- Supplemental Data Prolonged Rapamycin Treatment
- Cancer Cell 12, July 2007 2007 Elsevier Inc. Cancer Cell
- Current Biology 16, 16, September 19, 2006 2006 Elsevier Ltd All rights reserved DOI 10.1016/j.cub.2006.08.001 mSin1 Is Necessary for Akt/PKB
- Leading Edge Cell 134, September 5, 2008 2008 Elsevier Inc. 703
- DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma
- Cell Size Control David A Guertin, Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
- Redox Regulation of the Nutrient-sensitive Raptor-mTOR Pathway and Complex*
- Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary
- 21. J. Lee, W. G. Dunphy, Mol. Biol. Cell 21, 926 (2010). Acknowledgments: We thank the Institute of Chemistry
- Cancer Cell Defective Regulation of Autophagy upon
- Supplemental figures and legends, Supplemental table legends, and Methods Lindquist, et al. manuscript
- w w w. n a t u r e . c o m / n a t u r e | 1 SuPPLementarYInFormatIon doi:10.1038/nature09584
- `Growth' indicates the set of biochemical processes --intimately linked to the availability of nutrients and
- Molecular Cell Regulation of the mTOR Complex 1 Pathway
- Molecular Cell Short Article
- 10.1101/gr.106773.110Access the most recent version at doi: published online May 27, 2010Genome Res.
- Signaling and Regulation Rictor Phosphorylation on the Thr-1135 Site Does Not Require
- 396 525 622 709 808 923 1070 1184 1321 1408 1523 1638 1785 1886 1983 2657 24432556 2262 2133 2036 1949 1850 1735 1588 1474 1337 1250 1135 1020 873 147
- mTOR signaling at a Mathieu Laplante1,2
- Cell, Volume 137 Supplemental Data
- SUPPLEMENTARY INFORMATION 1www.nature.com/nature
- Cancer Cell mTOR Complex 2 Is Required for the Development
- DOI: 10.1126/science.1157535 , 1496 (2008);320Science
- Molecular Cell PRAS40 Is an Insulin-Regulated Inhibitor
- Molecular Cell, Volume 25 Supplemental Data
- Developmental Cell 11, 859871, December, 2006 2006 Elsevier Inc. DOI 10.1016/j.devcel.2006.10.007 Ablation in Mice of the mTORC Components raptor,
- Stress and mTORture signaling JH Reiling and DM Sabatini
- Molecular Cell 22, 159168, April 21, 2006 2006 Elsevier Inc. DOI 10.1016/j.molcel.2006.03.029 Prolonged Rapamycin Treatment
- An expanding role for mTOR in cancer David A. Guertin1
- Microarrays of small molecules embedded in biodegradable polymers for use in mammalian
- Current Biology, Vol. 14, 12961302, July 27, 2004, 2004 Elsevier Ltd. All rights reserved. DOI 10.1016/j.cub.2004.06.054 Rictor, a Novel Binding Partner of mTOR, Defines
- Molecular Cell, Vol. 11, 895904, April, 2003, Copyright 2003 by Cell Press G L, a Positive Regulator of the Rapamycin-
- Lentivirus-delivered stable gene silencing by RNAi in primary cells
- Cell, Vol. 110, 163175, July 26, 2002, Copyright 2002 by Cell Press mTOR Interacts with Raptor to Form
- Hentges et al FRAP/mTOR is required for proliferation and patterning during
- Proc. Natl. Acad. Sci. USA Vol. 95, pp. 14321437, February 1998
- Cancer Cell, Volume 15 Supplemental Data
- letters to nature NATURE |VOL 411 |3 MAY 2001 |www.nature.com 107
- Current Biology 16, 113, May 23, 2006 2006 Elsevier Ltd All rights reserved DOI 10.1016/j.cub.2006.03.084 Functional Genomics Identifies
- SUPPLEMENTAL DATA An ATP-competitive mTOR inhibitor reveals rapamycin-resistant functions of mTORC1
- mTOR Mediated Anti-Cancer Drug Discovery Qingsong Liu1,2, Carson Thoreen3,4, Jinhua Wang1,2, David Sabatini3,4,5, and Nathanael S.
