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  1. Solar Policy Environment: Houston

    Broader source: Energy.gov [DOE]

    The City of Houston is committed to achieving a sustainable solar infrastructure through strategic partnerships that address market barriers for solar energy through the Houston Solar Initiative. The initiative is dedicated to this long-term goal while focusing on near- and mid-term results that go beyond demonstration solar projects.

  2. Houston Transforming with Solar Energy | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Houston Transforming with Solar Energy Houston Transforming with Solar Energy January 12, 2010 - 8:54am Addthis Houston is a Solar America Cities participant. | File photo Houston ...

  3. Rhodia Houston Plant Biomass Facility | Open Energy Information

    Open Energy Info (EERE)

    Rhodia Houston Plant Biomass Facility Jump to: navigation, search Name Rhodia Houston Plant Biomass Facility Facility Rhodia Houston Plant Sector Biomass Facility Type Non-Fossil...

  4. University of Houston and City of Houston: Collaboration to Determine Best

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Solutions for Diesel Emission Reductions | Department of Energy Houston and City of Houston: Collaboration to Determine Best Solutions for Diesel Emission Reductions University of Houston and City of Houston: Collaboration to Determine Best Solutions for Diesel Emission Reductions 2005 Diesel Engine Emissions Reduction (DEER) Conference Presentations and Posters 2005_deer_harold.pdf (412.44 KB) More Documents & Publications Design of Integrated Laboratory and Heavy-Duty Emissions Testing

  5. Battleground Energy Recovery Project - Presentation by the Houston...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Battleground Energy Recovery Project - Presentation by the Houston Advanced Research Center, June 2011 Battleground Energy Recovery Project - Presentation by the Houston Advanced ...

  6. DOE Zero Energy Ready Home: Durable Energy Builders, Houston...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    DOE Zero Energy Ready Home: Durable Energy Builders, Houston, Texas DOE Zero Energy Ready Home: Durable Energy Builders, Houston, Texas This DOE Zero Energy Ready Home features...

  7. Sam Houston Electric Coop Inc | Open Energy Information

    Open Energy Info (EERE)

    Houston Electric Coop Inc Jump to: navigation, search Name: Sam Houston Electric Coop Inc Place: Texas Phone Number: 888.444-1207 Website: www.samhouston.net Twitter:...

  8. Houston, Texas: Solar in Action (Brochure), Solar America Cities...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Houston, Texas: Solar in Action (Brochure), Solar America Cities, Energy Efficiency & Renewable Energy (EERE) Houston, Texas: Solar in Action (Brochure), Solar America Cities, ...

  9. Houston's measured steps along the comeback trail

    SciTech Connect (OSTI)

    Gold, P.

    1990-06-18

    The Houston recession of the 1980s, a half dozen years of falling oil, rising bankruptcies and daily foreclosures, still shows in the faces and the demeanor of those who survived it. Today, however, the city is well along the path to recovery. Houston's unemployment rate has stabilized below 5 percent, better than Texas or the nation. More than 4,300 new jobs were created last year alone. From steel manufacturing to petrochemicals and the local hero corporation, Compaq Computer Corp., prospects are looking up. The long-depressed real estate market is attracting investors from Europe, Japan and New York. Venture capital and new business are coming in.

  10. Houston BioFuels Consultants | Open Energy Information

    Open Energy Info (EERE)

    BioFuels Consultants Jump to: navigation, search Name: Houston BioFuels Consultants Place: Kingwood, Texas Zip: 77345 Product: A Houston-based consultancy run by oil industry...

  11. Houston, Texas: Solar in Action (Brochure)

    SciTech Connect (OSTI)

    Not Available

    2011-10-01

    This brochure provides an overview of the challenges and successes of Houston, TX, a 2008 Solar America City awardee, on the path toward becoming a solar-powered community. Accomplishments, case studies, key lessons learned, and local resource information are given.

  12. City of Houston Joins Better Buildings Challenge, Partners with...

    Office of Environmental Management (EM)

    Houston is the latest community to join the Challenge, a public-private partnership that ... 30 million square feet of public and private buildings throughout the city. "As ...

  13. Houston Advanced Research Center HARC | Open Energy Information

    Open Energy Info (EERE)

    Advanced Research Center HARC Jump to: navigation, search Name: Houston Advanced Research Center (HARC) Place: The Woodlands, Texas Zip: 77381 Product: HARC cooperates with...

  14. Houston County, Georgia: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    County, Georgia Byron, Georgia Centerville, Georgia Perry, Georgia Robins AFB, Georgia Warner Robins, Georgia Retrieved from "http:en.openei.orgwindex.php?titleHoustonCounty,...

  15. Houston Smart Grid System Almost Ready for Launch

    Broader source: Energy.gov [DOE]

    Find out Houston is at the forefront of another technological revolution, and thanks to Recovery Act money, is supporting local jobs to implement their electric grid.

  16. Houston County, Alabama: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    Solar Hot Water and Power LLC Places in Houston County, Alabama Ashford, Alabama Avon, Alabama Columbia, Alabama Cottonwood, Alabama Cowarts, Alabama Dothan, Alabama Gordon,...

  17. Sec. Chu Travels to Houston | Department of Energy

    Office of Environmental Management (EM)

    Secretary Chu traveled to Houston, Texas, today to meet with executives from various oil ... This strategy is focused on safely and responsibly developing our oil and gas resources ...

  18. Secretary Chu to Visit Houston to Highlight Obama's State of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    tour a recently completed major energy efficiency upgrade at the Texas Medical Center, and host a State of the Union Town Hall with students from Houston Community College. ...

  19. Houston Pre-Freshman Enrichment Program (Houston PREP). Final report, June 9, 1997--July 25, 1997

    SciTech Connect (OSTI)

    1997-10-01

    The 1997 Houston Pre-Freshman Enrichment Program (PREP) was conducted at the campus of the University of Houston-Downtown from June 9 to July 25, 1997. Program participants were recruited from the Greater Houston Area. All participants were identified as high-achieving students with an interest in learning about the engineering and science professions. The goal of the program was to better prepare our pre-college youth prior to entering college as mathematics, science and engineering majors. The program participants were middle school and high school students from the Aldine, Alief, Channel View, Clear Creek, Cypress-Fairbanks, Fort Bend, Galena Park, Houston, Humble, Katy, Klein, North Forest, Pasadena, Private, and Spring Branch Independent School Districts. Of the 194 students starting the program, 165 students were from economically and socially disadvantage groups under-represented in the engineering and science professions, and 118 of the 194 were women. Our First Year group for 1997 composed of 96% minority and women students. Second and Third Year students combined were 96% minority or women. With financial support from the Center for Computational Sciences and Advanced Distributed Simulation, the Fourth Year Program was added to PREP this year. Twelve students completed the program (83% minority or women).

  20. DOE Zero Energy Ready Home Case Study: M Street Homes, Houston...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    M Street Homes, Houston, TX DOE Zero Energy Ready Home Case Study: M Street Homes, Houston, TX DOE Zero Energy Ready Home Case Study: M Street Homes, Houston, TX Case study of a ...

  1. Houston prefreshman enrichment program (Houston PREP). Final report, June 10, 1996--August 1, 1996

    SciTech Connect (OSTI)

    1996-10-01

    The 1996 Houston Pre-freshman Enrichment Program (PREP) was conducted on the campus of the University of Houston-Downtown from June 10 to August 1, 1996. Program Participants were recruited from the Greater Houston area. All participants were identified as high achieving students with an interest in learning about the engineering and science professions. The goal of the program was to better prepare our pre-college youth prior to entering college as mathematics, science and engineering majors. The program participants were middle school and high school students from the Aldine, Alief, Channel View, Crockett, Cypress-Fairbanks, Fort Bend, Galena Park, Houston, Humble, Katy, Klein, North Forest, Pasadena, Private, and Spring Branch Independent School Districts. Of the 197 students starting the program, 170 completed, 142 students were from economically and socially disadvantage groups underrepresented in the engineering and science professions, and 121 of the 197 were female. Our First Year group for 1996 composed of 96% minority and women students. Our Second and Third Year students were 100% and 93.75% minority or women respectively. This gave an overall minority and female population of 93.75%. This year, special efforts were again made to recruit students from minority groups, which caused a significant increase in qualified applicants. However, due to space limitations, 140 applicants were rejected. Investigative and discovery learning were key elements of PREP. The academic components of the program included Algebraic Structures, Engineering, Introduction to Computer Science, Introduction to Physics, Logic and Its Application to Mathematics, Probability and Statistics, Problem Solving Seminar using computers and PLATO software, SAT Preparatory Seminars, and Technical Writing.

  2. ARM - Field Campaign - 2000 Houston, Texas Air Quality Study

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    0 Houston, Texas Air Quality Study ARM Data Discovery Browse Data Comments? We would love to hear from you! Send us a note below or call us at 1-888-ARM-DATA. Send Campaign : 2000 Houston, Texas Air Quality Study 2000.08.19 - 2000.09.12 Lead Scientist : Peter Daum For data sets, see below. Abstract Over 250 scientists and technicians from over 40 organizations participated in TexAQS 2000, a major air quality study focused on Houston, Texas. The study was one of the largest, most comprehensive

  3. City of Houston- Residential and Commercial Green Building Requirements

    Broader source: Energy.gov [DOE]

    In 2014, the City Council of Houston passed Ordinance No. 2014-5, requiring new residential construction to exceed the energy efficiency requirements under the 2009 International Energy Conservat...

  4. South Houston, Texas: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    article is a stub. You can help OpenEI by expanding it. South Houston is a city in Harris County, Texas. It falls under Texas's 29th congressional district.12 References...

  5. Secretary Chu to Travel to Houston Today | Department of Energy

    Office of Environmental Management (EM)

    ongoing oil spill response efforts U.S. Energy Secretary Steven Chu is making his fifth trip to Houston today to continue to help identify strategies for containing the oil and ...

  6. Alternative Fuels Data Center: Houston Energizes Deployment of Plug-In

    Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

    Electric Vehicles Houston Energizes Deployment of Plug-In Electric Vehicles to someone by E-mail Share Alternative Fuels Data Center: Houston Energizes Deployment of Plug-In Electric Vehicles on Facebook Tweet about Alternative Fuels Data Center: Houston Energizes Deployment of Plug-In Electric Vehicles on Twitter Bookmark Alternative Fuels Data Center: Houston Energizes Deployment of Plug-In Electric Vehicles on Google Bookmark Alternative Fuels Data Center: Houston Energizes Deployment of

  7. City of Houston Joins Better Buildings Challenge, Partners with Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department to Reduce Energy Waste and Boost Efficiency | Department of Energy City of Houston Joins Better Buildings Challenge, Partners with Energy Department to Reduce Energy Waste and Boost Efficiency City of Houston Joins Better Buildings Challenge, Partners with Energy Department to Reduce Energy Waste and Boost Efficiency January 26, 2012 - 2:05pm Addthis Washington, D.C. - Building on President Obama's call in the State of the Union address earlier this week for a new era for American

  8. Houston We have a Solution: University Teams Tackle Efficiency's Barriers

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    | Department of Energy Houston We have a Solution: University Teams Tackle Efficiency's Barriers Houston We have a Solution: University Teams Tackle Efficiency's Barriers March 5, 2012 - 11:00am Addthis Secretary Chu with students from MIT at the Better Buildings Case Competition finale, held in Washington D.C. | Photo by Ken Shipp. Secretary Chu with students from MIT at the Better Buildings Case Competition finale, held in Washington D.C. | Photo by Ken Shipp. Erin R. Pierce Erin R. Pierce

  9. Houston, Texas design/build house. Case study report

    SciTech Connect (OSTI)

    Borden, J. O.; Porter, C. B.

    1981-06-01

    The task activities relating to the Houston house, including problems, constructive comments, and successes, are described. Included in appendices are: cost data, methodology for ranking cities, house information sheet, thermal performance analysis, architectural information release, press releases and news clippings, and house pictures. One appendix was abstracted separately. (MHR)

  10. Microsoft Word - DOE-ID-13-063 Houston EC B3-6.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3 SECTION A. Project Title: NEET-1: Ultra-High Performance Concrete and Advanced Manufacturing Methods for Modular Construction - University of Houston SECTION B. Project...

  11. SU-E-P-02: Imaging and Radiation Oncology Core (IROC) Houston QA Center (RPC) Credentialing

    SciTech Connect (OSTI)

    Amador, C; Keith, T; Nguyen, T; Molineu, A; Followill, D

    2014-06-01

    Purpose: To provide information pertaining to IROC Houston QA Center's (RPC) credentialing process for institutions participating in NCI-sponsored clinical trials. Methods: IROC Houston issues credentials for NCI sponsored study groups. Requirements for credentialing might include any combination of questionnaires, knowledge assessment forms, benchmarks, or phantom irradiations. Credentialing requirements for specific protocols can be found on IROC Houston's website (irochouston.mdanderson.org). The website also houses the credentialing status inquiry (CSI) form. Once an institution has reviewed the protocol's credentialing requirements, a CSI form should be completed and submitted to IROC Houston. This form is used both to request whether requirements have been met as well as to notify IROC Houston that the institution requests credentialing for a specific protocol. IROC Houston will contact the institution to discuss any delinquent requirements. Once the institution has met all requirements IROC Houston issues a credentialing letter to the institution and will inform study groups and other IROC offices of the credentials. Institutions can all phone the IROC Houston office to initiate credentialing or ask any credentialing related questions. Results: Since 2010 IROC has received 1313 credentialing status inquiry forms. We received 317 in 2010, 266 in 2011, 324 in 2012, and 406 in 2013. On average we receive 35 phone calls per week with multiple types of credentialing questions. Decisions regarding credentialing status are based on the protocol specifications and previous completed credentialing by the institution. In some cases, such as for general IMRT credentialing, up to 5 sites may be credentialed based on the credentialing of one main center. Each of these situations is handled individually. Conclusion: IROC Houston will issue radiation therapy credentials for the NCI trials in the National Clinical Trials Network. Credentialing requirements and the CSI form

  12. Photo Release: U.S. Energy Secretary Chu at BP Command Center in Houston |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Release: U.S. Energy Secretary Chu at BP Command Center in Houston Photo Release: U.S. Energy Secretary Chu at BP Command Center in Houston May 28, 2010 - 12:00am Addthis Washington D.C. --- At the request of President Obama, U.S. Energy Secretary Steven Chu has been helping oversee BP's "top kill" efforts from the BP Command Center in Houston. Below are two photographs from this week. Photo credit: Department of Energy. Secretary Steven Chu and National

  13. Reference Buildings by Climate Zone and Representative City: 2A Houston, Texas

    Broader source: Energy.gov [DOE]

    In addition to the ZIP file for each building type, you can directly view the "scorecard" spreadsheet that summarizes the inputs and results for each location. This Microsoft Excel spreadsheet is also included in the ZIP file. For version 1.4, only the IDF file is included.

  14. LSST Science Book, Version 2.0 Abell, Paul A.; /NASA, Houston...

    Office of Scientific and Technical Information (OSTI)

    LSST Science Book, Version 2.0 Abell, Paul A.; NASA, Houston; Allison, Julius; Alabama A-M; Anderson, Scott F.; Washington U., Seattle; Andrew, John R.; NOAO, Tucson; Angel,...

  15. Valero: Houston Refinery Uses Plant-Wide Assessment to Develop an Energy Optimization and Management System

    SciTech Connect (OSTI)

    2005-08-01

    This Industrial Technologies Program case study describes an energy assessment team's recommendations for saving $5 million in energy, water, and other costs at an oil refinery in Houston, Texas.

  16. Battleground Energy Recovery Project- Presentation by the Houston Advanced Research Center, June 2011

    Broader source: Energy.gov [DOE]

    Presentation on the Battleground Energy Recovery Project, given by Dan Bullock of the Houston Advanced Research Center, at the U.S. DOE Industrial Distributed Energy Portfolio Review Meeting in Washington, D.C. on June 1-2, 2011.

  17. Microsoft Word - DOE-ID-14-069 Houston B1-31.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    9 SECTION A. Project Title: Upgrade of Universal Element Tester for Nuclear Energy Infrastructure Research- University of Houston SECTION B. Project Description The University of Houston proposes to purchase and install a computer control system and tele-participation computer system to upgrade the universal element tester that is used to perform biaxial or triaxial tests on full-size concrete elements with load-control and strain-control loading modes. The upgrade will allow further studies of

  18. Microsoft Word - DOE-ID-15-052 Houston EC B3-6.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2 SECTION A. Project Title: Multiple Degradation Mechanisms in Reinforced Concrete Structures, Modeling and Risk Analysis - The University of Houston SECTION B. Project Description The University of Houston proposes to complement ongoing Light Water Reactor Sustainability (LWRS)-funded Grizzly (component aging code) efforts by providing improved multi-physics models that will be incorporated into Grizzly's framework. These new developments include 1) coupling between mechanical damage and

  19. Texas Solar Collaboration DOE Rooftop Solar Challenge City of Houston Project Summary

    SciTech Connect (OSTI)

    Ronk, Jennifer

    2013-02-14

    The City of Houston is committed to achieving a sustainable solar infrastructure. In 2008, Houston was named a United States Department of Energy (DOE) Solar America City. As a Solar America City, Houston teamed with the Houston Advanced Research Center (HARC), Sandia National Laboratory (Sandia), industry, and academia, to implement the Solar Houston Initiative and prepare the Solar Houston Plan. The Solar Houston initiative was focused on identifying and overcoming barriers associated with establishing a solar infrastructure that is incorporated into the City of Houston’s overall energy plan. A broad group of Houston area stakeholders, facilitated by HARC, came together to develop a comprehensive solar plan that went beyond technology to address barriers and establish demonstrations, public outreach, education programs and other activities. The plan included proposed scopes of work in four program areas: policies, solar integration, public outreach, and education. Through the support of the DOE SunShot Rooftop Solar Challenge (RSC) grant to the Texas Collaboration (San Antonio, Austin, and Hosuton), Houston has been able to implement several of the recommendations of the Solar Houston Plan. Specific recommendations that this project was able to support include; Working with the other Texas Solar America Cities (San Antonio and Austin), to harmonize permitting and inspection processes to simplify for installers and lower soft costs of installation; Participating in state level solar policy groups such as the Texas Renewable Energy Industries Association (TRIEA); Continued coordination with the local transmission and distribution utility (CenterPoint) and retail electric providers (REP); Identification of opportunities to improve permitting and interconnection; Providing training on PV systems to City inspectors; Educating the public by continuing outreach, training, and workshops, particularly using the the Green Building Resources Center; Evaluating methods of

  20. Compressed natural gas fueled vehicles: The Houston experience

    SciTech Connect (OSTI)

    Not Available

    1993-12-31

    The report describes the experience of the City of Houston in defining the compressed natural gas fueled vehicle research scope and issues. It details the ways in which the project met initial expectations, and how the project scope, focus, and duration were adjusted in response to unanticipated results. It provides examples of real world successes and failures in efforts to commercialize basic research in adapting a proven technology (natural gas) to a noncommercially proven application (vehicles). Phase one of the demonstration study investigates, develops, documents, and disseminates information regarding the economic, operational, and environmental implications of utilizing compressed natural gas (CNG) in various truck fueling applications. The four (4) truck classes investigated are light duty gasoline trucks, medium duty gasoline trucks, medium duty diesel trucks and heavy duty diesel trucks. The project researches aftermarket CNG conversions for the first three vehicle classes and original equipment manufactured (OEM) CNG vehicles for light duty gasoline and heavy duty diesel classes. In phase two of the demonstration project, critical issues are identified and assessed with respect to implementing use of CNG fueled vehicles in a large vehicle fleet. These issues include defining changes in local, state, and industry CNG fueled vehicle related codes and standards; addressing vehicle fuel storage limitations; using standardized vehicle emission testing procedures and results; and resolving CNG refueling infrastructure implementation issues and related cost factors. The report identifies which CNG vehicle fueling options were tried and failed and which were tried and succeeded, with and without modifications. The conclusions include a caution regarding overly optimistic assessments of CNG vehicle technology at the initiation of the project.

  1. High-quality permanent draft genome sequence of Bradyrhizobium sp. Ai1a-2; a microsymbiont of Andira inermis discovered in Costa Rica

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Tian, Rui; Parker, Matthew; Seshadri, Rekha; Reddy, T. B. K.; Markowitz, Victor; Ivanova, Natalia; Pati, Amrita; Woyke, Tanja; Baeshen, Mohammed; Baeshen, Nabih; et al

    2015-06-14

    Bradyrhizobium sp. Ai1a-2 is is an aerobic, motile, Gram-negative, non-spore-forming rod that was isolated from an effective nitrogen fixing root nodule of Andira inermis collected from Tres Piedras in Costa Rica. In this report we describe, for the first time, the genome sequence information and annotation of this legume microsymbiont. The 9,029,266 bp genome has a GC content of 62.56% with 247 contigs arranged into 246 scaffolds. The assembled genome contains 8,482 protein-coding genes and 102 RNA-only encoding genes. Lastly, this rhizobial genome was sequenced as part of the DOE Joint Genome Institute 2010 Genomic Encyclopedia for Bacteria and Archaea-Rootmore » Nodule Bacteria (GEBA-RNB) project proposal.« less

  2. Secretary Chu to Visit Houston to Highlight Obama’s State of the Union Address, Discuss “All of the Above” Energy Strategy

    Broader source: Energy.gov [DOE]

    Secretary Chu to Visit Major Industrial Efficiency Project, Host State of the Union Town Hall at Houston Community College

  3. DOE Zero Energy Ready Home Case Study: M Street Homes, Houston, TX

    Broader source: Energy.gov [DOE]

    Case study of a DOE Zero Energy Ready home in Houston, TX, that achieves a HERS 45 without PV or HERS 32 with 1.2 kW PV. The three-story, 4,507-ft2 custom home is powered by a unique tri-generation...

  4. Houston, Texas: Solar in Action (Brochure), Solar America Cities, Energy Efficiency & Renewable Energy (EERE)

    Broader source: Energy.gov [DOE]

    This brochure provides an overview of the challenges and successes of Houston, TX, a 2008 Solar America City awardee, on the path toward becoming a solar-powered community. Accomplishments, case studies, key lessons learned, and local resource information are given.

  5. First principles DFT study of ferromagnetism in SnO{sub 2} induced by doped group 1A and 2A non-magnetic elements X (X=Li, Na, K, Be, Mg, Ca)

    SciTech Connect (OSTI)

    Chakraborty, Brahmananda Ramaniah, Lavanya M.

    2014-04-24

    Transition metal - free - ferromagnetism in diluted magnetic semiconductors (DMS) is of much current interest in the search for more efficient DMS materials for spintronic applications. Here, we report the results of our first principles density functional theory (DFT) study on impurity - induced ferromagnetism in non-magnetic SnO{sub 2} by a non-magnetic impurity. The impurities considered are sp-type of group 1A and 2A elements X (X = Li, Na, K, Be, Mg, Ca). Even a single atom of the group 1A elements makes the system magnetic, whereas for the group 2A elements Ca and Mg, a higher doping is required to induce ferromagnetism. For all the elements studied, the magnetic moment appears to increase with the doping concentration, at least at certain impurity separations, which is a positive indicator for practical applications.

  6. Houston County Elec Coop Inc | Open Energy Information

    Open Energy Info (EERE)

    2010 - File1a1 EIA Form 861 Data Utility Id 8898 Utility Location Yes Ownership C NERC Location TRE NERC ERCOT Yes Activity Transmission Yes Activity Distribution Yes Activity...

  7. Best Practices Case Study: David Weekley Homes - Eagle Springs and Waterhaven, Houston, TX

    SciTech Connect (OSTI)

    none,

    2011-04-01

    Case study describing David Weekley Homes, Houston Division, has qualified more than 1,240 homes for the DOE Builders Challenge. Advanced framed 2x6 walls with open headers and two-stud corners allow more room for R-20 damp sprayed cellulose wall cavity insulation that is covered with R-5 rigid XPS foam. A radiant barrier cuts heat gain in the R-38 insulated vented attics. Draft stopping at fireplace and duct chases and behind tubs, gluing sheetrock to framing, and extensive caulking make for air-tight homes at 3.0 ACH50.

  8. DOE Zero Energy Ready Home Case Study 2014: Durable Energy Builders, Houston, TX

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Durable Energy Builders Houston, TX DOE ZERO ENERGY READY HOME(tm) CASE STUDY The U.S. Department of Energy invites home builders across the country to meet the extraordinary levels of excellence and quality specified in DOE's Zero Energy Ready Home program (formerly known as Challenge Home). Every DOE Zero Energy Ready Home starts with ENERGY STAR Certified Homes Version 3.0 for an energy-efficient home built on a solid foundation of building science research. Advanced technologies are designed

  9. Progress Report- DE-FG02-03ER46078-University of Houston

    Office of Scientific and Technical Information (OSTI)

    Final Report- DE-FG02-08ER46486-University of Houston Neutron Compton Scattering as a Probe of Hydrogen Bonded (and other) Systems George Reiter December 22, 2010 Period: Feb 1, 2010-Jan 31, 2011 Summary of work: 3-D Measurements of Born-Oppenheimer Potential Measurements of the momentum distribution of Rb3H(SO4)2 at 120K and 170K have been analyzed, and a paper submitted to PRB. It is now in the review process. The import of the paper is that the effective Born Oppenheimer potential for the

  10. DOE Zero Energy Ready Home Case Study: Durable Energy Builders - Houston, Texas

    SciTech Connect (OSTI)

    none,

    2014-11-01

    This case study describes a DOE Zero Energy Ready Home in Houston, Texas, that scored HERS 39 without PV and HERS 29 with PV. This 5,947 ft2 custom home has 11.5-inch ICF walls. The attic is insulated along the roof line with 5 to 7 inches of open-cell spray foam. Most of the home's drinking water is supplied by a 11,500-gallon rainwater cistern. Hurricane strapping connects the roof to the walls. The triple-pane windows are impact resistant. The foundation is a raised slab.

  11. OPERATION OF A PUBLIC GEOLOGIC CORE AND SAMPLE REPOSITORY IN HOUSTON TEXAS

    SciTech Connect (OSTI)

    Scott W. Tinker

    2003-06-01

    In the spring of 2002, the Department of Energy provided an initial 1-year grant to the Bureau of Economic Geology (BEG) at The University of Texas at Austin (UT). The grant covered the one-year operational expenses of a worldclass core and cuttings facility located in Houston, Texas, that BP America donated to the BEG. The DOE investment of $300,000, matched by a $75,000 UT contribution, provided critical first-year funds that were heavily leveraged by the BP gift of $7.0 million in facilities and cash. DOE also provided a one-month extension and grant of $30,000 for the month of May 2003. A 5-year plan to grow a permanent endowment in order to manage the facility in perpetuity is well under way and on schedule. The facility, named the Houston Research Center, represents an ideal model for a strong Federal, university, and private partnership to accomplish a national good. This report summarizes the activities supported by the initial DOE grant during the first 13 months of operation and provides insight into the activities and needs of the facility in the second year of operation.

  12. Energy efficient low-income housing demonstration with Houston Habitat for Humanity. Final status report, October 1, 1995--September 30, 1997

    SciTech Connect (OSTI)

    1997-09-30

    Using DOE grant funds, the Alliance to Save Energy developed and managed an award-winning low-income housing demonstration in cooperation with Houston Habitat for Humanity at the 1996 and 1997 annual NAHB Builders Show in Houston, Texas. Using a unique group of over 30 national, state and local partners, the energy design of Houston Habitat houses was permanently upgraded to the Energy Star Homes Program threshold. Meeting Energy Star Homes Program criteria, the partner design team increased the level of efficiency approximately 30% over the 1992 Model Energy Code. This innovative design using commercially available materials added approximately $1,400 in cost-effective energy upgrades with an estimated payback of less than 8 years. The 30 public-private partners successfully demonstrated energy and resource efficient housing techniques to the 65,000 NAHB home show attendees and the over 3,000 Habitat affiliates. This project resulted in the Houston Habitat affiliate becoming the nation`s first low-income Energy Star Homes Program home builder. By the year 2000, Houston Habitat anticipates building over 500 homes to this new level of efficiency as well as set an example for other Habitat affiliates nationwide to follow. The 1997 demonstration house utilized an all-women volunteer builders team to construct a 3 bedroom home in Houston Habitat`s Woodglen Subdivision. Energy consumption was remotely metered by Texas A and M.

  13. HVAC Design Strategy for a Hot-Humid Production Builder, Houston, Texas (Fact Sheet)

    SciTech Connect (OSTI)

    Not Available

    2014-03-01

    BSC worked directly with the David Weekley Homes - Houston division to redesign three floor plans in order to locate the HVAC system in conditioned space. The purpose of this project is to develop a cost effective design for moving the HVAC system into conditioned space. In addition, BSC conducted energy analysis to calculate the most economical strategy for increasing the energy performance of future production houses. This is in preparation for the upcoming code changes in 2015. The builder wishes to develop an upgrade package that will allow for a seamless transition to the new code mandate. The following research questions were addressed by this research project: 1. What is the most cost effective, best performing and most easily replicable method of locating ducts inside conditioned space for a hot-humid production home builder that constructs one and two story single family detached residences? 2. What is a cost effective and practical method of achieving 50% source energy savings vs. the 2006 International Energy Conservation Code for a hot-humid production builder? 3. How accurate are the pre-construction whole house cost estimates compared to confirmed post construction actual cost? BSC and the builder developed a duct design strategy that employs a system of dropped ceilings and attic coffers for moving the ductwork from the vented attic to conditioned space. The furnace has been moved to either a mechanical closet in the conditioned living space or a coffered space in the attic.

  14. Land subsidence caused by withdrawal of oil and gas in the Gulf coastal plain - The Houston, Texas, case history

    SciTech Connect (OSTI)

    Holzer, T.L. )

    1990-09-01

    The extensive network of geodetic leveling lines in the Houston-Galveston, Texas, area, where at least 110 oil and gas fields have been developed, provides the most comprehensive opportunity in the Gulf Coast to search for the occurrence of land subsidence caused by withdrawal of oil and gas. Although the evaluation is complicated by regional subsidence caused by a decline of ground-water level in aquifers beneath the area, subsidence caused by oil and gas withdrawal can be examined by searching for local increases of subsidence at oil and gas fields crossed by leveling lines. Twenty-nine fields are crossed by lines with repeated leveling surveys. Subsidence profiles across these fields indicate local increases of subsidence at six fields-Alco-Mag, Chocolate Bayou, Goose Creek, Hastings, Mykawa, and South Houston. Although ground-water withdrawal is undoubtedly the most important factor contributing to the total subsidence at each field, oil and gas withdrawal may be partly responsible for the local increases. Except for Chocolate Bayou, the volume of petroleum production at each field was sufficient to account for the increase. The volume of petroleum production, however, in general is not a reliable index for predicting the local increase because land within many fields with significant production did not show local increases of subsidence. With the exception of the 1 m subsidence caused by petroleum withdrawal at Goose Creek (1917-1925), local increases of subsidence were less than 0.3 m.

  15. HVAC Design Strategy for a Hot-Humid Production Builder, Houston, Texas (Fact Sheet), Building America Case Study: Whole-House Solutions for New Homes, Building Technologies Office (BTO)

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    HVAC Design Strategy for a Hot-Humid Production Builder Houston, Texas PROJECT INFORMATION Construction: New Home Type: Single-family, production builder Builder: David Weekley Homes - Houston www.davidweekleyhomes.com/ new-homes/tx/houston Size: 1,757 ft 2 to 4,169 ft 2 Price Range: about $260,000 to $450,000 Date Completed: 2013 Climate Zone: Hot-humid PERFORMANCE DATA HERS index: Builder standard practice = 66; case study 1,757-ft 2 house = 54 Projected annual energy cost savings: $375

  16. American Recovery and Reinvestment Act Federal Energy Management Program Technical Assistance Project 184 U.S. Customs and Border Protection Laboratory, Houston, Texas

    SciTech Connect (OSTI)

    Arends, J.; Sandusky, William F.

    2010-09-30

    This report documents the findings of an on-site energy audit of the U.S. Customs and Border Protection (CBP) Laboratory in Houston, Texas. The focus of the audit was to identify various no-cost and low-cost energy efficiency opportunities that, once implemented, would reduce electricity and gas consumption and increase the operational efficiency of the building. This audit also provided an opportunity to identify potential capital cost projects that should be considered in the future to acquire additional energy (electric and gas) and water savings to further increase the operational efficiency of the building.

  17. Stem Mentoring Cafe- Houston

    Broader source: Energy.gov [DOE]

    The U.S. Department of Energy is hosting a STEM Mentoring Cafe to engage middle school students in STEM and their teachers with federal STEM professionals, through speed mentoring sessions and a commitment to ongoing mentoring from federal employees.

  18. Energy savings for heat-island reduction strategies in Chicago and Houston (including updates for Baton Rouge, Sacramento, and Salt Lake City)

    SciTech Connect (OSTI)

    Konopacki, S.; Akbari, H.

    2002-02-28

    In 1997, the U.S. Environmental Protection Agency (EPA) established the ''Heat Island Reduction Initiative'' to quantify the potential benefits of Heat-Island Reduction (HIR) strategies (i.e., shade trees, reflective roofs, reflective pavements and urban vegetation) to reduce cooling-energy use in buildings, lower the ambient air temperature and improve urban air quality in cities, and reduce CO2 emissions from power plants. Under this initiative, the Urban Heat Island Pilot Project (UHIPP) was created with the objective of investigating the potential of HIR strategies in residential and commercial buildings in three initial UHIPP cities: Baton Rouge, LA; Sacramento, CA; and Salt Lake City, UT. Later two other cities, Chicago, IL and Houston, TX were added to the UHIPP. In an earlier report we summarized our efforts to calculate the annual energy savings, peak power avoidance, and annual CO2 reduction obtainable from the introduction of HIR strategies in the initial three cities. This report summarizes the results of our study for Chicago and Houston. In this analysis, we focused on three building types that offer the highest potential savings: single-family residence, office and retail store. Each building type was characterized in detail by vintage and system type (i.e., old and new building constructions, and gas and electric heat). We used the prototypical building characteristics developed earlier for each building type and simulated the impact of HIR strategies on building cooling- and heating-energy use and peak power demand using the DOE-2.1E model. Our simulations included the impact of (1) strategically-placed shade trees near buildings [direct effect], (2) use of high-albedo roofing material on the building [direct effect], (3) urban reforestation with high-albedo pavements and building surfaces [indirect effect] and (4) combined strategies 1, 2, and 3 [direct and indirect effects]. We then estimated the total roof area of air-conditioned buildings in

  19. U1A Complex

    ScienceCinema (OSTI)

    None

    2015-01-09

    Some of the most sophisticated experiments in the stockpile stewardship program are conducted in an environmentally safe manner, nearly 1000 feet below the ground at the site. The U1a complex a sprawling underground laboratory and tunnel complex is home to a number of unique capabilities.

  20. Report of the South Texas Project Allegations Review Team. Docket Nos. 50-498 and 50-499, Houston Lighting and Power Company et al.

    SciTech Connect (OSTI)

    Kokajko, L.; Skay, D.; Wang, H.; Murphy, D.

    1995-03-01

    This report provides the results of the South Texas Project Allegations Review Team of the US Nuclear Regulatory Commission. This team was formed to obtain and review allegations from individuals represented by three attorneys who had contacted Congressional staff members. The allegers were employed in various capacities at South Texas Project Electric Generating Station, licensed by Houston Lighting and Power Company, et al.; therefore, the allegations are confined to this site. The South Texas Project Allegations Review Team reviewed, referred, and dispositioned concerns related to discriminatory issues (harassment and intimidation), falsification of records and omission of information, and various technical issues. The team was able to substantiate certain technical issues of minor safety significance or regulatory concern at the South Texas Project facility, but it did not find widespread discriminatory practices such as harassment and intimidation.

  1. Structure of Human Argonaute2: A Programmable Ribonuclease |...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Argonaute2: A Programmable Ribonuclease Wednesday, July 31, 2013 Ribonucleases ... Institute were able to solve the three-dimensional structure of human Argonaute2 (Fig 1A). ...

  2. The Use of Positive Matrix Factorization with Conditional Probability Functions in Air Quality Studies: An Application to Hydrocarbon Emissions in Houston, Texas

    SciTech Connect (OSTI)

    Xie, YuLong; Berkowitz, Carl M.

    2006-06-01

    As part of a study to identify groups of compounds (source categories) associated with different processing facilities, a multivariate receptor model called Positive Matrix Factorization (PMF) was applied to hourly average concentrations of volatile organic compounds (VOCs) measured at five Photochemical Assessment Monitoring Stations (PAMS) located near the Ship Channel in Houston, Texas. The observations were made between June and October, 2003, and limited to nighttime measurements (21:00 pm 6:00 am) in order to remove the complexity of photochemical processing and associated changes in the concentrations of primary and secondary VOCs. Six to eight volatile organic compounds source categories were identified for the five Ship Channel sites. The dominant source categories were found to be those associated with petrochemical, chemical industries and fuel evaporation. In contrast, source categories associated with on-road vehicles were found to be relatively insignificant. Although evidence of biogenic emissions was found at almost all the sites, this broad category was significant only at the Wallisville site, which was also the site furthest away from the Ship Channels area and closest to the northeast forest of Texas. Natural gas, accumulation and fuel evaporation sources were found to contribute most to the ambient VOCs, followed by the petrochemical emission of highly reactive ethene and propylene. Solvent / paint industry and fuel evaporation and emission from refineries were next in importance while the on-road vehicle exhaust generally contributed less than 10% of the total ambient VOCs. Specific geographic areas associated with each source category were identified through the use of a Conditional Probability Function (CPF) analysis that related elevated concentrations of key VOCs in each category to a network of grids superimposed on the source inventories of the VOCs.

  3. University of Houston and City of Houston: Collaboration to Determine...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    More Documents & Publications Design of Integrated Laboratory and Heavy-Duty Emissions Testing Center Combining Biodiesel and EGR for Low-Temperature NOx and PM Reductions ...

  4. Th1A.2.pdf

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Th1A.2.pdf OFC 2015 © OSA 2015 WAN Virtualization and Dynamic End-to-End Bandwidth Provisioning Using SDN Adrian Lara 1 , Byrav Ramamurthy 1 , Eric Pouyoul 2 and Inder Monga 2 1 University of Nebraska-Lincoln, Lincoln NE 68504 {alara,byrav}@cse.unl.edu 2 Energy Science Network, Lawrence Berkeley National Laboratory, Berkeley CA 94720 {lomax,imonga}@es.net Abstract: We evaluate a WAN-virtualization framework in terms of delay and scalability and demonstrate that adding a virtual layer between

  5. Climate Zone 1A | Open Energy Information

    Open Energy Info (EERE)

    A. Climate Zone 1A is defined as Very Hot - Humid with IP Units 9000 < CDD50F and SI Units 5000 < CDD10C . The following places are categorized as class 1A climate zones:...

  6. Microsoft Word - 4CO 11 1a

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    OUTDOOR PV PERFORMANCE EVALUATION OF THREE DIFFERENT MODELS: SINGLE-DIODE, SAPM AND LOSS FACTOR MODEL Joshua S. Stein 1a , Juergen Sutterlueti 2 , Steve Ransome 3 , Clifford W. Hansen 1b , Bruce H. King 1c 1a (Corresponding Author) Sandia National Laboratories, P.O. Box 5800 MS 1033, Albuquerque, NM 87185 USA. tel: (505)-845-0936, fax: (505)-844-2890, email: jsstein@sandia.gov 1b tel: (505) 284-1643, cwhanse@sandia.gov 1c tel: (505) 284-6571, bhking@sandia.gov 2 TEL Solar, Haupstrasse 1a, 9477

  7. Induction of cytochromes P450 1A1 and 1A2 by tanshinones in human...

    Office of Scientific and Technical Information (OSTI)

    human HepG2 hepatoma cell line Citation Details In-Document Search Title: Induction of cytochromes P450 1A1 and 1A2 by tanshinones in human HepG2 hepatoma cell line Diterpenoid ...

  8. Houston, Texas: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    Power Technology Inc Power Tube Inc RRI Energy Inc formerly known as Reliant Energy Inc Red River Biodiesel Ltd Reliant Energy Ridge Energy Storage and Grid Services LP Simbol...

  9. Houston Zero Emission Delivery Vehicle Deployment Project

    Broader source: Energy.gov [DOE]

    2013 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting

  10. Houston, Texas: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    Inc Power Tube Inc RRI Energy Inc formerly known as Reliant Energy Inc Red River Biodiesel Ltd Reliant Energy Ridge Energy Storage and Grid Services LP Simbol Mining Corp...

  11. Houston Gasoline and Diesel Retail Prices

    U.S. Energy Information Administration (EIA) Indexed Site

    040 2.060 2.021 2.059 2.100 2.109 2000-2016 All Grades - Reformulated Areas 2.040 2.060 2.021 2.059 2.100 2.109 2000-2016 Regular 1.911 1.930 1.891 1.931 1.968 1.977 2000-2016 Reformulated Areas 1.911 1.930 1.891 1.931 1.968 1.977 2000-2016 Midgrade 2.200 2.221 2.176 2.213 2.254 2.265 2000-2016 Reformulated Areas 2.200 2.221 2.176 2.213 2.254 2.265 2000-2016 Premium 2.467 2.489 2.456 2.487 2.540 2.550 2000-2016 Reformulated Areas 2.467 2.489 2.456 2.487 2.540 2.550

  12. DOE O 442.1A

    Broader source: Energy.gov (indexed) [DOE]

    A 6-6-01 THIS PAGE IS TO REMAIN WITH DOE O 442.1A THIS PAGE TRANSMITS AN ADMINISTRATIVE CHANGE TO DOE O 442.1, DEPARTMENT OF ENERGY EMPLOYEE CONCERNS PROGRAM, DATED 2-1-99. THIS...

