Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

• ***EMBARGOED UNTIL MARCH 1st Contact: Leslie Schultz
• Airway Epithelial Cells Current Concepts and Challenges
• NATURE MEDICINE VOLUME 6 NUMBER 5 MAY 2000 595 NEW TECHNOLOGY
• rAAV2 Traffics through both the Late and the Recycling Endosomes in a Dose-Dependent Fashion
• 156:201 Fundamentals of Gene Expression Schedule 2010 MWF 11:30 AM
• DownloadedBy:[UniversityofIowaLibraries]At:01:2031July2007 Short Communication
• MOLECULAR AND CELLULAR BIOLOGY, May 2003, p. 30523066 Vol. 23, No. 9 0270-7306/03/$08.00 0 DOI: 10.1128/MCB.23.9.30523066.2003
• 09/13/2007 08:42 PMTweaking Genes Could Extend ALS Survival Page 1 of 1http://health.usnews.com/usnews/health/healthday/070913/tweaking-genes-could-extend-als-survival.htm
• JOURNAL OF VIROLOGY, 0022-538X/00/$04.00 0
• 156.203guideline.doc University of Iowa
• BIOLOGY OF REPRODUCTION 79, 832840 (2008) Published online before print 16 July 2008.
• Factors affecting the efficiency of embryo transfer in the domestic ferret (Mustela putorius furo)
• BIOLOGY OF REPRODUCTION 68, 22972303 (2003) Published online before print 5 February 2003.
• H U M A N G E N E T H E R A P Y 5:1217-1229 (October 1994) Mary Ann Liebert, Inc., Publishers
• Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis
• Species-Specific Differences in Mouse and Human Airway Epithelial Biology of Recombinant
• MOLECULAR AND CELLULAR BIOLOGY, Jan. 2006, p. 140154 Vol. 26, No. 1 0270-7306/06/$08.00 0 doi:10.1128/MCB.26.1.140154.2006
• JOURNAL OF VIROLOGY, Mar. 2002, p. 20432053 Vol. 76, No. 5 0022-538X/02/$04.00 0 DOI: 10.1128/JVI.76.5.20432053.2002
• NHLBI Workshop Summaries Resident Cellular Components of the Human Lung
• NATURE MEDICINE VOLUME 8 NUMBER 3 MARCH 2002 253 Duchenne muscular dystrophy (DMD) is the most common form
• JOURNAL OF VIROLOGY, Apr. 2003, p. 47514759 Vol. 77, No. 8 0022-538X/03/$08.00 0 DOI: 10.1128/JVI.77.8.47514759.2003
• JOURNAL OF VIROLOGY, 0022-538X/99/$04.00 0
• Cloned ferrets produced by somatic cell nuclear transfer Ziyi Li a,b
• Technical advance TheJournalofClinicalInvestigation http://www.jci.org Volume 118 Number 4 April 2008 1571
• Forum Review Article Redox Modifier Genes and Pathways
• Research article TheJournalofClinicalInvestigation http://www.jci.org Volume118 Number2 February2008
• Progress and prospects: techniques for site-directed mutagenesis in animal models
• H U M A N G E N E T H E R A P Y 6:839-851 (July 1995) Mary Ann Liebert, Inc.
• The porcine lung as a potential model for cystic fibrosis Christopher S. Rogers,1
• JOURNAL OF VIROLOGY, 0022-538X/01/$04.00 0 DOI: 10.1128/JVI.75.16.76627671.2001
• HUMAN GENE THERAPY 10:591 602 (March 1, 1999) Mary Ann Liebert, Inc.
