In its "Trailblazers of North American Research" edition, International Innovation explores a spectrum of groundbreaking research and development activities, including those at the nation's largest supporter of basic research in the physical sciences – the U.S. Department of Energy (DOE) Office of Science. In an exclusive interview, Office of Science Director William F. Brinkman offers insights on achieving greater energy security, maintaining the balance between applied and discovery-based research, and the importance of communication among scientific communities. Dr. Brinkman provides a glimpse into the Department's initiatives in particle physics, bioenergy, and more. When asked about the "societal benefits" of the Office of Science work, he quotes Vannevar Bush, in effect the nation's first science advisor, on the importance of science to U.S. prosperity, and states, "As a mainstay of federal science funding, we have been a major contributor to underwriting the prosperity and security of the nation over the past 60 years. Examples include superconducting magnet technology, radioisotopes, battery materials, semiconductor processing, and many others."