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AluGene: a database of Alu elements incorporated within protein-coding genes
 

Summary: AluGene: a database of Alu elements incorporated
within protein-coding genes
Tal Dagan*, Rotem Sorek1,2
, Eilon Sharon, Gil Ast1
and Dan Graur
Department of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Israel,
1
Department of Human Genetics and Molecular Medicine, Sackler Faculty of Medicine, Tel Aviv University,
Ramat Aviv 69978, Israel and 2
Compugen, 72 Pinchas Rosen Street, Tel Aviv 69512, Israel
Received August 20, 2003; Revised and Accepted October 27, 2003
ABSTRACT
Alu elements are short interspersed elements
(SINEs) ~300 nucleotides in length. More than
1 million Alus are found in the human genome.
Despite their being genetically functionless, recent
Ūndings suggest that Alu elements may have a
broad evolutionary impact by affecting gene struc-
tures, protein sequences, splicing motifs and
expression patterns. Because of these effects, com-

  

Source: Ast, Gil - Department of Molecular Genetics and Biochemistry, Tel Aviv University
Graur, Dan - Department of Biology and Biochemistry, University of Houston
Sorek, Rotem - Department of Molecular Genetics, Weizmann Institute of Science

 

Collections: Biology and Medicine; Environmental Sciences and Ecology