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RESEARCH COMMUNICATION siRNAs can function
 

Summary: RESEARCH COMMUNICATION
siRNAs can function
as miRNAs
John G. Doench,1,3
Christian P. Petersen,1,3
and
Phillip A. Sharp1,2,4
1
Center for Cancer Research, Department of Biology, and
2
McGovern Institute for Brain Research, Massachusetts
Institute of Technology,
Cambridge, Massachusetts 02139, USA
With the discovery of RNA interference (RNAi) and re-
lated phenomena, new regulatory roles attributed to
RNA continue to emerge. Here we show, in mammalian
tissue culture, that a short interfering RNA (siRNA) can
repress expression of a target mRNA with partially
complementary binding sites in its 3 UTR, much like
the demonstrated function of endogenously encoded mi-

  

Source: Arnold, Jonathan - Nanoscale Science and Engineering Center & Department of Genetics, University of Georgia

 

Collections: Biotechnology