National Library of Energy BETA

Sample records for 111b 111b 111b

  1. VEGF111b, a new member of VEGFxxxb isoforms and induced by mitomycin C, inhibits angiogenesis

    SciTech Connect (OSTI)

    Gu, Fang; Li, Xiuli; Kong, Jian; Pan, Bing; Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides of Health Ministry, Beijing ; Sun, Min; Zheng, Lemin; Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides of Health Ministry, Beijing ; Yao, Yuanqing

    2013-11-08

    Highlights: •We discovered a new member of VEGFxxxb family-VEGF111b. •We found VEGF111b mRNA and protein can be induced by mitomycin C. •We confirmed VEGF111b over-expression inhibits angiogenesis. •VEGF111b inhibits angiogenesis through inhibiting VEGF-R2/PI3K/Akt and VEGF-R2/ERK1/2 phosphorylation. -- Abstract: Vascular endothelial growth factor (VEGF-A) stimulating angiogenesis is required for tumor growth and progression. The conventional VEGF-A isoforms have been considered as pro-angiogenic factors. Another family of VEGF-A isoforms generated by alternative splicing, termed VEGFxxxb isoforms, has anti-angiogenic property, exemplified by VEGF165b. Here, we identify a new number of VEGFxxx family-VEGF111b induced by mitomycin C, although not detected in mitomycin C-unexposed ovarian cancer cells. SKOV3 cells were transfected with pcDNA{sub 3.1} empty vector, pcDNA{sub 3.1}-VEGF111b or pcDNA{sub 3.1}-VEGF165b to collect conditioned mediums respectively. VEGF111b overexpression inhibits proliferation, migration and tube formation of endothelial cell by inhibiting VEGF-R2 phosphorylation and its downstream signaling, similar to VEGF165b but slightly lower than VEGF165b. The anti-angiogenic property depends on the six amino acids of exon 8b of the VEGFxxxb isoforms. Our results show that VEGF111b is a novel potent anti-angiogenic agent that can target the VEGF-R2 and its signaling pathway to inhibit ovarian tumor growth.

  2. FIVE NEW TRANSIT EPOCHS OF THE EXOPLANET OGLE-TR-111b

    SciTech Connect (OSTI)

    Hoyer, S.; Rojo, P.; Lopez-Morales, M.; DIaz, R. F.; Chambers, J.; Minniti, D. E-mail: pato@das.uchile.cl E-mail: diaz@iap.fr E-mail: dante@astro.puc.cl

    2011-05-20

    We report five new transit epochs of the extrasolar planet OGLE-TR-111b, observed in the v-HIGH and Bessell I bands with the FORS1 and FORS2 at the ESO Very Large Telescope between 2008 April and May. The new transits have been combined with all previously published transit data for this planet to provide a new transit timing variations (TTVs) analysis of its orbit. We find no TTVs with amplitudes larger than 1.5 minutes over a four-year observation time baseline, in agreement with the recent result by Adams et al. Dynamical simulations fully exclude the presence of additional planets in the system with masses greater than 1.3, 0.4, and 0.5 M{sub +} at the 3:2, 1:2, and 2:1 resonances, respectively. We also place an upper limit of about 30 M{sub +} on the mass of potential second planets in the region between the 3:2 and 1:2 mean-motion resonances.

  3. EPA Regulation Compliance | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Mercury and Air Toxics Standards for Electric Generation Units - MATS Cross State Air Pollution Rule - CSAPR Carbon Pollution Standards for New Power Plants - 111(b) Carbon ...

  4. Summary of AEO2016 Electricity Working Group Meeting held on...

    U.S. Energy Information Administration (EIA) Indexed Site

    ... Cara EIA Napolitano, Sam EIA Slater-Thompson, Nancy EIA Hagen, Ronald DOE, Office of ... to model 111(b)-compliant technologies (e.g., IGCC co-fired with natural gas, pulverized ...

