National Library of Energy BETA

Sample records for 111b 111b 111b

  1. VEGF111b, a new member of VEGFxxxb isoforms and induced by mitomycin C, inhibits angiogenesis

    SciTech Connect (OSTI)

    Gu, Fang; Li, Xiuli; Kong, Jian; Pan, Bing; Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides of Health Ministry, Beijing ; Sun, Min; Zheng, Lemin; Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides of Health Ministry, Beijing ; Yao, Yuanqing

    2013-11-08

    Highlights: We discovered a new member of VEGFxxxb family-VEGF111b. We found VEGF111b mRNA and protein can be induced by mitomycin C. We confirmed VEGF111b over-expression inhibits angiogenesis. VEGF111b inhibits angiogenesis through inhibiting VEGF-R2/PI3K/Akt and VEGF-R2/ERK1/2 phosphorylation. -- Abstract: Vascular endothelial growth factor (VEGF-A) stimulating angiogenesis is required for tumor growth and progression. The conventional VEGF-A isoforms have been considered as pro-angiogenic factors. Another family of VEGF-A isoforms generated by alternative splicing, termed VEGFxxxb isoforms, has anti-angiogenic property, exemplified by VEGF165b. Here, we identify a new number of VEGFxxx family-VEGF111b induced by mitomycin C, although not detected in mitomycin C-unexposed ovarian cancer cells. SKOV3 cells were transfected with pcDNA{sub 3.1} empty vector, pcDNA{sub 3.1}-VEGF111b or pcDNA{sub 3.1}-VEGF165b to collect conditioned mediums respectively. VEGF111b overexpression inhibits proliferation, migration and tube formation of endothelial cell by inhibiting VEGF-R2 phosphorylation and its downstream signaling, similar to VEGF165b but slightly lower than VEGF165b. The anti-angiogenic property depends on the six amino acids of exon 8b of the VEGFxxxb isoforms. Our results show that VEGF111b is a novel potent anti-angiogenic agent that can target the VEGF-R2 and its signaling pathway to inhibit ovarian tumor growth.

  2. FIVE NEW TRANSIT EPOCHS OF THE EXOPLANET OGLE-TR-111b

    SciTech Connect (OSTI)

    Hoyer, S.; Rojo, P.; Lopez-Morales, M.; DIaz, R. F.; Chambers, J.; Minniti, D. E-mail: pato@das.uchile.cl E-mail: diaz@iap.fr E-mail: dante@astro.puc.cl

    2011-05-20

    We report five new transit epochs of the extrasolar planet OGLE-TR-111b, observed in the v-HIGH and Bessell I bands with the FORS1 and FORS2 at the ESO Very Large Telescope between 2008 April and May. The new transits have been combined with all previously published transit data for this planet to provide a new transit timing variations (TTVs) analysis of its orbit. We find no TTVs with amplitudes larger than 1.5 minutes over a four-year observation time baseline, in agreement with the recent result by Adams et al. Dynamical simulations fully exclude the presence of additional planets in the system with masses greater than 1.3, 0.4, and 0.5 M{sub +} at the 3:2, 1:2, and 2:1 resonances, respectively. We also place an upper limit of about 30 M{sub +} on the mass of potential second planets in the region between the 3:2 and 1:2 mean-motion resonances.

  3. Summary of AEO2016 Electricity Working Group Meeting

    U.S. Energy Information Administration (EIA) Indexed Site

    ... emissions from affected plants and increase generation from clean sources. ... a 111(b) new source compliant coal generating technology in AEO2016. EIA responded that the ...

  4. Annual Energy Outlook 2016 2nd Coal Working Group

    U.S. Energy Information Administration (EIA) Indexed Site

    Gas-AEO2015 Reference Gas-2015 EIA Clean Power Plan Study WORKING GROUP ...issues - Need for a 111b compliant coal technology - Lack of differentiation between ...

  5. Annual Energy Outlook 2016 Renewables Working Group Preliminary...

    U.S. Energy Information Administration (EIA) Indexed Site

    TO CHANGE. AEO2016 Reference case final Clean Power Plan must assume some policy ...issues - Need for a 111b compliant coal technology - Lack of differentiation between ...

