Myers, Andrew G.- Department of Chemistry and Chemical Biology, Harvard University

• Development of an Enantioselective Synthetic Route to Neocarzinostatin Chromophore and Its Use for Multiple
• Greatly Simplified Procedures for the Synthesis of r-Amino Acids by the Direct Alkylation of Pseudoephedrine Glycinamide Hydrate
• 1670 J. Am. Chem. SOC.1994,116, 1670-1682 DNA Cleavage by Neocarzinostatin Chromophore.
• Method for the Rapid Synthesis of Highly Functionalized
• An enantioselective, modular, and general route to the cytochalasins: Synthesis of L-696,474 and
• 9672 J. Am. Chem. SOC.1990, 112, 9672-9674 Table 1. Yield and I9F Nuclear Magnetic Resonance Data of Epoxy Acid
• Chemistry & Biology, Vol. 9, 607618, May, 2002, 2002 Elsevier Science Ltd. All rights reserved. PII S1074-5521(02)00137-0 Transcriptional Response Pathways in a Yeast Strain
• 1622 C17HIsN205 The present crystal structure analysis shows that
• J. Am. Chem. SOC.1991, 113, 9661-9663 9661 "(a) Allyl iodide (1.2 equiv), Bu4NHS04 (1.2equiv), LiOH (50
• A Method for the Preparation of Differentiated trans-1,2-Diol Derivatives with Enantio-and Diastereocontrol
• Stereocontrolled Alkylative Construction of Quaternary Carbon Centers David A. Kummer, William J. Chain, Marvin R. Morales, Olga Quiroga, and Andrew G. Myers*
• The Natural Product Avrainvillamide Binds to the Oncoprotein Nucleophosmin
• Synthesis of (-)-Tetracycline Mark G. Charest, Dionicio R. Siegel, and Andrew G. Myers*
• Efficient, Stereoselective Synthesis of trans-2,5-Disubstituted Morpholines
• Heck-Type Arylation of 2-Cycloalken-1-ones with Arylpalladium
• Identification of GAPDH as a protein target of the saframycin antiproliferative agents
• Development of a Decarboxylative Palladation Reaction and Its Use in a Heck-type Olefination of Arene Carboxylates
• Evidence for Facile Atropisomerism and Simple (Non-Nucleophilic) Biradical-Forming Cycloaromatization within Kedarcidin Chromophore
• COMMUNICATIONS 1062 WILEY-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002 1433-7851/02/4106-1062 $ 17.50+.50/0 Angew. Chem. Int. Ed. 2002, 41, No. 6
• Gene transcription analysis of Saccharomyces cerevisiae exposed to neocarzinostatin protein
• Synthesis of a Broad Array of Highly Functionalized, Enantiomerically Pure
• Synthesis of C-Protected r-Amino Aldehydes of High Enantiomeric Excess
• Observations Concerning the Existence and Reactivity of Free r-Amino Aldehydes as Chemical
• Pergamon Tetrahedron Letters 41 (2000) 13591362 TETRAHEDRON
• Communications to the Editor A Concise, Stereocontrolled Synthesis of
• Preparation of Chiral, C-Protected r-Amino Aldehydes of High Optical Purity and Their Use as
• Total Synthesis of (+)-Neocarzinostatin Chromophore
• Single-Step Process for the Reductive Deoxygenation of Unhindered Alcohols
• Pseudoephedrine as a Practical Chiral Auxiliary for the Synthesis of Highly Enantiomerically Enriched Carboxylic
• Enzymatic Activation of DNA Cleavage by Dynemicin A and Synthetic Analogs Andrew G. Myers,* Michael E. Kort, Scott B. Cohen, and Norma J. Tom
• A Comparison of DNA Cleavage by Neocarzinostatin Chromophore and Its Aglycon: Evaluating the Role of the
• Enantioselective Synthesis of Neocarzinostatin Chromophore Aglycon
• A New and Unusual Pathway for the Reaction of Neocarzinostatin Chromophore with Thiols.
