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410 JID 2005:191 (1 February) Graham et al. M A J O R A R T I C L E
 

Summary: 410 · JID 2005:191 (1 February) · Graham et al.
M A J O R A R T I C L E
Malaria-Filaria Coinfection in Mice Makes Malarial
Disease More Severe unless Filarial Infection
Achieves Patency
Andrea L. Graham, Tracey J. Lamb,a
Andrew F. Read, and Judith E. Allen
Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland
Coinfections are common in natural populations, and the literature suggests that helminth coinfection readily
affects how the immune system manages malaria. For example, type 1­dependent control of malariaparasitemia
might be impaired by the type 2 milieu of preexisting helminth infection. Alternatively, immunomodulatory
effects of helminths might affect the likelihood of malarial immunopathology. Using rodent models oflymphatic
filariasis (Litomosoides sigmodontis) and noncerebral malaria (clone AS Plasmodium chabaudi chabaudi), we
quantified disease severity, parasitemia, and polyclonal splenic immune responses in BALB/c mice. We found
that coinfected mice, particularly those that did not have microfilaremia (Mf ), had more severe anemia and
loss of body mass than did mice with malaria alone. Even when controlling for parasitemia, malaria was most
severe in Mf coinfected mice, and this was associated with increased interferon-g responsiveness. Thus, in
Mf mice, filariasis upset a delicate immunological balance in malaria infection and exacerbated malaria-
induced immunopathology.
Helminth infections are prevalent throughout tropical

  

Source: Allen, Judith - School of Biological Sciences, University of Edinburgh
Graham, Andrea L. - School of Biological Sciences, University of Edinburgh
Read, Andrew - Center for Infectious Disease Dynamics & Department of Entomology, Pennsylvania State University

 

Collections: Biology and Medicine; Environmental Sciences and Ecology