National Library of Energy BETA

Sample records for accelerator mass spectrometry

  1. Symposium on accelerator mass spectrometry

    SciTech Connect (OSTI)

    1981-01-01

    The area of accelerator mass spectrometry has expanded considerably over the past few years and established itself as an independent and interdisciplinary research field. Three years have passed since the first meeting was held at Rochester. A Symposium on Accelerator Mass Spectrometry was held at Argonne on May 11-13, 1981. In attendance were 96 scientists of whom 26 were from outside the United States. The present proceedings document the program and excitement of the field. Papers are arranged according to the original program. A few papers not presented at the meeting have been added to complete the information on the status of accelerator mass spectrometry. Individual papers were prepared separately for the data base.

  2. Early Days of Accelerator Mass Spectrometry

    DOE R&D Accomplishments [OSTI]

    Alvarez, L. W.

    1981-05-01

    Alvarez reviews his role in the development of the tandem Van de Graaff accelerator and the technique of accelerator mass spectrometry as a technique for isotope dating. (GHT)

  3. Accelerator mass spectrometry program at the University of Washington

    SciTech Connect (OSTI)

    Farwell, G.W.; Leach, D.D.; Grootes, P.M.; Schmidt, F.H.

    1984-04-10

    The University uses an FN-Tandem for /sup 14/C and /sup 10/Be measurements. Three main problems for accelerator-mass-spectrometry are normalization, stability, and sample preparation. The approach to these problems is discussed. (GHT)

  4. Small system for tritium accelerator mass spectrometry

    DOE Patents [OSTI]

    Roberts, M.L.; Davis, J.C.

    1993-02-23

    Apparatus for ionizing and accelerating a sample containing isotopes of hydrogen and detecting the ratios of hydrogen isotopes contained in the sample is disclosed. An ion source generates a substantially linear ion beam including ions of tritium from the sample. A radio-frequency quadrupole accelerator is directly coupled to and axially aligned with the source at an angle of substantially zero degrees. The accelerator accelerates species of the sample having different mass to different energy levels along the same axis as the ion beam. A spectrometer is used to detect the concentration of tritium ions in the sample. In one form of the invention, an energy loss spectrometer is used which includes a foil to block the passage of hydrogen, deuterium and [sup 3]He ions, and a surface barrier or scintillation detector to detect the concentration of tritium ions. In another form of the invention, a combined momentum/energy loss spectrometer is used which includes a magnet to separate the ion beams, with Faraday cups to measure the hydrogen and deuterium and a surface barrier or scintillation detector for the tritium ions.

  5. Transition of Iodine Analysis to Accelerator Mass Spectrometry

    SciTech Connect (OSTI)

    M. L. Adamic; J. E. Olson; D. D. Jenson; J. G. Eisenmenger; M. G. Watrous

    2012-09-01

    This NA 22 funded research project investigated the transition of iodine isotopic analyses from thermal ionization mass spectrometry (TIMS) to an accelerator mass spectrometry (AMS) system. Previous work (Fiscal Year 2010) had demonstrated comparable data from TIMS and AMS. With AMS providing comparable data with improved background levels and vastly superior sample throughput, improvement in the sample extraction from environmental sample matrices was needed to bring sample preparation throughput closer to the operation level of the instrument. Previous research used an extraction chemistry that was not optimized for yield or refined for reduced labor to prove the principle. This research was done to find an extraction with better yield using less labor per sample to produce a sample ready for the AMS instrument. An extraction method using tetramethyl ammonium hydroxide (TMAH) was developed for removal of iodine species from high volume air filters. The TMAH with gentle heating was superior to the following three extraction methods: ammonium hydroxide aided by sonication, acidic and basic extraction aided by microwave, and ethanol mixed with sodium hydroxide. Taking the iodine from the extraction solvent to being ready for AMS analysis was accomplished by a direct precipitation, as well as, using silver wool to harvest the iodine from the TMAH. Portions of the same filters processed in FY 2010 were processed again with the improved extraction scheme followed by successful analysis by AMS at the Swiss Federal Institute of Technology. The data favorably matched the data obtained in 2010. The time required for analysis has been reduced over the aqueous extraction/AMS approach developed in FY 2010. For a hypothetical batch of 30 samples, the AMS methodology is about 10 times faster than the traditional gas phase chemistry and TIMS analysis. As an additional benefit, background levels for the AMS method are about 1000 times lower than TIMS. This results from the fundamental mechanisms of ionization in the AMS system and which produces a beneficial cleanup of molecular interferences. Continued clean operation of the extraction process was demonstrated through blank analysis included with all sample sets analyzed. INL work showed improvement on the first year’s demonstration of AMS vs. TIMS. An improved extraction of high volume air filters followed by isotopic analysis by AMS, can be used successfully to make iodine measurements with results comparable to those obtained by filter combustion and TIMS analysis. More progress on the conversion from an extract solution to an AMS sample ready for analysis is still needed. Although the preparation scheme through AMS is already at a higher performing thoughput than TIMS, the chemical preparation cannot match the instrument capability for number of samples per day without further development.

  6. Technological advances in the University of Washington accelerator mass spectrometry system

    SciTech Connect (OSTI)

    Farwell, G.W.; Grootes, P.M.; Leach, D.D.; Schmidt, F.H.

    1983-01-01

    During the past year we have continued to work toward greater stability and flexibility in nearly all elements of our accelerator mass spectrometry (AMS) system, which is based upon an FN tandem Van de Graaff accelerator, and have carried out measurements of /sup 14/C//sup 12/C and /sup 10/Be//sup 9/Be isotopic abundance ratios in natural samples. The principal recent developments and improvements in the accelerator system and in our sample preparation techniques for carbon beryllium are discussed, and the results of a study of /sup 10/Be cross-contamination of beryllium samples in the sputter ion source are presented.

  7. Accelerator Mass Spectrometry | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Accelerator Mass Spectrometry at ANL and ORNL Nuclear Physics (NP) NP Home About Research Facilities Science Highlights Benefits of NP Applications of Nuclear Science Applications of Nuclear Science Archives Small Business Innovation / Technology Transfer Funding Opportunities Nuclear Science Advisory Committee (NSAC) Community Resources Contact Information Nuclear Physics U.S. Department of Energy SC-26/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3613 F:

  8. Analytical Validation of Accelerator Mass Spectrometry for Pharmaceutical Development: the Measurement of Carbon-14 Isotope Ratio.

    SciTech Connect (OSTI)

    Keck, B D; Ognibene, T; Vogel, J S

    2010-02-05

    Accelerator mass spectrometry (AMS) is an isotope based measurement technology that utilizes carbon-14 labeled compounds in the pharmaceutical development process to measure compounds at very low concentrations, empowers microdosing as an investigational tool, and extends the utility of {sup 14}C labeled compounds to dramatically lower levels. It is a form of isotope ratio mass spectrometry that can provide either measurements of total compound equivalents or, when coupled to separation technology such as chromatography, quantitation of specific compounds. The properties of AMS as a measurement technique are investigated here, and the parameters of method validation are shown. AMS, independent of any separation technique to which it may be coupled, is shown to be accurate, linear, precise, and robust. As the sensitivity and universality of AMS is constantly being explored and expanded, this work underpins many areas of pharmaceutical development including drug metabolism as well as absorption, distribution and excretion of pharmaceutical compounds as a fundamental step in drug development. The validation parameters for pharmaceutical analyses were examined for the accelerator mass spectrometry measurement of {sup 14}C/C ratio, independent of chemical separation procedures. The isotope ratio measurement was specific (owing to the {sup 14}C label), stable across samples storage conditions for at least one year, linear over 4 orders of magnitude with an analytical range from one tenth Modern to at least 2000 Modern (instrument specific). Further, accuracy was excellent between 1 and 3 percent while precision expressed as coefficient of variation is between 1 and 6% determined primarily by radiocarbon content and the time spent analyzing a sample. Sensitivity, expressed as LOD and LLOQ was 1 and 10 attomoles of carbon-14 (which can be expressed as compound equivalents) and for a typical small molecule labeled at 10% incorporated with {sup 14}C corresponds to 30 fg equivalents. AMS provides an sensitive, accurate and precise method of measuring drug compounds in biological matrices.

  9. Interface for the rapid analysis of liquid samples by accelerator mass spectrometry

    DOE Patents [OSTI]

    Turteltaub, Kenneth; Ognibene, Ted; Thomas, Avi; Daley, Paul F; Salazar Quintero, Gary A; Bench, Graham

    2014-02-04

    An interface for the analysis of liquid sample having carbon content by an accelerator mass spectrometer including a wire, defects on the wire, a system for moving the wire, a droplet maker for producing droplets of the liquid sample and placing the droplets of the liquid sample on the wire in the defects, a system that converts the carbon content of the droplets of the liquid sample to carbon dioxide gas in a helium stream, and a gas-accepting ion source connected to the accelerator mass spectrometer that receives the carbon dioxide gas of the sample in a helium stream and introduces the carbon dioxide gas of the sample into the accelerator mass spectrometer.

  10. Accelerator mass spectrometry facility at the University of Washington: current status, and an application to the /sup 14/C profile of a tree ring

    SciTech Connect (OSTI)

    Farwell, G.W.; Grootes, P.M.; Leach, D.D.; Schmidt, F.H.

    1984-01-01

    The University of Washington Model FN Tandem accelerator (1) is used for Accelerator Mass Spectrometry (AMS) of /sup 10/Be and /sup 14/C. This paper describes our basic system, our methods for rare-isotope normalization, final ion detection, and sample preparation, and the general problem of adapting an existing accelerator to meet the stringent stability requirements of precision AMS measurements while retaining human and technical compatibility with other users and uses of the accelerator. Recent preliminary data obtained on /sup 14/C in thin sequential sections of a single Sitka spruce tree ring (1963) are presented.

  11. Single event mass spectrometry

    DOE Patents [OSTI]

    Conzemius, Robert J. (Ames, IA)

    1990-01-16

    A means and method for single event time of flight mass spectrometry for analysis of specimen materials. The method of the invention includes pulsing an ion source imposing at least one pulsed ion onto the specimen to produce a corresponding emission of at least one electrically charged particle. The emitted particle is then dissociated into a charged ion component and an uncharged neutral component. The ion and neutral components are then detected. The time of flight of the components are recorded and can be used to analyze the predecessor of the components, and therefore the specimen material. When more than one ion particle is emitted from the specimen per single ion impact, the single event time of flight mass spectrometer described here furnis This invention was made with Government support under Contract No. W-7405-ENG82 awarded by the Department of Energy. The Government has certain rights in the invention.

  12. Linear electric field mass spectrometry

    DOE Patents [OSTI]

    McComas, David J. (Los Alamos, NM); Nordholt, Jane E. (Los Alamos, NM)

    1992-01-01

    A mass spectrometer and methods for mass spectrometry. The apparatus is compact and of low weight and has a low power requirement, making it suitable for use on a space satellite and as a portable detector for the presence of substances. High mass resolution measurements are made by timing ions moving through a gridless cylindrically symmetric linear electric field.

  13. Linear electric field mass spectrometry

    DOE Patents [OSTI]

    McComas, D.J.; Nordholt, J.E.

    1992-12-01

    A mass spectrometer and methods for mass spectrometry are described. The apparatus is compact and of low weight and has a low power requirement, making it suitable for use on a space satellite and as a portable detector for the presence of substances. High mass resolution measurements are made by timing ions moving through a gridless cylindrically symmetric linear electric field. 8 figs.

  14. Mass spectrometry for biomarker development

    SciTech Connect (OSTI)

    Wu, Chaochao; Liu, Tao; Baker, Erin Shammel; Rodland, Karin D.; Smith, Richard D.

    2015-06-19

    Biomarkers potentially play a crucial role in early disease diagnosis, prognosis and targeted therapy. In the past decade, mass spectrometry based proteomics has become increasingly important in biomarker development due to large advances in technology and associated methods. This chapter mainly focuses on the application of broad (e.g. shotgun) proteomics in biomarker discovery and the utility of targeted proteomics in biomarker verification and validation. A range of mass spectrometry methodologies are discussed emphasizing their efficacy in the different stages in biomarker development, with a particular emphasis on blood biomarker development.

  15. Electrospray Ionization Mass Spectrometry

    SciTech Connect (OSTI)

    Kelly, Ryan T.; Marginean, Ioan; Tang, Keqi

    2014-06-13

    Electrospray Ionization (ESI) is a process whereby gas phase ions are created from molecules in solution. As a solution exits a narrow tube in the presence of a strong electric field, an aerosol of charged droplets are is formed that produces gas phase ions as they it desolvates. ESI-MS comprises the creation of ions by ESI and the determination of their mass to charge ratio (m/z) by MS.

  16. Electrophoresis-mass spectrometry probe

    DOE Patents [OSTI]

    Andresen, Brian D. (Pleasanton, CA); Fought, Eric R. (Livermore, CA)

    1987-01-01

    The invention involves a new technique for the separation of complex mixtures of chemicals, which utilizes a unique interface probe for conventional mass spectrometers which allows the electrophoretically separated compounds to be analyzed in real-time by a mass spectrometer. This new chemical analysis interface, which couples electrophoresis with mass spectrometry, allows complex mixtures to be analyzed very rapidly, with much greater specificity, and with greater sensitivity. The interface or probe provides a means whereby large and/or polar molecules in complex mixtures to be completely characterized. The preferred embodiment of the probe utilizes a double capillary tip which allows the probe tip to be continually wetted by the buffer, which provides for increased heat dissipation, and results in a continually operating interface which is more durable and electronically stable than the illustrated single capillary tip probe interface.

  17. Electrophoresis-mass spectrometry probe

    DOE Patents [OSTI]

    Andresen, B.D.; Fought, E.R.

    1987-11-10

    The invention involves a new technique for the separation of complex mixtures of chemicals, which utilizes a unique interface probe for conventional mass spectrometers which allows the electrophoretically separated compounds to be analyzed in real-time by a mass spectrometer. This new chemical analysis interface, which couples electrophoresis with mass spectrometry, allows complex mixtures to be analyzed very rapidly, with much greater specificity, and with greater sensitivity. The interface or probe provides a means whereby large and/or polar molecules in complex mixtures to be completely characterized. The preferred embodiment of the probe utilizes a double capillary tip which allows the probe tip to be continually wetted by the buffer, which provides for increased heat dissipation, and results in a continually operating interface which is more durable and electronically stable than the illustrated single capillary tip probe interface. 8 figs.

  18. Methods for recalibration of mass spectrometry data

    DOE Patents [OSTI]

    Tolmachev, Aleksey V. (Richland, WA); Smith, Richard D. (Richland, WA)

    2009-03-03

    Disclosed are methods for recalibrating mass spectrometry data that provide improvement in both mass accuracy and precision by adjusting for experimental variance in parameters that have a substantial impact on mass measurement accuracy. Optimal coefficients are determined using correlated pairs of mass values compiled by matching sets of measured and putative mass values that minimize overall effective mass error and mass error spread. Coefficients are subsequently used to correct mass values for peaks detected in the measured dataset, providing recalibration thereof. Sub-ppm mass measurement accuracy has been demonstrated on a complex fungal proteome after recalibration, providing improved confidence for peptide identifications.

  19. Capillary electrophoresis electrospray ionization mass spectrometry interface

    DOE Patents [OSTI]

    Smith, Richard D. (Richland, WA); Severs, Joanne C. (Hayward, CA)

    1999-01-01

    The present invention is an interface between a capillary electrophoresis separation capillary end and an electrospray ionization mass spectrometry emitter capillary end, for transporting an anolyte sample from a capillary electrophoresis separation capillary to a electrospray ionization mass spectrometry emitter capillary. The interface of the present invention has: (a) a charge transfer fitting enclosing both of the capillary electrophoresis capillary end and the electrospray ionization mass spectrometry emitter capillary end; (b) a reservoir containing an electrolyte surrounding the charge transfer fitting; and (c) an electrode immersed into the electrolyte, the electrode closing a capillary electrophoresis circuit and providing charge transfer across the charge transfer fitting while avoiding substantial bulk fluid transfer across the charge transfer fitting. Advantages of the present invention have been demonstrated as effective in providing high sensitivity and efficient analyses.

  20. Nanostructure-initiator mass spectrometry biometrics

    DOE Patents [OSTI]

    Leclerc, Marion; Bowen, Benjamin; Northen, Trent

    2015-09-08

    Several embodiments described herein are drawn to methods of identifying an analyte on a subject's skin, methods of generating a fingerprint, methods of determining a physiological change in a subject, methods of diagnosing health status of a subject, and assay systems for detecting an analyte and generating a fingerprint, by nanostructure-initiator mass spectrometry (NIMS).

  1. Monolithic multinozzle emitters for nanoelectrospray mass spectrometry

    DOE Patents [OSTI]

    Wang, Daojing (Daly City, CA); Yang, Peidong (Kensington, CA); Kim, Woong (Seoul, KR); Fan, Rong (Pasadena, CA)

    2011-09-20

    Novel and significantly simplified procedures for fabrication of fully integrated nanoelectrospray emitters have been described. For nanofabricated monolithic multinozzle emitters (NM.sup.2 emitters), a bottom up approach using silicon nanowires on a silicon sliver is used. For microfabricated monolithic multinozzle emitters (M.sup.3 emitters), a top down approach using MEMS techniques on silicon wafers is used. The emitters have performance comparable to that of commercially-available silica capillary emitters for nanoelectrospray mass spectrometry.

  2. CAMS Center for Accelerator Mass Spectrometry

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of the art instrumentation, to develop and apply unique, ultra-sensitive isotope ratio measurement and ion beam analytical techniques to address a broad spectrum of scientific...

  3. Automated Surface Sampling Probe for Mass Spectrometry - Energy Innovation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Portal Advanced Materials Advanced Materials Find More Like This Return to Search Automated Surface Sampling Probe for Mass Spectrometry Mass Spectrometry Imaging for Drug Discovery and Pharmaceutical Research Oak Ridge National Laboratory Contact ORNL About This Technology Technology Marketing SummaryDr. Gary Van Berkel and colleagues have developed a liquid microjunction surface sampling probe (LMJ?SSP). The LMJ?SSP provides mass spectrometry with a simple and efficient ambient surface

  4. Method Development and Application of Mass Spectrometry Imaging...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mass spectrometry imaging is making a significant impact in the fields of pathology, medicine and biology. It provides a unique capability to simultaneously measure,...

  5. Mass Spectrometry imaging of plant metabolites | The Ames Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    We are developing and applying mass spectrometry imaging technique to understand plant metabolic biology down to cellular and eventually subcellular level high-spatial...

  6. A new detector for mass spectrometry: Direct detection of low...

    Office of Scientific and Technical Information (OSTI)

    A new detector for mass spectrometry: Direct detection of low energy ions using a ... Subject: 46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; CRYSTALS; ION ...

  7. Giga-Dalton Mass Spectrometry - Energy Innovation Portal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Biomass and Biofuels Biomass and Biofuels Advanced Materials Advanced Materials Find More Like This Return to Search Giga-Dalton Mass Spectrometry Major leap forward for Mass Spectrometry Applications to Life Sciences Oak Ridge National Laboratory Contact ORNL About This Technology Technology Marketing SummaryCurrent techniques to study large bio?molecules using mass spectrometer require fragmentation for the mass?to?charge ratios to be within the working range of the mass spectrometer. Analysis

  8. Isolation and Puification of Uranium Isotopes for Measurement by Mass-Spectrometry (233, 234, 235, 236, 238U) and Alpha Spectrometry (232U)

    SciTech Connect (OSTI)

    Marinelli, R; Hamilton, T; Brown, T; Marchetti, A; Williams, R; Tumey, S

    2006-05-30

    This report describes a standardized methodology used by researchers from the Center for Accelerator Mass Spectrometry (CAMS) (Energy and Environment Directorate) and the Environmental Radiochemistry Group (Chemistry and Materials Science Directorate) at the Lawrence Livermore National Laboratory (LLNL) for the full isotopic analysis of uranium from solution. The methodology has largely been developed for use in characterizing the uranium composition of selected nuclear materials but may also be applicable to environmental studies and assessments of public, military or occupational exposures to uranium using in-vitro bioassay monitoring techniques. Uranium isotope concentrations and isotopic ratios are measured using a combination of Multi Collector Inductively Coupled Plasma Mass Spectrometry (MC ICP-MS), Accelerator Mass Spectrometry (AMS) and Alpha Spectrometry.

  9. Analysis of perchlorate in groundwater by electrospray ionization mass spectrometry/mass spectrometry

    SciTech Connect (OSTI)

    Koester, C.J.; Beller, H.R.; Halden, R.U.

    2000-05-01

    An electrospray ionization mass spectrometry/mass spectrometry (ESI/MS/MS) method was developed to measure part-per-billion ({micro}g/L) concentrations of perchlorate in groundwater. Selective and sensitive perchlorate detection was achieved by operating the mass spectrometer in the negative ionization mode and by using MS/MS to monitor the CIO{sub 4}{sup {minus}} to ClO{sub 3}{sup {minus}} transition. The method of standard additions was used to address the considerable signal suppression caused by anions that are typically present in groundwater, such as bicarbonate and sulfate. ESI-MS/MS analysis was rapid, accurate, reproducible, and provided a detection limit of 0.5 {micro}g/L perchlorate in groundwater. Accuracy and precision of the ESI/MS/MS method were assessed by analyzing performance evaluation samples in a groundwater matrix and by comparing ion chromatography (IC) and ESI/MS/MS results for local groundwater samples. Results for the performance evaluation samples differed from the certified values by 4--13%, and precision ranged from 3 to 10% (relative standard deviation). The IC and ESI/MS/MS results were statistically indistinguishable for perchlorate concentrations above the detection limits of both methods.

  10. SAMDI Mass Spectrometry for High Throughput Discovery of Enzyme...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SAMDI Mass Spectrometry for High Throughput Discovery of Enzyme Function January 15, 2016 11:00AM to 12:00PM Presenter Milan Mrksich, Northwestern University Location Building 446,...

  11. Subcellular analysis by laser ablation electrospray ionization mass spectrometry

    DOE Patents [OSTI]

    Vertes, Akos; Stolee, Jessica A; Shrestha, Bindesh

    2014-12-02

    In various embodiments, a method of laser ablation electrospray ionization mass spectrometry (LAESI-MS) may generally comprise micro-dissecting a cell comprising at least one of a cell wall and a cell membrane to expose at least one subcellular component therein, ablating the at least one subcellular component by an infrared laser pulse to form an ablation plume, intercepting the ablation plume by an electrospray plume to form ions, and detecting the ions by mass spectrometry.

  12. Direct analysis of samples by mass spectrometry: From elements to bio-molecules using laser ablation inductively couple plasma mass spectrometry and laser desorption/ionization mass spectrometry

    SciTech Connect (OSTI)

    Perdian, David C.

    2009-08-19

    Mass spectrometric methods that are able to analyze solid samples or biological materials with little or no sample preparation are invaluable to science as well as society. Fundamental research that has discovered experimental and instrumental parameters that inhibit fractionation effects that occur during the quantification of elemental species in solid samples by laser ablation inductively coupled plasma mass spectrometry is described. Research that determines the effectiveness of novel laser desorption/ionization mass spectrometric methods for the molecular analysis of biological tissues at atmospheric pressure and at high spatial resolution is also described. A spatial resolution is achieved that is able to analyze samples at the single cell level.

  13. Aerosol mass spectrometry systems and methods

    DOE Patents [OSTI]

    Fergenson, David P.; Gard, Eric E.

    2013-08-20

    A system according to one embodiment includes a particle accelerator that directs a succession of polydisperse aerosol particles along a predetermined particle path; multiple tracking lasers for generating beams of light across the particle path; an optical detector positioned adjacent the particle path for detecting impingement of the beams of light on individual particles; a desorption laser for generating a beam of desorbing light across the particle path about coaxial with a beam of light produced by one of the tracking lasers; and a controller, responsive to detection of a signal produced by the optical detector, that controls the desorption laser to generate the beam of desorbing light. Additional systems and methods are also disclosed.

  14. Laser Mass Spectrometry in Planetary Science

    SciTech Connect (OSTI)

    Wurz, P.; Whitby, J. A.; Managadze, G. G.

    2009-06-16

    Knowing the chemical, elemental, and isotopic composition of planetary objects allows the study of their origin and evolution within the context of our solar system. Exploration plans in planetary research of several space agencies consider landing spacecraft for future missions. Although there have been successful landers in the past, more landers are foreseen for Mars and its moons, Venus, the jovian moons, and asteroids. Furthermore, a mass spectrometer on a landed spacecraft can assist in the sample selection in a sample-return mission and provide mineralogical context, or identify possible toxic soils on Mars for manned Mars exploration. Given the resources available on landed spacecraft mass spectrometers, as well as any other instrument, have to be highly miniaturised.

  15. Coming to a hospital near you: mass spectrometry imaging

    ScienceCinema (OSTI)

    Bowen, Ben

    2014-06-24

    Berkeley Lab's Ben Bowen discusses "Coming to a hospital near you: mass spectrometry imaging" in this Oct. 28, 2013 talk, which is part of a Science at the Theater event entitled Eight Big Ideas. Go here to watch the entire event with all 8 speakers.

  16. Charge Prediction of Lipid Fragments in Mass Spectrometry

    SciTech Connect (OSTI)

    Schrom, Brian T.; Kangas, Lars J.; Ginovska, Bojana; Metz, Thomas O.; Miller, John H.

    2011-12-18

    An artificial neural network is developed for predicting which fragment is charged and which fragment is neutral for lipid fragment pairs produced from a liquid chromatography tandem mass spectrometry simulation process. This charge predictor is integrated into software developed at PNNL for in silico spectra generation and identification of metabolites known as Met ISIS. To test the effect of including charge prediction in Met ISIS, 46 lipids are used which show a reduction in false positive identifications when the charge predictor is utilized.

  17. Sheathless interface for coupling capillary electrophoresis with mass spectrometry

    SciTech Connect (OSTI)

    Wang, Chenchen; Tang, Keqi; Smith, Richard D.

    2014-06-17

    A sheathless interface for coupling capillary electrophoresis (CE) with mass spectrometry is disclosed. The sheathless interface includes a separation capillary for performing CE separation and an emitter capillary for electrospray ionization. A portion of the emitter capillary is porous or, alternatively, is coated to form an electrically conductive surface. A section of the emitter capillary is disposed within the separation capillary, forming a joint. A metal tube, containing a conductive liquid, encloses the joint.

  18. Monitoring Trace Radionuclides by ICP Mass Spectrometry with Femtosecond

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Laser Ablation | The Ames Laboratory Monitoring Trace Radionuclides by ICP Mass Spectrometry with Femtosecond Laser Ablation FWP/Project Description: This project will develop analytical methodology for the use of femtosecond laser ablation sampling and analysis techniques for the rapid screening of samples derived from detection of clandestine nuclear operations, and nuclear non-proliferation and safeguards activities. A state-of-the-art femtosecond laser ablation system in conjunction with

  19. Future Directions of Structural Mass Spectrometry using Hydroxyl Radical Footprinting

    SciTech Connect (OSTI)

    J Kiselar; M Chance

    2011-12-31

    Hydroxyl radical protein footprinting coupled to mass spectrometry has been developed over the last decade and has matured to a powerful method for analyzing protein structure and dynamics. It has been successfully applied in the analysis of protein structure, protein folding, protein dynamics, and protein-protein and protein-DNA interactions. Using synchrotron radiolysis, exposure of proteins to a 'white' X-ray beam for milliseconds provides sufficient oxidative modification to surface amino acid side chains, which can be easily detected and quantified by mass spectrometry. Thus, conformational changes in proteins or protein complexes can be examined using a time-resolved approach, which would be a valuable method for the study of macromolecular dynamics. In this review, we describe a new application of hydroxyl radical protein footprinting to probe the time evolution of the calcium-dependent conformational changes of gelsolin on the millisecond timescale. The data suggest a cooperative transition as multiple sites in different molecular subdomains have similar rates of conformational change. These findings demonstrate that time-resolved protein footprinting is suitable for studies of protein dynamics that occur over periods ranging from milliseconds to seconds. In this review, we also show how the structural resolution and sensitivity of the technology can be improved as well. The hydroxyl radical varies in its reactivity to different side chains by over two orders of magnitude, thus oxidation of amino acid side chains of lower reactivity are more rarely observed in such experiments. Here we demonstrate that the selected reaction monitoring (SRM)-based method can be utilized for quantification of oxidized species, improving the signal-to-noise ratio. This expansion of the set of oxidized residues of lower reactivity will improve the overall structural resolution of the technique. This approach is also suggested as a basis for developing hypothesis-driven structural mass spectrometry experiments.

  20. Method for predicting peptide detection in mass spectrometry

    DOE Patents [OSTI]

    Kangas, Lars [West Richland, WA; Smith, Richard D [Richland, WA; Petritis, Konstantinos [Richland, WA

    2010-07-13

    A method of predicting whether a peptide present in a biological sample will be detected by analysis with a mass spectrometer. The method uses at least one mass spectrometer to perform repeated analysis of a sample containing peptides from proteins with known amino acids. The method then generates a data set of peptides identified as contained within the sample by the repeated analysis. The method then calculates the probability that a specific peptide in the data set was detected in the repeated analysis. The method then creates a plurality of vectors, where each vector has a plurality of dimensions, and each dimension represents a property of one or more of the amino acids present in each peptide and adjacent peptides in the data set. Using these vectors, the method then generates an algorithm from the plurality of vectors and the calculated probabilities that specific peptides in the data set were detected in the repeated analysis. The algorithm is thus capable of calculating the probability that a hypothetical peptide represented as a vector will be detected by a mass spectrometry based proteomic platform, given that the peptide is present in a sample introduced into a mass spectrometer.

  1. Laser ablation electrospray ionization (LAESI) for atmospheric pressure, in vivo, and imaging mass spectrometry

    DOE Patents [OSTI]

    Vertes, Akos; Nemes, Peter

    2014-08-19

    The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI).

  2. Laser ablation electrospray ionization (LAESI) for atmospheric pressure, In vivo, and imaging mass spectrometry

    DOE Patents [OSTI]

    Vertes, Akos (Reston, VA); Nemes, Peter (Silver Spring, MD)

    2011-11-29

    The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation (LA) with electrospray ionization (ESI).

  3. Laser ablation electrospray ionization (LAESI) for atmospheric pressure, in vivo, and imaging mass spectrometry

    DOE Patents [OSTI]

    Vertes, Akos; Nemes, Peter

    2013-07-16

    The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI).

  4. Three-dimensional molecular imaging by infrared laser ablation electrospray ionization mass spectrometry

    DOE Patents [OSTI]

    Vertes, Akos (Reston, VA); Nemes, Peter (Silver Spring, MD)

    2011-06-21

    The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI).

  5. Three-dimensional molecular imaging by infrared laser ablation electrospray ionization mass spectrometry

    DOE Patents [OSTI]

    Vertes, Akos; Nemes, Peter

    2013-07-16

    The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI).

  6. Three-dimensional molecular imaging by infrared laser ablation electrospray ionization mass spectrometry

    DOE Patents [OSTI]

    Vertes, Akos; Nemes, Peter

    2012-10-30

    The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI).

  7. IMPULSIVE ACCELERATION OF CORONAL MASS EJECTIONS. I. STATISTICS AND CORONAL MASS EJECTION SOURCE REGION CHARACTERISTICS

    SciTech Connect (OSTI)

    Bein, B. M.; Berkebile-Stoiser, S.; Veronig, A. M.; Temmer, M.; Muhr, N.; Kienreich, I.; Utz, D.

    2011-09-10

    We use high time cadence images acquired by the STEREO EUVI and COR instruments to study the evolution of coronal mass ejections (CMEs) from their initiation through impulsive acceleration to the propagation phase. For a set of 95 CMEs we derived detailed height, velocity, and acceleration profiles and statistically analyzed characteristic CME parameters: peak acceleration, peak velocity, acceleration duration, initiation height, height at peak velocity, height at peak acceleration, and size of the CME source region. The CME peak accelerations we derived range from 20 to 6800 m s{sup -2} and are inversely correlated with the acceleration duration and the height at peak acceleration. Seventy-four percent of the events reach their peak acceleration at heights below 0.5 R{sub sun}. CMEs that originate from compact sources low in the corona are more impulsive and reach higher peak accelerations at smaller heights. These findings can be explained by the Lorentz force, which drives the CME accelerations and decreases with height and CME size.

  8. Focus on Advancing High Performance Mass Spectrometry, Honoring Dr. Richard D. Smith, Recipient of the 2013 Award for a Distinguished Contribution in Mass Spectrometry

    SciTech Connect (OSTI)

    Baker, Erin Shammel; Muddiman, David C.; Loo, Joseph

    2014-12-01

    This special focus issue of the Journal of the American Society for Mass Spectrometry celebrates the accomplishments of Dr. Richard D. Smith, the recipient of the 2013ASMS Award for a Distinguished Contribution in Mass Spectrometry, and who serves as a Battelle Fellow, Chief Scientist in the Biological Sciences Division, and Director of Proteomics Research at Pacific Northwest National Laboratory (PNNL) in Richland, WA. The award is for his development of the electrodynamic ion funnel.

  9. Matrix Effects in Biological Mass Spectrometry Imaging: Identification and Compensation

    SciTech Connect (OSTI)

    Lanekoff, Ingela T.; Stevens, Susan; Stenzel-Poore, Mary; Laskin, Julia

    2014-07-21

    Matrix effects in mass spectrometry imaging (MSI) may affect the observed molecular distribution in chemical and biological systems. In this study, we introduce an experimental approach that efficiently compensates for matrix effects in nanospray desorption electrospray ionization (nano-DESI) MSI without introducing any complexity into the experimental protocol. We demonstrate compensation for matrix effects in nano-DESI MSI of phosphatidylcholine (PC) in normal and ischemic mouse brain tissue by doping the nano-DESI solvent with PC standards. Specifically, we use mouse brain tissue of a middle cerebral artery occlusion (MCAO) stroke model with an ischemic region localized to one hemisphere of the brain. Due to similar suppression in ionization of endogenous PC molecules extracted from the tissue and PC standards added to the solvent, matrix effects are eliminated by normalizing the intensity of the sodium and potassium adducts of endogenous PC to the intensity of the corresponding adduct of the PC standard. This approach efficiently compensates for signal variations resulting from differences in the local concentrations of sodium and potassium in tissue sections and from the complexity of the extracted analyte mixture derived from local variations in molecular composition.

  10. Trace elements in coal by glow discharge mass spectrometry

    SciTech Connect (OSTI)

    Jacobs, M.L.; Wilson, C.R.; Pestovich, J. Jr.

    1995-08-01

    A need and a demand exist for determining trace elements in coal and coal related by-products, especially those elements which may potentially be a health hazard. The provisions of the 1990 clean air act require that the EPA evaluate the emissions of electric utilities for trace elements and other potentially hazardous organic compounds. The coal fired electric utility industry supplies roughly 60% of the total generating capacity of 2,882,525 million kilowatt hours (nearly 3 trillion kilowatt hours) generated in the U.S. This is accomplished by 414 power plants scattered across the country that burned 813,508,000 short tons of coal in 1993. The relative volatility of some inorganic constituents in coal makes them more prone to be emitted to the atmosphere following combustion. The production of analytical data for trace elements is known to be a difficult task in coal and by-products of coal combustion (fly ash, bottom ash, gas streams, etc.), in terms of both sample collection and analytical determinations. There are several common analytical methods available to the analyst to determine trace elements in coal and coal by-products. In general analytical germs, the material to be analyzed can be totally solubilized (or extracted), or the elements analytes can be determined in the material as a solid. A relatively new elemental technique, Glow Discharge Mass Spectrometry (GDMS) can be used with solids as well. This new analytical technique had never before been applied directly to coal. The radio frequency-glow discharge quadropole mass spectrometer was used to analyze coal directly for the first time ever by rf-GDMS. The rf-GDMS technique is described.

  11. IDENTIFICATION OF STAPHYLOCOCCAL SPECIES BASED ON VARIATIONS IN PROTEIN SEQUENCES (MASS SPECTROMETRY) AND DNA SEQUENCE (sodA MICROARRAY)

    SciTech Connect (OSTI)

    Kooken, Jennifer M.; Fox, Karen F.; Fox, Alvin; Altomare, Diego; Creek, Kim E.; Wunschel, David S.; Pajares-Merino, Sara; Martinez-Ballesteros, Ilargi; Garaizar, Javier; Oyarzabal, Omar A.; Samadpour, Mansour

    2014-02-03

    IDENTIFICATION OF STAPHYLOCOCCAL SPECIES BASED ON VARIATIONS IN PROTEIN SEQUENCES (MASS SPECTROMETRY) AND DNA SEQUENCE (sodA MICROARRAY)

  12. ASSESSMENT OF MARKER PROTEINS IDENTIFIED IN WHOLE CELL EXTRACTS FOR BACTERIAL SPECIATION USING LIQUID CHROMATOGRAPHY ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY

    SciTech Connect (OSTI)

    Kooken, Jennifer M.; Fox, Karen F.; Fox, Alvin; Wunschel, David S.

    2014-02-02

    ASSESSMENT OF MARKER PROTEINS IDENTIFIED IN WHOLE CELL EXTRACTS FOR BACTERIAL SPECIATION USING LIQUID CHROMATOGRAPHY ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY

  13. A new detector for mass spectrometry: Direct detection of low energy ions

    Office of Scientific and Technical Information (OSTI)

    using a multi-pixel photon counter (Journal Article) | SciTech Connect A new detector for mass spectrometry: Direct detection of low energy ions using a multi-pixel photon counter Citation Details In-Document Search Title: A new detector for mass spectrometry: Direct detection of low energy ions using a multi-pixel photon counter A new type of ion detector for mass spectrometry and general detection of low energy ions is presented. The detector consists of a scintillator optically coupled to

  14. Fractal morphology, imaging and mass spectrometry of single aerosol particles in flight (CXIDB ID 16)

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Loh, N. Duane

    2012-06-20

    This deposition includes the aerosol diffraction images used for phasing, fractal morphology, and time-of-flight mass spectrometry. Files in this deposition are ordered in subdirectories that reflect the specifics.

  15. Improvements to Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    for Quantitative Analysis using Short Pulse UV Laser | The Ames Laboratory Improvements to Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry for Quantitative Analysis using Short Pulse UV Laser FWP/Project Description: Laser ablation inductively coupled plasma-mass spectrometry (LA-ICP-MS) is a non-destructive method for trace elemental analysis of solids. Trace element composition can be useful in forensic applications for matching or attribution studies, in which a material

  16. RAPID DETERMINATION OF 237 NP AND PU ISOTOPES IN WATER BY INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY AND ALPHA SPECTROMETRY

    SciTech Connect (OSTI)

    Maxwell, S.; Jones, V.; Culligan, B.; Nichols, S.; Noyes, G.

    2010-06-23

    A new method that allows rapid preconcentration and separation of plutonium and neptunium in water samples was developed for the measurement of {sup 237}Np and Pu isotopes by inductively-coupled plasma mass spectrometry (ICP-MS) and alpha spectrometry; a hybrid approach. {sup 238}U can interfere with {sup 239}Pu measurement by ICP-MS as {sup 238}UH{sup +} mass overlap and {sup 237}Np via peak tailing. The method provide enhanced removal of uranium by separating Pu and Np initially on TEVA Resin, then moving Pu to DGA resin for additional removal of uranium. The decontamination factor for uranium from Pu is almost 100,000 and the decontamination factor for U from Np is greater than 10,000. This method uses stacked extraction chromatography cartridges and vacuum box technology to facilitate rapid separations. Preconcentration is performed using a streamlined calcium phosphate precipitation method. Purified solutions are split between ICP-MS and alpha spectrometry so that long and short-lived Pu isotopes can be measured successfully. The method allows for simultaneous extraction of 20 samples (including QC samples) in 4 to 6 hours, and can also be used for emergency response. {sup 239}Pu, {sup 242}Pu and {sup 237}Np were measured by ICP-MS, while {sup 236}Pu, {sup 238}Pu, and {sup 239}Pu were measured by alpha spectrometry.

  17. Apparatus and methods for continuous beam fourier transform mass spectrometry

    DOE Patents [OSTI]

    McLuckey, Scott A.; Goeringer, Douglas E.

    2002-01-01

    A continuous beam Fourier transform mass spectrometer in which a sample of ions to be analyzed is trapped in a trapping field, and the ions in the range of the mass-to-charge ratios to be analyzed are excited at their characteristic frequencies of motion by a continuous excitation signal. The excited ions in resonant motions generate real or image currents continuously which can be detected and processed to provide a mass spectrum.

  18. Method and apparatus for multispray emitter for mass spectrometry

    DOE Patents [OSTI]

    Smith, Richard D.; Tang, Keqi; Lin, Yuehe

    2004-12-14

    A method and apparatus that utilizes two or more emitters simultaneously to form an electrospray of a sample that is then directed into a mass spectrometer, thereby increasing the total ion current introduced into an electrospray ionization mass spectrometer, given a liquid flow rate of a sample. The method and apparatus are most conveniently constructed as an array of spray emitters fabricated on a single chip, however, the present invention encompasses any apparatus wherein two or more emitters are simultaneously utilized to form an electrospray of a sample that is then directed into a mass spectrometer.

  19. Noise reduction in negative-ion quadrupole mass spectrometry

    DOE Patents [OSTI]

    Chastagner, P.

    1993-04-20

    A quadrupole mass spectrometer (QMS) system is described having an ion source, quadrupole mass filter, and ion collector/recorder system. A weak, transverse magnetic field and an electron collector are disposed between the quadrupole and ion collector. When operated in negative ion mode, the ion source produces a beam of primarily negatively-charged particles from a sample, including electrons as well as ions. The beam passes through the quadrupole and enters the magnetic field, where the electrons are deflected away from the beam path to the electron collector. The negative ions pass undeflected to the ion collector where they are detected and recorded as a mass spectrum.

  20. Structural determination of intact proteins using mass spectrometry

    DOE Patents [OSTI]

    Kruppa, Gary; Schoeniger, Joseph S.; Young, Malin M.

    2008-05-06

    The present invention relates to novel methods of determining the sequence and structure of proteins. Specifically, the present invention allows for the analysis of intact proteins within a mass spectrometer. Therefore, preparatory separations need not be performed prior to introducing a protein sample into the mass spectrometer. Also disclosed herein are new instrumental developments for enhancing the signal from the desired modified proteins, methods for producing controlled protein fragments in the mass spectrometer, eliminating complex microseparations, and protein preparatory chemical steps necessary for cross-linking based protein structure determination.Additionally, the preferred method of the present invention involves the determination of protein structures utilizing a top-down analysis of protein structures to search for covalent modifications. In the preferred method, intact proteins are ionized and fragmented within the mass spectrometer.

  1. Reflection mass spectrometry technique for monitoring and controlling composition during molecular beam epitaxy

    DOE Patents [OSTI]

    Brennan, T.M.; Hammons, B.E.; Tsao, J.Y.

    1992-12-15

    A method for on-line accurate monitoring and precise control of molecular beam epitaxial growth of Groups III-III-V or Groups III-V-V layers in an advanced semiconductor device incorporates reflection mass spectrometry. The reflection mass spectrometry is responsive to intentional perturbations in molecular fluxes incident on a substrate by accurately measuring the molecular fluxes reflected from the substrate. The reflected flux is extremely sensitive to the state of the growing surface and the measurements obtained enable control of newly forming surfaces that are dynamically changing as a result of growth. 3 figs.

  2. Reflection mass spectrometry technique for monitoring and controlling composition during molecular beam epitaxy

    DOE Patents [OSTI]

    Brennan, Thomas M.; Hammons, B. Eugene; Tsao, Jeffrey Y.

    1992-01-01

    A method for on-line accurate monitoring and precise control of molecular beam epitaxial growth of Groups III-III-V or Groups III-V-V layers in an advanced semiconductor device incorporates reflection mass spectrometry. The reflection mass spectrometry is responsive to intentional perturbations in molecular fluxes incident on a substrate by accurately measuring the molecular fluxes reflected from the substrate. The reflected flux is extremely sensitive to the state of the growing surface and the measurements obtained enable control of newly forming surfaces that are dynamically changing as a result of growth.

  3. Apparatus for preparing a sample for mass spectrometry

    DOE Patents [OSTI]

    Villa-Aleman, Eliel (Aiken, SC)

    1994-01-01

    An apparatus for preparing a sample for analysis by a mass spectrometer system. The apparatus has an entry chamber and an ionization chamber separated by a skimmer. A capacitor having two space-apart electrodes followed by one or more ion-imaging lenses is disposed in the ionization chamber. The chamber is evacuated and the capacitor is charged. A valve injects a sample gas in the form of sample pulses into the entry chamber. The pulse is collimated by the skimmer and enters the ionization chamber. When the sample pulse passes through the gap between the electrodes, it discharges the capacitor and is thereby ionized. The ions are focused by the imaging lenses and enter the mass analyzer, where their mass and charge are analyzed.

  4. Apparatus for preparing a sample for mass spectrometry

    DOE Patents [OSTI]

    Villa-Aleman, E.

    1994-05-10

    An apparatus is described for preparing a sample for analysis by a mass spectrometer system. The apparatus has an entry chamber and an ionization chamber separated by a skimmer. A capacitor having two space-apart electrodes followed by one or more ion-imaging lenses is disposed in the ionization chamber. The chamber is evacuated and the capacitor is charged. A valve injects a sample gas in the form of sample pulses into the entry chamber. The pulse is collimated by the skimmer and enters the ionization chamber. When the sample pulse passes through the gap between the electrodes, it discharges the capacitor and is thereby ionized. The ions are focused by the imaging lenses and enter the mass analyzer, where their mass and charge are analyzed. 1 figures.

  5. Atmospheric pressure plasma analysis by modulated molecular beam mass spectrometry

    SciTech Connect (OSTI)

    Aranda Gonzalvo, Y.; Whitmore, T.D.; Rees, J.A.; Seymour, D.L.; Stoffels, E.

    2006-05-15

    Fractional number density measurements for a rf plasma 'needle' operating at atmospheric pressure have been obtained using a molecular beam mass spectrometer (MBMS) system designed for diagnostics of atmospheric plasmas. The MBMS system comprises three differentially pumped stages and a mass/energy analyzer and includes an automated beam-to-background measurement facility in the form of a software-controlled chopper mechanism. The automation of the beam modulation allows the neutral components in the plasma to be rapidly and accurately measured using the mass spectrometer by threshold ionization techniques. Data are reported for plasma generated by a needle plasma source operated using a helium/air mixture. In particular, data for the conversion of atmospheric oxygen and nitrogen into nitric oxide are discussed with reference to its significance for medical applications such as disinfecting wounds and dental cavities and for microsurgery.

  6. RAPID DETERMINATION OF ACTINIDES IN URINE BY INDUCTIVELY-COUPLED PLASMA MASS SPECTROMETRY AND ALPHA SPECTROMETRY: A HYBRID APPROACH

    SciTech Connect (OSTI)

    Maxwell, S.; Jones, V.

    2009-05-27

    A new rapid separation method that allows separation and preconcentration of actinides in urine samples was developed for the measurement of longer lived actinides by inductively coupled plasma mass spectrometry (ICP-MS) and short-lived actinides by alpha spectrometry; a hybrid approach. This method uses stacked extraction chromatography cartridges and vacuum box technology to facilitate rapid separations. Preconcentration, if required, is performed using a streamlined calcium phosphate precipitation. Similar technology has been applied to separate actinides prior to measurement by alpha spectrometry, but this new method has been developed with elution reagents now compatible with ICP-MS as well. Purified solutions are split between ICP-MS and alpha spectrometry so that long- and short-lived actinide isotopes can be measured successfully. The method allows for simultaneous extraction of 24 samples (including QC samples) in less than 3 h. Simultaneous sample preparation can offer significant time savings over sequential sample preparation. For example, sequential sample preparation of 24 samples taking just 15 min each requires 6 h to complete. The simplicity and speed of this new method makes it attractive for radiological emergency response. If preconcentration is applied, the method is applicable to larger sample aliquots for occupational exposures as well. The chemical recoveries are typically greater than 90%, in contrast to other reported methods using flow injection separation techniques for urine samples where plutonium yields were 70-80%. This method allows measurement of both long-lived and short-lived actinide isotopes. 239Pu, 242Pu, 237Np, 243Am, 234U, 235U and 238U were measured by ICP-MS, while 236Pu, 238Pu, 239Pu, 241Am, 243Am and 244Cm were measured by alpha spectrometry. The method can also be adapted so that the separation of uranium isotopes for assay is not required, if uranium assay by direct dilution of the urine sample is preferred instead. Multiple vacuum box locations may be set-up to supply several ICP-MS units with purified sample fractions such that a high sample throughput may be achieved, while still allowing for rapid measurement of short-lived actinides by alpha spectrometry.

  7. Ion source for high-precision mass spectrometry

    DOE Patents [OSTI]

    Todd, P.J.; McKown, H.S.; Smith, D.H.

    1982-04-26

    The invention is directed to a method for increasing the precision of positive-ion relative abundance measurements conducted in a sector mass spectrometer having an ion source for directing a beam of positive ions onto a collimating slit. The method comprises incorporating in the source an electrostatic lens assembly for providing a positive-ion beam of circular cross section for collimation by the slit. 2 figures, 3 tables.

  8. Apparatus and method for hydrogen and oxygen mass spectrometry of the terrestrial magnetosphere

    DOE Patents [OSTI]

    Funsten, Herbert O. (Los Alamos, NM); Dors, Eric E. (Los Alamos, NM); Harper, Ronnie W. (Los Alamos, NM); Reisenfeld, Daniel B. (Stevensville, MT)

    2007-05-15

    A detector element for mass spectrometry of a flux of heavy and light ions, that includes: a first detector to detect light ions that transit through a foil operatively placed in front of the first detector, and a second detector that detects the flux of heavy and light ions.

  9. OpenMSI: A High-Performance Web-Based Platform for Mass Spectrometry Imaging

    SciTech Connect (OSTI)

    Rubel, Oliver; Greiner, Annette; Cholia, Shreyas; Louie, Katherine; Bethel, E. Wes; Northen, Trent R.; Bowen, Benjamin P.

    2013-10-02

    Mass spectrometry imaging (MSI) enables researchers to directly probe endogenous molecules directly within the architecture of the biological matrix. Unfortunately, efficient access, management, and analysis of the data generated by MSI approaches remain major challenges to this rapidly developing field. Despite the availability of numerous dedicated file formats and software packages, it is a widely held viewpoint that the biggest challenge is simply opening, sharing, and analyzing a file without loss of information. Here we present OpenMSI, a software framework and platform that addresses these challenges via an advanced, high-performance, extensible file format and Web API for remote data access (http://openmsi.nersc.gov). The OpenMSI file format supports storage of raw MSI data, metadata, and derived analyses in a single, self-describing format based on HDF5 and is supported by a large range of analysis software (e.g., Matlab and R) and programming languages (e.g., C++, Fortran, and Python). Careful optimization of the storage layout of MSI data sets using chunking, compression, and data replication accelerates common, selective data access operations while minimizing data storage requirements and are critical enablers of rapid data I/O. The OpenMSI file format has shown to provide >2000-fold improvement for image access operations, enabling spectrum and image retrieval in less than 0.3 s across the Internet even for 50 GB MSI data sets. To make remote high-performance compute resources accessible for analysis and to facilitate data sharing and collaboration, we describe an easy-to-use yet powerful Web API, enabling fast and convenient access to MSI data, metadata, and derived analysis results stored remotely to facilitate high-performance data analysis and enable implementation of Web based data sharing, visualization, and analysis.

  10. Laser photoionization time-of-flight mass spectrometry of nitrated polycyclic aromatic hydrocarbons and nitrated heterocyclic compounds. Master's thesis

    SciTech Connect (OSTI)

    Noyes, R.A.

    1993-01-01

    Partial Contents: Laser Desorption-Laser Photoionization Time-of-Flight Mass Spectrometry; Basic Principles of TOFMS; Factors Affecting Flight Time; Source of Broadening; Laser Desorption; Theory of Multiphoton Ionization: Application to Mass Spectrometry; Quantum Theory of MPI; Time-Dependent Perturbation Theory; Time-Dependent Coefficients; Probability of a Two-Photon Process; and Attributes of R2PI.

  11. High explosives vapor detection by atmospheric sampling glow discharge ionization/tandem mass spectrometry

    SciTech Connect (OSTI)

    McLuckey, S.A.; Goeringer, D.E.; Asano, K.G.