  6. EPA Regulation Compliance | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Mercury and Air Toxics Standards for Electric Generation Units - MATS Cross State Air Pollution Rule - CSAPR Carbon Pollution Standards for New Power Plants - 111(b) Carbon ...

  7. file://L:\\DOE-hanford.gov\\public\\boards\\hab\\advice\\advice60.htm

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    111-B Decontamination Station, the 115-B Gas Line PressureVacuum Seal House, the 118-C-4 (105-C) Horizontal Control Rod Cave and the 119-B Exhaust Air Sampler Building. The EE...

  8. CX-004254: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Seven Mile ProjectCX(s) Applied: B1.11, B4.6, B4.11Date: 10/07/2010Location(s): Linn County, OregonOffice(s): Bonneville Power Administration

  9. CX-003623: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Routine Grounds and Maintenance ActivitiesCX(s) Applied: B1.3, B1.11, B1.15Date: 08/24/2010Location(s): IllinoisOffice(s): Science, Argonne Site Office

  10. CX-006595: Categorical Exclusion Determination

    Office of Energy Efficiency and Renewable Energy (EERE)

    Routine Monitoring and Maintenance, Sherwood, Washington, Disposal SiteCX(s) Applied: B1.3, B1.11, B3.1Date: 08/29/2011Location(s): Sherwood, WashingtonOffice(s): Legacy Management

  11. CX-008009: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Safety and Security Component Installation and Alteration CX(s) Applied: B1.11, B2.2 Date: 11/28/2011 Location(s): Washington Offices(s): Science, Pacific Northwest Site Office

  12. CX-004731: Categorical Exclusion Determination

    Office of Energy Efficiency and Renewable Energy (EERE)

    858 Limited Area ExpansionCX(s) Applied: B1.11, B1.13Date: 11/01/2010Location(s): New MexicoOffice(s): Sandia Site Office

  13. CX-010774: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Iona Relay Station Maintenance CX(s) Applied: B1.3, B1.11, B2.5 Date: 07/25/2013 Location(s): Idaho Offices(s): Nuclear Energy

  14. CX-011198: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Office of Secure Transportation Construction of Permitted Area Boundary Fence and Vehicle Entrapment Gates CX(s) Applied: B1.11, B1.3, B1.15, B2.2 Date: 07/02/2013 Location(s): Tennessee Offices(s): Oak Ridge Office

  15. CX-013453: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Pueblo Canyon Grade Control Structure Revitalization and Wetlands Stabilization, TA-74 CX(s) Applied: B1.3, B1.11, B1.13, B3.1, B6.1Date: 02/18/2015 Location(s): New MexicoOffices(s): Los Alamos Site Office

  16. CX-005886: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Routine Monitoring, Maintenance, General Site Actions, and Non-Routine Actions at the Edgemont, South Dakota Disposal SiteCX(s) Applied: B1.3, B1.11, B1.24Date: 05/17/2011Location(s): Edgemont, South DakotaOffice(s): Legacy Management

  17. CX-013457: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Maintenance and Related Activities at the Burris Park, California Site CX(s) Applied: B1.3, B1.11, B1.24, B3.1, B6.1Date: 03/11/2015 Location(s): CaliforniaOffices(s): Legacy Management

  18. CX-000568: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Neutron imaging of metal hydride beds at Oak Ridge National Laboratory, Spallation Neutron SourceCX(s) Applied: B1.11, B1.13, B3.6Date: 12/30/2009Location(s): TennesseeOffice(s): Sandia Site Office

  19. CX-007443: Categorical Exclusion Determination

    Office of Energy Efficiency and Renewable Energy (EERE)

    Routine Site Activities at the Shirley Basin South, Wyoming, Disposal Site CX(s) Applied: B1.3, B1.11, B1.20, B3.1 Date: 12/13/2011 Location(s): Wyoming Offices(s): Legacy Management

  20. CX-005682: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Routine Monitoring, Maintenance, Research, General Site, and Administrative Actions at the Shiprock, New Mexico, Disposal SiteCX(s) Applied: A1, A8, B1.3, B1.11, B1.20, B3.1Date: 04/14/2011Location(s): Shiprock, New MexicoOffice(s): Legacy Management

  1. CX-011847: Categorical Exclusion Determination | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    CX-011847: Categorical Exclusion Determination Routine Maintenance Activities CX(s) Applied: B1.3, B1.4, B1.5, B1.6, B1.7, B1.8, B1.11, B1.13, B1.15, B1.16, B1.17, B1.21, B1.22, ...

