Higgins, Darren - Department of Microbiology and Molecular Genetics, Harvard University

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Higgins, Darren - Department of Microbiology and Molecular Genetics, Harvard University

The acquisition of cell polarity is among the earliest steps during the development of multicellular eukary-
Florian Lu ders, Hiroaki Segawa1 David Stein2
letters to nature 676 NATURE |VOL 403 |10 FEBRUARY 2000 |www.nature.com
Inhibition of ROCK activity allows InlF-mediated invasion and increased virulence of Listeria monocytogenes
476 | VOL.6 NO.7 | JULY 2009 | nature methods correspondence
Copyright 1999 by the Genetics Society of America I-SceI Endonuclease, a New Tool for Studying DNA Double-Strand Break Repair
Conserved microRNA targeting in Drosophila is as widespread in coding regions as in 3UTRs
The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family
Cell, Vol. 81, 63-71, April 7, 1995,Copyright 1995by CellPress The Torso Receptor Tyrosine Kinase
Research article 2142 TheJournalofClinicalInvestigation http://www.jci.org Volume 116 Number 8 August 2006
Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular
Molecular Cell, Vol. 2, 719727, December, 1998, Copyright 1998 by Cell Press Opposing Actions of CSW and RasGAP Modulate
Supplemental Data S1 Weckle Is a Zinc Finger Adaptor
DEVELOPMENTAL BIOLOGY 105, 404-414 (1984) The Effects of Zygotic Lethal Mutations on Female Germ-Line
Heparan sulfate proteoglycan modulation of developmental signaling in Drosophila
Developmental Cell SALS, a WH2-Domain-Containing Protein,
Molecular Cell, Vol. 4, 633639, October, 1999, Copyright 1999 by Cell Press Hedgehog Movement Is Regulated
Copyright 0 1996 hy the Genetics Society of America Zygotic Lethal Mutations With Maternal Effect Phenotypes in Drosophila
Introduction The Drosophila Notch gene encodes a member of a family of
Parallel Chemical Genetic and Genome-Wide RNAi Screens
INTRODUCTION The 14-3-3 proteins are a family of small acidic molecules that
Presenilin Affects Arm/ -Catenin Localization and Function in Drosophila
Annu. Rev. Cell Dev. Biol. 2002. 18:46393 doi: 10.1146/annurev.cellbio.18.022602.131838
RESEARCH ARTICLE Open Access False negative rates in Drosophila cell-based
Wong, and T. Yen for helpful advice and reagents. Supported by NIH grant GM35527 (W.J.N.) and by a
INTRODUCTION Formation of the Drosophila egg involves the contribution
2011NatureAmerica,Inc.Allrightsreserved. brief communications
10.1261/rna.1611309Access the most recent version at doi: published online July 27, 2009RNA
Droplet microfluidic technology for single-cell high-throughput screening
ABRF 2009 SELECTED PRESENTATIONS Use of a Label-Free Quantitative Platform Based on MS/MS Average
Cell, Vol. 96, 847856, March 19, 1999, Copyright 1999 by Cell Press The Transmembrane Molecule Kekkon 1 Acts in a
Leading Edge Cell 128, January 26, 2007 2007 Elsevier Inc. 225
Copyright 0 1993 by the Genetics Society of America The Drosophilastubaristu Phenotype Is Associated Witha Dosage
The Autosomal FLP-DFS Technique for Generating Germline Mosaics in DrosqPhila melanogaster
Identification of Neural Outgrowth Genes using Genome-Wide RNAi
Genome-wide high-throughput screens in functional genomics Adam Friedman and Norbert Perrimon1
Drosophila as a model system to study autophagy Jonathan Zirin & Norbert Perrimon
Developmental Cell, Vol. 7, 535545, October, 2004, Copyright 2004 by Cell Press Small Wing PLC Is Required
Introduction Communication between cells during developmental
Supplementary Figure 1 TSG experimental strategy.