    1996-02-01

    The combination of atmospheric sampling glow discharge ionization with tandem mass spectrometry for the detection of traces of high explosives is described. Particular emphasis is placed on use of the quadrupole ion trap as the type of tandem mass spectrometer. Atmospheric sampling glow discharge provides a simple, rugged, and efficient means for anion formation while the quadrupole ion trap provides for efficient tandem mass spectrometry. Mass selective ion accumulation and non-specific ion activation methods can be used to overcome deleterious effects arising from ion/ion interactions. Such interactions constitute the major potential technical barrier to the use of the ion trap for real-time monitoring of targeted compounds in uncontrolled and highly variable matrices. Tailored waveforms can be used to effect both mass selective ion accumulation and ion activation. Concatenated tailored waveforms allow for both functions in a single experiment thereby providing the capability for monitoring several targeted species simultaneously. The combination of atmospheric sampling glow discharge ionization with a state-of-the-art analytical quadrupole ion trap is a highly sensitive and specific detector for traces of high explosives. The combination is also small and inexpensive relative to virtually any other form of tandem mass spectrometry. The science and technology underlying the glow discharge/ion trap combination is sufficiently mature to form the basis for an engineering effort to make the detector portable. 85 refs.

  12. Plume collimation for laser ablation electrospray ionization mass spectrometry

    DOE Patents [OSTI]

    Vertes, Akos; Stolee, Jessica A.

    2014-09-09

    In various embodiments, a device may generally comprise a capillary having a first end and a second end; a laser to emit energy at a sample in the capillary to ablate the sample and generate an ablation plume in the capillary; an electrospray apparatus to generate an electrospray plume to intercept the ablation plume to produce ions; and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation plume may comprise a collimated ablation plume. The device may comprise a flow cytometer. Methods of making and using the same are also described.

  13. Sampling probe for microarray read out using electrospray mass spectrometry

    DOE Patents [OSTI]

    Van Berkel, Gary J.

    2004-10-12

    An automated electrospray based sampling system and method for analysis obtains samples from surface array spots having analytes. The system includes at least one probe, the probe including an inlet for flowing at least one eluting solvent to respective ones of a plurality of spots and an outlet for directing the analyte away from the spots. An automatic positioning system is provided for translating the probe relative to the spots to permit sampling of any spot. An electrospray ion source having an input fluidicly connected to the probe receives the analyte and generates ions from the analyte. The ion source provides the generated ions to a structure for analysis to identify the analyte, preferably being a mass spectrometer. The probe can be a surface contact probe, where the probe forms an enclosing seal along the periphery of the array spot surface.

  14. Mass Spectrometry Imaging of Biological Tissue: An Approach for Multicenter Studies

    SciTech Connect (OSTI)

    Rompp, Andreas; Both, Jean-Pierre; Brunelle, Alain; Heeren, Ronald M.; Laprevote, Olivier; Prideaux, Brendan; Seyer, Alexandre; Spengler, Bernhard; Stoeckli, Markus; Smith, Donald F.

    2015-03-01

    Mass spectrometry imaging has become a popular tool for probing the chemical complexity of biological surfaces. This led to the development of a wide range of instrumentation and preparation protocols. It is thus desirable to evaluate and compare the data output from different methodologies and mass spectrometers. Here, we present an approach for the comparison of mass spectrometry imaging data from different laboratories (often referred to as multicenter studies). This is exemplified by the analysis of mouse brain sections in five laboratories in Europe and the USA. The instrumentation includes matrix-assisted laser desorption/ionization (MALDI)-time-of-flight (TOF), MALDI-QTOF, MALDIFourier transform ion cyclotron resonance (FTICR), atmospheric-pressure (AP)-MALDI-Orbitrap, and cluster TOF-secondary ion mass spectrometry (SIMS). Experimental parameters such as measurement speed, imaging bin width, and mass spectrometric parameters are discussed. All datasets were converted to the standard data format imzML and displayed in a common open-source software with identical parameters for visualization, which facilitates direct comparison of MS images. The imzML conversion also allowed exchange of fully functional MS imaging datasets between the different laboratories. The experiments ranged from overview measurements of the full mouse brain to detailed analysis of smaller features (depending on spatial resolution settings), but common histological features such as the corpus callosum were visible in all measurements. High spatial resolution measurements of AP-MALDI-Orbitrap and TOF-SIMS showed comparable structures in the low-micrometer range. We discuss general considerations for planning and performing multicenter studies in mass spectrometry imaging. This includes details on the selection, distribution, and preparation of tissue samples as well as on data handling. Such multicenter studies in combination with ongoing activities for reporting guidelines, a common data format (imzML) and a public data repository can contribute to more reliability and transparency of MS imaging studies.

  15. Mass Spectrometry Data from the Biological MS Data and Software Distribution Center

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Anderson, Gordon

    The mass spectrometry capabilities at Pacific Northwest National Laboratory (PNNL) are primarily applied to biological research, with an emphasis on proteomics and metabolomics. Many of these cutting-edge mass spectrometry capabilities and bioinformatics methods are housed in the Department of Energy's Environmental Molecular Sciences Laboratory (EMSL), a national scientific user facility operated by PNNL. These capabilities have been developed and acquired through cooperation between the EMSL national scientific user program and PNNL programmatic research. At the website of the Biological MS Data and Software Distribution Center, the following resources are made available: PNNL-developed software tools and source code, PNNL-generated raw data and processed results, links to publications that used the data and results available on this site, and tutorials and user manuals. [taken from http://omics.pnl.gov/

  16. Determination of atmospheric carbonyl sulfide by isotope dilution gas chromatography/mass spectrometry

    SciTech Connect (OSTI)

    Lewin, E.E.; Taggart, R.L.; Lalevic, M.; Bandy, A.R.

    1987-05-01

    A gas chromatography/mass spectrometry (GB/MS) method for determining atmospheric carbonyl sulfide (OCS) with a precision better than 2% is reported. High precision and insensitivity to sample loss and changes in detector response were achieved by using isotopically labeled OCS as an internal standard. Tenax, Molecular Sieve 5A, Carbosieve B, and Carbosieve S were evaluated for collecting atmospheric OCS. Molecular Sieve 5A provided the best trapping and recovery efficiencies.

  17. Ultra-high-mass mass spectrometry with charge discrimination using cryogenic detectors

    DOE Patents [OSTI]

    Frank, Matthias (Berkeley, CA); Mears, Carl A. (Oakland, CA); Labov, Simon E. (Berkeley, CA); Benner, W. Henry (Danville, CA)

    1999-01-01

    An ultra-high-mass time-of-flight mass spectrometer using a cryogenic particle detector as an ion detector with charge discriminating capabilities. Cryogenic detectors have the potential for significantly improving the performance and sensitivity of time-of-flight mass spectrometers, and compared to ion multipliers they exhibit superior sensitivity for high-mass, slow-moving macromolecular ions and can be used as "stop" detectors in time-of-flight applications. In addition, their energy resolving capability can be used to measure the charge state of the ions. Charge discrimination is very valuable in all time-of-flight mass spectrometers. Using a cryogenically-cooled Nb-Al.sub.2 O.sub.3 -Nb superconductor-insulator-superconductor (SIS) tunnel junction (STJ) detector operating at 1.3 K as an ion detector in a time-of-flight mass spectrometer for large biomolecules it was found that the STJ detector has charge discrimination capabilities. Since the cryogenic STJ detector responds to ion energy and does not rely on secondary electron production, as in the conventionally used microchannel plate (MCP) detectors, the cryogenic detector therefore detects large molecular ions with a velocity-independent efficiency approaching 100%.

  18. Elemental and isotopic analysis of inorganic salts by laser desorption ionization mass spectrometry

    SciTech Connect (OSTI)

    Jayasekharan, T.; Sahoo, N. K.

    2013-02-05

    Laser desorption ionization mass spectrometry is applied for the analysis of elements as well as their isotopic composition in different inorganic salts. At very low laser energies the inorganic ions are desorbed and ionized from the thin layer of the sample surface. The naturally occurring isotopes of alkali and silver ions are resolved using time of flight mass spectrometer. Further increase in laser energy shows the appearance of Al, Cr, and Fe ions in the mass spectra. This indicates the penetration laser beam beyond the sample surface leading to the ablation of sample target at higher energies. The simultaneous appearance of atomic ions from the sample target at relatively higher laser energies hampers the unambiguous identification of amino acid residues from the biomolecular ions in MALDI-MS.

  19. Imaging of Lipids and Metabolites Using Nanospray Desorption Electrospray Ionization Mass Spectrometry

    SciTech Connect (OSTI)

    Lanekoff, Ingela; Laskin, Julia

    2015-01-17

    In recent years, mass spectroscopy imaging (MSI) has emerged as a foundational technique in metabolomics and drug screening providing deeper understanding of complex mechanistic pathways within biochemical systems and biological organisms. We have been invited to contribute a chapter to a new Springer series volume, entitled “Mass Spectrometry Imaging of Small Molecules”. The volume is planned for the highly successful lab protocol series Methods in Molecular Biology, published by Humana Press, USA. The volume is aimed to equip readers with step-by-step mass spectrometric imaging protocols and bring rapidly maturing methods of MS imaging to life science researchers. The chapter will provide a detailed protocol of ambient MSI by use of nanospray desorption electrospray ionization.

  20. An Analysis of Nuclear Fuel Burnup in the AGR 1 TRISO Fuel Experiment Using Gamma Spectrometry, Mass Spectrometry, and Computational Simulation Techniques

    SciTech Connect (OSTI)

    Jason M. Harp; Paul A. Demkowicz; Phillip L. Winston; James W. Sterbentz

    2014-10-01

    AGR 1 was the first in a series of experiments designed to test US TRISO fuel under high temperature gas-cooled reactor irradiation conditions. This experiment was irradiated in the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL) and is currently undergoing post irradiation examination (PIE) at INL and Oak Ridge National Laboratory. One component of the AGR 1 PIE is the experimental evaluation of the burnup of the fuel by two separate techniques. Gamma spectrometry was used to non destructively evaluate the burnup of all 72 of the TRISO fuel compacts that comprised the AGR 1 experiment. Two methods for evaluating burnup by gamma spectrometry were developed, one based on the Cs 137 activity and the other based on the ratio of Cs 134 and Cs 137 activities. Burnup values determined from both methods compared well with the values predicted from simulations. The highest measured burnup was 20.1 %FIMA for the direct method and 20.0 %FIMA for the ratio method (compared to 19.56% FIMA from simulations). An advantage of the ratio method is that the burnup of the cylindrical fuel compacts can determined in small (2.5 mm) axial increments and an axial burnup profile can be produced. Destructive chemical analysis by inductively coupled mass spectrometry (ICP MS) was then performed on selected compacts that were representative of the expected range of fuel burnups in the experiment to compare with the burnup values determined by gamma spectrometry. The compacts analyzed by mass spectrometry had a burnup range of 19.3 % FIMA to 10.7 % FIMA. The mass spectrometry evaluation of burnup for the four compacts agreed well with the gamma spectrometry burnup evaluations and the expected burnup from simulation. For all four compacts analyzed by mass spectrometry, the maximum range in the three experimentally determined values and the predicted value was 6% or less. The results confirm the accuracy of the nondestructive burnup evaluation from gamma spectrometry for TRISO fuel compacts across a burnup range of approximately 10 to 20 % FIMA and also validate the approach used in the physics simulation of the AGR 1 experiment.

  1. Controlled-Resonant Surface Tapping-Mode Scanning Probe Electrospray Ionization Mass Spectrometry Imaging

    SciTech Connect (OSTI)

    Lorenz, Matthias; Ovchinnikova, Olga S; Kertesz, Vilmos; Van Berkel, Gary J

    2014-01-01

    This paper reports on the advancement of a controlled-resonance surface tapping-mode single capillary liquid junction extraction/ESI emitter for mass spectrometry imaging. The basic instrumental setup and the general operation of the system were discussed and optimized performance metrics were presented. The ability to spot sample, lane scan and chemically image in an automated and controlled fashion were demonstrated. Rapid, automated spot sampling was demonstrated for a variety of compound types including the cationic dye basic blue 7, the oligosaccharide cellopentaose, and the protein equine heart cytochrome c. The system was used for lane scanning and chemical imaging of the cationic dye crystal violet in inked lines on glass and for lipid distributions in mouse brain thin tissue sections. Imaging of the lipids in mouse brain tissue under optimized conditions provided a spatial resolution of approximately 35 m based on the ability to distinguish between features observed both in the optical and mass spectral chemical images. The sampling spatial resolution of this system was comparable to the best resolution that has been reported for other types of atmospheric pressure liquid extraction-based surface sampling/ionization techniques used for mass spectrometry imaging.

  2. 230Th-234U Age-Dating Uranium by Mass Spectrometry

    SciTech Connect (OSTI)

    Williams, R W; Gaffney, A M

    2012-04-18

    This is the standard operating procedure used by the Isotope Ratio Mass Spectrometry Group of the Chemical Sciences Division at LLNL for the preparation of a sample of uranium oxide or uranium metal for {sup 230}Th-{sup 234}U age-dating. The method described here includes the dissolution of a sample of uranium oxide or uranium metal, preparation of a secondary dilution, spiking of separate aliquots for uranium and thorium isotope dilution measurements, and purification of uranium and thorium aliquots for mass spectrometry. This SOP may be applied to uranium samples of unknown purity as in a nuclear forensic investigation, and also to well-characterized samples such as, for example, U{sub 3}O{sub 8} and U-metal certified reference materials. The sample of uranium is transferred to a quartz or PFA vial, concentrated nitric acid is added and the sample is heated on a hotplate at approximately 100 C for several hours until it dissolves. The sample solution is diluted with water to make the solution approximately 4 M HNO{sub 3} and hydrofluoric acid is added to make it 0.05 M HF. A secondary dilution of the primary uranium solution is prepared. Separate aliquots for uranium and thorium isotope dilution measurements are taken and spiked with {sup 233}U and {sup 229}Th, respectively. The spiked aliquot for uranium isotope dilution analysis is purified using EiChrom UTEVA resin. The spiked aliquot for thorium isotope dilution analysis is purified by, first, a 1.8 mL AG1x8 resin bed in 9 M HCl on which U adsorbs and Th passes through; second, adsorbing Th on a 1 mL AG1x8 resin bed in 8 M HNO{sub 3} and then eluting it with 9 M HCl followed by 0.1 M HCl + 0.005 M HF; and third, by passing the Th through a final 1.0 mL AG1x8 resin bed in 9 M HCl. The mass spectrometry is performed using the procedure 'Th and U Mass Spectrometry for {sup 230}Th-{sup 234}U Age Dating'.

  3. Analysis of volatile organic compounds in groundwater samples by gas chromatography-mass spectrometry

    SciTech Connect (OSTI)

    Bernhardt, J.

    1995-08-23

    The Savannah River Site contains approximately 1500 monitoring wells from which groundwater samples are collected. Many of these samples are sent off-site for various analyses, including the determination of trace volatile organic compounds (VOCs). This report describes accomplishments that have been made during the past year which will ultimately allow VOC analysis to be performed on-site using gas chromatography-mass spectrometry. Through the use of the on-site approach, it is expected that there will be a substantial cost savings. This approach will also provide split-sample analysis capability which can serve as a quality control measure for off-site analysis.

  4. Comparison of FTIR and Particle Mass Spectrometry for the Measurement of Paticulate Organic Nitrates

    SciTech Connect (OSTI)

    Bruns, Emily; Perraud, Veronique; Zelenyuk, Alla; Ezell, Michael J.; Johnson, Stanley N.; Yu, Yong; Imre, D.; Finlayson-Pitts, Barbara J.; Alexander, M. L.

    2010-02-01

    While multifunctional organic nitrates are formed during the atmospheric oxidation of volatile organic compounds, relatively little is known about their signatures in particle mass spectrometers. High resolution time-of-flight aerosol mass spectrometry (HR-ToF-AMS) was applied to NH4NO3, NaNO3 and isosorbide 5-mononitrate (IMN) particles, and to secondary organic aerosol (SOA) from NO3 radical reactions at 22 C and 1 atm in air with and pinene, 3-carene, limonene and isoprene. For comparison, single particle laser ablation mass spectra (SPLAT II) were also obtained for IMN and SOA from the pinene reaction. The mass spectra of all particles exhibit significant intensity at m/z 30, and for the SOA, weak peaks corresponding to various organic fragments containing nitrogen [CxHyNzOa]+ were identified using HR-ToF-AMS. The NO+/NO2+ ratios from HR-ToF-AMS were 10-15 for IMN and the SOA from the and pinene, 3-carene and limonene reactions, ~5 for the isoprene reaction, 2.4 for NH4NO3 and 80 for NaNO3. The N/H ratios from HR-ToF-AMS for the SOA were smaller by a factor of 2 to 4 than the -ONO2/C-H ratios measured using FTIR on particles impacted on ZnSe windows. While the NO+/NO2+ ratio may provide a generic indication of organic nitrates under some conditions, specific identification of particulate organic nitrates awaits further development of particle mass spectrometry techniques.

  5. An Open Port Sampling Interface for Liquid Introduction Atmospheric Pressure Ionization Mass Spectrometry

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Van Berkel, Gary J.; Kertesz, Vilmos

    2015-08-25

    RATIONALE: A simple method to introduce unprocessed samples into a solvent for rapid characterization by liquid introduction atmospheric pressure ionization mass spectrometry has been lacking. The continuous flow, self-cleaning open port sampling interface introduced here fills this void. METHODS: The open port sampling interface used a vertically aligned, co-axial tube arrangement enabling solvent delivery to the sampling end of the device through the tubing annulus and solvent aspiration down the center tube and into the mass spectrometer ionization source via the commercial APCI emitter probe. The solvent delivery rate to the interface was set to exceed the aspiration rate creatingmore » a continuous sampling interface along with a constant, self-cleaning spillover of solvent from the top of the probe. RESULTS: Using the open port sampling interface with positive ion mode APCI and a hybrid quadrupole time of flight mass spectrometer, rapid, direct sampling and analysis possibilities are exemplified with plastics, ballpoint and felt tip ink pens, skin, and vegetable oils. These results demonstrated that the open port sampling interface could be used as a simple, versatile and self-cleaning system to rapidly introduce multiple types of unprocessed, sometimes highly concentrated and complex, samples into a solvent flow stream for subsequent ionization and analysis by mass spectrometry. The basic setup presented here could be incorporated with any self-aspirating liquid introduction ionization source (e.g., ESI, APCI, APPI, ICP, etc.) or any type of atmospheric pressure sampling ready mass spectrometer system. CONCLUSIONS: The open port sampling interface provides a means to introduce and quickly analyze unprocessed solid or liquid samples with liquid introduction atmospheric pressure ionization source without fear of sampling interface or ionization source contamination.« less

  6. Multi-matrix, dual polarity, tandem mass spectrometry imaging strategy applied to a germinated maize seed: toward mass spectrometry imaging of an untargeted metabolome

    SciTech Connect (OSTI)

    Feenstra, Adam D.; Hansen, Rebecca L.; Lee, Young Jin

    2015-08-27

    Mass spectrometry imaging (MSI) provides high spatial resolution information that is unprecedented in traditional metabolomics analyses; however, the molecular coverage is often limited to a handful of compounds and is insufficient to understand overall metabolomic changes of a biological system. Here, we propose an MSI methodology to increase the diversity of chemical compounds that can be imaged and identified, in order to eventually perform untargeted metabolomic analysis using MSI. We use the desorption/ionization bias of various matrixes for different metabolite classes along with dual polarities and a tandem MSI strategy. The use of multiple matrixes and dual polarities allows us to visualize various classes of compounds, while data-dependent MS/MS spectra acquired in the same MSI scans allow us to identify the compounds directly on the tissue. In a proof of concept application to a germinated corn seed, a total of 166 unique ions were determined to have high-quality MS/MS spectra, without counting structural isomers, of which 52 were identified as unique compounds. According to an estimation based on precursor MSI datasets, we expect over five hundred metabolites could be potentially identified and visualized once all experimental conditions are optimized and an MS/MS library is available. Finally, metabolites involved in the glycolysis pathway and tricarboxylic acid cycle were imaged to demonstrate the potential of this technology to better understand metabolic biology.

  7. Multi-matrix, dual polarity, tandem mass spectrometry imaging strategy applied to a germinated maize seed: toward mass spectrometry imaging of an untargeted metabolome

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Feenstra, Adam D.; Hansen, Rebecca L.; Lee, Young Jin

    2015-08-27

    Mass spectrometry imaging (MSI) provides high spatial resolution information that is unprecedented in traditional metabolomics analyses; however, the molecular coverage is often limited to a handful of compounds and is insufficient to understand overall metabolomic changes of a biological system. Here, we propose an MSI methodology to increase the diversity of chemical compounds that can be imaged and identified, in order to eventually perform untargeted metabolomic analysis using MSI. We use the desorption/ionization bias of various matrixes for different metabolite classes along with dual polarities and a tandem MSI strategy. The use of multiple matrixes and dual polarities allows usmore » to visualize various classes of compounds, while data-dependent MS/MS spectra acquired in the same MSI scans allow us to identify the compounds directly on the tissue. In a proof of concept application to a germinated corn seed, a total of 166 unique ions were determined to have high-quality MS/MS spectra, without counting structural isomers, of which 52 were identified as unique compounds. According to an estimation based on precursor MSI datasets, we expect over five hundred metabolites could be potentially identified and visualized once all experimental conditions are optimized and an MS/MS library is available. Finally, metabolites involved in the glycolysis pathway and tricarboxylic acid cycle were imaged to demonstrate the potential of this technology to better understand metabolic biology.« less

  8. Cross-Linking and Mass Spectrometry Methodologies to Facilitate Structural Biology: Finding a Path through the Maze

    SciTech Connect (OSTI)

    Merkley, Eric D.; Cort, John R.; Adkins, Joshua N.

    2013-09-01

    Multiprotein complexes, rather than individual proteins, make up a large part of the biological macromolecular machinery of a cell. Understanding the structure and organization of these complexes is critical to understanding cellular function. Chemical cross-linking coupled with mass spectrometry is emerging as a complementary technique to traditional structural biology methods and can provide low-resolution structural information for a multitude of purposes, such as distance constraints in computational modeling of protein complexes. In this review, we discuss the experimental considerations for successful application of chemical cross-linking-mass spectrometry in biological studies and highlight three examples of such studies from the recent literature. These examples (as well as many others) illustrate the utility of a chemical cross-linking-mass spectrometry approach in facilitating structural analysis of large and challenging complexes.

  9. Analysis of fission gas release kinetics by on-line mass spectrometry

    SciTech Connect (OSTI)

    Zerega, Y.; Reynard-Carette, C.; Parrat, D.; Carette, M.; Brkic, B.; Lyoussi, A.; Bignan, G.; Janulyte, A.; Andre, J.; Pontillon, Y.; Ducros, G.; Taylor, S.

    2011-07-01

    The release of fission gas (Xe and Kr) and helium out of nuclear fuel materials in normal operation of a nuclear power reactor can constitute a strong limitation of the fuel lifetime. Moreover, radioactive isotopes of Xe and Kr contribute significantly to the global radiological source term released in the primary coolant circuit in case of accidental situations accompanied by fuel rod loss of integrity. As a consequence, fission gas release investigation is of prime importance for the nuclear fuel cycle economy, and is the driven force of numerous R and D programs. In this domain, for solving current fuel behavior understanding issues, preparing the development of new fuels (e.g. for Gen IV power systems) and for improving the modeling prediction capability, there is a marked need for innovations in the instrumentation field, mainly for: . Quantification of very low fission gas concentrations, released from fuel sample and routed in sweeping lines. Monitoring of quick gas release variations by quantification of elementary release during a short period of time. Detection of a large range of atomic masses (e.g. H{sub 2}, HT, He, CO, CO{sub 2}, Ne, Ar, Kr, Xe), together with a performing separation of isotopes for Xe and Kr elements. Coupling measurement of stable and radioactive gas isotopes, by using in parallel mass spectrometry and gamma spectrometry techniques. To fulfill these challenging needs, a common strategy for analysis equipment implementation has been set up thanks to a recently launched collaboration between the CEA and the Univ. of Provence, with the technological support of the Liverpool Univ.. It aims at developing a chronological series of mass spectrometer devices based upon mass filter and 2D/3D ion traps with Fourier transform operating mode and having increasing levels of performances to match the previous challenges for out-of pile and in-pile experiments. The final objective is to install a high performance online mass spectrometer coupled to a gamma spectrometer in the fission product laboratory of the future Jules Horowitz Material Test Reactor. An intermediate step will consist of testing first equipment on an existing experimental facility in the LECA-STAR Hot Cell Laboratory of the CEA Cadarache. This paper presents the scientific and operational stakes linked to fission gas issues, resumes the current state of art for analyzing them in nuclear facilities, then presents the skills gathered through this collaboration to overcome technological bottlenecks. Finally it describes the implementation strategy in nuclear research facilities of the CEA Cadarache. (authors)

  10. MAINTAINING HIGH RESOLUTION MASS SPECTROMETRY CAPABILITIES FOR NATIONAL NUCLEAR SECURITY ADMINISTRATION APPLICATIONS

    SciTech Connect (OSTI)

    Wyrick, S.; Cordaro, J.; Reeves, G.; Mcintosh, J.; Mauldin, C.; Tietze, K.; Varble, D.

    2011-06-06

    The Department of Energy (DOE) National Nuclear Security Administration (NNSA) has a specialized need for analyzing low mass gas species at very high resolutions. The currently preferred analytical method is electromagnetic sector mass spectrometry. This method allows the NNSA Nuclear Security Enterprise (NSE) to resolve species of similar masses down to acceptable minimum detection limits (MDLs). Some examples of these similar masses are helium-4/deuterium and carbon monoxide/nitrogen. Through the 1980s and 1990s, there were two vendors who supplied and supported these instruments. However, with declining procurements and down turns in the economy, the supply of instruments, service and spare parts from these vendors has become less available, and in some cases, nonexistent. The largest NSE user of this capability is the Savannah River Site (SRS), located near Aiken, South Carolina. The Research and Development Engineering (R&DE) Group in the Savannah River National Laboratory (SRNL) investigated the areas of instrument support that were needed to extend the life cycle of these aging instruments. Their conclusions, as to the focus areas of electromagnetic sector mass spectrometers to address, in order of priority, were electronics, software and hardware. Over the past 3-5 years, the R&DE Group has designed state of the art electronics and software that will allow high resolution legacy mass spectrometers, critical to the NNSA mission, to be operated for the foreseeable future. The funding support for this effort has been from several sources, including the SRS Defense Programs, NNSA Readiness Campaign, Pantex Plant and Sandia National Laboratory. To date, electronics systems have been upgraded on one development system at SRNL, two production systems at Pantex and one production system at Sandia National Laboratory. An NSE working group meets periodically to review strategies going forward. The R&DE Group has also applied their work to the electronics for a Thermal Ionization Mass Spectrometer (TIMS) instrument, which applies a similar mass spectrometric technology for resolving high mass isotopes, such as plutonium and uranium. Due to non-compete clauses for DOE, all work has been performed and applied to instruments which are obsolete and are no longer supported by the original vendor.

  11. A Hybrid Approach to Protein Differential Expression in Mass Spectrometry-Based Proteomics

    SciTech Connect (OSTI)

    Wang, Xuan; Anderson, Gordon A.; Smith, Richard D.; Dabney, Alan R.

    2012-04-19

    Motivation: Quantitative mass spectrometry-based proteomics involves statistical inference on protein abundance, based on the intensities of each protein's associated spectral peaks. However, typical MS-based proteomics data sets have substantial proportions of missing observations, due at least in part to censoring of low intensities. This complicates intensity-based differential expression analysis. Results: We outline a statistical method for protein differential expression, based on a simple Binomial likelihood. By modeling peak intensities as binary, in terms of 'presence/ absence,' we enable the selection of proteins not typically amendable to quantitative analysis; e.g., 'one-state' proteins that are present in one condition but absent in another. In addition, we present an analysis protocol that combines quantitative and presence/ absence analysis of a given data set in a principled way, resulting in a single list of selected proteins with a single associated FDR.

  12. Detecting and Removing Data Artifacts in Hadamard Transform Ion Mobility-Mass Spectrometry Measurements

    SciTech Connect (OSTI)

    Prost, Spencer A.; Crowell, Kevin L.; Baker, Erin Shammel; Ibrahim, Yehia M.; Clowers, Brian H.; Monroe, Matthew E.; Anderson, Gordon A.; Smith, Richard D.; Payne, Samuel H.

    2014-12-01

    Applying Hadamard transform multiplexing to ion mobility separations (IMS) can significantly improve the signal-to-noise ratio and throughput for IMS coupled mass spectrometry (MS) measurements by increasing the ion utilization efficiency. However, it has been determined that both fluctuations in ion intensity as well as spatial shifts in the multiplexed data lower the signal-to-noise ratios and appear as noise in downstream processing of the data. To address this problem, we have developed a novel algorithm that discovers and eliminates data artifacts. The algorithm uses knowledge of the true signal peaks derived from the encoded data and allows for both artifacts and noise to be removed with high confidence, decreasing the likelihood of false identifications in subsequent data processing. The result is that IMS-MS can be applied to increase measurement sensitivity while avoiding artifacts that have previously limited its utility.

  13. Detonation reaction steps frozen by free expansion and analyzed by mass spectrometry

    SciTech Connect (OSTI)

    Greiner, N.R.; Fry, H.A.; Blais, N.C.; Engelke, R.P.

    1993-05-01

    Detonation reactions in small pellets of explosive are frozen by free expansion into a large vacuum chamber and analyzed by time-of-flight mass spectrometry. Sensitive explosives like PETN, RDX, and HMX show rapidly evolving reaction zones and mostly simple products like H{sub 2}O, CO, N{sub 2}, and CO{sub 2}. Less sensitive explosives like TATB, HNS, and TNT show slower evolution of the reaction zone, and more complex products in addition to the simple ones seen in PETN. Isotopic substitution shows that the more complex products contain moderate amounts of NH{sub 3}, HCN, NO, HNCO, and NO{sub 2}. Other observations include polymerization of aromatic explosive molecules, adducts to the explosive molecules, and explosive molecules with functional groups missing. The more complex products are reservoirs of unreleased energy that may affect performance.

  14. Detonation reaction steps frozen by free expansion and analyzed by mass spectrometry

    SciTech Connect (OSTI)

    Greiner, N.R.; Fry, H.A.; Blais, N.C.; Engelke, R.P.

    1993-01-01

    Detonation reactions in small pellets of explosive are frozen by free expansion into a large vacuum chamber and analyzed by time-of-flight mass spectrometry. Sensitive explosives like PETN, RDX, and HMX show rapidly evolving reaction zones and mostly simple products like H[sub 2]O, CO, N[sub 2], and CO[sub 2]. Less sensitive explosives like TATB, HNS, and TNT show slower evolution of the reaction zone, and more complex products in addition to the simple ones seen in PETN. Isotopic substitution shows that the more complex products contain moderate amounts of NH[sub 3], HCN, NO, HNCO, and NO[sub 2]. Other observations include polymerization of aromatic explosive molecules, adducts to the explosive molecules, and explosive molecules with functional groups missing. The more complex products are reservoirs of unreleased energy that may affect performance.

  15. Membrane-Based Emitter for Coupling Microfluidics with Ultrasensitive Nanoelectrospray Ionization-Mass Spectrometry

    SciTech Connect (OSTI)

    Sun, Xuefei; Kelly, Ryan T.; Tang, Keqi; Smith, Richard D.

    2011-06-09

    An integrated poly(dimethylsiloxane) (PDMS) membrane-based microfluidic emitter for high performance nanoelectrospray ionization-mass spectrometry (nanoESI-MS) has been fabricated and evaluated. The ~100-?m-thick emitter was created by cutting a PDMS membrane that protrudes beyond the bulk substrate. The reduced surface area at the emitter enhances the electric field and reduces wetting of the surface by the electrospray solvent. As such, the emitter provides highly stable electrospray at flow rates as low as 10 nL/min, and is compatible with electrospray solvents containing a large organic component (e.g., 90% methanol). This approach enables facile emitter construction, and provides excellent stability, reproducibility and sensitivity, as well as compatibility with multilayer soft lithography.

  16. Synchrotron photoionization mass spectrometry study of intermediates in fuel-rich 1,2-dimethoxyethane flame

    SciTech Connect (OSTI)

    Lin, Z. K.; Han, D. L.; Li, S. F.; Li, Y. Y.; Yuan, T.

    2009-04-21

    Intermediates in a fuel-rich premixed laminar 1,2-dimethoxyethane (DME) flame are studied by molecular beam mass spectrometry combined with tunable synchrotron vacuum ultraviolet photoionization. About 30 intermediate species are identified in the present work, and their mole fraction profiles are evaluated. The experimental results show that the formations of intermediates, both hydrocarbons and oxygenated hydrocarbons, are closely linked to the structure of fuel, which is consistent with the previous reports. Species produced from H atom abstraction and beta scission of DME usually have much higher concentrations than others. The oxygen atoms in DME are considered to act as partitions of the primary intermediates; therefore farther reactions among these primary intermediates are difficult to occur, resulting in absence of most large intermediate species.

  17. Shotgun Approach for Quantitative Imaging of Phospholipids Using Nanospray Desorption Electrospray Ionization Mass Spectrometry

    SciTech Connect (OSTI)

    Lanekoff, Ingela T.; Thomas, Mathew; Laskin, Julia

    2014-02-04

    Mass spectrometry imaging (MSI) has been extensively used for determining spatial distributions of molecules in biological samples, and there is increasing interest in using MSI for quantification. Nanospray desorption electrospray ionization, or nano-DESI, is an ambient MSI technique where a solvent is used for localized extraction of molecules followed by nanoelectrospray ionization. Doping the nano-DESI solvent with carefully selected standards enables online quantification during MSI experiments. In this proof-of-principle study, we demonstrate this quantification approach can be extended to provide shotgun-like quantification of phospholipids in thin brain tissue sections. Specifically, two phosphatidylcholine (PC) standards were added to the nano-DESI solvent for simultaneous imaging and quantification of 22 PC species observed in nano-DESI MSI. Furthermore, by combining the quantitative data obtained in the individual pixels, we demonstrate quantification of these PC species in seven different regions of a rat brain tissue section.

  18. Laser Desorption Postionization Mass Spectrometry of Antibiotic-Treated Bacterial Biofilms using Tunable Vacuum Ultraviolet Radiation

    SciTech Connect (OSTI)

    Gasper, Gerald L.; Takahashi, Lynelle K.; Zhou, Jia; Ahmed, Musahid; Moore, Jerry F.; Hanley, Luke

    2010-08-04

    Laser desorption postionization mass spectrometry (LDPI-MS) with 8.0 ? 12.5 eV vacuum ultraviolet synchrotron radiation is used to single photon ionize antibiotics andextracellular neutrals that are laser desorbed both neat and from intact bacterial biofilms. Neat antibiotics are optimally detected using 10.5 eV LDPI-MS, but can be ionized using 8.0 eV radiation, in agreement with prior work using 7.87 eV LDPI-MS. Tunable vacuum ultraviolet radiation also postionizes laser desorbed neutrals of antibiotics and extracellular material from within intact bacterial biofilms. Different extracellular material is observed by LDPI-MS in response to rifampicin or trimethoprim antibiotic treatment. Once again, 10.5 eV LDPI-MS displays the optimum trade-off between improved sensitivity and minimum fragmentation. Higher energy photons at 12.5 eV produce significant parent ion signal, but fragment intensity and other low mass ions are also enhanced. No matrix is added to enhance desorption, which is performed at peak power densities insufficient to directly produce ions, thus allowing observation of true VUV postionization mass spectra of antibiotic treated biofilms.

  19. Laser desorption time-of-flight mass spectrometry of ultraviolet photo-processed ices

    SciTech Connect (OSTI)

    Paardekooper, D. M. Bossa, J.-B.; Isokoski, K.; Linnartz, H.

    2014-10-01

    A new ultra-high vacuum experiment is described that allows studying photo-induced chemical processes in interstellar ice analogues. MATRI²CES - a Mass Analytical Tool to study Reactions in Interstellar ICES applies a new concept by combining laser desorption and time-of-flight mass spectrometry with the ultimate goal to characterize in situ and in real time the solid state evolution of organic compounds upon UV photolysis for astronomically relevant ice mixtures and temperatures. The performance of the experimental setup is demonstrated by the kinetic analysis of the different photoproducts of pure methane (CH?) ice at 20 K. A quantitative approach provides formation yields of several new species with up to four carbon atoms. Convincing evidence is found for the formation of even larger species. Typical mass resolutions obtained range from M/?M ~320 to ~400 for CH? and argon, respectively. Additional tests show that the typical detection limit (in monolayers) is ?0.02 ML, substantially more sensitive than the regular techniques used to investigate chemical processes in interstellar ices.

  20. Structural Analysis of a Highly Glycosylated and Unliganded gp120-Based Antigen Using Mass Spectrometry

    SciTech Connect (OSTI)

    L Wang; Y Qin; S Ilchenko; J Bohon; W Shi; M Cho; K Takamoto; M Chance

    2011-12-31

    Structural characterization of the HIV-1 envelope protein gp120 is very important for providing an understanding of the protein's immunogenicity and its binding to cell receptors. So far, the crystallographic structure of gp120 with an intact V3 loop (in the absence of a CD4 coreceptor or antibody) has not been determined. The third variable region (V3) of the gp120 is immunodominant and contains glycosylation signatures that are essential for coreceptor binding and entry of the virus into T-cells. In this study, we characterized the structure of the outer domain of gp120 with an intact V3 loop (gp120-OD8) purified from Drosophila S2 cells utilizing mass spectrometry-based approaches. We mapped the glycosylation sites and calculated the glycosylation occupancy of gp120-OD8; 11 sites from 15 glycosylation motifs were determined as having high-mannose or hybrid glycosylation structures. The specific glycan moieties of nine glycosylation sites from eight unique glycopeptides were determined by a combination of ECD and CID MS approaches. Hydroxyl radical-mediated protein footprinting coupled with mass spectrometry analysis was employed to provide detailed information about protein structure of gp120-OD8 by directly identifying accessible and hydroxyl radical-reactive side chain residues. Comparison of gp120-OD8 experimental footprinting data with a homology model derived from the ligated CD4-gp120-OD8 crystal structure revealed a flexible V3 loop structure in which the V3 tip may provide contacts with the rest of the protein while residues in the V3 base remain solvent accessible. In addition, the data illustrate interactions between specific sugar moieties and amino acid side chains potentially important to the gp120-OD8 structure.

  1. Spatially tracking 13C labeled substrate (bicarbonate) accumulation in microbial communities using laser ablation isotope ratio mass spectrometry

    SciTech Connect (OSTI)

    Moran, James J.; Doll, Charles G.; Bernstein, Hans C.; Renslow, Ryan S.; Cory, Alexandra B.; Hutchison, Janine R.; Lindemann, Stephen R.; Fredrickson, Jim K.

    2014-08-25

    This is a manuscript we would like to submit for publication in Environmental Microbiology Reports. This manuscript contains a description of a laser ablation isotope ratio mass spectrometry methodology developed at PNNL and applied to a microbial system at a PNNL project location – Hot Lake, Washington. I will submit a word document containing the entire manuscript with this Erica input request form.

  2. Topographical and Chemical Imaging of a Phase Separated Polymer Using a Combined Atomic Force Microscopy/Infrared Spectroscopy/Mass Spectrometry Platform

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Tai, Tamin; Karácsony, Orsolya; Bocharova, Vera; Van Berkel, Gary J.; Kertesz, Vilmos

    2016-02-18

    This article describes how the use of a hybrid atomic force microscopy/infrared spectroscopy/mass spectrometry imaging platform was demonstrated for the acquisition and correlation of nanoscale sample surface topography and chemical images based on infrared spectroscopy and mass spectrometry.

  3. Wall loss of atomic nitrogen determined by ionization threshold mass spectrometry

    SciTech Connect (OSTI)

    Sode, M. Schwarz-Selinger, T.; Jacob, W.; Kersten, H.

    2014-11-21

    In the afterglow of an inductively coupled N{sub 2} plasma, relative N atom densities are measured by ionization threshold mass spectrometry as a function of time in order to determine the wall loss time t{sub wN} from the exponential decay curves. The procedure is performed with two mass spectrometers on different positions in the plasma chamber. t{sub wN} is determined for various pressures, i.e., for 3.0, 5.0, 7.5, and 10?Pa. For this conditions also the internal plasma parameters electron density n{sub e} and electron temperature T{sub e} are determined with the Langmuir probe and the rotational temperature T{sub rot}{sup N{sub 2}} of N{sub 2} is determined with the optical emission spectroscopy. For T{sub rot}{sup N{sub 2}}, a procedure is presented to evaluate the spectrum of the transition ?{sup ?}=0??{sup ?}=2 of the second positive system (C{sup 3}?{sub u}?B{sup 3}?{sub g}) of N{sub 2}. With this method, a gas temperature of 610?K is determined. For both mass spectrometers, an increase of the wall loss times of atomic nitrogen with increasing pressure is observed. The wall loss time measured with the first mass spectrometer in the radial center of the cylindrical plasma vessel increases linearly from 0.31?ms for 3?Pa to 0.82?ms for 10?Pa. The wall loss time measured with the second mass spectrometer (further away from the discharge) is about 4 times higher. A model is applied to describe the measured t{sub wN.} The main loss mechanism of atomic nitrogen for the considered pressure is diffusion to the wall. The surface loss probability ?{sub N} of atomic nitrogen on stainless steel was derived from t{sub wN} and is found to be 1 for the present conditions. The difference in wall loss times measured with the mass spectrometers on different positions in the plasma chamber is attributed to the different diffusion lengths.

  4. Electron Flood Charge Compensation Device for Ion Trap Secondary Ion Mass Spectrometry

    SciTech Connect (OSTI)

    Appelhans, Anthony David; Ward, Michael Blair; Olson, John Eric

    2002-11-01

    During secondary ion mass spectrometry (SIMS) analyses of organophosphorous compounds adsorbed onto soils, the measured anion signals were lower than expected and it was hypothesized that the low signals could be due to sample charging. An electron flood gun was designed, constructed and used to investigate sample charging of these and other sample types. The flood gun was integrated into one end cap of an ion trap secondary ion mass spectrometer and the design maintained the geometry of the self-stabilizing extraction optics used in this instrument. The SIMION ion optics program was used to design the flood gun, and experimental results agreed with the predicted performance. Results showed the low anion signals from the soils were not due to sample charging. Other insulating and conducting samples were tested using both a ReO4- and a Cs+ primary ion beam. The proximity of the sample and electron source to the ion trap aperture resulted in generation of background ions in the ion trap via electron impact (EI) ionization during the period the electron gun was flooding the sample region. When using the electron gun with the ReO4- primary beam, the required electron current was low enough that the EI background was negligible; however, the high electron flood current required with the Cs+ beam produced background EI ions that degraded the quality of the mass spectra. The consequences of the EI produced cations will have to be evaluated on a sample-by-sample basis when using electron flood. It was shown that the electron flood gun could be intentionally operated to produce EI spectra in this instrument. This offers the opportunity to measure, nearly simultaneously, species evaporating from a sample, via EI, and species bound to the surface, via SIMS.

  5. OBSERVATION OF HEATING BY FLARE-ACCELERATED ELECTRONS IN A SOLAR CORONAL MASS EJECTION

    SciTech Connect (OSTI)

    Glesener, Lindsay; Bain, Hazel M.; Krucker, Säm; Lin, Robert P.

    2013-12-20

    We report a Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI) observation of flare-accelerated electrons in the core of a coronal mass ejection (CME) and examine their role in heating the CME. Previous CME observations have revealed remarkably high thermal energies that can far surpass the CME's kinetic energy. A joint observation by RHESSI and the Atmospheric Imaging Assembly of a partly occulted flare on 2010 November 3 allows us to test the hypothesis that this excess energy is collisionally deposited by flare-accelerated electrons. Extreme ultraviolet (EUV) images show an ejection forming the CME core and sheath, with isothermal multifilter analysis revealing temperatures of ?11 MK in the core. RHESSI images reveal a large (?100 × 50 arcsec{sup 2}) hard X-ray (HXR) source matching the location, shape, and evolution of the EUV plasma, indicating that the emerging CME is filled with flare-accelerated electrons. The time derivative of the EUV emission matches the HXR light curve (similar to the Neupert effect observed in soft and HXR time profiles), directly linking the CME temperature increase with the nonthermal electron energy loss, while HXR spectroscopy demonstrates that the nonthermal electrons contain enough energy to heat the CME. This is the most direct observation to date of flare-accelerated electrons heating a CME, emphasizing the close relationship of the two in solar eruptive events.

  6. Accelerator Mass Spectrometry | U.S. DOE Office of Science (SC...

    Office of Science (SC) Website

    ... An important application of AMS measurements of the naturally occurring 36ClCl ratio in water (as opposed to the one created by atmospheric and underground nuclear weapons test) ...

  7. Ultra-Sensitive Measurements of 233U by Accelerator Mass Spectrometry for National Security Applications.

    SciTech Connect (OSTI)

    Tumey, S J; Brown, T A; Buchholz, B A; Hamilton, T F; Hutcheon, I D; Williams, R W

    2009-07-13

    By making modifications to our previously established measurement setup, we increased our abundance sensitivity for {sup 233}U by three orders of magnitude and can now measure {sup 233}U/{sup 238}U ratios as low as 10{sup -13}. Because {sup 233}U has separate production pathways than {sup 236}U, it can provide valuable information on the particular source of anthropogenic uranium in a sample. We demonstrated the utility of our improved capability by using {sup 233}U to distinguish separate sources of anthropogenic uranium in a set of samples collected from a contaminated site. In the future, we plan to apply our new capability to characterizing {sup 233}U in a wide range of uranium materials.

  8. Indexing Permafrost Soil Organic Matter Degradation Using High-Resolution Mass Spectrometry

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Mann, Benjamin F.; Chen, Hongmei; Herndon, Elizabeth M.; Chu, Rosalie K.; Tolic, Nikola; Portier, Evan F.; Roy Chowdhury, Taniya; Robinson, Errol W.; Callister, Stephen J.; Wullschleger, Stan D.; et al

    2015-06-12

    Microbial degradation of soil organic matter (SOM) is a key process for terrestrial carbon cycling, although the molecular details of these transformations remain unclear. This study reports the application of ultrahigh resolution mass spectrometry to profile the molecular composition of SOM and its degradation during a simulated warming experiment. A soil sample, collected near Barrow, Alaska, USA, was subjected to a 40-day incubation under anoxic conditions and analyzed before and after the incubation to determine changes of SOM composition. A CHO index based on molecular C, H, and O data was utilized to codify SOM components according to their observedmore » degradation potentials. Compounds with a CHO index score between –1 and 0 in a water-soluble fraction (WSF) demonstrated high degradation potential, with a highest shift of CHO index occurred in the N-containing group of compounds, while similar stoichiometries in a base-soluble fraction (BSF) did not. Additionally, compared with the classical H:C vs O:C van Krevelen diagram, CHO index allowed for direct visualization of the distribution of heteroatoms such as N in the identified SOM compounds. We demonstrate that CHO index is useful not only in characterizing arctic SOM at the molecular level but also enabling quantitative description of SOM degradation, thereby facilitating incorporation of the high resolution MS datasets to future mechanistic models of SOM degradation and prediction of greenhouse gas emissions.« less

  9. Characterization of Interlayer Cs+ in Clay Samples Using Secondary Ion Mass Spectrometry with Laser Sample Modification

    SciTech Connect (OSTI)

    G. S. Groenewold; R. Avci; C. Karahan; K. Lefebre; R. V. Fox; M. M. Cortez; A. K. Gianotto; J. Sunner; W. L. Manner

    2004-04-01

    Ultraviolet laser irradiation was used to greatly enhance the secondary ion mass spectrometry (SIMS) detection of Cs+ adsorbed to soil consisting of clay and quartz. Imaging SIMS showed that the enhancement of the Cs+ signal was spatially heterogeneous: the intensity of the Cs+ peak was increased by factors up to 100 for some particles but not at all for others. Analysis of standard clay samples exposed to Cs+ showed a variable response to laser irradiation depending on the type of clay analyzed. The Cs+ abundance was significantly enhanced when Cs+-exposed montmorillonite was irradiated and then analyzed using SIMS, which contrasted with the behavior of Cs+-exposed kaolinite, which displayed no Cs+ enhancement. Exposed illitic clays displayed modest enhancement of Cs+ upon laser irradiation, intermediate between that of kaolinite and montmorillonite. The results for Cs+ were rationalized in terms of adsorption to interlayer sites within the montmorillonite, which is an expandable phyllosilicate. In these locations, Cs+ was not initially detectable using SIMS. Upon irradiation, Cs+ was thermally redistributed, which enabled detection using SIMS. Since neither the illite nor the kaolinite is an expandable clay, adsorption to inner-layer sites does not occur, and either modest or no laser enhancement of the Cs+ signal is observed. Laser irradiation also produced unexpected enhancement of Ti+ from illite and kaolinite clays that contained small quantities of Ti, which indicates the presence of microscopic titanium oxide phases in the clay materials.

  10. Femtosecond laser ablation-based mass spectrometry. An ideal tool for stoichiometric analysis of thin films

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    LaHaye, Nicole L.; Kurian, Jose; Diwakar, Prasoon K.; Alff, Lambert; Harilal, Sivanandan S.

    2015-08-19

    An accurate and routinely available method for stoichiometric analysis of thin films is a desideratum of modern materials science where a material’s properties depend sensitively on elemental composition. We thoroughly investigated femtosecond laser ablation-inductively coupled plasma-mass spectrometry (fs-LA-ICP-MS) as an analytical technique for determination of the stoichiometry of thin films down to the nanometer scale. The use of femtosecond laser ablation allows for precise removal of material with high spatial and depth resolution that can be coupled to an ICP-MS to obtain elemental and isotopic information. We used molecular beam epitaxy-grown thin films of LaPd(x)Sb2 and T´-La2CuO4 to demonstrate themore » capacity of fs-LA-ICP-MS for stoichiometric analysis and the spatial and depth resolution of the technique. Here we demonstrate that the stoichiometric information of thin films with a thickness of ~10 nm or lower can be determined. Furthermore, our results indicate that fs-LA-ICP-MS provides precise information on the thin film-substrate interface and is able to detect the interdiffusion of cations.« less

  11. Indexing Permafrost Soil Organic Matter Degradation Using High-Resolution Mass Spectrometry

    SciTech Connect (OSTI)

    Mann, Benjamin F.; Chen, Hongmei; Herndon, Elizabeth M.; Chu, Rosalie K.; Tolic, Nikola; Portier, Evan F.; Roy Chowdhury, Taniya; Robinson, Errol W.; Callister, Stephen J.; Wullschleger, Stan D.; Graham, David E.; Liang, Liyuan; Gu, Baohua; Hui, Dafeng

    2015-06-12

    Microbial degradation of soil organic matter (SOM) is a key process for terrestrial carbon cycling, although the molecular details of these transformations remain unclear. This study reports the application of ultrahigh resolution mass spectrometry to profile the molecular composition of SOM and its degradation during a simulated warming experiment. A soil sample, collected near Barrow, Alaska, USA, was subjected to a 40-day incubation under anoxic conditions and analyzed before and after the incubation to determine changes of SOM composition. A CHO index based on molecular C, H, and O data was utilized to codify SOM components according to their observed degradation potentials. Compounds with a CHO index score between –1 and 0 in a water-soluble fraction (WSF) demonstrated high degradation potential, with a highest shift of CHO index occurred in the N-containing group of compounds, while similar stoichiometries in a base-soluble fraction (BSF) did not. Additionally, compared with the classical H:C vs O:C van Krevelen diagram, CHO index allowed for direct visualization of the distribution of heteroatoms such as N in the identified SOM compounds. We demonstrate that CHO index is useful not only in characterizing arctic SOM at the molecular level but also enabling quantitative description of SOM degradation, thereby facilitating incorporation of the high resolution MS datasets to future mechanistic models of SOM degradation and prediction of greenhouse gas emissions.

  12. Laser-Induced Ionization Efficiency Enhancement On A Filament For Thermal Ionization Mass Spectrometry

    SciTech Connect (OSTI)

    Siegfried, M.