  2. CX-011219: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Office of Secure Transportation Multiple Actions CX(s) Applied: B1.2, B1.3, B1.11, B1.15 Date: 09/25/2013 Location(s): Tennessee Offices(s): Oak Ridge Office

  3. CX-007519: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Waste Management Construction Support CX(s) Applied: B1.3, B1.11, B1.23, B1.24, B1.27, B1.28, B1.29, B1.31, B2.1 Date: 12/15/2011 Location(s): Tennessee Offices(s): Y-12 Site Office

  4. LM 03-15 | Department of Energy

    Energy Savers [EERE]

    3-15 LM 03-15 NEPA ID: LM 03-15 Short Title: Maintenance and Related Activities at the Burris Park, California, Site, LM 03-15 Determination: B1.3, B1.11, B1.24, B3.1, B6.1 PDF icon LM 03-15 More Documents & Publications CX-013457: Categorical Exclusion Determination CX-012199: Categorical Exclusion Determination LM 04-14

  5. CX-006222: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Non Comprehensive Environmental Response, Compensation, and Liability Act Permit Related, General Site Actions, and Non-Routine Actions at the Rocky Flats Site, Colorado, LM 18 - 11CX(s) Applied: B1.3, B1.11, B1.12, B1.24, B3.3Date: 06/24/2011Location(s): Jefferson County, ColoradoOffice(s): Legacy Management

  6. CX-013668: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Operations, Maintenance, Repairs, Modifications, and Ongoing CERCLA Remedy-Related Actions and Site Facility Support Activities for the Monticello, Utah, Sites CX(s) Applied: B1.3, B1.11, B1.24, B1.26, B1.33, B2.5, B3.1, B6.1Date: 03/31/2015 Location(s): UtahOffices(s): Legacy Management

  7. CX-009806: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    C-CA-CAM Building Complex Demolition and Site Restoration CX(s) Applied: B1.11, B1.16, B1.17, B1.23, B1.24, B1.27, B1.30, B1.33, B1.34 Date: 01/09/2013 Location(s): Pennsylvania Offices(s): Naval Nuclear Propulsion Program

  8. CX-008816: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Renovations and Maintenance Activities for Buildings, Structures, Infrastructures and Equipment CX(s) Applied: B1.3, 61.4, 61.5, B1.11, B1.15, B1.16, B1.17, 81.22, B1.27, 62.1, B2.2, B2.3, 62.5 Date: 06/08/2012 Location(s): Illinois Offices(s): New Brunswick Laboratory

  9. LM 07-15 | Department of Energy

    Energy Savers [EERE]

    5 LM 07-15 NEPA ID: LM 07-15 Short Title: Operations, Maintenance, Repairs, Modifications, and Ongoing CERCLA Remedy-Related Actions and Site Facility Support Activities for the Monticello, Utah, Sites Determination: B1.3; B1.11; B1.24; B1.26; B1.33; B2.5; B3.1; B6.1 PDF icon LM 07-15 More Documents & Publications CX-013668: Categorical Exclusion Determination LM 06-15 LM 13-14

  10. CX-011234: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Construction and Maintenance Activities at Existing Field Offices and Operation Centers CX(s) Applied: B1.3, B1.4, B1.11, B1.16, B1.17, B1.27, B1.31, B1.33, B1.34, B2.2, B2.3, B2.5, B4.7, B5.1, B5.16, B5.17, B5.23 Date: 10/17/2013 Location(s): CX: none Offices(s): Western Area Power Administration-Rocky Mountain Region

  11. CX-000787: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Generic Categorical Exclusion for Site-Wide Miscellaneous Installation and Maintenance ActivitiesCX(s) Applied: B1.3, B1.4, B1.5, B1.9, B1.11, B1.15, B1.16, B1.17, B1.22, B1.27, B1.31, B2.1, B2.2, B2.3, B2.5Date: 02/08/2010Location(s): IllinoisOffice(s): Science, Argonne Site Office

  12. Structure and electrical characterization of gallium arsenide nanowires with different V/III ratio growth parameters

    SciTech Connect (OSTI)

    Muhammad, R.; Ahamad, R.; Ibrahim, Z.; Othaman, Z.

