)

    2012-01-01T23:59:59.000Z

    The purpose of this work is to demonstrate that is possible to characterize the US manufacturing activity utilizing public data. Analysis of the state of the art in manufacturing metrics showed that our approach is unique ...

  3. Topological Structure of Population Activity in Primary Visual Gurjeet Singh, Facundo Memoli, Tigran Ishkhanov,

    E-Print Network [OSTI]

    Stanford University

    sensitive dyes (Grinvald and Hildesheim, 2004), appears to switch dynamically among states, some of them to study the topological structure of neural activity in cell populations of primary visual cortex

  4. Roles of key active-site residues in flavocytochrome P450 BM3

    E-Print Network [OSTI]

    Noble, Michael A.; Miles, Caroline S.; Chapman, Stephen K.; Lysek, Dominikus A.; MacKay, Angela C.; Reid, Graeme A.; Hanzlik, Robert P.; Munro, Andrew W.

    1999-01-01T23:59:59.000Z

    The effects of mutation of key active-site residues (Arg-47, Tyr-51, Phe-42 and Phe-87) in Bacillus megaterium flavocytochrome P450 BM3 were investigated. Kinetic studies on the oxidation of laurate and arachidonate showed ...

  5. A SYSTEMATIC SURVEY OF HIGH-TEMPERATURE EMISSION IN SOLAR ACTIVE REGIONS

    SciTech Connect (OSTI)

    Warren, Harry P. [Space Science Division, Naval Research Laboratory, Washington, DC 20375 (United States); Winebarger, Amy R. [NASA Marshall Space Flight Center, VP 62, Huntsville, AL 35812 (United States); Brooks, David H. [College of Science, George Mason University, 4400 University Drive, Fairfax, VA 22030 (United States)

    2012-11-10T23:59:59.000Z

    The recent analysis of observations taken with the EUV Imaging Spectrometer and X-Ray Telescope instruments on Hinode suggests that well-constrained measurements of the temperature distribution in solar active regions can finally be made. Such measurements are critical for constraining theories of coronal heating. Past analysis, however, has suffered from limited sample sizes and large uncertainties at temperatures between 5 and 10 MK. Here we present a systematic study of the differential emission measure distribution in 15 active region cores. We focus on measurements in the 'inter-moss' region, that is, the region between the loop footpoints, where the observations are easier to interpret. To reduce the uncertainties at the highest temperatures we present a new method for isolating the Fe XVIII emission in the AIA/SDO 94 A channel. The resulting differential emission measure distributions confirm our previous analysis showing that the temperature distribution in an active region core is often strongly peaked near 4 MK. We characterize the properties of the emission distribution as a function of the total unsigned magnetic flux. We find that the amount of high-temperature emission in the active region core is correlated with the total unsigned magnetic flux, while the emission at lower temperatures, in contrast, is inversely related. These results provide compelling evidence that high-temperature active region emission is often close to equilibrium, although weaker active regions may be dominated by evolving million degree loops in the core.

  6. Deciphering Active Estrogen-Degrading Microorganisms in Bioreactors

    E-Print Network [OSTI]

    Roh, Hyung Keun

    2010-10-12T23:59:59.000Z

    in biological wastewater treatment processes. This dissertation investigated factors affecting estrogen biodegradation in bioreactors. Specifically, research efforts were placed on characterization of several bacterial estrogen degraders (model strains...

  7. Trace-Element Distribution In An Active Hydrothermal System,...

    Open Energy Info (EERE)

    halo surrounding the thermal center; (4) concentrations of As in sulfides and Li in silicate alteration minerals immediately surrounding high-temperature fluid flow-controlling...

  8. Status of UFD Campaign International Activities in Disposal Research

    E-Print Network [OSTI]

    Birkholzer, J.

    2014-01-01T23:59:59.000Z

    plug in between two gravel packs and a concrete plug forplug in between two gravel packs and a concrete plug for

  9. Overview Of Electromagnetic Methods Applied In Active Volcanic...

    Open Energy Info (EERE)

    which is most sensitive to change in temperature and, therefore, can best map heat budget and hydrological character to aid in prediction of eruptions. Author Catherine K....

  10. Sport diving in Texas: a study of participants, their activity, and means of introduction

    E-Print Network [OSTI]

    O'Reilly, Margaret Byrne

    1982-01-01T23:59:59.000Z

    as an outdoor recreation activity (i. e. , sport diving). Few previous studies in leisure have described how the means of introduction to an activity affects involve- ment in that ectivity (Burch, 1969; Yoesting and Burkhead, 1973; and Yoesting.... Analysis of aggregate socio-demographic data of this type has been challenged by sev- eral researchers such as Havinghurst and Feigenbaum (1959), Burch (1969), Sofranko and Nolan (1972), and Field and O' Leary (1973). These research- ers examined...

  11. Visible light photocatalytic activity in nitrogen-doped TiO{sub 2} nanobelts

    SciTech Connect (OSTI)

    De Nyago Tafen; Lewis, James P. [Department of Physics, West Virginia University, Morgantown, West Virginia 26506 (United States); Wang Jin; Wu Nianqiang [Department of Mechanical and Aerospace Engineering, West Virginia University, Morgantown, West Virginia 26506 (United States)

    2009-03-02T23:59:59.000Z

    We present a comprehensive experimental and theoretical study of the electronic properties and photocatalytic activity of nitrogen-doped anatase TiO{sub 2} nanobelts. UV-visible spectra show enhanced absorption in the visible light range for nitrogen-doped nanobelts compared to the pristine sample. The nitrogen-doped nanobelts exhibit improved photocatalytic activity compared to the pristine sample upon visible light irradiation. Furthermore, the incorporation of nitrogen introduces localized states in the band gap.

  12. Design and analysis of active vibration control in a microgravity environment

    E-Print Network [OSTI]

    Atwood, Clay Brian

    1990-01-01T23:59:59.000Z

    DESIGN AND ANALYSIS OF ACTIVE VIBRATION CONTROL IN A MICROGRAVITY ENVIRONMENT A Thesis by CLAY BRIAN ATWOOD Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree... of MASTER OF SCIENCE May 1990 Major Subject: Mechanical Engineering DESXGN AND ANALYSIS OF ACTIVE VIBRATION CONTROL XN A MXCROGRAVXTY ENVIRONMENT A Thesis by CLAY BRIAN ATWOOD Approved as to style and content by: Richard'Alexander (Chair...

  13. Pour-depressant activity of copolymers of ethylene with vinyl acetate in diesel fuel

    SciTech Connect (OSTI)

    Dushechkin, A.P.; Ivanov, V.I.; Elagin, A.L.; Levin, A.A.

    1987-01-01T23:59:59.000Z

    The authors investigate the influence of the degree of branching of the ethylene-vinyl acetate copolymers (EVAC) on the limiting filterability temperature and the solid point of diesel fuels. EVAC samples with identical contents of vinyl acetate and having a molecular weight of 4500-7200 were used. The pour-depressant activity of the copolymers was determined in diesel fuel. It is shown that the degree of branching of EVAC has a substantial influence on the depressant activity in diesel fuel.

  14. Sustainability in Research: Geology Researcher Title Respective Activities

    E-Print Network [OSTI]

    Rose, Annkatrin

    -scale biologically deposited minerals as unconventional tracers of sewage contamination and industrial runoff in cave

  15. Civic Engagement is active involvement in the discourse

    E-Print Network [OSTI]

    Bertini, Robert L.

    in Community-based Research Erna Gelles, Institute for Nonprofit Management/ Public Administration Warren

  16. 6_07_sft_ntce_electrical:Layout 1.qxd

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and users at Argonne should exercise great vigilance in checking to see that: * Only NRTL-labeled equipment (in- cluding separate cables) or equip- ment inspected by a...

  17. Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer

    SciTech Connect (OSTI)

    Purcell, James W; Davis, Jefferson; Reddy, Mamatha; Martin, Shamra; Samayoa, Kimberly; Vo, Hung; Thomsen, Karen; Bean, Peter; Kuo, Wen Lin; Ziyad, Safiyyah; Billig, Jessica; Feiler, Heidi S; Gray, Joe W; Wood, Kenneth W; Cases, Sylvaine

    2009-06-10T23:59:59.000Z

    Ispinesib (SB-715992) is a potent inhibitor of kinesin spindle protein (KSP), a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through mitosis. Clinical studies of ispinesib have demonstrated a 9% response rate in patients with locally advanced or metastatic breast cancer, and a favorable safety profile without significant neurotoxicities, gastrointestinal toxicities or hair loss. To better understand the potential of ispinesib in the treatment of breast cancer we explored the activity of ispinesib alone and in combination several therapies approved for the treatment of breast cancer. We measured the ispinesib sensitivity and pharmacodynamic response of breast cancer cell lines representative of various subtypes in vitro and as xenografts in vivo, and tested the ability of ispinesib to enhance the anti-tumor activity of approved therapies. In vitro, ispinesib displayed broad anti-proliferative activity against a panel of 53 breast cell-lines. In vivo, ispinesib produced regressions in each of five breast cancer models, and tumor free survivors in three of these models. The effects of ispinesib treatment on pharmacodynamic markers of mitosis and apoptosis were examined in vitro and in vivo, revealing a greater increase in both mitotic and apoptotic markers in the MDA-MB-468 model than in the less sensitive BT-474 model. In vivo, ispinesib enhanced the anti-tumor activity of trastuzumab, lapatinib, doxorubicin, and capecitabine, and exhibited activity comparable to paclitaxel and ixabepilone. These findings support further clinical exploration of KSP inhibitors for the treatment of breast cancer.

  18. Rattling Nucleons: New Developments in Active Interrogation of Special Nuclear Material

    SciTech Connect (OSTI)

    Robert C. Runkle; David L. Chichester; Scott J. Thompson

    2012-01-01T23:59:59.000Z

    Active interrogation is a vigorous area of research and development due to its promise of offering detection and characterization capabilities of special nuclear material in environments where passive detection fails. The primary value added by active methods is the capability to penetrate shielding - special nuclear material itself, incidental materials, or intentional shielding - and advocates hope that active interrogation will provide a solution to the problem of detecting shielded uranium, which is at present the greatest obstacle to interdiction efforts. The technique also provides a unique benefit for quantifying nuclear material in high background-radiation environments, an area important for nuclear material safeguards and material accountancy. Progress has been made in the field of active interrogation on several fronts, most notably in the arenas of source development, systems integration, and the integration and exploitation of multiple fission and non-fission signatures. But penetration of interrogating radiation often comes at a cost, not only in terms of finance and dose but also in terms of induced backgrounds, system complexity, and extended measurement times (including set up and acquisition). These costs make the calculus for deciding to implement active interrogation more subtle than may be apparent. The purpose of this review is thus to examine existing interrogation methods, compare and contrast their attributes and limitations, and identify missions where active interrogation may hold the most promise.

  19. NIST Activities in Support of the Energy Independence and Security...

    Office of Environmental Management (EM)

    grid has become one of our Nation's top priorities, promising to reduce our dependence on oil and to meet the anticipated 1.1% annual increase in demand for electricity1. In his...

  20. Texture Control by Selective Deformation Mechanism Activation in Magnesium Alloy

    E-Print Network [OSTI]

    Foley, David Christopher

    2014-07-01T23:59:59.000Z

    The need for high strength, light weight structures in automotive and aerospace applications has driven a resurgence of interest in magnesium and its alloys. Unlike aluminum, wrought magnesium typically has a high degree of mechanical anisotropy...

  1. Active Vision and Feature Selection in Evolutionary Behavioral Systems

    E-Print Network [OSTI]

    Floreano, Dario

    disturbances. The methods overcoming the men- tioned problems aim to maintain a desired behavior in the face from a safety point of view. However, the innovations in data mining, data fusion, sensor technology

  2. Gymnasium Rules Items and activities PROHIBITED in the gymnasium

    E-Print Network [OSTI]

    or sport drinks in closed plastic containers are permitted. o No spitting on the courts or windows are allowed. Water or sport drinks in closed plastic containers are permitted. o No spitting on the courts

  3. Texture Control by Selective Deformation Mechanism Activation in Magnesium Alloy 

    E-Print Network [OSTI]

    Foley, David Christopher

    2014-07-01T23:59:59.000Z

    The need for high strength, light weight structures in automotive and aerospace applications has driven a resurgence of interest in magnesium and its alloys. Unlike aluminum, wrought magnesium typically has a high degree of mechanical anisotropy...

  4. Power Quality Improvement in Microgrid Using Advanced Active Power Conditioner

    E-Print Network [OSTI]

    unknown authors

    Abstract:- Wind energy conversion systems are now occupying important space in the research of renewable energy sources with microgrid. The main challenge in wind power generation is power quality problem and their connection with the distribution network in microgrid. The main factor behind poor

  5. Reliable Computation of Binary Parameters in Activity Coefficient Models

    E-Print Network [OSTI]

    Stadtherr, Mark A.

    phase equilibria. The technique is demonstrated with examples using the NRTL and electrolyte-NRTL (eNRTL) models. In two of the NRTL examples, results are found that contradict previous work. In the eNRTL time that a method for parameter estimation in the eNRTL model from binary LLE data (mutual solubility

  6. Sustainability in Research: Chemistry Researcher Title Respective Activities

    E-Print Network [OSTI]

    Rose, Annkatrin

    is investigating the transport and trends of air pollutants as well as the chemical and optical properties in the Babyak lab is focused I study the effect of trace elements and organic pollutants on water quality and in the development of analytical methods to detect these pollutants in water, sediment, and soil. Dr. Nicole Bennett

  7. Sustainability in Research: Physics Researcher Title Respective Activities

    E-Print Network [OSTI]

    Rose, Annkatrin

    , an ultra high vacuum chamber with a temperature controlled scanning tunneling microscope, and in-air. Lee Hawkins Mitigation of Light Pollution in North Carolina Light pollution not only spoils the view. In addition, the very light fixtures that cause light pollution cause discomfort and disability glare

  8. A Data Mining Framework for Activity Recognition In Smart Environments

    E-Print Network [OSTI]

    Cook, Diane J.

    the useful features from sensor data collected in the smart home environment and select the most important algorithms and analyze the prediction results of two different group experiments performed in the smart home, data mining and pervasive computing. In the smart home environment research, most attention has been

  9. Active Control of Nitride Plasmonic Dispersion in the Far Infrared.

    SciTech Connect (OSTI)

    Shaner, Eric A.; Dyer, Gregory Conrad; Seng, William Francis; Bethke, Donald Thomas; Grine, Albert Dario,; Baca, Albert G.; Allerman, Andrew A.

    2014-11-01T23:59:59.000Z

    We investigate plasmonic structures in nitride-based materials for far-infrared (IR) applications. The two dimensional electron gas (2DEG) in the GaN/AlGaN material system, much like metal- dielectric structures, is a patternable plasmonic medium. However, it also permits for direct tunability via an applied voltage. While there have been proof-of-principle demonstrations of plasma excitations in nitride 2DEGs, exploration of the potential of this material system has thus far been limited. We recently demonstrated coherent phenomena such as the formation of plasmonic crystals, strong coupling of tunable crystal defects to a plasmonic crystal, and electromagnetically induced transparency in GaAs/AlGaAs 2DEGs at sub-THz frequencies. In this project, we explore whether these effects can be realized in nitride 2DEG materials above 1 THz and at temperatures exceeding 77 K.

