Liu, David R. - Department of Chemistry and Chemical Biology, Harvard University

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Liu, David R. - Department of Chemistry and Chemical Biology, Harvard University

Mammalian Cell Penetration, siRNA Transfection, and DNA Transfection by Supercharged Proteins
Synthesis of Acyclic r, -Unsaturated Ketones via Pd(II)-Catalyzed Intermolecular Reaction of Alkynamides and Alkenes
Effects of Template Sequence and Secondary Structure on DNA-Templated Reactivity
Supporting Information Efficient and Sequence-Specific DNA-Templated Polymerization of PNA Aldehydes
LC/MS analysis of cellular RNA reveals NAD-linked RNA Y. Grace Chen
Control of Transcription Factor Activity and Osteoblast Differentiation in Mammalian Cells Using an Evolved
Mammalian cell penetration, siRNA transfection, and DNA transfection by supercharged proteins
Directed evolution of protein enzymes using nonhomologous random recombination
B R I E F COM M U N I CAT I O N S The known chemical diversity of natural RNA has remained lim-
Supplementary Information An In Vitro Translation, Selection, and Amplification System for Peptide Nucleic Acids
Solving chemical problems through the application of evolutionary principles
Kanan, Liu et al. Supplementary Information page 1 "Reaction Discovery Enabled by DNA-Templated Synthesis and
Translation of DNA into a Library of 13 000 Synthetic Small-Molecule Macrocycles Suitable for in Vitro Selection
10 SEPTEMBER 2004 VOL 305 SCIENCE www.sciencemag.org1558 CREDIT:K.BUCKHEIT/SCIENCE
Supporting Information Effects of Template Sequence and Secondary Structure on DNA-Templated Reactivity
March, 2006 Liu Group Research Summary page 1 EVOLUTIONARY PRINCIPLES APPLIED TO THE DISCOVERY AND STUDY OF FUNCTIONAL
A Chemical Screen for Biological Small Molecule-RNA Conjugates Reveals CoA-Modified RNA
Supporting Information DNA-Templated Polymerization of Side-Chain-Functionalized Peptide Nucleic Acid
Binding and Stability Determinants of the PPAR Nuclear Receptor-Coactivator Interface As Revealed by Shotgun
The Generality of DNA-Templated Synthesis as a Basis for Evolving Non-Natural Small Molecules
COMMUNICATIONS 1796 WILEY-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002 1433-7851/02/4110-1796 $ 20.00+.50/0 Angew. Chem. Int. Ed. 2002, 41, No. 10
Multistep Small-Molecule Synthesis Programmed by DNA Templates Zev J. Gartner, Matthew W. Kanan, and David R. Liu*
Gartner, Kanan, Liu Supporting Information page 1 Supporting Information
Directing Otherwise Incompatible Reactions in a Single Solution by Using DNA-Templated
DNA-Templated Synthesis Two Enabling Architectures for DNA-Templated
Supporting Information Highly Sensitive In Vitro Selections for DNA-Linked Synthetic Small Molecules
Efficient and Sequence-Specific DNA-Templated Polymerization of Peptide Nucleic Acid Aldehydes
Synthetic Methods DNA-Templated Organic Synthesis: Natures Strategy
Gartner et al. Supporting Online Material page 1 Supporting Online Material
RESEARCH HIGHLIGHTS 6 | VOL.1 NO.1 | OCTOBER 2004 | NATURE METHODS
Reaction discovery enabled by DNA-templated synthesis and
Nucleic-acid-templated synthesis as a model system for ancient translation
In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase
In Vitro Characterization of Salmochelin and Enterobactin Trilactone Hydrolases IroD, IroE, and Fes
Supporting Information Wiley-VCH 2005
ron is essential for growth in nearly all bacteria. In microenvironments where
Bromoenterobactins as Potent Inhibitors of a Pathogen-Associated, Siderophore-Modifying C-Glycosyltransferase
Chemistry & Biology In Vivo Evolution of an RNA-Based Transcriptional
NATURE METHODS | VOL.4 NO.4 | APRIL 2007 | 297 RESEARCH HIGHLIGHTS
Supercharging Proteins Can Impart Unusual Resilience Michael S. Lawrence, Kevin J. Phillips, and David R. Liu*
NATURE METHODS | VOL.4 NO.12 | DECEMBER 2007 | 995 Dissecting protein structure and function using
Development and Initial Application of a Hybridization-Independent, DNA-Encoded Reaction Discovery
A chemical screen for biological small moleculeRNA conjugates reveals CoA-linked RNA
DOI: 10.1126/science.1170116 , 930 (2009);324Science
Templated Synthesis of Peptide Nucleic Acids via Sequence-Selective Base-Filling Reactions
Cell Stem Cell A Small-Molecule Inhibitor of Tgf-b Signaling
nature chemical biology | VOL 6 | JUNE 2010 | www.nature.com/naturechemicalbiology 387 special feature
The Behaviour of 5-Hydroxymethylcytosine in Bisulfite Yun Huang1.
