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Communication Vol. 268, So. 29, Issue of October 15. pp. 21505-21508, 1993 THEJOI.HX,AIOF BIUI.W;IC~I.CHE\IISI.IO
 

Summary: Communication Vol. 268, So. 29, Issue of October 15. pp. 21505-21508, 1993
THEJOI.HX,AIOF BIUI.W;IC~I.CHE\IISI.IO
0 1993 by The American Society for Biochemistry and Molecular Biology, Inc.
Printed in U.S.A.
Amino Acids Lining the Channel
of the ylhinobutyric Acid
Type A Receptor Identifiedby
Cysteine Substitution*
(Received for publication, July 21, 1993, and in revised form,
August 5, 1993)
Ming Xu$# and MylesH. Akabas$PllI1
From the $Centerfor Molecular Recognition and the
$Department of Physiology and Cellular Biophysics and
the IDepartment of Medicine, College of Physicians
and Surgeons, Columbia University,
New York, NewYork 10032
The binding of y-aminobutyric acid(GABA)to y-ami-
nobutyric acid type A (GABA,) receptors triggers the
openingof an anion-selectivechannel.To identify amino
acid residues that line the channel, we combined cys-

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

 

Collections: Biology and Medicine