  10. Overview of Fraunhofer IPM Activities in High Temperature Bulk...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Workshop including an overview about Fraunhofer IPM, new funding situation in Germany, high temperature material and modules, energy-autarkic sensors, and thermoelectric...

  11. Blind Geothermal System Exploration in Active Volcanic Environments...

    Broader source: Energy.gov (indexed) [DOE]

    lack of surface thermal manifestation * Assessing unconventional targets requires re-tooling the standard geothermal exploration kit and adding in new tools Gravity Aeromagnetics...

  12. activity plug-in: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    surplus power they generate. Plugging in the consumer Innovating utility business models for the future, the relationship between utilities and consumers has been rather...

  13. Blind Geothermal System Exploration in Active Volcanic Environments...

    Open Energy Info (EERE)

    and Geochemical Surveys in Overt and Subtle Volcanic Systems, Hawaii and Maui Geothermal Project Jump to: navigation, search Last modified on July 22, 2011. Project Title...

  14. Review of Interests and Activities in Thermoelectric Materials...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    in thermoelectrics include integrated TE-hand-held burners for battery-replacement, waste-heat recovery on vehicles, heat-powered mobile units, and for thermoelectric cooling...

  15. Vortices in brain activity: Their mechanism and significance for perception

    E-Print Network [OSTI]

    Freeman, Walter J III

    2009-01-01T23:59:59.000Z

    of the main olfactory bulb in adult rats. Neuroscience, 64,apex rabbit olfactory bulb rabbit visual cortex phaseoutline of the olfactory bulb, on which is superimposed a 4

  16. Stantec Investigates Bat Activity in Atlantic and Great Lakes...

    Broader source: Energy.gov (indexed) [DOE]

    Maine, Great Lakes, and Mid-Atlantic coastal states regions to inform efforts to mitigate potential impacts associated with offshore wind energy development in these regions....

  17. ACTIVE CAPPING TECHNOLOGY - NEW APPROACHES FOR IN SITU REMEDIATION OF CONTAMINATED SEDIMENTS

    SciTech Connect (OSTI)

    Knox, A.; Paller, M.; Roberts, J.

    2012-02-13T23:59:59.000Z

    This study evaluated pilot-scale active caps composed of apatite, organoclay, biopolymers, and sand for the remediation of metal-contaminated sediments. The active caps were constructed in Steel Creek, at the Savannah River Site near Aiken, South Carolina. Monitoring was conducted for 12 months. Effectiveness of the caps was based on an evaluation of contaminant bioavailability, resistance to erosion, and impacts on benthic organisms. Active caps lowered metal bioavailability in the sediment during the one-year test period. Biopolymers reduced sediment suspension during cap construction, increased the pool of carbon, and lowered the release of metals. This field validation showed that active caps can effectively treat contaminants by changing their speciation, and that caps can be constructed to include more than one type of amendment to achieve multiple goals.

  18. Lattice-Strain Control of the Activity in Dealloyed Core-Shell Fuel Cell Catalysts

    SciTech Connect (OSTI)

    Strasser, P. [Berlin Institute of Technology (Technische Universitat Berlin); Koh, Shirlaine [University of Houston, Houston; Anniyev, Toyli [SLAC National Accelerator Laboratory; Greeley, Jeff [Argonne National Laboratory (ANL); More, Karren Leslie [ORNL; Yu, Chengfei [University of Houston, Houston; Liu, Zengcai [University of Houston, Houston; Kaya, Sarpa [SLAC National Accelerator Laboratory; Nordlund, Dennis [SLAC National Accelerator Laboratory; Ogasawara, Hirohito [SLAC National Accelerator Laboratory; Toney, Michael F. [SLAC National Accelerator Laboratory; Anders, Nilsson [SLAC National Accelerator Laboratory

    2010-01-01T23:59:59.000Z

    Electrocatalysis will play a key role in future energy conversion and storage technologies, such as water electrolysers, fuel cells and metal-air batteries. Molecular interactions between chemical reactants and the catalytic surface control the activity and efficiency, and hence need to be optimized; however, generalized experimental strategies to do so are scarce. Here we show how lattice strain can be used experimentally to tune the catalytic activity of dealloyed bimetallic nanoparticles for the oxygen-reduction reaction, a key barrier to the application of fuel cells and metal-air batteries. We demonstrate the core-shell structure of the catalyst and clarify the mechanistic origin of its activity. The platinum-rich shell exhibits compressive strain, which results in a shift of the electronic band structure of platinum and weakening chemisorption of oxygenated species. We combine synthesis, measurements and an understanding of strain from theory to generate a reactivity-strain relationship that provides guidelines for tuning electrocatalytic activity.

  19. Lattice-Strain Control of the Activity in Dealloyed Core-Shell Fuel Cell Catalysts

    SciTech Connect (OSTI)

    Strasser, Peter; Shirlaine, Koh; Anniyev, Toyli; Greeley, Jeffrey P.; More, Karren L.; Yu, Chengfei; Liu, Zengcai; Kaya, Sarp; Nordlund, Dennis; Ogasawara, Hirohito; Toney, Michael F.; Nilsson, Anders R.

    2010-04-30T23:59:59.000Z

    Electrocatalysis will play a key role in future energy conversion and storage technologies, such as water electrolysers, fuel cells and metal–air batteries. Molecular interactions between chemical reactants and the catalytic surface control the activity and efficiency, and hence need to be optimized; however, generalized experimental strategies to do so are scarce. Here we show how lattice strain can be used experimentally to tune the catalytic activity of dealloyed bimetallic nanoparticles for the oxygen-reduction reaction, a key barrier to the application of fuel cells and metal–air batteries. We demonstrate the core–shell structure of the catalyst and clarify the mechanistic origin of its activity. The platinum-rich shell exhibits compressive strain, which results in a shift of the electronic band structure of platinum and weakening chemisorption of oxygenated species. We combine synthesis, measurements and an understanding of strain from theory to generate a reactivity–strain relationship that provides guidelines for tuning electrocatalytic activity.

  20. Energetic particles and magnetohydrodynamic activity in the Swarthmore Spheromak Experiment

    E-Print Network [OSTI]

    Brown, Michael R.

    responsible for many observed properties of the solar atmosphere, the interplanetary medium, and other as- trophysical plasmas. Examples are found in solar flares, as well as in Coronal Mass Ejections, and other such as shocks and current sheets, and mag- netic reconnection. Populations of energized charged par- ticles

  1. Ris-R-1287(EN) Affordances in Activity Theory and

    E-Print Network [OSTI]

    is in the background. AT and CSE share the view that the actors' perception of foreground and background shifts of the ecology of work, as compared with the previous applications of Gibson's theory in HMI. ISBN 87 #12;Risø-R-1287(EN) 3 Contents 1 Introduction 6 2 Background 7 2.1 Gibson: affordances, perception

  2. Active absorption of electromagnetic pulses in a cavity

    E-Print Network [OSTI]

    Horsley, S A R; Tyc, T; Philbin, T G

    2014-01-01T23:59:59.000Z

    We show that a pulse of electromagnetic radiation launched into a cavity can be completely absorbed into an infinitesimal region of space, provided one has a high degree of control over the current flowing through this region. We work out explicit examples of this effect in a cubic cavity and a cylindrical one, and experimentally demonstrate the effect in the microwave regime.

  3. Informedness in Collaborative Networks Through Active Information Provisioning

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Database Systems 1 Introduction Companies seek to improve their competitive position by collaborating collaborate in different areas such as knowledge sharing and joint product development [1]. It also can with other companies in collaborative networks [2] that are expected to provide many potential benefits

  4. SUSTAINABLE CAMPUS ACTIVITIES IN THE UNIVERSITY OF TOKYO

    E-Print Network [OSTI]

    Miyashita, Yasushi

    -conditioners, chillers and others. A long-term target in 2030 is CO2 emission reduction by 50% in compared with 2006 students as well as collaboration with other universities. The university sets target of CO2 emission saving, Carbon dioxide emission reduction, Social collaboration Kazuaki SAKODA Masashi KAWANO Keisuke

  5. Kalman Filter Methods for Real-time Frequency and Mode Number Estimation of MHD Activity in Tokamak Plasmas

    E-Print Network [OSTI]

    Kalman Filter Methods for Real-time Frequency and Mode Number Estimation of MHD Activity in Tokamak Plasmas

  6. Safety Reports Series No. 11, Developing Safety Culture in Nuclear Activities: Practical Suggestions to Assist Progress, International Atomic Energy Agency

    Broader source: Energy.gov [DOE]

    Safety Reports Series No. 11, Developing Safety Culture in Nuclear Activities: Practical Suggestions to Assist Progress, International Atomic Energy Agency

  7. Extraordinarily Efficient Conduction in a Redox-Active Ionic Liquid

    E-Print Network [OSTI]

    Verner K. Thorsmølle; Guido Rothenberger; Daniel Topgaard; Jan C. Brauer; Dai-Bin Kuang; Shaik M. Zakeeruddin; Björn Lindman; Michael Grätzel; Jacques-E. Moser

    2010-11-09T23:59:59.000Z

    Iodine added to iodide-based ionic liquids leads to extraordinarily efficient charge transport, vastly exceeding that expected for such viscous systems. Using terahertz time-domain spectroscopy, in conjunction with dc conductivity, diffusivity and viscosity measurements we unravel the conductivity pathways in 1-methyl-3-propylimidazolium iodide melts. This study presents evidence of the Grotthuss mechanism as a significant contributor to the conductivity, and provides new insights into ion pairing processes as well as the formation of polyiodides. The terahertz and transport results are reunited in a model providing a quantitative description of the conduction by physical diffusion and the Grotthuss bond-exchange process. These novel results are important for the fundamental understanding of conduction in molten salts and for applications where ionic liquids are used as charge-transporting media such as in batteries and dye-sensitized solar cells.

  8. ENERGETIC PROTONS, RADIONUCLIDES, AND MAGNETIC ACTIVITY IN PROTOSTELLAR DISKS

    SciTech Connect (OSTI)

    Turner, N. J. [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States); Drake, J. F., E-mail: neal.turner@jpl.nasa.go [Department of Physics, Institute for Physical Science and Technology, University of Maryland, College Park, MD 20742 (United States)

    2009-10-01T23:59:59.000Z

    We calculate the location of the magnetically inactive dead zone in the minimum-mass protosolar disk, under ionization scenarios including stellar X-rays, long- or short-lived radionuclide decay, and energetic protons arriving from the general interstellar medium, from a nearby supernova explosion, from the disk corona, or from the corona of the young star. The disk contains a dead zone in all scenarios except those with small dust grains removed and a fraction of the short-lived radionuclides remaining in the gas. All the cases without exception have an 'undead zone' where intermediate resistivities prevent magneto-rotational turbulence while allowing shear-generated large-scale magnetic fields. The mass column in the undead zone is typically greater than the column in the turbulent surface layers. The results support the idea that the dead and undead zones are robust consequences of cold, dusty gas with mass columns exceeding 1000 g cm{sup -2}.

  9. Method for improved selectivity in photo-activation of molecular agents

    DOE Patents [OSTI]

    Fisher, Walter G. (Knoxville, TN); Wachter, Eric A. (Oak Ridge, TN); Dees, H. Craig (Knoxville, TN)

    1999-01-01T23:59:59.000Z

    A method for the treatment of a particular volume of plant or animal tissue comprising the steps of treating the plant or animal tissue with at least one photo-active molecular agent, wherein the particular volume of the plant or animal tissue retains at least a portion of the at least one photo-active molecular agent, and then treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of at least one of the at least one photo-active molecular agent retained in the particular volume of the plant or animal tissue, wherein the at least one photo-active molecular agent becomes active in the particular volume of the plant or animal tissue. There is also disclosed a method for the treatment of cancer in plant or animal tissue and a method for producing at least one photo-activated molecular agent in a particular volume of a material.

  10. Activity report

    SciTech Connect (OSTI)

    Yu, S W

    2008-08-11T23:59:59.000Z

    This report is aimed to show the author's activities to support the LDRD. The title is 'Investigation of the Double-C Behavior in the Pu-Ga Time-Temperature-Transformation Diagram' The sections are: (1) Sample Holder Test; (2) Calculation of x-ray diffraction patterns; (3) Literature search and preparing publications; (4) Tasks Required for APS Experiments; and (5) Communications.

  11. U.S. DEPARTl\\IENT OF ENERGY EERE PROJECT MANAGE M EN T CEN T

    Broader source: Energy.gov (indexed) [DOE]

    A9 Information gathering (inCluding, but not limited 10, literature surveys, inventories, audits). data analysis (including computer modeling), document preparation (such...

  12. u.s. DEPARUl1ENT OF ENERGY EERE PROJECT MANAGEMENT CEN T ER

    Broader source: Energy.gov (indexed) [DOE]

    A9 Information gathering (inCluding, but not limited to, literature surveys, inventories, audits), data analysis (induding computer modeling), document preparation (such as...

  13. u.s. DEPARTMENT OF ENERGY EERE PROJECT MANAG EM ENT CENTER NEPA...

    Broader source: Energy.gov (indexed) [DOE]

    A9 Information gathering (including, but not limited to. literature surveys, inventories, audits), data analysis (inCluding computer modeling), document preparation (such...

  14. Y-12 National Security Complex DOE Oak Ridge Environmental Management...

    Broader source: Energy.gov (indexed) [DOE]

    an FFA milestone of Sept. 30, 2012. The characterization strategy fol- lowed the UEFPC Remedial Action Work Plan (RAWP) and in- cluded radiation walkover surveys and soil...

  15. A method for activation analysis of ruthenium in sea water 

    E-Print Network [OSTI]

    Dixon, Bryan William

    1965-01-01T23:59:59.000Z

    of Ruthenium in the Gulf of Mexico . 8 Solubility of Ruthenium in Sea Water C H A P T E R I INTRODUCTION Ruthenium, the rarest of the platinum metals, was discovered in 1845 by Klaus. Sidgewick (1950) and Goldschmidt (1954) state an abundance of about 0... of allow ing for the detection of the contributing physical and chemical forms to the total present. It is thought that the method is applicable to marine biota and sediments as well as water samples. The concentrations of soluble ruthenium found...

  16. Effects of fluoride emissions on enzyme activity in metabolism of agricultural plants

    SciTech Connect (OSTI)

    Moeri, P.B.

    1980-01-01T23:59:59.000Z

    The effects of fluoride on the activity of malatedehydrogenase (MDH) in rape seed and rye grass have been investigated. Fluoride, which has been absorbed from the air, seems to act differently from fluoride added to the soil. The action of airborne fluoride compounds resorbed by the plant on the activity of MDH significantly correlated with the distance from an aluminum plant, crop yield, and fluoride content. 5 references, 5 figures, 2 tables.

  17. Integrating Walking for Transportation and Physical Activity for Sedentary Office Workers in Texas 

    E-Print Network [OSTI]

    Wieters, Kathleen M.

    2010-10-12T23:59:59.000Z

    and Cultural Correlates Social support for walking or companionship can influence walking levels. An Australian study of homemakers and workers (N=1803) found that the odds of achieving recommended levels of walking per day were increased as the number...., church-based social support was explored in rural communities of Missouri, Arkansas, and Tennessee (N=1625) (85). Two types of social support related to church activities were studied including direct information about improving physical activity...