    2014-03-05

    Gallium arsenide (GaAs) nanowires were grown vertically on GaAs(111)B substrate by gold-assisted using metal-organic chemical vapour deposition. Field-emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM) and conductivity atomic force microscopy (CAFM) analysis were carried out to investigate the effects of V/III ratio on structural properties and current-voltage changes in the wires. Results show that GaAs NWs grow preferably in the wurtzite crystal structure than zinc blende crystal structure with increasing V/III ratio. Additionally, CAFM studies have revealed that zincblende nanowires indicate ohmic characteristic compared to oscillation current occurred for wurtzite structures. The GaAs NWs with high quality structures are needed in solar cells technology for trapping energy that directly converts of sunlight into electricity with maximum capacity.

  13. Analysis of vapor-liquid-solid mechanism in Au-assisted GaAs nanowire growth

    SciTech Connect (OSTI)

    Harmand, J.C.; Patriarche, G.; Pere-Laperne, N.; Merat-Combes, M-N.; Travers, L.; Glas, F.

    2005-11-14

    GaAs nanowires were grown by molecular-beam epitaxy on (111)B oriented surfaces, after the deposition of Au nanoparticles. Different growth durations and different growth terminations were tested. After the growth of the nanowires, the structure and the composition of the metallic particles were analyzed by transmission electron microscopy and energy dispersive x-ray spectroscopy. We identified three different metallic compounds: the hexagonal {beta}{sup '}Au{sub 7}Ga{sub 2} structure, the orthorhombic AuGa structure, and an almost pure Au face centered cubic structure. We explain how these different solid phases are related to the growth history of the samples. It is concluded that during the wire growth, the metallic particles are liquid, in agreement with the generally accepted vapor-liquid-solid mechanism. In addition, the analysis of the wire morphology indicates that Ga adatoms migrate along the wire sidewalls with a mean length of about 3 {mu}m.

  14. Magnetoresistance effects and spin-valve like behavior of an arrangement of two MnAs nanoclusters

    SciTech Connect (OSTI)

    Fischer, M.; Klar, P. J.; Elm, M. T.; Sakita, S.; Hara, S.

    2015-01-19

    We report on magnetotransport measurements on a MnAs nanocluster arrangement consisting of two elongated single-domain clusters connected by a metal spacer. The arrangement was grown on GaAs(111)B-substrates by selective-area metal organic vapor phase epitaxy. Its structural properties were investigated using scanning-electron microscopy and atomic-force microscopy, while its magnetic domain structure was analyzed by magnetic-force microscopy. The magnetoresistance of the arrangement was investigated at 120 K for two measurement geometries with the magnetic field oriented in the sample plane. For both geometries, discrete jumps of the magnetoresistance of the MnAs nanocluster arrangement were observed. These jumps can be explained by magnetic-field induced switching of the relative orientation of the magnetizations of the two clusters which affects the spin-dependent scattering in the interface region between the clusters. For a magnetic field orientation parallel to the nanoclusters' elongation direction a spin-valve like behavior was observed, showing that ferromagnetic nanoclusters may be suitable building blocks for planar magnetoelectronic devices.

