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Perturbation of Microfluidic Transport Following Electrokinetic Injection through a Nanocapillary Array Membrane: Injection and Biphasic Recovery
 

Summary: Perturbation of Microfluidic Transport Following Electrokinetic Injection through a
Nanocapillary Array Membrane: Injection and Biphasic Recovery
Enid N. Gatimu,
Xiaozhong Jin,
Narayan Aluru,
and Paul W. Bohn*,
Department of Chemical and Biomolecular Engineering, UniVersity of Notre Dame,
Notre Dame, Indiana 46556, and Beckman Institute for AdVanced Science and Technology, UniVersity of
Illinois at Urbana-Champaign, 405 North Mathews AVenue, Urbana, Illinois 618101
ReceiVed: July 15, 2008; ReVised Manuscript ReceiVed: October 9, 2008
Ionic transport in nanopores is dependent on the nature of the electrical communication between the pores
and the surrounding environment. A particularly useful fluidic device structure uses nanopores in nanocapillary
array membranes (NCAMs) as electrically switchable valves between vertically separated microfluidic channels.
In the off-state, the gate isolates the fluidic environments in the microchannels, but when the appropriate
forward-bias voltage is applied, it selectively allows ions and analytes to move between the microchannels.
However, the populations of species in the microfluidic channels are perturbed from their steady-state values
due to ion accumulation and depletion effects. Experiments conducted here characterize the electrical conduction
along the length of a microfluidic channel, and laser-induced fluorescence probes the formation of a high-
and low-concentration regions of fluorescent dye before and after application of forward- and reverse-bias
voltage pulses in both small (a ) 10 nm) and large (a ) 100 nm) pore NCAMs. In all cases, switching from

  

Source: Aluru, Narayana R. - Department of Mechanical and Industrial Engineering, University of Illinois at Urbana-Champaign

 

Collections: Engineering; Materials Science