Springer, Timothy A. - Immune Disease Institute & Department of Pathology, Harvard University

• Molecular Cell The Structure of a Receptor with Two
• Molecular Cell Short Article
• Immunity, Vol. 20, 393406, April, 2004, Copyright 2004 by Cell Press Rolling Adhesion through an Extended
• Structural and Functional Studies with Antibodies to the Integrin A MODEL FOR THE I-LIKE DOMAIN*
• DOI: 10.1126/science.1170905 , 1330 (2009);324Science
• Structural basis for selectin mechanochemistry Timothy A. Springer1
• Engineering of Single Ig Superfamily Domain of Intercellular Adhesion Molecule 1 (ICAM-1) for Native Fold and Function*S
• A mechanically stabilized receptorligand flex-bond important in the vasculature
• Rationally Designed Integrin 3 Mutants Stabilized in the High Affinity Conformation*
• Available online at www.sciencedirect.com Trans-cellular migration: cellcell contacts get intimate
• THEJOURNALOFCELLBIOLOGY JCB: ARTICLE
• Binding between the Integrin X 2 (CD11c/CD18) and Heparin* Received for publication,July 25, 2007 Published, JBC Papers in Press,August 14, 2007, DOI 10.1074/jbc.M706114200
• Tests of the Extension and Deadbolt Models of Integrin Activation*
• COCEBI-387; NO OF PAGES 8 Integrin structures and conformational signaling
• AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation
• Structure 14, 16111616, November 2006 2006 Elsevier Ltd All rights reserved DOI 10.1016/j.str.2006.10.001 MinireviewComplement and the Multifaceted
• Regulation of outside-in signaling and affinity by the 2 I domain of integrin L 2
• A Small Molecule Agonist of an Integrin, L 2 Received for publication,July 19, 2006 Published, JBC Papers in Press,October 5, 2006, DOI 10.1074/jbc.M606888200
• Remodeling of the lectinEGF-like domain interface in P-and L-selectin increases adhesiveness and shear
• Contribution of N-Linked Glycans to the Conformation and Function of Intercellular Adhesion Molecules (ICAMs)*
• Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity,
• The Relative Influence of Metal Ion Binding Sites in the I-like Domain and the Interface with the Hybrid Domain on
• Molecular Cell, Vol. 14, 269276, April 23, 2004, Copyright 2004 by Cell Press Short ArticleStructural Basis for Dimerization
• THEJOURNALOFCELLBIOLOGY The Rockefeller University Press $8.00
• Boca-dependent maturation of b-propeller/EGF modules in low-density lipoprotein receptor
• Developmental Cell, Vol. 7, 585595, October, 2004, Copyright 2004 by Cell Press RIAM, an Ena/VASP and Profilin Ligand,
• THEJOURNALOFCELLBIOLOGY The Rockefeller University Press $8.00
• Allosteric 1 Integrin Antibodies That Stabilize the Low Affinity State by Preventing the Swing-out of the Hybrid Domain*
• Structure and allosteric regulation of the X 2 integrin I domain
• Thin-layer chromatography TLC was done on silica gel plates as previously described17
• R E V I E W S NATURE REVIEWS | DRUG DISCOVERY VOLUME 2 | SEPTEMBER 2003 | 703
• Endothelial Cells Proactively Form Microvilli-Like Membrane Projections upon Intercellular Adhesion Molecule 1
• Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases
• Transition From Rolling to Firm Adhesion Is Regulated by the Conformation of the I Domain of the Integrin Lymphocyte
• www.sciencemag.org SCIENCE VOL 296 17 MAY 2002 1253 CREDIT:BETTMANN/CORBIS
• Integrins and other cell surface receptors have been fertile grounds for structure prediction experiments. Recently
• Annu. Rev. Biophys. Biomol. Struct. 2002. 31:485516 DOI: 10.1146/annurev.biophys.31.101101.140922
• Junichi Takagi Integrin activation and structural Timothy A. Springer
• Amino Acid Residues in the PSI Domain and Cysteine-rich Repeats of the Integrin 2 Subunit That Restrain
