Bear, Mark - Picower Institute for Learning and Memory & Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT)

• Metaplasticity: the plasticity of synaptic Wickliffe C. Abraham and Mark F. Bear
• Proc. Natl. Acad. Sci. USA Vol. 96, pp. 94579458, August 1999
• 95:2947-2950, 2006. First published Feb 15, 2006; doi:10.1152/jn.01328.2005J Neurophysiol Michael A. Paradiso and Mark F. Bear
• Correction of Fragile X Syndrome in Mice Gu l Do len,1,2 Emily Osterweil,1 B.S. Shankaranarayana Rao,3 Gordon B. Smith,1 Benjamin D. Auerbach,1
• 0270.6474/83/0302-0407$02.00/O The Journal of Neuroscience Copyright 0 Society for Neuroscience Vol. 3, No. 2, pp. 407-416
• Obligatory Role of NR2A for Metaplasticity in Visual Cortex
• Published online 10 March 2003 Bidirectional synaptic plasticity: from theory to reality
• Neuron, Vol. 40, 595607, October 30, 2003, Copyright 2003 by Cell Press Ubiquitination Regulates PSD-95 Degradation
• 1999 Macmillan Magazines Ltd letters to nature
• Heterosynaptic metaplasticity in the hippocampus in vivo: A BCM-like modifiable threshold for LTP
• idly, had immediate, major, and visible impacts on the island_s biota and physical landscape, and
• The Journal of Neuroscience, May 1994, 74(5): 34043412 Homosynaptic Long-Term Depression in the Visual Cortex
• Effects of the Metabotropic Glutamate Receptor Antagonist MCPG on Phosphoinositide Turnover and Synaptic Plasticity in
• Proc. Natl. Acad. Sci. USA Vol. 93, pp. 1345313459, November 1996
• Learning Induces Long-Term Potentiation in the Hippocampus
• Neuron, Vol. 29, 157169, January, 2001, Copyright 2001 by Cell Press Visual Experience and Deprivation
• 352 nature neuroscience volume 2 no 4 april 1999 The neuronal response to glutamate released at excitatory syn-
• JOURNAL OF CELLULAR PHYSIOLOGY 200:309317 (2004) Significance of N-Methyl-D-Aspartate (NMDA)
• Role for A Kinase-anchoring Proteins (AKAPS) in Glutamate Receptor Trafficking and Long Term Synaptic Depression*
• The Journal of Neuroscience, March 1990, 7~73): 909-925 Disruption of Experience-Dependent Synaptic Modifications in Striate
• nature neuroscience volume 2 no 4 april 1999 309 scientific correspondence
• Fragile X: Translation in Action Mark F Bear*,1
• Therapeutic implications of the mGluR theory of fragile X mental retardation
• Small, G.W., Mazziotta, J.C., Collins, M.T., Baxter, L.R., Phelps, M.E., Mandelkern, M.A., Kaplan, A., La Rue, A., Adamson, C.F.,
• Neuron, Vol. 44, 917923, December 16, 2004, Copyright 2004 by Cell Press ReportHow Monocular Deprivation
• Neuron, Vol. 44, 521, September 30, 2004, Copyright 2004 by Cell Press ReviewLTP and LTD
• Neuron, Vol. 38, 977985, June 19, 2003, Copyright 2003 by Cell Press NMDA Receptor-Dependent Ocular
• A unified model of NMDA receptor-dependent bidirectional synaptic plasticity
• Altered synaptic plasticity in a mouse model of fragile X mental retardation
• Neuron, Vol. 33, 665671, February 28, 2002, Copyright 2002 by Cell Press responses, previously described in slices of CA1 (XiaoSynaptic Plasticity in an Altered
• Long-Term Potentiation of Thalamocortical Transmission in the Adult Visual Cortex In Vivo
• A Role for the Cytoplasmic Polyadenylation Element in NMDA Receptor-Regulated mRNA Translation in Neurons
• Cell, Vol. 107, 617629, November 30, 2001, Copyright 2001 by Cell Press Forebrain-Specific Calcineurin Knockout
• Neuropharmacology 41 (2001) 762770 www.elsevier.com/locate/neuropharm
• Developmental Inhibitory Gate Controls the Relay of Activity to the Superficial Layers of the Visual Cortex
• Chemical Induction of mGluR5-and Protein SynthesisDependent Long-Term Depression in Hippocampal Area CA1
• Neuron, Vol. 28, 527536, November, 2000, Copyright 2000 by Cell Press Bidirectional, Activity-Dependent Regulation
• JOURNALOFNEUROPHYSIOLOGY Vol. 64, No. 4, October 1990. Printed in U.S.A.
• JOURNAL OF NEUROPHYSIOLOGY Vol. 74, No. 3, September 1995. Printed in U.S.A.