    2015-10-14

    The evaluation of trace Uranium and Plutonium isotope ratios for nanogram to femtogram material quantities is a vital tool for nuclear counter-proliferation and safeguard activities. Thermal Ionization Mass Spectrometry (TIMS) is generally accepted as the state of the art technology for highly accurate and ultra-trace measurements of these actinide ratios. However, the very low TIMS ionization yield (typically less than 1%) leaves much room for improvement. Enhanced ionization of Nd and Sm from a TIMS filament was demonstrated using wavelength resonance with a nanosecond (pulse width) laser operating at 10 Hz when light was directed toward the filament.1 For this study, femtosecond and picosecond laser capabilities were to be employed to study the dissociation and ionization mechanisms of actinides/lanthanides and measure the enhanced ionization of the metal of interest. Since the underlying chemistry of the actinide/lanthanide carbides produced and dissociated on a TIMS filament is not well understood, the experimental parameters affecting the photodissociation and photoionization with one and two laser beams were to be investigated.

  13. Femtosecond laser ablation-based mass spectrometry. An ideal tool for stoichiometric analysis of thin films

    SciTech Connect (OSTI)

    LaHaye, Nicole L.; Kurian, Jose; Diwakar, Prasoon K.; Alff, Lambert; Harilal, Sivanandan S.

    2015-08-19

    An accurate and routinely available method for stoichiometric analysis of thin films is a desideratum of modern materials science where a material’s properties depend sensitively on elemental composition. We thoroughly investigated femtosecond laser ablation-inductively coupled plasma-mass spectrometry (fs-LA-ICP-MS) as an analytical technique for determination of the stoichiometry of thin films down to the nanometer scale. The use of femtosecond laser ablation allows for precise removal of material with high spatial and depth resolution that can be coupled to an ICP-MS to obtain elemental and isotopic information. We used molecular beam epitaxy-grown thin films of LaPd(x)Sb2 and T´-La2CuO4 to demonstrate the capacity of fs-LA-ICP-MS for stoichiometric analysis and the spatial and depth resolution of the technique. Here we demonstrate that the stoichiometric information of thin films with a thickness of ~10 nm or lower can be determined. Furthermore, our results indicate that fs-LA-ICP-MS provides precise information on the thin film-substrate interface and is able to detect the interdiffusion of cations.

  14. Systematic Optimization of Long Gradient Chromatography Mass Spectrometry for Deep Analysis of Brain Proteome

    SciTech Connect (OSTI)

    Wang, Hong; Yang, Yanling; Li, Yuxin; Bai, Bing; Wang, Xusheng; Tan, Haiyan; Liu, Tao; Beach, Thomas G.; Peng, Junmun; Wu, Zhiping

    2015-02-06

    Development of high resolution liquid chromatography (LC) is essential for improving the sensitivity and throughput of mass spectrometry (MS)-based proteomics. Here we present systematic optimization of a long gradient LC-MS/MS platform to enhance protein identification from a complex mixture. The platform employed an in-house fabricated, reverse phase column (100 μm x 150 cm) coupled with Q Exactive MS. The column was capable of achieving a peak capacity of approximately 700 in a 720 min gradient of 10-45% acetonitrile. The optimal loading level was about 6 micrograms of peptides, although the column allowed loading as many as 20 micrograms. Gas phase fractionation of peptide ions further increased the number of peptide identification by ~10%. Moreover, the combination of basic pH LC pre-fractionation with the long gradient LC-MS/MS platform enabled the identification of 96,127 peptides and 10,544 proteins at 1% protein false discovery rate in a postmortem brain sample of Alzheimer’s disease. As deep RNA sequencing of the same specimen suggested that ~16,000 genes were expressed, current analysis covered more than 60% of the expressed proteome. Further improvement strategies of the LC/LC-MS/MS platform were also discussed.

  15. Imaging Nicotine in Rat Brain Tissue by Use of Nanospray Desorption Electrospray Ionization Mass Spectrometry

    SciTech Connect (OSTI)

    Lanekoff, Ingela T.; Thomas, Mathew; Carson, James P.; Smith, Jordan N.; Timchalk, Charles; Laskin, Julia

    2013-01-15

    Imaging mass spectrometry offers simultaneous detection of drugs, drug metabolites and endogenous substances in a single experiment. This is important when evaluating effects of a drug on a complex organ system such as the brain, where there is a need to understand how regional drug distribution impacts function. Nicotine is an addictive drug and its action in the brain is of high interest. Here we use nanospray desorption electrospray ionization, nano-DESI, imaging to discover the localization of nicotine in rat brain tissue after in vivo administration of nicotine. Nano-DESI is a new ambient technique that enables spatially-resolved analysis of tissue samples without special sample pretreatment. We demonstrate high sensitivity of nano-DESI imaging that enables detection of only 0.7 fmole nicotine per pixel in the complex brain matrix. Furthermore, by adding deuterated nicotine to the solvent, we examined how matrix effects, ion suppression, and normalization affect the observed nicotine distribution. Finally, we provide preliminary results suggesting that nicotine localizes to the hippocampal substructure called dentate gyrus.

  16. IMPULSIVE ACCELERATION OF CORONAL MASS EJECTIONS. II. RELATION TO SOFT X-RAY FLARES AND FILAMENT ERUPTIONS

    SciTech Connect (OSTI)

    Bein, B. M.; Berkebile-Stoiser, S.; Veronig, A. M.; Temmer, M.; Vrsnak, B.

    2012-08-10

    Using high time cadence images from the STEREO EUVI, COR1, and COR2 instruments, we derived detailed kinematics of the main acceleration stage for a sample of 95 coronal mass ejections (CMEs) in comparison with associated flares and filament eruptions. We found that CMEs associated with flares reveal on average significantly higher peak accelerations and lower acceleration phase durations, initiation heights, and heights, at which they reach their peak velocities and peak accelerations. This means that CMEs that are associated with flares are characterized by higher and more impulsive accelerations and originate from lower in the corona where the magnetic field is stronger. For CMEs that are associated with filament eruptions we found only for the CME peak acceleration significantly lower values than for events that were not associated with filament eruptions. The flare rise time was found to be positively correlated with the CME acceleration duration and negatively correlated with the CME peak acceleration. For the majority of the events the CME acceleration starts before the flare onset (for 75% of the events) and the CME acceleration ends after the soft X-ray (SXR) peak time (for 77% of the events). In {approx}60% of the events, the time difference between the peak time of the flare SXR flux derivative and the peak time of the CME acceleration is smaller than {+-}5 minutes, which hints at a feedback relationship between the CME acceleration and the energy release in the associated flare due to magnetic reconnection.

  17. Mass varying neutrinos, quintessence, and the accelerating expansion of the Universe

    SciTech Connect (OSTI)

    Chitov, Gennady Y.; August, Tyler [Department of Physics, Laurentian University, Ramsey Lake Road, Sudbury, ON, P3E 2C6 (Canada); Natarajan, Aravind [McWilliams Center for Cosmology and Department of Physics, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, Pennsylvania 15213 (United States); Kahniashvili, Tina [McWilliams Center for Cosmology and Department of Physics, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, Pennsylvania 15213 (United States); Department of Physics, Laurentian University, Ramsey Lake Road, Sudbury, ON, P3E 2C6 (Canada); National Abastumani Astrophysical Observatory, Ilia Chavchavadze State University, 2A Kazbegi Ave, Tbilisi, GE-0160 (Georgia)

    2011-02-15

    We analyze the mass varying neutrino scenario. We consider a minimal model of massless Dirac fermions coupled to a scalar field, mainly in the framework of finite-temperature quantum field theory. We demonstrate that the mass equation we find has nontrivial solutions only for special classes of potentials, and only within certain temperature intervals. We give most of our results for the Ratra-Peebles dark energy (DE) potential. The thermal (temporal) evolution of the model is analyzed. Following the time arrow, the stable, metastable, and unstable phases are predicted. The model predicts that the present Universe is below its critical temperature and accelerates. At the critical point, the Universe undergoes a first-order phase transition from the (meta)stable oscillatory regime to the unstable rolling regime of the DE field. This conclusion agrees with the original idea of quintessence as a force making the Universe roll towards its true vacuum with a zero {Lambda} term. The present mass varying neutrino scenario is free from the coincidence problem, since both the DE density and the neutrino mass are determined by the scale M of the potential. Choosing M{approx}10{sup -3} eV to match the present DE density, we can obtain the present neutrino mass in the range m{approx}10{sup -2}-1 eV and consistent estimates for other parameters of the Universe.

  18. Chemical Characterization of Crude Petroleum Using Nanospray Desorption Electrospray Ionization Coupled with High-Resolution Mass Spectrometry

    SciTech Connect (OSTI)

    Eckert, Peter A.; Roach, Patrick J.; Laskin, Alexander; Laskin, Julia

    2012-02-07

    Nanospray desorption electrospray ionization (nano-DESI) combined with high-resolution mass spectrometry was used for the first time for the analysis of liquid petroleum crude oil samples. The analysis was performed in both positive and negative ionization modes using three solvents one of which (acetonitrile/toluene mixture) is commonly used in petroleomics studies while two other polar solvents (acetonitrile/water and methanol/water mixtures) are generally not compatible with petroleum characterization using mass spectrometry. The results demonstrate that nano-DESI analysis efficiently ionizes petroleum constituents soluble in a particular solvent. When acetonitrile/toluene is used as a solvent, nano-DESI generates electrospray-like spectra. In contrast, strikingly different spectra were obtained using acetonitrile/water and methanol/water. Comparison with the literature data indicates that these solvents selectively extract water-soluble constituents of the crude oil. Water-soluble compounds are predominantly observed as sodium adducts in nano-DESI spectra indicating that addition of sodium to the solvent may be a viable approach for efficient ionization of water-soluble crude oil constituents. Nano-DESI enables rapid screening of different classes of compounds in crude oil samples using solvents that are rarely used for petroleum characterization.

  19. Calibration of laser ablation inductively coupled plasma mass spectrometry using dried solution aerosols for the quantitative analysis of solid samples

    SciTech Connect (OSTI)

    Leach, J.

    1999-02-12

    Inductively coupled plasma mass spectrometry (ICP-MS) has become the method of choice for elemental and isotopic analysis. Several factors contribute to its success. Modern instruments are capable of routine analysis at part per trillion levels with relative detection limits in part per quadrillion levels. Sensitivities in these instruments can be as high as 200 million counts per second per part per million with linear dynamic ranges up to eight orders of magnitude. With standards for only a few elements, rapid semiquantitative analysis of over 70 elements in an individual sample can be performed. Less than 20 years after its inception ICP-MS has shown to be applicable to several areas of science. These include geochemistry, the nuclear industry, environmental chemistry, clinical chemistry, the semiconductor industry, and forensic chemistry. In this introduction, the general attributes of ICP-MS will be discussed in terms of instrumentation and sample introduction. The advantages and disadvantages of current systems are presented. A detailed description of one method of sample introduction, laser ablation, is given. The paper also gives conclusions and suggestions for future work. Chapter 2, Quantitative analysis of solids by laser ablation inductively coupled plasma mass spectrometry using dried solution aerosols for calibration, has been removed for separate processing.

  20. Biological Mass Spectrometry and Shotgun Proteomics of Microbial Systems: Methods for studying microbial physiology from isolates to environmental communities

    SciTech Connect (OSTI)

    Dill, Brian; Young, Jacque C; Carey, Patricia A; Verberkmoes, Nathan C

    2010-01-01

    Microbial ecology is currently experiencing a renaissance spurred by the rapid development of molecular techniques and omics technologies in particular. As never before, these tools have allowed researchers in the field to produce a massive amount of information through in situ measurements and analysis of natural microbial communities, both vital approaches to the goal of unraveling the interactions of microbes with their environment and with one another. While genomics can provide information regarding the genetic potential of microbes, proteomics characterizes the primary end-stage product, proteins, thus conveying functional information concerning microbial activity. Advances in mass spectrometry instrumentation and methodologies, along with bioinformatic approaches, have brought this analytic chemistry technique to relevance in the biological realm due to its powerful applications in proteomics. Mass spectrometry-enabled proteomics, including bottom-up and top-down approaches, is capable of supplying a wealth of biologically-relevant information, from simple protein cataloging of the proteome of a microbial community to identifying post-translational modifications of individual proteins.

  1. Characterization of direct current He-N{sub 2} mixture plasma using optical emission spectroscopy and mass spectrometry

    SciTech Connect (OSTI)

    Flores, O.; Castillo, F.; Martinez, H.; Villa, M.; Reyes, P. G.; Villalobos, S.; Facultad de Ingeniería, Universidad Nacional Autónoma de México, México D.F.

    2014-05-15

    This study analyses the glow discharge of He and N{sub 2} mixture at the pressure of 2.0?Torr, power of 10?W, and flow rate of 16.5?l/min, by using optical emission spectroscopy and mass spectrometry. The emission bands were measured in the wavelength range of 200–1100?nm. The principal species observed were N{sub 2}{sup +} (B{sup 2}?{sup +}{sub u}?X{sup 2}?{sup +}{sub g}), N{sub 2} (C{sup 3}?{sub u}?B{sup 3}?{sub g}), and He, which are in good agreement with the results of mass spectrometry. Besides, the electron temperature and ion density were determined by using a double Langmuir probe. Results indicate that the electron temperature is in the range of 1.55–2.93?eV, and the electron concentration is of the order of 10{sup 10}?cm{sup ?3}. The experimental results of electron temperature and ion density for pure N{sub 2} and pure He are in good agreement with the values reported in the literature.

  2. Validating mass spectrometry measurements of nuclear materials via a non-contact volume analysis method of ion sputter craters

    SciTech Connect (OSTI)

    Willingham, David G.; Naes, Benjamin E.; Fahey, Albert J.

    2015-01-01

    A combination of secondary ion mass spectrometry, optical profilometry and a statistically-driven algorithm was used to develop a non-contact volume analysis method to validate the useful yields of nuclear materials. The volume analysis methodology was applied to ion sputter craters created in silicon and uranium substrates sputtered by 18.5 keV O- and 6.0 keV Ar+ ions. Sputter yield measurements were determined from the volume calculations and were shown to be comparable to Monte Carlo calculations and previously reported experimental observations. Additionally, the volume calculations were used to determine the useful yields of Si+, SiO+ and SiO2+ ions from the silicon substrate and U+, UO+ and UO2+ ions from the uranium substrate under 18.5 keV O- and 6.0 keV Ar+ ion bombardment. This work represents the first steps toward validating the interlaboratory and cross-platform performance of mass spectrometry for the analysis of nuclear materials.

  3. Comprehensive quantification of triacylglycerols in soybean seeds by electrospray ionization mass spectrometry with multiple neutral loss scans

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Li, Maoyin; Butka, Emily; Wang, Xuemin

    2014-10-10

    Soybean seeds are an important source of vegetable oil and biomaterials. The content of individual triacylglycerol species (TAG) in soybean seeds is difficult to quantify in an accurate and rapid way. The present study establishes an approach to quantify TAG species in soybean seeds utilizing an electrospray ionization tandem mass spectrometry with multiple neutral loss scans. Ten neutral loss scans were performed to detect the fatty acyl chains of TAG, including palmitic (P, 1650), linolenic (Ln, 1853), linoleic (L, 1852), oleic (O, 1851), stearic (S, 1850), eicosadienoic (2052), gadoleic (2051), arachidic (2050), erucic (2251), and behenic (2250). The abundance ofmore » ten fatty acyl chains at 46 TAG masses (mass-to-charge ratio, m/z) were determined after isotopic deconvolution and correction by adjustment factors at each TAG mass. The direct sample infusion and multiple internal standards correction allowed a rapid and accurate quantification of TAG species. Ninety-three TAG species were resolved and their levels were determined.The most abundant TAG species were LLL, OLL, LLLn, PLL, OLLn, OOL, POL, and SLL. Many new species were detected and quantified. As a result, this shotgun lipidomics approach should facilitate the study of TAG metabolism and genetic breeding of soybean seeds for desirable TAG content and composition.« less

  4. Comprehensive quantification of triacylglycerols in soybean seeds by electrospray ionization mass spectrometry with multiple neutral loss scans

    SciTech Connect (OSTI)

    Li, Maoyin; Butka, Emily; Wang, Xuemin

    2014-10-10

    Soybean seeds are an important source of vegetable oil and biomaterials. The content of individual triacylglycerol species (TAG) in soybean seeds is difficult to quantify in an accurate and rapid way. The present study establishes an approach to quantify TAG species in soybean seeds utilizing an electrospray ionization tandem mass spectrometry with multiple neutral loss scans. Ten neutral loss scans were performed to detect the fatty acyl chains of TAG, including palmitic (P, 1650), linolenic (Ln, 1853), linoleic (L, 1852), oleic (O, 1851), stearic (S, 1850), eicosadienoic (2052), gadoleic (2051), arachidic (2050), erucic (2251), and behenic (2250). The abundance of ten fatty acyl chains at 46 TAG masses (mass-to-charge ratio, m/z) were determined after isotopic deconvolution and correction by adjustment factors at each TAG mass. The direct sample infusion and multiple internal standards correction allowed a rapid and accurate quantification of TAG species. Ninety-three TAG species were resolved and their levels were determined.The most abundant TAG species were LLL, OLL, LLLn, PLL, OLLn, OOL, POL, and SLL. Many new species were detected and quantified. As a result, this shotgun lipidomics approach should facilitate the study of TAG metabolism and genetic breeding of soybean seeds for desirable TAG content and composition.

  5. THE APPLICATION OF SINGLE PARTICLE AEROSOL MASS SPECTROMETRY FOR THE DETECTION AND IDENTIFICATION OF HIGH EXPLOSIVES AND CHEMICAL WARFARE AGENTS

    SciTech Connect (OSTI)

    Martin, A

    2006-10-23

    Single Particle Aerosol Mass Spectrometry (SPAMS) was evaluated as a real-time detection technique for single particles of high explosives. Dual-polarity time-of-flight mass spectra were obtained for samples of 2,4,6-trinitrotoluene (TNT), 1,3,5-trinitro-1,3,5-triazinane (RDX), and pentaerythritol tetranitrate (PETN); peaks indicative of each compound were identified. Composite explosives, Comp B, Semtex 1A, and Semtex 1H were also analyzed, and peaks due to the explosive components of each sample were present in each spectrum. Mass spectral variability with laser fluence is discussed. The ability of the SPAMS system to identify explosive components in a single complex explosive particle ({approx}1 pg) without the need for consumables is demonstrated. SPAMS was also applied to the detection of Chemical Warfare Agent (CWA) simulants in the liquid and vapor phases. Liquid simulants for sarin, cyclosarin, tabun, and VX were analyzed; peaks indicative of each simulant were identified. Vapor phase CWA simulants were adsorbed onto alumina, silica, Zeolite, activated carbon, and metal powders which were directly analyzed using SPAMS. The use of metal powders as adsorbent materials was especially useful in the analysis of triethyl phosphate (TEP), a VX stimulant, which was undetectable using SPAMS in the liquid phase. The capability of SPAMS to detect high explosives and CWA simulants using one set of operational conditions is established.

  6. Improving the Sensitivity of Mass Spectrometry by Using a New Sheath Flow Electrospray Emitter Array at Subambient Pressures

    SciTech Connect (OSTI)

    Cox, Jonathan T.; Marginean, Ioan; Kelly, Ryan T.; Smith, Richard D.; Tang, Keqi

    2014-12-01

    Arrays of chemically etched emitters with individualized sheath gas capillaries have been developed to enhance electrospray ionization (ESI) at subambient pressures. By including an emitter array in a subambient pressure ionization with nanoelectrospray (SPIN) source, ionization and transmission efficiency can be maximized allowing for increased sensitivity in mass spectrometric analyses. The SPIN source eliminates the major ion losses at conventional ESI-mass spectrometry (MS) interface by placing the emitter in the first vacuum region of the instrument. To facilitate stable electrospray currents in such conditions we have developed an improved emitter array with individualized sheath gas around each emitter. The utility of the new emitter arrays for generating stable multi-electrosprays at subambient pressures was probed by coupling the emitter array/SPIN source with a time of flight (TOF) mass spectrometer. The instrument sensitivity was compared between single emitter/SPIN-MS and multi-emitter/SPIN-MS configurations using an equimolar solution of 9 peptides. An increase in sensitivity correlative to the number of emitters in the array was observed.

  7. Parallel Configuration For Fast Superconducting Strip Line Detectors With Very Large Area In Time Of Flight Mass Spectrometry

    SciTech Connect (OSTI)

    Casaburi, A.; Zen, N.; Suzuki, K.; Ohkubo, M.; Ejrnaes, M.; Cristiano, R.; Pagano, S.

    2009-12-16

    We realized a very fast and large Superconducting Strip Line Detector based on a parallel configuration of nanowires. The detector with size 200x200 {mu}m{sup 2} recorded a sub-nanosecond pulse width of 700 ps in FWHM (400 ps rise time and 530 ps relaxation time) for lysozyme monomers/multimers molecules accelerated at 175 keV in a Time of Flight Mass Spectrometer. This record is the best in the class of superconducting detectors and comparable with the fastest NbN superconducting single photon detector of 10x10 {mu}m{sup 2}. We succeeded in acquiring mass spectra as the first step for a scale-up to {approx}mm pixel size for high throughput MS analysis, while keeping a fast response.

  8. Laser vaporization/ionization interface for coupling microscale separation techniques with mass spectrometry

    DOE Patents [OSTI]

    Yeung, E.S.; Chang, Y.C.

    1999-06-29

    The present invention provides a laser-induced vaporization and ionization interface for directly coupling microscale separation processes to a mass spectrometer. Vaporization and ionization of the separated analytes are facilitated by the addition of a light-absorbing component to the separation buffer or solvent. 8 figs.

  9. Laser vaporization/ionization interface for coupling microscale separation techniques with mass spectrometry

    DOE Patents [OSTI]

    Yeung, Edward S. (Ames, IA); Chang, Yu-chen (Taichung Hsien, TW)

    1999-06-29

    The present invention provides a laser-induced vaporization and ionization interface for directly coupling microscale separation processes to a mass spectrometer. Vaporization and ionization of the separated analytes are facilitated by the addition of a light-absorbing component to the separation buffer or solvent.

  10. Reduction of plyatomic ion interferences in indictively coupled plasma mass spectrometry with cryogenic desolvation

    SciTech Connect (OSTI)

    Alves, L.C.

    1993-09-01

    A desolvation scheme for introducing aqueous and organic samples into an argon inductively coupled plasma is described; the aerosol generated by nebulizer is heated (+140 C) and cooled ({minus}80 C) repeatedly, and the dried aerosol is then injected into the mass spectrometer. Polyatomic ions are greatly suppressed. This scheme was validated with analysis of seawater and urine reference samples. Finally, the removal of organic solvents by cryogenic desolvation was studied.

  11. Real-time monitoring of volatile organic compounds using chemical ionization mass spectrometry

    DOE Patents [OSTI]

    Mowry, Curtis Dale; Thornberg, Steven Michael

    1999-01-01

    A system for on-line quantitative monitoring of volatile organic compounds (VOCs) includes pressure reduction means for carrying a gaseous sample from a first location to a measuring input location maintained at a low pressure, the system utilizing active feedback to keep both the vapor flow and pressure to a chemical ionization mode mass spectrometer constant. A multiple input manifold for VOC and gas distribution permits a combination of calibration gases or samples to be applied to the spectrometer.

  12. Mass spectrometry-based methods for detection and differentiation of botulinum neurotoxins

    DOE Patents [OSTI]

    Schmidt, Jurgen G. (Los Alamos, NM); Boyer, Anne E. (Atlanta, GA); Kalb, Suzanne R. (Atlanta, GA); Moura, Hercules (Tucker, GA); Barr, John R. (Suwannee, GA); Woolfitt, Adrian R. (Atlanta, GA)

    2009-11-03

    The present invention is directed to a method for detecting the presence of clostridial neurotoxins in a sample by mixing a sample with a peptide that can serve as a substrate for proteolytic activity of a clostridial neurotoxin; and measuring for proteolytic activity of a clostridial neurotoxin by a mass spectroscopy technique. In one embodiment, the peptide can have an affinity tag attached at two or more sites.

  13. Molecular Characterization of Organic Aerosol Using Nanospray Desorption/Electrospray Ionization Mass Spectrometry: CalNex 2010 field study

    SciTech Connect (OSTI)

    O'Brien, Rachel E.; Laskin, Alexander; Laskin, Julia; Liu, Shang; Weber, Robin; Russell, Lynn; Goldstein, Allen H.

    2013-04-01

    Aerosol samples from the CalNex 2010 field study were analyzed using high resolution mass spectrometry (HR-MS) coupled to a nanospray-desorption/electrospray ionization (nano-DESI) source. The samples were collected in Bakersfield, CA on June 22-23, 2010. The chemical formulas of over 1300 unique molecular species were detected in the mass range of 50-800 m/z. Our analysis focused on identification of two main groups: compounds containing only carbon, hydrogen, and oxygen (CHO only), and nitrogen-containing organic compounds (NOC). The NOC accounted for 35% (by number) of the compounds observed in the afternoon, and for 59% in the early morning samples. By comparing plausible reactant-product pairs, we propose that over 50% of the NOC in each sample could have been formed through reactions transforming carbonyls into imines. The CHO only compounds were dominant in the afternoon suggesting a photochemical source. The average O:C ratios of all observed compounds were fairly consistent throughout the day, ranging from 0.34 in the early morning to 0.37 at night. We conclude that both photooxidation and ammonia chemistry play important roles in forming the compounds observed in this mixed urban-rural environment.

  14. Polysialylated N-Glycans Identified in Human Serum Through Combined Developments in Sample Preparation, Separations and Electrospray ionization-mass spectrometry

    SciTech Connect (OSTI)

    Kronewitter, Scott R.; Marginean, Ioan; Cox, Jonathan T.; Zhao, Rui; Hagler, Clay D.; Shukla, Anil K.; Carlson, Timothy S.; Adkins, Joshua N.; Camp, David G.; Moore, Ronald J.; Rodland, Karin D.; Smith, Richard D.

    2014-09-02

    The N-glycan diversity of human serum glycoproteins, i.e. the human blood serum N-glycome, is complex due to the range of glycan structures potentially synthesizable by human glycosylation enzymes. The reported glycome, however, is limited by methods of sample preparation, available analytical platforms, e.g., based upon electrospray ionization-mass spectrometry (ESI-MS), and software tools for data analysis. In this report, several improvements have been implemented in sample preparation and analysis to extend ESI-MS glycan characterization and to provide an improved view of glycan diversity. Sample preparation improvements include acidified, microwave-accelerated, PNGase F N-glycan release, and sodium borohydride reduction were optimized to improve quantitative yields and conserve the number of glycoforms detected. Two-stage desalting (during solid phase extraction and on the analytical column) increased the sensitivity by reducing analyte signal division between multiple reducing-end-forms or cation adducts. On-line separations were improved by using extended length graphitized carbon columns and adding TFA as an acid modifier to a formic acid/reversed phase gradient which provides additional resolving power and significantly improved desorption of both large and heavily sialylated glycans. To improve MS sensitivity and provide gentler ionization conditions at the source-MS interface, subambient pressure ionization with nanoelectrospray (SPIN) has been utilized. When method improvements are combined together with the Glycomics Quintavariate Informed Quantification (GlyQ-IQ) recently described1 these technologies demonstrate the ability to significantly extend glycan detection sensitivity and provide expanded glycan coverage. We demonstrate application of these advances in the context of the human serum glycome, and for which our initial observations include detection of a new class of heavily sialylated N-glycans, including polysialylated N-glycans.

  15. Characterization of Plasma Membrane Proteins from Ovarian Cancer Cells Using Mass Spectrometry

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Springer, David L.; Auberry, Deanna L.; Ahram, Mamoun; Adkins, Joshua N.; Feldhaus, Jane M.; Wahl, Jon H.; Wunschel, David S.; Rodland, Karin D.

    2004-01-01

    To determine how the repertoire of plasma membrane proteins change with disease state, specifically related to cancer, several methods for preparation of plasma membrane proteins were evaluated. Cultured cells derived from stage IV ovarian tumors were grown to 90% confluence and harvested in buffer containing CHAPS detergent. This preparation was centrifuged at low speed to remove insoluble cellular debris resulting in a crude homogenate. Glycosylated proteins in the crude homogenate were selectively enriched using lectin affinity chromatography. The crude homogenate and the lectin purified sample were prepared for mass spectrometric evaluation. The general procedure for protein identification began with trypsinmore » digestion of protein fractions followed by separation by reversed phase liquid chromatography that was coupled directly to a conventional tandem mass spectrometer (i.e. LCQ ion trap). Mass and fragmentation data for the peptides were searched against a human proteome data base using the informatics program SEQUEST. Using this procedure 398 proteins were identified with high confidence, including receptors, membrane-associated ligands, proteases, phosphatases, as well as structural and adhesion proteins. Results indicate that lectin chromatography provides a select subset of proteins and that the number and quality of the identifications improve as does the confidence of the protein identifications for this subset. These results represent the first step in development of methods to separate and successfully identify plasma membrane proteins from advanced ovarian cancer cells. Further characterization of plasma membrane proteins will contribute to our understanding of the mechanisms underlying progression of this deadly disease and may lead to new targeted interventions as well as new biomarkers for diagnosis.« less

  16. Characterization of Plasma Membrane Proteins from Ovarian Cancer Cells Using Mass Spectrometry

    SciTech Connect (OSTI)

    Springer, David L.; Auberry, Deanna L.; Ahram, Mamoun; Adkins, Joshua N.; Feldhaus, Jane M.; Wahl, Jon H.; Wunsch, David M.; Rodland, Karin D.

    2003-01-01

    To determine how the repertoire of plasma membrane proteins change with disease state, specifically related to cancer, several methods for preparation of plasma membrane proteins were evaluated. Cultured cells derived from stage IV ovarian tumors were grown to 90% confluence and harvested in buffer containing CHAPS detergent. This preparation was centrifuged at low speed to remove insoluble cellular debris resulting in a crude homogenate. Glycosylated proteins in the crude homogenate were selectively enriched using lectin affinity chromatography. The crude homogenate and the lectin purified sample were prepared for mass spectrometric evaluation. The general procedure for protein identification began with trypsin digestion of protein fractions followed by separation by reversed phase liquid chromatography that was coupled directly to a conventional tandem mass spectrometer (i.e. LCQ ion trap). Mass and fragmentation data for the peptides were searched against a human proteome data base using the informatics program SEQUEST. Using this procedure 398 proteins were identified with high confidence, including receptors, membrane-associated ligands, proteases, phosphatases, as well as structural and adhesion proteins. Results indicate that lectin chromatography provides a select subset of proteins and that the number and quality of the identifications improve as does the confidence of the protein identifications for this subset. These results represent the first step in development of methods to separate and successfully identify plasma membrane proteins from advanced ovarian cancer cells. Further characterization of plasma membrane proteins will contribute to our understanding of the mechanisms underlying progression of this deadly disease and may lead to new targeted interventions as well as new biomarkers for diagnosis.

  17. Kinetics of laser-pulse vaporization of uranium carbide by mass spectrometry. [LMFBR

    SciTech Connect (OSTI)

    Tehranian, F.

    1983-06-01

    The kinetics of uranium carbide vaporization in the temperature range 3000 K to 5200 K was studied using a Nd-glass laser with peak power densities from 1.6 x 10/sup 5/ to 4.0 x 10/sup 5/ watts/cm/sup 2/. The vapor species U, UC/sub 2/, C/sub 1/ and C/sub 3/ were detected and analyzed by a quadrupole mass spectrometer. From the mass spectrometer signals number densities of the various species in the ionizer were obtained as functions of time. The surface of the irradiated uranium carbide was examined by scanning electron microscope and the depth profile of the crater was obtained. In order to aid analysis of the data, the heat conduction and species diffusion equations for the solid (or liquid) were solved numerically by a computer code to obtain the temperature and composition transients during laser heating. A sensitivity analysis was used to study the effect of uncertainties in the input parameters on the computed surface temperatures.

  18. An Adaptable Multiple Power Source for Mass Spectrometry and other Scientific Instruments

    SciTech Connect (OSTI)

    Lin, Tzu-Yung; Anderson, Gordon A.; Norheim, Randolph V.; Prost, Spencer A.; Lamarche, Brian L.; Leach, Franklin E.; Auberry, Kenneth J.; Smith, Richard D.; Koppenaal, David W.; Robinson, Errol W.; Pasa-Tolic, Ljiljana

    2015-09-18

    Power supplies are commonly used in the operation of many types of scientific equipment, including mass spectrometers and ancillary instrumentation. A generic modern mass spectrometer comprises an ionization source, such as electrospray ionization (ESI), ion transfer devices such as ion funnels and multipole ion guides, and ion signal detection apparatus. Very often such platforms include, or are interfaced with ancillary elements in order to manipulate samples before or after ionization. In order to operate such scientific instruments, numerous direct current (DC) channels and radio frequency (RF) signals are required, along with other controls such as temperature regulation. In particular, DC voltages in the range of ±400 V, along with MHz range RF signals with peak-to-peak amplitudes in the hundreds of volts range are commonly used to transfer ionized samples under vacuum. Additionally, an ESI source requires a high voltage (HV) DC source capable of producing several thousand volts and heaters capable of generating temperatures up to 300°C. All of these signals must be properly synchronized and managed in order to carry out ion trapping, accumulation and detection.

  19. Extending the Capabilities of Single Particle Mass Spectrometry: II. Measurements of Aerosol Particle Density without DMA

    SciTech Connect (OSTI)

    Vaden, Timothy D.; Imre, D.; Beranek, Josef; Zelenyuk, Alla

    2011-01-04

    Particle density is an important and useful property that is difficult to measure because it usually 5 requires separate instruments to measure two particle attributes. As density measurements are 6 often performed on size-classified particles, they are hampered by low particle numbers, and 7 hence poor temporal resolution. We present here a new method for measuring particle densities 8 using our single particle mass spectrometer, SPLAT. This method takes advantage of the fact 9 that the detection efficiency in our single particle mass spectrometer drops off very rapidly as the 10 particle size decreases below ~125 nm creating a distinct sharp feature on the small particle side 11 of the vacuum aerodynamic size distribution. Thus, the two quantities needed to determine 12 particle density, the particle diameter and vacuum aerodynamic diameter, are known. We first 13 test this method on particles of known composition and find that the densities it yields are 14 sufficiently accurate. We then apply the method to obtain the densities of particles that were 15 characterized during an airborne field campaign. In addition, we show that the distinctive 16 features of the vacuum aerodynamic size distribution can be used to characterize the instrument 17 detection efficiency as a function of particle size. In general, the method presented here reduces 18 complexity and yields information with high temporal resolution while the instrument is 19 collecting routine data on particle size and composition.

  20. Laser-ablation sampling for inductively coupled plasma distance-of-flight mass spectrometry

    SciTech Connect (OSTI)

    Gundlach-Graham, Alexander W.; Dennis, Elise; Ray, Steven J.; Enke, Christie G.; Barinaga, Charles J.; Koppenaal, David W.; Hieftje, Gary M.

    2015-01-01

    An inductively coupled plasma distance-of-flight mass spectrometer (ICP-DOFMS) has been coupled with laser-ablation (LA) sample introduction for the elemental analysis of solids. ICP-DOFMS is well suited for the analysis of laser-generated aerosols because it offers both high-speed mass analysis and simultaneous multi-elemental detection. Here, we evaluate the analytical performance of the LA-ICP-DOFMS instrument, equipped with a microchannel plate-based imaging detector, for the measurement of steady-state LA signals, as well as transient signals produced from single LA events. Steady-state detection limits are 1 mg g1, and absolute single-pulse LA detection limits are 200 fg for uranium; the system is shown capable of performing time-resolved single-pulse LA analysis. By leveraging the benefits of simultaneous multi-elemental detection, we also attain a good shot-to-shot reproducibility of 6% relative standard deviation (RSD) and isotope-ratio precision of 0.3% RSD with a 10 s integration time.

  1. Final LDRD report : development of sample preparation methods for ChIPMA-based imaging mass spectrometry of tissue samples.

    SciTech Connect (OSTI)

    Maharrey, Sean P.; Highley, Aaron M.; Behrens, Richard, Jr.; Wiese-Smith, Deneille

    2007-12-01

    The objective of this short-term LDRD project was to acquire the tools needed to use our chemical imaging precision mass analyzer (ChIPMA) instrument to analyze tissue samples. This effort was an outgrowth of discussions with oncologists on the need to find the cellular origin of signals in mass spectra of serum samples, which provide biomarkers for ovarian cancer. The ultimate goal would be to collect chemical images of biopsy samples allowing the chemical images of diseased and nondiseased sections of a sample to be compared. The equipment needed to prepare tissue samples have been acquired and built. This equipment includes an cyro-ultramicrotome for preparing thin sections of samples and a coating unit. The coating unit uses an electrospray system to deposit small droplets of a UV-photo absorbing compound on the surface of the tissue samples. Both units are operational. The tissue sample must be coated with the organic compound to enable matrix assisted laser desorption/ionization (MALDI) and matrix enhanced secondary ion mass spectrometry (ME-SIMS) measurements with the ChIPMA instrument Initial plans to test the sample preparation using human tissue samples required development of administrative procedures beyond the scope of this LDRD. Hence, it was decided to make two types of measurements: (1) Testing the spatial resolution of ME-SIMS by preparing a substrate coated with a mixture of an organic matrix and a bio standard and etching a defined pattern in the coating using a liquid metal ion beam, and (2) preparing and imaging C. elegans worms. Difficulties arose in sectioning the C. elegans for analysis and funds and time to overcome these difficulties were not available in this project. The facilities are now available for preparing biological samples for analysis with the ChIPMA instrument. Some further investment of time and resources in sample preparation should make this a useful tool for chemical imaging applications.

  2. Acceleration switch

    DOE Patents [OSTI]

    Abbin, Jr., Joseph P. (Albuquerque, NM); Devaney, Howard F. (Cedar Crest, NM); Hake, Lewis W. (Albuquerque, NM)

    1982-08-17

    The disclosure relates to an improved integrating acceleration switch of the type having a mass suspended within a fluid filled chamber, with the motion of the mass initially opposed by a spring and subsequently not so opposed.

  3. Elemental ratio measurements of organic compounds using aerosol mass spectrometry: characterization, improved calibration, and implications

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Canagaratna, M. R.; Jimenez, J. L.; Kroll, J. H.; Chen, Q.; Kessler, S. H.; Massoli, P.; Hildebrandt Ruiz, L.; Fortner, E.; Williams, L. R.; Wilson, K. R.; et al

    2015-01-12

    Elemental compositions of organic aerosol (OA) particles provide useful constraints on OA sources, chemical evolution, and effects. The Aerodyne high-resolution time-of-flight aerosol mass spectrometer (HR-ToF-AMS) is widely used to measure OA elemental composition. This study evaluates AMS measurements of atomic oxygen-to-carbon (O : C), hydrogen-to-carbon (H : C), and organic mass-to-organic carbon (OM : OC) ratios, and of carbon oxidation state (OS C) for a vastly expanded laboratory data set of multifunctional oxidized OA standards. For the expanded standard data set, the method introduced by Aiken et al. (2008), which uses experimentally measured ion intensities at all ions to determinemore » elemental ratios (referred to here as "Aiken-Explicit"), reproduces known O : C and H : C ratio values within 20% (average absolute value of relative errors) and 12%, respectively. The more commonly used method, which uses empirically estimated H2O+ and CO+ ion intensities to avoid gas phase air interferences at these ions (referred to here as "Aiken-Ambient"), reproduces O : C and H : C of multifunctional oxidized species within 28 and 14% of known values. The values from the latter method are systematically biased low, however, with larger biases observed for alcohols and simple diacids. A detailed examination of the H2O+, CO+, and CO2+ fragments in the high-resolution mass spectra of the standard compounds indicates that the Aiken-Ambient method underestimates the CO+ and especially H2O+ produced from many oxidized species. Combined AMS–vacuum ultraviolet (VUV) ionization measurements indicate that these ions are produced by dehydration and decarboxylation on the AMS vaporizer (usually operated at 600 °C). Thermal decomposition is observed to be efficient at vaporizer temperatures down to 200 °C. These results are used together to develop an "Improved-Ambient" elemental analysis method for AMS spectra measured in air. The Improved-Ambient method uses specific ion fragments as markers to correct for molecular functionality-dependent systematic biases and reproduces known O : C (H : C) ratios of individual oxidized standards within 28% (13%) of the known molecular values. The error in Improved-Ambient O : C (H : C) values is smaller for theoretical standard mixtures of the oxidized organic standards, which are more representative of the complex mix of species present in ambient OA. For ambient OA, the Improved-Ambient method produces O : C (H : C) values that are 27% (11%) larger than previously published Aiken-Ambient values; a corresponding increase of 9% is observed for OM : OC values. These results imply that ambient OA has a higher relative oxygen content than previously estimated. The OS C values calculated for ambient OA by the two methods agree well, however (average relative difference of 0.06 OS C units). This indicates that OS C is a more robust metric of oxidation than O : C, likely since OS C is not affected by hydration or dehydration, either in the atmosphere or during analysis.« less

  4. Elemental ratio measurements of organic compounds using aerosol mass spectrometry: characterization, improved calibration, and implications

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Canagaratna, M. R.; Jimenez, J. L.; Kroll, J. H.; Chen, Q.; Kessler, S. H.; Massoli, P.; Hildebrandt Ruiz, L.; Fortner, E.; Williams, L. R.; Wilson, K. R.; et al

    2014-07-31

    Elemental compositions of organic aerosol (OA) particles provide useful constraints on OA sources, chemical evolution, and effects. The Aerodyne high-resolution time-of-flight aerosol mass spectrometer (HR-ToF-AMS) is widely used to measure OA elemental composition. This study evaluates AMS measurements of atomic oxygen-to-carbon (O : C), hydrogen-to-carbon (H : C), organic mass-to-organic carbon (OM : OC), and carbon oxidation state (OSC) for a vastly expanded laboratory dataset of multifunctional oxidized OA standards. For the expanded standard dataset, the "Aiken-Explicit" method (Aiken et al., 2008), which uses experimentally measured ion intensities at all ions to determine elemental ratios, reproduces known molecular O :more » C and H : C ratio values within 20% (average absolute value of relative errors) and 12% respectively. The more commonly used "Aiken-Ambient" method, which uses empirically estimated H2O+ and CO+ ion intensities to avoid gas phase air interferences at these ions, reproduces O : C and H : C of multifunctional oxidized species within 28% and 14% of known values. These values are systematically biased low, however, with larger biases observed for alcohols and simple diacids. A detailed examination of the H2O+, CO+, and CO2+ fragments in the high-resolution mass spectra of the standard compounds indicates that the Aiken-Ambient method underestimates the CO+ and H2O+ produced from many oxidized species. Combined AMS-vacuum ultraviolet (VUV) ionization measurements indicate that these ions are produced by dehydration and decarboxylation on the AMS vaporizer (usually operated at 600 °C). Thermal decomposition is observed to be efficient at vaporizer temperatures down to 200 °C. These results are used together to develop an "Improved-Ambient" elemental analysis method for AMS spectra measured in air. The Improved-Ambient method reduces the systematic biases and reproduces O : C (H : C) ratios of individual oxidized standards within 28% (13%) of the known molecular values. The error in Improved-Ambient O : C and H : C values is smaller (12% and 4% respectively) for synthetic mixtures of the oxidized organic standards, which are more representative of the complex mix of species present in ambient OA. For ambient OA, the Improved-Ambient method produces O : C (H : C) values that are 27% (11%) larger than previously published Aiken-Ambient values; a corresponding increase of 9% is observed for OM : OC values. These results imply that ambient OA has a higher relative oxygen content than previously estimated. The OSC values calculated for ambient OA by the two methods agree well, however (average relative difference of 0.06 OSC units). This indicates that OSC is a more robust metric of oxidation than O : C, likely since OSC is not affected by hydration or dehydration, either in the atmosphere or during analysis.« less

  5. Elemental ratio measurements of organic compounds using aerosol mass spectrometry: Characterization, improved calibration, and implications

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Canagaratna, M. R.; Jimenez, J. L.; Kroll, J. H.; Chen, Q.; Kessler, S. H.; Massoli, P.; Ruiz, L. Hildebrandt; Fortner, E.; Williams, L. R.; Wilson, K. R.; et al

    2015-01-12

    Elemental compositions of organic aerosol (OA) particles provide useful constraints on OA sources, chemical evolution, and effects. The Aerodyne high-resolution time-of-flight aerosol mass spectrometer (HR-ToF-AMS) is widely used to measure OA elemental composition. This study evaluates AMS measurements of atomic oxygen-to-carbon (O : C), hydrogen-to-carbon (H : C), and organic mass-to-organic carbon (OM : OC) ratios, and of carbon oxidation state (OS C) for a vastly expanded laboratory data set of multifunctional oxidized OA standards. For the expanded standard data set, the method introduced by Aiken et al. (2008), which uses experimentally measured ionmore »intensities at all ions to determine elemental ratios (referred to here as "Aiken-Explicit"), reproduces known O : C and H : C ratio values within 20% (average absolute value of relative errors) and 12%, respectively. The more commonly used method, which uses empirically estimated H2O+ and CO+ ion intensities to avoid gas phase air interferences at these ions (referred to here as "Aiken-Ambient"), reproduces O : C and H : C of multifunctional oxidized species within 28 and 14% of known values. The values from the latter method are systematically biased low, however, with larger biases observed for alcohols and simple diacids. A detailed examination of the H2O+, CO+, and CO2+ fragments in the high-resolution mass spectra of the standard compounds indicates that the Aiken-Ambient method underestimates the CO+ and especially H2O+ produced from many oxidized species. Combined AMS–vacuum ultraviolet (VUV) ionization measurements indicate that these ions are produced by dehydration and decarboxylation on the AMS vaporizer (usually operated at 600 °C). Thermal decomposition is observed to be efficient at vaporizer temperatures down to 200 °C. These results are used together to develop an "Improved-Ambient" elemental analysis method for AMS spectra measured in air. The Improved-Ambient method uses specific ion fragments as markers to correct for molecular functionality-dependent systematic biases and reproduces known O : C (H : C) ratios of individual oxidized standards within 28% (13%) of the known molecular values. The error in Improved-Ambient O : C (H : C) values is smaller for theoretical standard mixtures of the oxidized organic standards, which are more representative of the complex mix of species present in ambient OA. For ambient OA, the Improved-Ambient method produces O : C (H : C) values that are 27% (11%) larger than previously published Aiken-Ambient values; a corresponding increase of 9% is observed for OM : OC values. These results imply that ambient OA has a higher relative oxygen content than previously estimated. The OS C values calculated for ambient OA by the two methods agree well, however (average relative difference of 0.06 OS C units). This indicates that OS C is a more robust metric of oxidation than O : C, likely since OS C is not affected by hydration or dehydration, either in the atmosphere or during analysis.« less

  6. Beyond single particle mass spectrometry: multidimensional characterisation of individual aerosol particles

    SciTech Connect (OSTI)

    Zelenyuk, Alla; Imre, D.

    2009-09-10

    The behavior of small aerosol particles depends on a number of their physical and chemical properties, many of which are strongly coupled. The size, internal composition, density, shape, morphology, hygroscopicity, index of refraction, activity as cloud condensation nuclei and ice nuclei, and other attributes of individual particles - all play a role in determining particle properties and their impacts. The traditional particle characterization approaches rely on separate parallel measurements that average over an ensemble of particles of different sizes and/or compositions and later attempt to draw correlations between them. As a result such studies overlook critical differences between particles and bulk and miss the fact that individual particles often exhibit major differences. Here we review the recently developed methods to simultaneously measure in-situ and in real time several of the attributes for individual particles using single particle mass spectrometer, SPLAT or its second generation SPLAT II. We also discuss novel approaches developed for classification, visualization and mining of large datasets produced by the multidimensional single particle characterization.

  7. Detection of Chemical/Biological Agents and Stimulants using Quadrupole Ion Trap Mass Spectrometry

    SciTech Connect (OSTI)

    Harmon, S.H.; Hart, K.J.; Vass, A.A.; Wise, M.B.; Wolf, D.A.

    1999-06-14

    Detection of Chemical/Biological Agents and Simulants A new detector for chemical and biological agents is being developed for the U. S. Army under the Chemical and Biological Mass Spectrometer Block II program. The CBMS Block II is designed to optimize detection of both chemical and biological agents through the use of direct sampling inlets [I], a multi- ported sampling valve and a turbo- based vacuum system to support chemical ionization. Unit mass resolution using air as the buffer gas [2] has been obtained using this design. Software to control the instrument and to analyze the data generated from the instrument has also been newly developed. Detection of chemical agents can be accomplished. using the CBMS Block II design via one of two inlets - a l/ I 6'' stainless steel sample line -Chemical Warfare Air (CW Air) or a ground probe with enclosed capillary currently in use by the US Army - CW Ground. The Block II design is capable of both electron ionization and chemical ionization. Ethanol is being used as the Cl reagent based on a study indicating best performance for the Biological Warfare (BW) detection task (31). Data showing good signal to noise for 500 pg of methyl salicylate injected into the CW Air inlet, 50 ng of dimethylmethylphosphonate exposed to the CW Ground probe and 5 ng of methyl stearate analyzed using the pyrolyzer inlet were presented. Biological agents are sampled using a ''bio-concentrator'' unit that is designed to concentrate particles in the low micron range. Particles are collected in the bottom of a quartz pyrolyzer tube. An automated injector is being developed to deliver approximately 2 pL of a methylating reagent, tetramethylamonium- hydroxide to 'the collected particles. Pyrolysis occurs by rapid heating to ca. 55OOC. Biological agents are then characterized by their fatty acid methyl ester profiles and by other biomarkers. A library of ETOH- Cl/ pyrolysis MS data of microorganisms used for a recently published study [3] has been expanded with additional bacteria and fungi. These spectra were acquired on a Finnigan Magnum ion trap using helium buffer gas. A new database of Cl spectra of microorganisms is planned using the CBMS Block II instrument and air as the buffer gas. Using the current database, the fatty acid composition of the organisms was compared using the percentage of the ion current attributable to fatty acids. The data presented suggest promising rules for discrimination of these organisms. Strain, growth media and vegetative state do contribute to some of the distributions observed in the data. However, the data distributions observed in the current study only reflect our experience to date and do not fully represent the variability that might be expected in practice: Acquisition of MS/ MS spectra has begun (using He and air buffer gas) of the protonated molecular ion of a variety of fatty acids and for a number of ions nominally assigned as fatty acids from microorganisms. These spectra will be used to help verify fatty acid .

  8. Molecular beam mass spectrometry with tunable vacuum ultraviolet (VUV) synchrotron radiation

    SciTech Connect (OSTI)

    Golan, Amir; Ahmed, Musahid

    2012-01-01

    Tunable soft ionization coupled to mass spectroscopy is a powerful method to investigate isolated molecules, complexes and clusters and their spectroscopy and dynamics.[1-4] Fundamental studies of photoionization processes of biomolecules provide information about electronic structure of these systems. Furthermore determinations of ionization energies and other properties of biomolecules in the gas phase are not trivial, and these experiments provide a platform to generate these data. We have developed a thermal vaporization technique coupled with supersonic molecular beams that provides a gentle way to transport these species into the gas phase. Judicious combination of source gas and temperature allows for formation of dimers and higher clusters of the DNA bases. The focus of this particular work is on the effects of non-covalent interactions, i.e., hydrogen bonding, stacking, and electrostatic interactions, on the ionization energies and proton transfer of individual biomolecules, their complexes and upon micro-hydration by water.[1, 5-9] We have performed experimental and theoretical characterization of the photoionization dynamics of gas-phase uracil and 1,3-methyluracil dimers using molecular beams coupled with synchrotron radiation at the Chemical Dynamics Beamline[10] located at the Advanced Light Source and the experimental details are visualized here. This allowed us to observe the proton transfer in 1,3-dimethyluracil dimers, a system with pi stacking geometry and with no hydrogen bonds[1]. Molecular beams provide a very convenient and efficient way to isolate the sample of interest from environmental perturbations which in return allows accurate comparison with electronic structure calculations[11, 12]. By tuning the photon energy from the synchrotron, a photoionization efficiency (PIE) curve can be plotted which informs us about the cationic electronic states. These values can then be compared to theoretical models and calculations and in turn, explain in detail the electronic structure and dynamics of the investigated species [1, 3].

  9. Investigations into the origins of polyatomic ions in inductively coupled plasma-mass spectrometry

    SciTech Connect (OSTI)

    McIntyre, Sally M.

