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The Role of the Granuloma in Expansion and Dissemination

Summary: The Role of the Granuloma in
Expansion and Dissemination
of Early Tuberculous Infection
J. Muse Davis1 and Lalita Ramakrishnan2,*
1Immunology and Molecular Pathogenesis Graduate Program, Emory University, Atlanta, GA 30322, USA
2Departments of Microbiology, Medicine, and Immunology, University of Washington, Seattle, WA 98195, USA
*Correspondence: lalitar@u.washington.edu
DOI 10.1016/j.cell.2008.11.014
Granulomas, organized aggregates of immune cells,
form in response to persistent stimuli and are hall-
marks of tuberculosis. Tuberculous granulomas
have long been considered host-protective struc-
tures formed to contain infection. However, work in
zebrafish infected with Mycobacterium marinum
suggests that granulomas contribute to early bacte-
rial growth. Here we use quantitative intravital micros-
copy to reveal distinct steps of granuloma formation
and assess their consequence for infection. Intracel-
lularmycobacteriausetheESX-1/RD1virulence locus


Source: Arnold, Jonathan - Nanoscale Science and Engineering Center & Department of Genetics, University of Georgia


Collections: Biotechnology