Summary: Molecular Dynamic Simulations onMolecular Dynamic Simulations on
RH50 from Nitrosomonas europaea
Ugur Akgun and Shahram Khademi
U i it f I R J d L ill A C C ll f M di iUniversity of Iowa, Roy J. and Lucille A. Carver College of Medicine
Department of Biochemistry, Iowa City, IA 52242
The Rhesus (Rh) proteins are a member ofAmt/MEP/Rh superfamily of membrane
proteins, found throughout the animal kingdom that also exists in a number of lower
Since Rh proteins are related to the AmtB protein, there is considerable expectation that
they function as ammonia channels. However Rh protein has also been considered ay p
channel for CO2 .
Here we discuss the highlights of the structural differences and similarities between theHere, we discuss the highlights of the structural differences and similarities between the
only two known structures from Rh/MEP/Amt superfamily;AmtB from E.Coli  and
Rh50 from Nitrosomonas europae.
Here, we determine the substrate selectivity, mechanism of conduction, and energy
profiles of substrate conduction for Rh50 using Molecular Dynamic (MD) simulations.
The Rhesus (Rh) blood group system is the most polymorphic of the
human blood groups and, next to theABO system, is the most