The orthodenticle gene encodes a novel homeo domain protein involved in the
DEVELOPMENTAL BIOLOGY 127,392-407 (1988) The Maternal Effect of lethal(l)dislarge-I: A Recessive
INFECTION AND IMMUNITY, Aug. 2005, p. 50655073 Vol. 73, No. 8 0019-9567/05/$08.00 0 doi:10.1128/IAI.73.8.50655073.2005
MOLECULAR AND CELLULAR BIOLOGY, Mar. 2002, p. 17921803 Vol. 22, No. 6 0270-7306/02/$04.00 0 DOI: 10.1128/MCB.22.6.17921803.2002
Drosophila and the genetics of the internal milieu
ELSEVIEZR Mechanisms of Development 58 (1996) 15-26 Conservation of dishevelled structure and function between flies and mice
Activation of the JNK pathway during dorsal closure in Drosophila requires
308 | VOL.4 NO.4 | APRIL 2007 | NATURE METHODS NEWS AND VIEWS
Proc. Natl. Acad. Sci. USA Vol. 94, pp. 1483714842, December 1997
Copyright 0 1988 by the Genetics Society of America Genetic Evidence That thesansfille Locus Is Involved in Drosophila Sex
Quantitative Variations in the Level of MAPK Activity Control Patterning of the Embryonic
SUPPLEMENTARY ONLINE MATERIAL MATERIALS AND METHODS
Supplemental Data BMP Signaling Is Required for Controlling
964 Research Paper A cyclase-associated protein regulates actin and cell polarity
6. L. W. Cheng, D. A. Portnoy, Cell. Microbiol. 5, 875 (2003). 7. B. E. Mansfield, M. S. Dionne, D. S. Schneider, N. E.
Cell, Vol. 89, 1316, April 4, 1997, Copyright 1997 by Cell Press There Must Be 50 Ways to Rule Minireview
Monitoring the T cell response to genital tract infection
INTRODUCTION Myosins are a superfamily of actin-dependent molecular motor
DEVELOPMENTAL BIOLOGY 100, 365-373 (1983) Clonal Analysis of the Tissue Specificity of Recessive Female-Sterile
Developmental Cell, Vol. 3, 765778, December, 2002, Copyright 2002 by Cell Press ReviewThe JAK/STAT Pathway
independently in hV0 studies. as x~ppre~sors of the gain-of-function
VOLUME 11 NUMBER 9 SEPTEMBER 2009 www.cell-micro.com ISSN 1462-5814 Thematic Reviews: Innate Defenses
Cell Host & Microbe Short Review
DEVELOPMENTAL BIOLOGY 139,169-185 (1990) Genetic Dissection of a Complex Neurological
DEVELOPMENTAL GENETICS 13:367375 (1992) Use of a Yeast Site-SpecificRecombinase to
Creating mosaics in Drosophila NORBERT PERRIMON*
Copyright 0 1989 by the Genetics Society of America Zygotic Lethals WithSpecific Maternal Effect Phenotypes in
Stimulation of Enhanced CD8 T Cell Responses Following Immunization with a Hyper-Antigen Secreting Intracytosolic
Cell, Vol. 92, 697700, March 20, 1998, Copyright 1998 by Cell Press Mammalian and Drosophila Blood: Minireview
Supplementary Material The Emergence of Geometric Order in Proliferating
All for one, and one for all: the clonality of the intestinal stem Phillip Karpowicz1
www.sciencemag.org/cgi/content/full/316/5832/1753/DC1 Supporting Online Material for
Nature Macmillan Publishers Ltd 1998 Tout-velu is a Drosophila
2767RESEARCH ARTICLE INTRODUCTION
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Feb. 2009, p. 756764 Vol. 53, No. 2 0066-4804/09/$08.00 0 doi:10.1128/AAC.00607-08
Listeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles
2007LANDESBIOSCIENCE.DONOTDISTRIBUTE. e1 Autophagy 2007;Vol.3Issue5
Genomic approaches to understanding bacterial virulence Laura S Burrack and Darren E Higgins
Directed antigen delivery as a vaccine strategy for an intracellular bacterial pathogen
Molecular Microbiology (2005) 57(5), 14601473 doi:10.1111/j.1365-2958.2005.04780.x 2005 Blackwell Publishing Ltd
skeletal muscle membranes of puffer fish Fugu pardalis and the primary structure of a voltage-gated channel a-subunit (fMNa1) from skeletal muscle of F. pardalis. Biochem. Biophys. Res. Commun.
