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LETTER Communicated by John Rinzel Network Stability from Activity-Dependent Regulation of
 

Summary: LETTER Communicated by John Rinzel
Network Stability from Activity-Dependent Regulation of
Neuronal Conductances
Jorge Golowasch
Michael Casey
L. F. Abbott
Eve Marder
Volen Center and Department of Biology, Brandeis University, Waltham, MA 02454-
9110, U.S.A.
Activity-dependent plasticity appears to play an important role in the
modi cation of neurons and neural circuits that occurs during devel-
opment and learning. Plasticity is also essential for the maintenance of
stable patterns of activity in the face of variable environmental and in-
ternal conditions. Previous theoretical and experimental results suggest
that neurons stabilize their activity by altering the number or character-
istics of ion channels to regulate their intrinsic electrical properties. We
present both experimental and modeling evidence to show that activity-
dependent regulation of conductances, operating at the level of individ-
ual neurons, can also stabilize network activity. These results indicate
that the stomatogastric ganglion of the crab can generate a characteristic

  

Source: Abbott, Laurence - Center for Neurobiology and Behavior & Department of Physiology and Cellular Biophysics, Columbia University

 

Collections: Biology and Medicine