  5. CX-003623: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Routine Grounds and Maintenance ActivitiesCX(s) Applied: B1.3, B1.11, B1.15Date: 08/24/2010Location(s): IllinoisOffice(s): Science, Argonne Site Office

  6. CX-004254: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Seven Mile ProjectCX(s) Applied: B1.11, B4.6, B4.11Date: 10/07/2010Location(s): Linn County, OregonOffice(s): Bonneville Power Administration

  7. CX-008009: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Safety and Security Component Installation and Alteration CX(s) Applied: B1.11, B2.2 Date: 11/28/2011 Location(s): Washington Offices(s): Science, Pacific Northwest Site Office

  8. CX-010774: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Iona Relay Station Maintenance CX(s) Applied: B1.3, B1.11, B2.5 Date: 07/25/2013 Location(s): Idaho Offices(s): Nuclear Energy

  9. CX-004731: Categorical Exclusion Determination

    Office of Energy Efficiency and Renewable Energy (EERE)

    858 Limited Area ExpansionCX(s) Applied: B1.11, B1.13Date: 11/01/2010Location(s): New MexicoOffice(s): Sandia Site Office

  10. file://L:\\DOE-hanford.gov\\public\\boards\\hab\\advice\\advice60.htm

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    111-B Decontamination Station, the 115-B Gas Line PressureVacuum Seal House, the 118-C-4 (105-C) Horizontal Control Rod Cave and the 119-B Exhaust Air Sampler Building. The EE...

  11. CX-000567: Categorical Exclusion Determination

    Office of Energy Efficiency and Renewable Energy (EERE)

    East Avenue East End ImprovementCX(s) Applied: B1.11, B1.13Date: 12/10/2009Location(s): Livermore, CaliforniaOffice(s): Sandia Site Office

  12. The generation fleet in MISO is being affected by time, fuel...

    Broader source: Energy.gov (indexed) [DOE]

    MATS CSAPR & CWIS Clean Power Plan 111(b) & (d) Nature of Regulation Mercury and Air Toxics Standards Cross State Air Pollution Rule and Cooling Water Regulations (316(b)) New air ...

  13. DOE Technical Assistance on Greenhouse Gas Reduction Strategies...

    Broader source: Energy.gov (indexed) [DOE]

    Agency's (EPA) proposed carbon pollution standards, including the Clean Power Plan, visit EPA.gov. The proposed standards fall under Clean Air Act 111(b) and 111(d). For more ...

  14. CX-006595: Categorical Exclusion Determination

    Office of Energy Efficiency and Renewable Energy (EERE)

    Routine Monitoring and Maintenance, Sherwood, Washington, Disposal SiteCX(s) Applied: B1.3, B1.11, B3.1Date: 08/29/2011Location(s): Sherwood, WashingtonOffice(s): Legacy Management

  15. CX-011219: Categorical Exclusion Determination

    Office of Energy Efficiency and Renewable Energy (EERE)

    Office of Secure Transportation Multiple Actions CX(s) Applied: B1.2, B1.3, B1.11, B1.15 Date: 09/25/2013 Location(s): Tennessee Offices(s): Oak Ridge Office

  16. CX-007519: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Waste Management Construction Support CX(s) Applied: B1.3, B1.11, B1.23, B1.24, B1.27, B1.28, B1.29, B1.31, B2.1 Date: 12/15/2011 Location(s): Tennessee Offices(s): Y-12 Site Office

  17. CX-005682: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Routine Monitoring, Maintenance, Research, General Site, and Administrative Actions at the Shiprock, New Mexico, Disposal SiteCX(s) Applied: A1, A8, B1.3, B1.11, B1.20, B3.1Date: 04/14/2011Location(s): Shiprock, New MexicoOffice(s): Legacy Management

  18. CX-005886: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Routine Monitoring, Maintenance, General Site Actions, and Non-Routine Actions at the Edgemont, South Dakota Disposal SiteCX(s) Applied: B1.3, B1.11, B1.24Date: 05/17/2011Location(s): Edgemont, South DakotaOffice(s): Legacy Management

  19. CX-000568: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Neutron imaging of metal hydride beds at Oak Ridge National Laboratory, Spallation Neutron SourceCX(s) Applied: B1.11, B1.13, B3.6Date: 12/30/2009Location(s): TennesseeOffice(s): Sandia Site Office

  20. CX-007443: Categorical Exclusion Determination

    Office of Energy Efficiency and Renewable Energy (EERE)

    Routine Site Activities at the Shirley Basin South, Wyoming, Disposal Site CX(s) Applied: B1.3, B1.11, B1.20, B3.1 Date: 12/13/2011 Location(s): Wyoming Offices(s): Legacy Management