Escherichia coli Expressing Recombinant Antigen and Listeriolysin O Stimulate Class I-Restricted CD8 T Cells
JOURNAL OF BACTERIOLOGY, Nov. 2003, p. 62956307 Vol. 185, No. 21 0021-9193/03/$08.00 0 DOI: 10.1128/JB.185.21.62956307.2003
JOURNAL OF BACTERIOLOGY, Nov. 2002, p. 59355945 Vol. 184, No. 21 0021-9193/02/$04.00 0 DOI: 10.1128/JB.184.21.59355945.2002
J. Embryol. exp. Morph. 84,275-286 (1984) 2 7 5 Printed in Great Britain The Company of Biologists Limited 1984
DEVELOPMENTAL BIOLOGY 110,480-491 (1985) A Pupal Lethal Mutation with a Paternally Influenced Maternal Effect on
Copyright 0 1985 by the Genetics Society of America DEVELOPMENTAL GENETICS OF T H E 2C-D REGION OF
DEVELOPMENTAL BIOLOGY 115,479-489 (1986) Developmental Analysis of the Torso-like Phenotype in Drosophila
Copyright 0 1986 by the Genetics Society of America X-LINKED FEMALE-STERILE LOCI IN DROSOPHZLA
DEVELOPMENTAL BIOLOGY 118,28-41 (1986) l(l)hopscotch, a Larval-Pupal Zygotic Lethal with a Specific
DEVELOPMENTAL BIOLOGY 119,587600 (1987) Multiple Functions of Segment Polarity Genes in Drosophila
10.1101/gad.2.7.830Access the most recent version at doi: 1988 2: 830-842Genes Dev.
Development 105, 629-638 (1989) Printed in Great Britain The Company of Biologists Limited 1989
Development 106, 145-158 (1989) Printed in Great Britain The Company of Biologists Limited 1989
10.1101/gad.5.6.1080Access the most recent version at doi: 1991 5: 1080-1091Genes Dev.
Copyright0 1992 by the Genetics Society of America Genetic and Developmental Analysisof Polytene Section17 of the
Copyright 0 1992 by the Genetics Society of America Use of a Yeast Sitespecific Recombinase to Produce Female Germline
Introduction Anterior-posterior patterning in the Drosophila embryo is
INTRODUCTION The ability to express a gene in a directed fashion is a useful
Simple and efficient generation of marked clones in Drosophila
The EMBO Journal vol. 1 2 no. 1 3 pp. 5293 -5302, 1993 Mutations in the segment polarity genes wingless and
10.1101/gad.8.1.118Access the most recent version at doi: 1994 8: 118-130Genes Dev.
10.1101/gad.8.3.300Access the most recent version at doi: 1994 8: 300-312Genes Dev.