  13. EPA Mobile Source Enforcement Memo 1A

    Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

    UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 OFFICE OF ENFORCEMENT AND COMPLIANCE ASSURANCE September 4, 1997 Addendum to Mobile Source Enforcement Memorandum 1A SUBJECT: Tampering Enforcement Policy for Alternative Fuel Aftermarket Conversions A. Purpose The purpose of this document is to clarify and revise the U.S. Environmental Protection Agency's (EPA's) "tampering" enforcement policy for motor vehicles and motor vehicle engines originally designed to

  14. ARM - VAP Product - lblch1a

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    a Documentation Data Management Facility Plots (Quick Looks) Citation DOI: 10.5439/1095318 [ What is this? ] Generate Citation ARM Data Discovery Browse Data Comments? We would love to hear from you! Send us a note below or call us at 1-888-ARM-DATA. Send VAP Output : LBLCH1A AERI: LBLRTM, 520-830 wavenumbers Active Dates 1993.12.08 - 1994.04.11

  15. H2A Delivery Models and Results

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Delivery Models and Results Marianne Mintz, Jerry Gillette, Amgad Elgowainy, Argonne National Laboratory Matt Ringer, National Renewable Energy Laboratory Daryl Brown, Pacific Northwest National Laboratory Tracy Carole, Energetics Mark Paster, DOE DOE and FreedomCAR & Fuel Partnership Hydrogen Delivery and On-Board Storage Analysis Workshop January 25, 2006 H2A Delivery Presentation Outline * DOE Delivery Goals * H2A Project - Background - Approach & key assumptions * Delivery Scenarios

  16. Pump-1-A Wholesale Power Rate Schedule | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    1-A Wholesale Power Rate Schedule Pump-1-A Wholesale Power Rate Schedule Area: Carters & ... Document Available for Download PDF icon Pump-1-A Rate Schedule More Documents & ...

  17. EIA Energy Efficiency-Table 1a. Table 1a. Consumption of Site...

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    a Page Last Modified: May 2010 Table 1a. Consumption of Energy (Site Energy) for All Purposes (First Use) for Selected Industries, 1998, 2002, and 2006 (Trillion Btu) MECS Survey...

  18. Bison Wind Farm 1A | Open Energy Information

    Open Energy Info (EERE)

    Bison Wind Farm 1A Jump to: navigation, search Name Bison Wind Farm 1A Facility Bison Wind 1A Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service...

  19. Database for Regional Geology, Phase 1- A Tool for informing...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Database for Regional Geology, Phase 1- A Tool for informing Regional Evaluations of Alternative Geologic Media and Decision Making Database for Regional Geology, Phase 1- A Tool ...

  20. Cytochrome P450 2A5 and bilirubin: Mechanisms of gene regulation and cytoprotection

    SciTech Connect (OSTI)

    Kim, Sangsoo Daniel; Antenos, Monica; Squires, E. James; Kirby, Gordon M.

    2013-07-15

    Bilirubin (BR) has recently been identified as the first endogenous substrate for cytochrome P450 2A5 (CYP2A5) and it has been suggested that CYP2A5 plays a major role in BR clearance as an alternative mechanism to BR conjugation by uridine-diphosphate glucuronyltransferase 1A1. This study investigated the mechanisms of Cyp2a5 gene regulation by BR and the cytoprotective role of CYP2A5 in BR hepatotoxicity. BR induced CYP2A5 expression at the mRNA and protein levels in a dose-dependent manner in primary mouse hepatocytes. BR treatment also caused nuclear translocation of Nuclear factor-E2 p45-related factor 2 (Nrf2) in hepatocytes. In reporter assays, BR treatment of primary hepatocytes transfected with a Cyp2a5 promoter-luciferase reporter construct resulted in a 2-fold induction of Cyp2a5 reporter activity. Furthermore, cotransfection of the hepatocytes with a Nrf2 expression vector without BR treatment resulted in an increase in Cyp2a5 reporter activity of approximately 2-fold and BR treatment of Nrf2 cotransfectants further increased reporter activity by 4-fold. In addition, site-directed mutation of the ARE in the reporter construct completely abolished both the BR- and Nrf2-mediated increases in reporter activity. The cytoprotective role of CYP2A5 against BR-mediated apoptosis was also examined in Hepa 1–6 cells that lack endogenous CYP2A5. Transient overexpression of CYP2A5 partially blocked BR-induced caspase-3 cleavage in Hepa 1–6 cells. Furthermore, in vitro degradation of BR was increased by microsomes from Hepa 1–6 cells overexpressing CYP2A5 compared to control cells transfected with an empty vector. Collectively, these results suggest that Nrf2-mediated CYP2A5 transactivation in response to BR may provide an additional mechanism for adaptive cytoprotection against BR hepatotoxicity. - Highlights: • The mechanism of Cyp2a5 gene regulation by BR was investigated. • The cytoprotective role of CYP2A5 in BR hepatotoxicity was determined. • BR

  1. Table 2a. Electricity Consumption and Electricity Intensities...

    U.S. Energy Information Administration (EIA) Indexed Site

    Administration Home Page Home > Commercial Buildings Home > Sq Ft Tables > Table 2a. Electricity Consumption per Sq Ft Table 2a. Electricity Consumption and Electricity...

  2. Replacement-2-A Wholesale Power Rate Schedule | Department of...

    Office of Environmental Management (EM)

    2-A Wholesale Power Rate Schedule Replacement-2-A Wholesale Power Rate Schedule Area: Replacement Energy System: Kerr-Philpott This rate schedule shall be available to public...

  3. Hydrogen Analysis (H2A) | Open Energy Information

    Open Energy Info (EERE)

    Analysis (H2A) Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Hydrogen Analysis (H2A) AgencyCompany Organization: National Renewable Energy Laboratory Sector: Energy...

  4. DOE M 481.1-1A | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    1.1-1A DOE M 481.1-1A Reimbursable Work for Non-Federal Sponsors Process Manual DOE M 481.1-1A (113.59 KB) More Documents & Publications U.S. Department of Energy Order Doing Business with the National Labs EXHIBIT A: CRADA, WFO, PUA and NPUA Comparison Table, with suggested changes

  5. Cancellation of DOE G 440.2B-1A

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-02-15

    Cancels DOE G 440.2B-1A, Implementation Guide - Performance Indicators (Metrics) for Use with Doe O 440.2B, Aviation Management and Safety.

  6. Sample Business Plan Framework 1: A program seeking to continue...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Sample Business Plan Framework 1: A program seeking to continue operations in the ... U.S. Department of Energy Better Buildings Neighborhood Program: Sample Business Plan ...

  7. The Biological Implications of the PP2A Crystal Structure

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The Biological Implications of the PP2A Crystal Structure The Biological Implications of the PP2A Crystal Structure Print Wednesday, 30 January 2008 00:00 Phosphatases, enzymes that remove a phosphate group from amino-acid substrates, can be subdivided according to their substrate specificity. Myriad evidence has demonstrated that protein phosphatase 2A (PP2A), a family of serine/threonine-specific (Ser/Thr) phosphatases, regulates many, if not most, aspects of cellular activities and is a

  8. DOE H2A Analysis | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Systems Analysis » DOE H2A Analysis DOE H2A Analysis Realistic assumptions, both market- and technology-based, are critical to an accurate analytical study. DOE's H2A Analysis Group develops the building blocks and frameworks needed to conduct rigorous and consistent analyses of a wide range of hydrogen technologies. Established in FY 2003, H2A (which stands for hydrogen analysis) brings together the analysis expertise in the hydrogen community, drawing from industry, academia, and DOE's

  9. RRC Form H-1A | Open Energy Information

    Open Energy Info (EERE)

    A Jump to: navigation, search OpenEI Reference LibraryAdd to library Reference: RRC Form H-1A Published RRC, Date Not Provided DOI Not Provided Check for DOI availability: http:...

  10. The Biological Implications of the PP2A Crystal Structure

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The Biological Implications of the PP2A Crystal Structure Print Phosphatases, enzymes that remove a phosphate group from amino-acid substrates, can be subdivided according to their substrate specificity. Myriad evidence has demonstrated that protein phosphatase 2A (PP2A), a family of serine/threonine-specific (Ser/Thr) phosphatases, regulates many, if not most, aspects of cellular activities and is a critical tumor suppressor. A team at the University of Washington recently determined the first

  11. The Biological Implications of the PP2A Crystal Structure

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The Biological Implications of the PP2A Crystal Structure Print Phosphatases, enzymes that remove a phosphate group from amino-acid substrates, can be subdivided according to their substrate specificity. Myriad evidence has demonstrated that protein phosphatase 2A (PP2A), a family of serine/threonine-specific (Ser/Thr) phosphatases, regulates many, if not most, aspects of cellular activities and is a critical tumor suppressor. A team at the University of Washington recently determined the first

  12. The Biological Implications of the PP2A Crystal Structure

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The Biological Implications of the PP2A Crystal Structure Print Phosphatases, enzymes that remove a phosphate group from amino-acid substrates, can be subdivided according to their substrate specificity. Myriad evidence has demonstrated that protein phosphatase 2A (PP2A), a family of serine/threonine-specific (Ser/Thr) phosphatases, regulates many, if not most, aspects of cellular activities and is a critical tumor suppressor. A team at the University of Washington recently determined the first

  13. The Biological Implications of the PP2A Crystal Structure

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The Biological Implications of the PP2A Crystal Structure Print Phosphatases, enzymes that remove a phosphate group from amino-acid substrates, can be subdivided according to their substrate specificity. Myriad evidence has demonstrated that protein phosphatase 2A (PP2A), a family of serine/threonine-specific (Ser/Thr) phosphatases, regulates many, if not most, aspects of cellular activities and is a critical tumor suppressor. A team at the University of Washington recently determined the first

  14. The Biological Implications of the PP2A Crystal Structure

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Their structure provides a foundation for understanding PP2A regulation, satisfactory ... known as enzymes is a fundamental mechanism for the regulation of cellular activities. ...

  15. H2A Delivery Components Model and Analysis

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    assumes MACRS depreciation - Replacement capital includes for some components H2A Delivery ... Financial Analysis DirectIndirect Capital Costs Component Capital Costs Component ...

  16. H2A Delivery: Forecourt Compression & Storage Optimization (Part...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Delivery: Forecourt Compression & Storage Optimization (Part II) H2A Delivery: Forecourt Compression & Storage Optimization (Part II) Presentation by Matthew Hooks of TIAX at the...

  17. H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    A Hydrogen Delivery Infrastructure Analysis Models and Conventional Pathway Options Analysis Results - Interim Report H2A Hydrogen Delivery Infrastructure Analysis Models and ...

  18. Hydrogen Analysis (H2A) Production Component Model

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    selling cost given a specified after-tax internal rate of return. Key Attributes & Strengths Part of suite of H2A Models (Production, Delivery Components, Delivery Scenario). ...

  19. A polymorphism in metallothionein 1A (MT1A) is associated with cadmium-related excretion of urinary beta 2‐microglobulin

    SciTech Connect (OSTI)

    Lei, Lijian; Chang, Xiuli; Rentschler, Gerda; Tian, Liting; Zhu, Guoying; Chen, Xiao; Jin, Taiyi; Broberg, Karin

    2012-12-15

    Objectives: Cadmium (Cd) toxicity of the kidney varies between individuals despite similar exposure levels. In humans Cd is mainly bound to metallothioneins (MT), which scavenge its toxic effects. Here we analyzed whether polymorphisms in MT genes MT1A and MT2A influence Cd-related kidney damage. Methods: In a cross-sectional study N = 512 volunteers were selected from three areas in South-Eastern China, which to varying degree were Cd-polluted from a smelter (control area [median Cd in urine U-Cd = 2.67 μg/L], moderately [U-Cd = 4.23 μg/L] and highly [U-Cd = 9.13 μg/L] polluted areas). U-Cd and blood Cd (B-Cd) concentrations were measured by graphite-furnace atomic absorption spectrometry. MT1A rs11076161 (G/A), MT2A rs10636 (G/C) and MT2A rs28366003 (A/G) were determined by Taqman assays; urinary N-Acetyl-beta-(D)-Glucosaminidase (UNAG) by spectrometry, and urinary β2-microglobulin (UB2M) by ELISA. Results: Higher B-Cd (natural log-transformed) with increasing number of MT1A rs11076161 A-alleles was found in the highly polluted group (p-value trend = 0.033; all p-values adjusted for age, sex, and smoking). In a linear model a significant interaction between rs11076161 genotype and B-Cd was found for UNAG (p = 0.001) and UB2M concentrations (p = 0.001). Carriers of the rs11076161 AA genotype showed steeper slopes for the associations between Cd in blood and natural log-transformed UB2M (β = 1.2, 95% CI 0.72–1.6) compared to GG carriers (β = 0.30, 95% CI 0.15–0.45). Also for UNAG (natural log-transformed) carriers of the AA genotype had steeper slopes (β = 0.55, 95% CI 0.27–0.84) compared to GG carriers (β = 0.018, 95% CI − 0.79–0.11). Conclusions: MT1A rs11076161 was associated with B-Cd concentrations and Cd-induced kidney toxicity at high exposure levels. -- Highlights: ► Cadmium is toxic to the kidney but the susceptibility differs between individuals. ► The toxic effect of cadmium is scavenged by metallothioneins. ► A common variant of

  20. DOE-O-1300.2A | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    O-1300.2A DOE-O-1300.2A September 04, 1996 DOE Technical Standards Program Replaced by DOE-0-252.1-98 & DOE-G-252.1-1 The principle function of this Order is to establish a ...

  1. Cytochrome P450 2A13 enhances the sensitivity of human bronchial epithelial cells to aflatoxin B1-induced DNA damage

    SciTech Connect (OSTI)

    Yang, Xuejiao; Zhang, Zhan; Wang, Xichen; Wang, Yun; Zhang, Xiaoming; Lu, Huiyuan; Wang, Shou-Lin

    2013-07-15

    Cytochrome P450 2A13 (CYP2A13) mainly expresses in human respiratory system and mediates the metabolic activation of aflatoxin B1 (AFB1). Our previous study suggested that CYP2A13 could increase the cytotoxic and apoptotic effects of AFB1 in immortalized human bronchial epithelial cells (BEAS-2B). However, the role of CYP2A13 in AFB1-induced DNA damage is unclear. Using BEAS-2B cells that stably express CYP2A13 (B-2A13), CYP1A2 (B-1A2), and CYP2A6 (B-2A6), we compared their effects in AFB1-induced DNA adducts, DNA damage, and cell cycle changes. BEAS-2B cells that were transfected with vector (B-vector) were used as a control. The results showed that AFB1 (580 nM) dose- and time-dependently induced DNA damage in B-2A13 cells. AFB1 at 10 and 80 nM significantly augmented this effect in B-2A13 and B-1A2 cells, respectively. B-2A6 cells showed no obvious DNA damage, similar to B-vector cells and the vehicle control. Similarly, compared with B-vector, B-1A2 or B-2A6 cells, B-2A13 cells showed more sensitivity in AFB1-induced ?H2AX expression, DNA adduct 8-hydroxy-deoxyguanosine formation, and S-phase cell-cycle arrest. Furthermore, AFB1 activated the proteins related to DNA damage responses, such as ATM, ATR, Chk2, p53, BRCA1, and H2AX, rather than the proteins related to DNA repair. These effects could be almost completely inhibited by 100 ?M nicotine (a substrate of CYP2A13) or 1 ?M 8-methoxypsoralen (8-MOP; an inhibitor of CYP enzyme). Collectively, these findings suggest that CYP2A13 plays an important role in low-concentration AFB1-induced DNA damage, possibly linking environmental airborne AFB1 to genetic injury in human respiratory system. - Highlights: CYP2A13 plays a critical role in low concentration of AFB1-induced DNA damage. B-2A13 cells were more sensitive to AFB1 than B-1A2 cells and B-2A6 cells. AFB1 dose- and time-dependently induced DNA damage in B-2A13 cells AFB1-induced DNA adducts and damage can be inhibited by nicotine and 8-MOP.

  2. Clean Cities: Houston-Galveston Clean Cities coalition

    Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

    of AFV-based petroleum savings. Annual greenhouse gas emissions avoided: 26,309 tons of CO2 See the GHG by AFV tab for a breakdown of AFV-based greenhouse gas savings. Annual...

  3. DOE Zero Energy Ready Home: Durable Energy Builders, Houston...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    New Paltz, NY Building America Zero Energy Ready Home Case Study: Southeast Volusia Habitat for Humanity, Edgewater, Florida DOE Zero Energy Ready Home Case Study: Shore Road ...

  4. Energy Secretary Moniz Highlights Sandia Efforts during Recent Houston

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Vulnerabilities to Climate Change | Department of Energy Releases Report on America's Regional Vulnerabilities to Climate Change Energy Secretary Ernest Moniz Releases Report on America's Regional Vulnerabilities to Climate Change October 9, 2015 - 2:44pm Addthis NEWS MEDIA CONTACT (202) 586-4940 DOENews@hq.doe.gov Report examines U.S. energy system's climate threats and solutions; Moniz joins Los Angeles Mayor Eric Garcetti at event highlighting resiliency solutions LOS ANGELES -- While

  5. City of Houston- Green Building Policy for Municipal Buildings

    Broader source: Energy.gov [DOE]

    As of April 2015, a total of 23 city projects were LEED certified, seven were pursing LEED certification, and 6 were designed to LEED standards but not pursing certification.

  6. Smart Meters Offer 'Instant Gratification;' Help Houston Homeowners

    Broader source: Energy.gov (indexed) [DOE]

    Department of Energy Workshop Proceedings Smart Manufacturing Industry Day: Workshop Proceedings (801.67 KB) Final Agenda (116.53 KB) NNMI Industry Day: Smart Manufacturing AMO Overview, Mark Johnson, Director, DOE Advanced Manufacturing Office (3.74 MB) Smart Manufacturing Innovation Institute: Overview, Goals and Activities, Isaac Chan, Program Manager, R&D, DOE Advanced Manufacturing Office (1.03 MB) Working with DOE on Clean Energy Manufacturing Innovation Institutes, Kristen

  7. Albany, OR * Fairbanks, AK * Morgantown, WV * Pittsburgh, PA * Houston, TX

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NETL R&D Tackles Technological Challenges of the Williston Basin's Bakken Formation Recent development of the Bakken Formation in the Williston Basin of western North Dakota and eastern Montana is a good example of persistent analysis of geologic data and adaptation of new completion technologies overcoming the challenges posed by unconventional reservoirs. However, as with most unconventional plays, as Bakken development continues, questions regarding exactly how to refine newly applied

  8. Matt Schatzman € Houston € 22 October 2007

    U.S. Energy Information Administration (EIA) Indexed Site

    ... Belgium Japan France Italy Mexico Norway* South Korea Spain Taiwan Turkey UAE US UK India ... Jan Mar May Jul Sep Nov Other Mexico (east) UK EU Main China India Taiwan S Korea Japan ...

  9. Secretary Chu in Houston Today | Department of Energy

    Office of Environmental Management (EM)

    and continue his efforts as part of the Administration-wide ongoing oil spill response. ... Visit the Department of Energy Actions on BP Oil Spill web page for more information on ...

  10. DOE Zero Energy Ready Home: Durable Energy Builders, Houston, Texas

    Office of Energy Efficiency and Renewable Energy (EERE)

    This DOE Zero Energy Ready Home features super-insulated roof, 11,500 gallon rainwater cistern to supply most of the home’s drinking water, hurricane-proof roof, and triple-pane windows.

  11. Houston Visit Highlights People and Programs Helping the Office...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    (L to R - Chrissy Borskey, GE Distributed Power; Tracey Sledge, GE O&G; Paula Gant, DOE; Paul Doucette, GE O&G; Jeanette Patel, GE Canada; and Hannah Kaplan, GE Distributed Power....

  12. H2A Delivery Scenario Model and Analyses

    Broader source: Energy.gov [DOE]

    Presentation on H2A Delivery Scenario Model and Analysis for the DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project Review Meeting held February 8-9, 2005 at Argonne National Laboratory

  13. H2A Delivery Components Model and Analysis

    Broader source: Energy.gov [DOE]

    Presentation on H2A Delivery Components Model and Analysis for the DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project Review Meeting held February 8-9, 2005 at Argonne National Laboratory

  14. Rf2a and rf2b transcription factors

    DOE Patents [OSTI]

    Beachy, Roger N.; Petruccelli, Silvana; Dai, Shunhong

    2007-10-02

    A method of activating the rice tungro bacilliform virus (RTBV) promoter in vivo is disclosed. The RTBV promoter is activated by exposure to at least one protein selected from the group consisting of Rf2a and Rf2b.

  15. The Biological Implications of the PP2A Crystal Structure

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The Biological Implications of the PP2A Crystal Structure Print Phosphatases, enzymes that remove a phosphate group from amino-acid substrates, can be subdivided according to their...

  16. The Biological Implications of the PP2A Crystal Structure

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    susceptibility to pathogen infections. To shed light on the details of how PP2A works, Cho and Xu have determined the first crystal structure of the enzyme. Their structure...

  17. H2A Delivery Models and Results | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Models and Results H2A Delivery Models and Results Presentation on hydrogen analysis delivery models and results prepared for DOE January 25 workshop. wkshp_storage_mintz.pdf (1.89 MB) More Documents & Publications Analysis of a Cluster Strategy for Near Term Hydrogen Infrastructure Rollout in Southern California H2A Delivery Scenario Model and Analyses Hydrogen Supply: Cost Estimate for Hydrogen Pathways-Scoping Analysis. January 22, 2002-July 22, 2002

  18. H2A Delivery: Miscellaneous Cost and H2 Losses

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Miscellaneous Costs and H2 Losses Hydrogen Delivery Analysis Meeting May 8-9, 2006 Matt Ringer National Renewable Energy Laboratory H2A Delivery Presentation Outline * Direct and Indirect Costs * Operating and Maintenance Costs * Labor Costs and Scaling Factor * Component Hydrogen Losses H2A Delivery Direct and Indirect Costs * Currently posted model includes site preparation, engineering and design, project contingency, one-time licensing fees and permitting - Factor of 1.225 above installed

  19. H2A Hydrogen Production Analysis Tool (Presentation)

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Hydrogen Production Analysis Tool For BILIWG and PURIWG Preliminary Cost Analyses Darlene Steward, NREL H2A Overview * Discounted cash flow analysis tool for production of hydrogen from various feedstocks - Inputs are; * Capital costs * Operating costs * Financial parameters - Outputs are cost of hydrogen ($/kg) and yearly breakdown of costs and revenue H2A Hydrogen Analysis Tool - Structure * Excel spreadsheet based * Spreadsheet tabs for: - Information about the process - Feedstock prices and

  20. Certification for DOE O 542.2A, Unsolicited Proposals

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2006-12-28

    DOE Order 542.2A has been reviewed by my organization and is deemed to be in compliance with related Departmental Directives, Secretarial Delegation, organizational structure, budget guidelines, rules, regulations, standards, OMS guidance, relevant memorandums of understanding and public laws.

  1. DOE F 2050.2A | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    A DOE F 2050.2A Form documents that joint inventors agree to sell their invention and all documentation to the U.S. Government for the sum of one dollar. PATENT ASSIGNMENT FORM (28.34 KB) More Documents & Publications DOE F 2050.2 DOE F 2000.4 Department of Energy Record of Invention Form

  2. PEM Electrolysis H2A Production Case Study Documentation

    SciTech Connect (OSTI)

    James, Brian; Colella, Whitney; Moton, Jennie; Saur, G.; Ramsden, T.

    2013-12-31

    This report documents the development of four DOE Hydrogen Analysis (H2A) case studies for polymer electrolyte membrane (PEM) electrolysis. The four cases characterize PEM electrolyzer technology for two hydrogen production plant sizes (Forecourt and Central) and for two technology development time horizons (Current and Future).

  3. H2A Production Model, Version 2 User Guide

    SciTech Connect (OSTI)

    Steward, D.; Ramsden, T.; Zuboy, J.

    2008-09-01

    The H2A Production Model analyzes the technical and economic aspects of central and forecourt hydrogen production technologies. Using a standard discounted cash flow rate of return methodology, it determines the minimum hydrogen selling price, including a specified after-tax internal rate of return from the production technology. Users have the option of accepting default technology input values--such as capital costs, operating costs, and capacity factor--from established H2A production technology cases or entering custom values. Users can also modify the model's financial inputs. This new version of the H2A Production Model features enhanced usability and functionality. Input fields are consolidated and simplified. New capabilities include performing sensitivity analyses and scaling analyses to various plant sizes. This User Guide helps users already familiar with the basic tenets of H2A hydrogen production cost analysis get started using the new version of the model. It introduces the basic elements of the model then describes the function and use of each of its worksheets.

  4. H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Pathway Options Analysis Results - Interim Report | Department of Energy Delivery Infrastructure Analysis Models and Conventional Pathway Options Analysis Results - Interim Report H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional Pathway Options Analysis Results - Interim Report An in-depth comparative analysis of promising infrastructure options for hydrogen delivery and distribution to refueling stations from central, semi-central, and distributed production facilities.

  5. Structure of Human Argonaute2: A Programmable Ribonuclease | Stanford

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Synchrotron Radiation Lightsource Human Argonaute2: A Programmable Ribonuclease Wednesday, July 31, 2013 Ribonucleases (RNases) are a class of enzymes that degrade ribonucleic acids (RNA) by catalyzing hydrolysis of the phosphodiester backbone. RNases are vital to many cellular processes ranging from messenger RNA (mRNA) decay to DNA replication. Most of these enzymes are relatively non-specific, catalyzing the degradation of RNA with very little sequence specificity. Argonaute proteins,

  6. combined_supplemental_hud_multifamily_weatherization_list_3-2A...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    3-2A.xls combinedsupplementalhudmultifamilyweatherizationlist3-2A.xls combinedsupplementalhudmultifamilyweatherizationlist3-2A.xls More Documents & Publications...

  7. Experimental Station 10-2a | Stanford Synchrotron Radiation Lightsource

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    a Beam line 10-2 is a wiggler end-station that splits time between the front hutch (BL10-2a), which is instrumented for X-ray absorption spectroscopy imaging, and the rear hutch (BL10-2b), which has a dedicated 6-circle diffractometer that is used for materials scattering. The front hutch utilizes a polycapillary focusing optic to provide a beam spot as small as ~10 microns. Samples as large as 300 x 600 mm can be measured in one image, but larger samples can also be accommodated. In addition,

  8. Attachment L-2a Relevant Corporate Experience Form

    National Nuclear Security Administration (NNSA)

    [Submit in Volume II, TAB 1] DE-SOL-0008449 Attachment L-2a Relevant Corporate Experience Form 1) Experience Submission Number: (Start with 1 and number consecutively) 2). Name and Address of Offeror or Team Member 3. Complete Name/Title of Contract and Location/Address of project/contract 3. Project Owner Name and Address 4. Contract Number and Type of Contract 5. Date of Contract Award 6. Date Work Commenced 7. Date Work Ended 8. Initial Contract Price/Cost and Fee 9. Final Amount

  9. WRAP 2A advanced conceptual design report comments

    SciTech Connect (OSTI)

    Lamberd, D.L.

    1994-10-04

    This report contains the compilation of the 393 comments that were submitted during the review of the Advanced Conceptual Design Report for the Waste Receiving and Processing Facility Module 2A. The report was prepared by Raytheon Engineers and Constructors, Inc. of Englewood, Colorado for the United States Department of Energy. The review was performed by a variety of organizations identified in the report. The comments were addressed first by the Westinghouse cognizant engineers and then by the Raytheon cognizant engineers, and incorporated into the final issue of the Advanced Conceptual Design Report.

  10. Microsoft Word - P450-2A6.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Highlight -November 2005 Figure 1. Stereo views of σ A -weighted 2|Fo|-|Fc| composite omit electron density maps contoured at 1σ and rendered within 1 Å of the heme and substrate for the P450 2A6 (a) coumarin or (b) methoxsalen complexes. Coumarin and methoxsalen are stabilized by hydrogen bonding with Asn297, which places the carbon atom to be oxidized 3.2 ± 0.13 Å (coumarin) or 3.8 ± 0.09 Å (methoxsalen) from the heme iron. The distances are shown as a red dotted line and the

  11. High Statistics Study of Nearby Type 1a Supernovae. QUEST Camera...

    Office of Scientific and Technical Information (OSTI)

    Statistics Study of Nearby Type 1a Supernovae. QUEST Camera Short Term Maintenance: Final Technical Report Baltay, Charles 79 ASTRONOMY AND ASTROPHYSICS Study of Type 1a Supernovae...

  12. Increased expression of bHLH transcription factor E2A (TCF3) in prostate cancer promotes proliferation and confers resistance to doxorubicin induced apoptosis

    SciTech Connect (OSTI)

    Patel, Divya; Chaudhary, Jaideep; Dept. of Biological Sciences, Clark Atlanta University, 223 James P. Brawley Dr. SW, Atlanta, GA 30314

    2012-05-25

    Highlights: Black-Right-Pointing-Pointer E2A, considered as a tumor suppressor is highly expressed in prostate cancer. Black-Right-Pointing-Pointer Silencing of E2A attenuates cell proliferation and promotes apoptosis. Black-Right-Pointing-Pointer E2A regulates c-myc, Id1, Id3 and CDKN1A expression. Black-Right-Pointing-Pointer Loss of E2A promotes doxorubicin dependent apoptosis in prostate cancer cells. Black-Right-Pointing-Pointer Results suggest that E2A acts as a tumor promoter at least in prostate cancer. -- Abstract: E2A (TCF3) is a multifunctional basic helix loop helix (bHLH), transcription factor. E2A regulates transcription of target genes by homo- or heterodimerization with cell specific bHLH proteins. In general, E2A promotes cell differentiation, acts as a negative regulator of cell proliferation in normal cells and cancer cell lines and is required for normal B-cell development. Given the diverse biological pathways regulated/influenced by E2A little is known about its expression in cancer. In this study we investigated the expression of E2A in prostate cancer. Unexpectedly, E2A immuno-histochemistry demonstrated increased E2A expression in prostate cancer as compared to normal prostate. Silencing of E2A in prostate cancer cells DU145 and PC3 led to a significant reduction in proliferation due to G1 arrest that was in part mediated by increased CDKN1A(p21) and decreased Id1, Id3 and c-myc. E2A silencing in prostate cancer cell lines also resulted in increased apoptosis due to increased mitochondrial permeability and caspase 3/7 activation. Moreover, silencing of E2A increased sensitivity to doxorubicin induced apoptosis. Based on our results, we propose that E2A could be an upstream regulator of Id1 and c-Myc which are highly expressed in prostate cancer. These results for the first time demonstrate that E2A could in fact acts as a tumor promoter at least in prostate cancer.

  13. Completion Report for Well ER-EC-2A

    SciTech Connect (OSTI)

    M. J. Townsend

    2002-03-01

    Well ER-EC-2A was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office, in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in January and February of 2000 as part of a hydrogeologic investigation program in the Pahute Mesa - Oasis Valley region just west of the Nevada Test Site. A 44.5-centimeter surface hole was drilled and cased off to a depth of 412.9 meters below the surface. The hole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 1,516.1 meters. One completion string with three isolated slotted intervals was installed in the well. A preliminary composite, static water level was measured at the depth of 228.0 meters, approximately two months after installation of the completion string. Detailed lithologic descriptions with preliminary stratigraphic assignments are included in this report. These are based on composite drill cuttings collected every 3 meters, and 81 sidewall samples taken at various depths below 212 meters, supplemented by geophysical log data. Detailed petrographic, chemical, and mineralogical studies of rock samples were conducted on 30 samples. The well was collared in rhyolite lava and penetrated Tertiary-age lava and tuff of the Volcanics of Fortymile Canyon and the Timber Mountain Group. The preliminary geologic interpretation of borehole data indicates that this well was drilled within the margins of the buried Rainier Mesa and Ammonia Tanks calderas, and that caldera collapse in this area was deeper than expected, resulting in a section of Volcanics of Fortymile Canyon (caldera-filling deposit) that is much thicker than expected.

  14. Appendices of DOE G 226.1-2A | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Appendices of DOE G 226.1-2A Appendices of DOE G 226.1-2A Below are the appendices to DOE G 226.1-2A Federal Line Management Oversight of Department of Energy Nuclear Facilities. ...

  15. DRAFT - DOE O 227.1A, Independent Oversight Program - DOE Directives,

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Delegations, and Requirements DRAFT - DOE O 227.1A, Independent Oversight Program by Website Administrator The Order prescribes requirements and responsibilities for DOE Independent Oversight Program. DOE O 227.1A, Independent Oversight Program

  16. XOP 2.1 - a new version of the x-ray optics software toolkit...

    Office of Scientific and Technical Information (OSTI)

    XOP 2.1 - a new version of the x-ray optics software toolkit. Citation Details In-Document Search Title: XOP 2.1 - a new version of the x-ray optics software toolkit. No abstract ...

  17. DOE O 580.1A Department of Energy Personal Property Management...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    DOE O 580.1A Department of Energy Personal Property Management Program The Department ... Directive on March 30, 2012. PF2012-33 DOE O 580.1A, DOE Personal Property Management ...

  18. Arabidopsis dynamin-related protein 1A polymers bind, but do not tubulate, liposomes

    SciTech Connect (OSTI)

    Backues, Steven K.; Bednarek, Sebastian Y.

    2010-03-19

    The Arabidopsis dynamin-related protein 1A (AtDRP1A) is involved in endocytosis and cell plate maturation in Arabidopsis. Unlike dynamin, AtDRP1A does not have any recognized membrane binding or protein-protein interaction domains. We report that GTPase active AtDRP1A purified from Escherichia coli as a fusion to maltose binding protein forms homopolymers visible by negative staining electron microscopy. These polymers interact with protein-free liposomes whose lipid composition mimics that of the inner leaflet of the Arabidopsis plasma membrane, suggesting that lipid-binding may play a role in AtDRP1A function. However, AtDRP1A polymers do not appear to assemble and disassemble in a dynamic fashion and do not have the ability to tubulate liposomes in vitro, suggesting that additional factors or modifications are necessary for AtDRP1A's in vivo function.

  19. Crystal structure of human dynein light chain Dnlc2A: Structural insights into the interaction with IC74

    SciTech Connect (OSTI)

    Liu Junfeng; Wang Zhanxin; Wang Xinquan; Tang Qun; An Xiaomin; Gui Lulu; Liang Dongcai . E-mail: dcliang@sun5.ibp.ac.cn

    2006-10-27

    The human light chain of the motor protein dynein, Dnlc2A, is also a novel TGF-{beta}-signaling component, which is altered with high frequency in epithelial ovarian cancer. It is an important mediator of dynein and the development of cancer, owing to its ability to bind to the dynein intermediate light chain (DIC) IC74 and to regulate TGF-{beta}-dependent transcriptional events. Here we report the 2.1-A crystal structure of Dnlc2A using single anomalous diffraction. The proteins form a homodimer in solution and interact mainly through the helix {alpha}{sub 2}, strand {beta}{sub 3}, and the loop following this strand in each protein to generate a 10-stranded {beta}-sheet core. The surface of the {beta}-sheet core is mainly positively charged and predicted (by software PPI-Pred) to be the site that interacts with other partners. At the same time, the residues 79-82, 88, and 90 of each molecule formed two holes in the core. Residue 89 of each molecule, which is crucial for the DIC binding function of Dnlc2A, is within the holes. On the basis of these observations, we propose that the homodimer is the structural and functional unit maintained by hydrogen bonding interactions and hydrophobic packing, and that the patch of the surface of the {beta}-sheet core is the main area of interaction with other partners. Furthermore, the two holes would be the key sites to interact with IC74.

  20. High Statistics Study of Nearby Type 1a Supernovae. QUEST Camera Short Term

    Office of Scientific and Technical Information (OSTI)

    Maintenance: Final Technical Report (Technical Report) | SciTech Connect High Statistics Study of Nearby Type 1a Supernovae. QUEST Camera Short Term Maintenance: Final Technical Report Citation Details In-Document Search Title: High Statistics Study of Nearby Type 1a Supernovae. QUEST Camera Short Term Maintenance: Final Technical Report The Quest Camera was installed at the Palomar Obervatory in California. The camera was used to carry out a survey of low redshift Type 1a supernovae.The

  1. DOE Order 442.1 A: Department of Energy Employee Concerns Program |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy 2.1 A: Department of Energy Employee Concerns Program DOE Order 442.1 A: Department of Energy Employee Concerns Program Stakeholders: DOE employees Scope: DOE Order 442.1A established the Department of Energy (DOE) Employee Concerns Program (ECP) that ensures employee concerns related to such issues as the environment, safety, health, and management of DOE and the National Nuclear Security Administration (NNSA) programs and facilities are addressed. Summary: The Employee

  2. LM Environmental Policy (PO 436.1a) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Environmental Policy (PO 436.1a) LM Environmental Policy (PO 436.1a) This policy reaffirms the Department of Energy (DOE), Office of Legacy Management's (LM) commitment to protect and respect the environment through our environment, safety, health and quality (ESH&Q) programs. LM Environmental Policy (PO 436.1a) (240.55 KB) More Documents & Publications LM Records and Information Management Transition Guidance (May 2016) EMS Description CX-013661

  3. EVMS Training Snippet: 3.1A Integrated Master Schedule (IMS)...

    Energy Savers [EERE]

    A Integrated Master Schedule (IMS) Initial Baseline Review EVMS Training Snippet: 3.1A Integrated Master Schedule (IMS) Initial Baseline Review This EVMS Training Snippet, ...

  4. Extension of DOE O 311.1A, Equal Employment Opportunity and Diversity Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2000-12-21

    This Notice extends DOE O 311.1A, Equal Employment Opportunity and Diversity Program, dated 12-30-96 until 12-30-01, unless sooner rescinded.

  5. Systematic Effects in Type-1a Supernovae Surveys from Host Galaxy...

    Office of Scientific and Technical Information (OSTI)

    Systematic Effects in Type-1a Supernovae Surveys from Host Galaxy Spectra Strauss, Michael A. Princeton University 79 ASTRONOMY AND ASTROPHYSICS Cosmology, supernovae, stellar...

  6. DOE O 580.1A Department of Energy Personal Property Management Program |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy 580.1A Department of Energy Personal Property Management Program DOE O 580.1A Department of Energy Personal Property Management Program The Department issued a Contractor Requirements Document (CRD) for the subject Directive on March 30, 2012. PF2012-33 DOE O 580.1A, DOE Personal Property Management Program (22.38 KB) More Documents & Publications Implementation of DOE Order 580.1A, Department of Energy Personal Property Management DOE O 551.1D Official Foreign

  7. Evaluation of the Cask Transportation Facility Modifications (CTFM) compliance to DOE order 6430.1A

    SciTech Connect (OSTI)

    ARD, K.E.

    1999-07-14

    This report was prepared to evaluate the compliance of Cask Transportation Facility Modifications (CTFM) to DOE Order 6430.1A.

  8. High Statistics Study of Nearby Type 1a Supernovae. QUEST Camera...

    Office of Scientific and Technical Information (OSTI)

    QUEST Camera Short Term Maintenance: Final Technical Report Citation Details In-Document Search Title: High Statistics Study of Nearby Type 1a Supernovae. QUEST Camera Short Term ...

  9. Critical Updates to the Hydrogen Analysis Production Model (H2A...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Critical Updates to the Hydrogen Analysis Production Model (H2A v3) Critical Updates to the Hydrogen Analysis Production Model (H2A v3) Presentation slides from the February 8, ...

  10. GIZ Sourcebook Module 2a: Land Use Planning and Urban Transport...

    Open Energy Info (EERE)

    GIZ Sourcebook Module 2a: Land Use Planning and Urban Transport (Espaol) Jump to: navigation, search Tool Summary LAUNCH TOOL Name: GIZ Sourcebook Module 2a: Land Use Planning...

  11. Negative feedback regulation of Homer 1a on norepinephrine-dependent cardiac hypertrophy

    SciTech Connect (OSTI)

    Chiarello, Carmelina; Bortoloso, Elena; Carpi, Andrea; Furlan, Sandra; Volpe, Pompeo

    2013-07-15

    Homers are scaffolding proteins that modulate diverse cell functions being able to assemble signalling complexes. In this study, the presence, sub-cellular distribution and function of Homer 1 was investigated. Homer 1a and Homer 1b/c are constitutively expressed in cardiac muscle of both mouse and rat and in HL-1 cells, a cardiac cell line. As judged by confocal immunofluorescence microscopy, Homer 1a displays sarcomeric and peri-nuclear localization. In cardiomyocytes and cultured HL-1 cells, the hypertrophic agonist norepinephrine (NE) induces α{sub 1}-adrenergic specific Homer 1a over-expression, with a two-to-three-fold increase within 1 h, and no up-regulation of Homer 1b/c, as judged by Western blot and qPCR. In HL-1 cells, plasmid-driven over-expression of Homer 1a partially antagonizes activation of ERK phosphorylation and ANF up-regulation, two well-established, early markers of hypertrophy. At the morphometric level, NE-induced increase of cell size is likewise and partially counteracted by exogenous Homer 1a. Under the same experimental conditions, Homer 1b/c does not have any effect on ANF up-regulation nor on cell hypertrophy. Thus, Homer 1a up-regulation is associated to early stages of cardiac hypertrophy and appears to play a negative feedback regulation on molecular transducers of hypertrophy. -- Highlights: • Homer 1a is constitutively expressed in cardiac tissue. • In HL-1 cells, norepinephrine activates signaling pathways leading to hypertrophy. • Homer 1a up-regulation is an early event of norepinephrine-induced hypertrophy. • Homer 1a plays a negative feedback regulation modulating pathological hypertrophy. • Over-expression of Homer 1a per se does not induce hypertrophy.