• 8488 J. Am. Chem. SOC.1995,117, 8488-8489 A Practical Method for the Synthesis of D-or
• Synthesis of (+)-dynemicin A and analogs of wide structural variability: establishment of the
• 11556 J. Am. Chem. SOC.1994,116, 11556-11557 Highly Convergent Route to Dynemicins of Wide
• J. Am. Chem. SOC.1994,116, 9361-9362 9361 Use of Pseudoephedrine as a Practical Chiral Auxiliary
• J. Am. Chem. SOC.1994, 116, 4691-4118 4691 Synthetic Studies of the Tunicamycin Antibiotics. Preparation
• J. Am. Chem. SOC.1994,116, 1255-1291 1255 A Study of the Reaction of Calicheamicin y1 with Glutathione
• 7926 J. Am. Chem. SOC.1993,115, 7926-7927 Synthesisof (f)-7,8-Epoxy-4-basmen-6-oneby a
• J. Am. Chem. SOC.1993,115,7021-7022 7021 A Reaction Cascade Leading to
• REGULAR STRUCTURAL PAPERS 185 Refinement on F
• 10986 J. Am. Chem. SOC.1992,114, 10986-10987 Synthesis of 1,6-Didehydro[lO]a~ulene. Observationof
• J. Am. Chem. SOC.1992, 114, 5859-5860 Communications to the Editor
• J. Am. Chem. SOC.1992, 114, 2765-2767 2765 the resulting C(12) hydroxylwas reprotected as a methoxymethyl
• 2090 REGULAR STRUCTURAL PAPERS Lists of structure factors, anisotropic thermal parameters, H-atom coor-
• 1086 J. Am. Chem. SOC. tensively pursued and will be described in due course.
• 2578 C17H25NO3 Si Final parameters are given in Table 1" for isomers
• 694 J. Am. Chem. SOC.1991, 113,694-695 C 0 2and CO byproducts, has a dramatic hindering effect on the
• 8208 J . Am. Chem. SOC.1990, 112, 8208-8210 progress to further elucidate this mechanism by varying the
• 9130 J. Am. Chem. SOC.1989, 111, 9130-9132 in determining the ground-state metrical parameters of the un-
• 1146 J. Am. Chem. SOC.1989, 111, 1146-1 147 Evidence for Spontaneous, Low-Temperature Biradical
• Tetrahedron Letters,Vo1.27,No.42,pp 5083-5084,1986 0040-4039/86 $3.00 + .OO Printed in Great Britain Pergamon Journals Ltd.
• 5574 J. Am. Chem. SOC. Total Synthesis of (f)-Antheridium-Inducing Factor
• J.Org. Chem. 1981,46, 1509-1511 1509 Antibiotic X-14547A: Total Synthesis of the
• Asymmetric Synthesis of Chiral Organofluorine Compounds: Use of Nonracemic Fluoroiodoacetic Acid as a Practical Electrophile and Its
• J. Am. Chem. SOC.1989, 111, 8057-8059 8057 = 140 M-I) to 9-ethyladenine (3) in THF-d8.13 For comparison,
• Practical Procedures for the Preparation of N-tert-Butyldimethylsilylhydrazones and Their Use in Modified
• Practical Syntheses of Enantiomerically Enriched -Lactones and -Hydroxy Ketones by the Alkylation of Pseudoephedrine Amides
• Tetrahedron Letters,Vol.29,No.49,pp 6389-6392,1988 0040-4039/88 $3.00 + .OO Printed in Great Britain Perqamon Press plc
• 1 X -H . R -H 2 X -B r . R -H
• A Practical, Enantioselective Synthetic Route to a Key Precursor to the
• New and Stereospecific Synthesis of Allenes in a Single Step from Propargylic Alcohols
• Tetrahedron Letters,Vo1.30,No.50,pp 6997-7000,1989 0040-4039/89 $3.00 + .OO Printed in Great Britain Perqamon Press plc
• A Practical Synthesis of L-Azatyrosine Andrew G. Myers* and James L. Gleason
• A General Procedure for the Esterification of Carboxylic Acids with Diazoalkanes Generated in Situ by the Oxidation of
• 7922 J. Am. Chem. SOC.1992, I14, 1922-1923 Chart Icrcscopic viscosity can be used to predict the lifetime of
• OUAGUED, GUIZARD, BEZIAT, LARBOT, CRISTAU ET COT 2575 des groupes morpholino varient de 1,627 fi 1,662 A;
• 7574 J. Am. Chem. SOC.1995,117, 7574-7575 Insights into the Mechanism of DNA Cleavage by
• Synthesis and Evaluation of Bishydroquinone Derivatives of (-)-Saframycin A: Identification of a
• Tetrahedron Letters,Vol.Z8,No,39,pp 4493-4496,1987 Printed in Great Britain
• J. Am. Chem. SOC.1995,117, 3057-3083 3057 Synthesis of (&)-7,8-Epoxy-4-basmen-6-oneby a Transannular
• A Solid-Supported, Enantioselective Synthesis Suitable for the Rapid Preparation of Large Numbers of Diverse Structural Analogues of
• On the Mechanism of the Palladium(II)-Catalyzed Decarboxylative Olefination of Arene Carboxylic Acids.
