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Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology

Summary: Hindawi Publishing Corporation
Journal of Biomedicine and Biotechnology
Volume 2010, Article ID 262609, 14 pages
Review Article
Similarity and Diversity in Macrophage Activation by
Nematodes, Trematodes, and Cestodes
Stephen J. Jenkins and Judith E. Allen
Institute of Immunology & Infection Research, University of Edinburgh, Edinburgh EH9 3JT, UK
Correspondence should be addressed to Judith E. Allen, j.allen@ed.ac.uk
Received 15 September 2009; Accepted 7 October 2009
Academic Editor: Luis I. Terrazas
Copyright 2010 S. J. Jenkins and J. E. Allen. This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
This review summarizes current knowledge of macrophages in helminth infections, with a focus not only on delineating the
striking similarities in macrophage phenotype between diverse infections but also on highlighting the differences. Findings from
many different labs illustrate that macrophages in helminth infection can act as anti-parasite effectors but can also act as powerful
immune suppressors. The specific role for their alternative (Th2-mediated) activation in helminth killing or expulsion versus
immune regulation remains to be determined. Meanwhile, the rapid growth in knowledge of alternatively activated macrophages


Source: Allen, Judith - School of Biological Sciences, University of Edinburgh


Collections: Biology and Medicine