  12. Critical Updates to the Hydrogen Analysis Production Model (H2A v3) |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Critical Updates to the Hydrogen Analysis Production Model (H2A v3) Critical Updates to the Hydrogen Analysis Production Model (H2A v3) Presentation slides from the February 8, 2012, Fuel Cell Technologies Program webinar, "Critical Updates to the Hydrogen Analysis Production Model (H2A v3)." Critical Updates to the Hydrogen Analysis Production Model (H2A v3) Webinar Slides (1.24 MB) More Documents & Publications H2A Delivery Models and Results Hydrogen

  13. Critical Updates to the Hydrogen Analysis Production Model (H2A v3)

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Critical Updates to the Hydrogen Analysis Production Model (H2A v3) Darlene Steward NREL Thursday, February 9, 2012 3:00 PM - 4:30 PM EST Darlene.steward@nrel.gov (303) 275 3837 NREL/PR-5600-54276 NATIONAL RENEWABLE ENERGY LABORATORY Outline 2 Introduction - Sara Dillich Overview of the H2A Model H2A Version 3 Changes Case Study Walkthrough Resources 1 2 3 4 NATIONAL RENEWABLE ENERGY LABORATORY Outline 3 Introduction - Sara Dillich Overview of the H2A Model H2A Version 3 Changes Case Study

  14. Implementation of DOE Order 580.1A, Department of Energy Personal Property

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Management | Department of Energy DOE Order 580.1A, Department of Energy Personal Property Management Implementation of DOE Order 580.1A, Department of Energy Personal Property Management On March 30, 2012 The Department of Energy (DOE) published DOE Order 580.1A, DOE Property Management Program) as part of a deregulation initiative to replace obsolete parts to the DOE Property Management Regulation (DOE-PMR) codified at 41 CFR 109. The Order replaced obsolete and prescriptive provisions of

  15. Department of Energy (DOE) O 200.1A Information Technology Management...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    M 205.1-6 Media Sanitization Manual Department of Energy (DOE) O 200.1A Information Technology Management DOE M 205.1-6 Media Sanitization Manual PF2009-14.pdf (384.38 KB) More ...

  16. Syntaxin 1a Variants Lacking an N-peptide or Bearing the LE Mutation...

    Office of Scientific and Technical Information (OSTI)

    an N-peptide or Bearing the LE Mutation Bind to Munc18a in a Closed Conformation Citation Details In-Document Search Title: Syntaxin 1a Variants Lacking an N-peptide or Bearing ...

  17. Policy Flash 2014-40 Implementation of DOE O 580.1A, DOE Energy...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Policy Flash 2014-40 Implementation of DOE O 580.1A, DOE Energy Personal Property Management Questions may be referred to Scott Whiteford (202) 287-1563 or scott.whiteford@hq.doe.g...

  18. Systematic Effects in Type-1a Supernovae Surveys from Host Galaxy Spectra

    Office of Scientific and Technical Information (OSTI)

    (Technical Report) | SciTech Connect Systematic Effects in Type-1a Supernovae Surveys from Host Galaxy Spectra Citation Details In-Document Search Title: Systematic Effects in Type-1a Supernovae Surveys from Host Galaxy Spectra The physical relation between the properties of Type Ia supernovae and their host galaxies is investigated. Such supernovae are used to constrain the properties of dark energy, making it crucial to understand their physical properties and to check for systematic

  19. H2A Delivery: Miscellaneous Cost and H2 Losses | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Miscellaneous Cost and H2 Losses H2A Delivery: Miscellaneous Cost and H2 Losses Presentation by Matt Ringer of the National Renewable Energy Laboratory at the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007 deliv_analysis_ringer.pdf (327.03 KB) More Documents & Publications H2A Delivery Models and Results Hydrogen Delivery Analysis Models H2A Delivery Components Model and Analysis

  20. Buildings Energy Data Book: 3.10 Hotels/Motels

    Buildings Energy Data Book [EERE]

    5 Energy Benchmarks for Newly Constructed Large Hotels, by Selected City and End-Use (thousand Btu per square foot) Miami 1A Houston 2A Phoenix 2B Atlanta 3A Los Angeles 3B Las Vegas 3B San Francisco 3C Baltimore 4A Albuquerque 4B Seattle 4C Chicago 5A Boulder 5B Minneapolis 6A Helena 6B Duluth 7 Fairbanks 8 Note(s): Source(s): 60.9 13.2 76.3 8.4 Commercial building energy benchmarks are based off of the current stock of commercial buildings and reflect 2004 ASHRAE 90.1 Climate Zones. They are

  1. Buildings Energy Data Book: 3.10 Hotels/Motels

    Buildings Energy Data Book [EERE]

    6 Energy Benchmarks for Newly Constructed Small Hotels, by Selected City and End-Use (thousand Btu per square foot) Miami 1A Houston 2A Phoenix 2B Atlanta 3A Los Angeles 3B Las Vegas 3B San Francisco 3C Baltimore 4A Albuquerque 4B Seattle 4C Chicago 5A Boulder 5B Minneapolis 6A Helena 6B Duluth 7 Fairbanks 8 Note(s): Source(s): 36.6 2.7 12.0 3.9 Commercial building energy benchmarks are based off of the current stock of commercial buildings and reflect 2004 ASHRAE 90.1 Climate Zones. They are

  2. Buildings Energy Data Book: 3.6 Office Building Markets and Companies

    Buildings Energy Data Book [EERE]

    1 Energy Benchmarks for Newly Constructed Medium Office Buildings, by Selected City and End-Use (thousand Btu per square foot) Miami 1A Houston 2A Phoenix 2B Atlanta 3A Los Angeles 3B Las Vegas 3B San Francisco 3C Baltimore 4A Albuquerque 4B Seattle 4C Chicago 5A Boulder 5B Minneapolis 6A Helena 6B Duluth 7 Fairbanks 8 Note(s): Source(s): 38.6 0.9 0.8 1.1 Commercial building energy benchmarks are based off of the current stock of commercial buildings and reflect 2004 ASHRAE 90.1 Climate Zones.

  3. Buildings Energy Data Book: 3.6 Office Building Markets and Companies

    Buildings Energy Data Book [EERE]

    9 Energy Benchmarks for Newly Constructed Large Office Buildings, by Selected City and End-Use (thousand Btu per square foot) Miami 1A Houston 2A Phoenix 2B Atlanta 3A Los Angeles 3B Las Vegas 3B San Francisco 3C Baltimore 4A Albuquerque 4B Seattle 4C Chicago 5A Boulder 5B Minneapolis 6A Helena 6B Duluth 7 Fairbanks 8 Note(s): Source(s): 31.7 1.7 0.6 1.3 Commercial building energy benchmarks are based off of the current stock of commercial buildings and reflect 2004 ASHRAE 90.1 Climate Zones.

  4. Buildings Energy Data Book: 3.7 Retail Markets and Companies

    Buildings Energy Data Book [EERE]

    6 Energy Benchmarks for Newly Constructed Retail Buildings, by Selected City and End-Use (thousand Btu per square foot) IECC Climate Zone Miami 1A Houston 2A Phoenix 2B Atlanta 3A Los Angeles 3B Las Vegas 3B San Francisco 3C Baltimore 4A Albuquerque 4B Seattle 4C Chicago 5A Boulder 5B Minneapolis 6A Helena 6B Duluth 7 Fairbanks 8 Note(s): Source(s): 108.9 0.1 9.4 Commercial building energy benchmarks are based off of the current stock of commercial buildings and reflect 2004 ASHRAE 90.1 Climate

  5. Buildings Energy Data Book: 3.7 Retail Markets and Companies

    Buildings Energy Data Book [EERE]

    8 Energy Benchmarks for Newly Constructed Supermarkets, by Selected City and End-Use (thousand Btu per square foot) Miami 1A Houston 2A Phoenix 2B Atlanta 3A Los Angeles 3B Las Vegas 3B San Francisco 3C Baltimore 4A Albuquerque 4B Seattle 4C Chicago 5A Boulder 5B Minneapolis 6A Helena 6B Duluth 7 Fairbanks 8 Note(s): Source(s): 145.6 0.3 0.6 20.5 Commercial building energy benchmarks are based off of the current stock of commercial buildings and reflect 2004 ASHRAE 90.1 Climate Zones. They are

  6. Buildings Energy Data Book: 3.8 Hospitals and Medical Facilities

    Buildings Energy Data Book [EERE]

    4 Energy Benchmarks for Newly Constructed Hospitals, by Selected City and End-Use (thousand Btu per square foot) Miami 1A Houston 2A Phoenix 2B Atlanta 3A Los Angeles 3B Las Vegas 3B San Francisco 3C Baltimore 4A Albuquerque 4B Seattle 4C Chicago 5A Boulder 5B Minneapolis 6A Helena 6B Duluth 7 Fairbanks 8 Note(s): Source(s): 89.1 25.2 3.9 13.5 Commercial building energy benchmarks are based off of the current stock of commercial buildings and reflect 2004 ASHRAE 90.1 Climate Zones. They are

  7. Buildings Energy Data Book: 3.8 Hospitals and Medical Facilities

    Buildings Energy Data Book [EERE]

    6 Energy Benchmarks for Newly Constructed Outpatient Buildings, by Selected City and End-Use (thousand Btu per square foot) Miami 1A Houston 2A Phoenix 2B Atlanta 3A Los Angeles 3B Las Vegas 3B San Francisco 3C Baltimore 4A Albuquerque 4B Seattle 4C Chicago 5A Boulder 5B Minneapolis 6A Helena 6B Duluth 7 Fairbanks 8 Note(s): Source(s): 99.7 8.8 1.4 17.7 Commercial building energy benchmarks are based off of the current stock of commercial buildings and are designed to provide a consistent

  8. Buildings Energy Data Book: 3.9 Educational Facilities

    Buildings Energy Data Book [EERE]

    0 Energy Benchmarks for Newly Constructed Primary Schools, by Selected City and End-Use (thousand Btu per square foot) Miami 1A Houston 2A Phoenix 2B Atlanta 3A Los Angeles 3B Las Vegas 3B San Francisco 3C Baltimore 4A Albuquerque 4B Seattle 4C Chicago 5A Boulder 5B Minneapolis 6A Helena 6B Duluth 7 Fairbanks 8 Note(s): Source(s): 59.6 0.5 3.1 1.4 Commercial building energy benchmarks are based off of the current stock of commercial buildings and reflect 2004 ASHRAE 90.1 Climate Zones. They are

  9. Buildings Energy Data Book: 3.9 Educational Facilities

    Buildings Energy Data Book [EERE]

    2 Energy Benchmarks for Newly Constructed Secondary Schools, by Selected City and End-Use (thousand Btu per square foot) Miami 1A Houston 2A Phoenix 2B Atlanta 3A Los Angeles 3B Las Vegas 3B San Francisco 3C Baltimore 4A Albuquerque 4B Seattle 4C Chicago 5A Boulder 5B Minneapolis 6A Helena 6B Duluth 7 Fairbanks 8 Note(s): Source(s): 96.7 2.2 2.8 5.5 Commercial building energy benchmarks are based off of the current stock of commercial buildings and reflect 2004 ASHRAE 90.1 Climate Zones. They

  10. Fuel Cell Tri-Generation System Case Study using the H2A Stationary Model

    Broader source: Energy.gov [DOE]

    Overview of H2A stationary model concept, results, strategy for analysis, Federal incentives for fuel cells, and summary of next steps

  11. The Structural Basis for Tight Control of PP2A Methylation and...

    Office of Scientific and Technical Information (OSTI)

    Our studies suggested mechanisms of LCMT-1 in tight control of PP2A function, important ... Country of Publication: United States Language: ENGLISH Subject: 59 BASIC BIOLOGICAL ...

  12. Guidance for Filling Out a Detailed H2A Production Case Study

    Broader source: Energy.gov [DOE]

    Presentation slides from the EERE Fuel Cell Technologies Office webinar, Guidance for Filling Out a Detailed H2A Production Case Study, held July 9, 2013.

  13. Structure of the Ca[superscript 2+]-dependent PP2A heterotrimer...

    Office of Scientific and Technical Information (OSTI)

    SciTech Connect Search Results Journal Article: Structure of the Casuperscript 2+-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation Citation Details ...

  14. Metabolism of bilirubin by human cytochrome P450 2A6

    SciTech Connect (OSTI)

    Abu-Bakar, A'edah; Arthur, Dionne M.; Cooperative Research Centre for Contamination Assessment and Remediation of the Environment, Adelaide ; Wikman, Anna S.; Department of Pharmaceutical Biosciences, Uppsala University, SE-75123 Uppsala ; Rahnasto, Minna; Juvonen, Risto O.; Vepslinen, Jouko; Raunio, Hannu; Ng, Jack C.; Cooperative Research Centre for Contamination Assessment and Remediation of the Environment, Adelaide ; Lang, Matti A.

    2012-05-15

    The mouse cytochrome P450 (CYP) 2A5 has recently been shown to function as hepatic Bilirubin Oxidase (Abu-Bakar, A., et al., 2011. Toxicol. Appl. Pharmacol. 257, 1422). To date, no information is available on human CYP isoforms involvement in bilirubin metabolism. In this paper we provide novel evidence for human CYP2A6 metabolising the tetrapyrrole bilirubin. Incubation of bilirubin with recombinant yeast microsomes expressing the CYP2A6 showed that bilirubin inhibited CYP2A6-dependent coumarin 7-hydroxylase activity to almost 100% with an estimated K{sub i} of 2.23 ?M. Metabolite screening by a high-performance liquid chromatography/electrospray ionisation mass spectrometry indicated that CYP2A6 oxidised bilirubin to biliverdin and to three other smaller products with m/z values of 301, 315 and 333. Molecular docking analyses indicated that bilirubin and its positively charged intermediate interacted with key amino acid residues at the enzyme's active site. They were stabilised at the site in a conformation favouring biliverdin formation. By contrast, the end product, biliverdin was less fitting to the active site with the critical central methylene bridge distanced from the CYP2A6 haem iron facilitating its release. Furthermore, bilirubin treatment of HepG2 cells increased the CYP2A6 protein and activity levels with no effect on the corresponding mRNA. Co-treatment with cycloheximide (CHX), a protein synthesis inhibitor, resulted in increased half-life of the CYP2A6 compared to cells treated only with CHX. Collectively, the observations indicate that the CYP2A6 may function as human Bilirubin Oxidase where bilirubin is potentially a substrate and a regulator of the enzyme. -- Highlights: ? Human CYP2A6 interacts with bilirubin with a high affinity. ? Bilirubin docking to the CYP2A6 active site is more stable than biliverdin docking. ? Recombinant CYP2A6 microsomes metabolised bilirubin to biliverdin. ? Bilirubin increased the hepatic CYP2A6 protein and

  15. Supplemental Reactor Physics Calculations and Analysis of ELF Mk 1A Fuel

    SciTech Connect (OSTI)

    Michael A. Pope

    2014-10-01

    These calculations supplement previous the reactor physics work evaluating the Enhanced Low Enriched Uranium (LEU) Fuel (ELF) Mk 1A element. This includes various additional comparisons between the current Highly Enriched Uranium (HEU) and LEU along with further characterization of the performance of the ELF fuel. The excess reactivity to be held down at BOC for ELF Mk 1A fuel is estimated to be approximately $2.75 greater than with HEU for a typical cycle. This is a combined effect of the absence of burnable poison in the ELF fuel and the reduced neck shim worth in LEU fuel compared to HEU. Burnable poison rods were conceptualized for use in the small B positions containing Gd2O3 absorber. These were shown to provide $2.37 of negative reactivity at BOC and to burn out in less than half of a cycle. The worth of OSCCs is approximately the same between HEU and ELF Mk 1A (LEU) fuels in the representative loading evaluated. This was evaluated by rotating all banks simultaneously. The safety rod worth is relatively unchanged between HEU and ELF Mk 1A (LEU) fuels in the representative loading evaluated. However, this should be reevaluated with different loadings. Neutron flux, both total and fast (>1 MeV), is either the same or reduced upon changing from HEU to ELF Mk 1A (LEU) fuels in the representative loading evaluated. This is consistent with the well-established trend of lower neutron fluxes for a given power in LEU than HEU.The IPT loop void reactivity is approximately the same or less positive with ELF Mk 1A (LEU) fuel than HEU in the representative loading evaluated.

  16. NETL F 142.1-1A, Request for Unclassified Foreign National Access (Short Form)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    142.1-1A Revised: 10/27/2014 Reviewed: 10/27/2014 (Previous Editions Obsolete) U.S. DEPARTMENT OF ENERGY REQUEST FOR UNCLASSIFIED FOREIGN NATIONAL ACCESS (SHORT FORM) COVER SHEET FOR NETL FORM 142.1-1A Privacy Act Notice Authority: Collection of the information is authorized pursuant to Section 145 of the Atomic Energy Act of 1954, as amended (Public Law 83-703, 42 U.S.C. 2165); and The Privacy Act of 1974, as amended (Public Law 93-579, 5 U.S.C. § 552a). Purpose: The primary purpose of the

  17. Compositions and methods related to serotonin 5-HT1A receptors

    DOE Patents [OSTI]

    Mukherjee, Jogeshwar; Saigal, Neil; Saigal, legal representative, Harsh

    2012-09-25

    Contemplated substituted arylpiperazinyl compounds, and most preferably 18F-Mefway, exhibit desirable in vitro and in vivo binding characteristics to the 5-HT1A receptor. Among other advantageous parameters, contemplated compounds retain high binding affinity, display optimal lipophilicity, and are radiolabeled efficiently with 18F-fluorine in a single step. Still further, contemplated compounds exhibit high target to non-target ratios in receptor-rich regions both in vitro and in vivo, and selected compounds can be effectively and sensitively displaced by serotonin, thus providing a quantitative tool for measuring 5-HT1A receptors and serotonin concentration changes in the living brain.

  18. Compositions and methods related to serotonin 5-HT1A receptors

    DOE Patents [OSTI]

    Mukherjee, Jogeshwar; Saigal, Neil

    2010-06-08

    Contemplated substituted arylpiperazinyl compounds, and most preferably 18F-Mefway, exhibit desirable in vitro and in vivo binding characteristics to the 5-HT1A receptor. Among other advantageous parameters, contemplated compounds retain high binding affinity, display optimal lipophilicity, and are radiolabeled efficiently with 18F-fluorine in a single step. Still further, contemplated compounds exhibit high target to non-target ratios in receptor-rich regions both in vitro and in vivo, and selected compounds can be effectively and sensitively displaced by serotonin, thus providing a quantitative tool for measuring 5-HT1A receptors and serotonin concentration changes in the living brain.

  19. 6430.1A Compliance Matrix for 241-SY-101 Surface Level Rise Remediation Project

    SciTech Connect (OSTI)

    ERHART, M.F.

    1999-10-08

    This document shows compliance with DOE order 6430.1A of the 241-SY-101 RAPID Mitigation system. The purpose of this document is to record the design attributes of the RAPID Mitigation System which fulfill the pertinent requirements specified in DOE Order 6430.1A-General Design Criteria. Those pertinent Order requirements which are not met by the project at the time of the release of this document are recorded and noted as open items in Section 4.0-Conclusions.

  20. Inducible bilirubin oxidase: A novel function for the mouse cytochrome P450 2A5

    SciTech Connect (OSTI)

    Abu-Bakar, A'edah; Arthur, Dionne Maioha; Cooperative Research Centre for Contamination Assessment and Remediation of the Environment, Adelaide ; Aganovic, Simona; Ng, Jack C.; Cooperative Research Centre for Contamination Assessment and Remediation of the Environment, Adelaide ; Lang, Matti A.; Department of Pharmaceutical Biosciences, Uppsala University, Biomedical Centre, Box 578, S-751 23 Uppsala

    2011-11-15

    We have previously shown that bilirubin (BR), a breakdown product of haem, is a strong inhibitor and a high affinity substrate of the mouse cytochrome P450 2A5 (CYP2A5). The antioxidant BR, which is cytotoxic at high concentrations, is potentially useful in cellular protection against oxygen radicals if its intracellular levels can be strictly controlled. The mechanisms that regulate cellular BR levels are still obscure. In this paper we provide preliminary evidence for a novel function of CYP2A5 as hepatic 'BR oxidase'. A high-performance liquid chromatography/electrospray ionisation mass spectrometry screening showed that recombinant yeast microsomes expressing the CYP2A5 oxidise BR to biliverdin, as the main metabolite, and to three other smaller products with m/z values of 301, 315 and 333. The metabolic profile is significantly different from that of chemical oxidation of BR. In chemical oxidation the smaller products were the main metabolites. This suggests that the enzymatic reaction is selective, towards biliverdin production. Bilirubin treatment of primary hepatocytes increased the CYP2A5 protein and activity levels with no effect on the corresponding mRNA. Co-treatment with cycloheximide (CHX), a protein synthesis inhibitor, resulted in increased half-life of the CYP2A5 compared to cells treated only with CHX. Collectively, the observations suggest that the CYP2A5 is potentially an inducible 'BR oxidase' where BR may accelerate its own metabolism through stabilization of the CYP2A5 protein. It is possible that this metabolic pathway is potentially part of the machinery controlling intracellular BR levels in transient oxidative stress situations, in which high amounts of BR are produced. -- Highlights: Black-Right-Pointing-Pointer CYP2A5 metabolizes bilirubin to biliverdin and dipyrroles. Black-Right-Pointing-Pointer Bilirubin increased the hepatic CYP2A5 protein and activity levels. Black-Right-Pointing-Pointer Bilirubin does not change the hepatic CYP2A5

  1. High-quality permanent draft genome sequence of Bradyrhizobium sp. Tv2a.2, a microsymbiont of Tachigali versicolor discovered in Barro Colorado Island of Panama

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Tian, Rui; Parker, Matthew; Seshadri, Rekha; Reddy, TBK; Markowitz, Victor; Ivanova, Natalia; Pati, Amrita; Woyke, Tanja; Baeshen, Mohammed N.; Baeshen, Nabih A.; et al

    2015-05-17

    Bradyrhizobiumsp. Tv2a.2 is an aerobic, motile, Gram-negative, non-spore-forming rod that was isolated from an effective nitrogen-fixing root nodule of Tachigali versicolor collected in Barro Colorado Island of Panama. Here we describe the features of Bradyrhizobiumsp. Tv2a.2, together with high-quality permanent draft genome sequence information and annotation. The 8,496,279 bp high-quality draft genome is arranged in 87 scaffolds of 87 contigs, contains 8,109 protein-coding genes and 72 RNA-only encoding genes. In conclusion, this rhizobial genome was sequenced as part of the DOE Joint Genome Institute 2010 Genomic Encyclopedia for Bacteria and Archaea-Root Nodule Bacteria (GEBA-RNB) project.

  2. Notice of Intent to Revise DOE O 200.1A, Information Technology Management--Withdrawn

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-12-15

    Withdrawn 3-24-14. Although DOE O 200.1A was revised in December 2008, there have been significant changes in IT governance processes and Departmental use of new technologies such as Web 2.0 technologies since that time.

  3. Mirror Advanced Reactor Study (MARS). Final report. Volume 1-A. Commercial fusion electric plant

    SciTech Connect (OSTI)

    Donohue, M.L.; Price, M.E.

    1984-07-01

    Volume 1-A contains the following chapters: (1) plasma engineering, (2) magnets, (3) ecr heating systems, (4) anchor ion-cyclotron resonance heating system, (5) sloshing ion neutral beam, (6) end cell structure, (7) end plasma technology, (8) fueling, (9) startup ion cyclotron resonant heating systems, and (10) end cell radiation analysis. (MOW)

  4. Canister storage building compliance assessment DOE Order 6430.1A, General Design Criteria

    SciTech Connect (OSTI)

    BLACK, D.M.

    1999-08-12

    This document presents the Project's position on compliance with DOE Order 6430.1A ''General Design Criteria.'' No non-compliances are shown. The compliance statements have been reviewed and approved by DOE. Open items are scheduled to be closed prior to project completion.

  5. Final Report for the ADMX Phase 2a Project at the University of Washington

    SciTech Connect (OSTI)

    Rosenberg, Leslie J.

    2015-08-22

    This is a final report of the ADMX Phase 2a program. This program is a project allowing for a sensitive axion dark-matter axion search at higher axion masses. The Phase 2a program also prepares the project for lower temperature anticipated in later operations. The Phase 2a program includes sensitive data-taking operations at two cavity modes, TM010 and TM020, allowing for faster data-taking operations and extending the search to higher and plausible dark-matter axion masses.

  6. Webinar: Critical Updates to the Hydrogen Analysis Production Model (H2A

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    v3) | Department of Energy Critical Updates to the Hydrogen Analysis Production Model (H2A v3) Webinar: Critical Updates to the Hydrogen Analysis Production Model (H2A v3) Below is the text version of the webinar titled "Critical Updates to the Hydrogen Analysis Production Model (H2A v3)," originally presented on February 8, 2012. In addition to this text version of the audio, you can access the presentation slides. Darlene Steward: So I have a little presentation here. The real

  7. Webinar: Guidance for Filling Out a Detailed H2A Production Case Study |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Guidance for Filling Out a Detailed H2A Production Case Study Webinar: Guidance for Filling Out a Detailed H2A Production Case Study Below is the text version of the webinar titled "Guidance for Filling Out a Detailed H2A Production Case Study," originally presented on July 9, 2013. In addition to this text version of the audio, you can access the presentation slides. Alli Aman: Thanks so much for joining today's webinar. Just to go through a few housekeeping

  8. TOSPAC calculations in support of the COVE 2A benchmarking activity; Yucca Mountain Site Characterization Project

    SciTech Connect (OSTI)

    Gauthier, J.H.; Zieman, N.B.; Miller, W.B.

    1991-10-01

    The purpose of the the Code Verification (COVE) 2A benchmarking activity is to assess the numerical accuracy of several computer programs for the Yucca Mountain Site Characterization Project of the Department of Energy. This paper presents a brief description of the computer program TOSPAC and a discussion of the calculational effort and results generated by TOSPAC for the COVE 2A problem set. The calculations were performed twice. The initial calculations provided preliminary results for comparison with the results from other COVE 2A participants. TOSPAC was modified in response to the comparison and the final calculations included a correction and several enhancements to improve efficiency. 8 refs.

  9. Waste Receiving and Processing Facility Module 2A: Advanced Conceptual Design Report. Volume 3B

    SciTech Connect (OSTI)

    Not Available

    1994-03-01

    This volume consists of the following sections: WRAP 2A value engineering assessment, resolution of value engineering assessment actions (white paper), HAZOP studies for identifying major safety and operability problems, and time and motion simulation.

  10. Heat Flow in VC-2A and VC-2B, and Constraints on the Thermal...

    Open Energy Info (EERE)

    to: navigation, search OpenEI Reference LibraryAdd to library Conference Paper: Heat Flow in VC-2A and VC-2B, and Constraints on the Thermal Regime of the Valles Caldera, New...

  11. EIA Energy Efficiency-Table 2a. First Use for All Purposes (Primary...

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    a Page Last Modified: May 2010 Table 2a. Consumption of Energy (Primary 1 Energy) for All Purposes (First Use) for Selected Industries, 1998, 2002, and 2006 (Trillion Btu) MECS...

  12. Brine pH Modification Scale Control Technology. 2. A Review.pdf...

    Open Energy Info (EERE)

    Brine pH Modification Scale Control Technology. 2. A Review.pdf Jump to: navigation, search OpenEI Reference LibraryAdd to library Journal Article: Brine pH Modification Scale...

  13. Project Description Advanced Fuel Cycle Initiative AFC-2A and AFC-2B Experiments

    SciTech Connect (OSTI)

    AFCI AFC-2A and AFC-2B Experiments Project Executi

    2007-03-01

    The proposed AFC-2A and AFC-2B irradiation experiments are a continuation of the AFC-1 fuel test series currently in progress in the ATR. This document discusses the experiments and the planned activities that will take place.

  14. Colorado - C.R.S. 24-4-105(2)(a) - Hearings and Determinations...

    Open Energy Info (EERE)

    search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: Colorado - C.R.S. 24-4-105(2)(a) - Hearings and DeterminationsLegal Abstract This section outline the...

  15. Waste Receiving and Processing Facility Module 2A: Advanced Conceptual Design Report. Volume 3A

    SciTech Connect (OSTI)

    Not Available

    1994-03-01

    Objective of this document is to provide descriptions of all WRAP 2A feed streams, including physical and chemical attributes, and describe the pathway that was used to select data for volume estimates. WRAP 2A is being designed for nonthermal treatment of contact-handled mixed low-level waste Category 1 and 3. It is based on immobilization and encapsulation treatment using grout or polymer.

  16. H2A Delivery: Forecourt Compression & Storage Optimization (Part II) |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Delivery: Forecourt Compression & Storage Optimization (Part II) H2A Delivery: Forecourt Compression & Storage Optimization (Part II) Presentation by Matthew Hooks of TIAX at the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007 deliv_analysis_hooks.pdf (482.38 KB) More Documents & Publications H2A Delivery: GH2 and LH2 Forecourt Land Areas Forecourt Storage and Compression Options

  17. CX-000388: Categorical Exclusion Determination

    Office of Energy Efficiency and Renewable Energy (EERE)

    Sandia Technologies LLCCX(s) Applied: A1, A9Date: 11/13/2009Location(s): Houston, TexasOffice(s): Fossil Energy, National Energy Technology Laboratory

  18. CX-000410: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Deepwater Riserless Intervention SystemCX(s) Applied: A1, A9Date: 12/17/2009Location(s): Houston, TexasOffice(s): Fossil Energy, National Energy Technology Laboratory

  19. Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation-A mammalian cell-based mutagenesis approach

    SciTech Connect (OSTI)

    Chiang, Huai-chih; Wang, Chin-Ying; Lee, Hui-Ling; Tsou, Tsui-Chun

    2011-06-01

    Both cytochrome P450 2A6 (CYP2A6) and cytochrome P450 2A13 (CYP2A13) are involved in metabolic activation of tobacco-specific nitrosamines and may play important roles in cigarette smoking-induced lung cancer. Unlike CYP2A6, effects of CYP2A13 on the tobacco-specific nitrosamine-induced mutagenesis in lung cells remain unclear. This study uses a supF mutagenesis assay to examine the relative effects of CYP2A6 and CYP2A13 on metabolic activation of a tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and its resulting mutagenesis in human lung cells. A recombinant adenovirus-mediated CYP2A6/CYP2A13 expression system was established to specifically address the relative effects of these two CYPs. Mutagenesis results revealed that both CYP2A6 and CYP2A13 significantly enhanced the NNK-induced supF mutation and that the mutagenic effect of CYP2A13 was markedly higher than that of CYP2A6. Analysis of NNK metabolism indicated that {>=} 70% of NNK was detoxified to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), either with or without CYP2A6/CYP2A13 expression. Both CYP2A6 and CYP2A13 significantly enhanced the {alpha}-hydroxylation of NNK; and the {alpha}-hydroxylation activity of CYP2A13 was significantly higher than that of CYP2A6. Analysis of the NNK-related DNA adduct formation indicated that, in the presence of CYP2A13, NNK treatments caused marked increases in O{sup 6}-methylguanine (O{sup 6}-MeG). The present results provide the first direct in vitro evidence demonstrating the predominant roles of CYP2A13 in NNK-induced mutagenesis, possibly via metabolic activation of NNK {alpha}-hydroxylation.

  20. DOE Order 412.1a, Work Authorization System Administrative Change

    Broader source: Energy.gov [DOE]

    "The purpose of this Flash is to inform contracting personnel the department issued an administrative change to DOE Order 412.1a, Work Authorization System. The changes update organizational names, references, websites, etc. Attached is a summary of the change with the updated order. Additionally, the order may be found at: https://www.directives.doe.gov/directives-documents/0412.1-BOrder-A-admchg1"

  1. Minimum Fisher regularization of image reconstruction for infrared imaging bolometer on HL-2A

    SciTech Connect (OSTI)

    Gao, J. M.; Liu, Y.; Li, W.; Lu, J.; Dong, Y. B.; Xia, Z. W.; Yi, P.; Yang, Q. W.

    2013-09-15

    An infrared imaging bolometer diagnostic has been developed recently for the HL-2A tokamak to measure the temporal and spatial distribution of plasma radiation. The three-dimensional tomography, reduced to a two-dimensional problem by the assumption of plasma radiation toroidal symmetry, has been performed. A three-dimensional geometry matrix is calculated with the one-dimensional pencil beam approximation. The solid angles viewed by the detector elements are taken into account in defining the chord brightness. And the local plasma emission is obtained by inverting the measured brightness with the minimum Fisher regularization method. A typical HL-2A plasma radiation model was chosen to optimize a regularization parameter on the criterion of generalized cross validation. Finally, this method was applied to HL-2A experiments, demonstrating the plasma radiated power density distribution in limiter and divertor discharges.

  2. A new neutral particle analyzer diagnostic and its first commissioning on HL-2A

    SciTech Connect (OSTI)

    Li, W.; Xia, Z. W.; Lu, J.; Yang, Q. W.; Ding, X. T.

    2012-10-15

    A new neutral particle analyzer diagnostic has been developed for HuanLiuqi-2A (commonly referred to as HL-2A), which can provide the neutral particle flux measurement along 11 separate sightlines, simultaneously, within a wider energy range (1-70 keV). It is an electrostatic type analyzer with a removable pinhole and special-shape condenser. The energy analysis can be flexibly achieved by controlling a preset stepwise high voltage on the condenser. It is compact and its field of view covers HL-2A cross section from -33 cm to 33 cm without 'cross-talk.' The energy spectra and ion temperature profile have been obtained during its commissioning.

  3. EGR Control for Emisson Reduction Using Fast Response Sensors - Phase 1A

    SciTech Connect (OSTI)

    Gravel, Roland; Conley, Jason; Kittelson, David

    2008-09-30

    The overall objective of this project was to develop exhaust gas recirculation (EGR) control strategies using fast-response Particulate Matter (PM) sensors and NOx sensors to improve the quality of particulate and gaseous emissions from diesel engines. This project initially comprised three phases: (1) Phase IA - sensor requirements to meet PM sensor specifications, NOx sensor assessment, and initial model development for EGR control; (2) Phase IB - continue development on PM and NOx sensors, integrate the sensor signals into the control simulations, and finalize model development for control strategies; and (3) Phase II - validation testing of the control strategies. Only Phase 1A was funded by DOE and executed by Honeywell. The major objectives of Phase 1A of the project included: (1) Sensor validation and operation of fast-response PM and NOx sensors; (2) Control system modeling of low-pressure EGR controls, development of control strategies, and initial evaluation of these models and strategies for EGR control in diesel engines; (3) Sensor testing to understand applicability of fast-response PM sensors in determining loading rates of the particle trap; and (4) Model validation and sensor testing under steady-state and transient operational conditions of actual engines. In particular, specific objectives included demonstration of: (1) A PM sensor response time constant (T10 - T90) of better than 100 milliseconds (msec); (2) The ability to detect PM at concentrations from 0.2 to 2 Bosch smoke number (BSN) or equivalent; (3) PM sensor accuracy to within 20% BSN over the entire range of operation; and (4) PM sensor repeatability to within 10% over the PM entire sensor range equivalent to a BSN of 0.2 to 2.

  4. H2A Biomethane Model Documentation and a Case Study for Biogas From Dairy Farms

    SciTech Connect (OSTI)

    Saur, G.; Jalalzadeh, A.

    2010-12-01

    The new H2A Biomethane model was developed to estimate the levelized cost of biomethane by using the framework of the vetted original H2A models for hydrogen production and delivery. For biomethane production, biogas from sources such as dairy farms and landfills is upgraded by a cleanup process. The model also estimates the cost to compress and transport the product gas via the pipeline to export it to the natural gas grid or any other potential end-use site. Inputs include feed biogas composition and cost, required biomethane quality, cleanup equipment capital and operations and maintenance costs, process electricity usage and costs, and pipeline delivery specifications.

  5. COVE 2A Benchmarking calculations using NORIA; Yucca Mountain Site Characterization Project

    SciTech Connect (OSTI)

    Carrigan, C.R.; Bixler, N.E.; Hopkins, P.L.; Eaton, R.R.

    1991-10-01

    Six steady-state and six transient benchmarking calculations have been performed, using the finite element code NORIA, to simulate one-dimensional infiltration into Yucca Mountain. These calculations were made to support the code verification (COVE 2A) activity for the Yucca Mountain Site Characterization Project. COVE 2A evaluates the usefulness of numerical codes for analyzing the hydrology of the potential Yucca Mountain site. Numerical solutions for all cases were found to be stable. As expected, the difficulties and computer-time requirements associated with obtaining solutions increased with infiltration rate. 10 refs., 128 figs., 5 tabs.

  6. Synthesis of heterocycles: Indolo (2,1-a) isoquinolines, renewables, and aptamer ligands for cellular imaging

    SciTech Connect (OSTI)

    Beasley, Jonathan

    2013-05-07

    In this thesis, we explore both total syntheses and methodologies of several aromatic heterocyclic molecules. Extensions of the Kraus indole synthesis toward 2-substituted and 2,3-disubstituted indoles, as well as biologically attractive indolo[2,1-a]isoquinolines are described. Recent renewable efforts directed to commodity maleic acid and the first reported furan-based ionic liquids are described. Our total synthesis of mRNA aptamer ligand PDC-Gly, and its dye coupled forms, plus aminoglycoside dye coupled ligands used in molecular imaging, are described.

  7. Inverter Load Rejection Over-Voltage Testing: SolarCity CRADA Task 1a Final Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Inverter Load Rejection Over-Voltage Testing SolarCity CRADA Task 1a Final Report A. Nelson, A. Hoke, and S. Chakraborty National Renewable Energy Laboratory J. Chebahtah, T. Wang, and B. Zimmerly SolarCity Corporation Technical Report NREL/TP-5D00-63510 February 2015 NREL is a national laboratory of the U.S. Department of Energy Office of Energy Efficiency & Renewable Energy Operated by the Alliance for Sustainable Energy, LLC This report is available at no cost from the National Renewable

  8. New Whole-House Solutions Case Study: David Weekley Homes, Houston...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    The team used advanced framing techniques that include open headers over windows, 2x6 24-inch on-center framing with framing member alignment, two-stud corners, insulated corners, ...

  9. Progress Report- DE-FG02-03ER46078-University of Houston

    Office of Scientific and Technical Information (OSTI)

    These results have been included in a PRB paper. Water in Carbon Nanotubes Earlier ... the momentum distribution relative to that of water, the recent results show a broadening. ...

  10. Houston Visit Highlights People and Programs Helping the Office of Fossil Energy Fulfill Its Mission

    Office of Energy Efficiency and Renewable Energy (EERE)

    When I joined the Office of Fossil Energy as Deputy Assistant Secretary for Oil and Natural Gas this past September, three areas made an immediate impression: the office’s highly innovative research and development portfolio; the expertise of FE staff and their collaborative, constructive relationship with industry, state, international and academic research partners; and how the mission of FE in general, and ONG in particular, is essential to developing a secure, sustainable and clean energy future.

  11. Building America Whole-House Solutions for New Homes: David Weekely Homes, Houston, Texas

    Broader source: Energy.gov [DOE]

    Case study of David Weekley Homes, who worked with Building America research partner Building Science Corporation to design HERS-59 homes with advanced framed walls, airtight drywall, and rigid foam wall sheathing.

  12. Microsoft Word - DOE-ID-14-050 University of Houston EC B3-6...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    shake table. SECTION C. Environmental Aspects Potential Sources of Impact The action consists of constructing a model of an SMR and test the model on a shake table. The...

  13. The Texas Job Fair (presented by the Houston Area Consortium of Career Centers)

    Office of Energy Efficiency and Renewable Energy (EERE)

    Each spring, HACCC hosts the Texas Job Fair - one of the largest college job fairs in Texas! This event attracts over 1,500 students and alumni from HACCC institutions, in addition to graduates from institutions throughout Texas. To learn more about The Texas Job Fair, use the links to right.

  14. DOE Zero Energy Ready Home Case Study: M Street Homes, Houston...

    Energy Savers [EERE]

    powered by a small efficient natural gas generator that produces electricity with photovoltaic and battery backup. The generator's belt also mechanically drives the compressor...

  15. New Whole-House Solutions Case Study: David Weekley Homes, Houston, Texas

    SciTech Connect (OSTI)

    none,

    2012-04-01

    This builder worked with Building Science Corporation to design HERS-59 homes with advanced framed walls, airtight drywall, and rigid foam wall sheathing.

  16. DOE Zero Energy Ready Home Case Study: M Street Homes — Smartlux on Greenpark, Houston, TX

    SciTech Connect (OSTI)

    none,

    2014-09-01

    This builder certified its first DOE Zero Energy Ready Home and won a Production Builder honor in the 2014 Housing Innovation Awards. It is the first home in the world to use a tri-generation system to supply electricity, heating, and cooling on site.

  17. Revised neutron dosimetry results for the MOTA-2A experiment in FFTF

    SciTech Connect (OSTI)

    Greenwood, L.R.

    1994-09-01

    Revised neutron fluence and damage values are reported for the MOTA-2A experiment in the Fast Flux Test Facility (FFTF). This revision corrects an error with processing of the {sup 235}U(n,f) reaction. Net corrections are on the order of 5%.

  18. MREG V1.1 : a multi-scale image registration algorithm for SAR applications.

    SciTech Connect (OSTI)

    Eichel, Paul H.

    2013-08-01

    MREG V1.1 is the sixth generation SAR image registration algorithm developed by the Signal Processing&Technology Department for Synthetic Aperture Radar applications. Like its predecessor algorithm REGI, it employs a powerful iterative multi-scale paradigm to achieve the competing goals of sub-pixel registration accuracy and the ability to handle large initial offsets. Since it is not model based, it allows for high fidelity tracking of spatially varying terrain-induced misregistration. Since it does not rely on image domain phase, it is equally adept at coherent and noncoherent image registration. This document provides a brief history of the registration processors developed by Dept. 5962 leading up to MREG V1.1, a full description of the signal processing steps involved in the algorithm, and a user's manual with application specific recommendations for CCD, TwoColor MultiView, and SAR stereoscopy.