• Vol. 333 No. 13 ADENOVIRAL-VECTORMEDIATED GENE TRANSFER FOR CYSTIC FIBROSIS 823 A CONTROLLED STUDY OF ADENOVIRAL-VECTORMEDIATED GENE TRANSFER IN THE
• Efficiency of Chimeraplast Gene Targeting by Direct Nuclear Injection Using a GFP Recovery Assay
• See related Commentary on page viii Characterization of Lef-1 Promoter Segments that Facilitate
• doi:10.1152/ajplung.00140.2010 299:L694-L710, 2010. First published 27 August 2010;Am J Physiol Lung Cell Mol Physiol
• Technical advance TheJournalofClinicalInvestigation http://www.jci.org Volume120 Number9 September2010 3149
• [12] Stem Cells in the Lung By XIAOMING LIU, RYAN R. DRISKELL, and JOHN F. ENGELHARDT
• Experimental Lung Research, 27:121 141, 2001 Copyright 2001 Taylor & Francis
• RAPID COMMUNICATION Structural Analysis of Adeno-Associated Virus Transduction Circular Intermediates
• Aggressive melanoma cells escape from BMP7-mediated autocrine growth inhibition through coordinated
• Introduction The NFB transcription factor family consists of five members
• H U M A N GENE THERAPY 4:771-780 (1993) Mary Ann Liebert, Inc., Publishers
• Adenovirus-mediated gene transfer to human bronchial submucosal glands using xenografts
• H U M A N GENE THERAPY 4:759-769 (1993) Mary Ann Liebert, Inc., Publishers
• Epithelial Sodium Channels Regulate Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channels in
• HUMAN GENE THERAPY 16:11161123 (September 2005) Mary Ann Liebert, Inc.
• The Rockefeller University Press, 0021-9525/98/11/645/13 $2.00 The Journal of Cell Biology, Volume 143, Number 3, November 2, 1998 645657
• Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardiomyocyte hypertrophy
• H U M A N G E N E T H E R A P Y 5:615-639 (1994) Mary Ann Liebert, Inc., Publishers
• University of Iowa College of Medicine
• Subcellular Site of Superoxide Dismutase Expression Differentially Controls AP-1 Activity and Injury in Mouse Liver Following
• Pleiotropic functions of TNF-determine distinct IKK -dependent hepatocellular fates in response to LPS
• 1997;57:5550-5556. Published online December 1, 1997.Cancer Res Ernest W. N. Lam, Ralf Zwacka, John F. Engelhardt, et al.
• Module VI: 2/22/10 -4/2/10 Course 142:217: Epigenetics,cancer and genetic manipulations in mice
• viRoiocy178,419 428(1990) Retrovirus Vector-Targeted Inducible Expression of Human ,&interferon Gene to B-Cells
• BioMed Central Page 1 of 10
• Perspective Am. J. Respir. Cell Mol. Biol. Vol. 24, pp. 649652, 2001
• First-Generation Adenovirus Vectors Shorten Survival Time in a Murine Model of Sepsis1
• Genetic Redox Preconditioning Differentially Modulates AP-1 and NF B Responses Following Cardiac
• Rapid Publication Genotypic Analysis of Respiratory Mucous Sulfation Defects in Cystic Fibrosis
• Proc. Nati. Acad. Sci. USA Vol. 88, pp. 11192-11196, December 1991
• Introduction The cystic fibrosis transmembrane conductance regu-
• JOURNAL OF VIROLOGY, Apr. 2004, p. 41654175 Vol. 78, No. 8 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.8.41654175.2004
• Trans-splicing vectors expand the utility of adeno-associated virus for gene therapy
• Endothelin-1 Stimulates Arterial VCAM-1 Expression Via NADPH OxidaseDerived Superoxide in
• JOURNAL OF VIROLOGY, 0022-538X/99/$04.00 0
• Research article TheJournalofClinicalInvestigation http://www.jci.org
• Targeted Injury of Type II Alveolar Epithelial Cells Induces Pulmonary Fibrosis
• THEJOURNALOF BIOLOGICAL CHEMISTRY 0 1991 by The American Society for Biochemistry and Molecular Biology, Inc
• Am. J. Respir. Cell Mol. Biol. Vol. 24, pp. 195202, 2001 Internet address: www.atsjournals.org
• Original Contribution EFFECTS OF ANTIOXIDANT ENZYME OVEREXPRESSION ON THE
• Selective suppression of cervical cancer Hela cells by 2-O--D-glucopyranosyl-L-ascorbic acid isolated
• BIOLOGY OF REPRODUCTION 66, 13801386 (2002) Conditions for In Vitro Maturation and Artificial Activation of Ferret Oocytes1
• SHORT COMMUNICATION Comparative biology of rAAV transduction in ferret,
• Lysozyme Secretion by Submucosal Glands Protects the Airway from Bacterial Infection
• 287:752-763, 2004. First published Jun 11, 2004; doi:10.1152/ajplung.00026.2004AJP -Lung Duane Abbott, Ningli Cheng, Chris Moothart, Curt D. Sigmund and John F.
