Singer, Robert H. - Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Yeshiva University

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Singer, Robert H. - Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Yeshiva University

149149149149149Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 94, Suppl. I: 149-152, 1999 Trypanosoma cruzi-cardiomyocytes: New Contributions
Movement of nuclear poly(A) RNA throughout the interchromatin space in living cells
NEWS & VIEWS NATURE|Vol 438|24 November 2005 as a whole (the `majority vote') is given by
Localization of HIV RNA in Mitochondria of Infected Cells: Potential Role in Cytopathogenicity
nAture methods | VOL.8 NO.2 | FEBRUARY2011 | 165 live-cell single mrnA imaging is a powerful tool but has
Metabolic cycling in single yeast cells from unsynchronized steady-state populations limited on
Immunity, Vol. 20, 651, May, 2004, Copyright 2004 by Cell Press Structural and Functional Analysis of the Costimulatory Receptor
|Research Focus Gene expression and the myth of the average cell
ZBP1 recognition of b-actin zipcode induces RNA looping
MOLECULAR AND CELLULAR BIOLOGY, Dec. 2007, p. 83408351 Vol. 27, No. 23 0270-7306/07/$08.00 0 doi:10.1128/MCB.00972-07
Introduction The actin-related protein 2/3 (Arp2/3) complex is a stable
Real-Time Observation of Transcription Initiation and Elongation
Journalof Cellular Biochemistry52:125-126 (1993) Spatial Organization of mRNA Within Cells
THEJOURNALOFCELLBIOLOGY The Rockefeller University Press $8.00
Molecular and Cellular Pathobiology Altered Dynamics of Intestinal Cell Maturation in
The Rockefeller University Press, 0021-9525/97/03/1263/8 $2.00 The Journal of Cell Biology, Volume 136, Number 6, March 24, 1997 12631270 1263
The EMBO Journal Vol.17 No.13 pp.37473757, 1998 The snoRNA box C/D motif directs nucleolar
Cell, Vol. 119, 491502, November 12, 2004, Copyright 2004 by Cell Press She2p Is a Novel RNA Binding Protein
Molecular Cell, Vol. 2, 437445, October, 1998, Copyright 1998 by Cell Press Localization of ASH1 mRNA Particles
Leading Edge 722 Cell 134, September 5, 2008 2008 Elsevier Inc.
Butyrate and Vitamin D3 Induce Transcriptional Attenuation at
Terminal Minihelix, a Novel RNA Motif That Directs Polymerase III Transcripts to the Cell Cytoplasm
Proc. Natl. Acad. Sci. USA Vol. 96, pp. 66096614, June 1999
Molecular Biology of the Cell Vol. 16, 23952413, May 2005
QNQKE Targeting Motif for the SMN-Gemin Multiprotein Complex
Available online at www.sciencedirect.com Mechanisms and cellular roles of local protein synthesis in
vestigate longer-term trends in [CO3 PCO2. The observations made here also pro-
Molecular Biology of the Cell Vol. 18, 362368, February 2007
Dynamics of transcription and mRNA export Xavier Darzacq1,2
S1Supplemental Data Imaging Sites of N-WASP Activity in Lamellipodia
Journal of Pathology J Pathol 2008; 215: 445456
Journal of Cellular Biochemistry 102:609617 (2007) The Spatial Order of Transcription in Mammalian Cells
Journalof CellularBiochemistry44:241-252 (1990) Detectionand Localizationof Actin mRNA
RNA localization Yaron Shav-Tal and Robert H.