  1. CX-008816: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Renovations and Maintenance Activities for Buildings, Structures, Infrastructures and Equipment CX(s) Applied: B1.3, 61.4, 61.5, B1.11, B1.15, B1.16, B1.17, 81.22, B1.27, 62.1, B2.2, B2.3, 62.5 Date: 06/08/2012 Location(s): Illinois Offices(s): New Brunswick Laboratory

  2. CX-006222: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Non Comprehensive Environmental Response, Compensation, and Liability Act Permit Related, General Site Actions, and Non-Routine Actions at the Rocky Flats Site, Colorado, LM 18 - 11CX(s) Applied: B1.3, B1.11, B1.12, B1.24, B3.3Date: 06/24/2011Location(s): Jefferson County, ColoradoOffice(s): Legacy Management

  3. CX-009806: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    C-CA-CAM Building Complex Demolition and Site Restoration CX(s) Applied: B1.11, B1.16, B1.17, B1.23, B1.24, B1.27, B1.30, B1.33, B1.34 Date: 01/09/2013 Location(s): Pennsylvania Offices(s): Naval Nuclear Propulsion Program

  4. LM 03-15 | Department of Energy

    Office of Environmental Management (EM)

    3-15 LM 03-15 NEPA ID: LM 03-15 Short Title: Maintenance and Related Activities at the Burris Park, California, Site, LM 03-15 Determination: B1.3, B1.11, B1.24, B3.1, B6.1 PDF icon LM 03-15 More Documents & Publications CX-010533: Categorical Exclusion Determination CX-012726: Categorical Exclusion Determination CX-012199: Categorical Exclusion Determination

  5. LM 07-15 | Department of Energy

    Office of Environmental Management (EM)

    07-15 LM 07-15 NEPA ID: LM 07-15 Short Title: Operations, Maintenance, Repairs, Modifications, and Ongoing CERCLA Remedy-Related Actions and Site Facility Support Activities for the Monticello, Utah, Sites Determination: B1.3; B1.11; B1.24; B1.26; B1.33; B2.5; B3.1; B6.1 PDF icon LM 07-15 More Documents & Publications LM 06-15

  6. CX-011234: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Construction and Maintenance Activities at Existing Field Offices and Operation Centers CX(s) Applied: B1.3, B1.4, B1.11, B1.16, B1.17, B1.27, B1.31, B1.33, B1.34, B2.2, B2.3, B2.5, B4.7, B5.1, B5.16, B5.17, B5.23 Date: 10/17/2013 Location(s): CX: none Offices(s): Western Area Power Administration-Rocky Mountain Region

  7. Word Pro - S11

    Gasoline and Diesel Fuel Update (EIA)

    67 Table 11.1b World Crude Oil Production: Persian Gulf Nations, Non-OPEC, and World (Thousand Barrels per Day) Persian Gulf Nations b Selected Non-OPEC a Producers Total Non- OPEC a World Canada China Egypt Mexico Norway Former U.S.S.R. Russia United Kingdom United States 1973 Average .................... 20,668 1,798 1,090 165 465 32 8,324 NA 2 9,208 26,018 55,679 1975 Average .................... 18,934 1,430 1,490 235 705 189 9,523 NA 12 8,375 27,039 52,828 1980 Average ....................

  8. CX-000787: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Generic Categorical Exclusion for Site-Wide Miscellaneous Installation and Maintenance ActivitiesCX(s) Applied: B1.3, B1.4, B1.5, B1.9, B1.11, B1.15, B1.16, B1.17, B1.22, B1.27, B1.31, B2.1, B2.2, B2.3, B2.5Date: 02/08/2010Location(s): IllinoisOffice(s): Science, Argonne Site Office

  9. Categorical Exclusion Determinations: B1.8 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    8 Categorical Exclusion Determinations: B1.8 Existing Regulations B1.8: Screened water intake and outflow structures Modifications to screened water intake and outflow structures such that intake velocities and volumes and water effluent quality and volumes are consistent with existing permit limits. DOCUMENTS AVAILABLE FOR DOWNLOAD January 26, 2014 CX-011847: Categorical Exclusion Determination Routine Maintenance Activities CX(s) Applied: B1.3, B1.4, B1.5, B1.6, B1.7, B1.8, B1.11, B1.13,

  10. CX-011847: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Routine Maintenance Activities CX(s) Applied: B1.3, B1.4, B1.5, B1.6, B1.7, B1.8, B1.11, B1.13, B1.15, B1.16, B1.17, B1.21, B1.22, B1.23, B1.27, B1.28, B1.31, B1.32, B2.1, B2.2, B2.3, B2.5 Date: 01/26/2014 Location(s): New Jersey Offices(s): Princeton Site Office

  11. Structure and electrical characterization of gallium arsenide nanowires with different V/III ratio growth parameters

    SciTech Connect (OSTI)

    Muhammad, R.; Ahamad, R.; Ibrahim, Z.; Othaman, Z.