• Amino Acid Residues in the IIb Subunit That Are Critical for Ligand Binding to Integrin IIb 3 Are Clustered in the
• Selectin receptorligand bonds: Formation limited by shear rate and dissociation governed by the
• Association of the Membrane Proximal Regions of the and Subunit Cytoplasmic Domains Constrains an Integrin in the
• IL-8 Production in Human Lung Fibroblasts and Epithelial Cells Activated by the Pseudomonas Autoinducer
• Expression of Stromal-Derived Factor-1 Is Decreased by IL-1 and TNF and in Dermal Wound Healing1
• Dimerization and the effectiveness of ICAM-1 in mediating LFA-1-dependent adhesion
• Folding and Function of I Domain-deleted Mac-1 and Lymphocyte Function-associated Antigen-1*
• Proc. Natl. Acad. Sci. USA Vol. 96, pp. 30173022, March 1999
• The Rockefeller University Press, 0021-9525/99/01/185/16 $2.00 The Journal of Cell Biology, Volume 144, Number 1, January 11, 1999 185200
• Proc. Natl. Acad. Sci. USA Vol. 96, pp. 22152220, March 1999
• JOURNAL OF VIROLOGY, 0022-538X/98/$04.00 0
• Differential Requirements for LFA-1 Binding to ICAM-1 and LFA-1-Mediated Cell Aggregation1
• 0014-2980/98/0101-104$17.50+.50/0 WILEY-VCH Verlag GmbH, D-69451 Weinheim, 1998 Transendothelial chemotaxis of human > / I and q / p
• JOURNAL OF VIROLOGY, 0022-538X/98/$04.00 0
• The Rockefeller University Press, 0021-9525/98/02/721/11 $2.00 The Journal of Cell Biology, Volume 140, Number 3, February 9, 1998 721731
• Nature Macmillan Publishers Ltd 1998 letters to nature
• Contrasting Responses to Multiple Chemotactic Stimuli in Transendothelial Migration
• Molecular Biology of the Cell Vol. 8, 26472657, December 1997
• Proc. Natl. Acad. Sci. USA Vol. 94, pp. 19251930, March 1997
• Neutrophil Interactions with Adherent Platelets 2085 J. Clin. Invest.
• Role of a,& lntegrin Avidity in Transendothelial Chemotaxis of Mononuclear Cells`
• The a Subunit Cytoplasmic Domain Regulates the Assembly and Adhesiveness of lntegrin Lymphocyte Function-Associated
• The Rockefeller University Press, 0021-9525/97/09/1169/12 $2.00 The Journal of Cell Biology, Volume 138, Number 5, September 8, 1997 11691180
• 111 J. Exp. Med. The Rockefeller University Press 0022-1007/97/01/111/10 $2.00 Volume 185, Number 1, January 6, 1997 111120
• Proc. Natl. Acad. Sci. USA Vol. 94, pp. 6572, January 1997
• A Schiff Base with Mildly Oxidized Carbohydrate Ligands Stabilizes L-selectin and not P-selectin or E-selectin
• Modulation of Endothelial Cell Adhesion by Hevin, an Acidic Protein Associated with High Endothelial Venules*
• Immunity, Vol. 4, 179187, February, 1996, Copyright 1996 by Cell Press The CC Chemokine MCP-1 Differentially
• A Differential Role for Cell Shape in Neutrophil Tethering and Rolling on Endothelial Selectins Under Flow'
• Sequential Regulation of ct4131and ct5131Integrin Avidity by CC Chemokines in Monocytes
• Neutrophil Rolling, Arrest, and Transmigration Across Activated, Surface-Adherent Platelets Via Sequential Action of P-Selectin and the &-Integrin
• Role of ICAM-1 in Stroke 209 J. Clin. Invest.
• INFECTION AND IMMUNITY, July 1996, p. 28042807 Vol. 64, No. 7 0019-9567/96/$04.00 0
• Glycolipid LigandsForSelectinsSupport Leukocyte Tethering and Rolling Under Physiologic Flow Conditions'
• Heparin Is an Adhesive Ligand for the Leukocyte Integrin Mac-1 (CDllb/CD18)
• Annu.Rev.Physiol.1995.57:827-72 Copyright1995byAnnualReviewsInc.Allrightsreserved
• CD ANTIGENS 1993 S. F. Schlossman, L. Boumsell, W. Cilks, J.M. Harlan, 1.Kishimoto, C. Morimoto, J.Ritz,
• Residues Within a Conserved Amino Acid Motif of Domains 1 and 4 of VCAM-1 Are Required for Binding to VLA-4
• Eur. J. Immunol. 1979. 9: 301-306 Phagocyte-specificmonoclonal antibody 301 8 Gershon, R. K., Maurer, P. H. and Merryman, C. F., Proc. Nar.