  18. Interrelationships between diet, activity, body composition, and blood pressure in elderly subjects 

    E-Print Network [OSTI]

    Ideno, Katherine Tamiko

    1987-01-01T23:59:59.000Z

    Independent variables which may influence diastolic blood pressure for groups divided by use of ant i- hypertensive drugs, sex, and activity level . . . . . . 99 LIST OF FIGURES FIGURE Page 1 Scatterplot of dietary protein versus caloric in- take from 24...-hour recall 2 Scatterplot of daily caloric expenditure versus age 42 3 Scatterplot of body weight versus abdominal girth 46 4 Histogram showing distribution of sexes within groups divided by activity and use of anti- hypertensive medication 51 5...

  19. Ring diagram analysis of the characteristics of solar oscillation modes in active regions

    E-Print Network [OSTI]

    S. P. Rajaguru; Sarbani Basu; H. M. Antia

    2001-08-14T23:59:59.000Z

    The presence of intense magnetic fields in and around sunspots is expected to modify the solar structure and oscillation frequencies. Applying the ring diagram technique to data from the Michelson Doppler Imager (MDI) on board the Solar and Heliospheric Observatory (SOHO), we analyze the characteristics of high-degree f and p modes near active regions and compare them with the characteristics of the modes in quiet regions. As expected from earlier results, the f- and p-mode frequencies of high degree modes are found to be significantly larger in magnetically active regions. In addition, we find that the power in both f and p modes is lower in active regions, while the widths of the peaks are larger, indicating smaller lifetimes. We also find that the oscillation modes are more asymmetric in active regions than those in quiet regions, indicating that modes in active regions are excited closer to the surface. While the increase in mode frequency is monotonic in frequency, all other characteristics show more complex frequency dependences.

  20. NF kappa B expression and matrix metalloproteinase activity in hypertension

    E-Print Network [OSTI]

    Wu, Kwan-I

    2009-01-01T23:59:59.000Z

    J. Silica attenuates hypertension in Lyon hypertensive rats.to experimental hypertension. J. Exp. Med. 115(6):1173-1190,Hypertensive Rat. Hypertension 52(2):415-423, 2008. Fabunmi

  1. DYNAMICS OF NEURONAL ACTIVATION AND INTERACTIONS IN CORTICAL FRONTAL

    E-Print Network [OSTI]

    cortices of behaving monkeys, by using micro-electrode arrays. The monkeys performed a sensorimotor task relation between similarity in the single cells' preferred directions (PD) and their pair-wise correlation

  2. Reaction Rates and Catalysts in Ethanol Production (1 Activity...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    formation of polymers, and explosions. SEC-E: 2.c. Creativity, imagination, and a good knowledge base are required in science and engineering. SEC-E: 2.d. Science and technology...

  3. Reclaiming the commons : art and activism in the neoliberal city

    E-Print Network [OSTI]

    Berzofsky, Scott (Scott A.)

    2012-01-01T23:59:59.000Z

    How can artistic/activist practices respond to urban conditions of exclusion and inequality? Since the 1970s, urban redevelopment in the United States has been dominated by a neoliberal ideology that promotes privatization, ...

  4. A ``NEW'' APPROACH TO ACTIVE NOISE CONTROL IN DUCTS 1

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    fail to quiet. There exists a potential for reducing acoustic pollution by attenuating fan and blower of acoustic feedback which is prevalent in duct systems; see [3]. A natural approach to these adaptive schemes

  5. Results of mobile gamma scanning activities in St. Louis, Missouri

    SciTech Connect (OSTI)

    Rodriguez, R E; Witt, D A; Cottrell, W D; Carrier, R F

    1991-06-01T23:59:59.000Z

    From 1942 through approximately 1966, the Mallinckrodt Chemical Works operated four plants in St. Louis, Missouri, for the Manhattan Engineer District and the Atomic Energy Commission. A variety of production processes using uranium- and radium-bearing ore materials were performed at the plants. It is the policy of the DOE to verify that radiological conditions at such sites or facilities comply with current DOE guidelines. Guidelines for release and use of such sites have become more stringent as research has provided more information since previous cleanups. The Formerly Utilized Sites Remedial Action Program (FUSRAP) was established as part of that effort to confirm the closeout status of facilities under contract to agencies preceding DOE during early nuclear energy development. Under the FUSRAP program, the Mallinckrodt properties have been previously investigated to determine the extent of on-site radiological contamination. At the request of DOE, Oak Ridge National Laboratory (ORNL) conducted a survey in May 1990, of public roadways and suspected haul routes between the Mallinckrodt plant and storage sites in St. Louis to ensure that no residual radioactive materials were conveyed off-site. A mobile gamma scanning van with an on-board computer system was used to identify possible anomalies. Suspect areas are those displaying measurements deviating from gamma exposure rates identified as typical for radiologically unenhanced areas in the vicinity of the areas of interest. The instrumentation highlighted three anomaly locations each of which measured less than 1m{sup 2} in size. None of the slightly elevated radiation levels originated from material associated with former AEC-related processing operations in the area. The anomalies resulted from elevated concentrations of radionuclides present in phosphate fertilizers, increased thorium in road-base gravel, and emanations from the radioactive storage site near the Latty Avenue airport. 9 refs., 3 figs.

  6. Active and passive coping strategies in chronic pain patients

    E-Print Network [OSTI]

    Snow-Turek, Andrea Lynn

    1994-01-01T23:59:59.000Z

    in assisting with the data collection and providing clinical insight into the sample population; he is greatly appreciated. Don Wilson was indispensable in assisting with the data scoring and coding. His dedication, timeliness, and superior conscientiousness... various coping strategies are associated with different clinical outcomes. Many studies have found coping to be significantly related to various measures of adjustment. Treatment-outcome studies have found that programs that teach adaptive coping...

  7. SCIENCE AND TECHNOLOGY ACTIVITIES FOR CHROMIUM IN THE 100 AREAS

    SciTech Connect (OSTI)

    PETERSEN SW

    2009-07-02T23:59:59.000Z

    {sm_bullet} Primary Objective: Protect the Columbia River - Focus is control and treatment of contamination at or near the shoreline, which is influenced by bank storage {sm_bullet} Secondary Objective: Reduce hexavalent chromium to <48 parts per billion (ppb) in aquifer (drinking water standard) - Large plumes with isolated areas of high chromium concentrations (> 40,000 ppb), - Unknown source location(s); probably originating in reactor operation areas

  8. Preliminary study on hydrogeology in tectonically active areas.

    SciTech Connect (OSTI)

    Lowry, Thomas Stephen; Lappin, Allen R.; Gettemy, Glen L.; Jensen, Richard Pearson; Arnold, Bill Walter; James, Scott Carlton; Lee, Moo Yul; Meier, Diane A.

    2006-09-01T23:59:59.000Z

    This report represents the final product of a background literature review conducted for the Nuclear Waste Management Organization of Japan (NUMO) by Sandia National Laboratories, Albuquerque, New Mexico, USA. Internationally, research of hydrological and transport processes in the context of high level waste (HLW) repository performance, has been extensive. However, most of these studies have been conducted for sites that are within tectonically stable regions. Therefore, in support of NUMO's goal of selecting a site for a HLW repository, this literature review has been conducted to assess the applicability of the output from some of these studies to the geological environment in Japan. Specifically, this review consists of two main tasks. The first was to review the major documents of the main HLW repository programs around the world to identify the most important hydrologic and transport parameters and processes relevant in each of these programs. The review was to assess the relative importance of processes and measured parameters to site characterization by interpretation of existing sensitivity analyses and expert judgment in these documents. The second task was to convene a workshop to discuss the findings of Task 1 and to prioritize hydrologic and transport parameters in the context of the geology of Japan. This report details the results and conclusions of both of these Tasks.

  9. Status of exploration in the Mediterranean and future activity

    SciTech Connect (OSTI)

    Villa, C. (AGIP, Milan (Italy))

    1988-08-01T23:59:59.000Z

    During the past ten years hydrocarbon exploration in the Mediterranean region has been carried out with a reasonably enthusiastic effort. The level of offshore drilling cannot compare to the North Sea, where the number of completed wildcats has been about three times the completions registered in the Mediterranean Sea. However, only 20% of the approximate 2.5 million km{sup 2} of the Mediterranean has water depths of less than 200 m. The remaining 80% of the area is covered by deep to mostly very deep water and today is still considered a long-range frontier target for petroleum exploration. Since the major extensions of the prospective shelves are located in Italy, Libya, Tunisia, and Spain, it is logical that most of the offshore exploration has been carried out in these countries. In particular, more than 40% of these exploratory wells have been drilled in Italian waters during the past decade. Even though a couple of significant discoveries have been found, the remaining recoverable reserves have slowly and continuously diminished. Most of the Mediterranean shelf is relatively unexplored, yet future discoveries are projected to be of minor proportions.

  10. Estrogen-Related Receptor A1 Transcriptional Activities Are Regulated in Part via the ErbB2/HER2

    E-Print Network [OSTI]

    Mertz, Janet E.

    MCF-7 mammary carcinoma cells, and (b) ERRA and ErbB2 mRNA levels positively correlate in clinical breast tumors. We show here that ERRA1 represses ERA-mediated activation in MCF-7 cells because it failed plasmids. Importantly, overexpression of activated ErbB2 in MCF-7 cells led to transcriptional activation

  11. Atrial natriuretic peptide regulates lipid mobilization and oxygen consumption in human adipocytes by activating AMPK

    SciTech Connect (OSTI)

    Souza, Sandra C. [Translational Sciences - Translational Medicine, Novartis Institutes for Biomedical Research, Inc., 220 Massachusetts Avenue, Cambridge, MA 02139 (United States)] [Translational Sciences - Translational Medicine, Novartis Institutes for Biomedical Research, Inc., 220 Massachusetts Avenue, Cambridge, MA 02139 (United States); Chau, Mary D.L.; Yang, Qing [Cardiovascular and Metabolism Disease Area, Novartis Institutes for Biomedical Research, Inc., 100 Technology Square, Cambridge, MA 02139 (United States)] [Cardiovascular and Metabolism Disease Area, Novartis Institutes for Biomedical Research, Inc., 100 Technology Square, Cambridge, MA 02139 (United States); Gauthier, Marie-Soleil [Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02140 (United States)] [Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02140 (United States); Clairmont, Kevin B.; Wu, Zhidan; Gromada, Jesper [Cardiovascular and Metabolism Disease Area, Novartis Institutes for Biomedical Research, Inc., 100 Technology Square, Cambridge, MA 02139 (United States)] [Cardiovascular and Metabolism Disease Area, Novartis Institutes for Biomedical Research, Inc., 100 Technology Square, Cambridge, MA 02139 (United States); Dole, William P., E-mail: bill.dole@novartis.com [Translational Sciences - Translational Medicine, Novartis Institutes for Biomedical Research, Inc., 220 Massachusetts Avenue, Cambridge, MA 02139 (United States)

    2011-07-08T23:59:59.000Z

    Highlights: {yields} Treatment of differentiated human adipocytes with atrial natriuretic peptide (ANP) increased lipolysis and oxygen consumption by activating AMP-activated protein kinase (AMPK). {yields} ANP stimulated lipid mobilization by selective activation of the alpha2 subunit of AMPK and increased energy utilization through activation of both the alpha1 and alpha2 subunits of AMPK. {yields} ANP enhanced adipocyte mitochondrial oxidative capacity as evidenced by induction of oxidative mitochondrial genes and increase in oxygen consumption. {yields} Exposure of human adipocytes to fatty acids and (TNF{alpha}) induced insulin resistance and decreased expression of mitochondrial genes which was restored to normal by ANP. -- Abstract: Atrial natriuretic peptide (ANP) has been shown to regulate lipid and carbohydrate metabolism providing a possible link between cardiovascular function and metabolism by mediating the switch from carbohydrate to lipid mobilization and oxidation. ANP exerts a potent lipolytic effect via cGMP-dependent protein kinase (cGK)-I mediated-stimulation of AMP-activated protein kinase (AMPK). Activation of the ANP/cGK signaling cascade also promotes muscle mitochondrial biogenesis and fat oxidation. Here we demonstrate that ANP regulates lipid metabolism and oxygen utilization in differentiated human adipocytes by activating the alpha2 subunit of AMPK. ANP treatment increased lipolysis by seven fold and oxygen consumption by two fold, both of which were attenuated by inhibition of AMPK activity. ANP-induced lipolysis was shown to be mediated by the alpha2 subunit of AMPK as introduction of dominant-negative alpha2 subunit of AMPK attenuated ANP effects on lipolysis. ANP-induced activation of AMPK enhanced mitochondrial oxidative capacity as evidenced by a two fold increase in oxygen consumption and induction of mitochondrial genes, including carnitine palmitoyltransferase 1A (CPT1a) by 1.4-fold, cytochrome C (CytC) by 1.3-fold, and peroxisome proliferator-activated receptor-{gamma} coactivator-1{alpha} (PGC-1{alpha}) by 1.4-fold. Treatment of human adipocytes with fatty acids and tumor necrosis factor {alpha} (TNF{alpha}) induced insulin resistance and down-regulation of mitochondrial genes, which was restored by ANP treatment. These results show that ANP regulates lipid catabolism and enhances energy dissipation through AMPK activation in human adipocytes.

  12. DARK MATTER AS AN ACTIVE GRAVITATIONAL AGENT IN CLOUD COMPLEXES

    SciTech Connect (OSTI)

    Suarez-Madrigal, Andres; Ballesteros-Paredes, Javier; Colin, Pedro; D'Alessio, Paola, E-mail: a.suarez@crya.unam.mx [Centro de Radioastronomia y Astrofisica, Universidad Nacional Autonoma de Mexico, Apdo. Postal 72-3 (Xangari), Morelia, Michocan, Mexico C.P. 58089 (Mexico)

    2012-04-01T23:59:59.000Z

    We study the effect that the dark matter background (DMB) has on the gravitational energy content and, in general, on the star formation efficiency (SFE) of a molecular cloud (MC). We first analyze the effect that a dark matter halo, described by the Navarro-Frenk-White density profile, has on the energy budget of a spherical, homogeneous cloud located at different distances from the halo center. We found that MCs located in the innermost regions of a massive galaxy can feel a contraction force greater than their self-gravity due to the incorporation of the potential of the galaxy's dark matter halo. We also calculated analytically the gravitational perturbation that an MC produces over a uniform DMB (uniform at the scales of an MC) and how this perturbation will affect the evolution of the MC itself. The study shows that the star formation in an MC will be considerably enhanced if the cloud is located in a dense and low velocity dark matter environment. We confirm our results by measuring the SFE in numerical simulations of the formation and evolution of MCs within different DMBs. Our study indicates that there are situations where the dark matter's gravitational contribution to the evolution of the MCs should not be neglected.

