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Letters to the Editor Am. J. Hum. Genet. 69:11461148, 2001

Summary: 1146
Letters to the Editor
Am. J. Hum. Genet. 69:11461148, 2001
The Importance of Genealogy in Determining
Genetic Associations with Complex Traits
To the Editor:
Most common diseases, such as asthma, type 2 diabetes,
bipolar disorder, and cardiovascular disease, are known
to have genetic components, but the susceptibility genes
have been notoriously difficult to localize and to identify.
These complex diseases likely have a large number of
genetic and nongenetic risk factors that together have
varying effects on phenotype. Many investigators have
recommended founder populations for complex-trait
mapping, with the expectation that fewer susceptibility
alleles will be segregating in these restricted gene pools
(Lander and Schork 1994; Wright et al. 1999; Shifman
and Darvasi 2001). Some or all individuals in these pop-
ulations are inbred, but often the exact relationships
between all members are either unknown or not taken


Source: Abney, Mark - Department of Human Genetics, University of Chicago
Cox, Nancy J. - Section of Genetic Medicine, Department of Medicine, University of Chicago


Collections: Biology and Medicine; Computer Technologies and Information Sciences