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Activity-Dependent Regulation of Potassium Currents in an Identified Neuron of the Stomatogastric Ganglion of the Crab
 

Summary: Activity-Dependent Regulation of Potassium Currents in an
Identified Neuron of the Stomatogastric Ganglion of the Crab
Cancer borealis
Jorge Golowasch, L. F. Abbott, and Eve Marder
Volen Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454
Identified neurons of the stomatogastric ganglion of the crab
Cancer borealis were voltage-clamped, and the current densi-
ties of three K currents were measured. The current densities
of each of the three K currents varied twofold to fivefold in
inferior cardiac (IC) neurons from different animals. Convention-
ally, this degree of variability has been attributed to experimen-
tal artifacts. Instead, we suggest that it reflects a natural vari-
ability that may be related to an underlying process of plasticity.
First, we found that there is no fixed ratio among the three K
currents. Second, we found that several hours of stimulation
with depolarizing current pulses (0.5 sec duration at 1 Hz)
altered the current density of the Ca2
-dependent outward
current, IK(Ca) , and the transient outward current, IA. This stim-
ulation paradigm mimics the normal pattern of activity for these

  

Source: Abbott, Laurence - Center for Neurobiology and Behavior & Department of Physiology and Cellular Biophysics, Columbia University

 

Collections: Biology and Medicine