Crews, Craig M. - Department of Molecular Biophysics and Biochemistry, Yale University

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Crews, Craig M. - Department of Molecular Biophysics and Biochemistry, Yale University

SHORT COMMUNICATION DOI: 10.1002/ejoc.200600721
which case some of the symptoms could reflect molybdenum insufficiency. Finally,
Bioorganic& MedicinalChemistryLetters 9 (1999) 2283-2288 BIOORGAN1C &
The Ubiquitin-Proteasome Pathway and Proteasome Inhibitors
Triptolide-Induced Transcriptional Arrest Is Associated with Changes in Nuclear Substructure
Unexpected stereochemical tolerance for the biological activity of tyroscherin Hyun Seop Tae a
Chemical Inducers of Targeted Protein Degradation*
The antiangiogenic agent TNP-470 requires p53 and for endothelial cell growth arrest
MOLECULAR AND CELLULAR BIOLOGY, Sept. 1989, p. 3850-3859 Vol. 9, No. 9 0270-7306/89/093850-10$02.00/0
Chemical Genetics: Exploring the Role of the Proteasome in Cell Biology Using Natural Products and Other Small Molecule Proteasome Inhibitors
Chemical Genetic Control of Protein Levels: Selective in Vivo Targeted Degradation
Reversal of TNP-470-Induced Endothelial Cell Growth Arrest by Guanine and Guanine Nucleosides
TETRAHEDRON Tetrahedron Letters 41 (2000) 96399643Pergamon
Proc. Natl. Acad. Sci. USA Vol. 96, pp. 1040310408, August 1999
Wound epidermis formation and function in urodele amphibian limb regeneration
A Single Amino Acid Residue Defines the Difference in Ovalicin Sensitivity between Type I and II Methionine Aminopeptidases*S
Activation of the planar cell polarity formin DAAM1 leads to inhibition of endothelial cell proliferation,
Communication Vol. 269, No. 22, Issue of June 3, pp. 15411-15414, 1994 THE JOURNALOF BIOLOGICALCHEMISTRY
ORIGINAL PAPER A role for planar cell polarity signaling in angiogenesis
Development of Protacs to Target Cancer-promoting Proteins for
Cell, Vol. 74, 215-217, July 30, 1993, Copyright 0 1993 by Cell Press Extracettutar Signals
Total Synthesis and Biological Evaluation of Tyroscherin
Protacs: Chimeric molecules that target proteins to the Skp1CullinF box complex for ubiquitination
Neurotrophic peptide aldehydes: Solid phase synthesis of fellutamide B and a simplified analog
[CANCER RESEARCH 59, 27982801, June 15, 1999] Advances in Brief
TETRAHEDRON Pergamon Tetrahedron Letters 39 (1998) 779-782
Total Synthesis and Structure-Activity Investigation of the Marine Natural Product Neopeltolide
ORIGINAL ARTICLE Targeting steroid hormone receptors for ubiquitination and degradation in
Proc. Natl. Acad. Sci. USA Vol. 94, pp. 60996103, June 1997
Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic
Synthesis of the C3-C18 Fragment of Amphidinolides G and H
r XXXX American Chemical Society A dx.doi.org/10.1021/ja109377p |J. Am. Chem. Soc. XXXX, XXX, 000000 COMMUNICATION
Targeting Cyst Initiation in Stephanie J. Leuenroth* and Craig M. Crews*
INTRODUCTION Dividing cells are regularly faced with the prodi-
Eponemycin Analogues: Syntheses and use as Probes of Angiogenesis
Chemistry & Biology Targeting the Undruggable Proteome
Nephrol Dial Transplant (2010) 1 of 8 doi: 10.1093/ndt/gfp777
DOI: 10.1002/cbic.200900547 Identification and Characterization of a Peptidic Ligand for
Subscriber access provided by YALE UNIV ACS Chemical Biology is published by the American Chemical Society. 1155
Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics
Triptolide Reduces Cystogenesis in a Model of ADPKD Stephanie J. Leuenroth,* Natasha Bencivenga,* Peter Igarashi,
Leading Edge Cell 130, September 7, 2007 2007 Elsevier Inc. 769
Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease
Myriaporone 3/4 structureactivity relationship studies define a pharmacophore targeting eukaryotic protein synthesis{
Synthetic Studies on Amphidinolide B1 Amit K. Mandal, John S. Schneekloth, Jr., Kouji Kuramochi, and
Stereoselective Assembly of a 1,3-Diene via Coupling between an Allenic Acetate
Developing microcolin A analogs as biological probes Amit K. Mandal,a
Sokol, S., Christian, J. L., Moon, R. T., and Melton, D. A. (1991). Injected Wnt RNA induces a complete body axis in Xenopus embryos. Cell 67, 741752.
Chemical Approaches to Controlling Intracellular Protein Degradation
Total Synthesis of TMC-95A and -B via a New Reaction Leading to Z-Enamides. Some Preliminary Findings as to SAR
Feeding the machine: mechanisms of proteasome-catalyzed degradation of ubiquitinated proteins
Introduction The mechanisms by which bone formation is regulated
508 2003 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim DOI: 10.1002/cbic.200300560 ChemBioChem 2003, 4, 508 513 Simplified Synthetic TMC-95A/B Analogues
Developmental Cell, Vol. 5, 1119, July, 2003, Copyright 2003 by Cell Press ReviewChemical Genetics: Adding to the
Neuron, Vol. 36, 563566, November 14, 2002, Copyright 2002 by Cell Press MinireviewChemical Genetics: A Small
Inhibitors of NF-B Signaling: Design and Synthesis of a Biotinylated Isopanepoxydone Affinity Reagent
Total Synthesis of Luminacin D J. Brad Shotwell,, Evan S. Krygowski, John Hines, Brian Koh,
Characterization of a Novel Mammalian Phosphatase Having Sequence Similarity to Schizosaccharomyces pombe PHO2 and Saccharomyces cereVisiae PHO13
Research Paper The anti-inammatory natural product parthenolide from the
Molecular Cell, Vol. 7, 411420, February, 2001, Copyright 2001 by Cell Press Lack of Proteasome Active Site Allostery
Cells adapted to the proteasome inhibitor 4-hydroxy-5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl
Crystal Structure of Epoxomicin:20S Proteasome Reveals a Molecular Basis for Selectivity of
The cell cycle remains an attractive target for the development of small-molecule inhibitors for use as both novel
BIOORGANIC & MEDICINAL CHEMISTRY
Towards subunit-specific proteasome inhibitors: synthesis and evaluation of peptide ,-epoxyketones
The Antiproliferative Agent Didemnin B Uncompetitively Inhibits Palmitoyl Protein Thioesterase
Proc. Natl. Acad. Sci. USA Vol. 93, pp. 43164319, April 1996
MOLECULAR AND CELLULAR BIOLOGY, Nov. 1993, p. 6615-6620 0270-7306/93/116615-06$02.00/0
Chemistry & Biology Proteasome Inhibition by Fellutamide B Induces
Chemistry & Biology Disruption of Wnt Planar Cell Polarity Signaling