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- Incorporating Synthetic Oligonucleotides via Gene Reassembly (ISOR): a versatile tool for generating
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- Avoiding and controlling double transformation Moshe Goldsmith1, Csaba Kiss2, Andrew R.M. Bradbury2
- Antibody Multispecificity Mediated by Conformational
- NATURE METHODS | VOL.3 NO.7 | JULY 2006 | 561 Directed evolution by in vitro
- In vitro compartmentalization by double emulsions: sorting and gene enrichment by fluorescence activated cell sorting
- nderstanding the emer-genceofnewproteinfunct-
- Directed Evolution of the Promiscuous Esterase Activity of Carbonic Anhydrase II Stephen McQ. Gould and Dan S. Tawfik*
- In the past few years, a variety of methods have been developed to allow the in vitro evolution of a range of
- A structural model of latent evolutionary potentials underlying neutral networks in proteins
- How Protein Stability and New Functions Trade Off Nobuhiko Tokuriki1
- The Catalytic Histidine Dyad of High Density Lipoprotein-associated Serum Paraoxonase-1 (PON1) Is Essential for
- Directed evolution of phosphotriesterase from Pseudomonas diminuta for heterologous
- Robustnessepistasis link shapes the fitness landscape of a randomly drifting protein
- Investigating the target recognition of DNA cytosine-5 methyltransferase HhaI by library
- On the Magnitude and Specificity of Medium Effects in Enzyme-like Catalysts for Proton Transfer
- www.sciencemag.org SCIENCE VOL 299 28 FEBRUARY 2003 1327 rystallographers have noted that an an-
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- 692 nature chemical biology | VOL 6 | OCTOBER 2010 | www.nature.com/naturechemicalbiology Messy biology and the origins
- Chemistry & Biology, Vol. 12, 12551258, December, 2005, 2005 Elsevier Ltd All rights reserved. DOI 10.1016/j.chembiol.2005.11.006 The Laboratory in a Droplet
- NATURE METHODS | VOL.3 NO.7 | JULY 2006 | 545 Amplification of complex gene libraries
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- COMMUNICATION Reconstruction of Functional -Propeller Lectins via
- ANRV413-BI79-11 ARI 5 March 2010 22:38 Enzyme Promiscuity
- This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
- Structure-Reactivity Studies of Serum Paraoxonase PON1 Suggest that Its Native Activity Is Lactonase
- Metamorphic proteins mediate evolutionary transitions of structure
- Enhanced stereoselective hydrolysis of toxic organophosphates by directly evolved variants of
- December 8, 2003 Volume 81, Number 49
- Functional b-propeller lectins by tandem duplications of repetitive units
- Please cite this article in press as: Y. Ashani, et al., Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers, Chem. Biol. Interact. (2010), doi:10.1016/j.
- This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
- pubs.acs.org/Biochemistry Published on Web 12/21/2009 r 2009 American Chemical Society 532 Biochemistry 2010, 49, 532538
- Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase
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- COSTBI-702; NO OF PAGES 9 Please cite this article in press as: Tokuriki N, Tawfik DS. Stability effects of mutations and protein evolvability, Curr Opin Struct Biol (2009), doi:10.1016/j.sbi.2009.08.003
- nature structural & molecular biology VOLUME 16 NUMBER 10 OctOBER 2009 1049 a rt i c l e s
- Chaperonin overexpression promotes genetic variation and enzyme evolution
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- Potential role of phenotypic mutations in the evolution of protein expression and stability
- Directed enzyme evolution via small and effective
- Ohno's Model Revisited: Measuring the Frequency of Potentially Adaptive Mutations under Various Mutational Drifts
- Available online at www.sciencedirect.com Advances in laboratory evolution of enzymes
- NATURE METHODS | VOL.4 NO.12 | DECEMBER 2007 | 991 Protein engineers turned evolutionists
- Accelerated Publications The Latent Promiscuity of Newly Identified Microbial Lactonases Is Linked to a
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- Full text provided by www.sciencedirect.com Miniaturising the laboratory in
- Chemistry & Biology, Vol. 12, 12811289, December, 2005, 2005 Elsevier Ltd All rights reserved. DOI 10.1016/j.chembiol.2005.09.012 High-Throughput Screening of Enzyme Libraries
- DOI: 10.1002/cbic.200500334 Chromogenic and Fluorogenic
- discrimination mechanism in antigen recognition Structure and kinetics of a transient antibody binding intermediate reveal a kinetic
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- High-throughput screens and selections of enzyme-encoding Amir Aharoni1
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- December 8, 2003 ONLINE EXCLUSIVE
- The subtle benefits of being promiscuous: adaptive evolution potentiated by
- NEWS & VIEWS NATURE|Vol 440|9 March 2006 translated from that DNA, and to the myriad
- Provided for non-commercial research and educational use only. Not for reproduction, distribution or commercial use.
- pubs.acs.org/Biochemistry Published on Web 06/04/2009 r 2009 American Chemical Society 6644 Biochemistry 2009, 48, 66446654
- Shared Promiscuous Activities and Evolutionary Features in Various Members of the Amidohydrolase Superfamily
- Helen M.Cohen1, Dan S.Tawk2 and Andrew D.Grifths3,4
- To understand the evolution of gene and protein func-tion necessitates a mechanistic model that describes
- Efficient Catalysis of Proton Transfer by Synzymes Florian Hollfelder, Anthony J. Kirby,* and Dan S. Tawfik*,
- The Stability Effects of Protein Mutations Appear to be Universally Distributed
- Initial Mutations Direct Alternative Pathways of Protein Merijn L. M. Salverda1
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- pubs.acs.org/biochemistry Published on Web 01/07/2011 r 2011 American Chemical Society 1128 Biochemistry 2011, 50, 11281134
- Published: February 18, 2011 r 2011 American Chemical Society 2683 dx.doi.org/10.1021/bi101763c |Biochemistry 2011, 50, 26832690
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- Divergence and Convergence in Enzyme Evolution: Parallel