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Summary: COMMENTARY
388 volume 16 | number 4 | April 2010 NATuRE MEdiCiNE
Getting biological about the genetics of
diabetes
Christopher B Newgard & Alan D Attie
New technology has provided methods
for collecting large amounts of data
reflecting gene expression, metabolite
and protein abundance, and post-
translational modification of proteins.
Integration of these various data sets
enable the genetic mapping of many new
phenotypes and facilitates the creation
of network models that link genetic
variation with intermediate traits leading
to human disease. The first round of
genome-wide association studies has not
accounted for common human diseases
to the extent that was expected. New
phenotyping approaches and methods
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