• Activation of integrin -subunit I-like domains by one-turn C-terminal -helix deletions
• Structure, Vol. 10, 14531464, October, 2002, 2002 Elsevier Science Ltd. All rights reserved. PII S0969-2126(02)00840-7 Archaeal Surface Layer Proteins Contain
• The integrin -subunit leg extends at a -dependent epitope in the thigh genu
• Molecular Biology of the Cell Vol. 14, 25702582, June 2003
• The Novel S527F Mutation in the Integrin 3 Chain Induces a High Affinity IIb 3 Receptor by Hindering Adoption of the
• Identification and characterization of a human monoclonal antagonistic antibody AL-57 that preferentially binds the high-
• Subscriber access provided by HARVARD UNIV Biochemistry is published by the American Chemical Society. 1155 Sixteenth
• Structure, Vol. 12, 21372147, December, 2004, 2004 Elsevier Ltd. All rights reserved. DOI 10.1016/j.str.2004.10.005 Conversion between Three Conformational States
• Structural basis for allostery in integrins and binding to fibrinogen-mimetic
• The Rockefeller University Press, 0021-9525/97/05/755/11 $2.00 The Journal of Cell Biology, Volume 137, Number 3, May 5, 1997 755765 755
• Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity
• The Binding Sites for Competitive Antagonistic, Allosteric Antagonistic, and Agonistic Antibodies to the I Domain of
• Cation-interaction regulates ligand-binding affinity and signaling of integrin 47
• The Faster Kinetics of 1-Selectin Than of E-Selectin and P-Selectin Rolling at Comparable Binding Strength'
• 674 nature structural biology volume 7 number 8 august 2000 Computational design of an
• RAPID COMMUNICATION Receptor Tyrosine Kinase Stimulates Cell-Matrix Adhesion by
• size; island size promoted abundances of some organisms and reduced others (Fig. 1). Second,
• Activation of Lymphocyte Function-Associated Molecule4 (CDlla/CD18) and Mac-1 (CD11b/CD18) Mimicked by an
• Molecular Basis for Interaction between Icap1 PTB Domain and 1 Integrin*
• Proc. Natl. Acad. Sci. USA Vol. 95, pp. 48704875, April 1998
• BriefDefinitive Report Cloning, Expression, and Characterization of the Human
• Overlapping and Selective Roles of Endothelial Intercellular Adhesion Molecule-1 (ICAM-1) and ICAM-2 in Lymphocyte
• Immunity, Vol. 10, 919, January, 1999, Copyright 1999 by Cell Press Prolonged Eosinophil Accumulation in Allergic
• Transmission of allostery through the lectin domain in selectin-mediated cell adhesion
• Cell, Vol. 102, 275277, August 4, 2000, Copyright 2000 by Cell Press Letter to the Editor
• Transcellular Diapedesis Is Initiated by Invasive Podosomes
• Integrin avidity regulation: are changes in affinity and conformation underemphasized?
• HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Requirement of and subunit transmembrane helix separation for integrin
• Rational Design of Intercellular Adhesion Molecule-1 (ICAM-1) Variants for Antagonizing Integrin Lymphocyte
• Activation-induced Conformational Changes in the I Domain Region of Lymphocyte Function-associated Antigen 1*
• Chondroitin sulfate B exerts its inhibitory effect on secondary lymphoid tissue chemokine (SLC) by binding
• Immunity 25, 583594, October 2006 2006 Elsevier Inc. DOI 10.1016/j.immuni.2006.07.016 Activation of Leukocyte b2 Integrins by Conversion
• Junichi Takagi1,2,3,4 , Konstantin Strokovich5
• Proc. Natl. Acad. Sci. USA Vol. 95, pp. 1163111636, September 1998
• Interactions through L-selectin between Leukocytes and Adherent Leukocytes Nucleate Rolling Adhesions
• Sialylated, Fucosylated Ligands for L-Selectin Expressed on Leukocytes Mediate Tethering and
• The Top of the Inserted-like Domain of the Integrin Lymphocyte Function-associated Antigen-1 Subunit Contacts the Subunit
• Protection from Lymphoma Cell Metastasis in ICAM-1 Mutant Mice: A Posthoming Event
• Proc. Natl. Acad. Sci. USA Vol. 93, pp. 1093910944, October 1996
• Structural Basis of Integrin Regulation and Signaling
• Proc. Natl. Acad. Sci. USA Vol. 94, pp. 31723177, April 1997
• High Affinity Ligand Binding by Integrins Does Not Involve Head Separation*
• Visualization of CD2 Interaction with LFA-3 and Determination of the Two-Dimensional Dissociation Constant for Adhesion Receptors in a
• Locking in alternate conformations of the integrin L 2 I domain with disulfide bonds reveals
• Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein
• Cardiac Graft Intercellular Adhesion Molecule-1 (ICAM-1) and Interleukin-1 Expression Mediate Primary Isograft
• Journal of Immunological Methods, 37 (1980) 139--152 139 Elsevier/North-Holland Biomedical Press
• Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules
• The Structure of the -Propeller Domain and C-terminal Region of the Integrin M Subunit
• The Integrin VLA-4 Supports Tethering and Rolling in Flow on VCAM-1 Ronen Alon,* Paul D. Kassner,* Michelle Woldemar Carr,*Erik B. Finger,* Martin E. Hemler,*
• The connection between metal ion affinity and ligand affinity in integrin I domains
• Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring
• Proc. Natl. Acad. Sci. USA Vol. 95, pp. 94489453, August 1998
• 0014-2980/98/0303-961$17.50+.50/0 WILEY-VCH Verlag GmbH, D-69451 Weinheim, 1998 The chemokine receptor CXCR3 mediates rapid
• Proc. Natl. Acad. Sci. USA Vol. 95, pp. 41344139, April 1998
• Transition from Rolling to Firm Adhesion Can Be Mimicked by Extension of Integrin L 2 in an Intermediate Affinity State*
• CURRICULUM VITAE Timothy Alan Springer
• CD44 and Hyaluronan-dependent Rolling Interactions of Lymphocytes on Tonsillar Stroma
• Steel Factorand c-kit Regulate Cell-Matrix Adhesion By Tatsuo Kinashi and Timothy A. Springer
• Structural plasticity in Ig superfamily domain 4 of ICAM-1 mediates cell surface dimerization
• Proc. Nat. Acad. Sci. USA Vol. 71, No. 4, pp. 1539-1543, April 1974
• doi:10.1182/blood-2010-04-281154 Prepublished online Aug 2, 2010;
• Localization of the Binding Site on Intercellular Adhesion Molecule-3 (ICAM-3) for Lymphocyte Function-associated
• Epitope Mapping of Antibodies to the C-Terminal Region of the Integrin 2 Subunit Reveals Regions that Become Exposed
• Integrin 3 regions controlling binding of murine mAb 7E3: Implications for the mechanism of integrin
• Molecular Cell Structure of a Complete Integrin Ectodomain
• 753 J. Exp. Med. The Rockefeller University Press 0022-1007/98/03/753/10 $2.00 Volume 187, Number 5, March 2, 1998 753762
