Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
Effect of Reversible Inactivation of Macaque Lateral Intraparietal Area on Visual and Memory Saccades
 

Summary: Effect of Reversible Inactivation of Macaque Lateral Intraparietal
Area on Visual and Memory Saccades
CHIANG-SHAN RAY LI, PIETRO MAZZONI, AND RICHARD A. ANDERSEN
Division of Biology, California Institute of Technology, Pasadena, California 91125
Li, Chiang-shan Ray, Pietro Mazzoni, and Richard A. Ander-
sen. Effect of reversible inactivation of macaque lateral intraparietal
area on visual and memory saccades. J. Neurophysiol. 81: 18271838,
1999. Previous studies from our laboratory identified a parietal eye
field in the primate lateral intraparietal sulcus, the lateral intraparietal
area (area LIP). Here we further explore the role of area LIP in
processing saccadic eye movements by observing the effects of re-
versible inactivation of this area. One to 2 l of muscimol (8 mg/ml)
were injected at locations where saccade-related activities were re-
corded for each lesion experiment. After the muscimol injection we
observed in two macaque monkeys consistent effects on both the
metrics and dynamics of saccadic eye movements at many injection
sites. These effects usually took place within 1030 min and disap-
peared after 56 h in most cases and certainly when tested the next
day. After muscimol injection memory saccades directed toward the
contralesional and upper space became hypometric, and in one mon-

  

Source: Andersen, Richard - Division of Biology, California Institute of Technology
Columbia University, Department of Neurology, Motor Performance Laboratory

 

Collections: Biology and Medicine