• Neuron, Vol. 15, 1-4, July, 1995, CopyrIght 0 1995 by Cell Press MinireviewMechanism for a Sliding Synaptic
• Neuron, Vol. 21, 11631175, November, 1998, Copyright 1998 by Cell Press Involvement of a Postsynaptic
• Cell, Vol. 98, 739755, September 17, 1999, Copyright 1999 by Cell Press BDNF Regulates the Maturation of Inhibition
• Modulation of Long-Term Synaptic Depression in Visual Cortex by Acetylcholine and Norepinephrine
• Proc. Nati. Acad. Sci. USA Vol. 86, pp. 4781-4784, June 1989
• Two mechanistically distinct forms of homosynaptic long-term depression (LTD) coexist in the hippocampus. Induction of one
• Cellular/Molecular A Morphological Correlate of Synaptic Scaling in
• Proc. Natl. Acad. Sci. USA Vol. 94, pp. 33803383, April 1997
• The mGluR theory of fragile X mental retardation
• The Journal of Neuroscience, July 1993, 13(7): 291 O-291 8 Bidirectional Long-Term Modification of Synaptic Effectiveness in the
• Development/Plasticity/Repair Bidirectional Modifications of Visual Acuity Induced by
• Neuron, Vol. 21, 11511162, November, 1998, Copyright 1998 by Cell Press NMDA Induces Long-Term Synaptic Depression
• Induction of NMDA Receptor-Dependent Long-Term Depression in Visual Cortex Does Not Require Metabotropic Glutamate Receptors
• 2000 Macmillan Magazines Ltd letters to nature
• mouse visual cortex Deprivation-induced synaptic depression by distinct mechanisms in different layers of
• Role for Rapid Dendritic Protein Synthesis in Hippocampal
• JOURNALOF NEUROPHYSIOLOGY Vol. 66, No. 5, November 1991. Printed in U.S.A.
• Molecular Basis for Induction of Ocular Dominance Plasticity
• Brief Communication Extracellular Signal-Regulated Protein Kinase Activation Is
• The Journal of Neuroscience Vol. 5, No. 5, pp. 1262-1275
• Neuropharmacology 37 (1998) 571579 Brain-derived neurotrophic factor alters the synaptic modification
• The Journal of Neuroscience, March 1994, 14(3): 1634-l 645 Hebbian Synapses in Visual Cortex
• Bidirectional, experience-dependent regulation of N-methyl-D-aspartate receptor subunit composition in
• JOURNALOF NEUROPHYSIOLOGY Vol. 67, No. 4, April 1992. Printed in U.S. A.
• JOURNAL OF CELLULAR PHYSIOLOGY 200:309317 (2004) Significance of N-Methyl-D-Aspartate (NMDA)
• JOURNALOF NEUROPHYSIOLOGY Vol. 67, No. 4, April 1992. Printed in U.S. A.
• Neuron, Vol. 44, 917923, December 16, 2004, Copyright 2004 by Cell Press ReportHow Monocular Deprivation
• Therapeutic implications of the mGluR theory of fragile X mental retardation
• The Journal of Neuroscience, March 1990, 7~73): 909-925 Disruption of Experience-Dependent Synaptic Modifications in Striate
• Induction of NMDA Receptor-Dependent Long-Term Depression in Visual Cortex Does Not Require Metabotropic Glutamate Receptors
• Neuron, Vol. 15, 1-4, July, 1995, CopyrIght 0 1995 by Cell Press MinireviewMechanism for a Sliding Synaptic
• Development/Plasticity/Repair Bidirectional Modifications of Visual Acuity Induced by
• Correction of Fragile X Syndrome in Mice Gu l Do len,1,2 Emily Osterweil,1 B.S. Shankaranarayana Rao,3 Gordon B. Smith,1 Benjamin D. Auerbach,1
• Small, G.W., Mazziotta, J.C., Collins, M.T., Baxter, L.R., Phelps, M.E., Mandelkern, M.A., Kaplan, A., La Rue, A., Adamson, C.F.,
• Cell, Vol. 107, 617629, November 30, 2001, Copyright 2001 by Cell Press Forebrain-Specific Calcineurin Knockout
• Role for A Kinase-anchoring Proteins (AKAPS) in Glutamate Receptor Trafficking and Long Term Synaptic Depression*
• JOURNAL OF NEUROPHYSIOLOGY Vol. 74, No. 3, September 1995. Printed in U.S.A.
