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Copyright 2004 by the Genetics Society of America DOI: 10.1534/genetics.103.023291

Summary: Copyright 2004 by the Genetics Society of America
DOI: 10.1534/genetics.103.023291
Quantitative Trait Loci Affecting Life Span in Replicated Populations
of Drosophila melanogaster. II. Response to Selection
Robert K. Valenzuela, Scott N. Forbes,1
Paul Keim and Philip M. Service2
Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona 86011
Manuscript received October 15, 2003
Accepted for publication June 9, 2004
Three selection experiments were used to identify chromosome regions that contain QTL affecting
late-life and early-life fitness in Drosophila melanogaster. The selection experiments were initiated by crossing
pairs of inbred lines that had been derived from outbred laboratory populations that had different mean
life spans. QTL regions were located by association with microsatellite markers that showed significant
selection responses. Regions between recombination map positions 54 and 81 on chromosome 2, between
0 and 30 on chromosome 3, and near locations 49 and 81 on chromosome 3 had the strongest support
as locations of life-span QTL. There was good general agreement between the life-span QTL regions that
were identified by selection and those that were identified in a companion recombination mapping
experiment that used the same fly stocks. Many marker loci responded in opposite directions to selection
for late- and early-life fitness, indicating negative genetic correlations or trade-offs between those traits.


Source: Allan, Gery - Department of Biological Sciences, Northern Arizona University


Collections: Biology and Medicine; Environmental Sciences and Ecology