• JOURNAL OF VIROLOGY, Mar. 2004, p. 28632874 Vol. 78, No. 6 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.6.28632874.2004
• Expression of c-fos and c-jun During Hepatocellular Remodeling Following Ischemia/Reperfusion in Mouse Liver
• Gene Therapy (1998) 5, 196208 1998 Stockton Press All rights reserved 0969-7128/98 $12.00
• Coupled secretion of chloride and mucus in skin of Xenopus Zaevis: possible role for CFTR
• PII S0360-3016(98)00355-1 BIOLOGY CONTRIBUTIONS
• ELSEVIER Virus Research 48 (1997) 41-56 Structural and functional heterogeneity of integrated
• MOLECULAR AND CELLULAR BIOLOGY, Nov. 2007, p. 75607573 Vol. 27, No. 21 0270-7306/07/$08.00 0 doi:10.1128/MCB.00315-07
• Unique Biologic Properties of Recombinant AAV1 Transduction in Polarized Human Airway Epithelia*
• Lipid Rafts and Caveolin-1 Coordinate Interleukin-1 (IL-1 )-dependentActivationofNF B by Controlling Endocytosis
• original article The American Society of Gene Therapy Molecular Therapy vol. 17 no. 2, 285293 feb. 2009 285
• Forum Review Article Signaling Components of Redox Active Endosomes
• Biochem. J. (2008) 411, 531541 (Printed in Great Britain) doi:10.1042/BJ20071534 531 Endosomal NADPH oxidase regulates c-Src activation following
• original article 2114 www.moleculartherapy.org vol.15no.12,21142123dec.2007
• Interleukin-1 Induction of NF B Is Partially Regulated by H2O2-mediated Activation of NF B-inducing Kinase*
• Iron-mediated H2O2 Production as a Mechanism for Cell Type-specific Inhibition of Tumor Necrosis Factor -Induced but
• JOURNAL OF VIROLOGY, Aug. 2002, p. 76517660 Vol. 76, No. 15 0022-538X/02/$04.00 0 DOI: 10.1128/JVI.76.15.76517660.2002
• Wnt-3A/ -Catenin Signaling Induces Transcription from the LEF-1 Promoter*S
• JOURNAL OF VIROLOGY, 0022-538X/99/$04.00 0
• Am. J. Respir. Cell Mol. Biol. Vol. 18, pp. 750758, 1998 Lef1 Transcription Factor Expression Defines Airway Progenitor
• Manganese Superoxide Dismutase Protects nNOS Neurons from NMDA and Nitric Oxide-Mediated Neurotoxicity
• In vivo analysis of fluid transport in cystic fibrosis airway epithelia of bronchial xenografts
• INTRODUCTION Submucosal glands in the adult human airway are composed
• v-Ha-ras Mitogenic Signaling Through Superoxide and Derived Reactive Oxygen Species
• Pediatric Pathology and Molecular Medicine 20: 349366, 2001 Copyright # 2001 Taylor & Francis
• original article 594 www.moleculartherapy.org vol. 18 no. 3, 594600 mar. 2010
• Cloning and identification of microRNAs in bovine alveolar macrophages
• The Glandular Stem/Progenitor Cell Niche in Airway Development and Repair
• JunD Protects the Liver from Ischemia/Reperfusion Injury by Dampening AP-1 Transcriptional Activation*
• Longitudinal noninvasive monitoring of transcription factor activation in cardiovascular regulatory nuclei using bioluminescence imaging
• ANTIOXIDANTS & REDOX SIGNALING Volume 9, Number 11, 2007
• HUMAN GENE THERAPY 18:8187 (January 2007) Mary Ann Liebert, Inc.