  19. 6430.1A Compliance Matrix for 241-SY-101 Surface Level Rise Remediation Project

    SciTech Connect (OSTI)

    ERHART, M.F.

    1999-08-18

    Tank 241-SY-101 (SY-101) has recently exhibited a steady waste surface level growth. A path forward to mitigate the SY-101 surface level growth issue has been developed. The project has been directed to install the necessary equipment to transfer 380-570m{sup 3} (100,000-150,000 gallons) of waste from SY-101 to SY-102 before the waste elevation reached the region of the tank where the transition from a double to a single shell tank occurs. The purpose of this document is to record the design attributes of the RAPID mitigation system which fulfill the requirements specified in DOE order 6430.1A as it relates to the 241-SY-101 RAPID Mitigation System.

  20. Computer media security considerations: DOE Order 5635. 1A and DOE Order 5637. 1

    SciTech Connect (OSTI)

    Clever, J.J.

    1988-01-01

    This paper suggests that the examples for marking computer and word processing media and the written specifications for marking word processing media, contained in Chapter III, DOE Order 5635.1A, are technically incorrect. SNLA study indicates that strict compliance can lead to damage to the computer media drive and/or media itself. A model for technically appropriate marking is recommended which would facilitate longer distance visual identification of sensitive media, allow proper human readable identification of the classification levels, categories, special access/handling, and accountability/control data as applicable to the specific media. A diskette labeling example is provided which will meet the model requirements and which will not adversely act to cause damage to either the computer drive or the media. 5 refs., 15 figs.

  1. Experiment summary for n/y attenuation through materials (Environments 1A).

    SciTech Connect (OSTI)

    DePriest, Kendall Russell

    2006-05-01

    The Radiation Effects Sciences (RES) program is responsible for conducting Neutron Gamma Energy Transport (NuGET) code validation. In support of this task, a series of experiments were conducted in the annular core research reactor (ACRR) to investigate the modification of the incident neutron/gamma environment by aluminum (Al6061) and high-density polyethylene (HDPE) spheres with 4-in and 7-in-diameter. The experiment series described in this report addresses several NuGET validation concerns. The validation experiment series also addresses the design and execution of proper reactor testing to match the hostile radiation environments and to match the component stresses that arise from the hostile radiation environments. This report summarizes the RES Validation: n/{gamma} Attenuation through Materials, Environments 1A, experiments conducted at the ACRR in FY 2003 using ACRR Experiment Plans 933 and 949.

  2. Optics of ion beams for the neutral beam injection system on HL-2A Tokamak

    SciTech Connect (OSTI)

    Zou, G. Q.; Lei, G. J.; Cao, J. Y.; Duan, X. R.

    2012-07-15

    The ion beam optics for the neutral beam injection system on HL-2A Tokomak is studied by two- dimensional numerical simulation program firstly, where the emitting surface is taken at 100 Debye lengths from the plasma electrode. The mathematical formulation, computation techniques are described. Typical ion orbits, equipotential contours, and emittance diagram are shown. For a fixed geometry electrode, the effect of plasma density, plasma potential and plasma electron temperature on ion beam optics is examined, and the calculation reliability is confirmed by experimental results. In order to improve ion beam optics, the application of a small pre-acceleration voltage ({approx}100 V) between the plasma electrode and the arc discharge anode is reasonable, and a lower plasma electron temperature is desired. The results allow optimization of the ion beam optics in the neutral beam injection system on HL-2A Tokomak and provide guidelines for designing future neutral beam injection system on HL-2M Tokomak.

  3. Fuel Cell Tri-Generation System Case Study using the H2A Stationary Model

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Fuel Cell Tri-Generation System Case Study using the H2A Stationary Model Darlene Steward/ Mike Penev National Renewable Energy Laboratory Integrated Stationary Power and Transportation Workshop Phoenix, Arizona October 27, 2008 National Renewable Energy Laboratory Innovation for Our Energy Future 2 Introduction Goal: Develop a cost analysis tool that will be flexible and comprehensive enough to realistically analyze a wide variety of potential combined heat and power/hydrogen production

  4. Numerical studies of electron cyclotron wave current drive on HL-2A tokamak

    SciTech Connect (OSTI)

    Li, J. C.; Gong, X. Y.; Dong, J. Q.; Song, S. D.; Gao, Q. D.; Zheng, P. W.; Du, D.

    2015-06-15

    The electron cyclotron wave (ECW) current drive (CD) for the HL-2A tokamak is investigated numerically with a new ray-tracing and Fokker-Planck code. The code is benchmarked with other well-tested linear and quasilinear codes and is then used to study the electron cyclotron current drive on the HL-2A tokamak. The wave propagation, power deposition, and driven-current profiles are presented. The effect of electron trapping is also assessed. It is found that quasilinear effects are negligible at the present ECW power levels and that when both waves are injected at an angle of 20° on the plasma equatorial plane, the CD efficiency for the HL-2A saturates at ∼0.029 × 10{sup 20 }A/W/m{sup 2} and ∼0.020 × 10{sup 20 }A/W/m{sup 2} for the 0.5 MW/68 GHz first harmonic ordinary (O1) and 1 MW/140 GHz second harmonic extraordinary (X2) modes, respectively. The effects of the plasma density, temperature, and wave-launching position on the driven current are also investigated analytically and numerically.

  5. NEW - DOE O 329.1A Chg 1 (Admin Chg), Excepted Service Authorities for EJ and EK Pay Plans

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    The order establishes requirements and responsibilities for the employment and compensation of individuals when using DOE expected service authorities. Supersedes DOE O 329.1A.

  6. TANK 18 AND 19-F TIER 1A EQUIPMENT FILL MOCK UP TEST SUMMARY

    SciTech Connect (OSTI)

    Stefanko, D.; Langton, C.

    2011-11-04

    The United States Department of Energy (US DOE) has determined that Tanks 18-F and 19-F have met the F-Tank Farm (FTF) General Closure Plan Requirements and are ready to be permanently closed. The high-level waste (HLW) tanks have been isolated from FTF facilities. To complete operational closure they will be filled with grout for the purpose of: (1) physically stabilizing the tanks, (2) limiting/eliminating vertical pathways to residual waste, (3) discouraging future intrusion, and (4) providing an alkaline, chemical reducing environment within the closure boundary to control speciation and solubility of select radionuclides. Bulk waste removal and heel removal equipment remain in Tanks 18-F and 19-F. This equipment includes the Advance Design Mixer Pump (ADMP), transfer pumps, transfer jets, standard slurry mixer pumps, equipment-support masts, sampling masts, dip tube assemblies and robotic crawlers. The present Tank 18 and 19-F closure strategy is to grout the equipment in place and eliminate vertical pathways by filling voids in the equipment to vertical fast pathways and water infiltration. The mock-up tests described in this report were intended to address placement issues identified for grouting the equipment that will be left in Tank 18-F and Tank 19-F. The Tank 18-F and 19-F closure strategy document states that one of the Performance Assessment (PA) requirements for a closed tank is that equipment remaining in the tank be filled to the extent practical and that vertical flow paths 1 inch and larger be grouted. The specific objectives of the Tier 1A equipment grout mock-up testing include: (1) Identifying the most limiting equipment configurations with respect to internal void space filling; (2) Specifying and constructing initial test geometries and forms that represent scaled boundary conditions; (3) Identifying a target grout rheology for evaluation in the scaled mock-up configurations; (4) Scaling-up production of a grout mix with the target rheology

  7. A materials compatibility study in FM-1, a liquid component of a paste extrudable explosive

    SciTech Connect (OSTI)

    Goods, S.H.; Shepodd, T.J.; Mills, B.E.; Foster, P.

    1993-09-01

    The chemical compatibility of various metallic and organic containment materials with a constituent of a paste extrudable explosive (PEX) has been examined through a series of long-term exposures. Corrosion coupons and mechanical test specimens (polymers only) were exposed to FM-1, a principal liquid component of PEX, at 74{degree}C. RX-08-FK is the LLNL designator for this formulation. Compatibility was determined by measuring changes in weight, physical dimensions, and mechanical properties, by examining the coupons for discoloration, surface attack, and corrosion products, and by analyzing for dissolved metals in the FM-1. Of the metals and alloys examined, none of the 300 series stainless steels exhibited adequate corrosion resistance after 74 days of exposure. Copper showed evidence of severe uniform surface attack. Monel 400 also exhibited signs of chemical attack. Nickel and tantalum showed less evidence of attack, although neither, was immune to the liquid. Gold coupons developed a ``tarnish`` film. The gold along with an aluminum alloy, 6061 (in the T6 condition) performed the most satisfactorily. A wide range of polymers were tested for 61 days at 74{degree}C. The materials that exhibited the most favorable response in terms of weight change, dimensional stability, and mechanical properties were Kalrez, PTFE Teflon, and polyethylene.

  8. Polycyclic aromatic hydrocarbon-DNA adducts and the CYP1A1 restriction fragment length polymorphism

    SciTech Connect (OSTI)

    Shields, P.G.; Bowman, E.D.; Weston, A.; Harris, C.C.; Sugimura, H.; Caporaso, N.E.; Petruzzelli, S.F. ); Trump, B.F. )

    1992-11-01

    Human cancer risk assessment at a genetic level involves the investigation of carcinogen metabolism and DNA adduct formation. Wide interindividual differences in metabolism result in different DNA adduct levels. For this and other reasons, many laboratories have considered DNA adducts to be a measure of the biologically effective dose of a carcinogen. Techniques for studying DNA adducts using chemically specific assays are becoming available. A modification of the [sup 32]P-postlabeling assay for polycyclic aromatic hydrocarbon DNA adducts described here provides potential improvements in quantification. DNA adducts, however, reflect only recent exposure to carcinogens; in contrast, genetic testing for metabolic capacity indicates the extent to which carcinogens can be activated and exert genotoxic effects. Such studies may reflect both separate and integrated risk factors together with DNA adduct levels. A recently described restriction fragment length polymorphism for the CYP1A1, which codes for the cytochrome P450 enzyme primarily responsible for the metabolic activation of carcinogenic polycyclic aromatic hydrocarbons, has been found to be associated with lung cancer risk in a Japanese population. In a subset of individuals enrolled in a US lung cancer case-control study, no association with lung cancer was found. 17 refs., 3 figs.

  9. Lipid rafts regulate PCB153-induced disruption of occludin and brain endothelial barrier function through protein phosphatase 2A and matrix metalloproteinase-2

    SciTech Connect (OSTI)

    Eum, Sung Yong Jaraki, Dima; András, Ibolya E.; Toborek, Michal

    2015-09-15

    Occludin is an essential integral transmembrane protein regulating tight junction (TJ) integrity in brain endothelial cells. Phosphorylation of occludin is associated with its localization to TJ sites and incorporation into intact TJ assembly. The present study is focused on the role of lipid rafts in polychlorinated biphenyl (PCB)-induced disruption of occludin and endothelial barrier function. Exposure of human brain endothelial cells to 2,2′,4,4′,5,5′-hexachlorobiphenyl (PCB153) induced dephosphorylation of threonine residues of occludin and displacement of occludin from detergent-resistant membrane (DRM)/lipid raft fractions within 1 h. Moreover, lipid rafts modulated the reduction of occludin level through activation of matrix metalloproteinase 2 (MMP-2) after 24 h PCB153 treatment. Inhibition of protein phosphatase 2A (PP2A) activity by okadaic acid or fostriecin markedly protected against PCB153-induced displacement of occludin and increased permeability of endothelial cells. The implication of lipid rafts and PP2A signaling in these processes was further defined by co-immunoprecipitation of occludin with PP2A and caveolin-1, a marker protein of lipid rafts. Indeed, a significant MMP-2 activity was observed in lipid rafts and was increased by exposure to PCB153. The pretreatment of MMP-2 inhibitors protected against PCB153-induced loss of occludin and disruption of lipid raft structure prevented the increase of endothelial permeability. Overall, these results indicate that lipid raft-associated processes, such as PP2A and MMP-2 activation, participate in PCB153-induced disruption of occludin function in brain endothelial barrier. This study contributes to a better understanding of the mechanisms leading to brain endothelial barrier dysfunction in response to exposure to environmental pollutants, such as ortho-substituted PCBs. - Highlights: • PCB153 disturbed human brain endothelial barrier through disruption of occludin. • Lipid raft-associated PP

  10. Certification for DOE O 142.2A Admin Chg 1

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2014-12-03

    DOE Order 142.2A Admin Change 1, Voluntary Offer Safeguards Agreement and Additional Protocol with the International Atomic Energy Agency, 6/27/2013, has been reviewed by my organization and deemed to be in compliance with related Departmental Directives, Secretarial Delegations, organizational structure, budget guidelines, regulations, standards, OMB guidance, relevant memoranda of understanding and public laws. In addition, this directive is not found to cause undue burden (i.e., significant cost impacts, overly prescriptive, redundancy, or excessive reporting requirements) on Departmental elements and contractors.

  11. Planned revision to DOE Order 5820.2A, Radioactive Waste Management

    SciTech Connect (OSTI)

    Duggan, G.J.; Williams, R.E.; Kudera, D.E.; Bailey, D.E.

    1993-03-01

    US Department of Energy Headquarters initiated efforts to revise DOE Order 5820.2A, ``Radioactive Waste Management``. The purpose of the revision is to enhance DOE waste management requirements, reflect new DOE organizational responsibilities, and consolidate requirements for management of all waste, under the responsibility of Environmental Restoration and Waste Management, into a single order. This paper discusses the revision philosophy, objectives of the revision, and strategy for the revision. Issues being considered for inclusion in the revision and recommended methods of resolving each issue are also discussed.

  12. Environmental impact of Yucca Mountain repository after Urex+1a separation

    SciTech Connect (OSTI)

    Djokic, Denia; Ahn, Joonhong

    2007-07-01

    The environmental impact of Yucca Mountain Repository (YMR), expressed as the radiotoxicity of radionuclides released from failed waste packages, has been evaluated for the case of partitioning and vitrification the 63,000 MT of commercial spent nuclear fuel (CSNF) currently designated for disposal. A parametric study on the effect of fuel cycle parameters on environmental impact has also been conducted. CSNF inventory has been evaluated by using ORIGEN2. UREX+1a separation is considered as the base case, and the removal of individual nuclide groups has also been investigated. Of particular interest is the effect of Cs/Sr removal on the waste loading of a canister. An existing waste-conditioning model for high-level liquid waste (HLLW) solidification with borosilicate glass is used to determine the composition and waste loading of a vitrified waste canister by a set of waste loading constraints. A previously developed release model has been applied to evaluate the environmental impact of the vitrified waste packages in YMR. Numerical results show that while the removal of Tc and Cs/Sr does not have an effect on the environmental impact profile, it is linearly sensitive to separation efficiency of actinides. The uncertainty associated with the environmental impact resulting from the uncertainties of radionuclide solubility values has been computed. It was determined that in the case of U, TRU, Tc, and Cs/Sr inventory reduction by a factor of 100 and subsequent vitrification, the repository footprint would decrease by a factor of 3.4, implying that 3.4 times more electricity generation could be accommodated while the environmental impact is up to a factor of 100 smaller than the direct disposal case. (authors)

  13. Summary report on the fuel performance modeling of the AFC-2A, 2B irradiation experiments

    SciTech Connect (OSTI)

    Pavel G. Medvedev

    2013-09-01

    The primary objective of this work at the Idaho National Laboratory (INL) is to determine the fuel and cladding temperature history during irradiation of the AFC-2A, 2B transmutation metallic fuel alloy irradiation experiments containing transuranic and rare earth elements. Addition of the rare earth elements intends to simulate potential fission product carry-over from pyro-metallurgical reprocessing. Post irradiation examination of the AFC-2A, 2B rodlets revealed breaches in the rodlets and fuel melting which was attributed to the release of the fission gas into the helium gap between the rodlet cladding and the capsule which houses six individually encapsulated rodlets. This release is not anticipated during nominal operation of the AFC irradiation vehicle that features a double encapsulated design in which sodium bonded metallic fuel is separated from the ATR coolant by the cladding and the capsule walls. The modeling effort is focused on assessing effects of this unanticipated event on the fuel and cladding temperature with an objective to compare calculated results with the temperature limits of the fuel and the cladding.

  14. Table HC1-2a. Housing Unit Characteristics by Year of Construction,

    U.S. Energy Information Administration (EIA) Indexed Site

    2a. Housing Unit Characteristics by Year of Construction, Million U.S. Households, 2001 Housing Unit Characteristics RSE Column Factor: Total Year of Construction RSE Row Factors 1990 to 2001 1 1980 to 1989 1970 to 1979 1960 to 1969 1950 to 1959 1949 or Before 0.5 1.6 1.2 1.0 1.1 1.1 0.8 Total ............................................... 107.0 15.5 18.2 18.8 13.8 14.2 26.6 4.3 Census Region and Division Northeast ...................................... 20.3 1.5 2.4 2.1 2.8 3.0 8.5 8.8 New

  15. Sideward flow in Au+Au collisions between 2A and 8A GeV

    SciTech Connect (OSTI)

    Liu, H.; Ajitanand, N.N.; Alexander, J.; Anderson, M.; Best, D.; Brady, F.P.; Case, T.; Caskey, W.; Cebra, D.; Chance, J.; Cole, B.; Crowe, K.; Das, A.; Draper, J.; Gilkes, M.; Gushue, S.; Heffner, M.; Hirsch, A.; Hjort, E.; Huo, L.; Justice, M.; Kaplan, M.; Keane, D.; Kintner, J.; Klay, J.; Krofcheck, D.; Lacey, R.; Lisa, M.A.; Liu, Y.M.; McGrath, R.; Milosevich, Z.; Odyniec, G.; Olson, D.; Panitkin, S.Y.; Porile, N.; Rai, G.; Ritter, H.G.; Romero, J.; Scharenberg, R.; Schroeder, L.S.; Srivastava, B.; Stone, N.T.B.; Symons, T.J.M.; Wang, S.; Whitfield, J.; Wienold, T.; Witt, R.; Wood, L.; Yang, X.; Zhang, W.N.; Zhang, Y.; E895 Collaboration

    2000-04-05

    Using the large acceptance Time Projection Chamber of experiment E895 at Brookhaven, measurements of collective sideward flow in Au + Au collisions at beam energies of 2A, 4A, 6A, and 8A GeV are presented in the form of in-plane transverse momentum

  16. Waste Receiving and Processing Facility Module 2A: Advanced Conceptual Design Report. Volume 1

    SciTech Connect (OSTI)

    Not Available

    1994-03-01

    This ACDR was performed following completed of the Conceptual Design Report in July 1992; the work encompassed August 1992 to January 1994. Mission of the WRAP Module 2A facility is to receive, process, package, certify, and ship for permanent burial at the Hanford site disposal facilities the Category 1 and 3 contact handled low-level radioactive mixed wastes that are currently in retrievable storage at Hanford and are forecast to be generated over the next 30 years by Hanford, and waste to be shipped to Hanford from about DOE sites. This volume provides an introduction to the ACDR process and the scope of the task along with a project summary of the facility, treatment technologies, cost, and schedule. Major areas of departure from the CDR are highlighted. Descriptions of the facility layout and operations are included.

  17. Notice of Intent to Revise DOE Order 442.1A, Department of Energy Employee Concerns Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2016-06-14

    Revisions to DOE O 442.1A will help to bring about greater consistency throughout the DOE complex in the approach to processing employee concerns, and to support safety conscious work environment efforts.

  18. Analyzing the Levelized Cost of Centralized and Distributed Hydrogen Production Using the H2A Production Model, Version 2

    SciTech Connect (OSTI)

    Ramsden, T.; Steward, D.; Zuboy, J.

    2009-09-01

    Analysis of the levelized cost of producing hydrogen via different pathways using the National Renewable Energy Laboratory's H2A Hydrogen Production Model, Version 2.

  19. miR-4295 promotes cell proliferation and invasion in anaplastic thyroid carcinoma via CDKN1A

    SciTech Connect (OSTI)

    Shao, Mingchen; Geng, Yiwei; Lu, Peng; Xi, Ying; Wei, Sidong; Wang, Liuxing; Fan, Qingxia; Ma, Wang

    2015-09-04

    MicroRNAs (miRNAs) play important roles in the pathogenesis of many types of cancers by negatively regulating gene expression at posttranscriptional level. However, the role of microRNAs in anaplastic thyroid carcinoma (ATC), has remained elusive. Here, we identified that miR-4295 promotes ATC cell proliferation by negatively regulates its target gene CDKN1A. In ATC cell lines, CCK-8 proliferation assay indicated that the cell proliferation was promoted by miR-4295, while miR-4295 inhibitor significantly inhibited the cell proliferation. Transwell assay showed that miR-4295 mimics significantly promoted the migration and invasion of ATC cells, whereas miR-4295 inhibitors significantly reduced cell migration and invasion. luciferase assays confirmed that miR-4295 directly bound to the 3'untranslated region of CDKN1A, and western blotting showed that miR-4295 suppressed the expression of CDKN1A at the protein levels. This study indicated that miR-4295 negatively regulates CDKN1A and promotes proliferation and invasion of ATC cell lines. Thus, miR-4295 may represent a potential therapeutic target for ATC intervention. - Highlights: • miR-4295 mimics promote the proliferation and invasion of ATC cells. • miR-4295 inhibitors inhibit the proliferation and invasion of ATC cells. • miR-4295 targets 3′UTR of CDKN1A in ATC cells. • miR-4295 negatively regulates CDKN1A in ATC cells.

  20. JMJD2A attenuation affects cell cycle and tumourigenic inflammatory gene regulation in lipopolysaccharide stimulated neuroectodermal stem cells

    SciTech Connect (OSTI)

    Das, Amitabh; Chai, Jin Choul; Jung, Kyoung Hwa; Das, Nando Dulal; Kang, Sung Chul; Lee, Young Seek; Seo, Hyemyung; Chai, Young Gyu

    2014-11-01

    JMJD2A is a lysine trimethyl-specific histone demethylase that is highly expressed in a variety of tumours. The role of JMJD2A in tumour progression remains unclear. The objectives of this study were to identify JMJD2A-regulated genes and understand the function of JMJD2A in p53-null neuroectodermal stem cells (p53{sup −/−} NE-4Cs). We determined the effect of LPS as a model of inflammation in p53{sup −/−} NE-4Cs and investigated whether the epigenetic modifier JMJD2A alter the expression of tumourigenic inflammatory genes. Global gene expression was measured in JMJD2A knockdown (kd) p53{sup −/−} NE-4Cs and in LPS-stimulated JMJD2A-kd p53{sup −/−} NE-4C cells. JMJD2A attenuation significantly down-regulated genes were Cdca2, Ccnd2, Ccnd1, Crebbp, IL6rα, and Stat3 related with cell cycle, proliferation, and inflammatory-disease responses. Importantly, some tumour-suppressor genes including Dapk3, Timp2 and TFPI were significantly up-regulated but were not affected by silencing of the JMJD2B. Furthermore, we confirmed the attenuation of JMJD2A also down-regulated Cdca2, Ccnd2, Crebbp, and Rest in primary NSCs isolated from the forebrains of E15 embryos of C57/BL6J mice with effective p53 inhibitor pifithrin-α (PFT-α). Transcription factor (TF) motif analysis revealed known binding patterns for CDC5, MYC, and CREB, as well as three novel motifs in JMJD2A-regulated genes. IPA established molecular networks. The molecular network signatures and functional gene-expression profiling data from this study warrants further investigation as an effective therapeutic target, and studies to elucidate the molecular mechanism of JMJD2A-kd-dependent effects in neuroectodermal stem cells should be performed. - Highlights: • Significant up-regulation of epigenetic modifier JMJD2A mRNA upon LPS treatment. • Inhibition of JMJD2A attenuated key inflammatory and tumourigenic genes. • Establishing IPA based functional genomics in JMJD2A-attenuated p53{sup

  1. The motional Stark effect polarimeter in the HL-2A tokamak

    SciTech Connect (OSTI)

    Yu, D. L. Wei, Y. L.; Xia, F.; Cao, J. Y.; Chen, C. Y.; Liu, L.; Chen, W. J.; Ji, X. Q.; Liu, Y.; Yan, L. W.; Yang, Q. W.; Duan, X. R.

    2014-05-15

    A 7-channel motional Stark effect polarimeter based on four polarizers and a spectrometer has been developed in the HL-2A tokamak, which is the first time successful utilizing this kind of polarimeter on a tokamak. The accuracy of the angle can reach ±0.25° in the calibration experiments. Pilot experiments of measuring the magnetic pitch angle have been successfully carried out in the weak motional Stark effect plasma discharge with toroidal magnetic field of ∼1.3 T and beam energy of ∼25 keV/amu. The pitch angles of magnetic field are obtained for 7 spatial points covering 24 cm along major radius with time resolution of 40 ms; the profiles of safety factor are obtained by combining with the Equilibrium and Reconstruction Fitting Code. The core value of safety factor (q) is less than 1 during the sawtooth oscillation and the position of q = 1 surface is well consistent with the results measured by soft X-ray array.

  2. FORCE2: A multidimensional flow program for gas solids flow theory guide

    SciTech Connect (OSTI)

    Burge, S.W.

    1991-05-01

    This report describes the theory and structure of the FORCE2 flow program. The manual describes the governing model equations, solution procedure and their implementation in the computer program. FORCE2 is an extension of an existing B&V multidimensional, two-phase flow program. FORCE2 was developed for application to fluid beds by flow implementing a gas-solids modeling technology derived, in part, during a joint government -- industry research program, ``Erosion of FBC Heat Transfer Tubes,`` coordinated by Argonne National Laboratory. The development of FORCE2 was sponsored by ASEA-Babcock, an industry participant in this program. This manual is the principal documentation for the program theory and organization. Program usage and post-processing of code predictions with the FORCE2 post-processor are described in a companion report, FORCE2 -- A Multidimensional Flow Program for Fluid Beds, User`s Guide. This manual is segmented into sections to facilitate its usage. In section 2.0, the mass and momentum conservation principles, the basis for the code, are presented. In section 3.0, the constitutive relations used in modeling gas-solids hydrodynamics are given. The finite-difference model equations are derived in section 4.0 and the solution procedures described in sections 5.0 and 6.0. Finally, the implementation of the model equations and solution procedure in FORCE2 is described in section 7.0.

  3. DOE Order 5820.2A implementation status, progress and problems

    SciTech Connect (OSTI)

    Waldo, L.C.; Shepard, M.D.; Wilhite, E.L.

    1989-11-01

    The Department of Energy`s Order governing management of radioactive waste, DOE Order 5820.2A, was revised effective September 26, 1988. Chapter III of the Order contains prescriptive requirements for managing low-level waste. These requirements ensure that all DOE low-level radioactive and mixed waste will be managed in a systematic manner to achieve required performance., The Order defines performance objectives for low-level waste management to limit the dose received by the general public from waste operations, to protect groundwater resources, and to protect inadvertent intruders. For low-level waste disposal operations, the Order requires that a radiological performance assessment be prepared to demonstrate compliance with the performance objectives. The Order also requires that the radiological performance assessments be reviewed by a Peer Review Panel, established by the Order. This paper will summarize the requirements for radioactive waste management and discuss the degree of compliance achieved to date. The Department`s preliminary schedule and anticipated cost to achieve full compliance with the requirements will also be discussed.

  4. HIC1 interacts with a specific subunit of SWI/SNF complexes, ARID1A/BAF250A

    SciTech Connect (OSTI)

    Van Rechem, Capucine; Boulay, Gaylor; Leprince, Dominique

    2009-08-07

    HIC1, a tumor suppressor gene epigenetically silenced in many human cancers encodes a transcriptional repressor involved in regulatory loops modulating p53-dependent and E2F1-dependent cell survival and stress responses. HIC1 is also implicated in growth control since it recruits BRG1, one of the two alternative ATPases (BRM or BRG1) of SWI/SNF chromatin-remodeling complexes to repress transcription of E2F1 in quiescent fibroblasts. Here, through yeast two-hybrid screening, we identify ARID1A/BAF250A, as a new HIC1 partner. ARID1A/BAF250A is one of the two mutually exclusive ARID1-containing subunits of SWI/SNF complexes which define subsets of complexes endowed with anti-proliferative properties. Co-immunoprecipitation assays in WI38 fibroblasts and in BRG1-/- SW13 cells showed that endogenous HIC1 and ARID1A proteins interact in a BRG1-dependent manner. Furthermore, we demonstrate that HIC1 does not interact with BRM. Finally, sequential chromatin immunoprecipitation (ChIP-reChIP) experiments demonstrated that HIC1 represses E2F1 through the recruitment of anti-proliferative SWI/SNF complexes containing ARID1A.

  5. FORCE2: A state-of-the-art two-phase code for hydrodynamic calculations

    SciTech Connect (OSTI)

    Ding, Jianmin; Lyczkowski, R.W.; Burge, S.W.

    1993-02-01

    A three-dimensional computer code for two-phase flow named FORCE2 has been developed by Babcock and Wilcox (B & W) in close collaboration with Argonne National Laboratory (ANL). FORCE2 is capable of both transient as well as steady-state simulations. This Cartesian coordinates computer program is a finite control volume, industrial grade and quality embodiment of the pilot-scale FLUFIX/MOD2 code and contains features such as three-dimensional blockages, volume and surface porosities to account for various obstructions in the flow field, and distributed resistance modeling to account for pressure drops caused by baffles, distributor plates and large tube banks. Recently computed results demonstrated the significance of and necessity for three-dimensional models of hydrodynamics and erosion. This paper describes the process whereby ANL`s pilot-scale FLUFIX/MOD2 models and numerics were implemented into FORCE2. A description of the quality control to assess the accuracy of the new code and the validation using some of the measured data from Illinois Institute of Technology (UT) and the University of Illinois at Urbana-Champaign (UIUC) are given. It is envisioned that one day, FORCE2 with additional modules such as radiation heat transfer, combustion kinetics and multi-solids together with user-friendly pre- and post-processor software and tailored for massively parallel multiprocessor shared memory computational platforms will be used by industry and researchers to assist in reducing and/or eliminating the environmental and economic barriers which limit full consideration of coal, shale and biomass as energy sources, to retain energy security, and to remediate waste and ecological problems.

  6. FORCE2: A state-of-the-art two-phase code for hydrodynamic calculations

    SciTech Connect (OSTI)

    Ding, Jianmin; Lyczkowski, R.W. ); Burge, S.W. . Research Center)

    1993-02-01

    A three-dimensional computer code for two-phase flow named FORCE2 has been developed by Babcock and Wilcox (B W) in close collaboration with Argonne National Laboratory (ANL). FORCE2 is capable of both transient as well as steady-state simulations. This Cartesian coordinates computer program is a finite control volume, industrial grade and quality embodiment of the pilot-scale FLUFIX/MOD2 code and contains features such as three-dimensional blockages, volume and surface porosities to account for various obstructions in the flow field, and distributed resistance modeling to account for pressure drops caused by baffles, distributor plates and large tube banks. Recently computed results demonstrated the significance of and necessity for three-dimensional models of hydrodynamics and erosion. This paper describes the process whereby ANL's pilot-scale FLUFIX/MOD2 models and numerics were implemented into FORCE2. A description of the quality control to assess the accuracy of the new code and the validation using some of the measured data from Illinois Institute of Technology (UT) and the University of Illinois at Urbana-Champaign (UIUC) are given. It is envisioned that one day, FORCE2 with additional modules such as radiation heat transfer, combustion kinetics and multi-solids together with user-friendly pre- and post-processor software and tailored for massively parallel multiprocessor shared memory computational platforms will be used by industry and researchers to assist in reducing and/or eliminating the environmental and economic barriers which limit full consideration of coal, shale and biomass as energy sources, to retain energy security, and to remediate waste and ecological problems.

  7. file://C:\Documents%20and%20Settings\VM3\My%20Documents\hc6-1a_

    U.S. Energy Information Administration (EIA) Indexed Site

    Table HC6-1a. Usage Indicators by Climate Zone, Million U.S. Households, 2001 ________________________________________________________________________________________________________ | | | | | Climate Zone 1 | | |_________________________________________________| | | | | | | Fewer than 2,000 CDD and -- | | | |_______________________________________|2,000 CDD| | | | | | | or More | | | | | | Fewer |and Fewer| | |More than| 5,500 to| 4,000 to| than | than | Usage Indicators | Total |7,000

  8. file://C:\Documents%20and%20Settings\VM3\My%20Documents\hc6-2a_

    U.S. Energy Information Administration (EIA) Indexed Site

    2a. Usage Indicators by Year of Construction, Million U.S. Households, 2001 ___________________________________________________________________________________________________________ | | | | | Year of Construction | | |_____________________________________________________| | | | | | | | | | | 1990 | 1980 | 1970 | 1960 | 1950 | 1949 | | | to | to | to | to | to | or | Usage Indicators | Total | 2001 1 | 1989 | 1979 | 1969 | 1959 | Before |

  9. K and Mn co-doped BaCd{sub 2}As{sub 2}: A hexagonal structured...

    Office of Scientific and Technical Information (OSTI)

    K and Mn co-doped BaCdsub 2Assub 2: A hexagonal structured bulk diluted magnetic semiconductor with large magnetoresistance Citation Details In-Document Search Title: K and Mn ...

  10. Analysis of Well ER-EC-2a Testing, Western Pahute Mesa-Oasis Valley FY 2000 Testing Program

    SciTech Connect (OSTI)

    2002-09-30

    This report documents the analysis of the data collected for Well ER-EC-2a during the Western Pahute Mesa - Oasis Valley (WPM-OV) well development and testing program that was conducted during fiscal year (FY) 2000. The data collection for that program is documented in Appendix A, Western Pahute Mesa - Oasis Valley, Well ER-EC-2a Data Report for Development and Hydraulic Testing.

  11. Deficient expression of aldehyde dehydrogenase 1A1 is consistent with increased sensitivity of Gorlin syndrome patients to radiation carcinogenesis

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Wright, Aaron T.; Magnaldo, Thierry; Sontag, Ryan L.; Anderson, Lindsey N.; Sadler, Natalie C.; Piehowski, Paul D.; Gache, Yannick; Weber, Thomas J.

    2013-11-27

    Human phenotypes that are highly susceptible to radiation carcinogenesis have been identified. Sensitive phenotypes often display robust regulation of molecular features that modify biological response, which can facilitate identification of relevant pathways/networks. Here we interrogate primary dermal fibroblasts isolated from Gorlin syndrome patients (GDFs), who display a pronounced tumorigenic response to radiation, in comparison to normal human dermal fibroblasts (NHDFs). Our approach exploits newly developed thiol-reactive probes with a flexible click chemistry functional group to define changes in protein thiol profiles in live cell studies, which minimizes artifacts associated with cell lysis. We observe qualitative differences in protein thiol profilesmore » by SDS-PAGE analysis when detection by iodoacetamide vs maleimide probe chemistries are compared, and pretreatment of cells with hydrogen peroxide eliminates detection of the majority of SDS-PAGE bands. Redox probes revealed deficient expression of an apparent 55 kDa protein thiol in GDFs from independent donors, compared with NHDFs. Proteomics tentatively identified this protein as aldehyde dehydrogenase 1A1 (ALDH1A1), a key enzyme regulating retinoic acid synthesis, and this deficiency was confirmed by Western blot. Redox probes revealed additional protein thiol differences between GDFs and NHDFs, including radiation responsive annexin family members. Our results indicate a multifactorial basis for the unusual sensitivity of Gorlin syndrome to radiation carcinogenesis, and the pathways identified have plausible implications for radiation health effects.« less

  12. Work plan for phase 1A paleochannel studies at the Cheney disposal cell, Grand Junction, Colorado: Draft

    SciTech Connect (OSTI)

    1996-11-01

    This document will serve as a Work Plan for continuing paleochannel characterization activities at the Cheney disposal site near Grand Junction, Colorado. Elevated levels of nitrate were encountered in ground water from two monitor wells installed in alluvial paleochannels near the Cheney disposal cell in 1994. This triggered a series of investigations (Phase 1) designed to determine the source of nitrate and other chemical constituents in ground water at the site. A comprehensive summary of the Phase 1 field investigations (limited to passive monitoring and modeling studies) conducted by the Remedial Action Contractor (RAC) and Technical Assistance Contractor (TAC) to date is provided in Section 2.0 of this document. Results of Phase 1 were inconclusive regarding the potential interaction between the disposal cell and the paleochannels, so additional Phase 1A investigations are planned. Recommendations for Phase 1A tasks and possible future activities are discussed in Section 3.0. Detailed information on the implementation of the proposed Phase 1A tasks appears in Section 4.0 and will provide the basis for Statements of Work (SOW) for each of these tasks. A detailed sampling plan is provided to ensure quality and a consistency with previous data collection efforts.

  13. O{sub 2}(a{sup 1}{delta}{sub g}) production at atmospheric pressure by microdischarge

    SciTech Connect (OSTI)

    Sousa, J. Santos; Bauville, G.; Lacour, B.; Puech, V.; Touzeau, M.; Pitchford, L. C.

    2008-07-07

    We report experimental results showing that singlet oxygen O{sub 2}(a{sup 1}{delta}{sub g}) can be efficiently produced at atmospheric pressure in a three-electrode microcathode sustained discharge (MCSD) configuration. This configuration consists of a microhollow cathode discharge (MHCD) acting as a plasma cathode to sustain a stable glow discharge between the MHCD and a third planar electrode placed at a distance of 8 mm. Experiments were performed in He/O{sub 2}/NO mixtures. O{sub 2}(a{sup 1}{delta}{sub g}) number densities higher than 10{sup 16} cm{sup -3} were measured in the MCSD afterglow at total flow rates up to 30 ln/mn, resulting in O{sub 2}(a{sup 1}{delta}{sub g}) fluxes above 10 millimole per hour (mmol/h)

  14. Fixing two-nucleon weak-axial coupling L{sub 1,A} from {mu}{sup -}d capture

    SciTech Connect (OSTI)

    Chen, J.-W.; Inoue, Takashi; Ji Xiangdong; Li Yingchuan

    2005-12-15

    We calculate the muon capture rate on the deuteron to next-to-next-to-leading order in the pionless effective field theory. The result can be used to constrain the two-nucleon isovector axial coupling L{sub 1,A} to {+-}2 fm{sup 3} if the muon capture rate is measured to the 2% level. From this, one can determine the neutrino-deuteron breakup reactions and the pp fusion cross section in the sun to the same level of accuracy.

  15. Osteogenesis imperfecta type I: Molecular heterogeneity for COL1A1 null alleles of type I collagen

    SciTech Connect (OSTI)

    Willing, M.C.; Deschenes, S.P.; Pitts, S.H.; Arikat, H.; Roberts, E.J.; Scott, D.A.; Slayton, R.L.; Byers, P.H.

    1994-10-01

    Osteogenesis imperfecta (OI) type I is the mildest form of inherited brittle-bone disease. Dermal fibroblasts from most affected individuals produce about half the usual amount of type I procollagen, as a result of a COL1A1 {open_quotes}null{close_quotes} allele. Using PCR amplification of genomic DNA from affected individuals, followed by denaturing gradient gel electrophoresis (DGGE) and SSCP, we identified seven different COL1A1 gene mutations in eight unrelated families with OI type I. Three families have single nucleotide substitutions that alter 5{prime} donor splice sites; two of these unrelated families have the same mutation. One family has a point mutation, in an exon, that creates a premature termination codon, and four have small deletions or insertions, within exons, that create translational frameshifts and new termination codons downstream of the mutation sites. Each mutation leads to both marked reduction in steady-state levels of mRNA from the mutant allele and a quantitative decrease in type I procollagen production. Our data demonstrate that different molecular mechanisms that have the same effect on type I collagen production result in the same clinical phenotype. 58 refs., 4 figs., 1 tab.

  16. Advanced Gas Storage Concepts: Technologies for the Future

    SciTech Connect (OSTI)

    Freeway, Katy; Rogers, R.E.; DeVries, Kerry L.; Nieland, Joel D.; Ratigan, Joe L.; Mellegard, Kirby D.

    2000-02-01

    This full text product includes: 1) A final technical report titled Advanced Underground Gas Storage Concepts, Refrigerated-Mined Cavern Storage and presentations from two technology transfer workshops held in 1998 in Houston, Texas, and Pittsburgh, Pennsylvania (both on the topic of Chilled Gas Storage in Mined Caverns); 2) A final technical report titled Natural Gas Hydrates Storage Project, Final Report 1 October 1997 - 31 May 1999; 3) A final technical report titled Natural Gas Hydrates Storage Project Phase II: Conceptual Design and Economic Study, Final Report 9 June - 10 October 1999; 4) A final technical report titled Commerical Potential of Natural Gas Storage in Lined Rock Caverns (LRC) and presentations from a DOE-sponsored workshop on Alternative Gas Storage Technologies, held Feb 17, 2000 in Pittsburgh, PA; and 5) Phase I and Phase II topical reports titled Feasibility Study for Lowering the Minimum Gas Pressure in Solution-Mined Caverns Based on Geomechanical Analyses of Creep-Induced Damage and Healing.