    2010-05-16

    An inductively coupled plasma-mass spectrometer (ICP-MS) is an elemental analytical instrument capable of determining nearly all elements in the periodic table at limits of detection in the parts per quadrillion and with a linear analytical range over 8-10 orders of magnitude. Three concentric quartz tubes make up the plasma torch. Argon gas is spiraled through the outer tube and generates the plasma powered by a looped load coil operating at 27.1 or 40.6 MHz. The argon flow of the middle channel is used to keep the plasma above the innermost tube through which solid or aqueous sample is carried in a third argon stream. A sample is progressively desolvated, atomized and ionized. The torch is operated at atmospheric pressure. To reach the reduced pressures of mass spectrometers, ions are extracted through a series of two, approximately one millimeter wide, circular apertures set in water cooled metal cones. The space between the cones is evacuated to approximately one torr. The space behind the second cone is pumped down to, or near to, the pressure needed for the mass spectrometer (MS). The first cone, called the sampler, is placed directly in the plasma plume and its position is adjusted to the point where atomic ions are most abundant. The hot plasma gas expands through the sampler orifice and in this expansion is placed the second cone, called the skimmer. After the skimmer traditional MS designs are employed, i.e. quadrupoles, magnetic sectors, time-of-flight. ICP-MS is the leading trace element analysis technique. One of its weaknesses are polyatomic ions. This dissertation has added to the fundamental understanding of some of these polyatomic ions, their origins and behavior. Although mainly continuing the work of others, certain novel approaches have been introduced here. Chapter 2 includes the first reported efforts to include high temperature corrections to the partition functions of the polyatomic ions in ICP-MS. This and other objections to preceeding papers in this area were addressed. Errors in the measured T{sub gas} values were found for given errors in the experimental and spectroscopic values. The ionization energy of the neutral polyatomic ion was included in calculations to prove the validity of ignoring more complicated equilibria. Work was begun on the question of agreement between kinetics of the plasma and interface and the increase and depletion seen in certain polyatomic ions. This dissertation was also the first to report day to day ranges for T{sub gas} values and to use a statistical test to compare different operating conditions. This will help guide comparisons of previous and future work. Chapter 4 was the first attempt to include the excited electronic state 2 in the partition function of ArO{sup +} as well as the first to address the different dissociation products of the ground and first electronic levels of ArO{sup +}. Chapter 5 reports an interesting source of memory in ICP-MS that could affect mathematical corrections for polyatomic ions. For future work on these topics I suggest the following experiments and investigations. Clearly not an extensive list, they are instead the first topics curiosity brings to mind. (1) Measurement of T{sub gas} values when using the flow injection technique of Appendix B. It was believed that there was a fundamental difference in the plasma when the auto-sampler was used versus a continuous injection. Is this reflected in T{sub gas} values? (2) The work of Chapter 3 can be expanded and supplemented with more trials, new cone materials (i.e. copper, stainless steel) and more cone geometries. Some of this equipment is already present in the laboratory, others could be purchased or made. (3) T{sub gas} values from Chapter 3 could be correlated with instrument pressures during the experiment. Pressures after the skimmer cone were recorded for many days but have yet to be collated with the measured T{sub gas} values. (4) The work in Chapter 5 could be expanded to include more metals. Does the curious correlation between measured T{sub gas} and element boili

  10. Production of highly-enriched 134Ba for a reference material for isotope dilution mass spectrometry measurements

    SciTech Connect (OSTI)

    J.J. Horkley; K.P E.M. Gantz; J.E. Davis; R.R. Lewis; J.P. Crow; C.A. Poole; T.S. Grimes; J.J. Giglio

    2015-03-01

    t Isotope dilution mass spectrometry (IDMS) is an analytical technique capable of providing accurate and precise quantitation of trace isotope abundance and assay providing measurement uncertainties below 1 %. To achieve these low uncertainties, the IDMS method ideally utilizes chemically pure ‘‘spike’’ solutions that consist of a single highly enriched isotope that is well-characterized relating to the abundance of companion isotopes and concentration in solution. To address a current demand for accurate 137Cs/137Ba ratio measurements for ‘‘age’’ determination of radioactive 137Cs sources, Idaho National Laboratory (INL) is producing enriched 134Ba isotopes that are tobe used for IDMS spikes to accurately determine 137Ba accumulation from the decay of 137Cs. The final objective of this work it to provide a homogenous set of reference materials that the National Institute of Standards and Technology can certify as standard reference materials used for IDMS. The process that was developed at INL for the separation and isolation of Ba isotopes, chemical purification of the isotopes in solution,

  11. Production of highly-enriched 134Ba for a reference material for isotope dilution mass spectrometry measurements

    SciTech Connect (OSTI)

    Horkley, J. J.; Carney, K. P.; Gantz, E. M.; Davies, J. E.; Lewis, R. R.; Crow, J. P.; Poole, C. A.; Grimes, T. S.; Giglio, J. J.

    2015-03-17

    Isotope dilution mass spectrometry (IDMS) is an analytical technique capable of providing accurate and precise quantitation of trace isotope abundance and assay providing measurement uncertainties below 1 %. To achieve these low uncertainties, the IDMS method ideally utilizes chemically pure “spike” solutions that consist of a single highly enriched isotope that is well-characterized relating to the abundance of companion isotopes and concentration in solution. To address a current demand for accurate 137Cs/137Ba ratio measurements for “age” determination of radioactive 137Cs sources, Idaho National Laboratory (INL) is producing enriched 134Ba isotopes that are tobe used for IDMS spikes to accurately determine 137Ba accumulation from the decay of 137Cs. The final objective of this work it to provide a homogenous set of reference materials that the National Institute of Standards and Technology can certify as standard reference materials used for IDMS. The process that was developed at INL for the separation and isolation of Ba isotopes, chemical purification of the isotopes in solution, and the encapsulation of the materials will be described.

  12. Production of highly-enriched 134Ba for a reference material for isotope dilution mass spectrometry measurements

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Horkley, J. J.; Carney, K. P.; Gantz, E. M.; Davies, J. E.; Lewis, R. R.; Crow, J. P.; Poole, C. A.; Grimes, T. S.; Giglio, J. J.

    2015-03-17

    Isotope dilution mass spectrometry (IDMS) is an analytical technique capable of providing accurate and precise quantitation of trace isotope abundance and assay providing measurement uncertainties below 1 %. To achieve these low uncertainties, the IDMS method ideally utilizes chemically pure “spike” solutions that consist of a single highly enriched isotope that is well-characterized relating to the abundance of companion isotopes and concentration in solution. To address a current demand for accurate 137Cs/137Ba ratio measurements for “age” determination of radioactive 137Cs sources, Idaho National Laboratory (INL) is producing enriched 134Ba isotopes that are tobe used for IDMS spikes to accurately determinemore » 137Ba accumulation from the decay of 137Cs. The final objective of this work it to provide a homogenous set of reference materials that the National Institute of Standards and Technology can certify as standard reference materials used for IDMS. The process that was developed at INL for the separation and isolation of Ba isotopes, chemical purification of the isotopes in solution, and the encapsulation of the materials will be described.« less

  13. Determination of total and isotopic uranium by inductively coupled plasma-mass spectrometry at the Fernald Environmental Management Project

    SciTech Connect (OSTI)

    Miller, F.L.; Bolin, R.N.; Feller, M.T.; Danahy, R.J.

    1995-04-01

    At the Fernald Environmental Management Project (FEMP) in southwestern Ohio, ICP-mass spectrometry (ICP-MS), with sample introduction by peristaltic pumping, is used to determine total and isotopic uranium (U-234, U-235, U-236 and U-238) in soil samples. These analyses are conducted in support of the environmental cleanup of the FEMP site. Various aspects of the sample preparation and instrumental analysis will be discussed. Initial sample preparation consists of oven drying to determine moisture content, and grinding and rolling to homogenize the sample. This is followed by a nitric/hydrofluoric acid digestion to bring the uranium in the sample into solution. Bismuth is added to the sample prior to digestion to monitor for losses. The total uranium (U-238) content of this solution and the U{sup 235}/U{sup 238} ratio are measured on the first pass through the ICP-MS. To determine the concentration of the less abundant U{sup 234} and U{sup 236} isotopes, the digestate is further concentrated by using Eichrom TRU-Spec extraction columns before the second pass through the ICP-MS. Quality controls for both the sample preparation and instrumental protocols will also be discussed. Finally, an explanation of the calculations used to report the data in either weight percent or activity units will be given.

  14. Production of highly-enriched 134Ba for a reference material for isotope dilution mass spectrometry measurements

    SciTech Connect (OSTI)

    Horkley, J. J.; Carney, K. P.; Gantz, E. M.; Davies, J. E.; Lewis, R. R.; Crow, J. P.; Poole, C. A.; Grimes, T. S.; Giglio, J. J.

    2015-03-17

    Isotope dilution mass spectrometry (IDMS) is an analytical technique capable of providing accurate and precise quantitation of trace isotope abundance and assay providing measurement uncertainties below 1 %. To achieve these low uncertainties, the IDMS method ideally utilizes chemically pure “spike” solutions that consist of a single highly enriched isotope that is well-characterized relating to the abundance of companion isotopes and concentration in solution. To address a current demand for accurate 137Cs/137Ba ratio measurements for “age” determination of radioactive 137Cs sources, Idaho National Laboratory (INL) is producing enriched 134Ba isotopes that are tobe used for IDMS spikes to accurately determine 137Ba accumulation from the decay of 137Cs. The final objective of this work it to provide a homogenous set of reference materials that the National Institute of Standards and Technology can certify as standard reference materials used for IDMS. The process that was developed at INL for the separation and isolation of Ba isotopes, chemical purification of the isotopes in solution, and the encapsulation of the materials will be described.

  15. Determination of total chlorine and bromine in solid wastes by sintering and inductively coupled plasma-sector field mass spectrometry

    SciTech Connect (OSTI)

    Osterlund, Helene Rodushkin, Ilia; Ylinenjaervi, Karin; Baxter, Douglas C.

    2009-04-15

    A sample preparation method based on sintering, followed by analysis by inductively coupled plasma-sector field mass spectrometry (ICP-SFMS) for the simultaneous determination of chloride and bromide in diverse and mixed solid wastes, has been evaluated. Samples and reference materials of known composition were mixed with a sintering agent containing Na{sub 2}CO{sub 3} and ZnO and placed in an oven at 560 deg. C for 1 h. After cooling, the residues were leached with water prior to a cation-exchange assisted clean-up. Alternatively, a simple microwave-assisted digestion using only nitric acid was applied for comparison. Thereafter the samples were prepared for quantitative analysis by ICP-SFMS. The sintering method was evaluated by analysis of certified reference materials (CRMs) and by comparison with US EPA Method 5050 and ion chromatography with good agreement. Median RSDs for the sintering method were determined to 10% for both chlorine and bromine, and median recovery to 96% and 97%, respectively. Limits of detection (LODs) were 200 mg/kg for chlorine and 20 mg/kg for bromine. It was concluded that the sintering method is suitable for chlorine and bromine determination in several matrices like sewage sludge, plastics, and edible waste, as well as for waste mixtures. The sintering method was also applied for determination of other elements present in anionic forms, such as sulfur, arsenic, selenium and iodine.

  16. Quantifying Uranium Isotope Ratios Using Resonance Ionization Mass Spectrometry: The Influence of Laser Parameters on Relative Ionization Probability

    SciTech Connect (OSTI)

    Isselhardt, B H

    2011-09-06

    Resonance Ionization Mass Spectrometry (RIMS) has been developed as a method to measure relative uranium isotope abundances. In this approach, RIMS is used as an element-selective ionization process to provide a distinction between uranium atoms and potential isobars without the aid of chemical purification and separation. We explore the laser parameters critical to the ionization process and their effects on the measured isotope ratio. Specifically, the use of broad bandwidth lasers with automated feedback control of wavelength was applied to the measurement of {sup 235}U/{sup 238}U ratios to decrease laser-induced isotopic fractionation. By broadening the bandwidth of the first laser in a 3-color, 3-photon ionization process from a bandwidth of 1.8 GHz to about 10 GHz, the variation in sequential relative isotope abundance measurements decreased from >10% to less than 0.5%. This procedure was demonstrated for the direct interrogation of uranium oxide targets with essentially no sample preparation. A rate equation model for predicting the relative ionization probability has been developed to study the effect of variation in laser parameters on the measured isotope ratio. This work demonstrates that RIMS can be used for the robust measurement of uranium isotope ratios.

  17. Recommendations for mass spectrometry data quality metrics for open access data(corollary to the Amsterdam principles)

    SciTech Connect (OSTI)

    Kingsinger, Christopher R.; Apffel, James; Baker, Mark S.; Bian, Xiaopeng; Borchers, Christoph H.; Bradshaw, Ralph A.; Brusniak, Mi-Youn; Chan, Daniel W.; Deutsch, Eric W.; Domon, Bruno; Gorman, Jeff; Grimm, Rudolf; Hancock, William S.; Hermjakob, Henning; Horn, David; Hunter, Christie; Kolar, Patrik; Kraus, Hans-Joachim; Langen, Hanno; Linding, Rune; Moritz, Robert L.; Omenn, Gilbert S.; Orlando, Ron; Pandey, Akhilesh; Ping, Peipei; Rahbar, Amir; Rivers, Robert; Seymour, Sean L.; Simpson, Richard J.; Slotta, Douglas; Smith, Richard D.; Stein, Stephen E.; Tabb, David L.; Tagle, Danilo; Yates, John R.; Rodriguez, Henry

    2011-12-01

    Policies supporting the rapid and open sharing of proteomic data are being implemented by the leading journals in the field. The proteomics community is taking steps to ensure that data are made publicly accessible and are of high quality, a challenging task that requires the development and deployment of methods for measuring and documenting data quality metrics. On September 18, 2010, the U.S. National Cancer Institute (NCI) convened the 'International Workshop on Proteomic Data Quality Metrics' in Sydney, Australia, to identify and address issues facing the development and use of such methods for open access proteomics data. The stakeholders at the workshop enumerated the key principles underlying a framework for data quality assessment in mass spectrometry data that will meet the needs of the search community, journals, funding agencies, and data repositories. Attendees discussed and agreed upon two primary needs for the wide use of quality metrics: (i)an evolving list of comprehensive quality metrics and (ii)standards accompanied by software analytics. Attendees stressed the importance of increased education and training programs to promote reliable protocols in proteomics. This workshop report explores the historic precedents, key discussions, and necessary next steps to enhance the quality of open access data. By agreement, this article is published simultaneously in Proteomics, Proteomics Clinical Applications, Journal of Proteome Research, and Molecular and Cellular Proteomics, as a public service to the research community.The peer review process was a coordinated effort conducted by a panel of referees selected by the journals.

  18. A Rational Approach for Discovering and Validating Cancer Markers in Very Small Samples Using Mass Spectrometry and ELISA Microarrays

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Zangar, Richard C.; Varnum, Susan M.; Covington, Chandice Y.; Smith, Richard D.

    2004-01-01

    Identifying useful markers of cancer can be problematic due to limited amounts of sample. Some samples such as nipple aspirate fluid (NAF) or early-stage tumors are inherently small. Other samples such as serum are collected in larger volumes but archives of these samples are very valuable and only small amounts of each sample may be available for a single study. Also, given the diverse nature of cancer and the inherent variability in individual protein levels, it seems likely that the best approach to screen for cancer will be to determine the profile of a battery of proteins. As a result,more » a major challenge in identifying protein markers of disease is the ability to screen many proteins using very small amounts of sample. In this review, we outline some technological advances in proteomics that greatly advance this capability. Specifically, we propose a strategy for identifying markers of breast cancer in NAF that utilizes mass spectrometry (MS) to simultaneously screen hundreds or thousands of proteins in each sample. The best potential markers identified by the MS analysis can then be extensively characterized using an ELISA microarray assay. Because the microarray analysis is quantitative and large numbers of samples can be efficiently analyzed, this approach offers the ability to rapidly assess a battery of selected proteins in a manner that is directly relevant to traditional clinical assays.« less

  19. Detection of high molecular weight organic tracers in vegetation smoke samples by high-temperature gas chromatography-mass spectrometry

    SciTech Connect (OSTI)

    Elias, V.O.; Simoneit, B.R.T. ); Pereira, A.S.; Cardoso, J.N. ); Cabral, J.A. )

    1999-07-15

    High-temperature high-resolution gas chromatography (HTGC) is an established technique for the separation of complex mixtures of high molecular weight (HMW) compounds which do not elute when analyzed on conventional GC columns. The combination of this technique with mass spectrometry is not so common and application to aerosols is novel. The HTGC and HTGC-MS analyses of smoke samples taken by particle filtration from combustion of different species of plants provided the characterization of various classes of HMW compounds reported to occur for the first time in emissions from biomass burning. Among these components are a series of wax esters with up to 58 carbon numbers, aliphatic hydrocarbons, triglycerides, long chain methyl ketones, alkanols and a series of triterpenyl fatty acid esters which have been characterized as novel natural products. Long chain fatty acids with more than 32 carbon numbers are not present in the smoke samples analyzed. The HMW compounds in smoke samples from the burning of plants from Amazonia indicate the input of directly volatilized natural products in the original plants during their combustion. However, the major organic compounds extracted from smoke consist of a series of lower molecular weight polar components, which are not natural products but the result of the thermal breakdown of cellulose and lignin. In contrast, the HMW natural products may be suitable tracers for specific sources of vegetation combustion because they are emitted as particles without thermal alternation in the smoke and can thus be related directly to the original plant material.

  20. Enhancing Biological Analyses with Three Dimensional Field Asymmetric Ion Mobility, Low Field Drift Time Ion Mobility and Mass Spectrometry (µFAIMS/IMS-MS) Separations

    SciTech Connect (OSTI)

    Zhang, Xing; Ibrahim, Yehia M.; Chen, Tsung-Chi; Kyle, Jennifer E.; Norheim, Randolph V.; Monroe, Matthew E.; Smith, Richard D.; Baker, Erin Shammel

    2015-06-30

    We report the first evaluation of a platform coupling a high speed field asymmetric ion mobility spectrometry microchip (µFAIMS) with drift tube ion mobility and mass spectrometry (IMS-MS). The µFAIMS/IMS-MS platform was used to analyze biological samples and simultaneously acquire multidimensional information of detected features from the measured FAIMS compensation fields and IMS drift times, while also obtaining accurate ion masses. These separations thereby increase the overall separation power, resulting increased information content, and provide more complete characterization of more complex samples. The separation conditions were optimized for sensitivity and resolving power by the selection of gas compositions and pressures in the FAIMS and IMS separation stages. The resulting performance provided three dimensional separations, benefitting both broad complex mixture studies and targeted analyses by e.g. improving isomeric separations and allowing detection of species obscured by “chemical noise” and other interfering peaks.

  1. Chemistry of α-pinene and naphthalene oxidation products generated in a Potential Aerosol Mass (PAM) chamber as measured by acetate chemical ionization mass spectrometry

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Chhabra, P. S.; Lambe, A. T.; Canagaratna, M. R.; Stark, H.; Jayne, J. T.; Onasch, T. B.; Davidovits, P.; Kimmel, J. R.; Worsnop, D. R.

    2014-07-01

    Recent developments in high resolution, time-of-flight chemical ionization mass spectrometry (HR-ToF-CIMS) have made possible the direct detection of atmospheric organic compounds in real-time with high sensitivity and with little or no fragmentation, including low volatility, highly oxygenated organic vapors that are precursors to secondary organic aerosol formation. Here, for the first time, we examine gas-phase O3 and OH oxidation products of α-pinene and naphthalene formed in the PAM flow reactor with an HR-ToF-CIMS using acetate reagent ion chemistry. Integrated OH exposures ranged from 1.2 × 1011 to 9.7 × 1011 molec cm−3 s, corresponding to approximately 1.0 to 7.5 daysmore » of equivalent atmospheric oxidation. Measured gas-phase organic acids are similar to those previously observed in environmental chamber studies. For both precursors, we find that acetate-CIMS spectra capture both functionalization (oxygen addition) and fragmentation (carbon loss) as a function of OH exposure. The level of fragmentation is observed to increase with increased oxidation. We present a method that estimates vapor pressures of organic molecules using the measured O/C ratio, H/C ratio, and carbon number for each compound detected by the CIMS. The predicted condensed-phase SOA average acid yields and O/C and H/C ratios agree within uncertainties with previous AMS measurements and ambient CIMS results. While acetate reagent ion chemistry is used to selectively measure organic acids, in principle this method can be applied to additional reagent ion chemistries depending on the application.« less

  2. Investigating the Synthesis of Ligated Metal Clusters in Solution Using a Flow Reactor and Electrospray Ionization Mass Spectrometry

    SciTech Connect (OSTI)

    Olivares, Astrid M.; Laskin, Julia; Johnson, Grant E.

    2014-09-18

    The scalable synthesis of subnanometer metal clusters containing an exact number of atoms is of interest due to the highly size-dependent catalytic, electronic and optical properties of these species. While significant research has been conducted on the batch preparation of clusters through reduction synthesis in solution, the processes of metal complex reduction as well as cluster nucleation, growth and post-reduction etching are still not well understood. Herein, we demonstrate a temperature-controlled flow reactor for studying cluster formation in solution at well-defined conditions. Employing this technique methanol solutions of a chloro(triphenylphosphine)gold precursor, 1,4-bis(diphenylphosphino)butane capping ligand and borane-tert-butylamine reducing agent were combined in a mixing tee and introduced into a heated capillary with an adjustable length. In this manner, the temperature dependence of the relative abundance of different ionic reactants, intermediates and products synthesized in real time was characterized using online mass spectrometry. A wide distribution of doubly and triply charged cationic gold clusters was observed as well as smaller singly charged metal-ligand complexes. The results demonstrate that temperature plays a crucial role in determining the relative population of cationic gold clusters and, in general, that higher temperature promotes the formation of doubly charged clusters and singly charged metal-ligand complexes while hindering the growth of triply charged clusters. Moreover, the distribution of clusters observed at elevated temperatures is found to be consistent with that obtained at longer reaction times at room temperature, thereby demonstrating that heating may be used to access cluster distributions characteristic of different stages of reduction synthesis in solution.

  3. Three-Dimensional Imaging of Lipids and Metabolites in Tissues by Nanospray Desorption Electrospray Ionization Mass Spectrometry

    SciTech Connect (OSTI)

    Lanekoff, Ingela T.; Burnum-Johnson, Kristin E.; Thomas, Mathew; Cha, Jeeyeon; Dey, Sudhansu K.; yang, Pengxiang; Prieto, Mari; Laskin, Julia

    2015-03-01

    Abstract Three-dimensional (3D) imaging of tissue sections is a new frontier in mass spectrometry imaging (MSI). Here we report on fast 3D imaging of lipids and metabolites associated with mouse uterine decidual cells and embryo at the implantation site on day 6 of pregnancy. 2D imaging of 16-20 serial tissue sections deposited on the same glass slide was performed using nanospray desorption electrospray ionization (nano-DESI) – an ambient ionization technique that enables sensitive localized analysis of analytes on surfaces without special sample pre-treatment. In this proof-of-principle study, nano-DESI was coupled to a high-resolution Q-Exactive instrument operated at high repetition rate of >5 Hz with moderate mass resolution of 35,000 (m/?m at m/z 200), which enabled acquisition of the entire 3D image with a spatial resolution of ~150 ?m in less than 4.5 hours. The results demonstrate localization of acetylcholine in the primary decidual zone (PDZ) of the implantation site throughout the depth of the tissue examined, indicating an important role of this signaling molecule in decidualization. Choline and phosphocholine – metabolites associated with cell growth – are enhanced in the PDZ and abundant in other cellular regions of the implantation site. Very different 3D distributions were obtained for fatty acids (FA), oleic acid and linoleic acid (FA 18:1 and FA 18:2), differing only by one double bond. Localization of FA 18:2 in the PDZ indicates its important role in decidualization while FA 18:1 is distributed more evenly throughout the tissue. In contrast, several lysophosphatidylcholines (LPC) observed in this study show donut-like distributions with localization around the PDZ. Complementary distributions with minimal overlap were observed for LPC 18:0 and FA 18:2 while the 3D image of the potential precursor phosphatidylcholine (PC 36:2) showed a significant overlap with both LPC 18:0 and FA 18:2.

  4. New insights into low-temperature oxidation of propane from synchrotron photoionization mass spectrometry and multi-scale informatics modeling

    SciTech Connect (OSTI)

    Welz, Oliver; Burke, Michael P.; Antonov, Ivan O.; Goldsmith, C. Franklin; Savee, John David; Osborn, David L.; Taatjes, Craig A.; Klippenstein, Stephen J.; Sheps, Leonid

    2015-04-10

    We studied low-temperature propane oxidation at P = 4 Torr and T = 530, 600, and 670 K by time-resolved multiplexed photoionization mass spectrometry (MPIMS), which probes the reactants, intermediates, and products with isomeric selectivity using tunable synchrotron vacuum UV ionizing radiation. The oxidation is initiated by pulsed laser photolysis of oxalyl chloride, (COCl)2, at 248 nm, which rapidly generates a ~1:1 mixture of 1-propyl (n-propyl) and 2-propyl (i-propyl) radicals via the fast Cl + propane reaction. At all three temperatures, the major stable product species is propene, formed in the propyl + O2 reactions by direct HO2 elimination from both n- and i-propyl peroxy radicals. The experimentally derived propene yields relative to the initial concentration of Cl atoms are (20 ± 4)% at 530 K, (55 ± 11)% at 600 K, and (86 ± 17)% at 670 K at a reaction time of 20 ms. The lower yield of propene at low temperature reflects substantial formation of propyl peroxy radicals, which do not completely decompose on the experimental time scale. In addition, C3H6O isomers methyloxirane, oxetane, acetone, and propanal are detected as minor products. Our measured yields of oxetane and methyloxirane, which are coproducts of OH radicals, suggest a revision of the OH formation pathways in models of low-temperature propane oxidation. The experimental results are modeled and interpreted using a multiscale informatics approach, presented in detail in a separate publication (Burke, M. P.; Goldsmith, C. F.; Klippenstein, S. J.; Welz, O.; Huang H.; Antonov I. O.; Savee J. D.; Osborn D. L.; Zádor, J.; Taatjes, C. A.; Sheps, L. Multiscale Informatics for Low-Temperature Propane Oxidation: Further Complexities in Studies of Complex Reactions. J. Phys. Chem A. 2015, DOI: 10.1021/acs.jpca.5b01003). Additionally, we found that the model predicts the time profiles and yields of the experimentally observed primary products well, and shows satisfactory agreement for products formed mostly via secondary radical–radical reactions.

  5. New Insights into Low-Temperature Oxidation of Propane from Synchrotron Photoionization Mass Spectrometry and Multi-Scale Informatics Modeling

    SciTech Connect (OSTI)

    Welz, Oliver; Burke, Michael P.; Antonov, Ivan O.; Goldsmith, C. Franklin; Savee, John David; Osborn, David L.; Taatjes, Craig A.; Klippenstein, Stephen J.; Sheps, Leonid

    2015-04-10

    We studied low-temperature propane oxidation at P = 4 Torr and T = 530, 600, and 670 K by time-resolved multiplexed photoionization mass spectrometry (MPIMS), which probes the reactants, intermediates, and products with isomeric selectivity using tunable synchrotron vacuum UV ionizing radiation. The oxidation is initiated by pulsed laser photolysis of oxalyl chloride, (COCl)2, at 248 nm, which rapidly generates a ~1:1 mixture of 1-propyl (n-propyl) and 2-propyl (i-propyl) radicals via the fast Cl + propane reaction. At all three temperatures, the major stable product species is propene, formed in the propyl + O2 reactions by direct HO2 elimination from both n- and i-propyl peroxy radicals. The experimentally derived propene yields relative to the initial concentration of Cl atoms are (20 ± 4)% at 530 K, (55 ± 11)% at 600 K, and (86 ± 17)% at 670 K at a reaction time of 20 ms. The lower yield of propene at low temperature reflects substantial formation of propyl peroxy radicals, which do not completely decompose on the experimental time scale. In addition, C3H6O isomers methyloxirane, oxetane, acetone, and propanal are detected as minor products. Our measured yields of oxetane and methyloxirane, which are coproducts of OH radicals, suggest a revision of the OH formation pathways in models of low-temperature propane oxidation. The experimental results are modeled and interpreted using a multiscale informatics approach, presented in detail in a separate publication (Burke, M. P.; Goldsmith, C. F.; Klippenstein, S. J.; Welz, O.; Huang H.; Antonov I. O.; Savee J. D.; Osborn D. L.; Zádor, J.; Taatjes, C. A.; Sheps, L. Multiscale Informatics for Low-Temperature Propane Oxidation: Further Complexities in Studies of Complex Reactions. J. Phys. Chem A. 2015, DOI: 10.1021/acs.jpca.5b01003). Additionally, we found that the model predicts the time profiles and yields of the experimentally observed primary products well, and shows satisfactory agreement for products formed mostly via secondary radical–radical reactions.

  6. New insights into low-temperature oxidation of propane from synchrotron photoionization mass spectrometry and multi-scale informatics modeling

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Welz, Oliver; Burke, Michael P.; Antonov, Ivan O.; Goldsmith, C. Franklin; Savee, John David; Osborn, David L.; Taatjes, Craig A.; Klippenstein, Stephen J.; Sheps, Leonid

    2015-04-10

    We studied low-temperature propane oxidation at P = 4 Torr and T = 530, 600, and 670 K by time-resolved multiplexed photoionization mass spectrometry (MPIMS), which probes the reactants, intermediates, and products with isomeric selectivity using tunable synchrotron vacuum UV ionizing radiation. The oxidation is initiated by pulsed laser photolysis of oxalyl chloride, (COCl)2, at 248 nm, which rapidly generates a ~1:1 mixture of 1-propyl (n-propyl) and 2-propyl (i-propyl) radicals via the fast Cl + propane reaction. At all three temperatures, the major stable product species is propene, formed in the propyl + O2 reactions by direct HO2 elimination frommore » both n- and i-propyl peroxy radicals. The experimentally derived propene yields relative to the initial concentration of Cl atoms are (20 ± 4)% at 530 K, (55 ± 11)% at 600 K, and (86 ± 17)% at 670 K at a reaction time of 20 ms. The lower yield of propene at low temperature reflects substantial formation of propyl peroxy radicals, which do not completely decompose on the experimental time scale. In addition, C3H6O isomers methyloxirane, oxetane, acetone, and propanal are detected as minor products. Our measured yields of oxetane and methyloxirane, which are coproducts of OH radicals, suggest a revision of the OH formation pathways in models of low-temperature propane oxidation. The experimental results are modeled and interpreted using a multiscale informatics approach, presented in detail in a separate publication (Burke, M. P.; Goldsmith, C. F.; Klippenstein, S. J.; Welz, O.; Huang H.; Antonov I. O.; Savee J. D.; Osborn D. L.; Zádor, J.; Taatjes, C. A.; Sheps, L. Multiscale Informatics for Low-Temperature Propane Oxidation: Further Complexities in Studies of Complex Reactions. J. Phys. Chem A. 2015, DOI: 10.1021/acs.jpca.5b01003). Additionally, we found that the model predicts the time profiles and yields of the experimentally observed primary products well, and shows satisfactory agreement for products formed mostly via secondary radical–radical reactions.« less

  7. Acceleration switch

    DOE Patents [OSTI]

    Abbin, Jr., Joseph P. (Albuquerque, NM); Middleton, John N. (Albuquerque, NM); Schildknecht, Harold E. (Albuquerque, NM)

    1981-01-01

    The disclosure relates to an improved acceleration switch, of the type having a mass suspended within a chamber, having little fluid damping at low g levels and high fluid damping at high g levels.

  8. Development and evaluation of supercritical fluid chromatography/mass spectrometry for polar and high-molecular-weight coal components. Technical progress report

    SciTech Connect (OSTI)

    Chess, E.K.; Smith, R.D.

    1986-01-01

    This Technical Progress Report reviews the technical progress made over the first 18 months of the program. Our goals include the design, development, and evaluation of a combined capillary column supercritical fluid chromatograph/high-performance mass spectrometer capable of analyzing high-molecular-weight polar materials and evaluating the system's potential for application in coal conversion process monitoring. The program includes not only the development and evaluation of the required instrumentation, but the development of polar fluids and compatible chromatographic stationary phases needed for efficient separation and analysis of polar and high-molecular-weight compounds. A new chromatograph/mass spectrometer interface and new mass spectrometer ion source have been designed, constructed, and evaluated using low-polarity supercritical fluids such as pentane. Results from the evaluations have been used to modify the instrumentation to improve performance. The design and fabrication of capillary flow restrictors from fused silica tubing has been explored. Research has also been conducted toward advancing the technology of fabricating high-performance chromatographic columns suitable for use with polar supercritical fluids. Results to date support our initial belief that high-resolution supercritical fluid chromatography (SFC)/high-performance mass spectrometry (MS) will provide a significantly enhanced analytical capability for broad classes of previously intractable fuel components. 10 refs., 13 figs.

  9. Improvement in Thermal-Ionization Mass Spectrometry (TIMS) using Total Flash Evaporation (TFE) method for lanthanides isotope ratio measurements in transmutation targets

    SciTech Connect (OSTI)

    Mialle, S.; Gourgiotis, A.; Aubert, M.; Stadelmann, G.; Gautier, C.; Isnard, H.

    2011-07-01

    The experiments involved in the PHENIX french nuclear reactor to obtain precise and accurate data on the total capture cross sections of the heavy isotopes and fission products require isotopic ratios measurements with uncertainty of a few per mil. These accurate isotopic ratio measurements are performed with mass spectrometer equipped with multi-collector system. The major difficulty for the analyses of these actinides and fission products is the low quantity of the initial powder enclosed in steel container (3 to 5 mg) and the very low quantities of products formed (several {mu}g) after irradiation. Specific analytical developments are performed by Thermal Ionization Mass Spectrometry (TIMS) to be able to analyse several nanograms of elements with this technique. A specific method of acquisition named Total Flash Evaporation was adapted in this study in the case of lanthanide measurements for quantity deposited on the filament in the order of 2 ng and applied on irradiated fuel. To validate the analytical approach and discuss about the accuracy of the data, the isotopic ratios obtained by TIMS are compared with other mass spectrometric techniques such as Multiple-Collector Inductively Coupled Plasma Mass Spectrometer (MC-ICPMS). (authors)

  10. Laser ablation-inductively coupled plasma-mass spectrometry: Examinations of the origins of polyatomic ions and advances in the sampling of particulates

    SciTech Connect (OSTI)

    Witte, Travis

    2011-11-30

    This dissertation provides a general introduction to Inductively coupled plasma-mass spectrometry (ICP-MS) and laser ablation (LA) sampling, with an examination of analytical challenges in the employment of this technique. It discusses the origin of metal oxide ions (MO+) in LA-ICP-MS, as well as the effect of introducing helium and nitrogen to the aerosol gas flow on the formation of these polyatomic interferences. It extends the study of polyatomic ions in LA-ICP-MS to metal argide (MAr+) species, an additional source of possible significant interferences in the spectrum. It describes the application of fs-LA-ICP-MS to the determination of uranium isotope ratios in particulate samples.

  11. Demonstration of femtosecond laser ablation inductively coupled plasma mass spectrometry for uranium isotopic measurements in U-10Mo nuclear fuel foils

    SciTech Connect (OSTI)

    Havrilla, George Joseph; Gonzalez, Jhanis

    2015-06-10

    The use of femtosecond laser ablation inductively coupled plasma mass spectrometry was used to demonstrate the feasibility of measuring the isotopic ratio of uranium directly in U-10Mo fuel foils. The measurements were done on both the flat surface and cross sections of bare and Zr clad U-10Mo fuel foil samples. The results for the depleted uranium content measurements were less than 10% of the accepted U235/238 ratio of 0.0020. Sampling was demonstrated for line scans and elemental mapping over large areas. In addition to the U isotopic ratio measurement, the Zr thickness could be measured as well as trace elemental composition if required. A number of interesting features were observed during the feasibility measurements which could provide the basis for further investigation using this methodology. The results demonstrate the feasibility of using fs-LA-ICP-MS for measuring the U isotopic ratio in U-10Mo fuel foils.

  12. Application of high-resolution time-of-flight chemical ionization mass spectrometry measurements to estimate volatility distributions of α-pinene and naphthalene oxidation products

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Chhabra, P. S.; Lambe, A. T.; Canagaratna, M. R.; Stark, H.; Jayne, J. T.; Onasch, T. B.; Davidovits, P.; Kimmel, J. R.; Worsnop, D. R.

    2015-01-05

    Recent developments in high-resolution time-of-flight chemical ionization mass spectrometry (HR-ToF-CIMS) have made it possible to directly detect atmospheric organic compounds in real time with high sensitivity and with little or no fragmentation, including low-volatility, highly oxygenated organic vapors that are precursors to secondary organic aerosol formation. Here, using ions identified by high-resolution spectra from an HR-ToF-CIMS with acetate reagent ion chemistry, we develop an algorithm to estimate the vapor pressures of measured organic acids. The algorithm uses identified ion formulas and calculated double bond equivalencies, information unavailable in quadrupole CIMS technology, as constraints for the number of possible oxygen-containing functionalmore » groups. The algorithm is tested with acetate chemical ionization mass spectrometry (acetate-CIMS) spectra of O3 and OH oxidation products of α-pinene and naphthalene formed in a flow reactor with integrated OH exposures ranged from 1.2 × 1011 to 9.7 × 1011 molec s cm−3, corresponding to approximately 1.0 to 7.5 days of equivalent atmospheric oxidation. Measured gas-phase organic acids are similar to those previously observed in environmental chamber studies. For both precursors, we find that acetate-CIMS spectra capture both functionalization (oxygen addition) and fragmentation (carbon loss) as a function of OH exposure. The level of fragmentation is observed to increase with increased oxidation. The predicted condensed-phase secondary organic aerosol (SOA) average acid yields and O/C and H/C ratios agree within uncertainties with previous chamber and flow reactor measurements and ambient CIMS results. While acetate reagent ion chemistry is used to selectively measure organic acids, in principle this method can be applied to additional reagent ion chemistries depending on the application.« less

  13. Ion mass spectrometry investigations of the discharge during reactive high power pulsed and direct current magnetron sputtering of carbon in Ar and Ar/N{sub 2}

    SciTech Connect (OSTI)

    Schmidt, S.; Greczynski, G.; Jensen, J.; Hultman, L.; Czigany, Zs.

    2012-07-01

    Ion mass spectrometry was used to investigate discharges formed during high power impulse magnetron sputtering (HiPIMS) and direct current magnetron sputtering (DCMS) of a graphite target in Ar and Ar/N{sub 2} ambient. Ion energy distribution functions (IEDFs) were recorded in time-averaged and time-resolved mode for Ar{sup +}, C{sup +}, N{sub 2}{sup +}, N{sup +}, and C{sub x}N{sub y}{sup +} ions. An increase of N{sub 2} in the sputter gas (keeping the deposition pressure, pulse width, pulse frequency, and pulse energy constant) results for the HiPIMS discharge in a significant increase in C{sup +}, N{sup +}, and CN{sup +} ion energies. Ar{sup +}, N{sub 2}{sup +}, and C{sub 2}N{sup +} ion energies, in turn, did not considerably vary with the changes in working gas composition. The HiPIMS process showed higher ion energies and fluxes, particularly for C{sup +} ions, compared to DCMS. The time evolution of the plasma species was analyzed for HiPIMS and revealed the sequential arrival of working gas ions, ions ejected from the target, and later during the pulse-on time molecular ions, in particular CN{sup +} and C{sub 2}N{sup +}. The formation of fullerene-like structured CN{sub x} thin films for both modes of magnetron sputtering is explained by ion mass-spectrometry results and demonstrated by transmission electron microscopy as well as diffraction.

  14. Orthogonal Injection Ion Funnel Interface Providing Enhanced Performance for Selected Reaction Monitoring-Triple Quadruple Mass Spectrometry

    SciTech Connect (OSTI)

    Chen, Tsung-Chi; Fillmore, Thomas L.; Prost, Spencer A.; Moore, Ronald J.; Ibrahim, Yehia M.; Smith, Richard D.

    2015-07-21

    The electrodynamic ion funnel facilitates efficient focusing and transfer of charged particles in the higher pressure regions (e.g. ion source interfaces) of mass spectrometers, and thus providing increased sensitivity. An “off-axis” ion funnel design has been developed to reduce the source contamination and interferences from, e.g. ESI droplet residue and other poorly focused neutral or charged particles with very high mass-to charge ratios. In this study a dual ion funnel interface consisting of an orthogonal higher pressure electrodynamic ion funnel (HPIF) and an ion funnel trap combined with a triple quadruple mass spectrometer was developed and characterized. An orthogonal ion injection inlet and a repeller plate electrode was used to direct ions to an ion funnel HPIF at 9-10 Torr pressure. Several critical factors for the HPIF were characterized, including the effects of RF amplitude, DC gradient and operating pressure. Compared to the triple quadrupole standard interface more than 4-fold improvement in the limit of detection for the direct quantitative MS analysis of low abundance peptides was observed. The sensitivity enhancement in liquid chromatography selected reaction monitoring (SRM) analyses of low abundance peptides spiked into a highly complex mixture was also compared with that obtained using a both commercial s-lens interface and a in-line dual ion funnel interface.

  15. Final Technical Report for DE-FG02-06ER15835: Chemical Imaging with 100nm Spatial Resolution: Combining High Resolution Flurosecence Microscopy and Ion Mobility Mass Spectrometry

    SciTech Connect (OSTI)

    Buratto, Steven K.

    2013-09-03

    We have combined, in a single instrument, high spatial resolution optical microscopy with the chemical specificity and conformational selectivity of ion mobility mass spectrometry. We discuss the design and construction of this apparatus as well as our efforts in applying this technique to thin films of molecular semiconductor materials.

  16. Molecular Characterization of Organosulfates in Organic Aerosols from Shanghai and Los Angeles Urban Areas by Nanospray-Desorption Electrospray Ionization High-Resolution Mass Spectrometry

    SciTech Connect (OSTI)

    Tao, Shikang; Lu, Xiaohui; Levac, Nicole A.; Bateman, Adam P.; Nguyen, Tran B.; Bones, David L.; Nizkorodov, Sergey; Laskin, Julia; Laskin, Alexander; Yang, Xin

    2014-08-21

    Aerosol samples collected in the urban areas of Shanghai and Los Angeles were analyzed by nanospray-desorption electrospray ionization mass spectrometry (nano-DESI MS) with high mass resolution (m/?m=100,000). Solvent mixtures of acetonitrile/water and acetonitrile/toluene were used to extract and ionize polar and non-polar compounds, respectively. A diverse mixture of oxygenated hydrocarbons, organosulfates, organonitrates, and organics with reduced nitrogen were detected in the Los Angeles sample. Majority of the organics in the Shanghai sample were detected as organosulfates. The dominant organosulfates in the two samples have distinctly different molecular characteristics. Specifically, organosulfates in the Los Angeles sample were dominated by isoprene- or monoterpene-derived products, while organosulfates of yet unknown origin in the Shanghai sample had distinctive characteristics of long aliphatic carbon chains and low degree of oxidation and unsaturation. The use of acetonitrile/toluene solvent facilitated identification of this type of organosulfates, suggesting they could be missed in previous studies relying on sample extraction using common polar solvents. The high molecular weight and low degree of unsaturation and oxidization of the organosulfates detected in the Shanghai sample suggest that they may act as surfactants, and plausibly affect the surface tension and hygroscopicity of the atmospheric particulate matter. We propose that direct esterification of carbonyl or hydroxyl compounds by sulfates or sulfuric acid in liquid phase could be the formation pathway of these special organosulfates. Long-chain alkanes from vehicle emissions might be their precursors.

  17. Applications of ICP magnetic sector multicollector mass spectrometry to basic energy research. Final report for period December 1st, 1993 - May 31st, 2000

    SciTech Connect (OSTI)

    Halliday, A.N.

    2002-05-01

    The primary aims of this research were threefold: to develop and utilize the new technique of multiple collector inductively coupled plasma mass spectrometry and apply it to problems in the earth, ocean, and environmental sciences; to develop new chronometers and improve existing chronometers to allow the accurate determination of the ages of geological features and processes; and to study natural fluid-mediated mass transfer processes and source of components in the crust and the oceans. This technique has now become the preferred method for the determination of the isotopic compositions of a variety of elements in the periodic table. The prototype instrument was used to explore a vast array of isotopic systems and demonstrate applicability to problems as different as the origin of the solar system and smelting methods in the Bronze Age. Highlights of the program are briefly summarized under the following topics: tungsten isotopes and the early solar system; trace siderophile and chalcophile element geochemistry; hafnium isotopes and the early development of the continents; evolution of lead isotopic compositions of the oceans; the isotopic composition and residence time of Hf in seawater; the isotopic compositions of Sr, Hf, Pb, and Nd in dust; U-Th disequilibrium dating of carbonates and soils; in situ U-Th disequilibrium dating of opal.

  18. Method for ultra-trace cesium isotope ratio measurements from environmental samples using thermal ionization mass spectrometry

    SciTech Connect (OSTI)

    Snow, Mathew S.; Snyder, Darin C.; Mann, Nick R.; White, Byron M.

    2015-05-01

    135Cs/137Cs isotope ratios can provide the age, origin and history of environmental Cs contamination. Relatively high precision 135Cs/137Cs isotope ratio measurements from samples containing femtogram quantities of 137Cs are needed to accurately track contamination resuspension and redistribution following environmental 137Cs releases; however, mass spectrometric analyses of environmental samples are limited by the large quantities of ionization inhibitors and isobaric interferences which are present at relatively high concentrations in the environment. We report a new approach for Cs purification from environmental samples. An initial ammonium molybdophosphate-polyacrylonitrile (AMP-PAN) column provides a robust method for extracting Cs under a wide variety of sample matrices and mass loads. Cation exchange separations using a second AMP-PAN column result in more than two orders of magnitude greater Cs/Rb separation factors than commercially available strong cation exchangers. Coupling an AMP-PAN cation exchanging step to a microcation column (AG50W resin) enables consistent 2-4% (2?) measurement errors for samples containing 3-6,000 fg 137Cs, representing the highest precision 135Cs/137Cs ratio measurements currently reported for soil samples at the femtogram level.

  19. Airborne measurements of sulfur dioxide, dimethyl sulfide, carbon disulfide, and carbonyl sulfide by isotope dilution gas chromatography/mass spectrometry

    SciTech Connect (OSTI)

    Bandy, A.R.; Thornton, D.C.; Driedger, A.R. III [Drexel Univ., Philadelphia, PA (United States)

    1993-12-01

    A gas chromatograph/mass spectrometer is described for determining atmospheric sulfur dioxide, carbon disulfide, dimethyl sulfide, and carbonyl sulfide from aircraft and ship platforms. Isotopically labelled variants of each analyte were used as internal standards to achieve high precision. The lower limit of detection for each species for an integration time of 3 min was 1 pptv for sulfur dioxide and dimethyl sulfide and 0.2 pptv for carbon disulfide and carbonyl sulfide. All four species were simultaneously determined with a sample frequency of one sample per 6 min or greater. When only one or two species were determined, a frequency of one sample per 4 min was achieved. Because a calibration is included in each sample, no separate calibration sequence was needed. Instrument warmup was only a few minutes. The instrument was very robust in field deployments, requiring little maintenance.

  20. Accelerator Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Accelerator Science Accelerator Science ReframAccelerator.jpg Particle accelerators are among the largest, most complex, and most important scientific instruments in the world....

  1. Identification of volatile butyl rubber thermal-oxidative degradation products by cryofocusing gas chromatography/mass spectrometry (cryo-GC/MS).

    SciTech Connect (OSTI)

    Smith, Jonell Nicole; White, Michael Irvin; Bernstein, Robert; Hochrein, James Michael

    2013-02-01

    Chemical structure and physical properties of materials, such as polymers, can be altered as aging progresses, which may result in a material that is ineffective for its envisioned intent. Butyl rubber formulations, starting material, and additives were aged under thermal-oxidative conditions for up to 413 total days at up to 124 %C2%B0C. Samples included: two formulations developed at Kansas City Plant (KCP) (%236 and %2310), one commercially available formulation (%2321), Laxness bromobutyl 2030 starting material, and two additives (polyethylene AC-617 and Vanax MBM). The low-molecular weight volatile thermal-oxidative degradation products that collected in the headspace over the samples were preconcentrated, separated, and detected using cryofocusing gas chromatography mass spectrometry (cryo-GC/MS). The majority of identified degradation species were alkanes, alkenes, alcohols, ketones, and aldehydes. Observations for Butyl %2310 aged in an oxygen-18 enriched atmosphere (18O2) were used to verify when the source of oxygen in the applicable degradation products was from the gaseous environment rather than the polymeric mixture. For comparison purposes, Butyl %2310 was also aged under non-oxidative thermal conditions using an argon atmosphere.

  2. Investigation of the chemical interface in the soybean–aphid and rice–bacteria interactions using MALDI-mass spectrometry imaging

    SciTech Connect (OSTI)

    Klein, Adam T.; Yagnik, Gargey B.; Hohenstein, Jessica D.; Ji, Zhiyuan; Zi, Jiachen; Reichert, Malinda D.; MacIntosh, Gustavo C.; Yang, Bing; Peters, Reuben J.; Vela, Javier; Lee, Young Jin

    2015-04-27

    Mass spectrometry imaging (MSI) is an emerging technology for high-resolution plant biology. It has been utilized to study plant–pest interactions, but limited to the surface interfaces. Here we expand the technology to explore the chemical interactions occurring inside the plant tissues. Two sample preparation methods, imprinting and fracturing, were developed and applied, for the first time, to visualize internal metabolites of leaves in matrix-assisted laser desorption ionization (MALDI)-MSI. This is also the first time nanoparticle-based ionization was implemented to ionize diterpenoid phytochemicals that were difficult to analyze with traditional organic matrices. The interactions between rice–bacterium and soybean–aphid were investigated as two model systems to demonstrate the capability of high-resolution MSI based on MALDI. Localized molecular information on various plant- or pest-derived chemicals provided valuable insight for the molecular processes occurring during the plant–pest interactions. Basically, salicylic acid and isoflavone based resistance was visualized in the soybean–aphid system and antibiotic diterpenoids in rice–bacterium interactions.

  3. Investigation of the chemical interface in the soybean–aphid and rice–bacteria interactions using MALDI-mass spectrometry imaging

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Klein, Adam T.; Yagnik, Gargey B.; Hohenstein, Jessica D.; Ji, Zhiyuan; Zi, Jiachen; Reichert, Malinda D.; MacIntosh, Gustavo C.; Yang, Bing; Peters, Reuben J.; Vela, Javier; et al

    2015-04-27

    Mass spectrometry imaging (MSI) is an emerging technology for high-resolution plant biology. It has been utilized to study plant–pest interactions, but limited to the surface interfaces. Here we expand the technology to explore the chemical interactions occurring inside the plant tissues. Two sample preparation methods, imprinting and fracturing, were developed and applied, for the first time, to visualize internal metabolites of leaves in matrix-assisted laser desorption ionization (MALDI)-MSI. This is also the first time nanoparticle-based ionization was implemented to ionize diterpenoid phytochemicals that were difficult to analyze with traditional organic matrices. The interactions between rice–bacterium and soybean–aphid were investigated asmore » two model systems to demonstrate the capability of high-resolution MSI based on MALDI. Localized molecular information on various plant- or pest-derived chemicals provided valuable insight for the molecular processes occurring during the plant–pest interactions. Basically, salicylic acid and isoflavone based resistance was visualized in the soybean–aphid system and antibiotic diterpenoids in rice–bacterium interactions.« less

  4. Effusive molecular beam-sampled Knudsen flow reactor coupled to vacuum ultraviolet single photon ionization mass spectrometry using an external free radical source

    SciTech Connect (OSTI)

    Leplat, N.; Rossi, M. J.

    2013-11-15

    A new apparatus using vacuum ultraviolet single photon ionization mass spectrometry (VUV SPIMS) of an effusive molecular beam emanating from a Knudsen flow reactor is described. It was designed to study free radical-molecule kinetics over a significant temperature range (300–630 K). Its salient features are: (1) external free radical source, (2) counterpropagating molecular beam and diffuse VUV photon beam meeting in a crossed-beam ion source of a quadrupole mass spectrometer with perpendicular ion extraction, (3) analog detection of the photocurrent of the free radical molecular cation, and (4) possibility of detecting both free radicals and closed shell species in the same apparatus and under identical reaction conditions owing to the presence of photoelectrons generated by the photoelectric effect of the used VUV-photons. The measured thermal molecular beam-to-background ratio was 6.35 ± 0.39 for Ar and 10.86 ± 1.59 for i-C{sub 4}H{sub 10} at 300 K, a factor of 2.52 and 1.50 smaller, respectively, than predicted from basic gas-dynamic considerations. Operating parameters as well as the performance of key elements of the instrument are presented and discussed. Coupled to an external free radical source a steady-state specific exit flow of 1.6 × 10{sup 11} and 5.0 × 10{sup 11} molecule s{sup ?1} cm{sup ?3} of C{sub 2}H{sub 5}{sup •} (ethyl) and t-C{sub 4}H{sub 9}{sup •} (t-butyl) free radicals have been detected using VUV SPIMS at their molecular ion m/z 29 and 57, respectively, at 300 K.