• NATURE BIOTECHNOLOGY VOLUME 24 NUMBER 8 AUGUST 2006 949 AAV hits the genomic bull's-eye
• Intracellular trafficking of adeno-associated viral and JF Engelhardt1,2,3
• MOLECULAR REPRODUCTION AND DEVELOPMENT 72:4047 (2005) Factors Affecting the Electrofusion of Mouse and
• Introduction PITX2 and LEF-1 are two transcription factors whose
• Requirement for Rac1-Dependent NADPH Oxidase in the Cardiovascular and Dipsogenic Actions of Angiotensin II in
• Dual Therapeutic Utility of Proteasome Modulating Agents for Pharmaco-Gene Therapy of the
• Stat3 confers resistance against hypoxia/reoxygenation-induced oxidative injury in hepatocytes through upregulation
• Tyrosine Phosphorylation of I B Activates NF B through a Redox-regulated and c-Src-dependent Mechanism Following
• Signaling Role of Intracellular Iron in NF-B Activation* Received for publication, October 24, 2002, and in revised form, February 25, 2003
• JOURNAL OF VIROLOGY, July 2003, p. 73617366 Vol. 77, No. 13 0022-538X/03/$08.00 0 DOI: 10.1128/JVI.77.13.73617366.2003
• Current Gene Therapy, 2001, 1, 137-147 137 1566-5232/00 $20.00+.00 2001 Bentham Science Publishers Ltd.
• ANTIOXIDANTS & REDOX SIGNALING Volume 3, Number 3, 2001
• Lipopolysaccharide Induces Rac1-dependent Reactive Oxygen Species Formation and Coordinates Tumor Necrosis Factor-
• MOLECULAR THERAPY Vol. 4, No. 4, October 2001 Copyright The American Society of Gene Therapy
• Introduction The domestic ferret (Mustela putorius furos) has become an
• Loss of ATM Function Enhances Recombinant Adeno-Associated Virus Transduction and Integration through Pathways Similar to UV Irradiation
• Airway surface fluid volume and Cl content in cystic fibrosis and normal bronchial xenografts
• Gene Therapy (1999) 6, 14271437 1999 Stockton Press All rights reserved 0969-7128/99 $12.00
• Am. J. Respir. Cell Mol. Biol. Vol. 19, pp. 3037, 1998 Internet address: www.atsjournals.org
• Overexpression of Human Superoxide Dismutase Inhibits Oxidation of Low-Density Lipoprotein by Endothelial Cells
• Nitric oxide inhibits lipopolysaccharide-induced apoptosis in pulmonary artery endothelial cells
• H U M A N G E N E T H E R A P Y 5:501-519 (1994) Mary Ann Liebert, Inc., Publishers
• Proc. Natl. Acad. Sci. USA Vol. 86, pp. 197-201, January 1989
• THEJOURNALOF BIOLOGICALCHEMISTRY Q 1988 by The American Society for Biochemistryand Molecular Biology, Inc
• 09/15/2007 09:59 PMGene inactivation extends life of mice with Lou Gehrig's disease Page 1 of 5http://feeds.bignewsnetwork.com/?sid=282141
• Investor and Media Contact: Stacie D. Byars
• The University of Iowa Carver College of Medicine
• Module V: 1/19/10 -2/19/10 Course 142:215: Transcription and multi-functional regulation by RNA
• Module VI: 2/22/10 -4/2/10 Course 142:216: Chromatin structure and Disease
• HUMAN GENE THERAPY 9:635-648 (March 20, 1998) Mary Ann Liebert, Inc.