  13. Role of modulation on the effect of microwaves on ornithine decarboxylase activity in L929 cells

    SciTech Connect (OSTI)

    Penafiel, L.M.; Litovitz, T.; Krause, D.; Desta, A.; Mullins, J.M. [Catholic Univ. of America, Washington, DC (United States)] [Catholic Univ. of America, Washington, DC (United States)

    1997-05-01T23:59:59.000Z

    The effect of 835 MHz microwaves on the activity of ornithine decarboxylase (ODC) in L929 murine cells was investigated at an SAR of {approximately}2.5 W/kg. The results depended upon the type of modulation employed. AM frequencies of 16 Hz and 60 Hz produced a transient increase in ODC activity that reached a peak at 8 h of exposure and returned to control levels after 24 h of exposure. In this case, ODC was increased by a maximum of 90% relative to control levels. A 40% increase in ODC activity was also observed after 8 h of exposure with a typical signal from a TDMA digital cellular telephone operating in the middle of its transmission frequency range. This signal was burst modulated at 50 Hz, with approximately 30% duty cycle. By contrast, 8 h exposure with 835 MHz microwaves amplitude modulated with speech produced no significant change in ODC activity. Further investigations, with 8 h of exposure to AM microwaves, as a function of modulation frequency, revealed that the response is frequency dependent, decreasing sharply at 6 Hz and 600 Hz. Exposure with 835 MHz microwaves, frequency modulated with a 60 Hz sinusoid, yielded no significant enhancement in ODC activity for exposure times ranging between 2 and 24 h. Similarly, exposure with a typical signal from an AMPS analog cellular telephone, which uses a form of frequency modulation, produced no significant enhancement in ODC activity. Exposure with 835 MHz continuous wave microwaves produced no effects for exposure times between 2 and 24 h, except for a small but statistically significant enhancement in ODC activity after 6 h of exposure.

  14. Recent activities in the Aerosol Generation and Transport Program

    SciTech Connect (OSTI)

    Adams, R.E.

    1984-01-01T23:59:59.000Z

    General statements may be made on the behavior of single-component and multi-component aerosols in the Nuclear Safety Pilot Plant vessel. The removal processes for U/sub 3/O/sub 8/, Fe/sub 2/O/sub 3/, and U/sub 3/O/sub 8/ + Fe/sub 2/O/sub 3/ aerosols are enhanced in a steam-air atmosphere. Steam-air seems to have little effect on removal of concrete aerosol from the vessel atmosphere. A steam-air environment causes a change in aerosol shape from chain-agglomerate to basically spherical for U/sub 3/O/sub 8/, Fe/sub 2/O/sub 3/, and U/sub 3/O/sub 8/ + Fe/sub 2/O/sub 3/ aerosol; for concrete the change in aerosol shape is from chain-agglomerate to partially spherical. The mass ratio of the individual components of a multi-component aerosol seems to have an observable influence on the resultant behavior of these aerosols in steam. The enhanced rate of removal of the U/sub 3/O/sub 8/, the Fe/sub 2/O/sub 3/, and the mixed U/sub 3/O/sub 8/ + Fe/sub 2/O/sub 3/ aerosols from the atmosphere of the NSPP vessel by steam-air is probably caused by the change in aerosol shape and the condensation of steam on the aerosol surfaces combining to increase the effect of gravitational settling. The apparent lack of an effect by steam-air on the removal rate of concrete aerosol could result from a differing physical/chemical response of the surfaces of this aerosol to condensing steam.

  15. Few-cycle dissipative solitons in active nonlinear optical fibres

    SciTech Connect (OSTI)

    Rosanov, N N; Semenov, V E; Vysotina, N V [Institute for Laser Physics, Federal State Unitary Enterprise ' Scientific and Industrial Corporation 'Vavilov State Optical Institute', St. Petersburg (Russian Federation)

    2008-02-28T23:59:59.000Z

    The propagation of self-induced transparency video pulses is studied in a waveguide containing two-level atoms of two types, which can either amplify or absorb pulses. It is shown that the amplified pulse can be compressed down to the duration comparable with the inverse frequency of the atomic transition (a few femtoseconds) along with the increase in the peak amplitude. The mechanisms restricting the compression of amplified self-induced transparency pulses are analysed (the introduction of the third atomic level and the use of the Bragg grating of the waveguide refractive index). (nonlinear optical phenomena)

  16. Materials for Consideration in Standardized Canister Design Activities.

    SciTech Connect (OSTI)

    Bryan, Charles R.; Ilgen, Anastasia Gennadyevna; Enos, David George; Teich-McGoldrick, Stephanie; Hardin, Ernest

    2014-10-02T23:59:59.000Z

    This document identifies materials and material mitigation processes that might be used in new designs for standardized canisters for storage, transportation, and disposal of spent nuclear fuel. It also addresses potential corrosion issues with existing dual-purpose canisters (DPCs) that could be addressed in new canister designs. The major potential corrosion risk during storage is stress corrosion cracking of the weld regions on the 304 SS/316 SS canister shell due to deliquescence of chloride salts on the surface. Two approaches are proposed to alleviate this potential risk. First, the existing canister materials (304 and 316 SS) could be used, but the welds mitigated to relieve residual stresses and/or sensitization. Alternatively, more corrosion-resistant steels such as super-austenitic or duplex stainless steels, could be used. Experimental testing is needed to verify that these alternatives would successfully reduce the risk of stress corrosion cracking during fuel storage. For disposal in a geologic repository, the canister will be enclosed in a corrosion-resistant or corrosion-allowance overpack that will provide barrier capability and mechanical strength. The canister shell will no longer have a barrier function and its containment integrity can be ignored. The basket and neutron absorbers within the canister have the important role of limiting the possibility of post-closure criticality. The time period for corrosion is much longer in the post-closure period, and one major unanswered question is whether the basket materials will corrode slowly enough to maintain structural integrity for at least 10,000 years. Whereas there is extensive literature on stainless steels, this evaluation recommends testing of 304 and 316 SS, and more corrosion-resistant steels such as super-austenitic, duplex, and super-duplex stainless steels, at repository-relevant physical and chemical conditions. Both general and localized corrosion testing methods would be used to establish corrosion rates and component lifetimes. Finally, it is unlikely that the aluminum-based neutron absorber materials that are commonly used in existing DPCs would survive for 10,000 years in disposal environments, because the aluminum will act as a sacrificial anode for the steel. We recommend additional testing of borated and Gd-bearing stainless steels, to establish general and localized corrosion resistance in repository-relevant environmental conditions.

  17. Review of activities in USA on HTS materials

    SciTech Connect (OSTI)

    Peterson, D.E.

    1995-02-01T23:59:59.000Z

    Rapid progress in attaining practical applications of High Temperature Superconductors (HTS) has been made since the discovery of these new materials. Many critical parameters influencing HTS powder synthesis and wire processing have been identified through a combination of fundamental exploration and applied research. The complexity of these novel materials with regard to phase behavior and physical properties has become evident as a result of these careful studies. Achieving optimal mechanical and superconducting properties in wires and tapes will require further understanding and synergy among several different technical disciplines. Highlights of efforts towards producing practical superconductors for electric power applications based on rare earth-, bismuth-, and thallium-based systems are reviewed.

  18. Measurement of bone mineral content in caged and active cats 

    E-Print Network [OSTI]

    Tveter, Diane Ellen

    1988-01-01T23:59:59.000Z

    errors but these can be reduced by using two different x-ray energies. Dual energy CT operates on a basis similar to dual photon absorptiometry (explained below). The difference in attenuation between tissue and bone is greater for a lower energy... to act as a soft tissue equivalent (35). Effects of fat and soft tissue are decreased when dual energy CT is used (33). Data from each of the two different photon energies are combined and result in images of soft tissue and bone mineral regions. Beam...

  19. The Production of Active Nitrogen in the Soil.

    E-Print Network [OSTI]

    Fraps, G. S. (George Stronach)

    1908-01-01T23:59:59.000Z

    together are taken, the differences are much smaller. If oitrates are much more valuable to plants than ammonia, these differences are very important; but if there is little difference in the value of the two, soils do not vary greatly in their power... ordx. The nitrifying power of all the soils which were probably acid were low; the limed sodium nitrate soil had a much greater ability of converting cottonseed meal into nitrates than the others. We did no' study the production of ammonia...

  20. Single Electron Charging in Optically Active Nanowire Quantum Dots

    E-Print Network [OSTI]

    with a back-gate. We combine these two field-effects to isolate a single electron and independently tune direction or by an electrostatic back-gate that modi- fies the overall potential landscape of the nanowire-6 nm high and 30 nm in diameter.10 The nanowires are contacted by a titanium (Ti) source and drain

  1. Current Research Activities in Electrode and Cell Prototyping

    Broader source: Energy.gov (indexed) [DOE]

    include: - Separator: Celgard 2325 - Trilayer PPPEPP - Electrolyte: 1.2M LiPF 6 in EC:EMC (3:7 wt%) (Tomiyama) CFF-B5A A125V Spinel CFF-B7A A12 NCM 523 CFF-B9A A12 HE5050...

  2. NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells

    SciTech Connect (OSTI)

    Pecorelli, Alessandra [Department of Molecular and Developmental Medicine, University of Siena (Italy); Child Neuropsychiatry Unit, University Hospital, AOUS, Siena (Italy); Bocci, Velio [Department of Physiology, University of Siena (Italy); Acquaviva, Alessandra [Department of Molecular and Developmental Medicine, University of Siena (Italy); Belmonte, Giuseppe [Department of Biomedical Sciences, University of Siena (Italy); Gardi, Concetta [Department of Molecular and Developmental Medicine, University of Siena (Italy); Virgili, Fabio [INRAN, Rome (Italy); Ciccoli, Lucia [Department of Molecular and Developmental Medicine, University of Siena (Italy); Valacchi, Giuseppe, E-mail: giuseppe.valacchi@unife.it [Department of Life Sciences and Biotechnology, University of Ferrara (Italy); Department of Food and Nutrition, Kyung Hee University, Seoul (Korea, Republic of)

    2013-02-15T23:59:59.000Z

    During the last decade, it has been shown that the activation of NRF2 and the binding to electrophile-responsive element (EpREs), stimulates the expression of a great number of genes responsible for the synthesis of phase I and phase II proteins, including antioxidants enzymes and heme oxygenase-1 (HO-1). This critical cell response occurs in cardiovascular, degenerative and chronic infective diseases aggravated by a chronic oxidative stress. In our previous reports we have shown that ozonated plasma is able to up-regulate HO-1 expression in endothelial cells. In the present work we investigated a candidate mechanism involved in this process. After treatment with increasing doses of ozonated serum (20, 40 and 80 ?g/mL O{sub 3} per mL of serum), a clear dose dependent activation of NRF2 and the subsequent induction of HO-1 and NAD(P)H quinone oxidoreductase 1(NQO1) was observed. This effect was also present when cells were treated with serum and hydrogen peroxide (H{sub 2}O{sub 2}) or serum and 4-hydroxynonenal (4HNE). Moreover, the treatment with ozonated serum was associated with a dose-dependent activation of extracellular-signal-regulated kinases (ERK1/2) and p38 MAP kinases (p38), not directly involved in NRF2 activation. These data, provide a new insight on the mechanism responsible for the induction of HO-1 expression by ozonated serum in the endothelium, and have a practical importance as an expedient approach to the treatment of patients with both effective orthodox drugs and ozonated autohemotherapy, targeted to the restoration of redox homeostasis. - Highlights: ? Endothelial HO1 is upregulated by ozonated plasma ? This activation is induced by NRF2 and it is ERK independent. ? 4HNE and H{sub 2}O{sub 2} are the main molecules involved in this process. ? Ozonated plasma induced a hormetic effect ? Combination of orthodox medicine and ozonated plasma can be a useful treatment.

  3. Impurity behavior during sawtooth activity in tokamak plasmas

    SciTech Connect (OSTI)

    Nicolas, T.; Garbet, X.; Sabot, R. [CEA, IRFM, F-13108 Saint-Paul-Lez-Durance (France)] [CEA, IRFM, F-13108 Saint-Paul-Lez-Durance (France); Lütjens, H.; Luciani, J.-F. [Centre de Physique Théorique, Ecole Polytechnique, CNRS, F-91128 Palaiseau Cedex (France)] [Centre de Physique Théorique, Ecole Polytechnique, CNRS, F-91128 Palaiseau Cedex (France)

    2014-01-15T23:59:59.000Z

    The transport of impurities by a sawtooth crash is simulated with the XTOR-2F code. Impurities are modeled as passive scalars, evolving in the compressible MHD flow inferred from the main MHD plasma. For a peaked impurity density profile, the non-linear kink flow of the sawtooth crash redistributes the profile efficiently and most of the particles in the peak inside the q?=?1 surface are expelled. For an initially hollow impurity density profile, the crash leads to a significant penetration up to the magnetic axis. The results are compared with Kadomtsev's model. Despite essentially different mechanisms, the evolution of the particle content inside the q?=?1 surface for Kadomtsev's model and for the non-linear case are virtually identical for the peaked profile, while the model slightly overestimates penetration for the hollow case.

  4. Carbon activation process for increased surface accessibility in electrochemical capacitors

    DOE Patents [OSTI]

    Doughty, Daniel H. (Albuquerque, NM); Eisenmann, Erhard T. (Belpre, OH)

    2001-01-01T23:59:59.000Z

    A process for making carbon film or powder suitable for double capacitor electrodes having a capacitance of up to about 300 F/cm.sup.3 is disclosed. This is accomplished by treating in aqueous nitric acid for a period of about 5 to 15 minutes thin carbon films obtained by carbonizing carbon-containing polymeric material having a high degree of molecular directionality, such as polyimide film, then heating the treated carbon film in a non-oxidizing atmosphere at a non-graphitizing temperature of at least 350.degree. C. for about 20 minutes, and repeating alternately the nitric acid step and the heating step from 7 to 10 times. Capacitors made with this carbon may find uses ranging from electronic devices to electric vehicle applications.

  5. Analyzing and Detecting Malicious Activities in Emerging Communication Platforms

    E-Print Network [OSTI]

    Yang, Chao

    2014-06-05T23:59:59.000Z

    . . . . . . . . . . . . . . . . 165 xii 1. INTRODUCTION In the recent years, with the innovation of Online Social Networking (OSN) plat- forms (e.g., Twitter and Facebook) and Smartphone platforms (e.g., Android), many people have changed their lifestyle, from posting their recent... Spam 2009 Twitter spam invades trending topics [81] Phishing 2009 A new phishing scam spreads through direct messages [56] Hosting Botnet 2009 Twitter-based Botnet Command Channel [59] Clickjacking 2010 Facebook clickjacking attack spreads through...

  6. Diffusion in shock activated Be-Al interfaces

    SciTech Connect (OSTI)

    Elliott, N.E.; Staudhammer, K.P.; Johnson, K.A.

    1987-01-01T23:59:59.000Z

    The objective of this study was to obtain initial information on the diffusion of solid aluminum clad beryllium subjected to an explosive shock loading environment. The post shock elemental concentration profiles were evaluated as a function of time and temperature. An experimental approach allows the routine and convenient observation of effects of shock pressures from roughly 1GPa to 170GPa in a single sample. The exact pressures achieved are dependent on the material being shocked.

  7. Experimental verification of active control in a microgravity environment

    E-Print Network [OSTI]

    Cordera, Joseph Frank

    1990-01-01T23:59:59.000Z

    of the proposed Space Station. Although this location eliminates accelerations induced by rotation of the Space Station, the experiment must be isolated from structural vibrations that may be caused by rotating machinery and crew push off. In order to isolate... response of the payload to various initial conditions. Results from these tests indicate a favorable comparison between the experiment and the analytical model for all controllers and free vibration. Of the three controllers, combinational control...

