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Published: February 25, 2011 r 2011 American Chemical Society 2261 dx.doi.org/10.1021/jo102305q |J. Org. Chem. 2011, 76, 22612264
 

Summary: Published: February 25, 2011
r 2011 American Chemical Society 2261 dx.doi.org/10.1021/jo102305q |J. Org. Chem. 2011, 76, 22612264
NOTE
pubs.acs.org/joc
A Rapid, One-Pot, Microwave-Influenced Synthesis of Spiro-2,5-
diketopiperazines via a Cascade Ugi/6-Exo-Trig Aza-Michael Reaction
Soumava Santra and Peter R. Andreana*
Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, United States
bS Supporting Information
ABSTRACT: A rapid, cascade reaction process has been developed
to access biologically validated spiro-2,5-diketopiperazines. The facile
and environmentally benign method capitalizes on commercially
available starting reagents for a sequential Ugi/6-exo-trig aza-Michael
reaction, water as a solvent, and microwave irradiation without any
extraneous additives.
The vast majority of prescription drugs are small molecule
natural products, derivatives thereof, or synthetically de-
signed constructs aimed at a biological target possessing some
specific function.1
The involvement of heteroatoms for hetero-

  

Source: Andreana, Peter R. - Department of Chemistry, Wayne State University

 

Collections: Chemistry