  17. Prospects for the study of the {tau}-tilde system in SPS1a' at the ILC

    SciTech Connect (OSTI)

    Bechtle, Philip; Berggren, Mikael; List, Jenny; Schade, Peter; Stempel, Olga

    2010-09-01

    The prospects for the analysis of {tau} channels at the supersymmetry (SUSY) benchmark point SPS1a', especially from e{sup +}e{sup -{yields}{tau}}-tilde{sub 1}{sup +{tau}}-tilde{sub 1}{sup -} and e{sup +}e{sup -{yields}{tau}}-tilde{sub 2}{sup +{tau}}-tilde{sub 2}{sup -}, have been studied in full simulation of the ILD detector concept foreseen for the International Linear Collider. All accessible SUSY channels as well as all standard model backgrounds were generated at a center-of-mass energy E{sub CMS}=500 GeV, including the beam energy spectrum and beam backgrounds expected for nominal ILC beam parameters. With an integrated luminosity of 500 fb{sup -1} delivered to the experiment, the masses of the {tau}-tilde{sub 1} and {tau}-tilde{sub 2} can be measured to 107.73{sub -0.05}{sup +0.03} GeV{+-}1.1{center_dot}{delta}M{sub {chi}-}tilde{sub 1}{sup 0} and 183{sub -5}{sup +11} GeV{+-}18{center_dot}{delta}M{sub {chi}-}tilde{sub 1}{sup 0}, respectively, while the true values in SPS1a' are 107.9 GeV and 194.9 GeV, respectively. This corresponds to {delta}M{sub {tau}-}tilde{sub 1}/M{sub {tau}-}tilde{sub 1{approx}}0.1% and {delta}M{sub {tau}-}tilde{sub 2}/M{sub {tau}-}tilde{sub 2{approx}}3% with reasonable assumptions on {delta}M{sub {chi}-}tilde{sub 1}{sup 0}. The cross sections for {tau}-tilde{sub 1} and {tau}-tilde{sub 2} pair production could be obtained with a precision of 3.1% and 4.2%, respectively. Combining the mass and cross section measurement in the {tau}-tilde{sub 2} channel allows to determine the LSP mass with a relative error of 1.7%, assuming a known {tau}-tilde mixing angle. In {tau}-tilde{sub 1{yields}{tau}{chi}}-tilde{sub 1}{sup 0} decays, the {tau} polarization is measured to be 91{+-}9% and 86{+-}5% in the {pi} and {rho} decay channels of the {tau}, respectively. The true value in the simulated SPS1a' sample is 89.6%.

  18. EA-1750: Smart Grid, Center for Commercialization of Electric Technology, Technology Solutions for Wind Integration in ERCOT, Houston, Texas

    Broader source: Energy.gov [DOE]

    This EA evaluates the potential environmental impacts of providing a financial assistance grant under the American Recovery and Reinvestment Act of 2009 to the Center for Commercialization of Electric Technology to facilitate the development and demonstration of a multi-faceted, synergistic approach to managing fluctuations in wind power within the Electric Reliability Council of Texas transmission grid.

  19. Solar Resources Measurements in Houston, TX -- Equipment Only: Cooperative Research and Development Final Report, CRADA Number CRD-06-204

    SciTech Connect (OSTI)

    Stoffel, T.

    2012-09-01

    Loaning Texas Southern University equipment in order to perform site-specific, long-term, continuous, and high-resolution measurements of solar irradiance is important for developing renewable resource data. These data are used for several research and development activities consistent with the NREL mission: (1) establish a national 30-year climatological database of measured solar irradiances; (2) provide high quality ground-truth data for satellite remote sensing validation; (3) support development of radiative transfer models for estimating solar irradiance from available meteorological observations; (4) provide solar resource information needed for technology deployment and operations. Data acquired under this agreement will be available to the public through NREL's Measurement & Instrumentation Data Center - MIDC (http://www.nrel.gov/midc) Or the Renewable Resource Data Center - RReDC (http://rredc.nrel.gov). The MIDC offers a variety of standard data display, access, and analysis tools designed to address the needs of a wide user audience (e.g., industry, academia, and government interests).

  20. User`s manual for EROSION/MOD1: A computer program for fluids-solids erosion

    SciTech Connect (OSTI)

    Lyczkowski, R.W.; Bouillard, J.X.; Folga, S.M.; Chang, S.L.

    1992-09-01

    This report describes EROSION/MOD1, a computer program that was developed as a two-dimensional analytical tool for the general analysis of erosion in fluid-solids systems and the specific analysis of erosion in bubbling fluidized-bed combustors. Contained herein are implementations of Finnie`s impaction erosion model, Neilson and Gilchrist`s combined ductile and brittle erosion model, and several forms of the monolayer energy dissipation erosion model. These models and their implementations are described briefly. The global structure of EROSION/MOD1 that contains these models is also discussed. The input data for EROSION/MOD1 are given, and a sample problem for a fluidized bed is described. The hydrodynamic input data are assumed to come from the output of FLUFIX/MOD2.

  1. Analyzing the Levelized Cost of Centralized and Distributed Hydrogen Production Using the H2A Production Model, Version 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    267 September 2009 Analyzing the Levelized Cost of Centralized and Distributed Hydrogen Production Using the H2A Production Model, Version 2 T. Ramsden and D. Steward National Renewable Energy Laboratory J. Zuboy Independent Contractor National Renewable Energy Laboratory 1617 Cole Boulevard, Golden, Colorado 80401-3393 303-275-3000 * www.nrel.gov NREL is a national laboratory of the U.S. Department of Energy Office of Energy Efficiency and Renewable Energy Operated by the Alliance for

  2. The eukaryotic translation elongation factor eEF1A2 induces neoplastic properties and mediates tumorigenic effects of ZNF217 in precursor cells of human ovarian carcinomas

    SciTech Connect (OSTI)

    Sun, Yu; Wong, Nicholas; Guan, Yinghui; Salamanca, Clara M.; Cheng, Jung Chien; Lee, Jonathan M.; Gray, Joe W.; Auersperg, Nelly

    2008-04-25

    Ovarian epithelial carcinomas (OEC) frequently exhibit amplifications at the 20q13 locus which is the site of several oncogenes, including the eukaryotic elongation factor EEF1A2 and the transcription factor ZNF217. We reported previously that overexpressed ZNF217 induces neoplastic characteristics in precursor cells of OEC. Unexpectedly, ZNF217, which is a transcriptional repressor, enhanced expression of eEF1A2. In this study, array comparative genomic hybridization, single nucleotide polymorphism and Affymetrix analysis of ZNF217-overexpressing cell lines confirmed consistently increased expression of eEF1A2 but not of other oncogenes, and revealed early changes in EEF1A2 gene copy numbers and increased expression at crisis during immortalization. We defined the influence of eEF1A2 overexpression on immortalized ovarian surface epithelial cells, and investigated interrelationships between effects of ZNF217 and eEF1A2 on cellular phenotypes. Lentivirally induced eEF1A2 overexpression caused delayed crisis, apoptosis resistance and increases in serum-independence, saturation densities, and anchorage independence. siRNA to eEF1A2 reversed apoptosis resistance and reduced anchorage independence in eEF1A2-overexpressing lines. Remarkably, siRNA to eEF1A2 was equally efficient in inhibiting both anchorage independence and resistance to apoptosis conferred by ZNF217 overexpression. Our data define neoplastic properties that are caused by eEF1A2 in nontumorigenic ovarian cancer precursor cells, and suggest that eEF1A2 plays a role in mediating ZNF217-induced neoplastic progression.

  3. Evaluation of LLTR Series II tests A-1A and A-1B test results. [Large Leak Test Rig

    SciTech Connect (OSTI)

    Shoopak, B F; Amos, J C; Norvell, T J

    1980-03-01

    The standard methodology, with minor modifications provides conservative yet realistic predictions of leaksite and other sodium system pressures in the LLTR Series II vessel and piping. The good agreement between predicted and measured pressures indicates that the TRANSWRAP/RELAP modeling developed from the Series I tests is applicable to larger scale units prototypical of the Clinch River steam generator design. Calculated sodium system pressures are sensitive to several modeling parameters including rupture disc modeling, acoustic velocity in the test vessel, and flow rate from the rupture tube. The acoustic velocity which produced best agreement with leaksite pressures was calculated based on the shroud diameter and shroud wall thickness. The corresponding rupture tube discharge coefficient was that of the standard design methodology developed from Series I testing. As found in Series I testing, the Series II data suggests that the leading edge of the flow in the relief line is two phase for a single, doubled-ended guillotine tube rupture. The steam generator shroud acts as if it is relatively transparent to the transmission of radial pressures to the vessel wall. Slightly lower sodium system maximum pressures measured during Test A-1b compared to Test A-1a are attributed to premature failure (failure at a lower pressure) of the rupture disc in contact with the sodium for test A-1b. The delay in failure of the second disc in Test A-1b, which was successfully modeled with TRANSWRAP, is attributed to the limited energy in the nitrogen injection.

  4. U.S. gasoline price expected to average less than $2 a gallon both this year and next

    U.S. Energy Information Administration (EIA) Indexed Site

    U.S. gasoline price expected to average less than $2 a gallon both this year and next U.S. drivers are now expected to see back-to-back years of annual average gasoline prices below $2 per gallon for the first time in more than a decade. In its latest monthly forecast, the U.S. Energy Information Administration said low oil prices will keep the average annual price for a gallon of regular-grade gasoline at $1.89 this year and at $1.97 in 2017. The last time gasoline averaged less than $2 for two

  5. Guidance document for revision of DOE Order 5820.2A, Radioactive Waste Technical Support Program. Revision 1

    SciTech Connect (OSTI)

    Kudera, D.E.; McMurtrey, C.D.; Meagher, B.G.

    1993-04-01

    This document provides guidance for the revision of DOE Order 5820.2A, ``Radioactive Waste Management.`` Technical Working Groups have been established and are responsible for writing the revised order. The Technical Working Groups will use this document as a reference for polices and procedures that have been established for the revision process. The overall intent of this guidance is to outline how the order will be revised and how the revision process will be managed. In addition, this document outlines technical issues considered for inclusion by a Department of Energy Steering Committee.

  6. The upstream open reading frame of cyclin-dependent kinase inhibitor 1A mRNA negatively regulates translation of the downstream main open reading frame

    SciTech Connect (OSTI)

    Kim, Kyoung Mi; Cho, Hana; Kim, Yoon Ki

    2012-08-03

    Highlights: Black-Right-Pointing-Pointer CDKN1A mRNA is a bona fide NMD substrate. Black-Right-Pointing-Pointer The uORF of CDKN1A mRNA is efficiently translated. Black-Right-Pointing-Pointer Translation of downstream main ORF is negatively regulated by translation of uORF in CDKN1A mRNA. -- Abstract: The first round of translation occurs on mRNAs bound by nuclear cap-binding complex (CBC), which is composed of nuclear cap-binding protein 80 and 20 (CBP80/20). During this round of translation, aberrant mRNAs are recognized and downregulated in abundance by nonsense-mediated mRNA decay (NMD), which is one of the mRNA quality control mechanisms. Here, our microarray analysis reveals that the level of cyclin-dependent kinase inhibitor 1A (CDKN1A; also known as Waf1/p21) mRNAs increases in cells depleted of cellular NMD factors. Intriguingly, CDKN1A mRNA contains an upstream open reading frame (uORF), which is a NMD-inducing feature. Using chimeric reporter constructs, we find that the uORF of CDKN1A mRNA negatively modulates translation of the main downstream ORF. These findings provide biological insights into the possible role of NMD in diverse biological pathways mediated by CDKN1A.

  7. A method distinguishing expressed vs. null mutations of the Col1A1 gene in osteogenesis imperfecta

    SciTech Connect (OSTI)

    Redford-Badwal, D.A.; Stover, M.L.; McKinstry, M.

    1994-09-01

    Osteogenesis imperfecta (OI) is a heterogeneous group of heritable disorders of bone characterized by increased susceptibility to fracture. Most of the causative mutations were identified in patients with the lethal form of the disease. Attention is now shifting to the milder forms of OI where glycine substitutions and null producing mutations have been found. Single amino acid substitutions can be identified by RT/PCR of total cellular RNA, but this approach does not work well for null mutations since the defective transcript does not accumulate in the cytoplasm. We have altered our RNA extraction method to separate RNA from the nuclear and cytoplasmic compartments of cultured fibroblasts. Standard methods of mutation identification (RT/PCR followed by SSCP) is applied to each RNA fraction. DNA from an abnormal band on the SSCP gel is eluted and amplified by PCR for cloning and sequencing. Using this approach we have identified an Asp to Asn change in exon 50 (type II OI) and a Gly to Arg in exon 11 (type I OI) of the COL1A1 gene. These changes were found in both nuclear and cytoplasmic compartments. These putative mutations are currently being confirmed by protein studies. In contrast, three patients with mild OI associated with reduced {proportional_to}(I)mRNA, had distinguishing SSCP bands present in the nuclear but not the cytoplasmic compartment. In one case a frame shift mutation was observed, while the other two revealed polymorphisms. The compartmentalization of the mutant allele has directed us to look elsewhere in the transcript for the causative mutation. This approach to mutation identification is capable of distinguishing these fundamentally different types of mutations and allows for preferential cloning and sequencing of the abnormal allele.

  8. Development of the scintillator-based probe for fast-ion losses in the HL-2A tokamak

    SciTech Connect (OSTI)

    Zhang, Y. P. Liu, Yi; Yuan, G. L.; Song, X. Y.; Yang, J. W.; Li, X.; Chen, W.; Li, Y.; Yan, L. W.; Song, X. M.; Yang, Q. W.; Duan, X. R.; Luo, X. B.; Liu, Y. Q.; Hua, Y.; Isobe, M.

    2014-05-15

    A new scintillator-based lost fast-ion probe (SLIP) has been developed and operated in the HL-2A tokamak [L. W. Yan, X. R. Duan, X. T. Ding, J. Q. Dong, Q. W. Yang, Yi Liu, X. L. Zou, D. Q. Liu, W. M. Xuan, L. Y. Chen, J. Rao, X. M. Song, Y. Huang, W. C. Mao, Q. M. Wang, Q. Li, Z. Cao, B. Li, J. Y. Cao, G. J. Lei, J. H. Zhang, X. D. Li, W. Chen, J. Chen, C. H. Cui, Z. Y. Cui, Z. C. Deng, Y. B. Dong, B. B. Feng, Q. D. Gao, X. Y. Han, W. Y. Hong, M. Huang, X. Q. Ji, Z. H. Kang, D. F. Kong, T. Lan, G. S. Li, H. J. Li, Qing Li, W. Li, Y. G. Li, A. D. Liu, Z. T. Liu, C. W. Luo, X. H. Mao, Y. D. Pan, J. F. Peng, Z. B. Shi, S. D. Song, X. Y. Song, H. J. Sun, A. K. Wang, M. X. Wang, Y. Q. Wang, W. W. Xiao, Y. F. Xie, L. H. Yao, D. L. Yu, B. S. Yuan, K. J. Zhao, G. W. Zhong, J. Zhou, J. C. Yan, C. X. Yu, C. H. Pan, Y. Liu, and the HL-2A Team , Nucl. Fusion 51, 094016 (2011)] to measure the losses of neutral beam ions. The design of the probe is based on the concept of the ?-particle detectors on Tokamak Fusion Test Reactor (TFTR) using scintillator plates. The probe is capable of traveling across an equatorial plane port and sweeping the aperture angle rotationally with respect to the axis of the probe shaft by two step motors, in order to optimize the radial position and the collimator angle. The energy and the pitch angle of the lost fast ions can be simultaneously measured if the two-dimensional image of scintillation light intensity due to the impact of the lost fast ions is detected. Measurements of the fast-ion losses using the probe have been performed during HL-2A neutral beam injection discharges. The clear experimental evidence of enhanced losses of beam ions during disruptions has been obtained by means of the SLIP system. A detailed description of the probe system and the first experimental results are reported.

  9. Inter- and Intrafraction Target Motion in Highly Focused Single Vocal Cord Irradiation of T1a Larynx Cancer Patients

    SciTech Connect (OSTI)

    Kwa, Stefan L.S. Al-Mamgani, Abrahim; Osman, Sarah O.S.; Gangsaas, Anne; Levendag, Peter C.; Heijmen, Ben J.M.

    2015-09-01

    Purpose: The purpose of this study was to verify clinical target volume–planning target volume (CTV-PTV) margins in single vocal cord irradiation (SVCI) of T1a larynx tumors and characterize inter- and intrafraction target motion. Methods and Materials: For 42 patients, a single vocal cord was irradiated using intensity modulated radiation therapy at a total dose of 58.1 Gy (16 fractions × 3.63 Gy). A daily cone beam computed tomography (CBCT) scan was performed to online correct the setup of the thyroid cartilage after patient positioning with in-room lasers (interfraction motion correction). To monitor intrafraction motion, CBCT scans were also acquired just after patient repositioning and after dose delivery. A mixed online-offline setup correction protocol (“O2 protocol”) was designed to compensate for both inter- and intrafraction motion. Results: Observed interfraction, systematic (Σ), and random (σ) setup errors in left-right (LR), craniocaudal (CC), and anteroposterior (AP) directions were 0.9, 2.0, and 1.1 mm and 1.0, 1.6, and 1.0 mm, respectively. After correction of these errors, the following intrafraction movements derived from the CBCT acquired after dose delivery were: Σ = 0.4, 1.3, and 0.7 mm, and σ = 0.8, 1.4, and 0.8 mm. More than half of the patients showed a systematic non-zero intrafraction shift in target position, (ie, the mean intrafraction displacement over the treatment fractions was statistically significantly different from zero; P<.05). With the applied CTV-PTV margins (for most patients 3, 5, and 3 mm in LR, CC, and AP directions, respectively), the minimum CTV dose, estimated from the target displacements observed in the last CBCT, was at least 94% of the prescribed dose for all patients and more than 98% for most patients (37 of 42). The proposed O2 protocol could effectively reduce the systematic intrafraction errors observed after dose delivery to almost zero (Σ = 0.1, 0.2, 0.2 mm). Conclusions: With

  10. Ab initio energies and tunneling lifetimes of the doubly charged AH{sup 2+} (A = Mg-Ar) diatomics

    SciTech Connect (OSTI)

    Nefedova, V.V.; Boldyrev, A.I.; Simons, J.

    1995-09-15

    Potential energy curves for the ground and low-lying excited states of the AH{sup 2+} (A = Mg-Ar) dications have been calculated using high-level ab initio methods with large atomic orbital basis sets. Quasi-bound potential energy curves with local minima and deprotonation barriers have been found for most of the dications studied. The energies, tunneling lifetimes, and widths of the quasi-bound states have been calculated by numerical solution of the radial Schroedinger equation using the Numeov method. All these dications except ArH{sup 2+} have low-lying states which support quasi-bound vibrational states. The ArH{sup 2+} dication has a {sup 2}{Pi}{sub i} potential energy curve with a minimum so shallow that it does not support any quasi-bound vibrational states. Results of our calculations are compared with previous ab initio calculations and available experimental data. 24 refs., 8 figs., 12 tabs.

  11. PTF1 J191905.19+481506.2A partially eclipsing AM CVn system discovered in the Palomar transient factory

    SciTech Connect (OSTI)

    Levitan, David; Groot, Paul J.; Prince, Thomas A.; Kulkarni, Shrinivas R.; Hallinan, Gregg; Harding, Leon K.; Sesar, Branimir; Kupfer, Thomas; Kyne, Gillian; Laher, Russ; Surace, Jason; Ofek, Eran O.; Rutten, Ren G. M.

    2014-04-20

    We report on PTF1 J191905.19+481506.2, a newly discovered, partially eclipsing, outbursting AM CVn system found in the Palomar Transient Factory synoptic survey. This is only the second known eclipsing AM CVn system. We use high-speed photometric observations and phase-resolved spectroscopy to establish an orbital period of 22.4559(3) minutes. We also present a long-term light curve and report on the normal and super-outbursts regularly seen in this system, including a super-outburst recurrence time of 36.8(4) days. We use the presence of the eclipse to place upper and lower limits on the inclination of the system and discuss the number of known eclipsing AM CVn systems versus what would be expected.

  12. Liver X receptor alpha mediated genistein induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1) in Hep G2 cells

    SciTech Connect (OSTI)

    Chen, Yue; Zhang, Shunfen; Zhou, Tianyan; Huang, Chaoqun; McLaughlin, Alicia; Chen, Guangping

    2013-04-15

    Cytosolic sulfotransferases are one of the major families of phase II drug metabolizing enzymes. Sulfotransferase-catalyzed sulfonation regulates hormone activities, metabolizes drugs, detoxifies xenobiotics, and bioactivates carcinogens. Human dehydroepiandrosterone sulfotransferase (hSULT2A1) plays important biological roles by sulfating endogenous hydroxysteroids and exogenous xenobiotics. Genistein, mainly existing in soy food products, is a naturally occurring phytoestrogen with both chemopreventive and chemotherapeutic potential. Our previous studies have shown that genistein significantly induces hSULT2A1 in Hep G2 and Caco-2 cells. In this study, we investigated the roles of liver X receptor (LXRα) in the genistein induction of hSULT2A1. LXRs have been shown to induce expression of mouse Sult2a9 and hSULT2A1 gene. Our results demonstrate that LXRα mediates the genistein induction of hSULT2A1, supported by Western blot analysis results, hSULT2A1 promoter driven luciferase reporter gene assay results, and mRNA interference results. Chromatin immunoprecipitation (ChIP) assay results demonstrate that genistein increase the recruitment of hLXRα binding to the hSULT2A1 promoter. These results suggest that hLXRα plays an important role in the hSULT2A1 gene regulation. The biological functions of phytoestrogens may partially relate to their induction activity toward hydroxysteroid SULT. - Highlights: ► Liver X receptor α mediated genistein induction of hSULT2A1 in Hep G2 cells. ► LXRα and RXRα dimerization further activated this induction. ► Western blot results agreed well with luciferase reporter gene assay results. ► LXRs gene silencing significantly decreased hSULT2A1 expression. ► ChIP analysis suggested that genistein enhances hLXRα binding to the hSULT2A1 promoter.

  13. Sample Business Plan Framework 1: A program seeking to continue operations in the post-grant period as a not-for-profit (NGO) entity

    Broader source: Energy.gov [DOE]

    U.S. Department of Energy Better Buildings Neighborhood Program: Sample Business Plan Framework 1: A program seeking to continue operations in the post-grant period as a not-for-profit (NGO) entity.

  14. Genetic variation in the CYP1A1 gene is related to circulating PCB118 levels in a population-based sample

    SciTech Connect (OSTI)

    Lind, Lars; Penell, Johanna; Syvänen, Anne-Christine; Axelsson, Tomas; Ingelsson, Erik; Morris, Andrew P.; Lindgren, Cecilia; Salihovic, Samira; Bavel, Bert van; Lind, P. Monica

    2014-08-15

    Several of the polychlorinated biphenyls (PCBs), i.e. the dioxin-like PCBs, are known to induce the P450 enzymes CYP1A1, CYP1A2 and CYP1B1 by activating the aryl hydrocarbon receptor (Ah)-receptor. We evaluated if circulating levels of PCBs in a population sample were related to genetic variation in the genes encoding these CYPs. In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (1016 subjects all aged 70), 21 SNPs in the CYP1A1, CYP1A2 and CYP1B1 genes were genotyped. Sixteen PCB congeners were analysed by high-resolution chromatography coupled to high-resolution mass spectrometry (HRGC/ HRMS). Of the investigated relationships between SNPs in the CYP1A1, CYP1A2 and CYP1B1 and six PCBs (congeners 118, 126, 156, 169, 170 and 206) that captures >80% of the variation of all PCBs measured, only the relationship between CYP1A1 rs2470893 was significantly related to PCB118 levels following strict adjustment for multiple testing (p=0.00011). However, there were several additional SNPs in the CYP1A2 and CYP1B1 that showed nominally significant associations with PCB118 levels (p-values in the 0.003–0.05 range). Further, several SNPs in the CYP1B1 gene were related to both PCB156 and PCB206 with p-values in the 0.005–0.05 range. Very few associations with p<0.05 were seen for PCB126, PCB169 or PCB170. Genetic variation in the CYP1A1 was related to circulating PCB118 levels in the general elderly population. Genetic variation in CYP1A2 and CYP1B1 might also be associated with other PCBs. - Highlights: • We studied the relationship between PCBs and the genetic variation in the CYP genes. • Cross sectional data from a cohort of elderly were analysed. • The PCB levels were evaluated versus 21 SNPs in three CYP genes. • PCB 118 was related to variation in the CYP1A1 gene.

  15. Preclinical pharmacology and toxicology study of Ad-hTERT-E1a-Apoptin, a novel dual cancer-specific oncolytic adenovirus

    SciTech Connect (OSTI)

    Qi, Yanxin; Guo, Huanhuan; Hu, Ningning; He, Dongyun; Zhang, Shi; Chu, Yunjie; Huang, Yubin; Li, Xiao; Sun, LiLi; Jin, Ningyi

    2014-10-15

    Clinical studies have demonstrated that conditionally replicating adenovirus is safe. We constructed an oncolytic adenovirus, Ad-hTERT-E1a-Apoptin, using a cancer-specific promoter (human telomerase reverse transcriptase promoter, hTERTp) and a cancer cell-selective apoptosis-inducing gene (Apoptin). Ad-hTERT-E1a-Apoptin was proven effective both in vitro and in vivo in our previous study. In this study, the preclinical safety profiles of Ad-hTERT-E1a-Apoptin in animal models were investigated. At doses of 5.0 × 10{sup 8}, 2.5 × 10{sup 9}, and 1.25 × 10{sup 10} viral particles (VP)/kg, Ad-hTERT-E1a-Apoptin had no adverse effects on mouse behavior, muscle cooperation, sedative effect, digestive system, and nervous systems, or on beagle cardiovascular and respiratory systems at 5.0 × 10{sup 8}, 2.5 × 10{sup 9}, and 1.25 × 10{sup 10} VP/kg doses. In acute toxicity tests in mice, the maximum tolerated dose > 5 × 10{sup 10} VP/kg. There was no inflammation or ulceration at the injection sites within two weeks. In repeat-dose toxicological studies, the no observable adverse effect levels of Ad-hTERT-E1a-Apoptin in rats (1.25 × 10{sup 10} VP/kg) and beagles (2.5 × 10{sup 9} VP/kg) were 62.5- and 12.5-fold of the proposed clinical dose, respectively. The anti-virus antibody was produced in animal sera. Bone marrow examination revealed no histopathological changes. Guinea pigs sensitized by three repeated intraperitoneal injections of 1.35 × 10{sup 10} VP/mL Ad-hTERT-E1a-Apoptin each and challenged by one intravenous injection of 1.67 × 10{sup 8} VP/kg Ad-hTERT-E1a-Apoptin did not exhibit any sign of systemic anaphylaxis. Our data from different animal models suggest that Ad-hTERT-E1a-Apoptin is a safe anti-tumor therapeutic agent. - Highlights: • We use the rodents and non-rodents animal models to evaluation Ad-hTERT-E1a-Apoptin. • Ad-hTERT-E1a-Apoptin is a safe anti-tumor therapeutic agent. • Demonstrate the safety and feasibility dose of injected Ad

  16. Caffeic acid phenethyl ester inhibits 3-MC-induced CYP1A1 expression through induction of hypoxia-inducible factor-1α

    SciTech Connect (OSTI)

    Kim, Hyung Gyun; Han, Eun Hee; Im, Ji Hye; Lee, Eun Ji; Jin, Sun Woo; Jeong, Hye Gwang

    2015-09-25

    Caffeic acid phenethyl ester (CAPE), a natural component of propolis, is reported to have anticarcinogenic properties, although its precise chemopreventive mechanism remains unclear. In this study, we examined the effects of CAPE on 3-methylcholanthrene (3-MC)-induced CYP1A1 expression and activities. CAPE reduced the formation of the benzo[a]pyrene-DNA adduct. Moreover, CAPE inhibited 3-MC-induced CYP1A1 activity, mRNA expression, protein level, and promoter activity. CAPE treatment also decreased 3-MC-inducible xenobiotic-response element (XRE)-linked luciferase, aryl hydrocarbons receptor (AhR) transactivation and nuclear localization. CAPE induced hypoxia inducible factor-1α (HIF-1α) protein level and HIF-1α responsible element (HRE) transcriptional activity. CAPE-mediated HIF-1α reduced 3-MC-inducible CYP1A1 protein expression. Taken together, CAPE decreases 3-MC-mediated CYP1A1 expression, and this inhibitory response is associated with inhibition of AhR and HIF-1α induction. - Highlights: • CAPE reduced the formation of the benzo[a]pyrene-DNA adduct. • CAPE inhibited 3-MC-induced CYP1A1 expression. • CAPE induced HIF-1α induction. • CAPE-mediated HIF-1α reduced 3-MC-inducible CYP1A1 expression.

  17. Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating aryl hydrocarbon receptor expression

    SciTech Connect (OSTI)

    Do, Minh Truong; Kim, Hyung Gyun; Tran, Thi Thu Phuong; Khanal, Tilak; Choi, Jae Ho; Chung, Young Chul; Jeong, Tae Cheon; Jeong, Hye Gwang

    2014-10-01

    Induction of cytochrome P450 (CYP) 1A1 and CYP1B1 by environmental xenobiotic chemicals or endogenous ligands through the activation of the aryl hydrocarbon receptor (AhR) has been implicated in a variety of cellular processes related to cancer, such as transformation and tumorigenesis. Here, we investigated the effects of the anti-diabetes drug metformin on expression of CYP1A1 and CYP1B1 in breast cancer cells under constitutive and inducible conditions. Our results indicated that metformin down-regulated the expression of CYP1A1 and CYP1B1 in breast cancer cells under constitutive and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced conditions. Down-regulation of AhR expression was required for metformin-mediated decreases in CYP1A1 and CYP1B1 expression, and the metformin-mediated CYP1A1 and CYP1B1 reduction is irrelevant to estrogen receptor α (ERα) signaling. Furthermore, we found that metformin markedly down-regulated Sp1 protein levels in breast cancer cells. The use of genetic and pharmacological tools revealed that metformin-mediated down-regulation of AhR expression was mediated through the reduction of Sp1 protein. Metformin inhibited endogenous AhR ligand-induced CYP1A1 and CYP1B1 expression by suppressing tryptophan-2,3-dioxygenase (TDO) expression in MCF-7 cells. Finally, metformin inhibits TDO expression through a down-regulation of Sp1 and glucocorticoid receptor (GR) protein levels. Our findings demonstrate that metformin reduces CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating AhR signaling. Metformin would be able to act as a potential chemopreventive agent against CYP1A1 and CYP1B1-mediated carcinogenesis and development of cancer. - Graphical abstract: Schematic of the CYP1A1 and CYP1B1 gene regulation by metformin. - Highlights: • Metformin inhibits CYP1A1 and CYP1B1 expression. • Metformin down-regulates the AhR signaling. • Metformin reduces Sp1 protein expression. • Metformin suppresses TDO expression.

  18. Reactions of C{sub 2}(a {sup 3} product {sub u}) with selected saturated alkanes: A temperature dependence study

    SciTech Connect (OSTI)

    Hu Renzhi; Zhang Qun; Chen Yang

    2010-04-28

    We present a temperature dependence study on the gas phase reactions of the C{sub 2}(a {sup 3} product {sub u}) radical with a selected series of saturated alkanes (C{sub 2}H{sub 6}, C{sub 3}H{sub 8}, n-C{sub 4}H{sub 10}, i-C{sub 4}H{sub 10}, and n-C{sub 6}H{sub 14}) by means of pulsed laser photolysis/laser-induced fluorescence technique. The bimolecular rate constants for these reactions were obtained between 298 and 673 K. A pronounced negative temperature effect was observed for n-C{sub 4}H{sub 10}, i-C{sub 4}H{sub 10}, and n-C{sub 6}H{sub 14} and interpreted in terms of steric hindrance of the more reactive secondary or tertiary C-H bonds by less reactive CH{sub 3} groups. Detailed analysis of our experimental results reveals quantitatively the temperature dependence of reactivities for the primary, secondary, and tertiary C-H bonds in these saturated alkanes and further lends support to a mechanism of hydrogen abstraction.

  19. TRAC-PF1/MOD1 independent assessment: Semiscale Mod-2A intermediate break test S-IB-3

    SciTech Connect (OSTI)

    Kmetyk, L N

    1986-02-01

    The TRAC-PF1/MOD1 independent assessment project at Sandia National Laboratories is part of an overall effort funded by the NRC to determine the ability of various system codes to predict the detailed thermal/hydraulic response of light water reactors during accident and off-normal conditions. The TRAC code is being assessed at SNLA against test data from various integral and separate effects test facilities. As part of this assessment matrix, an intermediate break test (S-IB-3), performed at the Semiscale Mod-2A facility, has been analyzed. Using an input model with a 3-D VESSEL component, the vessel and downcomer inventories during 3-IB-3 were generally well predicted, but the core heatup was underpredicted compared to data. An equivalent calculation with an all 1-D input model ran about twice as fast as our basecase analysis using a 3-D VESSEL in the input model, but the results of the two calculations diverged significantly for many parameters of interest, with the 3-D VESSEL model results in better agreement with data. 22 refs., 100 figs.

  20. Monolayer PtSe 2 , a New Semiconducting Transition-Metal-Dichalcogenide, Epitaxially Grown by Direct Selenization of Pt

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Wang, Yeliang; Li, Linfei; Yao, Wei; Song, Shiru; Sun, J. T.; Pan, Jinbo; Ren, Xiao; Li, Chen; Okunishi, Eiji; Wang, Yu-Qi; et al

    2015-05-21

    For single-layer transition-metal dichalcogenides (TMDs) receive significant attention due to their intriguing physical properties for both fundamental research and potential applications in electronics, optoelectronics, spintronics, catalysis, and so on. Here, we demonstrate the epitaxial growth of high-quality single-crystal, monolayer platinum diselenide (PtSe2), a new member of the layered TMDs family, by a single step of direct selenization of a Pt(111) substrate. We found that a combination of atomic-resolution experimental characterizations and first-principle theoretic calculations reveals the atomic structure of the monolayer PtSe2/Pt(111). Angle-resolved photoemission spectroscopy measurements confirm for the first time the semiconducting electronic structure of monolayer PtSe2 (in contrastmore » to its semimetallic bulk counterpart). The photocatalytic activity of monolayer PtSe2 film is evaluated by a methylene-blue photodegradation experiment, demonstrating its practical application as a promising photocatalyst. Moreover, circular polarization calculations predict that monolayer PtSe2 has also potential applications in valleytronics.« less

  1. Impact of purification conditions and history on A2A adenosine receptor activity: The role of CHAPS and lipids

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Naranjo, Andrea N.; McNeely, Patrick M.; Katsaras, John; Skaja Robinson, Anne

    2016-05-27

    The adenosine A2A receptor (A2AR) is a much-studied class A G protein-coupled receptor (GPCR). For biophysical studies, A2AR is commonly purified in a detergent mixture of dodecylmaltoside (DDM), 3-(3-cholamidopropyl) dimethylammoniopropane sulfonate (CHAPS), and cholesteryl hemisuccinate (CHS). Here we studied the effects of CHAPS on the ligand binding activity and stability of wild type, full-length human A2AR. We also tested the cholesterol requirement for maintaining the active conformation of the receptor when solubilized in detergent micelles. To this end, the receptor was purified using DDM, DDM/CHAPS, or the short hydrocarbon chain lipid 1,2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC, di-6:0PC). After solubilization in DDM, DDM/CHAPS, ormore » DHPC micelles, although A2AR was found to retain its native-like fold, its binding ability was significantly compromised compared to DDM or DDM/CHAPS with CHS. It therefore appears that although cholesterol is not needed for A2AR to retain a native-like, α-helical conformation, it may be a critical component for high affinity ligand binding. Further, this result suggests that the conformational differences between the active and inactive protein may be so subtle that commonly used spectroscopic methods are unable to differentiate between the two forms, highlighting the need for activity measurements. Furthermore, the studies presented in this paper also underline the importance of the protein’s purification history; i.e., detergents that interact with the protein during purification affect the ligand binding properties of the receptor in an irreversible manner.« less

  2. CX-000420: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Characterization of the Triassic Newark Basin of New York and New Jersey for Geologic Storage of Carbon DioxideCX(s) Applied: B3.1, A9Date: 12/11/2009Location(s): Houston, TexasOffice(s): Fossil Energy, National Energy Technology Laboratory

  3. CX-000421: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Characterization of the Triassic Newark Basin of New York and New Jersey for Geologic Storage of Carbon DioxideCX(s) Applied: B3.1, A9Date: 12/11/2009Location(s): Houston, TexasOffice(s): Fossil Energy, National Energy Technology Laboratory

  4. Sulforaphane inhibits CYP1A1 activity and promotes genotoxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro

    SciTech Connect (OSTI)

    Yang, Fangxing; Zhuang, Shulin; Zhang, Chao; Dai, Heping; Liu, Weiping

    2013-06-15

    Increasing environmental pollution by carcinogens such as some of persistent organic pollutants (POPs) has prompted growing interest in searching for chemopreventive compounds which are readily obtainable. Sulforaphane (SFN) is isolated from cruciferous vegetables and has the potentials to reduce carcinogenesis through various pathways. In this study, we studied the effects of SFN on CYP1A1 activity and genotoxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The results showed that SFN inhibited TCDD-induced CYP1A1 activity in H4IIE cells by directly inhibiting CYP1A1 activity, probably through binding to aryl hydrocarbon receptor and/or CYP1A1 revealed by molecular docking. However, SFN promoted TCDD-induced DNA damage in yeast cells and reduced the viability of initiated yeast cells. Besides, it is surprising that SFN also failed to reduce genotoxicity induced by other genotoxic reagents which possess different mechanisms to lead to DNA damage. Currently, it is difficult to predict whether SFN has the potentials to reduce the risk of TCDD based on the conflicting observations in the study. Therefore, further studies should be urgent to reveal the function and mechanism of SFN in the stress of such POPs on human health. - Highlights: Sulforaphane inhibited TCDD-induced CYP1A1 activity in H4IIE cells. Sulforaphane may bind to aryl hydrocarbon receptor and/or CYP1A1. Sulforaphane promoted TCDD-induced DNA damage in yeast cells. Sulforaphane may promote DNA damage by DNA strand breaks or DNA alkylation.

  5. HTR-PROTEUS Pebble Bed Experimental Program Cores 1, 1A, 2, and 3: Hexagonal Close Packing with a 1:2 Moderator-to-Fuel Pebble Ratio

    SciTech Connect (OSTI)

    John D. Bess; Barbara H. Dolphin; James W. Sterbentz; Luka Snoj; Igor Lengar; Oliver Köberl

    2013-03-01

    In its deployment as a pebble bed reactor (PBR) critical facility from 1992 to 1996, the PROTEUS facility was designated as HTR-PROTEUS. This experimental program was performed as part of an International Atomic Energy Agency (IAEA) Coordinated Research Project (CRP) on the Validation of Safety Related Physics Calculations for Low Enriched HTGRs. Within this project, critical experiments were conducted for graphite moderated LEU systems to determine core reactivity, flux and power profiles, reaction-rate ratios, the worth of control rods, both in-core and reflector based, the worth of burnable poisons, kinetic parameters, and the effects of moisture ingress on these parameters. Four benchmark experiments were evaluated in this report: Cores 1, 1A, 2, and 3. These core configurations represent the hexagonal close packing (HCP) configurations of the HTR-PROTEUS experiment with a moderator-to-fuel pebble ratio of 1:2. Core 1 represents the only configuration utilizing ZEBRA control rods. Cores 1A, 2, and 3 use withdrawable, hollow, stainless steel control rods. Cores 1 and 1A are similar except for the use of different control rods; Core 1A also has one less layer of pebbles (21 layers instead of 22). Core 2 retains the first 16 layers of pebbles from Cores 1 and 1A and has 16 layers of moderator pebbles stacked above the fueled layers. Core 3 retains the first 17 layers of pebbles but has polyethylene rods inserted between pebbles to simulate water ingress. The additional partial pebble layer (layer 18) for Core 3 was not included as it was used for core operations and not the reported critical configuration. Cores 1, 1A, 2, and 3 were determined to be acceptable benchmark experiments.

  6. HTR-PROTEUS Pebble Bed Experimental Program Cores 1, 1A, 2, and 3: Hexagonal Close Packing with a 1:2 Moderator-to-Fuel Pebble Ratio

    SciTech Connect (OSTI)

    John D. Bess; Barbara H. Dolphin; James W. Sterbentz; Luka Snoj; Igor Lengar; Oliver Köberl

    2012-03-01

    In its deployment as a pebble bed reactor (PBR) critical facility from 1992 to 1996, the PROTEUS facility was designated as HTR-PROTEUS. This experimental program was performed as part of an International Atomic Energy Agency (IAEA) Coordinated Research Project (CRP) on the Validation of Safety Related Physics Calculations for Low Enriched HTGRs. Within this project, critical experiments were conducted for graphite moderated LEU systems to determine core reactivity, flux and power profiles, reaction-rate ratios, the worth of control rods, both in-core and reflector based, the worth of burnable poisons, kinetic parameters, and the effects of moisture ingress on these parameters. Four benchmark experiments were evaluated in this report: Cores 1, 1A, 2, and 3. These core configurations represent the hexagonal close packing (HCP) configurations of the HTR-PROTEUS experiment with a moderator-to-fuel pebble ratio of 1:2. Core 1 represents the only configuration utilizing ZEBRA control rods. Cores 1A, 2, and 3 use withdrawable, hollow, stainless steel control rods. Cores 1 and 1A are similar except for the use of different control rods; Core 1A also has one less layer of pebbles (21 layers instead of 22). Core 2 retains the first 16 layers of pebbles from Cores 1 and 1A and has 16 layers of moderator pebbles stacked above the fueled layers. Core 3 retains the first 17 layers of pebbles but has polyethylene rods inserted between pebbles to simulate water ingress. The additional partial pebble layer (layer 18) for Core 3 was not included as it was used for core operations and not the reported critical configuration. Cores 1, 1A, 2, and 3 were determined to be acceptable benchmark experiments.