  8. AKT activation drives the nuclear localization of CSE1L and a pro-oncogenic transcriptional activation in ovarian cancer cells

    SciTech Connect (OSTI)

    Lorenzato, Annalisa; Biolatti, Marta [Department of Oncology, University of Torino School of Medicine, Torino (Italy); Institute for Cancer Research at Candiolo, Candiolo, Torino (Italy); Delogu, Giuseppe [Department of Biomedical Sciences-Histology, University of Sassari, Sassari (Italy); Capobianco, Giampiero [Department of Surgical, Microsurgical and Medical Sciences, University of Sassari, Sassari (Italy); Farace, Cristiano [Department of Biomedical Sciences-Histology, University of Sassari, Sassari (Italy); Dessole, Salvatore; Cossu, Antonio; Tanda, Francesco [Department of Surgical, Microsurgical and Medical Sciences, University of Sassari, Sassari (Italy); Madeddu, Roberto [Department of Biomedical Sciences-Histology, University of Sassari, Sassari (Italy); National Institute of Biostructures and Biosystems, Rome (Italy); Olivero, Martina [Department of Oncology, University of Torino School of Medicine, Torino (Italy); Institute for Cancer Research at Candiolo, Candiolo, Torino (Italy); Di Renzo, Maria Flavia, E-mail: mariaflavia.direnzo@unito.it [Department of Oncology, University of Torino School of Medicine, Torino (Italy); Institute for Cancer Research at Candiolo, Candiolo, Torino (Italy)

    2013-10-15T23:59:59.000Z

    The human homolog of the yeast cse1 gene (CSE1L) is over-expressed in ovarian cancer. CSE1L forms complex with Ran and importin-? and has roles in nucleocytoplasmic traffic and gene expression. CSE1L accumulated in the nucleus of ovarian cancer cell lines, while it was localized also in the cytoplasm of other cancer cell lines. Nuclear localization depended on AKT, which was constitutively active in ovarian cancer cells, as the CSE1L protein translocated to the cytoplasm when AKT was inactivated. Moreover, the expression of a constitutively active AKT forced the translocation of CSE1L from the cytoplasm to the nucleus in other cancer cells. Nuclear accrual of CSE1L was associated to the nuclear accumulation of the phosphorylated Ran Binding protein 3 (RanBP3), which depended on AKT as well. Also in samples of human ovarian cancer, AKT activation was associated to nuclear accumulation of CSE1L and phosphorylation of RanBP3. Expression profiling of ovarian cancer cells after CSE1L silencing showed that CSE1L was required for the expression of genes promoting invasion and metastasis. In agreement, CSE1L silencing impaired motility and invasiveness of ovarian cancer cells. Altogether these data show that in ovarian cancer cells activated AKT by affecting RanBP3 phosphorylation determines the nuclear accumulation of CSE1L and likely the nuclear concentration of transcription factors conveying pro-oncogenic signals. - highlights: • CSE1L is a key player in nucleocytoplasmic traffic by forming complex with Ran. • AKT phosphorylates RanBP3 that regulates the nucleocytoplasmic gradient of Ran. • The activated oncogenic AKT drives the nuclear accumulation of CSE1L. • CSE1L in the nucleus up-regulates genes conveying pro-oncogenic signals. • CSE1L might contribute to tumor progression driven by the activated oncogenic AKT.

  9. Tritium control and activation in the Pulse*Star reactor

    SciTech Connect (OSTI)

    Blink, J.A.; Hoffman, N.J.

    1983-12-01T23:59:59.000Z

    Pulse*Star is an inertial fusion reactor that uses LiPb coolant in a pool type geometry. LiPb does not release great quantities of chemical energy in a fire, and the pool geometry reduces the difficulty of safely transporting the extremely dense fluid. The compact geometry and good neutronics qualities of LiPb lead to a thermal-to-fusion energy ratio of 1.26, a tritium breeding ratio of 1.22, and a net electric power density 29 times higher than in a fission reactor containment building. The afterheat of the coolant and steel is low enough that emergency cooling systems will be either simple or not required. The gamma dose rate of the bell jar or screen is high enough to require remote maintenance of these components. The steam generators and pumps are on the borderline between limited hands-on and remote maintenance. With additional design attention, limited hands-on maintenance could be feasible for these components. The biological hazard potential indicates that only 10/sup -7/ to 10/sup -6/ of the reactor central region can be vaporized and released; these are values typical of other fusion reactor designs.

  10. Active patterning and asymmetric transport in a model actomyosin network

    E-Print Network [OSTI]

    Shenshen Wang; Peter G. Wolynes

    2014-12-19T23:59:59.000Z

    Cytoskeletal networks, which are essentially motor-filament assemblies, play a major role in many developmental processes involving structural remodeling and shape changes. These are achieved by nonequilibrium self-organization processes that generate functional patterns and drive intracellular transport. We construct a minimal physical model that incorporates the coupling between nonlinear elastic responses of individual filaments and force-dependent motor action. By performing stochastic simulations we show that the interplay of motor processes, described as driving anti-correlated motion of the network vertices, and the network connectivity, which determines the percolation character of the structure, can indeed capture the dynamical and structural cooperativity which gives rise to diverse patterns observed experimentally. The buckling instability of individual filaments is found to play a key role in localizing collapse events due to local force imbalance. Motor-driven buckling-induced node aggregation provides a dynamic mechanism that stabilizes the two dimensional patterns below the apparent static percolation limit. Coordinated motor action is also shown to suppress random thermal noise on large time scales, the two dimensional configuration that the system starts with thus remaining planar during the structural development. By carrying out similar simulations on a three dimensional anchored network, we find that the myosin-driven isotropic contraction of a well-connected actin network, when combined with mechanical anchoring that confers directionality to the collective motion, may represent a novel mechanism of intracellular transport, as revealed by chromosome translocation in the starfish oocyte.

  11. Oxidative stress plays a role in high glucose-induced activation of pancreatic stellate cells

    SciTech Connect (OSTI)

    Ryu, Gyeong Ryul; Lee, Esder; Chun, Hyun-Ji; Yoon, Kun-Ho; Ko, Seung-Hyun; Ahn, Yu-Bae; Song, Ki-Ho, E-mail: kihos@catholic.ac.kr

    2013-09-20T23:59:59.000Z

    Highlights: •High glucose increased production of reactive oxygen species in cultured pancreatic stellate cells. •High glucose facilitated the activation of these cells. •Antioxidant treatment attenuated high glucose-induced activation of these cells. -- Abstract: The activation of pancreatic stellate cells (PSCs) is thought to be a potential mechanism underlying islet fibrosis, which may contribute to progressive ?-cell failure in type 2 diabetes. Recently, we demonstrated that antioxidants reduced islet fibrosis in an animal model of type 2 diabetes. However, there is no in vitro study demonstrating that high glucose itself can induce oxidative stress in PSCs. Thus, PSCs were isolated and cultured from Sprague Dawley rats, and treated with high glucose for 72 h. High glucose increased the production of reactive oxygen species. When treated with high glucose, freshly isolated PSCs exhibited myofibroblastic transformation. During early culture (passage 1), PSCs treated with high glucose contained an increased number of ?-smooth muscle actin-positive cells. During late culture (passages 2–5), PSCs treated with high glucose exhibited increases in cell proliferation, the expression of fibronectin and connective tissue growth factor, release of interleukin-6, transforming growth factor-? and collagen, and cell migration. Finally, the treatment of PSCs with high glucose and antioxidants attenuated these changes. In conclusion, we demonstrated that high glucose increased oxidative stress in primary rat PSCs, thereby facilitating the activation of these cells, while antioxidant treatment attenuated high glucose-induced PSC activation.

  12. CHROMOSPHERICALLY ACTIVE STARS IN THE RADIAL VELOCITY EXPERIMENT (RAVE) SURVEY. I. THE CATALOG

    SciTech Connect (OSTI)

    Žerjal, M.; Zwitter, T. [Faculty of Mathematics and Physics, University of Ljubljana, Jadranska 19, 1000 Ljubljana (Slovenia); Matijevi?, G. [Department of Astronomy and Astrophysics, Villanova University, 800 E Lancaster Avenue, Villanova, PA 19085 (United States); Strassmeier, K. G.; Siviero, A.; Steinmetz, M. [Leibniz-Institut für Astrophysik Potsdam (AIP), An der Sternwarte 16, D-14482 Potsdam (Germany); Bienaymé, O. [Observatoire astronomique de Strasbourg, Université de Strasbourg, CNRS, 11 rue de l'Université, F-67000 Strasbourg (France); Bland-Hawthorn, J. [Sydney Institute for Astronomy, School of Physics A28, Sydney, NSW 2006 (Australia); Boeche, C.; Grebel, E. K. [Astronomisches Rechen-Institut, Zentrum für Astronomie der Universität Heidelberg, Mönchhofstr. 12-14, D-69120 Heidelberg (Germany); Freeman, K. C. [Research School of Astronomy and Astrophysics, Australia National University, Weston Creek, Canberra, ACT 2611 (Australia); Kordopatis, G. [Institute of Astronomy, Cambridge University, Madingley Road, Cambridge CB3 0HA (United Kingdom); Munari, U. [INAF Osservatorio Astronomico di Padova, I-36012 Asiago (Italy); Navarro, J. F. [Department of Physics and Astronomy, University of Victoria, Victoria BC, V8P 5C2 (Canada); Parker, Q. A.; Reid, W. [Department of Physics and Astronomy, Macquarie University, Sydney, NSW 2109 (Australia); Seabroke, G. [Mullard Space Science Laboratory, University College London, Holmbury St Mary, Dorking, RH5 6NT (United Kingdom); Wyse, R. F. G., E-mail: marusa.zerjal@fmf.uni-lj.si [Johns Hopkins University, Homewood Campus, 3400 North Charles Street, Baltimore, MD 21218 (United States)

    2013-10-20T23:59:59.000Z

    RAVE, the unbiased magnitude limited survey of southern sky stars, contained 456,676 medium-resolution spectra at the time of our analysis. Spectra cover the Ca II infrared triplet (IRT) range, which is a known indicator of chromospheric activity. Our previous work classified all spectra using locally linear embedding. It identified 53,347 cases with a suggested emission component in calcium lines. Here, we use a spectral subtraction technique to measure the properties of this emission. Synthetic templates are replaced by the observed spectra of non-active stars to bypass the difficult computations of non-local thermal equilibrium profiles of the line cores and stellar parameter dependence. We derive both the equivalent width of the excess emission for each calcium line on a 5 Å wide interval and their sum EW{sub IRT} for ?44,000 candidate active dwarf stars with signal-to-noise ratio >20, with no cuts on the basis of the source of their emission flux. From these, ?14,000 show a detectable chromospheric flux with at least a 2? confidence level. Our set of active stars vastly enlarges previously known samples. Atmospheric parameters and, in some cases, radial velocities of active stars derived from automatic pipelines suffer from systematic shifts due to their shallower calcium lines. We re-estimate the effective temperature, metallicity, and radial velocities for candidate active stars. The overall distribution of activity levels shows a bimodal shape, with the first peak coinciding with non-active stars and the second with the pre-main-sequence cases. The catalog will be made publicly available with the next RAVE public data releases.

  13. Ureides in active and nitrate-repressed soybean nodules

    E-Print Network [OSTI]

    Bundy, Timothy K.

    1983-01-01T23:59:59.000Z

    ) detected ureides in his final preparations of two acid soluble peptides which seemed to be associated with nitrogen fixation. He presented evidence that these crude preparations were able to: A) bind and release NH ; and 8) reduce the triple bond... (----1 of nitrate, were analyzed on a Beckman 120B automatic amino acid analyzer. The post arginine peaks (I, II, III) were measured. 38 Table 4. The Effect of N03 on Acid-Soluble Peptide(s) from Soybean Nodules. Acid-soluble ex- tracts were...

  14. Structure-activity relationships in olefin polymerization catalysts

    E-Print Network [OSTI]

    Price, Craig Justin

    2009-05-15T23:59:59.000Z

    of homogeneous ?-diimine catalysts to produce high molecular weigh polyethylene with a branched structure gives rise to unique properties.22-26 In addition, homogeneous metallocene and ansa-metallocene complexes, such as Me2C(?5-C5H 4)(?5- C13H8)ZrCl2...LYP/6-31G?). According to the DFT calculations, the formation of an alternating copolymer is exothermic (?H = - 4.31 kcal/mol per repeat unit), but endergonic at most temperatures (> -159?C, the ceiling temperature), and is therefore practically...

  15. Overview of Fraunhofer IPM Activities in High Temperature Bulk Materials

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn'tOrigin of Contamination in ManyDepartmentOutreach toTransmission and6/15/2015 U.SClimate

  16. Overview of Joining Activities in Lightweighting Materials | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn'tOrigin of Contamination in ManyDepartmentOutreach toTransmissionProgram |andJapanese

  17. In-Reach/Outreach Activities | Y-12 National Security Complex

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh SchoolIn Other News Community Connections: Your

  18. In-Vacuum Active Electronics for Microfabricated Ion Traps

    E-Print Network [OSTI]

    Nicholas D. Guise; Spencer D. Fallek; Harley Hayden; C-S Pai; Curtis Volin; K. R. Brown; J. True Merrill; Alexa W. Harter; Jason M. Amini; Lisa M. Lust; Kelly Muldoon; Doug Carlson; Jerry Budach

    2014-06-02T23:59:59.000Z

    The advent of microfabricated ion traps for the quantum information community has allowed research groups to build traps that incorporate an unprecedented number of trapping zones. However, as device complexity has grown, the number of digital-to-analog converter (DAC) channels needed to control these devices has grown as well, with some of the largest trap assemblies now requiring nearly one hundred DAC channels. Providing electrical connections for these channels into a vacuum chamber can be bulky and difficult to scale beyond the current numbers of trap electrodes. This paper reports on the development and testing of an in-vacuum DAC system that uses only 9 vacuum feedthrough connections to control a 78-electrode microfabricated ion trap. The system is characterized by trapping single and multiple $^{40}$Ca$^+$ ions. The measured axial mode stability, ion heating rates, and transport fidelities for a trapped ion are comparable to systems with external(air-side) commercial DACs.

  19. Solar-induced thermal activity and stratification in pond water

    E-Print Network [OSTI]

    Brownridge, James D

    2015-01-01T23:59:59.000Z

    Ponds are universally used to store water for a large number of uses. With the increasing demand for more fresh water, ponds, lakes and reservoirs are likely to be constructed on a larger scale. We must understand the effects of environmental changes on fresh water if we are to most efficiently utilize this resource. This study undertakes to increase our understanding of the rate of thermal response of ponds and other bodies of water to every-day environmental changes. The central research agenda is to investigate how the temperature of pond water from top to bottom responds to the day/night cycle, changes in air temperature just above the surface, cloud conditions, and other sudden environmental changes. Data collection for this study spanned October 2007 to June 2011 and had a continuous time resolution of 50 seconds.

  20. Results of mobile gamma scanning activities in Tonawanda, New York

    SciTech Connect (OSTI)

    Cottrell, W.D.; Witt, D.A.; Rodriguez, R.E.; Carrier, R.F.

