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Protein Dynamics in Drug Combinations: a Linear Superposition
 

Summary: Protein Dynamics in Drug Combinations:
a Linear Superposition
of Individual-Drug Responses
Naama Geva-Zatorsky,1,2 Erez Dekel,1,2 Ariel A. Cohen,1 Tamar Danon,1 Lydia Cohen,1 and Uri Alon1,*
1Departments of Molecular Cell Biology and Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100, Israel
2These authors contributed equally to this work
*Correspondence: urialon@weizmann.ac.il
DOI 10.1016/j.cell.2010.02.011
SUMMARY
Drugs and drug combinations have complex biolog-
ical effects on cells and organisms. Little is known
about how drugs affect protein dynamics that deter-
mine these effects. Here, we use a dynamic proteo-
mics approach to accurately follow 15 protein levels
in human cells in response to 13 different drugs. We
find that protein dynamics in response to combina-
tions of drugs are described accurately by a linear
superposition (weighted sum) of their response to
individual drugs. The weights in this superposition
describe the relative impact of each drug on each

  

Source: Alon, Uri - Departments of Molecular Cell Biology & Physics of Complex Systems, Weizmann Institute of Science

 

Collections: Biology and Medicine