  5. Structure and Dynamics of NBD1 from CFTR Characterized Using Crystallography and Hydrogen/Deuterium Exchange Mass Spectrometry

    SciTech Connect (OSTI)

    Lewis, H.A.; Wang, C.; Zhao, X.; Hamuro, Y.; Conners, K.; Kearins, M.C.; Lu, F.; Sauder, J.M.; Molnar, K.S.; Coales, S.J.; Maloney, P.C.; Guggino, W.B.; Wetmore, D.R.; Weber, P.C.; Hunt, J.F. (SGX); (ExSAR); (Cystic); (JHU-MED); (Columbia)

    2012-04-30

    The {Delta}F508 mutation in nucleotide-binding domain 1 (NBD1) of the cystic fibrosis transmembrane conductance regulator (CFTR) is the predominant cause of cystic fibrosis. Previous biophysical studies on human F508 and {Delta}F508 domains showed only local structural changes restricted to residues 509-511 and only minor differences in folding rate and stability. These results were remarkable because {Delta}F508 was widely assumed to perturb domain folding based on the fact that it prevents trafficking of CFTR out of the endoplasmic reticulum. However, the previously reported crystal structures did not come from matched F508 and {Delta}F508 constructs, and the {Delta}F508 structure contained additional mutations that were required to obtain sufficient protein solubility. In this article, we present additional biophysical studies of NBD1 designed to address these ambiguities. Mass spectral measurements of backbone amide {sup 1}H/{sup 2}H exchange rates in matched F508 and {Delta}F508 constructs reveal that {Delta}F508 increases backbone dynamics at residues 509-511 and the adjacent protein segments but not elsewhere in NBD1. These measurements also confirm a high level of flexibility in the protein segments exhibiting variable conformations in the crystal structures. We additionally present crystal structures of a broader set of human NBD1 constructs, including one harboring the native F508 residue and others harboring the {Delta}F508 mutation in the presence of fewer and different solubilizing mutations. The only consistent conformational difference is observed at residues 509-511. The side chain of residue V510 in this loop is mostly buried in all non-{Delta}F508 structures but completely solvent exposed in all {Delta}F508 structures. These results reinforce the importance of the perturbation {Delta}F508 causes in the surface topography of NBD1 in a region likely to mediate contact with the transmembrane domains of CFTR. However, they also suggest that increased exposure of the 509-511 loop and increased dynamics in its vicinity could promote aggregation in vitro and aberrant intermolecular interactions that impede trafficking in vivo.

  6. Hydrothermal Liquefaction Oil and Hydrotreated Product from Pine Feedstock Characterized by Heteronuclear Two-Dimensional NMR Spectroscopy and FT-ICR Mass Spectrometry

    SciTech Connect (OSTI)

    Sudasinghe, Nilusha; Cort, John R.; Hallen, Richard T.; Olarte, Mariefel V.; Schmidt, Andrew J.; Schaub, Tanner

    2014-12-01

    Hydrothermal liquefaction (HTL) crude oil and hydrotreated product from pine tree farm waste (forest product residual, FPR) have been analyzed by direct infusion electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI FT-ICR MS) in both positive- and negative-ionization modes and high-resolution twodimensional heteronuclear 1H-13C NMR spectroscopy. FT-ICR MS resolves thousands of compounds in complex oils and provides unparalleled compositional details for individual molecules for identification of compound class (heteroatom content), type (number of rings plus double bonds to carbon or double bond equivalents (DBE) and carbon number (degree of alkylation). Heteronuclear 1H-13C NMR spectroscopy provides one-bond and multiple-bond correlations between pairs of 1H and 13C chemical shifts that are characteristic of different organic functional groups. Taken together this information provides a picture of the chemical composition of these oils. Pyrolysis crude oil product from pine wood was characterized for comparison. Generally, pyrolysis oil is comprised of a more diverse distribution of heteroatom classes with higher oxygen number relative to HTL oil as shown by both positive- and negative-ion ESI FT-ICR MS. A total of 300 N1, 594 O1 and 267 O2 compounds were observed as products of hydrotreatment. The relative abundance of N1O1, N1O2, N1O3, N2, N2O1, N2O2 and O3 compounds are reduced to different degrees after hydrotreatment and other higher heteroatom containing species (O4-O10, N1O4, N1O5 and N2O3) are completely removed by hydrotreatment.

  7. Technical Basis Document: A Statistical Basis for Interpreting Urinary Excretion of Plutonium Based on Accelerator Mass Spectrometry (AMS) for Selected Atoll Populations in the Marshall Islands

    SciTech Connect (OSTI)

    Bogen, K; Hamilton, T F; Brown, T A; Martinelli, R E; Marchetti, A A; Kehl, S R; Langston, R G

    2007-05-01

    We have developed refined statistical and modeling techniques to assess low-level uptake and urinary excretion of plutonium from different population group in the northern Marshall Islands. Urinary excretion rates of plutonium from the resident population on Enewetak Atoll and from resettlement workers living on Rongelap Atoll range from <1 to 8 {micro}Bq per day and are well below action levels established under the latest Department regulation 10 CFR 835 in the United States for in vitro bioassay monitoring of {sup 239}Pu. However, our statistical analyses show that urinary excretion of plutonium-239 ({sup 239}Pu) from both cohort groups is significantly positively associated with volunteer age, especially for the resident population living on Enewetak Atoll. Urinary excretion of {sup 239}Pu from the Enewetak cohort was also found to be positively associated with estimates of cumulative exposure to worldwide fallout. Consequently, the age-related trends in urinary excretion of plutonium from Marshallese populations can be described by either a long-term component from residual systemic burdens acquired from previous exposures to worldwide fallout or a prompt (and eventual long-term) component acquired from low-level systemic intakes of plutonium associated with resettlement of the northern Marshall Islands, or some combination of both.

  8. RF-Based Accelerators

    Office of Scientific and Technical Information (OSTI)

    RF-Based Accelerators for HEDP Research ∗ John W. Staples, Andrew Sessler, Roderich Keller, LBNL, Berkeley, California, Petr Ostroumov, ANL, Argonne, Illinois, Weiren Chou, Fermilab, Batavia, Illinois Abstract Accelerator-driven High-Energy Density Physics (HEDP) experiments require typically 1 nanosecond, 1 microcoulomb pulses of mass 20 ions accelerated to several MeV to produce eV-level excitations in thin targets, the "warm dense matter" regime. Traditionally the province of

  9. Current /sup 14/C measurements with the University of Washington FN tandem accelerator

    SciTech Connect (OSTI)

    Farwell, G.W.; Grootes, P.M.; Leach, D.D.; Schmidt, F.H.; Stuiver, M.

    1983-01-01

    The accelerator mass spectrometry (AMS) system shows a one-to-one relationship between sample /sup 14/C concentrations determined by AMS - and by ..beta..-counting. Measurements of unknown samples against a standard indicate that /sup 14/C concentration measurements to better than 2% can be made. For a 30-second data collection interval in a typical run of 100 intervals, the variability of the beam injected into the accelerator is ca 2%, that of the machine transmission is ca 4%, and counting statistics give 4.7% standard deviation for a sample of 80% of modern carbon.

  10. Microelectromechanical acceleration-sensing apparatus

    DOE Patents [OSTI]

    Lee, Robb M. (Albuquerque, NM); Shul, Randy J. (Albuquerque, NM); Polosky, Marc A. (Albuquerque, NM); Hoke, Darren A. (Albuquerque, NM); Vernon, George E. (Rio Rancho, NM)

    2006-12-12

    An acceleration-sensing apparatus is disclosed which includes a moveable shuttle (i.e. a suspended mass) and a latch for capturing and holding the shuttle when an acceleration event is sensed above a predetermined threshold level. The acceleration-sensing apparatus provides a switch closure upon sensing the acceleration event and remains latched in place thereafter. Examples of the acceleration-sensing apparatus are provided which are responsive to an acceleration component in a single direction (i.e. a single-sided device) or to two oppositely-directed acceleration components (i.e. a dual-sided device). A two-stage acceleration-sensing apparatus is also disclosed which can sense two acceleration events separated in time. The acceleration-sensing apparatus of the present invention has applications, for example, in an automotive airbag deployment system.

  11. Current developments in laser ablation-inductively coupled plasma-mass spectrometry for use in geology, forensics, and nuclear nonproliferation research

    SciTech Connect (OSTI)

    Messerly, Joshua D.

    2008-08-26

    This dissertation focused on new applications of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The diverse fields that were investigated show the versatility of the technique. In Chapter 2, LA-ICP-MS was used to investigate the rare earth element (REE) profiles of garnets from the Broken Hill Deposit in New South Wales, Australia. The normalized REE profiles helped to shed new light on the formation of deposits of sulfide ores. This information may be helpful in identifying the location of sulfide ore deposits in other locations. New sources of metals such as Pg, Zn, and Ag, produced from these ores, are needed to sustain our current technological society. The application of LA-ICP-MS presented in Chapter 3 is the forensics analysis of automotive putty and caulking. The elemental analysis of these materials was combined with the use of Principal Components Analysis (PCA). The PCA comparison was able to differentiate the automotive putty samples by manufacturer and lot number. The analysis of caulk was able to show a differentiation based on manufacturer, but no clear differentiation was shown by lot number. This differentiation may allow matching of evidence in the future. This will require many more analyses and the construction of a database made up of many different samples. The 4th chapter was a study of the capabilities of LA-ICP-MS for fast and precise analysis of particle ensembles for nuclear nonproliferation applications. Laser ablation has the ability to spatially resolve particle ensembles which may contain uranium or other actinides from other particles present in a sample. This is of importance in samples obtained from air on filter media. The particle ensembles of interest may be mixed in amongst dust and other particulates. A problem arises when ablating these particle ensembles directly from the filter media. Dust particles other than ones of interest may be accidentally entrained in the aerosol of the ablated particle ensemble. This would cause the analysis to be skewed. The use of a gelatin substrate allows the ablation a particle ensemble without disturbing other particles or the gelatin surface. A method to trap and ablate particles on filter paper using collodion was also investigated. The laser was used to dig through the collodion layer and into the particle ensemble. Both of these methods fix particles to allow spatial resolution of the particle ensembles. The use of vanillic acid as a possible enhancement to ablation was also studied. A vanillic acid coating of the particles fixed on top of the gelatin substrate was not found to have any positive effect on either signal intensity or precision. The mixing of vanillic acid in the collodion solution used to coat the filter paper increased ablation signal intensity by a factor of 4 to 5. There was little effect on precision, though. The collodion on filter paper method and the gelatin method of resolving particles have shown themselves to be possible tools in fighting proliferation of nuclear weapons and material. Future applications of LA-ICP-MS are only limited by the imagination of the investigator. Any material that can be ablated and aerosolized is a potential material for analysis by LA-ICP-MS. Improvements in aerosol transport, ablation chamber design, and laser focusing can make possible the ablation and analysis of very small amounts of material. This may perhaps lead to more possible uses in forensics. A similar method to the one used in Chapter 3 could perhaps be used to match drug residue to the place of origin. Perhaps a link could be made based on the elements leached from the soil by plants used to make drugs. This may have a specific pattern based on where the plant was grown. Synthetic drugs are produced in clandestine laboratories that are often times very dirty. The dust, debris, and unique materials in the lab environment could create enough variance to perhaps match drugs produced there to samples obtained off the street. Even if the match was not strong enough to be evidence, the knowledge that many samples of a drug are being produced from a similar location could help law enforcement find and shut down the lab. Future nuclear nonproliferation research would also be helped by the ability to get more analyte signal from smaller and smaller amounts of material. One possible future line of research would be to find a way to make the collodion layer as thin as possible so less laser shots are needed to get to the particle of interest. Collodion and gelatin analysis could also be used for environmental applications where spatial resolution of particles is needed. Individual particles could give information about the contaminants present in a given location. The wide versatility of LA-ICP-MS makes it a useful tool for nearly nondestructive analysis of a variety of samples and matrices.

  12. Compact mass spectrometer for plasma discharge ion analysis

    DOE Patents [OSTI]

    Tuszewski, M.G.

    1997-07-22

    A mass spectrometer and methods are disclosed for mass spectrometry which are useful in characterizing a plasma. This mass spectrometer for determining type and quantity of ions present in a plasma is simple, compact, and inexpensive. It accomplishes mass analysis in a single step, rather than the usual two-step process comprised of ion extraction followed by mass filtering. Ions are captured by a measuring element placed in a plasma and accelerated by a known applied voltage. Captured ions are bent into near-circular orbits by a magnetic field such that they strike a collector, producing an electric current. Ion orbits vary with applied voltage and proton mass ratio of the ions, so that ion species may be identified. Current flow provides an indication of quantity of ions striking the collector. 7 figs.

  13. Compact mass spectrometer for plasma discharge ion analysis

    DOE Patents [OSTI]

    Tuszewski, Michel G. (Los Alamos, NM)

    1997-01-01

    A mass spectrometer and methods for mass spectrometry which are useful in characterizing a plasma. This mass spectrometer for determining type and quantity of ions present in a plasma is simple, compact, and inexpensive. It accomplishes mass analysis in a single step, rather than the usual two-step process comprised of ion extraction followed by mass filtering. Ions are captured by a measuring element placed in a plasma and accelerated by a known applied voltage. Captured ions are bent into near-circular orbits by a magnetic field such that they strike a collector, producing an electric current. Ion orbits vary with applied voltage and proton mass ratio of the ions, so that ion species may be identified. Current flow provides an indication of quantity of ions striking the collector.

  14. Characterization of Ambient Aerosols in Mexico City during the MCMA-2003 Campaign with Aerosol Mass Spectrometry. Results from the CENICA Supersite

    SciTech Connect (OSTI)

    Salcedo, D.; Onasch, Timothy B.; Dzepina, K.; Canagaratna, M. R.; Zhang, Q.; Huffman, A. J.; DeCarlo, Peter; Jayne, J. T.; Mortimer, P.; Worsnop, Douglas R.; Kolb, C. E.; Johnson, Kirsten S.; Zuberi, Bilal M.; Marr, L.; Volkamer, Rainer M.; Molina, Luisa; Molina, Mario J.; Cardenas, B.; Bernabe, R.; Marquez, C.; Gaffney, Jeffrey S.; Marley, Nancy A.; Laskin, Alexander; Shutthanandan, V.; Xie, YuLong; Brune, W. H.; Lesher, R.; Shirley, T.; Jiminez, J. L.

    2006-03-24

    An Aerodyne Aerosol Mass Spectrometer (AMS) was deployed at the CENICA Supersite, while another was deployed in the Aerodyne Mobile Laboratory (AML) during the Mexico City Metropolitan Area field study (MCMA-2003) from March 29-May 4, 2003 to investigate particle concentrations, sources, and processes. This is the first of a series of papers reporting the AMS results from this campaign. The AMS provides real time information on mass concentration and composition of the non-refractory species in particulate matter less than 1 ?m (NR PM1) with high time and size resolution. For the first time, we report field results from a beam width probe, which was used to study the shape and mixing state of the particles and to quantify potential losses of irregular particles due to beam broadening inside the AMS. Data from this probe show that no significant amount of irregular particles was lost due to excessive beam broadening. A comparison of the CENICA and AML AMSs measurements is presented, being the first published intercomparison between two quadrupole AMSs. The speciation, and mass concentrations reported by the two AMSs compared well. In order to account for the refractory material in the aerosol, we also present measurements of Black Carbon (BC) using an aethalometer and an estimate of the aerosol soil component obtained from PIXE analysis of filters. Comparisons of (AMS + BC + soil) mass concentration with other collocated particle instruments (a LASAIR Optical Particle Counter, a Tapered Element Oscillating Microbalance (TEOM) and a DustTrack Aerosol Monitor) are also presented. The comparisons show that the (AMS + BC + soil) mass concentration during MCMC-2003 is a good approximation to the total PM??? mass concentration.

  15. Novel two-step laser ablation and ionization mass spectrometry (2S-LAIMS) of actor-spectator ice layers: Probing chemical composition of D{sub 2}O ice beneath a H{sub 2}O ice layer

    SciTech Connect (OSTI)

    Yang, Rui Gudipati, Murthy S.

    2014-03-14

    In this work, we report for the first time successful analysis of organic aromatic analytes imbedded in D{sub 2}O ices by novel infrared (IR) laser ablation of a layered non-absorbing D{sub 2}O ice (spectator) containing the analytes and an ablation-active IR-absorbing H{sub 2}O ice layer (actor) without the analyte. With these studies we have opened up a new method for the in situ analysis of solids containing analytes when covered with an IR laser-absorbing layer that can be resonantly ablated. This soft ejection method takes advantage of the tenability of two-step infrared laser ablation and ultraviolet laser ionization mass spectrometry, previously demonstrated in this lab to study chemical reactions of polycyclic aromatic hydrocarbons (PAHs) in cryogenic ices. The IR laser pulse tuned to resonantly excite only the upper H{sub 2}O ice layer (actor) generates a shockwave upon impact. This shockwave penetrates the lower analyte-containing D{sub 2}O ice layer (spectator, a non-absorbing ice that cannot be ablated directly with the wavelength of the IR laser employed) and is reflected back, ejecting the contents of the D{sub 2}O layer into the vacuum where they are intersected by a UV laser for ionization and detection by a time-of-flight mass spectrometer. Thus, energy is transmitted from the laser-absorbing actor layer into the non-absorbing spectator layer resulting its ablation. We found that isotope cross-contamination between layers was negligible. We also did not see any evidence for thermal or collisional chemistry of PAH molecules with H{sub 2}O molecules in the shockwave. We call this “shockwave mediated surface resonance enhanced subsurface ablation” technique as “two-step laser ablation and ionization mass spectrometry of actor-spectator ice layers.” This method has its roots in the well-established MALDI (matrix assisted laser desorption and ionization) method. Our method offers more flexibility to optimize both the processes—ablation and ionization. This new technique can thus be potentially employed to undertake in situ analysis of materials imbedded in diverse media, such as cryogenic ices, biological samples, tissues, minerals, etc., by covered with an IR-absorbing laser ablation medium and study the chemical composition and reaction pathways of the analyte in its natural surroundings.

  16. Molecular Characterization of S- and N-containing Organic Constituents in Ambient Aerosols by negative ion mode High-Resolution Nanospray Desorption Electrospray Ionization Mass Spectrometry: CalNex 2010 field study

    SciTech Connect (OSTI)

    O'Brien, Rachel E.; Laskin, Alexander; Laskin, Julia; Rubitschun, Caitlin L.; Surratt, Jason D.; Goldstein, Allen H.

    2014-11-27

    Samples of ambient aerosols from the 2010 California Research at the Nexus of Air Quality and Climate Change (CalNex) field study were analyzed using Nanospray Desorption Electrospray Ionization High Resolution Mass Spectrometry (nano-DESI/MS). Four samples per day were collected in Bakersfield, CA on June 20-24 with a collection time of 6 hours per sample. Four characteristic groups of organic constituents were identified in the samples: compounds containing carbon, hydrogen, and oxygen only (CHO), sulfur- (CHOS), nitrogen-(CHON), and both nitrogen- and sulfur-containing organics (CHONS). Within the groups, organonitrates, organosulfates, and nitroxy organosulfates were assigned based on accurate mass measurements and elemental ratio comparisons. Changes in the chemical composition of the aerosol samples were observed throughout the day. The number of observed CHO compounds increased in the afternoon samples, suggesting regional photochemical processing as a source. The average number of CHOS compounds had the smallest changes throughout the day, consistent with a more broadly distributed source. Both of the nitrogen-containing groups (CHON and CHONS) had greater numbers of compounds in the night and morning samples, indicating that nitrate radical chemistry was likely a source for those compounds. Most of the compounds were found in submicron particles. The size distribution of CHON compounds was bimodal. We conclude that the majority of the compounds observed were secondary in nature with both biogenic and anthropogenic sources.

  17. Accelerators, Electrodynamics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Accelerators, Electrodynamics /science-innovation/_assets/images/icon-science.jpg Accelerators, Electrodynamics National security depends on science and technology. The United States relies on Los Alamos National Laboratory for the best of both. No place on Earth pursues a broader array of world-class scientific endeavors. Applied Cathode Enhancement and Robustness Technologies (ACERT)» LANSCE The proton linear accelerator (LINAC) at LANSCE is one of the nation's most powerful proton linear

  18. Market Acceleration

    SciTech Connect (OSTI)

    Solar Energy Technologies Program

    2010-09-28

    The fact sheet summarizes the goals and activities of the DOE Solar Energy Technologies Program efforts within its market acceleration subprogram.

  19. Acceleration Fund

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    New Mexico Connect activities through the Regional Development Corporation. "This is the third round of proposals for these Venture Acceleration Fund awards, which have already...

  20. Current trends in non-accelerator particle physics: 1, Neutrino mass and oscillation. 2, High energy neutrino astrophysics. 3, Detection of dark matter. 4, Search for strange quark matter. 5, Magnetic monopole searches

    SciTech Connect (OSTI)

    He, Yudong |

    1995-07-01

    This report is a compilation of papers reflecting current trends in non-accelerator particle physics, corresponding to talks that its author was invited to present at the Workshop on Tibet Cosmic Ray Experiment and Related Physics Topics held in Beijing, China, April 4--13, 1995. The papers are entitled `Neutrino Mass and Oscillation`, `High Energy Neutrino Astrophysics`, `Detection of Dark Matter`, `Search for Strange Quark Matter`, and `Magnetic Monopole Searches`. The report is introduced by a survey of the field and a brief description of each of the author`s papers.

  1. Impurity Profiling of a Chemical Weapon Precursor for Possible Forensic Signatures by Comprehensive Two-Dimensional Gas Chromatography/Mass Spectrometry and Chemometrics

    SciTech Connect (OSTI)

    Hoggard, Jamin C.; Wahl, Jon H.; Synovec, Robert E.; Mong, Gary M.; Fraga, Carlos G.

    2010-01-15

    In this work we present the feasibility of using analytical chemical and chemometric methodologies to reveal and exploit the organic impurity profiles from commercial dimethyl methylphosphonate (DMMP) samples to illustrate the type of forensic information that may be obtained from chemical-attack evidence. Using DMMP as a model compound for a toxicant that may be used in a chemical attack, we used comprehensive two-dimensional gas chromatography mass spectrometric detection (GC × GC-TOFMS) to detect and identify trace organic impurities in six samples of commercially acquired DMMP. The GC x GC-TOFMS data were analyzed to produce impurity profiles for all six DMMP samples using 29 analyte impurities. The use of PARAFAC for the mathematical resolution of overlap GC x GC peaks ensured clean spectra for the identification of many of the detected analytes by spectral library matching. The use of statistical pairwise comparison revealed that there were trace impurities that were quantitatively similar and different among five of the six DMMP samples. Two of the DMMP samples were revealed to have identical impurity profiles by this approach. The use of nonnegative matrix factorization proved that there were five distinct DMMP sample types as illustrated by the clustering of the multiple DMMP analyses into 5 distinct clusters in the scores plots. The two indistinguishable DMMP samples were confirmed by their chemical supplier to be from the same bulk source. Sample information from the other chemical suppliers supported that the other five DMMP samples were likely from different bulk sources. These results demonstrate that the matching of synthesized products from the same source is possible using impurity profiling. In addition, the identified impurities common to all six DMMP samples provide strong evidence that basic route information can be obtained from impurity profiles. In addition, impurities that may be unique to the sole bulk manufacturer of DMMP were found in some of the DMMP samples.

  2. Linear Accelerator

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Linear Accelerator (LINAC) The core of the LANSCE facility is one of the nation's most powerful proton linear accelerators or LINAC. The LINAC at LANSCE has served the nation since 1972, providing the beam current required by all the experimental areas that support NNSA-DP and other DOE missions. The LINAC's capability to reliably deliver beam current is the key to the LANSCE's ability to do research-and thus the key to meeting NNSA and DOE mission deliverables. The LANSCE Accelerator The LANSCE

  3. ACCELERATE ENERGY

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Obama, State of the Union, Feb. 13, 2013 The U.S. Department of Energy, Council on Competitiveness and Alliance to Save Energy have joined forces to undertake in Accelerate Energy...

  4. ION ACCELERATOR

    DOE Patents [OSTI]

    Bell, J.S.

    1959-09-15

    An arrangement for the drift tubes in a linear accelerator is described whereby each drift tube acts to shield the particles from the influence of the accelerating field and focuses the particles passing through the tube. In one embodiment the drift tube is splii longitudinally into quadrants supported along the axis of the accelerator by webs from a yoke, the quadrants. webs, and yoke being of magnetic material. A magnetic focusing action is produced by energizing a winding on each web to set up a magnetic field between adjacent quadrants. In the other embodiment the quadrants are electrically insulated from each other and have opposite polarity voltages on adjacent quadrants to provide an electric focusing fleld for the particles, with the quadrants spaced sufficienily close enough to shield the particles within the tube from the accelerating electric field.

  5. Accelerator Systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Accelerator Systems Accelerator Systems MaRIE will provide in-situ dynamic observations of microstructure for transformational materials performance in extremes CONTACT Richard Sheffield (505) 667-1237 Email Revolutionizing Microstructural Physics to Empower Nuclear Energy Realizing MaRIE's full suite of capabilities requires developing and integrating a suite of probes including proton beam radiography, electron radiography and a source of hard, brilliant, and coherent photons. The preferred

  6. Universal collisional activation ion trap mass spectrometry

    DOE Patents [OSTI]

    McLuckey, S.A.; Goeringer, D.E.; Glish, G.L.

    1993-04-27

    A universal collisional activation ion trap comprises an ion trapping means containing a bath gas and having connected thereto a noise signal generator. A method of operating a universal collisional activation ion trap comprises the steps of: providing an ion trapping means; introducing into the ion trapping means a bath gas; and, generating a noise signal within the ion trapping means; introducing into the ion trapping means a substance that, when acted upon by the noise signal, undergoes collisional activation to form product ions.

  7. Universal collisional activation ion trap mass spectrometry

    DOE Patents [OSTI]

    McLuckey, Scott A. (Oak Ridge, TN); Goeringer, Douglas E. (Oak Ridge, TN); Glish, Gary L. (Oak Ridge, TN)

    1993-01-01

    A universal collisional activation ion trap comprises an ion trapping means containing a bath gas and having connected thereto a noise signal generator. A method of operating a universal collisional activation ion trap comprises the steps of: providing an ion trapping means; introducing into the ion trapping means a bath gas; and, generating a noise signal within the ion trapping means; introducing into the ion trapping means a substance that, when acted upon by the noise signal, undergoes collisional activation to form product ions.

  8. Compact accelerator

    DOE Patents [OSTI]

    Caporaso, George J. (Livermore, CA); Sampayan, Stephen E. (Manteca, CA); Kirbie, Hugh C. (Los Alamos, NM)

    2007-02-06

    A compact linear accelerator having at least one strip-shaped Blumlein module which guides a propagating wavefront between first and second ends and controls the output pulse at the second end. Each Blumlein module has first, second, and third planar conductor strips, with a first dielectric strip between the first and second conductor strips, and a second dielectric strip between the second and third conductor strips. Additionally, the compact linear accelerator includes a high voltage power supply connected to charge the second conductor strip to a high potential, and a switch for switching the high potential in the second conductor strip to at least one of the first and third conductor strips so as to initiate a propagating reverse polarity wavefront(s) in the corresponding dielectric strip(s).

  9. Fermilab | Illinois Accelerator Research Center | Illinois Accelerator

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research Center Illinois Accelerator Research Center photo: IARC The pictured Illinois Accelerator Research Center will provide approximately 83,000 square feet of technical, office and classroom space for scientists and industrial partners. More pictures of the finished building. The Illinois Accelerator Research Center (IARC) is a new accelerator research facility being built at Fermi National Accelerator Laboratory. At the Illinois Accelerator Research Center, scientists and engineers

  10. PARTICLE ACCELERATORS; ACCELERATORS; BEAM DUMPS; BENDING; CHANNELING...

    Office of Scientific and Technical Information (OSTI)

    Channeling through Bent Crystals Mack, Stephanie; Ottawa U. SLAC 43 PARTICLE ACCELERATORS; ACCELERATORS; BEAM DUMPS; BENDING; CHANNELING; CRYSTAL LATTICES; DETECTION; FORTRAN;...

  11. VLHC accelerator physics

    SciTech Connect (OSTI)

    Michael Blaskiewicz et al.

    2001-11-01

    A six-month design study for a future high energy hadron collider was initiated by the Fermilab director in October 2000. The request was to study a staged approach where a large circumference tunnel is built that initially would house a low field ({approx}2 T) collider with center-of-mass energy greater than 30 TeV and a peak (initial) luminosity of 10{sup 34} cm{sup -2}s{sup -1}. The tunnel was to be scoped, however, to support a future upgrade to a center-of-mass energy greater than 150 TeV with a peak luminosity of 2 x 10{sup 34} cm{sup -2} sec{sup -1} using high field ({approx} 10 T) superconducting magnet technology. In a collaboration with Brookhaven National Laboratory and Lawrence Berkeley National Laboratory, a report of the Design Study was produced by Fermilab in June 2001. 1 The Design Study focused on a Stage 1, 20 x 20 TeV collider using a 2-in-1 transmission line magnet and leads to a Stage 2, 87.5 x 87.5 TeV collider using 10 T Nb{sub 3}Sn magnet technology. The article that follows is a compilation of accelerator physics designs and computational results which contributed to the Design Study. Many of the parameters found in this report evolved during the study, and thus slight differences between this text and the Design Study report can be found. The present text, however, presents the major accelerator physics issues of the Very Large Hadron Collider as examined by the Design Study collaboration and provides a basis for discussion and further studies of VLHC accelerator parameters and design philosophies.

  12. Fermilab | Science | Particle Accelerators | Fermilab's Accelerator Complex

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fermilab's Accelerator Complex photo Fermilab's accelerator complex comprises seven particle accelerators and storage rings. It produces the world's most powerful, high-energy neutrino beam and provides proton beams for various experiments and R&D programs. Fermilab's accelerator complex delivers high-intensity neutrino beams and provides optimal beam for a broad range of new and existing experiments, including the Deep Underground Neutrino Experiment, Muon g-2 and Mu2e. Fermilab's

  13. Muon Collider Progress: Accelerators

    SciTech Connect (OSTI)

    Zisman, Michael S.

    2011-09-10

    A muon collider would be a powerful tool for exploring the energy-frontier with leptons, and would complement the studies now under way at the LHC. Such a device would offer several important benefits. Muons, like electrons, are point particles so the full center-of-mass energy is available for particle production. Moreover, on account of their higher mass, muons give rise to very little synchrotron radiation and produce very little beamstrahlung. The first feature permits the use of a circular collider that can make efficient use of the expensive rf system and whose footprint is compatible with an existing laboratory site. The second feature leads to a relatively narrow energy spread at the collision point. Designing an accelerator complex for a muon collider is a challenging task. Firstly, the muons are produced as a tertiary beam, so a high-power proton beam and a target that can withstand it are needed to provide the required luminosity of ~1 × 10{sup 34} cm{sup –2}s{sup –1}. Secondly, the beam is initially produced with a large 6D phase space, which necessitates a scheme for reducing the muon beam emittance (“cooling”). Finally, the muon has a short lifetime so all beam manipulations must be done very rapidly. The Muon Accelerator Program, led by Fermilab and including a number of U.S. national laboratories and universities, has undertaken design and R&D activities aimed toward the eventual construction of a muon collider. Design features of such a facility and the supporting R&D program are described.

  14. Lead Slowing Down Spectrometry Analysis of Data from Measurements on

    Office of Scientific and Technical Information (OSTI)

    Nuclear Fuel (Journal Article) | SciTech Connect Journal Article: Lead Slowing Down Spectrometry Analysis of Data from Measurements on Nuclear Fuel Citation Details In-Document Search Title: Lead Slowing Down Spectrometry Analysis of Data from Measurements on Nuclear Fuel Improved non-destructive assay of isotopic masses in used nuclear fuel would be valuable for nuclear safeguards operations associated with the transport, storage and reprocessing of used nuclear fuel. Our collaboration is

  15. Naked singularities as particle accelerators

    SciTech Connect (OSTI)

    Patil, Mandar; Joshi, Pankaj S.

    2010-11-15

    We investigate here the particle acceleration by naked singularities to arbitrarily high center of mass energies. Recently it has been suggested that black holes could be used as particle accelerators to probe the Planck scale physics. We show that the naked singularities serve the same purpose and probably would do better than their black hole counterparts. We focus on the scenario of a self-similar gravitational collapse starting from a regular initial data, leading to the formation of a globally naked singularity. It is seen that when particles moving along timelike geodesics interact and collide near the Cauchy horizon, the energy of collision in the center of mass frame will be arbitrarily high, thus offering a window to Planck scale physics.

  16. Laser driven ion accelerator

    DOE Patents [OSTI]

    Tajima, Toshiki

    2006-04-18

    A system and method of accelerating ions in an accelerator to optimize the energy produced by a light source. Several parameters may be controlled in constructing a target used in the accelerator system to adjust performance of the accelerator system. These parameters include the material, thickness, geometry and surface of the target.

  17. Laser driven ion accelerator

    DOE Patents [OSTI]

    Tajima, Toshiki

    2005-06-14

    A system and method of accelerating ions in an accelerator to optimize the energy produced by a light source. Several parameters may be controlled in constructing a target used in the accelerator system to adjust performance of the accelerator system. These parameters include the material, thickness, geometry and surface of the target.

  18. Fermilab | Science | Particle Accelerators | Leading Accelerator Technology

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Leading Accelerator Technology photo From blueprint to construction, Fermilab scientists and engineers develop particle accelerators to produce beams to take particle physics to the next level, collaborating with scientists and laboratories around the world to help build these complex machines. Researchers build accelerators to be efficient and robust along every step of the particle beam's path, from the time it's born to its termination on target. The machines themselves must be efficient,

  19. Superconducting Radiofrequency (SRF) Accelerator Cavities

    ScienceCinema (OSTI)

    Reece, Charlie

    2014-05-22

    Charlie Reece, an accelerator technology scientist, explains how superconducting radiofrequency accelerator cavities work.

  20. The CAMS Accelerator Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    state-of-the-art, accelerator-based technologies. Upper Left: The HVEC 10 MV Model FN Tandem Van de Graaff Accelerator and the lighter-ion AMS beamline. Upper Right: The NEC 1.0...

  1. Accelerating Particles with Plasma

    SciTech Connect (OSTI)

    Litos, Michael; Hogan, Mark

    2014-11-05

    Researchers at SLAC explain how they use plasma wakefields to accelerate bunches of electrons to very high energies over only a short distance. Their experiments offer a possible path for the future of particle accelerators.

  2. Accelerated Aging Studies

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Accelerated Aging Studies LA-UR -15-27339 This document is approved for public release; further dissemination unlimited Property (max) log (aging time) Property (failure) Property (time=0) Accelerated Aging Data Predicted Storage Aging Response log (predicted lifetime) Property (max) log (aging time) Property (failure) Property (time=0) Accelerated Aging Data Predicted Storage Aging Response log (predicted lifetime) Accelerated Aging Studies Factors such as temperature, pressure, or radiation

  3. About Accelerators | Jefferson Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Jefferson Lab Cryomodule Assembly A cryomodule being prepared for assembly and later installation in Jefferson Lab's accelerator. Jefferson Lab is a world leader in superconducting radiofrequency (SRF) technologies. A D D I T I O N A L L I N K S: CEBAF SRF Institute Free-Electron Laser JLab Brochures NP Brochure Accelerator Brochure top-right bottom-left-corner bottom-right-corner About Accelerators Jefferson Lab is home to two superconducting radiofrequency accelerators: the Continuous

  4. Fermilab | Science | Particle Accelerators

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Particle Accelerators PXIE As America's particle physics laboratory, Fermilab operates and builds powerful particle accelerators for investigating the smallest things human beings have ever observed. About 2,300 physicists from all over the world come to Fermilab to conduct experiments using particle accelerators. These machines not only drive discovery, they are themselves the subjects of research and innovation. Scientists and engineers at Fermilab actively advance accelerator science and

  5. Accelerator Science | Jefferson Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research Thomas Jefferson Site Office Staff Cryomodules, sections of Jefferson Lab's accelerator, are designed, assembled, tested and maintained in the Test Lab building. A D D I T I O N A L L I N K S: SRF Institute CASA Operations Injector Group CEBAF About Accelerators top-right bottom-left-corner bottom-right-corner Accelerator Science Jefferson Lab is recognized as a world leader in accelerator science. This expertise comes from the planning, building, maintaining and operating of the

  6. Fermilab | Tevatron | Accelerator

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Accelerator photo Fermilab is home to the Tevatron, once the most powerful particle accelerator in the United States and the second most powerful particle accelerator in the world. The Tevatron was the second most powerful particle accelerator in the world before it shut down on Sept. 29, 2011. It accelerated beams of protons and antiprotons to 99.999954 percent of the speed of light around a four-mile circumference. The two beams collided at the centers of two 5,000-ton detectors positioned

  7. High brightness electron accelerator

    DOE Patents [OSTI]

    Sheffield, Richard L. (Los Alamos, NM); Carlsten, Bruce E. (Los Alamos, NM); Young, Lloyd M. (Los Alamos, NM)

    1994-01-01

    A compact high brightness linear accelerator is provided for use, e.g., in a free electron laser. The accelerator has a first plurality of acclerating cavities having end walls with four coupling slots for accelerating electrons to high velocities in the absence of quadrupole fields. A second plurality of cavities receives the high velocity electrons for further acceleration, where each of the second cavities has end walls with two coupling slots for acceleration in the absence of dipole fields. The accelerator also includes a first cavity with an extended length to provide for phase matching the electron beam along the accelerating cavities. A solenoid is provided about the photocathode that emits the electons, where the solenoid is configured to provide a substantially uniform magnetic field over the photocathode surface to minimize emittance of the electons as the electrons enter the first cavity.

  8. FermilabAcceleratorCapabilities.pdf

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Illinois Accelerator Research Center - IARC Dr. Bob Kephart Director, Illinois Accelerator Research Center Dr. Charlie Cooper General Manager, Illinois Accelerator Research Center Illinois Accelerator Research Center The Illinois Accelerator Research Center (IARC) is a new accelerator research facility being built at Fermi National Accelerator Laboratory. IARC will provide a state-of-the-art facility for research, development and industrialization of particle accelerator technology. A major

  9. Optically pulsed electron accelerator

    DOE Patents [OSTI]

    Fraser, J.S.; Sheffield, R.L.

    1985-05-20

    An optically pulsed electron accelerator can be used as an injector for a free electron laser and comprises a pulsed light source, such as a laser, for providing discrete incident light pulses. A photoemissive electron source emits electron bursts having the same duration as the incident light pulses when impinged upon by same. The photoemissive electron source is located on an inside wall of a radiofrequency-powered accelerator cell which accelerates the electron burst emitted by the photoemissive electron source.

  10. Optically pulsed electron accelerator

    DOE Patents [OSTI]

    Fraser, John S. (Los Alamos, NM); Sheffield, Richard L. (Los Alamos, NM)

    1987-01-01

    An optically pulsed electron accelerator can be used as an injector for a free electron laser and comprises a pulsed light source, such as a laser, for providing discrete incident light pulses. A photoemissive electron source emits electron bursts having the same duration as the incident light pulses when impinged upon by same. The photoemissive electron source is located on an inside wall of a radio frequency powered accelerator cell which accelerates the electron burst emitted by the photoemissive electron source.

  11. Linear inductive accelerator

    SciTech Connect (OSTI)

    Bosamykin, V.S.; Gerasimov, A.I.; Pavlovskiy, A.I.

    1983-11-01

    A proposed accelerator, differing from existing ones in that it is loaded through a capacitor on a solenoid which is uniformly distributed throughout the accelerating system and connected to an independent electrical current source, is discussed. The design of the system makes it possible to improve the uniformity of the electrical field and increase the longitudinal focusing magnetic field. This is especially important for high-current accelerators.

  12. Linear induction accelerator

    SciTech Connect (OSTI)

    Bosamykin, V.S.; Pavlovskiy, A.I.

    1984-03-01

    A linear induction accelerator of charged particles, containing inductors and an acceleration circuit, characterized by the fact that, for the purpose of increasing the power of the accelerator, each inductor is made in the form of a toroidal line with distributed parameters, from one end of which in the gap of the line a ring commutator is included, and from the other end of the ine a resistor is hooked up, is described.

  13. Lab announces Venture Acceleration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Venture Acceleration Fund recipients August 11, 2009 Los Alamos, New Mexico, August 11, 2009 - Los Alamos National Laboratory has selected Adaptive Radio Technologies, Los Alamos Visualization Associates, Mesa Tech International Inc., and ThermaSun Inc. as recipients of awards from the Los Alamos National Security, LLC Venture Acceleration Fund. The Laboratory's Venture Acceleration Fund provides investments of up to $100,000 to regional entrepreneurs, companies, investors, or strategic partners

  14. From Autos to Accelerators

    Broader source: Energy.gov [DOE]

    In a town haunted by the remains of fallen automobile plants, some companies are hiring workers to put their car-manufacturing skills toward building particle accelerators.

  15. Accelerated Aging Studies

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Accelerated Aging Studies LA-UR -15-27339 This document is approved for public release; further dissemination unlimited Property (max) log (aging time) Property (failure) Property ...

  16. Market Acceleration (Fact Sheet)

    SciTech Connect (OSTI)

    Not Available

    2010-09-01

    The fact sheet summarizes the goals and activities of the DOE Solar Energy Technologies Program efforts within its market acceleration subprogram.

  17. Charged particle accelerator grating

    DOE Patents [OSTI]

    Palmer, Robert B. (Shoreham, NY)

    1986-01-01

    A readily disposable and replaceable accelerator grating for a relativistic particle accelerator. The grating is formed for a plurality of liquid droplets that are directed in precisely positioned jet streams to periodically dispose rows of droplets along the borders of a predetermined particle beam path. A plurality of lasers are used to direct laser beams into the droplets, at predetermined angles, thereby to excite the droplets to support electromagnetic accelerating resonances on their surfaces. Those resonances operate to accelerate and focus particles moving along the beam path. As the droplets are distorted or destroyed by the incoming radiation, they are replaced at a predetermined frequency by other droplets supplied through the jet streams.

  18. Quantitation of repaglinide and metabolites in mouse whole-body thin tissue sections using droplet-based liquid microjunction surface sampling-high-performance liquid chromatography-electrospray ionization tandem mass spectrometry

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Chen, Weiqi; Wang, Lifei; Van Berkel, Gary J.; Gan, Jinping; Kertesz, Vilmos

    2015-11-03

    Herein, quantitation aspects of a fully automated autosampler/HPLC-MS/MS system applied for unattended droplet-based surface sampling of repaglinide dosed thin tissue sections with subsequent HPLC separation and mass spectrometric analysis of parent drug and various drug metabolites was studied. Major organs (brain, lung, liver, kidney, muscle) from whole-body thin tissue sections and corresponding organ homogenates prepared from repaglinide dosed mice were sampled by surface sampling and by bulk extraction, respectively, and analyzed by HPLC-MS/MS. A semi-quantitative agreement between data obtained by surface sampling and that by employing organ homogenate extraction was observed. Drug concentrations obtained by the two methods followed themore » same patterns for post-dose time points (0.25, 0.5, 1 and 2 h). Drug amounts determined in the specific tissues was typically higher when analyzing extracts from the organ homogenates. Furthermore, relative comparison of the levels of individual metabolites between the two analytical methods also revealed good semi-quantitative agreement.« less

  19. RF-Based Accelerators for HEDP Research (Conference) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Conference: RF-Based Accelerators for HEDP Research Citation Details In-Document Search Title: RF-Based Accelerators for HEDP Research Accelerator-driven High-Energy Density Physics (HEDP) experiments require typically 1 nanosecond, 1 microcoulomb pulses of mass 20 ions accelerated to several MeV to produce eV-level excitations in thin targets, the warm dense matter regime. Traditionally the province of induction linacs, RF-based acceleration may be a viable alternative with recent breakthroughs

  20. High-energy accelerator for beams of heavy ions

    DOE Patents [OSTI]

    Martin, Ronald L. (La Grange, IL); Arnold, Richard C. (Chicago, IL)

    1978-01-01

    An apparatus for accelerating heavy ions to high energies and directing the accelerated ions at a target comprises a source of singly ionized heavy ions of an element or compound of greater than 100 atomic mass units, means for accelerating the heavy ions, a storage ring for accumulating the accelerated heavy ions and switching means for switching the heavy ions from the storage ring to strike a target substantially simultaneously from a plurality of directions. In a particular embodiment the heavy ion that is accelerated is singly ionized hydrogen iodide. After acceleration, if the beam is of molecular ions, the ions are dissociated to leave an accelerated singly ionized atomic ion in a beam. Extraction of the beam may be accomplished by stripping all the electrons from the atomic ion to switch the beam from the storage ring by bending it in magnetic field of the storage ring.

  1. Accelerators (5/5)

    SciTech Connect (OSTI)

    2009-07-09

    1a) Introduction and motivation 1b) History and accelerator types 2) Transverse beam dynamics 3a) Longitudinal beam dynamics 3b) Figure of merit of a synchrotron/collider 3c) Beam control 4) Main limiting factors 5) Technical challenges Prerequisite knowledge: Previous knowledge of accelerators is not required.

  2. Accelerators (4/5)

    SciTech Connect (OSTI)

    2009-07-08

    1a) Introduction and motivation 1b) History and accelerator types 2) Transverse beam dynamics 3a) Longitudinal beam dynamics 3b) Figure of merit of a synchrotron/collider 3c) Beam control 4) Main limiting factors 5) Technical challenges Prerequisite knowledge: Previous knowledge of accelerators is not required.

  3. Accelerators (3/5)

    SciTech Connect (OSTI)

    2009-07-07

    1a) Introduction and motivation 1b) History and accelerator types 2) Transverse beam dynamics 3a) Longitudinal beam dynamics 3b) Figure of merit of a synchrotron/collider 3c) Beam control 4) Main limiting factors 5) Technical challenges Prerequisite knowledge: Previous knowledge of accelerators is not required.

  4. Accelerators (5/5)

    ScienceCinema (OSTI)

    None

    2011-10-06

    1a) Introduction and motivation 1b) History and accelerator types 2) Transverse beam dynamics 3a) Longitudinal beam dynamics 3b) Figure of merit of a synchrotron/collider 3c) Beam control 4) Main limiting factors 5) Technical challenges Prerequisite knowledge: Previous knowledge of accelerators is not required.

  5. Microscale acceleration history discriminators

    DOE Patents [OSTI]

    Polosky, Marc A. (Albuquerque, NM); Plummer, David W. (Albuquerque, NM)

    2002-01-01

    A new class of micromechanical acceleration history discriminators is claimed. These discriminators allow the precise differentiation of a wide range of acceleration-time histories, thereby allowing adaptive events to be triggered in response to the severity (or lack thereof) of an external environment. Such devices have applications in airbag activation, and other safety and surety applications.

  6. Safety of Accelerator Facilities

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2001-01-08

    To establish accelerator-specific safety requirements which, when supplemented by other applicable safety and health requirements, will serve to prevent injuries and illnesses associated with Department of Energy (DOE) or National Nuclear Security Administration (NNSA) accelerator operations. Cancels DOE O 420.2. Canceled by DOE O 420.2B.

  7. Safety of Accelerator Facilities

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2004-07-23

    To establish accelerator-specific safety requirements which, when supplemented by other applicable safety and health requirements, will serve to prevent injuries and illnesses associated with Department of Energy (DOE) or National Nuclear Security Administration (NNSA) accelerator operations. Cancels DOE O 420.2A. Certified 5-13-08. Canceled by DOE O 420.2C.

  8. Accelerators (3/5)

    ScienceCinema (OSTI)

    None

    2011-10-06

    1a) Introduction and motivation 1b) History and accelerator types 2) Transverse beam dynamics 3a) Longitudinal beam dynamics 3b) Figure of merit of a synchrotron/collider 3c) Beam control 4) Main limiting factors 5) Technical challenges Prerequisite knowledge: Previous knowledge of accelerators is not required.

  9. Accelerators (4/5)

    ScienceCinema (OSTI)

    None

    2011-10-06

    1a) Introduction and motivation 1b) History and accelerator types 2) Transverse beam dynamics 3a) Longitudinal beam dynamics 3b) Figure of merit of a synchrotron/collider 3c) Beam control 4) Main limiting factors 5) Technical challenges Prerequisite knowledge: Previous knowledge of accelerators is not required.

  10. Safety of Accelerator Facilities

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-07-21

    The order defines accelerators and establishes accelerator specific safety requirements and approval authorities which, when supplemented by other applicable safety and health requirements, promote safe operations to ensure protection of workers, the public, and the environment. Supersedes DOE O 420.2B.

  11. Accelerators, Beams And Physical Review Special Topics - Accelerators And Beams

    SciTech Connect (OSTI)

    Siemann, R.H.; /SLAC

    2011-10-24

    Accelerator science and technology have evolved as accelerators became larger and important to a broad range of science. Physical Review Special Topics - Accelerators and Beams was established to serve the accelerator community as a timely, widely circulated, international journal covering the full breadth of accelerators and beams. The history of the journal and the innovations associated with it are reviewed.

  12. Methods for Neutron Spectrometry

    DOE R&D Accomplishments [OSTI]

    Brockhouse, Bertram N.

    1961-01-09

    The appropriate theories and the general philosophy of methods of measurement and treatment of data neutron spectrometry are discussed. Methods of analysis of results for liquids using the Van Hove formulation, and for crystals using the Born-von Karman theory, are reviewed. The most useful of the available methods of measurement are considered to be the crystal spectrometer methods and the pulsed monoenergetic beam/time-of-flight method. Pulsed-beam spectrometers have the advantage of higher counting rates than crystal spectrometers, especially in view of the fact that simultaneous measurements in several counters at different angles of scattering are possible in pulsed-beam spectrometers. The crystal spectrometer permits several valuable new types of specialized experiments to be performed, especially energy distribution measurements at constant momentum transfer. The Chalk River triple-axis crystal-spectrometer is discussed, with reference to its use in making the specialized experiments. The Chalk River rotating crystal (pulsed-beam) spectrometer is described, and a comparison of this type instrument with other pulsed-beam spectrometers is made. A partial outline of the theory of operation of rotating-crystal spectrometers is presented. The use of quartz-crystal filters for fast neutron elimination and for order elimination is discussed. (auth)

  13. Accelerator on a Chip

    ScienceCinema (OSTI)

    England, Joel

    2014-07-16

    SLAC's Joel England explains how the same fabrication techniques used for silicon computer microchips allowed their team to create the new laser-driven particle accelerator chips. (SLAC Multimedia Communications)

  14. Venture Acceleration Fund wins

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    aims to help entrepreneurs and businesses reach the next level of success and grow the economy in Northern New Mexico. About the Venture Acceleration Fund The VAF is a...

  15. Charged particle accelerator grating

    DOE Patents [OSTI]

    Palmer, R.B.

    1985-09-09

    A readily disposable and replaceable accelerator grating for a relativistic particle accelerator is described. The grating is formed for a plurality of liquid droplets that are directed in precisely positioned jet streams to periodically dispose rows of droplets along the borders of a predetermined particle beam path. A plurality of lasers are used to direct laser beams onto the droplets, at predetermined angles, thereby to excite the droplets to support electromagnetic accelerating resonances on their surfaces. Those resonances operate to accelerate and focus particles moving along the beam path. As the droplets are distorted or destroyed by the incoming radiation, they are replaced at a predetermined frequency by other droplets supplied through the jet streams.

  16. Breakthrough: Fermilab Accelerator Technology

    ScienceCinema (OSTI)

    None

    2014-08-12

    There are more than 30,000 particle accelerators in operation around the world. At Fermilab, scientists are collaborating with other laboratories and industry to optimize the manufacturing processes for a new type of powerful accelerator that uses superconducting niobium cavities. Experimenting with unique polishing materials, a Fermilab team has now developed an efficient and environmentally friendly way of creating cavities that can propel particles with more than 30 million volts per meter.