MOLECULAR AND CELLULAR BIOLOGY, Sept. 1995, p. 51235130 Vol. 15, No. 9 0270-7306/95/$04.00 0
INTRODUCTION The segment polarity genes wingless (wg) and engrailed (en)
Cell, Vol. 84, 411419, February 9, 1996, Copyright 1996 by Cell Press marelle Acts Downstream
DEVELOPMENTAL BIOLOGY 178, 6376 (1996) ARTICLE NO. 0198
INTRODUCTION Epithelia are one of the universal architectural units used in the
Inhibition of patterned cell shape change and cell invasion by Discs large during
INTRODUCTION From a single cell with finite resources, the process of
Proc. Natl. Acad. Sci. USA Vol. 95, pp. 97169717, August 1998
Differential recruitment of Dishevelled provides signaling specificity
Drosophila unpaired encodes a secreted protein that activates the JAK
1999 Macmillan Magazines Ltd Dally cooperates with
INTRODUCTION The Drosophila EGF receptor (DER) belongs to a large family
Cooperative Regulation of Cell Polarity and Growth by
Multiple Roles for four-jointed in Planar Polarity and Limb Patterning
INTRODUCTION Morphogenesis refers to the creation of biological structure, or
The Drosophila JNK Pathway Controls the Morphogenesis of the Egg Dorsal Appendages
letters to nature 634 NATURE |VOL 414 |6 DECEMBER 2001 |www.nature.com
INTRODUCTION The four known members of the mammalian ErbB family of cell
INTRODUCTION Hh proteins make up a conserved family of secreted signaling
Analysis of Twenty-Four Gal4 Lines in Drosophila melanogaster
Neuron, Vol. 36, 611622, November 14, 2002, Copyright 2002 by Cell Press A Drosophila Homolog of Cyclase-Associated
NATURE CELL BIOLOGY VOL 5 JANUARY 2003 www.nature.com/naturecellbiology 53 Integrated activity of PDZ protein
-Secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila1
Research article A functional genomic analysis of cell morphology using RNA
amount of a mica-like (same as illite-like) phase (with 1.0-nm spacing) was also ob-
Developmental Cell, Vol. 7, 7384, July, 2004, Copyright 2004 by Cell Press The PDGF/VEGF Receptor Controls
Materials and Methods (1) Constructs
Introduction Morphogenetic movements such as cell migration are crucial
Science Supporting Online Material Drosophila RNAi Screen Reveals CD36 Family Member Required for
size of CdiB. Proteolytic fragments of CdiA were detected in the growth medium (5) but
2007 21: 875-877Genes & Dev. http://www.genesdev.org/cgi/content/full/21/7/875#References
Supplementary Figure 1. Secondary Assays (A) Schematic representation of the secondary assays done to control for promoter or luciferase specific effects. The
FlyRNAi: the Drosophila RNAi screening center database
Supplemental Figure legends Figure S1: Whole mount adult Drosophila gastrointestinal tract imaged in cross-section
A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling
Functional screening identifies miR-315 as a potent activator of Wingless signaling
Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster
http://jbx.sagepub.com Journal of Biomolecular Screening
1439RESEARCH ARTICLE INTRODUCTION
Molecular Cell Comparative Analysis of Argonaute-Dependent
SUPPLEMENTARY MATERIAL Integration of Insulin Receptor/FOXO signaling and dMyc activity during
INTRODUCTION Huntington's disease (HD) is an autosomal dominant, progressive
Copyright 2009 by the Genetics Society of America DOI: 10.1534/genetics.109.103630
The twin spot generator for differential Drosophila
Supporting Information Apidianakis et al. 10.1073/pnas.0911797106
Supporting Information Schnall-Levin et al. 10.1073/pnas.1006172107
3615RESEARCH ARTICLE INTRODUCTION
4135DEVELOPMENT AND STEM CELLS RESEARCH ARTICLE INTRODUCTION
Sarcomere Formation Occurs by the Assembly of Multiple Latent Protein Complexes
DOI: 10.1126/science.1198374 , 1787 (2010);330Science
10.1101/gr.112961.110Access the most recent version at doi: published online December 22, 2010Genome Res.
10.1101/gr.116657.110Access the most recent version at doi: published online December 22, 2010Genome Res.