    1990-12-01T23:59:59.000Z

    During the 1940s, the Linde Air Products Division of Union Carbide operated a plant in Tonawanda, New York, for the Manhattan Engineer District (MED) and the Atomic Energy Commission (AEC). Uranium production and some nickel processing were conducted at the site. It is the policy of the US Department of Energy (DOE) to verify that radiological conditions at such sites or facilities comply with current DOE guidelines. Guidelines for release and use of such sites have become more stringent as research has provided more information since previous cleanups. The Formerly Utilized Sites Remedial Action Program (FUSRAP) was established as part of that effort to confirm the closeout status of facilities under contract to agencies preceding DOE during early nuclear energy development. Under the FUSRAP program, the Linde site itself has been previously investigated to determine the extent of on-site radiological contamination. As a precaution to insure that no residual radioactive materials were transported off-site, the Department of Energy requested that ORNL survey the area in the vicinity of the Linde Plant, the waste water treatment facility on Tower Road, the Sheridan Park Fire Station (District 4), and the Tonawanda Landfill to assess whether any residual radioactive material could be detected. The survey was conducted the week of April 3, 1990. Results of analysis of soil samples from the Tonawanda Landfill revealed slightly elevated concentrations of {sup 238}U and {sup 226}Ra suggestive of residuals from former Linde Plant operations. Therefore, it is recommended that additional surveying of the landfill property and of Sheridan Creek from south of the Linde property to its confluence with the Niagara River be conducted. The survey should include the measurement of gamma radiation levels and radionuclide analysis of silt samples. 6 refs., 4 figs., 1 tab.

  1. Measurement of the thorium-228 activity in solutions cavitated by ultrasonic sound

    E-Print Network [OSTI]

    R. Ford; M. Gerbier-Violleau; E. Vazquez-Jauregui

    2009-11-10T23:59:59.000Z

    We show that cavitation of a solution of thorium-228 in water does not induce its transformation at a faster rate than the natural radioactive decay. We measured the activity of a thorium-228 solution in water before, and after, it was subjected to a cavitation at 44 kHz and $250 $W for 90 minutes in order to observe any change in the thorium half-life. The results were compared to the original activity of the sample and we observed no change. Our results and conclusions conflict with those in a recent paper by F. Cardone et. al. [Phys. Lett. A 373 (2009) 1956-1958].

  2. Dynamical Handling of Straddle Carriers Activities on a Container Terminal in Uncertain Environment

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Dynamical Handling of Straddle Carriers Activities on a Container Terminal in Uncertain precisely straddle carriers in a container terminal. The information given by such a tool makes an optimization possible. In fact, a box terminal is an open system subject to dynamics, in which many events can

  3. Activation and promotion studies in a mixed slurry reactor with an iron-manganese Fischer-Tropsch catalyst

    SciTech Connect (OSTI)

    Pennline, H.W.; Zarochak, M.F.; Stencel, J.M.; Diehl, J.R.

    1987-03-01T23:59:59.000Z

    Synthesis gas was reacted over a coprecipitated iron-manganese Fischer-Tropsch catalyst in a slurry reactor. The effect of various activation parameters - temperature, pressure, and gas composition - on subsequent catalyst activity and product selectivity was investigated. The gas composition had the most dramatic effect on the catalyst activation and the ensuing synthesis gas conversion. The effect of potassium promotion on catalyst activity and product selectivity was also studied in slurry reactor tests.

  4. A possible relationship between Global Warming and Lightning Activity in India during the period 1998-2009

    E-Print Network [OSTI]

    Felix Pereira B.; Priyadarsini G.; T. E. Girish

    2010-12-15T23:59:59.000Z

    Lightning activity on a global scale has been studied season wise using satellite data for the period from 1998 to 2009. Lightning activity shows an increasing trend during the period of study which is highly correlated with atmospheric warming. A similar increasing trend of lightning activity is observed in the Indian region during the pre-monsoon season which is correlated with global lightning trends and warming trends of surface temperature in India. Key words: Global warming, lightning activity, Solar cycle changes

  5. In vitro - in vivo correlations for endocrine activity of a mixture of currently used pesticides

    SciTech Connect (OSTI)

    Taxvig, Camilla, E-mail: camta@food.dtu.dk [Division of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK-2860 Søborg (Denmark); Hadrup, Niels; Boberg, Julie; Axelstad, Marta [Division of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK-2860 Søborg (Denmark); Bossi, Rossana [Department of Environmental Science, Aarhus University, DK-4000 Roskilde (Denmark); Bonefeld-Jørgensen, Eva Cecilie [Department of Public Health, University of Aarhus, DK-8000 Aarhus C (Denmark); Vinggaard, Anne Marie [Division of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK-2860 Søborg (Denmark)

    2013-11-01T23:59:59.000Z

    Two pesticide mixtures were investigated for potential endocrine activity. Mix 3 consisted of bitertanol, propiconazole, and cypermethrin, and Mix 5 included malathion and terbuthylazine in addition to the three pesticides in Mix 3. All five single pesticides and the two mixtures were investigated for their ability to affect steroidogenesis in vitro in H295R cells. The pesticides alone and both mixtures affected steroidogenesis with both mixtures causing increase in progesterone and decrease in testosterone. For Mix 5 an increase in estradiol was seen as well, indicating increased aromatase activity. The two mixtures were also investigated in pregnant rats dosed from gestational day 7 to 21, followed by examination of dams and fetuses. Decreased estradiol and reduced placental testosterone were seen in dams exposed to Mix 5. Also a significant increase in aromatase mRNA-levels in female adrenal glands was found for Mix5. However, either of the two mixtures showed any effects on fetal hormone levels in plasma or testis, or on anogenital distance. Overall, potential aromatase induction was found for Mix 5 both in vitro and in vivo, but not for Mix 3, an effect likely owed to terbuthylazine in Mix 5. However, the hormonal responses in vitro were only partly reflected in vivo, probably due to some toxicokinetic issues, as the pesticide levels in the amniotic fluid also were found to be negatively affected by the number of compounds present in the mixtures. Nonetheless, the H295R assay gives hints on conceivable interference with steroidogenesis, thus generating hypotheses on in vivo effects. - Highlights: • The study examines the endocrine disrupting potential of mixtures of pesticides. • All single pesticides and both mixtures affected steroidogenesis in vitro. • Potential aromatase induction was found for Mix 5 both in vitro and in vivo. • The hormonal responses in vitro were only partly reflected in vivo.

  6. Free energy, entropy and volume of activation for electron transfer reactions in a polar solvent

    SciTech Connect (OSTI)

    Manjari, Swati R.; Kim, Hyung J. [Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213 (United States)

    2006-07-07T23:59:59.000Z

    A continuum theory with account of cavity size fluctuations is employed to study free energy, volume and entropy of activation for nonadiabatic electron transfer (ET) reactions in polar solvents. By using a two-sphere cavity description, model calculations are performed for charge separation and recombination processes in acetonitrile under ambient conditions. It is found that the cavity size at the transition state varies with the free energy of reaction as well as with the thermodynamic conditions. In contrast to the Marcus theory predictions, the volume and entropy of activation show a monotonic behavior with the free energy of reaction and a strong correlation with each other. For example, for a given ET process, the volume and entropy of activation have the same sign. Their values for the charge separation and recombination processes are opposite in sign. These findings are in good qualitative agreement with measurements.

  7. Environmental determinants of active travel in youth: A review and framework for future research

    E-Print Network [OSTI]

    Panter, Jenna R; Jones, Andrew P; van Sluijs, Esther M F

    2008-06-23T23:59:59.000Z

    in the neighbourhood were more connected. Schlossberg 2005 [52] 104 U US Middle school (˜11– 14) CS, O Objectively assessed network and straight line distance to school Parental report of walking or cycling to school frequency. More likely to actively commute... in the neighbourhood, and who had to cross busy roads to get to school, were less likely to actively travel to school. Carver et al. [25] found that in adolescent girls, perceptions of safe roads in the neighbourhood were positively associated with walking...

  8. A Tale of Two Isomerases: Compact versus Extended Active Sites in Ketosteroid Isomerase and Phosphoglucose Isomerase

    SciTech Connect (OSTI)

    Somarowthu, Srinivas; Brodkin, Heather R.; D’ Aquino, J. Alejandro; Ringe, Dagmar; Ondrechen, Mary Jo; Beuning, Penny J. (Brandeis); (NEU)

    2012-07-11T23:59:59.000Z

    Understanding the catalytic efficiency and specificity of enzymes is a fundamental question of major practical and conceptual importance in biochemistry. Although progress in biochemical and structural studies has enriched our knowledge of enzymes, the role in enzyme catalysis of residues that are not nearest neighbors of the reacting substrate molecule is largely unexplored experimentally. Here computational active site predictors, THEMATICS and POOL, were employed to identify functionally important residues that are not in direct contact with the reacting substrate molecule. These predictions then guided experiments to explore the active sites of two isomerases, Pseudomonas putida ketosteroid isomerase (KSI) and human phosphoglucose isomerase (PGI), as prototypes for very different types of predicted active sites. Both KSI and PGI are members of EC 5.3 and catalyze similar reactions, but they represent significantly different degrees of remote residue participation, as predicted by THEMATICS and POOL. For KSI, a compact active site of mostly first-shell residues is predicted, but for PGI, an extended active site in which residues in the first, second, and third layers around the reacting substrate are predicted. Predicted residues that have not been previously tested experimentally were investigated by site-directed mutagenesis and kinetic analysis. In human PGI, single-point mutations of the predicted second- and third-shell residues K362, H100, E495, D511, H396, and Q388 show significant decreases in catalytic activity relative to that of the wild type. The results of these experiments demonstrate that, as predicted, remote residues are very important in PGI catalysis but make only small contributions to catalysis in KSI.

  9. Quantum delocalization of protons in the hydrogen bond network of an enzyme active site

    E-Print Network [OSTI]

    Wang, Lu; Boxer, Steven G; Markland, Thomas E

    2015-01-01T23:59:59.000Z

    Enzymes utilize protein architectures to create highly specialized structural motifs that can greatly enhance the rates of complex chemical transformations. Here we use experiments, combined with ab initio simulations that exactly include nuclear quantum effects, to show that a triad of strongly hydrogen bonded tyrosine residues within the active site of the enzyme ketosteroid isomerase (KSI) facilitates quantum proton delocalization. This delocalization dramatically stabilizes the deprotonation of an active site tyrosine residue, resulting in a very large isotope effect on its acidity. When an intermediate analog is docked, it is incorporated into the hydrogen bond network, giving rise to extended quantum proton delocalization in the active site. These results shed light on the role of nuclear quantum effects in the hydrogen bond network that stabilizes the reactive intermediate of KSI, and the behavior of protons in biological systems containing strong hydrogen bonds.

  10. A STUDY OF ACTIVATED SLUDGE DEWATERING IN EXPERIMENTAL REED-PLANTED OR UNPLANTED SLUDGE

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    94/0169 A STUDY OF ACTIVATED SLUDGE DEWATERING IN EXPERIMENTAL REED-PLANTED OR UNPLANTED SLUDGE of the reeds in bed 2 died in spite of the influent sludge dose of 70 g. of SS.m"2.d~l. During the second phase (917 days) the 3 beds were aerated from the bottom and fed with sludge, directly extracted from

  11. Differential activation of bovine T lymphocyte subpopulations in response to mitogen and superantigen stimulation

    E-Print Network [OSTI]

    Keahey, Jennifer Leigh

    2000-01-01T23:59:59.000Z

    ). Activation studies have been done with PWM in bovme leukemia virus (BLV)-infected cattle (42), and analysis has been done of T cell subset alterations in cattle infected with bovine viral diarrhea virus (BVDV) (10). Work in cattle experiencing any...

  12. Browne, CB, Research Proposal, March 2009 Activation of the Inflammasome in Gout

    E-Print Network [OSTI]

    Gleeson, Joseph G.

    Browne, CB, Research Proposal, March 2009 1 Activation of the Inflammasome in Gout Background Gout. The overall prevalence of gout in the U.S. was determined to be 41 in 1000 (1). Men are at a higher risk than women for gout, and the risk increases with age for both males and females (1). The initiation

  13. ERK activation is required for hydrostatic pressure-induced tensile changes in

    E-Print Network [OSTI]

    Athanasiou, Kyriacos

    ERK activation is required for hydrostatic pressure-induced tensile changes in engineered articular, Davis, CA, USA Abstract The objective of this study was to identify ERK 1/2 involvement in the changes-assembled cartilage constructs. In study 1, ERK 1/2 phosphorylation was detected by immunoblot, following application

  14. METHODOLOGICAL PROPOSAL FOR THE ACTIVATION OF LOCALIZED AGROALIMENTARY SYSTEMS IN ARGENTINA

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    METHODOLOGICAL PROPOSAL FOR THE ACTIVATION OF LOCALIZED AGROALIMENTARY SYSTEMS IN ARGENTINA Profesor Adjunto Irene Velarde Abstract : Argentina, a country which produces foods for the world SYSTEMS IN ARGENTINA halshs-00535617,version1-19Mar2013 Author manuscript, published in "8th International

  15. Analysis of patent activity in the field of quantum information processing

    E-Print Network [OSTI]

    Ryszard Winiarczyk; Piotr Gawron; Jaros?aw Adam Miszczak; ?ukasz Pawela; Zbigniew Pucha?a

    2012-12-11T23:59:59.000Z

    This paper provides an analysis of patent activity in the field of quantum information processing. Data from the PatentScope database from the years 1993-2011 was used. In order to predict the future trends in the number of filed patents time series models were used.

  16. Analysis of patent activity in the field of quantum information processing

    E-Print Network [OSTI]

    Winiarczyk, Ryszard; Miszczak, Jaros?aw Adam; Pawela, ?ukasz; Pucha?a, Zbigniew

    2013-01-01T23:59:59.000Z

    This paper provides an analysis of patent activity in the field of quantum information processing. Data from the PatentScope database from the years 1993-2011 was used. In order to predict the future trends in the number of filed patents time series models were used.

