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Copyright 2003 by the Genetics Society of America Linkage Disequilibrium Patterns Across a Recombination Gradient
 

Summary: Copyright 2003 by the Genetics Society of America
Linkage Disequilibrium Patterns Across a Recombination Gradient
in African Drosophila melanogaster
Peter Andolfatto*,,1
and Jeffrey D. Wall,
*Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada,
Institute of Cell, Animal and Population Biology,
University of Edinburgh, Edinburgh EH9 3JT, United Kingdom,
Program in Molecular and Computational Biology,
University of Southern California, Los Angeles, California 90089 and
Department of Human Genetics,
University of Chicago, Chicago, Illinois 60637
Manuscript received March 10, 2003
Accepted for publication July 25, 2003
ABSTRACT
Previous multilocus surveys of nucleotide polymorphism have documented a genome-wide excess of
intralocus linkage disequilibrium (LD) in Drosophila melanogaster and D. simulans relative to expectations
based on estimated mutation and recombination rates and observed levels of diversity. These studies
examined patterns of variation from predominantly non-African populations that are thought to have
recently expanded their ranges from central Africa. Here, we analyze polymorphism data from a Zimbab-

  

Source: Andolfatto, Peter - Department of Ecology and Evolutionary Biology, Princeton University

 

Collections: Biology and Medicine