Cell, Vol. 86, 513516, August 23, 1996, Copyright 1996 by Cell Press Serpentine Proteins Minireview
Nature Macmillan Publishers Ltd 1998 More sophisticated ecological approach-
NATURE |VOL 404 |13 APRIL 2000 |www.nature.com 725 Specicities of heparan
2000 Macmillan Magazines Ltd NATURE CELL BIOLOGY | VOL 2 | APRIL 2000 | www.nature.com/ncb E53
doi:10.1006/scdb.2000.0237, available online at http://www.idealibrary.com on seminars in CELL & DEVELOPMENTAL BIOLOGY, Vol. 12, 2001: pp. 6567
tion (22, 23). In addition to hPR-A (the human progesterone receptor A isoform), other pro-
The Hedgehog (Hh) family of signaling molecules are key agents in patterning numerous types of tissues. Mutations in Hh
news and views NATURE CELL BIOLOGY VOL 4 SEPTEMBER 2002 www.nature.com/naturecellbiology E211
Using RNAi to catch Drosophila genes in a web of interactions: insights into cancer research
*Department of Experimental Medical
PreviewsSuper-size flies The increasing prevalence of obesity and other nutrition-related chronic diseases has prompted considerable efforts to
Tissue culture cells have provided a powerful system for studying many fundamental problems in signal
Methods 40 (2006) 262271 www.elsevier.com/locate/ymeth
Proliferation zone Differentiation
Culture of Drosophila primary cells dissociated from gastrula embryos and their use in RNAi screening
conundrum (Liang and Biggin, 1998). In the embryo, most randomly selected
Steroids Make You Bigger? Fat Chance Says Myc Akhila Rajan1 and Norbert Perrimon1,2,*
Focus Article Where gene discovery turns into
RNA interference: Mechanisms and Applications Norbert Perrimon, Tony Hyman
The completion of the Drosophila genome sequence in 2000 (Adams et al. 2000) has conceptually changed the
10.1101/gad.6.8.1503Access the most recent version at doi: 1992 6: 1503-1517Genes Dev.
Identification of adult midgut precursors in Drosophila Craig A. Micchelli a,,1
10.1101/gad.10.5.566Access the most recent version at doi: 1996 10: 566-577Genes Dev.
INTRODUCTION Overactivation of receptor tyrosine kinases (RTKs), caused by
An endogenous small interfering RNA pathway in Benjamin Czech1
DEVELOPMENTAL GENETICS 12238-252 (19911 Generating Lineage-SpecificMarkers To Study
ESCRT factors restrict mycobacterial growth Jennifer A. Philips*, Maura C. Porto*, Hui Wang*, Eric J. Rubin
Vector and parameters for targeted transgenic
INTRODUCTION Drosophila Wingless (Wg) belongs to a family of highly
Cell, Vol. 106, 399402, August 24, 2001, Copyright 2001 by Cell Press MinireviewDoublesex Surprises
Copyright 2009 by the Genetics Society of America DOI: 10.1534/genetics.109.106567
Heparan sulfate proteoglycans (HSPGs) are associated with the cell surface and covalently linked to a small number of long
Genomic Screening with RNAi: Results and Challenges
Detailed Online Methods A 3xFLAG-HA tag was inserted at the N-terminus of AGO2-RB into BAC
983RESEARCH ARTICLE INTRODUCTION
Phosphorylation Networks Regulating JNK Activity in Diverse
Glycoconjugate Journal 19, 363368, 2003 C 2003 Kluwer Academic Publishers. Manufactured in The Netherlands.
Control of the Mitotic Cleavage Plane by Local Epithelial Topology
XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk
Differential function of Listeria monocytogenes listeriolysin O and phospholipases C in vacuolar
Cell, Vol. 70, 225-236, July 24, 1992, Copyright Q 1992 by Cell Press corkscrew Encodes a Putative Protein Tyrosine
INTRODUCTION The fibroblast growth factors (FGFs) constitute a large family
NATURE CELL BIOLOGY VOL 3 OCTOBER 2001 http://cellbio.nature.com Spatial control of the actin
Copyright 0 1997 by the Genetics Society of America A New Enhancer of Position-Effect Variegationin Drosophila melunogaster
Molecular Cell, Volume 32 Supplemental Data
10.1101/gad.8.18.2176Access the most recent version at doi: 1994 8: 2176-2187Genes Dev.
www.sciencesignaling.org/cgi/content/full/4/154/rs1/DC1 Supplementary Materials for
10.1101/gad.10.24.3116Access the most recent version at doi: 1996 10: 3116-3128Genes Dev.
