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BioMed Central Page 1 of 14

Summary: BioMed Central
Page 1 of 14
(page number not for citation purposes)
BMC Biology
Open AccessResearch article
Minor shift in background substitutional patterns in the Drosophila
saltans and willistoni lineages is insufficient to explain GC content of
coding sequences
Nadia D Singh*1, Peter F Arndt2 and Dmitri A Petrov1
Address: 1Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA and 2Max Planck for Molecular
Genetics, 14195 Berlin, Germany
Email: Nadia D Singh* - ndsingh@stanford.edu; Peter F Arndt - arndt@molgen.mpg.de; Dmitri A Petrov - dpetrov@stanford.edu
* Corresponding author
Background: Several lines of evidence suggest that codon usage in the Drosophila saltans and D.
willistoni lineages has shifted towards a less frequent use of GC-ending codons. Introns in these
lineages show a parallel shift toward a lower GC content. These patterns have been alternatively
ascribed to either a shift in mutational patterns or changes in the definition of preferred and
unpreferred codons in these lineages.
Results and discussion: To gain additional insight into this question, we quantified background


Source: Arndt, Peter - Max-Planck-Institut für molekulare Genetik
Spang, Rainer - Computational Molecular Biology Group, Max-Planck-Institut für molekulare Genetik


Collections: Biology and Medicine; Biotechnology; Computer Technologies and Information Sciences; Physics