Summary: This agent, M100,907 has been characterized as
a 5HT2A receptor antagonist. We have found it
to work in low dosage in an animal model of
psychosis that can be induced by lowering glu-
tamatergic function (37­39). Recently this com-
pound has also been found to possess antipsy-
chotic properties in schizophrenic patients (40).
These and other observations support the view
that in addition to dopamine, glutamate and se-
rotonin are also critically involved in schizophre-
nia. It is likely that other neurotransmitters, such
as noradrenaline, acetylcholine, and -aminobu-
tyric acid (GABA), will soon be added to this
list.
References
1. A. Carlsson, P. A. Shore, B. B. Brodie, J. Pharmacol.
Exp. Ther. 120, 334 (1957).
2. A. Carlsson, N.-Å. Hillarp, Kungl. Fysiogr. Sa¨llsk. Lund
fo¨rhandl. 26, 1 (1956).
3. Å. Bertler, A. Carlsson, E. Rosengren, Naturvissen-

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

Collections: Biology and Medicine