  7. THE VLA NASCENT DISK AND MULTIPLICITY (VANDAM) SURVEY OF PERSEUS PROTOSTARS. RESOLVING THE SUB-ARCSECOND BINARY SYSTEM IN NGC1333 IRAS2A

    SciTech Connect (OSTI)

    Tobin, John J.; Looney, Leslie W.; Dunham, Michael M.; Li, Zhi-Yun; Chandler, Claire J.; Perez, Laura M.; Segura-Cox, Dominique; Harris, Robert J.; Hull, Charles L. H.; Sadavoy, Sarah I.; Melis, Carl; Kratter, Kaitlin; Jrgensen, Jes K.; Plunkett, Adele L. E-mail: jeskj@nbi.dk

    2015-01-01

    We are conducting a Jansky Very Large Array (VLA) Ka-band (8mm and 1 cm) and C-band (4cm and 6.4cm) survey of all known protostars in the Perseus Molecular Cloud, providing resolution down to ?0.''06 and ?0.''35 in the Ka band and C band, respectively. Here we present first results from this survey that enable us to examine the source NGC1333 IRAS2A in unprecedented detail and resolve it into a protobinary system separated by 0.''621 0.''006 (?143 AU) at 8mm, 1cm, and 4cm. These two sources (IRAS2A VLA1 and VLA2) are likely driving the two orthogonal outflows known to originate from IRAS2A. The brighter source IRAS2A VLA1 is extended perpendicular to its outflow in the VLA data, with a deconvolved size of 0.''055 (?13 AU), possibly tracing a protostellar disk. The recently reported candidate companions (IRAS2A MM2 and MM3) are not detected in either our VLA data, Combined Array for Research in Millimeter-wave Astronomy (CARMA) 1.3mm data, or Submillimeter Array (SMA) 850 ?m data. SMA CO (J = 3 ? 2), CARMA CO (J = 2 ? 1), and lower-resolution CARMA CO (J = 1 ? 0) observations are used to examine the outflow origins and the nature of the candidate companions to IRAS2A VLA1. The CO (J = 3 ? 2) and (J = 2 ? 1) data show that IRAS2A MM2 is coincident with a bright CO emission spot in the east-west outflow, and IRAS2A MM3 is within the north-south outflow. In contrast, IRAS2A VLA2 lies at the east-west outflow symmetry point. We propose that IRAS2A VLA2 is the driving source of the east-west outflow and a true companion to IRAS2A VLA1, whereas IRAS2A MM2 and MM3 may not be protostellar.

  8. Single Use Letter Report for the Verification and Validation of the RADNUC-2A and ORIGEN2 S.2 Computer Codes

    SciTech Connect (OSTI)

    PACKER, M.J.

    2000-06-20

    This report documents the verification and validation (V&V) activities undertaken to support the use of the RADNUC2-A and ORIGEN2 S.2 computer codes for the specific application of calculating isotopic inventories and decay heat loadings for Spent Nuclear Fuel Project (SNFP) activities as described herein. Two recent applications include the reports HNF-SD-SNF-TI-009, 105-K Basin Material Design Basis Feed Description for Spent Nuclear Fuel Project Facilities, Volume 1, Fuel (Praga, 1998), and HNF-3035, Rev. 0B, MCO Gas Composition for Low Reactive Surface Areas (Packer, 1998). Representative calculations documented in these two reports were repeated using RADNUC2-A, and the results were identical to the documented results. This serves as verification that version 2A of Radnuc was used for the applications noted above; the same version was tested herein, and perfect agreement was shown. Comprehensive V&V is demonstrated for RADNUC2-A in Appendix A.

  9. Order Module--DOE O 460.1C, PACKAGING AND TRANSPORTATION SAFETY, DOE O 460.2A, DEPARTMENTAL MATERIALS TRANSPORTATION AND PACKAGING MANAGEMENT

    Office of Energy Efficiency and Renewable Energy (EERE)

    "The familiar level of this module is divided into two sections. The objectives and requirements of DOE O 460.1C and DOE O 460.2A will be discussed in the first and second sections, respectively....

  10. Differential regulation of HIF-1α and HIF-2α in neuroblastoma: Estrogen-related receptor alpha (ERRα) regulates HIF2A transcription and correlates to poor outcome

    SciTech Connect (OSTI)

    Hamidian, Arash; Stedingk, Kristoffer von; Munksgaard Thorén, Matilda; Mohlin, Sofie; Påhlman, Sven

    2015-06-05

    Hypoxia-inducible factors (HIFs) are differentially regulated in tumor cells. While the current paradigm supports post-translational regulation of the HIF-α subunits, we recently showed that hypoxic HIF-2α is also transcriptionally regulated via insulin-like growth factor (IGF)-II in the childhood tumor neuroblastoma. Here, we demonstrate that transcriptional regulation of HIF-2α seems to be restricted to neural cell-derived tumors, while HIF-1α is canonically regulated at the post-translational level uniformly across different tumor forms. Enhanced expression of HIF2A mRNA at hypoxia is due to de novo transcription rather than increased mRNA stability, and chemical stabilization of the HIF-α proteins at oxygen-rich conditions unexpectedly leads to increased HIF2A transcription. The enhanced HIF2A levels do not seem to be dependent on active HIF-1. Using a transcriptome array approach, we identified members of the Peroxisome proliferator-activated receptor gamma coactivator (PGC)/Estrogen-related receptor (ERR) complex families as potential regulators of HIF2A. Knockdown or inhibition of one of the members, ERRα, leads to decreased expression of HIF2A, and high expression of the ERRα gene ESRRA correlates with poor overall and progression-free survival in a clinical neuroblastoma material consisting of 88 tumors. Thus, targeting of ERRα and pathways regulating transcriptional HIF-2α are promising therapeutic avenues in neuroblastoma. - Highlights: • Transcriptional control of HIF-2α is restricted to neural cell-derived tumors. • Enhanced transcription of HIF2A is not due to increased mRNA stability. • Chemical stabilization of the HIF-α subunits leads to increased HIF2A transcription. • ERRα regulates HIF2A mRNA expression in neuroblastoma. • High expression of ESRRA correlates to poor outcome in neuroblastoma.

  11. Biophysical Analysis of Anopheles gambiae Leucine-Rich Repeat Proteins APL1A1, APL1B and APL1C and Their Interaction with LRIM1

    SciTech Connect (OSTI)

    Williams, Marni; Summers, Brady J.; Baxter, Richard H. G.; Kobe, Bostjan

    2015-03-16

    Natural infection of Anopheles gambiae by malaria-causing Plasmodium parasites is significantly influenced by the APL1 genetic locus. The locus contains three closely related leucine-rich repeat (LRR) genes, APL1A, APL1B and APL1C. Multiple studies have reported the participation of APL1A—C in the immune response of A. gambiae to invasion by both rodent and human Plasmodium isolates. APL1C forms a heterodimer with the related LRR protein LRIM1 via a C-terminal coiled-coil domain that is also present in APL1A and APL1B. The LRIM1/APL1C heterodimer protects A. gambiae from infection by binding the complement-like protein TEP1 to form a stable and active immune complex. We report solution x-ray scatting data for the LRIM1/APL1C heterodimer, the oligomeric state of LRIM1/APL1 LRR domains in solution and the crystal structure of the APL1B LRR domain. The LRIM1/APL1C heterodimeric complex has a flexible and extended structure in solution. In contrast to the APL1A, APL1C and LRIM1 LRR domains, the APL1B LRR domain is a homodimer. The crystal structure of APL1B-LRR shows that the homodimer is formed by an N-terminal helix that complements for the absence of an N-terminal capping motif in APL1B, which is a unique distinction within the LRIM1/APL1 protein family. Full-length APL1A1 and APL1B form a stable complex with LRIM1. Our results support a model in which APL1A1, APL1B and APL1C can all form an extended, flexible heterodimer with LRIM1, providing a repertoire of functional innate immune complexes to protect A. gambiae from a diverse array of pathogens.

  12. Biophysical Analysis of Anopheles gambiae Leucine-Rich Repeat Proteins APL1A1, APL1B and APL1C and Their Interaction with LRIM1

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Williams, Marni; Summers, Brady J.; Baxter, Richard H. G.; Kobe, Bostjan

    2015-03-16

    Natural infection of Anopheles gambiae by malaria-causing Plasmodium parasites is significantly influenced by the APL1 genetic locus. The locus contains three closely related leucine-rich repeat (LRR) genes, APL1A, APL1B and APL1C. Multiple studies have reported the participation of APL1A—C in the immune response of A. gambiae to invasion by both rodent and human Plasmodium isolates. APL1C forms a heterodimer with the related LRR protein LRIM1 via a C-terminal coiled-coil domain that is also present in APL1A and APL1B. The LRIM1/APL1C heterodimer protects A. gambiae from infection by binding the complement-like protein TEP1 to form a stable and active immune complex.more » We report solution x-ray scatting data for the LRIM1/APL1C heterodimer, the oligomeric state of LRIM1/APL1 LRR domains in solution and the crystal structure of the APL1B LRR domain. The LRIM1/APL1C heterodimeric complex has a flexible and extended structure in solution. In contrast to the APL1A, APL1C and LRIM1 LRR domains, the APL1B LRR domain is a homodimer. The crystal structure of APL1B-LRR shows that the homodimer is formed by an N-terminal helix that complements for the absence of an N-terminal capping motif in APL1B, which is a unique distinction within the LRIM1/APL1 protein family. Full-length APL1A1 and APL1B form a stable complex with LRIM1. Our results support a model in which APL1A1, APL1B and APL1C can all form an extended, flexible heterodimer with LRIM1, providing a repertoire of functional innate immune complexes to protect A. gambiae from a diverse array of pathogens.« less

  13. Proteomic analysis of trichloroethylene-induced alterations in expression, distribution, and interactions of SET/TAF-Iα and two SET/TAF-Iα-binding proteins, eEF1A1 and eEF1A2, in hepatic L-02 cells

    SciTech Connect (OSTI)

    Hong, Wen-Xu; Yang, Liang; Chen, Moutong; Yang, Xifei; Ren, Xiaohu; Fang, Shisong; Ye, Jinbo; Huang, Haiyan; Peng, Chaoqiong; Zhou, Li; Huang, Xinfeng; Yang, Fan; Wu, Desheng; Zhuang, Zhixiong; Liu, Jianjun

    2012-09-01

    Emerging evidence indicates that trichloroethylene (TCE) exposure causes severe hepatotoxicity. However, the mechanisms of TCE hepatotoxicity remain unclear. Recently, we reported that TCE exposure up-regulated the expression of the oncoprotein SET/TAF-Iα and SET knockdown attenuated TCE-induced cytotoxicity in hepatic L-02 cells. To decipher the function of SET/TAF-Iα and its contributions to TCE-induced hepatotoxicity, we employed a proteomic analysis of SET/TAF-Iα with tandem affinity purification to identify SET/TAF-Iα-binding proteins. We identified 42 novel Gene Ontology co-annotated SET/TAF-Iα-binding proteins. The identifications of two of these proteins (eEF1A1, elongation factor 1-alpha 1; eEF1A2, elongation factor 1-alpha 2) were confirmed by Western blot analysis and co-immunoprecipitation (Co-IP). Furthermore, we analyzed the effects of TCE on the expression, distribution and interactions of eEF1A1, eEF1A2 and SET in L-02 cells. Western blot analysis reveals a significant up-regulation of eEF1A1, eEF1A2 and two isoforms of SET, and immunocytochemical analysis reveals that eEF1A1 and SET is redistributed by TCE. SET is redistributed from the nucleus to the cytoplasm, while eFE1A1 is translocated from the cytoplasm to the nucleus. Moreover, we find by Co-IP that TCE exposure significantly increases the interaction of SET with eEF1A2. Our data not only provide insights into the physiological functions of SET/TAF-Iα and complement the SET interaction networks, but also demonstrate that TCE exposure induces alterations in the expression, distribution and interactions of SET and its binding partners. These alterations may constitute the mechanisms of TCE cytotoxicity. -- Highlights: ► Identify 62 SET/TAF-Iα-associated proteins in human L-02 cells ► Trichloroethylene (TCE) alters the interaction of SET with eEF1A1 and eEF1A2. ► TCE induces the translocation and up-regulation of SET. ► TCE induces the translocation and up-regulation of eEF1A.

  14. c1a.xls

    Gasoline and Diesel Fuel Update (EIA)

    EIA-871A, C, and E of the 2003 Commercial Buildings Energy Consumption Survey. See "Guide to the Tables" or "Glossary" for further explanations of the terms used in this table....

  15. Page1A.PDF

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Probabilistic Mechanics and Structural and Geotechnical Reliability, Y.K. Lin ed., ASCE, July 1992. Fatigue Life Variability and Reliability Analysis of a Wind Turbine Blade* Paul...

  16. c1a.xls

    Gasoline and Diesel Fuel Update (EIA)

    ... 3,825 63,560 6,149 10,402 3,445 1,987 181 536 Buildings with Water Heating ... 3,659 62,827 6,158 10,202 3,379 2,035 218 525 Notes: Site...

  17. Addendum 1 - A5 CA

    National Nuclear Security Administration (NNSA)

    ... Bourcier, Andrew F. B., Carol J. Bruton, Steven F. Carl, Annie B. Kersting, Gayle A. Pawloski, Joseph A. Rard, Dana E. Shumaker, David K. Smith, and Andrew F. B. Tompson, March 23, ...

  18. Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: Essential roles of CYP2A5 and target-tissue metabolic activation

    SciTech Connect (OSTI)

    Xie Fang; Zhou Xin; Behr, Melissa; Fang Cheng; Horii, Yuichi; Gu Jun; Kannan, Kurunthachalam; Ding Xinxin

    2010-11-15

    The herbicide 2,6-dichlorobenzonitril (DCBN) is a potent and tissue-specific toxicant to the olfactory mucosa (OM). The toxicity of DCBN is mediated by cytochrome P450 (P450)-catalyzed bioactivation; however, it is not known whether target-tissue metabolic activation is essential for toxicity. CYP2A5, expressed abundantly in both liver and OM, was previously found to be one of the P450 enzymes active in DCBN bioactivation in vitro. The aims of this study were to determine the role of CYP2A5 in DCBN toxicity in vivo, by comparing the extents of DCBN toxicity between Cyp2a5-null and wild-type (WT) mice, and to determine whether hepatic microsomal P450 enzymes (including CYP2A5) are essential for the DCBN toxicity, by comparing the extents of DCBN toxicity between liver-Cpr-null (LCN) mice, which have little P450 activity in hepatocytes, and WT mice. We show that the loss of CYP2A5 expression did not alter systemic clearance of DCBN (at 25 mg/kg); but it did inhibit DCBN-induced non-protein thiol depletion and cytotoxicity in the OM. Thus, CYP2A5 plays an essential role in mediating DCBN toxicity in the OM. In contrast to the results seen in the Cyp2a5-null mice, the rates of systemic DCBN clearance were substantially reduced, while the extents of DCBN-induced nasal toxicity were increased, rather than decreased, in the LCN mice, compared to WT mice. Therefore, hepatic P450 enzymes, although essential for DCBN clearance, are not necessary for DCBN-induced OM toxicity. Our findings form the basis for a mechanism-based approach to assessing the potential risks of DCBN nasal toxicity in humans.

  19. CD94-NKG2A Recognition of Human Leukocyte Antigen (HLA)-E Bound to an HLA Class I Leader Sequence

    SciTech Connect (OSTI)

    Petrie,E.; Clements, C.; Lin, J.; Sullivan, L.; Johnson, D.; Huyton, T.; Heroux, A.; Hoare, H.; Beddoe, T.; et al

    2008-01-01

    The recognition of human leukocyte antigen (HLA)-E by the heterodimeric CD94-NKG2 natural killer (NK) receptor family is a central innate mechanism by which NK cells monitor the expression of other HLA molecules, yet the structural basis of this highly specific interaction is unclear. Here, we describe the crystal structure of CD94-NKG2A in complex with HLA-E bound to a peptide derived from the leader sequence of HLA-G. The CD94 subunit dominated the interaction with HLA-E, whereas the NKG2A subunit was more peripheral to the interface. Moreover, the invariant CD94 subunit dominated the peptide-mediated contacts, albeit with poor surface and chemical complementarity. This unusual binding mode was consistent with mutagenesis data at the CD94-NKG2A-HLA-E interface. There were few conformational changes in either CD94-NKG2A or HLA-E upon ligation, and such a 'lock and key' interaction is typical of innate receptor-ligand interactions. Nevertheless, the structure also provided insight into how this interaction can be modulated by subtle changes in the peptide ligand or by the pairing of CD94 with other members of the NKG2 family. Differences in the docking strategies used by the NKG2D and CD94-NKG2A receptors provided a basis for understanding the promiscuous nature of ligand recognition by NKG2D compared with the fidelity of the CD94-NKG2 receptors.

  20. Evaluation of Carrying Capacity : Measure 7.1A of the Northwest Power Planning Council`s 1994 Fish and Wildlife Program : Report 1 of 4, Final Report.

    SciTech Connect (OSTI)

    Neitzel, Duane A.; Johnson, Gary E.

    1996-05-01

    This report is one of four that the Pacific Northwest National Laboratory (PNNL) staff prepared to address Measure 7.1A in the Northwest Power Planning Council's (Council) Fish and Wildlife Program (Program) dated december 1994 (NPPC 1994). Measure 7.1A calls for the Bonneville Power Administration (BPA) to fund an evaluation of salmon survival, ecology, carrying capacity, and limiting factors in freshwater, estuarine, and marine habitats. Additionally, the Measure asks for development of a study plan based on critical uncertainties and research needs identified during the evaluation. This report deals with the evaluation of carrying capacity. It describes the analysis of different views of capacity as it relates to salmon survival and abundance. The report ends with conclusions and recommendations for studying carrying capacity.

  1. Premature chain termination is a unifying mechanism for COL1A1 null alleles in osteogenesis imperfecta type I cell strains

    SciTech Connect (OSTI)

    Willing, M.C.; Deschenes, S.P.; Roberts, E.J.

    1996-10-01

    Nonsense and frameshift mutations, which predict premature termination of translation, often cause a dramatic reduction in the amount of transcript from the mutant allele (nonsense-mediated mRNA decay). In some genes, these mutations also influence RNA splicing and induce skipping of the exon that contains the nonsense codon. To begin to dissect how premature termination alters the metabolism of RNA from the COL1A1 gene, we studied nonsense and frameshift mutations distributed over exons 11-49 of the gene. These mutations were originally identified in 10 unrelated families with osteogenesis imperfecta (OI) type I. We observed marked reduction in steady-state amounts of mRNA from the mutant allele in both total cellular and nuclear RNA extracts of cells from affected individuals, suggesting that nonsense-mediated decay of COL1A1 RNA is a nuclear phenomenon. Position of the mutation within the gene did not influence this observation. None of the mutations induced skipping of either the exon containing the mutation or, for the frameshifts, the downstream exons with the new termination sites. Our data suggest that nonsense and frameshift mutations throughout most of the COL1A1 gene result in a null allele, which is associated with the predictable mild clinical phenotype, OI type I. 42 refs., 6 figs., 1 tab.

  2. Mutation in a gene for type I procollagen (COL1A2) in a woman with postmenopausal osteoporosis: Evidence for phenotypic and genotypic overlap with mild osteogenesis imperfecta

    SciTech Connect (OSTI)

    Spotila, L.D.; Constantinou, C.D.; Sereda, L.; Ganguly, A.; Prockop, D.J. ); Riggs, B.L. )

    1991-06-15

    Mutations in the two genes for type I collagen (COL1A1 or COL1A2) cause osteogenesis imperfecta (OI), a heritable disease characterized by moderate to extreme brittleness of bone early in life. Here, the authors show that a 52-year-old post menopausal woman with severe osteopenia and a compression fracture of a thoracic vertebra had a mutation in the gene for the {alpha}2(I) chain of type I collagen (COL1A2) similar to mutations that cause OI. cDNA was prepared from the woman's skin fibroblast RNA and assayed for the presence of a mutation by treating DNA heteroduplexes with carbodiimide. The results indicated a sequence variation in the region encoding amino acid residues 660-667 of the {alpha}2(I) chain. Further analysis demonstrated a single-base mutation that caused a serine-for-glycine substitution at position 661 of the {alpha}2(I) triple-helical domain. The substitution produced posttranslational overmodification of the collagen triple helix, as is seen with most glycine substitutions that cause OI. The patient had a history of five previous fractures, slightly blue sclerae, and slight hearing loss. Therefore, the results suggest that there may be phenotypic and genotypic overlap between mild osteogenesis imperfecta and postmenopausal osteoporosis, and that a subset of women with postmenopausal osteoporosis may have mutations in the genes for type I procollagen.

  3. The effects of clobazam treatment in rats on the expression of genes and proteins encoding glucronosyltransferase 1A/2B (UGT1A/2B) and multidrug resistance‐associated protein-2 (MRP2), and development of thyroid follicular cell hypertrophy

    SciTech Connect (OSTI)

    Miyawaki, Izuru Tamura, Akitoshi; Matsumoto, Izumi; Inada, Hiroshi; Kunimatsu, Takeshi; Kimura, Juki; Funabashi, Hitoshi

    2012-12-15

    Clobazam (CLB) is known to increase hepatobiliary thyroxine (T4) clearance in Sprague–Dawley (SD) rats, which results in hypothyroidism followed by thyroid follicular cell hypertrophy. However, the mechanism of the acceleration of T4-clearance has not been fully investigated. In the present study, we tried to clarify the roles of hepatic UDP-glucronosyltransferase (UGT) isoenzymes (UGT1A and UGT2B) and efflux transporter (multidrug resistance–associated protein-2; MRP2) in the CLB-induced acceleration of T4-clearance using two mutant rat strains, UGT1A-deficient mutant (Gunn) and MRP2-deficient mutant (EHBR) rats, especially focusing on thyroid morphology, levels of circulating hormones (T4 and triiodothyronine (T3)) and thyroid-stimulating hormone (TSH), and mRNA or protein expressions of UGTs (Ugt1a1, Ugt1a6, and Ugt2b1/2) and MRP2 (Mrp). CLB induced thyroid morphological changes with increases in TSH in SD and Gunn rats, but not in EHBR rats. T4 was slightly decreased in SD and Gunn rats, and T3 was decreased in Gunn rats, whereas these hormones were maintained in EHBR rats. Hepatic Ugt1a1, Ugt1a6, Ugt2b1/2, and Mrp2 mRNAs were upregulated in SD rats. In Gunn rats, UGT1A mRNAs (Ugt1a1/6) and protein levels were quite low, but UGT2B mRNAs (Ugt2b1/2) and protein were prominently upregulated. In SD and Gunn rats, MRP2 mRNA and protein were upregulated to the same degree. These results suggest that MRP2 is an important contributor in development of the thyroid cellular hypertrophy in CLB-treated rats, and that UGT1A and UGT2B work in concert with MRP2 in the presence of MRP2 function to enable the effective elimination of thyroid hormones. -- Highlights: ► Role of UGT and MRP2 in thyroid pathology was investigated in clobazam-treated rats. ► Clobazam induced thyroid cellular hypertrophy in SD and Gunn rats, but not EHBR rats. ► Hepatic Mrp2 gene and protein were upregulated in SD and Gunn rats, but not EHBR rats. ► Neither serum thyroid hormones (T3/T4

  4. Data:Eac1dd3a-0268-4e5c-b1d1-ed9feeb2a12a | Open Energy Information

    Open Energy Info (EERE)

    Eac1dd3a-0268-4e5c-b1d1-ed9feeb2a12a No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading......

  5. Data:F3d511d9-6321-49ce-b5b2-a0d21fd28d52 | Open Energy Information

    Open Energy Info (EERE)

    d9-6321-49ce-b5b2-a0d21fd28d52 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1....

  6. Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines

    SciTech Connect (OSTI)

    Vorrink, Sabine U.; Severson, Paul L.; Kulak, Mikhail V.; Futscher, Bernard W.; Domann, Frederick E.

    2014-02-01

    The aryl hydrocarbon receptor (AhR) is an important mediator of toxic responses after exposure to xenobiotics including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and dioxin-like polychlorinated biphenyls (PCBs). Activation of AhR responsive genes requires AhR dimerization with the aryl hydrocarbon receptor nuclear translocator (ARNT), a heterodimeric partner also shared by the hypoxia-inducible factor-1α (HIF-1α) protein. TCDD-stimulated AhR transcriptional activity can be influenced by hypoxia; however, it less well known whether hypoxia interferes with AhR transcriptional transactivation in the context of PCB-mediated AhR activation in human cells. Elucidation of this interaction is important in liver hepatocytes which extensively metabolize ingested PCBs and experience varying degrees of oxygen tension during normal physiologic function. This study was designed to assess the effect of hypoxia on AhR transcriptional responses after exposure to 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126). Exposure to 1% O{sub 2} prior to PCB 126 treatment significantly inhibited CYP1A1 mRNA and protein expression in human HepG2 and HaCaT cells. CYP1A1 transcriptional activation was significantly decreased upon PCB 126 stimulation under conditions of hypoxia. Additionally, hypoxia pre-treatment reduced PCB 126 induced AhR binding to CYP1 target gene promoters. Importantly, ARNT overexpression rescued cells from the inhibitory effect of hypoxia on XRE-luciferase reporter activity. Therefore, the mechanism of interference of the signaling crosstalk between the AhR and hypoxia pathways appears to be at least in part dependent on ARNT availability. Our results show that AhR activation and CYP1A1 expression induced by PCB 126 were significantly inhibited by hypoxia and hypoxia might therefore play an important role in PCB metabolism and toxicity. - Highlights: • Significant crosstalk exists between AhR and HIF-1α signaling. • Hypoxia perturbs PCB 126 induced AhR function and

  7. Collaborating CPU and GPU for large-scale high-order CFD simulations with complex grids on the TianHe-1A supercomputer

    SciTech Connect (OSTI)

    Xu, Chuanfu; Deng, Xiaogang; Zhang, Lilun; Fang, Jianbin; Wang, Guangxue; Jiang, Yi; Cao, Wei; Che, Yonggang; Wang, Yongxian; Wang, Zhenghua; Liu, Wei; Cheng, Xinghua

    2014-12-01

    Programming and optimizing complex, real-world CFD codes on current many-core accelerated HPC systems is very challenging, especially when collaborating CPUs and accelerators to fully tap the potential of heterogeneous systems. In this paper, with a tri-level hybrid and heterogeneous programming model using MPI + OpenMP + CUDA, we port and optimize our high-order multi-block structured CFD software HOSTA on the GPU-accelerated TianHe-1A supercomputer. HOSTA adopts two self-developed high-order compact definite difference schemes WCNS and HDCS that can simulate flows with complex geometries. We present a dual-level parallelization scheme for efficient multi-block computation on GPUs and perform particular kernel optimizations for high-order CFD schemes. The GPU-only approach achieves a speedup of about 1.3 when comparing one Tesla M2050 GPU with two Xeon X5670 CPUs. To achieve a greater speedup, we collaborate CPU and GPU for HOSTA instead of using a naive GPU-only approach. We present a novel scheme to balance the loads between the store-poor GPU and the store-rich CPU. Taking CPU and GPU load balance into account, we improve the maximum simulation problem size per TianHe-1A node for HOSTA by 2.3×, meanwhile the collaborative approach can improve the performance by around 45% compared to the GPU-only approach. Further, to scale HOSTA on TianHe-1A, we propose a gather/scatter optimization to minimize PCI-e data transfer times for ghost and singularity data of 3D grid blocks, and overlap the collaborative computation and communication as far as possible using some advanced CUDA and MPI features. Scalability tests show that HOSTA can achieve a parallel efficiency of above 60% on 1024 TianHe-1A nodes. With our method, we have successfully simulated an EET high-lift airfoil configuration containing 800M cells and China's large civil airplane configuration containing 150M cells. To our best knowledge, those are the largest-scale CPU–GPU collaborative simulations that

  8. Four crystal structures of human LLT1, a ligand of human NKR-P1, in varied glycosylation and oligomerization states

    SciTech Connect (OSTI)

    Skálová, Tereza; Bláha, Jan; Harlos, Karl; Dušková, Jarmila; Koval’, Tomáš; Stránský, Jan; Hašek, Jindřich; Vaněk, Ondřej; Dohnálek, Jan

    2015-03-01

    Four crystal structures of human LLT1, a ligand of human NKR-P1, are reported. Human LLT1 is a C-type lectin-like ligand of NKR-P1 (CD161, gene KLRB1), a C-type lectin-like receptor of natural killer cells. Using X-ray diffraction, the first experimental structures of human LLT1 were determined. Four structures of LLT1 under various conditions were determined: monomeric, dimeric deglycosylated after the first N-acetylglucosamine unit in two forms and hexameric with homogeneous GlcNAc{sub 2}Man{sub 5} glycosylation. The dimeric form follows the classical dimerization mode of human CD69. The monomeric form keeps the same fold with the exception of the position of an outer part of the long loop region. The hexamer of glycosylated LLT1 consists of three classical dimers. The hexameric packing may indicate a possible mode of interaction of C-type lectin-like proteins in the glycosylated form.

  9. An N-terminal glycine to cysteine mutation in the collagen COL1A1 gene produces moderately severe osteogenesis imperfecta

    SciTech Connect (OSTI)

    Wilcox, W.; Scott, L.; Cohn, D.

    1994-09-01

    Osteogenesis imperfecta (OI) is usually due to mutations in the type I procollagen genes COL1A1 and COL1A2. Point mutations close to the N-terminus are generally milder than those near the C-terminus of the molecule (the gradient hypothesis of collagen mutations). We describe a patient with moderately severe OI due to a mutation in the N-terminal portion of the triple helical domain of the {alpha}1(I) chain. Electrophoretic analysis of collagen isolated from fibroblast cultures suggested the abnormal presence of a cysteine in the N-terminal portion of the {alpha}1(I) chain. Five overlapping DNA fragments amplified from fibroblast RNA were screened for mutations using single strand conformational polymorphism (SSCP) and heteroduplex analyses. Direct DNA sequence analysis of the single positive fragment demonstrated a G to T transversion, corresponding to a glycine to cysteine substitution at position 226 of the triple helical domain of the {alpha}1(I) chain. The mutation was confirmed by restriction enzyme analysis of amplified genomic DNA. The mutation was not present in fibroblasts from either phenotypically normal parent. Combining this mutation with other reported mutations, glycine to cysteine substitutions at positions 205, 211, 223, and 226 produce a moderately severe phenotype whereas flanking mutations at positions 175 and 382 produce a mild phenotype. This data supports a regional rather than a gradient model of the relationship between the nature and location of type I collagen mutations and OI phenotype.

  10. The potential effect of metallothionein 2A - 5 A/G single nucleotide polymorphism on blood cadmium, lead, zinc and copper levels

    SciTech Connect (OSTI)

    Kayaalti, Zeliha Aliyev, Vugar; Soeylemezoglu, Tuelin

    2011-10-01

    Metallothioneins (MTs) are low molecular weight, cysteine-rich, metal-binding proteins. Because of their rich thiol groups, MTs bind to the biologically essential metals and perform these metals' homeostatic regulations; absorb the heavy metals and assist with their transportation and extraction. The aim of this study was to investigate the association between the metallothionein 2A (MT2A) core promoter region - 5 A/G single nucleotide polymorphism (SNP) and Cd, Pb, Zn and Cu levels in the blood samples. MT2A polymorphism was determined by the standard polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique using the 616 blood samples and the genotype frequencies were found as 86.6% homozygote typical (AA), 12.8% heterozygote (AG) and 0.6% homozygote atypical (GG). Metal levels were analyzed by dual atomic absorption spectrophotometer system and the average levels of Cd, Pb, Zn and Cu in the blood samples were 1.69 {+-} 1.57 ppb, 30.62 {+-} 14.13 ppb, 0.98 {+-} 0.49 ppm and 1.04 {+-} 0.45 ppm, respectively. As a result; highly statistically significant associations were detected between the - 5 A/G core promoter region SNP in the MT2A gene and Cd, Pb and Zn levels (p = 0.004, p = 0.012 and p = 0.002, respectively), but no association was found with Cu level (p = 0.595). Individuals with the GG genotype had statistically lower Zn level and higher Cd and Pb levels in the blood samples than individuals with AA and AG genotypes. This study suggests that having the GG genotype individuals may be more sensitive for the metal toxicity and they should be more careful about protecting their health against the toxic effects of the heavy metals. - Highlights: > MT2A -5A/G SNP has strong effect on the Cd, Pb and Zn levels in the blood. > MT2A GG individuals should be more careful for their health against metal toxicity. > This SNP might be considered as a biomarker for risk of disease related to metals.

  11. c2a.xls

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    Buildings ... 4,859 71,658 107,897 82,783 16,010 1,826 7,279 Building Floorspace (Square Feet) 1,001 to 5,000 ......

  12. Neutron scattering studies of the H2a-H2b and (H3-H4)/sub 2/ histone complexes

    SciTech Connect (OSTI)

    Carlson, R.D.

    1982-01-01

    Neutron scattering experiments have shown that both the (H3-H4)/sub 2/ and H2a-H2b histone complexes are quite asymmetric in solution. The (H3-H4)/sub 2/ tetramer is an oblate or flattened structure, with a radius of gyration almost as large as that of the core octamer. If the tetramer is primarily globular, it must have an axial ratio of about 1:5. It is more likely, however, that this asymmetry results in part from N-terminal arms that extend outward approximately within the major plane of the particle. If this is the case, less asymmetric models for the globular part of the tetramer, including a dislocated disk, can be made consistent with the scattering data. The H2a-H2b dimer, on the other hand, is an elongated structure. 48 references, 12 figures, 1 table.

  13. Draft Genome Sequence of thermoalkaliphilic Caldalkalibacillus thermarum strain TA2.A1 Reveals Molecular Adaptations to Extreme pH and Temperature

    SciTech Connect (OSTI)

    Kalamorz, Falk; Keis, Stefanie; Stanton, Jo-Ann; Brown, Steven D; Klingeman, Dawn Marie; Land, Miriam L; Han, Cliff; Martin, S L.; Morgan, Hugh; Cook, Greg

    2011-01-01

    The genes and molecular machines that allow for a thermoalkaliphilic lifestyle have not been defined. To address this goal, we report on the improved high-quality draft genome sequence of Caldalkalibacillus thermarum strain TA2.A1, an obligately aerobic bacterium that grows optimally at pH 9.5 and 65 to 70 C on a wide variety of carbon and energy sources.

  14. A second mutation in the type II procollagen gene (COL2A1) causing Stickler syndrome (arthro-ophthalmopathy) is also a premature termination codon

    SciTech Connect (OSTI)

    Ahmad, N.N.; Knowlton, R.G.; DiMascio, J.; Prockop, D.J. ); McDonald-McGinn, D.M.; Zackai, E.H.; LaRossa, D. )

    1993-01-01

    Genetic linkage analyses suggest that mutations in type II collagen may be responsible for Stickler syndrome, or arthro-ophthalmopathy (AO), in many families. In the present study oligonucleotide primers were developed to amplify and directly sequence eight of the first nine exons of the gene for type II procollagen (COL2A1). Analysis of the eight exons in 10 unrelated probands with AO revealed that one had a single-base mutation in one allele that changed the codon of -CGA- for arginine at amino acid position [alpha]1-9 in exon 7 to a premature termination signal for translation. The second mutation found to cause AO was, therefore, similar to the first in that both created premature termination signals in the COL2A1 gene. Since mutations producing premature termination signals have not previously been detected in genes for fibrillar collagens, the results raise the possibility that such mutations in the COL2A1 gene are a common cause of AO. 33 refs., 4 figs., 2 tabs.

  15. Proceedings of the Third NRC/ASME Symposium on Valve and Pump Testing. Session 1A--Session 2C: Volume 1

    SciTech Connect (OSTI)

    Not Available

    1994-07-01

    The 1994 Symposium on Valve and Pump Testing, jointly sponsored by the Board of Nuclear Codes and Standards of the American Society of Mechanical Engineers and by the Nuclear Regulatory Commission, provides a forum for the discussion of current programs and methods for inservice testing and motor-operated valve testing at nuclear power plants. The symposium also provides an opportunity to discuss the need to improve that testing in order to help ensure the reliable performance of pumps and valves. The participation of industry representatives, regulators, and consultants results in the discussion of a broad spectrum of ideas and perspectives regarding the improvement of inservice testing of pumps and valves at nuclear power plants. This document, Volume 1, covers sessions 1A through session 2C. The individual papers have been cataloged separately.

  16. Single Vocal Cord Irradiation: Image Guided Intensity Modulated Hypofractionated Radiation Therapy for T1a Glottic Cancer: Early Clinical Results

    SciTech Connect (OSTI)

    Al-Mamgani, Abrahim; Kwa, Stefan L.S.; Tans, Lisa; Moring, Michael; Fransen, Dennie; Mehilal, Robert; Verduijn, Gerda M.; Baatenburg de Jong, Rob J.; Heijmen, Ben J.M.; Levendag, Peter C.

    2015-10-01

    Purpose: To report, from a retrospective analysis of prospectively collected data, on the feasibility, outcome, toxicity, and voice-handicap index (VHI) of patients with T1a glottic cancer treated by a novel intensity modulated radiation therapy technique developed at our institution to treat only the involved vocal cord: single vocal cord irradiation (SVCI). Methods and Materials: Thirty patients with T1a glottic cancer were treated by means of SVCI. Dose prescription was set to 16 × 3.63 Gy (total dose 58.08 Gy). The clinical target volume was the entire vocal cord. Setup verification was done by means of an online correction protocol using cone beam computed tomography. Data for voice quality assessment were collected prospectively at baseline, end of treatment, and 4, 6, and 12 weeks and 6, 12, and 18 months after treatment using VHI questionnaires. Results: After a median follow-up of 30 months (range, 7-50 months), the 2-year local control and overall survival rates were 100% and 90% because no single local recurrence was reported and 3 patients died because of comorbidity. All patients have completed the intended treatment schedule; no treatment interruptions and no grade 3 acute toxicity were reported. Grade 2 acute dermatitis or dysphagia was reported in only 5 patients (17%). No serious late toxicity was reported; only 1 patient developed temporary grade 2 laryngeal edema, and responded to a short-course of corticosteroid. The VHI improved significantly, from 33.5 at baseline to 9.5 and 10 at 6 weeks and 18 months, respectively (P<.001). The control group, treated to the whole larynx, had comparable local control rates (92.2% vs 100%, P=.24) but more acute toxicity (66% vs 17%, P<.0001) and higher VHI scores (23.8 and 16.7 at 6 weeks and 18 months, respectively, P<.0001). Conclusion: Single vocal cord irradiation is feasible and resulted in maximal local control rate at 2 years. The deterioration in VHI scores was slight and temporary and

  17. Preparation of the Crystal Complex of Phosphopantetheine Adenylyltransferase from Mycobacterium tuberculosis with Coenzyme A and Investigation of Its Three-Dimensional Structure at 2.1-A Resolution

    SciTech Connect (OSTI)

    Timofeev, V. I.; Smirnova, E. A.; Chupova, L. A.; Esipov, R. S.; Kuranova, I. P.

    2010-11-15

    Recombinant phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis (PPAT Mt), which was produced by a high-producing strain and purified to 99%, was used for the crystal growth of the complex of the enzyme with coenzyme A (CoA). Crystals suitable for X-ray diffraction study were obtained by cocrystallization. The crystals belong to sp. gr. R32 and have the unit-cell parameters a = b = 98.840 A, c = 112.880 A, {alpha} = {beta} = 90.00{sup o}, and {gamma} = 120.00{sup o}. The three-dimensional structure of the complex was determined based on X-ray diffraction data collected from the crystals to 2.1 A resolution and refined to Rf = 22.7% and Rfree = 25.93%. Active-site bound coenzyme A was found, and its nearest environment was described. The conformational changes of the enzyme due to ligand binding were revealed. The binding of CoA by tuberculosis phosphopantetheine adenylyltransferase was characterized by comparing the structures of the title complex to a similar complex of PPAT from E. coli (PPAT Ec).

  18. The Global Carbon Bank | Open Energy Information

    Open Energy Info (EERE)

    Global Carbon Bank Jump to: navigation, search Name: The Global Carbon Bank Place: Houston, Texas Zip: 77025 Sector: Carbon, Services Product: Houston-based provider of advisory...

  19. Conservation Capital LLC | Open Energy Information

    Open Energy Info (EERE)

    Conservation Capital LLC Jump to: navigation, search Name: Conservation Capital LLC Place: Houston, Texas Zip: 77018 Product: Houston-based land investment and consulting company...

  20. Standard Renewable Energy SRE | Open Energy Information

    Open Energy Info (EERE)

    Renewable Energy SRE Jump to: navigation, search Name: Standard Renewable Energy (SRE) Place: Houston, Texas Zip: 77007 Sector: Renewable Energy, Services Product: Houston-based...

  1. "DOE IDIQ ESPC Awarded Projects Summary

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... Fe Las Cruces Houston Corpus Christi Tyler Batesville Pine Bluff New Orleans ... Fe Las Cruces Houston Corpus Christi Tyler Batesville Pine Bluff New Orleans ...

  2. Design of Integrated Laboratory and Heavy-Duty Emissions Testing...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Houston and City of Houston: Collaboration to Determine Best Solutions for Diesel Emission Reductions Combining Biodiesel and EGR for Low-Temperature NOx and PM Reductions

  3. Free Green Energy LLC | Open Energy Information

    Open Energy Info (EERE)

    LLC Jump to: navigation, search Name: Free Green Energy LLC Place: Houston, Texas Zip: 77060 Sector: Geothermal energy Product: Houston-based company formed to develop geothermal...

  4. Endicott Biofuels II LLC | Open Energy Information

    Open Energy Info (EERE)

    Endicott Biofuels II LLC Jump to: navigation, search Name: Endicott Biofuels II, LLC Place: Houston, Texas Zip: 77060-3235 Sector: Biofuels Product: Houston-based biofuels producer...

  5. Green Star Energy LLC | Open Energy Information

    Open Energy Info (EERE)

    LLC Jump to: navigation, search Name: Green Star Energy LLC Place: Houston, Texas Zip: 77002 Product: Houston-based producer of sugar cane processed ethanol, with additional...