Copyright 0 1984 by the Genetics Society of America DEVELOPMENTAL GENETICS OF T H E 2E-F REGION OF
2509Correspondence Several recent papers published in Development challenge
MOLECULAR AND CELLULAR BIOLOGY, June 1990, p. 3232-3238 0270-7306/90/063232-07$02.00/0
2006 Nature Publishing Group Evidence that stem cells reside in the adult
JOURNAL OF BACTERIOLOGY, June 2007, p. 44184424 Vol. 189, No. 12 0021-9193/07/$08.00 0 doi:10.1128/JB.01967-06
The Wingless morphogen gradient is established by the cooperative action of Frizzled and Heparan Sulfate Proteoglycan receptors
ARTICLE IN PRESS Mutational analysis reveals separable DNA binding and trans-activation
The roles of JAK/STAT signaling in Drosophila immune responses
DEVELOPMENTAL BIOLOGY 119,175-189 (1987) Region-Specific Defects in I(l)gi Embryos of Drosophila melanogaster
# Supplemental Figure 1 -Fig. S1. yanP(lacZ) is expressed in outer border cells but not in polar cells. (A) Stage 9 and (B) stage 10 yanP(lacZ) egg chamber stained with
Gene Expression Patterns xxx (2006) xxxxxx www.elsevier.com/locate/modgep
INTRODUCTION Heparan sulfate proteoglycans (HSPGs) are abundant cell-
Molecular Cell Hierarchical Rules for Argonaute
INTRODUCTION The Drosophila gene wingless (wg) encodes a secreted glyco-
Stress signaling in Drosophila Beth E Stronach*,1
DEVELOPMENTAL BIOLOGY 134,130-145 (1989) The Segment Polarity Phenotype of Drosophila Involves Differential
Materials and Methods Bacterial and eukaryotic cell growth conditions. Listeria monocytogenes strains were
Genome Biology 2007, 8:R203 commentreviewsreportsdepositedresearchrefereedresearchinteractionsinformation
Proc. Nail. Acad. Sci. USA Vol. 89, pp. 1919-1923, March 1992
Listeria monocytogenes as a Vaccine Vector: Virulence Attenuation or Existing Antivector Immunity Does Not
Yantar, a conserved arginine-rich protein is involved in Drosophila hemocyte development
The Host Resistance Locus sst1 Controls Innate Immunity to Listeria monocytogenes Infection in Immunodeficient Mice1
In vivo imaging of Drosophila melanogaster
2000 Macmillan Magazines Ltd news and views
Copyright 0 1984 by the Genetics Society of America CLONAL ANALYSIS OF DOMINANT FEMALE-STERILE,
Copyright 2007 by the Genetics Society of America DOI: 10.1534/genetics.106.069963
Copyright 2000 by the Genetics Society of America Identification of Autosomal Regions Involved in Drosophila Raf Function
The EMBO Journal vol.14 no. 12 pp.2857-2865, 1995 Activation of a Drosophila Janus kinase (JAK)
Supplemental Data Molecular Cell, Volume 36
The four-jointed gene is required in the Drosophila eye for ommatidial polarity specification
Dynamic Switch of Negative Feedback Regulation in Drosophila AktTOR Signaling
Nature Methods A genome-scale shRNA resource for transgenic RNAi in Drosophila
Copyright 0 1989 by the Genetics Society ofAmerica Developmental Geneticsof Loci at the Baseof the X Chromosome of
DEVELOPMENTAL BIOLOGY 180, 6381 (1996) ARTICLE NO. 0285
10.1101/gad.8.5.629Access the most recent version at doi: 1994 8: 629-639Genes Dev.
INTRODUCTION An amphibian egg is laid with a clear animal-vegetal polarity,
Cell, Vol. 97, 1316, April 2, 1999, Copyright 1999 by Cell Press Negative Feedback Mechanisms Minireview
ioscience.D distribute.