NATURE STRUCTURAL & MOLECULAR BIOLOGY VOLUME 18 NUMBER 1 JANUARY 2011 27 A RT I C L E S
MOLECULAR AND CELLULAR BIOLOGY, Nov. 1987, p. 4048-4057 0270-7306/87/114048-10$02.00/0
THEJOURNALOFCELLBIOLOGY JCB: ARTICLE
Single-Cell Transcription Site Activation Predicts Chemotherapy Response in Human Colorectal Tumors
A parafusin-related Toxoplasma protein in -regulated secretory organelles
A peptide motif in Raver1 mediates splicing repression by interaction with the PTB RRM2 domain
1895Research Article Introduction
RNA asymmetric distribution and daughter/mother differentiation in yeast
In vivo dynamics of RNA polymerase II transcription Xavier Darzacq1,2, Yaron Shav-Tal1,3, Valeria de Turris1, Yehuda Brody3, Shailesh M Shenoy1,
Neurobiology of Disease The Survival of Motor Neuron (SMN) Protein Interacts with
RNA Processing and Export Sami Hocine1
LETTER doi:10.1038/nature09438 In vivo imaging of labelled endogenous b-actin
PERSPECTIVE The cytoplasmic fate of an mRNP is
C H A P T E R E I G H T E E N Single mRNA Tracking in Live Cells
C H A P T E R T W E N T Y -S I X Analyzing mRNA Expression Using
Special Issue Imaging Cell Biology A single molecule view of gene
Single-RNA counting reveals alternative modes of gene expression in yeast
MOLECULAR AND CELLULAR BIOLOGY, Aug. 2008, p. 49634974 Vol. 28, No. 16 0270-7306/08/$08.00 0 doi:10.1128/MCB.00266-08
Myo2p, a class V myosin in budding yeast, associates with a large ribonucleic acidprotein complex that contains
Structural basis for the coevolution of a viral RNA
3173Short Report Introduction
788 VOLUME 14 NUMBER 9 SEPTEMBER 2007 NATURE STRUCTURAL & MOLECULAR BIOLOGY Transcription by RNA polymerase II (Pol II)
Published online 17 July 2007 Nucleic Acids Research, 2007, Vol. 35, No. 15 e94 doi:10.1093/nar/gkm510
THEJOURNALOFCELLBIOLOGY JCB: REPORT
Neurobiology of Disease Multiprotein Complexes of the Survival of Motor Neuron
Gene expression within a dynamic nuclear Yaron Shav-Tal1,
Nucleus and gene regulation Editorial overview
Genomes & Developmental Control Developmental timing in Dictyostelium is regulated by the Set1
2005 Nature Publishing Group Spatial regulation of b-actin translation by
Spatial regulation of -actin mRNA translation by Src-dependent phosphorylation of ZBP1 1 Supplementary Materials and Methods
The Great Escape: When Cancer Cells Hijack the
A new yeast PUF family protein, Puf6p, represses ASH1 mRNA translation
Cell, Vol. 116, 683698, March 5, 2004, Copyright 2004 by Cell Press From Silencing to Gene Expression
RNALocalizationand SignalTransduction
RNA Localization: Visualization in Robert H. Singer
Cellular Microbiology (2003) 5(9), 613624 doi:10.1046/j.1462-5822.2003.00305.x 2003 Blackwell Publishing Ltd
Early years The broader historical setting for the development of
Activity-Dependent Trafficking and Dynamic Localization of Zipcode Binding Protein 1 and -Actin mRNA in Dendrites
Molecular Cell, Vol. 10, 13191330, December, 2002, Copyright 2002 by Cell Press Asymmetric Sorting of Ash1p in Yeast
[CANCER RESEARCH 62, 71307133, December 1, 2002] Announcements
An active precursor in assembly of yeast nuclear ribonuclease P
Molecular Biology of the Cell Vol. 13, 579592, February 2002
The Rockefeller University Press, 0021-9525/2002/1/41/11 $5.00 The Journal of Cell Biology, Volume 156, Number 1, January 7, 2002 4151
