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Summary: Sparse Instrumental Variables (SPIV) for
Genome-Wide Studies
Felix V. Agakov
PHS, Medical School
University of Edinburgh
felixa@aivalley.com
Paul McKeigue
PHS, Medical School
University of Edinburgh
paul.mckeigue@ed.ac.uk
Jon Krohn
WTCHG, Oxford
jon.krohn@magd.ox.ac.uk
Amos Storkey
School of Informatics
University of Edinburgh
a.storkey@ed.ac.uk
Abstract
This paper describes a probabilistic framework for studying associations between
multiple genotypes, biomarkers, and phenotypic traits in the presence of noise and
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