In Vitro Selection of a DNA-Templated Small-Molecule Library Reveals a Class of Macrocyclic Kinase Inhibitors
research highlights 952 | VOL.7 NO.12 | DECEMBER 2010 | nature methods
Supporting Information Interaction-Dependent PCR: Identification of Ligand-Target Pairs from Libraries of
SUPPLEMENTARY INFORMATION doi: 10.1038/nchem.932
Directed evolution of ligand dependence: Small-molecule-activated protein splicing
Combinatorial Chemistry DOI: 10.1002/anie.200502899
Synthetic Methods DOI: 10.1002/anie.200502879
have significant implications in areas where charge transport in nanostructured materials
67506761 Nucleic Acids Research, 2007, Vol. 35, No. 20 Published online 4 October 2007 doi:10.1093/nar/gkm777
Localized Protein Interaction Surfaces on the EntB Carrier Protein Revealed by Combinatorial Mutagenesis and Selection
148 nature chemical biology | vol 6 | february 2010 | www.nature.com/naturechemicalbiology published online: 27 december 2009 | doi: 10.1038/nchembio.280
DNA-Templated Polymerization of Side-Chain-Functionalized Peptide Nucleic Acid Aldehydes
Angew. Chem. Int. Ed. 2002, 41, No. 1 WILEY-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002 1433-7851/02/4101-0089 $ 17.50+.50/0 89 DNA-Templated Synthesis: More Versatile than Expected
Interaction-Dependent PCR: Identification of Ligand-Target Pairs from Libraries of Ligands and Libraries of Targets in a Single Solution-Phase
Highly Sensitive in Vitro Selections for DNA-Linked Synthetic Small Molecules with Protein Binding Affinity and Specificity
Momiyama, Kanan, Liu page S1 Synthesis of Acyclic !,"-Unsaturated Ketones via Pd(II)-Catalyzed
Potent Delivery of Functional Proteins into Mammalian Cells in Vitro and in Vivo Using a
Ruff, Snyder, Liu Supporting Information S1 Enhanced Functional Potential of Nucleic Acid Aptamer Libraries Patterned to Increase
2010 Liu Group Research Summary page 1 CHEMICAL AND BIOLOGICAL DISCOVERY DRIVEN BY THE PRINCIPLES OF EVOLUTION
A biomolecule-compatible visible-light-induced azide reduction from a DNA-encoded
PALAEONTOLOGY Climateforchange
Directed Evolution and Substrate Specificity Profile of Homing Endonuclease I-SceI
The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2
Supplemental protocol for "Mammalian cell penetration, siRNA transfection, and DNA transfection by supercharged proteins" (McNaughton, Cronican, Thompson,
Stereoselectivity in DNA-Templated Organic Synthesis and Its Origins Xiaoyu Li and David R. Liu*
Photoswitching Mechanism of Cyanine Dyes Graham T. Dempsey,
Supporting Information Wiley-VCH 2005
DNA-Templated Functional Group Transformations Enable Sequence-Programmed Synthesis Using Small-Molecule Reagents
Translation of DNA into Synthetic N-Acyloxazolidines Xiaoyu Li, Zev J. Gartner, Brian N. Tse, and David R. Liu*
Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes
Supporting Information for Gartner and Liu Manuscript DNA synthesis. DNA oligonucleotides were synthesized on a PerSeptive Biosystems Expedite
Vice leaves little to chance DNA aids chemical synthesis by bringing molecules closer together.
Reactivity-Dependent PCR: Direct, Solution-Phase in Vitro Selection for Bond David J. Gorin, Adam S. Kamlet, and David R. Liu*
Chemistry & Biology Recent Progress Toward the Templated Synthesis
Published online 24 July 2007 Nucleic Acids Research, 2007, Vol. 35, No. 17 58515860 doi:10.1093/nar/gkm634
Molecular evolution allows chemists and biologists to generate nucleic acids with tailor-made binding or catalytic activities.
Supporting Information DNA-Templated Functional Group Transformations Enable Sequence-
Optical imaging through scattering media via magnetically modulated fluorescence
Supporting Information for Lawrence, Phillips, and Liu Materials and Methods
Tse et al. Supporting Information page S1 Translation of DNA into a Library of 13,000 Synthetic Small-Molecule
328 ACS CHEMICAL BIOLOGY VOL.1 NO.6 www.acschemicalbiology.org Published online July 21, 2006 10.1021/cb600287r CCC: $33.50
DOI: 10.1002/cbic.200500413 DNA-Templated Synthesis in Organic
Rozenman et al. Supporting Information page 1 A Hybridization-Independent, DNA-Encoded Reaction Discovery System Reveals a
Supplemental Data Functional Dissection of sRNA Translational
A protein interaction surface in nonribosomal peptide synthesis mapped by combinatorial
www.sciencemag.org/cgi/content/full/1170116/DC1 Supporting Online Material for
Translation of DNA into Synthetic N-Acyloxazolidines Xiaoyu Li, Zev. J. Gartner, Brian N. Tse and David R. Liu*
biological roles of chemically modified RNAs in cells. To explore this landscape further,
Autonomous multistep organic synthesis in a single isothermal solution mediated
Enhanced Functional Potential of Nucleic Acid Aptamer Libraries Patterned to Increase Secondary Structure
Chemistry & Biology Brief Communication
Published: June 09, 2011 r 2011 American Chemical Society 9972 dx.doi.org/10.1021/ja201361t |J. Am. Chem. Soc. 2011, 133, 99729975
Molecular Cell A De Novo Protein Binding Pair
This journal is c The Royal Society of Chemistry 2011 Chem. Soc. Rev. Cite this: DOI: 10.1039/c1cs15076f
Chemistry & Biology Directed Evolution of a Small-Molecule-Triggered
LETTER doi:10.1038/nature09929 A system for the continuous directed evolution of
A R T I C L E S Opposing effects of Tcf3 and Tcf1 control Wnt
A general strategy for the evolution of bond-forming enzymes using yeast display
2011NatureAmerica,Inc.Allrightsreserved. nAture methods | ADVANCEONLINEPUBLICATION |
Inhibition of Bacterial Conjugation by Phage M13 and Its Protein g3p: Quantitative Analysis and Model
Published: October 18, 2011 r 2011 American Chemical Society 4859 dx.doi.org/10.1021/nl203194m |Nano Lett. 2011, 11, 48594864
C H A P T E R T W E L V E Engineering and Identifying