• 7212 J. Am. Chem. SOC. increasing the ligand field strength).I2 In both cases, however,
• Tetrahedron Letters,Vo1.25,No.33,pp 3559-3562,1984 0040-4039/84 $3.00 + .CC Printed in Great Britain 01984 Pergamon Press Ltd.
• Evaluation of antitumor properties of novel saframycin analogs in vitro and in vivo
• On the Inherent Instability of r-Amino r-Fluoro Ketones. Evidence for Their
• J. Am. Chem. Soc. 1990, 112, 9641-9643 9641 Tri-tert-butylated SubPc 1(Scheme I) prepared by a literature
• A Convergent Synthetic Route to (+)-Dynemicin A and Analogs of Wide Structural Variability
• Preparation of the Reagent o-Nitrobenzenesulfonylhydrazide
• Highly Practical Methodology for the Synthesis of D-and L-R-Amino Acids, N-Protected R-Amino Acids, and
• 1948 C21H3oO13 ~ , D. & POPLE, J. A. (1975). J. Am. Chem. Soc. 97,
• 2036 J. Am. Chem. Soc. 1993,115, 2036-2038 1.872-1.831 (m, 2 H), 1.508 (br, 1 H); 'H NMR (61.4 MHz, CHC13)
• A Robust Platform for the Synthesis of New Tetracycline Antibiotics
• Identification of a Novel Michael Acceptor Group for the Reversible Addition of Oxygen-and Sulfur-Based Nucleophiles. Synthesis and Reactivity of the
• Tetrahedron Letters,Vo1_30,No,42,pp 5747-5750,1989 0040-4039/89 $3.00 + .@O Printed in Great Britain Pergamon Press plc
• Lewis acid mediated control of allylic epoxide opening in carbocyclization and halide addition pathways
• J. Am. Chem. SOC.1992,114,9369-9386 9369 170215-E130/91) and GobiernoVasco (Project PGV: 9113.1).
• Tetrahedron Letters,Vol.29,No.44,pp 5609-5612,1988 0040-4039/88 $3.00 + .OO Printed in Great Britain Pergamon Press plc
• Enantioselective Synthesis of Stephacidin B Seth B. Herzon and Andrew G. Myers*
• Use of Lithium Hexafluoroisopropoxide as a Mild Base for
• Synthesis of (-)-Quinocarcin by Directed Condensation of r-Amino Soojin Kwon and Andrew G. Myers*
• One-Step Construction of the Pentacyclic Skeleton of Saframycin A
• Enantioselective Synthesis of (-)-Terpestacin and (-)-Fusaproliferin: Clarification of Optical Rotational Measurements and Absolute
• Highly Efficient Methodology for the Reductive Coupling of Aldehyde Tosylhydrazones with
• COMMUNICATIONS 2732 WILEY-VCH Verlag GmbH, D-69451 Weinheim, 2000 1433-7851/00/3915-2732 $ 17.50+.50/0 Angew. Chem. Int. Ed. 2000, 39, No. 15
• Anti-Selective Epoxidation of Methyl r-Methylene--tert-butyldimethyl-