  15. PRECLOSURE CONSEQUENCE ANALYSES FOR LICENSE APPLICATION

    SciTech Connect (OSTI)

    S. Tsai

    2005-01-12

    Radiological consequence analyses are performed for potential releases from normal operations in surface and subsurface facilities and from Category 1 and Category 2 event sequences during the preclosure period. Surface releases from normal repository operations are primarily from radionuclides released from opening a transportation cask during dry transfer operations of spent nuclear fuel (SNF) in Dry Transfer Facility 1 (DTF 1), Dry Transfer Facility 2 (DTF 2), the Canister Handling facility (CHF), or the Fuel Handling Facility (FHF). Subsurface releases from normal repository operations are from resuspension of waste package surface contamination and neutron activation of ventilated air and silica dust from host rock in the emplacement drifts. The purpose of this calculation is to demonstrate that the preclosure performance objectives, specified in 10 CFR 63.111(a) and 10 CFR 63.111(b), have been met for the proposed design and operations in the geologic repository operations area. Preclosure performance objectives are discussed in Section 6.2.3 and are summarized in Tables 1 and 2.

  16. Effect of catalyst diameter on vapour-liquid-solid growth of GaAs nanowires

    SciTech Connect (OSTI)

    O'Dowd, B. J. Shvets, I. V.; Wojtowicz, T.; Kolkovsky, V.; Wojciechowski, T.; Zgirski, M.; Rouvimov, S.; Liu, X.; Pimpinella, R.; Dobrowolska, M.; Furdyna, J.

    2014-08-14

    GaAs nanowires were grown on (111)B GaAs substrates using the vapour-liquid-solid mechanism. The Au/Pt nanodots used to catalyse wire growth were defined lithographically and had varying diameter and separation. An in-depth statistical analysis of the resulting nanowires, which had a cone-like shape, was carried out. This revealed that there were two categories of nanowire present, with differing height and tapering angle. The bimodal nature of wire shape was found to depend critically on the diameter of the Au-Ga droplet atop the nanowire. Transmission electron microscopy analysis also revealed that the density of stacking faults in the wires varied considerably between the two categories of wire. It is believed that the cause of the distinction in terms of shape and crystal structure is related to the contact angle between the droplet and the solid-liquid interface. The dependency of droplet diameter on contact angle is likely related to line-tension, which is a correction to Young's equation for the contact angle of a droplet upon a surface. The fact that contact angle may influence resulting wire structure and shape has important implications for the planning of growth conditions and the preparation of wires for use in proposed devices.

  17. SEISMIC ANALYSIS FOR PRECLOSURE SAFETY

    SciTech Connect (OSTI)

    E.N. Lindner

    2004-12-03

    The purpose of this seismic preclosure safety analysis is to identify the potential seismically-initiated event sequences associated with preclosure operations of the repository at Yucca Mountain and assign appropriate design bases to provide assurance of achieving the performance objectives specified in the Code of Federal Regulations (CFR) 10 CFR Part 63 for radiological consequences. This seismic preclosure safety analysis is performed in support of the License Application for the Yucca Mountain Project. In more detail, this analysis identifies the systems, structures, and components (SSCs) that are subject to seismic design bases. This analysis assigns one of two design basis ground motion (DBGM) levels, DBGM-1 or DBGM-2, to SSCs important to safety (ITS) that are credited in the prevention or mitigation of seismically-initiated event sequences. An application of seismic margins approach is also demonstrated for SSCs assigned to DBGM-2 by showing a high confidence of a low probability of failure at a higher ground acceleration value, termed a beyond-design basis ground motion (BDBGM) level. The objective of this analysis is to meet the performance requirements of 10 CFR 63.111(a) and 10 CFR 63.111(b) for offsite and worker doses. The results of this calculation are used as inputs to the following: (1) A classification analysis of SSCs ITS by identifying potential seismically-initiated failures (loss of safety function) that could lead to undesired consequences; (2) An assignment of either DBGM-1 or DBGM-2 to each SSC ITS credited in the prevention or mitigation of a seismically-initiated event sequence; and (3) A nuclear safety design basis report that will state the seismic design requirements that are credited in this analysis. The present analysis reflects the design information available as of October 2004 and is considered preliminary. The evolving design of the repository will be re-evaluated periodically to ensure that seismic hazards are properly evaluated and identified. This document supersedes the seismic classifications, assignments, and computations in ''Seismic Analysis for Preclosure Safety'' (BSC 2004a).