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Complementation of Physiological and Behavioral Defects by a Slowpoke Ca2
 

Summary: Complementation of Physiological and Behavioral Defects by a
Slowpoke Ca2
-Activated K Channel Transgene
Robert Brenner, Joyce Y. Yu, Karpagam Srinivasan, Lawrence Brewer, James L. Larimer,
Jennette L. Wilbur, and Nigel S. Atkinson
Section of Neurobiology and the Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, U.S.A.
Abstract: The Drosophila slowpoke gene encodes a large
conductance calcium-activated potassium channel used
in neurons, muscle, and some epithelial cells. Tissue-
specific transcriptional promoters and alternative mRNA
splicing generate a large array of transcripts. These dis-
tinct transcripts are thought to tailor the properties of the
channel to the requirements of the cell. Presumably, a
single splice variant cannot satisfy the specific needs of
all cell types. To test this, we examined whether a single
slowpoke splice variant was capable of complementing
all slowpoke behavioral phenotypes. Null mutations in
slowpoke cause animals to be semiflightless and to man-
ifest an inducible "sticky-feet" phenotype. The well-char-
acterized slowpoke transcriptional control region was

  

Source: Atkinson, Nigel - Section of Neurobiology, Division of Biological Sciences, University of Texas at Austin

 

Collections: Biology and Medicine