Copyright 2010 by the Genetics Society of America DOI: 10.1534/genetics.109.112516
MOLECULAR AND CELLULAR BIOLOGY, June 1987, p. 2134-2140 Vol. 7, No. 6 0270-7306/87/062134-07$02.00/0
Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing
Markstein et al. (2008) Nature Genetics Supplementary PDF Exploiting position effects and the gypsy retrovirus insulator to engineer
(154), rs1. [DOI: 10.1126/scisignal.2001350]4Science Signaling Shu Kondo and Norbert Perrimon (4 January 2011)
2006 Nature Publishing Group Functional genomics reveals genes involved in
Developmental Cell, Vol. 9, 651662, November, 2005, Copyright 2005 by Elsevier Inc. DOI 10.1016/j.devcel.2005.09.013 BMP Signaling Is Required for Controlling
Supplementary Figure 1 Mutations in inteinTS A schematic representation of a wild type VMA1 intein highlighting the regions (A-H &
Cellular Microbiology (2006) 8(1), 107119 doi:10.1111/j.1462-5822.2005.00604.x First published online 1 September 2005
2010;2:a003640 originally published online June 9, 2010Cold Spring Harb Perspect Biol Norbert Perrimon, Jian-Quan Ni and Lizabeth Perkins
Functional genomics reveals new genes involved in protein secretion and Golgi organization
REVIEWS Drug Discovery Today Volume 12, Numbers 1/2 January 2007 Drug-target identification in Drosophila
NATURE METHODS | VOL.3 NO.10 | OCTOBER 2006 | 777 Minimizing the risk of reporting false positives in
Live-cell imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography
Proc. Natl. Acad. Sci. USA Vol. 96, pp. 523528, January 1999
Polarity determination in the Drosophila eye: a novel role for Unpaired
FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide
INTRODUCTION Cell identity along the anteroposterior axis of the embryo
R682 Dispatch Sex determination: Co-opted signals determine gender
INTRODUCTION Signaling through the evolutionarily conserved cassette of
Design and implementation of high-throughput RNAi screens in cultured Drosophila cells
Listeria monocytogenes regulates flagellar motility gene expression through MogR, a transcriptional
A genome-wide RNA interference screen identifies putative chromatin regulators essential for
The MogR Transcriptional Repressor Regulates Nonhierarchal Expression of Flagellar Motility
The EMBO Journal vol. 13 no. 1 1 pp.2592 -2599, 1994 Genetic and molecular analyses of mutations involved in
nature | methods RNAiCut: automated detection of significant genes from
10.1101/gr.100248.109Access the most recent version at doi: 2010 20: 372-380 originally published online February 9, 2010Genome Res.
Functional Genomic Analysis of the Wnt-Wingless
Supporting Information Brouzes et al. 10.1073/pnas.0903542106
DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell
INTRODUCTION The establishment of the two major axes, anteroposterior (AP)
Supplementary File Title Supplementary Figure 1 TSG experimental strategy.
DEVELOPMENTAL BIOLOGY 135,287305 (1989) Multiple Functions of a Drosophila Homeotic Gene, zeste-white 3,
10.1101/gad.7.4.621Access the most recent version at doi: 1993 7: 621-632Genes Dev.
BioMed Central Page 1 of 20
Supplementary Information for Friedman and Perrimon, "A functional genomic RNAi screen for novel regulators of RTK and ERK signaling," 2006.
Supplementary Figure 1. Microarray analysis of off-target effects. Supplementary Figure 1a . Schematic of the genomic region of the PP2A-B' gene.
COPI Activity Coupled with Fatty Acid Biosynthesis Is Required for Viral Replication
INTRODUCTION The Drosophila compound eye is composed of approximately
2007LANDESBIOSCIENCE.DONOTDISTRIBUTE. Matter Arising
DOI: 10.1126/science.1140324 , 1753 (2007);316Science
Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes
www.sciencemag.org/cgi/content/full/322/5900/453/DC1 Supporting Online Material for
Advanced Review RNAi screening: new approaches,
www.sciencesignaling.org/cgi/content/full/4/196/rs10/DC1 Supplementary Materials for
RESEARCH ARTICLE Open Access An integrative approach to ortholog prediction
Supplemental Figure 1. Groove differentiation occurs before refinement is complete Early stage 12 embryo at the onset of groove formation, heat fixed and stained for aPKC,