Summary: Urothelial pathophysiological changes in
feline interstitial cystitis: a human model
JOHN P. LAVELLE,1 SUSAN A. MEYERS,2 W. GIOVANI RUIZ,2
C. A. TONY BUFFINGTON,3 MARK L. ZEIDEL,2 AND GERARD APODACA2
1Department of Urology, and 2Laboratory of Epithelial Cell Biology, Renal-Electrolyte Division,
Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213;
and 3Ohio State University Veterinary Hospital, Columbus, Ohio 43210-1089
Lavelle, John P., Susan A. Meyers, W. Giovani Ruiz,
C. A. Tony Buffington, Mark L. Zeidel, and Gerard
Apodaca. Urothelial pathophysiological changes in feline
interstitial cystitis: a human model. Am J Physiol Renal
Physiol 278: F540­F553, 2000.--Unique barrier properties of
the urothelial surface membrane permit urine storage. Inter-
stitial cystitis causes disabling dysuria, and frequency. Simi-
larly, feline interstitial cystitis (FIC) occurs in cats. These
studies define the permeability and structural properties of
normal and FIC urothelium. To determine the effects of
bladder filling, groups were studied before and after hydrodis-
tention. Normal urothelium with or without hydrodistention
exhibited high transepithelial resistances (TER) and low

Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh

Collections: Biology and Medicine