  6. Six novel transition-metal phosphite compounds, with structure related to yavapaiite: Crystal structures and magnetic and thermal properties of A{sup I}[M{sup III}(HPO{sub 3}){sub 2}] (A=K, NH{sub 4}, Rb and M=V, Fe)

    SciTech Connect (OSTI)

    Hamchaoui, Farida; Alonzo, Veronique; Universite Europeenne de Bretagne ; Venegas-Yazigi, Diego; Rebbah, Houria; Le Fur, Eric

    2013-02-15

    Six new transition metal(III) phosphites A{sup I}[V{sup III}(HPO{sub 3}){sub 2}], where A=K (1), NH{sub 4} (2) and Rb (3) and A{sup I}[Fe{sup III}(HPO{sub 3}){sub 2}] where A=K (4), NH{sub 4} (5) and Rb (6) have been synthesized under hydrothermal conditions and the solid-state structures were solved from single-crystal X-ray diffraction data. These compounds crystallize in the hexagonal system, space group P6{sub 3}mc (no. 186), with a=5.3294(2) A and c=12.3130(5) A for 1, a=5.3330(2) A and c=12.8760(4) A for 2, a=5.3459(2) A and c=12.6850(8) A for 3, a=5.3256(1) A and c=12.2362(3) A for 4, a=5.3229(2) A and c=12.8562(4) A for 5, a=5.3393(2) A and c=12.6913(5) A for 6, with Z=2 in the six phases. The crystal structures of these compounds are isotypic and exhibit a layered structure stacked along the c-axis with the A{sup +} cations located in the interlayer space. The [M{sup III}(HPO{sub 3}){sub 2}]{sup -} sheets are formed by MO{sub 6} octahedra interconnected by HPO{sub 3} tetrahedral phosphite oxoanions through sharing vertices. Thermal analysis shows a large range of stability for compounds containing potassium and rubidium cations with decomposition starting around 550 K for stable compounds and above 840 K for the most stable compounds leading in general to pyrophosphate compounds. Triangular nets of metallic centers are observed within the layers in which antiferromagnetic interactions are evidenced by magnetic susceptibility measurements suggesting magnetic frustration. - Graphical abstract: Six new transition metal(III) phosphites A{sup I}[M{sup III}(HPO{sub 3}){sub 2}], where A=K, NH{sub 4}, Rb and M=V, Fe, have been synthesized. The crystal structures of these compounds are isotypic and exhibit a lamellar structure related to Yavapaiite. The M(HPO{sub 3}){sub 2} layers separated by cationic species present the metallic centers in a triangular arrangement. Bulk antiferromagnetic behavior is observed for all the studied compounds. Highlights: Black

  7. Bulk and mechanical properties of the Paintbrush tuff recovered from boreholes UE25 NRG-2, 2A, 2B, and 3: Data report

    SciTech Connect (OSTI)

    Boyd, P.J.; Martin, R.J.; Noel, J.S. [New England Research, Inc., White River Junction, VT (United States); Price, R.H. [Sandia National Labs., Albuquerque, NM (United States)

    1996-09-01

    An integral part of the licensing procedure for the potential nuclear waste repository at Yucca Mountain, Nevada, involves characterization of the in situ rheology for the design and construction of the facility and the emplacement of canisters containing radioactive waste. The data used to model the thermal and mechanical behavior of the repository and surrounding lithologies include dry and saturated bulk densities, average grain density, porosity, compressional and shear wave velocities, elastic moduli, and compressional and tensional fracture strengths. In this study, a suite of experiments was performed on cores recovered from boreholes UE25 NRG-2, 2A, 2B, and 3 drilled in support of the Exploratory Studies Facility (ESF) at Yucca Mountain. The holes penetrated the Timber Mountain tuff and two thermal/mechanical units of the Paintbrush tuff. The thermal/mechanical stratigraphy was defined by Ortiz to group rock horizons of similar properties for the purpose of simplifying modeling efforts. The relationship between the geologic stratigraphy and the thermal/mechanical stratigraphy for each borehole is presented. The tuff samples in this study have a wide range of welding characteristics (usually reflected in sample porosity), and a smaller range of mineralogy and petrology characteristics. Generally, the samples are silicic, ash-fall tuffs that exhibit large variability in their elastic and strength properties.

  8. [beta]-BaV[sub 2](P[sub 2]O[sub 7])[sub 2]: A new polymorph of barium vanadium (III) pyrophosphate characterized by intersecting tunnels

    SciTech Connect (OSTI)

    Hwu, Shiou-Jyh; Carroll, R.I.; Serra, D.L. )

    1994-06-01

    Investigation into the synthesis of reduced vanadium phosphate has led to the formation of a new form of the barium vanadium (III) pyrophosphate compound [beta]-BaV[sub 2](P[sub 2]O[sub 7])[sub 2]. It is a polymorph of the previously known BaV[sub 2](P[sub 2]O[sub 7])[sub 2], which is now labeled as the [alpha]-phase. The title compound crystallizes in the P-1 (No. 2) space group with a = 6.269 (1) [angstrom], b = 7.864 (3) [angstrom], c = 6.1592 (9) [angstrom], [alpha] = 101.34 (2)[degree], [beta] = 105.84 (1)[degree], and [gamma] = 96.51 (2)[degree]. The structure consists of corner-shared VO[sub 6] octahedra and PO[sub 4] tetrahedra that are connected in V-O-P-O-V and V-O-P-O-P-O-V bonding arrangements. This interesting three-dimensional framework is characterized by seven types of intersecting tunnels, three of which are occupied by the barium cation, while the others are empty. It is important to know that one of the empty tunnels has a relatively large window with a minimum diagonal distance of 4.4 [angstrom], which facilitates a possible framework for a lithium ion insertion reaction. The barium atom has a 10-coordination sphere, BaO[sub 10], in which the oxygen atoms can be viewed as forming two intersecting pseudohexagonal planes. [beta]-BaV[sub 2](P[sub 2]O[sub 7])[sub 2] appears to form at a relatively higher temperature than its polymorph, [alpha]-BaV[sub 2](P[sub 2]O[sub 7])[sub 2]. A detailed structural analysis and structural comparison with the [alpha]-phase, as well as a brief comparison with SrV[sub 2](P[sub 2]O[sub 7])[sub 2], are presented.

  9. Preferential Eu Site Occupation and Its Consequences in the Ternary Luminescent HalidesAB2I5:Eu2+(A=Li–Cs;B=Sr, Ba)

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Fang, C.  M.; Biswas, Koushik

    2015-07-22

    Several rare-earth-doped, heavy-metal halides have recently been identified as potential next-generation luminescent materials with high efficiency at low cost. AB2I5:Eu2+ (A=Li–Cs; B=Sr, Ba) is one such family of halides. Its members, such as CsBa2I5:Eu2+ and KSr2I5:Eu2+, are currently being investigated as high-performance scintillators with improved sensitivity, light yield, and energy resolution less than 3% at 662 keV. Within the AB2I5 family, our first-principles-based calculations reveal two remarkably different trends in Eu site occupation. The substitutional Eu ions occupy both eightfold-coordinated B1(VIII) and the sevenfold-coordinated B2(VII) sites in the Sr-containing compounds. However, in the Ba-containing crystals, Eu ions strongly prefer themore »B2(VII)sites. This random versus preferential distribution of Eu affects their electronic properties. The calculations also suggest that in the Ba-containing compounds one can expect the formation of Eu-rich domains. These results provide atomistic insight into recent experimental observations about the concentration and temperature effects in Eu-doped CsBa2I5. We discuss the implications of our results with respect to luminescent properties and applications. We also hypothesize Sr, Ba-mixed quaternary iodides ABaVIIISrVIII5:Eu as scintillators having enhanced homogeneity and electronic properties.« less

  10. Preferential Eu Site Occupation and Its Consequences in the Ternary Luminescent HalidesAB2I5:Eu2+(A=Li–Cs;B=Sr, Ba)

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Fang, C.  M.; Biswas, Koushik

    2015-07-22

    Several rare-earth-doped, heavy-metal halides have recently been identified as potential next-generation luminescent materials with high efficiency at low cost. AB2I5:Eu2+ (A=Li–Cs; B=Sr, Ba) is one such family of halides. Its members, such as CsBa2I5:Eu2+ and KSr2I5:Eu2+, are currently being investigated as high-performance scintillators with improved sensitivity, light yield, and energy resolution less than 3% at 662 keV. Within the AB2I5 family, our first-principles-based calculations reveal two remarkably different trends in Eu site occupation. The substitutional Eu ions occupy both eightfold-coordinated B1(VIII) and the sevenfold-coordinated B2(VII) sites in the Sr-containing compounds. However, in the Ba-containing crystals, Eu ions strongly prefer themore » B2(VII)sites. This random versus preferential distribution of Eu affects their electronic properties. The calculations also suggest that in the Ba-containing compounds one can expect the formation of Eu-rich domains. These results provide atomistic insight into recent experimental observations about the concentration and temperature effects in Eu-doped CsBa2I5. We discuss the implications of our results with respect to luminescent properties and applications. We also hypothesize Sr, Ba-mixed quaternary iodides ABaVIIISrVIII5:Eu as scintillators having enhanced homogeneity and electronic properties.« less

  11. Buildings Energy Data Book: 3.6 Office Building Markets and Companies

    Buildings Energy Data Book [EERE]

    0 Energy Benchmarks for Existing Medium Office Buildings, by Selected City and End-Use (thousand Btu per square foot) IECC Post Pre Post Pre Post Pre Post Pre Miami 1A 1.0 0.0 22.0 19.2 0.4 0.4 1.9 13.0 Houston 2A 4.6 1.8 15.5 14.7 0.5 0.5 1.5 12.8 Phoenix 2B 4.0 0.7 17.5 19.4 0.4 0.4 1.9 15.0 Atlanta 3A 7.8 4.3 10.1 10.4 0.6 0.5 1.4 13.9 Los Angeles 3B 4.1 0.3 8.0 3.5 0.5 0.5 1.4 10.9 Las Vegas 3B 5.6 1.4 13.2 14.6 0.5 0.5 1.8 14.5 San Francisco 3C 5.8 1.7 2.9 1.2 0.6 0.6 1.1 8.9 Baltimore 4A

  12. Buildings Energy Data Book: 3.6 Office Building Markets and Companies

    Buildings Energy Data Book [EERE]

    8 Energy Benchmarks for Existing Large Office Buildings, by Selected City and End-Use (thousand Btu per square foot) IECC Post Pre Post Pre Post Pre Post Pre Miami 1A 0.3 0.8 21.9 24.5 0.3 0.2 3.1 3.5 Houston 2A 4.2 4.4 17.7 20.9 0.3 0.3 2.8 3.3 Phoenix 2B 3.0 3.3 16.2 18.3 0.3 0.3 3.2 3.7 Atlanta 3A 6.9 8.5 14.1 17.5 0.4 0.4 2.6 3.2 Los Angeles 3B 2.8 2.9 11.9 13.0 0.4 0.4 2.5 2.7 Las Vegas 3B 4.6 4.7 10.8 13.0 0.3 0.3 2.7 3.3 San Francisco 3C 5.0 6.4 5.6 6.6 0.4 0.4 1.8 2.1 Baltimore 4A 9.8

  13. Buildings Energy Data Book: 3.7 Retail Markets and Companies

    Buildings Energy Data Book [EERE]

    5 Energy Benchmarks for Existing Retail Buildings, by Selected City and End-Use (thousand Btu per square foot) IECC Post Pre Post Pre Post Pre Miami 1A 0.5 0.7 23.0 25.2 14.3 16.1 Houston 2A 11.6 12.4 16.2 18.9 14.6 16.9 Phoenix 2B 8.3 10.2 17.2 21.3 14.2 17.5 Atlanta 3A 24.9 26.2 9.2 11.2 15.1 17.4 Los Angeles 3B 6.9 7.7 3.3 3.9 13.4 14.1 Las Vegas 3B 15.4 17.9 11.6 14.8 12.7 16.9 San Francisco 3C 22.4 22.5 0.7 1.0 10.6 12.1 Baltimore 4A 43.0 46.9 6.2 7.9 13.3 16.2 Albuquerque 4B 30.2 33.8 5.3

  14. Buildings Energy Data Book: 3.7 Retail Markets and Companies

    Buildings Energy Data Book [EERE]

    7 Energy Benchmarks for Existing Supermarkets, by Selected City and End-Use (thousand Btu per square foot) IECC Post Pre Post Pre Post Pre Post Pre Miami 1A 2.2 2.2 11.8 12.4 0.4 0.4 11.1 11.1 Houston 2A 21.6 21.5 9.7 10.7 0.4 0.4 18.0 18.5 Phoenix 2B 21.4 21.2 11.2 13.2 0.4 0.4 13.6 15.6 Atlanta 3A 41.3 41.1 5.4 6.1 0.5 0.5 21.1 21.7 Los Angeles 3B 22.5 22.3 1.1 1.1 0.5 0.5 12.7 12.3 Las Vegas 3B 32.9 32.6 8.3 10.2 0.4 0.4 18.8 20.1 San Francisco 3C 50.0 48.4 0.3 0.3 0.5 0.5 13.2 13.1 Baltimore

  15. Buildings Energy Data Book: 3.8 Hospitals and Medical Facilities

    Buildings Energy Data Book [EERE]

    3 Energy Benchmarks for Existing Hospitals, by Selected City and End-Use (thousand Btu per square foot) IECC Post Pre Post Pre Post Pre Post Pre Miami 1A 34.6 40.7 88.9 85.4 1.8 1.8 20.0 21.0 Houston 2A 42.1 48.0 89.5 86.9 2.2 2.1 19.6 20.8 Phoenix 2B 42.2 48.6 82.1 80.2 2.0 1.9 20.7 21.9 Atlanta 3A 45.8 53.9 83.7 82.1 2.5 2.5 19.0 20.6 Los Angeles 3B 45.4 46.9 75.4 71.0 2.5 2.4 18.5 18.8 Las Vegas 3B 40.9 48.0 69.5 69.0 2.2 2.2 18.5 21.2 San Francisco 3C 49.2 52.8 66.5 64.1 2.8 2.7 17.1 18.0

  16. Buildings Energy Data Book: 3.8 Hospitals and Medical Facilities

    Buildings Energy Data Book [EERE]

    5 Energy Benchmarks for Existing Outpatient Buildings, by Selected City and End-Use (thousand Btu per square foot) IECC Post Pre Post Pre Post Pre Post Pre Miami 1A 65.4 60.3 69.6 61.9 0.7 0.7 24.6 23.9 Houston 2A 73.2 76.2 54.0 52.9 0.8 0.8 22.1 24.0 Phoenix 2B 79.1 79.8 54.7 52.9 0.7 0.7 23.8 25.3 Atlanta 3A 83.1 91.1 41.8 42.1 0.9 0.9 22.1 24.6 Los Angeles 3B 87.8 86.3 37.4 35.6 0.9 0.9 22.5 23.1 Las Vegas 3B 76.6 80.5 44.1 44.0 0.8 0.8 23.2 25.5 San Francisco 3C 85.0 93.4 25.0 24.7 1.0 1.0

  17. Buildings Energy Data Book: 3.9 Educational Facilities

    Buildings Energy Data Book [EERE]

    4 Energy Benchmarks for Existing Large Hotels, by Selected City and End-Use (thousand Btu per square foot) IECC Post Pre Post Pre Post Pre Post Pre Miami 1A 1.4 0.1 155.0 142.0 30.1 29.4 8.9 11.2 Houston 2A 7.1 1.9 119.9 117.9 38.1 37.1 8.8 10.8 Phoenix 2B 4.5 1.1 113.2 111.5 33.5 32.7 9.1 11.4 Atlanta 3A 13.1 3.8 91.3 88.5 45.7 44.6 8.8 10.5 Los Angeles 3B 3.1 0.7 77.5 74.9 44.3 43.1 8.9 10.4 Las Vegas 3B 7.4 2.2 78.9 83.0 39.0 38.0 9.0 11.2 San Francisco 3C 8.0 2.6 48.8 49.6 50.8 49.5 8.7 10.0

  18. Buildings Energy Data Book: 3.9 Educational Facilities

    Buildings Energy Data Book [EERE]

    7 Energy Benchmarks for Existing Small Hotels, by Selected City and End-Use (thousand Btu per square foot) IECC Post Pre Post Pre Post Pre Post Pre Miami 1A 0.2 0.0 25.7 21.2 5.6 5.4 6.7 2.6 Houston 2A 2.8 0.7 17.7 16.1 6.7 6.5 5.6 2.0 Phoenix 2B 2.0 0.2 18.7 17.0 6.0 5.9 6.2 2.3 Atlanta 3A 5.4 1.9 12.0 11.1 7.8 7.6 5.4 1.6 Los Angeles 3B 1.7 0.0 9.5 9.7 7.6 7.4 5.2 1.4 Las Vegas 3B 3.4 0.6 13.6 13.5 6.8 6.6 5.7 1.9 San Francisco 3C 4.4 0.3 5.8 6.1 8.5 8.3 4.5 0.9 Baltimore 4A 9.2 3.7 9.6 8.8

  19. Buildings Energy Data Book: 3.9 Educational Facilities

    Buildings Energy Data Book [EERE]

    1 Energy Benchmarks for Existing Secondary Schools, by Selected City and End-Use (thousand Btu per square foot) IECC Post Pre Post Pre Post Pre Post Pre Miami 1A 1.0 10.2 73.6 17.5 1.2 1.4 6.0 9.1 Houston 2A 9.5 7.0 49.7 20.7 1.5 1.3 5.2 10.9 Phoenix 2B 6.6 20.9 53.9 10.0 1.3 1.7 5.7 8.8 Atlanta 3A 18.7 5.8 31.4 5.2 1.7 1.6 5.0 7.3 Los Angeles 3B 5.7 11.5 25.2 14.4 1.7 1.5 5.0 10.3 Las Vegas 3B 10.5 15.8 34.7 1.7 1.5 1.8 5.3 7.5 San Francisco 3C 16.1 36.2 11.4 7.3 1.9 1.9 4.8 8.4 Baltimore 4A

  20. Buildings Energy Data Book: 3.9 Educational Facilities

    Buildings Energy Data Book [EERE]

    9 Energy Benchmarks for Existing Primary Schools, by Selected City and End-Use (thousand Btu per square foot) IECC Post Pre Post Pre Post Pre Post Pre Miami 1A 0.7 0.7 20.6 22.4 1.4 1.4 3.1 3.4 Houston 2A 6.4 8.3 13.3 17.2 1.7 1.7 2.4 2.9 Phoenix 2B 4.1 6.1 14.2 19.6 1.6 1.5 2.9 3.6 Atlanta 3A 12.5 16.8 7.6 10.6 2.0 2.0 2.1 2.7 Los Angeles 3B 4.4 4.4 6.1 6.6 1.9 1.9 2.2 2.4 Las Vegas 3B 6.6 10.2 10.1 14.5 1.8 1.7 2.6 3.4 San Francisco 3C 10.9 12.6 2.3 3.0 2.2 2.1 1.9 2.2 Baltimore 4A 18.6 29.8

  1. HIGH D{sub 2}O/HDO RATIO IN THE INNER REGIONS OF THE LOW-MASS PROTOSTAR NGC1333 IRAS2A

    SciTech Connect (OSTI)

    Coutens, A.; Jrgensen, J. K.; Persson, M. V.; Van Dishoeck, E. F.; Vastel, C.; Taquet, V.

    2014-09-01

    Water plays a crucial role both in the interstellar medium and on Earth. To constrain its formation mechanisms and its evolution through the star formation process, the determination of the water deuterium fractionation ratios is particularly suitable. Previous studies derived HDO/H{sub 2}O ratios in the warm inner regions of low-mass protostars. We here report a detection of the D{sub 2}O 1{sub 1,} {sub 0}-1{sub 0,} {sub 1} transition toward the low-mass protostar NGC1333 IRAS2A with the Plateau de Bure interferometer: this represents the first interferometric detection of D{sub 2}Oand only the second solar-type protostar for which this isotopologue is detected. Using the observations of the HDO 5{sub 4,} {sub 2}-6{sub 3,} {sub 3} transition simultaneously detected and three other HDO lines previously observed, we show that the HDO line fluxes are well reproduced with a single excitation temperature of 218 21K and a source size of ?0.''5. The D{sub 2}O/HDO ratio is ?(1.2 0.5)נ10{sup 2}, while the use of previous H{sub 2}{sup 18}O observations give an HDO/H{sub 2}O ratio of ?(1.7 0.8)נ10{sup 3}, i.e., a factor of seven lower than the D{sub 2}O/HDO ratio. These results contradict the predictions of current grain surface chemical models and indicate that either the surface deuteration processes are poorly understood or that both sublimation of grain mantles and water formation at high temperatures (?230K) take place in the inner regions of this source. In the second scenario, the thermal desorption of the grain mantles would explain the high D{sub 2}O/HDO ratio, while water formation at high temperature would explain significant extra production of H{sub 2}O leading to a decrease of the HDO/H{sub 2}O ratio.

  2. THE SYNTHESIS AND CRYSTAL STRUCTURE OF UCp{sub 3}(C{sub 3}H{sub 3}N{sub 2}). A NEW MODE OF PYRAZOLATE BONDING

    SciTech Connect (OSTI)

    Eigenbrot, Jr., Charles W.; Raymond, Kenneth N.

    1980-08-01

    The title compound has been prepared by the reaction of tris(cyclopentadienyl) uranium chloride (UCp{sub 3}Cl) and sodium pyrazolate (NaC{sub 3}H{sub 3}N{sub 2}) in tetrahydrofuran (THF). The compound has been characterized by its infrared, visible-near IR, pmr, and mass spectra; and by single crystal X-ray diffraction. The molecular structure consists of discrete UCp{sub 3}(C{sub 3}H{sub 3}N{sub 2}) molecules in which the uranium(IV) ion is coordinated by three {eta}{sup 5} Cp rings in a nearly trigonal array similar to that of other lanthanide and actinide MCp{sub 3}X structures. However, unlike these other structures, an eleven-coordinate geometry is achieved by having both the adjacent nitrogen atoms of the pyrazolate ring coordinate to the metal ion, such that the local twofold axis of the pyrazolate ring and the local threefold axis of the UCp{sub 3} fragment coincide. This is the first example of this type of endo-bidentate {eta}{sup 2} coordination for the pyrazolate anion. Red-brown crystals from toluene conform to space group P2{sub 1}/a (an alternate setting of P2{sub 1}/c) with a = 14.295(1), b = 8.383(1), c = 14.282(1) {angstrom}, S = 112.80(1) {degrees}, and there are four molecules per unit cell. For the 3631 independent reflections collected by counter methods with F{sup 2} > 3{sigma}(F{sup 2}). the final weighted and unweighted R factors are both 3.14 percent. The U-N distances are 2.40(1) and 2.36(1) {angstrom}. The average U-C distance of 2.76 {angstrom} is consistent with that predicted for an eleven-coordinate uranium(IV) cyclopentadienyl complex. The 90 MHz proton resonances of the Cp rings occur at -9.51 (35°C), -11.59 (-l0°C). -14.22 (-50°C), and -15.84 (-75°C) ppm. Susceptibility studies from 5 to 80 K show a temperature-independent paramagnetism from 7.5 to 37.1 K; above this temperature {mu}{sub eff} = 2.67 {mu}{sub B}·

  3. EA-1769: Final Environmental Assessment and Finding of No Significant Impact

    Broader source: Energy.gov [DOE]

    Houston Advanced Research Center, Battleground Energy Recovery Project, Deer Park, Harris County, Texas (October 2011)

  4. Thermally stable compositions including 2,4,8,10-tetranitro-5H-pyrido[3',2':4,5][1,2,3]triazolo[1,2-a]benzotriazo- l-6-ium, inner salt

    DOE Patents [OSTI]

    Hiskey, Michael A.; Huynh, My Hang

    2010-01-26

    An explosive formulation including 2,4,8,10-tetranitro-5H-pyrido[3',2':4,5][1,2,3]triazolo[1,2-a]benzotriazo- l-6-ium, inner salt and a high temperature binder is disclosed together with a process of preparing 2,4,8,10-tetranitro-5H-pyrido[3',2':4,5][1,2,3]triazolo[1,2-a]benzotriazo- l-6-ium, inner salt.

  5. Field Testing Unvented Roofs with Asphalt Shingles in Cold and Hot-Humid Climates

    SciTech Connect (OSTI)

    Ueno, Kohta; Lstiburek, Joseph W.

    2015-09-01

    Test houses with unvented roof assemblies were built to measure long-term moisture performance, in the Chicago area (5A) and the Houston area (2A). The Chicago-area test bed had seven experimental rafter bays, including a control vented compact roof, and six unvented roof variants with cellulose or fiberglass insulation. The interior was run at 50% RH. The Houston-area roof was an unvented attic insulated with spray-applied fiberglass. Most ridges and hips were built with a diffusion vent detail, capped with vapor permeable roof membrane. In contrast, the diffusion vent roofs had drier conditions at the roof peak in wintertime, but during the summer, RHs and MCs were higher than the unvented roof (albeit in the safe range).

  6. NERC_Interconnection_1A.pdf

    Office of Environmental Management (EM)

    National Environmental Policy Act of 1969, as amended (Pub. L. 91-190, 42 U.S.C. 4321-4347, January 1, 1970, as amended by Pub. L. 94-52, July 3, 1975, Pub. L. 94-83, August 9, 1975, and Pub. L. 97-258, § 4(b), Sept. 13, 1982) An Act to establish a national policy for the environment, to provide for the establishment of a Council on Environmental Quality, and for other purposes. Be it enacted by the Senate and House of Representatives of the United States of America in Congress assembled, That

  7. Mobile Source Enforcement Memorandum No. 1a

    Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

  8. Target_Chamber_1A.dra

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

  9. Second Annual Electric Power Research Institute/Sandia Photovoltaic Systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Chu Travels to Houston Sec. Chu Travels to Houston February 2, 2012 - 5:19pm Addthis The Houston Medical Center Thermal Energy Corporation Control Room. | Photo Courtesy of the Texas Medical Center The Houston Medical Center Thermal Energy Corporation Control Room. | Photo Courtesy of the Texas Medical Center Ginny Simmons Ginny Simmons Former Managing Editor for Energy.gov, Office of Public Affairs Secretary Chu traveled to Houston, Texas, today to meet with executives from various oil and gas

  10. National Renewable Energy Laboratory Environmental Performance Report for 2010 (Annual Site Environmental Report per the U.S. Department of Energy Order 231.1-1A Chg 2)

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Renewable Energy Laboratory Environmental Performance Report for 2010 (Annual Site Environmental Report per the U.S. Department of Energy Order 231.1-1A Chg 2) Prepared by Environment, Health, and Safety Office Management Report NREL/MP-1900-52498 September, 2011 NREL is a national laboratory of the U.S. Department of Energy, Office of Energy Efficiency & Renewable Energy, operated by the Alliance for Sustainable Energy, LLC. National Renewable Energy Laboratory 1617 Cole Boulevard Golden,

  11. G to A substitution in 5{prime} donor splice site of introns 18 and 48 of COL1A1 gene of type I collagen results in different splicing alternatives in osteogenesis imperfecta type I cell strains

    SciTech Connect (OSTI)

    Willing, M.; Deschenes, S.

    1994-09-01

    We have identified a G to A substitution in the 5{prime} donor splice site of intron 18 of one COL1A1 allele in two unrelated families with osteogenesis imperfecta (OI) type I. A third OI type I family has a G to A substitution at the identical position in intron 48 of one COL1A1 allele. Both mutations abolish normal splicing and lead to reduced steady-state levels of mRNA from the mutant COL1A1 allele. The intron 18 mutation leads to both exon 18 skipping in the mRNA and to utilization of a single alternative splice site near the 3{prime} end of exon 18. The latter results in deletion of the last 8 nucleotides of exon 18 from the mRNA, a shift in the translational reading-frame, and the creation of a premature termination codon in exon 19. Of the potential alternative 5{prime} splice sites in exon 18 and intron 18, the one utilized has a surrounding nucleotide sequence which most closely resembles that of the natural splice site. Although a G to A mutation was detected at the identical position in intron 48 of one COL1A1 allele in another OI type I family, nine complex alternative splicing patterns were identified by sequence analysis of cDNA clones derived from fibroblast mRNA from this cell strain. All result in partial or complete skipping of exon 48, with in-frame deletions of portions of exons 47 and/or 49. The different patterns of RNA splicing were not explained by their sequence homology with naturally occuring 5{prime} splice sites, but rather by recombination between highly homologous exon sequences, suggesting that we may not have identified the major splicing alternative(s) in this cell strain. Both G to A mutations result in decreased production of type I collagen, the common biochemical correlate of OI type I.

  12. Proceedings from a Workshop on Ecological Carrying Capacity of Salmonids in the Columbia River Basin : Measure 7.1A of the Northwest Power Planning Council`s 1994 Fish and Wildlife Program : Report 3 of 4, Final Report.

    SciTech Connect (OSTI)

    Johnson, Gary E.; Neitzel, D.A.; Mavros, William V.

    1996-05-01

    This report contains the proceedings of a workshop held during 1995 in Portland, Oregon. The objective of the workshop was to assemble a group of experts that could help us define carrying capacity for Columbia River Basin salmonids. The workshop was one activity designed to answer the questions asked in Measure 7.1A of the Council`s Fish and Wildlife Program. Based, in part, on the information we learned during the workshop we concluded that the approach inherent in 7.1A will not increase understanding of ecology, carrying capacity, or limiting factors that influence salmon under current conditions. Measure 7.1A requires a definition of carrying capacity and a list of determinants (limiting factors) of capacity. The implication or inference then follows that by asking what we know and do not know about the determinants will lead to research that increases our understanding of what is limiting salmon survival. It is then assumed that research results will point to management actions that can remove or repair the limiting factors. Most ecologists and fisheries scientists that have studied carrying capacity clearly conclude that this approach is an oversimplification of complex ecological processes. To pursue the capacity parameter, that is, a single number or set of numbers that quantify how many salmon the basin or any part of the basin can support, is meaningless by itself and will not provide useful information.

  13. Bison Wind 2A | Open Energy Information

    Open Energy Info (EERE)

    Facility Type Commercial Scale Wind Facility Status In Service Developer Minnesota Windpower Energy Purchaser Minnesota Windpower Location Northwest of New Salem ND Coordinates...

  14. Form 2A | Open Energy Information

    Open Energy Info (EERE)

    for Permit to Discharge Municipal Wastewater from New and Existing Publicly Owned Treatment Works, current through August 14, 2014. Published NA Year Signed or Took Effect...

  15. Climate Zone 2A | Open Energy Information

    Open Energy Info (EERE)

    County, Georgia McLennan County, Texas McMullen County, Texas Milam County, Texas Miller County, Georgia Mitchell County, Georgia Mobile County, Alabama Montgomery County,...

  16. Leaning Juniper 2A | Open Energy Information

    Open Energy Info (EERE)

    energy Facility Type Commercial Scale Wind Facility Status In Service Owner Iberdrola Renewables Developer Iberdrola Renewables Energy Purchaser Bonneville Power Admin Location...

  17. PNIC.F.F2a

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Task 3 - Chemical Mechanical Polishing The chemical mechanical polishing of ELO and non-ELO (before lift-off) of InP surfaces and GaAs surfaces would be investigated with various ...

  18. Mg II ABSORPTION SYSTEMS WITH W{sub 0} >= 0.1 A FOR A RADIO SELECTED SAMPLE OF 77 QUASI-STELLAR OBJECTS AND THEIR ASSOCIATED MAGNETIC FIELDS AT HIGH REDSHIFT

    SciTech Connect (OSTI)

    Bernet, M. L.; Miniati, F.; Lilly, S. J. E-mail: fm@phys.ethz.c

    2010-03-01

    We present a catalog of Mg II absorption systems obtained from high-resolution Ultraviolet and Visual Echelle Spectrograph/VLT data of 77 quasi-stellar objects in the redshift range 0.6 < z < 2.0, and down to an equivalent width W{sub 0} >= 0.1 A. The statistical properties of our sample are found to be in agreement with those from the previous work in the literature. However, we point out that the previously observed increase with redshift of partial derivN/partial derivz for weak absorbers pertains exclusively to very weak absorbers with W{sub 0} < 0.1 A. Instead, partial derivN/partial derivz for absorbers with W{sub 0} in the range 0.1-0.3 A actually decreases with redshift, similar to the case of strong absorbers. We then use this catalog to extend our earlier analysis of the links between the Faraday rotation measure (RM) of the quasars and the presence of intervening Mg II absorbing systems in their spectra. In contrast to the case with strong Mg II absorption systems (W{sub 0} > 0.3 A), the weaker systems do not contribute significantly to the observed RM of the background quasars. This is possibly due to the higher impact parameters of the weak systems compared to strong ones, suggesting that the high column density magnetized material that is responsible for the Faraday rotation is located within about 50 kpc of the galaxies. Finally, we show that this result also rules out the possibility that some unexpected secondary correlation between the quasar redshift and its intrinsic RM is responsible for the association of high RM and strong intervening Mg II absorption that we have presented elsewhere, since this would have produced an equal effect for the weak absorption line systems, which exhibit a very similar distribution of quasar redshifts.

  19. Manilla Bay 1, 1A, 1A sidetrack; success against all odds

    SciTech Connect (OSTI)

    Durkee, E.F.; Rillera, F.G. )

    1996-01-01

    The discovery of gas in Manila Bay is one of the more significant exploration discoveries in the Western Pacific in recent years. Within the Philippine Archipelago there is no better geographic or economic location to discover gas than at Manila Bay. Geologically, the well has proven that new concepts applied to old areas, in opposition to past beliefs and dogmas is still a valid way to find hydrocarbons. This is especially true re the western margin of the Central Valley of Luzon. New Venture reviewers (more than 100) were generally negative about the possibility of limestone objectives at this setting. The operators eventually drilled the prospect by themselves. The Manila Bay discovery well is on a large basement uplift with more than 2000 feet of vertical closure and 8,000 acres of areal closure at Miocene levels. The geological surprise was that the well drilled through a Pliocene Limestone (700 feet) charged with gas. An estimated in place resource of up to 2 TCF is possible. This is economically very significant for the Philippines as it is only 30 km from downtown Manila, a city of some 10 million people without any indigenous energy supply. Over-pressured fresh water sands induced drilling problems in the initial well MB-1AST and the deeper primary objectives in Middle to Lower Miocene, also predicted to be carbonates, were not reached. A second well to appraise the Pliocene and explore the deep zones will be drilled in early 1996.

  20. Manilla Bay 1, 1A, 1A sidetrack; success against all odds

    SciTech Connect (OSTI)

    Durkee, E.F.; Rillera, F.G.

    1996-12-31

    The discovery of gas in Manila Bay is one of the more significant exploration discoveries in the Western Pacific in recent years. Within the Philippine Archipelago there is no better geographic or economic location to discover gas than at Manila Bay. Geologically, the well has proven that new concepts applied to old areas, in opposition to past beliefs and dogmas is still a valid way to find hydrocarbons. This is especially true re the western margin of the Central Valley of Luzon. New Venture reviewers (more than 100) were generally negative about the possibility of limestone objectives at this setting. The operators eventually drilled the prospect by themselves. The Manila Bay discovery well is on a large basement uplift with more than 2000 feet of vertical closure and 8,000 acres of areal closure at Miocene levels. The geological surprise was that the well drilled through a Pliocene Limestone (700 feet) charged with gas. An estimated in place resource of up to 2 TCF is possible. This is economically very significant for the Philippines as it is only 30 km from downtown Manila, a city of some 10 million people without any indigenous energy supply. Over-pressured fresh water sands induced drilling problems in the initial well MB-1AST and the deeper primary objectives in Middle to Lower Miocene, also predicted to be carbonates, were not reached. A second well to appraise the Pliocene and explore the deep zones will be drilled in early 1996.

  1. Franck-Condon factors perturbed by damped harmonic oscillators: Solvent enhanced X {sup 1}A{sub g} ↔ A{sup 1}B{sub 1u} absorption and fluorescence spectra of perylene

    SciTech Connect (OSTI)

    Wang, Chen-Wen; Zhu, Chaoyuan Lin, Sheng-Hsien; Yang, Ling; Yu, Jian-Guo

    2014-08-28

    Damped harmonic oscillators are utilized to calculate Franck-Condon factors within displaced harmonic oscillator approximation. This is practically done by scaling unperturbed Hessian matrix that represents local modes of force constants for molecule in gaseous phase, and then by diagonalizing perturbed Hessian matrix it results in direct modification of Huang–Rhys factors which represent normal modes of solute molecule perturbed by solvent environment. Scaling parameters are empirically introduced for simulating absorption and fluorescence spectra of an isolated solute molecule in solution. The present method is especially useful for simulating vibronic spectra of polycyclic aromatic hydrocarbon molecules in which hydrogen atom vibrations in solution can be scaled equally, namely the same scaling factor being applied to all hydrogen atoms in polycyclic aromatic hydrocarbons. The present method is demonstrated in simulating solvent enhanced X {sup 1}A{sub g} ↔ A{sup 1}B{sub 1u} absorption and fluorescence spectra of perylene (medium-sized polycyclic aromatic hydrocarbon) in benzene solution. It is found that one of six active normal modes v{sub 10} is actually responsible to the solvent enhancement of spectra observed in experiment. Simulations from all functionals (TD) B3LYP, (TD) B3LYP35, (TD) B3LYP50, and (TD) B3LYP100 draw the same conclusion. Hence, the present method is able to adequately reproduce experimental absorption and fluorescence spectra in both gas and solution phases.

  2. Application of the Federal Petroleum Excise Tax to gas processors: Enron Gas Processing Company vs. United States of America (in the United States District Court for the Southern District of Texas, Houston Division)

    SciTech Connect (OSTI)

    Mintz, J.H.

    1996-12-31

    The Petroleum Excise Tax was established in 1980 as a tax on domestic refined crude oil and natural gasoline. The Government contends that natural gasoline produced by Enron in natural gas processing plants is refined natural gasoline, therefore these plants should be classed as refineries and the natural gasoline produced should be taxed at 14.7 cents per barrel. The government has an assessment of $643,594.33 for the six quarters beginning with the last quarter of 1991. Enron has filed a motion of Summary Judgment for these assessments to be dropped.

  3. miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer

    SciTech Connect (OSTI)

    Li, Qiaoyan; Zhu, Fufan; Chen, Puxiang

    2012-07-20

    Highlights: Black-Right-Pointing-Pointer Both miR-7 and miR-218 down-regulates HoxB3 expression by targeting the 3 Prime -UTR of HoxB3 mRNA. Black-Right-Pointing-Pointer A reverse correlation between the levels of endogenous miR-7, miR218 and HoxB3 expression. Black-Right-Pointing-Pointer Epigenetic changes involve in the reactivation of HoxB3. Black-Right-Pointing-Pointer Both miRNAs inhibits the cell cycle and clone formation of breast cancer cells. -- Abstract: Many microRNAs have been implicated as key regulators of cellular growth and differentiation and have been found to dysregulate proliferation in human tumors, including breast cancer. Cancer-linked microRNAs also alter the epigenetic landscape by way of DNA methylation and post-translational modifications of histones. Aberrations in Hox gene expression are important for oncogene or tumor suppressor during abnormal development and malignancy. Although recent studies suggest that HoxB3 is critical in breast cancer, the putative role(s) of microRNAs impinging on HoxB3 is not yet fully understood. In this study, we found that the expression levels of miR-7 and miR-218 were strongly and reversely associated with HoxB3 expression. Stable overexpression of miR-7 and miR-218 was accompanied by reactivation of tumor suppressor genes including RASSF1A and Claudin-6 by means of epigenetic switches in DNA methylation and histone modification, giving rise to inhibition of the cell cycle and clone formation of breast cancer cells. The current study provides a novel link between overexpression of collinear Hox genes and multiple microRNAs in human breast malignancy.

  4. Arsenic-related skin lesions and glutathione S-transferase P1 A1578G (lle105Val) polymorphism in two ethnic clans exposed to indoor combustion of high arsenic coal in one village

    SciTech Connect (OSTI)

    Lin, G.F.; Du, H.; Chen, J.G.; Lu, H.C.; Guo, W.C.; Meng, H.; Zhang, T.B.; Zhang, X.J.; Lu, D.R.; Golka, K.; Shen, J.H. [Chinese Academy of Sciences, Shanghai (China)

    2006-12-15

    A total of 2402 patients with arsenic-related skin lesions, such as hyperkeratosis, hyperpigmentation or hypopigmentation, or even skin cancer in a few villages in Southwest Guizhou Autonomous Prefecture, China represent a unique case of endemic arsenism related with indoor combustion of high arsenic coal. This study aimed to investigate the cluster of arsenism cases and the possible relevant factors including GSTP1 polymorphism in two clans of different ethnic origin living in one village for generations. Arsenism morbidity in Miao clan P was significantly lower than in the neighbouring Han clan G1 (5.9 vs. 32.7%, odds ratio (OR)=0.13, 95% confidence interval (CI): 0.06-0.27, P < 0.0001). No sex differences were confirmed inside both clans. Analyses of the environmental samples indicated that Miao clan P members were exposed to higher amounts of arsenic via inhalation and food ingestion. Hair and urine samples also proved a higher arsenic body burden in ethnic Miao individuals. No corresponding differences by sex were found. Higher frequencies of combined mutant genotype G/G1578 and A/G1578 (OR=4.72, 95% CI: 2.34-9.54, P < 0.0001) and of mutant allele G1578 (OR=3.22, 95% CI: 2.00-5.18, P < 0.0001) were detected in diagnosed arsenism patients than in non-diseased individuals. The Miao individuals showed a lower percentage of combined mutant genotypes (30.6 vs. 52.7%, OR=0.40, 95% CI: 0.19-0.84, P=0.015) as well as of mutant allele G1578 (OR=0.46, 95% CI: 0.24-0.88, P=0.017) than their Han neighbours. Conclusions Genetic predisposition influences dermal arsenism toxicity. The GSTP1 A1578G (IIe105Val) status might be a susceptibility factor for arsenic-related skin lesions.