• A Specific Interface between Integrin Transmembrane Helices
• The leukocyte lntegrin pl50,95 (CD11c/CD18) as a Receptor for iC3b
• Immunity, Vol. 2, 113-123, January, 1995, Copyright 0 1995 by Cell Press Cloning from Purified High Endothelial Venule Cells
• Interactions of Human ~/~3 and ~//8 T Lymphocyte Subsets in Shear Flow with E-Selectin and P-Selectin
• Proc. Natl. Acad. Sci. USA Vol. 94, pp. 31563161, April 1997
• Structural transitions of complement component C3 and its activation products
• Immunity, Vol. 10, 463471, April, 1999, Copyright 1999 by Cell Press The Chemokine Receptor CXCR4 Is Required for
• Highendothelialvenules(HEVs):specialized endotheliumfor lymphocytemigration
• A Highly Efficacious Lymphocyte Chemoattractant, Stromal Cell-derived Factor 1 (SDF-1)
• THE SMALL SUBUNIT OF HL-A ANTIGENS IS ~2-MICROGLOBULIN*
• Modulation of Integrin Activation by an Entropic Spring in Received for publication,May 14, 2010, and in revised form, July 20, 2010 Published, JBC Papers in Press,July 28, 2010, DOI 10.1074/jbc.M110.145177
• Sialomucin CD34 Is the Major L-Selectin Ligand in Human Tonsil High Endothelial Venules
• Interaction of Very Late Antigen-4 with VCAM-1 Supports Transendothelial Chemotaxis of Monocytes by Facilitating
• Kinetic and Mechanical Basis of Rolling through an Integrin and Novel -Dependent Rolling and Mg2+
• High Avidity State of Leukocyte Function-Associated Antigen-1onRheumatoidSynovialFluid T Lymphocytes'
• The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin
• TheJournalofExperimentalMedicine The Journal of Experimental Medicine
• Characterization of Murine Intercellular Adhesion Molecule-2' Hong Xu,'* JoannaK. Bickford,' Ed Luther,* Carmine Carpenito, Fumio Takei, and
• JOURNAL OF VIROLOGY, 0022-538X/01/$04.00 0 DOI: 10.1128/JVI.75.2.10771082.2001
• Letters to the Editor Measurement of Selectin Tether Bond Lifetimes
• Two-dimensional Kinetics Regulation of L 2-ICAM-1 Interaction by Conformational Changes of the
• Reversibly locking a protein fold in an active conformation with a disulfide bond: Integrin
• MOLECULAR AND CELLULAR BIOLOGY, Nov. 2010, p. 54325443 Vol. 30, No. 22 0270-7306/10/$12.00 doi:10.1128/MCB.00742-10
• Current Topics in Medicinal Chemistry 2004, 4, 1485-1495 1485 1568-0266/04 $45.00+.00 2004 Bentham Science Publishers Ltd.
• Specific and covalent labeling of a membrane protein with organic fluorochromes and quantum dots
• Importance of Force Linkage in Mechanochemistry of Adhesion Receptors Nathan S. Astrof, Azucena Salas, Motomu Shimaoka, JianFeng Chen, and Timothy A. Springer*
• Proc. Nat. Acad. Sci. USA Vol. 71, No. 5, pp. 2123-2127, May 1974
• Functional Expression of the CXC-Chemokine Receptor-4/ Fusin on Mouse Microglial Cells and Astrocytes'
• Immunity, Vol. 16, 205218, February, 2002, Copyright 2002 by Cell Press Role for CCR7 Ligands in the Emigration
• Eosinophil Arrest in Shear Flow 2017 J. Clin. Invest.
• Cell, Vol. 110, 599611, September 6, 2002, Copyright 2002 by Cell Press Global Conformational Rearrangements
• Locking the 3 Integrin I-like Domain into High and Low Affinity Conformations with Disulfides*
• Proc. Natl. Acad. Sci. USA Vol. 94, pp. 31623167, April 1997
• Immunity, Vol. 19, 391402, September, 2003, Copyright 2003 by Cell Press Small Molecule Integrin Antagonists that Bind to
• Characterization of Lymphocyte Function-Associated Antigen 1 (LFA-1)-Deficient T Cell Lines
• Cell, Vol. 112, 99111, January 10, 2003, Copyright 2003 by Cell Press Structures of the L I Domain and Its Complex
• Stabilizing the integrin M inserted domain in alternative conformations with a range of
• 1056 Kelly, Williams, Colvin, Meehan, Springer, Gutirrez-Ramos, and Bonventre J. Clin. Invest.