Neuron, Vol. 31, 261275, August 2, 2001, Copyright 2001 by Cell Press Neurotrophin-Induced Transport of a -Actin
1010 Research Paper A Rho-dependent signaling pathway operating through myosin
The Rockefeller University Press, 0021-9525/2001/04/307/12 $5.00 The Journal of Cell Biology, Volume 153, Number 2, April 16, 2001 307318
Determination of Transgenic Loci by Expression FISH Yuhong Fan, Steven A. Braut, Qingcong Lin, Robert H. Singer, and Arthur I. Skoultchi1
The odyssey of a regulated transcript JOSEP VILARDELL,1
Trypanosoma cruzi Infection Affects Actin mRNA Regulation in Heart Muscle Cells
The Rockefeller University Press, 0021-9525/99/10/59/12 $5.00 The Journal of Cell Biology, Volume 147, Number 1, October 4, 1999 5970
Cell, Vol. 97, 515525, May 14, 1999, Copyright 1999 by Cell Press Short Dysfunctional Telomeres Impair
[CANCER RESEARCH 59, 12021205, March 15, 1999] Advances in Brief
One of the most important events in cell differen-tiation and development is the determination of
Cell, Vol. 91, 291294, October 31, 1997, Copyright 1997 by Cell Press Compartmentalization of Minireview
prion propagation. The lysate of 5V-H19 [PSI ] strain was fractionated by centrifuga-
INTRODUCTION Ribonuclease P (RNase P) is a phyletically ubiquitous ribonu-
MOLECULAR AND CELLULAR BIOLOGY, 0270-7306/97/$04.00 0
EXPERIMENTAL CELL RESEARCH 231, 2737 (1997) ARTICLE NO. EX963460
mRNA and cytoskeletal filaments Gary Bassell and Robert H Singer*
str~d synthesis(Fig. 1)"duringreplication.The DNApolymerasethen beginsto`slip'or `stutter'ontherepeat"-`,causingcontinualexpansions.
SequencesResponsible for IntracellularLocalization of -Actin MessengerRNA Also Affect Cell Phenotype
13-ActinmRNA Localization Is Regulated by Signal Transduction Mechanisms
Single mRNAs Visualized by Ultrastructural In Situ Hybridization Are Principally
Neuron, Vol. 12, 571-582, March, 1994, Copyright 0 1994 by Cell Press Association of Poly(A) mRNA
Cell, Vol. 75, 399-401, November 5, 1993, Copyright 0 1993 by Cell Press RNA Travel: Tracks
ROBERT H. SINGER RNA LOCALIZATION RNA zipcodes for cytoplasmic addresses
Determinants of mRNA localization Edward H. Kislauskis and Robert H. Singer
GATA 8(2): 41-58, 1991 IN SITU HYBRIDIZATION
DEVELOPMENTAL BIOLOGY 143,58-67 (1991) Distribution of Myosin Heavy Chain mRNA in Embryonic Muscle Tissue
mission is more efficient when signal-pro-ducing and signal-responsive cells have
Blood, Vol 74, No 6 (November 1), 1989: pp 2295-230 1 2295 Detection of HIV-1-Infected Cells From Patients
sory evoked potential. Neurology 1988,3864-68. 21. YamadaT,KameyamaS,FuchigamiY,NakazumiY,DickinsQS,
Cell, Vol. 52, 51-61, January 15, 1988, Copyright 0 1988 by Cell Press Sensitive, High-Resolution Chromatin and Chromosome
ABBREVIATIONS: AcCh, acetylcholine; a-BgTx, a-bungarotoxin; SOS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis; MBTA, 4-(N-maleimido)benzyltnmethylammonium iodide; Endo F, endoglycosidase F; EDTA, ethylenediaminetetraacetic acid; BSA, bov
Cell, Vol. 45, 407-415, May 9, 1986, Copyright 0 1966 by Cell Press Intracellular Localization of
Volume 13 Nmibef 5 1985 Nucleic Acids Research Quantitative analysis of in situ hybridization methods for the detection of actin gene expression
TISSUE & CELL 1984 16 (1) 17-29 @ 1984 Longman Group Ltd