• A Role for the Cytoplasmic Polyadenylation Element in NMDA Receptor-Regulated mRNA Translation in Neurons
• 2000 Macmillan Magazines Ltd letters to nature
• Neuron, Vol. 40, 595607, October 30, 2003, Copyright 2003 by Cell Press Ubiquitination Regulates PSD-95 Degradation
• Two mechanistically distinct forms of homosynaptic long-term depression (LTD) coexist in the hippocampus. Induction of one
• Molecular Basis for Induction of Ocular Dominance Plasticity
• Altered synaptic plasticity in a mouse model of fragile X mental retardation
• Bidirectional, experience-dependent regulation of N-methyl-D-aspartate receptor subunit composition in
• Developmental Inhibitory Gate Controls the Relay of Activity to the Superficial Layers of the Visual Cortex
• 0270.6474/83/0302-0407$02.00/O The Journal of Neuroscience Copyright 0 Society for Neuroscience Vol. 3, No. 2, pp. 407-416
• Cellular/Molecular A Morphological Correlate of Synaptic Scaling in
• A unified model of NMDA receptor-dependent bidirectional synaptic plasticity
• Proc. Natl. Acad. Sci. USA Vol. 94, pp. 33803383, April 1997
• Chemical Induction of mGluR5-and Protein SynthesisDependent Long-Term Depression in Hippocampal Area CA1
• nature neuroscience volume 2 no 4 april 1999 309 scientific correspondence
• Obligatory Role of NR2A for Metaplasticity in Visual Cortex
• JOURNALOF NEUROPHYSIOLOGY Vol. 66, No. 5, November 1991. Printed in U.S.A.
• Published online 10 March 2003 Bidirectional synaptic plasticity: from theory to reality
• The Journal of Neuroscience, March 1994, 14(3): 1634-l 645 Hebbian Synapses in Visual Cortex
• Metaplasticity: the plasticity of synaptic Wickliffe C. Abraham and Mark F. Bear
• The Journal of Neuroscience, May 1994, 74(5): 34043412 Homosynaptic Long-Term Depression in the Visual Cortex
• Proc. Natl. Acad. Sci. USA Vol. 96, pp. 94579458, August 1999
• Neuron, Vol. 21, 11631175, November, 1998, Copyright 1998 by Cell Press Involvement of a Postsynaptic
• Neuron, Vol. 38, 977985, June 19, 2003, Copyright 2003 by Cell Press NMDA Receptor-Dependent Ocular
• The Journal of Neuroscience, July 1993, 13(7): 291 O-291 8 Bidirectional Long-Term Modification of Synaptic Effectiveness in the
• Heterosynaptic metaplasticity in the hippocampus in vivo: A BCM-like modifiable threshold for LTP
• The mGluR theory of fragile X mental retardation
• idly, had immediate, major, and visible impacts on the island_s biota and physical landscape, and
• 352 nature neuroscience volume 2 no 4 april 1999 The neuronal response to glutamate released at excitatory syn-
• Learning Induces Long-Term Potentiation in the Hippocampus
• The Journal of Neuroscience Vol. 5, No. 5, pp. 1262-1275
• Proc. Nati. Acad. Sci. USA Vol. 86, pp. 4781-4784, June 1989
• Neuropharmacology 37 (1998) 571579 Brain-derived neurotrophic factor alters the synaptic modification
• Brief Communication Extracellular Signal-Regulated Protein Kinase Activation Is
• Proc. Natl. Acad. Sci. USA Vol. 93, pp. 1345313459, November 1996
• JOURNALOFNEUROPHYSIOLOGY Vol. 64, No. 4, October 1990. Printed in U.S.A.
• Neuron, Vol. 33, 665671, February 28, 2002, Copyright 2002 by Cell Press responses, previously described in slices of CA1 (XiaoSynaptic Plasticity in an Altered
• 1999 Macmillan Magazines Ltd letters to nature
• Cell, Vol. 98, 739755, September 17, 1999, Copyright 1999 by Cell Press BDNF Regulates the Maturation of Inhibition
• Neuron, Vol. 21, 11511162, November, 1998, Copyright 1998 by Cell Press NMDA Induces Long-Term Synaptic Depression
• Long-Term Potentiation of Thalamocortical Transmission in the Adult Visual Cortex In Vivo
• Effects of the Metabotropic Glutamate Receptor Antagonist MCPG on Phosphoinositide Turnover and Synaptic Plasticity in
• Neuron, Vol. 29, 157169, January, 2001, Copyright 2001 by Cell Press Visual Experience and Deprivation
• Neuron, Vol. 44, 521, September 30, 2004, Copyright 2004 by Cell Press ReviewLTP and LTD
• THE PICOWER FOR LEARNING AND MEMORY
• Modulation of Long-Term Synaptic Depression in Visual Cortex by Acetylcholine and Norepinephrine
• Role for Rapid Dendritic Protein Synthesis in Hippocampal
• Neuropharmacology 41 (2001) 762770 www.elsevier.com/locate/neuropharm
• Neuron, Vol. 28, 527536, November, 2000, Copyright 2000 by Cell Press Bidirectional, Activity-Dependent Regulation
• 95:2947-2950, 2006. First published Feb 15, 2006; doi:10.1152/jn.01328.2005J Neurophysiol Michael A. Paradiso and Mark F. Bear
• mouse visual cortex Deprivation-induced synaptic depression by distinct mechanisms in different layers of
• Fragile X: Translation in Action Mark F Bear*,1