• Distinct Cell Surface Ligands Mediate T Lymphocyte Attachment and Rolling on P and
• An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3
• Structure of an integrin with an aI domain, complement receptor type 4
• Proc. Natl. Acad. Sci. USA Vol. 93, pp. 1472614729, December 1996
• An Extracellular bbb-Propeller Module Predicted in Lipoprotein and Scavenger Receptors, Tyrosine
• A high affinity human antibody antagonist of P-selectin mediated rolling Jeffrey S. Swers a
• Communication Vol. 258, No.5. h u e of March IO, pp. 276627659, 19HR T H E JOURNALOF BIOLOGICALCHEMISTRY
• THE Joun~.,~ OF BIOLOGICAL CHEMISTRY Vol. 252, No. 13, Issue of July 10, pp. 4682-4693, 1977
• 0022-1767/92/1489-2654$02.00/0 Copyright ( 0 1992 by The American Association of Immunologists
• THEJOURNAL OF BIOLOGICALCHEMISTRY Vol. 256, No. 8,Issue of April 25, pp. 3833-3839, 1981
• 2011NatureAmerica,Inc.Allrightsreserved. nature structural & molecular biology advance online publication
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• Influence ofReceptor Lateral Mobility on Adhesion Strengthening between Membranes Containing LFA3 and CD2
• 0022-1767/82/1283-1221$02.00/0 THE JOURNAL OF IMMUNOLOGY
• Association of Intercellular Adhesion Moleculeq (ICAM-1) with Actin-containing Cytoskeleton and -actinin
• 0022-1767/81/1261-035@$02.00/0 THE JOURNAL OF IMMUNOLOGY
• Leishmania Promastigotes Require Opsonic Complement to Bind to the Human Leukocyte Integrin Mac-1(CD11b/CD18)
• Lymphocyte Adhesion through Very Late Antigen 4: Evidence for a Novel Binding Site in the
• THE JOURNAL OF BIOLOGICAL CHEMWP~Y Vol. 252, No. 13, Issue of July 10, pp. 4694-4700, 1977
• The I Domain Is a Major Recognition Site on the Leukocyte Integrin Mac-1 (CDllb/CD18) for Four Distinct Adhesion Ligands
• 0022-1767/92/1498-2650$02.00/0 CopyrightQ 1992 by The American Association of Immunologists
• ICAM-1(CD54): A Counter-Receptor for Mac-1(CDllb/CD18) Michael S. Diamond,* Donald E. Staunton, Antonin R. de Fougerolles,S Steven A. Stacker,
• 0022-1767/86/1374-1270$02.00/0 Copyright01986 by The AmericanAssociationof Immunologists
• 0022-1767/85/1345-3286$02.00/0 Copyright0 1985by The American Association of Immunologists
• The Cytoplasmic Domain of the Integrin Lymphocyte Function-associated Antigen 1/3 Subunit: Sites
• A pH-regulated dimeric bouquet in the structure of von Willebrand factor
• Intercellular Adhesion Molecule 3, a Third Adhesion Counter-Receptor for Lymphocyte Function-associated
• 0022-1767/91/1462-0648$02.00/0 THEJOURNAL OF IMMUNOLOGY
• TIBS 24 JULY 1999 Domains in plexins: links
• 00Z2-1767/85/1345-3019S02.00/0 THEJOURNALOF IMMUNOLOGY Vol. 134. No. 5. May 1985
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• ARTICLE doi:10.1038/nature10152 Latent TGF-b structure and activation
• 0022-1767/83/1301-0309$02.00/0 THE JOURNAL OF IMMUNOLOGY
• Characterization of the Function of Intercellular Adhesion Molecule (ICAM)-3 and Comparison with
• ANTI-Mac-1 SELECTIVELY INHIBITS THE MOUSE AND HUMAN TYPE THREE COMPLEMENT RECEPTOR*
• 0022-1767/85/1351-0147$02,00/0 Copyright0 1985 by The American Association of Immunologlsts
• 0022-1767/84/1326-301I$OZ.OO/O THEJOURNAL OF IUMUNOLGGY
• Micromanipulation ofAdhesion of a Jurkat Cell to a Planar Bilayer Membrane Containing Lymphocyte Function-associated
• Br/es Detlnitive Report Cloning and Expression of Intercellular Adhesion
• THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 265, No. 5, Issue of February 15, pp. 2782%2766,199O 0 1990 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in U.S. A.