• JOURNAL OF VIROLOGY, Jan. 2005, p. 364379 Vol. 79, No. 1 0022-538X/05/$08.00 0 doi:10.1128/JVI.79.1.364379.2005
• Technical advance 1578 TheJournalofClinicalInvestigation http://www.jci.org Volume 118 Number 4 April 2008
• JOURNAL OF VIROLOGY, 0022-538X/00/$04.00 0
• HUMAN GENE THERAPY 10:1553 1557 (June 10, 1999) Mary Ann Liebert, Inc.
• Rapid Publication In Vivo Retroviral Gene Transfer into Human Bronchial Epithelia of Xenografts
• Chromatin Configurations in the Ferret Germinal Vesicle that Reflect Developmental Competence for In Vitro Maturation
• THEJOURNALOF BIOLOGICALCHEMiSTRY 01989by The American Society for Biochemistryand Molecular Biology, Inc.
• JOURNAL OF VIROLOGY, 0022-538X/98/$04.00 0
• Inhibition of Rac1-Derived Reactive Oxygen Species in Nucleus Tractus Solitarius Decreases Blood Pressure and
• INTRODUCTION Submucosal glands (SMGs) secrete fluid, mucous and
• Superoxide Anions and Endothelial Cell Proliferation in Normoglycemia and Hyperglycemia
• Virus Research 104 (2004) 5159 Novel approaches to augment adeno-associated virus
• MOLECULAR AND CELLULAR BIOLOGY, June 2008, p. 37003712 Vol. 28, No. 11 0270-7306/08/$08.00 0 doi:10.1128/MCB.02038-07
• Introduction Cystic fibrosis (CF) is the most common inherited dis-
• Bioelectric Properties of Chloride Channels in Human, Pig, Ferret, and Mouse Airway Epithelia
• Nuclear Transfer of M-phase Ferret Fibroblasts Synchronized with the Microtubule Inhibitor
• 10/12/2005 12:15 PMEngelhardt Receives Extended NIH Funding For Lung Stem Cell Study Page 1 of 2http://www.uiowa.edu/~ournews/2005/october/101205engelhardt.html
• Expression of the Cystic Fibrosis Gene in Adult Human Lung John F. Engelhardt, * Monica Zepeda, * Jonathan A. Cohn, James R. Yankaskas, and James M. Wilson *
• Forum Original Research Communication Endosomal Nox2 Facilitates Redox-Dependent Induction
• ANTIOXIDANTS & REDOX SIGNALING Volume 3, Number 3, 2001
• Page 1 Revised 8/23/2011 ANATOMY & CELL BIOLOGY
• CRITICAL INCIDENT MANAGEMENT PLAN Est. JANUARY 2001
• Fabulous University Programs for Students with Children
• NATIONAL INSTITUTES OF HEALTH | National Cancer Institute LABORATORY OF PATHOLOGY
• OBERMANN GRADUATE INSTITUTE ON ENGAGEMENT AND THE ACADEMY
• workshops Universal Design for Learning Lunch and Learn Series
• Keith Benson/Sam Goody Entertainment Internship
• Research article 3144 TheJournalofClinicalInvestigation http://www.jci.org Volume 121 Number 8 August 2011
• Program Director/Principal Investigator (Last, First, Middle): Campbell, Kevin P. PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page
• Unique Characteristics of AAV1, 2, and 5 Viral Entry, Intracellular Trafficking, and Nuclear Import Define
• Program Director/Principal Investigator (Last, First, Middle): Campbell, Kevin P. PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page
• February 2012 CURRICULUM VITAE
• Alsin and SOD1G93A Proteins Regulate Endosomal Reactive
• Tissue and Cell 43 (2011) 283290 Contents lists available at ScienceDirect
• Copyright Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited. New animal models of cystic fibrosis: what are they teaching us?
• Center for Gene Therapy of Cystic Fibrosis and Other Genetic Instructions for Pilot Grant Applications
• Publications by Gene Therapy Center Members January 2011 -December 2011