Vol. 256, No. 12, Issue of June 25, pp. 6408-6412,1980 THEJOURNAL OF BIOLOGICALCHEMISTRY
TISSUE & CELL 1980 12 (4) 5955612 t., 1980 Longman Group Ltd
Electron Microscopic Visualization of the Filamentous Reticulum in Whole Cultured Presumptive
Eur. .I. Biochem. 58,403-410 (1978) The Capacity of Polyadenylated RNA from Myogenic Cells
Eur. J. Biochem. 88, 395-402 (1978) Stability of Polyadenylated RNA in Differentiating Myogenic Cells
Scanning electron microscopic studies of myoblasts from 11-to 13-day-old chick embryonic breast muscle cultured on collagen-coated glass
Proc. Natl. Acad. Sci. uSA Vol. 74, No. 10, pp. 4496-4500, October 1977
J. Mol. Biol. (1973) 78, 321334 Messenger RNA in HeLa Cells : Kinetics of
The Photodynamic Action of Light on Hydra' ROBERT H. SINGER, NORMAN B. RUSHFORTH AND
Immunity, Vol. 20, 337347, March, 2004, Copyright 2004 by Cell Press Structural and Functional Analysis
DNA Repair 8 (2009) 330335 Contents lists available at ScienceDirect
A nucleoporin, Nup60p, affects the nuclear and cytoplasmic localization of ASH1 mRNA
A CBF5 mutation that disrupts nucleolar localization of early tRNA biosynthesis in yeast also suppresses
Translation of ASH1 mRNA is repressed by Puf6pFun12p/eIF5B interaction and
TheJournalofCellBiology The Rockefeller University Press, 0021-9525/2003/01/77/11 $8.00
[CANCER RESEARCH 64, 85858594, December 1, 2004] Identification and Testing of a Gene Expression Signature of Invasive Carcinoma
Biol. Cell (2005) 97, 97110 (Printed in Great Britain) How and why does -actin
THEJOURNALOFCELLBIOLOGY JCB: ARTICLE
Proc. Natl. Acad. Sci. USA Vol. 85, pp. 463-467, January 1988
10.1261/rna.249306Access the most recent version at doi: 2006 12: 2057-2062; originally published online Oct 24, 2006;RNA
MISCELLANEA Robert H. Singer is
Available online at www.sciencedirect.com Modern fluorescent proteins and imaging technologies to study
CD45R (B220; PharMingen, San Diego, CA) [HEL-biotin was prepared with biotinamidocaproate N-hy-
RESEARCH COMMUNICATION Nucleolar localization of early
Imaging Transcription in Living Cells
Developmental Cell A Direct Role for FMRP in Activity-Dependent
Measurement of Barbed Ends, Actin Polymerization, and Motility in Live
Sea Urchin Tube Feet: Unique Structures That Allow a Cytological and Molecular
Proc. Natt Acad. Sci. USA Vol. 79, pp. 7331-7335, December 1982
DEVELOPMENTAL BIOLOGY 28, 113-122 (1972) Analysis of Limb Morphogenesis in a Model System
ANALYTICAL BIOCHEMISTRY 130, l-8 (t983) Analysis of Receptor-Ligand Interactions Using Nitrocellulose
Cell, Vol. 57, 493-502, May 5, 1989, Copyright 0 1999 by Cell Press Highly Localized Tracks of Specific Transcripts
Brief Communication 333 Structural elements required for the localization of ASH1 mRNA
THEJOURNALOFCELLBIOLOGY JCB: ARTICLE
DEVELOPMENTAL BIOLOGY 133,235-246 (1989) Temporal Resolution and Sequential Expression of Muscle-Specific
Actin mRNA Localizes in the Absence of Protein Synthesis C. L. Sundell and R. H. Singer
Calibrating excitation light fluxes for quantitative light microscopy in cell biology
Sorting of -Actin mRNA and Protein to Neurites and Growth Cones in Culture
Ultrastructural Distribution of Poly (A)+ RNA During Trypanosoma cruzi-Cardiomyocyte Interaction in vitro: A Quantitative Analysis of the Total
raphy, radioactivity in gel pieces was determined by scintillation counting. Approximately 1.5 x 108 of
RESEARCH HIGHLIGHTS 126 | VOL.5 NO.2 | FEBRUARY 2008 | NATURE METHODS
Poly(A) RNA Codistribution with Microfilaments: Evaluation by In Situ Hybridization and
Foci of Trinucleotide Repeat Transcripts in Nuclei of Myotonic Dystrophy Cells and Tissues
Supplementary Information for Transcription of functionally related constitutive genes is not
C H A P T E R T W E N T Y -S E V E N Cell Biology of mRNA Decay
29. K. Si, S. Lindquist, E. R. Kandel, Cell 115, 879 (2003). 30. We are indebted to A. Cashikar for expert advice and
4946-4953 Nucleic Acids Research, 1995, Vol. 23, No. 24 1995 Oxford University Press Characterization of hybridization between synthetic
In Situ Reverse Transcription for Detection of Hybridization between Oligonucleotides
Transcription of a gene into its messenger RNA occurs through a series of defined steps, from transcription
[CANCER RESEARCH 62, 60066010, November 1, 2002] Advances in Brief
Pathways for mRNA localization in the Kevin Czaplinski and Robert H. Singer
2004 NaturePublishing Group 856 | OCTOBER 2004 | VOLUME 5 www.nature.com/reviews/molcellbio
Ultrastructural Visualization of Cytoskeletal mRNAs and their Associated Proteins Using Double-Label In Situ Hybridization
J. Membrane Biol. 44, 195-210 (1978) Ca 2+ Binding, ATP-dependent Ca 2+ Transport,
The travels of mRNAs through all cells large and small G. J. BASSELL,*,1
ANALYTICAL BIOCHEMISTRY 166.389-398 (1987) Use of Oligodeoxynucleotide Probes for Quantitative in Situ
Proc. Natl. Acad. Sci. USA Vol. 94, pp. 73887393, July 1997
Seminars in Cell & Developmental Biology 18 (2007) 202208 Imaging mRNA movement from transcription sites to translation sites
Research Reports Krishan L. Taneja
Supplemental Materials for Single RNA counting reveals alternative modes of gene
Journal of Cellular Biochemistry 104:19531963 (2008) Nuclear Microenvironments in Cancer Series
Cellular/Molecular Active Transport of the Survival Motor Neuron Protein and
Research Article 1761 Introduction
The Rockefeller University Press, 0021-9525/2001/11/775/11 $5.00 The Journal of Cell Biology, Volume 155, Number 5, November 26, 2001 775785
Dendritic RNA Transport: Dynamic Spatio-Temporal Control of Neuronal Gene Expression
The Dynamic Range of Transcription Xavier Darzacq1 and Robert H. Singer2,*
Natalia Gromak, Alexis Rideau, Justine Southby, A.D.J.Scadden,
Molecular Biology of the Cell Vol. 19, 41544166, October 2008
Isoform-specific 3'-untranslatedSequences Sort a-cardiac and/3-cytoplasmic ActinMessenger
Molecular Cell YRA1 Autoregulation Requires Nuclear
The cytoskeleton and mRNA localization Robert H. Singer
Cellular/Molecular Localization of a -Actin Messenger Ribonucleoprotein
Imaging of gene expression in living cells and tissues Robert H. Singer
The nucleus has long been known to be functionally and spatially organized. Specific areas have been identified in-
Delft University of Technology, Faculty of Applied Sciences, Kavli Institute of NanoScience, Department of Bionanoscience, 2628 CJ Delft, The Netherlands. 2 Department of Anatomy and Structural
A R T I C L E S Variegated gene expression caused by cell-specific
Cotranscriptional effect of a premature termination codon revealed by live-cell imaging