• 0022-1767/82/1283-1409%00.00/0 THE JOURNAL OF lMMUNOLOGY
• P-Selectin,L-Selectin,and a4lntegrin Have Distinct Roles in Eosinophil Tethering and Arrest on Vascular Endothelial Cells
• INTACT IIb3 EXTENDS AFTER ACTIVATION MEASURED BY SOLUTION X-RAY SCATTERING AND ELECTRON MICROSCOPY
• 0022-1767/85/1354-2668$02.00/0 THEJOURNALOF h " N 0 L o C Y
• Requirement of open headpiece conformation for activation of leukocyte integrin X2
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• Motility and Ultrastructure ofLarge Granular Lymphocytes on Lipid Bilayers Reconstituted with
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• Leukocytosis and Resistance to Septic Shock in Intercellular Adhesion Molecule 1-deficient Mice
• 0022-1767/90/1454-1181$02.00/0 THEJOURNALOF IMMUNOLCGY
• Characterization of ICAM-2 and Evidence for a Third Counter-Receptor for LFA1
• 0022-1767/81 / I 276-2488$02.00/0 THE JOURNALOF IMMUNOLOGY
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• 590 SLOVIN ET AL. [VOL. 127 tion and immunofluorescence. Arthritis Rheum. 19:711,
• A HUMAN LEUKOCYTE DIFFERENTIATION ANTIGEN FAMILY WITH DISTINCT a-SUBUNITS AND A COMMON 3-
• MAPPING OF ANTIGENIC AND FUNCTIONAL EPITOPES ON THE a-AND/3-SUBUNITS OF TWO RELATED MOUSE
• OOZZ-1767/9l/147l-O36SO~.OO/O Copyright C 1991 by The American Assoclatlon of Immunologists
• 1981J STAPHPROTEIN A BINDING HUMAN y3 MYELOMAPROTEIN 923 43. Natvig. J. 8..and H. G. Kunkel. 1974. A hybrid lgG4-lgG2 immunoglobulin.
• 0022-1767/83/1313-1182$02.00/0 THEJOURNALOF lMMUNOLOGY
• Vol. 257. No. 20, Issue of October 25, pp. 12412-12418, 1982 Printed in U.S.A.
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• Annu.Rev.CellBiol. 1990.6 ." 359~402 Copyright1990by AnnualReviewsInc. All rights reserved
• Distinct Mutations in Two Patients with Leukocyte Adhesion Deficiency and Their Functional Correlates
• An isolated, surface-expressed I domain of the integrin L 2 is sufficient for strong adhesive
• 0022-1767/93/15111-6338$02.00/0 The Journal of Immunology
• A Subpopulation of Mac-1 (CDllb/CD18) Molecules Mediates Neutrophil Adhesion to ICAM-1and Fibfinogen
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• 18. Lowry, 0.H.,N. J. Rosebrough, A. L. Farr. and R. J. Randall. 1951.Protein measurementwith the Folin-phenol agent. J. Biol. Chem. 193265.
• Annu.Rev. Immunol.1991.9.'27~66 Copyright1991by AnnualReviewsInc. All rights reserved
• INVITED REVIEW Biology and physics of von Willebrand factor concatamers
• 0022-1767/85/1355-3102$02.00/0 Copyright 0 1985by The American Association of Immunologists
• THE REQUIREMENT FOR LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN 1 IN HOMOTYPIC LEUKOCYTE
• Purification of HLA-linked B Lymphocyte Alloantigens in Immunologically Active Form by Preparative Sodium
• doi:10.1182/blood-2010-11-321596 Prepublished online March 8, 2011;
• BriefDefinitive Report Soluble Intercellular Adhesion Molecule 1-
• INHERITED DEFICIENCY OF THE Mac-l, LFA-1, p150,95 GLYCOPROTEIN FAMILY AND ITS MOLECULAR BASIS
• 0022-1767/83/1301-0108$02 OO/O THE JOURNALOF IMMUNOLOGY
• Regulation of integrin affinity on cell surfaces Thomas Schu rpf and Timothy A Springer*
• 984 VOLUME 18 NUMBER 9 SEPTEMBER 2011 nature structural & molecular biology a rt i c l e s
• CURRICULUM VITAE Timothy Alan Springer
• The C-Terminal I Domain Linker as a Critical Structural Element in the Conformational Activation of I Integrins*
• Integrin inside-out signaling and the immunological synapse Timothy A Springer1
• CURRICULUM VITAE Timothy Alan Springer