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Summary: Enhanced fMRI Response Detection and Reduced
Latency through Spatial Analysis of BOLD Signals
Bernard Ng1
, Rafeef Abugharbieh1
, Martin J. McKeown2
1
Biomedical Image and Signal Computing Laboratory, Dept. of Elect. & Comp. Eng.,
2
Department of Medicine (Neurology), Pacific Parkinson's Research Center,
The University of British Columbia, Vancouver, BC, Canada
bernardn@ece.ubc.ca, rafeef@ece.ubc.ca, mmckeown@interchange.ubc.ca
Abstract. In conventional functional magnetic resonance imaging (fMRI)
analysis, activation is often inferred by examining only the intensity modulation
of blood-oxygen-level dependent (BOLD) signal of each voxel in isolation or in
small, local clusters. However, as has been recently demonstrated, activation
can in fact be detected by examining the spatial modulation of the BOLD
distribution within a region of interest (ROI). In this paper, we propose and
demonstrate with real fMRI data that analyzing such spatial changes can
enhance the effect size of fMRI response detection over using intensity
information alone. Furthermore, we show that such spatial changes consistently
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