  17. Rolamite acceleration sensor

    DOE Patents [OSTI]

    Abbin, Joseph P. (Albuquerque, NM); Briner, Clifton F. (Albuquerque, NM); Martin, Samuel B. (Albuquerque, NM)

    1993-01-01

    A rolamite acceleration sensor which has a failsafe feature including a housing, a pair of rollers, a tension band wrapped in an S shaped fashion around the rollers, wherein the band has a force-generation cut out and a failsafe cut out or weak portion. The failsafe cut out or weak portion breaks when the sensor is subjected to an excessive acceleration so that the sensor fails in an open circuit (non-conducting) state permanently.

  18. Rolamite acceleration sensor

    DOE Patents [OSTI]

    Abbin, J.P.; Briner, C.F.; Martin, S.B.

    1993-12-21

    A rolamite acceleration sensor is described which has a failsafe feature including a housing, a pair of rollers, a tension band wrapped in an S shaped fashion around the rollers, wherein the band has a force-generation cut out and a failsafe cut out or weak portion. The failsafe cut out or weak portion breaks when the sensor is subjected to an excessive acceleration so that the sensor fails in an open circuit (non-conducting) state permanently. 6 figures.

  19. WIPP - CBFO Accelerating Cleanup

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    more information, access DOE Environmental Management site at: http://www.em.doe.gov/closure/ For more information regarding the Accelerating Cleanup: Paths to Closure, contact Freida Huckeba at (505) 234-7315. Accelerating Cleanup: Paths to Closure (PtC) This document has been provided to you in PDF format. Please install Adobe Acrobat Reader before accessing these documents. For your convenience, each section of this document contains a Table of Contents complete with internal links. Just

  20. American Venture Acceleration Fund

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    regional businesses receive Native American Venture Acceleration Fund grants February 1, 2016 Investing in Northern New Mexico's economy through jobs, new revenue LOS ALAMOS, N.M., Feb. 1, 2016-Four Northern New Mexico Native American- owned and operated businesses received a total of $60,000 in grants through a Native American Venture Acceleration Fund created by Los Alamos National Security, LLC (LANS) and the Regional Development Corporation. The grants are designed to help the recipients

  1. Native American Venture Acceleration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Native American Venture Acceleration Fund provides boost to six regional businesses February 26, 2013 LANS, LANL fostering economic development in Northern New Mexico LOS ALAMOS, New Mexico, Feb. 26, 2013-Six Native American businesses received grants through a new Native American Venture Acceleration Fund created by Los Alamos National Security, LLC (LANS) and the Regional Development Corporation. The grants are designed to help the recipients create jobs, increase their revenue base and help

  2. LANS Venture Acceleration Fund

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Venture Acceleration Fund announces "Call for Ideas" August 2, 2010 LOS ALAMOS, New Mexico, August 2, 2010-Through September 1, 2010, Northern New Mexico Connect (NNM Connect) is accepting idea statements for the Los Alamos National Security, LLC Venture Acceleration Fund (VAF). VAF invests in creating and growing Northern New Mexico businesses that have an association with Los Alamos National Laboratory technology or expertise. It invests up to $100,000 in businesses that use

  3. Open MSI : a Mass Spectrometry Imaging Science Gateway

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Gateway NERSC OSF Room 238 April 11, 2013 Ben Bowen Berkeley Lab Metabolite and protein analysis is vital to understanding the phenotype of a biological sample....

  4. Spatially resolved thermal desorption/ionization coupled with mass spectrometry

    DOE Patents [OSTI]

    Jesse, Stephen; Van Berkel, Gary J; Ovchinnikova, Olga S

    2013-02-26

    A system and method for sub-micron analysis of a chemical composition of a specimen are described. The method includes providing a specimen for evaluation and a thermal desorption probe, thermally desorbing an analyte from a target site of said specimen using the thermally active tip to form a gaseous analyte, ionizing the gaseous analyte to form an ionized analyte, and analyzing a chemical composition of the ionized analyte. The thermally desorbing step can include heating said thermally active tip to above 200.degree. C., and positioning the target site and the thermally active tip such that the heating step forms the gaseous analyte. The thermal desorption probe can include a thermally active tip extending from a cantilever body and an apex of the thermally active tip can have a radius of 250 nm or less.

  5. Monitoring Trace Radionuclides by ICP Mass Spectrometry with...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    such measurements (from hours to several minutes), while maintaining at least reasonable accuracy (agreement with true ratios +- 3% or better) and precision (1% RSD or better),...

  6. A New High-Current Proton Accelerator

    SciTech Connect (OSTI)

    Cleland, M. R.; Galloway, R. A.; DeSanto, L.; Jongen, Y.

    2009-03-10

    A high-current (>20 mA) dc proton accelerator is being developed for applications such as boron neutron capture therapy (BNCT) and the detection of explosive materials by nuclear resonance absorption (NRA) of gamma radiation. The high-voltage dc accelerator (adjustable between 1.4 and 2.8 MeV) will be a single-ended industrial Dynamitron registered system equipped with a compact high-current, microwave-driven proton source. A magnetic mass analyzer inserted between the ion source and the acceleration tube will select the protons and reject heavier ions. A sorption pump near the ion source will minimize the flow of neutral hydrogen gas into the acceleration tube. For BNCT, a lithium target for generating epithermal neutrons is being developed that will be capable of dissipating the high power (>40 kW) of the proton beam. For NRA, special targets will be used to generate gamma rays with suitable energies for exciting nuclides typically present in explosive materials. Proton accelerators with such high-current and high-power capabilities in this energy range have not been developed previously.

  7. Fermilab | Illinois Accelerator Research Center | Accelerators and Society

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Accelerators and Society Physicists have been inventing new types of accelerators to propel charged particles to higher and higher energies for more than 80 years. Today, besides their role in scientific discovery, scientists estimate that more than 30,000 accelerators are at work worldwide in areas ranging from diagnosing and treating disease to powering industrial processes. The accelerators of tomorrow promise still greater opportunities. Next-generation particle beams represent cheaper,

  8. Commissioning the GTA accelerator

    SciTech Connect (OSTI)

    Sander, O.R.; Atkins, W.H.; Bolme, G.O.; Bowling, S.; Brown, S.; Cole, R.; Gilpatrick, J.D.; Garnett, R.; Guy, F.W.; Ingalls, W.B.; Johnson, K.F.; Kerstiens, D.; Little, C.; Lohsen, R.A.; Lloyd, S.; Lysenko, W.P.; Mottershead, C.T.; Neuschaefer, G.; Power, J.; Rusthoi, D.P.; Sandoval, D.P. Stevens, R.R. Jr.; Vaughn, G.; Wadlinger, E.A.; Yuan, V.; Connolly, R.; Weiss, R.; Saadatmand, K.

    1992-09-01

    The Ground Test Accelerator (GTA) is supported by the Strategic Defense command as part of their Neutral Particle Beam (NPB) program. Neutral particles have the advantage that in space they are unaffected by the earth`s magnetic field and travel in straight lines unless they enter the earth`s atmosphere and become charged by stripping. Heavy particles are difficult to stop and can probe the interior of space vehicles; hence, NPB can function as a discriminator between warheads and decoys. We are using GTA to resolve the physics and engineering issues related to accelerating, focusing, and steering a high-brightness, high-current H{sup -} beam and then neutralizing it. Our immediate goal is to produce a 24-MeV, 50mA device with a 2% duty factor.

  9. Commissioning the GTA accelerator

    SciTech Connect (OSTI)

    Sander, O.R.; Atkins, W.H.; Bolme, G.O.; Bowling, S.; Brown, S.; Cole, R.; Gilpatrick, J.D.; Garnett, R.; Guy, F.W.; Ingalls, W.B.; Johnson, K.F.; Kerstiens, D.; Little, C.; Lohsen, R.A.; Lloyd, S.; Lysenko, W.P.; Mottershead, C.T.; Neuschaefer, G.; Power, J.; Rusthoi, D.P.; Sandoval, D.P. Stevens, R.R. Jr.; Vaughn, G.; Wadlinger, E.A.; Yuan, V. ); Connolly, R.; Weiss, R. (Gr

    1992-01-01

    The Ground Test Accelerator (GTA) is supported by the Strategic Defense command as part of their Neutral Particle Beam (NPB) program. Neutral particles have the advantage that in space they are unaffected by the earth's magnetic field and travel in straight lines unless they enter the earth's atmosphere and become charged by stripping. Heavy particles are difficult to stop and can probe the interior of space vehicles; hence, NPB can function as a discriminator between warheads and decoys. We are using GTA to resolve the physics and engineering issues related to accelerating, focusing, and steering a high-brightness, high-current H{sup -} beam and then neutralizing it. Our immediate goal is to produce a 24-MeV, 50mA device with a 2% duty factor.

  10. Accelerator research studies

    SciTech Connect (OSTI)

    Not Available

    1993-01-01

    The Accelerator Research Studies program at the University of Maryland, sponsored by the Department of Energy under grant number DE-FG05-91ER40642, is currently in the second year of a three-year funding cycle. The program consists of the following three tasks: TASK A, Study of Transport and Longitudinal Compression of Intense, High-Brightness Beams,'' (P.I., M. Reiser); TASK B, Study of Collective Ion Acceleration by Intense Electron Beams and Pseudospark Produced High Brightness Electron Beams,'' (Co-P.I.'s, W.W. Destler, M. Reiser, M.J. Rhee, and C.D. Striffler); TASK C, Study of a Gyroklystron High-Power Microwave Source for Linear Colliders,'' (Co-P.I.'s, V.L. Granatstein, W. Lawson, M. Reiser, and C.D. Striffler). In this report we document the progress that has been made during the past year for each of the three tasks.

  11. Adaptive control for accelerators

    DOE Patents [OSTI]

    Eaton, Lawrie E. (Los Alamos, NM); Jachim, Stephen P. (Los Alamos, NM); Natter, Eckard F. (Santa Fe, NM)

    1991-01-01

    An adaptive feedforward control loop is provided to stabilize accelerator beam loading of the radio frequency field in an accelerator cavity during successive pulses of the beam into the cavity. A digital signal processor enables an adaptive algorithm to generate a feedforward error correcting signal functionally determined by the feedback error obtained by a beam pulse loading the cavity after the previous correcting signal was applied to the cavity. Each cavity feedforward correcting signal is successively stored in the digital processor and modified by the feedback error resulting from its application to generate the next feedforward error correcting signal. A feedforward error correcting signal is generated by the digital processor in advance of the beam pulse to enable a composite correcting signal and the beam pulse to arrive concurrently at the cavity.

  12. Accelerators for Cancer Therapy

    DOE R&D Accomplishments [OSTI]

    Lennox, Arlene J.

    2000-05-30

    The vast majority of radiation treatments for cancerous tumors are given using electron linacs that provide both electrons and photons at several energies. Design and construction of these linacs are based on mature technology that is rapidly becoming more and more standardized and sophisticated. The use of hadrons such as neutrons, protons, alphas, or carbon, oxygen and neon ions is relatively new. Accelerators for hadron therapy are far from standardized, but the use of hadron therapy as an alternative to conventional radiation has led to significant improvements and refinements in conventional treatment techniques. This paper presents the rationale for radiation therapy, describes the accelerators used in conventional and hadron therapy, and outlines the issues that must still be resolved in the emerging field of hadron therapy.

  13. SSRL Accelerator Phycics Home Page

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    at.gif (15297 bytes) BeamOptics.gif (29047 bytes) ICFA2000t.gif (31362 bytes) Home Page LCLS Accelerator Physics at SSRL The field tha t can be covered by the Accelerator Physics...

  14. Linear Accelerator | Advanced Photon Source

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Linear Accelerator Producing brilliant x-ray beams at the APS begins with electrons emitted from a cathode heated to 1100 C. The electrons are accelerated by high-voltage...

  15. American Venture Acceleration Fund

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    February 4, 2014 LANS, LANL fostering economic development in Northern New Mexico LOS ALAMOS, N.M., Feb. 4, 2014-Six Northern New Mexico Native American-owned and operated businesses received a total of $60,000 in grants through a new Native American Venture Acceleration Fund created by Los Alamos National Security, LLC (LANS) and the Regional Development Corporation. The grants are designed to help the recipients create jobs, increase their revenue base and help diversify the area economy. - 2

  16. Accelerating Advanced Material Development

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Materials Research in the Information Age Accelerating Advanced Material Development NERSC Science Gateway a 'Google of Material Properties' October 31, 2011 Linda Vu, lvu@lbl.gov, +1 510 495 2402 Kristin Persson is one of the founding scientists behind the Materials Project, a computational tool aimed at taking the guesswork out of new materials discoveries, especially those aimed at energy applications like batteries. (Roy Kaltschmidt, LBNL) New materials are crucial to building a clean energy

  17. Linear induction accelerator

    DOE Patents [OSTI]

    Buttram, M.T.; Ginn, J.W.

    1988-06-21

    A linear induction accelerator includes a plurality of adder cavities arranged in a series and provided in a structure which is evacuated so that a vacuum inductance is provided between each adder cavity and the structure. An energy storage system for the adder cavities includes a pulsed current source and a respective plurality of bipolar converting networks connected thereto. The bipolar high-voltage, high-repetition-rate square pulse train sets and resets the cavities. 4 figs.

  18. WIPP Accelerating Cleanup

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ACCELERATING CLEANUP: PATHS TO CLOSURE CARLSBAD AREA OFFICE JUNE 1998 I. Operations/Field Overview CAO Mission The mission of the Carlsbad Area Office (CAO) is to protect human health and the environment by opening and operating the Waste Isolation Pilot Plant (WIPP) for safe disposal of transuranic (TRU) waste and by establishing an effective system for management of TRU waste from generation to disposal. It includes personnel assigned to CAO, WIPP site operations, transportation, and other

  19. Market Acceleration & Deployment

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Acceleration & Deployment - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery Testing Nuclear Fuel Cycle Defense Waste Management Programs

  20. ACCELERATION INTEGRATING MEANS

    DOE Patents [OSTI]

    Wilkes, D.F.

    1961-08-29

    An acceleration responsive device is described. A housing has at one end normally open electrical contacts and contains a piston system with a first part of non-magnetic material having metering orifices in the side walls for forming an air bearing between it and the walls of the housing; this first piston part is normally held against the other end of the housing from the noted contacts by a second piston or reset part. The reset part is of partly magnetic material, is separable from the flrst piston part, and is positioned within the housing intermediate the contacts and the first piston part. A magnet carried by the housing imposes a retaining force upon the reset part, along with a helical compression spring that is between the reset part and the end with the contacts. When a predetermined acceleration level is attained, the reset part overcomes the bias or retaining force provided by the magnet and the spring'' snaps'' into a depression in the housing adjacent the contacts. The first piston part is then free to move toward the contacts with its movement responsive tc acceleration forces and the metering orifices. (AEC)

  1. Berkeley Proton Linear Accelerator

    DOE R&D Accomplishments [OSTI]

    Alvarez, L. W.; Bradner, H.; Franck, J.; Gordon, H.; Gow, J. D.; Marshall, L. C.; Oppenheimer, F. F.; Panofsky, W. K. H.; Richman, C.; Woodyard, J. R.

    1953-10-13

    A linear accelerator, which increases the energy of protons from a 4 Mev Van de Graaff injector, to a final energy of 31.5 Mev, has been constructed. The accelerator consists of a cavity 40 feet long and 39 inches in diameter, excited at resonance in a longitudinal electric mode with a radio-frequency power of about 2.2 x 10{sup 6} watts peak at 202.5 mc. Acceleration is made possible by the introduction of 46 axial "drift tubes" into the cavity, which is designed such that the particles traverse the distance between the centers of successive tubes in one cycle of the r.f. power. The protons are longitudinally stable as in the synchrotron, and are stabilized transversely by the action of converging fields produced by focusing grids. The electrical cavity is constructed like an inverted airplane fuselage and is supported in a vacuum tank. Power is supplied by 9 high powered oscillators fed from a pulse generator of the artificial transmission line type.

  2. History of Proton Linear Accelerators

    DOE R&D Accomplishments [OSTI]

    Alvarez, L. W.

    1987-01-01

    Some personal recollections are presented that relate to the author`s experience developing linear accelerators, particularly for protons. (LEW)

  3. Sandia Energy - Conventional Water Power: Market Acceleration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Market Acceleration Home Stationary Power Energy Conversion Efficiency Water Power Conventional Water Power: Market Acceleration Conventional Water Power: Market AccelerationTara...

  4. APT accelerator. Topical report

    SciTech Connect (OSTI)

    Lawrence, G.; Rusthoi, D.

    1995-03-01

    The Accelerator Production of Tritium (APT) project, sponsored by Department of Energy Defense Programs (DOE/DP), involves the preconceptual design of an accelerator system to produce tritium for the nation`s stockpile of nuclear weapons. Tritium is an isotope of hydrogen used in nuclear weapons, and must be replenished because of radioactive decay (its half-life is approximately 12 years). Because the annual production requirements for tritium has greatly decreased since the end of the Cold War, an alternative approach to reactors for tritium production, based on a linear accelerator, is now being seriously considered. The annual tritium requirement at the time this study was undertaken (1992-1993) was 3/8 that of the 1988 goal, usually stated as 3/8-Goal. Continued reduction in the number of weapons in the stockpile has led to a revised (lower) production requirement today (March, 1995). The production requirement needed to maintain the reduced stockpile, as stated in the recent Nuclear Posture Review (summer 1994) is approximately 3/16-Goal, half the previous level. The Nuclear Posture Review also requires that the production plant be designed to accomodate a production increase (surge) to 3/8-Goal capability within five years, to allow recovery from a possible extended outage of the tritium plant. A multi-laboratory team, collaborating with several industrial partners, has developed a preconceptual APT design for the 3/8-Goal, operating at 75% capacity. The team has presented APT as a promising alternative to the reactor concepts proposed for Complex-21. Given the requirements of a reduced weapons stockpile, APT offers both significant safety, environmental, and production-fexibility advantages in comparison with reactor systems, and the prospect of successful development in time to meet the US defense requirements of the 21st Century.

  5. Naked singularities as particle accelerators. II

    SciTech Connect (OSTI)

    Patil, Mandar; Joshi, Pankaj S.; Malafarina, Daniele

    2011-03-15

    We generalize here our earlier results on particle acceleration by naked singularities. We showed recently [M. Patil and P. S. Joshi, Phys. Rev. D 82, 104049 (2010).] that the naked singularities that form due to the gravitational collapse of massive stars provide a suitable environment where particles could get accelerated and collide at arbitrarily high center-of-mass energies. However, we focused there only on the spherically symmetric gravitational collapse models, which were also assumed to be self-similar. In this paper, we broaden and generalize the result to all gravitational collapse models leading to the formation of a naked singularity as the final state of collapse, evolving from a regular initial data, without making any prior restrictive assumptions about the spacetime symmetries such as above. We show that, when the particles interact and collide near the Cauchy horizon, the energy of collision in the center-of-mass frame will be arbitrarily high, thus offering a window to the Planck scale physics. We also consider the issue of various possible physical mechanisms of generation of such very high-energy particles from the vicinity of naked singularity. We then construct a model of gravitational collapse to a timelike naked singularity to demonstrate the working of these ideas, where the pressure is allowed to be negative, but the energy conditions are respected. We show that a finite amount of mass-energy density has to be necessarily radiated away from the vicinity of the naked singularity as the collapse evolves. Therefore, the nature of naked singularities, both at the classical and quantum level, could play an important role in the process of particle acceleration, explaining the occurrence of highly energetic outgoing particles in the vicinity of the Cauchy horizon that participate in extreme high-energy collisions.

  6. Materials Classification & Accelerated Property Predictions using...

    Office of Scientific and Technical Information (OSTI)

    Materials Classification & Accelerated Property Predictions using Machine Learning Citation Details In-Document Search Title: Materials Classification & Accelerated Property...

  7. Siemens Technology Accelerator | Open Energy Information

    Open Energy Info (EERE)

    Technology Accelerator Jump to: navigation, search Name: Siemens Technology Accelerator Place: Germany Sector: Services Product: General Financial & Legal Services ( Subsidiary ...

  8. SETsquared Business Acceleration | Open Energy Information

    Open Energy Info (EERE)

    SETsquared Business Acceleration Jump to: navigation, search Name: SETsquared Business Acceleration Place: United Kingdom Sector: Services Product: General Financial & Legal...

  9. Advanced Mass Spectrometric Methods for the Rapid and Quantitative Characterization of Proteomes

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Smith, Richard D.

    2002-01-01

    Progress is reviewedmore » towards the development of a global strategy that aims to extend the sensitivity, dynamic range, comprehensiveness and throughput of proteomic measurements based upon the use of high performance separations and mass spectrometry. The approach uses high accuracy mass measurements from Fourier transform ion cyclotron resonance mass spectrometry (FTICR) to validate peptide ‘accurate mass tags’ (AMTs) produced by global protein enzymatic digestions for a specific organism, tissue or cell type from ‘potential mass tags’ tentatively identified using conventional tandem mass spectrometry (MS/MS). This provides the basis for subsequent measurements without the need for MS/ MS. High resolution capillary liquid chromatography separations combined with high sensitivity, and high resolution accurate FTICR measurements are shown to be capable of characterizing peptide mixtures of more than 10 5 components. The strategy has been initially demonstrated using the microorganisms Saccharomyces cerevisiae and Deinococcus radiodurans. Advantages of the approach include the high confidence of protein identification, its broad proteome coverage, high sensitivity, and the capability for stableisotope labeling methods for precise relative protein abundance measurements. Abbreviations : LC, liquid chromatography; FTICR, Fourier transform ion cyclotron resonance; AMT, accurate mass tag; PMT, potential mass tag; MMA, mass measurement accuracy; MS, mass spectrometry; MS/MS, tandem mass spectrometry; ppm, parts per million.« less

  10. Accelerating Spectrum Sharing Technologies

    SciTech Connect (OSTI)

    Juan D. Deaton; Lynda L. Brighton; Rangam Subramanian; Hussein Moradi; Jose Loera

    2013-09-01

    Spectrum sharing potentially holds the promise of solving the emerging spectrum crisis. However, technology innovators face the conundrum of developing spectrum sharing technologies without the ability to experiment and test with real incumbent systems. Interference with operational incumbents can prevent critical services, and the cost of deploying and operating an incumbent system can be prohibitive. Thus, the lack of incumbent systems and frequency authorization for technology incubation and demonstration has stymied spectrum sharing research. To this end, industry, academia, and regulators all require a test facility for validating hypotheses and demonstrating functionality without affecting operational incumbent systems. This article proposes a four-phase program supported by our spectrum accountability architecture. We propose that our comprehensive experimentation and testing approach for technology incubation and demonstration will accelerate the development of spectrum sharing technologies.

  11. HIGH ENERGY PARTICLE ACCELERATOR

    DOE Patents [OSTI]

    Courant, E.D.; Livingston, M.S.; Snyder, H.S.

    1959-04-14

    An improved apparatus is presented for focusing charged particles in an accelerator. In essence, the invention includes means for establishing a magnetic field in discrete sectors along the path of moving charged particles, the magnetic field varying in each sector in accordance with the relation. B = B/ sub 0/ STAln (r-r/sub 0/)/r/sub 0/!, where B/sub 0/ is the value of the magnetic field at the equilibrium orbit of radius r/sub 0/ of the path of the particles, B equals the magnetic field at the radius r of the chamber and n equals the magnetic field gradient index, the polarity of n being abruptly reversed a plurality of times as the particles travel along their arcuate path. With this arrangement, the particles are alternately converged towards the axis of their equillbrium orbit and diverged therefrom in successive sectors with a resultant focusing effect.

  12. Cast dielectric composite linear accelerator

    DOE Patents [OSTI]

    Sanders, David M. (Livermore, CA); Sampayan, Stephen (Manteca, CA); Slenes, Kirk (Albuquerque, NM); Stoller, H. M. (Albuquerque, NM)

    2009-11-10

    A linear accelerator having cast dielectric composite layers integrally formed with conductor electrodes in a solventless fabrication process, with the cast dielectric composite preferably having a nanoparticle filler in an organic polymer such as a thermosetting resin. By incorporating this cast dielectric composite the dielectric constant of critical insulating layers of the transmission lines of the accelerator are increased while simultaneously maintaining high dielectric strengths for the accelerator.

  13. Ideum awarded Venture Acceleration Funds

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ideum awarded Venture Acceleration Funds Motion recognition software business receives Venture Acceleration Funds LANS Venture Acceleration Fund (VAF) award enabled Ideum to develop motion recognition software for international release. April 3, 2012 Jim Spadaccini, owner of Ideum a software development company in Corrales Jim Spadaccini (R) has tapped into the Lab's economic development programs: VAF, NMSBA, Market Intelligence. Ideum, his Corrales, New Mexico based business, creates

  14. Improving Alpha Spectrometry Energy Resolution by Ion Implantation with ICP-MS

    SciTech Connect (OSTI)

    Dion, Michael P.; Liezers, Martin; Farmer, Orville T.; Miller, Brian W.; Morley, Shannon M.; Barinaga, Charles J.; Eiden, Gregory C.

    2015-01-01

    We report results of a novel technique using an Inductively Coupled Plasma Mass Spectrometer (ICP-MS) as a method of source preparation for alpha spectrometry. This method produced thin, contaminant free 241Am samples which yielded extraordinary energy resolution which appear to be at the lower limit of the detection technology used in this research.

  15. Time-of-flight heavy ion backscattering spectrometry

    SciTech Connect (OSTI)

    Knapp, J.A.; Banks, J.C.; Doyle, B.L.

    1993-08-01

    A new time-of-flight (TOF) ion detection system for Heavy Ion Backscattering Spectrometry (HIBS) is described. Examples are also given of the use of the system for measuring low-level contamination on Si wafers. Currently, the TOF-HBIS system has a sensitivity of 1 {times} 10{sup 9}/cm{sup 2} for the heaviest of surface impurity atoms and a mass resolution capable of separating Fe from Cu. The sensitivity is expected to improve by an additional order of magnitude on a industrial TOF-HIBS system being constructed for SEMATECH.

  16. Accelerator R&D

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Accelerator R&D Accelerator R&D Investigating the field of high energy physics through experiments that strengthen our fundamental understanding of matter, energy, space, and time. Get Expertise Rajan Gupta (505) 667-7664 Email Bruce Carlsten (505) 667-5657 Email Accelerator R&D R&D model Figure 1: Conceptual drawing of a superconducting radio-frequency accelerator with a PBG coupler cell. The ultimate goal of this project is to experimentally demonstrate the applicability of

  17. Compact accelerator for medical therapy

    DOE Patents [OSTI]

    Caporaso, George J.; Chen, Yu-Jiuan; Hawkins, Steven A.; Sampayan, Stephen E.; Paul, Arthur C.

    2010-05-04

    A compact accelerator system having an integrated particle generator-linear accelerator with a compact, small-scale construction capable of producing an energetic (.about.70-250 MeV) proton beam or other nuclei and transporting the beam direction to a medical therapy patient without the need for bending magnets or other hardware often required for remote beam transport. The integrated particle generator-accelerator is actuable as a unitary body on a support structure to enable scanning of a particle beam by direction actuation of the particle generator-accelerator.

  18. Accelerate Energy Productivity 2030 Launch

    Broader source: Energy.gov [DOE]

    Today, the Department of Energy kicked off Accelerate Energy Productivity 2030. This initiative supports President Obama’s goal to double our energy productivity by 2030.

  19. High field gradient particle accelerator

    DOE Patents [OSTI]

    Nation, John A.; Greenwald, Shlomo

    1989-01-01

    A high electric field gradient electron accelerator utilizing short duration, microwave radiation, and capable of operating at high field gradients for high energy physics applications or at reduced electric field gradients for high average current intermediate energy accelerator applications. Particles are accelerated in a smooth bore, periodic undulating waveguide, wherein the period is so selected that the particles slip an integral number of cycles of the r.f. wave every period of the structure. This phase step of the particles produces substantially continuous acceleration in a traveling wave without transverse magnetic or other guide means for the particle.

  20. High field gradient particle accelerator

    DOE Patents [OSTI]

    Nation, J.A.; Greenwald, S.

    1989-05-30

    A high electric field gradient electron accelerator utilizing short duration, microwave radiation, and capable of operating at high field gradients for high energy physics applications or at reduced electric field gradients for high average current intermediate energy accelerator applications is disclosed. Particles are accelerated in a smooth bore, periodic undulating waveguide, wherein the period is so selected that the particles slip an integral number of cycles of the r.f. wave every period of the structure. This phase step of the particles produces substantially continuous acceleration in a traveling wave without transverse magnetic or other guide means for the particle. 10 figs.

  1. 2012 Advanced Accelerator Concepts Workshop

    SciTech Connect (OSTI)

    Downer, Michael C.

    2015-03-23

    We report on the organization and outcome of the 2012 Advanced Accelerator Concepts Workshop, held in Austin, Texas in June 2012.

  2. Neutron spectrometry for UF6 enrichment verification in storage cylinders

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Mengesha, Wondwosen; Kiff, Scott D.

    2015-01-29

    Verification of declared UF6 enrichment and mass in storage cylinders is of great interest in nuclear material nonproliferation. Nondestructive assay (NDA) techniques are commonly used for safeguards inspections to ensure accountancy of declared nuclear materials. Common NDA techniques used include gamma-ray spectrometry and both passive and active neutron measurements. In the present study, neutron spectrometry was investigated for verification of UF6 enrichment in 30B storage cylinders based on an unattended and passive measurement approach. MCNP5 and Geant4 simulated neutron spectra, for selected UF6 enrichments and filling profiles, were used in the investigation. The simulated neutron spectra were analyzed using principalmore » component analysis (PCA). The PCA technique is a well-established technique and has a wide area of application including feature analysis, outlier detection, and gamma-ray spectral analysis. Results obtained demonstrate that neutron spectrometry supported by spectral feature analysis has potential for assaying UF6 enrichment in storage cylinders. The results from the present study also showed that difficulties associated with the UF6 filling profile and observed in other unattended passive neutron measurements can possibly be overcome using the approach presented.« less

  3. SBA Growth Accelerator Fund Competition

    Broader source: Energy.gov [DOE]

    The U.S. Small Business Administration (SBA) is accepting applications for the Growth Accelerator Fund Competition to identify the nation's innovative accelerators and similar organizations and award them cash prizes they may use to fund their operations costs and allow them to bring startup competitions to scale and new ideas to life.

  4. General purpose programmable accelerator board

    DOE Patents [OSTI]

    Robertson, Perry J.; Witzke, Edward L.

    2001-01-01

    A general purpose accelerator board and acceleration method comprising use of: one or more programmable logic devices; a plurality of memory blocks; bus interface for communicating data between the memory blocks and devices external to the board; and dynamic programming capabilities for providing logic to the programmable logic device to be executed on data in the memory blocks.

  5. RFQ accelerator tuning system

    DOE Patents [OSTI]

    Bolie, V.W.

    1990-07-03

    A cooling system is provided for maintaining a preselected operating temperature in a device, which may be an RFQ accelerator, having a variable heat removal requirement, by circulating a cooling fluid through a cooling system remote from the device. Internal sensors in the device enable an estimated error signal to be generated from parameters which are indicative of the heat removal requirement from the device. Sensors are provided at predetermined locations in the cooling system for outputting operational temperature signals. Analog and digital computers define a control signal functionally related to the temperature signals and the estimated error signal, where the control signal is defined effective to return the device to the preselected operating temperature in a stable manner. The cooling system includes a first heat sink responsive to a first portion of the control signal to remove heat from a major portion of the circulating fluid. A second heat sink is responsive to a second portion of the control signal to remove heat from a minor portion of the circulating fluid. The cooled major and minor portions of the circulating fluid are mixed in response to a mixing portion of the control signal, which is effective to proportion the major and minor portions of the circulating fluid to establish a mixed fluid temperature which is effective to define the preselected operating temperature for the remote device. In an RFQ environment the stable temperature control enables the resonant frequency of the device to be maintained at substantially a predetermined value during transient operations. 3 figs.

  6. RFQ accelerator tuning system

    DOE Patents [OSTI]

    Bolie, Victor W. (Albuquerque, NM)

    1990-01-01

    A cooling system is provided for maintaining a preselected operating temperature in a device, which may be an RFQ accelerator, having a variable heat removal requirement, by circulating a cooling fluid through a cooling system remote from the device. Internal sensors in the device enable an estimated error signal to be generated from parameters which are indicative of the heat removal requirement from the device. Sensors are provided at predetermined locations in the cooling system for outputting operational temperature signals. Analog and digital computers define a control signal functionally related to the temperature signals and the estimated error signal, where the control signal is defined effective to return the device to the preselected operating temperature in a stable manner. The cooling system includes a first heat sink responsive to a first portion of the control signal to remove heat from a major portion of the circulating fluid. A second heat sink is responsive to a second portion of the control signal to remove heat from a minor portion of the circulating fluid. The cooled major and minor portions of the circulating fluid are mixed in response to a mixing portion of the control signal, which is effective to proportion the major and minor portions of the circulating fluid to establish a mixed fluid temperature which is effective to define the preselected operating temperature for the remote device. In an RFQ environment the stable temperature control enables the resonant frequency of the device to be maintained at substantially a predetermined value during transient operations.

  7. Electron beam accelerator with magnetic pulse compression and accelerator switching

    DOE Patents [OSTI]

    Birx, Daniel L. (Brentwood, CA); Reginato, Louis L. (Orinda, CA)

    1988-01-01

    An electron beam accelerator comprising an electron beam generator-injector to produce a focused beam of .gtoreq.0.1 MeV energy electrons; a plurality of substantially identical, aligned accelerator modules to sequentially receive and increase the kinetic energies of the beam electrons by about 0.1-1 MeV per module. Each accelerator module includes a pulse-forming network that delivers a voltage pulse to the module of substantially .gtoreq.0.1-1 MeV maximum energy over a time duration of .ltoreq.1 .mu.sec.

  8. Electron beam accelerator with magnetic pulse compression and accelerator switching

    DOE Patents [OSTI]

    Birx, D.L.; Reginato, L.L.

    1984-03-22

    An electron beam accelerator is described comprising an electron beam generator-injector to produce a focused beam of greater than or equal to .1 MeV energy electrons; a plurality of substantially identical, aligned accelerator modules to sequentially receive and increase the kinetic energies of the beam electron by about .1-1 MeV per module. Each accelerator module includes a pulse-forming network that delivers a voltage pulse to the module of substantially .1-1 MeV maximum energy over a time duration of less than or equal to 1 ..mu..sec.

  9. Electron beam accelerator with magnetic pulse compression and accelerator switching

    DOE Patents [OSTI]

    Birx, Daniel L. (Brentwood, CA); Reginato, Louis L. (Orinda, CA)

    1987-01-01

    An electron beam accelerator comprising an electron beam generator-injector to produce a focused beam of .gtoreq.0.1 MeV energy electrons; a plurality of substantially identical, aligned accelerator modules to sequentially receive and increase the kinetic energies of the beam electrons by about 0.1-1 MeV per module. Each accelerator module includes a pulse-forming network that delivers a voltage pulse to the module of substantially 0.1-1 MeV maximum energy over a time duration of .ltoreq.1 .mu.sec.

  10. Fermilab | Illinois Accelerator Research Center | Fermilab Core

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Capabilities Core Capabilities photo Core capabilities Areas of Expertise Accelerator Science Beam dynamics and theory Design of linear and circular accelerators Simulation and Modeling Phase-space manipulation Energy Deposition Accelerator Operation Operation and commissioning of large, complex accelerator systems Accelerator Technology (design, fabrication, test) Particle sources Superconducting RF cavities and Cryomodules Conventional magnets Pulsed magnets and kickers Superconducting

  11. Extending Penning trap mass measurements with SHIPTRAP to the heaviest elements

    SciTech Connect (OSTI)

    Block, M.; Ackermann, D.; Herfurth, F.; Hofmann, S.; Blaum, K.; Droese, C.; Marx, G.; Schweikhard, L.; Duellmann, Ch. E.; Eibach, M.; Eliseev, S.; Haettner, E.; Plass, W. R.; Scheidenberger, C.; Hessberger, F. P.; Ramirez, E. Minaya; Nesterenko, D.; and others

    2013-03-19

    Penning-trap mass spectrometry of radionuclides provides accurate mass values and absolute binding energies. Such mass measurements are sensitive indicators of the nuclear structure evolution far away from stability. Recently, direct mass measurements have been extended to the heavy elements nobelium (Z=102) and lawrencium (Z=103) with the Penning-trap mass spectrometer SHIPTRAP. The results probe nuclear shell effects at N=152. New developments will pave the way to access even heavier nuclides.

  12. Quark Masses

    SciTech Connect (OSTI)

    Gasser, Juerg

    2005-10-26

    In my talk, I reviewed some basic aspects of quark masses: what do they mean, how can they be determined, what is our present knowledge on them. The talk was addressed to non specialists in the field, and so is this write up.

  13. Accelerated cleanup risk reduction

    SciTech Connect (OSTI)

    Knapp, R.B.; Aines, R.M.; Blake, R.G.; Copeland, A.B.; Newmark, R.L.; Tompson, A.F.B.

    1998-02-01

    There is no proven technology for remediating contaminant plume source regions in a heterogeneous subsurface. This project is an interdisciplinary effort to develop the requisite new technologies so that will be rapidly accepted by the remediation community. Our technology focus is hydrous pyrolysis/oxidation (HPO) which is a novel in situ thermal technique. We have expanded this core technology to leverage the action of steam injection and place an in situ microbial filter downstream to intercept and destroy the accelerated movement of contaminated groundwater. Most contaminant plume source regions, including the chlorinated solvent plume at LLNL, are in subsurface media characterized by a wide range in hydraulic conductivity. At LLNL, the main conduits for contaminant transport are buried stream channels composed of gravels and sands; these have a hydraulic conductivity in the range of 10{sup -1} to 10{sup -2} cm/s. Clay and silt units with a hydraulic conductivity of 10{sup -1} to 10{sup -6} cm/s bound these buried channels; these are barriers to groundwater movement and contain the highest contaminant concentrations in the source region. New remediation technologies are required because the current ones preferentially access the high conductivity units. HPO is an innovative process for the in situ destruction of contaminants in the entire subsurface. It operates by the injection of steam. We have demonstrated in laboratory experiments that many contaminants rapidly oxidize to harmless compounds at temperatures easily achieved by injecting steam, provided sufficient dissolved oxygen is present. One important challenge in a heterogeneous source region is getting heat, contaminants, and an oxidizing agent in the same place at the same time. We have used the NUFT computer program to simulate the cyclic injection of steam into a contaminated aquifer for design of a field demonstration. We used an 8 hour, steam/oxygen injection cycle followed by a 56 hour relaxation period in which the well was `capped`. Our results show the formation of an inclined gas phase during injection and a fast collapse of the steam zone within an hour of terminating steam injection. The majority of destruction occurs during the collapse phase, when contaminant laden water is drawn back towards the well. Little to no noncondensible gasses are created in this process, removing any possibility of sparging processes interfering with contaminant destruction. Our models suggest that the thermal region should be as hot and as large as possible. To have HPO accepted, we need to demonstrate the in situ destruction of contaminants. This requires the ability to inexpensively sample at depth and under high temperatures. We proved the ability to implies monitoring points at depths exceeding 150 feet in highly heterogeneous soils by use of cone penetrometry. In addition, an extractive system has been developed for sampling fluids and measuring their chemistry under the range of extreme conditions expected. We conducted a collaborative field test of HPO at a Superfund site in southern California where the contaminant is mainly creosote and pentachlorophenol. Field results confirm the destruction of contaminants by HPO, validate our field design from simulations, demonstrate that accurate field measurements of the critical fluid parameters can be obtained using existing monitoring wells (and minimal capital cost) and yield reliable cost estimates for future commercial application. We also tested the in situ microbial filter technology as a means to intercept and destroy the accelerated flow of contaminants caused by the injection of steam. A series of laboratory and field tests revealed that the selected bacterial species effectively degrades trichloroethene in LLNL Groundwater and under LLNL site conditions. In addition, it was demonstrated that the bacteria effectively attach to the LLNL subsurface media. An in-well treatability study indicated that the bacteria initially degrade greater than 99% of the contaminant, to concentrations less than regulatory limit

  14. Microelectromechanical dual-mass resonator structure

    DOE Patents [OSTI]

    Dyck, Christopher W. (Cedar Crest, NM); Allen, James J. (Albuquerque, NM); Huber, Robert J. (Bountiful, UT)

    2002-01-01

    A dual-mass microelectromechanical (MEM) resonator structure is disclosed in which a first mass is suspended above a substrate and driven to move along a linear or curved path by a parallel-plate electrostatic actuator. A second mass, which is also suspended and coupled to the first mass by a plurality of springs is driven by motion of the first mass. Various modes of operation of the MEM structure are possible, including resonant and antiresonant modes, and a contacting mode. In each mode of operation, the motion induced in the second mass can be in the range of several microns up to more than 50 .mu.m while the first mass has a much smaller displacement on the order of one micron or less. The MEM structure has applications for forming microsensors that detect strain, acceleration, rotation or movement.

  15. PowerPoint-Präsentation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Accelerator Mass Spectrometry (AMS) at ATLAS Walter Kutschera Vienna Environmental Research Accelerator (VERA) Fakultt fr Physik, Universitt Wien, Austria ATLAS 25 th...

  16. Cascaded target normal sheath acceleration

    SciTech Connect (OSTI)

    Wang, W. P.; Shen, B. F.; Zhang, X. M.; Wang, X. F.; Xu, J. C.; Zhao, X. Y.; Yu, Y. H.; Yi, L. Q.; Shi, Y.; Zhang, L. G.; Xu, T. J.; Xu, Z. Z.

    2013-11-15

    A cascaded target normal sheath acceleration (TNSA) scheme is proposed to simultaneously increase energy and improve energy spread of a laser-produced mono-energetic proton beam. An optimum condition that uses the maximum sheath field to accelerate the center of the proton beam is theoretically found and verified by two-dimensional particle-in-cell simulations. An initial 10 MeV proton beam is accelerated to 21 MeV with energy spread decreased from 5% to 2% under the optimum condition during the process of the cascaded TNSA. The scheme opens a way to scale proton energy lineally with laser energy.

  17. Ultrasensitive search for long-lived superheavy nuclides in the mass range A=288 to A=300 in natural Pt, Pb, and Bi

    SciTech Connect (OSTI)

    Dellinger, F.; Forstner, O.; Golser, R.; Priller, A.; Steier, P.; Wallner, A.; Winkler, G.; Kutschera, W.

    2011-06-15

    Theoretical models of superheavy elements (SHEs) predict a region of increased stability around the proton and neutron shell closures of Z = 114 and N = 184. Therefore a sensitive search for nuclides in the mass range from A = 288 to A = 300 was performed in natural platinum, lead, and bismuth, covering long-lived isotopes of Eka-Pt (Ds, Z = 110), Eka-Pb (Z = 114), and Eka-Bi (Z = 115). Measurements with accelerator mass spectrometry (AMS) at the Vienna Environmental Research Accelerator (VERA) established upper limits for these SHE isotopes in Pt, Pb, and Bi with abundances of <2x10{sup -15}, <5x10{sup -14}, and <5x10{sup -13}, respectively. These results complement earlier searches for SHEs with AMS at VERA in natural thorium and gold, which now amounts to a total number of 37 SHE nuclides having been explored with AMS. In none of our measurements was evidence found for the existence of SHEs in nature at the reported sensitivity level. Even though a few events were observed in the window for {sup 293}Eka-Bi, a particularly strong pileup background did not allow a definite SHE isotope identification. The present result sets limits on nuclides around the center of the island of stability, essentially ruling out the existence of SHE nuclides with half-lives longer than {approx}150 million years.

  18. Fermilab | Illinois Accelerator Research Center | More Information

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    More Information General Office of Partnerships and Technology Transfer Illinois Department of Commerce and Economic Opportunity Department of Energy Advanced Superconductor Test Accelerator Accelerator Applications 4th Edition, "Accelerators and Beams, Tools of Discovery and Innovation"

  19. Fermilab | Science | Particle Accelerators | Advanced Superconducting Test

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Accelerator Fermilab Accelerator Science and Technology Facility photo The Fermilab Accelerator Science and Technology (FAST) Facility is America's only test bed for cutting-edge particle beams and for accelerator research aimed at intensity frontier proton accelerators. FAST will also be unique in the United States as a particle beam research facility based on superconducting radio-frequency technology, on which nearly all proposed future accelerators in the world are based. The science

  20. Ideum awarded Venture Acceleration Funds

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ideum accelerates international software launch as a result of VAF award and business coaching Jim Spadaccini was first drawn to New Mexico by the beauty of Chaco Canyon. "I was...

  1. Sequentially pulsed traveling wave accelerator

    DOE Patents [OSTI]

    Caporaso, George J. (Livermore, CA); Nelson, Scott D. (Patterson, CA); Poole, Brian R. (Tracy, CA)

    2009-08-18

    A sequentially pulsed traveling wave compact accelerator having two or more pulse forming lines each with a switch for producing a short acceleration pulse along a short length of a beam tube, and a trigger mechanism for sequentially triggering the switches so that a traveling axial electric field is produced along the beam tube in synchronism with an axially traversing pulsed beam of charged particles to serially impart energy to the particle beam.

  2. Accelerator physics and modeling: Proceedings

    SciTech Connect (OSTI)

    Parsa, Z.

    1991-12-31

    This report contains papers on the following topics: Physics of high brightness beams; radio frequency beam conditioner for fast-wave free-electron generators of coherent radiation; wake-field and space-charge effects on high brightness beams. Calculations and measured results for BNL-ATF; non-linear orbit theory and accelerator design; general problems of modeling for accelerators; development and application of dispersive soft ferrite models for time-domain simulation; and bunch lengthening in the SLC damping rings.

  3. Accelerator physics and modeling: Proceedings

    SciTech Connect (OSTI)

    Parsa, Z.

    1991-01-01

    This report contains papers on the following topics: Physics of high brightness beams; radio frequency beam conditioner for fast-wave free-electron generators of coherent radiation; wake-field and space-charge effects on high brightness beams. Calculations and measured results for BNL-ATF; non-linear orbit theory and accelerator design; general problems of modeling for accelerators; development and application of dispersive soft ferrite models for time-domain simulation; and bunch lengthening in the SLC damping rings.

  4. Accelerating CHP Deployment, United States Energy Association...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Accelerating CHP Deployment, United States Energy Association (USEA), August 2011 Accelerating CHP Deployment, United States Energy Association (USEA), August 2011 The United ...

  5. ASTA at Fermilab: Accelerator Physics and Accelerator Education Programs at the Modern Accelerator R&D Users Facility for HEP and Accelerator Applications.

    SciTech Connect (OSTI)

    Shiltsev, V.; Piot, P.

    2013-09-01

    We present the current and planned beam physics research program and accelerator education program at Advanced Superconducting Test Accelerator (ASTA) at Fermilab.

  6. Berkeley Lab Particle Accelerator Sets World Record

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Traditional particle accelerators, like the Large Hadron Collider at CERN, which is 17 miles ... Particle Accelerators NERSC Resources Used: Edison, Hopper DOE Program ...

  7. SLAC National Accelerator Laboratory Technology Marketing Summaries...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SLAC National Accelerator Laboratory Technology Marketing Summaries Here you'll find marketing summaries for technologies available for licensing from the SLAC National Accelerator...

  8. High-Intensity Proton Accelerator

    SciTech Connect (OSTI)

    Jay L. Hirshfield

    2011-12-27

    Analysis is presented for an eight-cavity proton cyclotron accelerator that could have advantages as compared with other accelerators because of its potentially high acceleration gradient. The high gradient is possible since protons orbit in a sequence of TE111 rotating mode cavities of equally diminishing frequencies with path lengths during acceleration that greatly exceed the cavity lengths. As the cavities operate at sequential harmonics of a basic repetition frequency, phase synchronism can be maintained over a relatively wide injection phase window without undue beam emittance growth. It is shown that use of radial vanes can allow cavity designs with significantly smaller radii, as compared with simple cylindrical cavities. Preliminary beam transport studies show that acceptable extraction and focusing of a proton beam after cyclic motion in this accelerator should be possible. Progress is also reported on design and tests of a four-cavity electron counterpart accelerator for experiments to study effects on beam quality arising from variations injection phase window width. This device is powered by four 500-MW pulsed amplifiers at 1500, 1800, 2100, and 2400 MHz that provide phase synchronous outputs, since they are driven from a with harmonics derived from a phase-locked 300 MHz source.

  9. Collective accelerator using field-reversed plasma rings

    SciTech Connect (OSTI)

    Hartman, C.W.

    1981-09-19

    This note discusses the possibility of magnetically accelerating the plasma rings. At low-to-moderate ring kinetic energy, application to heating, fueling, and efficient current drive of conventional fusion reactors appears possible. At high ring kinetic energy, applications to inertial-confinement fusion through pellet heating and to transuranic element synthesis appear possible. The rings may be considered to be a self-linking flux bundle having net helicity. From an accelerator point of view, the rings represent collective particle entities held together by magnetic forces and may be viewed as macroparticles or micropellets having large magnetic moment per unit mass. Because of the relatively long lifetime and resiliency of the rings, it appears possible to accelerate to multimegajoule kinetic energy over reasonable distances and to focus the rings to centimeter-size dimensions.

  10. SuperB Progress Report for Accelerator

    SciTech Connect (OSTI)

    Biagini, M.E.; Boni, R.; Boscolo, M.; Buonomo, B.; Demma, T.; Drago, A.; Esposito, M.; Guiducci, S.; Mazzitelli, G.; Pellegrino, L.; Preger, M.A.; Raimondi, P.; Ricci, R.; Rotundo, U.; Sanelli, C.; Serio, M.; Stella, A.; Tomassini, S.; Zobov, M.; Bertsche, K.; Brachman, A.; /SLAC /Novosibirsk, IYF /INFN, Pisa /Pisa U. /Orsay, LAL /Annecy, LAPP /LPSC, Grenoble /IRFU, SPP, Saclay /DESY /Cockroft Inst. Accel. Sci. Tech. /U. Liverpool /CERN

    2012-02-14

    This report details the progress made in by the SuperB Project in the area of the Collider since the publication of the SuperB Conceptual Design Report in 2007 and the Proceedings of SuperB Workshop VI in Valencia in 2008. With this document we propose a new electron positron colliding beam accelerator to be built in Italy to study flavor physics in the B-meson system at an energy of 10 GeV in the center-of-mass. This facility is called a high luminosity B-factory with a project name 'SuperB'. This project builds on a long history of successful e+e- colliders built around the world, as illustrated in Figure 1.1. The key advances in the design of this accelerator come from recent successes at the DAFNE collider at INFN in Frascati, Italy, at PEP-II at SLAC in California, USA, and at KEKB at KEK in Tsukuba Japan, and from new concepts in beam manipulation at the interaction region (IP) called 'crab waist'. This new collider comprises of two colliding beam rings, one at 4.2 GeV and one at 6.7 GeV, a common interaction region, a new injection system at full beam energies, and one of the two beams longitudinally polarized at the IP. Most of the new accelerator techniques needed for this collider have been achieved at other recently completed accelerators including the new PETRA-3 light source at DESY in Hamburg (Germany) and the upgraded DAFNE collider at the INFN laboratory at Frascati (Italy), or during design studies of CLIC or the International Linear Collider (ILC). The project is to be designed and constructed by a worldwide collaboration of accelerator and engineering staff along with ties to industry. To save significant construction costs, many components from the PEP-II collider at SLAC will be recycled and used in this new accelerator. The interaction region will be designed in collaboration with the particle physics detector to guarantee successful mutual use. The accelerator collaboration will consist of several groups at present universities and national laboratories. In Italy these may include INFN Frascati and the University of Pisa, in the United States SLAC, LBNL, BNL and several universities, in France IN2P3, LAPP, and Grenoble, in Russia BINP, in Poland Krakow University, and in the UK the Cockcroft Institute. The construction time for this collider is a total of about four years. The new tunnel can be bored in about a year. The new accelerator components can be built and installed in about 4 years. The shipping of components from PEP-II at SLAC to Italy will take about a year. A new linac and damping ring complex for the injector for the rings can be built in about three years. The commissioning of this new accelerator will take about a year including the new electron and positron sources, new linac, new damping ring, new beam transport lines, two new collider rings and the Interaction Region. The new particle physics detector can be commissioned simultaneously with the accelerator. Once beam collisions start for particle physics, the luminosity will increase with time, likely reaching full design specifications after about two to three years of operation. After construction, the operation of the collider will be the responsibility of the Italian INFN governmental agency. The intent is to run this accelerator about ten months each year with about one month for accelerator turn-on and nine months for colliding beams. The collider will need to operate for about 10 years to provide the required 50 ab{sup -1} requested by the detector collaboration. Both beams as anticipated in this collider will have properties that are excellent for use as sources for synchrotron radiation (SR). The expected photon properties are comparable to those of PETRA-3 or NSLS-II. The beam lines and user facilities needed to carry out this SR program are being investigated.