  17. Independent Activation of Cold Acclimation by Low Temperature and Short Photoperiod in Hybrid Aspen1

    E-Print Network [OSTI]

    Palva, Tapio

    Independent Activation of Cold Acclimation by Low Temperature and Short Photoperiod in Hybrid Aspen hybrid aspen (Populus tremula Populus tremuloides Michx.) line 22 overexpressing the oat (Avena sativaA in daylength sensing of woody plants. Overexpression of oat (Avena sativa) phyA gene (PHYA) in hybrid aspen

  18. REDUCING MISMATCH LOSSES IN GRID-CONNECTED RESIDENTIAL BIPV ARRAYS USING ACTIVE POWER CONVERSION COMPONENTS

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    in plant energy production. The introduction of additional power converters in the plant layout intends/Simulink© environment for each topology using a 3 kWp rooftop-type plant. Simulation results show that a considerableREDUCING MISMATCH LOSSES IN GRID-CONNECTED RESIDENTIAL BIPV ARRAYS USING ACTIVE POWER CONVERSION

  19. A possible role of social activity to explain differences in publication output among ecologists

    E-Print Network [OSTI]

    Nachman, Michael

    activities in the world is drinking alcohol. In Europe, most alcohol is consumed as beer and, based on well correlations between beer consumption and several measures of scientific performance. Using a survey from the Czech Republic, that has the highest per capita beer consumption rate in the world, I show

  20. Patterns of Proliferative Activity in the Colonic Crypt Determine Crypt Stability and Rates of Somatic Evolution

    E-Print Network [OSTI]

    , United States of America Abstract Epithelial cells in the colon are arranged in cylindrical structures States, accounting for 9% of all cancer deaths [1]. This large incidence can be partially attributedPatterns of Proliferative Activity in the Colonic Crypt Determine Crypt Stability and Rates

  1. Salt Sensitivity and the Activities of the H+ -ATPases in Cotton Seedlings

    E-Print Network [OSTI]

    Schumaker, Karen

    Salt Sensitivity and the Activities of the H+ -ATPases in Cotton Seedlings Howard Lin, Sandra S environ- ments. Sensitivityto high levels of salt in plants is associated with an inability to effectively+ -pumping ATPases may provide the driving force for Na+ transport via Na+ -H+ exchangers. In a salt

  2. Random perturbations of spiking activity in a pair of coupled neurons

    E-Print Network [OSTI]

    Random perturbations of spiking activity in a pair of coupled neurons Boris Gutkin , J¨urgen Jost on the firing be- haviour of two coupled Type 1 or Type 2 neurons. In Hodgkin-Huxley model neurons with standard that regular spiking and fast spiking neurons in the rat somatosensory cortex exhibit Type 1 and Type 2 firing

  3. Embedding metal electrodes in thick active layers for ITO-free plasmonic organic solar cells

    E-Print Network [OSTI]

    Park, Namkyoo

    Embedding metal electrodes in thick active layers for ITO-free plasmonic organic solar cells%) in optical absorption over both a conventional ITO organic solar cell and a conventional plasmonic organic solar cell with top-loaded metallic grating is predicted in the proposed structure. Optimal positioning

  4. fMRI visualisation of transient activations in the rat olfactory bulb using short odour stimulations

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    fMRI visualisation of transient activations in the rat olfactory bulb using short odour in the olfactory bulb OB displays both spatial and temporal organization. The difficulty when assessing spatio of the olfactory bulb (OB). Hence, in this structure, the identity of odorants is associated with a unique spatial

  5. Oxygen Activation by the Noncoupled Binuclear Copper Site in Peptidylglycine r-Hydroxylating Monooxygenase.

    E-Print Network [OSTI]

    Chen, Peng

    sites in hemocyanin, tyrosinase, and catechol oxidase, in O2 activation. 1. Introduction Cu proteinsII centers.4 Coupled binuclear Cu proteins include hemocyanin, tyrosinase, and catechol oxidase.2 The two Cu)), which is acti- vated for electrophilic attack on substrates (in tyrosinase).4 Noncoupled binuclear Cu

  6. Comparison of in-situ to ex-situ activities of bitumen-deactivated catalysts

    SciTech Connect (OSTI)

    Chu, K.S.; Dong, D.; Hanson, F.V.; Massoth, F.E. [Univ. of Utah, Salt Lake City, UT (United States). Dept. of Chemical and Fuels Engineering] [Univ. of Utah, Salt Lake City, UT (United States). Dept. of Chemical and Fuels Engineering

    1996-11-01T23:59:59.000Z

    Catalytic hydroprocessing is generally required to upgrade feedstocks derived from conventional petroleum, heavy oils, oil shales, and bitumen feedstocks prior to catalytic cracking and reforming operations. Catalyst deactivation runs were carried out in a flow reactor using bitumen and its maltene fraction as feeds in heptane solvent. Catalytic activity tests, using a mixture of model compounds, were performed to evaluate hydrogenation and C-N hydrogenolysis activities both directly after the aging run and again after the same aged catalyst had been posttreated by extraction with chloroform and resulfided. Two types of carbonaceous deposits were identified on the aged catalysts. One type, deposits left on the catalyst directly after the aging run, contained relatively large amounts of polymer-like material and caused significant losses in catalyst surface area. Catalytic activity was best related to residual, unblocked surface area and some poisoned sites. The second type, deposits remaining after extraction of the aged catalyst, was typical of conventional coke and did not block any pores. Subsequent activity tests showed activities were related to catalyst coke content.

  7. Cytotoxicity of lead on oligodendroglia, astroglia, and meningeal fibroblasts in culture: effects on viability and glycerolphosphate dehydrogenase activity

    E-Print Network [OSTI]

    Wu, Jo-Nan

    1986-01-01T23:59:59.000Z

    acid incorporation by meningeal fibroblasts. 10. GPDH activity of mixed glial cultures . 36 (units/culture dish). 37 11 ~ GPDH activity of mixed glial cultures (units/mg protein). 37 12. GPDH activity of oligodendroglial cultures (units.../culture dish) . . 39 13. GPDH activity of oligodendroglial cultures (units/mg protein). ~ . 39 INTRODUCTION Lead (Pb) poisoning is one of the earliest occu- pational diseases to be identified. In the United States, potential health hazards are created...

  8. Equipment Availability in the Home and School Environment: Its Relationship on Physical Activity in Children

    E-Print Network [OSTI]

    Montandon, Kristi

    2013-01-14T23:59:59.000Z

    activity behavior of children; availability of equipment is one of these factors. The overall purpose of this dissertation was to examine availability of equipment as an environmental influence on a child’s physical activity behavior. The two environments...

  9. Nicotine stimulates urokinase-type plasminogen activator receptor expression and cell invasiveness through mitogen-activated protein kinase and reactive oxygen species signaling in ECV304 endothelial cells

    SciTech Connect (OSTI)

    Khoi, Pham Ngoc; Park, Jung Sun; Kim, Nam Ho; Jung, Young Do, E-mail: ydjung@chonnam.ac.kr

    2012-03-01T23:59:59.000Z

    Urokinase-type plasminogen activator receptor (uPAR) expression is elevated during inflammation, tissue remodeling and in many human cancers. This study investigated the effect of nicotine, a major alkaloid in tobacco, on uPAR expression and cell invasiveness in ECV304 endothelial cells. Nicotine stimulated uPAR expression in a dose-dependent manner and activated extracellular signal-regulated kinases-1/2 (Erk-1/2), c-Jun amino-terminal kinase (JNK) and p38 mitogen activated protein kinase (MAPK). Specific inhibitors of MEK-1 (PD98059) and JNK (SP600125) inhibited the nicotine-induced uPAR expression, while the p38 MAPK inhibitor SB203580 did not. Expression vectors encoding dominant negative MEK-1 (pMCL-K97M) and JNK (TAM67) also prevented nicotine-induced uPAR promoter activity. The intracellular hydrogen peroxide (H{sub 2}O{sub 2}) content was increased by nicotine treatment. The antioxidant N-acetylcysteine prevented nicotine-activated production of reactive oxygen species (ROS) and uPAR expression. Furthermore, exogenous H{sub 2}O{sub 2} increased uPAR mRNA expression. Deleted and site-directed mutagenesis demonstrated the involvement of the binding sites of transcription factor nuclear factor-kappaB (NF-?B) and activator protein (AP)-1 in the nicotine-induced uPAR expression. Studies with expression vectors encoding mutated NF-?B signaling molecules and AP-1 decoy confirmed that NF-?B and AP-1 were essential for the nicotine-stimulated uPAR expression. MAPK (Erk-1/2 and JNK) and ROS functioned as upstream signaling molecules in the activation of AP-1 and NF-?B, respectively. In addition, ECV304 endothelial cells treated with nicotine displayed markedly enhanced invasiveness, which was partially abrogated by uPAR neutralizing antibodies. The data indicate that nicotine induces uPAR expression via the MAPK/AP-1 and ROS/NF-?B signaling pathways and, in turn, stimulates invasiveness in human ECV304 endothelial cells. -- Highlights: ? Endothelial cells treated with nicotine displayed enhanced invasiveness. ? Nicotine induces uPAR expression and, in turn, stimulates invasiveness. ? MAPK/AP-1 and ROS/NF-?B signals are involved in nicotine-induced uPAR.

  10. Strategies to Promote Active Learning in Math/Stat Discussion Sessions

    E-Print Network [OSTI]

    Maryland, Baltimore County, University of

    maxims for good teaching 3 What is active learning? 4 Why bother? 5 Types of active learning 6 Strategies 2006 6 / 14 #12;Types of active learning Blackboard work by TA with continuous, active input from (UMBC) Active Learning Strategies February 2006 7 / 14 #12;Types of active learning Step-by-step: Using

  11. On The Linearity of The Black Hole - Bulge Mass Relation in Active and in Nearby Galaxies

    E-Print Network [OSTI]

    Ari Laor

    2001-01-23T23:59:59.000Z

    Analysis of PG quasar observations suggests a nonlinear relation between the black hole mass, M_BH, and the bulge mass, M_bulge, although a linear relation, as proposed for nearby galaxies, cannot be ruled out. New M_BH values for nearby galaxies from Gebhardt et al., and L_bulge measurements for Seyfert 1 galaxies from Virani et al., are used here to obtain a more accurate value for the slope of the M_BH-M_bulge relation. The combined sample of 40 active and non-active galaxies suggests a significantly nonlinear relation, M_BH\\propto M_bulge^{1.53\\pm 0.14}. Further support for a nonlinear relation is provided by the slope of the M_BH-stellar velocity dispersion relation found recently, and by the low M_BH found in late type spiral galaxies. The mean M_BH/M_bulge ratio is therefore not a universal constant, but rather drops from ~0.5% in bright (M_V ~ -22) ellipticals, to ~0.05% in low luminosity (M_V ~ -18) bulges. Hubble Space Telescope determinations of M_BH in late type spirals, and of the bulge magnitude in narrow line Seyfert 1 galaxies (both predicted to have low M_BH), can further test the validity of the nonlinear M_BH-M_bulge relation.

  12. High-Resolution Modeling to Assess Tropical Cyclone Activity in Future Climate Regimes

    SciTech Connect (OSTI)

    Lackmann, Gary

    2013-06-10T23:59:59.000Z

    Applied research is proposed with the following objectives: (i) to determine the most likely level of tropical cyclone intensity and frequency in future climate regimes, (ii) to provide a quantitative measure of uncertainty in these predictions, and (iii) to improve understanding of the linkage between tropical cyclones and the planetary-scale circulation. Current mesoscale weather forecasting models, such as the Weather Research and Forecasting (WRF) model, are capable of simulating the full intensity of tropical cyclones (TC) with realistic structures. However, in order to accurately represent both the primary and secondary circulations in these systems, model simulations must be configured with sufficient resolution to explicitly represent convection (omitting the convective parameterization scheme). Most previous numerical studies of TC activity at seasonal and longer time scales have not utilized such explicit convection (EC) model runs. Here, we propose to employ the moving nest capability of WRF to optimally represent TC activity on a seasonal scale using a downscaling approach. The statistical results of a suite of these high-resolution TC simulations will yield a realistic representation of TC intensity on a seasonal basis, while at the same time allowing analysis of the feedback that TCs exert on the larger-scale climate system. Experiments will be driven with analyzed lateral boundary conditions for several recent Atlantic seasons, spanning a range of activity levels and TC track patterns. Results of the ensemble of WRF simulations will then be compared to analyzed TC data in order to determine the extent to which this modeling setup can reproduce recent levels of TC activity. Next, the boundary conditions (sea-surface temperature, tropopause height, and thermal/moisture profiles) from the recent seasons will be altered in a manner consistent with various future GCM/RCM scenarios, but that preserves the large-scale shear and incipient disturbance activity. This will allow (i) a direct comparison of future TC activity that could be expected for an active or inactive season in an altered climate regime, and (ii) a measure of the level of uncertainty and variability in TC activity resulting from different carbon emission scenarios.

  13. Active-Interrogation Measurements of Fast Neutrons from Induced Fission in Low-Enriched Uranium

    SciTech Connect (OSTI)

    J. L. Dolan; M. J. Marcath; M. Flaska; S. A. Pozzi; D. L. Chichester; A. Tomanin; P. Peerani

    2014-02-01T23:59:59.000Z

    A detection system was designed with MCNPX-PoliMi to measure induced-fission neutrons from U-235 and U-238 using active interrogation. Measurements were then performed with this system at the Joint Research Centre (JRC) in Ispra, Italy on low-enriched uranium samples. Liquid scintillators measured induced fission neutron to characterize the samples in terms of their uranium mass and enrichment. Results are presented to investigate and support the use of organic liquid scintillators with active interrogation techniques to characterize uranium containing materials.

  14. Continuous imaging of plasmon rulers in live cells reveals early-stage caspase-3 activation

    E-Print Network [OSTI]

    Craik, Charles S.

    Continuous imaging of plasmon rulers in live cells reveals early-stage caspase-3 activation of plasmon coupling in metal nanoparticles has shown great potential for the optical characterization of many biological processes. Recently, we have demonstrated the use of ``plasmon rulers'' to observe conformational

  15. Overexpression of Active Aurora-C Kinase Results in Cell Transformation and Tumour Formation

    E-Print Network [OSTI]

    Boyer, Edmond

    Overexpression of Active Aurora-C Kinase Results in Cell Transformation and Tumour Formation Jabbar, IFR140, Rennes, France Abstract Aurora kinases belong to a conserved family of serine/threonine kinases key regulators of cell cycle progression. Aurora-A and Aurora-B are expressed in somatic cells

  16. Heightened tropical cyclone activity in the North Atlantic: natural variability or

    E-Print Network [OSTI]

    Webster, Peter J.

    relatively stable regimes separated by sharp transitions. Each regime has seen 50% more cyclonesHeightened tropical cyclone activity in the North Atlantic: natural variability or climate trend cyclone and hurricane frequency over the past century in the North Atlantic Ocean have occurred as three

  17. Hydrogen bond dynamics in the active site of photoactive yellow protein

    E-Print Network [OSTI]

    Herschlag, Dan

    Hydrogen bond dynamics in the active site of photoactive yellow protein Paul A. Sigala, Mark A for review February 5, 2009) Hydrogen bonds play major roles in biological structure and function. Nonetheless, hydrogen-bonded protons are not typically observed by X-ray crystallography, and most structural

  18. Catalytically active nickel ^110 surfaces in growth of carbon tubular structures

    E-Print Network [OSTI]

    Wang, Zhong L.

    Catalytically active nickel ^110 surfaces in growth of carbon tubular structures M. H. Kuang and Z of Sciences, Beijing 100083, China Received 19 October 1999; accepted for publication 11 January 2000 Recent interest in the growth of aligned carbon nanotube films using transition metal catalysts has led

  19. Mastoparan Activates Calcium Spiking Analogous to Nod Factor-Induced Responses in Medicago truncatula

    E-Print Network [OSTI]

    Downie, J. Allan

    PERCEPTION and DMI2 and in the putative cation channel DMI1, which are all required for Nod factor induction phosphate (NAADP), cADP-Rib (cADPR), and calcium itself can function as secondary messengers directly or indirectly modifying calcium channels to activate calcium release (Sanders et al., 2002). In ani- mal cells

  20. Activation of ERK and JNK signaling pathways by mycotoxin citrinin in human cells

    SciTech Connect (OSTI)

    Chang, C.-H.; Yu, F.-Y.; Wang, L.-T.; Lin, Y.-S. [Department of Biomedical Sciences, Chung Shan Medical University, No. 110, Sec. 1, Chien-Kuo N. Rd., Taichung 402, Taiwan (China); Liu, B.-H. [Department of Biomedical Sciences, Chung Shan Medical University, No. 110, Sec. 1, Chien-Kuo N. Rd., Taichung 402, Taiwan (China)], E-mail: bingliu@csmu.edu.tw

    2009-06-15T23:59:59.000Z

    Mycotoxin citrinin (CTN) is commonly found in foods and feeds that are contaminated/inoculated with Penicillium, Aspergillus and Monascus species. The exposure of human embryonic kidney (HEK293) and HeLa cells to CTN resulted in a dose-dependent increase in the phosphorylation of two major mitogen-activated protein kinases (MAPKs), ERK1/2 and JNK. In HEK293 cultures, the administering of CTN increased both the mRNA and protein levels of egr-1, c-fos and c-jun genes; additionally, the ERK1/2 pathway contributed to the upregulation of Egr-1 and c-Fos protein expression. CTN treatment also induced the transcription activity of Egr-1 and AP-1 proteins, as evidenced by luciferase reporter assays. Bioinformatic analyses indicated two genes Gadd45{beta} and MMP3 have Egr-1 and AP-1 response elements in their promoters, respectively. Furthermore, co-exposure of HEK293 cells to CTN and MAPK pathway inhibitors demonstrated that CTN increased the levels of Gadd45{beta} mRNA through ERK1/2 signaling pathway and up-regulated the MMP3 transcripts majorly via JNK pathway. Finally, CTN-triggered caspase 3 activity was significantly reduced in the presence of MAPK inhibitors. Our results suggest that CTN positively regulates ERK1/2 and JNK pathways as well as their downstream effectors in human cells; activated MAPK pathways are also involved in CTN-induced apoptosis.

