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220 The Journal of Pain, Vol 2, No 4 (August), 2001: pp 220-228 eripheral nerve injuries, resulting from either per-
 

Summary: 220 The Journal of Pain, Vol 2, No 4 (August), 2001: pp 220-228
P
eripheral nerve injuries, resulting from either per-
manent deafferentation or conditions of nerve
inflammation, usually lead to abnormal processing
of innocuous and noxious stimuli, causing sensations
such as phantom perceptions, hyperalgesia, and allody-
nia.1 During the last decade, several animal models for
peripheral neuropathy have been developed that use
chronic nerve constriction injury: (1) partial tight liga-
tion of the sciatic nerve, (2) loose ligation of the sciatic
nerve, and (3) tight ligation of spinal nerves.2-4 In these
models, the behavior of the animals closely mimics the
symptoms observed in patients.
In animals rendered neuropathic by injuring the sci-
atic nerve, single-unit recordings show that somatosen-
sory neurons in the lateral thalamus have activity pat-
terns distinct from those in normal animals: a higher
frequency of spontaneous activity, lower thresholds for
noxious activation, and after discharges outlasting the

  

Source: Apkarian, A. Vania - Department of Physiology, Northwestern University

 

Collections: Biology and Medicine