  11. Accelerator and electrodynamics capability review

    SciTech Connect (OSTI)

    Jones, Kevin W

    2010-01-01

    Los Alamos National Laboratory (LANL) uses capability reviews to assess the science, technology and engineering (STE) quality and institutional integration and to advise Laboratory Management on the current and future health of the STE. Capability reviews address the STE integration that LANL uses to meet mission requirements. The Capability Review Committees serve a dual role of providing assessment of the Laboratory's technical contributions and integration towards its missions and providing advice to Laboratory Management. The assessments and advice are documented in reports prepared by the Capability Review Committees that are delivered to the Director and to the Principal Associate Director for Science, Technology and Engineering (PADSTE). Laboratory Management will use this report for STE assessment and planning. LANL has defined fifteen STE capabilities. Electrodynamics and Accelerators is one of the seven STE capabilities that LANL Management (Director, PADSTE, technical Associate Directors) has identified for review in Fiscal Year (FY) 2010. Accelerators and electrodynamics at LANL comprise a blend of large-scale facilities and innovative small-scale research with a growing focus on national security applications. This review is organized into five topical areas: (1) Free Electron Lasers; (2) Linear Accelerator Science and Technology; (3) Advanced Electromagnetics; (4) Next Generation Accelerator Concepts; and (5) National Security Accelerator Applications. The focus is on innovative technology with an emphasis on applications relevant to Laboratory mission. The role of Laboratory Directed Research and Development (LDRD) in support of accelerators/electrodynamics will be discussed. The review provides an opportunity for interaction with early career staff. Program sponsors and customers will provide their input on the value of the accelerator and electrodynamics capability to the Laboratory mission.

  12. Compact hydrogen/helium isotope mass spectrometer

    DOE Patents [OSTI]

    Funsten, Herbert O. (Los Alamos, NM); McComas, David J. (Los Alamos, NM); Scime, Earl E. (Morgantown, WV)

    1996-01-01

    The compact hydrogen and helium isotope mass spectrometer of the present invention combines low mass-resolution ion mass spectrometry and beam-foil interaction technology to unambiguously detect and quantify deuterium (D), tritium (T), hydrogen molecule (H.sub.2, HD, D.sub.2, HT, DT, and T.sub.2), .sup.3 He, and .sup.4 He concentrations and concentration variations. The spectrometer provides real-time, high sensitivity, and high accuracy measurements. Currently, no fieldable D or molecular speciation detectors exist. Furthermore, the present spectrometer has a significant advantage over traditional T detectors: no confusion of the measurements by other beta-emitters, and complete separation of atomic and molecular species of equivalent atomic mass (e.g., HD and .sup.3 He).

  13. Accelerated expansion of the universe à la the Stueckelberg mechanism

    SciTech Connect (OSTI)

    Akarsu, Özgür; Ar?k, Metin; Kat?rc?, Nihan; Kavuk, Mehmet E-mail: metin.arik@boun.edu.tr E-mail: mehmet.kavuk@boun.edu.tr

    2014-07-01

    We investigate a cosmological model in which the Stueckelberg fields are non-minimally coupled to the scalar curvature in a gauge invariant manner. We present not only a solution that can be considered in the context of the late time acceleration of the universe but also a solution compatible with the inflationary cosmology. Distinct behaviors of the scalar and vector fields together with the real valued mass gained by the Stueckelberg mechanism lead the universe to go through the two different accelerated expansion phases with a decelerated expansion phase between them. On the other hand, in the solutions we present, if the mass is null then the universe is either static or exhibits a simple power law expansion due to the vector field potential.

  14. Accelerator Technology Division annual report, FY 1989

    SciTech Connect (OSTI)

    Not Available

    1990-06-01

    This paper discusses: accelerator physics and special projects; experiments and injectors; magnetic optics and beam diagnostics; accelerator design and engineering; radio-frequency technology; accelerator theory and simulation; free-electron laser technology; accelerator controls and automation; and high power microwave sources and effects.

  15. Ultra-high vacuum photoelectron linear accelerator

    DOE Patents [OSTI]

    Yu, David U.L.; Luo, Yan

    2013-07-16

    An rf linear accelerator for producing an electron beam. The outer wall of the rf cavity of said linear accelerator being perforated to allow gas inside said rf cavity to flow to a pressure chamber surrounding said rf cavity and having means of ultra high vacuum pumping of the cathode of said rf linear accelerator. Said rf linear accelerator is used to accelerate polarized or unpolarized electrons produced by a photocathode, or to accelerate thermally heated electrons produced by a thermionic cathode, or to accelerate rf heated field emission electrons produced by a field emission cathode.

  16. Accelerator on a Chip | Department of Energy

    Energy Savers [EERE]

    Accelerator on a Chip Accelerator on a Chip February 4, 2016 - 5:24pm Addthis Scientists at SLAC are attempting to build a particle accelerator the size of a shoe box. | Video courtesy of SLAC. Andrew Gordon SLAC National Accelerator Laboratory Could tiny chips no bigger than grains of rice do the job of a huge particle accelerator? At full potential, a series of these "accelerators on a chip" could boost electrons to the same high energies achieved in SLAC National Accelerator

  17. Virtual gap dielectric wall accelerator

    DOE Patents [OSTI]

    Caporaso, George James; Chen, Yu-Jiuan; Nelson, Scott; Sullivan, Jim; Hawkins, Steven A

    2013-11-05

    A virtual, moving accelerating gap is formed along an insulating tube in a dielectric wall accelerator (DWA) by locally controlling the conductivity of the tube. Localized voltage concentration is thus achieved by sequential activation of a variable resistive tube or stalk down the axis of an inductive voltage adder, producing a "virtual" traveling wave along the tube. The tube conductivity can be controlled at a desired location, which can be moved at a desired rate, by light illumination, or by photoconductive switches, or by other means. As a result, an impressed voltage along the tube appears predominantly over a local region, the virtual gap. By making the length of the tube large in comparison to the virtual gap length, the effective gain of the accelerator can be made very large.

  18. Laser ablation molecular isotopic spectrometry of carbon isotopes

    SciTech Connect (OSTI)

    Bol'shakov, Alexander A.; Jain, Jinesh; Russo, Richard E.; McIntyre, Dustin; Mao, Xianglei

    2015-08-28

    Quantitative determination of carbon isotopes using Laser Ablation Molecular Isotopic Spectrometry (LAMIS) is described. Optical emission of diatomic molecules CN and C2 is used in these measurements. Two quantification approaches are presented:empirical calibration of spectra using a set of reference standards and numerical fitting of a simulated spectrum to the experimental one. Formation mechanisms of C2 and CN in laser ablation plasma are briefly reviewed to provide insights for implementation of LAMIS measurements. A simulated spectrum of the 12C2 Swan system was synthesized using four constituents within 473.5–476.5 nm. Simulation included three branches of 12C2 (1-0), branches R(0-0) and R(1-1), and branch P(9-8) of 12C2. Spectral positions of the tail lines in R(0-0) and R(1-1) were experimentally measured, since they were not accurately known before. The Swan band (1-0) of the isotopologue 13C12C was also simulated. Fitting to the experimental spectrumyielded the ratio 13C/12C = 1.08% in a good agreement with measurements by isotope ratio mass spectrometry. LAMIS promises to be useful in coal, oil and shale exploration, carbon sequestration monitoring, and agronomy studies

  19. Electron Cloud Effects in Accelerators

    SciTech Connect (OSTI)

    Furman, M.A.

    2012-11-30

    Abstract We present a brief summary of various aspects of the electron-cloud effect (ECE) in accelerators. For further details, the reader is encouraged to refer to the proceedings of many prior workshops, either dedicated to EC or with significant EC contents, including the entire ?ECLOUD? series [1?22]. In addition, the proceedings of the various flavors of Particle Accelerator Conferences [23] contain a large number of EC-related publications. The ICFA Beam Dynamics Newsletter series [24] contains one dedicated issue, and several occasional articles, on EC. An extensive reference database is the LHC website on EC [25].

  20. Muon Acceleration R and D

    SciTech Connect (OSTI)

    Torun, Yagmur

    2009-12-17

    An intense muon source can be built in stages to support a uniquely broad program in high energy physics. Starting with a low-energy cooled muon beam, extraordinarily precise lepton flavor violation experiments are possible. Upgrading the facility with acceleration and a muon storage ring, one can build a Neutrino Factory that would allow a neutrino mixing physics program with unprecedented precision. Adding further acceleration and a collider ring, an energy-frontier muon collider can explore electroweak symmetry breaking and open a window to new physics.

  1. Ideum awarded Venture Acceleration Funds

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ideum awarded Venture Acceleration Funds April 3, 2012 Ideum accelerates international software launch as a result of VAF award and business coaching Jim Spadaccini was first drawn to New Mexico by the beauty of Chaco Canyon. "I was working on a project with NASA and the National Park Service at the time, and I just kept coming back," he says. "I didn't know then that New Mexico would also be a great place to start a business." Fast-forward six years, and Spadaccini's

  2. Market Research Survey of Commercial Off-the-Shelf Mass Spectrometers for In-Field Analysis. FY 15 Update

    SciTech Connect (OSTI)

    Yoshida, Thomas M.; Leibman, Christopher Patrick; Stark, Peter C.

    2015-11-12

    This report is an update of the 2013 Market Research Survey1-3 of field-deployable commercial off-the-shelf (COTS) mass spectrometry instruments for safeguards application.

  3. Time-of-flight detector for heavy ion backscattering spectrometry

    SciTech Connect (OSTI)

    Knapp, J.A.; Banks, J.C.; Doyle, B.L.

    1994-04-01

    This report describes the results of a two-year laboratory directed research and development project to explore advanced concepts in Heavy Ion Backscattering Spectrometry (HIBS), undertaken with the goal of extending the sensitivity of this relatively new technique to levels unattainable by any other existing trace element surface analysis. Improvements in sensitivity are required for the application of HIBS to contamination control in the microelectronics industry. Tools with sensitivity approaching 10{sup 8} atoms/cm{sup 2} are expected to be essential for enabling advanced IC production by the year 2000. During the project the authors developed a new analysis chamber with channeling goniometer and a prototype time-of-flight detector with a demonstrated sensitivity of {approximately} 5 {times} 10{sup 8} atoms/cm{sup 2} for Au on Si and {approximately} 5 {times} 10{sup 10} for Fe, and sufficient mass resolution to separate contributions from Fe and Cu.

  4. ACCELERATION PHYSICS CODE WEB REPOSITORY.

    SciTech Connect (OSTI)

    WEI, J.

    2006-06-26

    In the framework of the CARE HHH European Network, we have developed a web-based dynamic accelerator-physics code repository. We describe the design, structure and contents of this repository, illustrate its usage, and discuss our future plans, with emphasis on code benchmarking.

  5. Accelerator Physics Code Web Repository

    SciTech Connect (OSTI)

    Zimmermann, F.; Basset, R.; Bellodi, G.; Benedetto, E.; Dorda, U.; Giovannozzi, M.; Papaphilippou, Y.; Pieloni, T.; Ruggiero, F.; Rumolo, G.; Schmidt, F.; Todesco, E.; Zotter, B.W.; Payet, J.; Bartolini, R.; Farvacque, L.; Sen, T.; Chin, Y.H.; Ohmi, K.; Oide, K.; Furman, M.; /LBL, Berkeley /Oak Ridge /Pohang Accelerator Lab. /SLAC /TRIUMF /Tech-X, Boulder /UC, San Diego /Darmstadt, GSI /Rutherford /Brookhaven

    2006-10-24

    In the framework of the CARE HHH European Network, we have developed a web-based dynamic accelerator-physics code repository. We describe the design, structure and contents of this repository, illustrate its usage, and discuss our future plans, with emphasis on code benchmarking.

  6. Petawatt pulsed-power accelerator

    DOE Patents [OSTI]

    Stygar, William A. (Albuquerque, NM); Cuneo, Michael E. (Albuquerque, NM); Headley, Daniel I. (Albuquerque, NM); Ives, Harry C. (Albuquerque, NM); Ives, legal representative; Berry Cottrell (Albuquerque, NM); Leeper, Ramon J. (Albuquerque, NM); Mazarakis, Michael G. (Albuquerque, NM); Olson, Craig L. (Albuquerque, NM); Porter, John L. (Sandia Park, NM); Wagoner; Tim C. (Albuquerque, NM)

    2010-03-16

    A petawatt pulsed-power accelerator can be driven by various types of electrical-pulse generators, including conventional Marx generators and linear-transformer drivers. The pulsed-power accelerator can be configured to drive an electrical load from one- or two-sides. Various types of loads can be driven; for example, the accelerator can be used to drive a high-current z-pinch load. When driven by slow-pulse generators (e.g., conventional Marx generators), the accelerator comprises an oil section comprising at least one pulse-generator level having a plurality of pulse generators; a water section comprising a pulse-forming circuit for each pulse generator and a level of monolithic triplate radial-transmission-line impedance transformers, that have variable impedance profiles, for each pulse-generator level; and a vacuum section comprising triplate magnetically insulated transmission lines that feed an electrical load. When driven by LTD generators or other fast-pulse generators, the need for the pulse-forming circuits in the water section can be eliminated.

  7. High Performance Outdoor Lighting Accelerator

    Broader source: Energy.gov [DOE]

    Hosted by the U.S. Department of Energy (DOE)’s Weatherization and Intergovernmental Programs Office (WIPO), this webinar covered the expansion of the Better Buildings platform to include the newest initiative for the public sector: the High Performance Outdoor Lighting Accelerator (HPOLA).

  8. Combined distance-of-flight and time-of-flight mass spectrometer

    DOE Patents [OSTI]

    Enke, Christie G; Ray, Steven J; Graham, Alexander W; Hieftje, Gary M; Barinaga, Charles J; Koppenaal, David W

    2014-02-11

    A combined distance-of-flight mass spectrometry (DOFMS) and time-of-flight mass spectrometry (TOFMS) instrument includes an ion source configured to produce ions having varying mass-to-charge ratios, a first detector configured to determine when each of the ions travels a predetermined distance, a second detector configured to determine how far each of the ions travels in a predetermined time, and a detector extraction region operable to direct portions of the ions either to the first detector or to the second detector.

  9. High-precision Penning trap mass measurements for tests of the Standard Model

    SciTech Connect (OSTI)

    Blaum, Klaus; Eliseev, Sergey; Nagy, Szilard

    2010-08-04

    With the nowadays achievable accuracy in Penning trap mass spectrometry on short-lived exotic nuclides as well as stable atoms, precision fundamental tests can be performed, among them a test of the Standard Model, in particular with regard to the weak interaction, the CPT symmetry conservation, and the unitarity of the Cabibbo-Kobayashi-Maskawa quark mixing matrix. In addition, accurate mass values of specific nuclides are important for neutrino physics. The presently best tests of the Standard Model with high-precision Penning trap mass spectrometry will be reviewed.

  10. Plasma Wakefield Acceleration and FACET - Facilities for Accelerator Science and Experimental Test Beams at SLAC

    ScienceCinema (OSTI)

    Andrei Seryi

    2010-01-08

    Plasma wakefield acceleration is one of the most promising approaches to advancing accelerator technology. This approach offers a potential 1,000-fold or more increase in acceleration over a given distance, compared to existing accelerators.  FACET, enabled by the Recovery Act funds, will study plasma acceleration, using short, intense pulses of electrons and positrons. In this lecture, the physics of plasma acceleration and features of FACET will be presented.  

  11. Effect of electromagnetic pulse transverse inhomogeneity on ion acceleration by radiation pressure

    SciTech Connect (OSTI)

    Lezhnin, K. V.; Kamenets, F. F.; Beskin, V. S.; Kando, M.; Esirkepov, T. Zh.; Bulanov, S. V.

    2015-03-15

    During ion acceleration by radiation pressure, a transverse inhomogeneity of an electromagnetic pulse leads to an off-axis displacement of the irradiated target, limiting the achievable ion energy. This effect is analytically described within the framework of a thin foil target model and with particle-in-cell simulations showing that the maximum energy of the accelerated ions decreases as the displacement from the axis of the target's initial position increases. The results obtained can be applied to the optimization of ion acceleration by the laser radiation pressure with mass-limited targets.

  12. Weighing galaxy clusters with gas. II. On the origin of hydrostatic mass bias in ?CDM galaxy clusters

    SciTech Connect (OSTI)

    Nelson, Kaylea; Nagai, Daisuke; Yu, Liang; Lau, Erwin T.; Rudd, Douglas H.

    2014-02-20

    The use of galaxy clusters as cosmological probes hinges on our ability to measure their masses accurately and with high precision. Hydrostatic mass is one of the most common methods for estimating the masses of individual galaxy clusters, which suffer from biases due to departures from hydrostatic equilibrium. Using a large, mass-limited sample of massive galaxy clusters from a high-resolution hydrodynamical cosmological simulation, in this work we show that in addition to turbulent and bulk gas velocities, acceleration of gas introduces biases in the hydrostatic mass estimate of galaxy clusters. In unrelaxed clusters, the acceleration bias is comparable to the bias due to non-thermal pressure associated with merger-induced turbulent and bulk gas motions. In relaxed clusters, the mean mass bias due to acceleration is small (? 3%), but the scatter in the mass bias can be reduced by accounting for gas acceleration. Additionally, this acceleration bias is greater in the outskirts of higher redshift clusters where mergers are more frequent and clusters are accreting more rapidly. Since gas acceleration cannot be observed directly, it introduces an irreducible bias for hydrostatic mass estimates. This acceleration bias places limits on how well we can recover cluster masses from future X-ray and microwave observations. We discuss implications for cluster mass estimates based on X-ray, Sunyaev-Zel'dovich effect, and gravitational lensing observations and their impact on cluster cosmology.

  13. The US Muon Accelerator Program

    SciTech Connect (OSTI)

    Torun, Y.; Kirk, H.; Bross, A.; Geer, Steve; Shiltsev, Vladimir; Zisman, M.; /LBL, Berkeley

    2010-05-01

    An accelerator complex that can produce ultra-intense beams of muons presents many opportunities to explore new physics. A facility of this type is unique in that, in a relatively straightforward way, it can present a physics program that can be staged and thus move forward incrementally, addressing exciting new physics at each step. At the request of the US Department of Energy's Office of High Energy Physics, the Neutrino Factory and Muon Collider Collaboration (NFMCC) and the Fermilab Muon Collider Task Force (MCTF) have recently submitted a proposal to create a Muon Accelerator Program that will have, as a primary goal, to deliver a Design Feasibility Study for an energy-frontier Muon Collider by the end of a 7 year R&D program. This paper presents a description of a Muon Collider facility and gives an overview of the proposal.

  14. Linear induction accelerator parameter options

    SciTech Connect (OSTI)

    Birx, D.L.; Caporaso, G.J.; Reginato, L.L.

    1986-04-21

    The principal undertaking of the Beam Research Program over the past decade has been the investigation of propagating intense self-focused beams. Recently, the major activity of the program has shifted toward the investigation of converting high quality electron beams directly to laser radiation. During the early years of the program, accelerator development was directed toward the generation of very high current (>10 kA), high energy beams (>50 MeV). In its new mission, the program has shifted the emphasis toward the production of lower current beams (>3 kA) with high brightness (>10/sup 6/ A/(rad-cm)/sup 2/) at very high average power levels. In efforts to produce these intense beams, the state of the art of linear induction accelerators (LIA) has been advanced to the point of satisfying not only the current requirements but also future national needs.

  15. Accelerator on a Chip: How It Works

    ScienceCinema (OSTI)

    None

    2014-07-16

    In an advance that could dramatically shrink particle accelerators for science and medicine, researchers used a laser to accelerate electrons at a rate 10 times higher than conventional technology in a nanostructured glass chip smaller than a grain of rice.

  16. Accelerator on a Chip: How It Works

    SciTech Connect (OSTI)

    2014-06-30

    In an advance that could dramatically shrink particle accelerators for science and medicine, researchers used a laser to accelerate electrons at a rate 10 times higher than conventional technology in a nanostructured glass chip smaller than a grain of rice.

  17. Symposium report on frontier applications of accelerators

    SciTech Connect (OSTI)

    Parsa, Z.

    1993-09-28

    This report contains viewgraph material on the following topics: Electron-Positron Linear Colliders; Unconventional Colliders; Prospects for UVFEL; Accelerator Based Intense Spallation; Neutron Sources; and B Physics at Hadron Accelerators with RHIC as an Example.

  18. Muon acceleration in cosmic-ray sources

    SciTech Connect (OSTI)

    Klein, Spencer R.; Mikkelsen, Rune E. [Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States); Becker Tjus, Julia [Fakultät für Physik and Astronomie, Theoretische Physik I, Ruhr-Universität Bochum, D-44780 Bochum (Germany)

    2013-12-20

    Many models of ultra-high energy cosmic-ray production involve acceleration in linear accelerators located in gamma-ray bursts, magnetars, or other sources. These transient sources have short lifetimes, which necessitate very high accelerating gradients, up to 10{sup 13} keV cm{sup –1}. At gradients above 1.6 keV cm{sup –1}, muons produced by hadronic interactions undergo significant acceleration before they decay. This muon acceleration hardens the neutrino energy spectrum and greatly increases the high-energy neutrino flux. Using the IceCube high-energy diffuse neutrino flux limits, we set two-dimensional limits on the source opacity and matter density, as a function of accelerating gradient. These limits put strong constraints on different models of particle acceleration, particularly those based on plasma wake-field acceleration, and limit models for sources like gamma-ray bursts and magnetars.

  19. SPEAR3 Accelerator | Stanford Synchrotron Radiation Lightsource

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SPEAR3 Accelerator SPEAR3 SSRL utilizes x-rays produced by its accelerator, the Stanford Positron Electron Asymmetric Ring (SPEAR3). Based on a 2004 upgrade funded by the...

  20. NREL: Technology Deployment - Technology Acceleration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Technology Acceleration NREL offers technology-specific assistance to federal and private industry to help address market barriers to sustainable energy technologies. Learn more about NREL's work in the following areas: Biopower and Waste-to-Energy Biopower and Waste-to-Energy Buildings Buildings Fuels, Vehicles, & Transportation Fuels, Vehicles, and Transportation Microgrid Design Microgrid Design Solar Solar Wind Wind Contact Us For more information on NREL's market transformation work,

  1. Accelerated Aging of Roofing Surfaces

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Accelerated aging of roofing surfaces Hugo Destaillats, Ph.D. Lawrence Berkeley National Laboratory HDestaillats@LBL.gov (510) 486-5897 http://HeatIsland.LBL.gov April 4, 2013 Development of Advanced Building Envelope Surface Materials & Integration of Artificial Soiling and Weathering in a Commercial Weatherometer New York Times, 30 July 2009 2010 2012 Challenge: speed the development of high performance building envelope materials that resist soiling, maintain high solar reflectance, and

  2. Energy Data Accelerator Stakeholder Engagement

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Data Accelerator Stakeholder Engagement 2015 Building Technologies Office Peer Review Erica Cochran PhD, EricaC@andrew.cmu.edu CBEI/Carnegie Mellon University Project Summary Timeline: Start date: April, 2014 Key Partners: Planned end date: April, 2016 Key Milestones: * Webinar on Stakeholder Engagement strategies: April, 2014 * Checklist for stakeholder engagement: September, 2014 * Case Studies outlining 2 successful city-utility partnerships: April, 2015 Budget: * Total DOE $ to date:

  3. Better Buildings Energy Data Accelerator

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Data Accelerator *NEW PROJECT* 2014 Building Technologies Office Peer Review Monisha Shah, monisha.shah@nrel.gov Kristin Field, kristin.field@nrel.gov National Renewable Energy Laboratory Project Summary *NEW PROJECT* Timeline: Start date: June 2013 (official launch: December 2013) Planned end date: December 2015 Key Milestones 1. Recruitment of 20 Partner-pairs 2. White House Launch and design of the program - Dec 2013 3. Partners convene local stakeholders - May 2014 4. 20 Partner-pairs

  4. accelerators | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    accelerators | National Nuclear Security Administration Facebook Twitter Youtube Flickr RSS People Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Countering Nuclear Terrorism About Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Library Bios Congressional Testimony Fact Sheets Newsletters Press Releases Photo Gallery Jobs Apply for Our Jobs Our Jobs Working at NNSA Blog

  5. Cryogenic supply for accelerators and experiments at FAIR

    SciTech Connect (OSTI)

    Kauschke, M.; Xiang, Y.; Schroeder, C. H.; Streicher, B.; Kollmus, H.

    2014-01-29

    In the coming years the new international accelerator facility FAIR (Facility for Antiproton and Ion Research), one of the largest research projects worldwide, will be built at GSI. In the final construction FAIR consists of synchrotrons and storage rings with up to 1,100 meters in circumference, two linear accelerators and about 3.5 kilometers beam transfer lines. The existing GSI accelerators serve as pre-accelerators. Partly the new machines will consist of superconducting magnets and therefore require a reliable supply with liquid helium. As the requirements for the magnets is depending on the machine and have a high variety, the cooling system is different for each machine; two phase cooling, forced flow cooling and bath cooling respectively. In addition the cold mass of the individual magnets varies between less than 1t up to 80t and some magnets will cause a dynamic heat load due to ramping that is higher than the static loads. The full cryogenic system will be operated above atmospheric pressure. The refrigeration and liquefaction power will be provided by two main cryogenic plants of 8 and 25 kW at 4K and two smaller plants next to the experiments.

  6. The story of the Tevatron accelerators: Accelerator science and technology breakthroughs, achievements and lessons

    SciTech Connect (OSTI)

    Shiltsev, V.; /Fermilab

    2012-01-01

    For almost a quarter of a century, the Tevatron proton-antiproton collider was the centerpiece of the world's high energy physics program - since it began operation in December of 1985, until it was overtaken by LHC in 2011. The aim of this unique scientific instrument was to explore the elementary particle physics reactions with center of mass collision energies of up to 1.96 TeV. The initial design luminosity of the Tevatron was 10{sup 30} cm{sup -2} s{sup -1}, however as a result of two decades of upgrades, the accelerator has been able to deliver 430 times higher luminosities to each of two high luminosity experiments, CDF and D0. The Tevatron has been shut off since September 30, 2011. The collider was arguably one of the most complex research instruments ever to reach the operation stage and is widely recognized for many technological breakthroughs and numerous physics discoveries. In this paper, we briefly present the history of the Tevatron, major advances in accelerator physics, technology implemented during the long quest for better and better performance, and the lessons learned from our experience.

  7. Compensation Techniques in Accelerator Physics

    SciTech Connect (OSTI)

    Hisham Kamal Sayed

    2011-05-31

    Accelerator physics is one of the most diverse multidisciplinary fields of physics, wherein the dynamics of particle beams is studied. It takes more than the understanding of basic electromagnetic interactions to be able to predict the beam dynamics, and to be able to develop new techniques to produce, maintain, and deliver high quality beams for different applications. In this work, some basic theory regarding particle beam dynamics in accelerators will be presented. This basic theory, along with applying state of the art techniques in beam dynamics will be used in this dissertation to study and solve accelerator physics problems. Two problems involving compensation are studied in the context of the MEIC (Medium Energy Electron Ion Collider) project at Jefferson Laboratory. Several chromaticity (the energy dependence of the particle tune) compensation methods are evaluated numerically and deployed in a figure eight ring designed for the electrons in the collider. Furthermore, transverse coupling optics have been developed to compensate the coupling introduced by the spin rotators in the MEIC electron ring design.

  8. Plasma Wakefield Acceleration: How it Works

    SciTech Connect (OSTI)

    2014-11-05

    This animation explains how electrons can be efficiently accelerated to high energy using wakes created in a plasma.

  9. Materials Classification & Accelerated Property Predictions using...

    Office of Scientific and Technical Information (OSTI)

    Title: Materials Classification & Accelerated Property Predictions using Machine Learning ... Country of Publication: United States Language: English Subject: Materials Science(36) ...

  10. Mechanical Design Engineering, MDE, Accelerator Operations and...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AOT-MDE's primary responsibilities include supporting accelerator operations, maintenance, and performance improvement projects; developing leadership roles in projects...

  11. IARC - Illinois Accelerator Research Center | Pilot Program

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fermi National Accelerator Laboratory and Argonne National Laboratory present Accelerator Stewardship Test Facility Pilot Program Use accelerator technology development and testing facilities. Speak with experts in the field. photo collage Accelerator technologies are vital to broad sectors of the U.S. economy, including medicine, industry, defense and security, energy and environment. With this pilot program, the DOE Office of Science National Laboratories are opening their doors to potential

  12. Comments on backreaction and cosmic acceleration

    SciTech Connect (OSTI)

    Kolb, Edward W.; Matarrese, Sabinio; Riotto, Antonion; /CERN

    2005-11-01

    In this brief WEB note we comment on recent papers related to our paper ''On Acceleration Without Dark Energy''.

  13. How Particle Accelerators Work | Department of Energy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Particle Accelerators Work How Particle Accelerators Work June 18, 2014 - 4:11pm Addthis Infographic by <a href="/node/379579">Sarah Gerrity</a>, Energy Department. Infographic by Sarah Gerrity, Energy Department. Ben Dotson Ben Dotson Former Project Coordinator for Digital Reform, Office of Public Affairs What are the key facts? A particle accelerator is a machine that accelerates elementary particles, such as electrons or protons, to very high energies. Whether it's

  14. ICFA: International Committee for Future Accelerators

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ICFA - International Committee for Future Accelerators Membership Secretary What, Why, Who is ICFA? ICFA Meetings Panels Recent Linear Collider Activities Statements Related Reports ICFA: International Committee for Future Accelerators ICFA, the International Committee for Future Accelerators, was created to facilitate international collaboration in the construction and use of accelerators for high energy physics. It was created in 1976 by the International Union of Pure and Applied Physics. Its

  15. Accelerating Investments in the Geothermal Sector, Indonesia...

    Open Energy Info (EERE)

    Accelerating Investments in the Geothermal Sector, Indonesia (Presentation) Author Paul Brophy Conference World Geothermal Energy Summit; Jakarta, Indonesia; 20120706...

  16. Evaluation of Longitudinal Variabler in Relativistic Accelerators

    Energy Science and Technology Software Center (OSTI)

    1995-07-13

    ELVIRA is an encoding of an analytical formula to the calculation of longitudinal dynamics variable evolution during an accelerator ramp.

  17. Terahertz-driven linear electron acceleration

    SciTech Connect (OSTI)

    Nanni, Emilio A.; Huang, Wenqian R.; Hong, Kyung-Han; Ravi, Koustuban; Fallahi, Arya; Moriena, Gustavo; Dwayne Miller, R. J.; Kärtner, Franz X.

    2015-10-06

    The cost, size and availability of electron accelerators are dominated by the achievable accelerating gradient. Conventional high-brightness radio-frequency accelerating structures operate with 30–50 MeVm-1 gradients. Electron accelerators driven with optical or infrared sources have demonstrated accelerating gradients orders of magnitude above that achievable with conventional radio-frequency structures. However, laser-driven wakefield accelerators require intense femtosecond sources and direct laser-driven accelerators suffer from low bunch charge, sub-micron tolerances and sub-femtosecond timing requirements due to the short wavelength of operation. Here we demonstrate linear acceleration of electrons with keV energy gain using optically generated terahertz pulses. Terahertz-driven accelerating structures enable high-gradient electron/proton accelerators with simple accelerating structures, high repetition rates and significant charge per bunch. As a result, these ultra-compact terahertz accelerators with extremely short electron bunches hold great potential to have a transformative impact for free electron lasers, linear colliders, ultrafast electron diffraction, X-ray science and medical therapy with X-rays and electron beams.

  18. Voltage regulation in linear induction accelerators

    DOE Patents [OSTI]

    Parsons, William M. (Santa Fe, NM)

    1992-01-01

    Improvement in voltage regulation in a Linear Induction Accelerator wherein a varistor, such as a metal oxide varistor, is placed in parallel with the beam accelerating cavity and the magnetic core. The non-linear properties of the varistor result in a more stable voltage across the beam accelerating cavity than with a conventional compensating resistance.

  19. Voltage regulation in linear induction accelerators

    DOE Patents [OSTI]

    Parsons, W.M.

    1992-12-29

    Improvement in voltage regulation in a linear induction accelerator wherein a varistor, such as a metal oxide varistor, is placed in parallel with the beam accelerating cavity and the magnetic core is disclosed. The non-linear properties of the varistor result in a more stable voltage across the beam accelerating cavity than with a conventional compensating resistance. 4 figs.

  20. Accelerate Energy Productivity 2030 fact sheet | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Accelerate Energy Productivity 2030 fact sheet Accelerate Energy Productivity 2030 fact sheet PDF icon Accelerate Energy Productivity 2030 Fact Sheet- Updated More Documents &...

  1. Accelerator Technology Division annual report, FY 1991

    SciTech Connect (OSTI)

    Not Available

    1992-04-01

    This report discusses the following programs: The Ground Test Accelerator Program; APLE Free-Electron Laser Program; Accelerator Transmutation of Waste; JAERI, OMEGA Project, and Intense Neutron Source for Materials Testing; Advanced Free-Electron Laser Initiative; Superconducting Super Collider; The High-Power Microwave Program; {Phi} Factory Collaboration; Neutral Particle Beam Power System Highlights; Accelerator Physics and Special Projects; Magnetic Optics and Beam Diagnostics; Accelerator Design and Engineering; Radio-Frequency Technology; Free-Electron Laser Technology; Accelerator Controls and Automation; Very High-Power Microwave Sources and Effects; and GTA Installation, Commissioning, and Operations.

  2. Accelerated learning approaches for maintenance training

    SciTech Connect (OSTI)

    Erickson, E.J.

    1991-01-01

    As a training tool, Accelerated Learning techniques have been in use since 1956. Trainers from a variety of applications and disciplines have found success in using Accelerated Learning approaches, such as training aids, positive affirmations, memory aids, room arrangement, color patterns, and music. Some have thought that maintenance training and Accelerated Learning have nothing in common. Recent training applications by industry and education of Accelerated Learning are proving very successful by several standards. This paper cites available resource examples and challenges maintenance trainers to adopt new ideas and concepts to accelerate learning in all training setting. 7 refs.

  3. FFAG ACCELERATOR PROTON DRIVER FOR NEUTRINO FACTORY.

    SciTech Connect (OSTI)

    RUGGIERO, A.

    2005-06-21

    This paper is the summary of a conceptual study of a Proton Driver for Neutrino Factory based on the use of a Fixed-Field Alternating-Gradient (FFAG) Accelerator. The required proton energy range for an optimum neutrino production is 5 to 12 GeV. This can be accomplished with a group of three concentric rings each with 807 m circumference [1]. FFAG Accelerators [2] have the capability to accelerate charged particles over a large momentum range ({+-}30-50%) and the feature of constant bending and focusing fields. Particles can be accelerated very fast at the rate given by the accelerating field of RF cavities placed in proper locations between magnets. The performance of FFAG accelerators is to be placed between that of Super-Conducting Linear Accelerators (SCL), with which they share the fast acceleration rate, and Rapid-Cycling Synchrotrons (RCS), as they allow the beam to re-circulate over fewer revolutions. Brookhaven National Laboratory is involved in the study of feasibility of FFAG Accelerators to accelerate intense beams of protons in the GeV energy range for a variety of applications the most important of which is the Upgrade of the Alternating Gradient Synchrotron (AGS) with a new FFAG injector [3] accelerating from 400 MeV to 1.5 GeV. The ring would be housed in the AGS tunnel and has henceforth a circumference of 807 m.

  4. Terahertz-driven linear electron acceleration

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Nanni, Emilio A.; Huang, Wenqian R.; Hong, Kyung-Han; Ravi, Koustuban; Fallahi, Arya; Moriena, Gustavo; Dwayne Miller, R. J.; Kärtner, Franz X.

    2015-10-06

    The cost, size and availability of electron accelerators are dominated by the achievable accelerating gradient. Conventional high-brightness radio-frequency accelerating structures operate with 30–50 MeVm-1 gradients. Electron accelerators driven with optical or infrared sources have demonstrated accelerating gradients orders of magnitude above that achievable with conventional radio-frequency structures. However, laser-driven wakefield accelerators require intense femtosecond sources and direct laser-driven accelerators suffer from low bunch charge, sub-micron tolerances and sub-femtosecond timing requirements due to the short wavelength of operation. Here we demonstrate linear acceleration of electrons with keV energy gain using optically generated terahertz pulses. Terahertz-driven accelerating structures enable high-gradient electron/proton acceleratorsmore » with simple accelerating structures, high repetition rates and significant charge per bunch. As a result, these ultra-compact terahertz accelerators with extremely short electron bunches hold great potential to have a transformative impact for free electron lasers, linear colliders, ultrafast electron diffraction, X-ray science and medical therapy with X-rays and electron beams.« less

  5. Deuterium accelerator experiments for APT.

    SciTech Connect (OSTI)

    Causey, Rion A. (Sandia National Laboratories, Livermore, CA); Hertz, Kristin L. (Sandia National Laboratories, Livermore, CA); Cowgill, Donald F. (Sandia National Laboratories, Livermore, CA)

    2005-08-01

    Sandia National Laboratories in California initiated an experimental program to determine whether tritium retention in the tube walls and permeation through the tubes into the surrounding coolant water would be a problem for the Accelerator Production of Tritium (APT), and to find ways to mitigate the problem, if it existed. Significant holdup in the tube walls would limit the ability of APT to meet its production goals, and high levels of permeation would require a costly cleanup system for the cooling water. To simulate tritium implantation, a 200 keV accelerator was used to implant deuterium into Al 6061-T and SS3 16L samples at temperatures and particle fluxes appropriate for APT, for times varying between one week and five months. The implanted samples were characterized to determine the deuterium retention and Permeation. During the implantation, the D(d,p)T nuclear reaction was used to monitor the build-up of deuterium in the implant region of the samples. These experiments increased in sophistication, from mono-energetic deuteron implants to multi-energetic deuteron and proton implants, to more accurately reproduce the conditions expected in APT. Micron-thick copper, nickel, and anodized aluminum coatings were applied to the front surface of the samples (inside of the APT walls) in an attempt to lower retention and permeation. The reduction in both retention and permeation produced by the nickel coatings, and the ability to apply them to the inside of the APT tubes, indicate that both nickel-coated Al 6061-T6 and nickel-coated SS3 16L tubes would be effective for use in APT. The results of this work were submitted to the Accelerator Production of Tritium project in document number TPO-E29-Z-TNS-X-00050, APT-MP-01-17.

  6. Community Petascale Project for Accelerator Science and Simulation: Advancing Computational Science for Future Accelerators and Accelerator Technologies

    SciTech Connect (OSTI)

    Spentzouris, P.; /Fermilab; Cary, J.; /Tech-X, Boulder; McInnes, L.C.; /Argonne; Mori, W.; /UCLA; Ng, C.; /SLAC; Ng, E.; Ryne, R.; /LBL, Berkeley

    2011-11-14

    The design and performance optimization of particle accelerators are essential for the success of the DOE scientific program in the next decade. Particle accelerators are very complex systems whose accurate description involves a large number of degrees of freedom and requires the inclusion of many physics processes. Building on the success of the SciDAC-1 Accelerator Science and Technology project, the SciDAC-2 Community Petascale Project for Accelerator Science and Simulation (ComPASS) is developing a comprehensive set of interoperable components for beam dynamics, electromagnetics, electron cooling, and laser/plasma acceleration modelling. ComPASS is providing accelerator scientists the tools required to enable the necessary accelerator simulation paradigm shift from high-fidelity single physics process modeling (covered under SciDAC1) to high-fidelity multiphysics modeling. Our computational frameworks have been used to model the behavior of a large number of accelerators and accelerator R&D experiments, assisting both their design and performance optimization. As parallel computational applications, the ComPASS codes have been shown to make effective use of thousands of processors. ComPASS is in the first year of executing its plan to develop the next-generation HPC accelerator modeling tools. ComPASS aims to develop an integrated simulation environment that will utilize existing and new accelerator physics modules with petascale capabilities, by employing modern computing and solver technologies. The ComPASS vision is to deliver to accelerator scientists a virtual accelerator and virtual prototyping modeling environment, with the necessary multiphysics, multiscale capabilities. The plan for this development includes delivering accelerator modeling applications appropriate for each stage of the ComPASS software evolution. Such applications are already being used to address challenging problems in accelerator design and optimization. The ComPASS organization for software development and applications accounts for the natural domain areas (beam dynamics, electromagnetics, and advanced acceleration), and all areas depend on the enabling technologies activities, such as solvers and component technology, to deliver the desired performance and integrated simulation environment. The ComPASS applications focus on computationally challenging problems important for design or performance optimization to all major HEP, NP, and BES accelerator facilities. With the cost and complexity of particle accelerators rising, the use of computation to optimize their designs and find improved operating regimes becomes essential, potentially leading to significant cost savings with modest investment.

  7. Radiological Training for Accelerator Facilities

    Energy Savers [EERE]

    8-2002 May 2002 Change Notice No 1. with Reaffirmation January 2007 DOE HANDBOOK RADIOLOGICAL TRAINING FOR ACCELERATOR FACILITIES U.S. Department of Energy AREA TRNG Washington, D.C. 20585 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. TS This document has been reproduced from the best available copy. Available to DOE and DOE contractors from ES&H Technical Information Services, U.S. Department of Energy, (800) 473-4375, fax: (301) 903-9823. Available to

  8. Ultra High Mass Range Mass Spectrometer System

    DOE Patents [OSTI]

    Reilly, Peter T. A. [Knoxville, TN

    2005-12-06

    Applicant's present invention comprises mass spectrometer systems that operate in a mass range from 1 to 10.sup.16 DA. The mass spectrometer system comprising an inlet system comprising an aerodynamic lens system, a reverse jet being a gas flux generated in an annulus moving in a reverse direction and a multipole ion guide; a digital ion trap; and a thermal vaporization/ionization detector system. Applicant's present invention further comprises a quadrupole mass spectrometer system comprising an inlet system having a quadrupole mass filter and a thermal vaporization/ionization detector system. Applicant's present invention further comprises an inlet system for use with a mass spectrometer system, a method for slowing energetic particles using an inlet system. Applicant's present invention also comprises a detector device and a method for detecting high mass charged particles.

  9. 1997 SSRL Accelerator Physics Schedule

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SSRL Accelerator Physics Schedule Proposal Deadline Schedule Announcement Experimental Period Duration Mon, Nov 11, '96 17:00 Tue, Nov 12, '96 13:00 Tue, Nov 19, '96 15:00-Wed, Nov 20, '96 02:00 11 hrs Mon, Dec 02, '96 17:00 Tue, Dec 03, '96 13:00 Mon, Dec 09, '96 06:00-Wed, Dec 11, '96 02:00 44 hrs Mon, Jan 06, 17:00 Tue, Jan 07, 13:00 Mon, Jan 13, 18:00-Wed, Jan 15, 02:00 32 hrs Mon, Jan 20, 17:00 Tue, Jan 21, 13:00 Mon, Jan 27, 06:00-Wed, Jan 29, 02:00 44 hrs Mon, Feb 03, 17:00 Tue, Feb 04,

  10. 1998 SSRL Accelerator Physics Schedule

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    8 SSRL Accelerator Physics Schedule Proposal Deadline Schedule Announcement Experimental Period Duration Tue, Nov 11, 17:00 Wed, Nov 12, '97 17:00 Mon, Nov 17, '97 18:00-Wed, Nov 19, '97 02:00 32 hrs Mon, Dec 01, '97 17:00 Tue, Dec 02, '97 13:00 Mon, Dec 08, '97 06:00-Wed, Dec 10, '97 02:00 44 hrs Mon, Jan 05, 17:00 Tue, Jan 06, 13:00 Mon, Jan 12, 18:00-Wed, Jan 14, 02:00 32 hrs Fri, Jan 16, 17:00 Tue, Jan 20, 13:00 Mon, Jan 26, 06:00-Wed, Jan 28, 02:00 44 hrs Mon, Feb 02, 17:00 Tue, Feb 03,

  11. 1999 SSRL Accelerator Physics Schedule

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SSRL Accelerator Physics Schedule Proposal Deadline Schedule Announcement Experimental Period Duration Mon, Nov 30, '98 17:00 Tue, Dec 01, '98 13:00 Mon, Dec 07, '98 06:00-Wed, Dec 09, '98 02:00 44 hrs Mon, Jan 04, 17:00 Tue, Jan 05, 13:00 Mon, Jan 11, 18:00-Wed, Jan 13, 02:00 32 hrs Fri, Jan 15, 17:00 Tue, Jan 19, 13:00 Mon, Jan 25, 06:00-Wed, Jan 27, 02:00 44 hrs Mon, Feb 01, 17:00 Tue, Feb 02, 13:00 Tue, Feb 09, 18:00-Thu, Feb 11, 02:00 32 hrs Tue, Feb 16, 17:00 Wed, Feb 17, 17:00 Mon, Feb

  12. 2000 SSRL Accelerator Physics Schedule

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SSRL Accelerator Physics Schedule Proposal Deadline Schedule Announcement Experimental Period Duration Mon, Nov 08, '99 17:00 Tue, Nov 09, '99 13:00 Mon, Nov 15, '99 18:00-Wed, Nov 17, '99 02:00 32 hrs Mon, Nov 29, '99 17:00 Tue, Nov 30, '99 13:00 Mon, Dec 06, '99 06:00-Wed, Dec 08, '99 02:00 44 hrs Mon, Jan 03, 17:00 Tue, Jan 04, 13:00 Mon, Jan 10, 18:00-Wed, Jan 12, 02:00 32 hrs Fri, Jan 14, 17:00 Tue, Jan 18, 13:00 Mon, Jan 24, 06:00-Wed, Jan 26, 02:00 44 hrs Mon, Feb 14, 17:00 Tue, Feb 15,

  13. 2001 SSRL Accelerator Physics Schedule

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SSRL Accelerator Physics Schedule Proposal Deadline Schedule Announcement Experimental Period Duration Mon, Nov 06, '00 17:00 Tue, Nov 07, '00 13:00 Mon, Nov 13, '00 18:00-Wed, Nov 15, '00 02:00 32 hrs Mon, Dec 04, '00 17:00 Tue, Dec 05, '00 13:00 Mon, Dec 11, '00 06:00-Wed, Dec 13, '00 02:00 44 hrs Mon, Jan 01, 17:00 Tue, Jan 02, 13:00 Mon, Jan 08, 18:00-Wed, Jan 10, 02:00 32 hrs Fri, Jan 12, 12:00 Tue, Jan 16, 13:00 Mon, Jan 22, 06:00-Wed, Jan 24, 02:00 44 hrs Mon, Jan 29, 17:00 Tue, Jan 30,

  14. 2002 SSRL Accelerator Physics Schedule

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SSRL Accelerator Physics Schedule Proposal Deadline Schedule Announcement Experimental Period Duration Mon, Nov 05, '01 17:00 Tue, Nov 06, '01 13:00 Mon, Nov 12, '01 18:00-Wed, Nov 14, '01 02:00 32 hrs Mon, Dec 03, '01 17:00 Tue, Dec 04, '01 13:00 Mon, Dec 10, '01 06:00-Wed, Dec 12, '01 02:00 44 hrs Mon, Dec 17, '01 09:00 Tue, Dec 18, '01 13:00 Mon, Jan 07, 18:00-Wed, Jan 9, 02:00 32 hrs Mon, Jan 14, 12:00 Tue, Jan 15, 13:00 Tue, Jan 22, 06:00-Thu, Jan 24, 02:00 44 hrs Mon, Jan 28, 17:00 Tue,

  15. 2003 SSRL Accelerator Physics Schedule

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SSRL Accelerator Physics Schedule Proposal Deadline Schedule Announcement Experimental Period Duration Mon, Dec 02, '02 17:00 Tue, Dec 03, '02 13:00 Mon, Dec 09, '02 18:00-Wed, Dec 11, '02 02:00 32 hrs Tue, Jan 07, 09:00 Tue, Jan 07, 13:00 Mon, Jan 13, 18:00-Wed, Jan 15, 02:00 32 hrs Mon, Feb 03, 17:00 Tue, Feb 04, 17:00 Mon, Feb 10, 18:00-Wed, Feb 12, 02:00 32 hrs Mon, Feb 24, 17:00 Tue, Feb 25, 13:00 Mon, Mar 03, 18:00-Wed, Mar 05, 02:00 32 hrs SLAC SSRL SSRL Last Updated: 25 February 2003

  16. Accelerator Technology Division progress report, FY 1993

    SciTech Connect (OSTI)

    Schriber, S.O.; Hardekopf, R.A.; Heighway, E.A.

    1993-12-31

    This report discusses the following topics: A Next-Generation Spallation-Neutron Source; Accelerator Performance Demonstration Facility; APEX Free-Electron Laser Project; The Ground Test Accelerator (GTA) Program; Intense Neutron Source for Materials Testing; Linac Physics and Special Projects; Magnetic Optics and Beam Diagnostics; Radio-Frequency Technology; Accelerator Controls and Automation; Very High-Power Microwave Sources and Effects; and GTA Installation, Commissioning, and Operation.

  17. Accelerating Offshore Wind Development | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Accelerating Offshore Wind Development Accelerating Offshore Wind Development Click on a project for more information. The Energy Department has selected seven projects that will accelerate the commercialization of innovative offshore wind technologies in the United States. Each project will receive up to $4 million from the Energy Department to complete the engineering, site evaluation, and planning phase of their project. Upon completion of this phase, the Energy Department will select the up

  18. 'Erratic' Lasers Pave Way for Tabletop Accelerators

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Lasers Pave Way for Tabletop Accelerators 'Erratic' Lasers Pave Way for Tabletop Accelerators Simulations at NERSC help researchers simplify design of mini particle accelerators June 9, 2014 Kate Green, KGreene@lbl.gov, 510-486-4404 laserplasmaaccelerator 3D map of the longitudinal wakefield generated by the incoherent combination of 208 low-energy laser beamlets. In the region behind the driver, the wakefield is regular. Image: Carlo Benedetti, Berkeley Lab Making a tabletop particle

  19. Fermilab | Illinois Accelerator Research Center | Contact IARC

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Contact IARC thumb IARC director SRF Program Director Robert Kephart Kephart@fnal.gov (630) 840-3135 As the Director of IARC my goal is to bridge the gap between breakthroughs in accelerator science and technology and solutions for society. IARC will allow our university and laboratory partners to leverage Fermilab's extensive accelerator infrastructure and expertise, resulting in new accelerator-based products and businesses in the United States. thumb IARC General Manager Charlie Cooper

  20. Kwok Ko SLAC National Accelerator Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Kwok Ko SLAC National Accelerator Laboratory Work supported by US DOE Offices of HEP, ASCR and BES under contract AC02-76SF00515. Large Scale Computing and Storage Requirements for High Energy Physics Rockville, MD, November 27-28, 2012 Present and Future Computing Requirements for Advanced Modeling for Particle Accelerator 1. Advanced Modeling for Particle Accelerators (AMPA) NERSC Repositories: m349 Principal Investigator: K. Ko Senior Investigators: SLAC - L. Ge, Z. Li, C. Ng, L. Xiao, FNAL -

  1. LANL announces Venture Acceleration Fund recipients

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    LANL announces Venture Acceleration Fund recipients LANL announces Venture Acceleration Fund recipients Ideum and OnQueue are the latest recipients of the awards from the Los Alamos National Security, LLC Venture Acceleration Fund. September 26, 2011 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and

  2. Seventhwave: Accelerate Performance | Department of Energy

    Energy Savers [EERE]

    Seventhwave: Accelerate Performance Seventhwave: Accelerate Performance Lead Performer: Seventhwave Partners: National Renewable Energy Laboratory, Institute for Sustainable Energy at Eastern Connecticut State DOE Total Funding: $1 million Cost Share: $1 million Project Term: August 1, 2015 - July 31, 2018 Funding Opportunity: Advancing Solutions to Improve the Energy Efficiency of U.S. Commercial Buildings (2015) PROJECT OBJECTIVE Accelerate Performance is designed to harness the energy savings

  3. Accelerate Energy Productivity 2030 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Initiatives » Accelerate Energy Productivity 2030 Accelerate Energy Productivity 2030 On September 16, 2015, the U.S. Department of Energy and its partners, the Council on Competitiveness and the Alliance to Save Energy, released Accelerate Energy Productivity 2030: A Strategic Roadmap for American Energy Innovation, Economic Growth, and Competitiveness (Roadmap). This effort supports the goal the President set in his 2013 State of the Union address to double energy productivity, measured by

  4. Induction accelerators and free-electron lasers at LLNL: Beam Research Program

    SciTech Connect (OSTI)

    Briggs, R.J.