  1. Decay of the cosmological constant: Equivalence of quantum tunneling and thermal activation in two spacetime dimensions

    SciTech Connect (OSTI)

    Gomberoff, Andres; Henneaux, Marc; Teitelboim, Claudio [Centro de Estudios Cientificos (CECS), Valdivia (Chile); Physique Theorique et Mathematique, Universite Libre de Bruxelles and International Solvay Institutes, ULB Campus Plaine C.P. 231, B-1050 Brussels (Belgium); Centro de Estudios Cientificos (CECS), Valdivia (Chile); Centro de Estudios Cientificos (CECS), Valdivia (Chile)

    2005-03-15T23:59:59.000Z

    We study the decay of the cosmological constant in two spacetime dimensions through production of pairs. We show that the same nucleation process looks as quantum-mechanical tunneling (instanton) to one Killing observer and as thermal activation (thermalon) to another. Thus, we find another striking example of the deep interplay between gravity, thermodynamics and quantum mechanics which becomes apparent in presence of horizons.

  2. Active and Passive Learning in Agent-based Financial Markets Blake LeBaron

    E-Print Network [OSTI]

    Tesfatsion, Leigh

    markets contain some form of both these types of learning. From what we know so far the dynamics of eachActive and Passive Learning in Agent-based Financial Markets Blake LeBaron International Business of learning which are present in most agent-based financial markets. First, passive learning refers to a form

  3. Bass Hepcidin Synthesis, Solution Structure, Antimicrobial Activities and Synergism, and in Vivo Hepatic Response to

    E-Print Network [OSTI]

    Nizet, Victor

    in the antimicrobial defenses of bass and that its functions are potentially conserved between fish and humanBass Hepcidin Synthesis, Solution Structure, Antimicrobial Activities and Synergism, and in Vivo, Pennsylvania 19406 Bass hepcidin was purified from the gill of hybrid striped bass (Morone chrysops Morone

  4. Ambient induced degradation and chemically activated recovery in copper phthalocyanine thin film transistors

    E-Print Network [OSTI]

    Kummel, Andrew C.

    Ambient induced degradation and chemically activated recovery in copper phthalocyanine thin film 2009 The electrical degradation aging of copper phthalocyanine CuPc organic thin film transistors OTFTs layer.6,17,18 A systematic approach to iso- lating the cause of device degradation "aging" in copper

  5. FOOD, ACTIVITY, AND HABITAT OF THREE "PICKERTYPE" MICROCARNIVOROUS FISHES IN THE KELP FORESTS OFF

    E-Print Network [OSTI]

    FOOD, ACTIVITY, AND HABITAT OF THREE "PICKER·TYPE" MICROCARNIVOROUS FISHES IN THE KELP FORESTS OFF, and habitat preference were compared between the kelp perch, Brachyistius frenatus; the sefiorita, Oxyjulis californica; and the white seaperch, Phanerodonfurcatus, all of which co-occur in areas of reef and kelp off

  6. The Detection of Thyroid Receptor-Mediated Transcriptional Activity in Treated Peter Littlehat, Jr.

    E-Print Network [OSTI]

    Fay, Noah

    The Detection of Thyroid Receptor-Mediated Transcriptional Activity in Treated Wastewater by Peter) and other trace organic compounds that are released to the environment in treated domestic wastewaters of the thyroid hormone compounds under the two conditions, (ii) screen and compare the responsiveness of treated

  7. Effect of optical pumping on the refractive index and temperature in the core of active fibre

    SciTech Connect (OSTI)

    Gainov, V V; Ryabushkin, Oleg A [V.A.Kotel'nikov Institute of Radio Engineering and Electronics, Fryazino Branch, Russian Academy of Sciences, Fryazino, Moscow Region (Russian Federation)

    2011-09-30T23:59:59.000Z

    This paper examines the refractive index change (RIC) induced in the core of Yb{sup 3+}-doped active silica fibres by pulsed pumping. RIC kinetic measurements with a Mach - Zehnder interferometer make it possible to separately assess the contributions of the electronic and thermal mechanisms to the RIC and evaluate temperature nonuniformities in the fibre.

  8. Charge-Separation in Uranium Diazomethane Complexes Leading to C-H Activation and Chemical Transformation

    E-Print Network [OSTI]

    Meyer, Karsten

    coordination and organometallic chemistry.1-3 The covalency in uranium ligand bonds is weaker thanCharge-Separation in Uranium Diazomethane Complexes Leading to C-H Activation and ChemicalVersity of California, San Diego, Department of Chemistry, 9500 Gilman DriVe, La Jolla, California 92093, and Uni

  9. Antiremodeling Agents Influence Osteoblast Activity Differently in Modeling and Remodeling Sites of Canine Rib

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    effects on osteo- blast activity in the canine rib and (2) this effect depends on whether modeling reduce bone loss in part through direct actions on osteoclasts. Their effects on osteoblasts and bone treatments (+108 to +175%, P effect on MAR at either the en- docortical

  10. INTERNATIONAL ACTIVITIES Preamble: Beans (Phaseolus vulgaris) originated in Latin America and are widely grown at

    E-Print Network [OSTI]

    INTERNATIONAL ACTIVITIES Preamble: Beans (Phaseolus vulgaris) originated in Latin America and are widely grown at mid- to higher elevations today from Chile to Canada. Brazil is the world's leading bean their importance as a food security crop in many Latin American countries, bean production has been relegated

  11. Verifiable Active Safety for Automotive Cyber-Physical Systems with Humans in the Loop

    E-Print Network [OSTI]

    Rajkumar, Ragunathan "Raj"

    Verifiable Active Safety for Automotive Cyber-Physical Systems with Humans in the Loop Francesco-6925 A recent trend in the automotive industry is the rapid inclusion of electronics, computers and controls that focus entirely on improved functionality and overall system robustness. This makes the automotive sector

  12. Health Monitoring in an Agent-Based Smart Home by Activity Prediction

    E-Print Network [OSTI]

    Cook, Diane J.

    Health Monitoring in an Agent-Based Smart Home by Activity Prediction Sajal K. Das and Diane J objective of this paper is to investigate techniques for using agent-based smart home technologies-based smart home project funded by NSF. 1 Introduction and Motivation We live in an increasingly connected

  13. CONTROL OF AN IDEAL ACTIVATED SLUDGE PROCESS IN WASTEWATER TREATMENT VIA AN ODE-PDE MODEL

    E-Print Network [OSTI]

    Diehl, Stefan

    CONTROL OF AN IDEAL ACTIVATED SLUDGE PROCESS IN WASTEWATER TREATMENT VIA AN ODE-PDE MODEL STEFAN treatment plants, consists basically of a biological reactor followed by a sedi- mentation tank, which has. 1. Introduction The need for efficient wastewater treatment plants in terms of low effluent con

  14. Rapid, Active Hair Bundle Movements in Hair Cells from the Bullfrog's Sacculus

    E-Print Network [OSTI]

    Hudspeth, A. James

    Rapid, Active Hair Bundle Movements in Hair Cells from the Bullfrog's Sacculus Michael E. Benser Neuroscience, The Rockefeller University, New York, New York 10021 Hair bundles, the mechanically sensitive organelles of hair cells in the auditory and vestibular systems, are elastic structures that are deflected

  15. Methods of communicating activities in pollution abatement by five hundred major industrial corporations in the United States

    E-Print Network [OSTI]

    Quinn, Christine Ann

    1973-01-01T23:59:59.000Z

    METHODS OF COMMUNICATING ACTIVITIES IN POLLUTION ABATEMENT BY FIVE HUNDRED MAJOR INDUSTRIAL CORPORATIONS IN THE UNITED STATES A Thesis by CHRISTINE ANN OUINN Submitted to the Graduate College of Texas A&M University in partial fulfillment... of the requirement for the degree of MASTER OF SCIENCE August 1973 Major Subject: Educational Administration (Public Relations) METHODS OF COMMUNICATING ACTIVITIES IN POLLUTION ABATEMENT BY FIVE HUNDRED MAJOR INDUSTRIAL CORPORATIONS IN THE UNITED STATES A...

  16. Determination of oxygen in molten alkali halide salts by proton activation analysis

    SciTech Connect (OSTI)

    Wai, C.M.; Dysart, M.E.

    1986-12-01T23:59:59.000Z

    The authors have recently used a lanthanum fluoride precipitation method to separate /sup 18/F produced from proton activation of /sup 18/O in alkali chloride and fluoride salts. The procedure was developed for studying dissolved oxide species in alkali halide melts. Determination of oxygen in these systems is important for research in batteries and in extractive metallurgy utilizing molten salts as solvents. The details are given oxygen determination in alkali chloride and fluoride systems.

  17. Time-course comparison of xenobiotic activators of CAR and PPAR{alpha} in mouse liver

    SciTech Connect (OSTI)

    Ross, Pamela K. [Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC (United States); Woods, Courtney G. [Hamner Institutes for Health Sciences, Research Triangle Park, NC (United States); ExxonMobil Biomedical Sciences, Annandale, NJ (United States); Bradford, Blair U.; Kosyk, Oksana; Gatti, Daniel M. [Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC (United States); Cunningham, Michael L. [National Institute for Environmental Health Sciences, Research Triangle Park, NC (United States); Rusyn, Ivan [Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC (United States)], E-mail: iir@unc.edu

    2009-03-01T23:59:59.000Z

    Constitutive androstane receptor (CAR) and peroxisome proliferator activated receptor (PPAR){alpha} are transcription factors known to be primary mediators of liver effects, including carcinogenesis, by phenobarbital-like compounds and peroxisome proliferators, respectively, in rodents. Many similarities exist in the phenotypes elicited by these two classes of agents in rodent liver, and we hypothesized that the initial transcriptional responses to the xenobiotic activators of CAR and PPAR{alpha} will exhibit distinct patterns, but at later time-points these biological pathways will converge. In order to capture the global transcriptional changes that result from activation of these nuclear receptors over a time-course in the mouse liver, microarray technology was used. First, differences in basal expression of liver genes between C57Bl/6J wild-type and Car-null mice were examined and 14 significantly differentially expressed genes were identified. Next, mice were treated with phenobarbital (100 mg/kg by gavage for 24 h, or 0.085% w/w diet for 7 or 28 days), and liver gene expression changes with regards to both time and treatment were identified. While several pathways related to cellular proliferation and metabolism were affected by phenobarbital in wild-type mice, no significant changes in gene expression were found over time in the Car-nulls. Next, we determined commonalities and differences in the temporal response to phenobarbital and WY-14,643, a prototypical activator of PPAR {alpha}. Gene expression signatures from livers of wild-type mice C57Bl6/J mice treated with PB or WY-14,643 were compared. Similar pathways were affected by both compounds; however, considerable time-related differences were present. This study establishes common gene expression fingerprints of exposure to activators of CAR and PPAR{alpha} in rodent liver and demonstrates that despite similar phenotypic changes, molecular pathways differ between classes of chemical carcinogens.

  18. Filament Activation in Response to Magnetic Flux Emergence and Cancellation in Filament Channels

    E-Print Network [OSTI]

    Li, Ting; Ji, Haisheng

    2015-01-01T23:59:59.000Z

    We make a comparative analysis for two filaments that showed quite different activation in response to the flux emergence within the filament channels. The observations from the Solar Dynamics Observatory (SDO) and Global Oscillation Network Group (GONG) are carried out to analyze the two filaments on 2013 August 17-20 and September 29. The first event showed that the main body of the filament was separated into two parts when an active region (AR) emerged with a maximum magnetic flux of about 6.4*10^21 Mx underlying the filament. The close neighborhood and common direction of the bright threads in the filament and the open AR fan loops suggest similar magnetic connectivity of these two flux systems. The equilibrium of the filament was not destroyed within 3 days after the start of the emergence of the AR. To our knowledge, similar observations have never been reported before. In the second event, the emerging flux occurred nearby a barb of the filament with a maximum magnetic flux of 4.2*10^20 Mx, about one ...

  19. Chaotic mean wind in turbulent thermal convection and long-term correlations in solar activity

    E-Print Network [OSTI]

    A. Bershadskii

    2009-12-25T23:59:59.000Z

    It is shown that correlation function of the mean wind velocity in a turbulent thermal convection (Rayleigh number $Ra \\sim 10^{11}$) exhibits exponential decay with a very long correlation time, while corresponding largest Lyapunov exponent is certainly positive. These results together with the reconstructed phase portrait indicate presence of a chaotic component in the examined mean wind. Telegraph approximation is also used to study relative contribution of the chaotic and stochastic components to the mean wind fluctuations and an equilibrium between these components has been studied. Since solar activity is based on the thermal convection processes, it is reasoned that the observed solar activity long-term correlations can be an imprint of the mean wind chaotic properties. In particular, correlation function of the daily sunspots number exhibits exponential decay with a very long correlation time and corresponding largest Lyapunov exponent is certainly positive, also relative contribution of the chaotic and stochastic components follows the same pattern as for the convection mean wind.

  20. In-growth of an electrically active defect in high-purity silicon after proton irradiation

    SciTech Connect (OSTI)

    Nylandsted Larsen, A.; Juul Pedersen, H.; Christian Petersen, M. [Department of Physics and Astronomy, and Interdisciplinary Nanoscience Center, Aarhus University, Aarhus (Denmark)] [Department of Physics and Astronomy, and Interdisciplinary Nanoscience Center, Aarhus University, Aarhus (Denmark); Privitera, V. [CNR-IMM, Institute of Microelectronics and Microsystems, Catania (Italy)] [CNR-IMM, Institute of Microelectronics and Microsystems, Catania (Italy); Gurimskaya, Y.; Mesli, A. [IM2NP, CNRS (UMR 7334) and Université Aix-Marseille, 13397 Marseille Cedex 20 (France)] [IM2NP, CNRS (UMR 7334) and Université Aix-Marseille, 13397 Marseille Cedex 20 (France)

    2013-12-14T23:59:59.000Z

    Defect-related energy levels in the lower half of the band gap of silicon have been studied with transient-capacitance techniques in high-purity, carbon and oxygen lean, plasma-enhanced chemical-vapor deposition grown, n-and p-type silicon layers after 2-MeV proton irradiations at temperatures at or just below room temperature. The in-growth of a distinct line in deep-level transient spectroscopy spectra, corresponding to a level in the band gap at E{sub V} + 0.357 eV where E{sub V} is the energy of the valence band edge, takes place for anneal temperatures at around room temperature with an activation energy of 0.95 ± 0.08 eV. The line disappears at an anneal temperature of around 450 K. The corresponding defect is demonstrated not to contain boron, carbon, oxygen, or phosphorus. Possible defect candidates are discussed.