- MOLECULAR AND CELLULAR BIOLOGY, Apr. 2002, p. 21112123 Vol. 22, No. 7 0270-7306/02/$04.00 0 DOI: 10.1128/MCB.22.7.21112123.2002
- Highly parallel identification of essential genes in cancer cells
- Developmental Cell 11 Supplemental Data
- S1Supplemental Data Rictor, a Novel Binding Partner of mTOR, Defines
- www.sciencemag.org/cgi/content/full/1157535/DC1 Supporting Online Material for
- Supplemental Data S1 Functional Genomics Identifies
- TRENDS in Cell Biology Vol.12 No.10 October 2002 http://tcb.trends.com 0962-8924/02/$ see front matter 2002 Elsevier Science Ltd. All rights reserved. PII: S0962-8924(02)02354-1
- Regulation of the Rapamycin and FKBP-Target 1/Mammalian Target of Rapamycin and Cap-dependent Initiation of Translation by the
- Supplemental Data S1 mSin1 Is Necessary for Akt/PKB
- Growing roles for the mTOR pathway Dos D Sarbassov, Siraj M Ali and David M Sabatini
- nated from further analysis because they were sig-nificantly more active preceding saccades to T2 than
- Published: February 15, 2011 r 2011 American Chemical Society 1473 dx.doi.org/10.1021/jm101520v |J. Med. Chem. 2011, 54, 14731480
- MOLECULAR AND CELLULAR BIOLOGY, Aug. 2002, p. 55755584 Vol. 22, No. 15 0270-7306/02/$04.00 0 DOI: 10.1128/MCB.22.15.55755584.2002
- Current Biology 19, R1046R1052, December 1, 2009 2009 Elsevier Ltd All rights reserved DOI 10.1016/j.cub.2009.09.058 MinireviewAn Emerging Role of mTOR in Lipid
- 1359-6446/02/$ see front matter 2002 Elsevier Science Ltd. All rights reserved. PII: DDT Vol. 7, No. 18 (Suppl.), 2002
- Proc. Natl. Acad. Sci. USA Vol. 95, pp. 83518356, July 1998
- An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions
- mTOR and cancer: insights into a complex relationship
- (67), pe24. [DOI: 10.1126/scisignal.267pe24]2Science Signaling David A. Guertin and David M. Sabatini (21 April 2009)
- Molecular Cell, Volume 38 Supplemental Information
- Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
- The Rapamycin and FKBP12 Target (RAFT) Displays
- Supplemental Data A Lentiviral RNAi Library for Human
- Tumours with PI3K activation are resistant to dietary restriction
- Native Capillary Isoelectric Focusing for the Separation of Protein Complex Isoforms and
- further careful investigation. For example, although the authors found that Ang1
- Molecular Cell Increased mTORC1 Signaling
- Structure of S6 Kinase 1 Determines whether Raptor-
- pubs.acs.org/jmc Published on Web 09/22/2010 r 2010 American Chemical Society 7146 J. Med. Chem. 2010, 53, 71467155
- LETTER doi:10.1038/nature09584 mTORC1 controls fasting-induced ketogenesis and
- of intra-Golgi transport. Other tethers should identify other subpopulations, allowing us
- 2006 Nature Publishing Group Genome sequencing has ushered in the need for new
- Sarbassov et al. 1 Supporting Online Material
- LETTER doi:10.1038/nature10350 Functional genomics reveal that the serine synthesis
- Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse
- Belikova, N.A., Kapralov, A.A., Kini, V., et al. (2005). Nat. Chem. Biol. 4, 223232.
- mTOR Complex 1 Regulates Lipin 1 Localization to Control
- DOI: 10.1126/science.1207552 , 923 (2011);332Science
- A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key
- Cell Metabolism Postprandial Hepatic Lipid Metabolism
- DOI: 10.1126/science.1207056 , 678 (2011);334Science
- mTOR Signaling Mathieu Laplante and David M. Sabatini
- Thomas Weichhart (ed.), mTOR: Methods and Protocols, Methods in Molecular Biology, vol. 821, DOI 10.1007/978-1-61779-430-8_29, Springer Science+Business Media, LLC 2012
- Selectivity and binding kinetics of mTOR inhibitors Kinome-wide selectivity profiling of ATP-competitive mTOR (mammalian target of rapamycin)
- A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR
