Ingber, Donald E. - Vascular Biology Program, Harvard University

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Ingber, Donald E. - Vascular Biology Program, Harvard University

17 MARCH 2006 VOL 311 SCIENCE www.sciencemag.org1540 SPACE SCIENCE IS GETTING PLENTY OF
In this issue and systems
A Discrete Cell Cycle Checkpoint in Late G1 That Is Cytoskeleton-Dependent and MAP Kinase (Erk)-Independent
CANCER CELL : SEPTEMBER 2005 175 Clinicians often diagnose tumors based
ANGIOPOIETIN-1 REQUIRES P190RHOGAP TO PROTECT AGAINST VASCULAR LEAKAGE IN VIVO
Development/Plasticity/Repair Synaptic Reorganization in Scaled Networks of
The Mechanochemical Basis of Cell and Tissue Regulation
This article was originally published in a journal published by Elsevier, and the attached copy is provided by Elsevier for the
Novel dynamic rheological behavior of individual focal adhesions measured within single cells using
The Shedding of Membrane-anchored Heparin-binding Epidermal-like Growth Factor Is Regulated by the
Mechanical forces influence the growth and shape of virtually every tissue and organ in
Patterned deposition of cells and proteins onto surfaces by using three-dimensional
Author Correction Estrogen-receptor-exchange and chromatin dynamics are ligand-and
Cell Fates as High-Dimensional Attractor States of a Complex Gene Regulatory Network Sui Huang,1,* Gabriel Eichler,1
Introduction Cellular biochemistry plays out in a world of structural
Modulation of Adhesion-Dependent cAMP Signaling by Echistatin and Alendronate
Selective Deposition of Proteins and Cells in Arrays of Emanuele Ostuni, Christopher S. Chen,, Donald E. Ingber, and
EXPERIMENTAL CELL RESEARCH 235, 305313 (1997) ARTICLE NO. EX973668
In Vitro Cell. Dev. Biol.--Animal 36:563565, October 2000 2000 Society for In Vitro Biology
Molecular Biology of the Cell Vol. 9, 31793193, November 1998
development of the single molecule technology and sci-Pollack views this image as a dragon that must be slain and I cannot agree more.ence in general.
DNA Topoisomerase II Can Drive Changes in Higher Order Chromosome Architecture Without
At 9 A.M. on a hot, sticky Friday in the middle of June, the tiny
Introduction Biology and medicine are currently undergoing a paradigm
Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering
EXPERIMENTAL CELL RESEARCH 231, 1426 (1997) ARTICLE NO. EX963451
Mechanical Continuity and Reversible Chromosome Disassembly Within Intact Genomes Removed
Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional
How cells (might) sense microgravity DONALD INGBER1
Mechanical Control of cAMP Signaling Through Integrins Is Mediated by the Heterotrimeric Gas Protein
Intracellular stress tomography reveals stress focusing and structural anisotropy in cytoskeleton of living cells
DEVELOPMENT What lies at the interface of
INTRODUCTION Many specialized cells, such as hepatocytes, can be switched
Nature Macmillan Publishers Ltd 1998 letters to nature
Transcriptome-wide noise controls lineage choice in mammalian progenitor cells
Micromechanical control of cell and tissue development: Implications for tissue engineering
THEJOURNALOFCELLBIOLOGY JCB: CORRECTION
Global cytoskeletal control of mechanotransduction in kidney epithelial cells
[8] T. Miteva, A. Meisel, H. Nothofer, U. Scherf, W. Knoll, D. Neher, M. Grell, D. Lupo, A. Yasuda, Synth. Met. 2000, 111112, 173.
Progress in Biophysics and Molecular Biology ] (]]]]) ]]]]]] Tensegrity-based mechanosensing from macro to micro
controversies in physiology Opposing views on tensegrity as a structural framework
Copyright c 2005 Tech Science Press MCB, vol.2, no.3, pp.135-143, 2005 Control of the Direction of Lamellipodia Extension through Changes in the
RESEARCH/RESEARCHERS 786 MRS BULLETIN/NOVEMBER 2004
J. theor. Biol. (1996) 181, 125136 00225193/96/140125 + 12 $18.00/0 7 1996 Academic Press Limited
Control of Embryonic Lung Branching Morphogenesis by the Rho Activator, Cytotoxic Necrotizing Factor 1
Extracellular matrix and pulmonary hypertension: control of vascular smooth muscle cell contractility
456 Research Article Introduction
Electromagnetic needles with submicron pole tip radii for nanomanipulation of biomolecules and living cells
EXPERIMENTAL CELL RESEARCH 224, 116122 (1996) ARTICLE NO. 0118
The FASEB Journal Review Cellular mechanotransduction: putting all the pieces
CELLS AS TENSEGRITY STRUCTURES: ARCHITECTURAL REGULATION OF HISTODIFFERENTIATION BY
Controlling Mammalian Cell Spreading and Cytoskeletal Arrangement with Conveniently Fabricated Continuous
www.stke.org/cgi/content/full/OC_sigtrans;2002/119/pe6 Page 1 Mechanotransduction is cellular signal transduction in response
www.softmatter.org SamuelI.Stuppetal.
C H A P T E R T W E L V E Methods for Studying Mechanical
Noise-driven stem cell and progenitor population dynamics
Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal
This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
Please cite this article in press as: Ingber DE, Can cancer be reversed by engineering the tumor microenvironment?, Seminars in Cancer Biology (2008), doi:10.1016/j.semcancer.2008.03.016
From Molecular Cell Engineering to Biologically Inspired Engineering DONALD E. INGBER
Investigating complexity of proteinprotein interactions in focal adhesions Tanmay P. Lele a,1
2007 Nature Publishing Group Nanomagnetic actuation of receptor-
International Journal of Modern Physics C Vol. 18, No. 9 (2007) 14591473
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet
-Actinin-4 Is Required for Normal Podocyte Adhesion*S Received for publication,May 25, 2006, and in revised form, October 24, 2006 Published, JBC Papers in Press,November 2, 2006, DOI 10.1074/jbc.M605024200
Mechanical Stimuli to Cells CHAPTER 19
Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology
Tissue Engineering and Developmental Biology: Going Biomimetic
Magnetically-Guided Self-Assembly of Fibrin Matrices with Ordered Nano-Scale Structure for Tissue Engineering
Biomed Microdevices (2006) 8:299308 DOI 10.1007/s10544-006-0033-0
Journal of Cellular Biochemistry 99:13341342 (2006) Methods for Measuring Rates of Protein
Loss of Polycystin-1 in Human Cyst-Lining Epithelia Leads to Ciliary Dysfunction
ARTICLE IN PRESS A mathematical model to determine molecular kinetic rate constants
JOURNAL OF CELLULAR PHYSIOLOGY 207:187194 (2006) Mechanical Forces Alter Zyxin Unbinding Kinetics
Integrins 1, 6, and 3 contribute to mechanical strain-induced differentiation of fetal lung type II epithelial cells via distinct mechanisms
508 Research Article Introduction
Journal of Cellular Biochemistry 97:11751183 (2006) Force Meets Chemistry: Analysis of Mechanochemical
Evidence by molecular profiling for a placental origin of infantile hemangioma
THEJOURNALOFCELLBIOLOGY The Rockefeller University Press $8.00
Mechanical control of tissue growth: Function follows form
Symmetry-Breaking in Mammalian Cell Cohort Migration During Tissue Pattern
Vacuum-Assisted Closure: Microdeformations of Wounds and Cell Proliferation
Copyright c 2004 Tech Science Press MCB, vol.1, no.3, pp.181-190, 2004 An Improved Mathematical Approach for Determination of Molecular Kinetics in
Role of RhoA, mDia, and ROCK in Cell Shape-dependent Control of the Skp2-p27kip1
Mechanobiology and diseases of mechanotransduction
BIOINFORMATICS APPLICATIONS NOTE Vol. 19 no. 17 2003, pages 23212322
BioMed Central Page 1 of 10
Models of cytoskeletal mechanics of adherent cells D. Stamenovic, D. E. Ingber
Geometric Determinants of Directional Cell Motility Revealed Using Microcontact Printing
Differentiation (2002) 70:547560 C Blackwell Verlag 2002 Donald E. Ingber
Ann. N.Y. Acad. Sci. 961: 162163 (2002). 2002 New York Academy of Sciences. Mechanical Signaling
Ann. N.Y. Acad. Sci. 961: 164167 (2002). 2002 New York Academy of Sciences. Molecular Signaling
Micropatterning Tractional Forces in Living Cells
Intact Vinculin Protein Is Required for Control of Cell Shape, Cell Mechanics, and rac-Dependent
Molecular Biology of the Cell Vol. 12, 30873094, October 2001
Laminarflows Subcellular positioning
The origin of cellular life Donald E. Ingber
Patterning Mammalian Cells Using Elastomeric Emanuele Ostuni, Ravi Kane, Christopher S. Chen, Donald E. Ingber, and
1999 Macmillan Magazines Ltd NATURE CELL BIOLOGY | VOL 1 | SEPTEMBER 1999 | cellbio.nature.com E131
Biomaterials 20 (1999) 2363}2376 Patterning proteins and cells using soft lithography
New Role for tRNA and Its Fragment Purified From Human Urinary Bladder Carcinoma Conditioned
In Search of Cellular Control: Signal Transduction Donald Ingber*
Cellular control lies in the balance of forces Marina E Chicurel, Christopher S Chen and Donald E Ingber*
Reference: Biol. Bull. 194: 323-327. (June, 1998) Cellular Basis of Mechanotransduction
Ionic Control of Chromosome Architecture in Living and Permeabilized Cells
INTRODUCTION Vimentin is the major structural component of intermediate
INTRODUCTION Extracellular matrix (ECM) is critical for regulation of cell
Proc. Natl. Acad. Sci. USA Vol. 94, pp. 849854, February 1997
INTRODUCTION Angiogenesis, the growth of new blood vessels, is stimulated
Leukocyte Adhesion to Vascular Endothelium Induces E-Selectin Linkage to the Actin Cytoskeleton
Adhesion to Fibronectin Stimulates Inositol Lipid Synthesis and Enhances PDGF-induced Inositol Lipid Breakdown
"...organization exists in the living organism, and this organ -ization is not something fundamentally mystical and una -
Introduction One of the most fundamental problems in tissue morpho-
Control of Intracellular pH and Growthby Fibronectin in Capillary Endothelial Cells
Gene Expression Dynamics Inspector v2.1 User Manual -Overview
Gene Expression Dynamics Inspector v2.1 Below is a detailed description of each of the parameters that can be changed in the "Change
GEDI -Summary of Procedure Experimental Setup
Caldesmon-dependent switching between capillary endothelial cell growth and apoptosis through modulation of cell shape and contractility
Mechanical control of tissue morphogenesis during embryological development
Life is the ultimate example of complexity at work. An organism, whether it is a bacterium or a baboon, de-
2005 Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology 2005:2 (2005) 96103 DOI: 10.1155/JBB.2005.96
BioMed Central Page 1 of 12
Analysis of Cell Mechanics in Single Vinculin-Deficient Cells Using a Magnetic Tweezer
INTRODUCTION Angiogenesis, the growth of new capillary blood vessels,
Gene Expression Dynamics Inspector v2.1 Input Data Format
Cell shape provides global control of focal adhesion assembly Christopher S. Chen,a
Copyright c 2004 Tech Science Press MCB, vol.1, no.1, pp.53-68, 2004 The Mechanochemical Basis of Cell and Tissue Regulation
Pulse energy dependence of subcellular dissection by femtosecond laser pulses
13 April 2005 HO EM | EWSN PRINT EDITION
This Review is part of a thematic series on Integrins, which includes the following articles: Integrins and the Myocardium
Tissue adaptation to mechanical forces in healthy, injured and aging tissues
Shape-Dependent Control of Cell Growth, Differentiation, and Apoptosis: Switching between Attractors in Cell Regulatory Networks
Regulation of cytoskeletal mechanics and cell growth by myosin light chain phosphorylation
Breast Disease 26 (2006,2007) 2754 27 A Non-Genetic Basis for Cancer Progression
Mechanical properties of individual focal adhesions probed with a magnetic microneedle
Mechanosensation through integrins: Cells act locally but think globally
Extracellular matrix controls myosin light chain phosphorylation and cell contractility through modulation of cell shape and cytoskeletal prestress
RESEARCH ARTICLE Control of Basement Membrane Remodeling
Annals of Biomedical Engineering, Vol. 32, No. 4, April 2004 (2004) pp. 520530 A Computational Tensegrity Model Predicts Dynamic Rheological
2000 Macmillan Magazines Ltd brief communications
Apoptosis of Syncytia Induced by the HIV-1Envelope Glycoprotein Complex: Influence of Cell Shape and Size
Copyright c 2005 Tech Science Press MCB, vol.2, no.1, pp.17-25, 2005 Ablation of cytoskeletal filaments and mitochondria in live cells using a
0013-7227/86/1194-1768$02.00/0 Endocrinology
ORIGINAL ARTICLES Tensile Forces Stimulate Vascular Remodeling
This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
Viscoelastic Retraction of Single Living Stress Fibers and Its Impact on Cell Shape, Cytoskeletal Organization, and Extracellular Matrix Mechanics
C.CHEN&D.INGBER he lecturer flattened a tangle of sticks
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