    1989-02-15

    Linear induction accelerators have been developed to produce pulses of charged particles at voltages exceeding the capabilities of single-stage, diode-type accelerators and at currents too high rf accelerators. In principle, one can accelerate charged particles to arbitrarily high voltages using a multistage induction machine. The advent of magnetic pulse power systems makes sustained operation at high repetition rates practical, and high-average-power capability is very likely to open up many new applications of induction machines. In Part A of this paper, we survey the US induction linac technology, emphasizing electron machines. We also give a simplified description of how induction machines couple energy to the electron beam to illustrate many general issues that designers of high-brightness and high-average-power induction linacs must consider. We give an example of the application of induction accelerator technology to the relativistic klystron, a power source for high-gradient accelerators. In Part B we address the application of LIAs to free-electron lasers. The multikiloampere peak currents available from linear induction accelerators make high-gain, free-electron laser amplifier configurations feasible. High extraction efficiencies in a single mass of the electron beam are possible if the wiggler parameters are appropriately ''tapered'', as recently demonstrated at millimeter wavelengths on the 4-MeV ELF facility. Key issues involved in extending the technology to shorter wavelengths and higher average powers are described. Current FEL experiments at LLNL are discussed. 5 refs., 16 figs.

  5. Materials considerations in accelerator targets

    SciTech Connect (OSTI)

    Peacock, H.B. Jr.; Iyer, N.C.; Louthan, M.R. Jr.

    1994-08-01

    Future nuclear materials production and/or the burn-up of long lived radioisotopes may be accomplished through the capture of spallation produced neutrons in accelerators. Aluminum clad-lead and/or lead alloys has been proposed as a spallation target. Aluminum was the cladding choice because of the low neutron absorption cross section, fast radioactivity decay, high thermal conductivity, and excellent fabricability. Metallic lead and lead oxide powders were considered for the target core with the fabrication options being casting or powder metallurgy (PM). Scoping tests to evaluate gravity casting, squeeze casting, and casting and swaging processes showed that, based on fabricability and heat transfer considerations, squeeze casting was the preferred option for manufacture of targets with initial core cladding contact. Thousands of aluminum clad aluminum-lithium alloy core targets and control rods for tritium production have been fabricated by coextrusion processes and successfully irradiated in the SRS reactors. Tritium retention in, and release from the coextruded product was modeled from experimental and operational data. Newly produced tritium atoms were trapped by lithium atoms to form a lithium tritide. The effective tritium pressure required for trap or tritide stability was the equilibrium decomposition pressure of tritium over a lithium tritide-aluminum mixture. The temperature dependence of tritium release was determined by the permeability of the cladding to tritium and the local equilibrium at the trap sites. The model can be used to calculate tritium release from aluminum clad, aluminum-lithium alloy targets during postulated accelerator operational and accident conditions. This paper describes the manufacturing technologies evaluated and presents the model for tritium retention in aluminum clad, aluminum-lithium alloy tritium production targets.

  6. Report on accelerated corrosion studies.

    SciTech Connect (OSTI)

    Mowry, Curtis Dale; Glass, Sarah Jill; Sorensen, Neil Robert

    2011-03-01

    Sandia National Laboratories (SNL) conducted accelerated atmospheric corrosion testing for the U.S. Consumer Product Safety Commission (CPSC) to help further the understanding of the development of corrosion products on conductor materials in household electrical components exposed to environmental conditions representative of homes constructed with problem drywall. The conditions of the accelerated testing were chosen to produce corrosion product growth that would be consistent with long-term exposure to environments containing humidity and parts per billion (ppb) levels of hydrogen sulfide (H{sub 2}S) that are thought to have been the source of corrosion in electrical components from affected homes. This report documents the test set-up, monitoring of electrical performance of powered electrical components during the exposure, and the materials characterization conducted on wires, screws, and contact plates from selected electrical components. No degradation in electrical performance (measured via voltage drop) was measured during the course of the 8-week exposure, which was approximately equivalent to 40 years of exposure in a light industrial environment. Analyses show that corrosion products consisting of various phases of copper sulfide, copper sulfate, and copper oxide are found on exposed surfaces of the conductor materials including wires, screws, and contact plates. The morphology and the thickness of the corrosion products showed a range of character. In some of the copper wires that were observed, corrosion product had flaked or spalled off the surface, exposing fresh metal to the reaction with the contaminant gasses; however, there was no significant change in the wire cross-sectional area.

  7. Accelerating cleanup: Paths to closure

    SciTech Connect (OSTI)

    1998-06-01

    This report describes the status of Environmental Management`s (EM`s) cleanup program and a direction forward to complete achievement of the 2006 vision. Achieving the 2006 vision results in significant benefits related to accomplishing EM program objectives. As DOE sites accelerate cleanup activities, risks to public health, the environment, and worker safety and health are all reduced. Finding more efficient ways to conduct work can result in making compliance with applicable environmental requirements easier to achieve. Finally, as cleanup activities at sites are completed, the EM program can focus attention and resources on the small number of sites with more complex cleanup challenges. Chapter 1 describes the process by which this report has been developed and what it hopes to accomplish, its relationship to the EM decision-making process, and a general background of the EM mission and program. Chapter 2 describes how the site-by-site projections were constructed, and summarizes, for each of DOE`s 11 Operations/Field Offices, the projected costs and schedules for completing the cleanup mission. Chapter 3 presents summaries of the detailed cleanup projections from three of the 11 Operations/Field Offices: Rocky Flats (Colorado), Richland (Washington), and Savannah River (South Carolina). The remaining eight Operations/Field Office summaries are in Appendix E. Chapter 4 reviews the cost drivers, budgetary constraints, and performance enhancements underlying the detailed analysis of the 353 projects that comprise EM`s accelerated cleanup and closure effort. Chapter 5 describes a management system to support the EM program. Chapter 6 provides responses to the general comments received on the February draft of this document.

  8. Jefferson Lab accelerator upgrade completed: Initial operations...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    visiting scientists may continue commissioning the accelerator and dependent upon funding availability, some limited early physics running may be feasible as the capabilities of...

  9. Collaboration Topics - Acceleration Hardware and APIs | National...

    National Nuclear Security Administration (NNSA)

    Simulation and Computing and Institutional R&D Programs NNSACEA Cooperation in Computer Science Collaboration Topics - Acceleration Hardware and APIs Collaboration...

  10. The Illinois Accelerator Research Center, or IARC,

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    will work side-by-side with industrial partners to develop breakthroughs in accelerator technology and new applications in energy and environment, medicine, industry, national...

  11. Accelerated Climate Modeling for Energy | Argonne Leadership...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Credit: Alan Scott and Mark Taylor, Sandia National Laboratories Accelerated Climate Modeling for Energy PI Name: Mark Taylor PI Email: mataylo@sandia.gov Institution: Sandia...

  12. Accelerator Modeling for Discovery | Argonne Leadership Computing...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    identified three scientific drivers that require accelerator-based experiments (using the Higgs boson as a new tool for discovery, pursuing the physics associated with neutrino...

  13. State Strategies for Accelerating Transmission Development for...

    Open Energy Info (EERE)

    Strategies for Accelerating Transmission Development for Renewable Energy Jump to: navigation, search OpenEI Reference LibraryAdd to library Report: State Strategies for...

  14. Accelerators for Testing Radiation Tolerances of Electronics...

    Office of Science (SC) Website

    Accelerated beams test semiconductor devices for tolerances to space radiation. ... The ability to test in air makes it possible to quickly change components and to easily ...

  15. Offshore Wind Accelerator | Open Energy Information

    Open Energy Info (EERE)

    search Name: Offshore Wind Accelerator Place: United Kingdom Sector: Wind energy Product: Research and development initiative aimed at cutting the cost of offshore wind energy....

  16. Accelerating the transfer in Technology Transfer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Accelerating the transfer in Technology Transfer Community Connections: Your link to news and opportunities from Los Alamos National Laboratory Latest Issue: Dec. 2015-Jan. 2016...

  17. Accelerate program opens doors for nontraditional students

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Accelerate program opens doors for nontraditional students Community Connections: Your link to news and opportunities from Los Alamos National Laboratory Latest Issue: Dec....

  18. DERIVATION OF STOCHASTIC ACCELERATION MODEL CHARACTERISTICS FOR...

    Office of Scientific and Technical Information (OSTI)

    FOR SOLAR FLARES FROM RHESSI HARD X-RAY OBSERVATIONS Citation Details In-Document Search Title: DERIVATION OF STOCHASTIC ACCELERATION MODEL CHARACTERISTICS FOR SOLAR FLARES ...

  19. COMBINED MODELING OF ACCELERATION, TRANSPORT, AND HYDRODYNAMIC...

    Office of Scientific and Technical Information (OSTI)

    Acceleration and transport of high-energy particles and fluid dynamics of ... The interplay of electron heating, conduction, and radiative loss leads to strongermore ...

  20. Modified Accelerated Cost-Recovery System (MACRS)

    Broader source: Energy.gov [DOE]

    Under the federal Modified Accelerated Cost-Recovery System (MACRS), businesses may recover investments in certain property through depreciation deductions. The MACRS establishes a set of class...

  1. Accelerated Laboratory Tests Using Simultaneous UV, Temperature...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Laboratory Tests Using Simultaneous UV, Temperature, and Moisture for PV Encapsulants, Frontsheets, and Backsheets Accelerated Laboratory Tests Using Simultaneous UV, Temperature, ...

  2. 17 GHz High Gradient Accelerator Research

    SciTech Connect (OSTI)

    Temkin, Richard J.; Shapiro, Michael A.

    2013-07-10

    This is a report on the MIT High Gradient Accelerator Research program which has included: Operation of the 17 GHz, 25 MeV MIT/Haimson Research Corp. electron accelerator at MIT, the highest frequency, stand-alone accelerator in the world; collaboration with members of the US High Gradient Collaboration, including the design and test of novel structures at SLAC at 11.4 GHz; the design, construction and testing of photonic bandgap structures, including metallic and dielectric structures; the investigation of the wakefields in novel structures; and the training of the next generation of graduate students and postdoctoral associates in accelerator physics.

  3. Lab seeks venture acceleration initiative partners

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    partners The Venture Acceleration Initiative is a pilot program to strategically spin off from the Lab start-up companies with emphasis on establishing new businesses in...

  4. Educating and Training Accelerator Scientists and Technologists...

    Office of Scientific and Technical Information (OSTI)

    and mechanical engineering. As few universities offer full academic programs, the education of accelerator physicists and engineers for the future has primarily relied on a...

  5. TAP Webinar: High Performance Outdoor Lighting Accelerator

    Broader source: Energy.gov [DOE]

    Hosted by the Technical Assistance Program (TAP), this webinar will cover the recently announced expansion of the Better Buildings platform —the High Performance Outdoor Lighting Accelerator (HPOLA).

  6. Accelerating Climate Technologies: Innovative Market Strategies...

    Open Energy Info (EERE)

    that play a neutral broker role with the private sector. The final marine energy case study proposes a similar approach to accelerate hydrokinetic marine energy technology...

  7. BELLA: The Berkeley Lab Laser Accelerator

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    BELLA: The Berkeley Lab Laser Accelerator Community Berkeley Global Campus Environmental Documents Tours Community Programs Friends of Berkeley Lab Navigate Section Community...

  8. 'Erratic' Lasers Pave Way for Tabletop Accelerators

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Their work was supported by supercomputing resources at the National Energy Research Scientific Computing Center (NERSC). Traditional accelerators, like the Large Hadron Collider ...

  9. Fermilab | Illinois Accelerator Research Center | IARC Facilities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    industrial partners to turn new ideas in accelerator technology into viable commercial products. In addition to the office and classroom space, IARC will have areas for test...

  10. Accelerator Operations and Technology, AOT: LANL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ADE Accelerator and Operations Technology, AOT About Us AOT Home Groups High Power Electrodynamics Instrumentation, Controls Mechanical Design Engineering Operations Radio...

  11. Thomas Jefferson National Accelerator Facility Technology Marketing...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Thomas Jefferson National Accelerator Facility Technology Marketing Summaries Here you'll find marketing summaries for technologies available for licensing from the Thomas...

  12. Accelerated Stress Testing, Qualification Testing, HAST, Field...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Accelerated Stress Testing, Qualification Testing, HAST, Field Experience This presentation, which was the opening session of the NREL 2013 Photovoltaic Module Reliability Workshop ...

  13. Mass spectrometric immunoassay

    DOE Patents [OSTI]

    Nelson, Randall W; Williams, Peter; Krone, Jennifer Reeve

    2013-07-16

    Rapid mass spectrometric immunoassay methods for detecting and/or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for quantification) followed by mass spectrometric analysis of the isolated analyte/internal reference species. Quantification is obtained by normalizing and calibrating obtained mass spectrum against the mass spectrum obtained for an antibody/antigen of known concentration.

  14. Mass spectrometric immunoassay

    DOE Patents [OSTI]

    Nelson, Randall W (Phoenix, AZ); Williams, Peter (Phoenix, AZ); Krone, Jennifer Reeve (Granbury, TX)

    2007-12-04

    Rapid mass spectrometric immunoassay methods for detecting and/or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for quantification) followed by mass spectrometric analysis of the isolated analyte/internal reference species. Quantification is obtained by normalizing and calibrating obtained mass spectrum against the mass spectrum obtained for an antibody/antigen of known concentration.

  15. Mass spectrometric immunoassay

    DOE Patents [OSTI]

    Nelson, Randall W.; Williams, Peter; Krone, Jennifer Reeve

    2005-12-13

    Rapid mass spectrometric immunoassay methods for detecting and/or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for quantification) followed by mass spectrometric analysis of the isolated analyte/internal reference species. Quantification is obtained by normalizing and calibrating obtained mass spectrum against the mass spectrum obtained for an antibody/antigen of known concentration.

  16. Bounding gauged skyrmion masses (Journal Article) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Bounding gauged skyrmion masses Citation Details In-Document Search Title: Bounding gauged skyrmion masses Authors: Brihaye, Yves ; Hill, Christopher T. ; Zachos, Cosmas K. Publication Date: 2004-09-01 OSTI Identifier: 1151557 Report Number(s): ANL-HEP-PR-04-89 DOE Contract Number: AC02-07CH11359 Resource Type: Journal Article Research Org: Fermi National Accelerator Laboratory (FNAL), Batavia, IL Sponsoring Org: USDOE Office of Science (SC), High Energy Physics (HEP) (SC-25) Country of

  17. Imaging mass spectrometer with mass tags

    DOE Patents [OSTI]

    Felton, James S.; Wu, Kuang Jen; Knize, Mark G.; Kulp, Kristen S.; Gray, Joe W.

    2010-06-01

    A method of analyzing biological material by exposing the biological material to a recognition element, that is coupled to a mass tag element, directing an ion beam of a mass spectrometer to the biological material, interrogating at least one region of interest area from the biological material and producing data, and distributing the data in plots.

  18. Imaging mass spectrometer with mass tags

    DOE Patents [OSTI]

    Felton, James S.; Wu, Kuang Jen J.; Knize, Mark G.; Kulp, Kristen S.; Gray, Joe W.

    2013-01-29

    A method of analyzing biological material by exposing the biological material to a recognition element, that is coupled to a mass tag element, directing an ion beam of a mass spectrometer to the biological material, interrogating at least one region of interest area from the biological material and producing data, and distributing the data in plots.

  19. Application of Spatially Resolved High Resolution Crystal Spectrometry...

    Office of Scientific and Technical Information (OSTI)

    Crystal Spectrometry to ICF Plasmas Kenneth W. Hill, et. al. 70 PLASMA PHYSICS AND FUSION TECHNOLOGY High Temperature High Temperature High resolution (3; 10 000) 1D...

  20. Accelerator Production Options for 99MO

    SciTech Connect (OSTI)

    Bertsche, Kirk; /SLAC

    2010-08-25

    Shortages of {sup 99}Mo, the most commonly used diagnostic medical isotope, have caused great concern and have prompted numerous suggestions for alternate production methods. A wide variety of accelerator-based approaches have been suggested. In this paper we survey and compare the various accelerator-based approaches.

  1. Notes on beam dynamics in linear accelerators

    SciTech Connect (OSTI)

    Gluckstern, R.L.

    1980-09-01

    A collection of notes, on various aspects of beam dynamics in linear accelerators, which were produced by the author during five years (1975 to 1980) of consultation for the LASL Accelerator Technology (AT) Division and Medium-Energy Physics (MP) Division is presented.

  2. Fermi National Accelerator Laboratory June 2012

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    recorded two distinct top-quark production mechanisms Explored a new mass range for the Higgs boson and constrained its mass through top-quark and W-boson mass measurements...

  3. Neutron spectrometry for ${\\rm UF}_6$ enrichment verification in storage cylinders

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Mengesha, Wondwosen; Kiff, Scott D.

    2015-01-29

    Verification of declared UF6 enrichment and mass in storage cylinders is of great interest in nuclear material nonproliferation. Nondestructive assay (NDA) techniques are commonly used for safeguards inspections to ensure accountancy of declared nuclear materials. Common NDA techniques used include gamma-ray spectrometry and both passive and active neutron measurements. In the present study, neutron spectrometry was investigated for verification of UF6 enrichment in 30B storage cylinders based on an unattended and passive measurement approach. MCNP5 and Geant4 simulated neutron spectra, for selected UF6 enrichments and filling profiles, were used in the investigation. The simulated neutron spectra were analyzed using principalmore »component analysis (PCA). The PCA technique is a well-established technique and has a wide area of application including feature analysis, outlier detection, and gamma-ray spectral analysis. Results obtained demonstrate that neutron spectrometry supported by spectral feature analysis has potential for assaying UF6 enrichment in storage cylinders. The results from the present study also showed that difficulties associated with the UF6 filling profile and observed in other unattended passive neutron measurements can possibly be overcome using the approach presented.« less

  4. Neutron spectrometry for UF6 enrichment verification in storage cylinders

    SciTech Connect (OSTI)

    Mengesha, Wondwosen; Kiff, Scott D.

    2015-01-29

    Verification of declared UF6 enrichment and mass in storage cylinders is of great interest in nuclear material nonproliferation. Nondestructive assay (NDA) techniques are commonly used for safeguards inspections to ensure accountancy of declared nuclear materials. Common NDA techniques used include gamma-ray spectrometry and both passive and active neutron measurements. In the present study, neutron spectrometry was investigated for verification of UF6 enrichment in 30B storage cylinders based on an unattended and passive measurement approach. MCNP5 and Geant4 simulated neutron spectra, for selected UF6 enrichments and filling profiles, were used in the investigation. The simulated neutron spectra were analyzed using principal component analysis (PCA). The PCA technique is a well-established technique and has a wide area of application including feature analysis, outlier detection, and gamma-ray spectral analysis. Results obtained demonstrate that neutron spectrometry supported by spectral feature analysis has potential for assaying UF6 enrichment in storage cylinders. The results from the present study also showed that difficulties associated with the UF6 filling profile and observed in other unattended passive neutron measurements can possibly be overcome using the approach presented.

  5. NMIS With Gamma Spectrometry for Attributes of Pu and HEU, Explosives and Chemical Agents

    SciTech Connect (OSTI)

    Mihalczo, J. T.; Mattingly, J. K.; Mullens, J. A.; Neal, J. S.

    2002-05-10

    The concept for the system described herein is an active/passive Nuclear Materials Identification System{sup 2} (NMIS) that incorporates gamma ray spectrometry{sup 3}. This incorporation of gamma ray spectrometry would add existing capability into this system. This Multiple Attribute System can determine a wide variety of attributes for Pu and highly enriched uranium (HEU) of which a selected subset could be chosen. This system can be built using commercial off the shelf (COTS) components. NMIS systems are at All-Russian Scientific Research Institute of Experimental Physics (VNIIEF) and Russian Federal Nuclear Center Institute of Technical Physics, (VNIITF) and measurements with Pu have been performed at VNIIEF and analyzed successfully for mass and thickness of Pu. NMIS systems are being used successfully for HEU at the Y-12 National Security Complex. The use of active gamma ray spectrometry for high explosive HE and chemical agent detection is a well known activation analysis technique, and it is incorporated here. This report describes the system, explains the attribute determination methods for fissile materials, discusses technical issues to be resolved, discusses additional development needs, presents a schedule for building from COTS components, and assembly with existing components, and discusses implementation issues such as lack of need for facility modification and low radiation exposure.

  6. Variable energy constant current accelerator structure

    DOE Patents [OSTI]

    Anderson, O.A.

    1988-07-13

    A variable energy, constant current ion beam accelerator structure is disclosed comprising an ion source capable of providing the desired ions, a pre-accelerator for establishing an initial energy level, a matching/pumping module having means for focusing means for maintaining the beam current, and at least one main accelerator module for continuing beam focus, with means capable of variably imparting acceleration to the beam so that a constant beam output current is maintained independent of the variable output energy. In a preferred embodiment, quadrupole electrodes are provided in both the matching/pumping module and the one or more accelerator modules, and are formed using four opposing cylinder electrodes which extend parallel to the beam axis and are spaced around the beam at 90/degree/ intervals with opposing electrodes maintained at the same potential. 12 figs., 3 tabs.

  7. ACCELERATING POLARIZED PROTONS TO HIGH ENERGY.

    SciTech Connect (OSTI)

    BAI, M.; AHRENS, L.; ALEKSEEV, I.G.; ALESSI, J.; BEEBE-WANG, J.; BLASKIEWICZ, M.; BRAVAR, A.; BRENNAN, J.M.; BRUNO, D.; BUNCE, G.; ET AL.

    2006-10-02

    The Relativistic Heavy Ion Collider (RHIC) is designed to provide collisions of high energy polarized protons for the quest of understanding the proton spin structure. Polarized proton collisions at a beam energy of 100 GeV have been achieved in RHIC since 2001. Recently, polarized proton beam was accelerated to 250 GeV in RHIC for the first time. Unlike accelerating unpolarized protons, the challenge for achieving high energy polarized protons is to fight the various mechanisms in an accelerator that can lead to partial or total polarization loss due to the interaction of the spin vector with the magnetic fields. We report on the progress of the RHIC polarized proton program. We also present the strategies of how to preserve the polarization through the entire acceleration chain, i.e. a 200 MeV linear accelerator, the Booster, the AGS and RHIC.

  8. Accelerating Polarized Protons to High Energy

    SciTech Connect (OSTI)

    Bai, M.; Ahrens, L.; Alekseev, I. G.; Alessi, J.; Beebe-Wang, J.; Blaskiewicz, M.; Bravar, A.; Brennan, J. M.; Bruno, D.; Bunce, G.; Butler, J.; Cameron, P.; Connolly, R.; Delong, J.; D'Ottavio, T.; Drees, A.; Fischer, W.; Ganetis, G.; Gardner, C.; Glenn, J.

    2007-06-13

    The Relativistic Heavy Ion Collider (RHIC) is designed to provide collisions of high energy polarized protons for the quest of understanding the proton spin structure. Polarized proton collisions at a beam energy of 100 GeV have been achieved in RHIC since 2001. Recently, polarized proton beam was accelerated to 250 GeV in RHIC for the first time. Unlike accelerating unpolarized protons, the challenge for achieving high energy polarized protons is to fight the various mechanisms in an accelerator that can lead to partial or total polarization loss due to the interaction of the spin vector with the magnetic fields. We report on the progress of the RHIC polarized proton program. We also present the strategies of how to preserve the polarization through the entire acceleration chain, i.e. a 200 MeV linear accelerator, the Booster, the AGS and RHIC.

  9. New directions in optical atomic spectrometry

    SciTech Connect (OSTI)

    de Galan, L.

    1986-05-01

    Soon after its invention a successful method of analysis goes through a phase of rapid growth and exaggerated expectations before it recedes to a more balanced position in the analytical domain. Flame and furnace atomic absorption spectrometry (AAS) and inductively coupled plasma-atomic emission spectrometry (ICP-AES), as we know them now, were introduced 20 to 30 years ago, developed into commercial instruments within a decade after their first description in the scientific literature, and have now reached a state of developmental equilibrium. It is undeniable that these techniques have continued to develop, but recent advances have been largely technical and cosmetic. The emphasis on automation and software has made life much easier and has significantly reduced the demand for manpower, but it has not enlarged the analytical scope of the techniques. Many initial promises have been fulfilled, but some shortcomings persist even today. At this point it would be easy to formulate the ideal method that determines all elements from the sub-parts-per-billion level to the 100% level, simultaneously, with high precision and accuracy, and at minimal cost. Clearly, no single method can possibly match such unrealistic expectations. In this article the author has, therefore, chosen the more modest approach of identifying some weak points in available technology and analyzing possible remedies. In several cases current developments are reviewed, and novel instruments proposed in the literature are evaluated. In other cases, the problems have hardly been addressed and thus may pose a challenge for future research. 10 references, 6 tables.

  10. Elbow mass flow meter

    DOE Patents [OSTI]

    McFarland, Andrew R. (College Station, TX); Rodgers, John C. (Santa Fe, NM); Ortiz, Carlos A. (Bryan, TX); Nelson, David C. (Santa Fe, NM)

    1994-01-01

    Elbow mass flow meter. The present invention includes a combination of an elbow pressure drop generator and a shunt-type mass flow sensor for providing an output which gives the mass flow rate of a gas that is nearly independent of the density of the gas. For air, the output is also approximately independent of humidity.

  11. Spectral properties of laser-accelerated mid-Z MeV/u ion beams

    SciTech Connect (OSTI)

    Hegelich, B.M.; Albright, B.; Cobble, J.; Gautier, C.; Johnson, R.; Letzring, S.; Fernandez, J.C. [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Audebert, P.; Fuchs, J. [Laboratoire pour l'Utilisation des Lasers Intenses, Ecole Polytechnique, 91128 Palaiseau (France); Blazevic, A.; Brambrink, E.; Geissel, M.; Roth, M. [Technische Universitaet Darmstadt, 64289 Darmstadt (Germany); Cowan, T.; Kemp, A. [Physics Department, MS-220, University of Nevada, Reno, Nevada 89557 (United States); Gauthier, J.C. [Centre Lasers Intenses et Applications (CELIA), UMR 5107 CNRS, Universite Bordeaux 1, CEA, Universite Bordeaux 1, 33405 Talence (France); Habs, D.; Schramm, U.; Schreiber, J. [Ludwig-Maximilian Universitaet Muenchen, 85748 Garching (Germany); Karsch, S. [Max-Planck-Institut fuer Quantenoptik, 85748 Garching (Germany)] (and others)

    2005-05-15

    Collimated jets of beryllium, carbon, oxygen, fluorine, and palladium ions with >1 MeV/nucleon energies are observed from the rear surface of thin foils irradiated with laser intensities of up to 5x10{sup 19} W/cm{sup 2}. The normally dominant proton acceleration is suppressed when the target is subjected to Joule heating to remove hydrogen-bearing contaminant. This inhibits screening effects and permits effective energy transfer to and acceleration of heavier ion species. The influence of remnant protons on the spectral shape of the next highest charge-to-mass ratio species is shown. Particle-in-cell simulations confirming the experimental findings are presented.

  12. American Recovery and Reinvestment Act Accelerated Milestones

    Office of Environmental Management (EM)

    RECOVERY PROJECT OR ACTIVITY / ACCELERATED MILESTONE TITLE MILESTONE DUE DATE EXPECTED ACCELERATED COMPLETION DATE WITH ARRA FUNDING STATUS INL - Cleanup of Surplus Nuclear Facilities -- CPP- 601 / 640 Complex D&D Post 2012 9/30/2011 On Schedule to be Met by Expected Accelerated Completion Date (NOTE: CPP-601 is approximately 2 months ahead of schedule, CPP-640 was completed by the end of April 2010). INL - Cleanup of Surplus Nuclear Facilities -- VCO Lines under TRA-632 building 9/30/2013

  13. TWO-CHANNEL DIELECTRIC WAKE FIELD ACCELERATOR

    SciTech Connect (OSTI)

    Jay L. Hirshfield

    2012-05-30

    Experimental results are reported for test beam acceleration and deflection in a two-channel, cm-scale, rectangular dielectric-lined wakefield accelerator structure energized by a 14-MeV drive beam. The dominant waveguide mode of the structure is at {approx}30 GHz, and the structure is configured to exhibit a high transformer ratio ({approx}12:1). Accelerated bunches in the narrow secondary channel of the structure are continuously energized via Cherenkov radiation that is emitted by a drive bunch moving in the wider primary channel. Observed energy gains and losses, transverse deflections, and changes in the test bunch charge distribution compare favorably with predictions of theory.

  14. Lessons from the Bevatron Accelerator Demolition - 12191

    SciTech Connect (OSTI)

    Harkins, Joseph; Cronin, Robert

    2012-07-01

    The Bevatron accelerator at Lawrence Berkeley National Laboratory is the first DOE accelerator to be demolished. While there are many lessons learned from its demolition, this paper focuses on the following lessons learned that may be useful for other D and D projects: bounding project scope to ensure success, hazards mapping for focused characterization and remediation, establishing radiological evaluation criteria, and forecasting activation products. With D and D of many DOE accelerators likely to occur in the near future, these lessons learned should be considered in planning those projects. These lessons learned are likely to be applicable to other D and D projects as well. (authors)

  15. Kinetics of laser pulse vaporization of uranium dioxide by mass spectrometry

    SciTech Connect (OSTI)

    Tsai, C.

    1981-11-01

    Safety analyses of nuclear reactors require knowledge of the evaporation behavior of UO/sub 2/ at temperatures well above the melting point of 3140 K. In this study, rapid transient heating of a small spot on a UO/sub 2/ specimen was accomplished by a laser pulse, which generates a surface temperature excursion. This in turn vaporizes the target surface and the gas expands into vacuum. The surface temperature transient was monitored by a fast-response automatic optical pyrometer. The maximum surface temperatures investigated range from approx. 3700 K to approx. 4300 K. A computer program was developed to simulate the laser heating process and calculate the surface temperature evolution. The effect of the uncertainties of the high temperature material properties on the calculation was included in a sensitivity study for UO/sub 2/ vaporization. The measured surface temperatures were in satisfactory agreements.

  16. Demountable direct injection high efficiency nebulizer for inductively coupled plasma mass spectrometry

    DOE Patents [OSTI]

    Montaser, Akbar; Westphal, Craig S.; Kahen, Kaveh; Rutkowski, William F.; Acon, Billy W.

    2006-12-05

    A nebulizer adapted for adjusting a position of a capillary tube contained within the nebulizer is provided. The nebulizer includes an elongated tubular shell having a gas input port and a gas output port, a capillary adjustment adapter for displacing the capillary tube in a lateral direction via a rotational force, and a connector for connecting the elongated tubular shell, the capillary adjustment adapter and the capillary tube.

  17. Metabolomics relative quantitation with mass spectrometry using chemical derivatization and isotope labeling

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    O'Maille, Grace; Go, Eden P.; Hoang, Linh; Want, Elizabeth J.; Smith, Colin; O'Maille, Paul; NordstrÖm, Anders; Morita, Hirotoshi; Qin, Chuan; Uritboonthai, Wilasinee; et al

    2008-01-01

    Comprehensive detection and quantitation of metabolites from a biological source constitute the major challenges of current metabolomics research. Two chemical derivatization methodologies, butylation and amination, were applied to human serum for ionization enhancement of a broad spectrum of metabolite classes, including steroids and amino acids. LC-ESI-MS analysis of the derivatized serum samples provided a significant signal elevation across the total ion chromatogram to over a 100-fold increase in ionization efficiency. It was also demonstrated that derivatization combined with isotopically labeled reagents facilitated the relative quantitation of derivatized metabolites from individual as well as pooled samples.

  18. Enhancement of concentration range of chromatographically detectable components with array detector mass spectrometry

    DOE Patents [OSTI]

    Enke, Christie

    2013-02-19

    Methods and instruments for high dynamic range analysis of sample components are described. A sample is subjected to time-dependent separation, ionized, and the ions dispersed with a constant integration time across an array of detectors according to the ions m/z values. Each of the detectors in the array has a dynamically adjustable gain or a logarithmic response function, producing an instrument capable of detecting a ratio of responses or 4 or more orders of magnitude.

  19. Dilution-Free Analysis from Picoliter Droplets by Nano-Electrospray Ionization Mass Spectrometry

    SciTech Connect (OSTI)

    Kelly, Ryan T.; Page, Jason S.; Marginean, Ioan; Tang, Keqi; Smith, Richard D.

    2009-09-01

    The expanding role of microfluidics for chemical and biochemical analysis is due to factors including the favorable scaling of separation performance with reduced channel dimensions,[1] flexibility afforded by computer-aided device design, and the ability to integrate multiple sample handling and analysis steps into a single platform.[2] Such devices enable smaller liquid volumes and sample sizes to be handled than can be achieved on the benchtop, where sub-microliter volumes are difficult to work with and where sample losses to the surfaces of multiple reaction vessels become prohibitive. A particularly attractive microfluidic platform for sample-limited analyses employs aqueous droplets or plugs encapsulated by an immiscible oil.[3,4] Each droplet serves as a discrete compartment or reaction chamber enabling, e.g., high throughput screening[5,6] and kinetic studies[7-9] of femto- to nanoliter samples, as well as the encapsulation[10-12] and lysis[10] of individual cells with limited dilution of the cellular contents

  20. High resolution mass spectrometry method and system for analysis of whole proteins and other large molecules

    DOE Patents [OSTI]

    Reilly, Peter T. A. (Knoxville, TN) [Knoxville, TN; Harris, William A. (Naperville, IL) [Naperville, IL

    2010-03-02

    A matrix assisted laser desorption/ionization (MALDI) method and related system for analyzing high molecular weight analytes includes the steps of providing at least one matrix-containing particle inside an ion trap, wherein at least one high molecular weight analyte molecule is provided within the matrix-containing particle, and MALDI on the high molecular weight particle while within the ion trap. A laser power used for ionization is sufficient to completely vaporize the particle and form at least one high molecular weight analyte ion, but is low enough to avoid fragmenting the high molecular weight analyte ion. The high molecular weight analyte ion is extracted out from the ion trap, and is then analyzed using a detector. The detector is preferably a pyrolyzing and ionizing detector.

  1. Method and apparatuses for ion cyclotron spectrometry

    DOE Patents [OSTI]

    Dahl, David A. (Idaho Falls, ID); Scott, Jill R. (Idaho Falls, ID); McJunkin, Timothy R. (Idaho Falls, ID)

    2012-03-06

    An ion cyclotron spectrometer may include a vacuum chamber that extends at least along a z-axis and means for producing a magnetic field within the vacuum chamber so that a magnetic field vector is generally parallel to the z-axis. The ion cyclotron spectrometer may also include means for producing a trapping electric field within the vacuum chamber. The trapping electric field may comprise a field potential that, when taken in cross-section along the z-axis, includes at least one section that is concave down and at least one section that is concave up so that ions traversing the field potential experience a net magnetron effect on a cyclotron frequency of the ions that is substantially equal to zero. Other apparatuses and a method for performing ion cyclotron spectrometry are also disclosed herein.

  2. Accelerated Application Development: The ORNL Titan Experience

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Joubert, Wayne; Archibald, Richard K.; Berrill, Mark A.; Brown, W. Michael; Eisenbach, Markus; Grout, Ray; Larkin, Jeff; Levesque, John; Messer, Bronson; Norman, Matthew R.; et al

    2015-05-09

    The use of computational accelerators such as NVIDIA GPUs and Intel Xeon Phi processors is now widespread in the high performance computing community, with many applications delivering impressive performance gains. However, programming these systems for high performance, performance portability and software maintainability has been a challenge. In this paper we discuss experiences porting applications to the Titan system. Titan, which began planning in 2009 and was deployed for general use in 2013, was the first multi-petaflop system based on accelerator hardware. To ready applications for accelerated computing, a preparedness effort was undertaken prior to delivery of Titan. In this papermore » we report experiences and lessons learned from this process and describe how users are currently making use of computational accelerators on Titan.« less

  3. Relativistic electron acceleration by oblique whistler waves

    SciTech Connect (OSTI)

    Yoon, Peter H.; School of Space Research, Kyung Hee University, Yongin-Si, Gyeonggi-Do 446-701 ; Pandey, Vinay S.; Lee, Dong-Hun

    2013-11-15

    Test-particle simulations of electrons interacting with finite-amplitude, obliquely propagating whistler waves are carried out in order to investigate the acceleration of relativistic electrons by these waves. According to the present findings, an efficient acceleration of relativistic electrons requires a narrow range of oblique propagation angles, close to the whistler resonance cone angle, when the wave amplitude is held constant at relatively low value. For a constant wave propagation angle, it is found that a range of oblique whistler wave amplitudes permits the acceleration of relativistic electrons to O(MeV) energies. An initial distribution of test electrons is shown to form a power-law distribution when plotted in energy space. It is also found that the acceleration is largely uniform in electron pitch-angle space.

  4. Venture Acceleration Fund wins entrepreneurship award

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    aims to help entrepreneurs and businesses reach the next level of success and grow the economy in Northern New Mexico. About the Venture Acceleration Fund The VAF is a...

  5. Sequential injection gas guns for accelerating projectiles

    DOE Patents [OSTI]

    Lacy, Jeffrey M. (Idaho Falls, ID); Chu, Henry S. (Idaho Falls, ID); Novascone, Stephen R. (Idaho Falls, ID)

    2011-11-15

    Gas guns and methods for accelerating projectiles through such gas guns are described. More particularly, gas guns having a first injection port located proximate a breech end of a barrel and a second injection port located longitudinally between the first injection port and a muzzle end of the barrel are described. Additionally, modular gas guns that include a plurality of modules are described, wherein each module may include a barrel segment having one or more longitudinally spaced injection ports. Also, methods of accelerating a projectile through a gas gun, such as injecting a first pressurized gas into a barrel through a first injection port to accelerate the projectile and propel the projectile down the barrel past a second injection port and injecting a second pressurized gas into the barrel through the second injection port after passage of the projectile and to further accelerate the projectile are described.

  6. American Recovery and Reinvestment Act Accelerated Milestones

    Office of Environmental Management (EM)

    7242012 September-11 On Schedule to be Met by Expected Accelerated Completion Date. Biology Complex D&D (scope does not include the main 9207 Biology building) -- WHP 2025...

  7. Accelerator Design and Development | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    physics. In order to further develop our understanding of matter and the fabric of the cosmos, we must continue to expand the horizon of accelerator technology. We need to be able...

  8. Gateway for Accelerated Innovation in Nuclear

    Broader source: Energy.gov [DOE]

    In November 2015, DOE announced it is establishing the Gateway for Accelerated Innovation in Nuclear (GAIN) to provide the nuclear energy community with access to the technical, regulatory, and...

  9. Feature Clustering for Accelerating Parallel Coordinate Descent

    SciTech Connect (OSTI)

    Scherrer, Chad; Tewari, Ambuj; Halappanavar, Mahantesh; Haglin, David J.

    2012-12-06

    We demonstrate an approach for accelerating calculation of the regularization path for L1 sparse logistic regression problems. We show the benefit of feature clustering as a preconditioning step for parallel block-greedy coordinate descent algorithms.

  10. Extending the frontiers of mass spectrometric instrumentation and methods

    SciTech Connect (OSTI)

    Schieffer, Gregg

    2010-12-15

    The focus of this dissertation is two-fold: developing novel analysis methods using mass spectrometry and the implementation and characterization of a novel ion mobility mass spectrometry instrumentation. The novel mass spectrometry combines ion trap for ion/ion reactions coupled to an ion mobility cell. The long term goal of this instrumentation is to use ion/ion reactions to probe the structure of gas phase biomolecule ions. The three ion source - ion trap - ion mobility - qTOF mass spectrometer (IT - IM - TOF MS) instrument is described. The analysis of the degradation products in coal (Chapter 2) and the imaging plant metabolites (Appendix III) fall under the methods development category. These projects use existing commercial instrumentation (JEOL AccuTOF MS and Thermo Finnigan LCQ IT, respectively) for the mass analysis of the degraded coal products and the plant metabolites, respectively. The coal degradation paper discusses the use of the DART ion source for fast and easy sample analysis. The sample preparation consisted of a simple 50 fold dilution of the soluble coal products in water and placing the liquid in front of the heated gas stream. This is the first time the DART ion source has been used for analysis of coal. Steven Raders under the guidance of John Verkade came up with the coal degradation projects. Raders performed the coal degradation reactions, worked up the products, and sent them to me. Gregg Schieffer developed the method and wrote the paper demonstrating the use of the DART ion source for the fast and easy sample analysis. The plant metabolite imaging project extends the use of colloidal graphite as a sample coating for atmospheric pressure LDI. DC Perdian and I closely worked together to make this project work. Perdian focused on building the LDI setup whereas Schieffer focused on the MSn analysis of the metabolites. Both Perdian and I took the data featured in the paper. Perdian was the primary writer of the paper and used it as a chapter in his dissertation. Perdian and Schieffer worked together to address the revisions and publish it in Rapid Communications in Mass Spectrometry Journal.

  11. Radio frequency quadrupole resonator for linear accelerator

    DOE Patents [OSTI]

    Moretti, Alfred

    1985-01-01

    An RFQ resonator for a linear accelerator having a reduced level of interfering modes and producing a quadrupole mode for focusing, bunching and accelerating beams of heavy charged particles, with the construction being characterized by four elongated resonating rods within a cylinder with the rods being alternately shorted and open electrically to the shell at common ends of the rods to provide an LC parallel resonant circuit when activated by a magnetic field transverse to the longitudinal axis.

  12. Application accelerator system having bunch control

    DOE Patents [OSTI]

    Wang, Dunxiong (Newport News, VA); Krafft, Geoffrey Arthur (Newport News, VA)

    1999-01-01

    An application accelerator system for monitoring the gain of a free electron laser. Coherent Synchrotron Radiation (CSR) detection techniques are used with a bunch length monitor for ultra short, picosec to several tens of femtosec, electron bunches. The monitor employs an application accelerator, a coherent radiation production device, an optical or beam chopping device, an infrared radiation collection device, a narrow-banding filter, an infrared detection device, and a control.

  13. Particle accelerator employing transient space charge potentials

    DOE Patents [OSTI]

    Post, Richard F. (Walnut Creek, CA)

    1990-01-01

    The invention provides an accelerator for ions and charged particles. The plasma is generated and confined in a magnetic mirror field. The electrons of the plasma are heated to high temperatures. A series of local coils are placed along the axis of the magnetic mirror field. As an ion or particle beam is directed along the axis in sequence the coils are rapidly pulsed creating a space charge to accelerate and focus the beam of ions or charged particles.

  14. Induction linear accelerator technology for SDIO applications

    SciTech Connect (OSTI)

    Birx, D.; Reginato, L.; Rogers, D.; Trimble, D.

    1986-11-01

    The research effort reported concentrated primarily on three major activities. The first was aimed at improvements in the accelerator drive system of an induction linac to meet the high repetition rate requirements of SDI applications. The second activity centered on a redesign of the accelerator cells to eliminate the beam breakup instabilities, resulting in optimized beam transport. The third activity sought to improve the source of electrons to achieve a higher quality beam to satisfy the requirement of the free electron laser. (LEW)

  15. Accelerated Molecular Dynamics Methods | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Molecular Dynamics Methods Accelerated Molecular Dynamics Methods This presentation on Accelerated Molecular Dynamics Methods was given at the DOE Theory Focus Session on Hydrogen Storage Materials on May 18, 2006. PDF icon storage_theory_session_voter.pdf More Documents & Publications Simulations of Kinetic Events at the Atomic Scale Transportation, Aging and Disposal Canister System Performance Specification: Revision 1 Waste Characterization, Reduction, and Repackaging Facility (WCRRF)

  16. Venture Acceleration Fund now accepting 2012 applications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Venture Acceleration Fund now accepting 2012 applications Venture Acceleration Fund now accepting 2012 applications The three companies selected will receive up to $100,000 each to commercialize technology and take it to market faster. January 23, 2012 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and

  17. Fermi National Accelerator Laboratory September 2012

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fermi National Accelerator Laboratory September 2012 Tritium, which has a half-life of 12.3 years, is an expected byproduct of accelerator operations at Fermilab. As part of our environmental monitoring program, we regularly sample the water discharged into the creeks on site and report the results to the Illinois Environmental Protection Agency, as required by state regulations. We also regularly test the water in the sanitary sewers. The low levels of tritium found since 2005 in Indian Creek,

  18. Berkeley Lab Particle Accelerator Sets World Record

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Berkeley Lab Particle Accelerator Sets World Record Berkeley Lab Particle Accelerator Sets World Record Simulations at NERSC Help Validate Experimental Laser-Plasma Design December 9, 2014 Contact: Kate Greene, kgreene@lbl.gov, 510-486-4404 particleaccelerator A 9 cm-long capillary discharge waveguide used in BELLA experiments to generate multi-GeV electron beams. The plasma plume has been made more prominent with the use of HDR photography. Image: Roy Kaltschmidt Using one of the most powerful

  19. Fermilab | Directorate | Fermilab Accelerator Advisory Committee

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Accelerator Advisory Committee Meeting of the Fermilab Accelerator Advisory Committee December 8-10, 2015 Charge Agenda (Access Key Required) Closeout Report Final Report October 14-16, 2014 Charge Agenda (Access Key Required) Closeout Report Final Report February 6-8, 2013 Charge Agenda (Access Key Required) Closeout Report Final Report John Galambos (ORNL), Chair Frederick Bordry (CERN) Wolfram Fischer (BNL) Mark Hogan (SLAC) Jens Knobloch (BESSY) Wim Leemans (LBNL) Roland Garoby (CERN)

  20. Lab announces Venture Acceleration Fund recipients

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Venture Acceleration Fund recipients Lab announces Venture Acceleration Fund recipients Adaptive Radio Technologies, Los Alamos Visualization Associates, Mesa Tech International Inc., and ThermaSun Inc. selected as recipients of awards. August 11, 2009 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and

  1. Lab seeks ideas for Venture Acceleration Fund

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Venture Acceleration Fund ideas Lab seeks ideas for Venture Acceleration Fund Projects selected will support LANL's core missions and provide a significant opportunity for new company formation or growth in New Mexico. April 20, 2009 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials. Los

  2. Lab seeks ideas for venture acceleration fund

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Venture acceleration fund Lab seeks ideas for Venture Acceleration Fund The fund will provide investments of up to $100,000 to facilitate projects with regional entrepreneurs, companies, investors, or strategic partners. July 9, 2008 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials. Los

  3. NREL: Wind Research - Market Acceleration and Deployment

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Market Acceleration and Deployment Three participants in the Collegiate Wind Competition work on computer components of a small wind turbine. Photo by U.S. Department of Energy NREL's market acceleration and deployment team provides accurate information that articulates the potential impacts and benefits of wind and water power technologies to state and local communities. In addition, NREL's WINDExchange team focuses its outreach efforts on education, rural economic development, public power

  4. Los Alamos Venture Acceleration Fund accepting

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Funding available for New Mexico businesses February 6, 2013 Los Alamos Venture Acceleration Fund accepting 2013 applications LOS ALAMOS, NEW MEXICO, February 6, 2013-The Venture Acceleration Fund (VAF) of Los Alamos National Security, LLC (LANS), the company that manages and operates Los Alamos National Laboratory for the National Nuclear Security Administration, is accepting applications for the 2013 calendar year. Companies selected will receive awards that can range from $10,000 to $100,000

  5. Accelerating Innovation Webinar Series - Energy Innovation Portal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Accelerating Innovation Webinar Series In partnership with the Battelle Commercialization Council, the Energy Innovation Portal is hosting an Accelerating Innovation webinar series. Each session within this series will highlight cutting edge clean energy innovations featured on the Energy Innovation Portal. During these sessions a researcher or laboratory representative will present on their innovation and hold a Q&A session respond to questions from the audience. Webinar recordings will be

  6. Application accelerator system having bunch control

    DOE Patents [OSTI]

    Wang, D.; Krafft, G.A.

    1999-06-22

    An application accelerator system for monitoring the gain of a free electron laser is disclosed. Coherent Synchrotron Radiation (CSR) detection techniques are used with a bunch length monitor for ultra short, picosec to several tens of femtosec, electron bunches. The monitor employs an application accelerator, a coherent radiation production device, an optical or beam chopping device, an infrared radiation collection device, a narrow-banding filter, an infrared detection device, and a control. 1 fig.

  7. Green Racing Initiative: Accelerating the Use of Advanced Technologies...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Racing Initiative: Accelerating the Use of Advanced Technologies & Renewable Fuels Green Racing Initiative: Accelerating the Use of Advanced Technologies & Renewable Fuels 2011 DOE...

  8. Symplectic Maps and Chromatic Optics in Particle Accelerators...

    Office of Scientific and Technical Information (OSTI)

    Symplectic Maps and Chromatic Optics in Particle Accelerators Citation Details In-Document Search Title: Symplectic Maps and Chromatic Optics in Particle Accelerators You are...

  9. Latest Plasma Wakefield Acceleration Results from the FACET Project...

    Office of Scientific and Technical Information (OSTI)

    Latest Plasma Wakefield Acceleration Results from the FACET Project Citation Details In-Document Search Title: Latest Plasma Wakefield Acceleration Results from the FACET Project...

  10. Results From Plasma Wakefield Acceleration Experiments at FACET...

    Office of Scientific and Technical Information (OSTI)

    Results From Plasma Wakefield Acceleration Experiments at FACET Citation Details In-Document Search Title: Results From Plasma Wakefield Acceleration Experiments at FACET Authors:...

  11. 2010 Annual Planning Summary for Stanford Linear Accelerator...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Stanford Linear Accelerator Center Site Office (SLAC) 2010 Annual Planning Summary for Stanford Linear Accelerator Center Site Office (SLAC) Annual Planning Summaries briefly...

  12. Industrial SEP Ratepayer-funded Accelerator Factsheet | Department...

    Office of Environmental Management (EM)

    SEP Ratepayer-funded Accelerator Factsheet Industrial SEP Ratepayer-funded Accelerator Factsheet PDF icon Factsheet.pdf More Documents & Publications SEP Overview Slides Superior...

  13. Solar Technology Acceleration Center is Powering Up - News Releases...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Solar Technology Acceleration Center is Powering Up October 21, 2009 Members of the Solar Technology Acceleration Center (SolarTAC) and supporters convened in Aurora, Colo., today, ...

  14. Energy Department Announces $11 Million to Accelerate Alternative...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Accelerate Alternative Fuel Use in Medium- and Heavy-Duty Vehicles Energy Department Announces 11 Million to Accelerate Alternative Fuel Use in Medium- and Heavy-Duty Vehicles ...

  15. Development of an Accelerated Ash-Loading Protocol for Diesel...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    an Accelerated Ash-Loading Protocol for Diesel Particulate Filters Development of an Accelerated Ash-Loading Protocol for Diesel Particulate Filters Poster presentation at the 2007...

  16. Results From Plasma Wakefield Acceleration Experiments at FACET...

    Office of Scientific and Technical Information (OSTI)

    at the 2nd International Particle Accelerator Conference (IPAC-2011), San Sebastian, Spain, 4-9 Sep 2011 Research Org: SLAC National Accelerator Laboratory (SLAC) Sponsoring...

  17. Venture Acceleration Fund awards spur investment in Northern...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    VAF awards spur investment in Northern New Mexico Venture Acceleration Fund awards spur investment in Northern New Mexico Proposals are being accepted for Venture Acceleration Fund...

  18. SLAC National Accelerator Laboratory FACET & TEST BEAM FACILITIES...

    Office of Scientific and Technical Information (OSTI)

    Technical Report: SLAC National Accelerator Laboratory FACET & TEST BEAM FACILITIES PROPOSAL Citation Details In-Document Search Title: SLAC National Accelerator Laboratory FACET &...

  19. NETL-Led Laboratory-Industry-Academia Collaboration Is Accelerating...

    Office of Environmental Management (EM)

    NETL-Led Laboratory-Industry-Academia Collaboration Is Accelerating Carbon-Capture Technologies NETL-Led Laboratory-Industry-Academia Collaboration Is Accelerating Carbon-Capture ...

  20. Fact Sheet: Accelerating the Development and Deployment of Advanced...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Fact Sheet: Accelerating the Development and Deployment of Advanced Technology Vehicles, including Battery Electric and Fuel Cell Electric Vehicles Fact Sheet: Accelerating the...