    2014-03-05

    Gallium arsenide (GaAs) nanowires were grown vertically on GaAs(111)B substrate by gold-assisted using metal-organic chemical vapour deposition. Field-emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM) and conductivity atomic force microscopy (CAFM) analysis were carried out to investigate the effects of V/III ratio on structural properties and current-voltage changes in the wires. Results show that GaAs NWs grow preferably in the wurtzite crystal structure than zinc blende crystal structure with increasing V/III ratio. Additionally, CAFM studies have revealed that zincblende nanowires indicate ohmic characteristic compared to oscillation current occurred for wurtzite structures. The GaAs NWs with high quality structures are needed in solar cells technology for trapping energy that directly converts of sunlight into electricity with maximum capacity.

  12. PRECLOSURE CONSEQUENCE ANALYSES FOR LICENSE APPLICATION

    SciTech Connect (OSTI)

    S. Tsai

    2005-01-12

    Radiological consequence analyses are performed for potential releases from normal operations in surface and subsurface facilities and from Category 1 and Category 2 event sequences during the preclosure period. Surface releases from normal repository operations are primarily from radionuclides released from opening a transportation cask during dry transfer operations of spent nuclear fuel (SNF) in Dry Transfer Facility 1 (DTF 1), Dry Transfer Facility 2 (DTF 2), the Canister Handling facility (CHF), or the Fuel Handling Facility (FHF). Subsurface releases from normal repository operations are from resuspension of waste package surface contamination and neutron activation of ventilated air and silica dust from host rock in the emplacement drifts. The purpose of this calculation is to demonstrate that the preclosure performance objectives, specified in 10 CFR 63.111(a) and 10 CFR 63.111(b), have been met for the proposed design and operations in the geologic repository operations area. Preclosure performance objectives are discussed in Section 6.2.3 and are summarized in Tables 1 and 2.

  13. SEISMIC ANALYSIS FOR PRECLOSURE SAFETY

    SciTech Connect (OSTI)

    E.N. Lindner

    2004-12-03

    The purpose of this seismic preclosure safety analysis is to identify the potential seismically-initiated event sequences associated with preclosure operations of the repository at Yucca Mountain and assign appropriate design bases to provide assurance of achieving the performance objectives specified in the Code of Federal Regulations (CFR) 10 CFR Part 63 for radiological consequences. This seismic preclosure safety analysis is performed in support of the License Application for the Yucca Mountain Project. In more detail, this analysis identifies the systems, structures, and components (SSCs) that are subject to seismic design bases. This analysis assigns one of two design basis ground motion (DBGM) levels, DBGM-1 or DBGM-2, to SSCs important to safety (ITS) that are credited in the prevention or mitigation of seismically-initiated event sequences. An application of seismic margins approach is also demonstrated for SSCs assigned to DBGM-2 by showing a high confidence of a low probability of failure at a higher ground acceleration value, termed a beyond-design basis ground motion (BDBGM) level. The objective of this analysis is to meet the performance requirements of 10 CFR 63.111(a) and 10 CFR 63.111(b) for offsite and worker doses. The results of this calculation are used as inputs to the following: (1) A classification analysis of SSCs ITS by identifying potential seismically-initiated failures (loss of safety function) that could lead to undesired consequences; (2) An assignment of either DBGM-1 or DBGM-2 to each SSC ITS credited in the prevention or mitigation of a seismically-initiated event sequence; and (3) A nuclear safety design basis report that will state the seismic design requirements that are credited in this analysis. The present analysis reflects the design information available as of October 2004 and is considered preliminary. The evolving design of the repository will be re-evaluated periodically to ensure that seismic hazards are properly evaluated and identified. This document supersedes the seismic classifications, assignments, and computations in ''Seismic Analysis for Preclosure Safety'' (BSC 2004a).