  5. Final Scientific/Technical Report to the U.S. Department of Energy on NOVA's Einstein's Big Idea (Project title: E-mc2, A Two-Hour Television Program on NOVA)

    SciTech Connect (OSTI)

    Susanne Simpson

    2007-05-07

    Executive Summary A woman in the early 1700s who became one of Europe’s leading interpreters of mathematics and a poor bookbinder who became one of the giants of nineteenth-century science are just two of the pioneers whose stories NOVA explored in Einstein’s Big Idea. This two-hour documentary premiered on PBS in October 2005 and is based on the best-selling book by David Bodanis, E=mc2: A Biography of the World’s Most Famous Equation. The film and book chronicle the scientific challenges and discoveries leading up to Einstein’s startling conclusion that mass and energy are one, related by the formula E = mc2.

  6. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    CreatorsAuthors contains: "Department of Physics and TcSUH, University of Houston, ... NbCoSb Huang, Lihong ; Department of Physics and TcSUH, University of Houston, ...

  7. RRI Energy Inc formerly known as Reliant Energy Inc | Open Energy...

    Open Energy Info (EERE)

    Energy Inc Jump to: navigation, search Name: RRI Energy, Inc (formerly known as Reliant Energy Inc) Place: Houston, Texas Zip: 77002 Product: Houston-based, owner and operator of...

  8. GeoGreen Fuels LLC | Open Energy Information

    Open Energy Info (EERE)

    GeoGreen Fuels LLC Place: Houston, Texas Product: Houston-based developer of biodiesel plants in Texas. Coordinates: 29.76045, -95.369784 Show Map Loading map......

  9. CX-002240: Categorical Exclusion Determination

    Office of Energy Efficiency and Renewable Energy (EERE)

    Heavy Oil Viscous Pressure-Volume Temperature (PVT) - HoustonCX(s) Applied: B3.6Date: 05/13/2010Location(s): Houston, TexasOffice(s): Fossil Energy, National Energy Technology Laboratory

  10. Enron Documen'ts I.1

    Energy Savers [EERE]

    ... Mr. Kenneth L. Lay Enron Corporation - 1400 Smith Street Houston, TX 77002-7327 Dear Mr. ... President: William R. Klesse 4. Enron CorporationJ 1400 Smith St. Houston, TX. 77002-7327 ...

  11. CenterPoint Energy Low-Rise Multi Family Program

    Broader source: Energy.gov [DOE]

    Note: This Incentive is only available to customers in the CenterPoint Energy Houston electric territory.

  12. CenterPoint Energy- Residential and Small Commercial Efficiency Program

    Office of Energy Efficiency and Renewable Energy (EERE)

    Note: Rebate Incentives are only available to CenterPoint Energy electric customers in the greater Houston area, Texas.

  13. EA-1750: Final Environmental Assessment

    Office of Energy Efficiency and Renewable Energy (EERE)

    Smart Grid, Center for Commercialization of Electric Technology, Technology Solutions for Wind Integration in ERCOT, Houston, Texas

  14. EA-1750: Draft Environmental Assessment

    Office of Energy Efficiency and Renewable Energy (EERE)

    Smart Grid, Center for Commercialization of Electric Technology, Technology Solutions for Wind Integration in ERCOT, Houston, Texas

  15. National Fuel Cell and Hydrogen Energy Overview: Total Energy USA 2012

    Office of Energy Efficiency and Renewable Energy (EERE)

    Presentation by Sunita Satyapal at the Total Energy USA 2012 meeting in Houston, Texas, on November 27, 2012.

  16. Texas County, Missouri: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    Missouri Cabool, Missouri Houston, Missouri Licking, Missouri Mountain Grove, Missouri Plato, Missouri Raymondville, Missouri Summersville, Missouri Retrieved from "http:...

  17. Workplace Charging Challenge Partner: ABB, Inc.

    Broader source: Energy.gov [DOE]

    Joined the Challenge: June 2013Headquarters: Cary, NCCharging Locations: New Berlin, WI; Raleigh, NC; Houston, TXDomestic Employees: 20,000

  18. CenterPoint Energy- Commercial and Industrial Energy Efficiency Programs

    Broader source: Energy.gov [DOE]

    Note: This program only applies to electric customers of CenterPoint Energy in the greater Houston area, Texas.

  19. CenterPoint Energy Healthcare Energy Efficiency Program

    Broader source: Energy.gov [DOE]

    Note: Program is only available to electric customers in CenterPoint Energy's service territory (greater Houston, Texas area)

  20. Differential effects of five 'classical' scorpion {beta}-toxins on rNa{sub v}1.2a and DmNav1 provide clues on species-selectivity

    SciTech Connect (OSTI)

    Bosmans, Frank; Martin-Eauclaire, Marie-France; Tytgat, Jan . E-mail: Jan.Tytgat@pharm.kuleuven.be

    2007-01-01

    In general, scorpion {beta}-toxins have been well examined. However, few in-depth studies have been devoted to species selectivity and affinity comparisons on the different voltage-activated Na{sup +} channels since they have become available as cloned channels that can be studied in heterologous expression systems. As a result, their classification is largely historical and dates from early in vivo experiments on mice and cockroach and fly larvae. In this study, we aimed to provide an updated overview of selectivity and affinity of scorpion {beta}-toxins towards voltage-activated Na{sup +} channels of vertebrates or invertebrates. As pharmacological tools, we used the classic {beta}-toxins AaHIT, Css II, Css IV, Css VI and Ts VII and tested them on the neuronal vertebrate voltage-activated Na{sup +} channel, rNa{sub v}1.2a. For comparison, its invertebrate counterpart, DmNav1, was also tested. Both these channels were expressed in Xenopus laevis oocytes and the currents measured with the two-electrode voltage-clamp technique. We supplemented this data with several binding displacement studies on rat brain synaptosomes. The results lead us to propose a general classification and a novel nomenclature of scorpion {beta}-toxins based on pharmacological activity.

  1. Time-dependent quantum wave packet study of the Ar+H{sub 2}{sup +}{yields}ArH{sup +}+H reaction on a new ab initio potential energy surface for the ground electronic state (1{sup 2}A Prime )

    SciTech Connect (OSTI)

    Hu Mei; Liu Xinguo; Tan Ruishan; Li Hongzheng; Xu Wenwu

    2013-05-07

    A new global potential energy surface for the ground electronic state (1{sup 2}A Prime ) of the Ar+H{sub 2}{sup +}{yields}ArH{sup +}+H reaction has been constructed by multi-reference configuration interaction method with Davidson correction and a basis set of aug-cc-pVQZ. Using 6080 ab initio single-point energies of all the regions for the dynamics, a many-body expansion function form has been used to fit these points. The quantum reactive scattering dynamics calculations taking into account the Coriolis coupling (CC) were carried out on the new potential energy surface over a range of collision energies (0.03-1.0 eV). The reaction probabilities and integral cross sections for the title reaction were calculated. The significance of including the CC quantum scattering calculation has been revealed by the comparison between the CC and the centrifugal sudden approximation calculation. The calculated cross section is in agreement with the experimental result at collision energy 1.0 eV.

  2. Management and Independent Assessments Guide for Use with 10 CFR, Part 830, Subpart A, and DOE O 414.1C, Quality Assurance; DOE M 450.4-1, Integrated Safety Management System Manual; and DOE O 226.1A

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2013-04-18

    Management and Independent Assessments Guide for Use with 10 CFR, Part 830, Subpart A, and DOE O 414.1C, Quality Assurance; DOE M 450.4-1, Integrated Safety Management System Manual; and DOE O 226.1A

  3. Management and Independent Assessments Guide for Use with 10 CFR Part 830, Subpart A, and DOE O 414.1C, Quality Assurance; DOE M 450.4 -1, Integrated Safety Management System Manual; and DOE O 226.1A, Implementation of DOE Oversight Policy

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2007-09-27

    This Guide provides information on establishing processes for performing effective assessments. The revision to Guide reflects updated assessment practices, international standards, and changes in DOE expectations. Cancels DOE G 414.1-1A. Certified 11-18-10. Canceled by DOE G 414.1-1C.

  4. Notice of Intent to Revise DOE G 414.1-1B, Management and Independent Assessments Guide for Use with 10 CFR, Part 830, Subpart A, and DOE O 414.1C, Quality Assurance; DOE M 450.4-1, Integrated Safety Management System Manual; and DOE O 226.1A

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2013-04-18

    This memorandum provides justification for revising DOE G 414.1-1B, Management and Independent Assessments Guide for Use With 10 CFR, Part 830, Subpart A, and DOE O 414.1C, Quality Assurance; DOE M 450.4-1, Integrated Safety Management System Manual; and DOE O 226.1A, Implementation of Department of Energy Oversight Policy.

  5. Table 1a. Effective, Occupied, and Vacant Square Footage, 1992

    U.S. Energy Information Administration (EIA) Indexed Site

    12,100 944 92 Midwest 1,196 17,117 15,691 1,425 91 South 1,953 24,401 22,300 2,101 91 West 866 12,508 11,233 1,274 89 Energy Sources (more than one may apply) Electricity 4,590...

  6. CTVI-1-A Wholesale Power Rate Schedule | Department of Energy

    Office of Environmental Management (EM)

    Center Hill, Wolf Creek, Old Hickory, Cheatham, Barkley, J. Percy Priest, and Cordell Hull Projects (all of such projects being hereafter called collectively the "Cumberland...

  7. DOE/PPPO/03-0098&D1/A1

    Office of Environmental Management (EM)

    ... from blades, jagged metal, or splintering woodsiding Flying particles from metal, wood, ... medium (sand, glass beads, grit, or CO 2 pellets) suspended in an air spray to loosen and ...

  8. Recommendation 201: Cleanup of Tank W1-A

    Broader source: Energy.gov [DOE]

    ORSSAB recommends to DOE specific procedure at Liquid Low-Level Waste Pipelines Northern Characterization Study Area.

  9. C. A. Tulk,1, a) A. M. dos Santos...

    Office of Scientific and Technical Information (OSTI)

    ... New York, 2001). 18G. Greaves, F. Meneau, A. Sapelkin, L. Colyer, I. Gwynn, S. Wade, and G. Sankar, "The rheology of collapsing zeolites amorphized by temperature and ...

  10. Type 1a supernovae. (Conference) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    in the Cosmos held July 27 - August 1, 2008 in Mackinac Island, MI.; Related Information: Proposed for presentation at the 10th Symposium on Nuclei in the Cosmos held July 27 - ...

  11. NEW - DOE G 580.1-1A, Personal Property

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    This Guide provides non-regulatory guidance and information to assist DOE organizations and contractors in implementing the DOE-wide and site-specific personal property management programs.

  12. DRAFT - DOE G 580.1-1A, Personal Property

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    This Guide provides non-regulatory guidance and information to assist DOE organizations and contractors in implementing the DOE-wide and site-specific personal property management programs. It supplements the policy, requirements, and responsibilities information contained in the DOE Order cited above and clarifies the regulatory requirements contained in the Federal Property Management Regulation (FMR) and specific contracts.

  13. NEW - DOE O 227.1A, Independent Oversight Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    The order prescribes the requirements and responsibilities for the DOE Independent Oversight Program.

  14. Cancellation of DOE HQ O 344.1A

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2010-10-08

    Effectively immediately, HQ O 344.1, Parking, dated 11-2-01, is canceled as is Chg. 1 dated 11-19-04.

  15. Madelyn Creedon visits NNSS U1a underground complex | National...

    National Nuclear Security Administration (NNSA)

    Friday, February 13, 2015 - 9:34am NNSA Blog This week, NNSA Principal Deputy Administrator Madelyn Creedon visited the Nevada National Security Site (NNSS). She discussed ...

  16. Draft - DOE O 436.1A, Departmental Sustainability

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    The order defines requirements and responsibilities for managing sustainability DOE to ensure that the Department carries out its missions in a sustainable manner that addresses national energy security and global environmental challenges, and advances sustainable, efficient and reliable energy for the future; institute wholesale cultural change to factor sustainability and greenhouse gas (GHG) reductions into all DOE corporate management decisions; and ensure that DOE achieves the sustainability goals established in its Strategic Sustainability Performance Plan.

  17. Revision to Addendum to Mobile Source Enforcement Memorandum 1A

    Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

  18. DOE O 200.1A | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    bto_Nemtzow_090116.png By David Nemtzow, Acting Director I recently spoke with two distinct audiences about the importance of buildings in the U.S. energy space. Both the FEMP Energy Exchange conference and a group hosted by the Alliance to Save Energy had roomfuls of energy savvy professionals, many - but I suspect not all - of whom recognize the scope of opportunities the U.S. buildings sector offers for reducing energy consumption and greenhouse gas emissions. So let's start at the beginning:

  19. Maple Ridge 1a Wind Farm | Open Energy Information

    Open Energy Info (EERE)

    Developer PPM EnergyHorizon Wind Energy Energy Purchaser NYSERDAMarket Location Lewis County NY Coordinates 43.775565, -75.584614 Show Map Loading map......

  20. CV-1a: Magmatic - Extrusive | Open Energy Information

    Open Energy Info (EERE)

    95,000,000 W 95,000,000,000 mW 0.095 GW 9.5e-5 TW 503.15 K230 C 446 F 905.67 R Bac-Man Laguna Geothermal Area Philippine Island Arc Fault Intersection Volcanic 150 MW150,000...

  1. New England (PADD 1A) Gasoline and Diesel Retail Prices

    U.S. Energy Information Administration (EIA) Indexed Site

    79 2.237 2.219 2.270 2.305 2.309 1993-2016 All Grades - Conventional Areas 2.286 2.261 2.246 2.294 2.336 2.346 1994-2016 All Grades - Reformulated Areas 2.278 2.231 2.212 2.264 2.298 2.299 1994-2016 Regular 2.168 2.125 2.104 2.166 2.201 2.202 1993-2016 Conventional Areas 2.181 2.156 2.141 2.192 2.239 2.248 1993-2016 Reformulated Areas 2.165 2.117 2.095 2.160 2.192 2.191 1994-2016 Midgrade 2.441 2.404 2.391 2.410 2.449 2.455 1994-2016 Conventional Areas 2.439 2.416 2.401 2.439 2.471 2.481

  2. Shared Communications: Volume 1. A Summary and Literature Review

    SciTech Connect (OSTI)

    Franzese, O

    2004-09-22

    This paper provides a review of examples from the literature of shared communication resources and of agencies and/or organizations that share communication resources. The primary emphasis is on rural, intelligent transportation system communications involving transit. Citations will not be limited, however, to rural activities, or to ITS implementation, or even to transit. In addition, the term ''communication'' will be broadly applied to include all information resources. Literature references to issues that contribute to both successful and failed efforts at sharing communication resources are reviewed. The findings of this literature review indicate that: (1) The most frequently shared communication resources are information/data resources, (2) Telecommunications infrastructure and technologies are the next most frequently shared resources, (3) When resources are successfully shared, all parties benefit, (4) A few unsuccessful attempts of sharing resources have been recorded, along with lessons learned, (5) Impediments to sharing include security issues, concerns over system availability and reliability, service quality and performance, and institutional barriers, (6) Advantages of sharing include financial benefits to agencies from using shared resources and benefits to the public in terms of congestion mitigation, information transfer (e.g., traveler information systems), mobility (e.g., welfare-to-work paratransit), and safety (e.g., speed of incident response, incident avoidance), (7) Technology-based solutions exist to address technology-based concerns, and (8) Institutional issues can be addressed through leadership, enhanced knowledge and skills, open communication, responsiveness, and attractive pricing structures.

  3. DOE O 252.1A Technical Standards Program

    Broader source: Energy.gov [DOE]

    On February 23, 2011, the Department issued a Contractor Requirements Document (CRD) to the above listed Directive.

  4. Archived Reference Climate Zone: 1A Miami, Florida

    Broader source: Energy.gov [DOE]

    Here you will find past versions of the commercial reference building models for existing buildings constructed before 1980, organized by building type and location. A summary ofbuilding types and climate zones is available for reference. Current versions are also available.

  5. Archived Reference Climate Zone: 1A Miami, Florida

    Broader source: Energy.gov [DOE]

    Here you will find past versions of the commercial reference building models for existing buildings constructed in or after 1980, organized by building type and location. A summary of building types and climate zones is available for reference. Current versions are also available.

  6. H2A Hydrogen Production Analysis Tool (Presentation)

    Broader source: Energy.gov [DOE]

    Presented at the 2007 Bio-Derived Liquids to Hydrogen Distributed Reforming Working Group held November 6, 2007 in Laurel, Maryland.

  7. CHICO2 - A pixelated parallel-plate avalanche counter

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    shape transition and shape coexisting phenomenon in nuclei. CHICO consists of two mirror-image hemispheres with solid-angle coverage of 69% of 4 and each hemisphere holds 10...

  8. WPN 04-2a: Program Year 2004 Final Allocations

    Office of Energy Efficiency and Renewable Energy (EERE)

    To provide final state allocations to the states for their preparation and submission of applications for funding of the low-income Weatherization Assistance Program for Program Year 2004.

  9. Microsoft Word - Attachment G2A.doc

    Office of Environmental Management (EM)

    architectengineer for development of construction methods and supporting infrastructure, ... The architectengineers provide design drawings, construction methods and schedules as ...

  10. ,"Table 2a. Noncoincident Summer Peak Load, Actual and Projected...

    U.S. Energy Information Administration (EIA) Indexed Site

    Area Power Pool (MAPP) to Midwest Reliability Organization (MRO)." ," * The MRO, SERC, and SPP regional boundaries were altered as utilities changed reliability organizations. ...

  11. Energi E2 A S | Open Energy Information

    Open Energy Info (EERE)

    company which owns and operates CHP-based power stations in Denmark, hydroelectric power plants in Sweden and Norway as well as wind assets in Sweden, Greece and Spain....

  12. R. Driben,1,2,*A. V. Yulin,1and ...

    Office of Scientific and Technical Information (OSTI)

    ... Lett. QE-23, 510-524 (1987). 30. B. A. Malomed, "Perturbation-induced perestroika of a ... Nonlinear dynamics of solitary waves 1 is a broad and vibrant research area. ...

  13. ,"Table 2a. Noncoincident Summer Peak Load, Actual and Projected...

    U.S. Energy Information Administration (EIA) Indexed Site

    Noncoincident Summer Peak Load, Actual and Projected by North American Electric Reliability Corporation Region, " ,"2008 and Projected 2009 through 2013 " ,"(Megawatts and 2008 ...

  14. ,"Table 2a. Noncoincident Summer Peak Load, Actual and Projected...

    U.S. Energy Information Administration (EIA) Indexed Site

    Noncoincident Summer Peak Load, Actual and Projected by North American Electric Reliability Corporation Region, " ,"2009 and Projected 2010 through 2014 " ,"(Megawatts and 2009 ...

  15. ,"Table 2a. Noncoincident Summer Peak Load, Actual and Projected...

    U.S. Energy Information Administration (EIA) Indexed Site

    3 and Projected 2004 through 2008 " ,"(Megawatts and 2003 Base Year)",,,," " ,"Summer Noncoincident Peak Load",,"Contiguous U.S. ","Eastern Power Grid",,,..."Texas Power ...

  16. ,"Table 2a. Noncoincident Summer Peak Load, Actual and Projected...

    U.S. Energy Information Administration (EIA) Indexed Site

    a. Noncoincident Summer Peak Load, Actual and Projected by North American Electric Reliability Corporation Region, " ,"2006 and Projected 2007 through 2011 " ,"(Megawatts and 2006 ...

  17. ,"Table 2a. Noncoincident Summer Peak Load, Actual and Projected...

    U.S. Energy Information Administration (EIA) Indexed Site

    4 and Projected 2005 through 2009 " ,"(Megawatts and 2004 Base Year)",,,," " ,"Summer Noncoincident Peak Load",,"Contiguous U.S. ","Eastern Power Grid",,,..."Texas Power ...

  18. ,"Table 2a. Noncoincident Summer Peak Load, Actual and Projected...

    U.S. Energy Information Administration (EIA) Indexed Site

    a. Noncoincident Summer Peak Load, Actual and Projected by North American Electric Reliability Corporation Region, " ,"2007 and Projected 2008 through 2012 " ,"(Megawatts and 2007 ...

  19. Microsoft Word - 8E2A4440.doc

    Broader source: Energy.gov (indexed) [DOE]

    48D7DF19-707E-28B27A.doc (126.75 KB) More Documents & Publications Microsoft Word - ARRAAttachment12v1.doc Microsoft Word - Fact Sheet Energy Speech 082508 FINAL.doc Microsoft Word - GSP_Charter.doc

    Grant Amount Non-Fed Amount Project Location (City) Project Location (State) Description 1) Pilot and Demonstration Scale FOA - Pilot Scale Algenol Biofuels Inc. $25,000,000 $33,915,478 Freeport TX This project will make ethanol directly from carbon dioxide and seawater using algae. The

  20. The Biological Implications of the PP2A Crystal Structure

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    groups are not removed in needed situations) is associated with multiple human cancers, Alzheimer's Disease, and increased susceptibility to pathogen infections. To shed light on...

  1. trinity-aa-use-case-v1.2a

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    trident Trident The Trident glass laser system consists of three high-energy beams that can be delivered to two independent target experimental areas. Its long-pulse capabilities have led to innovations in unique loading techniques for material dynamics research. Its short pulse capability includes very high

    Trinity Use Case Scenarios ( SAND 2 013---2941 P U nclassified, U nlimited R elease) Page 1 of 9 Trinity / N ERSC---8 U se C ase S cenarios April 5 , 2 013 This d ocument p rovides a

  2. H2A Delivery Scenario Model and Analyses

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Marianne Mintz and Jerry Gillette DOE Hydrogen Delivery Analysis and High Pressure Tanks R&D Project Review Meeting February 8, 2005 2 Pioneering Science and Technology Office of ...

  3. Attachment L-2a Relevant Corporate Experience Form

    National Nuclear Security Administration (NNSA)

    ... Item 9. Insert the final sum of all invoices or the sum of all invoices to date, including agreed upon and disputed amounts, paid and awaiting payment. Item 10a. Insert the name, ...

  4. Microsoft Word - 8E2A4440.doc

    Broader source: Energy.gov (indexed) [DOE]

    ... risk register updatingstatus reporting, indirect cost rate, results, and impacts. ... financial, budgetary, procurement, and program information to monitor project execution. ...

  5. DOE O 475.2A Identifying Classified Information

    Office of Energy Efficiency and Renewable Energy (EERE)

    On February 1, 2011, the Department issued a Contractor Requirements Document (CRD) to the above listed Directive.

  6. ER CXD-Form-2011_Ver2a.pdf

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Electro-Refining Project (4624 (Rev.1)) Y-12 Site Office Oak Ridge Anderson County Tennessee The purpose of this project is to install and turnover to operations a process...

  7. H2A Delivery: Forecourt Compression & Storage Optimization (Part...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    f illing the vehicle. ***For all hoses 1 Moore, Graham; Chevron. 582007 3 6% 7% 8% 9% ... high output for many consecutive hours 2 Moore, Graham; Chevron. 582007 4 Modified ...

  8. Next Update: December 2011 Table 2a. Noncoincident Summer Peak...

    Gasoline and Diesel Fuel Update (EIA)

    found on the EIA web page for electric reliability. * Regional name and function has changed from Electric Reliability Council of Texas (ERCOT) to Texas Reliability Entity (TRE). ...

  9. A Literature Review, Bibliographic Listing, and Organization of Selected References Relative to Pacific salmon (Oncorhynchus spp.) and Abiotic and Biotic Attributes of the Columbia River Estuary and Adjacent Marine and Riverine Environs for Various Historical Periods : Measure 7.1A of the Northwest Power Planning Council`s 1994 Fish and Wildlife Program : Report 4 of 4, Final Report.

    SciTech Connect (OSTI)

    Costello, Ronald J.

    1996-05-01

    This report contains the results of a literature review on the carrying capacity of Pacific salmon in the Columbia River Basin. The objective of the review was to find the information gaps relative to the determinants of salmon carrying capacity in the Columbia River Basin. The review was one activity designed to answer questions asked in Measure 7.1A of the Councils Fish and Wildlife Program. Based, in part, on the information learned during the literature review and the other work accomplished during this study the Pacific Northwest National Laboratory (PNNL) state concluded that the approach inherent in 7.1A will not increase understanding of ecology, carrying capacity, or limiting factors that influence salmon under current conditions. To increase understanding of ecology, carring capacity, and limiting factors, it is necessary to deal with the complexity of the sustained performance of salmon in the Columbia River Basin. The PNNL team suggests that the regions evaluated carrying capacity from more than one view point. The PNNL team recommends that the region use the contextualistic view for evaluating capacity.

  10. Synthesis and structural characterization of new defect pyrochlore type A{sub x}Ln{sub y}Sb{sub 2}O{sub 6+z} antimoniates (01; A = Rb, Cs, Tl; Ln = Eu, Gd, and Y) prepared by coprecipitation

    SciTech Connect (OSTI)

    El Haimouti, A.; Zambon, D.; El-Ghozzi, M.; Avignant, D.; Leroux, F.; El Aatmani, M.; Daoud, M

    2003-07-14

    New cubic defect pyrochlore type A{sub x}Ln{sub y}Sb{sub 2}O{sub 6+z} antimoniates (01; A=Rb, Cs, Tl; Ln=Eu, Gd, and Y) (space group Fd3m) were prepared by calcination in air at 650 deg. C of compositions obtained by a coprecipitation method. Their crystal structures were refined by the Rietveld procedure and further confirmed by X-ray absorption spectroscopy (EXAFS) experiments. Refinements of the X-ray powder diffraction data show a partial and statistical occupation of the 8b site by alkaline or thallous ions and oxygen and lead to values close to 0.33 for the only refinable positional x parameter of the 48f oxygenated site.

  11. Register Now for April 12-13 Workshop on Improving Data Management for

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Regions for Select Spot Prices The following day-ahead natural gas and electricity prices, as reported by SNL Energy, are used to represent the following regions: Region Gas Point Used Power Point Used New England Algonquin Citygate Massachusetts Hub (ISONE) New York City Transco Zone 6-NY NYC Zone J (NYISO) Mid-Atlantic TETCO-M3 Western Hub (PJM) Midwest Chicago Citygate Illinois Hub (MISO) Louisiana Henry Hub Entergy (SNL index) Houston Houston Ship Channel Houston Zone (SNL index) Southwest

  12. Secretary Salazar and Secretary Chu to Meet with Scientists and Engineers

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    at BP Houston Command Center | Department of Energy Salazar and Secretary Chu to Meet with Scientists and Engineers at BP Houston Command Center Secretary Salazar and Secretary Chu to Meet with Scientists and Engineers at BP Houston Command Center May 11, 2010 - 12:00am Addthis Report oiled shoreline or request volunteer information: (866)-448-5816 Submit alternative response technology, services or products: (281) 366-551 Submit your vessel for the Vessel of Opportunity Program: (281)

  13. Best Practices: Escalation Rates

    Office of Environmental Management (EM)

    Best Practices Escalation Rates Hosted by: FEDERAL UTILITY PARTNERSHIP WORKING GROUP SEMINAR November 3-4, 2015 Houston, TX Federal Utility Partnership Working Group November 3-4, 2015 Houston, TX Federal Utility Partnership Working Group November 3-4, 2015 Houston, TX Best Practices: Escalation Rate Value of future energy savings * Provides purchasing power for implementing a robust, comprehensive and customized ECM set * Provides an option for paying back financing in the shortest possible

  14. URTAC Meeting - September 2012 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Unconventional Resources Technology Advisory Committee Meeting Tuesday, September 25, 2012 Hyatt North Houston North Sam Houston Parkway East Houston, TX Overview of "Section 999" and the Uncoventional Resources Technology Advisory Committee (108.67 KB) DOE Traditional Research and NETL Complementary Research Portfolio (3.83 MB) RPSEA Onshore Program: Project Results - Environment Safety (6.76 MB) URTAC Calendar and Next Steps (87.72 KB) More Documents & Publications URTAC Meeting

  15. EM-Sponsored Field Station Thrives as Classroom for Students...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Scott, an industrial technology and technology education major, and Taurean Houston, a mechanical engineering technology major, turned a back corner of the room into a project...

  16. DOE Advanced Scientific Advisory Committee (ASCAC): Workforce...

    Office of Scientific and Technical Information (OSTI)

    Scott A. 6 ; Sarkar, Vivek 7 ; Stahlberg, Eric 8 ; Vetter, Jeffrey S. 9 ; Williams, Dean 5 + Show Author Affiliations University of Houston Total SA Lawrence Berkeley ...

  17. Institute for Energy Research | Open Energy Information

    Open Energy Info (EERE)

    Energy Research Jump to: navigation, search Logo: Institute for Energy Research Name: Institute for Energy Research Address: 1415 S. Voss Rd. Place: Houston, Texas Zip: 77057...

  18. Combined Heat and Power System Enables 100% Reliability at Leading Medical Campus - Case Study

    SciTech Connect (OSTI)

    2013-03-29

    Case study of Thermal Energy Corporation (TECO) demonstrating a high-efficiency combined heat and power (CHP) system at Texas Medical Center in Houston, Texas

  19. Gulf Hydrocarbon Inc | Open Energy Information

    Open Energy Info (EERE)

    Houston, Texas Zip: 77002 Region: Texas Area Sector: Biofuels Product: Wholesale marketing of biodiesel and ethanol to refiners, blenders and petroleum distributors Website:...

  20. Tractebel Energy Marketing Inc | Open Energy Information

    Open Energy Info (EERE)

    Tractebel Energy Marketing Inc Jump to: navigation, search Name: Tractebel Energy Marketing Inc Address: 1177 West Loop South Suite 800 Place: Houston, TX Zip: 77027 Phone Number:...

  1. Third Planet Windpower (Texas) | Open Energy Information

    Open Energy Info (EERE)

    Windpower (Texas) Jump to: navigation, search Name: Third Planet Windpower Address: 909 Fannin Place: Houston, Texas Zip: 77010 Region: Texas Area Sector: Wind energy Product:...

  2. Sandia Energy Grid Integration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    efforts-during-recent-houston-press-conferencefeed 0 Recent Sandia Secure, Scalable Microgrid Advanced Controls Research Accomplishments http:energy.sandia.gov...

  3. Sandia Energy Energy Surety

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    efforts-during-recent-houston-press-conferencefeed 0 Recent Sandia Secure, Scalable Microgrid Advanced Controls Research Accomplishments http:energy.sandia.gov...

  4. Sandia Energy SMART Grid

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    efforts-during-recent-houston-press-conferencefeed 0 Recent Sandia Secure, Scalable Microgrid Advanced Controls Research Accomplishments http:energy.sandia.gov...

  5. Sandia Energy Distribution Grid Integration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    efforts-during-recent-houston-press-conferencefeed 0 Recent Sandia Secure, Scalable Microgrid Advanced Controls Research Accomplishments http:energy.sandia.gov...

  6. CenterPoint Energy A/C Distributor Program

    Broader source: Energy.gov [DOE]

    Note:  This incentive is only available to customers within CenterPoint Energy’s electric service territory (greater Houston area, Texas)

  7. Center for Advanced Solar Photophysics | Members

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    plexcitons Prof. Peter Nordlander Laboratory for Nanophotonics, Department of Physics and Astronomy and Electrical and Computer Engineering Rice University, Houston TX 77005, USA...

  8. Floating Windfarms Corporation | Open Energy Information

    Open Energy Info (EERE)

    Corporation Place: Houston, Texas Zip: 77060 Sector: Wind energy Product: Texas-based offshore wind power developer that uses floating and non-floating vertical axis wind...

  9. CenterPoint Energy | Open Energy Information

    Open Energy Info (EERE)

    Energy Place: Houston, Texas Service Territory: Texas Website: www.centerpointenergy.comhome Twitter: @CNPalerts Outage Hotline: 800-332-7143 Outage Map: gis.centerpointenergy.co...

  10. Betabatt Inc | Open Energy Information

    Open Energy Info (EERE)

    Inc Jump to: navigation, search Name: Betabatt, Inc. Place: Houston, Texas Product: Battery manufacturer using a patented 3D energy conversion architecture named the DECTM Cell,...

  11. Power Technology Inc | Open Energy Information

    Open Energy Info (EERE)

    Inc Place: Houston, Texas Zip: 77024 Product: R&D company focused on alternative battery technology. Coordinates: 29.76045, -95.369784 Show Map Loading map......

  12. Calibration of an interfacial force microscope for MEMS metrology...

    Office of Scientific and Technical Information (OSTI)

    uncertainty in each method. Authors: Houston, Jack E. ; Baker, Michael Sean ; Crowson, Douglas A. ; Mitchell, John Anthony ; Moore, Nathan W. Publication Date: 2009-10-01 OSTI...

  13. Universal GeoPower | Open Energy Information

    Open Energy Info (EERE)

    GeoPower Jump to: navigation, search Name: Universal GeoPower Place: Houston, Texas Zip: 77007 Sector: Geothermal energy Product: A Texas-based geothermal development company....

  14. Chevron Technology Ventures LLC | Open Energy Information

    Open Energy Info (EERE)

    LLC Jump to: navigation, search Name: Chevron Technology Ventures LLC Address: 3901 Briarpark Drive Place: Houston Zip: 77042 Region: United States Sector: Marine and Hydrokinetic...

  15. EIS_Summary

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... Des Arc Austin Adona Houston Danville Palestine Perry Corinth Ward Cotton Plant ... Haynes Wheatley Fargo Horseshoe Lake Des Arc Hughes Palestine Ward Cotton Plant Forrest ...

  16. Gulf Alternative Energy Corporation | Open Energy Information

    Open Energy Info (EERE)

    Houston, Texas Zip: 77055 Product: Texas-based firm that has developed a cellulosic ethanol processing technology and plans to retrofit existing ethanol plants. Coordinates:...

  17. Gulf Ethanol Corp | Open Energy Information

    Open Energy Info (EERE)

    Gulf Ethanol Corp Jump to: navigation, search Name: Gulf Ethanol Corp Place: Houston, Texas Zip: 77055 Sector: Biomass Product: Focused on developing biomass preprocessing...

  18. Building America Whole-House Solutions for New Homes: Devoted...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Cold Climates DOE Zero Energy Ready Home: Durable Energy Builders, Houston, Texas Building America Whole-House Solutions for New Homes: Nelson Construction, Farmington, Connecticut

  19. Workshop on Scientific Directions at the Advanced Light Source...

    Office of Scientific and Technical Information (OSTI)

    Authors: Plummer, Ward E. ; Awschalom, David ; Russell, T. ; Cohen, M. ; Somorjai, G. ; Brown, Jr., Gordon E. ; Fleming, Graham ; Greene, C. ; Houston, Paul L. ; Smith, Neville V. ...

  20. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    ... E. ; Awschalom, David ; Russell, T. ; Cohen, M. ; Somorjai, G. ; Brown, Jr., Gordon E. ; Fleming, Graham ; Greene, C. ; Houston, Paul L. ; Smith, Neville V. No abstract prepared. ...

  1. Natural Gas Weekly Update

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    in Alberta, Chicago Citygate, Houston Ship Channel, San Juan Basin, Southern California border, Transco Zone 6, Northwest Pipeline Rockies, and Panhandle Eastern Pipe Line Co....

  2. Natural Gas Weekly Update, Printer-Friendly Version

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    in Alberta, Chicago Citygate, Houston Ship Channel, San Juan Basin, Southern California border, Transco Zone 6, Northwest Pipeline Rockies, and Panhandle Eastern Pipe Line Co....

  3. Green River Biodiesel Incorporated | Open Energy Information

    Open Energy Info (EERE)

    River Biodiesel Incorporated Jump to: navigation, search Name: Green River Biodiesel Incorporated Place: Houston, Texas Zip: 77056 Product: Biodiesel project developer and...

  4. Organic fuels | Open Energy Information

    Open Energy Info (EERE)

    to: navigation, search Name: Organic fuels Place: Houston, Texas Zip: 77056 Product: Biodiesel producer and distributor Coordinates: 29.76045, -95.369784 Show Map Loading...

  5. Ecowatt Design LLC | Open Energy Information

    Open Energy Info (EERE)

    Ecowatt Design LLC Jump to: navigation, search Logo: Ecowatt Design LLC Name: Ecowatt Design LLC Address: 10900 Northwest Fwy Place: Houston, Texas Zip: 77092 Region: Texas Area...

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    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... Dry ice cold spot other insl. Dry ice Unknowns Fatigue and impact behavior both at low ... tank and materials testing Ford Motor Company: Mike Veenstra, Dan Houston ...

  7. Tax Credits, Rebates & Savings | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    to CenterPoint Energy electric customers in the greater Houston area, Texas. Eligibility: Nonprofit, Residential, Federal Government, InstallersContractors, Retail Supplier...

  8. EDP Renewables North America | Open Energy Information

    Open Energy Info (EERE)

    EDP Renewables North America Jump to: navigation, search Name: EDP Renewables North America Address: 808 Travis St, Suite 700 Place: Houston, Texas Zip: 77002 Region: Texas Area...

  9. Elster | Open Energy Information

    Open Energy Info (EERE)

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  10. Aspen Pipeline | Open Energy Information

    Open Energy Info (EERE)

    navigation, search Name: Aspen Pipeline Place: Houston, Texas Zip: 77057 Product: US firm which acquires, builds and owns pipelines, gathering systems and distribution systems....

  11. Terrawatt Corporation | Open Energy Information

    Open Energy Info (EERE)

    Jump to: navigation, search Name: Terrawatt Corporation Place: Houston, Texas Zip: 77027 Sector: Geothermal energy Product: TerraWatt is solely focused on developing industrial...

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    U.S. Energy Information Administration (EIA) Indexed Site

    ... data beginning in 1949 and monthly data beginning in 1973. Sources: * Rotary Rigs in Operation: Baker Hughes, Inc., Houston, TX, "North America Rig Count," used with permission. ...

  13. CX-009587: Categorical Exclusion Determination

    Office of Energy Efficiency and Renewable Energy (EERE)

    City of Houston, Texas CX(s) Applied: B5.1 Date: 12/12/2012 Location(s): Texas Offices(s): Golden Field Office

  14. Energy Visions Prize | OpenEI Community

    Open Energy Info (EERE)

    Prize (EVP) competition will attend the Cleanweb Hackathons in NYC, Houston and SXSW Eco in Austin to preview innovative clean energy apps and encourage nominations. The EVP...

  15. Criteria for Selection of Seed Motions to Envelop Design Response Spectra

    Broader source: Energy.gov [DOE]

    Criteria for Selection of Seed Motions to Envelop Design Response Spectra DOE Natural Phenomena Hazards Workshop October 25, 2011 Michael Costantino, Thomas Houston, Greg Mertz, Andrew Maham

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    Office of Scientific and Technical Information (OSTI)

    Numerical Simulation Capabilities for In Situ Heating of Oil Shale Hoda, Nazish ExxonMobil Upstream Research Company, Houston, TX, USA; Fang, Chen ExxonMobil Upstream Research...

  17. DKRW Advanced Fuels LLC | Open Energy Information

    Open Energy Info (EERE)

    Fuels LLC Place: Houston, Texas Zip: 77056 Product: Focues on projects that utilise coal gasification technology, including coal-to-liquids, methanation, and integrated coal...

  18. Tax Credits, Rebates & Savings | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    only applies to electric customers of CenterPoint Energy in the greater Houston area, Texas. Eligibility: Commercial, Industrial, Local Government, Nonprofit, Schools, State...

  19. Tax Credits, Rebates & Savings | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

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  20. Veolia Energy | Open Energy Information

    Open Energy Info (EERE)

    Energy 1 Veolia Energy is a company located in Oklahoma City, with offices in Cambridge (Massachusetts), Houston, Boston, and New York City. Veolia Energy is a large...

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    Office of Scientific and Technical Information (OSTI)

    R.; Beddar, S. Departments of Radiation Physics, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030 (United States); Departments of Radiation Oncology,...

  2. "Title","Creator/Author","Publication Date","OSTI Identifier...

    Office of Scientific and Technical Information (OSTI)

    of Michigan, Ann Arbor, MI (United States); Mackin, D; Beddar, S MD Anderson Cancer Center, Houston, TX (United States); Zheng, Y Procure Proton Therapy Center,...

  3. TITLE AUTHORS SUBJECT SUBJECT RELATED DESCRIPTION PUBLISHER AVAILABILI...

    Office of Scientific and Technical Information (OSTI)

    United States Therriault Proulx F Yang J Beddar S University of Texas MD Anderson Cancer Center Houston TX United States ISOTOPES AND RADIATION SOURCES COLLIMATORS IONIZATION...

  4. Verification of proton range, position, and intensity in IMPT...

    Office of Scientific and Technical Information (OSTI)

    R.; Beddar, S. Departments of Radiation Physics, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030 (United States); Departments of Radiation Oncology,...

  5. SU-E-T-476: Quality Assurance for Gamma Knife Perfexion Using...

    Office of Scientific and Technical Information (OSTI)

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    Office of Scientific and Technical Information (OSTI)

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    Office of Scientific and Technical Information (OSTI)

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    Office of Scientific and Technical Information (OSTI)

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    Office of Scientific and Technical Information (OSTI)

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    Office of Scientific and Technical Information (OSTI)

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  11. Cavallo Energy | Open Energy Information

    Open Energy Info (EERE)

    Services, Solar Product: Houston-based energy management, finance procurement and engineering company. The firm offers engineering services to solar projects. References:...

  12. Microsoft Word - UEC-CC_020315_min_TEH.docx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (Imperial College, London); Megan Robertson (U. Houston); Ray Unocic (ORNLCNMS); Rafael Verduzco (Rice U.) Past Chair, ex officio member - Vivek Prabhu (NIST) CNMS...

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    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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